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Search of human proteins with 19424132
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19424132 NIMA-related kinase 7 [Homo sapiens]
(302 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 622 e-178
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 488 e-138
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens] 488 e-138
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 189 3e-48
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 187 1e-47
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 179 3e-45
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 177 1e-44
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 171 1e-42
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 171 1e-42
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 171 1e-42
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens] 171 1e-42
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens] 171 1e-42
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens] 171 1e-42
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 171 1e-42
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 168 6e-42
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 143 2e-34
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 143 2e-34
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 142 5e-34
gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens] 136 3e-32
gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens] 136 3e-32
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 134 1e-31
gi|148746218 TAO kinase 3 [Homo sapiens] 133 2e-31
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 132 3e-31
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 132 3e-31
gi|4826878 oxidative-stress responsive 1 [Homo sapiens] 132 4e-31
gi|45439370 TAO kinase 1 [Homo sapiens] 131 8e-31
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 130 2e-30
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 130 2e-30
gi|55956904 mitogen-activated protein kinase kinase kinase 4 iso... 126 2e-29
gi|55956902 mitogen-activated protein kinase kinase kinase 4 iso... 126 2e-29
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 622 bits (1603), Expect = e-178
Identities = 302/302 (100%), Positives = 302/302 (100%)
Query: 1 MDEQSQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPV 60
MDEQSQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPV
Sbjct: 1 MDEQSQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPV 60
Query: 61 ALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLS 120
ALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLS
Sbjct: 61 ALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLS 120
Query: 121 RMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDL 180
RMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDL
Sbjct: 121 RMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDL 180
Query: 181 GLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDK 240
GLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDK
Sbjct: 181 GLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDK 240
Query: 241 MNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTA 300
MNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTA
Sbjct: 241 MNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTA 300
Query: 301 SS 302
SS
Sbjct: 301 SS 302
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 488 bits (1256), Expect = e-138
Identities = 238/293 (81%), Positives = 264/293 (90%), Gaps = 6/293 (2%)
Query: 11 PPVPQFQPQKALRPDMGYN-TLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFD 69
PP PQ P + + +LA+F+IEKKIGRGQFSEVY+A CLLD VALKKVQIF+
Sbjct: 60 PPDPQRHPNT-----LSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFE 114
Query: 70 LMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQ 129
+MDAKAR DC+KEI LLKQLNHPN+IKY SFIEDNELNIVLELADAGDLS+MIK+FKKQ
Sbjct: 115 MMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQ 174
Query: 130 KRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSK 189
KRLIPERTVWKYFVQLCSA+EHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSS+
Sbjct: 175 KRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSE 234
Query: 190 TTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKK 249
TTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNL+SLC+K
Sbjct: 235 TTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQK 294
