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Search of human proteins with 194353970
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
(465 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] 951 0.0
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens] 442 e-124
gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens] 422 e-118
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 229 3e-60
gi|4503385 dopamine receptor D2 isoform long [Homo sapiens] 229 4e-60
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 210 2e-54
gi|32483397 dopamine receptor D4 [Homo sapiens] 208 7e-54
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 194 1e-49
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 193 2e-49
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 183 3e-46
gi|194018562 histamine receptor H3 [Homo sapiens] 176 3e-44
gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens] 169 5e-42
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 164 1e-40
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 162 6e-40
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 161 1e-39
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 158 9e-39
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 158 9e-39
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 158 9e-39
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 158 9e-39
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 154 2e-37
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 150 2e-36
gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens] 149 7e-36
gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens] 149 7e-36
gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens] 149 7e-36
gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens] 149 7e-36
gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens] 149 7e-36
gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens] 149 7e-36
gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens] 149 7e-36
gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens] 149 7e-36
gi|149158709 histamine receptor H1 [Homo sapiens] 148 1e-35
>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
Length = 465
Score = 951 bits (2459), Expect = 0.0
Identities = 465/465 (100%), Positives = 465/465 (100%)
Query: 1 MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLML 60
MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLML
Sbjct: 1 MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLML 60
Query: 61 LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAW 120
LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAW
Sbjct: 61 LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAW 120
Query: 121 CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVIS 180
CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVIS
Sbjct: 121 CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVIS 180
Query: 181 FPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKR 240
FPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKR
Sbjct: 181 FPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKR 240
Query: 241 RTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGP 300
RTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGP
Sbjct: 241 RTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGP 300
Query: 301 RDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTP 360
RDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTP
Sbjct: 301 RDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTP 360
Query: 361 AAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPR 420
AAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPR
Sbjct: 361 AAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPR 420
Query: 421 TLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV 465
TLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
Sbjct: 421 TLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV 465
>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
Length = 462
Score = 442 bits (1138), Expect = e-124
Identities = 255/470 (54%), Positives = 297/470 (63%), Gaps = 62/470 (13%)
Query: 25 NASWNGTEAPGGGARAT---------PYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFT 75
NAS G GG A A+ YS L + G L++ TV GNVLV+IAV T
Sbjct: 19 NASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLT 78
Query: 76 SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS 135
SRAL+APQNLFLVSLASADILVATLV+PFSLANE+M YWYFG+ WC +YLALDVLFCTSS
Sbjct: 79 SRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSS 138
Query: 136 IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGG 195
IVHLCAISLDRYWS+TQA+EYNLKRTPRR+KA I+ VW+ISAVISFPPL+S+ ++ G
Sbjct: 139 IVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGA- 197
Query: 196 PQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVA 255
A P+C +ND+ WY++SSCIGSFFAPCLIM LVY RIY++AK RTR +R P
Sbjct: 198 ---AYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAP---V 251
Query: 256 APPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSD 315
P G + NGLG AG G A P PA P +ESS++
Sbjct: 252 GPDGASPTTENGLGAAAGAGENGHCAPP-----------PADVEP--------DESSAAA 292
Query: 316 HAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAA----GPGEERVGA 371
R G R RG G+ +A A G GPGA G A GPG A
Sbjct: 293 ERRRRRGALR--RG--GRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRA 348
Query: 372 AKAS-------RWRGR---------QNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV- 414
+ S R R R Q REKRFTFVLAVV+GVFV+CWFPFFF+Y+L +
Sbjct: 349 SSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGIC 408
Query: 415 --GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRK 462
C VP LFKFFFW GYCNSSLNPVIYT+FN DFRR+FK IL R R+
Sbjct: 409 REACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRR 458
>gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]
Length = 450
Score = 422 bits (1084), Expect = e-118
Identities = 242/453 (53%), Positives = 290/453 (64%), Gaps = 51/453 (11%)
Query: 42 PYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLV 101
PYS+Q T + L+L T+FGN LVI+AV TSR+L+APQNLFLVSLA+ADILVATL+
Sbjct: 6 PYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLI 65
Query: 102 IPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRT 161
IPFSLANE++GYWYF + WCE+YLALDVLFCTSSIVHLCAISLDRYW++++A+EYN KRT
Sbjct: 66 IPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRT 125
