Search of human proteins with 194353964

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194353964 coiled-coil domain containing 157 [Homo sapiens]
         (752 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194353964 coiled-coil domain containing 157 [Homo sapiens]        1486   0.0  
gi|221139761 zinc finger protein 853 [Homo sapiens]                    91   5e-18
gi|21735548 centrosomal protein 2 [Homo sapiens]                       89   2e-17
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                85   2e-16
gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]        82   2e-15
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        80   5e-15
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        80   5e-15
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         80   5e-15
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         80   5e-15
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         80   5e-15
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         80   5e-15
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         80   5e-15
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         80   5e-15
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           77   4e-14
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           77   4e-14
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           77   4e-14
gi|148746195 trichohyalin [Homo sapiens]                               77   4e-14
gi|58530840 desmoplakin isoform I [Homo sapiens]                       76   1e-13
gi|205277396 dynactin 1 isoform 4 [Homo sapiens]                       75   2e-13
gi|205277392 dynactin 1 isoform 3 [Homo sapiens]                       75   2e-13
gi|13259508 dynactin 1 isoform 2 [Homo sapiens]                        75   2e-13
gi|13259510 dynactin 1 isoform 1 [Homo sapiens]                        75   2e-13
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    75   3e-13
gi|38044112 restin isoform b [Homo sapiens]                            75   3e-13
gi|4506751 restin isoform a [Homo sapiens]                             75   3e-13
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    75   3e-13
gi|64085252 hypothetical protein LOC145508 [Homo sapiens]              74   4e-13
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    74   4e-13
gi|148762940 DVL-binding protein DAPLE [Homo sapiens]                  74   5e-13
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    74   5e-13

>gi|194353964 coiled-coil domain containing 157 [Homo sapiens]
          Length = 752

 Score = 1486 bits (3846), Expect = 0.0
 Identities = 752/752 (100%), Positives = 752/752 (100%)

Query: 1   MAHLLGSQACMESLRTDLTDLQGAIVDVFSRAGPVRFPSWKFPDRMACDLDMVALLEHYD 60
           MAHLLGSQACMESLRTDLTDLQGAIVDVFSRAGPVRFPSWKFPDRMACDLDMVALLEHYD
Sbjct: 1   MAHLLGSQACMESLRTDLTDLQGAIVDVFSRAGPVRFPSWKFPDRMACDLDMVALLEHYD 60

Query: 61  HVPGDPEFTQLSHAVLLELVIDRLLLLLQSCMSYLENLGSEQMMPPAQAAGPCMSVGLTV 120
           HVPGDPEFTQLSHAVLLELVIDRLLLLLQSCMSYLENLGSEQMMPPAQAAGPCMSVGLTV
Sbjct: 61  HVPGDPEFTQLSHAVLLELVIDRLLLLLQSCMSYLENLGSEQMMPPAQAAGPCMSVGLTV 120

Query: 121 RRFWDSLLRLGTLHQQPLPQKGANQRETPTSKPTTKGEPARSPEYLTTKLIKPSSPVLGL 180
           RRFWDSLLRLGTLHQQPLPQKGANQRETPTSKPTTKGEPARSPEYLTTKLIKPSSPVLGL
Sbjct: 121 RRFWDSLLRLGTLHQQPLPQKGANQRETPTSKPTTKGEPARSPEYLTTKLIKPSSPVLGL 180

Query: 181 PQTCQEPESIPVRASLQFPATTFKNTRSVHSQTIETALVPCDACASVQGSLQKVGKVVIS 240
           PQTCQEPESIPVRASLQFPATTFKNTRSVHSQTIETALVPCDACASVQGSLQKVGKVVIS
Sbjct: 181 PQTCQEPESIPVRASLQFPATTFKNTRSVHSQTIETALVPCDACASVQGSLQKVGKVVIS 240

Query: 241 LCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEA 300
           LCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEA
Sbjct: 241 LCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEA 300

Query: 301 EGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATL 360
           EGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATL
Sbjct: 301 EGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATL 360

Query: 361 ERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAG 420
           ERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAG
Sbjct: 361 ERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAG 420

Query: 421 QQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRA 480
           QQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRA
Sbjct: 421 QQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRA 480

Query: 481 RVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERER 540
           RVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERER
Sbjct: 481 RVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERER 540

Query: 541 LLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENG 600
           LLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENG
Sbjct: 541 LLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENG 600

Query: 601 RLQSMLSKIREVAQQGGLKLIPQDRLWSPSSKGTQGATPPVQAKSTSPGPLGRQHLPSSR 660
           RLQSMLSKIREVAQQGGLKLIPQDRLWSPSSKGTQGATPPVQAKSTSPGPLGRQHLPSSR
Sbjct: 601 RLQSMLSKIREVAQQGGLKLIPQDRLWSPSSKGTQGATPPVQAKSTSPGPLGRQHLPSSR 660

Query: 661 TGRTLLGQPCTSPPRQPCTSPPRQPCTSPPRQPCTSPSRQPCSQPSKSLLEGVTHLDTCT 720
           TGRTLLGQPCTSPPRQPCTSPPRQPCTSPPRQPCTSPSRQPCSQPSKSLLEGVTHLDTCT
Sbjct: 661 TGRTLLGQPCTSPPRQPCTSPPRQPCTSPPRQPCTSPSRQPCSQPSKSLLEGVTHLDTCT 720

Query: 721 QNPIKVLVRLRKRLSPGRGQASSAHQPQERPM 752
           QNPIKVLVRLRKRLSPGRGQASSAHQPQERPM
Sbjct: 721 QNPIKVLVRLRKRLSPGRGQASSAHQPQERPM 752


>gi|221139761 zinc finger protein 853 [Homo sapiens]
          Length = 659

 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 85/310 (27%), Positives = 154/310 (49%), Gaps = 19/310 (6%)

Query: 243 QSQNLPSSLGQFQQLVQDS--MGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEA 300
           + Q  P    Q +QL Q    + L+  P    G+    Q +     S H + L+ +L+  
Sbjct: 95  EQQPEPQQQPQHEQLQQPQPHLELQQQPQQD-GQQQLSQLQQEKHQSVHHQELKPELQLM 153

Query: 301 EGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATL 360
             Q+  L+ Q  + +Q L+Q+Q   + Q  +++Q L + E  +QQ+  +    + +    
Sbjct: 154 HQQQQ-LQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQ 212

Query: 361 ERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQV---QQLEAQVQLLVGRLE 417
           +++L QQ+E  Q  + + QQ Q + +++    +Q  QL++Q+   QQ + Q QLL  +  
Sbjct: 213 QQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQA 272

Query: 418 GAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELR------GS 471
              QQ+     E  +++ +   + + QE LQ +Q+     L+  ++E  EL       GS
Sbjct: 273 QLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQ-QQQLQPPPLEPEEEEEVELELMPVDLGS 331

Query: 472 LDEAEAQRARVEEQLQSEREQGQCQLRAQ-----QELLQSLQREKQGLEQATTDLRLTIL 526
             E E QR  +E Q + ER+Q Q QL+ +     Q+L Q L++++Q LEQ    L LT +
Sbjct: 332 EQELEQQRQELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPV 391

Query: 527 ELERELEELK 536
           EL  + +E++
Sbjct: 392 ELGAQQQEVQ 401



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 82/368 (22%), Positives = 152/368 (41%), Gaps = 53/368 (14%)

Query: 145 QRETPTSKPTTKGEPARSPEYLTTKLIKPSSPVLGLPQTCQEPESIPVRASLQFPATTFK 204
           QRE    +   + EP + P++   + ++   P L L Q  Q+          Q      +
Sbjct: 86  QRELQLQQLEQQPEPQQQPQH---EQLQQPQPHLELQQQPQQD------GQQQLSQLQQE 136

Query: 205 NTRSVHSQTIETAL--------VPCDACASVQGSLQKVGKVVISLCQSQNLPSSLGQFQQ 256
             +SVH Q ++  L        +        Q   Q+  ++     Q Q +     Q QQ
Sbjct: 137 KHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQ 196

Query: 257 LVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLR-KQAGKLE 315
            VQ+   L+        +   +Q++ L +     +  + Q E+ + Q+  L  +Q G+L+
Sbjct: 197 QVQEQQLLQQQQEQLQQQQLLQQQEQLQQ-----QQFQQQQEQLQQQQQLLLLQQQGQLQ 251

Query: 316 QALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVE 375
           Q L Q+Q     QA+  +Q L + +   QQ L      + +    ++ L+QQ+E  Q  +
Sbjct: 252 QQLLQQQ-----QAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQ 306

Query: 376 AKAQQLQEEGERRAAAERQV------QQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTE 429
            +   L+ E E     E         Q+LE+Q Q+LE Q                    E
Sbjct: 307 LQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQ-------------------QE 347

Query: 430 LDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSE 489
           L++++ +    ++ QE LQ  ++ L +Q   L+Q+  +L  +  E  AQ+  V+ +L   
Sbjct: 348 LERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELTPV 407

Query: 490 REQGQCQL 497
           + + Q +L
Sbjct: 408 QPELQLEL 415



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 78/365 (21%), Positives = 164/365 (44%), Gaps = 58/365 (15%)

Query: 287 SKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQL 346
           S+  E    Q   +  Q+  +    G  E A +   G R  Q ++ EQ     +  + + 
Sbjct: 49  SESQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQRELQLQQLEQQPEPQQQPQHEQ 108

Query: 347 LTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLE 406
           L +           +  L+ Q++  Q  + +  QLQ+E  +        Q+L+ ++Q + 
Sbjct: 109 LQQP----------QPHLELQQQPQQDGQQQLSQLQQEKHQSV----HHQELKPELQLMH 154

Query: 407 AQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQERE 466
            Q QL   +++   Q++     +L  ++A+   +++ QE LQ +    +++   L Q++E
Sbjct: 155 QQQQLQPQQVQEQ-QRLQQQQEQLQTQQAQEQQVLQQQEQLQQQ----VQEQQLLQQQQE 209

Query: 467 ELRGSLDEAEAQRARVEEQLQSER-EQGQCQLRAQQELL---------------QSLQRE 510
           +L+      + Q  + +EQLQ ++ +Q Q QL+ QQ+LL               Q  Q +
Sbjct: 210 QLQ------QQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQ 263

Query: 511 KQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQ---IHGGRSSSVESQ 567
           +Q LEQ    L+  +L  ++E  + +++++LL    +  +  + Q   +       VE +
Sbjct: 264 QQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELE 323

Query: 568 ITCPTDSGNVTD------------HMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQ 615
           +  P D G+  +             +ERQ +   ++++ LQEE  +L+  L + ++  +Q
Sbjct: 324 L-MPVDLGSEQELEQQRQELERQQELERQQEQRQLQLK-LQEELQQLEQQLEQQQQQLEQ 381

Query: 616 GGLKL 620
             ++L
Sbjct: 382 QEVQL 386


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 100/451 (22%), Positives = 193/451 (42%), Gaps = 38/451 (8%)

Query: 204  KNTRSVHSQTIETALVPCDACASVQGSLQKVGKVVISLCQSQNLP-SSLGQFQQLVQDSM 262
            K   +   + ++ A+V   A AS  G L++  +   S  + +N    S  +  Q +Q+  
Sbjct: 1350 KENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQG 1409

Query: 263  GLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALK--- 319
             L+      +    A   + L    + VE LR Q++E E Q++  +     L   LK   
Sbjct: 1410 ELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRN 1469

Query: 320  QEQGARRRQAEEDEQCLSEWEH--------------DKQQLLTETSDLKTKMATLERELK 365
            QE   ++ Q +E E+C S  EH               ++Q+     D +T+   LE +L 
Sbjct: 1470 QEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL 1529

Query: 366  QQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAG--QQV 423
            +  +  Q +E++  Q+Q+  ++    E    +LEE   ++E Q Q L+  LEG    Q+V
Sbjct: 1530 ELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQ-QKLIKELEGQRETQRV 1588

Query: 424  CWASTELDKEKARVDSMVRHQE--SLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRAR 481
                  LD E+   +   +  +   L++    L ++L   DQE +  R  ++E + Q+  
Sbjct: 1589 ALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEH 1648

Query: 482  VEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERERL 541
            + + L+   ++   Q    Q L     R+ + LE+    ++L++ E  REL    +R+ +
Sbjct: 1649 LTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGREL--TTQRQLM 1706

Query: 542  LVAFPDLHRPTETQ---------IHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRI 592
                 +   P++ Q         I   +   VE Q     +   + D +E+Q+Q    ++
Sbjct: 1707 QERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKV 1766

Query: 593  ----RVLQEENGRLQSMLSKIREVAQQGGLK 619
                 +L +    +  +  +++E  +QG LK
Sbjct: 1767 GETSLLLSQREQEIVVLQQQLQEAREQGELK 1797



 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 114/461 (24%), Positives = 208/461 (45%), Gaps = 99/461 (21%)

Query: 227  VQGSLQKVGKVVISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRL 286
            +QG  +KVG+  + L Q +     +   QQ +Q++     L   ++     E ++ L + 
Sbjct: 1759 LQGLHRKVGETSLLLSQREQ---EIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQR 1815

Query: 287  SKHVEALRAQLEEAEGQKDGLRKQA----GKLEQA---LKQEQG---------------- 323
             + +EAL+ + ++A+GQ++ ++++A    G LEQA   LK+  G                
Sbjct: 1816 DQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEEL 1875

Query: 324  ---ARRRQAEED--------------------EQCLSE-WEHDKQQLLTETSDLKTKMAT 359
                RR QA E+                    +QC  +  EH+ +    + S L+ +   
Sbjct: 1876 AVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVL 1935

Query: 360  LER---------ELKQQRESTQAVEAKAQQLQEE-GERRAAAERQVQQLEEQVQ---QLE 406
             ER         E +  R   +A  A+A+ LQE  G+  AA + + Q L EQ +    LE
Sbjct: 1936 KERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLE 1995

Query: 407  AQVQLLVGRLEGAGQQVCWASTELDKEKARV------DSMVRHQESLQAKQRALLKQLDS 460
            A    L   L+      C A +   +E  R+      D  +R+QE +Q  Q+AL ++ + 
Sbjct: 1996 ASTATLQASLD-----ACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEE 2050

Query: 461  L--DQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQAT 518
            L   QERE+L   L+++ AQR + E  +Q ++  GQ          +  + E +GL Q+ 
Sbjct: 2051 LRHQQEREQL---LEKSLAQRVQ-ENMIQEKQNLGQ----------EREEEEIRGLHQSV 2096

Query: 519  TDLRLTILELERELEELKERERL--LVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGN 576
             +L+LT+ + E+E+ EL+E ++   L A P  H+ +  +    +  S+E ++    +   
Sbjct: 2097 RELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELER-- 2154

Query: 577  VTDHMERQVQANDIRIRVLQEE----NGRLQSMLSKIREVA 613
                  RQ +A +I  R   ++      + ++ +S ++EVA
Sbjct: 2155 -LQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVA 2194



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 89/398 (22%), Positives = 179/398 (44%), Gaps = 64/398 (16%)

Query: 276  AAEQRKDLTRLSKHVEALRAQLEEA-----------EGQKDGLRKQAGKLEQALKQEQGA 324
            A ++R+ L   + H+EA   + EEA           + +K+ ++K   KL ++  Q++ A
Sbjct: 650  AEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQK---KLSESRHQQEAA 706

Query: 325  R------RRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKA 378
                    ++A+  E+ L+    +K+ L+ E + L+ ++  +ER+ +   E  Q + +  
Sbjct: 707  TTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAK 766

Query: 379  QQLQ----EEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRL------------------ 416
            + L+    E  ++ +  E    QLE Q+Q +    +++ G +                  
Sbjct: 767  ELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQER 826

Query: 417  EGAGQQVCWA----STELDKEKARVDSMVRHQESLQAKQRA-----LLKQLDSLDQEREE 467
            + A +Q+  A     T L+++KA  +  V        K+R+     L K L+SL++E+ E
Sbjct: 827  DAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKME 886

Query: 468  LRGSLDEAEAQRARVEEQLQSEREQGQ---CQLRAQQE-----LLQSLQREKQGLEQATT 519
            L   L E + +   ++ Q + ER Q +   CQ++ + E     LL++L + ++ L  A+ 
Sbjct: 887  LEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQ 946

Query: 520  DLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTD 579
             L    L  + ++++LKE+E   +    L           R    +        S  + D
Sbjct: 947  QLER--LRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQD 1004

Query: 580  HMERQVQANDIRIR-VLQEENGRL--QSMLSKIREVAQ 614
             M+ Q Q  D++ + V Q+++ RL  Q +  K+RE  +
Sbjct: 1005 KMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQE 1042



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 95/366 (25%), Positives = 168/366 (45%), Gaps = 61/366 (16%)

Query: 275  WAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQ 334
            W  +Q +D+ R    V+ L  +L + E +K  +  +   L++ L Q Q       EE   
Sbjct: 1253 WKTQQTRDVLR--DQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQ-------EE--- 1300

Query: 335  CLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGER---RAAA 391
              S+WE  +  L +E  +L   MA+L+  L++         A+ Q+++ +GER   +AA 
Sbjct: 1301 -KSKWEGKQNSLESELMELHETMASLQSRLRR---------AELQRMEAQGERELLQAAK 1350

Query: 392  ER---QVQQLEEQVQQLEAQVQ---LLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQE 445
            E    QV+ L+  V +  AQ     +L   L  A   +   + E++ E+ R  ++    E
Sbjct: 1351 ENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGE 1410

Query: 446  SLQAKQRALLKQLDSLDQ---EREE----LRGSLDEAEAQRARVE---EQLQSEREQGQC 495
               A+ +AL + L  L Q   EREE    LRG + E E QR   +   E L  + ++   
Sbjct: 1411 LKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQ 1470

Query: 496  QLRAQQELLQSLQREKQGLEQ-----ATTDLRLTI-LELERELEELKERERLLVAFPDLH 549
            ++  QQE +Q L++ +  LE         + +LT+  E  RELE+ +E +R ++    L 
Sbjct: 1471 EVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLE 1530

Query: 550  RPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKI 609
               + Q+       +ESQ       G V D +++Q+   +     L+E + +++     I
Sbjct: 1531 LEKKDQM-------IESQ------RGQVQD-LKKQLVTLECLALELEENHHKMECQQKLI 1576

Query: 610  REVAQQ 615
            +E+  Q
Sbjct: 1577 KELEGQ 1582



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 89/394 (22%), Positives = 173/394 (43%), Gaps = 43/394 (10%)

Query: 243  QSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEG 302
            Q + L  ++ + + LV++   L  +    V R   +  + L  LS   E L + L EA+ 
Sbjct: 720  QEEVLARAVQEKEALVREKAALE-VRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQ 778

Query: 303  QKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLS-EWEHDKQQLLTETSDLKTKMATLE 361
            Q   +    G+LE  ++    A+    + + +CL  E + ++ Q   E      ++A  E
Sbjct: 779  QNSVIEVTKGQLEVQIQTVTQAKE-VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAE 837

Query: 362  RELKQQRESTQAV-EAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAG 420
            +E K   E  +A  E +  QL+E+ E+  +  +Q  +L + ++ LE +   L  RL+   
Sbjct: 838  QEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQ--ELAKALESLEREKMELEMRLKEQQ 895

Query: 421  QQVCWASTELDKEKARVDSMVRHQESLQAKQRALL--------KQLDSLDQEREELRGSL 472
             ++     + ++E+ + +S +   +    K+R  L        K+L    Q+ E LR  +
Sbjct: 896  TEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDM 955

Query: 473  DEAEAQRARVEEQLQSEREQGQCQL----RAQQELLQSLQREKQGLEQATTDLRLTILEL 528
               + +       LQ++ ++ Q +L    R  ++ L +LQ E   L Q   D       L
Sbjct: 956  KVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMD-------L 1008

Query: 529  ERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQ---- 584
            ++++E+LK +   LVA  D  R  E +        V+ ++    +   +   +ER+    
Sbjct: 1009 QKQVEDLKSQ---LVAQDDSQRLVEQE--------VQEKLRETQEYNRIQKELEREKASL 1057

Query: 585  ---VQANDIRIRVLQEENGRLQSMLSKIREVAQQ 615
               +   + R+ VLQE +   Q  LS +R+  Q+
Sbjct: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQE 1091



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 93/350 (26%), Positives = 145/350 (41%), Gaps = 51/350 (14%)

Query: 277 AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQ---ALKQEQGARRRQAEEDE 333
           AE +  +T LS  +   + Q E+ E     LR+    LE     L + + +  R A+E++
Sbjct: 279 AELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEK 338

Query: 334 QCLSEWEHDKQQLLTETSDL-------------------------KTKMATLERELKQQR 368
             L +   D  Q++ E  D                            K  TL R +  +R
Sbjct: 339 LSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRR 398

Query: 369 ESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEG-AGQQVCWAS 427
              QAV+   QQL    E     ++Q  Q EE+ + L  ++Q L G  +  AGQ V    
Sbjct: 399 R--QAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTV---- 452

Query: 428 TELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQ 487
            +L  E   VDS+ + +E LQ  +  L +QL+ L+QE   LR         R  VE QLQ
Sbjct: 453 -DLQGE---VDSLSKERELLQKAREELRQQLEVLEQEAWRLR---------RVNVELQLQ 499

Query: 488 SEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPD 547
            +  QGQ +   QQE L    RE++ L++    L     E   EL  L+E         +
Sbjct: 500 GDSAQGQKE--EQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGE 557

Query: 548 LHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQE 597
           L R  +T++    + + E  I   + S N        ++A  +++  L E
Sbjct: 558 LLRQEQTEVTAALARA-EQSIAELSSSENTLKTEVADLRAAAVKLSALNE 606



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 113/457 (24%), Positives = 178/457 (38%), Gaps = 92/457 (20%)

Query: 228  QGSLQKVGKVVISLC---QSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWA--AEQRKD 282
            Q  +QK    ++SL    ++Q +     Q Q+L +    L  LP A   R      QR+ 
Sbjct: 1450 QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509

Query: 283  LTRLSKHVEALR--------------AQLEEAEGQKDGLRKQAGKLE------------- 315
            +  L K  E  R                +E   GQ   L+KQ   LE             
Sbjct: 1510 IRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKM 1569

Query: 316  ----QALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETS---DLKTKMATLEREL---- 364
                + +K+ +G R  Q         + E   Q+L  ++S   DL++    L REL    
Sbjct: 1570 ECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERD 1629

Query: 365  ---KQQRES-----------TQAVEAKAQQLQEEGERRAAAE----RQVQQLEEQVQQLE 406
               K QRE            TQ +E + Q+L  + ER    E    RQ + LEE ++Q++
Sbjct: 1630 QEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIK 1689

Query: 407  -----------AQVQLLVGRLE-GAG----QQVCWASTEL---DKEKARVDSMVRHQESL 447
                        Q QL+  R E G G    Q+      +L   DKEK  V+    H   L
Sbjct: 1690 LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEK-EVECQQEHIHEL 1748

Query: 448  QAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSL 507
            Q  +  L +QL  L ++  E    L + E +   +++QLQ  REQG+ + ++ Q  L   
Sbjct: 1749 QELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEA 1808

Query: 508  QREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQ 567
            QR     +Q    L+    + + + E +KE+   L    +    T  + HG      E Q
Sbjct: 1809 QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHG------ELQ 1862

Query: 568  ITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQS 604
                 D       +E ++     R++ L+E  G L++
Sbjct: 1863 -----DHKEQARRLEEELAVEGRRVQALEEVLGDLRA 1894



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 89/378 (23%), Positives = 161/378 (42%), Gaps = 56/378 (14%)

Query: 281 KDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWE 340
           K+   L K  E LR QLE  E +   LR+   +L+      QG +  Q EE    + E E
Sbjct: 463 KERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERE 522

Query: 341 HDKQQLL-------TETSDLKTKMATLERE------LKQQRESTQAVEAKAQQ------- 380
             ++ L+          S+L T    LE        L+Q++    A  A+A+Q       
Sbjct: 523 RLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSS 582

Query: 381 -----LQEEGERRAAAER----------QVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCW 425
                  E  + RAAA +              L +Q+ QLE + Q +  R+E A Q    
Sbjct: 583 SENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNA 642

Query: 426 ASTELDKEKARVDSMVRHQESLQAK-QRA------LLKQLDSLDQEREELRGSLDEAEAQ 478
              +L + + R +++      L+A+ Q+A      L   L  + +E+EE++  L E+  Q
Sbjct: 643 LQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQ 702

Query: 479 RARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKER 538
           +     QL    EQ   + + Q+E+L    +EK+ L +    L + +  +ER+ ++L E+
Sbjct: 703 QEAATTQL----EQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQ 758

Query: 539 ERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDI---RIRVL 595
            + L +  +L    E+ +   +  +   ++T     G +   ++   QA ++    +R L
Sbjct: 759 LQGLSSAKEL---LESSLFEAQQQNSVIEVT----KGQLEVQIQTVTQAKEVIQGEVRCL 811

Query: 596 QEENGRLQSMLSKIREVA 613
           + E    +S   + R+ A
Sbjct: 812 KLELDTERSQAEQERDAA 829



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 71/289 (24%), Positives = 132/289 (45%), Gaps = 31/289 (10%)

Query: 281  KDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSE-- 338
            ++L    + V++ R Q+EE + QK+ L +   + +Q L  ++   R Q  ED++      
Sbjct: 1623 RELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQK--ERIQVLEDQRTRQTKI 1680

Query: 339  WEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQ--------LQEEGERRAA 390
             E D +Q+     +   ++ T +R+L Q+R       +KAQ+        +  + E+   
Sbjct: 1681 LEEDLEQIKLSLRERGRELTT-QRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE 1739

Query: 391  AERQ--------VQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVR 442
             +++          QLE+Q+Q L  +V      L    Q++     +L  ++AR    ++
Sbjct: 1740 CQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQL--QEAREQGELK 1797

Query: 443  HQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQ---LQSEREQGQCQLRA 499
             Q SLQ++     + L   DQE E L+    +A+ Q  RV+E+   LQ   EQ    L+ 
Sbjct: 1798 EQ-SLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE 1856

Query: 500  QQELLQSLQREKQGLEQATTDLRLTILELERELEEL----KERERLLVA 544
            +   LQ  + + + LE+        +  LE  L +L    +E+E+ L+A
Sbjct: 1857 RHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLA 1905



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 78/352 (22%), Positives = 152/352 (43%), Gaps = 65/352 (18%)

Query: 247  LPSSLGQFQQ---LVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQ 303
            L SSL + QQ   +++ + G   +   TV +     + ++  L   ++  R+Q   AE +
Sbjct: 769  LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQ---AEQE 825

Query: 304  KDGLRKQAGKLEQ----ALKQEQGARRRQAEEDEQCLSEWEHDK----QQLLTETSDLKT 355
            +D   +Q  + EQ    AL+Q++ A  ++     Q   +WE ++    Q+L      L+ 
Sbjct: 826  RDAAARQLAQAEQEGKTALEQQKAAHEKEVN---QLREKWEKERSWHQQELAKALESLER 882

Query: 356  KMATLERELKQQRESTQAVEAKAQ-------------QLQEEGERRAAAERQVQ---QLE 399
            +   LE  LK+Q+   +A++A+ +             QL+ E ER +  E  +Q   +L 
Sbjct: 883  EKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELA 942

Query: 400  EQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVR-HQESLQAKQR---ALL 455
            +  QQLE   Q +  +     +      T+L + +  +    R H++ L A Q    +LL
Sbjct: 943  DASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLL 1002

Query: 456  KQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQEL------------ 503
            +    L ++ E+L+  L   +  +  VE+++Q +  + Q   R Q+EL            
Sbjct: 1003 QDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLM 1062

Query: 504  ----------------LQSLQREKQGLEQATTDLRLTILELERELEELKERE 539
                             Q L   +Q +++A  + +    ++E   +E+KE+E
Sbjct: 1063 EKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKE 1114



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 73/297 (24%), Positives = 125/297 (42%), Gaps = 40/297 (13%)

Query: 279  QRKDLTRLSKHVEALRAQLEEAEGQK----------DGLRKQA-GKLEQALKQEQGARRR 327
            + ++  R+ K +E  +A L  +  +K          D +R+Q    L Q +++ QG ++ 
Sbjct: 1039 ETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE 1098

Query: 328  QAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGER 387
             + + E    E +  +   L + + L  ++       +Q R S  A EAKA QLQ    R
Sbjct: 1099 LSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ---LR 1155

Query: 388  RAAAERQVQQLEEQVQ-----QLEAQVQLLVGRLEGAGQQVCWASTEL------------ 430
              + E Q++ L  + Q     Q +AQ+  L   L+ A   VC +  EL            
Sbjct: 1156 LRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWG 1215

Query: 431  ---DKEKARVDSMVRHQESLQA-KQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQL 486
               D+  AR  S+ +    L A    A+   L  L Q+  + + + D    Q  ++EE+L
Sbjct: 1216 LEPDQNGAR--SLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERL 1273

Query: 487  ---QSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERER 540
               ++E+ Q   +L+  Q  L   Q EK   E     L   ++EL   +  L+ R R
Sbjct: 1274 TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLR 1330



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 93/385 (24%), Positives = 160/385 (41%), Gaps = 61/385 (15%)

Query: 281 KDLTRLSKHVEALRAQLEEAEGQKDGLRK--QAGKLE-QALKQEQGARRRQAEEDEQCLS 337
           ++  RL + +  L A+  E+  +   LR+  ++  LE + L+QEQ          EQ ++
Sbjct: 519 RERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIA 578

Query: 338 EWEHDKQQLLTETSDLKTKMATLE--------------RELKQQRESTQAV----EAKAQ 379
           E    +  L TE +DL+     L               ++L Q  E  Q+V    EA  Q
Sbjct: 579 ELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQ 638

Query: 380 QLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDS 439
                    A AE++ + L E+   LEAQ+Q    + E AG ++     ++ +EK  +  
Sbjct: 639 ARNALQVDLAEAEKRREALWEKNTHLEAQLQ----KAEEAGAELQADLRDIQEEKEEIQK 694

Query: 440 MV---RHQESLQAKQRALLKQLDSLDQE----REELRGSLDEAEA---QRARVEEQLQSE 489
            +   RHQ      Q A   QL+ L QE     E L  ++ E EA   ++A +E +LQ+ 
Sbjct: 695 KLSESRHQ------QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAV 748

Query: 490 REQGQCQLRAQQELLQSLQREKQGLE-------QATTDLRLTILELERELEELKERERLL 542
               Q       E LQ L   K+ LE       Q  + + +T  +LE +++ + + + ++
Sbjct: 749 ERDRQ----DLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVI 804

Query: 543 ---VAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQE-- 597
              V    L   TE         +   Q+      G     +E+Q  A++  +  L+E  
Sbjct: 805 QGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTA--LEQQKAAHEKEVNQLREKW 862

Query: 598 --ENGRLQSMLSKIREVAQQGGLKL 620
             E    Q  L+K  E  ++  ++L
Sbjct: 863 EKERSWHQQELAKALESLEREKMEL 887



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 91/403 (22%), Positives = 155/403 (38%), Gaps = 66/403 (16%)

Query: 276  AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGA----RRRQAEE 331
            AA+ +  L      +EAL A  E+  G +   + Q   L  AL+Q  G+    R   +  
Sbjct: 1149 AAQLQLRLRSTESQLEALAA--EQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGG 1206

Query: 332  DEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAA 391
             +   S W  +  Q     +    K   L   L  +  ++ A+    Q L +  + R   
Sbjct: 1207 GDSAPSVWGLEPDQ---NGARSLFKRGPLLTALSAEAVAS-ALHKLHQDLWKTQQTRDVL 1262

Query: 392  ERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVC--------WAS---------TELDKEK 434
              QVQ+LEE++   EA+   +   L+   +Q+         W            EL +  
Sbjct: 1263 RDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETM 1322

Query: 435  ARVDSMVRHQE----SLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARV-------- 482
            A + S +R  E      Q ++  L    ++L  + E L+ ++ EA AQ +          
Sbjct: 1323 ASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLR 1382

Query: 483  ---------EEQLQSEREQGQ----------CQLRAQQELLQSLQREKQGLEQATTDLRL 523
                      E+++SERE+ Q           Q +A QE L  L +     E+    LR 
Sbjct: 1383 TARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRG 1442

Query: 524  TILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMER 583
             I ELE++ E  K    LL    DL +  +           + QI       +V +H+  
Sbjct: 1443 QIQELEKQREMQKAALELLSL--DLKKRNQ------EVDLQQEQIQELEKCRSVLEHLPM 1494

Query: 584  QVQANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIPQDRL 626
             VQ  + ++ V +E+   L+      R V +   L+L  +D++
Sbjct: 1495 AVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQM 1537



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 44/182 (24%), Positives = 78/182 (42%), Gaps = 11/182 (6%)

Query: 364 LKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQV 423
           L+QQ    QA   +  +  +E ++R A    V++L+ +V Q  +  Q L  RLE  G  +
Sbjct: 27  LQQQMAENQAASWRKLKNSQEAQQRQAT--LVRKLQAKVLQYRSWCQELEKRLEATGGPI 84

Query: 424 C--WASTE---LDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQ 478
              W + E   LD+   R++   +  ESL      L   ++  D   + LR  +++    
Sbjct: 85  PQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVD 144

Query: 479 RARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILEL----ERELEE 534
            +R  ++L  +  Q Q +    +  L+        L +     R   LE+    +R+L E
Sbjct: 145 WSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLME 204

Query: 535 LK 536
           LK
Sbjct: 205 LK 206



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 74/354 (20%), Positives = 152/354 (42%), Gaps = 41/354 (11%)

Query: 206  TRSVHSQTIETALVPCDACASVQGSLQKVGKVVISLCQSQNL--PSSLGQFQQ-LVQDSM 262
            +RS+ + T  T     DAC +    L++  ++     Q Q+L     + Q QQ L Q   
Sbjct: 1991 SRSLEASTA-TLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDE 2049

Query: 263  GLRPLPAATVGRWAAEQRKDLTR--LSKHVEALRAQLEEAEGQKD------GLRKQAGKL 314
             LR            ++R+ L    L++ V+    Q ++  GQ+       GL +   +L
Sbjct: 2050 ELRH----------QQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVREL 2099

Query: 315  EQALKQEQGA----RRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRES 370
            +  L Q++      R  Q   + + L    H    +  ++  L +    L+REL++ + +
Sbjct: 2100 QLTLAQKEQEILELRETQQRNNLEALPH-SHKTSPMEEQSLKLDSLEPRLQRELERLQAA 2158

Query: 371  TQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTEL 430
             +  EA+  + +E+ +  A +  Q +     +Q++   +Q  V   +   Q++       
Sbjct: 2159 LRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRL------- 2211

Query: 431  DKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSER 490
             +++  +      +E L +       +L S  ++  +L G +   EA+ +    + QS R
Sbjct: 2212 -QDELELTRRALEKERLHSPGATSTAELGSRGEQGVQL-GEVSGVEAEPSPDGMEKQSWR 2269

Query: 491  EQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERERLLVA 544
            +    +L   Q+ +  L+ ++  L++    LR T+ ++ERE  +LK RE +  A
Sbjct: 2270 Q----RLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLK-REAMRAA 2318



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 63/284 (22%), Positives = 106/284 (37%), Gaps = 40/284 (14%)

Query: 232  QKVGKVVISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVE 291
            +K   + +SL Q++   SSL +    +Q S+               E+  +  RL   +E
Sbjct: 2171 EKAQDLALSLAQTKASVSSLQEVAMFLQASV--------------LERDSEQQRLQDELE 2216

Query: 292  ALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGAR-------RRQAEEDEQCLSEWEHDKQ 344
              R  LE+      G    A   E   + EQG +         +   D      W    +
Sbjct: 2217 LTRRALEKERLHSPGATSTA---ELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLE 2273

Query: 345  QLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQ 404
             L    + L+   + L+R   Q R + + VE + ++L+ E  R A    Q   LE     
Sbjct: 2274 HLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAA----QAGSLEISKAT 2329

Query: 405  LEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRA-LLKQLDSLDQ 463
              +  Q      +G GQ+   A    + +K  V  +++ Q +L+ KQ+   + +     +
Sbjct: 2330 ASSPTQ-----QDGRGQKNSDAKCVAELQKEVV--LLQAQLTLERKQKQDYITRSAQTSR 2382

Query: 464  EREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSL 507
            E   L  SL  +    A+  E    E E      R  + L QSL
Sbjct: 2383 ELAGLHHSLSHSLLAVAQAPEATVLEAE----TRRLDESLTQSL 2422


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 102/355 (28%), Positives = 170/355 (47%), Gaps = 50/355 (14%)

Query: 225  ASVQGSLQKVGKVVISLCQSQ-NLPSSLGQFQQLVQDSMGLRPLPA--ATVGRWAAEQRK 281
            AS+Q SL K+  +  SL Q + +L   + Q ++      G +      ATV R   E+ +
Sbjct: 732  ASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLE 791

Query: 282  DLTRLSKHV----------------EALRAQLEEAEGQKDGLRKQAGKLEQAL---KQEQ 322
            +L RL + V                EAL  QL     ++  L++Q  +L + L   +QE 
Sbjct: 792  EL-RLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQEL 850

Query: 323  GARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQ 382
               RR+A+   + L     +K+ L  E + L  ++   ERE +     T + EA   +L+
Sbjct: 851  EQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGR-----TLSEEATRLRLE 905

Query: 383  EEGERRAAAE--RQVQQLEEQVQQLEAQVQLLV-------GRLEGAGQQVCWASTE--LD 431
            +E    +  E  RQ+ QLE + +QLEA+ Q L+       G L G  QQ+     +  LD
Sbjct: 906  KEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLD 965

Query: 432  KE---KARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQS 488
            KE   +  V +    Q SL+ ++ A  + L  L +E+E    +  E EA+RA+++ QLQ 
Sbjct: 966  KELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKE---AAWRELEAERAQLQSQLQR 1022

Query: 489  EREQGQCQLRAQQELLQ----SLQREK-QGLEQATTDLRLTILELERELEELKER 538
            E+E+   +L A++E L     +LQ+E+ +GL  A ++ +  +   E E   L E+
Sbjct: 1023 EQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEK 1077



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 115/507 (22%), Positives = 204/507 (40%), Gaps = 107/507 (21%)

Query: 276  AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRR-------- 327
            +A++ +D   L     AL  QL E E ++D    +A +L++A+ + + ARR         
Sbjct: 1520 SAQRERD--ELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGV 1577

Query: 328  QAEE--DEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQE-- 383
            QAE    E+ +   E +++  L + + L+  +   E EL+  +E    ++A   +L+   
Sbjct: 1578 QAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDK 1637

Query: 384  ------------------------EGERRAAA------ERQVQQLEEQVQQLEAQV---- 409
                                    EGE + +       E Q Q L+++V  L+ QV    
Sbjct: 1638 RRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSE 1697

Query: 410  ------QLLVGRLEGAGQQVCWASTEL-DKEKARVDSMVRH------------------- 443
                  QL V RL GA  +V  +   L DK +   +++ +                    
Sbjct: 1698 VKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALT 1757

Query: 444  ---------QESLQAKQRALL---KQLDSLDQEREELRGSLDEAEAQRARVEEQLQSERE 491
                     QE L A ++AL    KQ  SL ++ + LRG + + E QR   E QLQ  RE
Sbjct: 1758 ACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLRE 1817

Query: 492  ---QGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDL 548
               Q Q    A    +Q LQ E++ L++    L+  + +LE E  E++     L      
Sbjct: 1818 VLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVA 1877

Query: 549  HRPTETQIHGGRSSSVESQITCPTDSGNVTDHM----------ERQVQANDIRIRVLQEE 598
             R T  ++   +  S E  +    + G +   +          +RQ+Q  + ++ VL++ 
Sbjct: 1878 LRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQS 1937

Query: 599  NGRLQSMLSKIREVAQQGGLKLIPQ-DRLWSPSSKGTQGATPPVQAKSTSPGPLGRQHLP 657
            +   Q     +   AQQ  L+L  + +RL S  ++  +  T   + ++      G +   
Sbjct: 1938 HSPAQ-----LEVDAQQQQLELQQEVERLRSAQAQTER--TLEARERAHRQRVRGLEEQV 1990

Query: 658  SSRTGRTLLGQPCTSPPRQPCTSPPRQ 684
            S+  G+       +S P  P + PP +
Sbjct: 1991 STLKGQLQQELRRSSAPFSPPSGPPEK 2017



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 88/382 (23%), Positives = 160/382 (41%), Gaps = 74/382 (19%)

Query: 288 KHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQ--EQGAR-RRQAEEDEQCLSEWEHDKQ 344
           +  E LR + E+ +  ++ LR+Q  +LE+  +   + GAR RR+ E   + L + E  + 
Sbjct: 617 QQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRS 676

Query: 345 QLLTETSDLKTKM--ATLERELKQQRESTQA-------------------VEAKAQQLQE 383
            L  E  +++  +  ATL+R++ Q  ++  A                   + A+   LQ+
Sbjct: 677 VLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQD 736

Query: 384 EGERRAAAERQVQQ----LEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDK-EKARVD 438
              + +A    + Q    L   V QLE +   L GR   A Q+   A  E ++ E+ R++
Sbjct: 737 SLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLE 796

Query: 439 SMVRHQ------ESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQ 492
             V  Q         +  Q AL +QL +L  ER +L+  L +   Q +  E++L+  R +
Sbjct: 797 QEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE 856

Query: 493 GQCQLRAQQELLQS-------------------------------LQREKQGLEQATTDL 521
            Q Q+ A +   +                                L+ EK+ LE +  ++
Sbjct: 857 AQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEV 916

Query: 522 RLTILELERELEELK-ERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDH 580
           +  + +LE   E+L+ E + LL+A   L      ++ G R   + +Q     D   +   
Sbjct: 917 QRQLAQLEARREQLEAEGQALLLAKETL----TGELAGLRQQIIATQEKASLDKELMAQK 972

Query: 581 M---ERQVQANDIRIRVLQEEN 599
           +   ER+ QA+    R   EE+
Sbjct: 973 LVQAEREAQASLREQRAAHEED 994



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 77/291 (26%), Positives = 129/291 (44%), Gaps = 42/291 (14%)

Query: 272  VGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQ---------------AGKLEQ 316
            V R  A+      +L    +AL    E   G+  GLR+Q               A KL Q
Sbjct: 916  VQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQ 975

Query: 317  ALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQA-VE 375
            A ++ Q + R Q    E+ L   + +K+    E   L+ + A L+ +L++++E   A +E
Sbjct: 976  AEREAQASLREQRAAHEEDLQRLQREKEAAWRE---LEAERAQLQSQLQREQEELLARLE 1032

Query: 376  AKAQQLQEE-----GERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTEL 430
            A+ ++L EE      ER         + ++ +   E++   L  +L G    +   S E+
Sbjct: 1033 AEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEM 1092

Query: 431  DKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRA----RVEEQL 486
            +++K       R  +S Q + R+ +  L S   E  +LR   +EA A  A    R++EQ 
Sbjct: 1093 ERQK-------RDAQSRQEQDRSTVNALTS---ELRDLRAQREEAAAAHAQEVRRLQEQA 1142

Query: 487  QSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKE 537
            +   +Q    LR  +EL   L+     LE A   LR  +LE +R+L E +E
Sbjct: 1143 RDLGKQRDSCLREAEELRTQLRL----LEDARDGLRRELLEAQRKLRESQE 1189



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 73/311 (23%), Positives = 132/311 (42%), Gaps = 56/311 (18%)

Query: 286 LSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGAR--------RRQAEED--EQC 335
           L+K +  +R  L  A  Q+D L+ +  ++ +AL + +  R        + +AEE   +  
Sbjct: 678 LAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDS 737

Query: 336 LSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGER-------- 387
           LS+     + L  +  DL   +A LE E    +   +  E +A   +EE ER        
Sbjct: 738 LSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQ 797

Query: 388 -----------------RAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTEL 430
                            + A E+Q+  L  +  QL+ Q+  L  +L G  Q++  A  E 
Sbjct: 798 EVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREA 857

Query: 431 DKEKARVDSMVRHQESLQAKQRALLKQLDSLDQ--------------EREELRGSLDEAE 476
            ++   ++   R +E+L  +   L  QL + ++              E+E L GSL E +
Sbjct: 858 QRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQ 917

Query: 477 AQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGL----EQATTDLRL---TILELE 529
            Q A++E + +    +GQ  L A++ L   L   +Q +    E+A+ D  L    +++ E
Sbjct: 918 RQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAE 977

Query: 530 RELEELKERER 540
           RE +     +R
Sbjct: 978 REAQASLREQR 988



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 103/431 (23%), Positives = 172/431 (39%), Gaps = 82/431 (19%)

Query: 278  EQRKDLTRLS----KHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGAR---RRQAE 330
            EQ +DL +      +  E LR QL   E  +DGLR++  + ++ L++ Q  R   R++A 
Sbjct: 1140 EQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAG 1199

Query: 331  EDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAA 390
            E  + L E   +++ L     +L++ +   E E   +     A E K Q+L    E R A
Sbjct: 1200 ELRRSLGEGAKEREALRRSNEELRSAVKKAESE---RISLKLANEDKEQKLALLEEARTA 1256

Query: 391  AERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAK 450
              ++  +L   +Q++E        RLE                        R  + L+ +
Sbjct: 1257 VGKEAGELRTGLQEVER------SRLEAR----------------------RELQELRRQ 1288

Query: 451  QRALLKQLDSLDQEREELRGSL---DEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSL 507
             + L  +   L +E  EL+G L   + AE +  R    L+    +G+  L   ++ LQ  
Sbjct: 1289 MKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVA 1348

Query: 508  QREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQ 567
            QR+   L++   + R     L   LEE +  E+  +   D  R  E ++   R+ + E  
Sbjct: 1349 QRK---LQEQEGEFRTRERRLLGSLEEARGTEKQQL---DHARGLELKLEAARAEAAE-- 1400

Query: 568  ITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIPQDRLW 627
                         +  ++ A + R + L+ E  R++  + +    AQ GGL+        
Sbjct: 1401 -------------LGLRLSAAEGRAQGLEAELARVE--VQRRAAEAQLGGLR-------- 1437

Query: 628  SPSSKGTQGATPPVQAKSTSPGPLGRQHLPSSRTGRTLLGQPCTSPPRQPCTSPPRQPCT 687
            S   +G      P  A    PG   R   P+  +G  L      SP    C SP  QP  
Sbjct: 1438 SALRRGLGLGRAPSPAPRPVPGSPARD-APAEGSGEGL-----NSPSTLEC-SPGSQP-- 1488

Query: 688  SPPRQPCTSPS 698
             P   P TSP+
Sbjct: 1489 -PSPGPATSPA 1498



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 90/365 (24%), Positives = 160/365 (43%), Gaps = 63/365 (17%)

Query: 226  SVQGSLQKVGKVVISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTR 285
            ++ G L  + + +I+  +  +L   L   Q+LVQ     +    A++    A   +DL R
Sbjct: 943  TLTGELAGLRQQIIATQEKASLDKEL-MAQKLVQAEREAQ----ASLREQRAAHEEDLQR 997