Query: 250 IEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTASS 302
IEQCDYPPLP +HYSE+LR+LV+MCI PDP +RPD+ YV+ VAK+MH +S+
Sbjct: 295 IEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRPDIGYVHQVAKQMHIWMSST 347
>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
Length = 313
Score = 488 bits (1256), Expect = e-138
Identities = 238/293 (81%), Positives = 264/293 (90%), Gaps = 6/293 (2%)
Query: 11 PPVPQFQPQKALRPDMGYN-TLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFD 69
PP PQ P + + +LA+F+IEKKIGRGQFSEVY+A CLLD VALKKVQIF+
Sbjct: 26 PPDPQRHPNT-----LSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFE 80
Query: 70 LMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQ 129
+MDAKAR DC+KEI LLKQLNHPN+IKY SFIEDNELNIVLELADAGDLS+MIK+FKKQ
Sbjct: 81 MMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQ 140
Query: 130 KRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSK 189
KRLIPERTVWKYFVQLCSA+EHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSS+
Sbjct: 141 KRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSE 200
Query: 190 TTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKK 249
TTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNL+SLC+K
Sbjct: 201 TTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQK 260
Query: 250 IEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTASS 302
IEQCDYPPLP +HYSE+LR+LV+MCI PDP +RPD+ YV+ VAK+MH +S+
Sbjct: 261 IEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRPDIGYVHQVAKQMHIWMSST 313
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 189 bits (480), Expect = 3e-48
Identities = 103/256 (40%), Positives = 152/256 (59%), Gaps = 7/256 (2%)
Query: 31 LANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLN 90
LA + + +G+G + EV DG +KK+ + + + RA +E LL QL
Sbjct: 3 LAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRA-AEQEAQLLSQLK 61
Query: 91 HPNVIKYYASFIE-DNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSAL 149
HPN++ Y S+ D L IV+ + GDL R +K K Q L+PE V ++FVQ+ AL
Sbjct: 62 HPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQ--LLPENQVVEWFVQIAMAL 119
Query: 150 EHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIH 209
+++H + ++HRD+K NVF+T T ++K+GDLG+ R + A +L+GTPYYMSPE
Sbjct: 120 QYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFS 179
Query: 210 ENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQ 269
YN+KSD+W+LGC +YEMA L+ F MN SL +I + PP+P D YS EL +
Sbjct: 180 NKPYNYKSDVWALGCCVYEMATLKHAFNAKDMN--SLVYRIIEGKLPPMPRD-YSPELAE 236
Query: 270 LVNMCINPDPEKRPDV 285
L+ ++ PE+RP V
Sbjct: 237 LIRTMLSKRPEERPSV 252
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 187 bits (474), Expect = 1e-47
Identities = 101/261 (38%), Positives = 150/261 (57%), Gaps = 9/261 (3%)
Query: 38 KKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKY 97
+KIG G F + DG +K++ I M +K R + +E+ +L + HPN+++Y
Sbjct: 8 QKIGEGSFGKAILVKSTEDGRQYVIKEINI-SRMSSKEREESRREVAVLANMKHPNIVQY 66
Query: 98 YASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRV 157
SF E+ L IV++ + GDL + I K L E + +FVQ+C AL+H+H R++
Sbjct: 67 RESFEENGSLYIVMDYCEGGDLFKRINAQKGV--LFQEDQILDWFVQICLALKHVHDRKI 124
Query: 158 MHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKS 217
+HRDIK N+F+T G V+LGD G+ R +S A + +GTPYY+SPE YN KS
Sbjct: 125 LHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKS 184
Query: 218 DIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINP 277
DIW+LGC+LYE+ L+ F M +L KI +PP+ S HYS +LR LV+
Sbjct: 185 DIWALGCVLYELCTLKHAFEAGSMK--NLVLKIISGSFPPV-SLHYSYDLRSLVSQLFKR 241
Query: 278 DPEKRPDVTYVYD---VAKRM 295
+P RP V + + +AKR+
Sbjct: 242 NPRDRPSVNSILEKGFIAKRI 262
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 179 bits (454), Expect = 3e-45
Identities = 95/256 (37%), Positives = 149/256 (58%), Gaps = 7/256 (2%)
Query: 34 FRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPN 93
+ + K IG+G F + Y A D +K++ F+ M + + KE+ LL+++ HPN
Sbjct: 4 YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEIN-FEKMPIQEKEASKKEVILLEKMKHPN 62
Query: 94 VIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMH 153
++ ++ SF E+ L IV+E D GDL + I +++ L E + +FVQ+ L+H+H
Sbjct: 63 IVAFFNSFQENGRLFIVMEYCDGGDLMKRIN--RQRGVLFSEDQILGWFVQISLGLKHIH 120
Query: 154 SRRVMHRDIKPANVFITATGVV-KLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENG 212
R+++HRDIK N+F++ G+V KLGD G+ R ++ A + +GTPYY+SPE
Sbjct: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180
