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Search of human proteins with 194018562
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194018562 histamine receptor H3 [Homo sapiens]
(445 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194018562 histamine receptor H3 [Homo sapiens] 913 0.0
gi|14251205 histamine H4 receptor isoform 1 [Homo sapiens] 266 4e-71
gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens] 218 9e-57
gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens] 193 3e-49
gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens] 186 3e-47
gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens] 186 3e-47
gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens] 186 3e-47
gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens] 186 3e-47
gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens] 186 3e-47
gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens] 186 3e-47
gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens] 186 3e-47
gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens] 186 3e-47
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens] 177 1e-44
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] 176 3e-44
gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens] 170 2e-42
gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens] 157 2e-38
gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens] 156 4e-38
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 153 3e-37
gi|32483397 dopamine receptor D4 [Homo sapiens] 152 6e-37
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 150 2e-36
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 150 2e-36
gi|4503385 dopamine receptor D2 isoform long [Homo sapiens] 149 4e-36
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 147 2e-35
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 137 2e-32
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 133 3e-31
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 123 4e-28
gi|219842331 histamine H4 receptor isoform 2 [Homo sapiens] 119 7e-27
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 113 4e-25
gi|149158709 histamine receptor H1 [Homo sapiens] 109 4e-24
gi|149158706 histamine receptor H1 [Homo sapiens] 109 4e-24
>gi|194018562 histamine receptor H3 [Homo sapiens]
Length = 445
Score = 913 bits (2360), Expect = 0.0
Identities = 445/445 (100%), Positives = 445/445 (100%)
Query: 1 MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV 60
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
Sbjct: 1 MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV 60
Query: 61 ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS 120
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
Sbjct: 61 ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS 120
Query: 121 SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG 180
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
Sbjct: 121 SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG 180
Query: 181 SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA 240
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
Sbjct: 181 SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA 240
Query: 241 GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV 300
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
Sbjct: 241 GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV 300
Query: 301 ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL 360
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
Sbjct: 301 ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL 360
Query: 361 AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR 420
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
Sbjct: 361 AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR 420
Query: 421 RAFTKLLCPQKLKIQPHSSLEHCWK 445
RAFTKLLCPQKLKIQPHSSLEHCWK
Sbjct: 421 RAFTKLLCPQKLKIQPHSSLEHCWK 445
>gi|14251205 histamine H4 receptor isoform 1 [Homo sapiens]
Length = 390
Score = 266 bits (679), Expect = 4e-71
Identities = 160/416 (38%), Positives = 215/416 (51%), Gaps = 63/416 (15%)
Query: 30 SAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIP 89
S + LA M+L+ A +LGNALV+LAFV D +LR ++++F LNLAISDF VG IP
Sbjct: 11 SLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIP 70
Query: 90 LYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDT 149
LY+P+ L W FG+ +C WL DYLLCT+S +NIVLISYDR+LSV+ AVSYR Q
Sbjct: 71 LYIPHTLF-EWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGV 129
Query: 150 RRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFT 209
+ V M+ VWVLAFL+ GP IL E S C FF WY L S LEF
Sbjct: 130 LKIVTLMVAVWVLAFLVNGPMILVSESWKDEGS----ECEPGFFSEWYILAITSFLEFVI 185
Query: 210 PFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEA 269
P + V +FN++IY W W++ H
Sbjct: 186 PVILVAYFNMNIY------------------------------------WSLWKRDHLSR 209
Query: 270 MPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSS-------SRGTERPRSLKR 322
H G A + + G G ++S S S S+ S R SL
Sbjct: 210 CQSH--------PGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMF 261
Query: 323 GSKPSASSASLEKRMKMVSQSFT------QRFRLSRDRKVAKSLAVIVSIFGLCWAPYTL 376
S+ +S ++ +M SQS + + L R R++AKSLA+++ +F +CWAPY+L
Sbjct: 262 SSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSL 321
Query: 377 LMIIRAACHGHCVP-DYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQK 431
I+ + P WY +FWL W NS VNP+LYPLCH F++AF K+ C +K
Sbjct: 322 FTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKK 377
>gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens]
Length = 460
Score = 218 bits (555), Expect = 9e-57
Identities = 131/414 (31%), Positives = 206/414 (49%), Gaps = 27/414 (6%)
Query: 35 AVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPY 94
A + LL +ATV GN LV+++F ++ L+T NN+FLL+LA +D ++G F + LY Y
Sbjct: 26 AFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTY 85
Query: 95 VLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVR 154
+L G W G C LWL +DY+ +S N++LIS+DR+ SVTR +SYRA++ RRA
Sbjct: 86 LLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKR-TPRRAAL 144
Query: 155 KMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSV 214
+ L W+++F+L+ PAIL W+YL G ++ G CY +F + F+ P +
Sbjct: 145 MIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVM 204
Query: 215 TFFNLSIYLNIQRRTRLRL----------DGAREAAGPEPPPEAQPSPPPPPG-CWGCWQ 263
