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Search of human proteins with 194239664
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194239664 SHC (Src homology 2 domain containing)
transforming protein 1 isoform 3 [Homo sapiens]
(584 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194239664 SHC (Src homology 2 domain containing) transforming... 1202 0.0
gi|194239662 SHC (Src homology 2 domain containing) transforming... 1196 0.0
gi|32261324 SHC (Src homology 2 domain containing) transforming ... 978 0.0
gi|194239668 SHC (Src homology 2 domain containing) transforming... 972 0.0
gi|169790811 SHC (Src homology 2 domain containing) transforming... 504 e-143
gi|224586793 src homology 2 domain-containing transforming prote... 499 e-141
gi|222446609 rai-like protein [Homo sapiens] 473 e-133
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ... 164 3e-40
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 67 5e-11
gi|208609985 SH2 domain containing 3A [Homo sapiens] 64 4e-10
gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 63 9e-10
gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens] 63 9e-10
gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 63 9e-10
gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens] 63 9e-10
gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 63 9e-10
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 60 6e-09
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 60 6e-09
gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens] 60 7e-09
gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens] 59 9e-09
gi|242247193 SH2B adaptor protein 2 [Homo sapiens] 58 3e-08
gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Hom... 58 3e-08
gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens] 57 4e-08
gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens] 57 5e-08
gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens] 57 5e-08
gi|222537752 Src homology 2 domain containing transforming prote... 55 1e-07
gi|4885455 SH2B adaptor protein 3 [Homo sapiens] 55 2e-07
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 53 7e-07
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 53 7e-07
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 53 9e-07
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 53 9e-07
>gi|194239664 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 3 [Homo sapiens]
Length = 584
Score = 1202 bits (3110), Expect = 0.0
Identities = 584/584 (100%), Positives = 584/584 (100%)
Query: 1 MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS 60
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
Sbjct: 1 MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS 60
Query: 61 FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR 120
FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR
Sbjct: 61 FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR 120
Query: 121 RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD 180
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
Sbjct: 121 RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD 180
Query: 181 FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS 240
FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
Sbjct: 181 FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS 240
Query: 241 LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV 300
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
Sbjct: 241 LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV 300
Query: 301 ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL 360
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
Sbjct: 301 ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL 360
Query: 361 GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGR 420
GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGR
Sbjct: 361 GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGR 420
Query: 421 ELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSM 480
ELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSM
Sbjct: 421 ELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSM 480