Query: 286  LSKH-------VEALRAQLEEA------------EGQKDGLRKQAGKLEQALKQEQGARR 326
            L +        +EA RAQL+              E +K+ L ++   L+Q  ++++G   
Sbjct: 998  LQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQ--ERDEGLLL 1055

Query: 327  RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQ-----------AVE 375
             ++E+ +Q LS  E +K  L  +    +  +AT+  E+++Q+   Q           A+ 
Sbjct: 1056 AESEK-QQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALT 1114

Query: 376  AKAQQLQEEGERRAAAERQ-VQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEK 434
            ++ + L+ + E  AAA  Q V++L+EQ + L  Q    +   E    Q+         E 
Sbjct: 1115 SELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLL------ED 1168

Query: 435  ARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQR---ARVEEQL----- 486
            AR D + R     Q K R   +  +   QE  ELR SL E   +R    R  E+L     
Sbjct: 1169 AR-DGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVK 1227

Query: 487  --QSER-------EQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKE 537
              +SER       E  + +L   +E   ++ +E   L     ++  + LE  REL+EL+ 
Sbjct: 1228 KAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRR 1287

Query: 538  RERLL 542
            + ++L
Sbjct: 1288 QMKML 1292



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 63/296 (21%), Positives = 131/296 (44%), Gaps = 32/296 (10%)

Query: 336  LSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQE---EGE------ 386
            L E+  + +    E  +L+T+ + L R+L +      +  ++A+QLQ+   E E      
Sbjct: 1511 LREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSV 1570

Query: 387  --RRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQ 444
              R +  + ++   EE V++ E + +  + ++    + +    +EL   + ++  M  ++
Sbjct: 1571 DGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANE 1630

Query: 445  ESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSER---EQGQCQLRAQQ 501
              L+  +R L + LD+ +    +L       E QR  +E +LQ  R      + Q +A Q
Sbjct: 1631 TKLEGDKRRLKEVLDASESRTVKL-------ELQRRSLEGELQRSRLGLSDREAQAQALQ 1683

Query: 502  ELLQSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRS 561
            + + SLQR+    E     L+LT+  L   L +++E E  L            ++ G   
Sbjct: 1684 DRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGAL----------RDKVRGLTE 1733

Query: 562  SSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQGG 617
            +  +S  +    + +   H+++ + A +   +VLQE     +  LS+ R+ +   G
Sbjct: 1734 ALAQSSASL-NSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLG 1788



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 107/449 (23%), Positives = 184/449 (40%), Gaps = 56/449 (12%)

Query: 173 PSSPVLGLPQTCQEPESIPVRASLQFPATTFKNTRS-VHSQTIETALVPCDACASVQGSL 231
           PS P    P   + P   P       PA +  +T + +HS   +  L   D     + S 
Sbjct: 493 PSPPRRSSPGRGRSPRRGPS------PACSDSSTLALIHSALHKRQLQVQDMRGRYEASQ 546

Query: 232 QKVGKVVISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVE 291
             +G +   L  S++   +L +  Q ++D             R     R     LS+   
Sbjct: 547 DLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKS 606

Query: 292 ALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETS 351
            L   L+ A+ Q + LR++  KL+ A  QE+  R+R   E+EQ                 
Sbjct: 607 NLAHSLQVAQQQAEELRQEREKLQAA--QEELRRQRDRLEEEQ----------------E 648

Query: 352 DLKTKMATLERELKQQRESTQAVEAKAQQLQEE-GERRAAAERQVQQLEEQVQQLEAQVQ 410
           D     A + REL++     + +E K   L +E  E R A  R   Q  + +Q  +A+V 
Sbjct: 649 DAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQ-RDMLQAEKAEVA 707

Query: 411 LLVGRLEGAGQQVCWASTELDKEKARV-DSMVR---HQESLQAKQRALLKQLDSLDQERE 466
             + + E    ++  + T+L  E+A + DS+ +     ESL   +  L + +  L++E+ 
Sbjct: 708 EALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKS 767

Query: 467 ELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQEL--------LQSLQREKQGLEQAT 518
            L+G   +AE Q A V  + Q   E    +LR +QE+        L+  ++ ++ LEQ  
Sbjct: 768 ALQGRQRQAE-QEATVAREEQERLE----ELRLEQEVARQGLEGSLRVAEQAQEALEQQL 822

Query: 519 TDLRLTILELERELEELKE----RERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDS 574
             LR    +L+ +L +L      RE+ L       R  + Q+     ++ E +      +
Sbjct: 823 PTLRHERSQLQEQLAQLSRQLSGREQEL---EQARREAQRQVEALERAAREKEALAKEHA 879

Query: 575 GNVTDHMERQVQANDIRIRVLQEENGRLQ 603
           G     +  Q+ A +   R L EE  RL+
Sbjct: 880 G-----LAVQLVAAEREGRTLSEEATRLR 903



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 72/324 (22%), Positives = 135/324 (41%), Gaps = 28/324 (8%)

Query: 373 AVEAKAQQLQEEGERRAAAE-------RQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCW 425
           A+  +  Q+Q+   R  A++       +Q+   E + + LE Q+Q L  + +GA Q    
Sbjct: 527 ALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHED 586

Query: 426 ASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQ 485
           A  E+ + ++  + + R + +L    +   +Q + L QERE+L+ + +E   QR R+EE+
Sbjct: 587 AQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEE 646

Query: 486 LQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAF 545
            +   + G    R ++EL +S  R+ + LE   + L   ++E+   L     +  +L A 
Sbjct: 647 QEDAVQDG---ARVRRELERS-HRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAE 702

Query: 546 PDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDI----------RIRVL 595
                   T+   GR     S      +  ++ D + +    N+            +  L
Sbjct: 703 KAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQL 762

Query: 596 QEENGRLQSMLSKIREVAQQGGLKLIPQDRLWS---PSSKGTQGATPPVQAKSTSPGPLG 652
           +EE   LQ    + R+  Q+  +    Q+RL           QG    ++    +   L 
Sbjct: 763 EEEKSALQ---GRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEAL- 818

Query: 653 RQHLPSSRTGRTLLGQPCTSPPRQ 676
            Q LP+ R  R+ L +      RQ
Sbjct: 819 EQQLPTLRHERSQLQEQLAQLSRQ 842



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 88/391 (22%), Positives = 156/391 (39%), Gaps = 67/391 (17%)

Query: 272  VGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEE 331
            VG+ A E R  L  + +     R +L+E   Q   L  +  +L + L + QG        
Sbjct: 1257 VGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGR------- 1309

Query: 332  DEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAA 391
                L+  E  +++   ET  L+ ++   E  L+  R+  Q  + K Q  ++EGE R   
Sbjct: 1310 ----LALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQ--EQEGEFRTRE 1363

Query: 392  ERQVQQLEE----QVQQLE----AQVQLLVGRLEGAGQQVCWASTE-----LDKEKARVD 438
             R +  LEE    + QQL+     +++L   R E A   +  ++ E     L+ E ARV+
Sbjct: 1364 RRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVE 1423

Query: 439  SMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVE---EQLQS------- 488
               R  E+     R+ L++   L +        +  + A+ A  E   E L S       
Sbjct: 1424 VQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECS 1483

Query: 489  -------------------EREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELE 529
                               + E  +  LR   + L+S QRE+  L   T+ L   + E+E
Sbjct: 1484 PGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEME 1543

Query: 530  RELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDH--------- 580
             E +    R R L             +  GR S V++++    +S   ++          
Sbjct: 1544 AERDSATSRARQLQKAVAESEEARRSV-DGRLSGVQAELALQEESVRRSERERRATLDQV 1602

Query: 581  --MERQVQANDIRIRVLQEENGRLQSMLSKI 609
              +ER +QA +  +R  QE+  ++++  +K+
Sbjct: 1603 ATLERSLQATESELRASQEKISKMKANETKL 1633



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 114/491 (23%), Positives = 193/491 (39%), Gaps = 69/491 (14%)

Query: 291 EALRAQLEEAEGQKD-GLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTE 349
           +ALR +  E E Q+  GL +Q+ +L + L++EQ + RR+ +  ++         Q+L  +
Sbjct: 120 QALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGK 179

Query: 350 TSDLKTKMATLER-------ELKQQR----ESTQAVEAKAQQLQEEGERRAAAERQVQQL 398
               K + + LE+       EL+QQR    E +Q +E+   +L+EE +R A+  +    L
Sbjct: 180 ILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAML 239

Query: 399 EEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQL 458
            EQ+ Q  +  Q L   +            EL+  +A   +  R +ES  A       +L
Sbjct: 240 REQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREA---AWRREEESFNAYFSNEHSRL 296

Query: 459 DSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQE----LLQSLQREKQGL 514
             L ++    R  + E +    R   QL  E  +     RA QE    L   L+  +   
Sbjct: 297 LLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTS---RAVQEAGLGLSTGLRLAESRA 353

Query: 515 EQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDS 574
           E A     L   +LE +L +   RE+ L       +  ++ +     + + +++   T+ 
Sbjct: 354 EAALEKQALLQAQLEEQLRDKVLREKDLA-----QQQMQSDLD---KADLSARV---TEL 402

Query: 575 GNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIPQDRLWSPSSKGT 634
           G     +E+Q    D   + L E+   L+S             L+L  Q  L +   +G 
Sbjct: 403 GLAVKRLEKQNLEKDQVNKDLTEKLEALES-------------LRLQEQAALETEDGEGL 449

Query: 635 QGATPPVQAKSTSPGPLGRQHLPSSRTG-------RTLLGQPCTSPPRQPCTSPPRQPCT 687
           Q     +     S    G Q   S RT        R L GQ   SPPR+  +SP R    
Sbjct: 450 QQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRR--SSPGR---- 503

Query: 688 SPPRQPCTSPSRQPCSQPSKSLLEGVTHLDTCTQNPIK--------VLVRLRKRLSPGRG 739
              R P   PS       + +L+    H        ++        +L  LRK+LS    
Sbjct: 504 --GRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSES 561

Query: 740 QASSAHQPQER 750
           +  +  +  +R
Sbjct: 562 ERRALEEQLQR 572



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 87/372 (23%), Positives = 141/372 (37%), Gaps = 59/372 (15%)

Query: 278 EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLS 337
           +QR   T  S+ +E+   +LEE + +   L +    L + L Q   A +  +E+  +  +
Sbjct: 203 QQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTN 262

Query: 338 EWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQ 397
           +W   +++L               RE   +RE     E+       E  R     RQV  
Sbjct: 263 DWTRCRKEL-------------EHREAAWRREE----ESFNAYFSNEHSRLLLLWRQVVG 305

Query: 398 LEEQVQQL----EAQVQLLVGRLEGAGQQVCWA----STELDKEKARVDSMVRHQESLQA 449
               V ++    E  +  L G L    + V  A    ST L   ++R ++ +  Q  LQA
Sbjct: 306 FRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQA 365

Query: 450 KQRALL--KQLDSLDQEREELRGSLDEAEAQRARVE--------EQLQSEREQGQCQLRA 499
           +    L  K L   D  +++++  LD+A+      E        E+   E++Q    L  
Sbjct: 366 QLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTE 425

Query: 500 QQELLQSLQREKQ---------GLEQATTDLRLTILELERELEELKERERLLVAFPDLHR 550
           + E L+SL+ ++Q         GL+Q   DL   +L       +L   ER   A     R
Sbjct: 426 KLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLR 485

Query: 551 ----------PTETQIHGGRSSSVESQITCPTDSGNVTDHM---ERQVQANDIRIR--VL 595
                     P  +    GRS        C   S     H    +RQ+Q  D+R R    
Sbjct: 486 GLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEAS 545

Query: 596 QEENGRLQSMLS 607
           Q+  G L+  LS
Sbjct: 546 QDLLGTLRKQLS 557


>gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]
          Length = 841

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 109/454 (24%), Positives = 184/454 (40%), Gaps = 72/454 (15%)

Query: 274 RWAAEQRKDLTR---LSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAE 330
           R  A+ +  L R   L + +EA    L E   Q+ G R +     +AL+ +   +   A+
Sbjct: 266 RKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQ 325

Query: 331 EDEQCLSEWEHDKQQLLTETSDLKTKMATLER-------ELKQQRESTQAVEAKAQQLQE 383
           E  +           LL E + L+T +A LE+       EL   RE T  + A+ QQ Q 
Sbjct: 326 EQVE----------GLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQA 375

Query: 384 EGERRAAAERQVQ-QLEEQVQ---QLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDS 439
           E E     +  +  QL+E ++   +L  Q+Q +    E   Q++  A    +K KA +D 
Sbjct: 376 EYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDE 435

Query: 440 MV--------RHQESLQAK---------------QRALLKQLDSLDQEREELRGSLDEAE 476
           +         +H+E L A                +R L +  +   ++ EELRG + E +
Sbjct: 436 LAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEK 495

Query: 477 AQRARVEEQLQSEREQGQCQLR---------------AQQELLQSLQREKQGLEQATTDL 521
           A R R  E LQ   E+ Q Q+                A++ L Q  Q +++ L+Q     
Sbjct: 496 A-RTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQH 554

Query: 522 RLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHM 581
              +   E EL++++++        D H  T + +      +V+ Q             +
Sbjct: 555 AAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDL 614

Query: 582 ERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIPQDRLWSPSSKGTQGATPPV 641
           +RQ+     R   LQE   RLQ +L+  +    + GL+ +    + SPS   T  ++   
Sbjct: 615 KRQLHLERKRADKLQE---RLQDILTNSK---SRSGLEELVLSEMNSPSRTQTGDSS--- 665

Query: 642 QAKSTSPGPLGRQHLPSSRTGRTLLGQPCTSPPR 675
              S S   + R+   S+   R+L   P   PPR
Sbjct: 666 SISSFSYREILREKESSAVPARSLSSSPQAQPPR 699



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 67/328 (20%), Positives = 147/328 (44%), Gaps = 42/328 (12%)

Query: 307 LRKQAGKLEQALKQEQGA--RRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLEREL 364
           LR++   L++   + Q A  + ++A+E E  LSE E  + +L ++  D + + +TL  E 
Sbjct: 41  LRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEF 100

Query: 365 KQQRESTQAVEAKAQQLQEEGERRAAAER------QVQQLEEQVQQLEAQVQLLVGRL-E 417
            +     + +E + QQL+E       A+       ++ +L+ +   L+  V  L  R  +
Sbjct: 101 SKLCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGK 160

Query: 418 GAGQQVCWASTELDKEKARVDSMVRHQ---------ESLQAKQRALLKQLDSLDQEREEL 468
            AG+    +  + D       +++            E  + ++R L +QL  L+  ++  
Sbjct: 161 EAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAE 220

Query: 469 RGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREK-QGLEQ-ATTDLRLTIL 526
              L E   + A++ E+L+ ++++  C+L+ ++E L +  R K + L+Q    D +  + 
Sbjct: 221 TSRLQE---ELAKLSEKLK-KKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 276

Query: 527 ELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQ 586
             ++  +EL+   + L    D  R  E   H     +++ Q++               +Q
Sbjct: 277 RTQKLQQELEAANQSLAELRD-QRQGERLEHAAALRALQDQVS---------------IQ 320

Query: 587 ANDIRIRV--LQEENGRLQSMLSKIREV 612
           + D + +V  L  EN  L++ L+ + ++
Sbjct: 321 SADAQEQVEGLLAENNALRTSLAALEQI 348



 Score = 35.0 bits (79), Expect = 0.26
 Identities = 51/224 (22%), Positives = 95/224 (42%), Gaps = 35/224 (15%)

Query: 334 QCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAER 393
           Q LSE E  + Q   +  +L+T    L  EL++      ++  K   L +E  +   A  
Sbjct: 3   QALSEEEFQRMQ--AQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60

Query: 394 QVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRA 453
           + ++ +E V+ L ++ ++L  +L               +E  R+ +      +L A+   
Sbjct: 61  KSKKAQE-VEVLLSENEMLQAKLHS------------QEEDFRLQN-----STLMAEFSK 102

Query: 454 LLKQLDSLDQEREELR-GSLDEAEAQRARVEE----QLQSEREQGQCQLRAQQE------ 502
           L  Q++ L+QE ++L+ G+     AQ   + +    +LQ+E    Q  + A QE      
Sbjct: 103 LCSQMEQLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEA 162

Query: 503 ----LLQSLQREKQGLEQATTDLRLTILELERELEELKERERLL 542
                +   Q +  G    T    + + E+E + E  KE +RLL
Sbjct: 163 GKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLL 206


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 95/413 (23%), Positives = 180/413 (43%), Gaps = 44/413 (10%)

Query: 225  ASVQGSLQKVGKVVISLCQSQN--LPSSLGQFQQLVQDSMGLRP-LPAATVGRWAAEQRK 281
            A ++  L ++ K   S  + Q   +  +L Q +Q+ ++ + L+     A  G+  AE   
Sbjct: 1889 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELEL 1946

Query: 282  DLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQ----CLS 337
            +L R+  + E      E+AE        +A +  Q L  E+  RRR+AEE  Q       
Sbjct: 1947 ELGRIRSNAEDTLRSKEQAE-------LEAARQRQ-LAAEEERRRREAEERVQKSLAAEE 1998

Query: 338  EWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQL-QEEGERRAAAERQ-- 394
            E    ++  L E   LK K+     E ++ RE  +   A+  QL QE  ++R  AE +  
Sbjct: 1999 EAARQRKAALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2054

Query: 395  ---VQQLEEQVQQLEAQVQLLVGRLEG-------AGQQVCWASTELDKEKARVDSMVRHQ 444
               VQQ E+++QQ   Q Q ++ +L G       A ++   A  + ++E A+    V   
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114

Query: 445  ESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELL 504
            E L+       +         E+LR   ++  A+RA+ E+    +++    ++   ++  
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174

Query: 505  QSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSV 564
            +   R+K  +EQ  T LRL + E + +   L E  + L A        E      + S V
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA--------EATEAARQRSQV 2226

Query: 565  ESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGR--LQSMLSKIREVAQQ 615
            E ++            ++ +++A +  + +  ++N +  LQ    K+++VA++
Sbjct: 2227 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 94/412 (22%), Positives = 178/412 (43%), Gaps = 47/412 (11%)

Query: 243  QSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEG 302
            Q +++   L Q +Q  +  +  +   A    R      +++  +   +EA   Q   AEG
Sbjct: 1414 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473

Query: 303  QKDGLRKQAGKLEQALKQ--EQGARRRQAEEDE---------------QCLSEWEHDKQQ 345
            +   LR +A + E   +Q  E+  R R+  +DE               +  +E   +KQ+
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533

Query: 346  LLTETSDLKTKMATLERELKQ-QRESTQAVEAKAQQLQEEGE-----RRAAAERQVQQLE 399
             L    +L+ +    ER L+Q + E  + V+   +  Q   E     +RA+   +  QLE
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593

Query: 400  EQVQQLEAQVQLLVGRLEGAGQQVC-------WASTELDKEKARVDSMVRHQESLQAKQR 452
              +Q+    V  L    E   QQ          A  EL++ + + +  +R +  LQA++ 
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR--LQAEEV 1651

Query: 453  ALLKQLDSLDQEREELRGSLDEAEAQ---RARVEEQLQSEREQGQCQLRAQQELLQSLQR 509
            A  K L   + E+++     +EAE +   R + EEQ   +RE  + +L  Q++L +   +
Sbjct: 1652 AQQKSLAQAEAEKQK-----EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706

Query: 510  EKQGLEQATTDLRLTIL--ELEREL--EELKERERLLVAFPDLHRPTETQIHGGRSSS-- 563
            ++   EQ    LR      E +R+L  EEL   +R   A     +  E ++   R+    
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1766

Query: 564  -VESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQ 614
             + S+     +S + ++  +++++A   R R L EE  RL+++  + +   Q
Sbjct: 1767 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1818



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 77/313 (24%), Positives = 144/313 (46%), Gaps = 49/313 (15%)

Query: 327  RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATL-ERELKQQRESTQAVEAKAQQLQEEG 385
            R+ EE+E+   +   ++++ L E      K   L E   + + ++ +  +   Q++QEE 
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401

Query: 386  ERRAAA----ERQVQQLEEQVQQL----EAQVQLLVGRLEGAGQQVCWASTELDKEKARV 437
             RR  A    ++Q + ++E++QQL    EA++Q    + E A           ++ + R+
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA-----------ERSRLRI 1450

Query: 438  DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQ----G 493
            +  +R    ++ +  A  +Q    + E + LR   +EAEAQ+ + +E+ +  R Q     
Sbjct: 1451 EEEIR---VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507

Query: 494  QCQLRAQQELLQSLQ------REKQGLEQATTDLRLTILELERELE--ELKERERLLVAF 545
            Q + +A+ EL   ++      REKQ   QA  +LRL   E ER L   E++   ++ VA 
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1567

Query: 546  PDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEE---NGRL 602
                R  E ++   R+S  E            T  +ER +Q   + +  L+EE     + 
Sbjct: 1568 ETAQRSAEAELQSKRASFAEK-----------TAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 603  QSMLSKIREVAQQ 615
            Q+   + RE A++
Sbjct: 1617 QAEAERAREEAER 1629



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 74/272 (27%), Positives = 127/272 (46%), Gaps = 13/272 (4%)

Query: 277  AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
            AE+R+ L  +   +E  R QL EA  Q     ++  K  Q   QE+  RR +A  D Q  
Sbjct: 1356 AEERERLAEVEAALEKQR-QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1414

Query: 337  SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEG--ERRAAAERQ 394
                 ++ Q L ++S+ + +    + E  ++       E +  +LQ E    +R  AE +
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474

Query: 395  VQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQ-ESLQAKQRA 453
            +Q L  + ++ EAQ +      E   +QV   S    + +  + S V+ + E+ + KQRA
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534

Query: 454  LLKQLDSLDQEREELRGSLDEAEAQRAR-VEEQLQSEREQGQCQLRAQQ----ELLQSLQ 508
            L + L+ L  + EE    L +AE +RAR V+  L++ +   + +L++++    E    L+
Sbjct: 1535 L-QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593

Query: 509  REKQGLEQATTDLRLTILELERELEELKERER 540
            R  Q    A   LR    E ER  ++  E ER
Sbjct: 1594 RSLQEEHVAVAQLR---EEAERRAQQQAEAER 1622



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 73/287 (25%), Positives = 136/287 (47%), Gaps = 24/287 (8%)

Query: 276  AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKL-------EQALKQEQGARRRQ 328
            A E  +  +++ + + ++R Q+EE    K  +  +   L        Q   QE+  + +Q
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2275

Query: 329  AEEDEQCLSEWEHDKQQL--LTETSDLKTKMATLERELKQQRESTQA---VEAKAQQLQE 383
              E+   LS    +  +L  L E  DL  + A  E+ LK++ ++ Q    ++A+A+ LQ+
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAE-EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334

Query: 384  EGERRAAAERQVQQLEEQV-QQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVR 442
            + E      R++Q+ +EQ+ QQL  + Q     LE   Q+    S E ++ K RV  M R
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394

Query: 443  HQESLQAKQRALLKQLDSLDQE--REELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQ 500
             Q   +   +   KQ + + ++  R EL      A  ++  + + L+ +R+Q        
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTEL------ATQEKVTLVQTLEIQRQQSDHDAERL 2448

Query: 501  QELLQSLQREKQGLEQATTDLRLTILELERELEE--LKERERLLVAF 545
            +E +  L+REK+ L+Q    L+L   E++   +E  L+E + L  +F
Sbjct: 2449 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2495



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 74/270 (27%), Positives = 124/270 (45%), Gaps = 23/270 (8%)

Query: 292  ALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGA---RRRQAEEDEQCLSEWEHDKQQLLT 348
            A R+   E + ++    ++  +LE++L++E  A    R +AE   Q  +E E  +++   
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629

Query: 349  ETS--DLKTKMATLER----ELKQQRESTQA-VEAKAQQLQEEGERRAAAERQ-VQQLEE 400
            E     LK   A   R    E+ QQ+   QA  E + ++ + E  RR  AE Q V+Q E 
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1689

Query: 401  QVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDS 460
              Q+LE Q QL     EG  QQ   A  EL + +A  +   + ++ L+ +   L ++  +
Sbjct: 1690 AEQELEKQRQLA----EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745

Query: 461  LDQEREELRGSLDEAEAQ-------RARVEEQLQSEREQGQCQLRAQQELLQSLQREKQG 513
              Q+R+EL   L +  A+       +AR EE+ +S  E+ + +L A+    + L  E   
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805

Query: 514  LEQATTDL-RLTILELERELEELKERERLL 542
            L     +  R   L  E    +  E ER+L
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQRAEAERVL 1835



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 69/332 (20%), Positives = 152/332 (45%), Gaps = 26/332 (7%)

Query: 227  VQGSLQKVGKVVISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRL 286
            +Q   +K+ +V     +         + +QL ++ +  +   A  + +   +  ++ TRL
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325

Query: 287  SKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQL 346
                E L+ Q E A+ Q   L++   ++ Q L +E    +R  E + Q        + ++
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ-------RQLEM 2378

Query: 347  LTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQ----VQQLEEQV 402
              E   LK ++A + R   +  E  Q    +A+++ E+  R   A ++    VQ LE Q 
Sbjct: 2379 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2438

Query: 403  QQLEAQVQLL---VGRLEGAGQQVCWASTELDKEKARVDSMVRHQ--ESLQAKQRALLKQ 457
            QQ +   + L   +  LE   +++   +  L  +   + ++ + Q  +  QA Q++ L +
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498

Query: 458  LDSL-------DQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQRE 510
             DSL       +QE+ +L     +  A+  ++ E+ Q +++Q +   + +Q L+ S++  
Sbjct: 2499 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEA 2555

Query: 511  KQGLEQATTDLRLTILELERELEELKERERLL 542
            ++   +A   +R    EL++  ++ +++E LL
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 105/401 (26%), Positives = 180/401 (44%), Gaps = 48/401 (11%)

Query: 270  ATVGRWAAEQRKDLTRLS-KHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRR- 327
            A   R   E  ++L R   K  EALR +L+  E  +     QA   +Q  + E+ ARRR 
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1677

Query: 328  QAEED---EQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEE 384
            +AEE    ++ L+E E +KQ+ L E +  +   A  E+EL + R  T+  E + Q L+EE
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA--EQELIRLRAETEQGEQQRQLLEEE 1735

Query: 385  GER----RAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTE----LDKEKAR 436
              R     AAA ++ Q+LE ++ ++ A++++L+     A ++    S +    L+ E  R
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1795

Query: 437  VDSMVRHQESL-----QAKQRALLKQLDSLDQEREELRGSLDE----AEAQRARVEEQL- 486
               +      L     +AK++  L + D+  Q  E  R   ++     EA R + E ++ 
Sbjct: 1796 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855

Query: 487  --QSEREQGQCQLRAQQELLQSLQREKQGLE-QATTDLRLTIL------ELEREL----E 533
              + E E  + +  A+ E  Q  + E+Q  + +A  + RL  L      ELER+     +
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915

Query: 534  ELKER----ERLLVAFPDLHR----PTETQIHGGRSSSVESQITCPTDSGNVTDHMERQV 585
             L++R    E +L       +      E ++  GR  S         +   +    +RQ+
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975

Query: 586  QANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIPQDRL 626
             A + R R  +E   R+Q  L+   E A+Q    L   +RL
Sbjct: 1976 AAEEERRR--REAEERVQKSLAAEEEAARQRKAALEEVERL 2014



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 58/202 (28%), Positives = 99/202 (49%), Gaps = 17/202 (8%)

Query: 291  EALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTET 350
            E LR  + E E +K+ L+++A  L+  LK E+     Q  + EQ L E +  +Q  L+E 
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQ--LKSEE----MQTVQQEQLLQETQALQQSFLSEK 2499

Query: 351  SDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQ 410
              L  +   +E+E  +  +  Q   AKAQQL+EE       +RQ QQ+E++ Q+L A ++
Sbjct: 2500 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE------QQRQQQQMEQERQRLVASME 2553

Query: 411  LLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ-RALLKQLDSLDQEREELR 469
                R   A + V     EL     +++   R QE L A++ + L +QL  L+++     
Sbjct: 2554 EARRRQHEAEEGVRRKQEELQ----QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2609

Query: 470  GSLDEAEAQRARVEEQLQSERE 491
               +E  A +    + L + R+
Sbjct: 2610 AHSEEVTASQVAATKTLPNGRD 2631



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 64/364 (17%), Positives = 163/364 (44%), Gaps = 36/364 (9%)

Query: 269  AATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGAR--R 326
            A  +G W  + R    R  + ++A+   L +++  ++ LR++   LE+  +  +     +
Sbjct: 1216 ADPLGAWLQDAR----RRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1269

Query: 327  RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGE 386
            R A++    + ++E    QL+T  + L+  +A+  ++ K Q  S   ++          E
Sbjct: 1270 RFAKQYINAIKDYE---LQLVTYKAQLEP-VASPAKKPKVQSGSESVIQEYVDLRTHYSE 1325

Query: 387  RRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQES 446
                  + ++ + E ++++E + +L   +     +++      L+K++   ++  + +  
Sbjct: 1326 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ 1385

Query: 447  LQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQS 506
             + + + L +++      REE   +  +A+ Q+  ++E+LQ  R+  + +++A+    ++
Sbjct: 1386 AEREAKELQQRMQEEVVRREE---AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442

Query: 507  LQREKQGLEQATTDLRLTILELER-------ELEELKERERLLVA--------FPDLHRP 551
             +R +  +E+    +RL +   ER       EL+ L+ R     A           L R 
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502

Query: 552  TETQIHGGRSSSVE--SQITCPTDSGNVTDHMERQVQA-NDIRIRVLQEENGRLQSMLSK 608
             + +    R + VE  S++    ++       +R +QA  ++R++  + E    Q+ + +
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAR---EKQRALQALEELRLQAEEAERRLRQAEVER 1559

Query: 609  IREV 612
             R+V
Sbjct: 1560 ARQV 1563



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 72/308 (23%), Positives = 126/308 (40%), Gaps = 56/308 (18%)

Query: 282  DLTRLSKHVEALRAQLEEAEGQKDGLRKQ---AGKLEQALKQEQGAR----RRQAEEDEQ 334
            +L      ++ LRAQ E  +   D LR +   A ++ + L+Q  G R     R  E   Q
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1183

Query: 335  CLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGER-RAAAER 393
             L  W    Q +L +T   + ++  L R+L+  RES   + A  Q  +   E+ +A    
Sbjct: 1184 LLERW----QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1239

Query: 394  QVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQ----- 448
              Q + EQ++Q +A ++ +    E   +   +A   ++  K     +V ++  L+     
Sbjct: 1240 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1299

Query: 449  AKQRALLKQLDSLDQEREELRGSLDE-------------------------AEAQRARVE 483
            AK+  +    +S+ QE  +LR    E                         AE QRA   
Sbjct: 1300 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359

Query: 484  EQL---------QSEREQGQCQLRAQ-----QELLQSLQREKQGLEQATTDLRLTILELE 529
            E+L         Q +  +   Q +AQ     +EL Q +Q E    E+A  D +     ++
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419

Query: 530  RELEELKE 537
             EL++L++
Sbjct: 1420 EELQQLRQ 1427



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 75/305 (24%), Positives = 137/305 (44%), Gaps = 32/305 (10%)

Query: 250  SLGQFQQLVQDSMGLRPLPAATVGRWAAE-QRKDLTRLSKHVEALRAQLEEAEG--QKDG 306
            SL  +Q L +D   +R    AT      E QR+ L  L  H +A     ++A G   +D 
Sbjct: 892  SLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR 951

Query: 307  L--RKQAGKLEQALKQEQGARRRQAEED---EQCLSEWEHDKQQL-LTETSDLKTKMATL 360
            L   ++ G      +Q   +  + A+E+   ++C+SE +  + QL   ET  +      L
Sbjct: 952  LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 1011

Query: 361  E----RELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQ---VQQLEAQVQLLV 413
            +    RE  Q+    Q  +A+ + L +   R +A   +V  L E       L ++++L +
Sbjct: 1012 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1071

Query: 414  GRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLD 473
            G+LE   Q    ++  L+K K  +  ++R  +  +   RA  +QL    +E + +  +L 
Sbjct: 1072 GKLE---QVRSLSAIYLEKLKT-ISLVIRGTQGAEEVLRAHEEQL----KEAQAVPATLP 1123

Query: 474  EAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELE 533
            E EA +A +++         + Q  AQQ    +L+ E +G ++    L+    E + E+E
Sbjct: 1124 ELEATKASLKKL--------RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1175

Query: 534  ELKER 538
              +ER
Sbjct: 1176 RWRER 1180



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 44/141 (31%), Positives = 65/141 (46%), Gaps = 13/141 (9%)

Query: 396 QQLEEQVQQLEAQVQLLVGRLE----GAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ 451
           Q+ +E V +LEAQ Q LV             + W S   D +  R  S+   +     +Q
Sbjct: 863 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 922

Query: 452 RALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQ--- 508
           R  L  L+   Q    LR S D   A     E++L +ERE G C    QQ LLQSL+   
Sbjct: 923 RQALHSLELHYQAF--LRDSQD---AGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGA 976

Query: 509 REKQGLEQATTDLRLTILELE 529
           +E+   ++  ++L+   L+LE
Sbjct: 977 QEESRCQRCISELKDIRLQLE 997



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 30/158 (18%), Positives = 67/158 (42%), Gaps = 5/158 (3%)

Query: 253  QFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAG 312
            + +QL QD +           R   +  ++  RL   +E  R +  EAE      +++  
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574

Query: 313  KLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQ 372
            +LEQ  +Q++     + +   + L   E   +  L  + ++        + L   R++  
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2634

Query: 373  AVEAKAQ-QLQEEGERRAAAERQVQQL----EEQVQQL 405
               A+A+ +   +G RR  + +++Q+      E++Q+L
Sbjct: 2635 GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2672


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 95/413 (23%), Positives = 180/413 (43%), Gaps = 44/413 (10%)

Query: 225  ASVQGSLQKVGKVVISLCQSQN--LPSSLGQFQQLVQDSMGLRP-LPAATVGRWAAEQRK 281
            A ++  L ++ K   S  + Q   +  +L Q +Q+ ++ + L+     A  G+  AE   
Sbjct: 1893 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELEL 1950

Query: 282  DLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQ----CLS 337
            +L R+  + E      E+AE        +A +  Q L  E+  RRR+AEE  Q       
Sbjct: 1951 ELGRIRSNAEDTLRSKEQAE-------LEAARQRQ-LAAEEERRRREAEERVQKSLAAEE 2002

Query: 338  EWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQL-QEEGERRAAAERQ-- 394
            E    ++  L E   LK K+     E ++ RE  +   A+  QL QE  ++R  AE +  
Sbjct: 2003 EAARQRKAALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2058

Query: 395  ---VQQLEEQVQQLEAQVQLLVGRLEG-------AGQQVCWASTELDKEKARVDSMVRHQ 444
               VQQ E+++QQ   Q Q ++ +L G       A ++   A  + ++E A+    V   
Sbjct: 2059 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2118

Query: 445  ESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELL 504
            E L+       +         E+LR   ++  A+RA+ E+    +++    ++   ++  
Sbjct: 2119 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2178

Query: 505  QSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSV 564
            +   R+K  +EQ  T LRL + E + +   L E  + L A        E      + S V
Sbjct: 2179 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA--------EATEAARQRSQV 2230

Query: 565  ESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGR--LQSMLSKIREVAQQ 615
            E ++            ++ +++A +  + +  ++N +  LQ    K+++VA++
Sbjct: 2231 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2283



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 94/412 (22%), Positives = 178/412 (43%), Gaps = 47/412 (11%)

Query: 243  QSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEG 302
            Q +++   L Q +Q  +  +  +   A    R      +++  +   +EA   Q   AEG
Sbjct: 1418 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1477

Query: 303  QKDGLRKQAGKLEQALKQ--EQGARRRQAEEDE---------------QCLSEWEHDKQQ 345
            +   LR +A + E   +Q  E+  R R+  +DE               +  +E   +KQ+
Sbjct: 1478 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1537

Query: 346  LLTETSDLKTKMATLERELKQ-QRESTQAVEAKAQQLQEEGE-----RRAAAERQVQQLE 399
             L    +L+ +    ER L+Q + E  + V+   +  Q   E     +RA+   +  QLE
Sbjct: 1538 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1597

Query: 400  EQVQQLEAQVQLLVGRLEGAGQQVC-------WASTELDKEKARVDSMVRHQESLQAKQR 452
              +Q+    V  L    E   QQ          A  EL++ + + +  +R +  LQA++ 
Sbjct: 1598 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR--LQAEEV 1655

Query: 453  ALLKQLDSLDQEREELRGSLDEAEAQ---RARVEEQLQSEREQGQCQLRAQQELLQSLQR 509
            A  K L   + E+++     +EAE +   R + EEQ   +RE  + +L  Q++L +   +
Sbjct: 1656 AQQKSLAQAEAEKQK-----EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1710

Query: 510  EKQGLEQATTDLRLTIL--ELEREL--EELKERERLLVAFPDLHRPTETQIHGGRSSS-- 563
            ++   EQ    LR      E +R+L  EEL   +R   A     +  E ++   R+    
Sbjct: 1711 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1770

Query: 564  -VESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQ 614
             + S+     +S + ++  +++++A   R R L EE  RL+++  + +   Q
Sbjct: 1771 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1822



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 77/313 (24%), Positives = 144/313 (46%), Gaps = 49/313 (15%)

Query: 327  RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATL-ERELKQQRESTQAVEAKAQQLQEEG 385
            R+ EE+E+   +   ++++ L E      K   L E   + + ++ +  +   Q++QEE 
Sbjct: 1346 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1405

Query: 386  ERRAAA----ERQVQQLEEQVQQL----EAQVQLLVGRLEGAGQQVCWASTELDKEKARV 437
             RR  A    ++Q + ++E++QQL    EA++Q    + E A           ++ + R+
Sbjct: 1406 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA-----------ERSRLRI 1454

Query: 438  DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQ----G 493
            +  +R    ++ +  A  +Q    + E + LR   +EAEAQ+ + +E+ +  R Q     
Sbjct: 1455 EEEIR---VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1511

Query: 494  QCQLRAQQELLQSLQ------REKQGLEQATTDLRLTILELERELE--ELKERERLLVAF 545
            Q + +A+ EL   ++      REKQ   QA  +LRL   E ER L   E++   ++ VA 
Sbjct: 1512 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1571

Query: 546  PDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEE---NGRL 602
                R  E ++   R+S  E            T  +ER +Q   + +  L+EE     + 
Sbjct: 1572 ETAQRSAEAELQSKRASFAEK-----------TAQLERSLQEEHVAVAQLREEAERRAQQ 1620

Query: 603  QSMLSKIREVAQQ 615
            Q+   + RE A++
Sbjct: 1621 QAEAERAREEAER 1633



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 74/272 (27%), Positives = 127/272 (46%), Gaps = 13/272 (4%)

Query: 277  AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
            AE+R+ L  +   +E  R QL EA  Q     ++  K  Q   QE+  RR +A  D Q  
Sbjct: 1360 AEERERLAEVEAALEKQR-QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1418

Query: 337  SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEG--ERRAAAERQ 394
                 ++ Q L ++S+ + +    + E  ++       E +  +LQ E    +R  AE +
Sbjct: 1419 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1478

Query: 395  VQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQ-ESLQAKQRA 453
            +Q L  + ++ EAQ +      E   +QV   S    + +  + S V+ + E+ + KQRA
Sbjct: 1479 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1538

Query: 454  LLKQLDSLDQEREELRGSLDEAEAQRAR-VEEQLQSEREQGQCQLRAQQ----ELLQSLQ 508
            L + L+ L  + EE    L +AE +RAR V+  L++ +   + +L++++    E    L+
Sbjct: 1539 L-QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1597

Query: 509  REKQGLEQATTDLRLTILELERELEELKERER 540
            R  Q    A   LR    E ER  ++  E ER
Sbjct: 1598 RSLQEEHVAVAQLR---EEAERRAQQQAEAER 1626



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 73/287 (25%), Positives = 136/287 (47%), Gaps = 24/287 (8%)

Query: 276  AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKL-------EQALKQEQGARRRQ 328
            A E  +  +++ + + ++R Q+EE    K  +  +   L        Q   QE+  + +Q
Sbjct: 2220 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2279

Query: 329  AEEDEQCLSEWEHDKQQL--LTETSDLKTKMATLERELKQQRESTQA---VEAKAQQLQE 383
              E+   LS    +  +L  L E  DL  + A  E+ LK++ ++ Q    ++A+A+ LQ+
Sbjct: 2280 VAEEAARLSVAAQEAARLRQLAE-EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2338

Query: 384  EGERRAAAERQVQQLEEQV-QQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVR 442
            + E      R++Q+ +EQ+ QQL  + Q     LE   Q+    S E ++ K RV  M R
Sbjct: 2339 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2398

Query: 443  HQESLQAKQRALLKQLDSLDQE--REELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQ 500
             Q   +   +   KQ + + ++  R EL      A  ++  + + L+ +R+Q        
Sbjct: 2399 AQARAEEDAQRFRKQAEEIGEKLHRTEL------ATQEKVTLVQTLEIQRQQSDHDAERL 2452

Query: 501  QELLQSLQREKQGLEQATTDLRLTILELERELEE--LKERERLLVAF 545
            +E +  L+REK+ L+Q    L+L   E++   +E  L+E + L  +F
Sbjct: 2453 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2499



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 74/270 (27%), Positives = 124/270 (45%), Gaps = 23/270 (8%)

Query: 292  ALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGA---RRRQAEEDEQCLSEWEHDKQQLLT 348
            A R+   E + ++    ++  +LE++L++E  A    R +AE   Q  +E E  +++   
Sbjct: 1574 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1633

Query: 349  ETS--DLKTKMATLER----ELKQQRESTQA-VEAKAQQLQEEGERRAAAERQ-VQQLEE 400
            E     LK   A   R    E+ QQ+   QA  E + ++ + E  RR  AE Q V+Q E 
Sbjct: 1634 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1693

Query: 401  QVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDS 460
              Q+LE Q QL     EG  QQ   A  EL + +A  +   + ++ L+ +   L ++  +
Sbjct: 1694 AEQELEKQRQLA----EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1749

Query: 461  LDQEREELRGSLDEAEAQ-------RARVEEQLQSEREQGQCQLRAQQELLQSLQREKQG 513
              Q+R+EL   L +  A+       +AR EE+ +S  E+ + +L A+    + L  E   
Sbjct: 1750 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1809

Query: 514  LEQATTDL-RLTILELERELEELKERERLL 542
            L     +  R   L  E    +  E ER+L
Sbjct: 1810 LRALAEEAKRQRQLAEEDAARQRAEAERVL 1839



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 69/332 (20%), Positives = 152/332 (45%), Gaps = 26/332 (7%)

Query: 227  VQGSLQKVGKVVISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRL 286
            +Q   +K+ +V     +         + +QL ++ +  +   A  + +   +  ++ TRL
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329

Query: 287  SKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQL 346
                E L+ Q E A+ Q   L++   ++ Q L +E    +R  E + Q        + ++
Sbjct: 2330 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ-------RQLEM 2382

Query: 347  LTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQ----VQQLEEQV 402
              E   LK ++A + R   +  E  Q    +A+++ E+  R   A ++    VQ LE Q 
Sbjct: 2383 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2442

Query: 403  QQLEAQVQLL---VGRLEGAGQQVCWASTELDKEKARVDSMVRHQ--ESLQAKQRALLKQ 457
            QQ +   + L   +  LE   +++   +  L  +   + ++ + Q  +  QA Q++ L +
Sbjct: 2443 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2502

Query: 458  LDSL-------DQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQRE 510
             DSL       +QE+ +L     +  A+  ++ E+ Q +++Q +   + +Q L+ S++  
Sbjct: 2503 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEA 2559

Query: 511  KQGLEQATTDLRLTILELERELEELKERERLL 542
            ++   +A   +R    EL++  ++ +++E LL
Sbjct: 2560 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2591



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 105/401 (26%), Positives = 180/401 (44%), Gaps = 48/401 (11%)

Query: 270  ATVGRWAAEQRKDLTRLS-KHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRR- 327
            A   R   E  ++L R   K  EALR +L+  E  +     QA   +Q  + E+ ARRR 
Sbjct: 1622 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1681

Query: 328  QAEED---EQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEE 384
            +AEE    ++ L+E E +KQ+ L E +  +   A  E+EL + R  T+  E + Q L+EE
Sbjct: 1682 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA--EQELIRLRAETEQGEQQRQLLEEE 1739

Query: 385  GER----RAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTE----LDKEKAR 436
              R     AAA ++ Q+LE ++ ++ A++++L+     A ++    S +    L+ E  R
Sbjct: 1740 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1799

Query: 437  VDSMVRHQESL-----QAKQRALLKQLDSLDQEREELRGSLDE----AEAQRARVEEQL- 486
               +      L     +AK++  L + D+  Q  E  R   ++     EA R + E ++ 
Sbjct: 1800 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1859

Query: 487  --QSEREQGQCQLRAQQELLQSLQREKQGLE-QATTDLRLTIL------ELEREL----E 533
              + E E  + +  A+ E  Q  + E+Q  + +A  + RL  L      ELER+     +
Sbjct: 1860 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1919

Query: 534  ELKER----ERLLVAFPDLHR----PTETQIHGGRSSSVESQITCPTDSGNVTDHMERQV 585
             L++R    E +L       +      E ++  GR  S         +   +    +RQ+
Sbjct: 1920 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1979

Query: 586  QANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIPQDRL 626
             A + R R  +E   R+Q  L+   E A+Q    L   +RL
Sbjct: 1980 AAEEERRR--REAEERVQKSLAAEEEAARQRKAALEEVERL 2018



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 58/202 (28%), Positives = 99/202 (49%), Gaps = 17/202 (8%)

Query: 291  EALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTET 350
            E LR  + E E +K+ L+++A  L+  LK E+     Q  + EQ L E +  +Q  L+E 
Sbjct: 2450 ERLREAIAELEREKEKLQQEAKLLQ--LKSEE----MQTVQQEQLLQETQALQQSFLSEK 2503

Query: 351  SDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQ 410
              L  +   +E+E  +  +  Q   AKAQQL+EE       +RQ QQ+E++ Q+L A ++
Sbjct: 2504 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE------QQRQQQQMEQERQRLVASME 2557

Query: 411  LLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ-RALLKQLDSLDQEREELR 469
                R   A + V     EL     +++   R QE L A++ + L +QL  L+++     
Sbjct: 2558 EARRRQHEAEEGVRRKQEELQ----QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2613

Query: 470  GSLDEAEAQRARVEEQLQSERE 491
               +E  A +    + L + R+
Sbjct: 2614 AHSEEVTASQVAATKTLPNGRD 2635



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 64/364 (17%), Positives = 163/364 (44%), Gaps = 36/364 (9%)

Query: 269  AATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGAR--R 326
            A  +G W  + R    R  + ++A+   L +++  ++ LR++   LE+  +  +     +
Sbjct: 1220 ADPLGAWLQDAR----RRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1273

Query: 327  RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGE 386
            R A++    + ++E    QL+T  + L+  +A+  ++ K Q  S   ++          E
Sbjct: 1274 RFAKQYINAIKDYE---LQLVTYKAQLEP-VASPAKKPKVQSGSESVIQEYVDLRTHYSE 1329