IY + R R G ++ P A+ SP PPG C C +
Sbjct: 205 CTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCR 264
Query: 264 KGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGG---GGSV------ASPTSSSGSSSRGT 314
L Y E E +L G G V P + + +
Sbjct: 265 ----APRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPR 320
Query: 315 ERPRSLKRGSKPSASSASLEKRMKMVSQSFTQR-FRLSRDRKVAKSLAVIVSIFGLCWAP 373
P ++KR +K A ++ + Q ++ F L +++K A++L+ I+ F L W P
Sbjct: 321 SSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTP 380
Query: 374 YTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
Y +++++ C CVP+ +E +WL + NS +NP+ Y LC+ +FR F LL
Sbjct: 381 YNIMVLVSTFCK-DCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLL 433
>gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]
Length = 479
Score = 193 bits (490), Expect = 3e-49
Identities = 124/470 (26%), Positives = 227/470 (48%), Gaps = 52/470 (11%)
Query: 9 PLN-ASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRT 67
P+N +SG + + + +A + L + TV+GN LVML+ + L+T
Sbjct: 6 PVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQT 65
Query: 68 QNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVL 127
NN+FL +LA +D ++GAF + LY Y++ G W G +C LWL +DY++ +S N+++
Sbjct: 66 VNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLI 125
Query: 128 ISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGH 187
IS+DR+ VT+ ++Y A++ T+ A + WVL+F+L+ PAIL W+++ G ++P+
Sbjct: 126 ISFDRYFCVTKPLTYPARR-TTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQ 184
Query: 188 CYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRL---RLDGARE-----A 239
C+ +F N + F+ P + +T L I++++ R+R+ R +G +E
Sbjct: 185 CFIQFLSNPAVTFGTAIAAFYLPVVIMTV--LYIHISLASRSRVHKHRPEGPKEKKAKTL 242
Query: 240 AGPEPPPEAQPSPPPPPGCWGCWQKGHG---EAMPLHRYGVGEAAVGAEAGEATLGGGGG 296
A + P Q PPPG + +G EA P + + G
Sbjct: 243 AFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSAT 302
Query: 297 GGSVASPTSSSGSSSRGTE-------RPRSLKRGSKPS---------------------- 327
+ P + ++ T +PR+L S+ S
Sbjct: 303 QNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPA 362
Query: 328 -----ASSASLEKRMKMVSQSFTQRFR--LSRDRKVAKSLAVIVSIFGLCWAPYTLLMII 380
+A++ ++ ++++ ++ R +R+RKV +++ I+ F L W PY +++++
Sbjct: 363 TPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLV 422
Query: 381 RAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQ 430
C C+PD + +WL + NS +NP Y LC+ +F++ F LL Q
Sbjct: 423 NTFCQS-CIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQ 471
>gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 186 bits (473), Expect = 3e-47
Identities = 124/469 (26%), Positives = 221/469 (47%), Gaps = 68/469 (14%)
Query: 11 NASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNN 70
N++ + A + F + ++A ++L+ T++GN LVM++ + L+T NN
Sbjct: 3 NSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLV---TIIGNILVMVSIKVNRHLQTVNN 59
Query: 71 FFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISY 130
+FL +LA +D ++G F + LY Y + G W G +C LWL +DY++ +S N+++IS+
Sbjct: 60 YFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISF 119
Query: 131 DRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYA 190
DR+ VT+ ++Y ++ T+ A + WVL+F+L+ PAIL W+++ G ++ +G CY
Sbjct: 120 DRYFCVTKPLTYPVKR-TTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYI 178
Query: 191 EFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQP 250
+FF N + F+ P + +T +Y +I R ++ R+ ++ P A
Sbjct: 179 QFFSNAAVTFGTAIAAFYLPVIIMTV----LYWHISRASKSRIKKDKK------EPVANQ 228
Query: 251 SPPPPPGCWGCWQKGHGEAMPLHRYG---------------VGEAAVGAEAGEATLGGGG 295
P P G K + MP G V E V E E++
Sbjct: 229 DPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESS-NDST 287
Query: 296 GGGSVAS-------------PTSSSGSSSRGTERPRSLKRGSK-PSASSAS--------- 332
+VAS ++S G S + ++ G+K P + S +
Sbjct: 288 SVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVV 347
Query: 333 --------------LEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLM 378
K +KM Q ++ SR++KV +++ I+ F + WAPY +++
Sbjct: 348 GSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMV 407
Query: 379 IIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
+I C C+P+ + +WL + NS +NP Y LC+ +F++ F LL
Sbjct: 408 LINTFC-APCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 186 bits (473), Expect = 3e-47
Identities = 124/469 (26%), Positives = 221/469 (47%), Gaps = 68/469 (14%)
Query: 11 NASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNN 70
N++ + A + F + ++A ++L+ T++GN LVM++ + L+T NN
Sbjct: 3 NSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLV---TIIGNILVMVSIKVNRHLQTVNN 59
Query: 71 FFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISY 130
+FL +LA +D ++G F + LY Y + G W G +C LWL +DY++ +S N+++IS+
Sbjct: 60 YFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISF 119
Query: 131 DRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYA 190
DR+ VT+ ++Y ++ T+ A + WVL+F+L+ PAIL W+++ G ++ +G CY
Sbjct: 120 DRYFCVTKPLTYPVKR-TTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYI 178
Query: 191 EFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQP 250
+FF N + F+ P + +T +Y +I R ++ R+ ++ P A
Sbjct: 179 QFFSNAAVTFGTAIAAFYLPVIIMTV----LYWHISRASKSRIKKDKK------EPVANQ 228
Query: 251 SPPPPPGCWGCWQKGHGEAMPLHRYG---------------VGEAAVGAEAGEATLGGGG 295
P P G K + MP G V E V E E++
Sbjct: 229 DPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESS-NDST 287
Query: 296 GGGSVAS-------------PTSSSGSSSRGTERPRSLKRGSK-PSASSAS--------- 332
+VAS ++S G S + ++ G+K P + S +
Sbjct: 288 SVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVV 347
Query: 333 --------------LEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLM 378
K +KM Q ++ SR++KV +++ I+ F + WAPY +++
Sbjct: 348 GSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMV 407
Query: 379 IIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
+I C C+P+ + +WL + NS +NP Y LC+ +F++ F LL
Sbjct: 408 LINTFC-APCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 186 bits (473), Expect = 3e-47
Identities = 124/469 (26%), Positives = 221/469 (47%), Gaps = 68/469 (14%)
Query: 11 NASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNN 70
N++ + A + F + ++A ++L+ T++GN LVM++ + L+T NN
Sbjct: 3 NSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLV---TIIGNILVMVSIKVNRHLQTVNN 59
Query: 71 FFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISY 130
+FL +LA +D ++G F + LY Y + G W G +C LWL +DY++ +S N+++IS+
Sbjct: 60 YFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISF 119