Query: 481 AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE 540
AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE
Sbjct: 481 AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE 540
Query: 541 GVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL 584
GVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL
Sbjct: 541 GVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL 584
>gi|194239662 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 1 [Homo sapiens]
Length = 583
Score = 1196 bits (3094), Expect = 0.0
Identities = 583/584 (99%), Positives = 583/584 (99%), Gaps = 1/584 (0%)
Query: 1 MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS 60
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
Sbjct: 1 MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS 60
Query: 61 FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR 120
FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR
Sbjct: 61 FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR 120
Query: 121 RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD 180
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
Sbjct: 121 RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD 180
Query: 181 FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS 240
FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
Sbjct: 181 FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS 240
Query: 241 LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV 300
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
Sbjct: 241 LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV 300
Query: 301 ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL 360
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
Sbjct: 301 ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL 360
Query: 361 GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGR 420
GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCP GR
Sbjct: 361 GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCP-GR 419
Query: 421 ELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSM 480
ELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSM
Sbjct: 420 ELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSM 479
Query: 481 AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE 540
AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE
Sbjct: 480 AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE 539
Query: 541 GVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL 584
GVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL
Sbjct: 540 GVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL 583
>gi|32261324 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 2 [Homo sapiens]
Length = 474
Score = 978 bits (2528), Expect = 0.0
Identities = 474/474 (100%), Positives = 474/474 (100%)
Query: 111 MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCV 170
MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCV
Sbjct: 1 MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCV 60
Query: 171 EVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGM 230
EVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGM
Sbjct: 61 EVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGM 120
Query: 231 PITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHIL 290
PITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHIL
Sbjct: 121 PITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHIL 180
Query: 291 ECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYY 350
ECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYY
Sbjct: 181 ECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYY 240
Query: 351 NDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQM 410
NDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQM
Sbjct: 241 NDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQM 300
Query: 411 PPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALR 470
PPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALR
Sbjct: 301 PPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALR 360
Query: 471 VPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQ 530
VPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQ
Sbjct: 361 VPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQ 420
Query: 531 PKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL 584
PKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL
Sbjct: 421 PKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL 474
>gi|194239668 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 4 [Homo sapiens]
Length = 473
Score = 972 bits (2512), Expect = 0.0
Identities = 473/474 (99%), Positives = 473/474 (99%), Gaps = 1/474 (0%)
Query: 111 MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCV 170
MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCV
Sbjct: 1 MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCV 60
Query: 171 EVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGM 230
EVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGM
Sbjct: 61 EVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGM 120
Query: 231 PITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHIL 290
PITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHIL
Sbjct: 121 PITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHIL 180
Query: 291 ECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYY 350
ECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYY
Sbjct: 181 ECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYY 240
Query: 351 NDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQM 410
NDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQM
Sbjct: 241 NDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQM 300
Query: 411 PPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALR 470
PPPPPCP GRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALR
Sbjct: 301 PPPPPCP-GRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALR 359
Query: 471 VPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQ 530
VPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQ
Sbjct: 360 VPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQ 419
Query: 531 PKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL 584
PKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL
Sbjct: 420 PKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL 473
>gi|169790811 SHC (Src homology 2 domain containing) transforming
protein 2 [Homo sapiens]
Length = 582
Score = 504 bits (1299), Expect = e-143
Identities = 290/617 (47%), Positives = 369/617 (59%), Gaps = 90/617 (14%)
Query: 21 LEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCSFFPRMSNLRLANP------- 73
+ +G G PP P PP P ++PTT C+ PRM + A P
Sbjct: 1 MTQGPGGRAPP-----------APPAPPEP--EAPTTFCALLPRMPQWKFAAPGGFLGRG 47
Query: 74 ------AGGRPGSKGEPGRAADDG-----EGIVGAAMPDSG---PLPLL---QDMNKLSG 116
AG G+ +P A G ++GA P PLP L +
Sbjct: 48 PAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGS 107
Query: 117 GGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSM 176
GGR G EW R GSF++KP GWLHP+ +V+GPGVSY+VRYMGC+EVL+SM
Sbjct: 108 RGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSM 167
Query: 177 RALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTV 236
R+LDFNTRTQVTREAI+ + EAVPG +G+ +++ P ++ L+S+LG+SNL+FAGM I++ +
Sbjct: 168 RSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAP-NKALASVLGKSNLRFAGMSISIHI 226
Query: 237 STSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGL 296
ST L+L +Q+IANHHM SISFASGGD D +YVAYVAKDP+NQRACHILEC EGL
Sbjct: 227 STDGLSLSVPATRQVIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGL 286
Query: 297 AQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGK 356
AQ +IST+GQAFELRFKQYL +PPK+ P +R+AG + SAW +EE+ +H YYN PGK
Sbjct: 287 AQSIISTVGQAFELRFKQYLHSPPKVALPPERLAGPEESAWGDEEDS-LEHNYYNSIPGK 345
Query: 357 EPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGA-TLP-----VGQPVGGDPEVRKQM 410
EPPLGG+VD RL A +PS A +LP G GD V+
Sbjct: 346 EPPLGGLVDSRL--ALTQPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADA 403
Query: 411 PPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALR 470
PP ++ YVN Q LD P S +DLFDM+PFEDAL+
Sbjct: 404 RGPPD-------HEEHLYVNTQGLDA------------PEPEDSPKKDLFDMRPFEDALK 444
Query: 471 V---------------------PPPPQSVSMA---EQLRGEPWFHGKLSRREAEALLQLN 506
