Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 190341068
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|190341068 forkhead-associated (FHA) phosphopeptide binding
domain 1 [Homo sapiens]
(1412 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do... 2725 0.0
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 157 9e-38
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 154 6e-37
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 144 6e-34
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 142 2e-33
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 142 2e-33
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 142 2e-33
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 142 2e-33
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 141 4e-33
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 140 7e-33
gi|71061468 centromere protein E [Homo sapiens] 139 1e-32
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 134 6e-31
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 134 8e-31
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 134 8e-31
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 134 8e-31
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 134 8e-31
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 134 8e-31
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 134 8e-31
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 134 8e-31
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 134 8e-31
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 131 5e-30
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 131 5e-30
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 131 5e-30
gi|55770834 centromere protein F [Homo sapiens] 130 9e-30
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 130 9e-30
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 130 1e-29
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 129 2e-29
gi|156104908 myosin heavy chain 6 [Homo sapiens] 129 2e-29
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 126 1e-28
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 126 2e-28
>gi|190341068 forkhead-associated (FHA) phosphopeptide binding domain
1 [Homo sapiens]
Length = 1412
Score = 2725 bits (7063), Expect = 0.0
Identities = 1412/1412 (100%), Positives = 1412/1412 (100%)
Query: 1 MKAYLKSAEGFFVLNKSTTIGRHENSDLVLQSPDIDNHHALIEYNEAECSFVLQDFNSRN 60
MKAYLKSAEGFFVLNKSTTIGRHENSDLVLQSPDIDNHHALIEYNEAECSFVLQDFNSRN
Sbjct: 1 MKAYLKSAEGFFVLNKSTTIGRHENSDLVLQSPDIDNHHALIEYNEAECSFVLQDFNSRN 60
Query: 61 GTFVNECHIQNVAVKLIPGDILRFGSAGLTYELVIENPPPVSFPWMRGPAPWPGPQPPRA 120
GTFVNECHIQNVAVKLIPGDILRFGSAGLTYELVIENPPPVSFPWMRGPAPWPGPQPPRA
Sbjct: 61 GTFVNECHIQNVAVKLIPGDILRFGSAGLTYELVIENPPPVSFPWMRGPAPWPGPQPPRA 120
Query: 121 TQQPNQAPPPSHIPFHQGVQPAPMQRSWSQAFPRPTVVLPASHRRPVSANKEMFSFVVDD 180
TQQPNQAPPPSHIPFHQGVQPAPMQRSWSQAFPRPTVVLPASHRRPVSANKEMFSFVVDD
Sbjct: 121 TQQPNQAPPPSHIPFHQGVQPAPMQRSWSQAFPRPTVVLPASHRRPVSANKEMFSFVVDD 180
Query: 181 ARKPPVIKQVWTNAMKLSEKSVAEGIPGAVPPAEIYVEEDLAQQDKDEIILLLGKEVSRL 240
ARKPPVIKQVWTNAMKLSEKSVAEGIPGAVPPAEIYVEEDLAQQDKDEIILLLGKEVSRL
Sbjct: 181 ARKPPVIKQVWTNAMKLSEKSVAEGIPGAVPPAEIYVEEDLAQQDKDEIILLLGKEVSRL 240
Query: 241 SDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQ 300
SDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQ
Sbjct: 241 SDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQ 300
Query: 301 SLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKD 360
SLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKD
Sbjct: 301 SLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKD 360
Query: 361 EQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKT 420
EQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKT
Sbjct: 361 EQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKT 420
Query: 421 QIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESV 480
QIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESV
Sbjct: 421 QIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESV 480
Query: 481 IKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWT 540
IKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWT
Sbjct: 481 IKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWT 540
Query: 541 LQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSG 600
LQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSG
Sbjct: 541 LQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSG 600
Query: 601 LQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGRE 660
LQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGRE
Sbjct: 601 LQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGRE 660
Query: 661 GEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLA 720
GEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLA
Sbjct: 661 GEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLA 720
Query: 721 QQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESE 780
QQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESE
Sbjct: 721 QQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESE 780
Query: 781 KRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQK 840
KRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQK
Sbjct: 781 KRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQK 840
Query: 841 EDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQ 900
EDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQ
Sbjct: 841 EDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQ 900
Query: 901 QKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATL 960
QKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATL
Sbjct: 901 QKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATL 960
Query: 961 KDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTE 1020
KDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTE
Sbjct: 961 KDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTE 1020
Query: 1021 AHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEE 1080
AHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEE
Sbjct: 1021 AHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEE 1080
Query: 1081 ALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKG 1140
ALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKG
Sbjct: 1081 ALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKG 1140
Query: 1141 SRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAK 1200
SRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAK
Sbjct: 1141 SRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAK 1200
Query: 1201 PDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIK 1260
PDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIK
Sbjct: 1201 PDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIK 1260
Query: 1261 NMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRR 1320
NMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRR
Sbjct: 1261 NMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRR 1320
Query: 1321 SKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKA 1380
SKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKA
Sbjct: 1321 SKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKA 1380
Query: 1381 SLKMDQEREMLRKETSSKSSQSLLHSKPSGKY 1412
SLKMDQEREMLRKETSSKSSQSLLHSKPSGKY
Sbjct: 1381 SLKMDQEREMLRKETSSKSSQSLLHSKPSGKY 1412
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 157 bits (396), Expect = 9e-38
Identities = 232/1102 (21%), Positives = 469/1102 (42%), Gaps = 117/1102 (10%)
Query: 349 VSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELR 408
V+ ++++ AKDE++ ++KE+ + ++ + ++ + + + L ++L E+L+ E
Sbjct: 847 VTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET--ELFA 904
Query: 409 EAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKL 468
EA+E +L + Q++E+ + L + + + ++ EK K++ +Q+
Sbjct: 905 EAEEMRARLAAKK-QELEEILHDLESRVEEEEERNQILQ---NEKKKMQAHIQDLEE--- 957
Query: 469 LQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVT 528
QL E +++ A +++ +++ +K ++K + + ++ E +Q+
Sbjct: 958 -QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLA 1016
Query: 529 EDN------INFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDL 582
E+ + K+ + + + K+E+T + +EK + LD ++ +L
Sbjct: 1017 EEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA--EL 1074
Query: 583 KKEVDLLQHLQVSPPVSGLQKVVL---DVLRHALSWLEEVEQLLRDLGIL-------PSS 632
+ ++D L+ LQ++ LQ + D H + L+ V +L + L +S
Sbjct: 1075 QAQIDELK-LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKAS 1133
Query: 633 PNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEE 692
NK + Q+ S A K + A + E R + E + E K E
Sbjct: 1134 RNKAEKQK-RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEA 1192
Query: 693 YITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKE--ALEEEQTRVQE 750
I R R LEE +++++ + A +K T K E L++ + +
Sbjct: 1193 QIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEH 1252
Query: 751 LEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAK 810
++L Q + L + ++ R E E + +L+N T +E + I + K A
Sbjct: 1253 KRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA- 1311
Query: 811 EAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAE 870
++E + + Q+L T+QK L + ++ + N L + EE +K + L +
Sbjct: 1312 -SLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQ 1370
Query: 871 SLALKLNE-------TLAELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIM 923
S + T+ LE K K++ E L + + D+ E ++ ++E+
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430
Query: 924 EYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTES 983
+ + Q +LE+K KK + +A K EER D A E
Sbjct: 1431 DLTVDLDHQRQVASNLEKK-------QKKFDQLLAEEKSISARYAEER--DRAEAEAREK 1481
Query: 984 SAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELN--EKQKMELE 1041
K ++ +++ L A++E Q + +LR D+ + S D+ ++ EK K LE
Sbjct: 1482 ETKALSLARALEEALEAKEEFERQNK---QLRADMEDLMSSKDDVGKNVHELEKSKRALE 1538
Query: 1042 QNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQKP 1101
Q V ++ Q +EL L +D +L+ LE ++A + + L T EQ
Sbjct: 1539 QQVEEMRTQLEELE---------DELQATEDAKLR-LEVNMQAMKAQFERDLQTRDEQNE 1588
Query: 1102 RKK----TQTCDTSVQIEPVHTE---AFSSSQEQQ-SFSDLGVRCKGSR--HEEVIQRQK 1151
KK Q + ++E + A +S ++ + DL + + + +EVI++ +
Sbjct: 1589 EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLR 1648
Query: 1152 KALSELRARIKELEKARSPDHK--DHQNESFLDLKNLRMENNVQKILLDAKPDLPTLSRI 1209
K ++++ +ELE+AR+ + ES LK+L E +L + +L + R
Sbjct: 1649 KLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAE------ILQLQEELASSERA 1702
Query: 1210 EILAPQ--NGLCNARFGSAMEKSGKMDVAEALE-----LSEKLYLDMSKTLGSLMNIKNM 1262
A Q + L + SA KS +D LE L E+L + S
Sbjct: 1703 RRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQS------------ 1750
Query: 1263 SGHVSMKYLSRQEREKVNQLRQRDLDLVFD-----KITQLKNQLGRKEELLRGYEKDVEQ 1317
+M+ L+ + R+ Q+ + +L + K + QL R+ + L+ +++E
Sbjct: 1751 ----NMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEG 1806
Query: 1318 LRRS--KVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQL----CQEKRINRAIR 1371
+S K +I ++++ +LE+ + +EA+E+A + + R E +L Q + R
Sbjct: 1807 AVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHAD 1866
Query: 1372 QQKVGTRKASLKMDQEREMLRK 1393
Q K KA+ +M Q + L +
Sbjct: 1867 QYKEQMEKANARMKQLKRQLEE 1888
Score = 141 bits (355), Expect = 5e-33
Identities = 193/963 (20%), Positives = 408/963 (42%), Gaps = 131/963 (13%)
Query: 218 EEDLAQQDKDEIIL----LLGKEVSRLSDYEIESKYKDVIIANLQNE----VAELSQKVS 269
EE L +D++ + L+ ++ S E + K +A ++N+ +++L +++
Sbjct: 985 EEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLK 1044
Query: 270 ETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEIT 329
+ +RQ ++ +K LD + Q +I L++QI L+ +K E +
Sbjct: 1045 KEEKTRQELEKAKRK---LDGETTDLQDQIAELQAQIDELKLQLAK------KEEELQGA 1095
Query: 330 SLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGS 389
+ + E L ++NA+ +V LQ I E + K + + Q +D +LEAL +
Sbjct: 1096 LARGDDETLHKNNALK--VVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKT 1153
Query: 390 RC------SVLKEEL--KQEDAHRELREAQEKELKLCKTQIQDMEK-------------- 427
+ ++EL K+E EL++A E+E K + QIQDM +
Sbjct: 1154 ELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLE 1213
Query: 428 EMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDS--RRKLLQLQ------------- 472
+ K+ +A L K+ ++ L + KV ++++ +S +RK L Q
Sbjct: 1214 QAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDR 1273
Query: 473 ---EMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTE 529
E+ + S ++ L+ LE + IK + + + + D Q E + + T
Sbjct: 1274 LRVELAEKASKLQNELDNVSTLLEEAEKKGIK--FAKDAASLESQLQDTQ--ELLQEETR 1329
Query: 530 DNINFQQKKWTLQKETQLSNSKQEETTE---NIEKLRTSLDSCQACMKISCCSHDLKKEV 586
+N + L++E +QEE E N+EK +L S A D KK+V
Sbjct: 1330 QKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLA---------DTKKKV 1380
Query: 587 DLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSA 646
D + L++ +L+ A + + +E+ + L K+++QQ +
Sbjct: 1381 D-----DDLGTIESLEEAKKKLLKDAEALSQRLEE--KALAYDKLEKTKNRLQQELDDLT 1433
Query: 647 VFTAGKAAGASGREGEAER---------------GEARARGEAQSQNQATDGREGGKALE 691
V + AS E + ++ E R R EA+++ + T +ALE
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE 1493
Query: 692 EYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQ---EKNRVKEALEEEQTRV 748
E + AKE E + K+++ L K + K++ + K +++ +EE +T++
Sbjct: 1494 EAL-----EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQL 1548
Query: 749 QELEERL-ARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKR 807
+ELE+ L A + L + + KA+ + + R Q+ E K++ E E
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDE 1608
Query: 808 KAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESL 867
+ + A+ KK +++ L + ++E + D + +L A +++ Q+
Sbjct: 1609 RKQRALAVASKKKMEID--LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA 1666
Query: 868 KAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQES-------------- 913
+ + + E+ +L++ + +++ ++E L ++ + + E++
Sbjct: 1667 SRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSA 1726
Query: 914 ---QRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEE 970
++ E I + +E++++ + L ++ +K T + E+A + A K +
Sbjct: 1727 LLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAA--ERSAAQKSD 1784
Query: 971 RPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRG 1030
+ L E AK E + K +S E + ++ E ++
Sbjct: 1785 NARQQLERQNKELKAKLQELEGAVKSKF---KATISALEAKIGQLEEQLEQEAKERAAAN 1841
Query: 1031 ELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDREL-KALEEALRASQEKH 1089
+L + + +L++ + V+ + + KE+M + ++ +++ R+L +A EEA RA+ +
Sbjct: 1842 KLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRR 1901
Query: 1090 RLQ 1092
+LQ
Sbjct: 1902 KLQ 1904
Score = 85.1 bits (209), Expect = 4e-16
Identities = 158/717 (22%), Positives = 284/717 (39%), Gaps = 101/717 (14%)
Query: 233 LGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQ------ 286
L EV L + ES++K L +V EL KVSE R E + K Q
Sbjct: 1236 LACEVKVLQQVKAESEHKR---KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNV 1292
Query: 287 -VLDEDIDAK----QKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRD 341
L E+ + K K+ SL+SQ+ Q+ + Q L+ +S I L+ E +L+
Sbjct: 1293 STLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLN-LSSRIRQLEEEKNSLQEQ 1351
Query: 342 NAITSGMVSSLQKDILAKDEQVQQLKEEVSH-------LKSQNKDKDHQLEALGSRCSVL 394
+L+K +LA Q+ K++V L+ K EAL R L
Sbjct: 1352 QEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQR---L 1408
Query: 395 KEELKQEDAHRELREAQEKELKLCKTQIQ-------DMEKEMKKLRAELRKSCTEQSVIS 447
+E+ D + + ++EL + ++EK+ KK L + E+S+ +
Sbjct: 1409 EEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE---EKSISA 1465
Query: 448 RTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRA 507
R E+ + E + +E K L L K ER QL ++ +
Sbjct: 1466 RYAEERDRAEAEARE-KETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVG 1524
Query: 508 KPFRD----KPVTDQQLIEKITQV---------TED-----NINFQQKKWTLQKETQLSN 549
K + K +QQ+ E TQ+ TED +N Q K +++ Q +
Sbjct: 1525 KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRD 1584
Query: 550 SKQEETT----ENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVV 605
+ EE + + +L L+ + ++ S K E+DL + + V
Sbjct: 1585 EQNEEKKRLLIKQVRELEAELEDERKQRALAVASKK-KMEIDLKDLEAQIEAANKARDEV 1643
Query: 606 LDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAER 665
+ LR + +++ ++ L + + ++D++ S S A + E
Sbjct: 1644 IKQLRKLQAQMKDYQRELEE-----ARASRDEIFAQSKESEKKLKSLEAEILQLQEELAS 1698
Query: 666 GEARARGEAQSQNQATDGREGGKALEEYITQERNRAK-------ETLEEERKRMQELESL 718
E R Q +++ D + + + E+ R + E LEEE+ M+ L
Sbjct: 1699 SERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDR 1758
Query: 719 LAQQ---------KKALAKSITQEKNRVKEALEEE----QTRVQELEERLARQKEVLESS 765
+ + A +S Q+ + ++ LE + + ++QELE + + + S+
Sbjct: 1759 FRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISA 1818
Query: 766 IAHEKRKAKEALESEKRKVQDLENHLTQ--QKEISE--SNIAYEKRKA---KEAMEKEKK 818
+ + + +E LE E ++ + N L + +K++ E + E+R A KE MEK
Sbjct: 1819 LEAKIGQLEEQLEQEAKE-RAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANA 1877
Query: 819 KVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALK 875
+++ L+ +L + +EE L +L DA T+A E L E LK
Sbjct: 1878 RMKQLKRQLEEAEEEATRANASRRKLQRELDDA---------TEANEGLSREVSTLK 1925
Score = 84.3 bits (207), Expect = 7e-16
Identities = 146/803 (18%), Positives = 339/803 (42%), Gaps = 107/803 (13%)
Query: 193 NAMKLSEKSVAEGIPGAVPPAEIYVEEDLAQQDKDEIILLLGKEVSRLSD-YEIESKYKD 251
N + ++ ++E + E ++ AQQ E+ +EV+ L E E+K +
Sbjct: 1135 NKAEKQKRDLSEELEALKTELEDTLDTTAAQQ---ELRTKREQEVAELKKALEEETKNHE 1191
Query: 252 VIIANLQNEVA----ELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQIS 307
I +++ A ELS+++ + + N ++ Q + ++++ + K +Q +K++
Sbjct: 1192 AQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESE 1251
Query: 308 ALQKGYS---KVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQ 364
+K + L +SE + L + L+ + S ++ +K + +
Sbjct: 1252 HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA 1311
Query: 365 QLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEEL----KQEDAHRELREAQEKELKLCKT 420
L+ ++ + +++ Q L SR L+EE +Q++ E R+ EK++ ++
Sbjct: 1312 SLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQS 1371
Query: 421 QIQDMEKEM-------KKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQE 473
Q+ D +K++ + L +K + +S+ L EK+ +KL++ R +L +
Sbjct: 1372 QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDD 1431
Query: 474 MG---NRESVIKINLERAVGQLEHFRSQV--IKATYGRAKP-----FRDKPVTDQQLIEK 523
+ + + + NLE+ + + ++ I A Y + R+K L
Sbjct: 1432 LTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARA 1491
Query: 524 ITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENI--------------EKLRTSLDSC 569
+ + E F+++ L+ + + S +++ +N+ E++RT L+
Sbjct: 1492 LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551
Query: 570 Q--------ACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQ 621
+ A +++ +K + + + LQ + +K +L ++ E+E
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFE--RDLQTRDEQNEEKKRLL--IKQVRELEAELED 1607
Query: 622 LLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAG----------ASGREGEAERGEARA- 670
+ + +S K ++ + + A KA A ++ + E EARA
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARAS 1667
Query: 671 RGEAQSQNQATDGREGGKALEEYITQ------ERNRAKETLEEERKRMQELESLLAQQKK 724
R E +Q++ ++ + K+LE I Q RA+ E+ER + + + A K
Sbjct: 1668 RDEIFAQSKESEKKL--KSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKS 1725
Query: 725 ALAKSITQEKNRV---KEALEEEQTRVQELEERLAR---QKEVLESSIAHEKR------K 772
AL + + R+ +E LEEEQ+ ++ L +R + Q + L + +A E+
Sbjct: 1726 ALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDN 1785
Query: 773 AKEALESE----KRKVQDLENHLTQQKEISESNI--------------AYEKRKAKEAME 814
A++ LE + K K+Q+LE + + + + S + A E+ A + +
Sbjct: 1786 ARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVR 1845
Query: 815 KEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLAL 874
+ +KK++++ ++ ++ + +++ + N ++ +EE ++ + L
Sbjct: 1846 RTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQR 1905
Query: 875 KLNETLAELETTKTKMIMVEERL 897
+L++ E ++ ++ RL
Sbjct: 1906 ELDDATEANEGLSREVSTLKNRL 1928
Score = 73.2 bits (178), Expect = 2e-12
Identities = 132/636 (20%), Positives = 261/636 (41%), Gaps = 90/636 (14%)
Query: 809 AKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMV--EETQKTKATES 866
A++A K+++++ L+ L+L+ + + K+ L + EE + K E
Sbjct: 802 ARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEEL 861
Query: 867 LKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKA-LQDEQESQRHGFEEEIMEY 925
LK + K+ L E+E K + ++ E+ ++ +Q + L E E R + E
Sbjct: 862 LKVKEKQTKVEGELEEMER-KHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQEL 920
Query: 926 KEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSA 985
+E + + EE+ Q + KK++ I L++ + R + L E+
Sbjct: 921 EEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKI 980
Query: 986 KDMAYEHLI----------------DDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLR 1029
K M E L+ D + ++ ++E L K + +SDL
Sbjct: 981 KKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLE 1040
Query: 1030 GELNEKQK----------------MELEQNVVLVQQQSKELSV-LKEKMAQMSSLVEKKD 1072
L +++K +L+ + +Q Q EL + L +K ++ + + D
Sbjct: 1041 ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGD 1100
Query: 1073 -------------RELKA----------LEEALRASQEKHRLQLNTEKEQKPRKKTQTCD 1109
REL+A E+A R EK + L+ E E + T D
Sbjct: 1101 DETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLD 1160
Query: 1110 TSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARS 1169
T+ + + T+ E + + + ++ +++ QR AL EL ++++ ++ ++
Sbjct: 1161 TTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKA 1220
Query: 1170 PDHKDHQNESFLDLKNLRMENNV-QKILLDAKPDLPTL-SRIEILAPQNGLCNARFGSAM 1227
K+ Q D K L E V Q++ +++ L ++++ L + +
Sbjct: 1221 NLEKNKQGLE-TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELA 1279
Query: 1228 EKSGKM-----DVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVN-Q 1281
EK+ K+ +V+ LE +EK + +K SL + + L + R+K+N
Sbjct: 1280 EKASKLQNELDNVSTLLEEAEKKGIKFAKDAASL----ESQLQDTQELLQEETRQKLNLS 1335
Query: 1282 LRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLR------RSKV--------SIEM 1327
R R L+ ++ L+ Q +EE + EK V L+ + KV S+E
Sbjct: 1336 SRIRQLE---EEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392
Query: 1328 YQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQE 1363
+ ++ K + + + EEKAL + LE+ +++L QE
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQE 1428
Score = 46.2 bits (108), Expect = 2e-04
Identities = 54/270 (20%), Positives = 112/270 (41%), Gaps = 24/270 (8%)
Query: 222 AQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAE-------LSQKVSETTTS 274
A+Q++DE+ + S S E + + IA L+ E+ E L+ + +TT
Sbjct: 1706 AEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ 1765
Query: 275 RQN-------EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSE 327
E+ +QK + ++ + KE LK+++ L+ T+S ++
Sbjct: 1766 VDTLNAELAAERSAAQKSDNARQQLERQNKE---LKAKLQELEGAVKSKFKATISALEAK 1822
Query: 328 ITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEAL 387
I L+ + E ++ A + +V +K + QV+ + K Q + + +++ L
Sbjct: 1823 IGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQL 1882
Query: 388 GSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVIS 447
+ +EE + +A R ++EL + + +E+ L+ LR+ S
Sbjct: 1883 KRQLEEAEEEATRANAS---RRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSS 1939
Query: 448 RTLREKSKVE----EKLQEDSRRKLLQLQE 473
R+ R + +E E +D+ K + E
Sbjct: 1940 RSGRRQLHLEGASLELSDDDTESKTSDVNE 1969
Score = 31.2 bits (69), Expect = 7.4
Identities = 28/125 (22%), Positives = 65/125 (52%), Gaps = 15/125 (12%)
Query: 1274 QEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVA 1333
+E+ + + Q + +L F + +++ +L K++ L D+E S+V E ++Q+
Sbjct: 887 EEKNILAEQLQAETEL-FAEAEEMRARLAAKKQELEEILHDLE----SRVEEEEERNQIL 941
Query: 1334 KLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRK 1393