Query: 131 DRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYA 190
DR+ VT+ ++Y ++ T+ A + WVL+F+L+ PAIL W+++ G ++ +G CY
Sbjct: 120 DRYFCVTKPLTYPVKR-TTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYI 178
Query: 191 EFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQP 250
+FF N + F+ P + +T +Y +I R ++ R+ ++ P A
Sbjct: 179 QFFSNAAVTFGTAIAAFYLPVIIMTV----LYWHISRASKSRIKKDKK------EPVANQ 228
Query: 251 SPPPPPGCWGCWQKGHGEAMPLHRYG---------------VGEAAVGAEAGEATLGGGG 295
P P G K + MP G V E V E E++
Sbjct: 229 DPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESS-NDST 287
Query: 296 GGGSVAS-------------PTSSSGSSSRGTERPRSLKRGSK-PSASSAS--------- 332
+VAS ++S G S + ++ G+K P + S +
Sbjct: 288 SVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVV 347
Query: 333 --------------LEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLM 378
K +KM Q ++ SR++KV +++ I+ F + WAPY +++
Sbjct: 348 GSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMV 407
Query: 379 IIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
+I C C+P+ + +WL + NS +NP Y LC+ +F++ F LL
Sbjct: 408 LINTFC-APCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 186 bits (473), Expect = 3e-47
Identities = 124/469 (26%), Positives = 221/469 (47%), Gaps = 68/469 (14%)
Query: 11 NASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNN 70
N++ + A + F + ++A ++L+ T++GN LVM++ + L+T NN
Sbjct: 3 NSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLV---TIIGNILVMVSIKVNRHLQTVNN 59
Query: 71 FFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISY 130
+FL +LA +D ++G F + LY Y + G W G +C LWL +DY++ +S N+++IS+
Sbjct: 60 YFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISF 119
Query: 131 DRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYA 190
DR+ VT+ ++Y ++ T+ A + WVL+F+L+ PAIL W+++ G ++ +G CY
Sbjct: 120 DRYFCVTKPLTYPVKR-TTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYI 178
Query: 191 EFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQP 250
+FF N + F+ P + +T +Y +I R ++ R+ ++ P A
Sbjct: 179 QFFSNAAVTFGTAIAAFYLPVIIMTV----LYWHISRASKSRIKKDKK------EPVANQ 228
Query: 251 SPPPPPGCWGCWQKGHGEAMPLHRYG---------------VGEAAVGAEAGEATLGGGG 295
P P G K + MP G V E V E E++
Sbjct: 229 DPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESS-NDST 287
Query: 296 GGGSVAS-------------PTSSSGSSSRGTERPRSLKRGSK-PSASSAS--------- 332
+VAS ++S G S + ++ G+K P + S +
Sbjct: 288 SVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVV 347
Query: 333 --------------LEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLM 378
K +KM Q ++ SR++KV +++ I+ F + WAPY +++
Sbjct: 348 GSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMV 407
Query: 379 IIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
+I C C+P+ + +WL + NS +NP Y LC+ +F++ F LL
Sbjct: 408 LINTFC-APCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 186 bits (473), Expect = 3e-47
Identities = 124/469 (26%), Positives = 221/469 (47%), Gaps = 68/469 (14%)
Query: 11 NASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNN 70
N++ + A + F + ++A ++L+ T++GN LVM++ + L+T NN
Sbjct: 3 NSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLV---TIIGNILVMVSIKVNRHLQTVNN 59
Query: 71 FFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISY 130
+FL +LA +D ++G F + LY Y + G W G +C LWL +DY++ +S N+++IS+
Sbjct: 60 YFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISF 119
Query: 131 DRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYA 190
DR+ VT+ ++Y ++ T+ A + WVL+F+L+ PAIL W+++ G ++ +G CY
Sbjct: 120 DRYFCVTKPLTYPVKR-TTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYI 178
Query: 191 EFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQP 250
+FF N + F+ P + +T +Y +I R ++ R+ ++ P A
Sbjct: 179 QFFSNAAVTFGTAIAAFYLPVIIMTV----LYWHISRASKSRIKKDKK------EPVANQ 228
Query: 251 SPPPPPGCWGCWQKGHGEAMPLHRYG---------------VGEAAVGAEAGEATLGGGG 295
P P G K + MP G V E V E E++
Sbjct: 229 DPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESS-NDST 287
Query: 296 GGGSVAS-------------PTSSSGSSSRGTERPRSLKRGSK-PSASSAS--------- 332
+VAS ++S G S + ++ G+K P + S +
Sbjct: 288 SVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVV 347
Query: 333 --------------LEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLM 378
K +KM Q ++ SR++KV +++ I+ F + WAPY +++
Sbjct: 348 GSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMV 407
Query: 379 IIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
+I C C+P+ + +WL + NS +NP Y LC+ +F++ F LL
Sbjct: 408 LINTFC-APCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 186 bits (473), Expect = 3e-47
Identities = 124/469 (26%), Positives = 221/469 (47%), Gaps = 68/469 (14%)
Query: 11 NASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNN 70
N++ + A + F + ++A ++L+ T++GN LVM++ + L+T NN
Sbjct: 3 NSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLV---TIIGNILVMVSIKVNRHLQTVNN 59
Query: 71 FFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISY 130
+FL +LA +D ++G F + LY Y + G W G +C LWL +DY++ +S N+++IS+
Sbjct: 60 YFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISF 119
Query: 131 DRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYA 190
DR+ VT+ ++Y ++ T+ A + WVL+F+L+ PAIL W+++ G ++ +G CY
Sbjct: 120 DRYFCVTKPLTYPVKR-TTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYI 178
Query: 191 EFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQP 250
+FF N + F+ P + +T +Y +I R ++ R+ ++ P A
Sbjct: 179 QFFSNAAVTFGTAIAAFYLPVIIMTV----LYWHISRASKSRIKKDKK------EPVANQ 228
Query: 251 SPPPPPGCWGCWQKGHGEAMPLHRYG---------------VGEAAVGAEAGEATLGGGG 295
P P G K + MP G V E V E E++
Sbjct: 229 DPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESS-NDST 287
Query: 296 GGGSVAS-------------PTSSSGSSSRGTERPRSLKRGSK-PSASSAS--------- 332
+VAS ++S G S + ++ G+K P + S +
Sbjct: 288 SVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVV 347
Query: 333 --------------LEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLM 378
K +KM Q ++ SR++KV +++ I+ F + WAPY +++
Sbjct: 348 GSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMV 407
Query: 379 IIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
+I C C+P+ + +WL + NS +NP Y LC+ +F++ F LL
Sbjct: 408 LINTFC-APCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 186 bits (473), Expect = 3e-47
Identities = 124/469 (26%), Positives = 221/469 (47%), Gaps = 68/469 (14%)