+ PP + +A EQLR EPW+HG++SRR AE +L+ +
Sbjct: 445 LHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRAD 504
Query: 507 GDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLP 566
GDFLVR+S T PGQYVLTG+ +GQPKHLLLVDPEGVVRTKD FES+SHLI +H+ N P
Sbjct: 505 GDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQNGQP 564
Query: 567 IISAGSELCLQQPVERK 583
I++A SEL L+ V R+
Sbjct: 565 IVAAESELHLRGVVSRE 581
>gi|224586793 src homology 2 domain-containing transforming protein
C3 [Homo sapiens]
Length = 594
Score = 499 bits (1286), Expect = e-141
Identities = 301/634 (47%), Positives = 380/634 (59%), Gaps = 99/634 (15%)
Query: 6 PKPKYNPLRNESLSSLEE--------GASGSTPPEELPSPSASSL--GPILPPLPGDDSP 55
P+ KYN RN+S++S+++ G G +A L G L P DD P
Sbjct: 3 PRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAP-DDGP 61
Query: 56 TTLCSFFPRMSNLRLANP------------AGGR-PGSKGEPGRAADDGEGIVGAAMPDS 102
+L ++S+L+L++ AG R GS P AA DG P +
Sbjct: 62 GSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSA------PSA 115
Query: 103 GPLPLLQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSY 162
P + K G+ G E R P RG H +D+V+GPGV+Y
Sbjct: 116 PRAPAMSAARK-------------GRPGDEPLPR-------PPRGAPHASDQVLGPGVTY 155
Query: 163 LVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGR 222
+V+Y+GC+EVL+SMR+LDF+TRTQ+TREAIS VCEAVPGAKGA ++RKP S+ LSSILG+
Sbjct: 156 VVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGK 215
Query: 223 SNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPV 282
SNL+FAGM I+LT+ST+SLNL D KQIIANHHM+SISFASGGDPDT +YVAYVAKDPV
Sbjct: 216 SNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPV 275
Query: 283 NQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEE 342
N+RACHILEC +GLAQDVI +IGQAFELRFKQYL+ P K+ HDRM D W EEE
Sbjct: 276 NRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLD-EPWTEEEG 334
Query: 343 EPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQT---PSHLGATL----- 394
+ DH YYN P K PP GG +D RL+ A QT HLG T
Sbjct: 335 DGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQ 394
Query: 395 --PVGQ---PVGGDPEVRKQMPPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNP 449
P+ Q + PE + + P + P+YVN Q + A P
Sbjct: 395 QTPLRQGSSDIYSTPEGKLHVAPTG---------EAPTYVNTQQIPPQ------AWPAAV 439
Query: 450 AINGSAPR-DLFDMKPFEDALR-------------------VPPPPQSVSMAEQLRGEPW 489
+ S+PR DLFDMKPFEDAL+ V P M E+L+ E W
Sbjct: 440 SSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETW 499
Query: 490 FHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHR 549
+ G++SR+EAE LL+ +GDFLVR+STT PG +VLTG+ +GQ KHLLLVDPEG +RTKD
Sbjct: 500 YQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRV 559
Query: 550 FESVSHLISYHMDNHLPIISAGSELCLQQPVERK 583
F+S+SHLI++H+++ LPI+SAGSELCLQQPVERK
Sbjct: 560 FDSISHLINHHLESSLPIVSAGSELCLQQPVERK 593
>gi|222446609 rai-like protein [Homo sapiens]
Length = 630
Score = 473 bits (1218), Expect = e-133
Identities = 300/640 (46%), Positives = 370/640 (57%), Gaps = 111/640 (17%)
Query: 7 KPKYNPLRNESLSSLEEGASG-STPPEELPSPSASSLGPILPP----LPGDDSPTTLCSF 61
+ KY+ RNES++SL+EG+SG S + P P +L P LP LP +SPT LC+
Sbjct: 27 RAKYSRFRNESITSLDEGSSGGSVGNKGSPQPPHPALAPHLPTEDATLPSQESPTPLCTL 86
Query: 62 FPRMSNLRLANPA----------------------GGRPGSKG---------EPGRAADD 90
PRM++++LANPA PGS G G A
Sbjct: 87 IPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSGPSSPETSLSRSGTAPPP 146
Query: 91 GEGIVG----AAMPDSGPLPLLQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTR 146
+ +VG A PDS PLP G G T +R
Sbjct: 147 QQDLVGHRATALTPDSCPLP----------GPGEPTL--------------------RSR 176
Query: 147 GWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGAT 206
H ++G G++Y VRYMGCVEVLQSMR+LDF RTQVTREAIS +CEAVPGA GA
Sbjct: 177 QDRHFLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAI 236
Query: 207 RRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGG 266
++RKP + LS++LG+SNL+F+GM I LT+ST SL LM D +QIIANHHMQSISFASGG
Sbjct: 237 KKRKPPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGG 296
Query: 267 DPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPH 326
DPDT +YVAYVAKDPVNQRACHILEC G+AQDVISTIGQAFELRFKQYL+NP +
Sbjct: 297 DPDTTDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCE 356