+ EK ++ ++ +E QL +E+ + ++ +KV T +A +K +E +L +
Sbjct: 942 Q---------NEKKKMQAHIQDLEEQLDEEEGARQKLQLEKV-TAEAKIKKMEEEILLLE 991
Query: 1394 ETSSK 1398
+ +SK
Sbjct: 992 DQNSK 996
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 154 bits (389), Expect = 6e-37
Identities = 262/1275 (20%), Positives = 543/1275 (42%), Gaps = 223/1275 (17%)
Query: 202 VAEGIPGAVPPAEIYVEEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEV 261
V + +P P AE++ +E+ + D + ++ G V L + K ++ NL
Sbjct: 244 VLKPLPQLEPQAEVFTKEENPESDGEPVVED-GTSVKTLETLQQRVKRQE----NLLKRC 298
Query: 262 AELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTL 321
E Q E T +EKE L E +D + +E++ +K +
Sbjct: 299 KETIQSHKEQCTLLTSEKE------ALQEQLDERLQELEKIKDL--------------HM 338
Query: 322 SERNSEITSL---KNEGENLKRDNAITSGMVSSLQKDILA-KDEQVQQLKEEVSHLKSQN 377
+E+ IT L KN E L++D + + L K+E++ QL+ + + +Q
Sbjct: 339 AEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQG 398
Query: 378 KDKDHQLE-----ALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQD----MEKE 428
++ Q E A L K E+A R+L+ ++++K + ++ +++E
Sbjct: 399 EELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQE 458
Query: 429 MKKLRAE----LRKSCTEQSVISRTLREK--SKVEEKLQEDSRRKLLQLQEM------GN 476
+ +++ E ++KS EQ + L EK ++ E++L + + + + QE +
Sbjct: 459 LSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKS 518
Query: 477 RESVIKINLER------AVGQLEHFRSQVIKATYGRAKPFRDKPVTDQ----QLIEKITQ 526
+ +KI+ E+ A+ +LE + ++ + + + + + T + +L + +
Sbjct: 519 QSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEK 578
Query: 527 VTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEV 586
++N N Q K + E + N +E T +EK +T L+S LK +
Sbjct: 579 SLQENKN-QSKDLAVHLEAE-KNKHNKEITVMVEKHKTELES-------------LKHQQ 623
Query: 587 DLL--QHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGN 644
D L + LQV + + ++ LR +E E LL+D I+ + +++ + +
Sbjct: 624 DALWTEKLQV---LKQQYQTEMEKLREKCE--QEKETLLKDKEII-FQAHIEEMNEKTLE 677
Query: 645 SAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKET 704
+ S E + + E TD + + LE + +++N ++
Sbjct: 678 KLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK--QELEAKMDEQKNHHQQQ 735
Query: 705 LEEERKRMQELESLLAQQKKALAKSITQEKNRVKEA---LEEEQTRVQELEERLARQKEV 761
++ ++E E + + +KAL I Q + +KE L+E Q V+ LE + R +
Sbjct: 736 VD---SIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGE 792
Query: 762 LE------------SSIAHEKRKA-KEALESEKRKVQDLE-NHLTQQKEISESNIAYEKR 807
L+ S HE+ KA +E L ++K+ DLE + K+++E + +K+
Sbjct: 793 LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAE--VEAQKK 850
Query: 808 KAKEAMEKEKKKVQDLENRLTKQKEELELK-EQKEDVLNNKLSDALAMVEETQKTKATES 866
++ K +VQDL +L KQ E+E K + V +KL D E+T+
Sbjct: 851 DVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTK------- 903
Query: 867 LKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYK 926
+ L K N L E K ++ ++ ++L ++ + L +E E++ E+++ + K
Sbjct: 904 ---QILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVK 960
Query: 927 EQIKQHAQT----IVSLEEKLQK--------VTQHHKKIEGEIATLKD------NDPAPK 968
++ K+ +T ++ E KL+K ++Q K+ ++ + +D +
Sbjct: 961 QKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSR 1020
Query: 969 EERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDL 1028
E Q + +TE ++ ++D+++ ++ L+QQ ++L E H ++
Sbjct: 1021 LETNQKEQIESLTEVHRRE------LNDVISIWEKKLNQQ------AEELQEIH----EI 1064
Query: 1029 RGELNEKQKMELEQNVVLV----QQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRA 1084
+ + E++ EL+Q ++L ++ +KE++ LKE+ + + + + +LK + +
Sbjct: 1065 QLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNS 1124
Query: 1085 -SQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRH 1143
+Q++ +L+ + EK + K+ +T +Q + V + +
Sbjct: 1125 LAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLA-------------------- 1164
Query: 1144 EEVIQRQKKALSELRARIKELEKARSPDHKDHQN--ESFLDLKNLRMENNVQ-------- 1193
EE ++ + S+L+ +E + +S K +++ + L+ K L E +Q
Sbjct: 1165 EEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKT 1224
Query: 1194 KILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTL 1253
+ LL+AK T I I + + +R ++ K V EAL + ++ L
Sbjct: 1225 EALLEAK----TNELINISSSKTNAILSRISHCQHRTTK--VKEALLIKTCTVSELEAQL 1278
Query: 1254 GSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLD---LVFDK----------------- 1293
L +N + ++S + + Q EK NQ++ D LV +K
Sbjct: 1279 RQLTEEQN-TLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK 1337
Query: 1294 ---ITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKE---AEEKA 1347
ITQLK +L E + E+L+ KV I Q+ L + +E++A
Sbjct: 1338 ESCITQLKKEL---SENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEA 1394
Query: 1348 LLKEALERMEHQLCQ 1362
+ ++ + + C+
Sbjct: 1395 AISSLRKQYDEEKCE 1409
Score = 121 bits (303), Expect = 5e-27
Identities = 267/1319 (20%), Positives = 539/1319 (40%), Gaps = 203/1319 (15%)
Query: 187 IKQVWTNAMKL------SEKSVAEGIPGAVPPAEIYVE-EDLAQQDKDEIILLLGKEVSR 239
IKQ+ T +L SE++ E + A+ A+ E + + DE I K + +
Sbjct: 391 IKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQI----KTIEK 446
Query: 240 LSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQ---NEKEISQKCQVLDEDIDAKQ 296
S+ E S ++ ++ ++ EV ++ +K SE ++ +EKE+++K Q L + + ++
Sbjct: 447 TSEEERISLQQE--LSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRE 504
Query: 297 KEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSG--MVSSLQK 354
+E Q + AL+K S+ L +S+ + SL E L++ +T + LQ+
Sbjct: 505 REFQ--EQMKVALEKSQSEYL--KISQEKEQQESLALEELELQKKAILTESENKLRDLQQ 560
Query: 355 DILAKDEQVQQLKE--EVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHR-ELREAQ 411
+ ++ +L+ E S +++N+ KD + + KE + H+ EL +
Sbjct: 561 EAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLK 620
Query: 412 EKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQL 471
++ L ++Q ++++ + +LR+ C ++ L++K + + E+ K L+
Sbjct: 621 HQQDALWTEKLQVLKQQYQTEMEKLREKCEQEK--ETLLKDKEIIFQAHIEEMNEKTLEK 678
Query: 472 QEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRD-KPVTDQQLIEKITQVTED 530
++ E LE +L S+V+KA + + K TD+ E ++ E
Sbjct: 679 LDVKQTE------LESLSSEL----SEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQ 728
Query: 531 NINFQQKKWTLQKETQLSNSKQEETTEN-IEKLRTSLDSCQACMK-----ISCCSHDLKK 584
+ QQ+ ++ KE ++S + E+ ++ I +L L +K + D+K+
Sbjct: 729 KNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKR 788
Query: 585 EVDLLQHLQVSPPV-SGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSG 643
LQ V Q + + L +++Q L DL
Sbjct: 789 SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDL----------------- 831
Query: 644 NSAVFTAGKAAGASGREGEAER---GEARARGEAQSQNQATDGREGGKALEEYITQERNR 700
E ER + A EAQ ++ T+ L+ + Q ++
Sbjct: 832 ------------------ETERILLTKQVAEVEAQKKDVCTE-------LDAHKIQVQDL 866
Query: 701 AKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKE 760
++ LE++ M++ L Q ++ + +E+ + K+ L E++ + ++ E ++ E
Sbjct: 867 MQQ-LEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIE 925
Query: 761 VLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKV 820
+L + L +++ + L + + E + K+KAKE E KKK+
Sbjct: 926 IL-----------TQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKL 974
Query: 821 QDLENRLTKQKEELELK-EQKEDVLNNK-----------LSDALAMVEETQKTKATESLK 868
D E +L K+ E L+ QKE N K +SDA++ +E QK + +
Sbjct: 975 LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 1034
Query: 869 AESLAL---------KLNETLAELETTKTKMIMVEERLILQQKMVKAL----QDEQESQR 915
L KLN+ EL+ + +E+ + + K L ++E +
Sbjct: 1035 VHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI 1094
Query: 916 HGFEEE-------IMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEI-ATLKDNDPAP 967
+EE + E +EQ+KQ + + SL + K+ H +K+E ++ +LK+N
Sbjct: 1095 TWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFL- 1153
Query: 968 KEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSD 1027
Q+ LV + L L +E S + K K L +
Sbjct: 1154 -----QEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKK 1208
Query: 1028 LRGELNEKQKMELEQNVVLVQQQSKEL-SVLKEKMAQMSSLVEKKDRELKALEEAL---- 1082
L EL + + ++ L++ ++ EL ++ K + S + ++EAL
Sbjct: 1209 LSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKT 1268
Query: 1083 -----------RASQEKHRLQLNTEK--EQKPRKKTQTCDTSVQIEPVHTEAFSSSQE-- 1127
+ ++E++ L ++ ++ Q K+ Q IE + TE + +E
Sbjct: 1269 CTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGG 1328
Query: 1128 --QQSFSD-----LGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESF 1180
QQ+ S+ ++ + S + + K+ L E + I L K + + QN
Sbjct: 1329 NQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSIS 1388
Query: 1181 LD-----LKNLRMENNVQKI-LLDAKPDL----PTLSRIEILAPQNGLCNARFGSAMEKS 1230
L + +LR + + +K LLD DL TLS+ +I SA+E+
Sbjct: 1389 LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKI-------------SALEQV 1435
Query: 1231 GKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLV 1290
+ + SE S+ +K + + +K E+++ L + +LD
Sbjct: 1436 DDW----SNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491
Query: 1291 FDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLK 1350
+ LK ++ + + E ++E +S+ +++ +LED I ++ E L
Sbjct: 1492 NKRFDCLKGEMEDDKSKMEKKESNLETELKSQT------ARIMELEDHITQKTIEIESLN 1545
Query: 1351 EALERMEHQ--LCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSLLHSK 1407
E L+ Q + ++ + + Q++G K + + E ++L E S ++ L +K
Sbjct: 1546 EVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETK 1604
Score = 120 bits (300), Expect = 1e-26
Identities = 247/1172 (21%), Positives = 477/1172 (40%), Gaps = 186/1172 (15%)
Query: 278 EKEISQKCQVLDE----DIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKN 333
EK+++Q+ + L E + K++E+ LK +I L G K E N EIT LK
Sbjct: 1048 EKKLNQQAEELQEIHEIQLQEKEQEVAELKQKI--LLFGCEK------EEMNKEITWLKE 1099
Query: 334 EGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSV 393
EG +K+D + + LQ+ + K V L ++ + LK+ + + L +
Sbjct: 1100 EG--VKQDTTL-----NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTF 1152
Query: 394 LKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREK 453
L+E+L + + L E ++++ ++++ ++E + L++ KS +++L +K
Sbjct: 1153 LQEQLVEL---KMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKS-------NKSLEDK 1202
Query: 454 SKVEEKLQEDSR-------RKLLQLQEMGNRESVIKINLERA---VGQLEHFRSQVIKAT 503
S +KL E+ +K L E E +I I+ + + ++ H + + K
Sbjct: 1203 SLEFKKLSEELAIQLDICCKKTEALLEAKTNE-LINISSSKTNAILSRISHCQHRTTKVK 1261
Query: 504 YGRAKPFRDKPVTDQQLIEKITQVTED----NINFQQKKWTLQ-KETQLSNSK---QEET 555
+ K T +L ++ Q+TE+ NI+FQQ L+ KE Q+ + K +
Sbjct: 1262 ----EALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLV 1317
Query: 556 TENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVL--DVLRHAL 613
TE + + QA + C LKKE+ + V L + L+
Sbjct: 1318 TEKEALQKEGGNQQQAASEKESCITQLKKELS-----------ENINAVTLMKEELKEKK 1366
Query: 614 SWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREG-EAERGEARARG 672
+ + + L DL + Q+Q NS + +AA +S R+ + E+ E +
Sbjct: 1367 VEISSLSKQLTDLNV--------QLQ----NSISLSEKEAAISSLRKQYDEEKCELLDQV 1414
Query: 673 EAQSQNQATDGREGGKALEEY------ITQERNRAKETLEEERKRMQELE-SLLAQQKKA 725
+ S T +E ALE+ ++ + +A+ + + ++EL+ L + K+A
Sbjct: 1415 QDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEA 1474
Query: 726 LAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQ 785
K ++ N +KE L+++ R L+ + K +E ++ + L+S+ ++
Sbjct: 1475 YEKD--EQINLLKEELDQQNKRFDCLKGEMEDDKSKMEK----KESNLETELKSQTARIM 1528
Query: 786 DLENHLTQQK-EISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVL 844
+LE+H+TQ+ EI N E L+ Q++D+
Sbjct: 1529 ELEDHITQKTIEIESLN------------------------------EVLKNYNQQKDIE 1558
Query: 845 NNKLSDALAMVEETQKTKATESLKAESLALKLNETL----AELETTKTKMIMVEERLILQ 900
+ +L L +E + K +AE L L + AELET K ++ V + +
Sbjct: 1559 HKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSK 1618
Query: 901 QKMVKALQDEQESQRHGFEEEIMEYKEQ-----IKQHAQTIVSLEEKLQKVTQHH----- 950
++ +KAL+D ES+ E+ EQ KQ + EE+ +K T+ H
Sbjct: 1619 EEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELN 1678
Query: 951 ---KKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQ 1007
++ E E+ L++ + E + L+ P + + + D QK +
Sbjct: 1679 TKLQEREREVHILEEKLKS-VESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQK---TY 1734
Query: 1008 QEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSL 1067
+E I L+++LTE + + E E E Q++ +L + K + S+
Sbjct: 1735 EEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMR-CQYQERLIKLEHAEAKQHEDQSM 1793
Query: 1068 VEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQE 1127
+ L+E L +K+ L + E++ K +E V + + QE
Sbjct: 1794 IGH-------LQEELEEKNKKYSLIVAQHVEKEGGK--NNIQAKQNLENVFDDVQKTLQE 1844
Query: 1128 QQSFSDLGVRCKGSRHEEVIQRQKKA----LSELRARIKELEKARSPDHKDHQNESFLDL 1183
++ + + K + + RQK+ + EL ++ ++L+ + D ++ E
Sbjct: 1845 KELTCQI-LEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTE----- 1898
Query: 1184 KNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSE 1243
L EN +K +K L + + Q+ + A + K+
Sbjct: 1899 --LLEENTEEK----SKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLG--------- 1943
Query: 1244 KLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDK-----ITQLK 1298
K + + K L L + K ++ EK+ Q Q DL+L + + +
Sbjct: 1944 KEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQ-EQEDLELKHNSTLKQLMREFN 2002
Query: 1299 NQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEH 1358
QL +KE+ L K+ + +V E+ +S + + K AE+ LK +R E
Sbjct: 2003 TQLAQKEQELEMTIKETIN-KAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEE 2061
Query: 1359 QL-CQEKRINRAIRQQKVGTRKASLKMDQERE 1389
L +E+ + +R + + K Q+ E
Sbjct: 2062 ILDAREEEMTAKVRDLQTQLEELQKKYQQKLE 2093
Score = 108 bits (269), Expect = 5e-23
Identities = 238/1214 (19%), Positives = 499/1214 (41%), Gaps = 196/1214 (16%)
Query: 361 EQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKT 420
E+ QQL++ ++ +Q + SR S E+L + +RE + Q KL +
Sbjct: 11 EEQQQLQQALA--PAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKL-QL 67
Query: 421 QIQDMEKEMKK-LRAELRKSCTEQSVISRTLREK----------SKVEEKLQEDSRRK-L 468
++ +E + ++ L +S +++S++ + RE + + DS + L
Sbjct: 68 RVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDL 127
Query: 469 LQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPV-------TDQQLI 521
+ + N+E +I+ L R L +R + + R+K + + +
Sbjct: 128 VGNSDSLNKEQLIQ-RLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSL 186
Query: 522 EKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHD 581
+I ++ E+ QQ K LQ+E S EE + I L+T + + ++ + D
Sbjct: 187 RRIAELREELQMDQQAKKHLQEEFDAS---LEEKDQYISVLQTQVSLLKQRLRNGPMNVD 243
Query: 582 LKKEVDLLQ-----HLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLL-RDLGILPSSPNK 635
+ K + L+ + P S + VV D ++ LE ++Q + R +L K
Sbjct: 244 VLKPLPQLEPQAEVFTKEENPESDGEPVVEDGT--SVKTLETLQQRVKRQENLLKRC--K 299
Query: 636 DQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYIT 695
+ +Q + T+ K A + + E + + K L E +
Sbjct: 300 ETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLE 359
Query: 696 QERNRA-KETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEER 754
Q++ ET + + ++ E +AQ + + + TQ + ++ + E+ +ELE+
Sbjct: 360 QDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKA 419
Query: 755 LARQKEVLESSIAHEKRKAKEALESEKRKVQDL--ENHLTQQKEIS---ESNIAYEKRKA 809
L+ ++ E+ +RK K ++ + + ++ E ++ Q+E+S + + K+ +
Sbjct: 420 LSTAQKTEEA-----RRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSS 474
Query: 810 KEAMEK----EKKKVQDLENRLTK--QKEELELKEQKEDVLNNKLSDAL--AMVEETQKT 861
+E + K +K++ E LTK Q E E +EQ + L S+ L + +E Q++
Sbjct: 475 EEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQES 534
Query: 862 KATESLKAESLAL------KLNETLAELETTKTKMIMVEERL--ILQQK----------- 902
A E L+ + A+ KL + E ET +T+++ +E L LQ+
Sbjct: 535 LALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHL 594
Query: 903 -------------MVKALQDEQESQRH---------------GFEEEIMEYKEQIKQHAQ 934
MV+ + E ES +H ++ E+ + +E+ +Q +
Sbjct: 595 EAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKE 654
Query: 935 TIV------------------------------SLEEKLQKVTQHHKKIEGEIATLKDND 964
T++ SL +L +V + K+E E++ LKD
Sbjct: 655 TLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQT 714
Query: 965 PAPKEERPQDPLVAPMTESSAKDM--------AYEHLIDDLLAAQKEILSQQEVIMKLR- 1015
K+E L A M E +E I A K+ ++Q E+++K R
Sbjct: 715 DKMKQE-----LEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERD 769
Query: 1016 KDLTEAHSRMSDLRGELNEKQ--------KMELEQNV-VLVQQQSK----ELSVLKEKMA 1062
K L E + + +L ++ + K+++ Q+ +Q+K +L+ L++K+
Sbjct: 770 KHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829
Query: 1063 QMSS---LVEKKDRELKALEEALRASQEKHRLQL----------NTEKEQKPRKKTQTCD 1109
+ + L+ K+ E++A ++ + + H++Q+ N+E EQK + TQ +
Sbjct: 830 DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYE 889
Query: 1110 TSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARS 1169
+ ++ E ++ L +R +G + E I QK + E I E
Sbjct: 890 SKLEDGNKEQEQTKQILVEKENMILQMR-EGQKKEIEILTQKLSAKEDSIHILNEEYETK 948
Query: 1170 PDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEK 1229
+++ + E + K M+ ++K LLD + L +E A + +F + M +
Sbjct: 949 FKNQEKKMEK-VKQKAKEMQETLKKKLLDQEAKLK--KELENTALELSQKEKQFNAKMLE 1005
Query: 1230 SGKMDVAEALELSEKLYLDMSKTLGSLMNI--KNMSGHVSM-KYLSRQEREKVNQLRQRD 1286
+ + A + +L + + + SL + + ++ +S+ + Q+ E++ ++ +
Sbjct: 1006 MAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQ 1065
Query: 1287 LDLVFDKITQLKNQL----GRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKE 1342
L ++ +LK ++ KEE+ + E+ + ++ Q Q+ + +
Sbjct: 1066 LQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSL 1125
Query: 1343 AEEKALLKEALERMEHQLCQEKRINRAIRQQ-------------KVGTRKASLKMDQERE 1389
A+++ LK LE++E L + + N +++Q KV + LK E
Sbjct: 1126 AQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEF 1185
Query: 1390 MLRKETSSKSSQSL 1403
K + KS++SL
Sbjct: 1186 QSLKSSHEKSNKSL 1199
Score = 68.2 bits (165), Expect = 5e-11
Identities = 150/777 (19%), Positives = 313/777 (40%), Gaps = 164/777 (21%)
Query: 175 SFVVDDARKPPV--IKQV--WTNAMKLSEKSVAEGIP---GAVPPAEIYVE-EDLAQQDK 226
SF VD K + ++QV W+N +K V +I +E + +K
Sbjct: 1418 SFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEK 1477
Query: 227 DEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQ 286
DE I LL +E+ + ++K D + ++++ +++ +K S T +++ + +
Sbjct: 1478 DEQINLLKEELDQ------QNKRFDCLKGEMEDDKSKMEKKESNLETELKSQ---TARIM 1528
Query: 287 VLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITS 346
L++ I K EI+SL + K Y++ E ++ + GE ++DN +
Sbjct: 1529 ELEDHITQKTIEIESLNEVL----KNYNQQKDIEHKELVQKLQHFQELGE--EKDNRVKE 1582
Query: 347 G--MVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRC------------- 391
+ +L+ + + +++ K+E+ H+ K K+ +L+AL R
Sbjct: 1583 AEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKR 1642
Query: 392 ------SVLKEEL--KQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQ 443
+ +K++L + E+ + ++ E L T++Q+ E+E+ L +L+ + Q
Sbjct: 1643 KAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQ 1702
Query: 444 S---VISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLE------RAVGQLEH 494
S ++ R+ + + E+ + DS+ + + E + SV++ NL + VGQ +
Sbjct: 1703 SETLIVPRSAKNVAAYTEQEEADSQGCVQKTYE--EKISVLQRNLTEKEKLLQRVGQEKE 1760
Query: 495 ------------FRSQVIKATYGRAKPFRDKPVT---DQQLIEK-------ITQVTE--- 529
++ ++IK + AK D+ + ++L EK + Q E
Sbjct: 1761 ETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEG 1820
Query: 530 --DNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVD 587
+NI +Q + + Q + ++E T + +E+ LDSC +KEV
Sbjct: 1821 GKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLV----------RQKEVH 1870
Query: 588 LLQHLQVSPPVSGLQKVV-LDVLRHALSWLEE-VEQLLRDLGILPSSPNKDQVQQFSGNS 645
++ +++ LQ + +D LEE E+ + + P + + Q
Sbjct: 1871 RVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEF 1930
Query: 646 AVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETL 705
+ A + G+E + + R + Q +E + EE I QE+ +
Sbjct: 1931 KLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKH 1990
Query: 706 EEERKR-MQELESLLAQQKKALAKSITQEKNRVKE------------------------- 739
K+ M+E + LAQ+++ L +I + N+ +E
Sbjct: 1991 NSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDD 2050
Query: 740 --------------ALEEE--------QTRVQELEERLARQKEVLESSIAHEKRKAKEAL 777
A EEE QT+++EL+ +K ++ L
Sbjct: 2051 DLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQ------------------KKYQQKL 2092
Query: 778 ESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEEL 834
E E+ D + Q ++++ K KE ++ ++++ +LE+RL K ++ +
Sbjct: 2093 EQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE--QEFREQIHNLEDRLKKYEKNV 2147
Score = 37.7 bits (86), Expect = 0.079
Identities = 29/167 (17%), Positives = 80/167 (47%), Gaps = 28/167 (16%)
Query: 224 QDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQ 283
Q + E+ + + + +++ + E E ++ + Q E +L +K++E + ++ +
Sbjct: 2007 QKEQELEMTIKETINKAQEVEAE------LLESHQEETNQLLKKIAE------KDDDLKR 2054
Query: 284 KCQVLDEDIDAKQKE----IQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLK 339
+ +E +DA+++E ++ L++Q+ LQK Y + L Q + N +T ++ + + +
Sbjct: 2055 TAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQ 2114
Query: 340 RDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEA 386
+ I+ + Q+ +E++ +L+ + K + + A
Sbjct: 2115 KTTLISDSKLKE------------QEFREQIHNLEDRLKKYEKNVYA 2149
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 144 bits (363), Expect = 6e-34
Identities = 260/1212 (21%), Positives = 502/1212 (41%), Gaps = 159/1212 (13%)
Query: 253 IIANLQNEVAELSQKVSETTTSRQN-EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQK 311
I+ Q ++ L +++++ ++R E E+++ ++L E K +I ++ +I L
Sbjct: 208 ILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTE----KDAQIAMMQQRIDRLAL 263
Query: 312 GYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVS 371
K L + E+ L+++ E+L T L+ + D ++ QL EE
Sbjct: 264 LNEKQAASPLEPK--ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEE-- 319
Query: 372 HLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKK 431
N D +L S L +DA EL E K + + +EKE+
Sbjct: 320 -----NGDLSFKLREFASHLQQL------QDALNELTEEHSKATQEWLEKQAQLEKELSA 368
Query: 432 LRAELRKSCTEQS--VISRTLREKSKVEEKLQEDSRRK-------LLQLQEMGNRESVIK 482
+ K C E+ ++ L + + +LQ++ ++ +LQL+ + + +
Sbjct: 369 ALQD--KKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLA 426
Query: 483 IN---LERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKW 539
N L+ V LE R Q F ++ QQL IT + N Q K
Sbjct: 427 ANNTQLQARVEMLETERGQQEAKLLAERGHFEEEK---QQLSSLITDLQSSISNLSQAKE 483
Query: 540 TLQKETQLSNSKQEETTENIEKLRTSLDSC--QACMKISCCSHDLK-KEVDLLQHLQVSP 596
L++ +Q ++ ++ T+L++ Q +++ K K+ L Q LQ
Sbjct: 484 ELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQE 543
Query: 597 PVS-GLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAG 655
S GL+ V S L++ EQ L+++ + +D QQ + TA +
Sbjct: 544 QASQGLRHQV----EQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLA------TAAEERE 593
Query: 656 ASGREGEAERGEARA------------RGEAQSQNQATDGREGGKALEEYITQERNRAKE 703
AS RE +A + A + + Q N+A D + + E +R E
Sbjct: 594 ASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVE 653
Query: 704 TL----EEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQK 759
L E R+ E ++ +A+ + L Q+K KE + +E+ ++QE + L
Sbjct: 654 ELQACVETARQEQHEAQAQVAELELQLRSE--QQKATEKERVAQEKDQLQEQLQALKESL 711
Query: 760 EVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKK 819
+V + S+ EKR+A +ALE ++R + +L K + S + KR+ KE +E+E+
Sbjct: 712 KVTKGSLEEEKRRAADALEEQQRCISEL-------KAETRSLVEQHKRERKE-LEEERAG 763
Query: 820 VQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNET 879
+ LE RL ++ E + + +VL +L++A+A + T +++ E L E A +
Sbjct: 764 RKGLEARL---QQLGEAHQAETEVLRRELAEAMA-AQHTAESEC-EQLVKEVAAWRERYE 818
Query: 880 LAELETTKTKMIMVEERLILQQKMVKALQDEQESQRH--GFEEEI-MEYKEQIKQHAQTI 936
++ E + + E+ + L+++ KA Q+ QE++ G E ++ Q + A+
Sbjct: 819 DSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELH 878
Query: 937 VSLEEKLQKVTQHH---KKIEGEIATLKDNDPA-PKEERPQDPLVAPMTESSAKDMAYEH 992
+L LQ+V + +K+ +++TL++ A KE + LV E ++ A
Sbjct: 879 ANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQ--QETASRE 936