Query: 387  RRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQES 446
                  + ++ + E ++++E + +L   +     +++      L+K++   ++  + +  
Sbjct: 1330 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ 1389

Query: 447  LQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQS 506
             + + + L +++      REE   +  +A+ Q+  ++E+LQ  R+  + +++A+    ++
Sbjct: 1390 AEREAKELQQRMQEEVVRREE---AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1446

Query: 507  LQREKQGLEQATTDLRLTILELER-------ELEELKERERLLVA--------FPDLHRP 551
             +R +  +E+    +RL +   ER       EL+ L+ R     A           L R 
Sbjct: 1447 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1506

Query: 552  TETQIHGGRSSSVE--SQITCPTDSGNVTDHMERQVQA-NDIRIRVLQEENGRLQSMLSK 608
             + +    R + VE  S++    ++       +R +QA  ++R++  + E    Q+ + +
Sbjct: 1507 VQDESQRKRQAEVELASRVKAEAEAAR---EKQRALQALEELRLQAEEAERRLRQAEVER 1563

Query: 609  IREV 612
             R+V
Sbjct: 1564 ARQV 1567



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 72/308 (23%), Positives = 126/308 (40%), Gaps = 56/308 (18%)

Query: 282  DLTRLSKHVEALRAQLEEAEGQKDGLRKQ---AGKLEQALKQEQGAR----RRQAEEDEQ 334
            +L      ++ LRAQ E  +   D LR +   A ++ + L+Q  G R     R  E   Q
Sbjct: 1128 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1187

Query: 335  CLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGER-RAAAER 393
             L  W    Q +L +T   + ++  L R+L+  RES   + A  Q  +   E+ +A    
Sbjct: 1188 LLERW----QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1243

Query: 394  QVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQ----- 448
              Q + EQ++Q +A ++ +    E   +   +A   ++  K     +V ++  L+     
Sbjct: 1244 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1303

Query: 449  AKQRALLKQLDSLDQEREELRGSLDE-------------------------AEAQRARVE 483
            AK+  +    +S+ QE  +LR    E                         AE QRA   
Sbjct: 1304 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1363

Query: 484  EQL---------QSEREQGQCQLRAQ-----QELLQSLQREKQGLEQATTDLRLTILELE 529
            E+L         Q +  +   Q +AQ     +EL Q +Q E    E+A  D +     ++
Sbjct: 1364 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423

Query: 530  RELEELKE 537
             EL++L++
Sbjct: 1424 EELQQLRQ 1431



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 75/305 (24%), Positives = 137/305 (44%), Gaps = 32/305 (10%)

Query: 250  SLGQFQQLVQDSMGLRPLPAATVGRWAAE-QRKDLTRLSKHVEALRAQLEEAEG--QKDG 306
            SL  +Q L +D   +R    AT      E QR+ L  L  H +A     ++A G   +D 
Sbjct: 896  SLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR 955

Query: 307  L--RKQAGKLEQALKQEQGARRRQAEED---EQCLSEWEHDKQQL-LTETSDLKTKMATL 360
            L   ++ G      +Q   +  + A+E+   ++C+SE +  + QL   ET  +      L
Sbjct: 956  LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 1015

Query: 361  E----RELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQ---VQQLEAQVQLLV 413
            +    RE  Q+    Q  +A+ + L +   R +A   +V  L E       L ++++L +
Sbjct: 1016 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1075

Query: 414  GRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLD 473
            G+LE   Q    ++  L+K K  +  ++R  +  +   RA  +QL    +E + +  +L 
Sbjct: 1076 GKLE---QVRSLSAIYLEKLKT-ISLVIRGTQGAEEVLRAHEEQL----KEAQAVPATLP 1127

Query: 474  EAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELE 533
            E EA +A +++         + Q  AQQ    +L+ E +G ++    L+    E + E+E
Sbjct: 1128 ELEATKASLKKL--------RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1179

Query: 534  ELKER 538
              +ER
Sbjct: 1180 RWRER 1184



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 44/141 (31%), Positives = 65/141 (46%), Gaps = 13/141 (9%)

Query: 396  QQLEEQVQQLEAQVQLLVGRLE----GAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ 451
            Q+ +E V +LEAQ Q LV             + W S   D +  R  S+   +     +Q
Sbjct: 867  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 926

Query: 452  RALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQ--- 508
            R  L  L+   Q    LR S D   A     E++L +ERE G C    QQ LLQSL+   
Sbjct: 927  RQALHSLELHYQAF--LRDSQD---AGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGA 980

Query: 509  REKQGLEQATTDLRLTILELE 529
            +E+   ++  ++L+   L+LE
Sbjct: 981  QEESRCQRCISELKDIRLQLE 1001



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 30/158 (18%), Positives = 67/158 (42%), Gaps = 5/158 (3%)

Query: 253  QFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAG 312
            + +QL QD +           R   +  ++  RL   +E  R +  EAE      +++  
Sbjct: 2519 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2578

Query: 313  KLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQ 372
            +LEQ  +Q++     + +   + L   E   +  L  + ++        + L   R++  
Sbjct: 2579 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2638

Query: 373  AVEAKAQ-QLQEEGERRAAAERQVQQL----EEQVQQL 405
               A+A+ +   +G RR  + +++Q+      E++Q+L
Sbjct: 2639 GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2676


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 95/413 (23%), Positives = 180/413 (43%), Gaps = 44/413 (10%)

Query: 225  ASVQGSLQKVGKVVISLCQSQN--LPSSLGQFQQLVQDSMGLRP-LPAATVGRWAAEQRK 281
            A ++  L ++ K   S  + Q   +  +L Q +Q+ ++ + L+     A  G+  AE   
Sbjct: 1889 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELEL 1946

Query: 282  DLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQ----CLS 337
            +L R+  + E      E+AE        +A +  Q L  E+  RRR+AEE  Q       
Sbjct: 1947 ELGRIRSNAEDTLRSKEQAE-------LEAARQRQ-LAAEEERRRREAEERVQKSLAAEE 1998

Query: 338  EWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQL-QEEGERRAAAERQ-- 394
            E    ++  L E   LK K+     E ++ RE  +   A+  QL QE  ++R  AE +  
Sbjct: 1999 EAARQRKAALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2054

Query: 395  ---VQQLEEQVQQLEAQVQLLVGRLEG-------AGQQVCWASTELDKEKARVDSMVRHQ 444
               VQQ E+++QQ   Q Q ++ +L G       A ++   A  + ++E A+    V   
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114

Query: 445  ESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELL 504
            E L+       +         E+LR   ++  A+RA+ E+    +++    ++   ++  
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174

Query: 505  QSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSV 564
            +   R+K  +EQ  T LRL + E + +   L E  + L A        E      + S V
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA--------EATEAARQRSQV 2226

Query: 565  ESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGR--LQSMLSKIREVAQQ 615
            E ++            ++ +++A +  + +  ++N +  LQ    K+++VA++
Sbjct: 2227 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 94/412 (22%), Positives = 178/412 (43%), Gaps = 47/412 (11%)

Query: 243  QSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEG 302
            Q +++   L Q +Q  +  +  +   A    R      +++  +   +EA   Q   AEG
Sbjct: 1414 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473

Query: 303  QKDGLRKQAGKLEQALKQ--EQGARRRQAEEDE---------------QCLSEWEHDKQQ 345
            +   LR +A + E   +Q  E+  R R+  +DE               +  +E   +KQ+
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533

Query: 346  LLTETSDLKTKMATLERELKQ-QRESTQAVEAKAQQLQEEGE-----RRAAAERQVQQLE 399
             L    +L+ +    ER L+Q + E  + V+   +  Q   E     +RA+   +  QLE
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593

Query: 400  EQVQQLEAQVQLLVGRLEGAGQQVC-------WASTELDKEKARVDSMVRHQESLQAKQR 452
              +Q+    V  L    E   QQ          A  EL++ + + +  +R +  LQA++ 
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR--LQAEEV 1651

Query: 453  ALLKQLDSLDQEREELRGSLDEAEAQ---RARVEEQLQSEREQGQCQLRAQQELLQSLQR 509
            A  K L   + E+++     +EAE +   R + EEQ   +RE  + +L  Q++L +   +
Sbjct: 1652 AQQKSLAQAEAEKQK-----EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706

Query: 510  EKQGLEQATTDLRLTIL--ELEREL--EELKERERLLVAFPDLHRPTETQIHGGRSSS-- 563
            ++   EQ    LR      E +R+L  EEL   +R   A     +  E ++   R+    
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1766

Query: 564  -VESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQ 614
             + S+     +S + ++  +++++A   R R L EE  RL+++  + +   Q
Sbjct: 1767 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1818



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 77/313 (24%), Positives = 144/313 (46%), Gaps = 49/313 (15%)

Query: 327  RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATL-ERELKQQRESTQAVEAKAQQLQEEG 385
            R+ EE+E+   +   ++++ L E      K   L E   + + ++ +  +   Q++QEE 
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401

Query: 386  ERRAAA----ERQVQQLEEQVQQL----EAQVQLLVGRLEGAGQQVCWASTELDKEKARV 437
             RR  A    ++Q + ++E++QQL    EA++Q    + E A           ++ + R+
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA-----------ERSRLRI 1450

Query: 438  DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQ----G 493
            +  +R    ++ +  A  +Q    + E + LR   +EAEAQ+ + +E+ +  R Q     
Sbjct: 1451 EEEIR---VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507

Query: 494  QCQLRAQQELLQSLQ------REKQGLEQATTDLRLTILELERELE--ELKERERLLVAF 545
            Q + +A+ EL   ++      REKQ   QA  +LRL   E ER L   E++   ++ VA 
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1567

Query: 546  PDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEE---NGRL 602
                R  E ++   R+S  E            T  +ER +Q   + +  L+EE     + 
Sbjct: 1568 ETAQRSAEAELQSKRASFAEK-----------TAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 603  QSMLSKIREVAQQ 615
            Q+   + RE A++
Sbjct: 1617 QAEAERAREEAER 1629



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 74/272 (27%), Positives = 127/272 (46%), Gaps = 13/272 (4%)

Query: 277  AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
            AE+R+ L  +   +E  R QL EA  Q     ++  K  Q   QE+  RR +A  D Q  
Sbjct: 1356 AEERERLAEVEAALEKQR-QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1414

Query: 337  SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEG--ERRAAAERQ 394
                 ++ Q L ++S+ + +    + E  ++       E +  +LQ E    +R  AE +
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474

Query: 395  VQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQ-ESLQAKQRA 453
            +Q L  + ++ EAQ +      E   +QV   S    + +  + S V+ + E+ + KQRA
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534

Query: 454  LLKQLDSLDQEREELRGSLDEAEAQRAR-VEEQLQSEREQGQCQLRAQQ----ELLQSLQ 508
            L + L+ L  + EE    L +AE +RAR V+  L++ +   + +L++++    E    L+
Sbjct: 1535 L-QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593

Query: 509  REKQGLEQATTDLRLTILELERELEELKERER 540
            R  Q    A   LR    E ER  ++  E ER
Sbjct: 1594 RSLQEEHVAVAQLR---EEAERRAQQQAEAER 1622



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 73/287 (25%), Positives = 136/287 (47%), Gaps = 24/287 (8%)

Query: 276  AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKL-------EQALKQEQGARRRQ 328
            A E  +  +++ + + ++R Q+EE    K  +  +   L        Q   QE+  + +Q
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2275

Query: 329  AEEDEQCLSEWEHDKQQL--LTETSDLKTKMATLERELKQQRESTQA---VEAKAQQLQE 383
              E+   LS    +  +L  L E  DL  + A  E+ LK++ ++ Q    ++A+A+ LQ+
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAE-EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334

Query: 384  EGERRAAAERQVQQLEEQV-QQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVR 442
            + E      R++Q+ +EQ+ QQL  + Q     LE   Q+    S E ++ K RV  M R
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394

Query: 443  HQESLQAKQRALLKQLDSLDQE--REELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQ 500
             Q   +   +   KQ + + ++  R EL      A  ++  + + L+ +R+Q        
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTEL------ATQEKVTLVQTLEIQRQQSDHDAERL 2448

Query: 501  QELLQSLQREKQGLEQATTDLRLTILELERELEE--LKERERLLVAF 545
            +E +  L+REK+ L+Q    L+L   E++   +E  L+E + L  +F
Sbjct: 2449 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2495



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 74/270 (27%), Positives = 124/270 (45%), Gaps = 23/270 (8%)

Query: 292  ALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGA---RRRQAEEDEQCLSEWEHDKQQLLT 348
            A R+   E + ++    ++  +LE++L++E  A    R +AE   Q  +E E  +++   
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629

Query: 349  ETS--DLKTKMATLER----ELKQQRESTQA-VEAKAQQLQEEGERRAAAERQ-VQQLEE 400
            E     LK   A   R    E+ QQ+   QA  E + ++ + E  RR  AE Q V+Q E 
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1689

Query: 401  QVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDS 460
              Q+LE Q QL     EG  QQ   A  EL + +A  +   + ++ L+ +   L ++  +
Sbjct: 1690 AEQELEKQRQLA----EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745

Query: 461  LDQEREELRGSLDEAEAQ-------RARVEEQLQSEREQGQCQLRAQQELLQSLQREKQG 513
              Q+R+EL   L +  A+       +AR EE+ +S  E+ + +L A+    + L  E   
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805

Query: 514  LEQATTDL-RLTILELERELEELKERERLL 542
            L     +  R   L  E    +  E ER+L
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQRAEAERVL 1835



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 69/332 (20%), Positives = 152/332 (45%), Gaps = 26/332 (7%)

Query: 227  VQGSLQKVGKVVISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRL 286
            +Q   +K+ +V     +         + +QL ++ +  +   A  + +   +  ++ TRL
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325

Query: 287  SKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQL 346
                E L+ Q E A+ Q   L++   ++ Q L +E    +R  E + Q        + ++
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ-------RQLEM 2378

Query: 347  LTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQ----VQQLEEQV 402
              E   LK ++A + R   +  E  Q    +A+++ E+  R   A ++    VQ LE Q 
Sbjct: 2379 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2438

Query: 403  QQLEAQVQLL---VGRLEGAGQQVCWASTELDKEKARVDSMVRHQ--ESLQAKQRALLKQ 457
            QQ +   + L   +  LE   +++   +  L  +   + ++ + Q  +  QA Q++ L +
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498

Query: 458  LDSL-------DQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQRE 510
             DSL       +QE+ +L     +  A+  ++ E+ Q +++Q +   + +Q L+ S++  
Sbjct: 2499 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEA 2555

Query: 511  KQGLEQATTDLRLTILELERELEELKERERLL 542
            ++   +A   +R    EL++  ++ +++E LL
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 105/401 (26%), Positives = 180/401 (44%), Gaps = 48/401 (11%)

Query: 270  ATVGRWAAEQRKDLTRLS-KHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRR- 327
            A   R   E  ++L R   K  EALR +L+  E  +     QA   +Q  + E+ ARRR 
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1677

Query: 328  QAEED---EQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEE 384
            +AEE    ++ L+E E +KQ+ L E +  +   A  E+EL + R  T+  E + Q L+EE
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA--EQELIRLRAETEQGEQQRQLLEEE 1735

Query: 385  GER----RAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTE----LDKEKAR 436
              R     AAA ++ Q+LE ++ ++ A++++L+     A ++    S +    L+ E  R
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1795

Query: 437  VDSMVRHQESL-----QAKQRALLKQLDSLDQEREELRGSLDE----AEAQRARVEEQL- 486
               +      L     +AK++  L + D+  Q  E  R   ++     EA R + E ++ 
Sbjct: 1796 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855

Query: 487  --QSEREQGQCQLRAQQELLQSLQREKQGLE-QATTDLRLTIL------ELEREL----E 533
              + E E  + +  A+ E  Q  + E+Q  + +A  + RL  L      ELER+     +
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915

Query: 534  ELKER----ERLLVAFPDLHR----PTETQIHGGRSSSVESQITCPTDSGNVTDHMERQV 585
             L++R    E +L       +      E ++  GR  S         +   +    +RQ+
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975

Query: 586  QANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIPQDRL 626
             A + R R  +E   R+Q  L+   E A+Q    L   +RL
Sbjct: 1976 AAEEERRR--REAEERVQKSLAAEEEAARQRKAALEEVERL 2014



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 58/202 (28%), Positives = 99/202 (49%), Gaps = 17/202 (8%)

Query: 291  EALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTET 350
            E LR  + E E +K+ L+++A  L+  LK E+     Q  + EQ L E +  +Q  L+E 
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQ--LKSEE----MQTVQQEQLLQETQALQQSFLSEK 2499

Query: 351  SDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQ 410
              L  +   +E+E  +  +  Q   AKAQQL+EE       +RQ QQ+E++ Q+L A ++
Sbjct: 2500 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE------QQRQQQQMEQERQRLVASME 2553

Query: 411  LLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ-RALLKQLDSLDQEREELR 469
                R   A + V     EL     +++   R QE L A++ + L +QL  L+++     
Sbjct: 2554 EARRRQHEAEEGVRRKQEELQ----QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2609

Query: 470  GSLDEAEAQRARVEEQLQSERE 491
               +E  A +    + L + R+
Sbjct: 2610 AHSEEVTASQVAATKTLPNGRD 2631



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 64/364 (17%), Positives = 163/364 (44%), Gaps = 36/364 (9%)

Query: 269  AATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGAR--R 326
            A  +G W  + R    R  + ++A+   L +++  ++ LR++   LE+  +  +     +
Sbjct: 1216 ADPLGAWLQDAR----RRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1269

Query: 327  RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGE 386
            R A++    + ++E    QL+T  + L+  +A+  ++ K Q  S   ++          E
Sbjct: 1270 RFAKQYINAIKDYE---LQLVTYKAQLEP-VASPAKKPKVQSGSESVIQEYVDLRTHYSE 1325

Query: 387  RRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQES 446
                  + ++ + E ++++E + +L   +     +++      L+K++   ++  + +  
Sbjct: 1326 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ 1385

Query: 447  LQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQS 506
             + + + L +++      REE   +  +A+ Q+  ++E+LQ  R+  + +++A+    ++
Sbjct: 1386 AEREAKELQQRMQEEVVRREE---AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442

Query: 507  LQREKQGLEQATTDLRLTILELER-------ELEELKERERLLVA--------FPDLHRP 551
             +R +  +E+    +RL +   ER       EL+ L+ R     A           L R 
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502

Query: 552  TETQIHGGRSSSVE--SQITCPTDSGNVTDHMERQVQA-NDIRIRVLQEENGRLQSMLSK 608
             + +    R + VE  S++    ++       +R +QA  ++R++  + E    Q+ + +
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAR---EKQRALQALEELRLQAEEAERRLRQAEVER 1559

Query: 609  IREV 612
             R+V
Sbjct: 1560 ARQV 1563



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 72/308 (23%), Positives = 126/308 (40%), Gaps = 56/308 (18%)

Query: 282  DLTRLSKHVEALRAQLEEAEGQKDGLRKQ---AGKLEQALKQEQGAR----RRQAEEDEQ 334
            +L      ++ LRAQ E  +   D LR +   A ++ + L+Q  G R     R  E   Q
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1183

Query: 335  CLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGER-RAAAER 393
             L  W    Q +L +T   + ++  L R+L+  RES   + A  Q  +   E+ +A    
Sbjct: 1184 LLERW----QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1239

Query: 394  QVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQ----- 448
              Q + EQ++Q +A ++ +    E   +   +A   ++  K     +V ++  L+     
Sbjct: 1240 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1299

Query: 449  AKQRALLKQLDSLDQEREELRGSLDE-------------------------AEAQRARVE 483
            AK+  +    +S+ QE  +LR    E                         AE QRA   
Sbjct: 1300 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359

Query: 484  EQL---------QSEREQGQCQLRAQ-----QELLQSLQREKQGLEQATTDLRLTILELE 529
            E+L         Q +  +   Q +AQ     +EL Q +Q E    E+A  D +     ++
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419

Query: 530  RELEELKE 537
             EL++L++
Sbjct: 1420 EELQQLRQ 1427



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 75/305 (24%), Positives = 137/305 (44%), Gaps = 32/305 (10%)

Query: 250  SLGQFQQLVQDSMGLRPLPAATVGRWAAE-QRKDLTRLSKHVEALRAQLEEAEG--QKDG 306
            SL  +Q L +D   +R    AT      E QR+ L  L  H +A     ++A G   +D 
Sbjct: 892  SLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR 951

Query: 307  L--RKQAGKLEQALKQEQGARRRQAEED---EQCLSEWEHDKQQL-LTETSDLKTKMATL 360
            L   ++ G      +Q   +  + A+E+   ++C+SE +  + QL   ET  +      L
Sbjct: 952  LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 1011

Query: 361  E----RELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQ---VQQLEAQVQLLV 413
            +    RE  Q+    Q  +A+ + L +   R +A   +V  L E       L ++++L +
Sbjct: 1012 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1071

Query: 414  GRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLD 473
            G+LE   Q    ++  L+K K  +  ++R  +  +   RA  +QL    +E + +  +L 
Sbjct: 1072 GKLE---QVRSLSAIYLEKLKT-ISLVIRGTQGAEEVLRAHEEQL----KEAQAVPATLP 1123

Query: 474  EAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELE 533
            E EA +A +++         + Q  AQQ    +L+ E +G ++    L+    E + E+E
Sbjct: 1124 ELEATKASLKKL--------RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1175

Query: 534  ELKER 538
              +ER
Sbjct: 1176 RWRER 1180



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 44/141 (31%), Positives = 65/141 (46%), Gaps = 13/141 (9%)

Query: 396 QQLEEQVQQLEAQVQLLVGRLE----GAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ 451
           Q+ +E V +LEAQ Q LV             + W S   D +  R  S+   +     +Q
Sbjct: 863 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 922

Query: 452 RALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQ--- 508
           R  L  L+   Q    LR S D   A     E++L +ERE G C    QQ LLQSL+   
Sbjct: 923 RQALHSLELHYQAF--LRDSQD---AGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGA 976

Query: 509 REKQGLEQATTDLRLTILELE 529
           +E+   ++  ++L+   L+LE
Sbjct: 977 QEESRCQRCISELKDIRLQLE 997



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 30/158 (18%), Positives = 67/158 (42%), Gaps = 5/158 (3%)

Query: 253  QFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAG 312
            + +QL QD +           R   +  ++  RL   +E  R +  EAE      +++  
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574

Query: 313  KLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQ 372
            +LEQ  +Q++     + +   + L   E   +  L  + ++        + L   R++  
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2634

Query: 373  AVEAKAQ-QLQEEGERRAAAERQVQQL----EEQVQQL 405
               A+A+ +   +G RR  + +++Q+      E++Q+L
Sbjct: 2635 GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2672


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 95/413 (23%), Positives = 180/413 (43%), Gaps = 44/413 (10%)

Query: 225  ASVQGSLQKVGKVVISLCQSQN--LPSSLGQFQQLVQDSMGLRP-LPAATVGRWAAEQRK 281
            A ++  L ++ K   S  + Q   +  +L Q +Q+ ++ + L+     A  G+  AE   
Sbjct: 1857 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELEL 1914

Query: 282  DLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQ----CLS 337
            +L R+  + E      E+AE        +A +  Q L  E+  RRR+AEE  Q       
Sbjct: 1915 ELGRIRSNAEDTLRSKEQAE-------LEAARQRQ-LAAEEERRRREAEERVQKSLAAEE 1966

Query: 338  EWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQL-QEEGERRAAAERQ-- 394
            E    ++  L E   LK K+     E ++ RE  +   A+  QL QE  ++R  AE +  
Sbjct: 1967 EAARQRKAALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2022

Query: 395  ---VQQLEEQVQQLEAQVQLLVGRLEG-------AGQQVCWASTELDKEKARVDSMVRHQ 444
               VQQ E+++QQ   Q Q ++ +L G       A ++   A  + ++E A+    V   
Sbjct: 2023 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2082

Query: 445  ESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELL 504
            E L+       +         E+LR   ++  A+RA+ E+    +++    ++   ++  
Sbjct: 2083 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2142

Query: 505  QSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSV 564
            +   R+K  +EQ  T LRL + E + +   L E  + L A        E      + S V
Sbjct: 2143 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA--------EATEAARQRSQV 2194

Query: 565  ESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGR--LQSMLSKIREVAQQ 615
            E ++            ++ +++A +  + +  ++N +  LQ    K+++VA++
Sbjct: 2195 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2247



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 94/412 (22%), Positives = 178/412 (43%), Gaps = 47/412 (11%)

Query: 243  QSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEG 302
            Q +++   L Q +Q  +  +  +   A    R      +++  +   +EA   Q   AEG
Sbjct: 1382 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1441

Query: 303  QKDGLRKQAGKLEQALKQ--EQGARRRQAEEDE---------------QCLSEWEHDKQQ 345
            +   LR +A + E   +Q  E+  R R+  +DE               +  +E   +KQ+
Sbjct: 1442 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1501

Query: 346  LLTETSDLKTKMATLERELKQ-QRESTQAVEAKAQQLQEEGE-----RRAAAERQVQQLE 399
             L    +L+ +    ER L+Q + E  + V+   +  Q   E     +RA+   +  QLE
Sbjct: 1502 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1561

Query: 400  EQVQQLEAQVQLLVGRLEGAGQQVC-------WASTELDKEKARVDSMVRHQESLQAKQR 452
              +Q+    V  L    E   QQ          A  EL++ + + +  +R +  LQA++ 
Sbjct: 1562 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR--LQAEEV 1619

Query: 453  ALLKQLDSLDQEREELRGSLDEAEAQ---RARVEEQLQSEREQGQCQLRAQQELLQSLQR 509
            A  K L   + E+++     +EAE +   R + EEQ   +RE  + +L  Q++L +   +
Sbjct: 1620 AQQKSLAQAEAEKQK-----EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1674

Query: 510  EKQGLEQATTDLRLTIL--ELEREL--EELKERERLLVAFPDLHRPTETQIHGGRSSS-- 563
            ++   EQ    LR      E +R+L  EEL   +R   A     +  E ++   R+    
Sbjct: 1675 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1734

Query: 564  -VESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQ 614
             + S+     +S + ++  +++++A   R R L EE  RL+++  + +   Q
Sbjct: 1735 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1786



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 77/313 (24%), Positives = 144/313 (46%), Gaps = 49/313 (15%)

Query: 327  RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATL-ERELKQQRESTQAVEAKAQQLQEEG 385
            R+ EE+E+   +   ++++ L E      K   L E   + + ++ +  +   Q++QEE 
Sbjct: 1310 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1369

Query: 386  ERRAAA----ERQVQQLEEQVQQL----EAQVQLLVGRLEGAGQQVCWASTELDKEKARV 437
             RR  A    ++Q + ++E++QQL    EA++Q    + E A           ++ + R+
Sbjct: 1370 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA-----------ERSRLRI 1418

Query: 438  DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQ----G 493
            +  +R    ++ +  A  +Q    + E + LR   +EAEAQ+ + +E+ +  R Q     
Sbjct: 1419 EEEIR---VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1475

Query: 494  QCQLRAQQELLQSLQ------REKQGLEQATTDLRLTILELERELE--ELKERERLLVAF 545
            Q + +A+ EL   ++      REKQ   QA  +LRL   E ER L   E++   ++ VA 
Sbjct: 1476 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1535

Query: 546  PDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEE---NGRL 602
                R  E ++   R+S  E            T  +ER +Q   + +  L+EE     + 
Sbjct: 1536 ETAQRSAEAELQSKRASFAEK-----------TAQLERSLQEEHVAVAQLREEAERRAQQ 1584

Query: 603  QSMLSKIREVAQQ 615
            Q+   + RE A++
Sbjct: 1585 QAEAERAREEAER 1597



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 74/272 (27%), Positives = 127/272 (46%), Gaps = 13/272 (4%)

Query: 277  AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
            AE+R+ L  +   +E  R QL EA  Q     ++  K  Q   QE+  RR +A  D Q  
Sbjct: 1324 AEERERLAEVEAALEKQR-QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1382

Query: 337  SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEG--ERRAAAERQ 394
                 ++ Q L ++S+ + +    + E  ++       E +  +LQ E    +R  AE +
Sbjct: 1383 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1442

Query: 395  VQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQ-ESLQAKQRA 453
            +Q L  + ++ EAQ +      E   +QV   S    + +  + S V+ + E+ + KQRA
Sbjct: 1443 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1502

Query: 454  LLKQLDSLDQEREELRGSLDEAEAQRAR-VEEQLQSEREQGQCQLRAQQ----ELLQSLQ 508
            L + L+ L  + EE    L +AE +RAR V+  L++ +   + +L++++    E    L+
Sbjct: 1503 L-QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1561

Query: 509  REKQGLEQATTDLRLTILELERELEELKERER 540
            R  Q    A   LR    E ER  ++  E ER
Sbjct: 1562 RSLQEEHVAVAQLR---EEAERRAQQQAEAER 1590



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 73/287 (25%), Positives = 136/287 (47%), Gaps = 24/287 (8%)

Query: 276  AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKL-------EQALKQEQGARRRQ 328
            A E  +  +++ + + ++R Q+EE    K  +  +   L        Q   QE+  + +Q
Sbjct: 2184 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2243

Query: 329  AEEDEQCLSEWEHDKQQL--LTETSDLKTKMATLERELKQQRESTQA---VEAKAQQLQE 383
              E+   LS    +  +L  L E  DL  + A  E+ LK++ ++ Q    ++A+A+ LQ+
Sbjct: 2244 VAEEAARLSVAAQEAARLRQLAE-EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2302

Query: 384  EGERRAAAERQVQQLEEQV-QQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVR 442
            + E      R++Q+ +EQ+ QQL  + Q     LE   Q+    S E ++ K RV  M R
Sbjct: 2303 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2362

Query: 443  HQESLQAKQRALLKQLDSLDQE--REELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQ 500
             Q   +   +   KQ + + ++  R EL      A  ++  + + L+ +R+Q        
Sbjct: 2363 AQARAEEDAQRFRKQAEEIGEKLHRTEL------ATQEKVTLVQTLEIQRQQSDHDAERL 2416

Query: 501  QELLQSLQREKQGLEQATTDLRLTILELERELEE--LKERERLLVAF 545
            +E +  L+REK+ L+Q    L+L   E++   +E  L+E + L  +F
Sbjct: 2417 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2463



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 74/270 (27%), Positives = 124/270 (45%), Gaps = 23/270 (8%)

Query: 292  ALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGA---RRRQAEEDEQCLSEWEHDKQQLLT 348
            A R+   E + ++    ++  +LE++L++E  A    R +AE   Q  +E E  +++   
Sbjct: 1538 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1597

Query: 349  ETS--DLKTKMATLER----ELKQQRESTQA-VEAKAQQLQEEGERRAAAERQ-VQQLEE 400
            E     LK   A   R    E+ QQ+   QA  E + ++ + E  RR  AE Q V+Q E 
Sbjct: 1598 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1657

Query: 401  QVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDS 460
              Q+LE Q QL     EG  QQ   A  EL + +A  +   + ++ L+ +   L ++  +
Sbjct: 1658 AEQELEKQRQLA----EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1713

Query: 461  LDQEREELRGSLDEAEAQ-------RARVEEQLQSEREQGQCQLRAQQELLQSLQREKQG 513
              Q+R+EL   L +  A+       +AR EE+ +S  E+ + +L A+    + L  E   
Sbjct: 1714 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1773

Query: 514  LEQATTDL-RLTILELERELEELKERERLL 542
            L     +  R   L  E    +  E ER+L
Sbjct: 1774 LRALAEEAKRQRQLAEEDAARQRAEAERVL 1803



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 69/332 (20%), Positives = 152/332 (45%), Gaps = 26/332 (7%)

Query: 227  VQGSLQKVGKVVISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRL 286
            +Q   +K+ +V     +         + +QL ++ +  +   A  + +   +  ++ TRL
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293

Query: 287  SKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQL 346
                E L+ Q E A+ Q   L++   ++ Q L +E    +R  E + Q        + ++
Sbjct: 2294 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ-------RQLEM 2346

Query: 347  LTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQ----VQQLEEQV 402
              E   LK ++A + R   +  E  Q    +A+++ E+  R   A ++    VQ LE Q 
Sbjct: 2347 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2406

Query: 403  QQLEAQVQLL---VGRLEGAGQQVCWASTELDKEKARVDSMVRHQ--ESLQAKQRALLKQ 457
            QQ +   + L   +  LE   +++   +  L  +   + ++ + Q  +  QA Q++ L +
Sbjct: 2407 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2466

Query: 458  LDSL-------DQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQRE 510
             DSL       +QE+ +L     +  A+  ++ E+ Q +++Q +   + +Q L+ S++  
Sbjct: 2467 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEA 2523

Query: 511  KQGLEQATTDLRLTILELERELEELKERERLL 542
            ++   +A   +R    EL++  ++ +++E LL
Sbjct: 2524 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2555



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 105/401 (26%), Positives = 180/401 (44%), Gaps = 48/401 (11%)

Query: 270  ATVGRWAAEQRKDLTRLS-KHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRR- 327
            A   R   E  ++L R   K  EALR +L+  E  +     QA   +Q  + E+ ARRR 
Sbjct: 1586 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1645

Query: 328  QAEED---EQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEE 384
            +AEE    ++ L+E E +KQ+ L E +  +   A  E+EL + R  T+  E + Q L+EE
Sbjct: 1646 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA--EQELIRLRAETEQGEQQRQLLEEE 1703

Query: 385  GER----RAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTE----LDKEKAR 436
              R     AAA ++ Q+LE ++ ++ A++++L+     A ++    S +    L+ E  R
Sbjct: 1704 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1763

Query: 437  VDSMVRHQESL-----QAKQRALLKQLDSLDQEREELRGSLDE----AEAQRARVEEQL- 486
               +      L     +AK++  L + D+  Q  E  R   ++     EA R + E ++ 
Sbjct: 1764 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1823

Query: 487  --QSEREQGQCQLRAQQELLQSLQREKQGLE-QATTDLRLTIL------ELEREL----E 533
              + E E  + +  A+ E  Q  + E+Q  + +A  + RL  L      ELER+     +
Sbjct: 1824 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1883

Query: 534  ELKER----ERLLVAFPDLHR----PTETQIHGGRSSSVESQITCPTDSGNVTDHMERQV 585
             L++R    E +L       +      E ++  GR  S         +   +    +RQ+
Sbjct: 1884 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1943

Query: 586  QANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIPQDRL 626
             A + R R  +E   R+Q  L+   E A+Q    L   +RL
Sbjct: 1944 AAEEERRR--REAEERVQKSLAAEEEAARQRKAALEEVERL 1982



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 58/202 (28%), Positives = 99/202 (49%), Gaps = 17/202 (8%)

Query: 291  EALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTET 350
            E LR  + E E +K+ L+++A  L+  LK E+     Q  + EQ L E +  +Q  L+E 
Sbjct: 2414 ERLREAIAELEREKEKLQQEAKLLQ--LKSEE----MQTVQQEQLLQETQALQQSFLSEK 2467

Query: 351  SDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQ 410
              L  +   +E+E  +  +  Q   AKAQQL+EE       +RQ QQ+E++ Q+L A ++
Sbjct: 2468 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE------QQRQQQQMEQERQRLVASME 2521

Query: 411  LLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ-RALLKQLDSLDQEREELR 469
                R   A + V     EL     +++   R QE L A++ + L +QL  L+++     
Sbjct: 2522 EARRRQHEAEEGVRRKQEELQ----QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2577

Query: 470  GSLDEAEAQRARVEEQLQSERE 491
               +E  A +    + L + R+
Sbjct: 2578 AHSEEVTASQVAATKTLPNGRD 2599



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 64/364 (17%), Positives = 163/364 (44%), Gaps = 36/364 (9%)

Query: 269  AATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGAR--R 326
            A  +G W  + R    R  + ++A+   L +++  ++ LR++   LE+  +  +     +
Sbjct: 1184 ADPLGAWLQDAR----RRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1237

Query: 327  RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGE 386
            R A++    + ++E    QL+T  + L+  +A+  ++ K Q  S   ++          E
Sbjct: 1238 RFAKQYINAIKDYE---LQLVTYKAQLEP-VASPAKKPKVQSGSESVIQEYVDLRTHYSE 1293

Query: 387  RRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQES 446
                  + ++ + E ++++E + +L   +     +++      L+K++   ++  + +  
Sbjct: 1294 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ 1353

Query: 447  LQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQS 506
             + + + L +++      REE   +  +A+ Q+  ++E+LQ  R+  + +++A+    ++
Sbjct: 1354 AEREAKELQQRMQEEVVRREE---AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1410

Query: 507  LQREKQGLEQATTDLRLTILELER-------ELEELKERERLLVA--------FPDLHRP 551
             +R +  +E+    +RL +   ER       EL+ L+ R     A           L R 
Sbjct: 1411 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1470

Query: 552  TETQIHGGRSSSVE--SQITCPTDSGNVTDHMERQVQA-NDIRIRVLQEENGRLQSMLSK 608
             + +    R + VE  S++    ++       +R +QA  ++R++  + E    Q+ + +
Sbjct: 1471 VQDESQRKRQAEVELASRVKAEAEAAR---EKQRALQALEELRLQAEEAERRLRQAEVER 1527

Query: 609  IREV 612
             R+V
Sbjct: 1528 ARQV 1531



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 72/308 (23%), Positives = 126/308 (40%), Gaps = 56/308 (18%)

Query: 282  DLTRLSKHVEALRAQLEEAEGQKDGLRKQ---AGKLEQALKQEQGAR----RRQAEEDEQ 334
            +L      ++ LRAQ E  +   D LR +   A ++ + L+Q  G R     R  E   Q
Sbjct: 1092 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1151

Query: 335  CLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGER-RAAAER 393
             L  W    Q +L +T   + ++  L R+L+  RES   + A  Q  +   E+ +A    
Sbjct: 1152 LLERW----QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1207

Query: 394  QVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQ----- 448
              Q + EQ++Q +A ++ +    E   +   +A   ++  K     +V ++  L+     
Sbjct: 1208 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1267

Query: 449  AKQRALLKQLDSLDQEREELRGSLDE-------------------------AEAQRARVE 483
            AK+  +    +S+ QE  +LR    E                         AE QRA   
Sbjct: 1268 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1327

Query: 484  EQL---------QSEREQGQCQLRAQ-----QELLQSLQREKQGLEQATTDLRLTILELE 529
            E+L         Q +  +   Q +AQ     +EL Q +Q E    E+A  D +     ++
Sbjct: 1328 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1387

Query: 530  RELEELKE 537
             EL++L++
Sbjct: 1388 EELQQLRQ 1395



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 75/305 (24%), Positives = 137/305 (44%), Gaps = 32/305 (10%)

Query: 250  SLGQFQQLVQDSMGLRPLPAATVGRWAAE-QRKDLTRLSKHVEALRAQLEEAEG--QKDG 306
            SL  +Q L +D   +R    AT      E QR+ L  L  H +A     ++A G   +D 
Sbjct: 860  SLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR 919

Query: 307  L--RKQAGKLEQALKQEQGARRRQAEED---EQCLSEWEHDKQQL-LTETSDLKTKMATL 360
            L   ++ G      +Q   +  + A+E+   ++C+SE +  + QL   ET  +      L
Sbjct: 920  LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 979

Query: 361  E----RELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQ---VQQLEAQVQLLV 413
            +    RE  Q+    Q  +A+ + L +   R +A   +V  L E       L ++++L +
Sbjct: 980  DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1039

Query: 414  GRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLD 473
            G+LE   Q    ++  L+K K  +  ++R  +  +   RA  +QL    +E + +  +L 
Sbjct: 1040 GKLE---QVRSLSAIYLEKLKT-ISLVIRGTQGAEEVLRAHEEQL----KEAQAVPATLP 1091

Query: 474  EAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELE 533
            E EA +A +++         + Q  AQQ    +L+ E +G ++    L+    E + E+E
Sbjct: 1092 ELEATKASLKKL--------RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1143

Query: 534  ELKER 538
              +ER
Sbjct: 1144 RWRER 1148



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 44/141 (31%), Positives = 65/141 (46%), Gaps = 13/141 (9%)

Query: 396 QQLEEQVQQLEAQVQLLVGRLE----GAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ 451
           Q+ +E V +LEAQ Q LV             + W S   D +  R  S+   +     +Q
Sbjct: 831 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 890

Query: 452 RALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQ--- 508
           R  L  L+   Q    LR S D   A     E++L +ERE G C    QQ LLQSL+   
Sbjct: 891 RQALHSLELHYQAF--LRDSQD---AGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGA 944

Query: 509 REKQGLEQATTDLRLTILELE 529
           +E+   ++  ++L+   L+LE
Sbjct: 945 QEESRCQRCISELKDIRLQLE 965



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 30/158 (18%), Positives = 67/158 (42%), Gaps = 5/158 (3%)

Query: 253  QFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAG 312
            + +QL QD +           R   +  ++  RL   +E  R +  EAE      +++  
Sbjct: 2483 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2542

Query: 313  KLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQ 372
            +LEQ  +Q++     + +   + L   E   +  L  + ++        + L   R++  
Sbjct: 2543 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2602

Query: 373  AVEAKAQ-QLQEEGERRAAAERQVQQL----EEQVQQL 405
               A+A+ +   +G RR  + +++Q+      E++Q+L
Sbjct: 2603 GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2640


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 95/413 (23%), Positives = 180/413 (43%), Gaps = 44/413 (10%)

Query: 225  ASVQGSLQKVGKVVISLCQSQN--LPSSLGQFQQLVQDSMGLRP-LPAATVGRWAAEQRK 281
            A ++  L ++ K   S  + Q   +  +L Q +Q+ ++ + L+     A  G+  AE   
Sbjct: 2026 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELEL 2083

Query: 282  DLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQ----CLS 337
            +L R+  + E      E+AE        +A +  Q L  E+  RRR+AEE  Q       
Sbjct: 2084 ELGRIRSNAEDTLRSKEQAE-------LEAARQRQ-LAAEEERRRREAEERVQKSLAAEE 2135

Query: 338  EWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQL-QEEGERRAAAERQ-- 394
            E    ++  L E   LK K+     E ++ RE  +   A+  QL QE  ++R  AE +  
Sbjct: 2136 EAARQRKAALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2191

Query: 395  ---VQQLEEQVQQLEAQVQLLVGRLEG-------AGQQVCWASTELDKEKARVDSMVRHQ 444
               VQQ E+++QQ   Q Q ++ +L G       A ++   A  + ++E A+    V   
Sbjct: 2192 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2251

Query: 445  ESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELL 504
            E L+       +         E+LR   ++  A+RA+ E+    +++    ++   ++  
Sbjct: 2252 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2311

Query: 505  QSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSV 564
            +   R+K  +EQ  T LRL + E + +   L E  + L A        E      + S V
Sbjct: 2312 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA--------EATEAARQRSQV 2363

Query: 565  ESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGR--LQSMLSKIREVAQQ 615
            E ++            ++ +++A +  + +  ++N +  LQ    K+++VA++
Sbjct: 2364 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2416



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 94/412 (22%), Positives = 178/412 (43%), Gaps = 47/412 (11%)

Query: 243  QSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEG 302
            Q +++   L Q +Q  +  +  +   A    R      +++  +   +EA   Q   AEG
Sbjct: 1551 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1610

Query: 303  QKDGLRKQAGKLEQALKQ--EQGARRRQAEEDE---------------QCLSEWEHDKQQ 345
            +   LR +A + E   +Q  E+  R R+  +DE               +  +E   +KQ+
Sbjct: 1611 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1670

Query: 346  LLTETSDLKTKMATLERELKQ-QRESTQAVEAKAQQLQEEGE-----RRAAAERQVQQLE 399
             L    +L+ +    ER L+Q + E  + V+   +  Q   E     +RA+   +  QLE
Sbjct: 1671 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1730

Query: 400  EQVQQLEAQVQLLVGRLEGAGQQVC-------WASTELDKEKARVDSMVRHQESLQAKQR 452
              +Q+    V  L    E   QQ          A  EL++ + + +  +R +  LQA++ 
Sbjct: 1731 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR--LQAEEV 1788

Query: 453  ALLKQLDSLDQEREELRGSLDEAEAQ---RARVEEQLQSEREQGQCQLRAQQELLQSLQR 509
            A  K L   + E+++     +EAE +   R + EEQ   +RE  + +L  Q++L +   +
Sbjct: 1789 AQQKSLAQAEAEKQK-----EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1843

Query: 510  EKQGLEQATTDLRLTIL--ELEREL--EELKERERLLVAFPDLHRPTETQIHGGRSSS-- 563
            ++   EQ    LR      E +R+L  EEL   +R   A     +  E ++   R+    
Sbjct: 1844 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1903

Query: 564  -VESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQ 614
             + S+     +S + ++  +++++A   R R L EE  RL+++  + +   Q
Sbjct: 1904 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1955



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 77/313 (24%), Positives = 144/313 (46%), Gaps = 49/313 (15%)

Query: 327  RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATL-ERELKQQRESTQAVEAKAQQLQEEG 385
            R+ EE+E+   +   ++++ L E      K   L E   + + ++ +  +   Q++QEE 
Sbjct: 1479 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1538

Query: 386  ERRAAA----ERQVQQLEEQVQQL----EAQVQLLVGRLEGAGQQVCWASTELDKEKARV 437
             RR  A    ++Q + ++E++QQL    EA++Q    + E A           ++ + R+
Sbjct: 1539 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA-----------ERSRLRI 1587

Query: 438  DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQ----G 493
            +  +R    ++ +  A  +Q    + E + LR   +EAEAQ+ + +E+ +  R Q     
Sbjct: 1588 EEEIR---VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1644

Query: 494  QCQLRAQQELLQSLQ------REKQGLEQATTDLRLTILELERELE--ELKERERLLVAF 545
            Q + +A+ EL   ++      REKQ   QA  +LRL   E ER L   E++   ++ VA 
Sbjct: 1645 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1704

Query: 546  PDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEE---NGRL 602
                R  E ++   R+S  E            T  +ER +Q   + +  L+EE     + 
Sbjct: 1705 ETAQRSAEAELQSKRASFAEK-----------TAQLERSLQEEHVAVAQLREEAERRAQQ 1753

Query: 603  QSMLSKIREVAQQ 615
            Q+   + RE A++
Sbjct: 1754 QAEAERAREEAER 1766



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 74/272 (27%), Positives = 127/272 (46%), Gaps = 13/272 (4%)

Query: 277  AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
            AE+R+ L  +   +E  R QL EA  Q     ++  K  Q   QE+  RR +A  D Q  
Sbjct: 1493 AEERERLAEVEAALEKQR-QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1551

Query: 337  SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEG--ERRAAAERQ 394
                 ++ Q L ++S+ + +    + E  ++       E +  +LQ E    +R  AE +
Sbjct: 1552 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1611

Query: 395  VQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQ-ESLQAKQRA 453
            +Q L  + ++ EAQ +      E   +QV   S    + +  + S V+ + E+ + KQRA
Sbjct: 1612 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1671

Query: 454  LLKQLDSLDQEREELRGSLDEAEAQRAR-VEEQLQSEREQGQCQLRAQQ----ELLQSLQ 508
            L + L+ L  + EE    L +AE +RAR V+  L++ +   + +L++++    E    L+
Sbjct: 1672 L-QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1730

Query: 509  REKQGLEQATTDLRLTILELERELEELKERER 540
            R  Q    A   LR    E ER  ++  E ER
Sbjct: 1731 RSLQEEHVAVAQLR---EEAERRAQQQAEAER 1759