Query: 162 PRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQP-AEPRCEINDQKWYVISSCIGSF 220
PRRIK II+TVW+I+AVIS PPLI G GPQP P+C++N + WY+++S IGSF
Sbjct: 126 PRRIKCIILTVWLIAAVISLPPLI----YKGDQGPQPRGRPQCKLNQEAWYILASSIGSF 181
Query: 221 FAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAE 280
FAPCLIMILVY+RIY IAKR +RRGP A P G ++P P+ A+
Sbjct: 182 FAPCLIMILVYLRIYLIAKR-----SNRRGPRAKGGPGQGESKQPR---PDHGGALASAK 233
Query: 281 AEPLPT-----QLNG---APGEPAPA-GPRDTDALDLEES------------------SS 313
L + ++NG + GE P DT L S S
Sbjct: 234 LPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASP 293
Query: 314 SDHAERPPGPRRPER--GPRGKGKARASQVKPGDSLPRRGPG-ATGIGTPAAGPGEERVG 370
D AE E P+ + AS P P+ AT G G G VG
Sbjct: 294 EDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRG---VG 350
Query: 371 AAKASRWRGRQ--NREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV---GCSVPRTLFKF 425
A WR R REKRFTFVLAVVIGVFV+CWFPFFF+Y+L A+ C VP LF+F
Sbjct: 351 AIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQF 410
Query: 426 FFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCR 458
FFW GYCNSSLNPVIYTIFN DFRRAF++ILCR
Sbjct: 411 FFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCR 443
>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
Length = 414
Score = 229 bits (585), Expect = 3e-60
Identities = 142/412 (34%), Positives = 218/412 (52%), Gaps = 48/412 (11%)
Query: 54 LAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY 113
L LL+ + VFGNVLV +AV +AL+ N +VSLA AD+LVATLV+P+ + EV+G
Sbjct: 40 LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99
Query: 114 WYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLK-RTPRRIKAIIITV 172
W F + C+I++ LDV+ CT+SI++LCAIS+DRY ++ + YN + + RR+ +I V
Sbjct: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159
Query: 173 WVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYV 232
WV+S IS P L + + C I + + V SS + SF+ P ++ +LVY+
Sbjct: 160 WVLSFTISCPLLFGLNNAD--------QNECIIANPAFVVYSSIV-SFYVPFIVTLLVYI 210
Query: 233 RIYQIAKRRTRVPPSRRGPDA----VAAPPGGTERRPNGLGPE---RSAGPGGAEAEPLP 285
+IY + +RR + ++R A + AP RR L E ++ P P+P
Sbjct: 211 KIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIP 270
Query: 286 TQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGD 345
+ L L + S P P +PE+ K + +++
Sbjct: 271 PSHH---------------QLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQ 315
Query: 346 SLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPF 405
++P G+ R SR + Q +EK+ T +LA+V+GVF++CW PF
Sbjct: 316 TMPN---------------GKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPF 360
Query: 406 FFTYTLTA-VGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456
F T+ L C++P L+ F W GY NS++NP+IYT FN +FR+AF KIL
Sbjct: 361 FITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 412
>gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]
Length = 443
Score = 229 bits (584), Expect = 4e-60
Identities = 145/426 (34%), Positives = 221/426 (51%), Gaps = 47/426 (11%)
Query: 54 LAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY 113
L LL+ + VFGNVLV +AV +AL+ N +VSLA AD+LVATLV+P+ + EV+G
Sbjct: 40 LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99
Query: 114 WYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLK-RTPRRIKAIIITV 172
W F + C+I++ LDV+ CT+SI++LCAIS+DRY ++ + YN + + RR+ +I V
Sbjct: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159
Query: 173 WVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYV 232
WV+S IS P L + + C I + + V SS + SF+ P ++ +LVY+
Sbjct: 160 WVLSFTISCPLLFGLNNAD--------QNECIIANPAFVVYSSIV-SFYVPFIVTLLVYI 210
Query: 233 RIYQIAKRRTRVPPSRRGPDA----VAAPPGGTERRP------------NGLGP-ERSAG 275
+IY + +RR + ++R A + AP G P NG P R
Sbjct: 211 KIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRV 270
Query: 276 PGGAEAEPLPTQLNGAPGEPAPAG----PRDTDALDLEESSSSDHAERPPGPRRPERGPR 331
A+ L ++ + P P L L + S P P +PE+
Sbjct: 271 EAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGH 330
Query: 332 GKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVL 391
K + +++ ++P G+ R SR + Q +EK+ T +L
Sbjct: 331 AKDHPKIAKIFEIQTMPN---------------GKTRTSLKTMSRRKLSQQKEKKATQML 375
Query: 392 AVVIGVFVVCWFPFFFTYTLTA-VGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRR 450
A+V+GVF++CW PFF T+ L C++P L+ F W GY NS++NP+IYT FN +FR+
Sbjct: 376 AIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRK 435
Query: 451 AFKKIL 456
AF KIL
Sbjct: 436 AFLKIL 441
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 210 bits (535), Expect = 2e-54
Identities = 154/462 (33%), Positives = 214/462 (46%), Gaps = 68/462 (14%)
Query: 16 MGSLQPDAGNASWNGTEAP-----GG---GARATPYSLQVTLTLVCLAGLLMLLTVFGNV 67
M L P GN N T P GG G S QV +L L G L+ V GN
Sbjct: 1 MDVLSPGQGN---NTTSPPAPFETGGNTTGISDVTVSYQVITSL--LLGTLIFCAVLGNA 55
Query: 68 LVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLAL 127
V+ A+ R+L+ N + SLA D++V+ LV+P + +V+ W G+ C++++AL
Sbjct: 56 CVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIAL 115
Query: 128 DVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISI 187
DVL CTSSI+HLCAI+LDRYW+IT I+Y KRTPRR A+I W+I +IS PP++
Sbjct: 116 DVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGW 175
Query: 188 EKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAK---RRTRV 244
P C I+ Y I S G+F+ P L+M+++Y RI++ A+ R+T
Sbjct: 176 RTPEDRSDPD----ACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVK 231
Query: 245 PPSRRGPDA--VAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRD 302
+ G D A+P ++ NG R+ G NGA + D
Sbjct: 232 KVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQ-----GDD 286
Query: 303 TDALDLEE----SSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIG 358
AL++ E +S +H P E GP
Sbjct: 287 GAALEVIEVHRVGNSKEHLPLP-----SEAGP---------------------------- 313
Query: 359 TPAAGPGEERVGAAKASRWRGRQ-NREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV--- 414
TP A ER A R RE++ L +++G F++CW PFF +
Sbjct: 314 TPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCES 373
Query: 415 GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456
C +P L W GY NS LNPVIY FN DF+ AFKKI+
Sbjct: 374 SCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII 415
>gi|32483397 dopamine receptor D4 [Homo sapiens]
Length = 419
Score = 208 bits (530), Expect = 7e-54
Identities = 164/472 (34%), Positives = 227/472 (48%), Gaps = 89/472 (18%)
Query: 9 AEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVF-GNV 67
A+G A G P AG ++ G GA A + G+L++ V GN