Query: 993 LIDDLLAA------------QKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMEL 1040
L+ + A ++ S Q + + ++ + + + LR L E Q +
Sbjct: 937 LVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQ 996
Query: 1041 EQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQK 1100
E+ QQ +E++ L ++ + + + ALE+A RA E RLQ N EQ+
Sbjct: 997 EER----GQQEREVARLTQERGRAQADL--------ALEKAARAELEM-RLQ-NALNEQR 1042
Query: 1101 PRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRAR 1160
T +Q H ++Q+ G+ Q K L ELR
Sbjct: 1043 VEFAT------LQEALAHALTEKEGKDQELAKLRGLEA----------AQIKELEELRQT 1086
Query: 1161 IKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCN 1220
+K+L++ + K+H + S + A PT ++E L +
Sbjct: 1087 VKQLKEQLAKKEKEHASGSGAQSE-------------AAGRTEPTGPKLEALRAEVSKLE 1133
Query: 1221 ARFGSAMEKSGKMDVAEALELSEKLYLDMS-KTL-GSLMNIKNMSGHVSMKYLSRQEREK 1278
+ E++ ++ + E + + D + +TL G L GH S Q
Sbjct: 1134 QQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELA 1193
Query: 1279 VNQLRQRDLDLVFD----KITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAK 1334
+ + +D D ++ + + + RK L+ E++V L R + E ++ +
Sbjct: 1194 AFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKR 1253
Query: 1335 LEDDIYKEAEEKALLKEALERMEHQLCQEK----RINRAIRQQKVGTRKASLKMDQEREM 1390
L + E+E+ L+E L ++ + + A+R++ R+ + K E
Sbjct: 1254 L---VMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASEN 1310
Query: 1391 LRKETSSKSSQS 1402
LR+E +S++ ++
Sbjct: 1311 LRQELTSQAERA 1322
Score = 122 bits (305), Expect = 3e-27
Identities = 218/1030 (21%), Positives = 418/1030 (40%), Gaps = 135/1030 (13%)
Query: 236 EVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAK 295
E +R +E +++ +A L+ ++ QK +E Q + ++ ++ Q L E +
Sbjct: 660 ETARQEQHEAQAQ-----VAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVT 714
Query: 296 QKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQK- 354
+ ++ K + + + + + + +E S + K E + L+ + A G+ + LQ+
Sbjct: 715 KGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQL 774
Query: 355 --------DILAKD------------EQVQQLKEEVSHLKSQNKDKDHQLEALGS----R 390
++L ++ + +QL +EV+ + + +D + G+ +
Sbjct: 775 GEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQ 834
Query: 391 CSVLKEELKQEDAHRELREAQEKELKL---CKTQIQDMEKEMKKLRAELRKSCT---EQS 444
LKEE E A +EL+EA+EK + + QI + E+ +L A L ++ E+
Sbjct: 835 LMTLKEEC--EKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKE 892
Query: 445 VISRTLREK-SKVEEKLQEDSR---------RKLLQLQEMGNRESVIKINL--ERAVGQL 492
V ++ L + S ++EK+ S+ RK + QE +RE V + +R L
Sbjct: 893 VRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWL 952
Query: 493 EHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQ 552
E + + +T + + +E++ ++ QQ++ Q+E +++ Q
Sbjct: 953 EEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERG-QQEREVARLTQ 1011
Query: 553 EETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHL--QVSPPVSGLQKVVLDVLR 610
E + + M++ ++ + E LQ G + + +
Sbjct: 1012 ERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRG 1071
Query: 611 HALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGE-AR 669
+ ++E+E+L + + L K + + SG+ A A +G + EA R E ++
Sbjct: 1072 LEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSK 1131
Query: 670 ARGEAQSQNQATDGREGGKALEEYITQERNRAKETL----EEERKRMQELESLLAQQKKA 725
+ Q Q + D E E ER+ A ETL EE+ + + +S LA ++
Sbjct: 1132 LEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRE 1191
Query: 726 LAKSITQEKN-------------RVKEALEEEQTRVQELEERLA-RQKEVLESSIAHEKR 771
LA T+ ++ R ++ E + + + LEE ++ ++VLE E +
Sbjct: 1192 LAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKE--GESK 1249
Query: 772 KAKEALESEKRKVQDLENHLT--QQKEISESNIAYEKRKA--------KEAMEKEKKKVQ 821
+ K + +E K Q LE L Q + S S A E+ A +E EK++ +
Sbjct: 1250 ELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASE 1309
Query: 822 DLENRLTKQKEELE--------------LKEQKEDVLNNKLSDALAMVEETQKTK-ATES 866
+L LT Q E E KEQ L + + A+V E K +
Sbjct: 1310 NLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQ 1369
Query: 867 LKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQD------EQESQRHGFEE 920
L+AE A + ELE +K + L+ Q+ + L EQE
Sbjct: 1370 LQAEQAAAEKRHR-EELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRA 1428
Query: 921 EIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPM 980
E Y EQ+ S+ +K + + GE A L + ++ ++ V +
Sbjct: 1429 EKASYAEQL--------SMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQEL 1480
Query: 981 TESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNE-KQKM- 1038
A L Q+E S + + A ++ + R E +QK+
Sbjct: 1481 AAVRADAETR------LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLT 1534
Query: 1039 -ELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALE-EALRASQEKHRL--QLN 1094
++EQ V ++Q+K++ L +K+A + + ++LKA++ + + QE RL QLN
Sbjct: 1535 AQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLN 1594
Query: 1095 TEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKAL 1154
+ Q +K+ +Q+E T + Q+ Q + R E +Q++ K
Sbjct: 1595 ELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQE------QLRSLEQLQKENK-- 1646
Query: 1155 SELRARIKEL 1164
ELRA + L
Sbjct: 1647 -ELRAEAERL 1655
Score = 112 bits (281), Expect = 2e-24
Identities = 254/1278 (19%), Positives = 513/1278 (40%), Gaps = 223/1278 (17%)
Query: 235 KEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDA 294
K ++ +E E + +I +LQ+ ++ LSQ ++E+ Q Q + A
Sbjct: 449 KLLAERGHFEEEKQQLSSLITDLQSSISNLSQA----------KEELEQASQAHGARLTA 498
Query: 295 KQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQK 354
++ SL S+++ L T+ +++ E+ LK + + + A T
Sbjct: 499 ---QVASLTSELTTLNA--------TIQQQDQELAGLKQQAKEKQAQLAQT--------- 538
Query: 355 DILAKDEQVQQ-LKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHR-ELREAQE 412
L + EQ Q L+ +V L S K K+ QL+ + + +++ Q+ A E REA
Sbjct: 539 --LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASL 596
Query: 413 KELKLCKTQIQDMEKE--------MKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDS 464
+E Q++ +EKE ++L+ + Q+ +++ REK+++ K++E
Sbjct: 597 RERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEE-- 654
Query: 465 RRKLLQLQEMGNRESVIKINLERAVGQLE-HFRSQVIKATYG-RAKPFRDKPVTDQQLIE 522
L E +E + + V +LE RS+ KAT R +D+ Q ++
Sbjct: 655 ---LQACVETARQE---QHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALK 708
Query: 523 KITQVTEDNINFQQKKWT------------LQKETQLSNSKQEETTENIEKLRTSLDSCQ 570
+ +VT+ ++ ++++ L+ ET+ + + + +E+ R +
Sbjct: 709 ESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLE 768
Query: 571 ACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILP 630
A ++ +H + EV L++ + + + + E EQL++++
Sbjct: 769 ARLQQLGEAHQAETEV--------------LRRELAEAMAAQHTAESECEQLVKEVAAW- 813
Query: 631 SSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKAL 690
+++ + A + A + E E+ AR E Q + G E L
Sbjct: 814 ----RERYEDSQQEEAQYGAMFQEQLMTLKEECEK----ARQELQEAKEKVAGIESHSEL 865
Query: 691 EEYITQERN----------RAKETLEEERKRMQELE---SLLAQQKKALAKSITQEKNRV 737
+ I++++N RA + ++E+ R Q+L S L ++ A +K + + + V
Sbjct: 866 Q--ISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLV 923
Query: 738 KEALEEEQTRVQELEERLAR----QKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQ 793
++A E+++T +EL + AR Q E LE + + AL++ +R+ + + N L +
Sbjct: 924 RKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELER 983
Query: 794 -----------------QKEISESNIAYEKRKAKEAMEKEKKKVQDLE----NRLTKQKE 832
Q+E + + E+ +A+ + EK +LE N L +Q+
Sbjct: 984 LRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRV 1043
Query: 833 E-----------LELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALK------ 875
E L KE K+ L A ++E ++ + T E LA K
Sbjct: 1044 EFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHAS 1103
Query: 876 ----LNETLAELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQ 931
+E E T K+ + + ++ + Q++ +S E E E+
Sbjct: 1104 GSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSA 1163
Query: 932 HAQTIVSLEEKLQKVTQHHKKI---EGEIATL--KDNDPAPKEERPQDPLVAPMTESSAK 986
LEEK Q++ + + E+A K D + E+ + + E+ K
Sbjct: 1164 LETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERK 1223
Query: 987 DMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVL 1046
+ L +++ +++L ++ +L++ L A S S +LE+ + L
Sbjct: 1224 NSLISSLEEEVSILNRQVLEKEGESKELKR-LVMAESEKSQ-----------KLEERLRL 1271
Query: 1047 VQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQLNTEKE-------- 1098
+Q ++ S + A+ SS + ++ + L+ E R + E R +L ++ E
Sbjct: 1272 LQAETASNSA---RAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQE 1328
Query: 1099 -----QKPRKKTQTCDTSVQIEPVHTEAFSSS-----------QEQQSFSDLGVRCKGSR 1142
+K +K Q T +Q+E T+A S Q +Q+ ++ R
Sbjct: 1329 LKAWQEKFFQKEQALST-LQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE-------KR 1380
Query: 1143 HEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPD 1202
H E +++ K+A LRA EL +A+ ++ L K E Q++ +
Sbjct: 1381 HREELEQSKQAAGGLRA---ELLRAQ----RELGELIPLRQKVAEQERTAQQLRAEKASY 1433
Query: 1203 LPTLSRIE----ILAPQN-GLCNARFGSAMEKSGKMDVAEALELSE--KLYLDMSKTLGS 1255
LS ++ +LA +N GL ++D A + E + D L
Sbjct: 1434 AEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAE 1493
Query: 1256 LMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDV 1315
+ + ++ E KV L +R ++ +L Q+ + E R K V
Sbjct: 1494 VQREAQSTARELEVMTAKYEGAKVKVLEER--QRFQEERQKLTAQVEQLEVFQREQTKQV 1551
Query: 1316 EQLRR----SKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIR 1371
E+L + S + ++ Q ++ ++ + +E L+ L ++ QL Q++ +A
Sbjct: 1552 EELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKE---QAAE 1608
Query: 1372 QQKVGTRKASLKMDQERE 1389
K+ KA D +++
Sbjct: 1609 HYKLQMEKAKTHYDAKKQ 1626
Score = 98.2 bits (243), Expect = 5e-20
Identities = 151/699 (21%), Positives = 303/699 (43%), Gaps = 75/699 (10%)
Query: 733 EKNRVKEALEEEQTRVQELEERLARQKEVLESSIAH----EKRKAKEALESEKRKVQDLE 788
+ R+K+ L +E++ ELE LA +++L A ++R + AL +EK+ LE
Sbjct: 215 QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE 274
Query: 789 -NHLTQQKEISESNIA--YEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLN 845
L + ++ +ES +E K + ++ EK ++ N+L+++ +L K ++
Sbjct: 275 PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL 334
Query: 846 NKLSDALAMVEETQKTKATESL--KAESLALKLNETLAELETTKTKMIMVEERLILQQKM 903
+L DAL + E + +KAT+ K L +L+ L + + + K +++ +L ++
Sbjct: 335 QQLQDALNELTE-EHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEH 393
Query: 904 VKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEG--EIATLK 961
+ LQD ++ ++++ E +KQ A T+ + +LQ + + G E L
Sbjct: 394 LSQLQDNPPQEKGEVLGDVLQL-ETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLA 452
Query: 962 DNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEA 1021
+ +E++ L+ + S + + ++ A L+ Q + L +LT
Sbjct: 453 ERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ--VASLTSELTTL 510
Query: 1022 HSRMSDLRGEL---NEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKAL 1078
++ + EL ++ K + Q +QQQ + L+ ++ Q+SS +++K+++LK +
Sbjct: 511 NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEV 570
Query: 1079 EEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRC 1138
E A+++ H QL T E++ + Q+E + E + + Q +
Sbjct: 571 AEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA 630
Query: 1139 KGSRHEEVIQRQKKALSELRARIKEL----EKARSPDHKDHQNESFLDLKNLRMENNVQK 1194
+ S V Q Q++ +EL +++EL E AR H+ + L+L+ LR E QK
Sbjct: 631 RDSAQTSVTQAQREK-AELSRKVEELQACVETARQEQHEAQAQVAELELQ-LRSEQ--QK 686
Query: 1195 ILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLG 1254
+ A EK + +AL+ S K+ T G
Sbjct: 687 ------------------------ATEKERVAQEKDQLQEQLQALKESLKV------TKG 716
Query: 1255 SLMNIKNMSGHV------SMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELL 1308
SL K + + L + R V Q ++ +L ++ + K R ++L
Sbjct: 717 SLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGR-KGLEARLQQLG 775
Query: 1309 RGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEAL---ERMEHQLCQEKR 1365
++ + E LRR E+ ++ A+ E+E + L+KE ER E +E +
Sbjct: 776 EAHQAETEVLRR-----ELAEAMAAQHT----AESECEQLVKEVAAWRERYEDSQQEEAQ 826
Query: 1366 INRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSLL 1404
++Q + ++ K QE + +++ + S S L
Sbjct: 827 YGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSEL 865
Score = 50.8 bits (120), Expect = 9e-06
Identities = 117/562 (20%), Positives = 226/562 (40%), Gaps = 100/562 (17%)
Query: 226 KDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKC 285
K+ +I L +EVS L+ +E + + + L +E SQK+ E R + E +
Sbjct: 1223 KNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERL--RLLQAETASNS 1280
Query: 286 QVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAIT 345
E A ++E+QSL+ + +V + L + E+TS E L ++
Sbjct: 1281 ARAAERSSALREEVQSLREEAEK-----QRVASENLRQ---ELTSQAERAEELGQE---- 1328
Query: 346 SGMVSSLQKDILAKDEQVQQLKEE---VSHLKSQNKDKDHQLEALGSRCSVLKEELKQED 402
+ + Q+ K++ + L+ E L S+ H + L + E+ E
Sbjct: 1329 ---LKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQA------EQAAAEK 1379
Query: 403 AHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLR-EKSKVEEKLQ 461
HRE E ++ + ++ ++E+ +L LR+ EQ ++ LR EK+ E+L
Sbjct: 1380 RHREELEQSKQAAGGLRAELLRAQRELGEL-IPLRQKVAEQERTAQQLRAEKASYAEQLS 1438
Query: 462 EDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLI 521
+ L +E R +G+ + Q ++ +A+ ++ +
Sbjct: 1439 MLKKAHGLLAEE------------NRGLGERANLGRQFLEVELDQAR---------EKYV 1477
Query: 522 EKITQVTEDNINFQQKKWTLQKETQLSNSKQE--ETTENIEKLRTSLDSCQACMKISCCS 579
+++ V D ET+L+ ++E T +E + + +
Sbjct: 1478 QELAAVRAD------------AETRLAEVQREAQSTARELEVMTAKYEGAKV-------- 1517
Query: 580 HDLKKEVDLLQHLQVSPPVSGLQKVVLDVL-RHALSWLEEVEQLLRDLGILPSSPNKDQV 638
K ++ Q Q Q L+V R +EE+ + L D S +V
Sbjct: 1518 ----KVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLAD------SDQASKV 1567
Query: 639 QQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQER 698
QQ A +A G ++ EA+R +A+ E Q+Q + +A E Y Q
Sbjct: 1568 QQ-----QKLKAVQAQGGESQQ-EAQRLQAQL-NELQAQLSQKE-----QAAEHYKLQ-M 1614
Query: 699 NRAKETLEEERKRMQELESLL--AQQKKALAKSITQEKNRVKEALEEEQTRVQELEE--- 753
+AK + ++++ QEL+ L +Q + K + E R+ L++ + +E E+
Sbjct: 1615 EKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCR 1674
Query: 754 RLARQKEVLESSIAHEKRKAKE 775
L Q LE+ +AH ++ ++
Sbjct: 1675 HLTAQVRSLEAQVAHADQQLRD 1696
Score = 45.8 bits (107), Expect = 3e-04
Identities = 51/271 (18%), Positives = 111/271 (40%), Gaps = 37/271 (13%)
Query: 260 EVAELSQKVSETTTSRQNEKEISQKCQV---LDEDIDAKQKEIQSLKSQISALQKGYSKV 316
E A L ++ E + EK + + V + + Q+E QS ++ + Y
Sbjct: 1456 ERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGA 1515
Query: 317 LCQTLSERN---SEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHL 373
+ L ER E L + E L+ + V L K + D+ + ++++ +
Sbjct: 1516 KVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAV 1575
Query: 374 KSQNKDKDHQLEALGSRCSVLKEELKQED--------------AHRELREAQEKELKLCK 419
++Q + + + L ++ + L+ +L Q++ H + ++ Q +EL+
Sbjct: 1576 QAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL 1635
Query: 420 TQIQDMEKEMKKLRA-------ELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQ 472
++ ++KE K+LRA EL+++ + +T R + L+ QL+
Sbjct: 1636 RSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLR 1695
Query: 473 EMG----------NRESVIKINLERAVGQLE 493
++G +RE K L+ ++ L+
Sbjct: 1696 DLGKFQVATDALKSREPQAKPQLDLSIDSLD 1726
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 142 bits (359), Expect = 2e-33
Identities = 234/1100 (21%), Positives = 480/1100 (43%), Gaps = 188/1100 (17%)
Query: 226 KDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNE------- 278
K E+ +L + +RL + E + + ++ +L +++ E +RQ
Sbjct: 917 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976
Query: 279 ----KEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNE 334
K++ + V+D+ + KE + L+ +IS L ++ E+ +T LKN+
Sbjct: 977 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE-----EEKAKNLTKLKNK 1031
Query: 335 GENL-----------KRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQ 383
E++ ++ + L+ D EQ+ L+ +++ LK Q K+ +
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 384 LEA---------------------LGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQI 422
L+A L S L+E+L E A R E Q+++L
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG------ 1145
Query: 423 QDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIK 482
+++E +L L + T+Q + ++ +E + +++ L E++R Q+QEM + +
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA- 1204
Query: 483 INLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQ 542
+E QLE F+ RAK DK ++Q +EK +N + + L
Sbjct: 1205 --VEELTEQLEQFK---------RAKANLDK---NKQTLEK------ENADLAGELRVLG 1244
Query: 543 KETQLSNSKQEETTENIEKLRTSL-DSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGL 601
+ Q K+++ +++L++ D +A +++ H L+ EV+ + + ++
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-LNEAEGKA 1303
Query: 602 QKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREG 661
K+ DV + S L++ ++LL +++ +Q S + S ++
Sbjct: 1304 IKLAKDVASLS-SQLQDTQELL-----------QEETRQKLNVSTKLRQLEEERNSLQDQ 1351
Query: 662 EAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQ-ELESLLA 720
E EA+ E + K L+++ + E LEE +KR Q E+E+L
Sbjct: 1352 LDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS-----TVEALEEGKKRFQKEIENLTQ 1406
Query: 721 Q--QKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALE 778
Q +K A + + KNR+++ L+ +L L Q++++ + LE
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELD-------DLVVDLDNQRQLVSN------------LE 1447
Query: 779 SEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKV---QDLENRLTKQKEELE 835
++RK L L ++K IS R EA EKE K + + LE L + KEELE
Sbjct: 1448 KKQRKFDQL---LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-EAKEELE 1503
Query: 836 -----LKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKM 890
LK + ED++++K D V E +K+K + E + +L E EL+ T+
Sbjct: 1504 RTNKMLKAEMEDLVSSK-DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 891 IMVEERL-ILQQKMVKALQ--DEQ-ESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQK- 945
+ +E + L+ + + LQ DEQ E +R + ++ EY+ +++ +E+ Q+
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE---------DERKQRA 1613
Query: 946 -VTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEI 1004
KK+EG++ L+ A + ++ + + + A+ ++ ++D A++ EI
Sbjct: 1614 LAAAAKKKLEGDLKDLELQ--ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 1005 LSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQ- 1063
+ + K K L E M+L++++ ++ K+ + KE++A+
Sbjct: 1672 FATAKENEKKAKSL---------------EADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 1064 -MSSL-----VEKKDRELKA----LEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQ 1113
SSL ++ + R L+A LEE L +E+ ++ +++ +K ++ + +
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEEL--EEEQGNMEAMSDRVRKATQQAEQLSNELA 1774
Query: 1114 IEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQ-KKALSELRARIKELEKARSPDH 1172
E + S+++Q + +R K E ++ + K ++ L A+I +LE+ +
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 1173 KDHQNESFLDLKNLRM-ENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSG 1231
++ Q + K+L+ + +++ILL + + + + A + G+A K
Sbjct: 1835 REKQAAT----KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK--------GNARVKQL 1882
Query: 1232 KMDVAEALELSEKLYLDMSK 1251
K + EA E S+++ + K
Sbjct: 1883 KRQLEEAEEESQRINANRRK 1902
Score = 140 bits (353), Expect = 9e-33
Identities = 222/1127 (19%), Positives = 487/1127 (43%), Gaps = 149/1127 (13%)
Query: 349 VSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELR 408
V+ ++++ AK++++Q+ KE +++ K+ + + L ++L+E+L+ E
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET--ELYA 904
Query: 409 EAQEKELKLC--KTQIQDMEKEMK-KLRAELRKSCTEQSVISRTLREKSKVEEKL-QEDS 464
EA+E ++L K +++++ EM+ +L E + Q+ + ++ +EE+L +E++
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 465 RRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKI 524
R+ LQL+ K+ E + +LE +++ K +++ + ++++ +
Sbjct: 965 ARQKLQLE---------KVTAEAKIKKLE---DEILVMDDQNNKLSKERKLLEERISDLT 1012
Query: 525 TQVTEDN------INFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCC 578
T + E+ + K ++ E ++ K+E++ + +EKL+ L+ +
Sbjct: 1013 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA 1072
Query: 579 SHDLKKEVDLLQHLQVSPPVSGLQKVV------LDVLRHALSWLEEVEQLLRDLGILPSS 632
DL+ ++ L+ +Q++ LQ + + +AL + E+E + DL
Sbjct: 1073 --DLQAQIAELK-MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL------ 1123
Query: 633 PNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREG------ 686
Q S +A A K G E EA + E ++ + Q +
Sbjct: 1124 ----QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1179
Query: 687 GKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKE------- 739
KAL+E + +E ++ + ++EL L Q K+A A ++ KE
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 740 --ALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEI 797
L + + V+ +++L Q + L+S + +R A+ L + K+Q+ +T
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER-ARAELNDKVHKLQNEVESVTGMLNE 1298
Query: 798 SESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELK----EQKEDVLNNKLSDALA 853
+E A + K ++ + + Q+L T+QK + K E++ + L ++L + +
Sbjct: 1299 AEGK-AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1357
Query: 854 MVEETQKTKATESLKAESLALKLNE---TLAELETTKTKMIMVEERLILQQKMVKALQDE 910
+ ++ +T +++ KL + T+ LE K + E L Q + A D+
Sbjct: 1358 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1417
Query: 911 QESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQ---HHKKIEGEIATLKDNDPAP 967
E ++ ++E+ + + Q + +LE+K +K Q K I + A + D A
Sbjct: 1418 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA--DERDRAE 1475
Query: 968 KEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSD 1027
E R E K ++ +++ L A++E+ +++ +DL + +
Sbjct: 1476 AEAR----------EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG- 1524
Query: 1028 LRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQE 1087
K ELE++ ++ Q +E+ E++ E L+ +AL+ E
Sbjct: 1525 -------KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1577
Query: 1088 KH---RLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQE--QQSFSDLGVRCKGS- 1141
+ R + N EK ++ +++ +T ++ E +++++ + DL ++ +
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 1142 -RHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLK-NLRMENNVQKILLDA 1199
EE I++ +K ++++ +ELE AR+ ++E F K N + +++ L+
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARA-----SRDEIFATAKENEKKAKSLEADLMQL 1692
Query: 1200 KPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNI 1259
+ DL +A E++ K E EL+E+L +S
Sbjct: 1693 QEDL---------------------AAAERARKQADLEKEELAEELASSLSGRNALQDEK 1731
Query: 1260 KNMSGHV------------SMKYLSRQEREKVNQLRQRDLDLVFDKITQLKN-----QLG 1302
+ + + +M+ +S + R+ Q Q +L ++ T KN QL
Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 1303 RKEELLRGYEKDVEQLRRSKV--SIEMYQSQVAKLEDDIYKEAEEKAL----LKEALERM 1356
R+ + LR ++E +SK +I ++++A+LE+ + +EA EK LK+ +++
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851
Query: 1357 EHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
+ L Q + + Q K K + ++ Q + L E + + SQ +
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL--EEAEEESQRI 1896
Score = 127 bits (318), Expect = 1e-28
Identities = 204/958 (21%), Positives = 411/958 (42%), Gaps = 129/958 (13%)
Query: 232 LLGKEVSRLSDYEIESKYKDVIIANLQNE----VAELSQKVSETTTSRQNEKEISQKCQV 287
LL + +S L+ E + K + L+N+ ++EL ++ + SRQ +++ +K
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--- 1059
Query: 288 LDEDIDAKQKEIQSLKSQISALQKGYSKV---LCQTLSERNSEITSLKNEGENLKRDNAI 344
L+ D ++I L++QI+ L+ +K L L+ + EI N + ++
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE---- 1115
Query: 345 TSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAH 404
G +S LQ+D+ E+ + K E Q +D +LEAL + L++ L
Sbjct: 1116 LEGHISDLQEDL--DSERAARNKAE-----KQKRDLGEELEALKTE---LEDTLDSTATQ 1165
Query: 405 RELREAQEKELKLCKTQIQDMEK-------EMKKLRAELRKSCTEQ-SVISRTLREKSKV 456
+ELR +E+E+ + K + + + EM++ A+ + TEQ R K
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 457 EEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVT 516