Query: 327 DRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAA------------- 373
D A EE DH+YYN+ PGK+PP+GGV DMR++ A
Sbjct: 357 SEEVHIDSHA-----EEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKL 411
Query: 374 ---PGAARPTA--PNAQTPSH-LGATLPVGQPVGGDPEVRKQMPPPPPCPAGRELFDDPS 427
PG ++ ++ N S +G P G D + K C +LFDDP
Sbjct: 412 CYLPGNSKCSSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKH-----TCRV--DLFDDPC 464
Query: 428 YVNVQNLDKARQAVGGAGPPNPAIN----GSAPRDLFDMKPFEDALRVPPPPQSV-SMAE 482
Y+N Q L + G P + G AP ++P A P S+ + +
Sbjct: 465 YINTQALQSTPGSAGNQRSAQPLGSPWHCGKAPE---TVQP--GATAQPASSHSLPHIKQ 519
Query: 483 QLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGV 542
QL E +HGKLSR+ AE+LL +GDFLVRES T+PGQYVL+GLQ GQ KHLLLVDPEG
Sbjct: 520 QLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGK 579
Query: 543 VRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVER 582
VRTKDH F++V HLI YHMDN LPIIS+GSE+ L+QPV +
Sbjct: 580 VRTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619
>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
sapiens]
Length = 475
Score = 164 bits (414), Expect = 3e-40
Identities = 99/221 (44%), Positives = 126/221 (57%), Gaps = 46/221 (20%)
Query: 387 PSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGP 446
P +G+T G GD V+ PP ++ YVN Q LD
Sbjct: 276 PWDVGST---GTAPPGDGYVQADARGPPD-------HEEHLYVNTQGLDA---------- 315
Query: 447 PNPAINGSAPRDLFDMKPFEDALRV---------------------PPPPQSVSMA---E 482
P S +DLFDM+PFEDAL++ PP + +A E
Sbjct: 316 --PEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEE 373
Query: 483 QLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGV 542
QLR EPW+HG++SRR AE +L+ +GDFLVR+S T PGQYVLTG+ +GQPKHLLLVDPEGV
Sbjct: 374 QLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGV 433
Query: 543 VRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERK 583
VRTKD FES+SHLI +H+ N PI++A SEL L+ V R+
Sbjct: 434 VRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSRE 474
Score = 53.9 bits (128), Expect = 4e-07
Identities = 24/29 (82%), Positives = 28/29 (96%)
Query: 166 YMGCVEVLQSMRALDFNTRTQVTREAISL 194
YMGC+EVL+SMR+LDFNTRTQVTR+A SL
Sbjct: 247 YMGCIEVLRSMRSLDFNTRTQVTRDACSL 275
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 67.0 bits (162), Expect = 5e-11
Identities = 36/106 (33%), Positives = 61/106 (57%), Gaps = 2/106 (1%)
Query: 478 VSMAEQ-LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLL 536
+S++E+ L + W+HG + R EA+ LL+ GDFLVRES PG+YVL+ GQ +H ++
Sbjct: 448 ISISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFII 507
Query: 537 VDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVER 582
+ + R + F ++ LI +H +I+ S + L P+ +
Sbjct: 508 QYVDNMYRFEGTGFSNIPQLIDHHYTTK-QVITKKSGVVLLNPIPK 552
>gi|208609985 SH2 domain containing 3A [Homo sapiens]
Length = 576
Score = 63.9 bits (154), Expect = 4e-10
Identities = 36/98 (36%), Positives = 52/98 (53%), Gaps = 9/98 (9%)
Query: 482 EQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLV---- 537
E L G+PW+HG LSR++AEALLQ NGDFLVR S + G V++ G H +
Sbjct: 8 EDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVAL 67
Query: 538 -----DPEGVVRTKDHRFESVSHLISYHMDNHLPIISA 570
P + + +D +F S+ L+ +M P+ A
Sbjct: 68 RPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQA 105
>gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 62.8 bits (151), Expect = 9e-10
Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)
Query: 475 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 529
P+ + L G PWFHG LSR +A L+ G FLVR+S T G+YVLT G
Sbjct: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572
Query: 530 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 572
+ KHL L ++ EG R + F+S+ ++ + + +P+ S GS
Sbjct: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
>gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens]
Length = 683
Score = 62.8 bits (151), Expect = 9e-10
Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)
Query: 475 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 529
P+ + L G PWFHG LSR +A L+ G FLVR+S T G+YVLT G
Sbjct: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572
Query: 530 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 572