Query: 11 NASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNN 70
N++ + A + F + ++A ++L+ T++GN LVM++ + L+T NN
Sbjct: 3 NSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLV---TIIGNILVMVSIKVNRHLQTVNN 59
Query: 71 FFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISY 130
+FL +LA +D ++G F + LY Y + G W G +C LWL +DY++ +S N+++IS+
Sbjct: 60 YFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISF 119
Query: 131 DRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYA 190
DR+ VT+ ++Y ++ T+ A + WVL+F+L+ PAIL W+++ G ++ +G CY
Sbjct: 120 DRYFCVTKPLTYPVKR-TTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYI 178
Query: 191 EFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQP 250
+FF N + F+ P + +T +Y +I R ++ R+ ++ P A
Sbjct: 179 QFFSNAAVTFGTAIAAFYLPVIIMTV----LYWHISRASKSRIKKDKK------EPVANQ 228
Query: 251 SPPPPPGCWGCWQKGHGEAMPLHRYG---------------VGEAAVGAEAGEATLGGGG 295
P P G K + MP G V E V E E++
Sbjct: 229 DPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESS-NDST 287
Query: 296 GGGSVAS-------------PTSSSGSSSRGTERPRSLKRGSK-PSASSAS--------- 332
+VAS ++S G S + ++ G+K P + S +
Sbjct: 288 SVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVV 347
Query: 333 --------------LEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLM 378
K +KM Q ++ SR++KV +++ I+ F + WAPY +++
Sbjct: 348 GSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMV 407
Query: 379 IIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
+I C C+P+ + +WL + NS +NP Y LC+ +F++ F LL
Sbjct: 408 LINTFC-APCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 186 bits (473), Expect = 3e-47
Identities = 124/469 (26%), Positives = 221/469 (47%), Gaps = 68/469 (14%)
Query: 11 NASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNN 70
N++ + A + F + ++A ++L+ T++GN LVM++ + L+T NN
Sbjct: 3 NSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLV---TIIGNILVMVSIKVNRHLQTVNN 59
Query: 71 FFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISY 130
+FL +LA +D ++G F + LY Y + G W G +C LWL +DY++ +S N+++IS+
Sbjct: 60 YFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISF 119
Query: 131 DRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYA 190
DR+ VT+ ++Y ++ T+ A + WVL+F+L+ PAIL W+++ G ++ +G CY
Sbjct: 120 DRYFCVTKPLTYPVKR-TTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYI 178
Query: 191 EFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQP 250
+FF N + F+ P + +T +Y +I R ++ R+ ++ P A
Sbjct: 179 QFFSNAAVTFGTAIAAFYLPVIIMTV----LYWHISRASKSRIKKDKK------EPVANQ 228
Query: 251 SPPPPPGCWGCWQKGHGEAMPLHRYG---------------VGEAAVGAEAGEATLGGGG 295
P P G K + MP G V E V E E++
Sbjct: 229 DPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESS-NDST 287
Query: 296 GGGSVAS-------------PTSSSGSSSRGTERPRSLKRGSK-PSASSAS--------- 332
+VAS ++S G S + ++ G+K P + S +
Sbjct: 288 SVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVV 347
Query: 333 --------------LEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLM 378
K +KM Q ++ SR++KV +++ I+ F + WAPY +++
Sbjct: 348 GSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMV 407
Query: 379 IIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
+I C C+P+ + +WL + NS +NP Y LC+ +F++ F LL
Sbjct: 408 LINTFC-APCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
Length = 462
Score = 177 bits (450), Expect = 1e-44
Identities = 140/456 (30%), Positives = 214/456 (46%), Gaps = 56/456 (12%)
Query: 8 GPLNASGALAGEAAAAGGARGFSAAW-----------TAVLAALMALLIVATVLGNALVM 56
GP NASGA GE + G A A+W A LAA++ LIV TV+GN LV+
Sbjct: 17 GP-NASGA--GERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVV 73
Query: 57 LAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYL 116
+A + +LR N FL++LA +D LV +P + L W FG+ C ++L +D L
Sbjct: 74 IAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVL 133
Query: 117 LCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEY 176
CTSS ++ IS DR+ SVT+AV Y ++ RR ++ VW+++ ++ P ++S
Sbjct: 134 FCTSSIVHLCAISLDRYWSVTQAVEYNLKR-TPRRVKATIVAVWLISAVISFPPLVSLYR 192
Query: 177 LSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGA 236
G++ P+ E WY ++++ FF P L + +Y I R +LR
Sbjct: 193 QPDGAAYPQCGLNDE---TWY-ILSSCIGSFFAPCLIMGL----VYARIYRVAKLRTRTL 244
Query: 237 REAAGPEPPPEAQPSPPPPPG-CWGCWQKGHGEAMPL--------------HRYGV---- 277
E P P A P+ G G + GH P R G
Sbjct: 245 SEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRG 304
Query: 278 GEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSAS--LEK 335
G GAE G GG G A P ++ + + P R S+ S+ S L +
Sbjct: 305 GRRRAGAEG-----GAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSR 359
Query: 336 RMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAP----YTLLMIIRAACHGHCVPD 391
R + S ++ +R+++ LAV++ +F LCW P Y+L I R AC VP
Sbjct: 360 RRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQ---VPG 416
Query: 392 YWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
++ FW+ + NS++NPV+Y + + FRR+F +L
Sbjct: 417 PLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHIL 452
>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
Length = 465
Score = 176 bits (447), Expect = 3e-44
Identities = 130/441 (29%), Positives = 202/441 (45%), Gaps = 43/441 (9%)
Query: 18 GEAAAAGGARG--FSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLN 75
G A GGAR +S T L L LL++ TV GN LV++A +L+ N FL++
Sbjct: 30 GTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVS 89
Query: 76 LAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLS 135
LA +D LV IP + + G W FG+ C+++L +D L CTSS ++ IS DR+ S
Sbjct: 90 LASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWS 149
Query: 136 VTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYN 195
+T+A+ Y ++ RR ++ VWV++ ++ P ++S E GG E
Sbjct: 150 ITQAIEYNLKR-TPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQ 208
Query: 196 WYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRL--RLDGAREAAGPEPPPEAQPSPP 253
+++I++ FF P L + + IY +RRTR+ G A P E +P+
Sbjct: 209 KWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGL 268
Query: 254 PPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRG 313
P G G EA PL + GE G ++ SSS +
Sbjct: 269 GPERSAG---PGGAEAEPL------PTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAER 319
Query: 314 TERPRSLKRGSK--------------------PSASSASL------EKRMKMVSQSFTQR 347
PR +RG + P A+ E+R+ S R
Sbjct: 320 PPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKAS-RWR 378
Query: 348 FRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAV 407