++ L++++ +L+ +G + ++ ++ Q++ +S+ RA+ DK
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE-LNDKVHK 1284
Query: 517 DQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIE-----KLRTSLDSCQA 571
Q +E +T + + + K L K+ +S+ ++T E ++ KL S Q
Sbjct: 1285 LQNEVESVTGMLNEA---EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1341
Query: 572 CMKISCCSHDLKKEVDLLQHLQVSPPVSGLQ----KVVLDVLRHALSWLEE--------V 619
+ + L +E++ Q+L+ +Q K L + LEE +
Sbjct: 1342 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1401
Query: 620 EQLLRDLGILPSS-----PNKDQVQQFSGNSAVFTAGKAAGASGREGEAER--------- 665
E L + ++ K+++QQ + V + S E + +
Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461
Query: 666 ------GEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLL 719
+ R R EA+++ + T +ALEE + AKE LE K ++ L
Sbjct: 1462 NISSKYADERDRAEAEAREKETKALSLARALEEAL-----EAKEELERTNKMLKAEMEDL 1516
Query: 720 AQQKKALAKSITQ---EKNRVKEALEEEQTRVQELEERL-ARQKEVLESSIAHEKRKAKE 775
K + K++ + K ++ +EE +T+++ELE+ L A + L + + K +
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576
Query: 776 ALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKK-----VQDLE---NRL 827
+ + R Q+ E Q+++ E E + + A+ KK ++DLE +
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1636
Query: 828 TKQKEEL-----ELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLA---LKLNET 879
K +EE +L+ Q +D +L DA A +E T KA+SL ++L E
Sbjct: 1637 IKGREEAIKQLRKLQAQMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 880 LAELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSL 939
LA E + + + +E L + + ++ + ++ E I + +E++++ + ++
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755
Query: 940 EEKLQKVTQHHKKIEGEIATLKD----NDPAPKE-ERPQDPLVAPMTE-SSAKDMAYEHL 993
++++K TQ +++ E+AT + N+ A ++ ER L + + E A ++
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815
Query: 994 IDDLLA--AQKEILSQQEVIMK--LRKDLTEAHSRMSDLRGELNEKQKM------ELEQN 1043
I L A AQ E +QE K K L + ++ ++ ++ +++KM + E+
Sbjct: 1816 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG 1875
Query: 1044 VVLVQQQSKELSVLKEKMAQMSSLVEKKDREL--------------KALEEALRASQE 1087
V+Q ++L +E+ ++++ K REL AL+ LR E
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 105 bits (261), Expect = 4e-22
Identities = 193/937 (20%), Positives = 385/937 (41%), Gaps = 112/937 (11%)
Query: 521 IEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSH 580
++ + QVT Q K+ LQK T+ K E + +E+ + L + +
Sbjct: 841 VKPLLQVTRQEEEMQAKEDELQK-TKERQQKAENELKELEQKHSQLTE-----EKNLLQE 894
Query: 581 DLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHAL-SWLEEVEQLLRDLGILPSSPNKDQVQ 639
L+ E +L + +K L+ + H + + LEE E D G + K Q
Sbjct: 895 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE----DRGQQLQAERKKMAQ 950
Query: 640 QFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYI---TQ 696
Q E + E EA AR + Q + + + K LE+ I
Sbjct: 951 QM---------------LDLEEQLEEEEA-ARQKLQLEKVTAEAKI--KKLEDEILVMDD 992
Query: 697 ERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLA 756
+ N+ + + +R+ +L + LA++++ AK++T+ KN+ + + E + R+++ EE+
Sbjct: 993 QNNKLSKERKLLEERISDLTTNLAEEEEK-AKNLTKLKNKHESMISELEVRLKK-EEKSR 1050
Query: 757 RQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKE 816
++ E L+ + + E + + ++ +L+ L +++E ++ +A R E +K
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA---RLDDEIAQKN 1107
Query: 817 K--KKVQDLENRLTKQKEELE--------LKEQKEDV------LNNKLSDALAMVEETQK 860
KK+++LE ++ +E+L+ ++QK D+ L +L D L Q+
Sbjct: 1108 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167
Query: 861 TKATESLKAESLALKLNETL----AELETTKTKMIMVEERLILQQKMVKALQDEQESQRH 916
+A + L L+E A+++ + K E L Q + K + + +
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Query: 917 GFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKI-----EGEIATLKDNDPAPKEER 971
E+E + +++ Q +E K +K+ +++ +GE A + ND K +
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1287
Query: 972 PQDPLVAPMTESS------AKDMA--YEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHS 1023
+ + + E+ AKD+A L D Q+E + V KLR+ E +S
Sbjct: 1288 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1347
Query: 1024 RMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEK----KDRELKALE 1079
L E+ KQ +E + + +Q LS K+K+ +S VE K R K +E
Sbjct: 1348 LQDQLDEEMEAKQNLERHISTLNIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 1080 EALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCK 1139
+ +EK EK K R + + D V ++ + ++Q+ F L K
Sbjct: 1403 NLTQQYEEKAAAYDKLEK-TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461
Query: 1140 GSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDA 1199
+ +R + K L AR+ + E L+ N ++ ++ L+ +
Sbjct: 1462 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE-LERTNKMLKAEMED-LVSS 1519
Query: 1200 KPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSL--- 1256
K D+ + L + K+ ++ + L+ +E L + + +L
Sbjct: 1520 KDDVG--KNVHELEKSKRALETQMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575
Query: 1257 ----MNIKNMSGHVSMKYLSRQ----EREKVNQLRQRDLDLVFDKITQ--LKNQLGRKEE 1306
+ ++ + L RQ E E ++ +QR L K + LK+ + +
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 1307 LLRGYEKDVEQLRRSKVSIEMYQSQVAKL---EDDIYKEAEEKALLKEALERMEHQLCQE 1363
++G E+ ++QLR+ + ++ +Q ++ D+I+ A+E ++LE QL
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL--- 1692
Query: 1364 KRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSS 1400
++ +A + D E+E L +E +S S
Sbjct: 1693 -------QEDLAAAERARKQADLEKEELAEELASSLS 1722
Score = 104 bits (259), Expect = 7e-22
Identities = 165/810 (20%), Positives = 354/810 (43%), Gaps = 126/810 (15%)
Query: 691 EEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQE 750
EE + + + ++T E ++K EL+ L +QK + +T+EKN ++E L+ E E
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKEL--EQKHS---QLTEEKNLLQEQLQAETELYAE 905
Query: 751 LEE---RLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKR 807
EE RLA +K+ LE I HE + LE E+ + Q L+ ++K++++ + E
Sbjct: 906 AEEMRVRLAAKKQELEE-ILHEM---EARLEEEEDRGQQLQ---AERKKMAQQMLDLE-- 956
Query: 808 KAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVL-----NNKLSDALAMVEETQKTK 862
E +E+E+ Q L+ L K E ++K+ ++++L NNKLS ++EE
Sbjct: 957 ---EQLEEEEAARQKLQ--LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011
Query: 863 ATESLKAESLALKLNETLAELETTKTKMIM-VEERLILQQKM---VKALQDEQESQRHGF 918
T + E A + L +L+ MI +E RL ++K ++ L+ + E F
Sbjct: 1012 TTNLAEEEEKA----KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 919 EEEIMEYKEQIKQHAQTIVSLEEKLQ--------KVTQHH------KKIEGEIATLKDN- 963
E+I + + QI + + EE+LQ ++ Q + +++EG I+ L+++
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 964 -------DPAPKEERP------------QDPLVAPMTESSAKDMAYEHLIDDLLAAQKEI 1004
+ A K++R +D L + T+ + + + A +E
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187
Query: 1005 LSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQM 1064
S + + ++R+ +A +++ + E ++ K L++N +++++ +L+ + Q
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTE-QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246
Query: 1065 SSLVEKKDRELKALEEALR---ASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEA 1121
VE K ++L+A + L+ + E+ R +LN +K K + + ++ + + +A
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELN-DKVHKLQNEVES--VTGMLNEAEGKA 1303
Query: 1122 FSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARS--PDHKDHQNES 1179
+++ S S + +E++Q + + + ++++LE+ R+ D D + E+
Sbjct: 1304 IKLAKDVASLSS-----QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358
Query: 1180 FLDLKNLRMENNVQKILLDAKPDLPTLS---------------RIEILAPQNGLCNARFG 1224
+L+ N+Q L D+K L + IE L Q A +
Sbjct: 1359 KQNLERHISTLNIQ--LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 1225 SAMEKSGKM-----DVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKV 1279
+ ++ D+ L+ +L ++ K + ++S KY ++R +
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 1280 ----NQLRQRDLDLVFDKITQLKNQLGRKEELLRG-----------YEKDVEQLRRSK-- 1322
+ + L ++ + K +L R ++L+ K+V +L +SK
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1536
Query: 1323 --VSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKA 1380
+E ++Q+ +LED++ + K L+ ++ ++ Q E+ + Q + R+
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQNEEKRRQL 1594
Query: 1381 SLKMDQEREMLRKETSSKSSQSLLHSKPSG 1410
++ + L E ++ + K G
Sbjct: 1595 QRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Score = 89.0 bits (219), Expect = 3e-17
Identities = 141/709 (19%), Positives = 291/709 (41%), Gaps = 116/709 (16%)
Query: 242 DYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQS 301
D E+E+K NL+ ++ L+ ++S+ S++ ++ + + L+E QKEI++
Sbjct: 1353 DEEMEAKQ------NLERHISTLNIQLSD---SKKKLQDFASTVEALEEGKKRFQKEIEN 1403
Query: 302 LKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDE 361
L Q Y K L +T + E+ L + +N ++ +VS+L+K K
Sbjct: 1404 LTQQYEEKAAAYDK-LEKTKNRLQQELDDLVVDLDNQRQ-------LVSNLEK----KQR 1451
Query: 362 QVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQ 421
+ QL E ++ S+ D+ + EA ++E K R L EA E +
Sbjct: 1452 KFDQLLAEEKNISSKYADERDRAEA-----EAREKETKALSLARALEEALEAK------- 1499
Query: 422 IQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESV- 480
+++E+ K L+AE+ + + + + + E K + L+ QL+E+ +
Sbjct: 1500 -EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1558
Query: 481 ------IKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINF 534
+++N++ GQ E RD D+Q EK Q+ +
Sbjct: 1559 EDAKLRLEVNMQALKGQFE-----------------RDLQARDEQNEEKRRQLQRQLHEY 1601
Query: 535 QQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQV 594
+ + +K+ L+ + +++ +++ L DS +K + ++ L+
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSA------------IKGREEAIKQLRK 1649
Query: 595 SPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAA 654
LQ + D R E + RD + N+ + + + AA
Sbjct: 1650 ------LQAQMKDFQREL-----EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 655 GASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQE 714
R+ E A A S + ++ + LE I Q +E LEEE+ M+
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ----LEEELEEEQGNMEA 1754
Query: 715 LESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELE---ERLARQKEVLESSIAHE-- 769
+ + + TQ+ ++ L E++ Q+ E ++L RQ + L S + HE
Sbjct: 1755 MSDRV--------RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL-HEME 1805
Query: 770 ---KRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENR 826
K K K + + + K+ LE + Q+ A EK+ A ++++++ KK++++ +
Sbjct: 1806 GAVKSKFKSTIAALEAKIAQLEEQVEQE--------AREKQAATKSLKQKDKKLKEILLQ 1857
Query: 827 LTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETT 886
+ +++ E +++ + N ++ +EE ++ ES + + KL L E T
Sbjct: 1858 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE----ESQRINANRRKLQRELD--EAT 1911
Query: 887 KTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQT 935
++ M E L+ K+ + + R ++E + ++ T
Sbjct: 1912 ESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDT 1960
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 142 bits (359), Expect = 2e-33
Identities = 234/1100 (21%), Positives = 480/1100 (43%), Gaps = 188/1100 (17%)
Query: 226 KDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNE------- 278
K E+ +L + +RL + E + + ++ +L +++ E +RQ
Sbjct: 924 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983
Query: 279 ----KEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNE 334
K++ + V+D+ + KE + L+ +IS L ++ E+ +T LKN+
Sbjct: 984 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE-----EEKAKNLTKLKNK 1038
Query: 335 GENL-----------KRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQ 383
E++ ++ + L+ D EQ+ L+ +++ LK Q K+ +
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 384 LEA---------------------LGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQI 422
L+A L S L+E+L E A R E Q+++L
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG------ 1152
Query: 423 QDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIK 482
+++E +L L + T+Q + ++ +E + +++ L E++R Q+QEM + +
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA- 1211
Query: 483 INLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQ 542
+E QLE F+ RAK DK ++Q +EK +N + + L
Sbjct: 1212 --VEELTEQLEQFK---------RAKANLDK---NKQTLEK------ENADLAGELRVLG 1251
Query: 543 KETQLSNSKQEETTENIEKLRTSL-DSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGL 601
+ Q K+++ +++L++ D +A +++ H L+ EV+ + + ++
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-LNEAEGKA 1310
Query: 602 QKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREG 661
K+ DV + S L++ ++LL +++ +Q S + S ++
Sbjct: 1311 IKLAKDVASLS-SQLQDTQELL-----------QEETRQKLNVSTKLRQLEEERNSLQDQ 1358
Query: 662 EAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQ-ELESLLA 720
E EA+ E + K L+++ + E LEE +KR Q E+E+L
Sbjct: 1359 LDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS-----TVEALEEGKKRFQKEIENLTQ 1413
Query: 721 Q--QKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALE 778
Q +K A + + KNR+++ L+ +L L Q++++ + LE
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELD-------DLVVDLDNQRQLVSN------------LE 1454
Query: 779 SEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKV---QDLENRLTKQKEELE 835
++RK L L ++K IS R EA EKE K + + LE L + KEELE
Sbjct: 1455 KKQRKFDQL---LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-EAKEELE 1510
Query: 836 -----LKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKM 890
LK + ED++++K D V E +K+K + E + +L E EL+ T+
Sbjct: 1511 RTNKMLKAEMEDLVSSK-DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 891 IMVEERL-ILQQKMVKALQ--DEQ-ESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQK- 945
+ +E + L+ + + LQ DEQ E +R + ++ EY+ +++ +E+ Q+
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE---------DERKQRA 1620
Query: 946 -VTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEI 1004
KK+EG++ L+ A + ++ + + + A+ ++ ++D A++ EI
Sbjct: 1621 LAAAAKKKLEGDLKDLELQ--ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 1005 LSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQ- 1063
+ + K K L E M+L++++ ++ K+ + KE++A+
Sbjct: 1679 FATAKENEKKAKSL---------------EADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 1064 -MSSL-----VEKKDRELKA----LEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQ 1113
SSL ++ + R L+A LEE L +E+ ++ +++ +K ++ + +
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEEL--EEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 1114 IEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQ-KKALSELRARIKELEKARSPDH 1172
E + S+++Q + +R K E ++ + K ++ L A+I +LE+ +
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 1173 KDHQNESFLDLKNLRM-ENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSG 1231
++ Q + K+L+ + +++ILL + + + + A + G+A K
Sbjct: 1842 REKQAAT----KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK--------GNARVKQL 1889
Query: 1232 KMDVAEALELSEKLYLDMSK 1251
K + EA E S+++ + K
Sbjct: 1890 KRQLEEAEEESQRINANRRK 1909
Score = 140 bits (353), Expect = 9e-33
Identities = 222/1127 (19%), Positives = 487/1127 (43%), Gaps = 149/1127 (13%)
Query: 349 VSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELR 408
V+ ++++ AK++++Q+ KE +++ K+ + + L ++L+E+L+ E
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET--ELYA 911
Query: 409 EAQEKELKLC--KTQIQDMEKEMK-KLRAELRKSCTEQSVISRTLREKSKVEEKL-QEDS 464
EA+E ++L K +++++ EM+ +L E + Q+ + ++ +EE+L +E++
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 465 RRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKI 524
R+ LQL+ K+ E + +LE +++ K +++ + ++++ +
Sbjct: 972 ARQKLQLE---------KVTAEAKIKKLE---DEILVMDDQNNKLSKERKLLEERISDLT 1019
Query: 525 TQVTEDN------INFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCC 578
T + E+ + K ++ E ++ K+E++ + +EKL+ L+ +
Sbjct: 1020 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA 1079
Query: 579 SHDLKKEVDLLQHLQVSPPVSGLQKVV------LDVLRHALSWLEEVEQLLRDLGILPSS 632
DL+ ++ L+ +Q++ LQ + + +AL + E+E + DL
Sbjct: 1080 --DLQAQIAELK-MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL------ 1130
Query: 633 PNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREG------ 686
Q S +A A K G E EA + E ++ + Q +
Sbjct: 1131 ----QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1186
Query: 687 GKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKE------- 739
KAL+E + +E ++ + ++EL L Q K+A A ++ KE
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 740 --ALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEI 797
L + + V+ +++L Q + L+S + +R A+ L + K+Q+ +T
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER-ARAELNDKVHKLQNEVESVTGMLNE 1305
Query: 798 SESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELK----EQKEDVLNNKLSDALA 853
+E A + K ++ + + Q+L T+QK + K E++ + L ++L + +
Sbjct: 1306 AEGK-AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1364
Query: 854 MVEETQKTKATESLKAESLALKLNE---TLAELETTKTKMIMVEERLILQQKMVKALQDE 910
+ ++ +T +++ KL + T+ LE K + E L Q + A D+
Sbjct: 1365 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1424
Query: 911 QESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQ---HHKKIEGEIATLKDNDPAP 967
E ++ ++E+ + + Q + +LE+K +K Q K I + A + D A
Sbjct: 1425 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA--DERDRAE 1482
Query: 968 KEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSD 1027
E R E K ++ +++ L A++E+ +++ +DL + +
Sbjct: 1483 AEAR----------EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG- 1531
Query: 1028 LRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQE 1087
K ELE++ ++ Q +E+ E++ E L+ +AL+ E
Sbjct: 1532 -------KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584
Query: 1088 KH---RLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQE--QQSFSDLGVRCKGS- 1141
+ R + N EK ++ +++ +T ++ E +++++ + DL ++ +
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 1142 -RHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLK-NLRMENNVQKILLDA 1199
EE I++ +K ++++ +ELE AR+ ++E F K N + +++ L+
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARA-----SRDEIFATAKENEKKAKSLEADLMQL 1699
Query: 1200 KPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNI 1259
+ DL +A E++ K E EL+E+L +S
Sbjct: 1700 QEDL---------------------AAAERARKQADLEKEELAEELASSLSGRNALQDEK 1738
Query: 1260 KNMSGHV------------SMKYLSRQEREKVNQLRQRDLDLVFDKITQLKN-----QLG 1302
+ + + +M+ +S + R+ Q Q +L ++ T KN QL
Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 1303 RKEELLRGYEKDVEQLRRSKV--SIEMYQSQVAKLEDDIYKEAEEKAL----LKEALERM 1356
R+ + LR ++E +SK +I ++++A+LE+ + +EA EK LK+ +++
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1858
Query: 1357 EHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
+ L Q + + Q K K + ++ Q + L E + + SQ +
Sbjct: 1859 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL--EEAEEESQRI 1903
Score = 127 bits (318), Expect = 1e-28
Identities = 204/958 (21%), Positives = 411/958 (42%), Gaps = 129/958 (13%)
Query: 232 LLGKEVSRLSDYEIESKYKDVIIANLQNE----VAELSQKVSETTTSRQNEKEISQKCQV 287
LL + +S L+ E + K + L+N+ ++EL ++ + SRQ +++ +K
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--- 1066
Query: 288 LDEDIDAKQKEIQSLKSQISALQKGYSKV---LCQTLSERNSEITSLKNEGENLKRDNAI 344
L+ D ++I L++QI+ L+ +K L L+ + EI N + ++
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE---- 1122
Query: 345 TSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAH 404
G +S LQ+D+ E+ + K E Q +D +LEAL + L++ L
Sbjct: 1123 LEGHISDLQEDL--DSERAARNKAE-----KQKRDLGEELEALKTE---LEDTLDSTATQ 1172
Query: 405 RELREAQEKELKLCKTQIQDMEK-------EMKKLRAELRKSCTEQ-SVISRTLREKSKV 456
+ELR +E+E+ + K + + + EM++ A+ + TEQ R K
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 457 EEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVT 516
++ L++++ +L+ +G + ++ ++ Q++ +S+ RA+ DK
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE-LNDKVHK 1291
Query: 517 DQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIE-----KLRTSLDSCQA 571
Q +E +T + + + K L K+ +S+ ++T E ++ KL S Q
Sbjct: 1292 LQNEVESVTGMLNEA---EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1348
Query: 572 CMKISCCSHDLKKEVDLLQHLQVSPPVSGLQ----KVVLDVLRHALSWLEE--------V 619
+ + L +E++ Q+L+ +Q K L + LEE +
Sbjct: 1349 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1408
Query: 620 EQLLRDLGILPSS-----PNKDQVQQFSGNSAVFTAGKAAGASGREGEAER--------- 665
E L + ++ K+++QQ + V + S E + +
Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468
Query: 666 ------GEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLL 719
+ R R EA+++ + T +ALEE + AKE LE K ++ L
Sbjct: 1469 NISSKYADERDRAEAEAREKETKALSLARALEEAL-----EAKEELERTNKMLKAEMEDL 1523
Query: 720 AQQKKALAKSITQ---EKNRVKEALEEEQTRVQELEERL-ARQKEVLESSIAHEKRKAKE 775
K + K++ + K ++ +EE +T+++ELE+ L A + L + + K +
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Query: 776 ALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKK-----VQDLE---NRL 827
+ + R Q+ E Q+++ E E + + A+ KK ++DLE +
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643
Query: 828 TKQKEEL-----ELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLA---LKLNET 879
K +EE +L+ Q +D +L DA A +E T KA+SL ++L E
Sbjct: 1644 IKGREEAIKQLRKLQAQMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 880 LAELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSL 939
LA E + + + +E L + + ++ + ++ E I + +E++++ + ++
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762
Query: 940 EEKLQKVTQHHKKIEGEIATLKD----NDPAPKE-ERPQDPLVAPMTE-SSAKDMAYEHL 993
++++K TQ +++ E+AT + N+ A ++ ER L + + E A ++
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822
Query: 994 IDDLLA--AQKEILSQQEVIMK--LRKDLTEAHSRMSDLRGELNEKQKM------ELEQN 1043
I L A AQ E +QE K K L + ++ ++ ++ +++KM + E+
Sbjct: 1823 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG 1882
Query: 1044 VVLVQQQSKELSVLKEKMAQMSSLVEKKDREL--------------KALEEALRASQE 1087
V+Q ++L +E+ ++++ K REL AL+ LR E
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 105 bits (261), Expect = 4e-22
Identities = 193/937 (20%), Positives = 385/937 (41%), Gaps = 112/937 (11%)
Query: 521 IEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSH 580
++ + QVT Q K+ LQK T+ K E + +E+ + L + +
Sbjct: 848 VKPLLQVTRQEEEMQAKEDELQK-TKERQQKAENELKELEQKHSQLTE-----EKNLLQE 901
Query: 581 DLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHAL-SWLEEVEQLLRDLGILPSSPNKDQVQ 639
L+ E +L + +K L+ + H + + LEE E D G + K Q
Sbjct: 902 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE----DRGQQLQAERKKMAQ 957
Query: 640 QFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYI---TQ 696
Q E + E EA AR + Q + + + K LE+ I
Sbjct: 958 QM---------------LDLEEQLEEEEA-ARQKLQLEKVTAEAKI--KKLEDEILVMDD 999
Query: 697 ERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLA 756
+ N+ + + +R+ +L + LA++++ AK++T+ KN+ + + E + R+++ EE+
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEK-AKNLTKLKNKHESMISELEVRLKK-EEKSR 1057
Query: 757 RQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKE 816
++ E L+ + + E + + ++ +L+ L +++E ++ +A R E +K
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA---RLDDEIAQKN 1114
Query: 817 K--KKVQDLENRLTKQKEELE--------LKEQKEDV------LNNKLSDALAMVEETQK 860
KK+++LE ++ +E+L+ ++QK D+ L +L D L Q+
Sbjct: 1115 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174
Query: 861 TKATESLKAESLALKLNETL----AELETTKTKMIMVEERLILQQKMVKALQDEQESQRH 916
+A + L L+E A+++ + K E L Q + K + + +
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Query: 917 GFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKI-----EGEIATLKDNDPAPKEER 971
E+E + +++ Q +E K +K+ +++ +GE A + ND K +
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294
Query: 972 PQDPLVAPMTESS------AKDMA--YEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHS 1023
+ + + E+ AKD+A L D Q+E + V KLR+ E +S
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1354
Query: 1024 RMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEK----KDRELKALE 1079
L E+ KQ +E + + +Q LS K+K+ +S VE K R K +E