Sbjct: 9 ADGLLAGRG---PAAGASAGASAGLAGQGAAAL------------VGGVLLIGAVLAGNS 53
Query: 68 LVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG-YWYFGKAWCEIYLA 126
LV ++V T RAL+ P N F+VSLA+AD+L+A LV+P + +EV G W C+ +A
Sbjct: 54 LVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMA 113
Query: 127 LDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLIS 186
+DV+ CT+SI +LCAIS+DR+ ++ + YN + RR +I W++SA ++ P L
Sbjct: 114 MDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCG 173
Query: 187 IEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVY------VRIYQIAKR 240
+ G PA R E D YV+ S + SFF PC +M+L+Y ++ +++A+R
Sbjct: 174 LNDV---RGRDPAVCRLEDRD---YVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARR 227
Query: 241 RTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGP 300
A G RRP+G GP P PT PAP P
Sbjct: 228 --------------AKLHGRAPRRPSGPGP------------PSPT-------PPAPRLP 254
Query: 301 RDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSL-PRRGPGATGI-- 357
+D D PP P P RGP G A A+ P D P P A G+
Sbjct: 255 QDPCGPDC----------APPAPGLP-RGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPP 303
Query: 358 ---GTPAAGPGEERVGA-----AKASRWRGR---QNREKRFTFVLAVVIGVFVVCWFPFF 406
G+ A P R A +R R R RE++ VL VV+G F++CW PFF
Sbjct: 304 DPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFF 363
Query: 407 FTYTLTAV--GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456
+ A+ CSVP L W GY NS+LNPVIYT+FN +FR F+K L
Sbjct: 364 VVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKAL 415
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 194 bits (493), Expect = 1e-49
Identities = 153/456 (33%), Positives = 219/456 (48%), Gaps = 73/456 (16%)
Query: 16 MGSLQPDAGNASWN-GTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVF 74
M SL +G+ ++ G E G ++A P++ L+L VFGN LV +AV
Sbjct: 1 MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCA-----LILAIVFGNGLVCMAVL 55
Query: 75 TSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG-YWYFGKAWCEIYLALDVLFCT 133
RAL+ N +VSLA AD+LVATLV+P+ + EV G W F + C++++ LDV+ CT
Sbjct: 56 KERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT 115
Query: 134 SSIVHLCAISLDRYWSITQAIEYNL---KRTPRRIKAIIITVWVISAVISFPPLISIEKK 190
+SI++LCAIS+DRY ++ + Y + + RR+ +I VWV++ +S P L
Sbjct: 116 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT 175
Query: 191 GGGGGPQPAEPR-CEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRR 249
G +P C I++ +VI S + SF+ P + +LVY RIY + K+R
Sbjct: 176 G--------DPTVCSISNPD-FVIYSSVVSFYLPFGVTVLVYARIYVVLKQR-------- 218
Query: 250 GPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGA-PGEPAPAGPRDTDALDL 308
RR L + S Q N PG P D L+L
Sbjct: 219 -------------RRKRILTRQNS-------------QCNSVRPGFPQQTLSPDPAHLEL 252
Query: 309 EESSSSDHAERPPGPRRPERGPRGKGKAR-----ASQVKPGDSLPRRGPGATGIGTP-AA 362
+ S GP ERG K + + + + P SL R + T
Sbjct: 253 KRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKL 312
Query: 363 GPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLT--AVGCSVPR 420
GP + RG REK+ T ++A+V+G F+VCW PFF T+ L C V
Sbjct: 313 GPLQP----------RGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSP 362
Query: 421 TLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456
L+ W GY NS+LNPVIYT FN +FR+AF KIL
Sbjct: 363 ELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 398
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 193 bits (491), Expect = 2e-49
Identities = 150/464 (32%), Positives = 214/464 (46%), Gaps = 90/464 (19%)
Query: 7 PLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGN 66
PL +G+ L P + AS P P S Q T + L L++LL V GN
Sbjct: 21 PLPDGAATAARLLVPASPPASL----LPPASESPEPLSQQWTAGMGLLMALIVLLIVAGN 76
Query: 67 VLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLA 126
VLVI+A+ + L+ NLF++SLASAD+++ LV+PF V G W +G +CE++ +
Sbjct: 77 VLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTS 136
Query: 127 LDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLIS 186
+DVL T+SI LC I+LDRY +IT Y T R + ++ TVW ISA++SF P++
Sbjct: 137 VDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILM 196
Query: 187 IEKKGGGGGPQPA--EPR-CEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTR 243
+ + +P+ C+ + Y I+S + SF+ P IM VY+R+++ A+++ +
Sbjct: 197 HWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVK 256
Query: 244 VPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDT 303
S ERR G GP R P P P PAPA
Sbjct: 257 KIDS-------------CERRFLG-GPARPPSP-----SPSPV--------PAPA----- 284
Query: 304 DALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAG 363
PPGP R P A P A
Sbjct: 285 ---------------PPPGPPR--------------------------PAAAAATAPLA- 302
Query: 364 PGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCS-VPRTL 422
R G + SR RE++ L +++GVF +CW PFF + A VP L
Sbjct: 303 --NGRAGKRRPSRLVAL--REQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRL 358
Query: 423 FKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILC---RGDRKR 463
F FF W GY NS+ NP+IY + DFR+AF+ +LC R R+R
Sbjct: 359 FVFFNWLGYANSAFNPIIY-CRSPDFRKAFQGLLCCARRAARRR 401
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 183 bits (465), Expect = 3e-46
Identities = 144/450 (32%), Positives = 207/450 (46%), Gaps = 94/450 (20%)
Query: 16 MGSLQPDAGNASWN-GTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVF 74
M SL +G+ ++ G E G ++A P++ L+L VFGN LV +AV
Sbjct: 1 MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCA-----LILAIVFGNGLVCMAVL 55
Query: 75 TSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMG-YWYFGKAWCEIYLALDVLFCT 133
RAL+ N +VSLA AD+LVATLV+P+ + EV G W F + C++++ LDV+ CT
Sbjct: 56 KERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT 115
Query: 134 SSIVHLCAISLDRYWSITQAIEYNL---KRTPRRIKAIIITVWVISAVISFPPLISIEKK 190
+SI++LCAIS+DRY ++ + Y + + RR+ +I VWV++ +S P L
Sbjct: 116 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT 175
Query: 191 GGGGGPQPAEPR-CEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRR 249
G +P C I++ +VI S + SF+ P + +LVY RIY + K+R
Sbjct: 176 G--------DPTVCSISNPD-FVIYSSVVSFYLPFGVTVLVYARIYVVLKQR-------- 218
Query: 250 GPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGA-PGEPAPAGPRDTDALDL 308
RR L + S Q N PG P D L+L
Sbjct: 219 -------------RRKRILTRQNS-------------QCNSVRPGFPQQTLSPDPAHLEL 252
Query: 309 EESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEER 368
+ S GP ERG G+ + + +P R AT +
Sbjct: 253 KRYYSICQDTALGGPGFQERG----GELKREEKTRNSLMPLREKKATQM----------- 297