R +R+++ LAV++ +F +CW P+ + A G VP ++ FW + NS++
Sbjct: 379 GRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV--GCSVPRTLFKFFFWFGYCNSSL 436
Query: 408 NPVLYPLCHHSFRRAFTKLLC 428
NPV+Y + +H FRRAF K+LC
Sbjct: 437 NPVIYTIFNHDFRRAFKKILC 457
>gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]
Length = 450
Score = 170 bits (431), Expect = 2e-42
Identities = 129/443 (29%), Positives = 200/443 (45%), Gaps = 50/443 (11%)
Query: 29 FSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCI 88
+S TA +AA + LI+ T+ GNALV+LA + SLR N FL++LA +D LV I
Sbjct: 7 YSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLII 66
Query: 89 PLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGD 148
P + L G W F R C+++L +D L CTSS ++ IS DR+ +V+RA+ Y +++
Sbjct: 67 PFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKR-T 125
Query: 149 TRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFF 208
RR +L VW++A ++ P ++ Y P G + ++++ +S FF
Sbjct: 126 PRRIKCIILTVWLIAAVISLPPLI---YKGDQGPQPRGRPQCKLNQEAWYILASSIGSFF 182
Query: 209 TPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSP-----------PPPPG 257
P L + L IYL +R R G R GP QP P P
Sbjct: 183 APCLIMILVYLRIYLIAKRSNR---RGPRAKGGPGQGESKQPRPDHGGALASAKLPALAS 239
Query: 258 CWGCWQ-KGHGEAMPLHRYGVGEAAVGAEA---GEATLGGGGGGGSV----ASPTSSSGS 309
+ GH ++ G G A A L G G ASP +
Sbjct: 240 VASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEE 299
Query: 310 SSRGTERPRSLKRGSKP----SASSASLEKRM-------------------KMVSQSFTQ 346
E + + P SA S L++ + Q + +
Sbjct: 300 EEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRR 359
Query: 347 RFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHC-VPDYWYETSFWLLWANS 405
R +L+R+++ LAV++ +F LCW P+ + A C HC VP ++ FW+ + NS
Sbjct: 360 RAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNS 419
Query: 406 AVNPVLYPLCHHSFRRAFTKLLC 428
++NPV+Y + + FRRAF ++LC
Sbjct: 420 SLNPVIYTIFNQDFRRAFRRILC 442
>gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens]
Length = 590
Score = 157 bits (396), Expect = 2e-38
Identities = 80/237 (33%), Positives = 133/237 (56%), Gaps = 4/237 (1%)
Query: 12 ASGALAGEAAAAGGARGFSAAWTAV-LAALMALLIVATVLGNALVMLAFVADSSLRTQNN 70
A+G + G W V +A L +L + T++GN LV+++F + L+T NN
Sbjct: 45 AAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNN 104
Query: 71 FFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISY 130
+FLL+LA +D ++G + L+ Y++ RW G C LWL +DY+ +S N+++IS+
Sbjct: 105 YFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISF 164
Query: 131 DRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYA 190
DR+ S+TR ++YRA++ T+RA + L WV++F+L+ PAIL W+Y G ++P G C+
Sbjct: 165 DRYFSITRPLTYRAKR-TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFI 223
Query: 191 EFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPE 247
+F + F+ P +T IY ++RT+ L G +A+G E E
Sbjct: 224 QFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTK-ELAGL-QASGTEAETE 278
Score = 75.5 bits (184), Expect = 9e-14
Identities = 38/107 (35%), Positives = 64/107 (59%), Gaps = 4/107 (3%)
Query: 327 SASSASLEKRMKMVSQS-FTQRFRLS--RDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAA 383
S A+L KR + ++S T+R R+S +++K A++L+ I+ F + W PY +++++
Sbjct: 457 SFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTF 516
Query: 384 CHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQ 430
C C+P ++ +WL + NS VNPV Y LC+ +FR F LL Q
Sbjct: 517 CDS-CIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQ 562
>gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens]
Length = 532
Score = 156 bits (394), Expect = 4e-38
Identities = 73/199 (36%), Positives = 123/199 (61%), Gaps = 2/199 (1%)
Query: 33 WTAV-LAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLY 91
W + +AA+ A++ + T++GN LVM++F +S L+T NN++LL+LA +D ++G F + LY
Sbjct: 28 WEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLY 87
Query: 92 VPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRR 151
Y+L GRW G C LWL +DY+ +S N+++IS+DR+ S+TR ++YRA++ +R
Sbjct: 88 TTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKR-TPKR 146
Query: 152 AVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPF 211
A + L W+++F+L+ PAIL W+YL G ++P C +F + F+ P
Sbjct: 147 AGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPV 206
Query: 212 LSVTFFNLSIYLNIQRRTR 230
+T IY ++RT+
Sbjct: 207 SVMTILYCRIYRETEKRTK 225
Score = 71.2 bits (173), Expect = 2e-12
Identities = 39/111 (35%), Positives = 60/111 (54%), Gaps = 4/111 (3%)
Query: 326 PSASSASLEKRMKMVSQSFTQRFR--LSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAA 383
P A S + S T+R R L ++RK A++L+ I+ F + W PY +++++
Sbjct: 408 PVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTF 467
Query: 384 CHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTK-LLCPQKLK 433
C CVP + +WL + NS VNP+ Y LC+ +FR+ F LLC K K
Sbjct: 468 CD-KCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKK 517
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 153 bits (387), Expect = 3e-37
Identities = 127/440 (28%), Positives = 190/440 (43%), Gaps = 87/440 (19%)
Query: 6 PDGPLNASGALAGEAAAAG-------GARGFSAAWTAVLAALMALLIVATVLGNALVMLA 58
PDG A+ L + A S WTA + LMAL+++ V GN LV++A
Sbjct: 23 PDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVA 82
Query: 59 FVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLC 118
L+T N F+++LA +D ++G +P V+ GRW +G C+LW VD L
Sbjct: 83 IAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCV 142
Query: 119 TSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKML-LVWVLAFLL-YGPAILSWEY 176
T+S + +I+ DR+L++T +R Q TR R ++ VW ++ L+ + P ++ W
Sbjct: 143 TASIETLCVIALDRYLAITS--PFRYQSLLTRARARGLVCTVWAISALVSFLPILMHW-- 198
Query: 177 LSGGSSIPEGHCY-----AEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRL 231
S CY +F N + I +S + F+ P + F L ++ Q++ +
Sbjct: 199 -WRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVK- 256
Query: 232 RLDGA--REAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEA 289
++D R GP PP PSP P P A P G A A A
Sbjct: 257 KIDSCERRFLGGPARPPSPSPSPVPAP------------APP-----PGPPRPAAAAATA 299
Query: 290 TLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFR 349
L G G KR +PS A E
Sbjct: 300 PLANGRAG-----------------------KR--RPSRLVALRE--------------- 319
Query: 350 LSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNP 409
+K K+L +I+ +F LCW P+ L +++ A H VPD + WL +ANSA NP
Sbjct: 320 ----QKALKTLGIIMGVFTLCWLPFFLANVVK-AFHRELVPDRLFVFFNWLGYANSAFNP 374