+ KHL L ++ EG R + F+S+ ++ + + +P+ S GS
Sbjct: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
>gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 62.8 bits (151), Expect = 9e-10
Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)
Query: 475 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 529
P+ + L G PWFHG LSR +A L+ G FLVR+S T G+YVLT G
Sbjct: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572
Query: 530 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 572
+ KHL L ++ EG R + F+S+ ++ + + +P+ S GS
Sbjct: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
>gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens]
Length = 756
Score = 62.8 bits (151), Expect = 9e-10
Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)
Query: 475 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 529
P+ + L G PWFHG LSR +A L+ G FLVR+S T G+YVLT G
Sbjct: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572
Query: 530 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 572
+ KHL L ++ EG R + F+S+ ++ + + +P+ S GS
Sbjct: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
>gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 62.8 bits (151), Expect = 9e-10
Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)
Query: 475 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 529
P+ + L G PWFHG LSR +A L+ G FLVR+S T G+YVLT G
Sbjct: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572
Query: 530 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 572
+ KHL L ++ EG R + F+S+ ++ + + +P+ S GS
Sbjct: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 60.1 bits (144), Expect = 6e-09
Identities = 34/104 (32%), Positives = 54/104 (51%), Gaps = 2/104 (1%)
Query: 465 FEDALRVPPPPQSVSMAEQ-LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVL 523
F +PPP Q + ++ L + W+HG + R E LL +GDFLVRES +YVL
Sbjct: 377 FRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQ-EYVL 435
Query: 524 TGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPI 567
+ L G P+H ++ + + R + F S+ LI + + P+
Sbjct: 436 SVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPL 479
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 60.1 bits (144), Expect = 6e-09
Identities = 34/104 (32%), Positives = 54/104 (51%), Gaps = 2/104 (1%)
Query: 465 FEDALRVPPPPQSVSMAEQ-LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVL 523
F +PPP Q + ++ L + W+HG + R E LL +GDFLVRES +YVL
Sbjct: 435 FRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQ-EYVL 493
Query: 524 TGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPI 567
+ L G P+H ++ + + R + F S+ LI + + P+
Sbjct: 494 SVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPL 537
>gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens]
Length = 825
Score = 59.7 bits (143), Expect = 7e-09
Identities = 41/140 (29%), Positives = 69/140 (49%), Gaps = 16/140 (11%)
Query: 454 SAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRE 513
S R + D P + L+ + + +E LR W+HG++ R+ +E L+Q +GDFLVR+
Sbjct: 121 SKERHIMDRTP--EKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRD 178
Query: 514 STTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKD-----------HRFESVSHLISYHMD 562
S ++PG +VLT +H + V+R + F+S+ L+ ++
Sbjct: 179 SLSSPGNFVLTCQWKNLAQHFKI--NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236
Query: 563 NHLPIISAGSELCLQQPVER 582
N P IS S + QP+ R
Sbjct: 237 NRRP-ISQQSGAIIFQPINR 255
>gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]
Length = 860
Score = 59.3 bits (142), Expect = 9e-09
Identities = 60/216 (27%), Positives = 89/216 (41%), Gaps = 22/216 (10%)
Query: 355 GKEPPL--GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPP 412
G +P L GGV D E A + T P TP A P V DP +RK
Sbjct: 101 GPKPNLVPGGVPDPPGLEAAKEVMVKATGPLEDTP----AMEPNPSAVEVDP-IRK---- 151
Query: 413 PPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVP 472
P P G + P +++ R A G + + S + + D P + L
Sbjct: 152 -PEVPTGDVEEERPP----RDVHSER-AAGEPEAGSDYVKFSKEKYILDSSP--EKLHKE 203
Query: 473 PPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPK 532
+ + LR W+HG++ R +E L+Q NGDFL+R+S T+ G YVLT Q