Query: 369 VGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLT--AVGCSVPRTLFKFF 426
+A+V+G F+VCW PFF T+ L C V L+
Sbjct: 298 ----------------------VAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSAT 335
Query: 427 FWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456
W GY NS+LNPVIYT FN +FR+AF KIL
Sbjct: 336 TWLGYVNSALNPVIYTTFNIEFRKAFLKIL 365
>gi|194018562 histamine receptor H3 [Homo sapiens]
Length = 445
Score = 176 bits (447), Expect = 3e-44
Identities = 130/441 (29%), Positives = 202/441 (45%), Gaps = 43/441 (9%)
Query: 30 GTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVS 89
G A GGAR +S T L L LL++ TV GN LV++A +L+ N FL++
Sbjct: 18 GEAAAAGGARG--FSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLN 75
Query: 90 LASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWS 149
LA +D LV IP + + G W FG+ C+++L +D L CTSS ++ IS DR+ S
Sbjct: 76 LAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLS 135
Query: 150 ITQAIEYNLKR-TPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQ 208
+T+A+ Y ++ RR ++ VWV++ ++ P ++S E GG E
Sbjct: 136 VTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYN 195
Query: 209 KWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGL 268
+++I++ FF P L + + IY +RRTR+ G A P E +P+
Sbjct: 196 WYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRL--RLDGAREAAGPEPPPEAQPSPP 253
Query: 269 GPERSAG---PGGAEAEPL------PTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAER 319
P G G EA PL + GE G ++ SSS +
Sbjct: 254 PPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRG 313
Query: 320 PPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKAS-RWR 378
PR +RG + P A+ E+R+ S R
Sbjct: 314 TERPRSLKRGSK--------------------PSASSASL------EKRMKMVSQSFTQR 347
Query: 379 GRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV--GCSVPRTLFKFFFWFGYCNSSL 436
R +R+++ LAV++ +F +CW P+ + A G VP ++ FW + NS++
Sbjct: 348 FRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAV 407
Query: 437 NPVIYTIFNHDFRRAFKKILC 457
NPV+Y + +H FRRAF K+LC
Sbjct: 408 NPVLYPLCHHSFRRAFTKLLC 428
>gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens]
Length = 460
Score = 169 bits (428), Expect = 5e-42
Identities = 119/430 (27%), Positives = 191/430 (44%), Gaps = 43/430 (10%)
Query: 56 GLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWY 115
GLL L TV GN+LV+I+ + LK N FL+SLA AD+++ T + +MG+W
Sbjct: 33 GLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWA 92
Query: 116 FGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVI 175
G C+++LALD + +S+++L IS DRY+S+T+ + Y KRTPRR +I W++
Sbjct: 93 LGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLV 152
Query: 176 SAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIY 235
S V+ P ++ + G + + Q + + +F+ P +M +Y RIY
Sbjct: 153 SFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIY 212
Query: 236 QIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEP 295
+ + R R + +G + + G GG + GA G P
Sbjct: 213 RETENRARELAALQGSE--------------------TPGKGGGSSSSSERSQPGAEGSP 252
Query: 296 -APAG--------PRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDS 346
P G PR A +E D P + + V P
Sbjct: 253 ETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQ 312
Query: 347 LPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTF----------VLAVVIG 396
P + P + T + R A K + RG++ KR TF L+ ++
Sbjct: 313 APTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILL 372
Query: 397 VFVVCWFPFFFTYTLTAVGCS--VPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFK- 453
F++ W P+ L + C VP TL++ +W Y NS++NP+ Y + N FR F+
Sbjct: 373 AFILTWTPYNI-MVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRL 431
Query: 454 KILCRGDRKR 463
+LCR D++R
Sbjct: 432 LLLCRWDKRR 441
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 164 bits (416), Expect = 1e-40
Identities = 80/220 (36%), Positives = 137/220 (62%), Gaps = 7/220 (3%)
Query: 25 NASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQN 84
NA++ G + + +++ + G +L + GN+LVI++V +R L+ P N
Sbjct: 22 NANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTN 81
Query: 85 LFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISL 144
F+V+LA AD+L++ V+PFS A EV+GYW G+ +C+I+ A+DVL CT+SI+ LCAIS+
Sbjct: 82 YFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISI 141
Query: 145 DRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPR-C 203
DRY + +++Y T R+ +++VWV+S VIS PL+ G P P + + C
Sbjct: 142 DRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLL------GWKEPAPNDDKEC 195
Query: 204 EINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTR 243
+ ++ +Y + S +GSF+ P +++++Y R+Y +AKR T+
Sbjct: 196 GVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTK 235
Score = 78.2 bits (191), Expect = 1e-14
Identities = 37/87 (42%), Positives = 55/87 (63%), Gaps = 5/87 (5%)
Query: 382 NREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSV--PRTLFKFFFWFGYCNSSLNPV 439
+REK+ L +V+G+F++CW PFF L ++ ++ P +FK FW GY NS LNP+
Sbjct: 287 SREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPI 346
Query: 440 IYTIFNHDFRRAFKKIL---CRGDRKR 463
IY + +F+RAF +IL CRG +R
Sbjct: 347 IYPCSSKEFKRAFVRILGCQCRGRGRR 373
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 162 bits (410), Expect = 6e-40
Identities = 93/242 (38%), Positives = 132/242 (54%), Gaps = 17/242 (7%)
Query: 21 PDAGNASW----NGTEAPGGGARATPYSLQVTLTL------VCLAGLLMLLTVFGNVLVI 70
P AG+ +W N + AP A Y Q +++L V L L+ L T N VI
Sbjct: 12 PPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVI 71
Query: 71 IAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVL 130
V+ +R L P N + SLA D+LV+ LV+P S V G W G+ C+ +L+ D+
Sbjct: 72 ATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDIT 131
Query: 131 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKK 190
CT+SI+HLC I+LDRYW+IT A+EY+ KRTP+R +I VWV S IS PP + K
Sbjct: 132 CCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAK 191
Query: 191 GGGGGPQPAEPRCEIN-DQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRR-TRVPPSR 248
+ C +N D Y + S +G+F+ P L++I +Y RIY A+ R + P+R
Sbjct: 192 A-----EEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNR 246
Query: 249 RG 250
G
Sbjct: 247 TG 248
Score = 77.8 bits (190), Expect = 2e-14
Identities = 35/92 (38%), Positives = 53/92 (57%), Gaps = 3/92 (3%)
Query: 368 RVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV---GCSVPRTLFK 424
RV A + + RE++ T L +++G F+VCW PFF + + C +F
Sbjct: 293 RVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFD 352