Query: 213 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVN 272
YN K+DIWSLGC+LYE+ L+ PF G+ NL L KI Q + P+ S +S EL L++
Sbjct: 181 YNNKTDIWSLGCVLYELCTLKHPFEGN--NLQQLVLKICQAHFAPI-SPGFSRELHSLIS 237
Query: 273 MCINPDPEKRPDVTYV 288
P RP + +
Sbjct: 238 QLFQVSPRDRPSINSI 253
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 177 bits (449), Expect = 1e-44
Identities = 101/250 (40%), Positives = 153/250 (61%), Gaps = 8/250 (3%)
Query: 40 IGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYA 99
+GRG F V+ D V +K++ + + M + R E +LK LNHPNVI+YY
Sbjct: 10 VGRGAFGIVHLCLRKADQKLVIIKQIPV-EQMTKEERQAAQNECQVLKLLNHPNVIEYYE 68
Query: 100 SFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMH 159
+F+ED L I +E A G L+ I+ K+ L+ E T+ +FVQ+ AL H+H+ ++H
Sbjct: 69 NFLEDKALMIAMEYAPGGTLAEFIQ--KRCNSLLEEETILHFFVQILLALHHVHTHLILH 126
Query: 160 RDIKPANVFITATG-VVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSD 218
RD+K N+ + VVK+GD G+ + SSK+ A +++VGTP Y+SPE YN KSD
Sbjct: 127 RDLKTQNILLDKHRMVVKIGDFGISKILSSKSKA-YTVVGTPCYISPELCEGKPYNQKSD 185
Query: 219 IWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPD 278
IW+LGC+LYE+A+L+ F + NL +L KI + P+ SD YS ELRQLV ++ +
Sbjct: 186 IWALGCVLYELASLKRAF--EAANLPALVLKIMSGTFAPI-SDRYSPELRQLVLSLLSLE 242
Query: 279 PEKRPDVTYV 288
P +RP ++++
Sbjct: 243 PAQRPPLSHI 252
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 171 bits (432), Expect = 1e-42
Identities = 99/269 (36%), Positives = 144/269 (53%), Gaps = 10/269 (3%)
Query: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92
++ + + IG G F A+K++++ + KE LL ++ HP
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSR--KEAVLLAKMKHP 60
Query: 93 NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHM 152
N++ + SF + L IV+E D GDL + IK +++ +L PE + +F Q+C + H+
Sbjct: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIK--QQKGKLFPEDMILNWFTQMCLGVNHI 118
Query: 153 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENG 212
H +RV+HRDIK N+F+T G VKLGD G R S+ A + VGTPYY+ PE
Sbjct: 119 HKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
Query: 213 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVN 272
YN KSDIWSLGC+LYE+ L+ PF + +L K+ Q PLPS HYS EL+ LV
Sbjct: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWK--NLILKVCQGCISPLPS-HYSYELQFLVK 235
Query: 273 MCINPDPEKRPDVTYVYD---VAKRMHAC 298
+P RP T + VA+ + C
Sbjct: 236 QMFKRNPSHRPSATTLLSRGIVARLVQKC 264
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 171 bits (432), Expect = 1e-42
Identities = 99/269 (36%), Positives = 144/269 (53%), Gaps = 10/269 (3%)
Query: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92
++ + + IG G F A+K++++ + KE LL ++ HP
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSR--KEAVLLAKMKHP 60
Query: 93 NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHM 152
N++ + SF + L IV+E D GDL + IK +++ +L PE + +F Q+C + H+
Sbjct: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIK--QQKGKLFPEDMILNWFTQMCLGVNHI 118
Query: 153 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENG 212
H +RV+HRDIK N+F+T G VKLGD G R S+ A + VGTPYY+ PE
Sbjct: 119 HKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
Query: 213 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVN 272
YN KSDIWSLGC+LYE+ L+ PF + +L K+ Q PLPS HYS EL+ LV
Sbjct: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWK--NLILKVCQGCISPLPS-HYSYELQFLVK 235
Query: 273 MCINPDPEKRPDVTYVYD---VAKRMHAC 298
+P RP T + VA+ + C
Sbjct: 236 QMFKRNPSHRPSATTLLSRGIVARLVQKC 264
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 171 bits (432), Expect = 1e-42
Identities = 99/269 (36%), Positives = 144/269 (53%), Gaps = 10/269 (3%)
Query: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92
++ + + IG G F A+K++++ + KE LL ++ HP
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSR--KEAVLLAKMKHP 60
Query: 93 NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHM 152
N++ + SF + L IV+E D GDL + IK +++ +L PE + +F Q+C + H+
Sbjct: 61 NIVAFKESFEAEGHLYIVMEYCDGGDLMQKIK--QQKGKLFPEDMILNWFTQMCLGVNHI 118
Query: 153 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENG 212
H +RV+HRDIK N+F+T G VKLGD G R S+ A + VGTPYY+ PE
Sbjct: 119 HKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
Query: 213 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVN 272
YN KSDIWSLGC+LYE+ L+ PF + +L K+ Q PLPS HYS EL+ LV
Sbjct: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWK--NLILKVCQGCISPLPS-HYSYELQFLVK 235
Query: 273 MCINPDPEKRPDVTYVYD---VAKRMHAC 298