Query: 410 VLYPLCHH-SFRRAFTKLLC 428
++Y C FR+AF LLC
Sbjct: 375 IIY--CRSPDFRKAFQGLLC 392
>gi|32483397 dopamine receptor D4 [Homo sapiens]
Length = 419
Score = 152 bits (384), Expect = 6e-37
Identities = 119/427 (27%), Positives = 191/427 (44%), Gaps = 29/427 (6%)
Query: 11 NASGALAGEAAAAGGARGFSAAWTAVLAALMA---LLIVATVLGNALVMLAFVADSSLRT 67
+A G LAG AAG + G SA AA + LLI A + GN+LV ++ + +L+T
Sbjct: 8 DADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQT 67
Query: 68 QNNFFLLNLAISDFLVGAFCIPLYV-PYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIV 126
N F+++LA +D L+ +PL+V V G W LC + +D +LCT+S FN+
Sbjct: 68 PTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLC 127
Query: 127 LISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEG 186
IS DRF++V + Y +QG +RR + + W+L+ + P + + G
Sbjct: 128 AISVDRFVAVAVPLRYN-RQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAV-- 184
Query: 187 HCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQR-----RTRLRLDGAREAAG 241
C E + +++ +S FF P + + + +QR R +L R +G
Sbjct: 185 -CRLE---DRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG 240
Query: 242 PEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVA 301
P PP P+P P G +P G A + G +
Sbjct: 241 PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPG 300
Query: 302 SPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLS-RDRKVAKSL 360
P GS+ P +++ + P + +R +R +++ R+RK + L
Sbjct: 301 LPPDPCGSNCAP---PDAVRAAALPPQTPPQTRRR---------RRAKITGRERKAMRVL 348
Query: 361 AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR 420
V+V F LCW P+ ++ I +A C VP WL + NSA+NPV+Y + + FR
Sbjct: 349 PVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFR 408
Query: 421 RAFTKLL 427
F K L
Sbjct: 409 NVFRKAL 415
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 150 bits (380), Expect = 2e-36
Identities = 110/408 (26%), Positives = 190/408 (46%), Gaps = 24/408 (5%)
Query: 25 GARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVG 84
G + ++ + + L+ LI VLGNA V+ A + SL+ N+ + +LA++D +V
Sbjct: 27 GISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVS 86
Query: 85 AFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRA 144
+P+ Y + +WT G+ C L++ +D L CTSS ++ I+ DR+ ++T + Y
Sbjct: 87 VLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDY-V 145
Query: 145 QQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITAST 204
+ RRA + L W++ FL+ P +L W S + Y Y A
Sbjct: 146 NKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGA-- 203
Query: 205 LEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGA---REAAGPEPPPEAQPSPPPPPGCWGC 261
F+ P L + L +Y I R R R+ E G + A P+P P
Sbjct: 204 --FYIPLLLM----LVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPK------ 251
Query: 262 WQKGHGEAMPLH-RYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSL 320
+ +GE+ + R GV A GA + G G ++ +S+ P
Sbjct: 252 -KSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSK-EHLPLPS 309
Query: 321 KRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMII 380
+ G P A AS E++ + +++ ++ L+R+RK K+L +I+ F LCW P+ ++ ++
Sbjct: 310 EAGPTPCA-PASFERKNERNAEA-KRKMALARERKTVKTLGIIMGTFILCWLPFFIVALV 367
Query: 381 RAACHGHC-VPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
C C +P WL ++NS +NPV+Y + F+ AF K++
Sbjct: 368 LPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII 415
>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
Length = 414
Score = 150 bits (379), Expect = 2e-36
Identities = 104/409 (25%), Positives = 185/409 (45%), Gaps = 53/409 (12%)
Query: 38 AALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLT 97
A L+ LLI V GN LV +A + +L+T N+ +++LA++D LV +P V +
Sbjct: 38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 97
Query: 98 GRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKML 157
G W F R C +++ +D ++CT+S N+ IS DR+ +V + Y + RR +
Sbjct: 98 GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 157
Query: 158 LVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFF 217
+VWVL+F + P + G ++ + C N F++ +S + F+ PF+
Sbjct: 158 IVWVLSFTISCPLLF------GLNNADQNEC---IIANPAFVVYSSIVSFYVPFIVTLLV 208
Query: 218 NLSIYLNIQRRTR--------------LRL---DGAREAAGPEPPPEAQPSPPPPPGCWG 260
+ IY+ ++RR + LR + AR A E + SPP
Sbjct: 209 YIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPE------ 262
Query: 261 CWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRG--TERPR 318
+ + P H + TL G ++P S + G + P+
Sbjct: 263 --RTRYSPIPPSHH-------------QLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPK 307
Query: 319 SLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLM 378
K + + +K +S+ ++ +++K + LA+++ +F +CW P+ +
Sbjct: 308 IAKIFEIQTMPNGKTRTSLKTMSR---RKLSQQKEKKATQMLAIVLGVFIICWLPFFITH 364
Query: 379 IIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
I+ C + +P Y WL + NSAVNP++Y + FR+AF K+L
Sbjct: 365 ILNIHCDCN-IPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 412
>gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]
Length = 443
Score = 149 bits (377), Expect = 4e-36
Identities = 110/420 (26%), Positives = 193/420 (45%), Gaps = 46/420 (10%)
Query: 38 AALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLT 97
A L+ LLI V GN LV +A + +L+T N+ +++LA++D LV +P V +
Sbjct: 38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 97
Query: 98 GRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKML 157
G W F R C +++ +D ++CT+S N+ IS DR+ +V + Y + RR +
Sbjct: 98 GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 157
Query: 158 LVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFF 217
+VWVL+F + P L G ++ + C N F++ +S + F+ PF+
Sbjct: 158 IVWVLSFTISCP------LLFGLNNADQNEC---IIANPAFVVYSSIVSFYVPFIVTLLV 208
Query: 218 NLSIYLNIQRRTRLRLDGAREA----AGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLH 273
+ IY+ + RR R R++ R + A P + + P K +G + P++
Sbjct: 209 YIKIYI-VLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNG-SFPVN 266
Query: 274 RYGVGEAAVGAEAGE------------------------ATLGGGGGGGSVASPTSSSGS 309
R V EAA A+ E TL G ++P S +
Sbjct: 267 RRRV-EAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKP 325
Query: 310 SSRG--TERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIF 367
G + P+ K + + +K +S+ ++ +++K + LA+++ +F
Sbjct: 326 EKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR---RKLSQQKEKKATQMLAIVLGVF 382
Query: 368 GLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
+CW P+ + I+ C + +P Y WL + NSAVNP++Y + FR+AF K+L