Query: 425 FFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456
FF W GY NS +NP+IYT+ N DF++AF K++
Sbjct: 353 FFTWLGYLNSLINPIIYTMSNEDFKQAFHKLI 384
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 161 bits (407), Expect = 1e-39
Identities = 90/233 (38%), Positives = 132/233 (56%), Gaps = 8/233 (3%)
Query: 19 LQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRA 78
L +A N S N TE T +L+++L +V ++ L TV N V+ + +R
Sbjct: 11 LPQEASNRSLNATETSEAWDPRTLQALKISLAVVL--SVITLATVLSNAFVLTTILLTRK 68
Query: 79 LKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVH 138
L P N + SLA+ D+LV+ LV+P S+A + W FG+ C+I+L+ D+ CT+SI+H
Sbjct: 69 LHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILH 128
Query: 139 LCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQP 198
LC I+LDRYW+IT A+EY+ +RT +I VW IS IS PPL + K Q
Sbjct: 129 LCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKA-----QE 183
Query: 199 AEPRCEIN-DQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRG 250
C +N Q Y I S G+F+ P +++I++Y RIY+ A+ R PPS G
Sbjct: 184 EMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYG 236
Score = 85.1 bits (209), Expect = 1e-16
Identities = 34/77 (44%), Positives = 52/77 (67%), Gaps = 3/77 (3%)
Query: 383 REKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV---GCSVPRTLFKFFFWFGYCNSSLNPV 439
RE++ T +L +++G F++CW PFF + + C + LF FF W GY NS +NP+
Sbjct: 295 RERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPI 354
Query: 440 IYTIFNHDFRRAFKKIL 456
IYT+FN +FR+AF+KI+
Sbjct: 355 IYTVFNEEFRQAFQKIV 371
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 158 bits (400), Expect = 9e-39
Identities = 90/226 (39%), Positives = 136/226 (60%), Gaps = 19/226 (8%)
Query: 23 AGNAS--WNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALK 80
+GNAS N T+ P P ++ + L + G L+L V GN+LVI++V R L
Sbjct: 5 SGNASDSSNCTQPPA------PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLH 58
Query: 81 APQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLC 140
+ + ++V+LA AD+L+ + V+PFS EV+GYW FG+ +C I+ A+DVL CT+SI+ LC
Sbjct: 59 SVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLC 118
Query: 141 AISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPA- 199
IS+DRY ++ + Y T RR ++ VW +S VIS PL G QPA
Sbjct: 119 IISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLF--------GWRQPAP 170
Query: 200 --EPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTR 243
E C+IN++ YV+ S +GSF+ P I++++Y R+Y +AKR +R
Sbjct: 171 EDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESR 216
Score = 71.2 bits (173), Expect = 2e-12
Identities = 32/80 (40%), Positives = 48/80 (60%), Gaps = 8/80 (10%)
Query: 382 NREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVP-----RTLFKFFFWFGYCNSSL 436
+REK+ L +V+G FV+CW PFF + +G P T+FK FW GY NS +
Sbjct: 265 SREKKAAKTLGIVVGCFVLCWLPFFL---VMPIGSFFPDFKPSETVFKIVFWLGYLNSCI 321
Query: 437 NPVIYTIFNHDFRRAFKKIL 456
NP+IY + +F++AF+ +L
Sbjct: 322 NPIIYPCSSQEFKKAFQNVL 341
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 158 bits (400), Expect = 9e-39
Identities = 90/226 (39%), Positives = 136/226 (60%), Gaps = 19/226 (8%)
Query: 23 AGNAS--WNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALK 80
+GNAS N T+ P P ++ + L + G L+L V GN+LVI++V R L
Sbjct: 5 SGNASDSSNCTQPPA------PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLH 58
Query: 81 APQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLC 140
+ + ++V+LA AD+L+ + V+PFS EV+GYW FG+ +C I+ A+DVL CT+SI+ LC
Sbjct: 59 SVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLC 118
Query: 141 AISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPA- 199
IS+DRY ++ + Y T RR ++ VW +S VIS PL G QPA
Sbjct: 119 IISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLF--------GWRQPAP 170
Query: 200 --EPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTR 243
E C+IN++ YV+ S +GSF+ P I++++Y R+Y +AKR +R
Sbjct: 171 EDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESR 216
Score = 71.2 bits (173), Expect = 2e-12
Identities = 32/80 (40%), Positives = 48/80 (60%), Gaps = 8/80 (10%)
Query: 382 NREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVP-----RTLFKFFFWFGYCNSSL 436
+REK+ L +V+G FV+CW PFF + +G P T+FK FW GY NS +
Sbjct: 265 SREKKAAKTLGIVVGCFVLCWLPFFL---VMPIGSFFPDFKPSETVFKIVFWLGYLNSCI 321
Query: 437 NPVIYTIFNHDFRRAFKKIL 456
NP+IY + +F++AF+ +L
Sbjct: 322 NPIIYPCSSQEFKKAFQNVL 341
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 158 bits (400), Expect = 9e-39
Identities = 90/226 (39%), Positives = 136/226 (60%), Gaps = 19/226 (8%)
Query: 23 AGNAS--WNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALK 80
+GNAS N T+ P P ++ + L + G L+L V GN+LVI++V R L
Sbjct: 5 SGNASDSSNCTQPPA------PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLH 58
Query: 81 APQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLC 140
+ + ++V+LA AD+L+ + V+PFS EV+GYW FG+ +C I+ A+DVL CT+SI+ LC
Sbjct: 59 SVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLC 118
Query: 141 AISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPA- 199
IS+DRY ++ + Y T RR ++ VW +S VIS PL G QPA
Sbjct: 119 IISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLF--------GWRQPAP 170
Query: 200 --EPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTR 243
E C+IN++ YV+ S +GSF+ P I++++Y R+Y +AKR +R
Sbjct: 171 EDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESR 216
Score = 71.2 bits (173), Expect = 2e-12
Identities = 32/80 (40%), Positives = 48/80 (60%), Gaps = 8/80 (10%)
Query: 382 NREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVP-----RTLFKFFFWFGYCNSSL 436
+REK+ L +V+G FV+CW PFF + +G P T+FK FW GY NS +
Sbjct: 265 SREKKAAKTLGIVVGCFVLCWLPFFL---VMPIGSFFPDFKPSETVFKIVFWLGYLNSCI 321
Query: 437 NPVIYTIFNHDFRRAFKKIL 456
NP+IY + +F++AF+ +L
Sbjct: 322 NPIIYPCSSQEFKKAFQNVL 341
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 158 bits (400), Expect = 9e-39
Identities = 90/226 (39%), Positives = 136/226 (60%), Gaps = 19/226 (8%)
Query: 23 AGNAS--WNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALK 80
+GNAS N T+ P P ++ + L + G L+L V GN+LVI++V R L
Sbjct: 5 SGNASDSSNCTQPPA------PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLH 58
Query: 81 APQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLC 140
+ + ++V+LA AD+L+ + V+PFS EV+GYW FG+ +C I+ A+DVL CT+SI+ LC
Sbjct: 59 SVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLC 118
Query: 141 AISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPA- 199