+P RP T + VA+ + C
Sbjct: 236 QMFKRNPSHRPSATTLLSRGIVARLVQKC 264
>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
Length = 470
Score = 171 bits (432), Expect = 1e-42
Identities = 90/260 (34%), Positives = 148/260 (56%), Gaps = 10/260 (3%)
Query: 36 IEKKIGRGQFSEVY----RAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNH 91
+++K+G G F VY + A + + V LK++ + +L + E LL +L+H
Sbjct: 31 LQQKLGSGSFGTVYLVSDKKAKRGEELKV-LKEISVGEL-NPNETVQANLEAQLLSKLDH 88
Query: 92 PNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEH 151
P ++K++ASF+E + I+ E + DL I+ +K+ ++ PE + ++F+QL +++
Sbjct: 89 PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
Query: 152 MHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHEN 211
MH RR++HRD+K NVF+ ++K+GD G+ R A +L GTP+YMSPE +
Sbjct: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
Query: 212 GYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLV 271
GY+ KSDIWSL C+LYEM + F G N S+ KI + D P LP + Y +EL ++
Sbjct: 208 GYDTKSDIWSLACILYEMCCMNHAFAGS--NFLSIVLKIVEGDTPSLP-ERYPKELNAIM 264
Query: 272 NMCINPDPEKRPDVTYVYDV 291
+N +P RP + +
Sbjct: 265 ESMLNKNPSLRPSAIEILKI 284
>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
Length = 599
Score = 171 bits (432), Expect = 1e-42
Identities = 90/260 (34%), Positives = 148/260 (56%), Gaps = 10/260 (3%)
Query: 36 IEKKIGRGQFSEVY----RAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNH 91
+++K+G G F VY + A + + V LK++ + +L + E LL +L+H
Sbjct: 31 LQQKLGSGSFGTVYLVSDKKAKRGEELKV-LKEISVGEL-NPNETVQANLEAQLLSKLDH 88
Query: 92 PNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEH 151
P ++K++ASF+E + I+ E + DL I+ +K+ ++ PE + ++F+QL +++
Sbjct: 89 PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
Query: 152 MHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHEN 211
MH RR++HRD+K NVF+ ++K+GD G+ R A +L GTP+YMSPE +
Sbjct: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
Query: 212 GYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLV 271
GY+ KSDIWSL C+LYEM + F G N S+ KI + D P LP + Y +EL ++
Sbjct: 208 GYDTKSDIWSLACILYEMCCMNHAFAGS--NFLSIVLKIVEGDTPSLP-ERYPKELNAIM 264
Query: 272 NMCINPDPEKRPDVTYVYDV 291
+N +P RP + +
Sbjct: 265 ESMLNKNPSLRPSAIEILKI 284
>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
Length = 645
Score = 171 bits (432), Expect = 1e-42
Identities = 90/260 (34%), Positives = 148/260 (56%), Gaps = 10/260 (3%)
Query: 36 IEKKIGRGQFSEVY----RAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNH 91
+++K+G G F VY + A + + V LK++ + +L + E LL +L+H
Sbjct: 31 LQQKLGSGSFGTVYLVSDKKAKRGEELKV-LKEISVGEL-NPNETVQANLEAQLLSKLDH 88
Query: 92 PNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEH 151
P ++K++ASF+E + I+ E + DL I+ +K+ ++ PE + ++F+QL +++
Sbjct: 89 PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
Query: 152 MHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHEN 211
MH RR++HRD+K NVF+ ++K+GD G+ R A +L GTP+YMSPE +
Sbjct: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
Query: 212 GYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLV 271
GY+ KSDIWSL C+LYEM + F G N S+ KI + D P LP + Y +EL ++
Sbjct: 208 GYDTKSDIWSLACILYEMCCMNHAFAGS--NFLSIVLKIVEGDTPSLP-ERYPKELNAIM 264
Query: 272 NMCINPDPEKRPDVTYVYDV 291
+N +P RP + +
Sbjct: 265 ESMLNKNPSLRPSAIEILKI 284
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 171 bits (432), Expect = 1e-42
Identities = 101/252 (40%), Positives = 143/252 (56%), Gaps = 6/252 (2%)
Query: 40 IGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYA 99
+GRG F E D V K+V + L + K R D + EI +L L H N+I YY
Sbjct: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSE-KERRDALNEIVILALLQHDNIIAYYN 116
Query: 100 SFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMH 159
F+++ L I LE + G+L I +K K E VW Y Q+ SA+ +H ++H
Sbjct: 117 HFMDNTTLLIELEYCNGGNLYDKILR-QKDKLFEEEMVVW-YLFQIVSAVSCIHKAGILH 174
Query: 160 RDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDI 219
RDIK N+F+T ++KLGD GL + +S+ + A +LVGTPYYMSPE YNFKSDI
Sbjct: 175 RDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDI 234
Query: 220 WSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQ-CDYPPLPSDHYSEELRQLVNMCINPD 278
W++GC+++E+ L+ F D N +LC KI Q + S YS EL Q+V+ C++ D
Sbjct: 235 WAVGCVIFELLTLKRTF--DATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQD 292
Query: 279 PEKRPDVTYVYD 290
PE+RP + D
Sbjct: 293 PEQRPTADELLD 304
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 168 bits (425), Expect = 6e-42