Sbjct: 383 IICWLPFFITHILNIHCDCN-IPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 441
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 147 bits (370), Expect = 2e-35
Identities = 107/435 (24%), Positives = 182/435 (41%), Gaps = 82/435 (18%)
Query: 12 ASGALAGEAAAAGGARGFSAAWTAVLAA-------LMALLIVATVLGNALVMLAFVADSS 64
+S G A A G G +A V++A +A I+ V GN LV+L+ +
Sbjct: 67 SSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRH 126
Query: 65 LRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFN 124
L+T N+F++NLA++D L+ A +P + G W FGR C +W VD L CT+S +
Sbjct: 127 LQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILS 186
Query: 125 IVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIP 184
+ IS DR++ V ++ Y A + R+A + L+WV+A ++ +L W+ +P
Sbjct: 187 LCTISVDRYVGVRHSLKYPAIMTE-RKAAAILALLWVVALVVSVGPLLGWK-----EPVP 240
Query: 185 EGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEP 244
+ + + +S F+ P + +Y+ + TR G + G
Sbjct: 241 PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERG--- 297
Query: 245 PPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPT 304
K + +H G A GA
Sbjct: 298 -------------------KASEVVLRIHCRGAATGADGAHG------------------ 320
Query: 305 SSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIV 364
R +K +SL R+ + SR++K AK+LA++V
Sbjct: 321 ----------------MRSAKGHTFRSSLSVRL----------LKFSREKKAAKTLAIVV 354
Query: 365 SIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFT 424
+F LCW P+ ++ + + + ++ FWL + NS VNP++YP F+RAF
Sbjct: 355 GVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFL 414
Query: 425 KLL---CPQKLKIQP 436
+LL C ++ + +P
Sbjct: 415 RLLRCQCRRRRRRRP 429
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 137 bits (345), Expect = 2e-32
Identities = 120/432 (27%), Positives = 189/432 (43%), Gaps = 60/432 (13%)
Query: 16 LAGEAAAAGGARGFSAAWTAVLAALMAL----LIVATVLGNALVMLAFVADSSLRTQNNF 71
L+G GA + A A A AL LI+A V GN LV +A + + +L+T N+
Sbjct: 7 LSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNY 66
Query: 72 FLLNLAISDFLVGAFCIPLYVPYVLTGR-WTFGRGLCKLWLVVDYLLCTSSAFNIVLISY 130
+++LA++D LV +P V +TG W F R C +++ +D ++CT+S N+ IS
Sbjct: 67 LVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISI 126
Query: 131 DRFLSVTRAVSYR--AQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHC 188
DR+ +V V Y+ Q RR + VWVLAF + P + + +G ++
Sbjct: 127 DRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFN-TTGDPTVCS--- 182
Query: 189 YAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLR-LDGAREAAGPEPPPE 247
N F+I +S + F+ PF IY+ +++R R R L P
Sbjct: 183 ----ISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGF 238
Query: 248 AQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSS 307
Q + P P + L RY + + LGG
Sbjct: 239 PQQTLSPDPA-----------HLELKRY-------YSICQDTALGG-------------P 267
Query: 308 GSSSRGTERPRSLKRGSKPS---ASSASLEKRMKMVSQSFTQRFRLS---------RDRK 355
G RG E R K + S A SLE R K+ + + +L R++K
Sbjct: 268 GFQERGGELKREEKTRNSLSPTIAPKLSLEVR-KLSNGRLSTSLKLGPLQPRGVPLREKK 326
Query: 356 VAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLC 415
+ +A+++ F +CW P+ L ++ C V Y + WL + NSA+NPV+Y
Sbjct: 327 ATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTF 386
Query: 416 HHSFRRAFTKLL 427
+ FR+AF K+L
Sbjct: 387 NIEFRKAFLKIL 398
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 133 bits (335), Expect = 3e-31
Identities = 115/420 (27%), Positives = 179/420 (42%), Gaps = 69/420 (16%)
Query: 16 LAGEAAAAGGARGFSAAWTAVLAALMAL----LIVATVLGNALVMLAFVADSSLRTQNNF 71
L+G GA + A A A AL LI+A V GN LV +A + + +L+T N+
Sbjct: 7 LSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNY 66
Query: 72 FLLNLAISDFLVGAFCIPLYVPYVLTGR-WTFGRGLCKLWLVVDYLLCTSSAFNIVLISY 130
+++LA++D LV +P V +TG W F R C +++ +D ++CT+S N+ IS
Sbjct: 67 LVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISI 126
Query: 131 DRFLSVTRAVSYR--AQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHC 188
DR+ +V V Y+ Q RR + VWVLAF + P + + +G ++
Sbjct: 127 DRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFN-TTGDPTVCS--- 182
Query: 189 YAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLR-LDGAREAAGPEPPPE 247
N F+I +S + F+ PF IY+ +++R R R L P
Sbjct: 183 ----ISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGF 238
Query: 248 AQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSS 307
Q + P P + L RY + + LGG G
Sbjct: 239 PQQTLSPDPA-----------HLELKRY-------YSICQDTALGGPG------------ 268
Query: 308 GSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIF 367
ER LKR K S L R++K + +A+++ F
Sbjct: 269 -----FQERGGELKREEKTRNSLMPL------------------REKKATQMVAIVLGAF 305
Query: 368 GLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
+CW P+ L ++ C V Y + WL + NSA+NPV+Y + FR+AF K+L
Sbjct: 306 IVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 365
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 123 bits (308), Expect = 4e-28
Identities = 98/395 (24%), Positives = 173/395 (43%), Gaps = 68/395 (17%)
Query: 37 LAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVL 96
LA +++++ +ATVL NA V+ + L T N+ + +LA +D LV +P+ + Y +
Sbjct: 41 LAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTI 100
Query: 97 TGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKM 156
T W FG+ LC +WL D CT+S ++ +I+ DR+ ++T A+ Y +++ A +
Sbjct: 101 THTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEY-SKRRTAGHAATMI 159
Query: 157 LLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTF 216
+VW ++ + P L W + + C Y I ++ F+ P + +
Sbjct: 160 AIVWAISICISIPP-LFWRQAKAQEEMSD--CLVNTSQISY-TIYSTCGAFYIPSVLL-- 213
Query: 217 FNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYG 276
+ +Y I R R R+ +PP
Sbjct: 214 --IILYGRIYRAARNRI----------------LNPP----------------------- 232
Query: 277 VGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKR 336
+ G A L G G S+ S S SL G SA S
Sbjct: 233 ---SLYGKRFTTAHLITGSAGSSLCSLNS-------------SLHEGHSHSAGSPLFFNH 276
Query: 337 MKM-VSQSFTQRFRLS--RDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHC-VPDY 392
+K+ ++ S +R R+S R+RK K L +I+ F +CW P+ ++ ++ C C +
Sbjct: 277 VKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPA 336
Query: 393 WYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
++ WL + NS +NP++Y + + FR+AF K++
Sbjct: 337 LFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
>gi|219842331 histamine H4 receptor isoform 2 [Homo sapiens]
Length = 302
Score = 119 bits (297), Expect = 7e-27