IS+DRY ++ + Y T RR ++ VW +S VIS PL G QPA
Sbjct: 119 IISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLF--------GWRQPAP 170
Query: 200 --EPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTR 243
E C+IN++ YV+ S +GSF+ P I++++Y R+Y +AKR +R
Sbjct: 171 EDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESR 216
Score = 71.2 bits (173), Expect = 2e-12
Identities = 32/80 (40%), Positives = 48/80 (60%), Gaps = 8/80 (10%)
Query: 382 NREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVP-----RTLFKFFFWFGYCNSSL 436
+REK+ L +V+G FV+CW PFF + +G P T+FK FW GY NS +
Sbjct: 265 SREKKAAKTLGIVVGCFVLCWLPFFL---VMPIGSFFPDFKPSETVFKIVFWLGYLNSCI 321
Query: 437 NPVIYTIFNHDFRRAFKKIL 456
NP+IY + +F++AF+ +L
Sbjct: 322 NPIIYPCSSQEFKKAFQNVL 341
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 154 bits (388), Expect = 2e-37
Identities = 84/216 (38%), Positives = 133/216 (61%), Gaps = 12/216 (5%)
Query: 29 NGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLV 88
NGT A GG S Q V LA + L+ V GN+LVI++V +R L+ N F+V
Sbjct: 82 NGTAAVGG----LVVSAQGVGVGVFLAAFI-LMAVAGNLLVILSVACNRHLQTVTNYFIV 136
Query: 89 SLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYW 148
+LA AD+L++ V+PFS EV+G+W FG+A+C+++ A+DVL CT+SI+ LC IS+DRY
Sbjct: 137 NLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYV 196
Query: 149 SITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPR-CEIND 207
+ +++Y T R+ AI+ +WV++ V+S PL+ G P P + R C I +
Sbjct: 197 GVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLL------GWKEPVPPDERFCGITE 250
Query: 208 QKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTR 243
+ Y + S + SF+ P +++++Y R+Y +A+ TR
Sbjct: 251 EAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTR 286
Score = 80.1 bits (196), Expect = 4e-15
Identities = 44/118 (37%), Positives = 66/118 (55%), Gaps = 12/118 (10%)
Query: 358 GTPAAGPGEERVGAAKASRWRG-------RQNREKRFTFVLAVVIGVFVVCWFPFFFTYT 410
G G + +AK +R + +REK+ LA+V+GVFV+CWFPFFF
Sbjct: 310 GAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLP 369
Query: 411 LTAVGCSVPRT--LFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL---CRGDRKR 463
L ++ + + +FK FW GY NS +NP+IY + +F+RAF ++L CR R+R
Sbjct: 370 LGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRR 427
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 150 bits (379), Expect = 2e-36
Identities = 83/194 (42%), Positives = 117/194 (60%), Gaps = 9/194 (4%)
Query: 47 VTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSL 106
+ +TLV + L LL N+ VI+A+ T++ L P N + SLA D+LVA LV+P S+
Sbjct: 25 ICMTLVVITTLTTLL----NLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSI 80
Query: 107 ANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIK 166
VM W G CE++L++D+ CT SI+HLC I+LDRYW+IT AIEY KRT +R
Sbjct: 81 IYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAA 140
Query: 167 AIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEI-NDQKWYVISSCIGSFFAPCL 225
+I+TVW IS IS PPL + P +C I +D Y I S +G+F+ P
Sbjct: 141 LMILTVWTISIFISMPPLFWRSHR----RLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLT 196
Query: 226 IMILVYVRIYQIAK 239
+++++Y RIY AK
Sbjct: 197 LILILYYRIYHAAK 210
Score = 68.6 bits (166), Expect = 1e-11
Identities = 30/78 (38%), Positives = 48/78 (61%), Gaps = 2/78 (2%)
Query: 383 REKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGC-SVPRTLFKFFFWFGYCNSSLNPVIY 441
RE++ +L +++G F++ W PFF + + +V + F W GY NS +NP++Y
Sbjct: 285 RERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLY 344
Query: 442 TIFNHDFRRAFKKIL-CR 458
T FN DF+ AFKK++ CR
Sbjct: 345 TSFNEDFKLAFKKLIRCR 362
>gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 149 bits (375), Expect = 7e-36
Identities = 105/445 (23%), Positives = 199/445 (44%), Gaps = 28/445 (6%)
Query: 38 ARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILV 97
A +PY + +V +AG L L+T+ GN+LV++++ +R L+ N FL SLA AD+++
Sbjct: 13 ALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLII 72
Query: 98 ATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYN 157
+ V+GYW G C+++LALD + +S+++L IS DRY+ +T+ + Y
Sbjct: 73 GVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYP 132
Query: 158 LKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCI 217
+KRT + +I WV+S ++ P ++ + G + E + + I
Sbjct: 133 VKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAI 192
Query: 218 GSFFAPCLIMILVYVRIYQIAKRRTRV----PPSRRGPDAVAAPPGGTERRPNGLGPERS 273
+F+ P +IM ++Y I + +K R + P + + P + + G + N P
Sbjct: 193 AAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSD 252
Query: 274 AG-------PGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRP 326
G G A +P+ N GE + T + + D +
Sbjct: 253 DGLEHNKIQNGKAPRDPVTE--NCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVST 310
Query: 327 ERGPRGKGKARASQVKPGDSLPRRG---PGATGIGTPAA----GPGEERVGAAKA----- 374
G ++ + ++ G P+ P T + + G ++ + A K
Sbjct: 311 SLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTK 370
Query: 375 --SRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTL-TAVGCSVPRTLFKFFFWFGY 431
++ + +REK+ T + ++ F++ W P+ + T +P T++ +W Y
Sbjct: 371 QPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCY 430
Query: 432 CNSSLNPVIYTIFNHDFRRAFKKIL 456
NS++NP Y + N F++ FK +L
Sbjct: 431 INSTINPACYALCNATFKKTFKHLL 455
>gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 149 bits (375), Expect = 7e-36
Identities = 105/445 (23%), Positives = 199/445 (44%), Gaps = 28/445 (6%)
Query: 38 ARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILV 97
A +PY + +V +AG L L+T+ GN+LV++++ +R L+ N FL SLA AD+++
Sbjct: 13 ALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLII 72
Query: 98 ATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYN 157
+ V+GYW G C+++LALD + +S+++L IS DRY+ +T+ + Y
Sbjct: 73 GVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYP 132
Query: 158 LKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCI 217
+KRT + +I WV+S ++ P ++ + G + E + + I
Sbjct: 133 VKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAI 192
Query: 218 GSFFAPCLIMILVYVRIYQIAKRRTRV----PPSRRGPDAVAAPPGGTERRPNGLGPERS 273
+F+ P +IM ++Y I + +K R + P + + P + + G + N P
Sbjct: 193 AAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSD 252
Query: 274 AG-------PGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRP 326
G G A +P+ N GE + T + + D +
Sbjct: 253 DGLEHNKIQNGKAPRDPVTE--NCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVST 310
Query: 327 ERGPRGKGKARASQVKPGDSLPRRG---PGATGIGTPAA----GPGEERVGAAKA----- 374