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 73/287 (25%), Positives = 136/287 (47%), Gaps = 24/287 (8%)

Query: 276  AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKL-------EQALKQEQGARRRQ 328
            A E  +  +++ + + ++R Q+EE    K  +  +   L        Q   QE+  + +Q
Sbjct: 2353 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2412

Query: 329  AEEDEQCLSEWEHDKQQL--LTETSDLKTKMATLERELKQQRESTQA---VEAKAQQLQE 383
              E+   LS    +  +L  L E  DL  + A  E+ LK++ ++ Q    ++A+A+ LQ+
Sbjct: 2413 VAEEAARLSVAAQEAARLRQLAE-EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2471

Query: 384  EGERRAAAERQVQQLEEQV-QQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVR 442
            + E      R++Q+ +EQ+ QQL  + Q     LE   Q+    S E ++ K RV  M R
Sbjct: 2472 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2531

Query: 443  HQESLQAKQRALLKQLDSLDQE--REELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQ 500
             Q   +   +   KQ + + ++  R EL      A  ++  + + L+ +R+Q        
Sbjct: 2532 AQARAEEDAQRFRKQAEEIGEKLHRTEL------ATQEKVTLVQTLEIQRQQSDHDAERL 2585

Query: 501  QELLQSLQREKQGLEQATTDLRLTILELERELEE--LKERERLLVAF 545
            +E +  L+REK+ L+Q    L+L   E++   +E  L+E + L  +F
Sbjct: 2586 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2632



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 74/270 (27%), Positives = 124/270 (45%), Gaps = 23/270 (8%)

Query: 292  ALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGA---RRRQAEEDEQCLSEWEHDKQQLLT 348
            A R+   E + ++    ++  +LE++L++E  A    R +AE   Q  +E E  +++   
Sbjct: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1766

Query: 349  ETS--DLKTKMATLER----ELKQQRESTQA-VEAKAQQLQEEGERRAAAERQ-VQQLEE 400
            E     LK   A   R    E+ QQ+   QA  E + ++ + E  RR  AE Q V+Q E 
Sbjct: 1767 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1826

Query: 401  QVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDS 460
              Q+LE Q QL     EG  QQ   A  EL + +A  +   + ++ L+ +   L ++  +
Sbjct: 1827 AEQELEKQRQLA----EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1882

Query: 461  LDQEREELRGSLDEAEAQ-------RARVEEQLQSEREQGQCQLRAQQELLQSLQREKQG 513
              Q+R+EL   L +  A+       +AR EE+ +S  E+ + +L A+    + L  E   
Sbjct: 1883 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1942

Query: 514  LEQATTDL-RLTILELERELEELKERERLL 542
            L     +  R   L  E    +  E ER+L
Sbjct: 1943 LRALAEEAKRQRQLAEEDAARQRAEAERVL 1972



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 69/332 (20%), Positives = 152/332 (45%), Gaps = 26/332 (7%)

Query: 227  VQGSLQKVGKVVISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRL 286
            +Q   +K+ +V     +         + +QL ++ +  +   A  + +   +  ++ TRL
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462

Query: 287  SKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQL 346
                E L+ Q E A+ Q   L++   ++ Q L +E    +R  E + Q        + ++
Sbjct: 2463 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ-------RQLEM 2515

Query: 347  LTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQ----VQQLEEQV 402
              E   LK ++A + R   +  E  Q    +A+++ E+  R   A ++    VQ LE Q 
Sbjct: 2516 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2575

Query: 403  QQLEAQVQLL---VGRLEGAGQQVCWASTELDKEKARVDSMVRHQ--ESLQAKQRALLKQ 457
            QQ +   + L   +  LE   +++   +  L  +   + ++ + Q  +  QA Q++ L +
Sbjct: 2576 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2635

Query: 458  LDSL-------DQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQRE 510
             DSL       +QE+ +L     +  A+  ++ E+ Q +++Q +   + +Q L+ S++  
Sbjct: 2636 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEA 2692

Query: 511  KQGLEQATTDLRLTILELERELEELKERERLL 542
            ++   +A   +R    EL++  ++ +++E LL
Sbjct: 2693 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2724



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 105/401 (26%), Positives = 180/401 (44%), Gaps = 48/401 (11%)

Query: 270  ATVGRWAAEQRKDLTRLS-KHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRR- 327
            A   R   E  ++L R   K  EALR +L+  E  +     QA   +Q  + E+ ARRR 
Sbjct: 1755 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1814

Query: 328  QAEED---EQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEE 384
            +AEE    ++ L+E E +KQ+ L E +  +   A  E+EL + R  T+  E + Q L+EE
Sbjct: 1815 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA--EQELIRLRAETEQGEQQRQLLEEE 1872

Query: 385  GER----RAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTE----LDKEKAR 436
              R     AAA ++ Q+LE ++ ++ A++++L+     A ++    S +    L+ E  R
Sbjct: 1873 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1932

Query: 437  VDSMVRHQESL-----QAKQRALLKQLDSLDQEREELRGSLDE----AEAQRARVEEQL- 486
               +      L     +AK++  L + D+  Q  E  R   ++     EA R + E ++ 
Sbjct: 1933 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1992

Query: 487  --QSEREQGQCQLRAQQELLQSLQREKQGLE-QATTDLRLTIL------ELEREL----E 533
              + E E  + +  A+ E  Q  + E+Q  + +A  + RL  L      ELER+     +
Sbjct: 1993 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 2052

Query: 534  ELKER----ERLLVAFPDLHR----PTETQIHGGRSSSVESQITCPTDSGNVTDHMERQV 585
             L++R    E +L       +      E ++  GR  S         +   +    +RQ+
Sbjct: 2053 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2112

Query: 586  QANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIPQDRL 626
             A + R R  +E   R+Q  L+   E A+Q    L   +RL
Sbjct: 2113 AAEEERRR--REAEERVQKSLAAEEEAARQRKAALEEVERL 2151



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 58/202 (28%), Positives = 99/202 (49%), Gaps = 17/202 (8%)

Query: 291  EALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTET 350
            E LR  + E E +K+ L+++A  L+  LK E+     Q  + EQ L E +  +Q  L+E 
Sbjct: 2583 ERLREAIAELEREKEKLQQEAKLLQ--LKSEE----MQTVQQEQLLQETQALQQSFLSEK 2636

Query: 351  SDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQ 410
              L  +   +E+E  +  +  Q   AKAQQL+EE       +RQ QQ+E++ Q+L A ++
Sbjct: 2637 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE------QQRQQQQMEQERQRLVASME 2690

Query: 411  LLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ-RALLKQLDSLDQEREELR 469
                R   A + V     EL     +++   R QE L A++ + L +QL  L+++     
Sbjct: 2691 EARRRQHEAEEGVRRKQEELQ----QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2746

Query: 470  GSLDEAEAQRARVEEQLQSERE 491
               +E  A +    + L + R+
Sbjct: 2747 AHSEEVTASQVAATKTLPNGRD 2768



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 64/364 (17%), Positives = 163/364 (44%), Gaps = 36/364 (9%)

Query: 269  AATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGAR--R 326
            A  +G W  + R    R  + ++A+   L +++  ++ LR++   LE+  +  +     +
Sbjct: 1353 ADPLGAWLQDAR----RRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1406

Query: 327  RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGE 386
            R A++    + ++E    QL+T  + L+  +A+  ++ K Q  S   ++          E
Sbjct: 1407 RFAKQYINAIKDYE---LQLVTYKAQLEP-VASPAKKPKVQSGSESVIQEYVDLRTHYSE 1462

Query: 387  RRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQES 446
                  + ++ + E ++++E + +L   +     +++      L+K++   ++  + +  
Sbjct: 1463 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ 1522

Query: 447  LQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQS 506
             + + + L +++      REE   +  +A+ Q+  ++E+LQ  R+  + +++A+    ++
Sbjct: 1523 AEREAKELQQRMQEEVVRREE---AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1579

Query: 507  LQREKQGLEQATTDLRLTILELER-------ELEELKERERLLVA--------FPDLHRP 551
             +R +  +E+    +RL +   ER       EL+ L+ R     A           L R 
Sbjct: 1580 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1639

Query: 552  TETQIHGGRSSSVE--SQITCPTDSGNVTDHMERQVQA-NDIRIRVLQEENGRLQSMLSK 608
             + +    R + VE  S++    ++       +R +QA  ++R++  + E    Q+ + +
Sbjct: 1640 VQDESQRKRQAEVELASRVKAEAEAAR---EKQRALQALEELRLQAEEAERRLRQAEVER 1696

Query: 609  IREV 612
             R+V
Sbjct: 1697 ARQV 1700



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 72/308 (23%), Positives = 126/308 (40%), Gaps = 56/308 (18%)

Query: 282  DLTRLSKHVEALRAQLEEAEGQKDGLRKQ---AGKLEQALKQEQGAR----RRQAEEDEQ 334
            +L      ++ LRAQ E  +   D LR +   A ++ + L+Q  G R     R  E   Q
Sbjct: 1261 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1320

Query: 335  CLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGER-RAAAER 393
             L  W    Q +L +T   + ++  L R+L+  RES   + A  Q  +   E+ +A    
Sbjct: 1321 LLERW----QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1376

Query: 394  QVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQ----- 448
              Q + EQ++Q +A ++ +    E   +   +A   ++  K     +V ++  L+     
Sbjct: 1377 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1436

Query: 449  AKQRALLKQLDSLDQEREELRGSLDE-------------------------AEAQRARVE 483
            AK+  +    +S+ QE  +LR    E                         AE QRA   
Sbjct: 1437 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1496

Query: 484  EQL---------QSEREQGQCQLRAQ-----QELLQSLQREKQGLEQATTDLRLTILELE 529
            E+L         Q +  +   Q +AQ     +EL Q +Q E    E+A  D +     ++
Sbjct: 1497 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556

Query: 530  RELEELKE 537
             EL++L++
Sbjct: 1557 EELQQLRQ 1564



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 75/305 (24%), Positives = 137/305 (44%), Gaps = 32/305 (10%)

Query: 250  SLGQFQQLVQDSMGLRPLPAATVGRWAAE-QRKDLTRLSKHVEALRAQLEEAEG--QKDG 306
            SL  +Q L +D   +R    AT      E QR+ L  L  H +A     ++A G   +D 
Sbjct: 1029 SLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR 1088

Query: 307  L--RKQAGKLEQALKQEQGARRRQAEED---EQCLSEWEHDKQQL-LTETSDLKTKMATL 360
            L   ++ G      +Q   +  + A+E+   ++C+SE +  + QL   ET  +      L
Sbjct: 1089 LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 1148

Query: 361  E----RELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQ---VQQLEAQVQLLV 413
            +    RE  Q+    Q  +A+ + L +   R +A   +V  L E       L ++++L +
Sbjct: 1149 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1208

Query: 414  GRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLD 473
            G+LE   Q    ++  L+K K  +  ++R  +  +   RA  +QL    +E + +  +L 
Sbjct: 1209 GKLE---QVRSLSAIYLEKLKT-ISLVIRGTQGAEEVLRAHEEQL----KEAQAVPATLP 1260

Query: 474  EAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELE 533
            E EA +A +++         + Q  AQQ    +L+ E +G ++    L+    E + E+E
Sbjct: 1261 ELEATKASLKKL--------RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1312

Query: 534  ELKER 538
              +ER
Sbjct: 1313 RWRER 1317



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 44/141 (31%), Positives = 65/141 (46%), Gaps = 13/141 (9%)

Query: 396  QQLEEQVQQLEAQVQLLVGRLE----GAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ 451
            Q+ +E V +LEAQ Q LV             + W S   D +  R  S+   +     +Q
Sbjct: 1000 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 1059

Query: 452  RALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQ--- 508
            R  L  L+   Q    LR S D   A     E++L +ERE G C    QQ LLQSL+   
Sbjct: 1060 RQALHSLELHYQAF--LRDSQD---AGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGA 1113

Query: 509  REKQGLEQATTDLRLTILELE 529
            +E+   ++  ++L+   L+LE
Sbjct: 1114 QEESRCQRCISELKDIRLQLE 1134



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 30/158 (18%), Positives = 67/158 (42%), Gaps = 5/158 (3%)

Query: 253  QFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAG 312
            + +QL QD +           R   +  ++  RL   +E  R +  EAE      +++  
Sbjct: 2652 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2711

Query: 313  KLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQ 372
            +LEQ  +Q++     + +   + L   E   +  L  + ++        + L   R++  
Sbjct: 2712 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2771

Query: 373  AVEAKAQ-QLQEEGERRAAAERQVQQL----EEQVQQL 405
               A+A+ +   +G RR  + +++Q+      E++Q+L
Sbjct: 2772 GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2809


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 95/413 (23%), Positives = 180/413 (43%), Gaps = 44/413 (10%)

Query: 225  ASVQGSLQKVGKVVISLCQSQN--LPSSLGQFQQLVQDSMGLRP-LPAATVGRWAAEQRK 281
            A ++  L ++ K   S  + Q   +  +L Q +Q+ ++ + L+     A  G+  AE   
Sbjct: 1867 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELEL 1924

Query: 282  DLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQ----CLS 337
            +L R+  + E      E+AE        +A +  Q L  E+  RRR+AEE  Q       
Sbjct: 1925 ELGRIRSNAEDTLRSKEQAE-------LEAARQRQ-LAAEEERRRREAEERVQKSLAAEE 1976

Query: 338  EWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQL-QEEGERRAAAERQ-- 394
            E    ++  L E   LK K+     E ++ RE  +   A+  QL QE  ++R  AE +  
Sbjct: 1977 EAARQRKAALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2032

Query: 395  ---VQQLEEQVQQLEAQVQLLVGRLEG-------AGQQVCWASTELDKEKARVDSMVRHQ 444
               VQQ E+++QQ   Q Q ++ +L G       A ++   A  + ++E A+    V   
Sbjct: 2033 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2092

Query: 445  ESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELL 504
            E L+       +         E+LR   ++  A+RA+ E+    +++    ++   ++  
Sbjct: 2093 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2152

Query: 505  QSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSV 564
            +   R+K  +EQ  T LRL + E + +   L E  + L A        E      + S V
Sbjct: 2153 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA--------EATEAARQRSQV 2204

Query: 565  ESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGR--LQSMLSKIREVAQQ 615
            E ++            ++ +++A +  + +  ++N +  LQ    K+++VA++
Sbjct: 2205 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2257



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 94/412 (22%), Positives = 178/412 (43%), Gaps = 47/412 (11%)

Query: 243  QSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEG 302
            Q +++   L Q +Q  +  +  +   A    R      +++  +   +EA   Q   AEG
Sbjct: 1392 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1451

Query: 303  QKDGLRKQAGKLEQALKQ--EQGARRRQAEEDE---------------QCLSEWEHDKQQ 345
            +   LR +A + E   +Q  E+  R R+  +DE               +  +E   +KQ+
Sbjct: 1452 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1511

Query: 346  LLTETSDLKTKMATLERELKQ-QRESTQAVEAKAQQLQEEGE-----RRAAAERQVQQLE 399
             L    +L+ +    ER L+Q + E  + V+   +  Q   E     +RA+   +  QLE
Sbjct: 1512 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1571

Query: 400  EQVQQLEAQVQLLVGRLEGAGQQVC-------WASTELDKEKARVDSMVRHQESLQAKQR 452
              +Q+    V  L    E   QQ          A  EL++ + + +  +R +  LQA++ 
Sbjct: 1572 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR--LQAEEV 1629

Query: 453  ALLKQLDSLDQEREELRGSLDEAEAQ---RARVEEQLQSEREQGQCQLRAQQELLQSLQR 509
            A  K L   + E+++     +EAE +   R + EEQ   +RE  + +L  Q++L +   +
Sbjct: 1630 AQQKSLAQAEAEKQK-----EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1684

Query: 510  EKQGLEQATTDLRLTIL--ELEREL--EELKERERLLVAFPDLHRPTETQIHGGRSSS-- 563
            ++   EQ    LR      E +R+L  EEL   +R   A     +  E ++   R+    
Sbjct: 1685 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1744

Query: 564  -VESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQ 614
             + S+     +S + ++  +++++A   R R L EE  RL+++  + +   Q
Sbjct: 1745 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1796



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 77/313 (24%), Positives = 144/313 (46%), Gaps = 49/313 (15%)

Query: 327  RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATL-ERELKQQRESTQAVEAKAQQLQEEG 385
            R+ EE+E+   +   ++++ L E      K   L E   + + ++ +  +   Q++QEE 
Sbjct: 1320 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1379

Query: 386  ERRAAA----ERQVQQLEEQVQQL----EAQVQLLVGRLEGAGQQVCWASTELDKEKARV 437
             RR  A    ++Q + ++E++QQL    EA++Q    + E A           ++ + R+
Sbjct: 1380 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA-----------ERSRLRI 1428

Query: 438  DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQ----G 493
            +  +R    ++ +  A  +Q    + E + LR   +EAEAQ+ + +E+ +  R Q     
Sbjct: 1429 EEEIR---VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1485

Query: 494  QCQLRAQQELLQSLQ------REKQGLEQATTDLRLTILELERELE--ELKERERLLVAF 545
            Q + +A+ EL   ++      REKQ   QA  +LRL   E ER L   E++   ++ VA 
Sbjct: 1486 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1545

Query: 546  PDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEE---NGRL 602
                R  E ++   R+S  E            T  +ER +Q   + +  L+EE     + 
Sbjct: 1546 ETAQRSAEAELQSKRASFAEK-----------TAQLERSLQEEHVAVAQLREEAERRAQQ 1594

Query: 603  QSMLSKIREVAQQ 615
            Q+   + RE A++
Sbjct: 1595 QAEAERAREEAER 1607



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 74/272 (27%), Positives = 127/272 (46%), Gaps = 13/272 (4%)

Query: 277  AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
            AE+R+ L  +   +E  R QL EA  Q     ++  K  Q   QE+  RR +A  D Q  
Sbjct: 1334 AEERERLAEVEAALEKQR-QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1392

Query: 337  SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEG--ERRAAAERQ 394
                 ++ Q L ++S+ + +    + E  ++       E +  +LQ E    +R  AE +
Sbjct: 1393 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1452

Query: 395  VQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQ-ESLQAKQRA 453
            +Q L  + ++ EAQ +      E   +QV   S    + +  + S V+ + E+ + KQRA
Sbjct: 1453 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1512

Query: 454  LLKQLDSLDQEREELRGSLDEAEAQRAR-VEEQLQSEREQGQCQLRAQQ----ELLQSLQ 508
            L + L+ L  + EE    L +AE +RAR V+  L++ +   + +L++++    E    L+
Sbjct: 1513 L-QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1571

Query: 509  REKQGLEQATTDLRLTILELERELEELKERER 540
            R  Q    A   LR    E ER  ++  E ER
Sbjct: 1572 RSLQEEHVAVAQLR---EEAERRAQQQAEAER 1600



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 73/287 (25%), Positives = 136/287 (47%), Gaps = 24/287 (8%)

Query: 276  AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKL-------EQALKQEQGARRRQ 328
            A E  +  +++ + + ++R Q+EE    K  +  +   L        Q   QE+  + +Q
Sbjct: 2194 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2253

Query: 329  AEEDEQCLSEWEHDKQQL--LTETSDLKTKMATLERELKQQRESTQA---VEAKAQQLQE 383
              E+   LS    +  +L  L E  DL  + A  E+ LK++ ++ Q    ++A+A+ LQ+
Sbjct: 2254 VAEEAARLSVAAQEAARLRQLAE-EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2312

Query: 384  EGERRAAAERQVQQLEEQV-QQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVR 442
            + E      R++Q+ +EQ+ QQL  + Q     LE   Q+    S E ++ K RV  M R
Sbjct: 2313 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2372

Query: 443  HQESLQAKQRALLKQLDSLDQE--REELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQ 500
             Q   +   +   KQ + + ++  R EL      A  ++  + + L+ +R+Q        
Sbjct: 2373 AQARAEEDAQRFRKQAEEIGEKLHRTEL------ATQEKVTLVQTLEIQRQQSDHDAERL 2426

Query: 501  QELLQSLQREKQGLEQATTDLRLTILELERELEE--LKERERLLVAF 545
            +E +  L+REK+ L+Q    L+L   E++   +E  L+E + L  +F
Sbjct: 2427 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2473



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 74/270 (27%), Positives = 124/270 (45%), Gaps = 23/270 (8%)

Query: 292  ALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGA---RRRQAEEDEQCLSEWEHDKQQLLT 348
            A R+   E + ++    ++  +LE++L++E  A    R +AE   Q  +E E  +++   
Sbjct: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1607

Query: 349  ETS--DLKTKMATLER----ELKQQRESTQA-VEAKAQQLQEEGERRAAAERQ-VQQLEE 400
            E     LK   A   R    E+ QQ+   QA  E + ++ + E  RR  AE Q V+Q E 
Sbjct: 1608 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1667

Query: 401  QVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDS 460
              Q+LE Q QL     EG  QQ   A  EL + +A  +   + ++ L+ +   L ++  +
Sbjct: 1668 AEQELEKQRQLA----EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1723

Query: 461  LDQEREELRGSLDEAEAQ-------RARVEEQLQSEREQGQCQLRAQQELLQSLQREKQG 513
              Q+R+EL   L +  A+       +AR EE+ +S  E+ + +L A+    + L  E   
Sbjct: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1783

Query: 514  LEQATTDL-RLTILELERELEELKERERLL 542
            L     +  R   L  E    +  E ER+L
Sbjct: 1784 LRALAEEAKRQRQLAEEDAARQRAEAERVL 1813



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 69/332 (20%), Positives = 152/332 (45%), Gaps = 26/332 (7%)

Query: 227  VQGSLQKVGKVVISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRL 286
            +Q   +K+ +V     +         + +QL ++ +  +   A  + +   +  ++ TRL
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303

Query: 287  SKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQL 346
                E L+ Q E A+ Q   L++   ++ Q L +E    +R  E + Q        + ++
Sbjct: 2304 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ-------RQLEM 2356

Query: 347  LTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQ----VQQLEEQV 402
              E   LK ++A + R   +  E  Q    +A+++ E+  R   A ++    VQ LE Q 
Sbjct: 2357 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2416

Query: 403  QQLEAQVQLL---VGRLEGAGQQVCWASTELDKEKARVDSMVRHQ--ESLQAKQRALLKQ 457
            QQ +   + L   +  LE   +++   +  L  +   + ++ + Q  +  QA Q++ L +
Sbjct: 2417 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2476

Query: 458  LDSL-------DQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQRE 510
             DSL       +QE+ +L     +  A+  ++ E+ Q +++Q +   + +Q L+ S++  
Sbjct: 2477 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEA 2533

Query: 511  KQGLEQATTDLRLTILELERELEELKERERLL 542
            ++   +A   +R    EL++  ++ +++E LL
Sbjct: 2534 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2565



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 105/401 (26%), Positives = 180/401 (44%), Gaps = 48/401 (11%)

Query: 270  ATVGRWAAEQRKDLTRLS-KHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRR- 327
            A   R   E  ++L R   K  EALR +L+  E  +     QA   +Q  + E+ ARRR 
Sbjct: 1596 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1655

Query: 328  QAEED---EQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEE 384
            +AEE    ++ L+E E +KQ+ L E +  +   A  E+EL + R  T+  E + Q L+EE
Sbjct: 1656 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA--EQELIRLRAETEQGEQQRQLLEEE 1713

Query: 385  GER----RAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTE----LDKEKAR 436
              R     AAA ++ Q+LE ++ ++ A++++L+     A ++    S +    L+ E  R
Sbjct: 1714 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1773

Query: 437  VDSMVRHQESL-----QAKQRALLKQLDSLDQEREELRGSLDE----AEAQRARVEEQL- 486
               +      L     +AK++  L + D+  Q  E  R   ++     EA R + E ++ 
Sbjct: 1774 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1833

Query: 487  --QSEREQGQCQLRAQQELLQSLQREKQGLE-QATTDLRLTIL------ELEREL----E 533
              + E E  + +  A+ E  Q  + E+Q  + +A  + RL  L      ELER+     +
Sbjct: 1834 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1893

Query: 534  ELKER----ERLLVAFPDLHR----PTETQIHGGRSSSVESQITCPTDSGNVTDHMERQV 585
             L++R    E +L       +      E ++  GR  S         +   +    +RQ+
Sbjct: 1894 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1953

Query: 586  QANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIPQDRL 626
             A + R R  +E   R+Q  L+   E A+Q    L   +RL
Sbjct: 1954 AAEEERRR--REAEERVQKSLAAEEEAARQRKAALEEVERL 1992



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 58/202 (28%), Positives = 99/202 (49%), Gaps = 17/202 (8%)

Query: 291  EALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTET 350
            E LR  + E E +K+ L+++A  L+  LK E+     Q  + EQ L E +  +Q  L+E 
Sbjct: 2424 ERLREAIAELEREKEKLQQEAKLLQ--LKSEE----MQTVQQEQLLQETQALQQSFLSEK 2477

Query: 351  SDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQ 410
              L  +   +E+E  +  +  Q   AKAQQL+EE       +RQ QQ+E++ Q+L A ++
Sbjct: 2478 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE------QQRQQQQMEQERQRLVASME 2531

Query: 411  LLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ-RALLKQLDSLDQEREELR 469
                R   A + V     EL     +++   R QE L A++ + L +QL  L+++     
Sbjct: 2532 EARRRQHEAEEGVRRKQEELQ----QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2587

Query: 470  GSLDEAEAQRARVEEQLQSERE 491
               +E  A +    + L + R+
Sbjct: 2588 AHSEEVTASQVAATKTLPNGRD 2609



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 64/364 (17%), Positives = 163/364 (44%), Gaps = 36/364 (9%)

Query: 269  AATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGAR--R 326
            A  +G W  + R    R  + ++A+   L +++  ++ LR++   LE+  +  +     +
Sbjct: 1194 ADPLGAWLQDAR----RRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1247

Query: 327  RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGE 386
            R A++    + ++E    QL+T  + L+  +A+  ++ K Q  S   ++          E
Sbjct: 1248 RFAKQYINAIKDYE---LQLVTYKAQLEP-VASPAKKPKVQSGSESVIQEYVDLRTHYSE 1303

Query: 387  RRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQES 446
                  + ++ + E ++++E + +L   +     +++      L+K++   ++  + +  
Sbjct: 1304 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ 1363

Query: 447  LQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQS 506
             + + + L +++      REE   +  +A+ Q+  ++E+LQ  R+  + +++A+    ++
Sbjct: 1364 AEREAKELQQRMQEEVVRREE---AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1420

Query: 507  LQREKQGLEQATTDLRLTILELER-------ELEELKERERLLVA--------FPDLHRP 551
             +R +  +E+    +RL +   ER       EL+ L+ R     A           L R 
Sbjct: 1421 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1480

Query: 552  TETQIHGGRSSSVE--SQITCPTDSGNVTDHMERQVQA-NDIRIRVLQEENGRLQSMLSK 608
             + +    R + VE  S++    ++       +R +QA  ++R++  + E    Q+ + +
Sbjct: 1481 VQDESQRKRQAEVELASRVKAEAEAAR---EKQRALQALEELRLQAEEAERRLRQAEVER 1537

Query: 609  IREV 612
             R+V
Sbjct: 1538 ARQV 1541



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 72/308 (23%), Positives = 126/308 (40%), Gaps = 56/308 (18%)

Query: 282  DLTRLSKHVEALRAQLEEAEGQKDGLRKQ---AGKLEQALKQEQGAR----RRQAEEDEQ 334
            +L      ++ LRAQ E  +   D LR +   A ++ + L+Q  G R     R  E   Q
Sbjct: 1102 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1161

Query: 335  CLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGER-RAAAER 393
             L  W    Q +L +T   + ++  L R+L+  RES   + A  Q  +   E+ +A    
Sbjct: 1162 LLERW----QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1217

Query: 394  QVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQ----- 448
              Q + EQ++Q +A ++ +    E   +   +A   ++  K     +V ++  L+     
Sbjct: 1218 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1277

Query: 449  AKQRALLKQLDSLDQEREELRGSLDE-------------------------AEAQRARVE 483
            AK+  +    +S+ QE  +LR    E                         AE QRA   
Sbjct: 1278 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1337

Query: 484  EQL---------QSEREQGQCQLRAQ-----QELLQSLQREKQGLEQATTDLRLTILELE 529
            E+L         Q +  +   Q +AQ     +EL Q +Q E    E+A  D +     ++
Sbjct: 1338 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1397

Query: 530  RELEELKE 537
             EL++L++
Sbjct: 1398 EELQQLRQ 1405



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 75/305 (24%), Positives = 137/305 (44%), Gaps = 32/305 (10%)

Query: 250  SLGQFQQLVQDSMGLRPLPAATVGRWAAE-QRKDLTRLSKHVEALRAQLEEAEG--QKDG 306
            SL  +Q L +D   +R    AT      E QR+ L  L  H +A     ++A G   +D 
Sbjct: 870  SLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR 929

Query: 307  L--RKQAGKLEQALKQEQGARRRQAEED---EQCLSEWEHDKQQL-LTETSDLKTKMATL 360
            L   ++ G      +Q   +  + A+E+   ++C+SE +  + QL   ET  +      L
Sbjct: 930  LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 989

Query: 361  E----RELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQ---VQQLEAQVQLLV 413
            +    RE  Q+    Q  +A+ + L +   R +A   +V  L E       L ++++L +
Sbjct: 990  DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1049

Query: 414  GRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLD 473
            G+LE   Q    ++  L+K K  +  ++R  +  +   RA  +QL    +E + +  +L 
Sbjct: 1050 GKLE---QVRSLSAIYLEKLKT-ISLVIRGTQGAEEVLRAHEEQL----KEAQAVPATLP 1101

Query: 474  EAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELE 533
            E EA +A +++         + Q  AQQ    +L+ E +G ++    L+    E + E+E
Sbjct: 1102 ELEATKASLKKL--------RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1153

Query: 534  ELKER 538
              +ER
Sbjct: 1154 RWRER 1158



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 44/141 (31%), Positives = 65/141 (46%), Gaps = 13/141 (9%)

Query: 396 QQLEEQVQQLEAQVQLLVGRLE----GAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ 451
           Q+ +E V +LEAQ Q LV             + W S   D +  R  S+   +     +Q
Sbjct: 841 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 900

Query: 452 RALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQ--- 508
           R  L  L+   Q    LR S D   A     E++L +ERE G C    QQ LLQSL+   
Sbjct: 901 RQALHSLELHYQAF--LRDSQD---AGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGA 954

Query: 509 REKQGLEQATTDLRLTILELE 529
           +E+   ++  ++L+   L+LE
Sbjct: 955 QEESRCQRCISELKDIRLQLE 975



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 30/158 (18%), Positives = 67/158 (42%), Gaps = 5/158 (3%)

Query: 253  QFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAG 312
            + +QL QD +           R   +  ++  RL   +E  R +  EAE      +++  
Sbjct: 2493 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2552

Query: 313  KLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQ 372
            +LEQ  +Q++     + +   + L   E   +  L  + ++        + L   R++  
Sbjct: 2553 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2612

Query: 373  AVEAKAQ-QLQEEGERRAAAERQVQQL----EEQVQQL 405
               A+A+ +   +G RR  + +++Q+      E++Q+L
Sbjct: 2613 GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2650


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 95/413 (23%), Positives = 180/413 (43%), Gaps = 44/413 (10%)

Query: 225  ASVQGSLQKVGKVVISLCQSQN--LPSSLGQFQQLVQDSMGLRP-LPAATVGRWAAEQRK 281
            A ++  L ++ K   S  + Q   +  +L Q +Q+ ++ + L+     A  G+  AE   
Sbjct: 1875 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELEL 1932

Query: 282  DLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQ----CLS 337
            +L R+  + E      E+AE        +A +  Q L  E+  RRR+AEE  Q       
Sbjct: 1933 ELGRIRSNAEDTLRSKEQAE-------LEAARQRQ-LAAEEERRRREAEERVQKSLAAEE 1984

Query: 338  EWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQL-QEEGERRAAAERQ-- 394
            E    ++  L E   LK K+     E ++ RE  +   A+  QL QE  ++R  AE +  
Sbjct: 1985 EAARQRKAALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2040

Query: 395  ---VQQLEEQVQQLEAQVQLLVGRLEG-------AGQQVCWASTELDKEKARVDSMVRHQ 444
               VQQ E+++QQ   Q Q ++ +L G       A ++   A  + ++E A+    V   
Sbjct: 2041 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2100

Query: 445  ESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELL 504
            E L+       +         E+LR   ++  A+RA+ E+    +++    ++   ++  
Sbjct: 2101 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2160

Query: 505  QSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSV 564
            +   R+K  +EQ  T LRL + E + +   L E  + L A        E      + S V
Sbjct: 2161 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA--------EATEAARQRSQV 2212

Query: 565  ESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGR--LQSMLSKIREVAQQ 615
            E ++            ++ +++A +  + +  ++N +  LQ    K+++VA++
Sbjct: 2213 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2265



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 94/412 (22%), Positives = 178/412 (43%), Gaps = 47/412 (11%)

Query: 243  QSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEG 302
            Q +++   L Q +Q  +  +  +   A    R      +++  +   +EA   Q   AEG
Sbjct: 1400 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1459

Query: 303  QKDGLRKQAGKLEQALKQ--EQGARRRQAEEDE---------------QCLSEWEHDKQQ 345
            +   LR +A + E   +Q  E+  R R+  +DE               +  +E   +KQ+
Sbjct: 1460 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1519

Query: 346  LLTETSDLKTKMATLERELKQ-QRESTQAVEAKAQQLQEEGE-----RRAAAERQVQQLE 399
             L    +L+ +    ER L+Q + E  + V+   +  Q   E     +RA+   +  QLE
Sbjct: 1520 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1579

Query: 400  EQVQQLEAQVQLLVGRLEGAGQQVC-------WASTELDKEKARVDSMVRHQESLQAKQR 452
              +Q+    V  L    E   QQ          A  EL++ + + +  +R +  LQA++ 
Sbjct: 1580 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR--LQAEEV 1637

Query: 453  ALLKQLDSLDQEREELRGSLDEAEAQ---RARVEEQLQSEREQGQCQLRAQQELLQSLQR 509
            A  K L   + E+++     +EAE +   R + EEQ   +RE  + +L  Q++L +   +
Sbjct: 1638 AQQKSLAQAEAEKQK-----EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1692

Query: 510  EKQGLEQATTDLRLTIL--ELEREL--EELKERERLLVAFPDLHRPTETQIHGGRSSS-- 563
            ++   EQ    LR      E +R+L  EEL   +R   A     +  E ++   R+    
Sbjct: 1693 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1752

Query: 564  -VESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQ 614
             + S+     +S + ++  +++++A   R R L EE  RL+++  + +   Q
Sbjct: 1753 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1804



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 77/313 (24%), Positives = 144/313 (46%), Gaps = 49/313 (15%)

Query: 327  RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATL-ERELKQQRESTQAVEAKAQQLQEEG 385
            R+ EE+E+   +   ++++ L E      K   L E   + + ++ +  +   Q++QEE 
Sbjct: 1328 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1387

Query: 386  ERRAAA----ERQVQQLEEQVQQL----EAQVQLLVGRLEGAGQQVCWASTELDKEKARV 437
             RR  A    ++Q + ++E++QQL    EA++Q    + E A           ++ + R+
Sbjct: 1388 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA-----------ERSRLRI 1436

Query: 438  DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQ----G 493
            +  +R    ++ +  A  +Q    + E + LR   +EAEAQ+ + +E+ +  R Q     
Sbjct: 1437 EEEIR---VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1493

Query: 494  QCQLRAQQELLQSLQ------REKQGLEQATTDLRLTILELERELE--ELKERERLLVAF 545
            Q + +A+ EL   ++      REKQ   QA  +LRL   E ER L   E++   ++ VA 
Sbjct: 1494 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1553

Query: 546  PDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEE---NGRL 602
                R  E ++   R+S  E            T  +ER +Q   + +  L+EE     + 
Sbjct: 1554 ETAQRSAEAELQSKRASFAEK-----------TAQLERSLQEEHVAVAQLREEAERRAQQ 1602

Query: 603  QSMLSKIREVAQQ 615
            Q+   + RE A++
Sbjct: 1603 QAEAERAREEAER 1615



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 74/272 (27%), Positives = 127/272 (46%), Gaps = 13/272 (4%)

Query: 277  AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
            AE+R+ L  +   +E  R QL EA  Q     ++  K  Q   QE+  RR +A  D Q  
Sbjct: 1342 AEERERLAEVEAALEKQR-QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1400

Query: 337  SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEG--ERRAAAERQ 394
                 ++ Q L ++S+ + +    + E  ++       E +  +LQ E    +R  AE +
Sbjct: 1401 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1460

Query: 395  VQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQ-ESLQAKQRA 453
            +Q L  + ++ EAQ +      E   +QV   S    + +  + S V+ + E+ + KQRA
Sbjct: 1461 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1520

Query: 454  LLKQLDSLDQEREELRGSLDEAEAQRAR-VEEQLQSEREQGQCQLRAQQ----ELLQSLQ 508
            L + L+ L  + EE    L +AE +RAR V+  L++ +   + +L++++    E    L+
Sbjct: 1521 L-QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1579

Query: 509  REKQGLEQATTDLRLTILELERELEELKERER 540
            R  Q    A   LR    E ER  ++  E ER
Sbjct: 1580 RSLQEEHVAVAQLR---EEAERRAQQQAEAER 1608



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 73/287 (25%), Positives = 136/287 (47%), Gaps = 24/287 (8%)

Query: 276  AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKL-------EQALKQEQGARRRQ 328
            A E  +  +++ + + ++R Q+EE    K  +  +   L        Q   QE+  + +Q
Sbjct: 2202 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2261

Query: 329  AEEDEQCLSEWEHDKQQL--LTETSDLKTKMATLERELKQQRESTQA---VEAKAQQLQE 383
              E+   LS    +  +L  L E  DL  + A  E+ LK++ ++ Q    ++A+A+ LQ+
Sbjct: 2262 VAEEAARLSVAAQEAARLRQLAE-EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2320

Query: 384  EGERRAAAERQVQQLEEQV-QQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVR 442
            + E      R++Q+ +EQ+ QQL  + Q     LE   Q+    S E ++ K RV  M R
Sbjct: 2321 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2380

Query: 443  HQESLQAKQRALLKQLDSLDQE--REELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQ 500
             Q   +   +   KQ + + ++  R EL      A  ++  + + L+ +R+Q        
Sbjct: 2381 AQARAEEDAQRFRKQAEEIGEKLHRTEL------ATQEKVTLVQTLEIQRQQSDHDAERL 2434

Query: 501  QELLQSLQREKQGLEQATTDLRLTILELERELEE--LKERERLLVAF 545
            +E +  L+REK+ L+Q    L+L   E++   +E  L+E + L  +F
Sbjct: 2435 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2481



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 74/270 (27%), Positives = 124/270 (45%), Gaps = 23/270 (8%)

Query: 292  ALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGA---RRRQAEEDEQCLSEWEHDKQQLLT 348
            A R+   E + ++    ++  +LE++L++E  A    R +AE   Q  +E E  +++   
Sbjct: 1556 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1615

Query: 349  ETS--DLKTKMATLER----ELKQQRESTQA-VEAKAQQLQEEGERRAAAERQ-VQQLEE 400
            E     LK   A   R    E+ QQ+   QA  E + ++ + E  RR  AE Q V+Q E 
Sbjct: 1616 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1675

Query: 401  QVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDS 460
              Q+LE Q QL     EG  QQ   A  EL + +A  +   + ++ L+ +   L ++  +
Sbjct: 1676 AEQELEKQRQLA----EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1731

Query: 461  LDQEREELRGSLDEAEAQ-------RARVEEQLQSEREQGQCQLRAQQELLQSLQREKQG 513
              Q+R+EL   L +  A+       +AR EE+ +S  E+ + +L A+    + L  E   
Sbjct: 1732 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1791

Query: 514  LEQATTDL-RLTILELERELEELKERERLL 542
            L     +  R   L  E    +  E ER+L
Sbjct: 1792 LRALAEEAKRQRQLAEEDAARQRAEAERVL 1821



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 69/332 (20%), Positives = 152/332 (45%), Gaps = 26/332 (7%)

Query: 227  VQGSLQKVGKVVISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRL 286
            +Q   +K+ +V     +         + +QL ++ +  +   A  + +   +  ++ TRL
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311

Query: 287  SKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQL 346
                E L+ Q E A+ Q   L++   ++ Q L +E    +R  E + Q        + ++
Sbjct: 2312 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ-------RQLEM 2364

Query: 347  LTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQ----VQQLEEQV 402
              E   LK ++A + R   +  E  Q    +A+++ E+  R   A ++    VQ LE Q 
Sbjct: 2365 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2424

Query: 403  QQLEAQVQLL---VGRLEGAGQQVCWASTELDKEKARVDSMVRHQ--ESLQAKQRALLKQ 457
            QQ +   + L   +  LE   +++   +  L  +   + ++ + Q  +  QA Q++ L +
Sbjct: 2425 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2484

Query: 458  LDSL-------DQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQRE 510
             DSL       +QE+ +L     +  A+  ++ E+ Q +++Q +   + +Q L+ S++  
Sbjct: 2485 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEA 2541

Query: 511  KQGLEQATTDLRLTILELERELEELKERERLL 542
            ++   +A   +R    EL++  ++ +++E LL
Sbjct: 2542 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2573



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 105/401 (26%), Positives = 180/401 (44%), Gaps = 48/401 (11%)

Query: 270  ATVGRWAAEQRKDLTRLS-KHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRR- 327
            A   R   E  ++L R   K  EALR +L+  E  +     QA   +Q  + E+ ARRR 
Sbjct: 1604 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1663

Query: 328  QAEED---EQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEE 384
            +AEE    ++ L+E E +KQ+ L E +  +   A  E+EL + R  T+  E + Q L+EE
Sbjct: 1664 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA--EQELIRLRAETEQGEQQRQLLEEE 1721

Query: 385  GER----RAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTE----LDKEKAR 436
              R     AAA ++ Q+LE ++ ++ A++++L+     A ++    S +    L+ E  R
Sbjct: 1722 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1781

Query: 437  VDSMVRHQESL-----QAKQRALLKQLDSLDQEREELRGSLDE----AEAQRARVEEQL- 486
               +      L     +AK++  L + D+  Q  E  R   ++     EA R + E ++ 
Sbjct: 1782 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1841

Query: 487  --QSEREQGQCQLRAQQELLQSLQREKQGLE-QATTDLRLTIL------ELEREL----E 533
              + E E  + +  A+ E  Q  + E+Q  + +A  + RL  L      ELER+     +
Sbjct: 1842 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1901

Query: 534  ELKER----ERLLVAFPDLHR----PTETQIHGGRSSSVESQITCPTDSGNVTDHMERQV 585
             L++R    E +L       +      E ++  GR  S         +   +    +RQ+
Sbjct: 1902 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1961

Query: 586  QANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIPQDRL 626
             A + R R  +E   R+Q  L+   E A+Q    L   +RL
Sbjct: 1962 AAEEERRR--REAEERVQKSLAAEEEAARQRKAALEEVERL 2000



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 58/202 (28%), Positives = 99/202 (49%), Gaps = 17/202 (8%)

Query: 291  EALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTET 350
            E LR  + E E +K+ L+++A  L+  LK E+     Q  + EQ L E +  +Q  L+E 
Sbjct: 2432 ERLREAIAELEREKEKLQQEAKLLQ--LKSEE----MQTVQQEQLLQETQALQQSFLSEK 2485

Query: 351  SDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQ 410
              L  +   +E+E  +  +  Q   AKAQQL+EE       +RQ QQ+E++ Q+L A ++
Sbjct: 2486 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE------QQRQQQQMEQERQRLVASME 2539

Query: 411  LLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ-RALLKQLDSLDQEREELR 469
                R   A + V     EL     +++   R QE L A++ + L +QL  L+++     
Sbjct: 2540 EARRRQHEAEEGVRRKQEELQ----QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2595

Query: 470  GSLDEAEAQRARVEEQLQSERE 491
               +E  A +    + L + R+
Sbjct: 2596 AHSEEVTASQVAATKTLPNGRD 2617



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 64/364 (17%), Positives = 163/364 (44%), Gaps = 36/364 (9%)

Query: 269  AATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGAR--R 326
            A  +G W  + R    R  + ++A+   L +++  ++ LR++   LE+  +  +     +
Sbjct: 1202 ADPLGAWLQDAR----RRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1255

Query: 327  RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGE 386
            R A++    + ++E    QL+T  + L+  +A+  ++ K Q  S   ++          E
Sbjct: 1256 RFAKQYINAIKDYE---LQLVTYKAQLEP-VASPAKKPKVQSGSESVIQEYVDLRTHYSE 1311

Query: 387  RRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQES 446
                  + ++ + E ++++E + +L   +     +++      L+K++   ++  + +  
Sbjct: 1312 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ 1371

Query: 447  LQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQS 506
             + + + L +++      REE   +  +A+ Q+  ++E+LQ  R+  + +++A+    ++
Sbjct: 1372 AEREAKELQQRMQEEVVRREE---AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1428

Query: 507  LQREKQGLEQATTDLRLTILELER-------ELEELKERERLLVA--------FPDLHRP 551
             +R +  +E+    +RL +   ER       EL+ L+ R     A           L R 
Sbjct: 1429 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1488

Query: 552  TETQIHGGRSSSVE--SQITCPTDSGNVTDHMERQVQA-NDIRIRVLQEENGRLQSMLSK 608
             + +    R + VE  S++    ++       +R +QA  ++R++  + E    Q+ + +
Sbjct: 1489 VQDESQRKRQAEVELASRVKAEAEAAR---EKQRALQALEELRLQAEEAERRLRQAEVER 1545

Query: 609  IREV 612
             R+V
Sbjct: 1546 ARQV 1549



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 72/308 (23%), Positives = 126/308 (40%), Gaps = 56/308 (18%)

Query: 282  DLTRLSKHVEALRAQLEEAEGQKDGLRKQ---AGKLEQALKQEQGAR----RRQAEEDEQ 334
            +L      ++ LRAQ E  +   D LR +   A ++ + L+Q  G R     R  E   Q
Sbjct: 1110 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1169

Query: 335  CLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGER-RAAAER 393
             L  W    Q +L +T   + ++  L R+L+  RES   + A  Q  +   E+ +A    
Sbjct: 1170 LLERW----QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1225

Query: 394  QVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQ----- 448
              Q + EQ++Q +A ++ +    E   +   +A   ++  K     +V ++  L+     
Sbjct: 1226 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1285

Query: 449  AKQRALLKQLDSLDQEREELRGSLDE-------------------------AEAQRARVE 483
            AK+  +    +S+ QE  +LR    E                         AE QRA   
Sbjct: 1286 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1345

Query: 484  EQL---------QSEREQGQCQLRAQ-----QELLQSLQREKQGLEQATTDLRLTILELE 529
            E+L         Q +  +   Q +AQ     +EL Q +Q E    E+A  D +     ++
Sbjct: 1346 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1405

Query: 530  RELEELKE 537
             EL++L++
Sbjct: 1406 EELQQLRQ 1413



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 75/305 (24%), Positives = 137/305 (44%), Gaps = 32/305 (10%)