Sbjct: 1355 LQDQLDEEMEAKQNLERHISTLNIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 1080 EALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCK 1139
+ +EK EK K R + + D V ++ + ++Q+ F L K
Sbjct: 1410 NLTQQYEEKAAAYDKLEK-TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468
Query: 1140 GSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDA 1199
+ +R + K L AR+ + E L+ N ++ ++ L+ +
Sbjct: 1469 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE-LERTNKMLKAEMED-LVSS 1526
Query: 1200 KPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSL--- 1256
K D+ + L + K+ ++ + L+ +E L + + +L
Sbjct: 1527 KDDVG--KNVHELEKSKRALETQMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582
Query: 1257 ----MNIKNMSGHVSMKYLSRQ----EREKVNQLRQRDLDLVFDKITQ--LKNQLGRKEE 1306
+ ++ + L RQ E E ++ +QR L K + LK+ + +
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 1307 LLRGYEKDVEQLRRSKVSIEMYQSQVAKL---EDDIYKEAEEKALLKEALERMEHQLCQE 1363
++G E+ ++QLR+ + ++ +Q ++ D+I+ A+E ++LE QL
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL--- 1699
Query: 1364 KRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSS 1400
++ +A + D E+E L +E +S S
Sbjct: 1700 -------QEDLAAAERARKQADLEKEELAEELASSLS 1729
Score = 104 bits (259), Expect = 7e-22
Identities = 165/810 (20%), Positives = 354/810 (43%), Gaps = 126/810 (15%)
Query: 691 EEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQE 750
EE + + + ++T E ++K EL+ L +QK + +T+EKN ++E L+ E E
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKEL--EQKHS---QLTEEKNLLQEQLQAETELYAE 912
Query: 751 LEE---RLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKR 807
EE RLA +K+ LE I HE + LE E+ + Q L+ ++K++++ + E
Sbjct: 913 AEEMRVRLAAKKQELEE-ILHEM---EARLEEEEDRGQQLQ---AERKKMAQQMLDLE-- 963
Query: 808 KAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVL-----NNKLSDALAMVEETQKTK 862
E +E+E+ Q L+ L K E ++K+ ++++L NNKLS ++EE
Sbjct: 964 ---EQLEEEEAARQKLQ--LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018
Query: 863 ATESLKAESLALKLNETLAELETTKTKMIM-VEERLILQQKM---VKALQDEQESQRHGF 918
T + E A + L +L+ MI +E RL ++K ++ L+ + E F
Sbjct: 1019 TTNLAEEEEKA----KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 919 EEEIMEYKEQIKQHAQTIVSLEEKLQ--------KVTQHH------KKIEGEIATLKDN- 963
E+I + + QI + + EE+LQ ++ Q + +++EG I+ L+++
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 964 -------DPAPKEERP------------QDPLVAPMTESSAKDMAYEHLIDDLLAAQKEI 1004
+ A K++R +D L + T+ + + + A +E
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194
Query: 1005 LSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQM 1064
S + + ++R+ +A +++ + E ++ K L++N +++++ +L+ + Q
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTE-QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253
Query: 1065 SSLVEKKDRELKALEEALR---ASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEA 1121
VE K ++L+A + L+ + E+ R +LN +K K + + ++ + + +A
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELN-DKVHKLQNEVES--VTGMLNEAEGKA 1310
Query: 1122 FSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARS--PDHKDHQNES 1179
+++ S S + +E++Q + + + ++++LE+ R+ D D + E+
Sbjct: 1311 IKLAKDVASLSS-----QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365
Query: 1180 FLDLKNLRMENNVQKILLDAKPDLPTLS---------------RIEILAPQNGLCNARFG 1224
+L+ N+Q L D+K L + IE L Q A +
Sbjct: 1366 KQNLERHISTLNIQ--LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 1225 SAMEKSGKM-----DVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKV 1279
+ ++ D+ L+ +L ++ K + ++S KY ++R +
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 1280 ----NQLRQRDLDLVFDKITQLKNQLGRKEELLRG-----------YEKDVEQLRRSK-- 1322
+ + L ++ + K +L R ++L+ K+V +L +SK
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543
Query: 1323 --VSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKA 1380
+E ++Q+ +LED++ + K L+ ++ ++ Q E+ + Q + R+
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQNEEKRRQL 1601
Query: 1381 SLKMDQEREMLRKETSSKSSQSLLHSKPSG 1410
++ + L E ++ + K G
Sbjct: 1602 QRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Score = 89.0 bits (219), Expect = 3e-17
Identities = 141/709 (19%), Positives = 291/709 (41%), Gaps = 116/709 (16%)
Query: 242 DYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQS 301
D E+E+K NL+ ++ L+ ++S+ S++ ++ + + L+E QKEI++
Sbjct: 1360 DEEMEAKQ------NLERHISTLNIQLSD---SKKKLQDFASTVEALEEGKKRFQKEIEN 1410
Query: 302 LKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDE 361
L Q Y K L +T + E+ L + +N ++ +VS+L+K K
Sbjct: 1411 LTQQYEEKAAAYDK-LEKTKNRLQQELDDLVVDLDNQRQ-------LVSNLEK----KQR 1458
Query: 362 QVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQ 421
+ QL E ++ S+ D+ + EA ++E K R L EA E +
Sbjct: 1459 KFDQLLAEEKNISSKYADERDRAEA-----EAREKETKALSLARALEEALEAK------- 1506
Query: 422 IQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESV- 480
+++E+ K L+AE+ + + + + + E K + L+ QL+E+ +
Sbjct: 1507 -EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1565
Query: 481 ------IKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINF 534
+++N++ GQ E RD D+Q EK Q+ +
Sbjct: 1566 EDAKLRLEVNMQALKGQFE-----------------RDLQARDEQNEEKRRQLQRQLHEY 1608
Query: 535 QQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQV 594
+ + +K+ L+ + +++ +++ L DS +K + ++ L+
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSA------------IKGREEAIKQLRK 1656
Query: 595 SPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAA 654
LQ + D R E + RD + N+ + + + AA
Sbjct: 1657 ------LQAQMKDFQREL-----EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 655 GASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQE 714
R+ E A A S + ++ + LE I Q +E LEEE+ M+
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ----LEEELEEEQGNMEA 1761
Query: 715 LESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELE---ERLARQKEVLESSIAHE-- 769
+ + + TQ+ ++ L E++ Q+ E ++L RQ + L S + HE
Sbjct: 1762 MSDRV--------RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL-HEME 1812
Query: 770 ---KRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENR 826
K K K + + + K+ LE + Q+ A EK+ A ++++++ KK++++ +
Sbjct: 1813 GAVKSKFKSTIAALEAKIAQLEEQVEQE--------AREKQAATKSLKQKDKKLKEILLQ 1864
Query: 827 LTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETT 886
+ +++ E +++ + N ++ +EE ++ ES + + KL L E T
Sbjct: 1865 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE----ESQRINANRRKLQRELD--EAT 1918
Query: 887 KTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQT 935
++ M E L+ K+ + + R ++E + ++ T
Sbjct: 1919 ESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDT 1967
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 142 bits (359), Expect = 2e-33
Identities = 234/1100 (21%), Positives = 480/1100 (43%), Gaps = 188/1100 (17%)
Query: 226 KDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNE------- 278
K E+ +L + +RL + E + + ++ +L +++ E +RQ
Sbjct: 924 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983
Query: 279 ----KEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNE 334
K++ + V+D+ + KE + L+ +IS L ++ E+ +T LKN+
Sbjct: 984 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE-----EEKAKNLTKLKNK 1038
Query: 335 GENL-----------KRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQ 383
E++ ++ + L+ D EQ+ L+ +++ LK Q K+ +
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 384 LEA---------------------LGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQI 422
L+A L S L+E+L E A R E Q+++L
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG------ 1152
Query: 423 QDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIK 482
+++E +L L + T+Q + ++ +E + +++ L E++R Q+QEM + +
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA- 1211
Query: 483 INLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQ 542
+E QLE F+ RAK DK ++Q +EK +N + + L
Sbjct: 1212 --VEELTEQLEQFK---------RAKANLDK---NKQTLEK------ENADLAGELRVLG 1251
Query: 543 KETQLSNSKQEETTENIEKLRTSL-DSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGL 601
+ Q K+++ +++L++ D +A +++ H L+ EV+ + + ++
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-LNEAEGKA 1310
Query: 602 QKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREG 661
K+ DV + S L++ ++LL +++ +Q S + S ++
Sbjct: 1311 IKLAKDVASLS-SQLQDTQELL-----------QEETRQKLNVSTKLRQLEEERNSLQDQ 1358
Query: 662 EAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQ-ELESLLA 720
E EA+ E + K L+++ + E LEE +KR Q E+E+L
Sbjct: 1359 LDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS-----TVEALEEGKKRFQKEIENLTQ 1413
Query: 721 Q--QKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALE 778
Q +K A + + KNR+++ L+ +L L Q++++ + LE
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELD-------DLVVDLDNQRQLVSN------------LE 1454
Query: 779 SEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKV---QDLENRLTKQKEELE 835
++RK L L ++K IS R EA EKE K + + LE L + KEELE
Sbjct: 1455 KKQRKFDQL---LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-EAKEELE 1510
Query: 836 -----LKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKM 890
LK + ED++++K D V E +K+K + E + +L E EL+ T+
Sbjct: 1511 RTNKMLKAEMEDLVSSK-DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 891 IMVEERL-ILQQKMVKALQ--DEQ-ESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQK- 945
+ +E + L+ + + LQ DEQ E +R + ++ EY+ +++ +E+ Q+
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE---------DERKQRA 1620
Query: 946 -VTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEI 1004
KK+EG++ L+ A + ++ + + + A+ ++ ++D A++ EI
Sbjct: 1621 LAAAAKKKLEGDLKDLELQ--ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 1005 LSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQ- 1063
+ + K K L E M+L++++ ++ K+ + KE++A+
Sbjct: 1679 FATAKENEKKAKSL---------------EADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 1064 -MSSL-----VEKKDRELKA----LEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQ 1113
SSL ++ + R L+A LEE L +E+ ++ +++ +K ++ + +
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEEL--EEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 1114 IEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQ-KKALSELRARIKELEKARSPDH 1172
E + S+++Q + +R K E ++ + K ++ L A+I +LE+ +
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 1173 KDHQNESFLDLKNLRM-ENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSG 1231
++ Q + K+L+ + +++ILL + + + + A + G+A K
Sbjct: 1842 REKQAAT----KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK--------GNARVKQL 1889
Query: 1232 KMDVAEALELSEKLYLDMSK 1251
K + EA E S+++ + K
Sbjct: 1890 KRQLEEAEEESQRINANRRK 1909
Score = 140 bits (353), Expect = 9e-33
Identities = 222/1127 (19%), Positives = 487/1127 (43%), Gaps = 149/1127 (13%)
Query: 349 VSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELR 408
V+ ++++ AK++++Q+ KE +++ K+ + + L ++L+E+L+ E
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET--ELYA 911
Query: 409 EAQEKELKLC--KTQIQDMEKEMK-KLRAELRKSCTEQSVISRTLREKSKVEEKL-QEDS 464
EA+E ++L K +++++ EM+ +L E + Q+ + ++ +EE+L +E++
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 465 RRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKI 524
R+ LQL+ K+ E + +LE +++ K +++ + ++++ +
Sbjct: 972 ARQKLQLE---------KVTAEAKIKKLE---DEILVMDDQNNKLSKERKLLEERISDLT 1019
Query: 525 TQVTEDN------INFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCC 578
T + E+ + K ++ E ++ K+E++ + +EKL+ L+ +
Sbjct: 1020 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA 1079
Query: 579 SHDLKKEVDLLQHLQVSPPVSGLQKVV------LDVLRHALSWLEEVEQLLRDLGILPSS 632
DL+ ++ L+ +Q++ LQ + + +AL + E+E + DL
Sbjct: 1080 --DLQAQIAELK-MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL------ 1130
Query: 633 PNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREG------ 686
Q S +A A K G E EA + E ++ + Q +
Sbjct: 1131 ----QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1186
Query: 687 GKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKE------- 739
KAL+E + +E ++ + ++EL L Q K+A A ++ KE
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 740 --ALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEI 797
L + + V+ +++L Q + L+S + +R A+ L + K+Q+ +T
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER-ARAELNDKVHKLQNEVESVTGMLNE 1305
Query: 798 SESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELK----EQKEDVLNNKLSDALA 853
+E A + K ++ + + Q+L T+QK + K E++ + L ++L + +
Sbjct: 1306 AEGK-AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1364
Query: 854 MVEETQKTKATESLKAESLALKLNE---TLAELETTKTKMIMVEERLILQQKMVKALQDE 910
+ ++ +T +++ KL + T+ LE K + E L Q + A D+
Sbjct: 1365 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1424
Query: 911 QESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQ---HHKKIEGEIATLKDNDPAP 967
E ++ ++E+ + + Q + +LE+K +K Q K I + A + D A
Sbjct: 1425 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA--DERDRAE 1482
Query: 968 KEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSD 1027
E R E K ++ +++ L A++E+ +++ +DL + +
Sbjct: 1483 AEAR----------EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG- 1531
Query: 1028 LRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQE 1087
K ELE++ ++ Q +E+ E++ E L+ +AL+ E
Sbjct: 1532 -------KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584
Query: 1088 KH---RLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQE--QQSFSDLGVRCKGS- 1141
+ R + N EK ++ +++ +T ++ E +++++ + DL ++ +
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 1142 -RHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLK-NLRMENNVQKILLDA 1199
EE I++ +K ++++ +ELE AR+ ++E F K N + +++ L+
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARA-----SRDEIFATAKENEKKAKSLEADLMQL 1699
Query: 1200 KPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNI 1259
+ DL +A E++ K E EL+E+L +S
Sbjct: 1700 QEDL---------------------AAAERARKQADLEKEELAEELASSLSGRNALQDEK 1738
Query: 1260 KNMSGHV------------SMKYLSRQEREKVNQLRQRDLDLVFDKITQLKN-----QLG 1302
+ + + +M+ +S + R+ Q Q +L ++ T KN QL
Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 1303 RKEELLRGYEKDVEQLRRSKV--SIEMYQSQVAKLEDDIYKEAEEKAL----LKEALERM 1356
R+ + LR ++E +SK +I ++++A+LE+ + +EA EK LK+ +++
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1858
Query: 1357 EHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
+ L Q + + Q K K + ++ Q + L E + + SQ +
Sbjct: 1859 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL--EEAEEESQRI 1903
Score = 105 bits (261), Expect = 4e-22
Identities = 193/937 (20%), Positives = 385/937 (41%), Gaps = 112/937 (11%)
Query: 521 IEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSH 580
++ + QVT Q K+ LQK T+ K E + +E+ + L + +
Sbjct: 848 VKPLLQVTRQEEEMQAKEDELQK-TKERQQKAENELKELEQKHSQLTE-----EKNLLQE 901
Query: 581 DLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHAL-SWLEEVEQLLRDLGILPSSPNKDQVQ 639
L+ E +L + +K L+ + H + + LEE E D G + K Q
Sbjct: 902 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE----DRGQQLQAERKKMAQ 957
Query: 640 QFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYI---TQ 696
Q E + E EA AR + Q + + + K LE+ I
Sbjct: 958 QM---------------LDLEEQLEEEEA-ARQKLQLEKVTAEAKI--KKLEDEILVMDD 999
Query: 697 ERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLA 756
+ N+ + + +R+ +L + LA++++ AK++T+ KN+ + + E + R+++ EE+
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEK-AKNLTKLKNKHESMISELEVRLKK-EEKSR 1057
Query: 757 RQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKE 816
++ E L+ + + E + + ++ +L+ L +++E ++ +A R E +K
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA---RLDDEIAQKN 1114
Query: 817 K--KKVQDLENRLTKQKEELE--------LKEQKEDV------LNNKLSDALAMVEETQK 860
KK+++LE ++ +E+L+ ++QK D+ L +L D L Q+
Sbjct: 1115 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174
Query: 861 TKATESLKAESLALKLNETL----AELETTKTKMIMVEERLILQQKMVKALQDEQESQRH 916
+A + L L+E A+++ + K E L Q + K + + +
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Query: 917 GFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKI-----EGEIATLKDNDPAPKEER 971
E+E + +++ Q +E K +K+ +++ +GE A + ND K +
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294
Query: 972 PQDPLVAPMTESS------AKDMA--YEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHS 1023
+ + + E+ AKD+A L D Q+E + V KLR+ E +S
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1354
Query: 1024 RMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEK----KDRELKALE 1079
L E+ KQ +E + + +Q LS K+K+ +S VE K R K +E
Sbjct: 1355 LQDQLDEEMEAKQNLERHISTLNIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 1080 EALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCK 1139
+ +EK EK K R + + D V ++ + ++Q+ F L K
Sbjct: 1410 NLTQQYEEKAAAYDKLEK-TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468
Query: 1140 GSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDA 1199
+ +R + K L AR+ + E L+ N ++ ++ L+ +
Sbjct: 1469 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE-LERTNKMLKAEMED-LVSS 1526
Query: 1200 KPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSL--- 1256
K D+ + L + K+ ++ + L+ +E L + + +L
Sbjct: 1527 KDDVG--KNVHELEKSKRALETQMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582
Query: 1257 ----MNIKNMSGHVSMKYLSRQ----EREKVNQLRQRDLDLVFDKITQ--LKNQLGRKEE 1306
+ ++ + L RQ E E ++ +QR L K + LK+ + +
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 1307 LLRGYEKDVEQLRRSKVSIEMYQSQVAKL---EDDIYKEAEEKALLKEALERMEHQLCQE 1363
++G E+ ++QLR+ + ++ +Q ++ D+I+ A+E ++LE QL
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL--- 1699
Query: 1364 KRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSS 1400
++ +A + D E+E L +E +S S
Sbjct: 1700 -------QEDLAAAERARKQADLEKEELAEELASSLS 1729
Score = 104 bits (259), Expect = 7e-22
Identities = 165/810 (20%), Positives = 354/810 (43%), Gaps = 126/810 (15%)
Query: 691 EEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQE 750
EE + + + ++T E ++K EL+ L +QK + +T+EKN ++E L+ E E
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKEL--EQKHS---QLTEEKNLLQEQLQAETELYAE 912
Query: 751 LEE---RLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKR 807
EE RLA +K+ LE I HE + LE E+ + Q L+ ++K++++ + E
Sbjct: 913 AEEMRVRLAAKKQELEE-ILHEM---EARLEEEEDRGQQLQ---AERKKMAQQMLDLE-- 963
Query: 808 KAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVL-----NNKLSDALAMVEETQKTK 862
E +E+E+ Q L+ L K E ++K+ ++++L NNKLS ++EE
Sbjct: 964 ---EQLEEEEAARQKLQ--LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018
Query: 863 ATESLKAESLALKLNETLAELETTKTKMIM-VEERLILQQKM---VKALQDEQESQRHGF 918
T + E A + L +L+ MI +E RL ++K ++ L+ + E F
Sbjct: 1019 TTNLAEEEEKA----KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 919 EEEIMEYKEQIKQHAQTIVSLEEKLQ--------KVTQHH------KKIEGEIATLKDN- 963
E+I + + QI + + EE+LQ ++ Q + +++EG I+ L+++
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 964 -------DPAPKEERP------------QDPLVAPMTESSAKDMAYEHLIDDLLAAQKEI 1004
+ A K++R +D L + T+ + + + A +E
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194
Query: 1005 LSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQM 1064
S + + ++R+ +A +++ + E ++ K L++N +++++ +L+ + Q
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTE-QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253
Query: 1065 SSLVEKKDRELKALEEALR---ASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEA 1121
VE K ++L+A + L+ + E+ R +LN +K K + + ++ + + +A
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELN-DKVHKLQNEVES--VTGMLNEAEGKA 1310
Query: 1122 FSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARS--PDHKDHQNES 1179
+++ S S + +E++Q + + + ++++LE+ R+ D D + E+
Sbjct: 1311 IKLAKDVASLSS-----QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365
Query: 1180 FLDLKNLRMENNVQKILLDAKPDLPTLS---------------RIEILAPQNGLCNARFG 1224
+L+ N+Q L D+K L + IE L Q A +
Sbjct: 1366 KQNLERHISTLNIQ--LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 1225 SAMEKSGKM-----DVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKV 1279
+ ++ D+ L+ +L ++ K + ++S KY ++R +
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 1280 ----NQLRQRDLDLVFDKITQLKNQLGRKEELLRG-----------YEKDVEQLRRSK-- 1322
+ + L ++ + K +L R ++L+ K+V +L +SK
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543
Query: 1323 --VSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKA 1380
+E ++Q+ +LED++ + K L+ ++ ++ Q E+ + Q + R+
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQNEEKRRQL 1601
Query: 1381 SLKMDQEREMLRKETSSKSSQSLLHSKPSG 1410
++ + L E ++ + K G
Sbjct: 1602 QRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Score = 99.8 bits (247), Expect = 2e-20
Identities = 162/787 (20%), Positives = 328/787 (41%), Gaps = 99/787 (12%)
Query: 263 ELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKV---LCQ 319
EL + T T ++ + Q+ VL + +D +E +S ++Q+ +++ +++ L +
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALD---EETRSHEAQVQEMRQKHAQAVEELTE 1217
Query: 320 TLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKD 379
L + +L + L+++NA +G + L + + + ++L+ +V L+S+ D
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277
Query: 380 KDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKS 439
+ L + L+ E+ E L EA+ K +KL K + + +++ + L++
Sbjct: 1278 GERARAELNDKVHKLQNEV--ESVTGMLNEAEGKAIKLAK-DVASLSSQLQDTQELLQEE 1334
Query: 440 CTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQV 499
++ +S LR+ + LQ+ ++ Q + S + I L + +L+ F S V
Sbjct: 1335 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394
Query: 500 IKATYGRAKPFRDKPVTDQQLIEKITQVTEDNI----NFQQKKWTLQKETQ---LSNSKQ 552
G+ + Q+ IE +TQ E+ ++ K LQ+E + Q
Sbjct: 1395 EALEEGKKR--------FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 553 EETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHA 612
+ N+EK + D A K + +++ + + L + + + L A
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE-A 1505
Query: 613 LSWLEEVEQLLR----DLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAE---R 665
LE ++L+ DL K+ + A+ T + E E E
Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1565
Query: 666 GEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQE---LESLLAQQ 722
+A+ R E Q +A +E ++R + + L E +++ +L A
Sbjct: 1566 EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625
Query: 723 KKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEV---LESSIAHEKRKAKEALES 779
KK L + + + A++ + +++L + A+ K+ LE + A A E+
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1685
Query: 780 EKRKVQDLENHLTQQKEISESNIAYEKRKAKEA-MEKE------------KKKVQD---- 822
EK K + LE L Q +E ++A +R K+A +EKE + +QD
Sbjct: 1686 EK-KAKSLEADLMQLQE----DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1740
Query: 823 LENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAES----------- 871
LE R+ + +EELE ++ + +++++ A E+ ATE A+
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1800
Query: 872 ---LALKLNE-----------TLAELETTKTKMI-MVEERLILQQKMVKALQDEQESQRH 916
L KL+E T+A LE ++ VE+ +Q K+L+ + + +
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 917 ---GFEEE---IMEYKEQ-------IKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDN 963
E+E +YKEQ +KQ + + EE+ Q++ + +K++ E+ ++
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Query: 964 DPAPKEE 970
+ A E
Sbjct: 1921 NEAMGRE 1927
Score = 88.2 bits (217), Expect = 5e-17
Identities = 142/674 (21%), Positives = 279/674 (41%), Gaps = 123/674 (18%)
Query: 242 DYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQS 301
D E+E+K NL+ ++ L+ ++S+ S++ ++ + + L+E QKEI++
Sbjct: 1360 DEEMEAKQ------NLERHISTLNIQLSD---SKKKLQDFASTVEALEEGKKRFQKEIEN 1410
Query: 302 LKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDE 361
L Q Y K L +T + E+ L + +N ++ +VS+L+K K
Sbjct: 1411 LTQQYEEKAAAYDK-LEKTKNRLQQELDDLVVDLDNQRQ-------LVSNLEK----KQR 1458
Query: 362 QVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQ 421