Sbjct: 204 LEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQAL 263
Query: 533 HLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPII 568
H + VV + + +L +H+P +
Sbjct: 264 HFKI---NKVVVKAGESYTHIQYLFEQESFDHVPAL 296
>gi|242247193 SH2B adaptor protein 2 [Homo sapiens]
Length = 675
Score = 57.8 bits (138), Expect = 3e-08
Identities = 35/96 (36%), Positives = 53/96 (55%), Gaps = 6/96 (6%)
Query: 483 QLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSGQPKHL-LL 536
+L PWFHG LSR +A L+ G F++R+S T PG+YVLT G+ KHL L
Sbjct: 454 ELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLS 513
Query: 537 VDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 572
++ G + F+SV ++ + + +P+ S GS
Sbjct: 514 LNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGS 549
>gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Homo
sapiens]
Length = 304
Score = 57.8 bits (138), Expect = 3e-08
Identities = 68/343 (19%), Positives = 124/343 (36%), Gaps = 75/343 (21%)
Query: 139 SFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEA 198
+F K + W+H + + + Y +++G EV Q T+V R+A+
Sbjct: 4 AFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKG-------TEVVRDAV------ 50
Query: 199 VPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQ 258
R+ +R + G+ K + L +S + ++ K++ N +
Sbjct: 51 ---------RKLKFARHIKKSEGQKIPK-----VELQISIYGVKILEPKTKEVQHNCQLH 96
Query: 259 SISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRN 318
ISF + D + N+ C++ + E A+++ TIGQAF+L ++++L +
Sbjct: 97 RISFCADDKTDKRIFTFICKDSESNKHLCYVFDS-EKCAEEITLTIGQAFDLAYRKFLES 155
Query: 319 PPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAAR 378
K V ++AG D E E D + +R+ + +AP A
Sbjct: 156 GGKDVETRKQIAGLQKRIQDLETENMELKNKVQDLENQ---------LRITQVSAPPAGS 206
Query: 379 PTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGRELFDDPSYVNVQNLDKAR 438
T + T ++FD + + +
Sbjct: 207 MTPKSPST----------------------------------DIFDMIPFSPISHQSSMP 232
Query: 439 QAVGGAGPPNPAINGSAPRDLFDMKPFE----DALRVPPPPQS 477
G PP P+ + RDLF +PF+ A PP QS
Sbjct: 233 TRNGTQPPPVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQS 275
>gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens]
Length = 703
Score = 57.4 bits (137), Expect = 4e-08
Identities = 37/130 (28%), Positives = 58/130 (44%), Gaps = 8/130 (6%)
Query: 442 GGAGPPNPA---INGSAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRRE 498
G AG P + S + + D P + L + + LR W+HG++ R
Sbjct: 15 GAAGEPEAGSDYVKFSKEKYILDSSP--EKLHKELEEELKLSSTDLRSHAWYHGRIPREV 72
Query: 499 AEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLIS 558
+E L+Q NGDFL+R+S T+ G YVLT Q H + VV + + +L
Sbjct: 73 SETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKI---NKVVVKAGESYTHIQYLFE 129
Query: 559 YHMDNHLPII 568
+H+P +
Sbjct: 130 QESFDHVPAL 139
>gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens]
Length = 700
Score = 57.0 bits (136), Expect = 5e-08
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 3/85 (3%)
Query: 484 LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVV 543
LR W+HG++ R +E L+Q NGDFL+R+S T+ G YVLT Q H + VV
Sbjct: 55 LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKI---NKVV 111
Query: 544 RTKDHRFESVSHLISYHMDNHLPII 568
+ + +L +H+P +
Sbjct: 112 VKAGESYTHIQYLFEQESFDHVPAL 136
>gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens]
Length = 702
Score = 57.0 bits (136), Expect = 5e-08
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 3/85 (3%)
Query: 484 LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVV 543
LR W+HG++ R +E L+Q NGDFL+R+S T+ G YVLT Q H + VV
Sbjct: 57 LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKI---NKVV 113
Query: 544 RTKDHRFESVSHLISYHMDNHLPII 568
+ + +L +H+P +
Sbjct: 114 VKAGESYTHIQYLFEQESFDHVPAL 138
>gi|222537752 Src homology 2 domain containing transforming protein
D [Homo sapiens]
Length = 340
Score = 55.5 bits (132), Expect = 1e-07
Identities = 60/189 (31%), Positives = 82/189 (43%), Gaps = 16/189 (8%)
Query: 397 GQPVGGDPEVRKQMPPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAP 456
G P G P + +MP PA +D P ++ +A AV P GSA
Sbjct: 158 GPPSGQKPR-QSRMPQEDERPADE--YDQPWEWKKDHISRAF-AVQFDSPEWERTPGSA- 212