Query: 250  SLGQFQQLVQDSMGLRPLPAATVGRWAAE-QRKDLTRLSKHVEALRAQLEEAEG--QKDG 306
            SL  +Q L +D   +R    AT      E QR+ L  L  H +A     ++A G   +D 
Sbjct: 878  SLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR 937

Query: 307  L--RKQAGKLEQALKQEQGARRRQAEED---EQCLSEWEHDKQQL-LTETSDLKTKMATL 360
            L   ++ G      +Q   +  + A+E+   ++C+SE +  + QL   ET  +      L
Sbjct: 938  LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 997

Query: 361  E----RELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQ---VQQLEAQVQLLV 413
            +    RE  Q+    Q  +A+ + L +   R +A   +V  L E       L ++++L +
Sbjct: 998  DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1057

Query: 414  GRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLD 473
            G+LE   Q    ++  L+K K  +  ++R  +  +   RA  +QL    +E + +  +L 
Sbjct: 1058 GKLE---QVRSLSAIYLEKLKT-ISLVIRGTQGAEEVLRAHEEQL----KEAQAVPATLP 1109

Query: 474  EAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELE 533
            E EA +A +++         + Q  AQQ    +L+ E +G ++    L+    E + E+E
Sbjct: 1110 ELEATKASLKKL--------RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1161

Query: 534  ELKER 538
              +ER
Sbjct: 1162 RWRER 1166



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 44/141 (31%), Positives = 65/141 (46%), Gaps = 13/141 (9%)

Query: 396 QQLEEQVQQLEAQVQLLVGRLE----GAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ 451
           Q+ +E V +LEAQ Q LV             + W S   D +  R  S+   +     +Q
Sbjct: 849 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 908

Query: 452 RALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQ--- 508
           R  L  L+   Q    LR S D   A     E++L +ERE G C    QQ LLQSL+   
Sbjct: 909 RQALHSLELHYQAF--LRDSQD---AGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGA 962

Query: 509 REKQGLEQATTDLRLTILELE 529
           +E+   ++  ++L+   L+LE
Sbjct: 963 QEESRCQRCISELKDIRLQLE 983



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 30/158 (18%), Positives = 67/158 (42%), Gaps = 5/158 (3%)

Query: 253  QFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAG 312
            + +QL QD +           R   +  ++  RL   +E  R +  EAE      +++  
Sbjct: 2501 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2560

Query: 313  KLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQ 372
            +LEQ  +Q++     + +   + L   E   +  L  + ++        + L   R++  
Sbjct: 2561 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2620

Query: 373  AVEAKAQ-QLQEEGERRAAAERQVQQL----EEQVQQL 405
               A+A+ +   +G RR  + +++Q+      E++Q+L
Sbjct: 2621 GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2658


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 95/413 (23%), Positives = 180/413 (43%), Gaps = 44/413 (10%)

Query: 225  ASVQGSLQKVGKVVISLCQSQN--LPSSLGQFQQLVQDSMGLRP-LPAATVGRWAAEQRK 281
            A ++  L ++ K   S  + Q   +  +L Q +Q+ ++ + L+     A  G+  AE   
Sbjct: 1916 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELEL 1973

Query: 282  DLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQ----CLS 337
            +L R+  + E      E+AE        +A +  Q L  E+  RRR+AEE  Q       
Sbjct: 1974 ELGRIRSNAEDTLRSKEQAE-------LEAARQRQ-LAAEEERRRREAEERVQKSLAAEE 2025

Query: 338  EWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQL-QEEGERRAAAERQ-- 394
            E    ++  L E   LK K+     E ++ RE  +   A+  QL QE  ++R  AE +  
Sbjct: 2026 EAARQRKAALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2081

Query: 395  ---VQQLEEQVQQLEAQVQLLVGRLEG-------AGQQVCWASTELDKEKARVDSMVRHQ 444
               VQQ E+++QQ   Q Q ++ +L G       A ++   A  + ++E A+    V   
Sbjct: 2082 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2141

Query: 445  ESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELL 504
            E L+       +         E+LR   ++  A+RA+ E+    +++    ++   ++  
Sbjct: 2142 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2201

Query: 505  QSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSV 564
            +   R+K  +EQ  T LRL + E + +   L E  + L A        E      + S V
Sbjct: 2202 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKA--------EATEAARQRSQV 2253

Query: 565  ESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGR--LQSMLSKIREVAQQ 615
            E ++            ++ +++A +  + +  ++N +  LQ    K+++VA++
Sbjct: 2254 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2306



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 94/412 (22%), Positives = 178/412 (43%), Gaps = 47/412 (11%)

Query: 243  QSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEG 302
            Q +++   L Q +Q  +  +  +   A    R      +++  +   +EA   Q   AEG
Sbjct: 1441 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1500

Query: 303  QKDGLRKQAGKLEQALKQ--EQGARRRQAEEDE---------------QCLSEWEHDKQQ 345
            +   LR +A + E   +Q  E+  R R+  +DE               +  +E   +KQ+
Sbjct: 1501 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1560

Query: 346  LLTETSDLKTKMATLERELKQ-QRESTQAVEAKAQQLQEEGE-----RRAAAERQVQQLE 399
             L    +L+ +    ER L+Q + E  + V+   +  Q   E     +RA+   +  QLE
Sbjct: 1561 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1620

Query: 400  EQVQQLEAQVQLLVGRLEGAGQQVC-------WASTELDKEKARVDSMVRHQESLQAKQR 452
              +Q+    V  L    E   QQ          A  EL++ + + +  +R +  LQA++ 
Sbjct: 1621 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR--LQAEEV 1678

Query: 453  ALLKQLDSLDQEREELRGSLDEAEAQ---RARVEEQLQSEREQGQCQLRAQQELLQSLQR 509
            A  K L   + E+++     +EAE +   R + EEQ   +RE  + +L  Q++L +   +
Sbjct: 1679 AQQKSLAQAEAEKQK-----EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1733

Query: 510  EKQGLEQATTDLRLTIL--ELEREL--EELKERERLLVAFPDLHRPTETQIHGGRSSS-- 563
            ++   EQ    LR      E +R+L  EEL   +R   A     +  E ++   R+    
Sbjct: 1734 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1793

Query: 564  -VESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQ 614
             + S+     +S + ++  +++++A   R R L EE  RL+++  + +   Q
Sbjct: 1794 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1845



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 77/313 (24%), Positives = 144/313 (46%), Gaps = 49/313 (15%)

Query: 327  RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATL-ERELKQQRESTQAVEAKAQQLQEEG 385
            R+ EE+E+   +   ++++ L E      K   L E   + + ++ +  +   Q++QEE 
Sbjct: 1369 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1428

Query: 386  ERRAAA----ERQVQQLEEQVQQL----EAQVQLLVGRLEGAGQQVCWASTELDKEKARV 437
             RR  A    ++Q + ++E++QQL    EA++Q    + E A           ++ + R+
Sbjct: 1429 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA-----------ERSRLRI 1477

Query: 438  DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQ----G 493
            +  +R    ++ +  A  +Q    + E + LR   +EAEAQ+ + +E+ +  R Q     
Sbjct: 1478 EEEIR---VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1534

Query: 494  QCQLRAQQELLQSLQ------REKQGLEQATTDLRLTILELERELE--ELKERERLLVAF 545
            Q + +A+ EL   ++      REKQ   QA  +LRL   E ER L   E++   ++ VA 
Sbjct: 1535 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1594

Query: 546  PDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEE---NGRL 602
                R  E ++   R+S  E            T  +ER +Q   + +  L+EE     + 
Sbjct: 1595 ETAQRSAEAELQSKRASFAEK-----------TAQLERSLQEEHVAVAQLREEAERRAQQ 1643

Query: 603  QSMLSKIREVAQQ 615
            Q+   + RE A++
Sbjct: 1644 QAEAERAREEAER 1656



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 74/272 (27%), Positives = 127/272 (46%), Gaps = 13/272 (4%)

Query: 277  AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
            AE+R+ L  +   +E  R QL EA  Q     ++  K  Q   QE+  RR +A  D Q  
Sbjct: 1383 AEERERLAEVEAALEKQR-QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1441

Query: 337  SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEG--ERRAAAERQ 394
                 ++ Q L ++S+ + +    + E  ++       E +  +LQ E    +R  AE +
Sbjct: 1442 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1501

Query: 395  VQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQ-ESLQAKQRA 453
            +Q L  + ++ EAQ +      E   +QV   S    + +  + S V+ + E+ + KQRA
Sbjct: 1502 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1561

Query: 454  LLKQLDSLDQEREELRGSLDEAEAQRAR-VEEQLQSEREQGQCQLRAQQ----ELLQSLQ 508
            L + L+ L  + EE    L +AE +RAR V+  L++ +   + +L++++    E    L+
Sbjct: 1562 L-QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1620

Query: 509  REKQGLEQATTDLRLTILELERELEELKERER 540
            R  Q    A   LR    E ER  ++  E ER
Sbjct: 1621 RSLQEEHVAVAQLR---EEAERRAQQQAEAER 1649



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 73/287 (25%), Positives = 136/287 (47%), Gaps = 24/287 (8%)

Query: 276  AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKL-------EQALKQEQGARRRQ 328
            A E  +  +++ + + ++R Q+EE    K  +  +   L        Q   QE+  + +Q
Sbjct: 2243 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2302

Query: 329  AEEDEQCLSEWEHDKQQL--LTETSDLKTKMATLERELKQQRESTQA---VEAKAQQLQE 383
              E+   LS    +  +L  L E  DL  + A  E+ LK++ ++ Q    ++A+A+ LQ+
Sbjct: 2303 VAEEAARLSVAAQEAARLRQLAE-EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2361

Query: 384  EGERRAAAERQVQQLEEQV-QQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVR 442
            + E      R++Q+ +EQ+ QQL  + Q     LE   Q+    S E ++ K RV  M R
Sbjct: 2362 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2421

Query: 443  HQESLQAKQRALLKQLDSLDQE--REELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQ 500
             Q   +   +   KQ + + ++  R EL      A  ++  + + L+ +R+Q        
Sbjct: 2422 AQARAEEDAQRFRKQAEEIGEKLHRTEL------ATQEKVTLVQTLEIQRQQSDHDAERL 2475

Query: 501  QELLQSLQREKQGLEQATTDLRLTILELERELEE--LKERERLLVAF 545
            +E +  L+REK+ L+Q    L+L   E++   +E  L+E + L  +F
Sbjct: 2476 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2522



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 74/270 (27%), Positives = 124/270 (45%), Gaps = 23/270 (8%)

Query: 292  ALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGA---RRRQAEEDEQCLSEWEHDKQQLLT 348
            A R+   E + ++    ++  +LE++L++E  A    R +AE   Q  +E E  +++   
Sbjct: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656

Query: 349  ETS--DLKTKMATLER----ELKQQRESTQA-VEAKAQQLQEEGERRAAAERQ-VQQLEE 400
            E     LK   A   R    E+ QQ+   QA  E + ++ + E  RR  AE Q V+Q E 
Sbjct: 1657 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1716

Query: 401  QVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDS 460
              Q+LE Q QL     EG  QQ   A  EL + +A  +   + ++ L+ +   L ++  +
Sbjct: 1717 AEQELEKQRQLA----EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1772

Query: 461  LDQEREELRGSLDEAEAQ-------RARVEEQLQSEREQGQCQLRAQQELLQSLQREKQG 513
              Q+R+EL   L +  A+       +AR EE+ +S  E+ + +L A+    + L  E   
Sbjct: 1773 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1832

Query: 514  LEQATTDL-RLTILELERELEELKERERLL 542
            L     +  R   L  E    +  E ER+L
Sbjct: 1833 LRALAEEAKRQRQLAEEDAARQRAEAERVL 1862



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 69/332 (20%), Positives = 152/332 (45%), Gaps = 26/332 (7%)

Query: 227  VQGSLQKVGKVVISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRL 286
            +Q   +K+ +V     +         + +QL ++ +  +   A  + +   +  ++ TRL
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2352

Query: 287  SKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQL 346
                E L+ Q E A+ Q   L++   ++ Q L +E    +R  E + Q        + ++
Sbjct: 2353 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ-------RQLEM 2405

Query: 347  LTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQ----VQQLEEQV 402
              E   LK ++A + R   +  E  Q    +A+++ E+  R   A ++    VQ LE Q 
Sbjct: 2406 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2465

Query: 403  QQLEAQVQLL---VGRLEGAGQQVCWASTELDKEKARVDSMVRHQ--ESLQAKQRALLKQ 457
            QQ +   + L   +  LE   +++   +  L  +   + ++ + Q  +  QA Q++ L +
Sbjct: 2466 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2525

Query: 458  LDSL-------DQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQRE 510
             DSL       +QE+ +L     +  A+  ++ E+ Q +++Q +   + +Q L+ S++  
Sbjct: 2526 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEA 2582

Query: 511  KQGLEQATTDLRLTILELERELEELKERERLL 542
            ++   +A   +R    EL++  ++ +++E LL
Sbjct: 2583 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2614



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 105/401 (26%), Positives = 180/401 (44%), Gaps = 48/401 (11%)

Query: 270  ATVGRWAAEQRKDLTRLS-KHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRR- 327
            A   R   E  ++L R   K  EALR +L+  E  +     QA   +Q  + E+ ARRR 
Sbjct: 1645 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1704

Query: 328  QAEED---EQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEE 384
            +AEE    ++ L+E E +KQ+ L E +  +   A  E+EL + R  T+  E + Q L+EE
Sbjct: 1705 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA--EQELIRLRAETEQGEQQRQLLEEE 1762

Query: 385  GER----RAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTE----LDKEKAR 436
              R     AAA ++ Q+LE ++ ++ A++++L+     A ++    S +    L+ E  R
Sbjct: 1763 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1822

Query: 437  VDSMVRHQESL-----QAKQRALLKQLDSLDQEREELRGSLDE----AEAQRARVEEQL- 486
               +      L     +AK++  L + D+  Q  E  R   ++     EA R + E ++ 
Sbjct: 1823 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1882

Query: 487  --QSEREQGQCQLRAQQELLQSLQREKQGLE-QATTDLRLTIL------ELEREL----E 533
              + E E  + +  A+ E  Q  + E+Q  + +A  + RL  L      ELER+     +
Sbjct: 1883 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1942

Query: 534  ELKER----ERLLVAFPDLHR----PTETQIHGGRSSSVESQITCPTDSGNVTDHMERQV 585
             L++R    E +L       +      E ++  GR  S         +   +    +RQ+
Sbjct: 1943 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2002

Query: 586  QANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIPQDRL 626
             A + R R  +E   R+Q  L+   E A+Q    L   +RL
Sbjct: 2003 AAEEERRR--REAEERVQKSLAAEEEAARQRKAALEEVERL 2041



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 58/202 (28%), Positives = 99/202 (49%), Gaps = 17/202 (8%)

Query: 291  EALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTET 350
            E LR  + E E +K+ L+++A  L+  LK E+     Q  + EQ L E +  +Q  L+E 
Sbjct: 2473 ERLREAIAELEREKEKLQQEAKLLQ--LKSEE----MQTVQQEQLLQETQALQQSFLSEK 2526

Query: 351  SDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQ 410
              L  +   +E+E  +  +  Q   AKAQQL+EE       +RQ QQ+E++ Q+L A ++
Sbjct: 2527 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE------QQRQQQQMEQERQRLVASME 2580

Query: 411  LLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ-RALLKQLDSLDQEREELR 469
                R   A + V     EL     +++   R QE L A++ + L +QL  L+++     
Sbjct: 2581 EARRRQHEAEEGVRRKQEELQ----QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2636

Query: 470  GSLDEAEAQRARVEEQLQSERE 491
               +E  A +    + L + R+
Sbjct: 2637 AHSEEVTASQVAATKTLPNGRD 2658



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 64/364 (17%), Positives = 163/364 (44%), Gaps = 36/364 (9%)

Query: 269  AATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGAR--R 326
            A  +G W  + R    R  + ++A+   L +++  ++ LR++   LE+  +  +     +
Sbjct: 1243 ADPLGAWLQDAR----RRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1296

Query: 327  RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGE 386
            R A++    + ++E    QL+T  + L+  +A+  ++ K Q  S   ++          E
Sbjct: 1297 RFAKQYINAIKDYE---LQLVTYKAQLEP-VASPAKKPKVQSGSESVIQEYVDLRTHYSE 1352

Query: 387  RRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQES 446
                  + ++ + E ++++E + +L   +     +++      L+K++   ++  + +  
Sbjct: 1353 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ 1412

Query: 447  LQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQS 506
             + + + L +++      REE   +  +A+ Q+  ++E+LQ  R+  + +++A+    ++
Sbjct: 1413 AEREAKELQQRMQEEVVRREE---AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1469

Query: 507  LQREKQGLEQATTDLRLTILELER-------ELEELKERERLLVA--------FPDLHRP 551
             +R +  +E+    +RL +   ER       EL+ L+ R     A           L R 
Sbjct: 1470 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1529

Query: 552  TETQIHGGRSSSVE--SQITCPTDSGNVTDHMERQVQA-NDIRIRVLQEENGRLQSMLSK 608
             + +    R + VE  S++    ++       +R +QA  ++R++  + E    Q+ + +
Sbjct: 1530 VQDESQRKRQAEVELASRVKAEAEAAR---EKQRALQALEELRLQAEEAERRLRQAEVER 1586

Query: 609  IREV 612
             R+V
Sbjct: 1587 ARQV 1590



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 72/308 (23%), Positives = 126/308 (40%), Gaps = 56/308 (18%)

Query: 282  DLTRLSKHVEALRAQLEEAEGQKDGLRKQ---AGKLEQALKQEQGAR----RRQAEEDEQ 334
            +L      ++ LRAQ E  +   D LR +   A ++ + L+Q  G R     R  E   Q
Sbjct: 1151 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1210

Query: 335  CLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGER-RAAAER 393
             L  W    Q +L +T   + ++  L R+L+  RES   + A  Q  +   E+ +A    
Sbjct: 1211 LLERW----QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1266

Query: 394  QVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQ----- 448
              Q + EQ++Q +A ++ +    E   +   +A   ++  K     +V ++  L+     
Sbjct: 1267 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1326

Query: 449  AKQRALLKQLDSLDQEREELRGSLDE-------------------------AEAQRARVE 483
            AK+  +    +S+ QE  +LR    E                         AE QRA   
Sbjct: 1327 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1386

Query: 484  EQL---------QSEREQGQCQLRAQ-----QELLQSLQREKQGLEQATTDLRLTILELE 529
            E+L         Q +  +   Q +AQ     +EL Q +Q E    E+A  D +     ++
Sbjct: 1387 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1446

Query: 530  RELEELKE 537
             EL++L++
Sbjct: 1447 EELQQLRQ 1454



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 75/305 (24%), Positives = 137/305 (44%), Gaps = 32/305 (10%)

Query: 250  SLGQFQQLVQDSMGLRPLPAATVGRWAAE-QRKDLTRLSKHVEALRAQLEEAEG--QKDG 306
            SL  +Q L +D   +R    AT      E QR+ L  L  H +A     ++A G   +D 
Sbjct: 919  SLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR 978

Query: 307  L--RKQAGKLEQALKQEQGARRRQAEED---EQCLSEWEHDKQQL-LTETSDLKTKMATL 360
            L   ++ G      +Q   +  + A+E+   ++C+SE +  + QL   ET  +      L
Sbjct: 979  LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 1038

Query: 361  E----RELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQ---VQQLEAQVQLLV 413
            +    RE  Q+    Q  +A+ + L +   R +A   +V  L E       L ++++L +
Sbjct: 1039 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1098

Query: 414  GRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLD 473
            G+LE   Q    ++  L+K K  +  ++R  +  +   RA  +QL    +E + +  +L 
Sbjct: 1099 GKLE---QVRSLSAIYLEKLKT-ISLVIRGTQGAEEVLRAHEEQL----KEAQAVPATLP 1150

Query: 474  EAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELE 533
            E EA +A +++         + Q  AQQ    +L+ E +G ++    L+    E + E+E
Sbjct: 1151 ELEATKASLKKL--------RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1202

Query: 534  ELKER 538
              +ER
Sbjct: 1203 RWRER 1207



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 44/141 (31%), Positives = 65/141 (46%), Gaps = 13/141 (9%)

Query: 396  QQLEEQVQQLEAQVQLLVGRLE----GAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ 451
            Q+ +E V +LEAQ Q LV             + W S   D +  R  S+   +     +Q
Sbjct: 890  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 949

Query: 452  RALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQ--- 508
            R  L  L+   Q    LR S D   A     E++L +ERE G C    QQ LLQSL+   
Sbjct: 950  RQALHSLELHYQAF--LRDSQD---AGGFGPEDRLMAEREYGSCSHHYQQ-LLQSLEQGA 1003

Query: 509  REKQGLEQATTDLRLTILELE 529
            +E+   ++  ++L+   L+LE
Sbjct: 1004 QEESRCQRCISELKDIRLQLE 1024



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 30/158 (18%), Positives = 67/158 (42%), Gaps = 5/158 (3%)

Query: 253  QFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAG 312
            + +QL QD +           R   +  ++  RL   +E  R +  EAE      +++  
Sbjct: 2542 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2601

Query: 313  KLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQ 372
            +LEQ  +Q++     + +   + L   E   +  L  + ++        + L   R++  
Sbjct: 2602 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2661

Query: 373  AVEAKAQ-QLQEEGERRAAAERQVQQL----EEQVQQL 405
               A+A+ +   +G RR  + +++Q+      E++Q+L
Sbjct: 2662 GPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRL 2699


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 88/362 (24%), Positives = 161/362 (44%), Gaps = 41/362 (11%)

Query: 273  GRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQG-------AR 325
            G W     K    L   V  LRA+L   +  +    ++  +LE  L++ QG       AR
Sbjct: 1245 GAW----EKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERAR 1300

Query: 326  RRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQL-QEE 384
               AE+ ++  +E E+    L    ++ ++K   L +EL     ST+A    AQ+L QEE
Sbjct: 1301 AEAAEKLQRAQAELENVSGAL----NEAESKTIRLSKELS----STEAQLHDAQELLQEE 1352

Query: 385  GERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQ 444
               + A   +V+ +E +   L  Q++      E AG+++  A  +L + + R +      
Sbjct: 1353 TRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGAL 1412

Query: 445  ESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELL 504
            E+ +  +R   ++ ++L Q   E   ++D  E  R R    LQ E +     L  Q++L+
Sbjct: 1413 EAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRR----LQQELDDATMDLEQQRQLV 1468

Query: 505  QSLQREKQGLEQATTDLRLTIL----ELERELEELKERE-------RLLVAFPDLHRPTE 553
             +L+++++  +Q   + +  +L    E ER   E +ERE       R L    +     E
Sbjct: 1469 STLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELE 1528

Query: 554  TQIHGGRSSSVESQITCPTDSGNVTDHMER-----QVQANDIRIRVLQEENGRLQSMLSK 608
             Q    R + +E+ ++   D G     +ER     +  AND+R +V + E+    +  +K
Sbjct: 1529 RQNRALR-AELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAK 1587

Query: 609  IR 610
            +R
Sbjct: 1588 LR 1589



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 80/308 (25%), Positives = 138/308 (44%), Gaps = 44/308 (14%)

Query: 267  LPAATVGRWAAE-QRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQ----- 320
            L +  V R  AE QR+DL    + +EALR +LE+     +  ++   K EQ + +     
Sbjct: 1152 LESERVARTKAEKQRRDL---GEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTL 1208

Query: 321  EQGARRRQAEEDE------QCLSE--------------WEHDKQQLLTETSDLKTKMATL 360
            E+  R  +A   E      Q L E              WE  +  L  E S+L+ ++++L
Sbjct: 1209 EEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL 1268

Query: 361  ERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAG 420
            +   ++  +  + +E    QLQE   R    ER   +  E++Q+ +A+++ + G L  A 
Sbjct: 1269 QTARQEGEQRRRRLEL---QLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAE 1325

Query: 421  QQVCWASTELDKEKARV-DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQR 479
             +    S EL   +A++ D+    QE  +AK  AL  ++ +++ E   LR  L+E  A R
Sbjct: 1326 SKTIRLSKELSSTEAQLHDAQELLQEETRAK-LALGSRVRAMEAEAAGLREQLEEEAAAR 1384

Query: 480  ARVEEQLQS----------EREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELE 529
             R   +LQ+           +E+    L A +E  +   RE + L Q   +   T+  LE
Sbjct: 1385 ERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLE 1444

Query: 530  RELEELKE 537
            R    L++
Sbjct: 1445 RGRRRLQQ 1452



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 96/375 (25%), Positives = 171/375 (45%), Gaps = 47/375 (12%)

Query: 265  RPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALK-QEQG 323
            R   A ++ R   E+++    L +   ALRA+LE     KD + K   +LE+A +  EQ 
Sbjct: 1506 REARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQA 1565

Query: 324  AR--RRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAK-AQQ 380
            A   R Q  E E  L+  E  K +L      LKT+    ER+L+ + E+ +    + A+Q
Sbjct: 1566 ANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQH---ERDLQGRDEAGEERRRQLAKQ 1622

Query: 381  LQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSM 440
            L++    R    +Q        ++LE +++ L  ++  AGQ          KE+A     
Sbjct: 1623 LRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ---------GKEEA----- 1668

Query: 441  VRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQ 500
            V+    +QA+ + L ++++     REE+     E+E +   +E ++   +E+     RA+
Sbjct: 1669 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1728

Query: 501  QELLQSLQREKQGLEQATTDL-RLTILELEREL--------EELKERERLLVAFPDLHRP 551
            ++  Q   R++   E A  +L +  ILE +R+L        EEL+E +       D +R 
Sbjct: 1729 RQAQQ--DRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRK 1786

Query: 552  TETQIHGGRSS-SVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENG---------- 600
               Q+    +  S E   +   +SG     +ERQ+Q  ++R R+ +E+ G          
Sbjct: 1787 LLLQVESLTTELSAERSFSAKAESGR--QQLERQIQ--ELRGRLGEEDAGARARHKMTIA 1842

Query: 601  RLQSMLSKIREVAQQ 615
             L+S L++  E  +Q
Sbjct: 1843 ALESKLAQAEEQLEQ 1857



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 95/403 (23%), Positives = 167/403 (41%), Gaps = 48/403 (11%)

Query: 241  LCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEA 300
            L + QN  S L + ++L++D +      AA       E+ K L +L    EA  A +E+ 
Sbjct: 1014 LLEDQN--SKLSKERKLLEDRLAEFSSQAAE----EEEKVKSLNKLRLKYEATIADMEDR 1067

Query: 301  EGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATL 360
              +++  R++  KL++ L  E    + Q  E +Q   E    + QL  +  +L+  +A  
Sbjct: 1068 LRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEEL---RAQLGRKEEELQAALARA 1124

Query: 361  ERE-------LKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLV 413
            E E       LK  RE+  A+    + L+ E   R  AE+Q + L E+++ L  +++  +
Sbjct: 1125 EDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTL 1184

Query: 414  GRLEGAGQQVCWASTELDKEKARVDSMVR-----HQESLQAKQRALLKQLDSLDQER--- 465
                   +       E+ + K  ++   R      QE  Q   +AL +  + L+Q R   
Sbjct: 1185 DSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK 1244

Query: 466  ---EELRGSLDEAEAQRARVE-EQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDL 521
               E+ R +L EAE    R E   LQ+ R++G+ + R  +  LQ +Q      E+A  + 
Sbjct: 1245 GAWEKTRLAL-EAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEA 1303

Query: 522  RLTILELERELEE----LKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNV 577
               +   + ELE     L E E   +        TE Q+H               D+  +
Sbjct: 1304 AEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH---------------DAQEL 1348

Query: 578  TDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKL 620
                 R   A   R+R ++ E   L+  L +     ++ G +L
Sbjct: 1349 LQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGREL 1391



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 85/362 (23%), Positives = 152/362 (41%), Gaps = 46/362 (12%)

Query: 277  AEQRKDLTRLSKHVEALRAQLEEA----EGQKD---GLRKQAGKLEQALKQEQGARRRQA 329
            AE+ + + RL +    L+ +L++A    E Q+     L K+  K +Q L +E+ A  R  
Sbjct: 1434 AEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAV 1493

Query: 330  EEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRA 389
            EE E+  +E    + + L+ T  L+ +    E   +Q R     +EA      + G+   
Sbjct: 1494 EERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH 1553

Query: 390  AAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVR-HQESLQ 448
              ER  +  E+    L AQV  L   L  A          +   K + +  ++   E+ +
Sbjct: 1554 ELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGE 1613

Query: 449  AKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQ 508
             ++R L KQL   + ER+E R     A A R ++E +L              +EL   + 
Sbjct: 1614 ERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGEL--------------EELKAQMA 1659

Query: 509  REKQGLEQATTDLR---LTILELERELEELK-ERERLLVAFPDLHRPTETQIHGGRSSSV 564
               QG E+A   LR     + EL RE+EE +  RE +       +R +E ++ G     +
Sbjct: 1660 SAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIF----SQNRESEKRLKG-----L 1710

Query: 565  ESQITCPTDSGNVTDHMERQVQAN-----------DIRIRVLQEENGRLQSMLSKIREVA 613
            E+++    +    +D   RQ Q +           ++    + EE  +L+  L ++ E  
Sbjct: 1711 EAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEEL 1770

Query: 614  QQ 615
            ++
Sbjct: 1771 EE 1772



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 87/365 (23%), Positives = 159/365 (43%), Gaps = 43/365 (11%)

Query: 280  RKDLTRLSKHVEA----LRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQC 335
            R++L +L + ++     L+ Q+ E + + + LR Q G+ E+ L+        +     Q 
Sbjct: 1075 RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQL 1134

Query: 336  LSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQE-------EGERR 388
            L      +  L     DL+++     +  KQ+R+  + +EA   +L++       + E R
Sbjct: 1135 LKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELR 1194

Query: 389  AAAERQVQQ----LEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQ 444
            +  E++V +    LEE+ +  EA VQ L  R    GQ +   + +L++ +    +  + +
Sbjct: 1195 SKREQEVTELKKTLEEETRIHEAAVQELRQR---HGQALGELAEQLEQARRGKGAWEKTR 1251

Query: 445  ESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELL 504
             +L+A+   L  +L SL   R+       E E +R R+E QLQ  + +     RA+ E  
Sbjct: 1252 LALEAEVSELRAELSSLQTARQ-------EGEQRRRRLELQLQEVQGRAGDGERARAEAA 1304

Query: 505  QSLQREKQGLEQ---ATTDLRLTILELEREL-----------EELKERERLLVAFPDLHR 550
            + LQR +  LE    A  +     + L +EL           E L+E  R  +A     R
Sbjct: 1305 EKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVR 1364

Query: 551  PTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIR 610
              E +  G R   +E +      +G   +    Q Q ++ R R  +EE G L++     R
Sbjct: 1365 AMEAEAAGLR-EQLEEEAAARERAGR--ELQTAQAQLSEWR-RRQEEEAGALEAGEEARR 1420

Query: 611  EVAQQ 615
              A++
Sbjct: 1421 RAARE 1425



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 94/424 (22%), Positives = 172/424 (40%), Gaps = 63/424 (14%)

Query: 293  LRAQLEEAEGQKDGLRKQA-----------GKLEQALKQEQGARRRQAEEDEQCLSEWEH 341
            L  QL +AE ++D  RKQ            G+LE+ LK +  +  +  EE  + L + + 
Sbjct: 1619 LAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE-LKAQMASAGQGKEEAVKQLRKMQA 1677

Query: 342  DKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQ 401
              ++L  E  + +T    +  + ++  +  + +EA+  +LQEE      A RQ QQ  ++
Sbjct: 1678 QMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDE 1737

Query: 402  VQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSL 461
            +    A   L    +    +Q+     +L++E     S   + E L  + R LL Q++SL
Sbjct: 1738 MADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQS---NSELLNDRYRKLLLQVESL 1794

Query: 462  DQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDL 521
              E    R    +AE+ R ++E Q+              QEL   L  E  G   A    
Sbjct: 1795 TTELSAERSFSAKAESGRQQLERQI--------------QELRGRLGEEDAG---ARARH 1837

Query: 522  RLTILELERELEELKERERLLVAFPDLHRPTETQIHGGR-----SSSVESQITCPTDSGN 576
            ++TI  LE +L + +E+         L + T  +I  G+        ++  +    +   
Sbjct: 1838 KMTIAALESKLAQAEEQ---------LEQETRERILSGKLVRRAEKRLKEVVLQVEEERR 1888

Query: 577  VTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIPQDRLWSPSSKGTQG 636
            V D +  Q++  ++R++ L+ +          + E  ++       + RL       T+ 
Sbjct: 1889 VADQLRDQLEKGNLRVKQLKRQ----------LEEAEEEASRAQAGRRRLQRELEDVTES 1938

Query: 637  ATPPVQAKSTSPGPLGRQHLP-SSRTGRTL------LGQPCTSPPRQPCTSPPRQPCTSP 689
            A    +  +T    L R  L  ++RT R +      +     +   QP + P  +P  SP
Sbjct: 1939 AESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQPGSGPSPEPEGSP 1998

Query: 690  PRQP 693
            P  P
Sbjct: 1999 PAHP 2002



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 90/357 (25%), Positives = 156/357 (43%), Gaps = 48/357 (13%)

Query: 277  AEQRKDLTRLSKHVEALRAQL----EEAEGQKDGLRKQAGKLEQALKQEQGARRR---QA 329
            AEQ +    L    E  R +L    +E E     L  + G+ E+  +Q Q  ++R     
Sbjct: 918  AEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHI 977

Query: 330  EEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELK--QQRESTQAVEAKA--QQLQEEG 385
            +E E  L   E  +Q+L  E    + KM   E +L   + + S  + E K    +L E  
Sbjct: 978  QELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFS 1037

Query: 386  ERRAAAERQVQQLEEQVQQLEAQVQLLVGRL--EGAGQQVCWASTELDKEKARVDSMVRH 443
             + A  E +V+ L +   + EA +  +  RL  E  G+Q      EL+K K R+D     
Sbjct: 1038 SQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQ------ELEKLKRRLD----- 1086

Query: 444  QESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQEL 503
                  +   L +Q+    Q  EELR       AQ  R EE+LQ+   + + +  A+ +L
Sbjct: 1087 -----GESSELQEQMVEQQQRAEELR-------AQLGRKEEELQAALARAEDEGGARAQL 1134

Query: 504  LQSLQREKQGLEQATTDL---RLTILELERELEEL-KERERLLVAFPDLHRPTETQIHGG 559
            L+SL+  +  L +A  DL   R+   + E++  +L +E E L     D    T  Q    
Sbjct: 1135 LKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE-- 1192

Query: 560  RSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQG 616
              S  E ++T       +   +E + + ++  ++ L++ +G+    L++  E A++G
Sbjct: 1193 LRSKREQEVT------ELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG 1243



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 46/194 (23%), Positives = 91/194 (46%), Gaps = 32/194 (16%)

Query: 356  KMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGR 415
            ++ T  + L Q     + ++A+AQ+LQ+                  VQ+L+ Q    VG 
Sbjct: 861  RLFTKVKPLLQVTRQDEVLQARAQELQK------------------VQELQQQSAREVGE 902

Query: 416  LEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEA 475
            L+G   Q       L++E+AR+   +R +  L A+      +L +  QE E +   L+  
Sbjct: 903  LQGRVAQ-------LEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEAR 955

Query: 476  EAQRARVEEQLQSEREQGQCQLRAQQELLQSLQ--REKQGLEQATTDLRL-----TILEL 528
              +      Q+Q+E+++ Q  ++  +  L++ +  R+K  LE+ TT+ ++      +L L
Sbjct: 956  VGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLL 1015

Query: 529  ERELEELKERERLL 542
            E +  +L +  +LL
Sbjct: 1016 EDQNSKLSKERKLL 1029



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 25/88 (28%), Positives = 41/88 (46%), Gaps = 4/88 (4%)

Query: 281  KDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWE 340
            K + R  K ++ +  Q+EE     D LR Q  K    +KQ     +RQ EE E+  S  +
Sbjct: 1867 KLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQ----LKRQLEEAEEEASRAQ 1922

Query: 341  HDKQQLLTETSDLKTKMATLERELKQQR 368
              +++L  E  D+     ++ RE+   R
Sbjct: 1923 AGRRRLQRELEDVTESAESMNREVTTLR 1950



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 31/127 (24%), Positives = 58/127 (45%), Gaps = 17/127 (13%)

Query: 290  VEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTE 349
            +E+  AQ EE   Q+   R  +GKL +  ++       Q EE+ +   +    + QL  E
Sbjct: 1844 LESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQL---RDQL--E 1898

Query: 350  TSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQV 409
              +L+ K   L+R+L++  E     +A  ++LQ          R+++ + E  + +  +V
Sbjct: 1899 KGNLRVKQ--LKRQLEEAEEEASRAQAGRRRLQ----------RELEDVTESAESMNREV 1946

Query: 410  QLLVGRL 416
              L  RL
Sbjct: 1947 TTLRNRL 1953


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 88/362 (24%), Positives = 161/362 (44%), Gaps = 41/362 (11%)

Query: 273  GRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQG-------AR 325
            G W     K    L   V  LRA+L   +  +    ++  +LE  L++ QG       AR
Sbjct: 1237 GAW----EKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERAR 1292

Query: 326  RRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQL-QEE 384
               AE+ ++  +E E+    L    ++ ++K   L +EL     ST+A    AQ+L QEE
Sbjct: 1293 AEAAEKLQRAQAELENVSGAL----NEAESKTIRLSKELS----STEAQLHDAQELLQEE 1344

Query: 385  GERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQ 444
               + A   +V+ +E +   L  Q++      E AG+++  A  +L + + R +      
Sbjct: 1345 TRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGAL 1404

Query: 445  ESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELL 504
            E+ +  +R   ++ ++L Q   E   ++D  E  R R    LQ E +     L  Q++L+
Sbjct: 1405 EAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRR----LQQELDDATMDLEQQRQLV 1460

Query: 505  QSLQREKQGLEQATTDLRLTIL----ELERELEELKERE-------RLLVAFPDLHRPTE 553
             +L+++++  +Q   + +  +L    E ER   E +ERE       R L    +     E
Sbjct: 1461 STLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELE 1520

Query: 554  TQIHGGRSSSVESQITCPTDSGNVTDHMER-----QVQANDIRIRVLQEENGRLQSMLSK 608
             Q    R + +E+ ++   D G     +ER     +  AND+R +V + E+    +  +K
Sbjct: 1521 RQNRALR-AELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAK 1579

Query: 609  IR 610
            +R
Sbjct: 1580 LR 1581



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 80/308 (25%), Positives = 138/308 (44%), Gaps = 44/308 (14%)

Query: 267  LPAATVGRWAAE-QRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQ----- 320
            L +  V R  AE QR+DL    + +EALR +LE+     +  ++   K EQ + +     
Sbjct: 1144 LESERVARTKAEKQRRDL---GEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTL 1200

Query: 321  EQGARRRQAEEDE------QCLSE--------------WEHDKQQLLTETSDLKTKMATL 360
            E+  R  +A   E      Q L E              WE  +  L  E S+L+ ++++L
Sbjct: 1201 EEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL 1260

Query: 361  ERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAG 420
            +   ++  +  + +E    QLQE   R    ER   +  E++Q+ +A+++ + G L  A 
Sbjct: 1261 QTARQEGEQRRRRLEL---QLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAE 1317

Query: 421  QQVCWASTELDKEKARV-DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQR 479
             +    S EL   +A++ D+    QE  +AK  AL  ++ +++ E   LR  L+E  A R
Sbjct: 1318 SKTIRLSKELSSTEAQLHDAQELLQEETRAK-LALGSRVRAMEAEAAGLREQLEEEAAAR 1376

Query: 480  ARVEEQLQS----------EREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELE 529
             R   +LQ+           +E+    L A +E  +   RE + L Q   +   T+  LE
Sbjct: 1377 ERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLE 1436

Query: 530  RELEELKE 537
            R    L++
Sbjct: 1437 RGRRRLQQ 1444



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 96/375 (25%), Positives = 171/375 (45%), Gaps = 47/375 (12%)

Query: 265  RPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALK-QEQG 323
            R   A ++ R   E+++    L +   ALRA+LE     KD + K   +LE+A +  EQ 
Sbjct: 1498 REARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQA 1557

Query: 324  AR--RRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAK-AQQ 380
            A   R Q  E E  L+  E  K +L      LKT+    ER+L+ + E+ +    + A+Q
Sbjct: 1558 ANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQH---ERDLQGRDEAGEERRRQLAKQ 1614

Query: 381  LQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSM 440
            L++    R    +Q        ++LE +++ L  ++  AGQ          KE+A     
Sbjct: 1615 LRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ---------GKEEA----- 1660

Query: 441  VRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQ 500
            V+    +QA+ + L ++++     REE+     E+E +   +E ++   +E+     RA+
Sbjct: 1661 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1720

Query: 501  QELLQSLQREKQGLEQATTDL-RLTILELEREL--------EELKERERLLVAFPDLHRP 551
            ++  Q   R++   E A  +L +  ILE +R+L        EEL+E +       D +R 
Sbjct: 1721 RQAQQ--DRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRK 1778

Query: 552  TETQIHGGRSS-SVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENG---------- 600
               Q+    +  S E   +   +SG     +ERQ+Q  ++R R+ +E+ G          
Sbjct: 1779 LLLQVESLTTELSAERSFSAKAESGR--QQLERQIQ--ELRGRLGEEDAGARARHKMTIA 1834

Query: 601  RLQSMLSKIREVAQQ 615
             L+S L++  E  +Q
Sbjct: 1835 ALESKLAQAEEQLEQ 1849



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 95/403 (23%), Positives = 167/403 (41%), Gaps = 48/403 (11%)

Query: 241  LCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEA 300
            L + QN  S L + ++L++D +      AA       E+ K L +L    EA  A +E+ 
Sbjct: 1006 LLEDQN--SKLSKERKLLEDRLAEFSSQAAE----EEEKVKSLNKLRLKYEATIADMEDR 1059

Query: 301  EGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATL 360
              +++  R++  KL++ L  E    + Q  E +Q   E    + QL  +  +L+  +A  
Sbjct: 1060 LRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEEL---RAQLGRKEEELQAALARA 1116

Query: 361  ERE-------LKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLV 413
            E E       LK  RE+  A+    + L+ E   R  AE+Q + L E+++ L  +++  +
Sbjct: 1117 EDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTL 1176

Query: 414  GRLEGAGQQVCWASTELDKEKARVDSMVR-----HQESLQAKQRALLKQLDSLDQER--- 465
                   +       E+ + K  ++   R      QE  Q   +AL +  + L+Q R   
Sbjct: 1177 DSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK 1236

Query: 466  ---EELRGSLDEAEAQRARVE-EQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDL 521
               E+ R +L EAE    R E   LQ+ R++G+ + R  +  LQ +Q      E+A  + 
Sbjct: 1237 GAWEKTRLAL-EAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEA 1295

Query: 522  RLTILELERELEE----LKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNV 577
               +   + ELE     L E E   +        TE Q+H               D+  +
Sbjct: 1296 AEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH---------------DAQEL 1340

Query: 578  TDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKL 620
                 R   A   R+R ++ E   L+  L +     ++ G +L
Sbjct: 1341 LQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGREL 1383



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 85/362 (23%), Positives = 152/362 (41%), Gaps = 46/362 (12%)

Query: 277  AEQRKDLTRLSKHVEALRAQLEEA----EGQKD---GLRKQAGKLEQALKQEQGARRRQA 329
            AE+ + + RL +    L+ +L++A    E Q+     L K+  K +Q L +E+ A  R  
Sbjct: 1426 AEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAV 1485

Query: 330  EEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRA 389
            EE E+  +E    + + L+ T  L+ +    E   +Q R     +EA      + G+   
Sbjct: 1486 EERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH 1545

Query: 390  AAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVR-HQESLQ 448
              ER  +  E+    L AQV  L   L  A          +   K + +  ++   E+ +
Sbjct: 1546 ELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGE 1605

Query: 449  AKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQ 508
             ++R L KQL   + ER+E R     A A R ++E +L              +EL   + 
Sbjct: 1606 ERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGEL--------------EELKAQMA 1651

Query: 509  REKQGLEQATTDLR---LTILELERELEELK-ERERLLVAFPDLHRPTETQIHGGRSSSV 564
               QG E+A   LR     + EL RE+EE +  RE +       +R +E ++ G     +
Sbjct: 1652 SAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIF----SQNRESEKRLKG-----L 1702

Query: 565  ESQITCPTDSGNVTDHMERQVQAN-----------DIRIRVLQEENGRLQSMLSKIREVA 613
            E+++    +    +D   RQ Q +           ++    + EE  +L+  L ++ E  
Sbjct: 1703 EAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEEL 1762

Query: 614  QQ 615
            ++
Sbjct: 1763 EE 1764



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 87/365 (23%), Positives = 159/365 (43%), Gaps = 43/365 (11%)

Query: 280  RKDLTRLSKHVEA----LRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQC 335
            R++L +L + ++     L+ Q+ E + + + LR Q G+ E+ L+        +     Q 
Sbjct: 1067 RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQL 1126

Query: 336  LSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQE-------EGERR 388
            L      +  L     DL+++     +  KQ+R+  + +EA   +L++       + E R
Sbjct: 1127 LKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELR 1186

Query: 389  AAAERQVQQ----LEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQ 444
            +  E++V +    LEE+ +  EA VQ L  R    GQ +   + +L++ +    +  + +
Sbjct: 1187 SKREQEVTELKKTLEEETRIHEAAVQELRQR---HGQALGELAEQLEQARRGKGAWEKTR 1243

Query: 445  ESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELL 504
             +L+A+   L  +L SL   R+       E E +R R+E QLQ  + +     RA+ E  
Sbjct: 1244 LALEAEVSELRAELSSLQTARQ-------EGEQRRRRLELQLQEVQGRAGDGERARAEAA 1296

Query: 505  QSLQREKQGLEQ---ATTDLRLTILELEREL-----------EELKERERLLVAFPDLHR 550
            + LQR +  LE    A  +     + L +EL           E L+E  R  +A     R
Sbjct: 1297 EKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVR 1356

Query: 551  PTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIR 610
              E +  G R   +E +      +G   +    Q Q ++ R R  +EE G L++     R
Sbjct: 1357 AMEAEAAGLR-EQLEEEAAARERAGR--ELQTAQAQLSEWR-RRQEEEAGALEAGEEARR 1412

Query: 611  EVAQQ 615
              A++
Sbjct: 1413 RAARE 1417



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 94/424 (22%), Positives = 172/424 (40%), Gaps = 63/424 (14%)

Query: 293  LRAQLEEAEGQKDGLRKQA-----------GKLEQALKQEQGARRRQAEEDEQCLSEWEH 341
            L  QL +AE ++D  RKQ            G+LE+ LK +  +  +  EE  + L + + 
Sbjct: 1611 LAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE-LKAQMASAGQGKEEAVKQLRKMQA 1669

Query: 342  DKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQ 401
              ++L  E  + +T    +  + ++  +  + +EA+  +LQEE      A RQ QQ  ++
Sbjct: 1670 QMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDE 1729

Query: 402  VQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSL 461
            +    A   L    +    +Q+     +L++E     S   + E L  + R LL Q++SL
Sbjct: 1730 MADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQS---NSELLNDRYRKLLLQVESL 1786