Identities = 95/265 (35%), Positives = 148/265 (55%), Gaps = 11/265 (4%)
Query: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92
++ + IG G + + DG + K++ + +A+ + + E++LL++L HP
Sbjct: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQM-LVSEVNLLRELKHP 65
Query: 93 NVIKYYASFIE--DNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALE 150
N+++YY I+ + L IV+E + GDL+ +I K+++ + E V + QL AL+
Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
Query: 151 HMHSRR-----VMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSP 205
H R V+HRD+KPANVF+ VKLGD GL R + T+ A + VGTPYYMSP
Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
Query: 206 ERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSE 265
E+++ YN KSDIWSLGCLLYE+ AL PF + L KI + + +P YS+
Sbjct: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPF--TAFSQKELAGKIREGKFRRIPY-RYSD 242
Query: 266 ELRQLVNMCINPDPEKRPDVTYVYD 290
EL +++ +N RP V + +
Sbjct: 243 ELNEIITRMLNLKDYHRPSVEEILE 267
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 143 bits (360), Expect = 2e-34
Identities = 85/253 (33%), Positives = 130/253 (51%), Gaps = 15/253 (5%)
Query: 40 IGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIK---EIDLLKQLNHPNVIK 96
+G+G + VY G +A+K+V + A + K E+DLLK L H N++
Sbjct: 1067 LGKGAYGTVY-CGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVA 1125
Query: 97 YYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRR 156
Y + +++N ++I +E G +S +I F +PE KY Q+ + ++H
Sbjct: 1126 YLGTCLQENTVSIFMEFVPGGSISSIINRFGP----LPEMVFCKYTKQILQGVAYLHENC 1181
Query: 157 VMHRDIKPANVFITATGVVKLGDLGLGRFFS------SKTTAAHSLVGTPYYMSPERIHE 210
V+HRDIK NV + TG++KL D G R + + + S+ GTPY+M+PE I+E
Sbjct: 1182 VVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINE 1241
Query: 211 NGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQL 270
+GY KSDIWS+GC ++EMA + P + PPLP DH+SE
Sbjct: 1242 SGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLP-DHFSENAADF 1300
Query: 271 VNMCINPDPEKRP 283
V MC+ D +RP
Sbjct: 1301 VRMCLTRDQHERP 1313
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 143 bits (360), Expect = 2e-34
Identities = 85/253 (33%), Positives = 130/253 (51%), Gaps = 15/253 (5%)
Query: 40 IGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIK---EIDLLKQLNHPNVIK 96
+G+G + VY G +A+K+V + A + K E+DLLK L H N++
Sbjct: 249 LGKGAYGTVY-CGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVA 307
Query: 97 YYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRR 156
Y + +++N ++I +E G +S +I F +PE KY Q+ + ++H
Sbjct: 308 YLGTCLQENTVSIFMEFVPGGSISSIINRFGP----LPEMVFCKYTKQILQGVAYLHENC 363
Query: 157 VMHRDIKPANVFITATGVVKLGDLGLGRFFS------SKTTAAHSLVGTPYYMSPERIHE 210
V+HRDIK NV + TG++KL D G R + + + S+ GTPY+M+PE I+E
Sbjct: 364 VVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINE 423
Query: 211 NGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQL 270
+GY KSDIWS+GC ++EMA + P + PPLP DH+SE
Sbjct: 424 SGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLP-DHFSENAADF 482
Query: 271 VNMCINPDPEKRP 283
V MC+ D +RP
Sbjct: 483 VRMCLTRDQHERP 495
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 142 bits (357), Expect = 5e-34
Identities = 88/261 (33%), Positives = 139/261 (53%), Gaps = 15/261 (5%)
Query: 31 LANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLN 90
+ + + + IG G F VY+ VALK + + + R + +EI++++ L
Sbjct: 1 MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELR-NLQREIEIMRGLR 59
Query: 91 HPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALE 150
HPN++ SF D E+ +V + A+ G+L ++++ K +PE V QL SAL
Sbjct: 60 HPNIVHMLDSFETDKEVVVVTDYAE-GELFQILEDDGK----LPEDQVQAIAAQLVSALY 114
Query: 151 HMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHE 210
++HS R++HRD+KP N+ + G +KL D G R S+ T S+ GTP YMSPE + E
Sbjct: 115 YLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEE 174
Query: 211 NGYNFKSDIWSLGCLLYEMAALQSPFYGDKM-NLYSLCKKIEQCDYPPLPSDHYSEELRQ 269
Y+ +D+WS+GC+LYE+A PFY + L SL K + +P S + L+
Sbjct: 175 RPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILK-DPVRWPSTISPCFKNFLQG 233
Query: 270 LVNMCINPDPEKR---PDVTY 287
L + DP +R PD+ Y
Sbjct: 234 L----LTKDPRQRLSWPDLLY 250
>gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens]
Length = 1049
Score = 136 bits (342), Expect = 3e-32
Identities = 85/249 (34%), Positives = 131/249 (52%), Gaps = 13/249 (5%)
Query: 38 KKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKY 97
++IG G F VY A + + VA+KK+ + D IKE+ L++L HPN I+Y