+ QL E ++ S+ D+ + EA ++E K R L EA E +
Sbjct: 1459 KFDQLLAEEKNISSKYADERDRAEA-----EAREKETKALSLARALEEALEAK------- 1506
Query: 422 IQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESV- 480
+++E+ K L+AE+ + + + + + E K + L+ QL+E+ +
Sbjct: 1507 -EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1565
Query: 481 ------IKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINF 534
+++N++ GQ E RD D+Q EK Q+ +
Sbjct: 1566 EDAKLRLEVNMQALKGQFE-----------------RDLQARDEQNEEKRRQLQRQLHEY 1608
Query: 535 QQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQV 594
+ + +K+ L+ + +++ +++ L DS +K + ++ L+
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSA------------IKGREEAIKQLRK 1656
Query: 595 SPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAA 654
LQ + D R E + RD + N+ + + + AA
Sbjct: 1657 ------LQAQMKDFQREL-----EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 655 GASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQE 714
R+ E A A S + ++ + LE I Q +E LEEE+ M+
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ----LEEELEEEQGNMEA 1761
Query: 715 LESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELE---ERLARQKEVLESSIAHE-- 769
+ + + TQ+ ++ L E++ Q+ E ++L RQ + L S + HE
Sbjct: 1762 MSDRV--------RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL-HEME 1812
Query: 770 ---KRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDL--- 823
K K K + + + K+ LE + Q+ A EK+ A ++++++ KK++++
Sbjct: 1813 GAVKSKFKSTIAALEAKIAQLEEQVEQE--------AREKQAATKSLKQKDKKLKEILLQ 1864
Query: 824 ---ENRLTKQ-KEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESL--ALKLN 877
E ++ +Q KE+ E + L +L +A EE+Q+ A L A + N
Sbjct: 1865 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEA---EEESQRINANRRKLQRELDEATESN 1921
Query: 878 ETLA-ELETTKTKM 890
E + E+ K+K+
Sbjct: 1922 EAMGREVNALKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 142 bits (359), Expect = 2e-33
Identities = 234/1100 (21%), Positives = 480/1100 (43%), Gaps = 188/1100 (17%)
Query: 226 KDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNE------- 278
K E+ +L + +RL + E + + ++ +L +++ E +RQ
Sbjct: 917 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976
Query: 279 ----KEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNE 334
K++ + V+D+ + KE + L+ +IS L ++ E+ +T LKN+
Sbjct: 977 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE-----EEKAKNLTKLKNK 1031
Query: 335 GENL-----------KRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQ 383
E++ ++ + L+ D EQ+ L+ +++ LK Q K+ +
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 384 LEA---------------------LGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQI 422
L+A L S L+E+L E A R E Q+++L
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG------ 1145
Query: 423 QDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIK 482
+++E +L L + T+Q + ++ +E + +++ L E++R Q+QEM + +
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA- 1204
Query: 483 INLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQ 542
+E QLE F+ RAK DK ++Q +EK +N + + L
Sbjct: 1205 --VEELTEQLEQFK---------RAKANLDK---NKQTLEK------ENADLAGELRVLG 1244
Query: 543 KETQLSNSKQEETTENIEKLRTSL-DSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGL 601
+ Q K+++ +++L++ D +A +++ H L+ EV+ + + ++
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-LNEAEGKA 1303
Query: 602 QKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREG 661
K+ DV + S L++ ++LL +++ +Q S + S ++
Sbjct: 1304 IKLAKDVASLS-SQLQDTQELL-----------QEETRQKLNVSTKLRQLEEERNSLQDQ 1351
Query: 662 EAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQ-ELESLLA 720
E EA+ E + K L+++ + E LEE +KR Q E+E+L
Sbjct: 1352 LDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS-----TVEALEEGKKRFQKEIENLTQ 1406
Query: 721 Q--QKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALE 778
Q +K A + + KNR+++ L+ +L L Q++++ + LE
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELD-------DLVVDLDNQRQLVSN------------LE 1447
Query: 779 SEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKV---QDLENRLTKQKEELE 835
++RK L L ++K IS R EA EKE K + + LE L + KEELE
Sbjct: 1448 KKQRKFDQL---LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL-EAKEELE 1503
Query: 836 -----LKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKM 890
LK + ED++++K D V E +K+K + E + +L E EL+ T+
Sbjct: 1504 RTNKMLKAEMEDLVSSK-DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 891 IMVEERL-ILQQKMVKALQ--DEQ-ESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQK- 945
+ +E + L+ + + LQ DEQ E +R + ++ EY+ +++ +E+ Q+
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE---------DERKQRA 1613
Query: 946 -VTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEI 1004
KK+EG++ L+ A + ++ + + + A+ ++ ++D A++ EI
Sbjct: 1614 LAAAAKKKLEGDLKDLELQ--ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 1005 LSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQ- 1063
+ + K K L E M+L++++ ++ K+ + KE++A+
Sbjct: 1672 FATAKENEKKAKSL---------------EADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 1064 -MSSL-----VEKKDRELKA----LEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQ 1113
SSL ++ + R L+A LEE L +E+ ++ +++ +K ++ + +
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEEL--EEEQGNMEAMSDRVRKATQQAEQLSNELA 1774
Query: 1114 IEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQ-KKALSELRARIKELEKARSPDH 1172
E + S+++Q + +R K E ++ + K ++ L A+I +LE+ +
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 1173 KDHQNESFLDLKNLRM-ENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSG 1231
++ Q + K+L+ + +++ILL + + + + A + G+A K
Sbjct: 1835 REKQAAT----KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK--------GNARVKQL 1882
Query: 1232 KMDVAEALELSEKLYLDMSK 1251
K + EA E S+++ + K
Sbjct: 1883 KRQLEEAEEESQRINANRRK 1902
Score = 140 bits (353), Expect = 9e-33
Identities = 222/1127 (19%), Positives = 487/1127 (43%), Gaps = 149/1127 (13%)
Query: 349 VSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELR 408
V+ ++++ AK++++Q+ KE +++ K+ + + L ++L+E+L+ E
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET--ELYA 904
Query: 409 EAQEKELKLC--KTQIQDMEKEMK-KLRAELRKSCTEQSVISRTLREKSKVEEKL-QEDS 464
EA+E ++L K +++++ EM+ +L E + Q+ + ++ +EE+L +E++
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 465 RRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKI 524
R+ LQL+ K+ E + +LE +++ K +++ + ++++ +
Sbjct: 965 ARQKLQLE---------KVTAEAKIKKLE---DEILVMDDQNNKLSKERKLLEERISDLT 1012
Query: 525 TQVTEDN------INFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCC 578
T + E+ + K ++ E ++ K+E++ + +EKL+ L+ +
Sbjct: 1013 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA 1072
Query: 579 SHDLKKEVDLLQHLQVSPPVSGLQKVV------LDVLRHALSWLEEVEQLLRDLGILPSS 632
DL+ ++ L+ +Q++ LQ + + +AL + E+E + DL
Sbjct: 1073 --DLQAQIAELK-MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL------ 1123
Query: 633 PNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREG------ 686
Q S +A A K G E EA + E ++ + Q +
Sbjct: 1124 ----QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1179
Query: 687 GKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKE------- 739
KAL+E + +E ++ + ++EL L Q K+A A ++ KE
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 740 --ALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEI 797
L + + V+ +++L Q + L+S + +R A+ L + K+Q+ +T
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER-ARAELNDKVHKLQNEVESVTGMLNE 1298
Query: 798 SESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELK----EQKEDVLNNKLSDALA 853
+E A + K ++ + + Q+L T+QK + K E++ + L ++L + +
Sbjct: 1299 AEGK-AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1357
Query: 854 MVEETQKTKATESLKAESLALKLNE---TLAELETTKTKMIMVEERLILQQKMVKALQDE 910
+ ++ +T +++ KL + T+ LE K + E L Q + A D+
Sbjct: 1358 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1417
Query: 911 QESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQ---HHKKIEGEIATLKDNDPAP 967
E ++ ++E+ + + Q + +LE+K +K Q K I + A + D A
Sbjct: 1418 LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA--DERDRAE 1475
Query: 968 KEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSD 1027
E R E K ++ +++ L A++E+ +++ +DL + +
Sbjct: 1476 AEAR----------EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG- 1524
Query: 1028 LRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQE 1087
K ELE++ ++ Q +E+ E++ E L+ +AL+ E
Sbjct: 1525 -------KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1577
Query: 1088 KH---RLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQE--QQSFSDLGVRCKGS- 1141
+ R + N EK ++ +++ +T ++ E +++++ + DL ++ +
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 1142 -RHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLK-NLRMENNVQKILLDA 1199
EE I++ +K ++++ +ELE AR+ ++E F K N + +++ L+
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARA-----SRDEIFATAKENEKKAKSLEADLMQL 1692
Query: 1200 KPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNI 1259
+ DL +A E++ K E EL+E+L +S
Sbjct: 1693 QEDL---------------------AAAERARKQADLEKEELAEELASSLSGRNALQDEK 1731
Query: 1260 KNMSGHV------------SMKYLSRQEREKVNQLRQRDLDLVFDKITQLKN-----QLG 1302
+ + + +M+ +S + R+ Q Q +L ++ T KN QL
Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 1303 RKEELLRGYEKDVEQLRRSKV--SIEMYQSQVAKLEDDIYKEAEEKAL----LKEALERM 1356
R+ + LR ++E +SK +I ++++A+LE+ + +EA EK LK+ +++
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851
Query: 1357 EHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
+ L Q + + Q K K + ++ Q + L E + + SQ +
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL--EEAEEESQRI 1896
Score = 105 bits (261), Expect = 4e-22
Identities = 193/937 (20%), Positives = 385/937 (41%), Gaps = 112/937 (11%)
Query: 521 IEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSH 580
++ + QVT Q K+ LQK T+ K E + +E+ + L + +
Sbjct: 841 VKPLLQVTRQEEEMQAKEDELQK-TKERQQKAENELKELEQKHSQLTE-----EKNLLQE 894
Query: 581 DLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHAL-SWLEEVEQLLRDLGILPSSPNKDQVQ 639
L+ E +L + +K L+ + H + + LEE E D G + K Q
Sbjct: 895 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE----DRGQQLQAERKKMAQ 950
Query: 640 QFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYI---TQ 696
Q E + E EA AR + Q + + + K LE+ I
Sbjct: 951 QM---------------LDLEEQLEEEEA-ARQKLQLEKVTAEAKI--KKLEDEILVMDD 992
Query: 697 ERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLA 756
+ N+ + + +R+ +L + LA++++ AK++T+ KN+ + + E + R+++ EE+
Sbjct: 993 QNNKLSKERKLLEERISDLTTNLAEEEEK-AKNLTKLKNKHESMISELEVRLKK-EEKSR 1050
Query: 757 RQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKE 816
++ E L+ + + E + + ++ +L+ L +++E ++ +A R E +K
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA---RLDDEIAQKN 1107
Query: 817 K--KKVQDLENRLTKQKEELE--------LKEQKEDV------LNNKLSDALAMVEETQK 860
KK+++LE ++ +E+L+ ++QK D+ L +L D L Q+
Sbjct: 1108 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167
Query: 861 TKATESLKAESLALKLNETL----AELETTKTKMIMVEERLILQQKMVKALQDEQESQRH 916
+A + L L+E A+++ + K E L Q + K + + +
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Query: 917 GFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKI-----EGEIATLKDNDPAPKEER 971
E+E + +++ Q +E K +K+ +++ +GE A + ND K +
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1287
Query: 972 PQDPLVAPMTESS------AKDMA--YEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHS 1023
+ + + E+ AKD+A L D Q+E + V KLR+ E +S
Sbjct: 1288 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1347
Query: 1024 RMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEK----KDRELKALE 1079
L E+ KQ +E + + +Q LS K+K+ +S VE K R K +E
Sbjct: 1348 LQDQLDEEMEAKQNLERHISTLNIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 1080 EALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCK 1139
+ +EK EK K R + + D V ++ + ++Q+ F L K
Sbjct: 1403 NLTQQYEEKAAAYDKLEK-TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461
Query: 1140 GSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDA 1199
+ +R + K L AR+ + E L+ N ++ ++ L+ +
Sbjct: 1462 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE-LERTNKMLKAEMED-LVSS 1519
Query: 1200 KPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSL--- 1256
K D+ + L + K+ ++ + L+ +E L + + +L
Sbjct: 1520 KDDVG--KNVHELEKSKRALETQMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575
Query: 1257 ----MNIKNMSGHVSMKYLSRQ----EREKVNQLRQRDLDLVFDKITQ--LKNQLGRKEE 1306
+ ++ + L RQ E E ++ +QR L K + LK+ + +
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 1307 LLRGYEKDVEQLRRSKVSIEMYQSQVAKL---EDDIYKEAEEKALLKEALERMEHQLCQE 1363
++G E+ ++QLR+ + ++ +Q ++ D+I+ A+E ++LE QL
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL--- 1692
Query: 1364 KRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSS 1400
++ +A + D E+E L +E +S S
Sbjct: 1693 -------QEDLAAAERARKQADLEKEELAEELASSLS 1722
Score = 104 bits (259), Expect = 7e-22
Identities = 165/810 (20%), Positives = 354/810 (43%), Gaps = 126/810 (15%)
Query: 691 EEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQE 750
EE + + + ++T E ++K EL+ L +QK + +T+EKN ++E L+ E E
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKEL--EQKHS---QLTEEKNLLQEQLQAETELYAE 905
Query: 751 LEE---RLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKR 807
EE RLA +K+ LE I HE + LE E+ + Q L+ ++K++++ + E
Sbjct: 906 AEEMRVRLAAKKQELEE-ILHEM---EARLEEEEDRGQQLQ---AERKKMAQQMLDLE-- 956
Query: 808 KAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVL-----NNKLSDALAMVEETQKTK 862
E +E+E+ Q L+ L K E ++K+ ++++L NNKLS ++EE
Sbjct: 957 ---EQLEEEEAARQKLQ--LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011
Query: 863 ATESLKAESLALKLNETLAELETTKTKMIM-VEERLILQQKM---VKALQDEQESQRHGF 918
T + E A + L +L+ MI +E RL ++K ++ L+ + E F
Sbjct: 1012 TTNLAEEEEKA----KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 919 EEEIMEYKEQIKQHAQTIVSLEEKLQ--------KVTQHH------KKIEGEIATLKDN- 963
E+I + + QI + + EE+LQ ++ Q + +++EG I+ L+++
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 964 -------DPAPKEERP------------QDPLVAPMTESSAKDMAYEHLIDDLLAAQKEI 1004
+ A K++R +D L + T+ + + + A +E
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187
Query: 1005 LSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQM 1064
S + + ++R+ +A +++ + E ++ K L++N +++++ +L+ + Q
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTE-QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246
Query: 1065 SSLVEKKDRELKALEEALR---ASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEA 1121
VE K ++L+A + L+ + E+ R +LN +K K + + ++ + + +A
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELN-DKVHKLQNEVES--VTGMLNEAEGKA 1303
Query: 1122 FSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARS--PDHKDHQNES 1179
+++ S S + +E++Q + + + ++++LE+ R+ D D + E+
Sbjct: 1304 IKLAKDVASLSS-----QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358
Query: 1180 FLDLKNLRMENNVQKILLDAKPDLPTLS---------------RIEILAPQNGLCNARFG 1224
+L+ N+Q L D+K L + IE L Q A +
Sbjct: 1359 KQNLERHISTLNIQ--LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 1225 SAMEKSGKM-----DVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKV 1279
+ ++ D+ L+ +L ++ K + ++S KY ++R +
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 1280 ----NQLRQRDLDLVFDKITQLKNQLGRKEELLRG-----------YEKDVEQLRRSK-- 1322
+ + L ++ + K +L R ++L+ K+V +L +SK
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1536
Query: 1323 --VSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKA 1380
+E ++Q+ +LED++ + K L+ ++ ++ Q E+ + Q + R+
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF--ERDLQARDEQNEEKRRQL 1594
Query: 1381 SLKMDQEREMLRKETSSKSSQSLLHSKPSG 1410
++ + L E ++ + K G
Sbjct: 1595 QRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Score = 99.8 bits (247), Expect = 2e-20
Identities = 162/787 (20%), Positives = 328/787 (41%), Gaps = 99/787 (12%)
Query: 263 ELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKV---LCQ 319
EL + T T ++ + Q+ VL + +D +E +S ++Q+ +++ +++ L +
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALD---EETRSHEAQVQEMRQKHAQAVEELTE 1210
Query: 320 TLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKD 379
L + +L + L+++NA +G + L + + + ++L+ +V L+S+ D
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 380 KDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKS 439
+ L + L+ E+ E L EA+ K +KL K + + +++ + L++
Sbjct: 1271 GERARAELNDKVHKLQNEV--ESVTGMLNEAEGKAIKLAK-DVASLSSQLQDTQELLQEE 1327
Query: 440 CTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQV 499
++ +S LR+ + LQ+ ++ Q + S + I L + +L+ F S V
Sbjct: 1328 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387
Query: 500 IKATYGRAKPFRDKPVTDQQLIEKITQVTEDNI----NFQQKKWTLQKETQ---LSNSKQ 552
G+ + Q+ IE +TQ E+ ++ K LQ+E + Q
Sbjct: 1388 EALEEGKKR--------FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 553 EETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHA 612
+ N+EK + D A K + +++ + + L + + + L A
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE-A 1498
Query: 613 LSWLEEVEQLLR----DLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAE---R 665
LE ++L+ DL K+ + A+ T + E E E
Sbjct: 1499 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1558
Query: 666 GEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQE---LESLLAQQ 722
+A+ R E Q +A +E ++R + + L E +++ +L A
Sbjct: 1559 EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1618
Query: 723 KKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEV---LESSIAHEKRKAKEALES 779
KK L + + + A++ + +++L + A+ K+ LE + A A E+
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1678
Query: 780 EKRKVQDLENHLTQQKEISESNIAYEKRKAKEA-MEKE------------KKKVQD---- 822
EK K + LE L Q +E ++A +R K+A +EKE + +QD
Sbjct: 1679 EK-KAKSLEADLMQLQE----DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1733
Query: 823 LENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAES----------- 871
LE R+ + +EELE ++ + +++++ A E+ ATE A+
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1793
Query: 872 ---LALKLNE-----------TLAELETTKTKMI-MVEERLILQQKMVKALQDEQESQRH 916
L KL+E T+A LE ++ VE+ +Q K+L+ + + +
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 917 ---GFEEE---IMEYKEQ-------IKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDN 963
E+E +YKEQ +KQ + + EE+ Q++ + +K++ E+ ++
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
Query: 964 DPAPKEE 970
+ A E
Sbjct: 1914 NEAMGRE 1920
Score = 88.2 bits (217), Expect = 5e-17
Identities = 142/674 (21%), Positives = 279/674 (41%), Gaps = 123/674 (18%)
Query: 242 DYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQS 301
D E+E+K NL+ ++ L+ ++S+ S++ ++ + + L+E QKEI++
Sbjct: 1353 DEEMEAKQ------NLERHISTLNIQLSD---SKKKLQDFASTVEALEEGKKRFQKEIEN 1403
Query: 302 LKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDE 361
L Q Y K L +T + E+ L + +N ++ +VS+L+K K
Sbjct: 1404 LTQQYEEKAAAYDK-LEKTKNRLQQELDDLVVDLDNQRQ-------LVSNLEK----KQR 1451
Query: 362 QVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQ 421
+ QL E ++ S+ D+ + EA ++E K R L EA E +
Sbjct: 1452 KFDQLLAEEKNISSKYADERDRAEA-----EAREKETKALSLARALEEALEAK------- 1499
Query: 422 IQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESV- 480
+++E+ K L+AE+ + + + + + E K + L+ QL+E+ +
Sbjct: 1500 -EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1558
Query: 481 ------IKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINF 534
+++N++ GQ E RD D+Q EK Q+ +
Sbjct: 1559 EDAKLRLEVNMQALKGQFE-----------------RDLQARDEQNEEKRRQLQRQLHEY 1601
Query: 535 QQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQV 594
+ + +K+ L+ + +++ +++ L DS +K + ++ L+
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSA------------IKGREEAIKQLRK 1649
Query: 595 SPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAA 654
LQ + D R E + RD + N+ + + + AA
Sbjct: 1650 ------LQAQMKDFQREL-----EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 655 GASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQE 714
R+ E A A S + ++ + LE I Q +E LEEE+ M+
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ----LEEELEEEQGNMEA 1754
Query: 715 LESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELE---ERLARQKEVLESSIAHE-- 769
+ + + TQ+ ++ L E++ Q+ E ++L RQ + L S + HE
Sbjct: 1755 MSDRV--------RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL-HEME 1805
Query: 770 ---KRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDL--- 823
K K K + + + K+ LE + Q+ A EK+ A ++++++ KK++++
Sbjct: 1806 GAVKSKFKSTIAALEAKIAQLEEQVEQE--------AREKQAATKSLKQKDKKLKEILLQ 1857
Query: 824 ---ENRLTKQ-KEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESL--ALKLN 877
E ++ +Q KE+ E + L +L +A EE+Q+ A L A + N
Sbjct: 1858 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEA---EEESQRINANRRKLQRELDEATESN 1914
Query: 878 ETLA-ELETTKTKM 890
E + E+ K+K+
Sbjct: 1915 EAMGREVNALKSKL 1928
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 141 bits (356), Expect = 4e-33
Identities = 234/1097 (21%), Positives = 475/1097 (43%), Gaps = 136/1097 (12%)
Query: 185 PVIKQVWTNAMKLSEKSVAEGIPGAVPPAEIYVEE-----DLAQQDKDEIILLLGKEVSR 239
P+++ + ++ G+ GA+ AE +E Q+K+++ L L E
Sbjct: 887 PLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDN 946
Query: 240 LSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEI 299
L+D E L+ +V ELS+++ + + +++ + + L+++ +K+I
Sbjct: 947 LADAEERCHLLIKSKVQLEGKVKELSERLED---EEEVNADLAARRRKLEDECTELKKDI 1003
Query: 300 QSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAK 359
LK TL++ E + +N+ +NL + A V+ L K+ A
Sbjct: 1004 DDLKL---------------TLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKAL 1048
Query: 360 DEQVQQL-------KEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQE 412
E QQ ++ VS L + Q+E L CS+ +E+ + D R R+ E
Sbjct: 1049 QEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDL--ECSLEQEKKLRMDTERAKRKL-E 1105
Query: 413 KELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREK----SKVEEKLQE-DSRRK 467
+LKL + + D ++ ++L +L+K +E S +S + ++ +++++K++E +R +
Sbjct: 1106 GDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAE 1165
Query: 468 LLQLQEMGNRESVIKINLERAVG--QLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKIT 525
L+ + R + ++ +RA +LE ++ +A A + +L
Sbjct: 1166 ELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRR 1225
Query: 526 QVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKE 585
++ E + + L+++ ++ E ++++++R L+ ++ +++ DL
Sbjct: 1226 ELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEV--DDLAAN 1283
Query: 586 VDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNS 645
V+ L + S L + D L A +EE+++ L D +S + ++Q SG
Sbjct: 1284 VETLTRAKAS--AEKLCRTYEDQLSEAKIKVEELQRQLAD-----ASTQRGRLQTESGEL 1336
Query: 646 AVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQ----ERNRA 701
+ K S + RG+A A + + + K+ + Q + +
Sbjct: 1337 SRLLEEKECLIS----QLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLL 1392
Query: 702 KETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEV 761
+E EEE + EL+ LL++ +A+ ++ + + EE + ++L RL +E
Sbjct: 1393 REQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEG 1452
Query: 762 LESSIAH--EKRKAKEALESEKRKVQ-DLENHLT-----QQKEISESNIAYEKRKAKEAM 813
+E++ A KAK L++E V +LE + +K+ E+R+ +E M
Sbjct: 1453 VEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEM 1512
Query: 814 EKEKKKVQD-------------------LENRLTKQKEELELKEQKEDVLNNKLSDALAM 854
++E + Q LE T ++E L+E+ D L +++S +
Sbjct: 1513 QRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISD-LTDQVSLSGKS 1571
Query: 855 VEETQKTK-ATESLKAE-SLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQE 912
++E +KTK A E K+E AL+ E ELE TKT R+ L+ VKA D +
Sbjct: 1572 IQELEKTKKALEGEKSEIQAALEEAEGALELEETKTL------RIQLELSQVKAEVDRKL 1625
Query: 913 SQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHH-------KKIEGEIATLKDNDP 965
+++ +EE + + H + + SL+ L T+ KK+EG++ L+