Query: 462  DQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDL 521
              E    R    +AE+ R ++E Q+              QEL   L  E  G   A    
Sbjct: 1787 TTELSAERSFSAKAESGRQQLERQI--------------QELRGRLGEEDAG---ARARH 1829

Query: 522  RLTILELERELEELKERERLLVAFPDLHRPTETQIHGGR-----SSSVESQITCPTDSGN 576
            ++TI  LE +L + +E+         L + T  +I  G+        ++  +    +   
Sbjct: 1830 KMTIAALESKLAQAEEQ---------LEQETRERILSGKLVRRAEKRLKEVVLQVEEERR 1880

Query: 577  VTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIPQDRLWSPSSKGTQG 636
            V D +  Q++  ++R++ L+ +          + E  ++       + RL       T+ 
Sbjct: 1881 VADQLRDQLEKGNLRVKQLKRQ----------LEEAEEEASRAQAGRRRLQRELEDVTES 1930

Query: 637  ATPPVQAKSTSPGPLGRQHLP-SSRTGRTL------LGQPCTSPPRQPCTSPPRQPCTSP 689
            A    +  +T    L R  L  ++RT R +      +     +   QP + P  +P  SP
Sbjct: 1931 AESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQPGSGPSPEPEGSP 1990

Query: 690  PRQP 693
            P  P
Sbjct: 1991 PAHP 1994



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 90/357 (25%), Positives = 156/357 (43%), Gaps = 48/357 (13%)

Query: 277  AEQRKDLTRLSKHVEALRAQL----EEAEGQKDGLRKQAGKLEQALKQEQGARRR---QA 329
            AEQ +    L    E  R +L    +E E     L  + G+ E+  +Q Q  ++R     
Sbjct: 910  AEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHI 969

Query: 330  EEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELK--QQRESTQAVEAKA--QQLQEEG 385
            +E E  L   E  +Q+L  E    + KM   E +L   + + S  + E K    +L E  
Sbjct: 970  QELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFS 1029

Query: 386  ERRAAAERQVQQLEEQVQQLEAQVQLLVGRL--EGAGQQVCWASTELDKEKARVDSMVRH 443
             + A  E +V+ L +   + EA +  +  RL  E  G+Q      EL+K K R+D     
Sbjct: 1030 SQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQ------ELEKLKRRLD----- 1078

Query: 444  QESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQEL 503
                  +   L +Q+    Q  EELR       AQ  R EE+LQ+   + + +  A+ +L
Sbjct: 1079 -----GESSELQEQMVEQQQRAEELR-------AQLGRKEEELQAALARAEDEGGARAQL 1126

Query: 504  LQSLQREKQGLEQATTDL---RLTILELERELEEL-KERERLLVAFPDLHRPTETQIHGG 559
            L+SL+  +  L +A  DL   R+   + E++  +L +E E L     D    T  Q    
Sbjct: 1127 LKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE-- 1184

Query: 560  RSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQG 616
              S  E ++T       +   +E + + ++  ++ L++ +G+    L++  E A++G
Sbjct: 1185 LRSKREQEVT------ELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG 1235



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 46/194 (23%), Positives = 91/194 (46%), Gaps = 32/194 (16%)

Query: 356  KMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGR 415
            ++ T  + L Q     + ++A+AQ+LQ+                  VQ+L+ Q    VG 
Sbjct: 853  RLFTKVKPLLQVTRQDEVLQARAQELQK------------------VQELQQQSAREVGE 894

Query: 416  LEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEA 475
            L+G   Q       L++E+AR+   +R +  L A+      +L +  QE E +   L+  
Sbjct: 895  LQGRVAQ-------LEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEAR 947

Query: 476  EAQRARVEEQLQSEREQGQCQLRAQQELLQSLQ--REKQGLEQATTDLRL-----TILEL 528
              +      Q+Q+E+++ Q  ++  +  L++ +  R+K  LE+ TT+ ++      +L L
Sbjct: 948  VGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLL 1007

Query: 529  ERELEELKERERLL 542
            E +  +L +  +LL
Sbjct: 1008 EDQNSKLSKERKLL 1021



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 25/88 (28%), Positives = 41/88 (46%), Gaps = 4/88 (4%)

Query: 281  KDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWE 340
            K + R  K ++ +  Q+EE     D LR Q  K    +KQ     +RQ EE E+  S  +
Sbjct: 1859 KLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQ----LKRQLEEAEEEASRAQ 1914

Query: 341  HDKQQLLTETSDLKTKMATLERELKQQR 368
              +++L  E  D+     ++ RE+   R
Sbjct: 1915 AGRRRLQRELEDVTESAESMNREVTTLR 1942



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 31/127 (24%), Positives = 58/127 (45%), Gaps = 17/127 (13%)

Query: 290  VEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTE 349
            +E+  AQ EE   Q+   R  +GKL +  ++       Q EE+ +   +    + QL  E
Sbjct: 1836 LESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQL---RDQL--E 1890

Query: 350  TSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQV 409
              +L+ K   L+R+L++  E     +A  ++LQ          R+++ + E  + +  +V
Sbjct: 1891 KGNLRVKQ--LKRQLEEAEEEASRAQAGRRRLQ----------RELEDVTESAESMNREV 1938

Query: 410  QLLVGRL 416
              L  RL
Sbjct: 1939 TTLRNRL 1945


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 88/362 (24%), Positives = 161/362 (44%), Gaps = 41/362 (11%)

Query: 273  GRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQG-------AR 325
            G W     K    L   V  LRA+L   +  +    ++  +LE  L++ QG       AR
Sbjct: 1278 GAW----EKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERAR 1333

Query: 326  RRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQL-QEE 384
               AE+ ++  +E E+    L    ++ ++K   L +EL     ST+A    AQ+L QEE
Sbjct: 1334 AEAAEKLQRAQAELENVSGAL----NEAESKTIRLSKELS----STEAQLHDAQELLQEE 1385

Query: 385  GERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQ 444
               + A   +V+ +E +   L  Q++      E AG+++  A  +L + + R +      
Sbjct: 1386 TRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGAL 1445

Query: 445  ESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELL 504
            E+ +  +R   ++ ++L Q   E   ++D  E  R R    LQ E +     L  Q++L+
Sbjct: 1446 EAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRR----LQQELDDATMDLEQQRQLV 1501

Query: 505  QSLQREKQGLEQATTDLRLTIL----ELERELEELKERE-------RLLVAFPDLHRPTE 553
             +L+++++  +Q   + +  +L    E ER   E +ERE       R L    +     E
Sbjct: 1502 STLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELE 1561

Query: 554  TQIHGGRSSSVESQITCPTDSGNVTDHMER-----QVQANDIRIRVLQEENGRLQSMLSK 608
             Q    R + +E+ ++   D G     +ER     +  AND+R +V + E+    +  +K
Sbjct: 1562 RQNRALR-AELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAK 1620

Query: 609  IR 610
            +R
Sbjct: 1621 LR 1622



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 80/308 (25%), Positives = 138/308 (44%), Gaps = 44/308 (14%)

Query: 267  LPAATVGRWAAE-QRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQ----- 320
            L +  V R  AE QR+DL    + +EALR +LE+     +  ++   K EQ + +     
Sbjct: 1185 LESERVARTKAEKQRRDL---GEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTL 1241

Query: 321  EQGARRRQAEEDE------QCLSE--------------WEHDKQQLLTETSDLKTKMATL 360
            E+  R  +A   E      Q L E              WE  +  L  E S+L+ ++++L
Sbjct: 1242 EEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL 1301

Query: 361  ERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAG 420
            +   ++  +  + +E    QLQE   R    ER   +  E++Q+ +A+++ + G L  A 
Sbjct: 1302 QTARQEGEQRRRRLEL---QLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAE 1358

Query: 421  QQVCWASTELDKEKARV-DSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQR 479
             +    S EL   +A++ D+    QE  +AK  AL  ++ +++ E   LR  L+E  A R
Sbjct: 1359 SKTIRLSKELSSTEAQLHDAQELLQEETRAK-LALGSRVRAMEAEAAGLREQLEEEAAAR 1417

Query: 480  ARVEEQLQS----------EREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELE 529
             R   +LQ+           +E+    L A +E  +   RE + L Q   +   T+  LE
Sbjct: 1418 ERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLE 1477

Query: 530  RELEELKE 537
            R    L++
Sbjct: 1478 RGRRRLQQ 1485



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 96/375 (25%), Positives = 171/375 (45%), Gaps = 47/375 (12%)

Query: 265  RPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALK-QEQG 323
            R   A ++ R   E+++    L +   ALRA+LE     KD + K   +LE+A +  EQ 
Sbjct: 1539 REARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQA 1598

Query: 324  AR--RRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAK-AQQ 380
            A   R Q  E E  L+  E  K +L      LKT+    ER+L+ + E+ +    + A+Q
Sbjct: 1599 ANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQH---ERDLQGRDEAGEERRRQLAKQ 1655

Query: 381  LQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSM 440
            L++    R    +Q        ++LE +++ L  ++  AGQ          KE+A     
Sbjct: 1656 LRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ---------GKEEA----- 1701

Query: 441  VRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQ 500
            V+    +QA+ + L ++++     REE+     E+E +   +E ++   +E+     RA+
Sbjct: 1702 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1761

Query: 501  QELLQSLQREKQGLEQATTDL-RLTILELEREL--------EELKERERLLVAFPDLHRP 551
            ++  Q   R++   E A  +L +  ILE +R+L        EEL+E +       D +R 
Sbjct: 1762 RQAQQ--DRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRK 1819

Query: 552  TETQIHGGRSS-SVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENG---------- 600
               Q+    +  S E   +   +SG     +ERQ+Q  ++R R+ +E+ G          
Sbjct: 1820 LLLQVESLTTELSAERSFSAKAESGR--QQLERQIQ--ELRGRLGEEDAGARARHKMTIA 1875

Query: 601  RLQSMLSKIREVAQQ 615
             L+S L++  E  +Q
Sbjct: 1876 ALESKLAQAEEQLEQ 1890



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 95/403 (23%), Positives = 167/403 (41%), Gaps = 48/403 (11%)

Query: 241  LCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEA 300
            L + QN  S L + ++L++D +      AA       E+ K L +L    EA  A +E+ 
Sbjct: 1047 LLEDQN--SKLSKERKLLEDRLAEFSSQAAE----EEEKVKSLNKLRLKYEATIADMEDR 1100

Query: 301  EGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATL 360
              +++  R++  KL++ L  E    + Q  E +Q   E    + QL  +  +L+  +A  
Sbjct: 1101 LRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEEL---RAQLGRKEEELQAALARA 1157

Query: 361  ERE-------LKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLV 413
            E E       LK  RE+  A+    + L+ E   R  AE+Q + L E+++ L  +++  +
Sbjct: 1158 EDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTL 1217

Query: 414  GRLEGAGQQVCWASTELDKEKARVDSMVR-----HQESLQAKQRALLKQLDSLDQER--- 465
                   +       E+ + K  ++   R      QE  Q   +AL +  + L+Q R   
Sbjct: 1218 DSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK 1277

Query: 466  ---EELRGSLDEAEAQRARVE-EQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDL 521
               E+ R +L EAE    R E   LQ+ R++G+ + R  +  LQ +Q      E+A  + 
Sbjct: 1278 GAWEKTRLAL-EAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEA 1336

Query: 522  RLTILELERELEE----LKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNV 577
               +   + ELE     L E E   +        TE Q+H               D+  +
Sbjct: 1337 AEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH---------------DAQEL 1381

Query: 578  TDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKL 620
                 R   A   R+R ++ E   L+  L +     ++ G +L
Sbjct: 1382 LQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGREL 1424



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 85/362 (23%), Positives = 152/362 (41%), Gaps = 46/362 (12%)

Query: 277  AEQRKDLTRLSKHVEALRAQLEEA----EGQKD---GLRKQAGKLEQALKQEQGARRRQA 329
            AE+ + + RL +    L+ +L++A    E Q+     L K+  K +Q L +E+ A  R  
Sbjct: 1467 AEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAV 1526

Query: 330  EEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRA 389
            EE E+  +E    + + L+ T  L+ +    E   +Q R     +EA      + G+   
Sbjct: 1527 EERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH 1586

Query: 390  AAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVR-HQESLQ 448
              ER  +  E+    L AQV  L   L  A          +   K + +  ++   E+ +
Sbjct: 1587 ELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGE 1646

Query: 449  AKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQ 508
             ++R L KQL   + ER+E R     A A R ++E +L              +EL   + 
Sbjct: 1647 ERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGEL--------------EELKAQMA 1692

Query: 509  REKQGLEQATTDLR---LTILELERELEELK-ERERLLVAFPDLHRPTETQIHGGRSSSV 564
               QG E+A   LR     + EL RE+EE +  RE +       +R +E ++ G     +
Sbjct: 1693 SAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIF----SQNRESEKRLKG-----L 1743

Query: 565  ESQITCPTDSGNVTDHMERQVQAN-----------DIRIRVLQEENGRLQSMLSKIREVA 613
            E+++    +    +D   RQ Q +           ++    + EE  +L+  L ++ E  
Sbjct: 1744 EAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEEL 1803

Query: 614  QQ 615
            ++
Sbjct: 1804 EE 1805



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 87/365 (23%), Positives = 159/365 (43%), Gaps = 43/365 (11%)

Query: 280  RKDLTRLSKHVEA----LRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQC 335
            R++L +L + ++     L+ Q+ E + + + LR Q G+ E+ L+        +     Q 
Sbjct: 1108 RQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQL 1167

Query: 336  LSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQE-------EGERR 388
            L      +  L     DL+++     +  KQ+R+  + +EA   +L++       + E R
Sbjct: 1168 LKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELR 1227

Query: 389  AAAERQVQQ----LEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQ 444
            +  E++V +    LEE+ +  EA VQ L  R    GQ +   + +L++ +    +  + +
Sbjct: 1228 SKREQEVTELKKTLEEETRIHEAAVQELRQR---HGQALGELAEQLEQARRGKGAWEKTR 1284

Query: 445  ESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELL 504
             +L+A+   L  +L SL   R+       E E +R R+E QLQ  + +     RA+ E  
Sbjct: 1285 LALEAEVSELRAELSSLQTARQ-------EGEQRRRRLELQLQEVQGRAGDGERARAEAA 1337

Query: 505  QSLQREKQGLEQ---ATTDLRLTILELEREL-----------EELKERERLLVAFPDLHR 550
            + LQR +  LE    A  +     + L +EL           E L+E  R  +A     R
Sbjct: 1338 EKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVR 1397

Query: 551  PTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIR 610
              E +  G R   +E +      +G   +    Q Q ++ R R  +EE G L++     R
Sbjct: 1398 AMEAEAAGLR-EQLEEEAAARERAGR--ELQTAQAQLSEWR-RRQEEEAGALEAGEEARR 1453

Query: 611  EVAQQ 615
              A++
Sbjct: 1454 RAARE 1458



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 94/424 (22%), Positives = 172/424 (40%), Gaps = 63/424 (14%)

Query: 293  LRAQLEEAEGQKDGLRKQA-----------GKLEQALKQEQGARRRQAEEDEQCLSEWEH 341
            L  QL +AE ++D  RKQ            G+LE+ LK +  +  +  EE  + L + + 
Sbjct: 1652 LAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE-LKAQMASAGQGKEEAVKQLRKMQA 1710

Query: 342  DKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQ 401
              ++L  E  + +T    +  + ++  +  + +EA+  +LQEE      A RQ QQ  ++
Sbjct: 1711 QMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDE 1770

Query: 402  VQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSL 461
            +    A   L    +    +Q+     +L++E     S   + E L  + R LL Q++SL
Sbjct: 1771 MADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQS---NSELLNDRYRKLLLQVESL 1827

Query: 462  DQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDL 521
              E    R    +AE+ R ++E Q+              QEL   L  E  G   A    
Sbjct: 1828 TTELSAERSFSAKAESGRQQLERQI--------------QELRGRLGEEDAG---ARARH 1870

Query: 522  RLTILELERELEELKERERLLVAFPDLHRPTETQIHGGR-----SSSVESQITCPTDSGN 576
            ++TI  LE +L + +E+         L + T  +I  G+        ++  +    +   
Sbjct: 1871 KMTIAALESKLAQAEEQ---------LEQETRERILSGKLVRRAEKRLKEVVLQVEEERR 1921

Query: 577  VTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIPQDRLWSPSSKGTQG 636
            V D +  Q++  ++R++ L+ +          + E  ++       + RL       T+ 
Sbjct: 1922 VADQLRDQLEKGNLRVKQLKRQ----------LEEAEEEASRAQAGRRRLQRELEDVTES 1971

Query: 637  ATPPVQAKSTSPGPLGRQHLP-SSRTGRTL------LGQPCTSPPRQPCTSPPRQPCTSP 689
            A    +  +T    L R  L  ++RT R +      +     +   QP + P  +P  SP
Sbjct: 1972 AESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQPGSGPSPEPEGSP 2031

Query: 690  PRQP 693
            P  P
Sbjct: 2032 PAHP 2035



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 90/357 (25%), Positives = 156/357 (43%), Gaps = 48/357 (13%)

Query: 277  AEQRKDLTRLSKHVEALRAQL----EEAEGQKDGLRKQAGKLEQALKQEQGARRR---QA 329
            AEQ +    L    E  R +L    +E E     L  + G+ E+  +Q Q  ++R     
Sbjct: 951  AEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHI 1010

Query: 330  EEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELK--QQRESTQAVEAKA--QQLQEEG 385
            +E E  L   E  +Q+L  E    + KM   E +L   + + S  + E K    +L E  
Sbjct: 1011 QELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFS 1070

Query: 386  ERRAAAERQVQQLEEQVQQLEAQVQLLVGRL--EGAGQQVCWASTELDKEKARVDSMVRH 443
             + A  E +V+ L +   + EA +  +  RL  E  G+Q      EL+K K R+D     
Sbjct: 1071 SQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQ------ELEKLKRRLD----- 1119

Query: 444  QESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQEL 503
                  +   L +Q+    Q  EELR       AQ  R EE+LQ+   + + +  A+ +L
Sbjct: 1120 -----GESSELQEQMVEQQQRAEELR-------AQLGRKEEELQAALARAEDEGGARAQL 1167

Query: 504  LQSLQREKQGLEQATTDL---RLTILELERELEEL-KERERLLVAFPDLHRPTETQIHGG 559
            L+SL+  +  L +A  DL   R+   + E++  +L +E E L     D    T  Q    
Sbjct: 1168 LKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE-- 1225

Query: 560  RSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQG 616
              S  E ++T       +   +E + + ++  ++ L++ +G+    L++  E A++G
Sbjct: 1226 LRSKREQEVT------ELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG 1276



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 46/194 (23%), Positives = 91/194 (46%), Gaps = 32/194 (16%)

Query: 356  KMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGR 415
            ++ T  + L Q     + ++A+AQ+LQ+                  VQ+L+ Q    VG 
Sbjct: 894  RLFTKVKPLLQVTRQDEVLQARAQELQK------------------VQELQQQSAREVGE 935

Query: 416  LEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEA 475
            L+G   Q       L++E+AR+   +R +  L A+      +L +  QE E +   L+  
Sbjct: 936  LQGRVAQ-------LEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEAR 988

Query: 476  EAQRARVEEQLQSEREQGQCQLRAQQELLQSLQ--REKQGLEQATTDLRL-----TILEL 528
              +      Q+Q+E+++ Q  ++  +  L++ +  R+K  LE+ TT+ ++      +L L
Sbjct: 989  VGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLL 1048

Query: 529  ERELEELKERERLL 542
            E +  +L +  +LL
Sbjct: 1049 EDQNSKLSKERKLL 1062



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 25/88 (28%), Positives = 41/88 (46%), Gaps = 4/88 (4%)

Query: 281  KDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWE 340
            K + R  K ++ +  Q+EE     D LR Q  K    +KQ     +RQ EE E+  S  +
Sbjct: 1900 KLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQ----LKRQLEEAEEEASRAQ 1955

Query: 341  HDKQQLLTETSDLKTKMATLERELKQQR 368
              +++L  E  D+     ++ RE+   R
Sbjct: 1956 AGRRRLQRELEDVTESAESMNREVTTLR 1983



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 31/127 (24%), Positives = 58/127 (45%), Gaps = 17/127 (13%)

Query: 290  VEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTE 349
            +E+  AQ EE   Q+   R  +GKL +  ++       Q EE+ +   +    + QL  E
Sbjct: 1877 LESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQL---RDQL--E 1931

Query: 350  TSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQV 409
              +L+ K   L+R+L++  E     +A  ++LQ          R+++ + E  + +  +V
Sbjct: 1932 KGNLRVKQ--LKRQLEEAEEEASRAQAGRRRLQ----------RELEDVTESAESMNREV 1979

Query: 410  QLLVGRL 416
              L  RL
Sbjct: 1980 TTLRNRL 1986


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 106/400 (26%), Positives = 184/400 (46%), Gaps = 57/400 (14%)

Query: 255  QQLVQDSMGLRPLPAATVGRWAAEQRKDLT---RLSKHVEALRAQLEEAEGQKDGLRKQA 311
            QQL ++  GL+        R + EQR+D     +L +  +  R  L      ++ LRK+ 
Sbjct: 847  QQLQEEEDGLQEDQER---RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903

Query: 312  GKL---EQALKQEQGARRRQAEEDEQCLSE--WEHDKQQLLTETSDLKTKMATLERELKQ 366
              L   E+ L++E+  +RR+ E++ Q   E   + +++QLL E  + + +    ERE +Q
Sbjct: 904  QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ---ERE-RQ 959

Query: 367  QRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCW- 425
             R+  +  + + Q L EE E+R   ER+ +  EE+  Q E +  L   R +   Q+  W 
Sbjct: 960  YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE--WE 1017

Query: 426  ----ASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRA- 480
                   EL +E+ ++    R +  LQ ++R   ++ + L QE E+L G  +E E +R  
Sbjct: 1018 RQYRKKDELQQEEEQLLREEREKRRLQERERQ-YREEEELQQEEEQLLG--EERETRRRQ 1074

Query: 481  ------RVEEQLQSEREQ-------------GQCQLRAQQELLQSLQREKQGLEQATTDL 521
                  R EE+LQ E EQ              + Q R ++EL    Q E+Q L +     
Sbjct: 1075 ELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEEL---QQEEEQLLREEREKR 1131

Query: 522  RLTILELE-RELEEL-KERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTD 579
            R   LE + RE EE+ +E E+LL   P+  R  E +        ++ +     +   + +
Sbjct: 1132 RRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE-----EEQLLRE 1186

Query: 580  HMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQGGLK 619
              E++ Q  + + R  +EE  + Q    + R+  Q+  LK
Sbjct: 1187 EQEKRRQERERQYR--EEEELQRQKRKQRYRDEDQRSDLK 1224



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 94/366 (25%), Positives = 168/366 (45%), Gaps = 51/366 (13%)

Query: 279  QRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQG------ARRRQAEED 332
            Q ++  +LS+     + +LEE + ++    ++  + EQ L++++G       R R+  ED
Sbjct: 1565 QEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRED 1624

Query: 333  EQCLSEWEHDKQQLLTETSDLK-----TKMATLERELKQQRESTQAVEAKAQQLQEEGE- 386
            EQ L   E ++QQL  +  D K      ++   ERE +Q R        + +QL +EGE 
Sbjct: 1625 EQLLQ--EREEQQLHRQERDRKFLEEEPQLRRQERE-QQLRHDRDRKFREEEQLLQEGEE 1681

Query: 387  ---RRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVR- 442
               RR   +R+ ++ E+Q+++ E + + L    +   Q++        + K R +  +R 
Sbjct: 1682 QQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQEL--------ERKFREEEQLRQ 1733

Query: 443  --HQESL--QAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQC--- 495
               QE L  Q + R +L++ + L  EREE +    E + ++ R EEQL+ ERE+ Q    
Sbjct: 1734 ETEQEQLRRQERYRKILEE-EQLRPEREEQQLRRQERD-RKFREEEQLRQEREEQQLRSQ 1791

Query: 496  ----QLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRP 551
                + R +++L Q  +RE+Q L     D +      E E  +L+E+E+ L    D    
Sbjct: 1792 ESDRKFREEEQLRQ--EREEQQLRPQQRDGK---YRWEEEQLQLEEQEQRLRQERDRQYR 1846

Query: 552  TETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIRE 611
             E Q      S  E Q     +        ER+++   IR +  +E+  R      ++ E
Sbjct: 1847 AEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHR------QVGE 1900

Query: 612  VAQQGG 617
            +  Q G
Sbjct: 1901 IKSQEG 1906



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 75/280 (26%), Positives = 133/280 (47%), Gaps = 15/280 (5%)

Query: 278 EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARR-RQAEEDEQCL 336
           E+R+   R  +  E    QL   +  +   R+Q  + EQ L++EQ  RR +Q   ++Q  
Sbjct: 358 ERREQQLRREQEEERREQQLRREQQLR---REQQLRREQQLRREQQLRREQQLRREQQLR 414

Query: 337 SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQ 396
            E +  ++Q L    + +      E+E ++QR   +  E +    +EE   R   ER+ Q
Sbjct: 415 REQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQ 474

Query: 397 QLEEQVQQLEAQVQLLVGRLEGAGQQV-CWASTELDKEKARVDSMVRHQESLQAKQRALL 455
           QL+   ++   +  L +   E   QQ         ++E+ R   + R +E  + +QR   
Sbjct: 475 QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRS 534

Query: 456 KQLDSLDQE--REELRGSLDEAEAQRARVEEQLQSEREQGQCQL--RAQQELLQSLQRE- 510
           +Q    +QE  RE+L    +E   ++ R E++L+ E+E+ + QL  R ++   Q L+RE 
Sbjct: 535 EQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQ 594

Query: 511 KQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHR 550
           ++ LEQ     RL   E+ER  +E +  +RL    P+  R
Sbjct: 595 EERLEQ-----RLKREEVERLEQEERREQRLKREEPEEER 629



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 91/384 (23%), Positives = 164/384 (42%), Gaps = 64/384 (16%)

Query: 274 RWAA-EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEED 332
           RW   E+ +   +  +  + LR + EE   Q+   +++  +L+Q L+ EQ  RR Q E  
Sbjct: 487 RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERR 546

Query: 333 EQCLS-------EWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQ-EE 384
           EQ L        E E  +Q+L  E  + + ++   E E +QQR   +  E   Q+L+ EE
Sbjct: 547 EQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606

Query: 385 GERRAAAERQVQQL--------------------EEQVQQLEAQVQLLVGRLEGAGQQVC 424
            ER    ER+ Q+L                    E + QQL  + Q      E   Q++ 
Sbjct: 607 VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ------ERREQRL- 659

Query: 425 WASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSL--------DEAE 476
               + ++E+ R++  ++ +   + +++ L +  +  +Q RE ++  +         EA+
Sbjct: 660 ----KREEEEERLEQRLKREHEEERREQELAE--EEQEQARERIKSRIPKWQWQLESEAD 713

Query: 477 AQRARV----EEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELEREL 532
           A++++V     +Q    R Q Q + R ++E     Q E++   Q   + +      + + 
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA 773

Query: 533 EELKERER-LLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIR 591
           EE  ER R  L A P L    E Q+        E +     +     +   RQ +  +  
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEE---KEQRRRQRREREKE 830

Query: 592 IRVLQEENGRLQSMLSKIREVAQQ 615
           ++ L+EE  +LQ      RE AQQ
Sbjct: 831 LQFLEEEE-QLQR-----RERAQQ 848



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 72/271 (26%), Positives = 133/271 (49%), Gaps = 31/271 (11%)

Query: 278 EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAE---EDEQ 334
           EQ +   RL +  E  R  L+  E  +   R +  + +Q LK++Q   RR+     E+E+
Sbjct: 439 EQERREQRLKREQEERRDWLKREEETE---RHEQERRKQQLKRDQEEERRERWLKLEEEE 495

Query: 335 CLSEWEHDKQQLLTETSDLKTKMATLERELKQQRES---TQAVEAKAQQLQEEGERRAAA 391
              + E  +QQL  E  + +      E+ LK+Q E     Q + ++ Q  +E+ ERR   
Sbjct: 496 RREQQERREQQLRREQEERR------EQRLKRQEEEERLQQRLRSEQQLRREQEERR--- 546

Query: 392 ERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ 451
           E+ +++ EE+  + E + Q L    E    Q+      L +E+ R    ++ ++  + +Q
Sbjct: 547 EQLLKREEEKRLEQERREQRLKREQEERRDQL------LKREEERRQQRLKREQEERLEQ 600

Query: 452 RALLKQLDSLDQ-EREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQRE 510
           R   ++++ L+Q ER E R   +E E +R +   + + + E+ Q QLR +Q+     +R 
Sbjct: 601 RLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ-----ERR 655

Query: 511 KQGLEQATTDLRLTILELERELEELKERERL 541
           +Q L++   + RL    L+RE EE +  + L
Sbjct: 656 EQRLKREEEEERLE-QRLKREHEEERREQEL 685



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 77/332 (23%), Positives = 144/332 (43%), Gaps = 23/332 (6%)

Query: 298 EEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKM 357
           EE   +++ L+   G   +    E+  RRR+  E  +   +   +KQQ   E  D   + 
Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRR---KGREEKQQQRRERQDRVFQ- 239

Query: 358 ATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLE 417
              E E K+ R+    +  + ++LQEE  +R   +R++Q+ EEQ+++LE Q      + E
Sbjct: 240 ---EEEEKEWRKRETVLRKEEEKLQEEEPQR---QRELQEEEEQLRKLERQELRRERQEE 293

Query: 418 GAGQQVCWASTELDK--EKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEA 475
              QQ      +L +  E+ R +     +E  + +++   ++   L +E+EE R      
Sbjct: 294 EQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRR 353

Query: 476 EAQRARVEEQL--QSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELE 533
           E +  R E+QL  + E E+ + QLR +Q+L +  Q  ++   +    LR    E +   E
Sbjct: 354 EQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLR---REQQLRRE 410

Query: 534 ELKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIR 593
           +   RE+ L     L R  E + H  +      +     +     D ++R+ +       
Sbjct: 411 QQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE----- 465

Query: 594 VLQEENGRLQSMLSKIREVAQQGGLKLIPQDR 625
              E+  R Q +     E  ++  LKL  ++R
Sbjct: 466 -RHEQERRKQQLKRDQEEERRERWLKLEEEER 496



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 62/274 (22%), Positives = 133/274 (48%), Gaps = 14/274 (5%)

Query: 243 QSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEG 302
           + + L S  G   +   D   LR      + R   E+++   R  +       + +E   
Sbjct: 189 EEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRK 248

Query: 303 QKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLER 362
           ++  LRK+    E+ L++E+  R+R+ +E+E+ L + E  +Q+L  E  + + +   L R
Sbjct: 249 RETVLRKE----EEKLQEEEPQRQRELQEEEEQLRKLE--RQELRRERQEEEQQQQRLRR 302

Query: 363 ELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQ 422
           E + +R+  +    + ++ +E+ ERR   E + +Q   + Q+   + QL   + E   +Q
Sbjct: 303 EQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQ 362

Query: 423 VCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQE---REELRGSLDEAEAQR 479
                   ++E+ R +  +R ++ L+ +Q+   +Q    +Q+    ++LR        Q+
Sbjct: 363 ----QLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 418

Query: 480 ARVEEQLQSEREQGQCQLRAQQELL-QSLQREKQ 512
            R E+QL+ E+E+ + + + +QE   Q L+RE++
Sbjct: 419 LRREQQLRREQEEERHEQKHEQERREQRLKREQE 452



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 82/336 (24%), Positives = 149/336 (44%), Gaps = 23/336 (6%)

Query: 280  RKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEW 339
            R++  +LS+     + + EE + ++    ++  + EQ L+QE   R R+  E+EQ L E 
Sbjct: 1417 REEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQE---RHRKFREEEQLLQER 1473

Query: 340  EHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLE 399
            E  +QQL  +  D K     LE E +Q R   +  + + Q+L+ +   R   E + Q   
Sbjct: 1474 E--EQQLHRQERDRKF----LEEE-QQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR 1526

Query: 400  EQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLD 459
            +Q Q+   Q +  + R E   Q+      +  +E+         Q S Q + R    +  
Sbjct: 1527 QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQ 1586

Query: 460  SLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATT 519
             + ++ +E +   DE + +R   ++QL+ ER++   + R  ++LLQ  +RE+Q L +   
Sbjct: 1587 KVRRQEQERKFMEDEQQLRRQEGQQQLRQERDR---KFREDEQLLQ--EREEQQLHRQER 1641

Query: 520  DLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTD 579
            D +   LE E +L   +  ++L        R  E  +  G    +  Q     +      
Sbjct: 1642 DRK--FLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQ-----ERDRKFR 1694

Query: 580  HMERQVQANDIRIRVLQEENG-RLQSMLSKIREVAQ 614
              E+Q++  +   + LQEE   R Q +  K RE  Q
Sbjct: 1695 EEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQ 1730



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 64/266 (24%), Positives = 136/266 (51%), Gaps = 18/266 (6%)

Query: 278 EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLS 337
           E+R++  +L +  E  R Q    E +++   +Q  + ++  ++EQ  RR Q    EQ L 
Sbjct: 332 EERRE-QQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390

Query: 338 EWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQ 397
                +QQL  E    + +    E++L+++++  +  + + +Q +E  E++   ER+ Q+
Sbjct: 391 R----EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQR 446

Query: 398 L----EEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRA 453
           L    EE+   L+ + +      E   QQ+     + D+E+ R +  ++ +E  + +Q+ 
Sbjct: 447 LKREQEERRDWLKREEETERHEQERRKQQL-----KRDQEEERRERWLKLEEEERREQQE 501

Query: 454 LLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQG 513
             +Q   L +E+EE R    + + +  R++++L+SE++  + Q   +++LL+  + E++ 
Sbjct: 502 RREQ--QLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK--REEEKR 557

Query: 514 LEQATTDLRLTILELERELEELKERE 539
           LEQ   + RL   + ER  + LK  E
Sbjct: 558 LEQERREQRLKREQEERRDQLLKREE 583



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 68/242 (28%), Positives = 118/242 (48%), Gaps = 34/242 (14%)

Query: 315 EQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAV 374
           ++ L++E G RRRQ  ++++          + L E  +   K   LE+  +Q+R+  + +
Sbjct: 126 DRQLEEEPGQRRRQKRQEQE----------RELAEGEEQSEKQERLEQRDRQRRD--EEL 173

Query: 375 EAKAQQLQEEGERRAAAERQVQQL----------EEQVQQLEAQVQLLVGRLEGAGQ--- 421
             + Q+ QE  ERR A E Q+Q            EEQ+++ E       GR E   Q   
Sbjct: 174 WRQRQEWQEREERR-AEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRE 232

Query: 422 -QVCWASTELDKEKARVDSMVR-HQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQR 479
            Q      E +KE  + ++++R  +E LQ ++    ++L    QE EE    L+  E +R
Sbjct: 233 RQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQREL----QEEEEQLRKLERQELRR 288

Query: 480 ARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILE--LERELEELKE 537
            R EE+ Q +R + + QLR +QE  +  Q+E++  +Q   + +    E  L RE EE +E
Sbjct: 289 ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERRE 348

Query: 538 RE 539
           ++
Sbjct: 349 QQ 350



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 73/296 (24%), Positives = 136/296 (45%), Gaps = 39/296 (13%)

Query: 278 EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLS 337
           E+R+   +  +  E  R QL ++E Q++  R+Q  + EQ  ++EQ  +R + EE  +   
Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQEER-RQQQLRREQQERREQRLKREEEEERLEQRL 672

Query: 338 EWEHDKQQLLTETSD---------LKTKMATLERELKQQRESTQA---------VEAKAQ 379
           + EH++++   E ++         +K+++   + +L+ + ++ Q+            + +
Sbjct: 673 KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRR 732

Query: 380 QLQEEGERRAAAERQVQ-------QLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDK 432
           Q QEE  RR  +E Q Q       Q +E+ Q+ +   Q         G+Q   A   L +
Sbjct: 733 QEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLRE 792

Query: 433 EKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQ 492
           ++ R    +R +E  Q +QR L +     ++E+E+ R    E E +   +EE+ Q +R +
Sbjct: 793 QRER---QLRAEERQQREQRFLPE-----EEEKEQRRRQRREREKELQFLEEEEQLQRRE 844

Query: 493 GQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDL 548
              QL+ +++ LQ  Q  ++  EQ         LE     EE K R   L A P L
Sbjct: 845 RAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLE-----EERKRRRHTLYAKPAL 895



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 86/378 (22%), Positives = 155/378 (41%), Gaps = 40/378 (10%)

Query: 274  RWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDE 333
            +W  E   D  R SK     R Q  +   Q+   +++  + E   ++E+ A R+Q EE++
Sbjct: 705  QWQLESEAD-ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQ 763

Query: 334  QCLSEW--------EHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEG 385
            +    W        E  +Q+L       + +   L  E +QQRE     E + ++ +   
Sbjct: 764  RRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQ 823

Query: 386  ERRAAAERQVQQLEEQVQQLEAQVQLLV-------------GRLEGAGQQVCWASTELDK 432
             R    E Q  + EEQ+Q+ E   QL                + +   Q+  W   +L++
Sbjct: 824  RREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRW---QLEE 880

Query: 433  EKAR----VDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQS 488
            E+ R    + +    QE L+ +Q+ L ++ + L +E  E R    + + ++ R EEQLQ 
Sbjct: 881  ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRR--QEQERQYREEEQLQQ 938

Query: 489  EREQGQCQLRAQQELLQSLQREKQ-GLEQATTDLRLTILELERELEELKERERLLVAFPD 547
            E EQ    LR ++E  +  +RE+Q   ++        +L  E E    +ERE+      +
Sbjct: 939  EEEQ---LLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEE 995

Query: 548  LHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLS 607
            L +  E  +   R      +        +     E Q+   +   R LQE   + +    
Sbjct: 996  LQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYRE--- 1052

Query: 608  KIREVAQQGGLKLIPQDR 625
               E  QQ   +L+ ++R
Sbjct: 1053 --EEELQQEEEQLLGEER 1068



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 67/280 (23%), Positives = 124/280 (44%), Gaps = 26/280 (9%)

Query: 279  QRKDLTRLSKHVEALRAQ-----LEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDE 333
            +R++L R  +  E L+ +      EE E ++    +Q  + E+  +Q++  R R  ++  
Sbjct: 1162 RRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221

Query: 334  QCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQ-----LQEEGERR 388
                +WE +K+  +    D K      E E  +Q E +Q  + ++QQ     L E+ ER 
Sbjct: 1222 DLKWQWEPEKENAVR---DNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERD 1278

Query: 389  AAAERQVQQLEE----QVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKAR---VDSMV 441
               ER+  Q  +    + +QLE + Q    R +   Q+      E  +EK R    D   
Sbjct: 1279 REQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKF 1338

Query: 442  RHQESL--QAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRA 499
            R +E L  + +++ L +Q        EELR      E  R  +EE+ +  R++ + +   
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELR----HQEQGRKFLEEEQRLRRQERERKFLK 1394

Query: 500  QQELLQSLQREKQGLEQATTDLRLTILELERELEELKERE 539
            +++ L+  +RE+Q  +      R    +L R+  + K RE
Sbjct: 1395 EEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFRE 1434



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 91/400 (22%), Positives = 162/400 (40%), Gaps = 82/400 (20%)

Query: 279  QRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQA--------- 329
            Q+++   L +  E  R Q  E + +++   +Q  + EQ L++E+  RRRQ          
Sbjct: 1087 QQEEEQLLREEPEKRRRQERERQCREEEELQQ--EEEQLLREEREKRRRQELERQYREEE 1144

Query: 330  ---EEDEQCL-------------------SEWEHDKQQLLTETSDLKTKMATLERELKQQ 367
               +E+EQ L                    E + +++QLL E  + + +    ERE + +
Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ----ERERQYR 1200

Query: 368  RESTQAVEAKAQQLQEEGER----------------------RAAAERQVQQLEEQVQQL 405
             E     + + Q+ ++E +R                      +     Q +QLE+  Q  
Sbjct: 1201 EEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDS-QLR 1259

Query: 406  EAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRH---QESLQAKQRALLKQLDSLD 462
            + Q Q  +  L G  Q+      + ++E+ R     RH   +E L+ +++   K+ D   
Sbjct: 1260 DRQSQQDLQHLLGEQQE-----RDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKS 1314

Query: 463  QEREELRGSLDEAEAQRA------RVEEQLQSEREQG--QCQLRAQQELLQSLQREKQGL 514
            QE ++L     E + +R       R EEQL  ERE+   + Q R ++   + L+ ++QG 
Sbjct: 1315 QEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGR 1374

Query: 515  EQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDS 574
            +    + RL     ERE + LKE ++L        R  + +    R    E Q     + 
Sbjct: 1375 KFLEEEQRLR--RQERERKFLKEEQQLRCQ----EREQQLRQDRDRKFREEEQQLSRQER 1428

Query: 575  GNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQ 614
                   E+QV+  +   + L+EE    Q    K RE  Q
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ 1468



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 69/277 (24%), Positives = 116/277 (41%), Gaps = 56/277 (20%)

Query: 278  EQRKDLTRLSK----HVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDE 333
            E++K+  R  +      + LR + EE                   K+ +    R+  E+E
Sbjct: 1302 EEQKEAKRRDRKSQEEKQLLREEREE-------------------KRRRQETDRKFREEE 1342

Query: 334  QCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAER 393
            Q L   E ++Q L  +  D K +    E EL+ Q +  + +E + +  ++E ER+   E 
Sbjct: 1343 QLLQ--EREEQPLRRQERDRKFR----EEELRHQEQGRKFLEEEQRLRRQERERKFLKEE 1396

Query: 394  QVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRA 453
            Q  + +E+ QQL    Q    +     QQ+  +  E D++    +  VR QE    ++R 
Sbjct: 1397 QQLRCQEREQQLR---QDRDRKFREEEQQL--SRQERDRKFREEEQQVRRQE----RERK 1447

Query: 454  LLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQG 513
             L++   L QER            ++ R EEQL  ERE+ Q     +QE  +    E+Q 
Sbjct: 1448 FLEEEQQLRQERH-----------RKFREEEQLLQEREEQQLH---RQERDRKFLEEEQQ 1493

Query: 514  LEQATTDLRLTILELERELEELKERERLLVAFPDLHR 550
            L +   D +      E+EL   +   + L     LHR
Sbjct: 1494 LRRQERDRKFR----EQELRSQEPERKFLEEEQQLHR 1526



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 50/202 (24%), Positives = 96/202 (47%), Gaps = 26/202 (12%)

Query: 365 KQQRESTQAVEAKAQQLQEEGERRAAAERQVQ--QLEEQVQQLEAQVQLLVGRLEGAGQQ 422
           ++Q E  +  E + +QL+EE  +R   +RQ Q  +L E  +Q E Q +L     +   ++
Sbjct: 113 RRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEE 172

Query: 423 VC-----WASTELDK-EKARVDSMVRHQ-----ESLQAKQRALL----KQLDSLDQEREE 467
           +      W   E  + E+ ++ S   H+     +  Q ++R LL    K  +   Q+R E
Sbjct: 173 LWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRE 232

Query: 468 LRGSLDEAEAQR---------ARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQAT 518
            +  + + E ++          + EE+LQ E  Q Q +L+ ++E L+ L+R++   E+  
Sbjct: 233 RQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQE 292

Query: 519 TDLRLTILELERELEELKERER 540
            + +   L  E++L   +E ER
Sbjct: 293 EEQQQQRLRREQQLRRKQEEER 314



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 53/229 (23%), Positives = 99/229 (43%), Gaps = 20/229 (8%)

Query: 279  QRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQAL--KQEQGARR----RQAEED 332
            +R++L R  +  E LR + E+ + ++    ++  + EQ    ++EQ  RR    R+  E+
Sbjct: 1717 RRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREE 1776

Query: 333  EQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAE 392
            EQ     E ++QQL ++ SD K +    E +L+Q+RE  Q    +        E +   E
Sbjct: 1777 EQL--RQEREEQQLRSQESDRKFRE---EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLE 1831

Query: 393  RQVQQL-EEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ 451
             Q Q+L +E+ +Q  A+ Q          +Q  W   E  + + R   +       Q K+
Sbjct: 1832 EQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKE 1891

Query: 452  RALLKQLDSLDQEREELRGSLDE--------AEAQRARVEEQLQSEREQ 492
                +Q+  +  +  +  G L E           + + + E +Q +R Q
Sbjct: 1892 EQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQRSQ 1940



 Score = 30.0 bits (66), Expect = 8.2
 Identities = 35/116 (30%), Positives = 54/116 (46%), Gaps = 26/116 (22%)

Query: 427 STELDKEK-ARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQ 485
           +T LD+EK AR D           K+  L  +    DQ R E R    E E  + R +++
Sbjct: 92  ATGLDEEKRARCDG----------KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKR 141

Query: 486 LQSERE--QGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERE 539
            + ERE  +G+ Q   Q+ L    QR++Q  ++          EL R+ +E +ERE
Sbjct: 142 QEQERELAEGEEQSEKQERL---EQRDRQRRDE----------ELWRQRQEWQERE 184


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 70/296 (23%), Positives = 142/296 (47%), Gaps = 27/296 (9%)

Query: 280  RKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEW 339
            +++L RLS  VEALR QL         L++Q    +  L+ E    ++  E+  + L+E 
Sbjct: 1651 QEELRRLSSEVEALRRQL---------LQEQESVKQAHLRNEHF--QKAIEDKSRSLNES 1699

Query: 340  EHDKQQLLTETSDLKTKMATLERELKQ--------QRESTQAVEAKAQQLQEEGERRAAA 391
            + + ++L + T +L  +   LE EL+         +R  ++A   K   + E   +   +
Sbjct: 1700 KIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQIS 1759

Query: 392  ERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQ 451
              +  +L+  +  L+ + + L   +E   +Q   AS  + + K +   +V+ +ESL  K 
Sbjct: 1760 NNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKI 1819

Query: 452  RALLK---QLDSLDQEREELRGSLDEAEAQRARVE---EQLQSEREQGQCQLRAQQELLQ 505
            + L +   +L  L+ E    + +L+     + R+E   +Q+Q++  Q + Q   ++E ++
Sbjct: 1820 KVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIR 1879

Query: 506  SLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRS 561
             ++ E++  E+    LR  I  L+ E++ ++ER R      D  R T++Q+   RS
Sbjct: 1880 KIESEREKSEREKNSLRSEIERLQAEIKRIEERCRR--KLEDSTRETQSQLETERS 1933



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 67/274 (24%), Positives = 129/274 (47%), Gaps = 21/274 (7%)

Query: 281  KDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGK---LEQALKQEQGARRRQAEEDEQCLS 337
            +D+TR    ++ L+ Q ++ E + + L++ A +     + L++E    RR  +E    ++
Sbjct: 1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKIT 1613

Query: 338  EWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQ 397
                +  Q L + S +K +    E +L+QQR+       + Q+ QEE  R ++   +V+ 
Sbjct: 1614 ----NLTQQLEQASIVKKRS---EDDLRQQRDVLDGHLREKQRTQEELRRLSS---EVEA 1663