G ++ + ++ G P+ P T + + G ++ + A K
Sbjct: 311 SLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTK 370
Query: 375 --SRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTL-TAVGCSVPRTLFKFFFWFGY 431
++ + +REK+ T + ++ F++ W P+ + T +P T++ +W Y
Sbjct: 371 QPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCY 430
Query: 432 CNSSLNPVIYTIFNHDFRRAFKKIL 456
NS++NP Y + N F++ FK +L
Sbjct: 431 INSTINPACYALCNATFKKTFKHLL 455
>gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 149 bits (375), Expect = 7e-36
Identities = 105/445 (23%), Positives = 199/445 (44%), Gaps = 28/445 (6%)
Query: 38 ARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILV 97
A +PY + +V +AG L L+T+ GN+LV++++ +R L+ N FL SLA AD+++
Sbjct: 13 ALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLII 72
Query: 98 ATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYN 157
+ V+GYW G C+++LALD + +S+++L IS DRY+ +T+ + Y
Sbjct: 73 GVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYP 132
Query: 158 LKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCI 217
+KRT + +I WV+S ++ P ++ + G + E + + I
Sbjct: 133 VKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAI 192
Query: 218 GSFFAPCLIMILVYVRIYQIAKRRTRV----PPSRRGPDAVAAPPGGTERRPNGLGPERS 273
+F+ P +IM ++Y I + +K R + P + + P + + G + N P
Sbjct: 193 AAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSD 252
Query: 274 AG-------PGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRP 326
G G A +P+ N GE + T + + D +
Sbjct: 253 DGLEHNKIQNGKAPRDPVTE--NCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVST 310
Query: 327 ERGPRGKGKARASQVKPGDSLPRRG---PGATGIGTPAA----GPGEERVGAAKA----- 374
G ++ + ++ G P+ P T + + G ++ + A K
Sbjct: 311 SLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTK 370
Query: 375 --SRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTL-TAVGCSVPRTLFKFFFWFGY 431
++ + +REK+ T + ++ F++ W P+ + T +P T++ +W Y
Sbjct: 371 QPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCY 430
Query: 432 CNSSLNPVIYTIFNHDFRRAFKKIL 456
NS++NP Y + N F++ FK +L
Sbjct: 431 INSTINPACYALCNATFKKTFKHLL 455
>gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 149 bits (375), Expect = 7e-36
Identities = 105/445 (23%), Positives = 199/445 (44%), Gaps = 28/445 (6%)
Query: 38 ARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILV 97
A +PY + +V +AG L L+T+ GN+LV++++ +R L+ N FL SLA AD+++
Sbjct: 13 ALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLII 72
Query: 98 ATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYN 157
+ V+GYW G C+++LALD + +S+++L IS DRY+ +T+ + Y
Sbjct: 73 GVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYP 132
Query: 158 LKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCI 217
+KRT + +I WV+S ++ P ++ + G + E + + I
Sbjct: 133 VKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAI 192
Query: 218 GSFFAPCLIMILVYVRIYQIAKRRTRV----PPSRRGPDAVAAPPGGTERRPNGLGPERS 273
+F+ P +IM ++Y I + +K R + P + + P + + G + N P
Sbjct: 193 AAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSD 252
Query: 274 AG-------PGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRP 326
G G A +P+ N GE + T + + D +
Sbjct: 253 DGLEHNKIQNGKAPRDPVTE--NCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVST 310
Query: 327 ERGPRGKGKARASQVKPGDSLPRRG---PGATGIGTPAA----GPGEERVGAAKA----- 374
G ++ + ++ G P+ P T + + G ++ + A K
Sbjct: 311 SLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTK 370
Query: 375 --SRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTL-TAVGCSVPRTLFKFFFWFGY 431
++ + +REK+ T + ++ F++ W P+ + T +P T++ +W Y
Sbjct: 371 QPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCY 430
Query: 432 CNSSLNPVIYTIFNHDFRRAFKKIL 456
NS++NP Y + N F++ FK +L
Sbjct: 431 INSTINPACYALCNATFKKTFKHLL 455
>gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 149 bits (375), Expect = 7e-36
Identities = 105/445 (23%), Positives = 199/445 (44%), Gaps = 28/445 (6%)
Query: 38 ARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILV 97
A +PY + +V +AG L L+T+ GN+LV++++ +R L+ N FL SLA AD+++
Sbjct: 13 ALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLII 72
Query: 98 ATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYN 157
+ V+GYW G C+++LALD + +S+++L IS DRY+ +T+ + Y
Sbjct: 73 GVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYP 132
Query: 158 LKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCI 217
+KRT + +I WV+S ++ P ++ + G + E + + I
Sbjct: 133 VKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAI 192
Query: 218 GSFFAPCLIMILVYVRIYQIAKRRTRV----PPSRRGPDAVAAPPGGTERRPNGLGPERS 273
+F+ P +IM ++Y I + +K R + P + + P + + G + N P
Sbjct: 193 AAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSD 252
Query: 274 AG-------PGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRP 326
G G A +P+ N GE + T + + D +
Sbjct: 253 DGLEHNKIQNGKAPRDPVTE--NCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVST 310
Query: 327 ERGPRGKGKARASQVKPGDSLPRRG---PGATGIGTPAA----GPGEERVGAAKA----- 374
G ++ + ++ G P+ P T + + G ++ + A K
Sbjct: 311 SLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTK 370
Query: 375 --SRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTL-TAVGCSVPRTLFKFFFWFGY 431
++ + +REK+ T + ++ F++ W P+ + T +P T++ +W Y
Sbjct: 371 QPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCY 430
Query: 432 CNSSLNPVIYTIFNHDFRRAFKKIL 456
NS++NP Y + N F++ FK +L
Sbjct: 431 INSTINPACYALCNATFKKTFKHLL 455
>gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 149 bits (375), Expect = 7e-36
Identities = 105/445 (23%), Positives = 199/445 (44%), Gaps = 28/445 (6%)
Query: 38 ARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILV 97
A +PY + +V +AG L L+T+ GN+LV++++ +R L+ N FL SLA AD+++
Sbjct: 13 ALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLII 72
Query: 98 ATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYN 157
+ V+GYW G C+++LALD + +S+++L IS DRY+ +T+ + Y
Sbjct: 73 GVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYP 132
Query: 158 LKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCI 217
+KRT + +I WV+S ++ P ++ + G + E + + I
Sbjct: 133 VKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAI 192
Query: 218 GSFFAPCLIMILVYVRIYQIAKRRTRV----PPSRRGPDAVAAPPGGTERRPNGLGPERS 273
+F+ P +IM ++Y I + +K R + P + + P + + G + N P
Sbjct: 193 AAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSD 252
Query: 274 AG-------PGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRP 326