Sbjct: 32 REIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQY 91
Query: 98 YASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRV 157
++ ++ +V+E G S +++ KK + + V +Q L ++HS +
Sbjct: 92 RGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAVTHGALQ---GLAYLHSHNM 147
Query: 158 MHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI---HENGYN 214
+HRD+K N+ ++ G+VKLGD G +S A+S VGTPY+M+PE I E Y+
Sbjct: 148 IHRDVKAGNILLSEPGLVKLGDFG----SASIMAPANSFVGTPYWMAPEVILAMDEGQYD 203
Query: 215 FKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMC 274
K D+WSLG E+A + P + MN S I Q + P L S H+SE R V+ C
Sbjct: 204 GKVDVWSLGITCIELAERKPPLF--NMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSC 261
Query: 275 INPDPEKRP 283
+ P+ RP
Sbjct: 262 LQKIPQDRP 270
>gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens]
Length = 1235
Score = 136 bits (342), Expect = 3e-32
Identities = 85/249 (34%), Positives = 131/249 (52%), Gaps = 13/249 (5%)
Query: 38 KKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKY 97
++IG G F VY A + + VA+KK+ + D IKE+ L++L HPN I+Y
Sbjct: 32 REIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQY 91
Query: 98 YASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRV 157
++ ++ +V+E G S +++ KK + + V +Q L ++HS +
Sbjct: 92 RGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAVTHGALQ---GLAYLHSHNM 147
Query: 158 MHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI---HENGYN 214
+HRD+K N+ ++ G+VKLGD G +S A+S VGTPY+M+PE I E Y+
Sbjct: 148 IHRDVKAGNILLSEPGLVKLGDFG----SASIMAPANSFVGTPYWMAPEVILAMDEGQYD 203
Query: 215 FKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMC 274
K D+WSLG E+A + P + MN S I Q + P L S H+SE R V+ C
Sbjct: 204 GKVDVWSLGITCIELAERKPPLF--NMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSC 261
Query: 275 INPDPEKRP 283
+ P+ RP
Sbjct: 262 LQKIPQDRP 270
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 134 bits (337), Expect = 1e-31
Identities = 86/281 (30%), Positives = 145/281 (51%), Gaps = 13/281 (4%)
Query: 8 MQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQI 67
M+ PP P+ + +K + F + +K+G G + V++A G VA+K+V +
Sbjct: 1 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV 60
Query: 68 FDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFK 127
+ + IKEI +++Q + P V+KYY S+ ++ +L IV+E AG +S +I+
Sbjct: 61 ESDLQ-----EIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR--L 113
Query: 128 KQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFS 187
+ K LI E + LE++H R +HRDIK N+ + G KL D G+ +
Sbjct: 114 RNKTLI-EDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLT 172
Query: 188 SKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLC 247
++++GTP++M+PE I E GYN +DIWSLG EMA + P Y D + ++
Sbjct: 173 DTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPP-YADIHPMRAIF 231
Query: 248 KKIEQCDYPPL--PSDHYSEELRQLVNMCINPDPEKRPDVT 286
+ + PP + +S++ V C+ +PE+R T
Sbjct: 232 --MIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATAT 270
>gi|148746218 TAO kinase 3 [Homo sapiens]
Length = 898
Score = 133 bits (334), Expect = 2e-31
Identities = 85/250 (34%), Positives = 128/250 (51%), Gaps = 17/250 (6%)
Query: 39 KIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYY 98
+IG G F VY A VA+KK+ + D +KE+ L+QL HPN I+Y
Sbjct: 29 EIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYK 88
Query: 99 ASFIEDNELNIVLE--LADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRR 156
+++++ +V+E L A DL + K+ + E + L ++HS
Sbjct: 89 GCYLKEHTAWLVMEYCLGSASDL------LEVHKKPLQEVEIAAITHGALHGLAYLHSHA 142
Query: 157 VMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI---HENGY 213
++HRDIK N+ +T G VKL D G +S + A+S VGTPY+M+PE I E Y
Sbjct: 143 LIHRDIKAGNILLTEPGQVKLADFG----SASMASPANSFVGTPYWMAPEVILAMDEGQY 198
Query: 214 NFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNM 273
+ K DIWSLG E+A + P + MN S I Q D P L S+ +++ R+ V+
Sbjct: 199 DGKVDIWSLGITCIELAERKPPLF--NMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDY 256
Query: 274 CINPDPEKRP 283
C+ P++RP
Sbjct: 257 CLQKIPQERP 266
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 132 bits (333), Expect = 3e-31
Identities = 79/248 (31%), Positives = 134/248 (54%), Gaps = 14/248 (5%)
Query: 38 KKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIK-EIDLLKQLNHPNVIK 96
+KIG+G F EV++ +D + ++I DL +A+ + I+ EI +L Q + P V K
Sbjct: 28 EKIGKGSFGEVFKG---IDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTK 84