Query: 398  LEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQ 457
            L  Q+ Q +  V+    R E   + +   S  L++ K  ++ +    E+L  +   L ++
Sbjct: 1664 LRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEE 1723

Query: 458  LDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQA 517
            L +L  E ++LR    EA++ +     +L+S+ +    +    Q L+  LQRE++ L Q 
Sbjct: 1724 LRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQE 1783

Query: 518  TTDLRLTILELERELEELK--------ERERLLV 543
                +   LE    ++E K        ERE LLV
Sbjct: 1784 IEKFQKQALEASNRIQESKNQCTQVVQERESLLV 1817



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 79/373 (21%), Positives = 145/373 (38%), Gaps = 63/373 (16%)

Query: 293  LRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAE---EDEQCLSEWEHDKQQLLTE 349
            LR QL+    +   L+ +  +L  ++ Q    RRR  E   + + C SE    KQ L  E
Sbjct: 1235 LRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIE 1294

Query: 350  TSDLKTKMA--------TLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQL--- 398
               +  + +        +LE   K  ++  + +E    + QEE +RR   E ++ ++   
Sbjct: 1295 LKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNN 1354

Query: 399  -EEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQ 457
             +E++  L+ Q +                 TE++  K  +  +   +E   +  RA +  
Sbjct: 1355 YDEEIISLKNQFE-----------------TEINITKTTIHQLTMQKEEDTSGYRAQIDN 1397

Query: 458  LD----SLDQEREELRGSLDEAEAQRARVEEQLQSEREQG-QCQLRAQQ------ELLQS 506
            L     SL +E + L+ +L +      RVEE +Q ++  G +   R QQ      ++ Q 
Sbjct: 1398 LTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQM 1457

Query: 507  LQREKQGLEQATTDLRLTILELERELEELK---------------ERERLLVAFPDLHRP 551
               E    +Q+  D   TI +  +E+E LK               E  RL     DL + 
Sbjct: 1458 RTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKA 1517

Query: 552  TETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDI-----RIRVLQEENGRLQSML 606
              +         V+ Q              ER V+  DI      ++ LQ +  +++  L
Sbjct: 1518 NSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEEL 1577

Query: 607  SKIREVAQQGGLK 619
            ++++  A +   K
Sbjct: 1578 NRLKRTASEDSCK 1590



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 64/264 (24%), Positives = 114/264 (43%), Gaps = 41/264 (15%)

Query: 291  EALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTET 350
            ++ +  L++  GQ   L ++  +L   ++ E+  RRR++ ED     + ++D+ Q   + 
Sbjct: 1091 KSAKQNLDKCYGQIKELNEKITRLTYEIEDEK--RRRKSVEDRFDQQKNDYDQLQKARQC 1148

Query: 351  SDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQ 410
                     LE E K  +E    +E     LQEEG R+   E ++ ++     +   ++ 
Sbjct: 1149 EKENLGWQKLESE-KAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNE---EMS 1204

Query: 411  LLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRG 470
             L  + E          TE++  K  +  +   +E      + L  QLD L +E  +L+ 
Sbjct: 1205 NLRNKYE----------TEINITKTTIKEISMQKED---DSKNLRNQLDRLSRENRDLKD 1251

Query: 471  -------SLDEAEAQRARVEEQLQSEREQGQCQLRAQQ----ELLQSLQ-------REKQ 512
                   S+ +A  QR R EE    ++  G   ++ +Q    EL Q +Q       R KQ
Sbjct: 1252 EIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQ 1311

Query: 513  GLEQATTDLRLTILELERELEELK 536
             LE+A      TI +  +E+E LK
Sbjct: 1312 SLEEAAK----TIQDKNKEIERLK 1331



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 57/314 (18%), Positives = 122/314 (38%), Gaps = 64/314 (20%)

Query: 278  EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEED----- 332
            E  K +   +K +E L+A+ +E   ++     +  K+     +E  + + Q E +     
Sbjct: 1315 EAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITK 1374

Query: 333  ----------EQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQ 382
                      E+  S +      L  E   L  ++  L+  L Q  E+ + VE   QQ +
Sbjct: 1375 TTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK 1434

Query: 383  EEGERRAAAERQVQQLEEQVQQLEAQVQLLVGR-LEGAGQQVCWASTELDKEKARVDS-- 439
              G   +  ++Q++    QV Q+  +  +   + L+ A + +   + E+++ K  +D   
Sbjct: 1435 ATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET 1494

Query: 440  ------------MVRHQESLQAKQRALLKQLDSLDQEREEL------------------- 468
                        + R Q  LQ    +  + ++ L  + +EL                   
Sbjct: 1495 NDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQ 1554

Query: 469  -----RGSLDEAEAQRARVEEQ---LQSEREQGQCQLRAQQELLQSLQREKQGLEQATTD 520
                 + SL E + Q+ +VEE+   L+    +  C+ +        L+ E +G+ ++  +
Sbjct: 1555 DITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRK-------KLEEELEGMRRSLKE 1607

Query: 521  LRLTILELERELEE 534
              + I  L ++LE+
Sbjct: 1608 QAIKITNLTQQLEQ 1621



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 53/248 (21%), Positives = 101/248 (40%), Gaps = 44/248 (17%)

Query: 273  GRWAAEQRKDLTRLSKHVEALRAQLEEAEGQK---DGLRKQAGKLEQALKQEQGARRRQA 329
            GR  A+  K+ T L      LR+QL+ +  +     GL     +  + L+QE    ++QA
Sbjct: 1737 GRSEADSDKNATILE-----LRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQA 1791

Query: 330  EEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRA 389
             E    + E ++   Q++ E   L  K+  LE++  + +     +      L+ E   + 
Sbjct: 1792 LEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQ 1851

Query: 390  AAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQA 449
              E + QQ++  + Q + Q                          +R +  +R  ES + 
Sbjct: 1852 RLECEKQQIQNDLNQWKTQY-------------------------SRKEEAIRKIESERE 1886

Query: 450  KQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQS-LQ 508
            K           ++E+  LR  ++  +A+  R+EE+ + + E    + ++Q E  +S  Q
Sbjct: 1887 KS----------EREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQ 1936

Query: 509  REKQGLEQ 516
            RE   L Q
Sbjct: 1937 REIDKLRQ 1944



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 53/295 (17%), Positives = 123/295 (41%), Gaps = 43/295 (14%)

Query: 345  QLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQ 404
            +LLT + D    ++ + + L+  +     +E   ++L+   +  +    + + L++ +Q+
Sbjct: 1005 ELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQK 1064

Query: 405  LEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQE 464
             +A+      +L         AS E  K +A +D      +S +        Q+  L+++
Sbjct: 1065 YQAECSQFKAKL---------ASLEELKRQAELDG-----KSAKQNLDKCYGQIKELNEK 1110

Query: 465  REELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLT 524
               L   +++ + +R  VE++   ++           +L ++ Q EK+ L     +    
Sbjct: 1111 ITRLTYEIEDEKRRRKSVEDRFDQQKND-------YDQLQKARQCEKENLGWQKLESEKA 1163

Query: 525  ILELERELEEL-------------------KERERLLVAFPDLHRPTETQIHGGRSSSVE 565
            I E E E+E L                   K R        +L    ET+I+  +++  E
Sbjct: 1164 IKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKE 1223

Query: 566  SQITCPTDSGNVTDHMERQVQAN-DIRIRVLQEENGRLQSMLSKIREVAQQGGLK 619
              +    DS N+ + ++R  + N D++  +++  +  LQ+  ++ R  A++  L+
Sbjct: 1224 ISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQA--TEQRRRAEENALQ 1276



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 40/192 (20%), Positives = 86/192 (44%), Gaps = 16/192 (8%)

Query: 355 TKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVG 414
           T+   L+    Q  +  + +++  +++++ G+   A ++++ QL+EQ++ L   + +   
Sbjct: 102 TRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRV 161

Query: 415 R---LEGAGQQVCWASTELDKEKARVDSMV---RHQESLQAKQRALLKQLDSLDQEREEL 468
           R    +G G   C + +  D+    V S       Q+  +    A    L S++Q     
Sbjct: 162 RRASSKGGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSH 221

Query: 469 RG---SLDEAEAQRARVEEQLQSE------REQGQCQLRAQQELLQSLQREKQGLEQATT 519
           RG   S+ +   Q  +++  L+ +       E+ +  L+A  E +  L R+ Q + QAT+
Sbjct: 222 RGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHL-RQLQNIIQATS 280

Query: 520 DLRLTILELERE 531
              + I + E E
Sbjct: 281 REIMWINDCEEE 292


>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
          Length = 1139

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 69/274 (25%), Positives = 136/274 (49%), Gaps = 43/274 (15%)

Query: 277 AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
           AE +  L  L KH    + QLE+ +  K  +++Q   L++ LK+ +   +   E  E+ +
Sbjct: 105 AEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYM 160

Query: 337 SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQ 396
            E        + +T+D   +MATL++E+ ++R         A+ LQ+E          V+
Sbjct: 161 EE--------MADTAD-AIEMATLDKEMAEER---------AESLQQE----------VE 192

Query: 397 QLEEQVQQLEAQVQLLVGRLEGAGQQVCWAS---TELDKEKARV-DSMVRHQESLQAKQR 452
            L+E+V +L   +++L   +E  G     +S    +L+++ AR+ D++VR ++   ++++
Sbjct: 193 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 252

Query: 453 ---ALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQR 509
               L K ++  +QE E +R   +  + + ++ E  +   +EQ    L A +E+++ L  
Sbjct: 253 EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA-EEMVEMLTD 311

Query: 510 EKQGLEQATTDLRLTILELERELE---ELKERER 540
               LE+   +LR T+ +LE   E   EL+E  R
Sbjct: 312 RNLNLEEKVRELRETVGDLEAMNEMNDELQENAR 345



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 91/449 (20%), Positives = 183/449 (40%), Gaps = 78/449 (17%)

Query: 139 PQKGANQRETPTSKPTTKGEPARSPEYLTTKLIKPSSPVLGLPQTCQEPESIPVRA-SLQ 197
           P   A+  E  +S+P+T  +   +   + T ++     V  LP   +E E +  +   L+
Sbjct: 35  PSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLE 94

Query: 198 FPATTFKNTRSVHSQTIETALVPCDACASVQGSLQKVGKVVISLCQSQNLPSSLGQFQQL 257
               T +  R                 A  +  L+++ K  I L Q Q   S +      
Sbjct: 95  EKLETLRLKR-----------------AEDKAKLKELEKHKIQLEQVQEWKSKM------ 131

Query: 258 VQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHV-EALRAQLEEAEGQKDGLRKQAGKLEQ 316
                               EQ+ DL R  K   +  +  LE  E   + +   A  +E 
Sbjct: 132 -------------------QEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEM 172

Query: 317 ALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEA 376
           A   ++      AEE  + L   + + + L     +L T +  L+ E++++     A   
Sbjct: 173 ATLDKE-----MAEERAESL---QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY 224

Query: 377 KAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGR----LEGAGQQ-------VCW 425
           + +QL+E+  R   A  +++ L    +Q   ++Q L+ +    LE   QQ       +  
Sbjct: 225 QLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQ 284

Query: 426 ASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQ 485
           A + +D+ K +VD+ +  +E ++     L  +  +L+++  ELR ++ + EA    + ++
Sbjct: 285 AESTIDELKEQVDAALGAEEMVE----MLTDRNLNLEEKVRELRETVGDLEAMN-EMNDE 339

Query: 486 LQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAF 545
           LQ    + + +LR Q ++  +  RE Q   +A  +   T+ + +   + +K+  +L    
Sbjct: 340 LQENARETELELREQLDMAGARVREAQKRVEAAQE---TVADYQ---QTIKKYRQLTAHL 393

Query: 546 PDLHRPTETQIHGGRSSSVESQITCPTDS 574
            D++R    Q    + +SVE Q   P ++
Sbjct: 394 QDVNRELTNQ----QEASVERQQQPPPET 418



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 42/194 (21%), Positives = 90/194 (46%), Gaps = 33/194 (17%)

Query: 427 STELDKEKARVDSMVRHQESLQAKQ---RALLKQLDSLDQEREELRGSLDEAEAQRARVE 483
           S E +  +A+V  +    E+L+ K+   +A LK+L+    + E+++    + + Q+A ++
Sbjct: 80  SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139

Query: 484 EQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLT---ILELERELEELKER-E 539
            +L+  R++ +  L A++  ++ +      +E AT D  +       L++E+E LKER +
Sbjct: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 199

Query: 540 RLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEEN 599
            L      L    E +   G +SS +                          ++ L+E+N
Sbjct: 200 ELTTDLEILKAEIEEKGSDGAASSYQ--------------------------LKQLEEQN 233

Query: 600 GRLQSMLSKIREVA 613
            RL+  L ++R+++
Sbjct: 234 ARLKDALVRMRDLS 247



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 46/217 (21%), Positives = 95/217 (43%), Gaps = 8/217 (3%)

Query: 280 RKDLT---RLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
           RK LT    + + V A  AQL     + +GL   A + E A K  +      +    +CL
Sbjct: 697 RKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALE-ELAFKASEQIYGTPSSSPYECL 755

Query: 337 SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQ 396
            +       L++  + L T M   E + ++       VE +A  L+ E         +++
Sbjct: 756 RQ---SCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812

Query: 397 QLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMV-RHQESLQAKQRALL 455
             E  +++L+  +++    L  A  ++     +LD      D  + + Q  L+  Q  L 
Sbjct: 813 DRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLR 872

Query: 456 KQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQ 492
           K+    ++  + L+  +D+ EA++A ++++L S+ ++
Sbjct: 873 KKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 909


>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
          Length = 1253

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 69/274 (25%), Positives = 136/274 (49%), Gaps = 43/274 (15%)

Query: 277 AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
           AE +  L  L KH    + QLE+ +  K  +++Q   L++ LK+ +   +   E  E+ +
Sbjct: 219 AEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYM 274

Query: 337 SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQ 396
            E        + +T+D   +MATL++E+ ++R         A+ LQ+E          V+
Sbjct: 275 EE--------MADTAD-AIEMATLDKEMAEER---------AESLQQE----------VE 306

Query: 397 QLEEQVQQLEAQVQLLVGRLEGAGQQVCWAS---TELDKEKARV-DSMVRHQESLQAKQR 452
            L+E+V +L   +++L   +E  G     +S    +L+++ AR+ D++VR ++   ++++
Sbjct: 307 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 366

Query: 453 ---ALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQR 509
               L K ++  +QE E +R   +  + + ++ E  +   +EQ    L A +E+++ L  
Sbjct: 367 EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA-EEMVEMLTD 425

Query: 510 EKQGLEQATTDLRLTILELERELE---ELKERER 540
               LE+   +LR T+ +LE   E   EL+E  R
Sbjct: 426 RNLNLEEKVRELRETVGDLEAMNEMNDELQENAR 459



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 91/449 (20%), Positives = 183/449 (40%), Gaps = 78/449 (17%)

Query: 139 PQKGANQRETPTSKPTTKGEPARSPEYLTTKLIKPSSPVLGLPQTCQEPESIPVRA-SLQ 197
           P   A+  E  +S+P+T  +   +   + T ++     V  LP   +E E +  +   L+
Sbjct: 149 PSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLE 208

Query: 198 FPATTFKNTRSVHSQTIETALVPCDACASVQGSLQKVGKVVISLCQSQNLPSSLGQFQQL 257
               T +  R                 A  +  L+++ K  I L Q Q   S +      
Sbjct: 209 EKLETLRLKR-----------------AEDKAKLKELEKHKIQLEQVQEWKSKM------ 245

Query: 258 VQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHV-EALRAQLEEAEGQKDGLRKQAGKLEQ 316
                               EQ+ DL R  K   +  +  LE  E   + +   A  +E 
Sbjct: 246 -------------------QEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEM 286

Query: 317 ALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEA 376
           A   ++      AEE  + L   + + + L     +L T +  L+ E++++     A   
Sbjct: 287 ATLDKE-----MAEERAESL---QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY 338

Query: 377 KAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGR----LEGAGQQ-------VCW 425
           + +QL+E+  R   A  +++ L    +Q   ++Q L+ +    LE   QQ       +  
Sbjct: 339 QLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQ 398

Query: 426 ASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQ 485
           A + +D+ K +VD+ +  +E ++     L  +  +L+++  ELR ++ + EA    + ++
Sbjct: 399 AESTIDELKEQVDAALGAEEMVE----MLTDRNLNLEEKVRELRETVGDLEAMN-EMNDE 453

Query: 486 LQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAF 545
           LQ    + + +LR Q ++  +  RE Q   +A  +   T+ + +   + +K+  +L    
Sbjct: 454 LQENARETELELREQLDMAGARVREAQKRVEAAQE---TVADYQ---QTIKKYRQLTAHL 507

Query: 546 PDLHRPTETQIHGGRSSSVESQITCPTDS 574
            D++R    Q    + +SVE Q   P ++
Sbjct: 508 QDVNRELTNQ----QEASVERQQQPPPET 532



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 42/194 (21%), Positives = 90/194 (46%), Gaps = 33/194 (17%)

Query: 427 STELDKEKARVDSMVRHQESLQAKQ---RALLKQLDSLDQEREELRGSLDEAEAQRARVE 483
           S E +  +A+V  +    E+L+ K+   +A LK+L+    + E+++    + + Q+A ++
Sbjct: 194 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 253

Query: 484 EQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLT---ILELERELEELKER-E 539
            +L+  R++ +  L A++  ++ +      +E AT D  +       L++E+E LKER +
Sbjct: 254 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 313

Query: 540 RLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEEN 599
            L      L    E +   G +SS +                          ++ L+E+N
Sbjct: 314 ELTTDLEILKAEIEEKGSDGAASSYQ--------------------------LKQLEEQN 347

Query: 600 GRLQSMLSKIREVA 613
            RL+  L ++R+++
Sbjct: 348 ARLKDALVRMRDLS 361



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 46/217 (21%), Positives = 95/217 (43%), Gaps = 8/217 (3%)

Query: 280  RKDLT---RLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
            RK LT    + + V A  AQL     + +GL   A + E A K  +      +    +CL
Sbjct: 811  RKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALE-ELAFKASEQIYGTPSSSPYECL 869

Query: 337  SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQ 396
             +       L++  + L T M   E + ++       VE +A  L+ E         +++
Sbjct: 870  RQ---SCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 926

Query: 397  QLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMV-RHQESLQAKQRALL 455
              E  +++L+  +++    L  A  ++     +LD      D  + + Q  L+  Q  L 
Sbjct: 927  DRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLR 986

Query: 456  KQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQ 492
            K+    ++  + L+  +D+ EA++A ++++L S+ ++
Sbjct: 987  KKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 1023


>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
          Length = 1144

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 69/274 (25%), Positives = 136/274 (49%), Gaps = 43/274 (15%)

Query: 277 AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
           AE +  L  L KH    + QLE+ +  K  +++Q   L++ LK+ +   +   E  E+ +
Sbjct: 105 AEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYM 160

Query: 337 SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQ 396
            E        + +T+D   +MATL++E+ ++R         A+ LQ+E          V+
Sbjct: 161 EE--------MADTAD-AIEMATLDKEMAEER---------AESLQQE----------VE 192

Query: 397 QLEEQVQQLEAQVQLLVGRLEGAGQQVCWAS---TELDKEKARV-DSMVRHQESLQAKQR 452
            L+E+V +L   +++L   +E  G     +S    +L+++ AR+ D++VR ++   ++++
Sbjct: 193 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 252

Query: 453 ---ALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQR 509
               L K ++  +QE E +R   +  + + ++ E  +   +EQ    L A +E+++ L  
Sbjct: 253 EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA-EEMVEMLTD 311

Query: 510 EKQGLEQATTDLRLTILELERELE---ELKERER 540
               LE+   +LR T+ +LE   E   EL+E  R
Sbjct: 312 RNLNLEEKVRELRETVGDLEAMNEMNDELQENAR 345



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 91/449 (20%), Positives = 183/449 (40%), Gaps = 78/449 (17%)

Query: 139 PQKGANQRETPTSKPTTKGEPARSPEYLTTKLIKPSSPVLGLPQTCQEPESIPVRA-SLQ 197
           P   A+  E  +S+P+T  +   +   + T ++     V  LP   +E E +  +   L+
Sbjct: 35  PSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLE 94

Query: 198 FPATTFKNTRSVHSQTIETALVPCDACASVQGSLQKVGKVVISLCQSQNLPSSLGQFQQL 257
               T +  R                 A  +  L+++ K  I L Q Q   S +      
Sbjct: 95  EKLETLRLKR-----------------AEDKAKLKELEKHKIQLEQVQEWKSKM------ 131

Query: 258 VQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHV-EALRAQLEEAEGQKDGLRKQAGKLEQ 316
                               EQ+ DL R  K   +  +  LE  E   + +   A  +E 
Sbjct: 132 -------------------QEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEM 172

Query: 317 ALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEA 376
           A   ++      AEE  + L   + + + L     +L T +  L+ E++++     A   
Sbjct: 173 ATLDKE-----MAEERAESL---QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY 224

Query: 377 KAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGR----LEGAGQQ-------VCW 425
           + +QL+E+  R   A  +++ L    +Q   ++Q L+ +    LE   QQ       +  
Sbjct: 225 QLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQ 284

Query: 426 ASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQ 485
           A + +D+ K +VD+ +  +E ++     L  +  +L+++  ELR ++ + EA    + ++
Sbjct: 285 AESTIDELKEQVDAALGAEEMVE----MLTDRNLNLEEKVRELRETVGDLEAMN-EMNDE 339

Query: 486 LQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAF 545
           LQ    + + +LR Q ++  +  RE Q   +A  +   T+ + +   + +K+  +L    
Sbjct: 340 LQENARETELELREQLDMAGARVREAQKRVEAAQE---TVADYQ---QTIKKYRQLTAHL 393

Query: 546 PDLHRPTETQIHGGRSSSVESQITCPTDS 574
            D++R    Q    + +SVE Q   P ++
Sbjct: 394 QDVNRELTNQ----QEASVERQQQPPPET 418



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 42/194 (21%), Positives = 90/194 (46%), Gaps = 33/194 (17%)

Query: 427 STELDKEKARVDSMVRHQESLQAKQ---RALLKQLDSLDQEREELRGSLDEAEAQRARVE 483
           S E +  +A+V  +    E+L+ K+   +A LK+L+    + E+++    + + Q+A ++
Sbjct: 80  SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139

Query: 484 EQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLT---ILELERELEELKER-E 539
            +L+  R++ +  L A++  ++ +      +E AT D  +       L++E+E LKER +
Sbjct: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 199

Query: 540 RLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEEN 599
            L      L    E +   G +SS +                          ++ L+E+N
Sbjct: 200 ELTTDLEILKAEIEEKGSDGAASSYQ--------------------------LKQLEEQN 233

Query: 600 GRLQSMLSKIREVA 613
            RL+  L ++R+++
Sbjct: 234 ARLKDALVRMRDLS 247



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 46/217 (21%), Positives = 95/217 (43%), Gaps = 8/217 (3%)

Query: 280 RKDLT---RLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
           RK LT    + + V A  AQL     + +GL   A + E A K  +      +    +CL
Sbjct: 697 RKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALE-ELAFKASEQIYGTPSSSPYECL 755

Query: 337 SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQ 396
            +       L++  + L T M   E + ++       VE +A  L+ E         +++
Sbjct: 756 RQ---SCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 812

Query: 397 QLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMV-RHQESLQAKQRALL 455
             E  +++L+  +++    L  A  ++     +LD      D  + + Q  L+  Q  L 
Sbjct: 813 DRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLR 872

Query: 456 KQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQ 492
           K+    ++  + L+  +D+ EA++A ++++L S+ ++
Sbjct: 873 KKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 909


>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
          Length = 1278

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 69/274 (25%), Positives = 136/274 (49%), Gaps = 43/274 (15%)

Query: 277 AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
           AE +  L  L KH    + QLE+ +  K  +++Q   L++ LK+ +   +   E  E+ +
Sbjct: 239 AEDKAKLKELEKH----KIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYM 294

Query: 337 SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQ 396
            E        + +T+D   +MATL++E+ ++R         A+ LQ+E          V+
Sbjct: 295 EE--------MADTAD-AIEMATLDKEMAEER---------AESLQQE----------VE 326

Query: 397 QLEEQVQQLEAQVQLLVGRLEGAGQQVCWAS---TELDKEKARV-DSMVRHQESLQAKQR 452
            L+E+V +L   +++L   +E  G     +S    +L+++ AR+ D++VR ++   ++++
Sbjct: 327 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 386

Query: 453 ---ALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQR 509
               L K ++  +QE E +R   +  + + ++ E  +   +EQ    L A +E+++ L  
Sbjct: 387 EHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGA-EEMVEMLTD 445

Query: 510 EKQGLEQATTDLRLTILELERELE---ELKERER 540
               LE+   +LR T+ +LE   E   EL+E  R
Sbjct: 446 RNLNLEEKVRELRETVGDLEAMNEMNDELQENAR 479



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 91/449 (20%), Positives = 183/449 (40%), Gaps = 78/449 (17%)

Query: 139 PQKGANQRETPTSKPTTKGEPARSPEYLTTKLIKPSSPVLGLPQTCQEPESIPVRA-SLQ 197
           P   A+  E  +S+P+T  +   +   + T ++     V  LP   +E E +  +   L+
Sbjct: 169 PSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLE 228

Query: 198 FPATTFKNTRSVHSQTIETALVPCDACASVQGSLQKVGKVVISLCQSQNLPSSLGQFQQL 257
               T +  R                 A  +  L+++ K  I L Q Q   S +      
Sbjct: 229 EKLETLRLKR-----------------AEDKAKLKELEKHKIQLEQVQEWKSKM------ 265

Query: 258 VQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHV-EALRAQLEEAEGQKDGLRKQAGKLEQ 316
                               EQ+ DL R  K   +  +  LE  E   + +   A  +E 
Sbjct: 266 -------------------QEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEM 306

Query: 317 ALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEA 376
           A   ++      AEE  + L   + + + L     +L T +  L+ E++++     A   
Sbjct: 307 ATLDKE-----MAEERAESL---QQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSY 358

Query: 377 KAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGR----LEGAGQQ-------VCW 425
           + +QL+E+  R   A  +++ L    +Q   ++Q L+ +    LE   QQ       +  
Sbjct: 359 QLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQ 418

Query: 426 ASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQ 485
           A + +D+ K +VD+ +  +E ++     L  +  +L+++  ELR ++ + EA    + ++
Sbjct: 419 AESTIDELKEQVDAALGAEEMVE----MLTDRNLNLEEKVRELRETVGDLEAMN-EMNDE 473

Query: 486 LQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAF 545
           LQ    + + +LR Q ++  +  RE Q   +A  +   T+ + +   + +K+  +L    
Sbjct: 474 LQENARETELELREQLDMAGARVREAQKRVEAAQE---TVADYQ---QTIKKYRQLTAHL 527

Query: 546 PDLHRPTETQIHGGRSSSVESQITCPTDS 574
            D++R    Q    + +SVE Q   P ++
Sbjct: 528 QDVNRELTNQ----QEASVERQQQPPPET 552



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 42/194 (21%), Positives = 90/194 (46%), Gaps = 33/194 (17%)

Query: 427 STELDKEKARVDSMVRHQESLQAKQ---RALLKQLDSLDQEREELRGSLDEAEAQRARVE 483
           S E +  +A+V  +    E+L+ K+   +A LK+L+    + E+++    + + Q+A ++
Sbjct: 214 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 273

Query: 484 EQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLT---ILELERELEELKER-E 539
            +L+  R++ +  L A++  ++ +      +E AT D  +       L++E+E LKER +
Sbjct: 274 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVD 333

Query: 540 RLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEEN 599
            L      L    E +   G +SS +                          ++ L+E+N
Sbjct: 334 ELTTDLEILKAEIEEKGSDGAASSYQ--------------------------LKQLEEQN 367

Query: 600 GRLQSMLSKIREVA 613
            RL+  L ++R+++
Sbjct: 368 ARLKDALVRMRDLS 381



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 46/217 (21%), Positives = 95/217 (43%), Gaps = 8/217 (3%)

Query: 280  RKDLT---RLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
            RK LT    + + V A  AQL     + +GL   A + E A K  +      +    +CL
Sbjct: 831  RKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALE-ELAFKASEQIYGTPSSSPYECL 889

Query: 337  SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQ 396
             +       L++  + L T M   E + ++       VE +A  L+ E         +++
Sbjct: 890  RQ---SCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLE 946

Query: 397  QLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMV-RHQESLQAKQRALL 455
              E  +++L+  +++    L  A  ++     +LD      D  + + Q  L+  Q  L 
Sbjct: 947  DRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLR 1006

Query: 456  KQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQ 492
            K+    ++  + L+  +D+ EA++A ++++L S+ ++
Sbjct: 1007 KKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKR 1043


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 74/363 (20%), Positives = 159/363 (43%), Gaps = 43/363 (11%)

Query: 276  AAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQC 335
            +AE+ K++  + +    L+  LE++E +    RK+  +   +L QE+   + Q + ++  
Sbjct: 842  SAEREKEMASMKEEFTRLKEALEKSEAR----RKELEEKMVSLLQEKNDLQLQVQAEQDN 897

Query: 336  LSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQV 395
            L++ E    QL+     L+ K+  +   L+ + E    + AK ++L++E    +  +R +
Sbjct: 898  LADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE---CSELKRDI 954

Query: 396  QQLEEQVQQLEAQVQLLVGRLEGAGQQVCWAS---TELDKEKARVDSMVRHQESL----- 447
              LE  + ++E +      +++   +++        +L KEK  +     HQ++L     
Sbjct: 955  DDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQE--AHQQALDDLQA 1012

Query: 448  -QAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQS 506
             + K   L K    L+Q+ ++L GSL+    Q  +V   L+  + + +  L+  QE +  
Sbjct: 1013 EEDKVNTLTKAKVKLEQQVDDLEGSLE----QEKKVRMDLERAKRKLEGDLKLTQESIMD 1068

Query: 507  LQREKQGLEQ--ATTDLRLTIL------------ELERELEELKERERLLVAFPDLHRPT 552
            L+ +KQ L++     D  L  L            +L+++L+EL+ R   L    +  R  
Sbjct: 1069 LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTA 1128

Query: 553  ETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREV 612
              ++   RS           +   +++ +E    A  ++I + ++     Q M   + E 
Sbjct: 1129 RAKVEKLRSD-------LSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEA 1181

Query: 613  AQQ 615
              Q
Sbjct: 1182 TLQ 1184



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 90/389 (23%), Positives = 167/389 (42%), Gaps = 55/389 (14%)

Query: 278  EQRKDLTR-LSKHVEALRA---QLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDE 333
            +Q +DL R L + V+A  A    L+ A    D LR+Q  +  +A  + Q    +   E  
Sbjct: 1310 QQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1369

Query: 334  QCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGER------ 387
            Q  +++E D  Q   E  + K K+A   + L++  E+ +AV AK   L++   R      
Sbjct: 1370 QWRTKYETDAIQRTEELEEAKKKLA---QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIE 1426

Query: 388  ------------RAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKA 435
                         AA +++ +  ++ + + + + +     LE + ++    STEL K K 
Sbjct: 1427 DLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKN 1486

Query: 436  RVDSMVRHQESLQAKQRALLKQLDSLDQ----------EREELRGSL--DEAEAQRARVE 483
              +  + H E+ + + + L +++  L +          E E++R  L  ++ E Q A  E
Sbjct: 1487 AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEE 1546

Query: 484  EQLQSEREQGQCQLRAQQELLQ-------SLQREKQGLEQATTDLRLTILELERELE-EL 535
             +   E E+G+  LRAQ E  Q        L  + + +EQA  +    +  L+  L+ E 
Sbjct: 1547 AEASLEHEEGKI-LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAET 1605

Query: 536  KERERLLVAFPDLH---RPTETQIHGGRSSSVESQITCPTDSGNVTD---HMERQVQAND 589
            + R   L     +       E Q+      + E+Q    +    + D    ++  V+AND
Sbjct: 1606 RSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND 1665

Query: 590  ---IRIRVLQEENGRLQSMLSKIREVAQQ 615
                 I +++  N  LQ+ L ++R V +Q
Sbjct: 1666 DLKENIAIVERRNNLLQAELEELRAVVEQ 1694



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 79/374 (21%), Positives = 165/374 (44%), Gaps = 56/374 (14%)

Query: 277  AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
            +E ++D+  L   +  +  +    E +   L ++   L++ + +    ++   E  +Q L
Sbjct: 948  SELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQAL 1007

Query: 337  SEW--EHDKQQLLTETS-DLKTKMATLERELKQQRESTQAVEAKAQQLQEE----GERRA 389
             +   E DK   LT+    L+ ++  LE  L+Q+++    +E   ++L+ +     E   
Sbjct: 1008 DDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIM 1067

Query: 390  AAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQA 449
              E   QQL+E++++ + ++  L  R+E           +L + +AR++ +   +E L+A
Sbjct: 1068 DLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL---EEELEA 1124

Query: 450  KQRA----------LLKQLDSLDQEREELRGSLD---------EAEAQRARVE-EQLQSE 489
            ++ A          L ++L+ + +  EE  G+           EAE Q+ R + E+   +
Sbjct: 1125 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQ 1184

Query: 490  REQGQCQLRAQQ--------ELLQSLQREKQGLEQATTDLRLTILELERELEELKERERL 541
             E     LR +         E + +LQR KQ LE+  ++ +L + ++   +E++ + +  
Sbjct: 1185 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN 1244

Query: 542  LVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGR 601
            L     + R  E Q++  RS + E+Q        +V D   ++ +        LQ ENG 
Sbjct: 1245 L---EKMCRTLEDQMNEHRSKAEETQ-------RSVNDLTSQRAK--------LQTENGE 1286

Query: 602  LQSMLSKIREVAQQ 615
            L   L +   +  Q
Sbjct: 1287 LSRQLDEKEALISQ 1300



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 71/335 (21%), Positives = 137/335 (40%), Gaps = 41/335 (12%)

Query: 285  RLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQ 344
            RL   +E L   +E +      L K+    ++ L +     +++ EE +  L   + + +
Sbjct: 1420 RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEW----KQKYEESQSELESSQKEAR 1475

Query: 345  QLLTETSDLKT----KMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEE 400
             L TE   LK      +  LE   ++ +   + +    +QL   G+     E+  +QLE 
Sbjct: 1476 SLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEA 1535

Query: 401  QVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVD-SMVRHQESLQAKQRALLKQLD 459
            +  +L++ ++     LE    ++  A  E ++ KA ++  +    E ++  +R  L+ +D
Sbjct: 1536 EKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVD 1595

Query: 460  SLD--------------QEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQ 505
            SL               + ++++ G L+E E Q +           + Q Q+++ Q LL+
Sbjct: 1596 SLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRM----AAEAQKQVKSLQSLLK 1651

Query: 506  SLQREKQGLEQATTDLRLTILELER-------ELEELK------ERERLLVAFPDLHRPT 552
              Q +     +A  DL+  I  +ER       ELEEL+      ER R L     +    
Sbjct: 1652 DTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE 1711

Query: 553  ETQ-IHGGRSSSVESQITCPTDSGNVTDHMERQVQ 586
              Q +H   +S +  +     D   +   +E  VQ
Sbjct: 1712 RVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ 1746



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 82/409 (20%), Positives = 169/409 (41%), Gaps = 39/409 (9%)

Query: 277  AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
            A   K    L   +   R++ EE +   + L  Q  KL+     E G   RQ +E E  +
Sbjct: 1243 ANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT----ENGELSRQLDEKEALI 1298

Query: 337  SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAK-------AQQLQEEGERRA 389
            S+    K   LT T  L+     LE E+K +     A+++         +Q +EE E +A
Sbjct: 1299 SQLTRGK---LTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA 1355

Query: 390  AAERQVQQLEEQVQQLEAQVQL-LVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQ 448
              +R + +   +V Q   + +   + R E   +     +  L + +  V+++     SL+
Sbjct: 1356 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE 1415

Query: 449  AKQRALLKQLDSL--DQEREE-LRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQ 505
              +  L  +++ L  D ER      +LD+ +    ++  + + + E+ Q +L + Q+  +
Sbjct: 1416 KTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEAR 1475

Query: 506  SLQRE----KQGLEQATTDLRLTILE---LERELEELKER----ERLLVAFPDLHRPTET 554
            SL  E    K   E++   L     E   L+ E+ +L E+     + +     + +  E 
Sbjct: 1476 SLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEA 1535

Query: 555  QIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQ 614
            +    +S+  E++ +   + G +   +  Q++ N I+  + ++   + + M     E A+
Sbjct: 1536 EKMELQSALEEAEASLEHEEGKI---LRAQLEFNQIKAEIERKLAEKDEEM-----EQAK 1587

Query: 615  QGGLKLIPQDRLWSPSSKGTQGATPPVQAKSTSPGPLGRQHLPSSRTGR 663
            +  L+++  D L +     T+     ++ K    G L    +  S   R
Sbjct: 1588 RNHLRVV--DSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANR 1634



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 64/289 (22%), Positives = 131/289 (45%), Gaps = 40/289 (13%)

Query: 347  LTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQE------------------EGERR 388
            L ++++ + +MA+++ E  + +E+ +  EA+ ++L+E                  E +  
Sbjct: 839  LLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNL 898

Query: 389  AAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQ 448
            A AE +  QL +   QLEA+V+ +  RLE   +     + +  K +     + R  + L+
Sbjct: 899  ADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE 958

Query: 449  AKQRALLKQLDSLDQE----REELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELL 504
                 + K+  + + +     EE+ G LDE  A+  + ++ LQ   +Q    L+A+++ +
Sbjct: 959  LTLAKVEKEKHATENKVKNLTEEMAG-LDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 1017

Query: 505  QSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSV 564
             +L + K  LEQ   D       LE  LE+ K+         DL R  + ++ G    + 
Sbjct: 1018 NTLTKAKVKLEQQVDD-------LEGSLEQEKKVRM------DLER-AKRKLEGDLKLTQ 1063

Query: 565  ESQITCPTDSGNVTDHMER---QVQANDIRIRVLQEENGRLQSMLSKIR 610
            ES +    D   + + +++   ++ A + RI   Q    +LQ  L +++
Sbjct: 1064 ESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQ 1112



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 80/385 (20%), Positives = 162/385 (42%), Gaps = 58/385 (15%)

Query: 282  DLTRLSKHVEALRAQLEEA-EGQKDGLRKQAGKLEQALKQ----EQGARRRQAEEDEQCL 336
            +L ++ K +EA + +L+ A E  +  L  + GK+ +A  +    +    R+ AE+DE   
Sbjct: 1525 ELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDE--- 1581

Query: 337  SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQ----QLQEEGERRAAAE 392
             E E  K+  L     L+T +    R   +     + +E        QL       A A+
Sbjct: 1582 -EMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQ 1640

Query: 393  RQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWAS-------TELDKEKARVDSMVR--- 442
            +QV+ L+  ++  + Q+   V   +   + +            EL++ +A V+   R   
Sbjct: 1641 KQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRK 1700

Query: 443  --HQESLQAKQR---------ALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSERE 491
               QE ++  +R         +L+ Q   +D +  +L+  ++EA  +    EE+ +    
Sbjct: 1701 LAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAIT 1760

Query: 492  QGQC---QLRAQQELLQSLQREKQGLEQATTDLRLTILELE--------RELEELKERER 540
                   +L+ +Q+    L+R K+ +EQ   DL+  + E E        ++L++L+ R R
Sbjct: 1761 DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR 1820

Query: 541  LLVAFPDLHRPTETQ-IHGGRSSSVE-SQITCPTDSG--------NVTDHMERQVQANDI 590
             L    +  +    + + G R S     ++T  T+          ++ D ++ +V+A   
Sbjct: 1821 ELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYK- 1879

Query: 591  RIRVLQEENGRLQSMLSKIREVAQQ 615
              R  +E   +  + LSK R+V  +
Sbjct: 1880 --RQAEEAEEQANTNLSKFRKVQHE 1902



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 63/292 (21%), Positives = 115/292 (39%), Gaps = 71/292 (24%)

Query: 274  RWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLE------QALKQEQGARRR 327
            R AAE +K +  L   ++  + QL++A    D L++    +E      QA  +E  A   
Sbjct: 1634 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1693

Query: 328  QAEED----EQCLSEWEHDKQQLLTETSDLKTKMATLERELKQ-QRESTQAVEA------ 376
            Q E      EQ L E     Q L ++ + L  +   ++ +L Q Q E  +AV+       
Sbjct: 1694 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEE 1753

Query: 377  -----------KAQQLQEEGERRAAAERQVQQLEE----------------------QVQ 403
                        A++L++E +  A  ER  + +E+                      Q+Q
Sbjct: 1754 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQ 1813

Query: 404  QLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQE--------------SLQA 449
            +LEA+V+ L   LE   ++   +   + K + R+  +    E               LQ 
Sbjct: 1814 KLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQL 1873

Query: 450  KQRALLKQLDSLDQER-------EELRGSLDEAEAQRARVEEQLQSEREQGQ 494
            K +A  +Q +  +++         +++  LDEAE +    E Q+   R + +
Sbjct: 1874 KVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1925


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 83/394 (21%), Positives = 172/394 (43%), Gaps = 44/394 (11%)

Query: 226  SVQGSLQKVGKVVISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTR 285
            ++Q +L +V +V  +L   + L     +F +  ++++ ++     TV +   ++ +    
Sbjct: 788  NLQENLSEVSQVKETL--EKELQILKEKFAEASEEAVSVQRSMQETVNK-LHQKEEQFNM 844

Query: 286  LSKHVEALRAQLEEAEG---QKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHD 342
            LS  +E LR  L + E    +KD   +Q  K ++ L+ +     + + ++   L++   +
Sbjct: 845  LSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDE 904

Query: 343  KQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEG-----ERRAAAERQVQQ 397
             +    +  +L+ K+          ++S + +  KA+Q Q+E      E +   ER++  
Sbjct: 905  LRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD 964

Query: 398  LEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQ 457
            LE++++    Q Q L  R E                +A  ++  +H+E LQ  Q+ LL  
Sbjct: 965  LEKKMETSHNQCQELKARYE----------------RATSETKTKHEEILQNLQKTLLDT 1008

Query: 458  LDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQA 517
             D L   REE  G L E E  R + ++   ++  +   Q      +++ + +EK     +
Sbjct: 1009 EDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQ------IMEQMTKEKTETLAS 1062

Query: 518  TTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNV 577
              D + T  +L+ EL+ LKE    L    +L++  E         +VE+Q     +    
Sbjct: 1063 LEDTKQTNAKLQNELDTLKENN--LKNVEELNKSKEL-------LTVENQKM--EEFRKE 1111

Query: 578  TDHMERQVQANDIRIRVLQEENGRLQSMLSKIRE 611
             + +++       ++  LQEEN +L   L + R+
Sbjct: 1112 IETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1145



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 83/406 (20%), Positives = 167/406 (41%), Gaps = 64/406 (15%)

Query: 238 VISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQL 297
           VI+L +S+ L +++   QQ +++   L+   +  +G   AE  +  T++ K     + ++
Sbjct: 573 VIALWKSK-LETAIASHQQAMEE---LKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEI 628

Query: 298 EEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL-SEWEHDKQQLLTETSDLKTK 356
           E  + Q+D  R    K  +AL+ +     ++ E   + + S+ +  + Q L E  D   K
Sbjct: 629 ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK 688

Query: 357 MATLERELKQQR-------ESTQAVEAKAQQLQEEGE--------RRAAAE--------- 392
           +   E ++K+         E T+ ++    QL+   E        R+A++E         
Sbjct: 689 LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLR 748

Query: 393 RQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQR 452
           +Q++  E+Q++ LE                      E + E ++  S+ R  +  + K  
Sbjct: 749 QQLEAAEKQIKHLE---------------------IEKNAESSKASSITRELQGRELKLT 787

Query: 453 ALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQ 512
            L + L  + Q +E L   L   + + A   E+  S +       R+ QE +  L ++++
Sbjct: 788 NLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ-------RSMQETVNKLHQKEE 840

Query: 513 GLEQATTD---LRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQIT 569
                ++D   LR  + ++E +  E  ERE  L+   +       +I    S    SQ+T
Sbjct: 841 QFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM-KMSGDNSSQLT 899

Query: 570 CPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQ 615
              D   +    ER V+   +++    E    LQ  +  +   A+Q
Sbjct: 900 KMNDELRL---KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ 942



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 73/381 (19%), Positives = 151/381 (39%), Gaps = 46/381 (12%)

Query: 259 QDSMGLRPLPAATVGRWAA--EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQ 316
           ++S+    L  ATV   +   E  KDL    + V  LR +LE          K AG ++ 
Sbjct: 447 EESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLES--------NKPAGDVDM 498

Query: 317 ALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSD-LKTKMATLERELKQQRESTQAVE 375
           +L   Q     Q +     L     D Q+ +T   +    +  T ++E+K    +T+ + 
Sbjct: 499 SLSLLQEISSLQEK-----LEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLS 553

Query: 376 AKAQQLQEEGERRAAAERQV-----QQLEEQV-QQLEAQVQLLVGRLEGAGQQVC-WAST 428
            + + L+ + E        V      +LE  +    +A  +L V   +G G +   +A  
Sbjct: 554 KENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAEL 613

Query: 429 ELDKEKARVD--------------SMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDE 474
           +   EK R+D                  H + ++A +  L+K +   +   E +R  LD+
Sbjct: 614 KTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDK 673

Query: 475 AEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEE 534
           AE Q     E   ++ ++ + +++  + L      + + ++  T+ L+ T    E +L +
Sbjct: 674 AEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT----EEKLLD 729

Query: 535 LKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRV 594
           L    +         +    Q+          +I    +S   +  + R++Q  ++++  
Sbjct: 730 LDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASS-ITRELQGRELKLTN 788

Query: 595 LQEENGRLQSMLSKIREVAQQ 615
           LQE      S +S+++E  ++
Sbjct: 789 LQEN----LSEVSQVKETLEK 805



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 47/203 (23%), Positives = 91/203 (44%), Gaps = 26/203 (12%)

Query: 348 TETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEA 407
           T  S  ++  A+    +     S  +  ++   L E   R A        L+E +++ + 
Sbjct: 303 TSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQ 362

Query: 408 QVQLLVGRLEGAGQQVCWAST---ELDKEKARV-DSMVRHQESLQAKQRALLKQLDSLDQ 463
            ++ L+   +    +V  A++   E+++E A   D   +H   L+AK   L   +++ D+
Sbjct: 363 HIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADR 422

Query: 464 EREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRL 523
           E+ EL   L++ E ++ +VE+           Q R ++E +      K  LE AT   + 
Sbjct: 423 EKVEL---LNQLEEEKRKVED----------LQFRVEEESI-----TKGDLEVATVSEKS 464

Query: 524 TILELEREL----EELKERERLL 542
            I+ELE++L    +E+ E  R L
Sbjct: 465 RIMELEKDLALRVQEVAELRRRL 487


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 83/394 (21%), Positives = 172/394 (43%), Gaps = 44/394 (11%)

Query: 226  SVQGSLQKVGKVVISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTR 285
            ++Q +L +V +V  +L   + L     +F +  ++++ ++     TV +   ++ +    
Sbjct: 823  NLQENLSEVSQVKETL--EKELQILKEKFAEASEEAVSVQRSMQETVNK-LHQKEEQFNM 879