Sbjct: 1626 AEK---DEECANLR---RNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLG 1679
Query: 966 APKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAA----QKEILSQQEVIMKLRKDLTEA 1021
+ + + ++ K+ + LAA Q + L ++ ++ + A
Sbjct: 1680 HATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRA 1739
Query: 1022 HSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKM----AQMSSLVEKKDRELKA 1077
+ L E++ +E + + L+ Q+ L K+K+ AQ+S VE+ +E +
Sbjct: 1740 ALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERRE 1799
Query: 1078 LEE-ALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGV 1136
EE A +A + + +KEQ DTS +E + +Q+ +L
Sbjct: 1800 AEEKAKKAITDAAMMAEELKKEQ---------DTSAHLERMKKTL------EQTVRELQA 1844
Query: 1137 RCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRM-ENNVQKI 1195
R + + + ++ KK + +L A+++ELE + K H LK +R E V+++
Sbjct: 1845 RLEEAE-QAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEA----LKGVRKHERRVKEL 1899
Query: 1196 LLDAKPDLPTLSRIEIL 1212
A+ D L+R++ L
Sbjct: 1900 AYQAEEDRKNLARMQDL 1916
Score = 125 bits (313), Expect = 4e-28
Identities = 227/1053 (21%), Positives = 424/1053 (40%), Gaps = 170/1053 (16%)
Query: 223 QQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEIS 282
++D D++ L L K E E + + + NL E+A L + V+ T ++ +E
Sbjct: 1000 KKDIDDLKLTLAKA-------EKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAH 1052
Query: 283 QKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDN 342
Q+ D+ A++ + +L L++ + C E+ + + + + L+ D
Sbjct: 1053 QQAL---GDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAK-RKLEGDL 1108
Query: 343 AITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKD-------HQLEALGSRCSVLK 395
+T V+ +D +E++++ E+S L + +D+ +++ L +R L+
Sbjct: 1109 KLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELE 1168
Query: 396 EELKQEDAHRELREAQE----KELKLCKTQIQD--------------MEKEMKKLRAELR 437
EEL+ E A R E Q +EL+ ++++ E E+ +LR EL
Sbjct: 1169 EELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELE 1228
Query: 438 KSCTEQSVISRTLREK---SKVEEKLQEDSRRKLLQLQEMGNRESVIKI-NLERAVGQLE 493
++ LR K E Q DS +++ Q E E +++ +L V L
Sbjct: 1229 EAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLT 1288
Query: 494 HFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTL-----QKE---T 545
++ K + + ++L ++ + Q + L +KE +
Sbjct: 1289 RAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLIS 1348
Query: 546 QLSNSKQEETTENIEKLRTSL-DSCQACMKISCCSHDLKKEVDLL--QHLQVSPPVSGLQ 602
QLS K +++E+LR L + +A ++ L+ + DLL QH + + + LQ
Sbjct: 1349 QLSRGK-ALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQ 1407
Query: 603 KVVLDVLRHALSW-------------------------LEEVEQLLRDLGILPSSPNKDQ 637
+++ W L+E E+ + SS K +
Sbjct: 1408 RLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAK 1467
Query: 638 VQ-QFSGNSAVFTAGKAAGASGREGEAERG-----EARARGEAQSQNQATDGREGGKALE 691
++ Q +A A+ + +R E R R E + Q + + + L
Sbjct: 1468 LRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLG 1527
Query: 692 EYITQERN------RAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQ 745
+ + R+ A ETL+ E K +QE S L Q KSI QE + K+ALE E+
Sbjct: 1528 TELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSI-QELEKTKKALEGEK 1586
Query: 746 TRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYE 805
+ +Q E +A+ ALE E+ K ++ L+Q K + +A +
Sbjct: 1587 SEIQAALE------------------EAEGALELEETKTLRIQLELSQVKAEVDRKLAEK 1628
Query: 806 KRKAKEAMEKEKKKVQDLENRLTKQ----KEELELKEQKEDVLNN-KLSDALAMVEETQK 860
+ ++ V+ L+ L + E L LK++ E LN+ +L A + T+
Sbjct: 1629 DEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEA 1688
Query: 861 TKATESLKA------------ESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQ 908
AT ++A + LA +L+E LE + + E L +A
Sbjct: 1689 QAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEEL-------RAAL 1741
Query: 909 DEQESQRHGFEEEIMEYKEQIK-QHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAP 967
++ E R E+E++E E++ H+Q L +K KK+E ++A L
Sbjct: 1742 EQGERSRRLAEQELLEATERLNLLHSQNTGLLNQK--------KKLEADLAQLSGEVEEA 1793
Query: 968 KEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQ--QEVIMKLRKDLTEAHSRM 1025
+ER + A + A MA E + +A E + + ++ + +L+ L EA
Sbjct: 1794 AQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEA--EQ 1851
Query: 1026 SDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRAS 1085
+ LRG + QK+E + V++ EL ++K A+ V K +R +K L A +A
Sbjct: 1852 AALRGGKKQVQKLEAK-----VRELEAELDAEQKKHAEALKGVRKHERRVKEL--AYQAE 1904
Query: 1086 QEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRH-- 1143
+++ L + K + K ++ + EQQ+ ++L K
Sbjct: 1905 EDRKNLARMQDLVDKLQSKVKSYKRQFE-----------EAEQQANTNLAKYRKAQHELD 1953
Query: 1144 --EEVIQRQKKALSELRARIKELEKARSPDHKD 1174
EE + ++LRAR ++ A P HK+
Sbjct: 1954 DAEERADMAETQANKLRARTRD---ALGPKHKE 1983
Score = 106 bits (265), Expect = 1e-22
Identities = 176/777 (22%), Positives = 325/777 (41%), Gaps = 113/777 (14%)
Query: 700 RAKETLEEERKRMQELESLLA------QQKKALAKSITQEKNRVKEALEEEQTRVQELEE 753
+A+E L R ++ L LA Q+ + SITQEKN + L+ EQ + + EE
Sbjct: 893 QAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEE 952
Query: 754 RLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAM 813
R H K+K LE KV++L L ++E++ +++A +RK ++
Sbjct: 953 R------------CHLLIKSKVQLEG---KVKELSERLEDEEEVN-ADLAARRRKLEDEC 996
Query: 814 EKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEE-----TQKTKATESLK 868
+ KK + DL+ L K ++E + E K L++ +A ++E T++ KA +
Sbjct: 997 TELKKDIDDLKLTLAKAEKEKQATENKV----KNLTEEMAALDESVARLTKEKKALQEAH 1052
Query: 869 AESLA-LKLNE-TLAELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYK 926
++L L+ E ++ L K ++ E L + K L+ + E + E ++ +
Sbjct: 1053 QQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQ 1112
Query: 927 EQIKQHAQTIVSLEEKLQKV------------------TQHHKKIEGEIATLKDNDPAPK 968
E + AQ LEEKL+K Q KKI+ A ++ + +
Sbjct: 1113 ESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELE 1172
Query: 969 EERPQDPLVAPMTESSAKDMAYEHLIDDL------LAAQKEILSQQEV-IMKLRKDLTEA 1021
ER V +A+++ E L + L A Q+E ++E + +LR++L EA
Sbjct: 1173 AERAARARVEKQRAEAAREL--EELSERLEEAGGASAGQREGCRKREAELGRLRRELEEA 1230
Query: 1022 HSRMSDLRGELNEKQ---KMELEQNVVLV----QQQSKELSVLKEKMAQMSSLVEKKDRE 1074
R L KQ EL + V + Q+ KE S L+ ++ +++ VE R
Sbjct: 1231 ALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRA 1290
Query: 1075 LKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDL 1134
+ E+ R ++ QL+ K + + Q D S Q + TE+ S+ +
Sbjct: 1291 KASAEKLCRTYED----QLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEE---- 1342
Query: 1135 GVRCKGSRHEEVIQRQKKALSELRARIKELEKARSP----------------DHKDHQNE 1178
C S+ ++L ELR +++E KA+S + + + E
Sbjct: 1343 -KECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAE 1401
Query: 1179 SFLDLKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAME----KSGKMD 1234
+ +L+ L + N + +K + + R E L R A E + K
Sbjct: 1402 AQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCS 1461
Query: 1235 VAEALEL-----SEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDL 1289
E +L SE + L++ + + + H+ + +ER + + QR+L+
Sbjct: 1462 SLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLER---ALEERRRQEEEMQRELEA 1518
Query: 1290 VFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIY---KEAEEK 1346
+ L +L R L G+E+ +E L K + Q +++ L D + K +E
Sbjct: 1519 AQRESRGLGTELFR---LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQEL 1575
Query: 1347 ALLKEAL--ERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQ 1401
K+AL E+ E Q E+ A+ ++ T + L++ Q + + ++ + K +
Sbjct: 1576 EKTKKALEGEKSEIQAALEE-AEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEE 1631
Score = 104 bits (260), Expect = 5e-22
Identities = 233/1168 (19%), Positives = 474/1168 (40%), Gaps = 187/1168 (16%)
Query: 289 DEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGE---NLKRDN-AI 344
+E++ A + E++ L+ ++A ++ Q L E + IT KN+ ++DN A
Sbjct: 895 EEELAALRAELRGLRGALAA-----AEAKRQELEETHVSITQEKNDLALQLQAEQDNLAD 949
Query: 345 TSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAH 404
L K + + +V++L E + + N D + L C+ LK+++ +D
Sbjct: 950 AEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDI--DDLK 1007
Query: 405 RELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDS 464
L +A EKE + + +++++ +EM L ++SV T +K+ LQE
Sbjct: 1008 LTLAKA-EKEKQATENKVKNLTEEMAAL---------DESVARLTKEKKA-----LQEAH 1052
Query: 465 RRKLLQLQEMGNRESVI---KINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLI 521
++ L LQ +R S + K+ LE+ V LE + + K R ++ +
Sbjct: 1053 QQALGDLQAEEDRVSALTKAKLRLEQQVEDLE--------CSLEQEKKLRMDTERAKRKL 1104
Query: 522 EKITQVTEDNI-NFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMK-ISCCS 579
E ++T++++ + Q K L+++ + +S+ + + +E + Q +K + +
Sbjct: 1105 EGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARA 1164
Query: 580 HDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQ 639
+L++E++ + + ++K + R LEE+ + L + G
Sbjct: 1165 EELEEELEAERAARAR-----VEKQRAEAARE----LEELSERLEEAG------------ 1203
Query: 640 QFSGNSAVFTAGKAAGASGREGEAER-----GEARARGEAQSQNQATDGREGGKALEEYI 694
G SA G+ G RE E R EA R EA EG L E +
Sbjct: 1204 ---GASA----GQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQV 1256
Query: 695 TQERNRAKETLEEERKRMQ-ELESLLAQQKKALAKSITQEK--NRVKEALEEEQTRVQEL 751
R ++ LE+E+ ++ E++ L A + + EK ++ L E + +V+EL
Sbjct: 1257 -DSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEEL 1315
Query: 752 EERLA--------------------RQKEVLESSIAHEKRKAKEALESEKRKVQDLENHL 791
+ +LA +KE L S ++ K A ++LE +R++++ E+
Sbjct: 1316 QRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEE-ESKA 1374
Query: 792 TQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDA 851
+ + ++ +E E+E + +L+ L+K E+ K + +DA
Sbjct: 1375 KSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYE------ADA 1428
Query: 852 LAMVEETQKTKATESLK---AESLALKLNETLAELETTKTKMIMVEERLILQ-QKMVKAL 907
+ EE ++ K +L+ AE N + LE K ++ E + L+ ++ A
Sbjct: 1429 IQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAA 1488
Query: 908 QDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAP 967
+ QRH E + E + Q ++ ++ +L+ + + + E+ L+
Sbjct: 1489 AALDKKQRH-LERALEERRRQEEE-------MQRELEAAQRESRGLGTELFRLRHG---- 1536
Query: 968 KEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSD 1027
E + L E+ L D + + K I ++ L + +E + + +
Sbjct: 1537 -HEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEE 1595
Query: 1028 LRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQE 1087
G L ++ L + L Q +++ L EK + ++L R +++L+ +L A
Sbjct: 1596 AEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETR 1655
Query: 1088 KHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVI 1147
L +K+ + D +Q+ A + E Q+ + L
Sbjct: 1656 ARNEALRLKKKMEGDLN----DLELQLG----HATRQATEAQAATRL------------- 1694
Query: 1148 QRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLS 1207
++A++KE + R + + L E + Q L+ + L
Sbjct: 1695 ---------MQAQLKEEQAGRDEEQR------------LAAELHEQAQALERRASLLAAE 1733
Query: 1208 RIEILAP-QNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSL-------MNI 1259
E+ A + G E+S ++ E LE +E+L L S+ G L ++
Sbjct: 1734 LEELRAALEQG----------ERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADL 1783
Query: 1260 KNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLR 1319
+SG V R+E E+ + D ++ +++ + ++ E + + E+ V +L+
Sbjct: 1784 AQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQ 1843
Query: 1320 -----RSKVSIEMYQSQVAKLEDDIYK-EAEEKALLKEALERMEHQLCQEKRINRAIRQQ 1373
+ ++ + QV KLE + + EAE A K+ E ++ E+R+ + + Q
Sbjct: 1844 ARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRV-KELAYQ 1902
Query: 1374 KVGTRKASLKMDQEREMLRKETSSKSSQ 1401
RK +M + L+ + S Q
Sbjct: 1903 AEEDRKNLARMQDLVDKLQSKVKSYKRQ 1930
Score = 92.4 bits (228), Expect = 3e-18
Identities = 187/872 (21%), Positives = 357/872 (40%), Gaps = 157/872 (18%)
Query: 664 ERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQK 723
E+ + + +A+ N A D E L + Q + KE L E + +E+ + LA ++
Sbjct: 932 EKNDLALQLQAEQDNLA-DAEERCHLLIKSKVQLEGKVKE-LSERLEDEEEVNADLAARR 989
Query: 724 KALAKSITQEKNRVKEA------LEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEAL 777
+ L T+ K + + E+E+ + + L + L+ S+A ++ K
Sbjct: 990 RKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQ 1049
Query: 778 ESEKRKVQDLEN-------------HLTQQKEISESNIAYEKR------KAKEAMEKEKK 818
E+ ++ + DL+ L QQ E E ++ EK+ +AK +E + K
Sbjct: 1050 EAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLK 1109
Query: 819 KVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNE 878
Q+ + K++LE K +K+D ++LS VE+ Q A K + L + E
Sbjct: 1110 LTQESVADAAQDKQQLEEKLKKKD---SELSQLSLRVEDEQLLGAQMQKKIKELQARAEE 1166
Query: 879 TLAELETTKTKMIMVEERLILQQKMVKALQDEQE-------SQRHGF---EEEI----ME 924
ELE + VE++ + ++ L + E QR G E E+ E
Sbjct: 1167 LEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRE 1226
Query: 925 YKEQIKQHAQTIVSLEEK--------------LQKVTQHHKKIEGEIATLKDNDPAPKEE 970
+E +H T+ +L K LQ+V Q +K + E+ D+ A E
Sbjct: 1227 LEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVET 1286
Query: 971 RPQDPLVA---------PMTESSAKDMAYEHLIDDLLAAQ----------KEILSQQE-V 1010
+ A ++E+ K + + D + +L ++E +
Sbjct: 1287 LTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECL 1346
Query: 1011 IMKLRKDLTEAHSRMSDLRGELNEKQKME---------LEQNVVLVQQQSKELSVLKEKM 1061
I +L + A + +LR +L E+ K + L + L+++Q +E + E
Sbjct: 1347 ISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEA---EAQ 1403
Query: 1062 AQMSSLVEKKDREL---------KALEEALRASQEKHRLQLNTEKEQ------------- 1099
A++ L+ K + E+ A++ + K +L L ++ +
Sbjct: 1404 AELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSL 1463
Query: 1100 ---KPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSE 1156
K R +T++ D ++++E T A ++ ++Q + + + + EE+ + + A E
Sbjct: 1464 EKAKLRLQTESEDVTLELERA-TSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRE 1522
Query: 1157 LRARIKELEKARSPDHKDHQNESFLD-LKNLRMEN-NVQKILLDAKPDLPTLSRIEILAP 1214
R EL + R H +E L+ L+ L+ EN N+Q+ + D D +LS I
Sbjct: 1523 SRGLGTELFRLR------HGHEEALEALETLKRENKNLQEEISDL-TDQVSLSGKSIQEL 1575
Query: 1215 QNGLCNARFGSAMEKSGKMDVAEALELSE-KLYLDMSKTLGSLMNIKNMSGHVSMKYLSR 1273
+ + A+E K ++ ALE +E L L+ +KTL + + + V K +
Sbjct: 1576 E------KTKKALE-GEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEK 1628
Query: 1274 QER----EKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVE--------QLRRS 1321
E + +Q L D T+ +N+ R ++ + G D+E Q +
Sbjct: 1629 DEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEA 1688
Query: 1322 KVSIEMYQSQVAKLE---DDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTR 1378
+ + + Q+Q+ + + D+ + A E +ALER L E RA +Q +R
Sbjct: 1689 QAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSR 1748
Query: 1379 KASLKMDQEREMLRKETSSKSSQSLLHSKPSG 1410
+ + E+E+L + +LLHS+ +G
Sbjct: 1749 RLA-----EQELL----EATERLNLLHSQNTG 1771
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 140 bits (354), Expect = 7e-33
Identities = 276/1254 (22%), Positives = 501/1254 (39%), Gaps = 228/1254 (18%)
Query: 254 IANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGY 313
+A +++V L Q+V + S + EK S E++ + ++ Q L+ Q A G
Sbjct: 78 LALKRDDVTLLRQEVQDLQASLKEEKWYS-------EELKKELEKYQGLQQQ-EAKPDGL 129
Query: 314 SKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHL 373
+++ ++E+ SL+ + E + +N M KD+ +++ QL E++ +
Sbjct: 130 -------VTDSSAELQSLEQQLEEAQTENFNIKQM-----KDLF--EQKAAQLATEIADI 175
Query: 374 KSQNKDKDHQLEALGSRCSVLKEELKQE-----DAHREL--------------------- 407
KS+ ++ EA + + L EEL +E D EL
Sbjct: 176 KSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQT 235
Query: 408 --------REAQEKELK-LCK---TQIQDMEKEMKKLRAELRKSCTEQSVISRTLRE-KS 454
RE + ++LK CK +Q E + +LR+EL K E +V + L++ KS
Sbjct: 236 LMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKS 295
Query: 455 KVEEKLQED---------SRRKLLQLQEMGNRESVIKINLERAVGQLE------------ 493
V E Q++ + +L+E N ESV K N++ + Q +
Sbjct: 296 SVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSA 355
Query: 494 --------HFR-SQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKE 544
H S+ +AT + + Q L + Q+ + +Q LQ E
Sbjct: 356 SETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSE 415
Query: 545 TQLSNSKQEETTENIEKLRTSLDS----------------CQACMKISCCSHDLKKEV-- 586
+SK ET + + L +K+S LK++V
Sbjct: 416 INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475
Query: 587 -DLLQH-----LQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQ 640
LQH Q LQ+ LR A + ++EQ+LR +G +KDQ Q
Sbjct: 476 STELQHQLDKTKQQHQEQQALQQSTTAKLREAQN---DLEQVLRQIG------DKDQKIQ 526
Query: 641 FSGNSAVFTAGKAAGASGREGEAERGEAR---ARGEAQSQNQATDGREGGKALEEYITQE 697
N S E E E A+ GE NQ +E L+E +TQ
Sbjct: 527 ---NLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQL---QEKNHTLQEQVTQL 580
Query: 698 RNRAKETLEEERKRMQELESLLAQQKKAL------AKSITQEKNRVKEALEEEQTRVQEL 751
+ K E ++ + L + +QK L S+ N + L E + +V +L
Sbjct: 581 TEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQL 640
Query: 752 EERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKE 811
+ ++ + E+L S+ A AK A ++ + D + Q K+ + I + +
Sbjct: 641 DIQIKAKTELLLSAEA-----AKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA 695
Query: 812 AMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLS--DALAMVEETQKTKATESLKA 869
++ +++ LE+ L + KE+ EQK + L ++ +A ++ + K +A + L+
Sbjct: 696 KLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ 755
Query: 870 E-----SLALKLNETLAELETTKTKMIMVEERLILQQK-------MVKALQDEQESQ--R 915
+ L L+ E +LE K I+ RL LQ+K K + E+E Q +
Sbjct: 756 QRQLNTDLELRATELSKQLEMEKE--IVSSTRLDLQKKSEALESIKQKLTKQEEEKQILK 813
Query: 916 HGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDP 975
FE E K Q ++ I + +LQKV + + E++T+KD K + D
Sbjct: 814 QDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKD-----KLSKVSDS 868
Query: 976 LVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIM--------KLRKDLTEAHSRMSD 1027
L +E ++ + I DL KE+ Q +V M +L+K L +
Sbjct: 869 LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQ 928
Query: 1028 LRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQE 1087
L+ ELN Q+ +L Q ++Q KE L+ + ++ E+K ++++AL+ L+ +
Sbjct: 929 LKLELNSMQE-QLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIA-V 986
Query: 1088 KHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVI 1147
+ +L + +Q+ + Q + + + E + + + Q++F L G E +
Sbjct: 987 LQKTELENKLQQQLTQAAQ--ELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA 1044
Query: 1148 QRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLS 1207
RQ +K +E+ S +D + N N K++ + K TL
Sbjct: 1045 TRQD---------LKSVEEKLSLAQEDL-------ISNRNQIGNQNKLIQELKTAKATLE 1088
Query: 1208 RIEILAPQ--NGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGH 1265
+ Q C A D+ + L EK ++ L + IK
Sbjct: 1089 QDSAKKEQQLQERCKA----------LQDIQKEKSLKEKELVNEKSKLAEIEEIK----- 1133
Query: 1266 VSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSI 1325
RQE+E + +L + + I ++ N K+ L++ + + K ++
Sbjct: 1134 ------CRQEKE-ITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAV 1186
Query: 1326 EMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRK 1379
E + L+D + KE EE L KE +E+ E +++ I++++VG +K
Sbjct: 1187 EQEKRNQQILKDQVKKEEEE--LKKEFIEK-------EAKLHSEIKEKEVGMKK 1231
Score = 140 bits (352), Expect = 1e-32
Identities = 226/1102 (20%), Positives = 471/1102 (42%), Gaps = 149/1102 (13%)
Query: 207 PGAVPPAEIYVEEDLAQQDKDEIILLLGKEVSRLSDY--EIESKY--KDVIIANLQNEVA 262
PG A + E Q D + L +E +L D +++S+Y + I+ L++E+A
Sbjct: 218 PGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELA 277
Query: 263 ELSQKVS----ETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLK---SQISALQKGYSK 315
+ Q+V+ E + + E++QK Q L E++ K+++ L+ ++ S +K
Sbjct: 278 KGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQA 337
Query: 316 VL------CQTLSER-NSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKE 368
L CQ L R ++ TSL L T L++++ + + Q LK
Sbjct: 338 TLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQ----KLKEELSEVETKYQHLKA 393
Query: 369 EVSHLKSQNKDKDH-----QLEALGSRCSVLKEELKQEDAHRELREAQE---KELKLCKT 420
E L+ Q ++K+ Q E +L+ E + +AH L+E ++ ++L +
Sbjct: 394 EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453
Query: 421 QIQDMEKEMKKLRAELRKSCTEQSVISRTL---REKSKVEEKLQEDSRRKLLQLQEMGNR 477
Q+ D++ ++ +L +L++ T + + L +++ + ++ LQ+ + KL + Q +
Sbjct: 454 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQN--DL 511
Query: 478 ESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQK 537
E V+ R +G + + Q ++A ++K + L+EK + I +
Sbjct: 512 EQVL-----RQIGDKDQ-KIQNLEALLQKSKE-------NISLLEKEREDLYAKIQAGEG 558
Query: 538 KWTLQKETQLSN-SKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSP 596
+ + + Q N + QE+ T+ EKL+ +S + + HD +E HL+ +
Sbjct: 559 ETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENL---HDQVQEQKA--HLRAAQ 613
Query: 597 P-VSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAG 655
V L+ V ++ E+V QL D+ I K + + A TA +A
Sbjct: 614 DRVLSLETSVNELNSQLNESKEKVSQL--DIQI------KAKTELLLSAEAAKTAQRA-- 663
Query: 656 ASGREGEAERGEARARGEAQSQNQATDGREGGKAL----EEYITQERNRAKETLEEERKR 711
+ + + + + Q N+ T + A +E+ +Q + KE E+
Sbjct: 664 --DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL 721
Query: 712 MQELESLLAQQKKALAKSITQEKNRVKEALEEEQT----------RVQELEERLARQKEV 761
Q+ E L Q KK A S+ + ++ ++AL++ Q R EL ++L +KE+
Sbjct: 722 EQKTEELEGQIKKLEADSLEVKASK-EQALQDLQQQRQLNTDLELRATELSKQLEMEKEI 780
Query: 762 LESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQ 821
+ SS + +K EALES K+K+ E ++K+I + + ++ K E+ ++Q
Sbjct: 781 V-SSTRLDLQKKSEALESIKQKLTKQE----EEKQILKQDFETLSQETKIQHEELNNRIQ 835
Query: 822 DLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLA 881
L K K E E + + +KLS ++ ++ E+ K ++ L L +T
Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCK 895
Query: 882 ELETTKTKMIMVEERLILQQKMVKALQDEQESQR------HGFEEEIMEYKEQIKQHAQT 935
EL+ + +E L Q+++ K+L+ E+E+ + +E++++ + +KQ+ +
Sbjct: 896 ELK--HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953
Query: 936 IVSLEEKLQKVTQHHKKIEGEIATLKDN------DPAPKEERPQDPLVAPMTESSAK--- 986
L+ + ++ Q ++ + +I L+ E + Q L E +A+
Sbjct: 954 EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEK 1013
Query: 987 -----------DMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEK 1035
++ L D + E+L+ ++ + + + L+ A + R ++ +
Sbjct: 1014 ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ 1073
Query: 1036 QKM---------ELEQNVVLVQQQ------------------SKELSVLKEKMAQMSSLV 1068
K+ LEQ+ +QQ KEL K K+A++ +
Sbjct: 1074 NKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIK 1133
Query: 1069 EKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQ 1128
++++E+ L E L++ + + ++ K+ K Q + + + + + Q
Sbjct: 1134 CRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQ 1193
Query: 1129 QSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRM 1188
Q D + + +E I+++ K L + IKE E K +NE+ L ++ +
Sbjct: 1194 QILKDQVKKEEEELKKEFIEKEAK----LHSEIKEKEVGMK---KHEENEAKLTMQITAL 1246
Query: 1189 ENNVQKILLDAKPDLPTLSRIE 1210
N+ + + + +S +E
Sbjct: 1247 NENLGTVKKEWQSSQRRVSELE 1268
Score = 125 bits (314), Expect = 3e-28
Identities = 248/1207 (20%), Positives = 501/1207 (41%), Gaps = 212/1207 (17%)
Query: 353 QKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQE 412
+ ++ K + V L++EV L++ K++ E L + +QE L
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 413 KELKLCKTQIQDMEKE---MKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLL 469
EL+ + Q+++ + E +K+++ + + + ++ K E L+E + +K+
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 470 QLQEMGNRESVIKINLERAVGQLEHFRS-QVIKATYGRAKPFRDKPVTDQQLIEKITQVT 528
+L E N+E+ + +L+ + Q V+K + + D ++ E+ ++
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLER---ERESEKL 251
Query: 529 EDNINFQQKKWTLQKET------QLSNSKQEET--TENIEKLRTSLDSCQACMKISCCSH 580
+D Q ++ + T +L+ QE + ++KL++S++ + K +
Sbjct: 252 KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVN--ELTQKNQTLTE 309
Query: 581 DLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQ 640
+L K+ L+ + K + H + +QL L +S ++ V+