Identities = 78/258 (30%), Positives = 112/258 (43%), Gaps = 58/258 (22%)
Query: 188 CYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPE 247
C FF WY L S LEF P + V +FN++IY
Sbjct: 76 CEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIY------------------------- 110
Query: 248 AQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSS 307
W W++ H H G A + + G G ++S S S
Sbjct: 111 -----------WSLWKRDHLSRCQSHP--------GLTAVSSNICGHSFRGRLSSRRSLS 151
Query: 308 GSS-------SRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFT------QRFRLSRDR 354
S+ S R SL S+ +S ++ +M SQS + + L R R
Sbjct: 152 ASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRAR 211
Query: 355 KVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVP-DYWYETSFWLLWANSAVNPVLYP 413
++AKSLA+++ +F +CWAPY+L I+ + P WY +FWL W NS VNP+LYP
Sbjct: 212 RLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYP 271
Query: 414 LCHHSFRRAFTKLLCPQK 431
LCH F++AF K+ C +K
Sbjct: 272 LCHKRFQKAFLKIFCIKK 289
Score = 56.6 bits (135), Expect = 4e-08
Identities = 29/54 (53%), Positives = 39/54 (72%)
Query: 30 SAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLV 83
S + LA M+L+ A +LGNALV+LAFV D +LR ++++F LNLAISDF V
Sbjct: 11 SLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFV 64
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 113 bits (282), Expect = 4e-25
Identities = 83/254 (32%), Positives = 126/254 (49%), Gaps = 21/254 (8%)
Query: 16 LAGEAAAAGGARGFSAAWTAVLA-ALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLL 74
LA A G G W A LA AL+AL ++ATV GN LV++A L+T N F+
Sbjct: 20 LAPNTANTSGLPG--VPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVT 77
Query: 75 NLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFL 134
+LA +D ++G +P LTG W G C+LW VD L T+S + ++ DR+L
Sbjct: 78 SLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYL 137
Query: 135 SVTRAVSYRAQQGDTRRAVR-KMLLVWVL-AFLLYGPAILSWEYLSGGSSIPEGH----C 188
+VT + Y A T+R R ++LVWV+ A + + P + W + + H C
Sbjct: 138 AVTNPLRYGALV--TKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRC 195
Query: 189 YAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEA 248
A F N +++ +S++ F+ P L + F +++ R+ RL R G PP E+
Sbjct: 196 CA-FASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRL----LRGELGRFPPEES 250
Query: 249 QPSP-----PPPPG 257
P+P P P G
Sbjct: 251 PPAPSRSLAPAPVG 264
Score = 54.3 bits (129), Expect = 2e-07
Identities = 31/86 (36%), Positives = 46/86 (53%), Gaps = 3/86 (3%)
Query: 352 RDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVL 411
R+ + +L +I+ F LCW P+ L ++RA VP + WL +ANSA NP++
Sbjct: 286 REHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLI 345
Query: 412 YPLCHH-SFRRAFTKLLCPQKLKIQP 436
Y C FR AF +LLC ++ P
Sbjct: 346 Y--CRSPDFRSAFRRLLCRCGRRLPP 369
>gi|149158709 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 109 bits (273), Expect = 4e-24
Identities = 62/221 (28%), Positives = 116/221 (52%), Gaps = 3/221 (1%)
Query: 13 SGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFF 72
S L + G ++ L +++ + + TV N LV+ A ++ L T N +
Sbjct: 6 SSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLY 65
Query: 73 LLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDR 132
+++L+++D +VGA +P+ + Y+L +W+ GR LC WL +DY+ T+S F++ ++ DR
Sbjct: 66 IVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDR 125
Query: 133 FLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSI-PEGHCYAE 191
+ SV + + Y + T RA +L W L+FL P IL W + +S+ E C +
Sbjct: 126 YRSVQQPLRYLKYRTKT-RASATILGAWFLSFLWVIP-ILGWNHFMQQTSVRREDKCETD 183
Query: 192 FFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLR 232
F+ +F + + + F+ P L + +F IY +++ + R
Sbjct: 184 FYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHR 224
Score = 78.6 bits (192), Expect = 1e-14
Identities = 36/112 (32%), Positives = 66/112 (58%), Gaps = 7/112 (6%)
Query: 322 RGSKPSASSASLE------KRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYT 375
+G S S+ L+ KR++ S+ + ++R+RK AK L I++ F LCW PY
Sbjct: 373 KGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYF 432
Query: 376 LLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
+ ++ A C +C ++ + + WL + NS +NP++YPLC+ +F++ F ++L
Sbjct: 433 IFFMVIAFCK-NCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
>gi|149158706 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 109 bits (273), Expect = 4e-24
Identities = 62/221 (28%), Positives = 116/221 (52%), Gaps = 3/221 (1%)
Query: 13 SGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFF 72
S L + G ++ L +++ + + TV N LV+ A ++ L T N +
Sbjct: 6 SSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLY 65
Query: 73 LLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDR 132
+++L+++D +VGA +P+ + Y+L +W+ GR LC WL +DY+ T+S F++ ++ DR
Sbjct: 66 IVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDR 125
Query: 133 FLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSI-PEGHCYAE 191
+ SV + + Y + T RA +L W L+FL P IL W + +S+ E C +
Sbjct: 126 YRSVQQPLRYLKYRTKT-RASATILGAWFLSFLWVIP-ILGWNHFMQQTSVRREDKCETD 183
Query: 192 FFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLR 232
F+ +F + + + F+ P L + +F IY +++ + R
Sbjct: 184 FYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHR 224
Score = 78.6 bits (192), Expect = 1e-14
Identities = 36/112 (32%), Positives = 66/112 (58%), Gaps = 7/112 (6%)
Query: 322 RGSKPSASSASLE------KRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYT 375
+G S S+ L+ KR++ S+ + ++R+RK AK L I++ F LCW PY
Sbjct: 373 KGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYF 432
Query: 376 LLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427
+ ++ A C +C ++ + + WL + NS +NP++YPLC+ +F++ F ++L
Sbjct: 433 IFFMVIAFCK-NCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.137 0.442
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,414,760
Number of Sequences: 37866
Number of extensions: 920864
Number of successful extensions: 23287
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 777
Number of HSP's successfully gapped in prelim test: 559
Number of HSP's that attempted gapping in prelim test: 16155
Number of HSP's gapped (non-prelim): 5677
length of query: 445
length of database: 18,247,518
effective HSP length: 105
effective length of query: 340
effective length of database: 14,271,588
effective search space: 4852339920
effective search space used: 4852339920
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.