Query: 286  LSKHVEALRAQLEEAEG---QKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHD 342
            LS  +E LR  L + E    +KD   +Q  K ++ L+ +     + + ++   L++   +
Sbjct: 880  LSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDE 939

Query: 343  KQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEG-----ERRAAAERQVQQ 397
             +    +  +L+ K+          ++S + +  KA+Q Q+E      E +   ER++  
Sbjct: 940  LRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD 999

Query: 398  LEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQ 457
            LE++++    Q Q L  R E                +A  ++  +H+E LQ  Q+ LL  
Sbjct: 1000 LEKKMETSHNQCQELKARYE----------------RATSETKTKHEEILQNLQKTLLDT 1043

Query: 458  LDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQA 517
             D L   REE  G L E E  R + ++   ++  +   Q      +++ + +EK     +
Sbjct: 1044 EDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQ------IMEQMTKEKTETLAS 1097

Query: 518  TTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNV 577
              D + T  +L+ EL+ LKE    L    +L++  E         +VE+Q     +    
Sbjct: 1098 LEDTKQTNAKLQNELDTLKENN--LKNVEELNKSKEL-------LTVENQKM--EEFRKE 1146

Query: 578  TDHMERQVQANDIRIRVLQEENGRLQSMLSKIRE 611
             + +++       ++  LQEEN +L   L + R+
Sbjct: 1147 IETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1180



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 83/406 (20%), Positives = 167/406 (41%), Gaps = 64/406 (15%)

Query: 238 VISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQL 297
           VI+L +S+ L +++   QQ +++   L+   +  +G   AE  +  T++ K     + ++
Sbjct: 608 VIALWKSK-LETAIASHQQAMEE---LKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEI 663

Query: 298 EEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL-SEWEHDKQQLLTETSDLKTK 356
           E  + Q+D  R    K  +AL+ +     ++ E   + + S+ +  + Q L E  D   K
Sbjct: 664 ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK 723

Query: 357 MATLERELKQQR-------ESTQAVEAKAQQLQEEGE--------RRAAAE--------- 392
           +   E ++K+         E T+ ++    QL+   E        R+A++E         
Sbjct: 724 LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLR 783

Query: 393 RQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQR 452
           +Q++  E+Q++ LE                      E + E ++  S+ R  +  + K  
Sbjct: 784 QQLEAAEKQIKHLE---------------------IEKNAESSKASSITRELQGRELKLT 822

Query: 453 ALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQ 512
            L + L  + Q +E L   L   + + A   E+  S +       R+ QE +  L ++++
Sbjct: 823 NLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ-------RSMQETVNKLHQKEE 875

Query: 513 GLEQATTD---LRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQIT 569
                ++D   LR  + ++E +  E  ERE  L+   +       +I    S    SQ+T
Sbjct: 876 QFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM-KMSGDNSSQLT 934

Query: 570 CPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQ 615
              D   +    ER V+   +++    E    LQ  +  +   A+Q
Sbjct: 935 KMNDELRL---KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ 977



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 87/431 (20%), Positives = 171/431 (39%), Gaps = 52/431 (12%)

Query: 247 LPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDG 306
           L  +L + QQ ++  +  R L  A V +  +   +    L+   +     + E E + D 
Sbjct: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412

Query: 307 LRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQ 366
           LR       +A  +E+     Q EE+++ + + +   ++      DL+T+       +K+
Sbjct: 413 LRTMV----EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKE 468

Query: 367 QRESTQAVEAKAQQLQEEGERRAAA----ERQVQQLEEQVQQLEAQVQLLVGRLEG---A 419
             +S    + KA +LQ E E    A    + ++ +LE+ +     +V  L  RLE    A
Sbjct: 469 LEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPA 528

Query: 420 G---------QQVCWASTELD----KEKARVDSMVRH----QESLQAKQRALLKQLDSLD 462
           G         Q++     +L+      +  + S+  H    +E+ Q + +AL    + L 
Sbjct: 529 GDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLS 588

Query: 463 QEREELRGSLDEAEAQRARVEEQLQSEREQG-QCQLRAQQELLQSLQR----EKQGLEQA 517
           +E E L+  L+ A  + + V    +S+ E       +A +EL  S  +    E     + 
Sbjct: 589 KENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAEL 648

Query: 518 TTDLRLTILELERELEEL------------KERERLLVAFPDLHRPTETQIHGGRS---S 562
            T +    L+ + E+E L            KE E L      + +  E  +   RS    
Sbjct: 649 KTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDK 708

Query: 563 SVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIP 622
           + +  +    D+ N     E +V+  ++      E+   + +  S+++   +    KL+ 
Sbjct: 709 AEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEE----KLLD 764

Query: 623 QDRLWSPSSKG 633
            D L   SS+G
Sbjct: 765 LDALRKASSEG 775



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 68/360 (18%), Positives = 142/360 (39%), Gaps = 44/360 (12%)

Query: 278 EQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLS 337
           E  KDL    + V  LR +LE          K AG ++ +L   Q     Q +     L 
Sbjct: 503 ELEKDLALRVQEVAELRRRLES--------NKPAGDVDMSLSLLQEISSLQEK-----LE 549

Query: 338 EWEHDKQQLLTETSD-LKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQV- 395
               D Q+ +T   +    +  T ++E+K    +T+ +  + + L+ + E        V 
Sbjct: 550 VTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVI 609

Query: 396 ----QQLEEQV-QQLEAQVQLLVGRLEGAGQQVC-WASTELDKEKARVD----------- 438
                +LE  +    +A  +L V   +G G +   +A  +   EK R+D           
Sbjct: 610 ALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQ 669

Query: 439 ---SMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQC 495
                  H + ++A +  L+K +   +   E +R  LD+AE Q     E   ++ ++ + 
Sbjct: 670 QDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEI 729

Query: 496 QLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQ 555
           +++  + L      + + ++  T+ L+ T    E +L +L    +         +    Q
Sbjct: 730 KVKELEVLQAKCNEQTKVIDNFTSQLKAT----EEKLLDLDALRKASSEGKSEMKKLRQQ 785

Query: 556 IHGGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQ 615
           +          +I    +S   +  + R++Q  ++++  LQE      S +S+++E  ++
Sbjct: 786 LEAAEKQIKHLEIEKNAESSKASS-ITRELQGRELKLTNLQEN----LSEVSQVKETLEK 840


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 105/446 (23%), Positives = 187/446 (41%), Gaps = 92/446 (20%)

Query: 211  SQTIETALVPCDACASVQGSLQK-VGKVVISLCQSQNLPSSLGQ----FQQLVQDSMGLR 265
            SQ +E   +  D     +  LQ+ +  + + L   + + S+L +    F QL+ +   + 
Sbjct: 1405 SQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSIS 1464

Query: 266  PLPAATVGRWAAEQRKDLTR-------LSKHVEA----------LRAQLEEAEGQKDGLR 308
               A    R  AE R+  T+       L + +EA          LRA +E+    KD + 
Sbjct: 1465 ARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVG 1524

Query: 309  KQAGKLE---QALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELK 365
            K   +LE   +AL+Q+    R Q EE E  L   E  K +L      +K   A  ER+L+
Sbjct: 1525 KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK---AQFERDLQ 1581

Query: 366  QQRESTQ--------AVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLE 417
             + E  +         V     +L++E ++RA A    +++E  ++ LEAQ++       
Sbjct: 1582 TRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEA------ 1635

Query: 418  GAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEA 477
                            KAR D +++    LQA       Q+    +E EE R S DE  A
Sbjct: 1636 --------------ANKAR-DEVIKQLRKLQA-------QMKDYQRELEEARASRDEIFA 1673

Query: 478  QRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDL----------RLTILE 527
            Q    E++L+S     + ++   QE L S +R ++  EQ   +L          +  +L+
Sbjct: 1674 QSKESEKKLKSL----EAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLD 1729

Query: 528  LEREL--------EELKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTD 579
             +R L        EEL+E +  +    D  R T  Q+      ++ +++     +   +D
Sbjct: 1730 EKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQV-----DTLNAELAAERSAAQKSD 1784

Query: 580  HMERQVQANDIRIRV-LQEENGRLQS 604
            +  +Q++  +  ++  LQE  G ++S
Sbjct: 1785 NARQQLERQNKELKAKLQELEGAVKS 1810



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 63/266 (23%), Positives = 131/266 (49%), Gaps = 35/266 (13%)

Query: 281  KDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWE 340
            K L ++++  E L+A+ EE    K+   K  G+LE+  ++ Q     Q  E++  L+E  
Sbjct: 842  KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQ-----QLLEEKNILAEQL 896

Query: 341  HDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEE 400
              + +L  E  +++ ++A  ++EL++     ++      +++EE ER    + + ++++ 
Sbjct: 897  QAETELFAEAEEMRARLAAKKQELEEILHDLES------RVEEEEERNQILQNEKKKMQA 950

Query: 401  QVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQES----LQAKQRALLK 456
             +Q LE Q+       EGA Q       +L  EK   ++ ++  E     L+ +    +K
Sbjct: 951  HIQDLEEQLD----EEEGARQ-------KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIK 999

Query: 457  QLDSLDQEREELRGSLDEAE------AQRARVEEQLQSEREQGQCQLRAQQELLQSLQRE 510
            +   ++    E    L E E      A+    +E + S+ E+   +L+ +++  Q L++ 
Sbjct: 1000 EKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEE---RLKKEEKTRQELEKA 1056

Query: 511  KQGLEQATTDLRLTILELERELEELK 536
            K+ L+  TTDL+  I EL+ +++ELK
Sbjct: 1057 KRKLDGETTDLQDQIAELQAQIDELK 1082



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 66/343 (19%), Positives = 146/343 (42%), Gaps = 23/343 (6%)

Query: 281  KDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWE 340
            K   RL + ++ L   L+        L K+  K +Q L +E+    R AEE ++  +E  
Sbjct: 1420 KTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAR 1479

Query: 341  HDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEE 400
              + + L+    L+  +   E   +Q ++    +E       + G+     E+  + LE+
Sbjct: 1480 EKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQ 1539

Query: 401  QVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVD-SMVRHQESLQAKQRALLKQLD 459
            QV+++  Q++ L   L+            +   KA+ +  +    E  + K+R L+KQ+ 
Sbjct: 1540 QVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVR 1599

Query: 460  SLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATT 519
             L+ E E+ R     A A + ++E  L+    Q +   +A+ E+++ L++          
Sbjct: 1600 ELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRK---------- 1649

Query: 520  DLRLTILELERELEELK-ERERLLVAFPDLHRPTET------QIHGGRSSSVESQITCPT 572
             L+  + + +RELEE +  R+ +     +  +  ++      Q+    +SS  ++     
Sbjct: 1650 -LQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQ 1708

Query: 573  DSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQ 615
            +   + D +             L +E  RL++ ++++ E  ++
Sbjct: 1709 ERDELADEITNSASGKS----ALLDEKRRLEARIAQLEEELEE 1747



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 78/359 (21%), Positives = 162/359 (45%), Gaps = 24/359 (6%)

Query: 285  RLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQ 344
            ++  H++ L  QL+E EG +  L+ +    E  +K+ +       +++ + + E +  + 
Sbjct: 947  KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMED 1006

Query: 345  QLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQ 404
            ++   +S L  +    +   K + +    +    ++L++E + R   E+  ++L+ +   
Sbjct: 1007 RIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTD 1066

Query: 405  LEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQE 464
            L+ Q+  L  +++    Q+     EL    AR D    H+ +     R L  Q+  L ++
Sbjct: 1067 LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQED 1126

Query: 465  REELRGSLDEAEAQRARVEEQLQ---SEREQGQCQLRAQQELLQSLQRE----KQGLEQA 517
             E  + S ++AE Q+  + E+L+   +E E       AQQEL    ++E    K+ LE+ 
Sbjct: 1127 FESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE 1186

Query: 518  TTDLRLTILELERE----LEELKERERLLVAF-PDLHRPTETQIHGGRSSSVESQI--TC 570
            T +    I ++ +     LEEL E+      F  +L +  +      +  + E ++    
Sbjct: 1187 TKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQV 1246

Query: 571  PTDSGNVTDHMERQVQ------ANDIRIRV-LQEENGRLQSML---SKIREVAQQGGLK 619
              +S +    ++ QVQ      +   R+RV L E+  +LQ+ L   S + E A++ G+K
Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIK 1305



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 69/280 (24%), Positives = 126/280 (45%), Gaps = 41/280 (14%)

Query: 279  QRKDLTRLSKHVEALR----AQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQ 334
            Q KD  R  +   A R    AQ +E+E +   L  +  +L++ L   + ARR   +E ++
Sbjct: 1653 QMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDE 1712

Query: 335  CLSEWEHD---KQQLLTETSDLKTKMATLERELKQQ-----------RESTQAVEAKAQQ 380
               E  +    K  LL E   L+ ++A LE EL+++           R++T  V+    +
Sbjct: 1713 LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAE 1772

Query: 381  LQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSM 440
            L  E      ++   QQLE Q ++L+A++Q L G ++              K KA + + 
Sbjct: 1773 LAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKS-------------KFKATISA- 1818

Query: 441  VRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSER---EQGQCQL 497
                  L+AK   L +QL+   +ER      +   E +   +  Q++ ER   +Q + Q+
Sbjct: 1819 ------LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQM 1872

Query: 498  RAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKE 537
                  ++ L+R+ +  E+  T    +  +L+REL++  E
Sbjct: 1873 EKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATE 1912



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 73/336 (21%), Positives = 145/336 (43%), Gaps = 23/336 (6%)

Query: 282  DLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEH 341
            D   L+  V+ L+    E+E ++  L  Q  +L   + +    R   AE+  +  +E ++
Sbjct: 1232 DNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDN 1291

Query: 342  DKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQ 401
                LL E      K A     L+ Q + TQ +      LQEE  ++     +++QLEE+
Sbjct: 1292 -VSTLLEEAEKKGIKFAKDAASLESQLQDTQEL------LQEETRQKLNLSSRIRQLEEE 1344

Query: 402  VQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSL 461
               L+ Q +      +   +QV    ++L   K +VD  +   ESL+  ++ LLK  ++L
Sbjct: 1345 KNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEAL 1404

Query: 462  DQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDL 521
             Q  EE   + D+ E    + + +LQ E +     L  Q+++  +L+++++  +Q   + 
Sbjct: 1405 SQRLEEKALAYDKLE----KTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEE 1460

Query: 522  RLTILEL--ERELEELKERERLLVAFPDLHRPTETQIHGGRS---------SSVESQITC 570
            +        ER+  E + RE+   A   L R  E  +              + +E  ++ 
Sbjct: 1461 KSISARYAEERDRAEAEAREKETKAL-SLARALEEALEAKEEFERQNKQLRADMEDLMSS 1519

Query: 571  PTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSML 606
              D G     +E+  +A + ++  ++ +   L+  L
Sbjct: 1520 KDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 60/266 (22%), Positives = 122/266 (45%), Gaps = 24/266 (9%)

Query: 293  LRAQLEEAEGQKDGLRKQAGKLEQALKQEQGA-RRRQAEEDEQCLSEWEHDKQ--QLLTE 349
            L AQ+E A   +D + KQ  KL+  +K  Q      +A  DE      E +K+   L  E
Sbjct: 1629 LEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAE 1688

Query: 350  TSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLE--- 406
               L+ ++A+ ER    +R + Q  +  A ++      ++A   + ++LE ++ QLE   
Sbjct: 1689 ILQLQEELASSERA---RRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEEL 1745

Query: 407  ----AQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLD 462
                + ++LL  R      QV   + EL  E++        ++ L+ + + L  +L  L+
Sbjct: 1746 EEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELE 1805

Query: 463  -QEREELRGSLDEAEAQRARVEEQLQSEREQGQC-------QLRAQQELLQSLQREKQGL 514
               + + + ++   EA+  ++EEQL+ E ++            +  +E+   ++ E++  
Sbjct: 1806 GAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHA 1865

Query: 515  EQATTDL---RLTILELERELEELKE 537
            +Q    +      + +L+R+LEE +E
Sbjct: 1866 DQYKEQMEKANARMKQLKRQLEEAEE 1891



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 76/366 (20%), Positives = 157/366 (42%), Gaps = 42/366 (11%)

Query: 281  KDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWE 340
            K+   +   +    +QL E E +   L K   K E  +   +     + +++E+   E E
Sbjct: 999  KEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLE----ERLKKEEKTRQELE 1054

Query: 341  HDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGE----RRAAAERQVQ 396
              K++L  ET+DL+ ++A L+ ++ + +      E + Q     G+     +  A + V+
Sbjct: 1055 KAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVR 1114

Query: 397  QLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKAR----VDSMVRHQESLQAKQR 452
            +L+ Q+ +L+   +        A +Q    S EL+  K      +D+    QE    +++
Sbjct: 1115 ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQ 1174

Query: 453  ALLKQLDSLDQER------------------EELRGSLDEAEAQRARVEEQ---LQSERE 491
             + +   +L++E                   EEL   L++A+  +A +E+    L+++ +
Sbjct: 1175 EVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNK 1234

Query: 492  QGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPD---- 547
            +  C+++  Q++    + +++ L+    +L   + E +R   EL E+   L    D    
Sbjct: 1235 ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVST 1294

Query: 548  -LHRPTETQIHGGR-SSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSM 605
             L    +  I   + ++S+ESQ+    D+  +     RQ      RIR L+EE   LQ  
Sbjct: 1295 LLEEAEKKGIKFAKDAASLESQL---QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQ 1351

Query: 606  LSKIRE 611
              +  E
Sbjct: 1352 QEEEEE 1357



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 69/306 (22%), Positives = 146/306 (47%), Gaps = 56/306 (18%)

Query: 276  AAEQRKDLTRLSKHVEALRAQLEEA-------EGQKDGLRKQAGKLEQALKQE------- 321
            A +Q++DL   S+ +EAL+ +LE+        +  +    ++  +L++AL++E       
Sbjct: 1137 AEKQKRDL---SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQ 1193

Query: 322  -QGARRRQA----------EEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRES 370
             Q  R+R A          E+ ++  +  E +KQ L T+  +L  ++  L++   +    
Sbjct: 1194 IQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHK 1253

Query: 371  TQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTEL 430
             + ++A+ Q+L     + +  +R   +L E+  +L+ ++  +   LE A ++      + 
Sbjct: 1254 RKKLDAQVQELH---AKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKK----GIKF 1306

Query: 431  DKEKARVDSMVRH-QESLQAKQRA---LLKQLDSLDQEREELRGSLDEAEAQRARVEEQ- 485
             K+ A ++S ++  QE LQ + R    L  ++  L++E+  L+   +E E  R  +E+Q 
Sbjct: 1307 AKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQV 1366

Query: 486  --LQSEREQGQCQL-----------RAQQELLQSLQREKQGLEQ---ATTDLRLTILELE 529
              LQS+    + ++            A+++LL+  +   Q LE+   A   L  T   L+
Sbjct: 1367 LALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ 1426

Query: 530  RELEEL 535
            +EL++L
Sbjct: 1427 QELDDL 1432



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 49/248 (19%), Positives = 107/248 (43%), Gaps = 35/248 (14%)

Query: 356  KMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGR 415
            ++ T  + L Q     + ++AK ++L +  E++   E +++++E + QQL  +  +L  +
Sbjct: 836  RVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQ 895

Query: 416  LEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEA 475
            L+        A TEL  E           E ++A+       L +  QE EE+   L+  
Sbjct: 896  LQ--------AETELFAEA----------EEMRAR-------LAAKKQELEEILHDLESR 930

Query: 476  EAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEEL 535
              +     + LQ+E+++ Q  ++  +E L   +  +Q L+         I ++E E+  L
Sbjct: 931  VEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLL 990

Query: 536  KERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGN--VTDHMERQVQANDIRIR 593
            +++    +         E ++   R +   SQ+    +          +++V  +D+  R
Sbjct: 991  EDQNSKFI--------KEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEER 1042

Query: 594  VLQEENGR 601
            + +EE  R
Sbjct: 1043 LKKEEKTR 1050


>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
          Length = 1094

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 87/380 (22%), Positives = 170/380 (44%), Gaps = 23/380 (6%)

Query: 253 QFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEA-EGQKDGLRKQA 311
           Q Q++V D +  R      + R    +R+ + R    +  +  QL+EA + Q+    +  
Sbjct: 211 QKQEVVSDRVERR---LQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHE 267

Query: 312 GKLEQALKQ---EQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELK-QQ 367
           G ++  L+Q   E+    ++ E   + L++ E  ++ LL +  +L+T++   E + K  Q
Sbjct: 268 GAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQ 327

Query: 368 RESTQAVEAKAQQLQEEGER---RAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVC 424
            + +Q  + ++    E+GE    R   ER+ Q LE+Q+  L  +VQL    +    ++V 
Sbjct: 328 HQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDL--RVQLNFSAMASELEEVK 385

Query: 425 WASTELDKEKARVDSMVRH-QESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVE 483
                 DKEKA + S V +    L+  ++  L+ LD L    +E++   D  EA+R   +
Sbjct: 386 RCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRL----KEIQNHFDTCEAERKHAD 441

Query: 484 EQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERERLLV 543
            Q+       +   +  +  L  LQ+ +   E+A        L+ +  + + K + + L 
Sbjct: 442 LQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLE 501

Query: 544 AFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMER-QVQANDIRI-RVLQEENGR 601
              +    T  ++ G  +  ++ +    T        +E  + + ND+   R LQEE   
Sbjct: 502 RALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEE--E 559

Query: 602 LQSMLSKIREV-AQQGGLKL 620
           L S   K+R++ + Q  L+L
Sbjct: 560 LHSKEEKLRDIKSHQADLEL 579



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 74/329 (22%), Positives = 142/329 (43%), Gaps = 38/329 (11%)

Query: 267 LPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARR 326
           L  + + R A +  K   R    ++   A  EEAE +++ L+ +A +  +  K +     
Sbjct: 442 LQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLE 501

Query: 327 RQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGE 386
           R  E+  + + E      Q+L E  +LKT++    ++++  R+    V  K + LQE  E
Sbjct: 502 RALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTK-RALQE--E 558

Query: 387 RRAAAERQVQQLEEQVQQLEAQVQL---LVGRLEGAGQQVCWASTELDKEKARVDSMVRH 443
              + E +++ ++     LE +V+     + RLE   ++     +++  EKA ++  +  
Sbjct: 559 ELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAE 618

Query: 444 QESLQAKQRALLKQLDSLDQEREELRGSLDE--AEAQRAR-------------------- 481
            +  QA+ +A L ++    ++   +R  L    AE +RA+                    
Sbjct: 619 LKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEE 678

Query: 482 ---VEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKER 538
              +  QL+ ER+  Q +L+   +L  SLQ  K   EQ   +L   +   ++E  E +  
Sbjct: 679 TATIITQLKLERDVHQRELK---DLTSSLQSVKTKHEQNIQEL---MKHFKKEKSEAENH 732

Query: 539 ERLLVAFPDLHRPTETQIHGGRSSSVESQ 567
            R L A   L      +IH G+   ++SQ
Sbjct: 733 IRTLKA-ESLEEKNMAKIHRGQLEKLKSQ 760



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 60/249 (24%), Positives = 110/249 (44%), Gaps = 36/249 (14%)

Query: 318 LKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKM-ATLERELKQQRESTQAVEA 376
           ++   G R  Q  +D   L  +    + L +E   L       L R  +   E+ +A+E 
Sbjct: 143 MRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEE 202

Query: 377 KAQQLQEEGERRAAA---ERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKE 433
             ++L E  ++   +   ER++Q+LE   +++  + +L+  R +  G         L K+
Sbjct: 203 LTEKLNEAQKQEVVSDRVERRLQELE---REMRTERELVERRQDQLGLMSLQLQEALKKQ 259

Query: 434 KARVDSMVRHQESLQAKQRALLKQLDSLDQER---------------------EELRGSL 472
           +A+ D    H+ +++ K R    + + L+QE                      EELR  L
Sbjct: 260 EAKAD---EHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQL 316

Query: 473 DEAEAQRARVEEQL-QSEREQGQCQLRAQQE--LLQSLQREKQGLEQATTDLR--LTILE 527
            +AE  R  ++ Q+ Q  ++Q   Q    ++    + ++REKQ LE+  +DLR  L    
Sbjct: 317 TKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSA 376

Query: 528 LERELEELK 536
           +  ELEE+K
Sbjct: 377 MASELEEVK 385



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 67/297 (22%), Positives = 116/297 (39%), Gaps = 64/297 (21%)

Query: 280 RKDLTRLSKHVEALRAQ-LEEAE------GQKDGLRKQAGKLEQALKQEQGARRRQAEED 332
           +K+ +    H+  L+A+ LEE        GQ + L+ Q  +L + L Q +          
Sbjct: 723 KKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNEN--------- 773

Query: 333 EQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAE 392
                           E   LK K   L+ +L+++         K   ++EE  RR    
Sbjct: 774 ----------------ENKKLKLKYQCLKDQLEERE--------KHISIEEEHLRRMEEA 809

Query: 393 RQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMV--------RHQ 444
           R   QL++Q+  LE + + ++G +       C   ++   EK +V S          R  
Sbjct: 810 RL--QLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWL 867

Query: 445 ESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELL 504
              + K + L ++L   +   + LR  L     Q   + E  +SE +    Q+  Q++LL
Sbjct: 868 AESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLL 927

Query: 505 QSLQREKQGLEQATT-------DLRLTILELER-------ELEELKERERLLVAFPD 547
             + REK+ L + T         L+  ++ LE         LE + E+  LL  F D
Sbjct: 928 DEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKD 984



 Score = 37.7 bits (86), Expect = 0.040
 Identities = 28/111 (25%), Positives = 47/111 (42%)

Query: 274 RWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDE 333
           RW AE +  L  L + ++    + +    Q    R+Q   L +  + E     +Q E  E
Sbjct: 865 RWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQE 924

Query: 334 QCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEE 384
           Q L E   +K+ LL ET     +M +L+  +     STQ      + + E+
Sbjct: 925 QLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEK 975



 Score = 30.0 bits (66), Expect = 8.2
 Identities = 55/290 (18%), Positives = 112/290 (38%), Gaps = 32/290 (11%)

Query: 350 TSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAA-ERQVQQLEEQVQQLEAQ 408
           T ++  K+ T+   L+    + + V+    + +E    +A A E   + LE+ + QL +Q
Sbjct: 34  TVEVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQ 93

Query: 409 VQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRH-------------QESLQAKQRALL 455
             L        G+ +   S           S + H             Q   + + R  +
Sbjct: 94  RLLR----NSGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGIKRMRSRTGV 149

Query: 456 KQLDSLDQEREELRG---SLDEAEAQRARVEEQLQSE---REQGQCQLRAQQELLQSLQR 509
           + +   D +  +L G   SL +  +++ R+ +    E   R +   + +   E L     
Sbjct: 150 RFVQETD-DMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLN 208

Query: 510 EKQGLEQATTDLRLTILELEREL---EELKERERLLVAFPDLHRPTETQIHGGRSSSVES 566
           E Q  E  +  +   + ELERE+    EL ER +  +    L      +    ++   E 
Sbjct: 209 EAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEG 268

Query: 567 QITCPTDSGNVTDHMERQV-QANDIRIRVLQEENGRLQSMLSKIREVAQQ 615
            I    +    T+  + Q+ Q  ++  R+L +  G  +++L ++ E+  Q
Sbjct: 269 AI---KNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQ 315


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 69/254 (27%), Positives = 126/254 (49%), Gaps = 43/254 (16%)

Query: 305 DGLRKQAGKLEQALKQEQGA--RRRQAEEDEQC-LSEWEHDKQQLLTETSDLKTKMATLE 361
           D   K+  +LE   ++E+    RR++ EED++  L E +  +++ L +    + ++  ++
Sbjct: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK 588

Query: 362 RELKQQRESTQAV------EAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGR 415
            E K+Q E   A       +AK ++L EE  ++ AA ++++++E + +Q           
Sbjct: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ----------- 637

Query: 416 LEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQL----------DSLDQER 465
            E   +++ W   E ++         RHQE LQ K+    ++L          +  +QER
Sbjct: 638 -EEEARRLRWLQQEEEER--------RHQELLQKKKEEEQERLRKAAEAKRLAEQREQER 688

Query: 466 EELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTI 525
            E      E   Q  R +E+ + ER+  + + R +QE LQ+ +RE Q  E+A   LRL  
Sbjct: 689 REQERREQERREQERREQERREQERQLAEQERRREQERLQA-ERELQEREKA---LRLQK 744

Query: 526 LELERELEELKERE 539
            +L+RELEE K++E
Sbjct: 745 EQLQRELEEKKKKE 758



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 118/484 (24%), Positives = 190/484 (39%), Gaps = 60/484 (12%)

Query: 91  CMSYLENL---------GSEQMMPPAQAAGPCMSVGLTV-----RRFW---DSLLRLGTL 133
           C SYLE L         GSEQ  PP +A  P  +    V        W   D+ +   T 
Sbjct: 355 CHSYLERLLNVEVPQKVGSEQKEPPEEAE-PVAAAEPEVPENNGNNSWPHNDTEIANST- 412

Query: 134 HQQPLPQKGANQRETPTSKPTTKGEPARSPEYLTTKLIKPSSPVLGLPQTCQEPESIPVR 193
              P P+  A+  ETP+         A   E  T +   P  P    PQ+ +   S    
Sbjct: 413 ---PNPKPAASSPETPS---------AGQQEAKTDQADGPREP----PQSARRKRSYKQA 456

Query: 194 ASLQFPATTFKNTRSVHSQTIETALVPCDACASVQGSLQKVGKVVISLCQSQNLPSSLGQ 253
            S +           +     +T   PC A   V+       +  +   Q   +  +   
Sbjct: 457 VS-ELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPL-----RTFLHTVQRNQMLMTPTS 510

Query: 254 FQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGK 313
             + V  S   R  P     +    QR +  R  +  E LR Q  E E ++  L +   K
Sbjct: 511 APRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVE-EDKRRRLEEVKLK 569

Query: 314 LEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQA 373
            E+ L++   AR R  +  E+   + E    Q+  +T   K +    E + K++  + + 
Sbjct: 570 REERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLA-EEKAKKKAAAKKM 628

Query: 374 VEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKE 433
            E +A++ QEE  RR    +Q ++     + L+ + +    RL  A +    A     +E
Sbjct: 629 EEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAE---QRE 685

Query: 434 KARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSERE-- 491
           + R +   R QE  + ++R         +QER E    L  AE +R R +E+LQ+ERE  
Sbjct: 686 QERREQERREQERREQERR---------EQERREQERQL--AEQERRREQERLQAERELQ 734

Query: 492 QGQCQLRAQQELLQ-SLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHR 550
           + +  LR Q+E LQ  L+ +K+  EQ     R    E E++ +E     + L    D+  
Sbjct: 735 EREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQS 794

Query: 551 PTET 554
           P  T
Sbjct: 795 PACT 798


>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
          Length = 2028

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 79/334 (23%), Positives = 140/334 (41%), Gaps = 41/334 (12%)

Query: 242 CQSQNLPSSLGQFQQLVQDSMGLRP--LPAATVGRWAAEQRKDLTRLSKHVEALRAQLEE 299
           C S  +     + Q L     GLR   L     G    E  K+  +LSK +E L+ QLE 
Sbjct: 460 CASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLER 519

Query: 300 AEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQL------LTETSDL 353
            +     L   + +L +  +Q Q        +  + + + E +K  L      L E S +
Sbjct: 520 EKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQV 579

Query: 354 --KTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQL 411
             + +M  +E+E K   ++      K  QL+ E  +      Q ++  E+ ++LE ++Q 
Sbjct: 580 SSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ- 638

Query: 412 LVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDS----------- 460
              RL+    ++    T L+    +V+++    + LQ + R L K LD+           
Sbjct: 639 ---RLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGL 695

Query: 461 ------LDQEREELRGSLDEAE------AQRARVEEQLQSEREQGQCQLRAQQELLQSLQ 508
                 LD E  ELR  ++         AQ  R  +QL+ E+E    +LR   +LL++L 
Sbjct: 696 ERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKE----ELRKNVDLLKALG 751

Query: 509 REKQGLEQATTDLRLTILELERELEELKERERLL 542
           ++ + LE +   +    L L++ LE    + + L
Sbjct: 752 KKSERLELSYQSVSAENLRLQQSLESSSHKTQTL 785



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 85/372 (22%), Positives = 159/372 (42%), Gaps = 45/372 (12%)

Query: 281 KDLTRLSKHVEALRA----QLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCL 336
           ++  +L   +E L+A    Q+++ E +KD L +    L +  +    AR +  E++ + L
Sbjct: 536 REKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKAL 595

Query: 337 SEWEHDKQQLLTETSDLKTKMATLERELKQQRES---TQAVEAKAQQLQEEGERRA---- 389
            +   +    L   S L+ +   L R+L+Q +E     + +E + Q+LQEE  R A    
Sbjct: 596 HQTVTEANGKL---SQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVT 652

Query: 390 ---AAERQVQQLEEQVQQLEAQ----------VQLLVGRLEGAGQQVCWASTELDKEKAR 436
               A  +V+ LE + Q L+ +          +Q +  +LEG  +     + +LD E   
Sbjct: 653 SLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERD----NKQLDAENLE 708

Query: 437 VDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQ 496
           +  +V        K   + ++   L++E+EELR ++D  +A   + E    S +      
Sbjct: 709 LRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAEN 768

Query: 497 LRAQQELLQSLQREKQGLEQATTDLRLTILELERELEEL-----------KERERLLVAF 545
           LR QQ  L+S   + Q LE    +L      L R+LE L           K+R+ L    
Sbjct: 769 LRLQQS-LESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEV 827

Query: 546 PDLHRPTETQIHGGRS--SSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQ 603
             L +  +      +     VE +     DS      +E++ +A D  +   ++  G+L+
Sbjct: 828 AQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLK 887

Query: 604 SMLSKIREVAQQ 615
            +    R++ +Q
Sbjct: 888 ELEKDNRDLTKQ 899



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 72/331 (21%), Positives = 139/331 (41%), Gaps = 56/331 (16%)

Query: 276 AAEQRKD-LTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEE-DE 333
           AA  R D +  L K    L+++L + E  +D  +K   ++E+ L++       Q +  +E
Sbjct: 372 AARARGDKVHELEKENLQLKSKLHDLELDRDTDKK---RIEELLEENMVLEIAQKQSMNE 428

Query: 334 QCLSEWEHDKQQLLTETSDLKTK-------------MATLERELKQQRESTQAVEAKAQQ 380
                WE ++     + SD   K             +  LE+E +  + + Q +   +  
Sbjct: 429 SAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLV 488

Query: 381 LQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSM 440
           L+E G +    E++  QL +++++L+ Q++    R + + Q +   S EL +EK ++ S 
Sbjct: 489 LEESGLKCGELEKENHQLSKKIEKLQTQLE----REKQSNQDLETLSEELIREKEQLQSD 544

Query: 441 V------------------------------RHQESLQAKQRALLKQLDSLDQEREELRG 470
           +                              R Q S +A+ + + K+  +L Q   E  G
Sbjct: 545 METLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANG 604

Query: 471 SLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLT---ILE 527
            L + E ++ ++   L+  +E+G+   + ++E LQ LQ E   L +  T L      +  
Sbjct: 605 KLSQLEFEKRQLHRDLEQAKEKGERAEKLERE-LQRLQEENGRLARKVTSLETATEKVEA 663

Query: 528 LERELEELKERERLLVAFPDLHRPTETQIHG 558
           LE E + L+   R L    D  +    Q+ G
Sbjct: 664 LEHESQGLQLENRTLRKSLDTLQNVSLQLEG 694



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 57/243 (23%), Positives = 112/243 (46%), Gaps = 8/243 (3%)

Query: 280  RKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARR-RQAEEDEQCLSE 338
            ++ L   S   + L ++L E E ++  LR+    L  A  Q +GA + R+A E E  +++
Sbjct: 772  QQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQE--VAQ 829

Query: 339  WEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQL 398
             E DK+ L  E   L  ++   +  L        AVE +++ L +E  R   A  ++++L
Sbjct: 830  LEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKEL 889

Query: 399  EEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQL 458
            E+  + L  QV +    L    + +     +  +  + +D + +  E +   +  LL++ 
Sbjct: 890  EKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQED 949

Query: 459  DS-LDQEREELRGSLDEAEAQRARVEEQ----LQSEREQGQCQLRAQQELLQSLQREKQG 513
            DS  D + + L G  + A      ++E+    L+++ E+     R  +  LQ L++E + 
Sbjct: 950  DSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECET 1009

Query: 514  LEQ 516
            L Q
Sbjct: 1010 LRQ 1012



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 79/330 (23%), Positives = 137/330 (41%), Gaps = 32/330 (9%)

Query: 287  SKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQL 346
            S  +  +  + ++ E +K+ LRK    L+       G +  + E   Q +S      QQ 
Sbjct: 720  STKLAQMERENQQLEREKEELRKNVDLLKAL-----GKKSERLELSYQSVSAENLRLQQS 774

Query: 347  LTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLE 406
            L E+S  KT+  TLE EL +     QA+    + L+    +   AE+  + LE++V QLE
Sbjct: 775  L-ESSSHKTQ--TLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLE 831

Query: 407  AQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQERE 466
               +LL    +   QQV      LD   A++               A+ K+  +LD+E  
Sbjct: 832  KDKKLLEKEAKRLWQQVELKDAVLDDSTAKLS--------------AVEKESRALDKELA 877

Query: 467  ELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTIL 526
              R    +A  +   +E+  +   +Q     R    L + L  EK   +Q +++L     
Sbjct: 878  RCR----DAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELD---- 929

Query: 527  ELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQVQ 586
            +L +ELE++     LL+   D    T+ +I  GR+ S         +   V   +E Q++
Sbjct: 930  KLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVL--LEAQME 987

Query: 587  ANDIRIRVLQEENGRLQSMLSKIREVAQQG 616
                  R L+ E   L+     +R+   +G
Sbjct: 988  EKASLNRQLESELQMLKKECETLRQNQGEG 1017



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 53/232 (22%), Positives = 97/232 (41%), Gaps = 7/232 (3%)

Query: 292  ALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGAR--RRQAEEDEQCLSEWEHDKQQLLTE 349
            A  A L++ E       +Q+ + E  ++Q    +   R  E + + L E   D  +   E
Sbjct: 1163 AYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAE 1222

Query: 350  TSDLKTKMATLERELKQQRESTQAVE-AKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQ 408
              + + K+ T ERE  QQ + T A+   + Q+L+ E +R      Q   L+ + ++L A 
Sbjct: 1223 LEE-REKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQ---LKGEYEELHAH 1278

Query: 409  VQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREEL 468
             + L   L  A  ++       D+ K +  +M      L      L +   +L++E   L
Sbjct: 1279 TKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHL 1338

Query: 469  RGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTD 520
               +     Q   + EQ    +EQ   + +   + L +L+R K+ LE+   D
Sbjct: 1339 LSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMD 1390



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 60/286 (20%), Positives = 119/286 (41%), Gaps = 29/286 (10%)

Query: 359 TLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEG 418
           T ER+  Q +     +++ +           ++E + Q L  ++   +A+++ +   LE 
Sbjct: 214 TQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDK-QHLAVELADTKARLRRVRQELED 272

Query: 419 AGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREE----------- 467
             +Q+     E+D+    +  + +    L A  R+     D LD  RE+           
Sbjct: 273 KTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELEL 332

Query: 468 --LRGSLDEAEAQRARVEE---------QLQSEREQGQCQLRAQQELLQSLQREKQGLEQ 516
              +  L + +  +AR+EE         + ++  E+     RA+ + +  L++E   L+ 
Sbjct: 333 TRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKS 392

Query: 517 ATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGN 576
              DL L     ++ +EEL E E +++         E+  H G      S+    +D+  
Sbjct: 393 KLHDLELDRDTDKKRIEELLE-ENMVLEIAQKQSMNES-AHLGWELEQLSKNADLSDASR 450

Query: 577 VTDHMERQVQANDIRIRVLQEENGRLQSMLSKIRE---VAQQGGLK 619
            +   E    A+  RI  L++EN  LQS +  +R+   V ++ GLK
Sbjct: 451 KSFVFELNECASS-RILKLEKENQSLQSTIQGLRDASLVLEESGLK 495



 Score = 34.3 bits (77), Expect = 0.44
 Identities = 66/324 (20%), Positives = 115/324 (35%), Gaps = 47/324 (14%)

Query: 237  VVISLCQSQNLPSSLGQFQQ------------LVQDSMGLRPLPAATVGRWAAEQRKDLT 284
            +V+   +SQ L S L +  Q            L +D  G         GR  +  +  L 
Sbjct: 914  LVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLA 973

Query: 285  RLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQ 344
               + +  L AQ+EE    K  L +Q     Q LK+E    R+   E +   + ++H   
Sbjct: 974  MKEEKIVLLEAQMEE----KASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAG 1029

Query: 345  QLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQ 404
            +                        S Q  EA     +E        + +  +LE     
Sbjct: 1030 KTAA---------------------SHQGKEAWGPGHKEATMELLRVKDRAIELERNNAA 1068

Query: 405  LEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQE 464
            L+A+ QLL  +L+    Q    S+++   + +   +  H  +LQ +   L  +  +L  +
Sbjct: 1069 LQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQ 1128

Query: 465  REELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQR----------EKQGL 514
               L       +      E + +S + Q +    A + LLQ  +           E + L
Sbjct: 1129 SAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEAL 1188

Query: 515  EQATTDLRLTILELERELEELKER 538
             +  + L+     LE E +EL ER
Sbjct: 1189 IRQHSCLKTLHRNLELEHKELGER 1212


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 68/252 (26%), Positives = 126/252 (50%), Gaps = 43/252 (17%)

Query: 307 LRKQAGKLEQALKQEQGA--RRRQAEEDEQC-LSEWEHDKQQLLTETSDLKTKMATLERE 363
           + K+  +LE   ++E+    RR++ EED++  L E +  +++ L +    + ++  ++ E
Sbjct: 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 594

Query: 364 LKQQRESTQAV------EAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLE 417
            K+Q E   A       +AK ++L EE  ++ AA ++++++E + +Q            E
Sbjct: 595 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ------------E 642

Query: 418 GAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQL----------DSLDQEREE 467
              +++ W   E ++         RHQE LQ K+    ++L          +  +QER E
Sbjct: 643 EEARRLRWLQQEEEER--------RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE 694

Query: 468 LRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILE 527
                 E   Q  R +E+ + ER+  + + R +QE LQ+ +RE Q  E+A   LRL   +
Sbjct: 695 QERREQERREQERREQERREQERQLAEQERRREQERLQA-ERELQEREKA---LRLQKEQ 750

Query: 528 LERELEELKERE 539
           L+RELEE K++E
Sbjct: 751 LQRELEEKKKKE 762



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 120/494 (24%), Positives = 193/494 (39%), Gaps = 76/494 (15%)

Query: 91  CMSYLENL---------GSEQMMPPAQAAGPCMSVGLTV-----RRFW---DSLLRLGTL 133
           C SYLE L         GSEQ  PP +A  P  +    V        W   D+ +   T 
Sbjct: 355 CHSYLERLLNVEVPQKVGSEQKEPPEEAE-PVAAAEPEVPENNGNNSWPHNDTEIANSTP 413

Query: 134 HQQPLPQK----GANQRETPTSKPTTKGEPARSPEYLTTKLIKPSSPVLGLPQTCQEPES 189
           + +P         A Q+E  T +     EP +S      +  K +   L   Q  ++ E 
Sbjct: 414 NPKPAASSPETPSAGQQEAKTDQADGPREPPQSAR--RKRSYKQAVSELDEEQHLEDEEL 471

Query: 190 IPVRASL-QFPATTFKNTRSVHS-----QTIETALVPCDACASVQGSLQKVGKVVISLCQ 243
            P R+     P    K  R + +     Q  +  + P  A  SV  S  K          
Sbjct: 472 QPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK---------- 521

Query: 244 SQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWAAEQRKDLTRLSKHVEALRAQLEEAEGQ 303
            +N P  +      V+                   QR +  R  +  E LR Q  E E +
Sbjct: 522 -RNTPLRMDPKCSFVEKE----------------RQRLENLRRKEEAEQLRRQKVE-EDK 563

Query: 304 KDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHDKQQLLTETSDLKTKMATLERE 363
           +  L +   K E+ L++   AR R  +  E+   + E    Q+  +T   K +    E +
Sbjct: 564 RRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLA-EEK 622

Query: 364 LKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEAQVQLLVGRLEGAGQQV 423
            K++  + +  E +A++ QEE  RR    +Q ++     + L+ + +    RL  A +  
Sbjct: 623 AKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAK 682

Query: 424 CWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARVE 483
             A     +E+ R +   R QE  + ++R         +QER E    L  AE +R R +
Sbjct: 683 RLAE---QREQERREQERREQERREQERR---------EQERREQERQL--AEQERRREQ 728

Query: 484 EQLQSERE--QGQCQLRAQQELLQ-SLQREKQGLEQATTDLRLTILELERELEELKERER 540
           E+LQ+ERE  + +  LR Q+E LQ  L+ +K+  EQ     R    E E++ +E     +
Sbjct: 729 ERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788

Query: 541 LLVAFPDLHRPTET 554
            L    D+  P  T
Sbjct: 789 ALNVTVDVQSPACT 802



 Score = 34.3 bits (77), Expect = 0.44
 Identities = 55/309 (17%), Positives = 129/309 (41%), Gaps = 42/309 (13%)

Query: 337 SEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQ 396
           + W H+  ++   T + K   ++ E     Q+E+        ++  +   R+ + ++ V 
Sbjct: 399 NSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVS 458

Query: 397 QLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQ--AKQRAL 454
           +L+E+    + ++Q    +   +    C AS  +   +  + ++ R+Q  +   +  R++
Sbjct: 459 ELDEEQHLEDEELQPPRSKTPSSP---CPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSV 515

Query: 455 LKQL-------------DSLDQEREELRGSLDEAEAQ---RARVEEQLQSEREQGQCQLR 498
           +K                 +++ER+ L     + EA+   R +VEE  +   E+ + +  
Sbjct: 516 MKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKRE 575

Query: 499 AQ-QELLQSLQREKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIH 557
            + +++LQ+ +R +Q  E+    +     +++ + E+ KE ERL           + +  
Sbjct: 576 ERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE-ERL------AEEKAKKKAA 628

Query: 558 GGRSSSVESQITCPTDSGNVTDHMERQVQANDIRIRVLQEENGRLQSMLSKIREVAQQGG 617
             +   VE++              +++ +A  +R    +EE  R Q +L K +E  Q+  
Sbjct: 629 AKKMEEVEAR-------------RKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERL 675

Query: 618 LKLIPQDRL 626
            K     RL
Sbjct: 676 RKAAEAKRL 684


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.128    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,737,237
Number of Sequences: 37866
Number of extensions: 1648375
Number of successful extensions: 26887
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 635
Number of HSP's successfully gapped in prelim test: 1249
Number of HSP's that attempted gapping in prelim test: 10094
Number of HSP's gapped (non-prelim): 8275
length of query: 752
length of database: 18,247,518
effective HSP length: 110
effective length of query: 642
effective length of database: 14,082,258
effective search space: 9040809636
effective search space used: 9040809636
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.