Query: 97 YYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRR 156
YY S+++D +L I++E G ++ + + E + ++ L+++HS +
Sbjct: 85 YYGSYLKDTKLWIIMEYLGGGSALDLL-----EPGPLDETQIATILREILKGLDYLHSEK 139
Query: 157 VMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFK 216
+HRDIK ANV ++ G VKL D G+ + ++ VGTP++M+PE I ++ Y+ K
Sbjct: 140 KIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSK 199
Query: 217 SDIWSLGCLLYEMAALQSPFYG-DKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCI 275
+DIWSLG E+A + P M + L K + PP +YS+ L++ V C+
Sbjct: 200 ADIWSLGITAIELARGEPPHSELHPMKVLFLIPK----NNPPTLEGNYSKPLKEFVEACL 255
Query: 276 NPDPEKRP 283
N +P RP
Sbjct: 256 NKEPSFRP 263
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 132 bits (333), Expect = 3e-31
Identities = 79/248 (31%), Positives = 134/248 (54%), Gaps = 14/248 (5%)
Query: 38 KKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIK-EIDLLKQLNHPNVIK 96
+KIG+G F EV++ +D + ++I DL +A+ + I+ EI +L Q + P V K
Sbjct: 40 EKIGKGSFGEVFKG---IDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTK 96
Query: 97 YYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRR 156
YY S+++D +L I++E G ++ + + E + ++ L+++HS +
Sbjct: 97 YYGSYLKDTKLWIIMEYLGGGSALDLL-----EPGPLDETQIATILREILKGLDYLHSEK 151
Query: 157 VMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFK 216
+HRDIK ANV ++ G VKL D G+ + ++ VGTP++M+PE I ++ Y+ K
Sbjct: 152 KIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSK 211
Query: 217 SDIWSLGCLLYEMAALQSPFYG-DKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCI 275
+DIWSLG E+A + P M + L K + PP +YS+ L++ V C+
Sbjct: 212 ADIWSLGITAIELARGEPPHSELHPMKVLFLIPK----NNPPTLEGNYSKPLKEFVEACL 267
Query: 276 NPDPEKRP 283
N +P RP
Sbjct: 268 NKEPSFRP 275
>gi|4826878 oxidative-stress responsive 1 [Homo sapiens]
Length = 527
Score = 132 bits (332), Expect = 4e-31
Identities = 76/269 (28%), Positives = 139/269 (51%), Gaps = 22/269 (8%)
Query: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92
++ +++ IG G + V A C VA+K++ + + + +KEI + Q +HP
Sbjct: 16 DYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMD--ELLKEIQAMSQCHHP 73
Query: 93 NVIKYYASFIEDNELNIVLELADAGDLSRMIKHF----KKQKRLIPERTVWKYFVQLCSA 148
N++ YY SF+ +EL +V++L G + +IKH + + ++ E T+ ++
Sbjct: 74 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEG 133
Query: 149 LEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFS-----SKTTAAHSLVGTPYYM 203
LE++H +HRD+K N+ + G V++ D G+ F + ++ + VGTP +M
Sbjct: 134 LEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWM 193
Query: 204 SPERIHE-NGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPS-- 260
+PE + + GY+FK+DIWS G E+A +P++ K + Q D P L +
Sbjct: 194 APEVMEQVRGYDFKADIWSFGITAIELATGAAPYH--KYPPMKVLMLTLQNDPPSLETGV 251
Query: 261 ------DHYSEELRQLVNMCINPDPEKRP 283
Y + R+++++C+ DPEKRP
Sbjct: 252 QDKEMLKKYGKSFRKMISLCLQKDPEKRP 280
>gi|45439370 TAO kinase 1 [Homo sapiens]
Length = 1001
Score = 131 bits (329), Expect = 8e-31
Identities = 82/249 (32%), Positives = 129/249 (51%), Gaps = 13/249 (5%)
Query: 38 KKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKY 97
++IG G F VY A + VA+KK+ + D IKE+ L+++ HPN I+Y
Sbjct: 32 REIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEY 91
Query: 98 YASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRV 157
++ ++ +V+E G S +++ KK + + + +Q L ++HS +
Sbjct: 92 KGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAITHGALQ---GLAYLHSHTM 147
Query: 158 MHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI---HENGYN 214
+HRDIK N+ +T G VKL D G +S + A+S VGTPY+M+PE I E Y+
Sbjct: 148 IHRDIKAGNILLTEPGQVKLADFG----SASMASPANSFVGTPYWMAPEVILAMDEGQYD 203
Query: 215 FKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMC 274
K D+WSLG E+A + P + MN S I Q + P L S+ +S+ R V+ C
Sbjct: 204 GKVDVWSLGITCIELAERKPPLF--NMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSC 261
Query: 275 INPDPEKRP 283
+ P+ RP
Sbjct: 262 LQKIPQDRP 270
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 130 bits (326), Expect = 2e-30
Identities = 79/255 (30%), Positives = 133/255 (52%), Gaps = 13/255 (5%)
Query: 34 FRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPN 93
F + +K+G G + VY+A G VA+K+V + + + IKEI +++Q + P+
Sbjct: 30 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQ-----EIIKEISIMQQCDSPH 84
Query: 94 VIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMH 153
V+KYY S+ ++ +L IV+E AG +S +I+ + + + E + LE++H
Sbjct: 85 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR---LRNKTLTEDEIATILQSTLKGLEYLH 141