G G A +P+ N GE + T + + D +
Sbjct: 253 DGLEHNKIQNGKAPRDPVTE--NCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVST 310
Query: 327 ERGPRGKGKARASQVKPGDSLPRRG---PGATGIGTPAA----GPGEERVGAAKA----- 374
G ++ + ++ G P+ P T + + G ++ + A K
Sbjct: 311 SLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTK 370
Query: 375 --SRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTL-TAVGCSVPRTLFKFFFWFGY 431
++ + +REK+ T + ++ F++ W P+ + T +P T++ +W Y
Sbjct: 371 QPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCY 430
Query: 432 CNSSLNPVIYTIFNHDFRRAFKKIL 456
NS++NP Y + N F++ FK +L
Sbjct: 431 INSTINPACYALCNATFKKTFKHLL 455
>gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 149 bits (375), Expect = 7e-36
Identities = 105/445 (23%), Positives = 199/445 (44%), Gaps = 28/445 (6%)
Query: 38 ARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILV 97
A +PY + +V +AG L L+T+ GN+LV++++ +R L+ N FL SLA AD+++
Sbjct: 13 ALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLII 72
Query: 98 ATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYN 157
+ V+GYW G C+++LALD + +S+++L IS DRY+ +T+ + Y
Sbjct: 73 GVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYP 132
Query: 158 LKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCI 217
+KRT + +I WV+S ++ P ++ + G + E + + I
Sbjct: 133 VKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAI 192
Query: 218 GSFFAPCLIMILVYVRIYQIAKRRTRV----PPSRRGPDAVAAPPGGTERRPNGLGPERS 273
+F+ P +IM ++Y I + +K R + P + + P + + G + N P
Sbjct: 193 AAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSD 252
Query: 274 AG-------PGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRP 326
G G A +P+ N GE + T + + D +
Sbjct: 253 DGLEHNKIQNGKAPRDPVTE--NCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVST 310
Query: 327 ERGPRGKGKARASQVKPGDSLPRRG---PGATGIGTPAA----GPGEERVGAAKA----- 374
G ++ + ++ G P+ P T + + G ++ + A K
Sbjct: 311 SLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTK 370
Query: 375 --SRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTL-TAVGCSVPRTLFKFFFWFGY 431
++ + +REK+ T + ++ F++ W P+ + T +P T++ +W Y
Sbjct: 371 QPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCY 430
Query: 432 CNSSLNPVIYTIFNHDFRRAFKKIL 456
NS++NP Y + N F++ FK +L
Sbjct: 431 INSTINPACYALCNATFKKTFKHLL 455
>gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 149 bits (375), Expect = 7e-36
Identities = 105/445 (23%), Positives = 199/445 (44%), Gaps = 28/445 (6%)
Query: 38 ARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILV 97
A +PY + +V +AG L L+T+ GN+LV++++ +R L+ N FL SLA AD+++
Sbjct: 13 ALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLII 72
Query: 98 ATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYN 157
+ V+GYW G C+++LALD + +S+++L IS DRY+ +T+ + Y
Sbjct: 73 GVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYP 132
Query: 158 LKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCI 217
+KRT + +I WV+S ++ P ++ + G + E + + I
Sbjct: 133 VKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAI 192
Query: 218 GSFFAPCLIMILVYVRIYQIAKRRTRV----PPSRRGPDAVAAPPGGTERRPNGLGPERS 273
+F+ P +IM ++Y I + +K R + P + + P + + G + N P
Sbjct: 193 AAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSD 252
Query: 274 AG-------PGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRP 326
G G A +P+ N GE + T + + D +
Sbjct: 253 DGLEHNKIQNGKAPRDPVTE--NCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVST 310
Query: 327 ERGPRGKGKARASQVKPGDSLPRRG---PGATGIGTPAA----GPGEERVGAAKA----- 374
G ++ + ++ G P+ P T + + G ++ + A K
Sbjct: 311 SLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTK 370
Query: 375 --SRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTL-TAVGCSVPRTLFKFFFWFGY 431
++ + +REK+ T + ++ F++ W P+ + T +P T++ +W Y
Sbjct: 371 QPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCY 430
Query: 432 CNSSLNPVIYTIFNHDFRRAFKKIL 456
NS++NP Y + N F++ FK +L
Sbjct: 431 INSTINPACYALCNATFKKTFKHLL 455
>gi|149158709 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 148 bits (373), Expect = 1e-35
Identities = 130/475 (27%), Positives = 206/475 (43%), Gaps = 63/475 (13%)
Query: 37 GARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADIL 96
G + T S Q+ + LV + + L+TV N+LV+ AV + R L NL++VSL+ AD++
Sbjct: 17 GNKTTMASPQL-MPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLI 75
Query: 97 VATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEY 156
V +V+P ++ +M W G+ C +L++D + T+SI + + +DRY S+ Q + Y
Sbjct: 76 VGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRY 135
Query: 157 NLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPA----EPRCEIN--DQKW 210
RT R A I+ W +S + P L G Q E +CE + D W
Sbjct: 136 LKYRTKTRASATILGAWFLSFLWVIPIL------GWNHFMQQTSVRREDKCETDFYDVTW 189
Query: 211 YVISSCIGSFFAPCLIMILVYVRIYQIAKRR-------TRVPPSRRGPDAVAAPPGGTER 263
+ + + I +F+ P L+M+ Y +IY+ ++ R PS P G +
Sbjct: 190 FKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAK 249
Query: 264 RPNGLGP-----ERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALD----------- 307
+P P + GG P+Q P D +D
Sbjct: 250 KPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVH 309
Query: 308 ---LEESSSSDH--AERPPGP-RRPERGPRGKGKARASQVKP-GDSLPRRGPGATGIGTP 360
E SS D+ R G + E+G G + S+ + GDS +
Sbjct: 310 MQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTET 369
Query: 361 AAGPGEERVGAA----------KASRWRGRQ-------NREKRFTFVLAVVIGVFVVCWF 403
A G G+ R G+ K R RQ NRE++ L ++ F++CW
Sbjct: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWI 429
Query: 404 PFFFTYTLTAV--GCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456
P+F + + A C L F W GY NS+LNP+IY + N +F++ FK+IL
Sbjct: 430 PYFIFFMVIAFCKNC-CNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.140 0.444
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,548,052
Number of Sequences: 37866
Number of extensions: 1288567
Number of successful extensions: 16569
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 700
Number of HSP's successfully gapped in prelim test: 1004
Number of HSP's that attempted gapping in prelim test: 7741
Number of HSP's gapped (non-prelim): 5287
length of query: 465
length of database: 18,247,518
effective HSP length: 106
effective length of query: 359
effective length of database: 14,233,722
effective search space: 5109906198
effective search space used: 5109906198
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.