Query: 457 RDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQL--NGDFLVRES 514
++L P R P P + V A L +PWFHG L+R +AE+LL L G +LVR S
Sbjct: 213 KELRRPPP-----RSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLS 267
Query: 515 TTTPGQYVLTGLQSGQPKHLLLV---DPEGVVRTKDHRFESVSHLISYHMDNHLPIISAG 571
T P L+ S HL + + V+ F SV L+ ++ LP+ A
Sbjct: 268 ETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGA- 326
Query: 572 SELCLQQPV 580
L L PV
Sbjct: 327 EHLALLYPV 335
>gi|4885455 SH2B adaptor protein 3 [Homo sapiens]
Length = 575
Score = 55.1 bits (131), Expect = 2e-07
Identities = 34/86 (39%), Positives = 47/86 (54%), Gaps = 6/86 (6%)
Query: 488 PWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSGQPKHL-LLVDPEG 541
PWFHG +SR +A L+QL G FLVR+S T G+YVLT G KHL L + G
Sbjct: 363 PWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERG 422
Query: 542 VVRTKDHRFESVSHLISYHMDNHLPI 567
R + F SV ++ + + +P+
Sbjct: 423 QCRVQHLHFPSVVDMLHHFQRSPIPL 448
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 53.1 bits (126), Expect = 7e-07
Identities = 44/120 (36%), Positives = 58/120 (48%), Gaps = 16/120 (13%)
Query: 475 PQSVSMAEQLRGEPWFHGKLSRR-EAEALLQ--------LNGDFLVRESTTTPGQYVLTG 525
PQ + E GE WFH K+ +R AE LLQ +G FLVRES T P Y L+
Sbjct: 518 PQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSF 577
Query: 526 LQSGQPKHLLLVDP-EG----VVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPV 580
+SG+ +H + EG T + F S+ LI ++ + HL A EL L PV
Sbjct: 578 WRSGRVQHCRIRSTMEGGTLKYYLTDNLTFSSIYALIQHYRETHLR--CAEFELRLTDPV 635
Score = 37.0 bits (84), Expect = 0.050
Identities = 27/83 (32%), Positives = 42/83 (50%), Gaps = 5/83 (6%)
Query: 487 EPWFHGKLSRREAEALLQ---LNGDFLVRESTTTPGQYVLTGLQSGQPKHLLL-VDPEGV 542
+PW++ LSR EAE +L +G FL+R+ + Y +T G+ KH + D
Sbjct: 644 KPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGS-DSYAITFRARGKVKHCRINRDGRHF 702
Query: 543 VRTKDHRFESVSHLISYHMDNHL 565
V FES+ L+SY+ + L
Sbjct: 703 VLGTSAYFESLVELVSYYEKHSL 725
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 53.1 bits (126), Expect = 7e-07
Identities = 31/112 (27%), Positives = 55/112 (49%), Gaps = 7/112 (6%)
Query: 472 PPPPQS----VSMAEQLRGEPWFHGKLSRREAEALLQLNG---DFLVRESTTTPGQYVLT 524
P PPQ S+ + G PW++GK++R +AE L G DFL+R+S ++P + ++
Sbjct: 261 PSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVS 320
Query: 525 GLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCL 576
G+ KH + E V +F ++ L+ ++ + G +L L
Sbjct: 321 LKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAPIFTSEQGEKLYL 372
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 52.8 bits (125), Expect = 9e-07
Identities = 31/91 (34%), Positives = 49/91 (53%), Gaps = 4/91 (4%)
Query: 474 PPQSVSMAEQLRGEPWFHGKLSRREAEALLQ--LNGDFLVRESTTTPGQYVLTGLQSGQP 531
P ++ L W+HG +SR AE LL +NG FLVRES ++PGQ ++ G+
Sbjct: 143 PSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRV 202
Query: 532 KHLLL-VDPEG-VVRTKDHRFESVSHLISYH 560
H + +G V T + RF +++ L+ +H
Sbjct: 203 YHYRINTTADGKVYVTAESRFSTLAELVHHH 233
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 52.8 bits (125), Expect = 9e-07
Identities = 31/91 (34%), Positives = 49/91 (53%), Gaps = 4/91 (4%)
Query: 474 PPQSVSMAEQLRGEPWFHGKLSRREAEALLQ--LNGDFLVRESTTTPGQYVLTGLQSGQP 531
P ++ L W+HG +SR AE LL +NG FLVRES ++PGQ ++ G+
Sbjct: 158 PSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRV 217
Query: 532 KHLLL-VDPEG-VVRTKDHRFESVSHLISYH 560
H + +G V T + RF +++ L+ +H
Sbjct: 218 YHYRINTTADGKVYVTAESRFSTLAELVHHH 248
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.135 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,817,298
Number of Sequences: 37866
Number of extensions: 1811480
Number of successful extensions: 10242
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 102
Number of HSP's successfully gapped in prelim test: 430
Number of HSP's that attempted gapping in prelim test: 7854
Number of HSP's gapped (non-prelim): 2647
length of query: 584
length of database: 18,247,518
effective HSP length: 108
effective length of query: 476
effective length of database: 14,157,990
effective search space: 6739203240
effective search space used: 6739203240
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.