Query: 154 SRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGY 213
R +HRDIK N+ + G KL D G+ + ++++GTP++M+PE I E GY
Sbjct: 142 FMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGY 201
Query: 214 NFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPL--PSDHYSEELRQLV 271
N +DIWSLG EMA + P Y D + ++ + + PP + +S+ V
Sbjct: 202 NCVADIWSLGITAIEMAEGKPP-YADIHPMRAIF--MIPTNPPPTFRKPELWSDNFTDFV 258
Query: 272 NMCINPDPEKRPDVT 286
C+ PE+R T
Sbjct: 259 KQCLVKSPEQRATAT 273
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 130 bits (326), Expect = 2e-30
Identities = 78/247 (31%), Positives = 134/247 (54%), Gaps = 14/247 (5%)
Query: 39 KIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIK-EIDLLKQLNHPNVIKY 97
+IG+G F EVY+ +D + ++I DL +A+ + I+ EI +L Q + P + +Y
Sbjct: 25 RIGKGSFGEVYKG---IDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRY 81
Query: 98 YASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRV 157
+ S+++ +L I++E G ++K ++ I T+ + ++ L+++HS R
Sbjct: 82 FGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIA--TILR---EILKGLDYLHSERK 136
Query: 158 MHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKS 217
+HRDIK ANV ++ G VKL D G+ + ++ VGTP++M+PE I ++ Y+FK+
Sbjct: 137 IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKA 196
Query: 218 DIWSLGCLLYEMAALQSPFYG-DKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCIN 276
DIWSLG E+A + P M + L K + PP +S+ ++ V C+N
Sbjct: 197 DIWSLGITAIELAKGEPPNSDLHPMRVLFLIPK----NSPPTLEGQHSKPFKEFVEACLN 252
Query: 277 PDPEKRP 283
DP RP
Sbjct: 253 KDPRFRP 259
>gi|55956904 mitogen-activated protein kinase kinase kinase 4 isoform
a [Homo sapiens]
Length = 1608
Score = 126 bits (317), Expect = 2e-29
Identities = 78/260 (30%), Positives = 136/260 (52%), Gaps = 18/260 (6%)
Query: 39 KIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYY 98
KIG GQ+ +VY + G +A+K+++ F D K + E+ + + + HPN+++Y+
Sbjct: 1348 KIGEGQYGKVYTCISVDTGELMAMKEIR-FQPNDHKTIKETADELKIFEGIKHPNLVRYF 1406
Query: 99 ASFIEDNELNIVLELADAGDLSRMIKHFKKQKRL-IPERTVWKYFVQLCSALEHMHSRRV 157
+ E+ I +E D G L + RL + E + Y Q+ A+ +H +
Sbjct: 1407 GVELHREEMYIFMEYCDEGTLEEV-------SRLGLQEHVIRLYSKQITIAINVLHEHGI 1459
Query: 158 MHRDIKPANVFITATGVVKLGDLG----LGRFFSSKTTAAHSLVGTPYYMSPE---RIHE 210
+HRDIK AN+F+T++G++KLGD G L + +S +GT YM+PE R
Sbjct: 1460 VHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKG 1519
Query: 211 NGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQL 270
G+ +DIWSLGC++ EM + P++ + N + + K+ PP+P + S E +
Sbjct: 1520 EGHGRAADIWSLGCVVIEMVTGKRPWHEYEHN-FQIMYKVGMGHKPPIP-ERLSPEGKDF 1577
Query: 271 VNMCINPDPEKRPDVTYVYD 290
++ C+ DP+ R + + D
Sbjct: 1578 LSHCLESDPKMRWTASQLLD 1597
>gi|55956902 mitogen-activated protein kinase kinase kinase 4 isoform
b [Homo sapiens]
Length = 1558
Score = 126 bits (317), Expect = 2e-29
Identities = 78/260 (30%), Positives = 136/260 (52%), Gaps = 18/260 (6%)
Query: 39 KIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYY 98
KIG GQ+ +VY + G +A+K+++ F D K + E+ + + + HPN+++Y+
Sbjct: 1298 KIGEGQYGKVYTCISVDTGELMAMKEIR-FQPNDHKTIKETADELKIFEGIKHPNLVRYF 1356
Query: 99 ASFIEDNELNIVLELADAGDLSRMIKHFKKQKRL-IPERTVWKYFVQLCSALEHMHSRRV 157
+ E+ I +E D G L + RL + E + Y Q+ A+ +H +
Sbjct: 1357 GVELHREEMYIFMEYCDEGTLEEV-------SRLGLQEHVIRLYSKQITIAINVLHEHGI 1409
Query: 158 MHRDIKPANVFITATGVVKLGDLG----LGRFFSSKTTAAHSLVGTPYYMSPE---RIHE 210
+HRDIK AN+F+T++G++KLGD G L + +S +GT YM+PE R
Sbjct: 1410 VHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKG 1469
Query: 211 NGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQL 270
G+ +DIWSLGC++ EM + P++ + N + + K+ PP+P + S E +
Sbjct: 1470 EGHGRAADIWSLGCVVIEMVTGKRPWHEYEHN-FQIMYKVGMGHKPPIP-ERLSPEGKDF 1527
Query: 271 VNMCINPDPEKRPDVTYVYD 290
++ C+ DP+ R + + D
Sbjct: 1528 LSHCLESDPKMRWTASQLLD 1547
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,143,232
Number of Sequences: 37866
Number of extensions: 535840
Number of successful extensions: 3782
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 748
Number of HSP's successfully gapped in prelim test: 53
Number of HSP's that attempted gapping in prelim test: 1263
Number of HSP's gapped (non-prelim): 925
length of query: 302
length of database: 18,247,518
effective HSP length: 102
effective length of query: 200
effective length of database: 14,385,186
effective search space: 2877037200
effective search space used: 2877037200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.