Sbjct: 310 NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDL--DCQQLQSRLSASETSLHRIHVE- 366
Query: 641 FSGNSAVFTAGKAAGASGRE-GEAERGEARARGE-AQSQNQATDGREGGKALEEYITQER 698
+ G+A E E E + E Q Q Q + + G L+ I Q
Sbjct: 367 ------LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH 420
Query: 699 NRAKET---LEEERKRMQELESLLAQQ---KKALAKSITQEKNRVKEALEEEQTRVQELE 752
++ ET L E R++E L +++ K+ + + +R++E L+E+ T EL+
Sbjct: 421 SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480
Query: 753 ERLARQK------EVLESSIAHEKRKAKEALE-------SEKRKVQDLENHLTQQKE--- 796
+L + K + L+ S + R+A+ LE + +K+Q+LE L + KE
Sbjct: 481 HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540
Query: 797 --ISESNIAYEKRKAKEA-------MEKEKKKVQDLENRLT-KQKEELELKEQKEDVLNN 846
E Y K +A E ++++ +Q+ +LT K K + E +Q ++ L++
Sbjct: 541 LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD 600
Query: 847 KLSDALAMVEETQKTKATESLKAESLALKLNETLAELE------TTKTKMIMVEE----- 895
++ + A + Q + L +LNE+ ++ KT++++ E
Sbjct: 601 QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTA 660
Query: 896 -RLILQQKM---VKALQDEQE-------------SQRHGFEEEIMEYKEQIKQHAQTIVS 938
R LQ + ALQD+Q+ ++ +E + + +K++ + +S
Sbjct: 661 QRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLS 720
Query: 939 LEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLL 998
LE+K +++ KK+E + +K A KE+ QD + + A E
Sbjct: 721 LEQKTEELEGQIKKLEADSLEVK----ASKEQALQDLQQQRQLNTDLELRATE------- 769
Query: 999 AAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGEL--NEKQKMELEQNVVLVQQQSK---- 1052
K++ ++E++ R DL + + ++ +L E++K L+Q+ + Q++K
Sbjct: 770 -LSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHE 828
Query: 1053 -------------------------ELSVLKEKMAQMS-------SLVEKKDRELKA--L 1078
ELS +K+K++++S S EK++++ KA L
Sbjct: 829 ELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAIL 888
Query: 1079 EEALRASQEKHRLQL---NTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLG 1135
+ + KH+LQ+ NT KEQK KK S +E+++ L
Sbjct: 889 DLEKTCKELKHQLQVQMENTLKEQKELKK------------------SLEKEKEASHQLK 930
Query: 1136 VRCKGSRHEEVIQRQ------KKALSELRARIKELEKARSPDHKDHQNESFLD------L 1183
+ S E++IQ Q +K +L+ I EL+ +S + K Q E+ L
Sbjct: 931 LEL-NSMQEQLIQAQNTLKQNEKEEQQLQGNINELK--QSSEQKKKQIEALQGELKIAVL 987
Query: 1184 KNLRMENNVQKILLDAKPDLPTLSRIEILAPQNG----------LCNARFGSAME----K 1229
+ +EN +Q+ L A +L + +I QN L + +G E +
Sbjct: 988 QKTELENKLQQQLTQAAQEL-AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATR 1046
Query: 1230 SGKMDVAEALELSEKLYLDMSKTLGS----LMNIKNMSGHV----SMKYLSRQEREKVNQ 1281
V E L L+++ + +G+ + +K + + K QER K Q
Sbjct: 1047 QDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQ 1106
Query: 1282 LRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQ-SQVAKLEDDIY 1340
Q++ L ++ K++L EE+ EK++ +L S ++ ++ L+D
Sbjct: 1107 DIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQ 1166
Query: 1341 KEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSS 1400
++K L+ + ++ + QEKR + ++ Q + +E E L+KE K +
Sbjct: 1167 LLIQQKLELQGKADSLKAAVEQEKRNQQILKDQ----------VKKEEEELKKEFIEKEA 1216
Query: 1401 QSLLHSK 1407
+ LHS+
Sbjct: 1217 K--LHSE 1221
Score = 109 bits (273), Expect = 2e-23
Identities = 178/915 (19%), Positives = 384/915 (41%), Gaps = 183/915 (20%)
Query: 258 QNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVL 317
QN++ ++ +++ + QN + + QK + E+I +KE + L ++I A +G + VL
Sbjct: 508 QNDLEQVLRQIGDKDQKIQNLEALLQKSK---ENISLLEKEREDLYAKIQA-GEGETAVL 563
Query: 318 CQ------TLSERNSEITS-LKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEV 370
Q TL E+ +++T LKN+ E+ K+ V + + A ++V L+ V
Sbjct: 564 NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 623
Query: 371 SHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQ-EKELKLCKTQIQDMEKEM 429
+ L SQ + ++ L + E L +A + + A + L + +QD ++E+
Sbjct: 624 NELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL 683
Query: 430 KKLRAELRKSCTEQSVISRTLREK----SKVEEKLQEDSRRKLLQLQEMGNRESVIKINL 485
K+ +L + ++ L++K S++E L+E + K L L++
Sbjct: 684 NKITTQLDQ-------VTAKLQDKQEHCSQLESHLKE-YKEKYLSLEQ----------KT 725
Query: 486 ERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKET 545
E GQ++ + ++ + + +D Q + + TE + + +K + T
Sbjct: 726 EELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEK-EIVSST 784
Query: 546 QLSNSKQEETTENIEKLRTSLDSCQACMK--ISCCSHDLKKEVDLLQHLQVSPPVSGLQK 603
+L K+ E E+I++ T + + +K S + K + + L + ++ V+ LQK
Sbjct: 785 RLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN-RIQTTVTELQK 843
Query: 604 VVLD--VLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREG 661
V ++ L LS +++ + D L +S ++ + + G +A+ K
Sbjct: 844 VKMEKEALMTELSTVKDKLSKVSDS--LKNSKSEFEKENQKGKAAILDLEKTCK------ 895
Query: 662 EAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQ 721
E + + + Q +N + +E K+LE + KE + + + ++ L Q
Sbjct: 896 -----ELKHQLQVQMENTLKEQKELKKSLE--------KEKEASHQLKLELNSMQEQLIQ 942
Query: 722 QKKALAKSITQEK------NRVKEALEEEQTRVQELEERL---ARQKEVLESSIAHEKRK 772
+ L ++ +E+ N +K++ E+++ +++ L+ L QK LE+ + + +
Sbjct: 943 AQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002
Query: 773 AKEALESEKRKVQDLENHLTQQKEI----------SESNIAYEKRKAKEAMEK------- 815
A + L +EK K+ L+N+ + +E ES + ++ K EK
Sbjct: 1003 AAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQED 1062
Query: 816 ----------EKKKVQDLENRLTKQKEELELKEQK--------EDVLNNKLSDALAMVEE 857
+ K +Q+L+ +++ KEQ+ +D+ K +V E
Sbjct: 1063 LISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNE 1122
Query: 858 TQKTKATESLKA--ESLALKLNETLA--ELETTK-------TKMIMVEERLILQQKM--V 904
K E +K E KLNE L +LE+ K K ++++++L LQ K +
Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSL 1182
Query: 905 KALQDEQESQRHGFEEEIMEYKEQIKQH-----------------------------AQT 935
KA ++++ + ++++ + +E++K+
Sbjct: 1183 KAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQ 1242
Query: 936 IVSLEEKL-----------QKVTQHHKK---IEGEIATLKDNDPAPKEERPQDPLVAPMT 981
I +L E L ++V++ K+ + GEIA L+ ++ER
Sbjct: 1243 ITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDER---------- 1292
Query: 982 ESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELE 1041
L++ L + EI Q +++L++ L + + +L E Q ++++
Sbjct: 1293 ---------RALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELG---RENQSLQIK 1340
Query: 1042 QNVVLVQQQSKELSV 1056
L ++ +++ V
Sbjct: 1341 HTQALNRKWAEDNEV 1355
Score = 103 bits (257), Expect = 1e-21
Identities = 145/703 (20%), Positives = 295/703 (41%), Gaps = 97/703 (13%)
Query: 251 DVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQ 310
D + A LQ++ SQ S ++ + QK + L+ I K+ E SL+ + S Q
Sbjct: 691 DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI--KKLEADSLEVKASKEQ 748
Query: 311 KGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEV 370
Q L ++ T L+ L + + +VSS + D+ K E ++ +K+++
Sbjct: 749 A------LQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802
Query: 371 SHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMK 430
+ + + + E L + EEL ++ T++Q ++ E +
Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQHEELNNR-------------IQTTVTELQKVKMEKE 849
Query: 431 KLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNR-ESVIKINLERAV 489
L EL + S +S +L+ EK + + +L L++ + +++ +E +
Sbjct: 850 ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL 909
Query: 490 GQLEHFRSQVIKATYGRAKPFRDKPVTDQQLI---------EKITQVTEDNIN-----FQ 535
+ + + + K + + +QLI EK Q + NIN +
Sbjct: 910 KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE 969
Query: 536 QKKWTLQ-----------KETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKK 584
QKK ++ ++T+L N Q++ T+ ++L + KIS ++ +K
Sbjct: 970 QKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE------KISVLQNNYEK 1023
Query: 585 EVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGN 644
+ + LQ G + +L + S E++ DL N++Q+ GN
Sbjct: 1024 SQETFKQLQSD--FYGRESELLATRQDLKSVEEKLSLAQEDL-----ISNRNQI----GN 1072
Query: 645 SAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKET 704
E A+A E S + +E KAL++ I +E++ ++
Sbjct: 1073 QNKLIQ-------------ELKTAKATLEQDSAKKEQQLQERCKALQD-IQKEKSLKEKE 1118
Query: 705 LEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLES 764
L E+ ++ E+E + +Q+K + K + K+ E+++E T +++ ++ L +QK L+
Sbjct: 1119 LVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEI-TNLKDAKQLLIQQKLELQG 1177
Query: 765 SIAHEKRKAKEALESEKRKVQDLENHLT-QQKEISESNIAYEKRKAKEAMEKE--KKKVQ 821
+ K A+E EKR Q L++ + +++E+ + I E + E EKE KK +
Sbjct: 1178 ----KADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHE 1233
Query: 822 DLENRLTKQ-----------KEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAE 870
+ E +LT Q K+E + +++ L + D + + T +
Sbjct: 1234 ENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERR 1293
Query: 871 SLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQES 913
+L + + E+E +TK++ ++ +L V+ L E +S
Sbjct: 1294 ALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQS 1336
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 139 bits (351), Expect = 1e-32
Identities = 241/1250 (19%), Positives = 525/1250 (42%), Gaps = 125/1250 (10%)
Query: 217 VEEDLAQQDKDEIILL-----LGKEVSRLSDYEIESKYKDVIIANLQNE--VAELSQKVS 269
VEE+ A ++E+ILL L EV RL EI+ K +++ I + + +E+ K S
Sbjct: 733 VEENEAL--REEVILLSELKSLPSEVERLRK-EIQDKSEELHIITSEKDKLFSEVVHKES 789
Query: 270 ETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEIT 329
+ + + + +E Q+ K+ ++ Y VL + N EI
Sbjct: 790 RVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN-ERMNQEIV 848
Query: 330 SLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGS 389
+L E + +S +++ K +VQ+ E+ LK Q +++D L+ +
Sbjct: 849 NLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVER 908
Query: 390 RCSVLKEELKQ-----------EDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRK 438
+++ E+L+Q +D ++L+E+ + E K+ I D + +LR
Sbjct: 909 EKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRN 968
Query: 439 SCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQ 498
+ T+ + ++ K+ E+ R L + G + + ++ VG ++ +
Sbjct: 969 ALESLKQHQETI---NTLKSKISEEVSRNLHMEENTGETKDEFQ---QKMVG-IDKKQDL 1021
Query: 499 VIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQ--KKWTLQKETQLSNSKQ--EE 554
K T +D + +QQ KI + ++ QQ + +KE ++ K+ E
Sbjct: 1022 EAKNTQTLTADVKDNEIIEQQ--RKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEM 1079
Query: 555 TTENIEKLRTSLDSCQACMKISC--CSHDLKKEVDLLQH----LQVSPPVSGLQKVVLDV 608
T EN E+LR D + +I +H +KKE +L + +V + + + +
Sbjct: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
Query: 609 LRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFS---GNSAVFTAGKAAGASGREGEAER 665
+ L+ EE+ ++ + + + + N+ + ++ + + + + E ++
Sbjct: 1140 QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSIT 1199
Query: 666 GEARARGEAQSQNQATDGREGGKALEEYIT-----QERNRAKETLEEERKRMQELESLLA 720
E + E Q + G E T +E A L+E ++ + EL ++
Sbjct: 1200 KERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVS 1259
Query: 721 QQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESE 780
++ + + EK+ K L+EE + E +E L KEV E+ +
Sbjct: 1260 EKTAQIINTQDLEKSHTK--LQEEIPVLHEEQELLPNVKEVSET-------------QET 1304
Query: 781 KRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQK 840
+++ L T + + + I E+ + E ++ +++++ L K E E K
Sbjct: 1305 MNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVK 1364
Query: 841 EDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTK---MIMVEERL 897
D L + + LA ++E+Q +K +SL + + + ++E+E K K ++ +E +
Sbjct: 1365 HDQLKEHIRETLAKIQESQ-SKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEM 1423
Query: 898 ILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEI 957
+ K ++ DE +S ++++ +E ++ + L+E ++++ H + E E+
Sbjct: 1424 LGLSKRLQESHDEMKSVAKE-KDDLQRLQEVLQSESD---QLKENIKEIVAKHLETEEEL 1479
Query: 958 ----ATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMK 1013
LK+ + E R L TE S E + D L +EI ++E
Sbjct: 1480 KVAHCCLKEQEETINELRVN--LSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFN- 1536
Query: 1014 LRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSV---LKEKMAQMSSLVEK 1070
K ++E ++++L+ + E +K ++ L +SK L + L+E ++ ++++
Sbjct: 1537 -IKQISEVQEKVNELK-QFKEHRK---AKDSALQSIESKMLELTNRLQESQEEIQIMIKE 1591
Query: 1071 KDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQ---------TCDTSVQIEPVHTEA 1121
K+ E+K ++EAL+ E+ +L+ NT++ K++Q T Q + E
Sbjct: 1592 KE-EMKRVQEALQI--ERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEH 1648
Query: 1122 FSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPD-----HKDHQ 1176
E Q + + + R +++ L E+R+ KE + RS + +D
Sbjct: 1649 LKEQFETQKLNLENIETENIRLTQILHEN---LEEMRSVTKERDDLRSVEETLKVERDQL 1705
Query: 1177 NESFLD--LKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMD 1234
E+ + ++L + ++ + + K T+ ++ + + + +E S
Sbjct: 1706 KENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDAL 1765
Query: 1235 VAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKI 1294
A+ L++ E+L + I + G VS ++ +K++ + Q+DL+ K+
Sbjct: 1766 KAQDLKIQEELRIAHMHLKEQQETIDKLRGIVS------EKTDKLSNM-QKDLENSNAKL 1818
Query: 1295 TQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYK-EAEEKALLKEAL 1353
+ +L E L +KDV + ++ +E + Q+ + K E E L ++
Sbjct: 1819 QEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLH 1878
Query: 1354 ERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
E +E +++ +++ R+ + ER+ L++ ++ L
Sbjct: 1879 ENLEEM--------KSVMKERDNLRRVEETLKLERDQLKESLQETKARDL 1920
Score = 134 bits (337), Expect = 6e-31
Identities = 274/1308 (20%), Positives = 566/1308 (43%), Gaps = 252/1308 (19%)
Query: 255 ANLQNEVAELSQKVSE-TTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGY 313
A L++E EL +K+ E TT +Q E +I Q+ ++AK+K L+ + LQ +
Sbjct: 642 AFLRSENLELKEKMKELATTYKQMENDI----QLYQSQLEAKKKMQVDLEKE---LQSAF 694
Query: 314 SKVLCQTLSERNSEITSLKNEGENLKRD---NAITSGMVSSLQKDILAKDEQVQQLKE-- 368
+++ +++TSL + + +D N G ++ LQK++ + E+ + L+E
Sbjct: 695 NEI---------TKLTSLIDG--KVPKDLLCNLELEGKITDLQKELNKEVEENEALREEV 743
Query: 369 -----------EVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELR--------- 408
EV L+ + +DK +L + S K++L E H+E R
Sbjct: 744 ILLSELKSLPSEVERLRKEIQDKSEELHIITSE----KDKLFSEVVHKESRVQGLLEEIG 799
Query: 409 -------------EAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSK 455
++ ++E + KT D E++ K + E + E +S+ ++
Sbjct: 800 KTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS 859
Query: 456 VEEKLQEDSRRKLLQLQEMGNRESVIKIN-LERAVGQLEHFRSQVIKATYGRAKPFRDKP 514
L+ + K +LQE RE ++N +E+ QLE+ S + T R K +
Sbjct: 860 SLGALKTELSYKTQELQEK-TREVQERLNEMEQLKEQLENRDSTL--QTVEREKTLITEK 916
Query: 515 VTDQQLIEKITQVTEDNINFQQKKWTLQKE-TQLSNSKQEETTENI---EKLRTSLDSCQ 570
+ QQ +E++ +T++ + +Q + +LQ E QL + + NI E+LR +L+S +
Sbjct: 917 L--QQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLK 974
Query: 571 ACMK-ISCCSHDLKKEVDLLQHLQ--VSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLG 627
+ I+ + +EV H++ Q+ ++ + + + + L D
Sbjct: 975 QHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTAD-- 1032
Query: 628 ILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGG 687
+ + + Q + FS + + E E + + + E +NQ G
Sbjct: 1033 VKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGD 1092
Query: 688 --KALEEYITQERNRA-----------------KETLEEERKRMQELESLLAQQKKALAK 728
K +E + QE+N A +E L+E+ +++QE + L ++ +++
Sbjct: 1093 ELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSE 1152
Query: 729 ------SITQEKNRVKE---ALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALES 779
I KN +K LE +T EL ++L E ++ SI E++ KE +S
Sbjct: 1153 MQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVK-SITKERKVLKELQKS 1211
Query: 780 EKRK-------VQDLENHLTQQKEISESNIAY-EKRKAKEAMEKEKKKV----------Q 821
+ + ++++E Q KE E IA+ ++ +E +++ ++ V Q
Sbjct: 1212 FETERDHLRGYIREIEATGLQTKE--ELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ 1269
Query: 822 DLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLA 881
DLE TK +EE+ + +++++L N + V ETQ+T L E K + TLA
Sbjct: 1270 DLEKSHTKLQEEIPVLHEEQELLPN-----VKEVSETQETMNELELLTEQSTTKDSTTLA 1324
Query: 882 ELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQH-AQTIVSLE 940
+E + ++ E+ Q+ +K+L E+++ + +E + +Q+K+H +T+ ++
Sbjct: 1325 RIEMERLRL---NEKFQESQEEIKSLTKERDNLK-TIKEALEVKHDQLKEHIRETLAKIQ 1380
Query: 941 EKLQKVTQ---------HHKKIEGEIATLKDNDPA------------------------- 966
E K Q KI E+ K D A
Sbjct: 1381 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV 1440
Query: 967 PKE----ERPQDPL--VAPMTESSAKDMAYEHL--IDDLLAAQKEILSQQEVIMKLRKDL 1018
KE +R Q+ L + + + K++ +HL ++L A + Q+E I +LR +L
Sbjct: 1441 AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL 1500
Query: 1019 TEAHSRMSDLRGEL---NEKQKMELEQ-----------NVVLVQQQSKELSVLKEKMAQM 1064
+E + +S ++ +L N+K + ++++ + VQ++ EL KE
Sbjct: 1501 SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK 1560
Query: 1065 SSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSS 1124
S ++ + ++ L L+ SQE+ ++ + KE++ K+ Q ++QIE
Sbjct: 1561 DSALQSIESKMLELTNRLQESQEEIQIMI---KEKEEMKRVQ---EALQIE--------R 1606
Query: 1125 SQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLK 1184
Q +++ ++ + K S+ +E + A++E + ++ E+E K+ L+L+
Sbjct: 1607 DQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHL-----KEQFETQKLNLE 1661
Query: 1185 NLRMEN-NVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEAL---- 1239
N+ EN + +IL + ++ ++++ E+ V E L
Sbjct: 1662 NIETENIRLTQILHENLEEMRSVTK-------------------ERDDLRSVEETLKVER 1702
Query: 1240 -ELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLK 1298
+L E L +++ L +K + H+ ++ +E +++LR +V +K ++
Sbjct: 1703 DQLKENLRETITRDLEKQEELKIVHMHL------KEHQETIDKLR----GIVSEKTNEIS 1752
Query: 1299 N---QLGRKEELLRGYE-KDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALE 1354
N L + L+ + K E+LR + + ++ Q + KL + ++ ++ + +++ LE
Sbjct: 1753 NMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLE 1812
Query: 1355 RMEHQLCQEKRINRAIRQQKVGTRK---ASLKMDQEREMLRKETSSKS 1399
+L ++ + +A Q + +K + K E E L+K+ +S
Sbjct: 1813 NSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS 1860
Score = 130 bits (328), Expect = 7e-30
Identities = 235/1226 (19%), Positives = 526/1226 (42%), Gaps = 174/1226 (14%)
Query: 256 NLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSK 315
+LQ E +L + +T + +E + E + Q+ I +LKS+IS + +
Sbjct: 940 SLQIERDQLKSDIHDTVNMNIDTQEQLRNAL---ESLKQHQETINTLKSKISE-EVSRNL 995
Query: 316 VLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKS 375
+ + E E K G + K+D + + +L D+ KD ++ + + ++ L
Sbjct: 996 HMEENTGETKDEFQQ-KMVGIDKKQD--LEAKNTQTLTADV--KDNEIIEQQRKIFSLIQ 1050
Query: 376 QNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAE 435
+ + LE++ + LK +LK+ + E+ ++EL+L +++K+ + + E
Sbjct: 1051 EKNELQQMLESVIAEKEQLKTDLKE---NIEMTIENQEELRLLG---DELKKQQEIVAQE 1104
Query: 436 LRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHF 495
+ ++ +SRT ++VEEKL+E S++ + Q++ N + + +++ + ++E+
Sbjct: 1105 KNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMS-EMQKKINEIENL 1163
Query: 496 RSQVIKATYGRAKPFRDKPVTDQQL-IEKITQVTEDNINFQQKKWTLQKETQLSNSKQEE 554
++++ ++K +T + + E++ + N N+++ K ++ KE ++ Q+
Sbjct: 1164 KNEL-----------KNKELTLEHMETERLELAQKLNENYEEVK-SITKERKVLKELQKS 1211
Query: 555 TTENIEKLRTSLDSCQAC-----MKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVL 609
+ LR + +A ++ LK+ + + L+ S Q + L
Sbjct: 1212 FETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDL 1271
Query: 610 RHALSWL-EEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEA 668
+ + L EE+ L + +LP+ + Q+ + T S E
Sbjct: 1272 EKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERL 1331
Query: 669 RARGEAQSQNQA----TDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKK 724
R + Q + T R+ K ++E + + ++ KE + E ++QE +S Q++
Sbjct: 1332 RLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQS--KQEQS 1389
Query: 725 ALAKSITQEKNRVKEALEEEQTRVQELE----ERLARQKEVLES-----SIAHEK---RK 772
K E ++ +E+ + + L E L K + ES S+A EK ++
Sbjct: 1390 LNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQR 1449
Query: 773 AKEALESEKRKVQDLENHLTQQKEISESNIAYEK--RKAKEAMEKEKKKVQDLENRLTKQ 830
+E L+SE ++++ KEI ++ E+ + A ++++++ + +L L+++
Sbjct: 1450 LQEVLQSESDQLKE------NIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEK 1503
Query: 831 KEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKM 890
+ E+ +++ + +N+KL + + + E ++ + + + K+NE E K K
Sbjct: 1504 ETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQIS--EVQEKVNELKQFKEHRKAKD 1561
Query: 891 IMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHH 950
++ ++ KM++ QESQ E +IM +++ + Q + +E ++ ++
Sbjct: 1562 SALQS---IESKMLELTNRLQESQE---EIQIMIKEKEEMKRVQEALQIER--DQLKENT 1613
Query: 951 KKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDD-------------- 996
K+I +A +K++ +E+ Q + + E+ K EHL +
Sbjct: 1614 KEI---VAKMKES----QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETE 1666
Query: 997 ---LLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQK------MELEQNVVLV 1047
L E L + + K R DL + R +L E + +E ++ + +V
Sbjct: 1667 NIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIV 1726
Query: 1048 QQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQ-LNTEKEQKP----- 1101
KE +E + ++ +V +K E+ +++ L S + + Q L ++E +
Sbjct: 1727 HMHLKEH---QETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHL 1783
Query: 1102 RKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSR---HEEVIQRQKKALSELR 1158
+++ +T D I T+ S+ Q+ S+ ++ K +E + KK ++E +
Sbjct: 1784 KEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQ 1843
Query: 1159 ARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGL 1218
++ E+E+ + S L+++NL + + + L + K ++ ++ L
Sbjct: 1844 KKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMK---------SVMKERDNL 1894
Query: 1219 CNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREK 1278
+E+ +L E L ++ L +K + + LS++ +E
Sbjct: 1895 RRVEETLKLERD---------QLKESLQETKARDLEIQQELK------TARMLSKEHKET 1939
Query: 1279 VNQLR-------------QRDLDLVFDKITQLKNQLGRKE-ELLRGYE---------KDV 1315
V++LR Q+DLD D++ + +L +KE +LLR E ++
Sbjct: 1940 VDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEM 1999
Query: 1316 EQLRR-------SKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINR 1368
EQL++ S S+ M Q+ K + +E A ++ L R++ L E
Sbjct: 2000 EQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKME----- 2054
Query: 1369 AIRQQKVGTRKASLKMDQEREMLRKE 1394
R Q + T + + D++ ++ E
Sbjct: 2055 --RDQFIATLREMIARDRQNHQVKPE 2078
Score = 118 bits (295), Expect = 5e-26
Identities = 247/1232 (20%), Positives = 511/1232 (41%), Gaps = 189/1232 (15%)
Query: 226 KDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKV-SETTTSRQNEKEISQK 284
KD +L + E+ LS ES + +A ++++ L + + SE+ ++N KEI K
Sbjct: 1412 KDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAK 1471
Query: 285 CQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAI 344
+E++ ++ + I+ L+ LSE+ +EI++++ + E AI
Sbjct: 1472 HLETEEELKVAHCCLKEQEETINELRVN--------LSEKETEISTIQKQLE------AI 1517
Query: 345 TSGMVSSLQKDILAKDEQ--------VQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKE 396
+ + +Q +I K+EQ VQ+ E+ K K KD L+++ S+ L
Sbjct: 1518 NDKLQNKIQ-EIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTN 1576
Query: 397 ELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKV 456
L++ ++ +++E+K + +Q ++K+ E+ E + + V
Sbjct: 1577 RLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAV 1636
Query: 457 EEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFR-SQVIKATYGRAKPFRDKPV 515
E ++ K+ +++ + + K+NLE + E+ R +Q++ + K
Sbjct: 1637 NE-----TQEKMCEIEHLKEQFETQKLNLENI--ETENIRLTQILHENLEEMRSVT-KER 1688
Query: 516 TDQQLIEKITQVTEDNINFQQKKWTL-----QKETQLSNSKQEETTENIEKLRTSLDSCQ 570
D + +E+ +V D + ++ Q+E ++ + +E E I+KLR + +
Sbjct: 1689 DDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVS--E 1746
Query: 571 ACMKISCCSHDLKKEVDLL--------QHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQL 622
+IS DL+ D L + L+++ Q+ +D LR +S E+ ++L
Sbjct: 1747 KTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVS--EKTDKL 1804
Query: 623 LRDLGILPSSPNK--DQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQA 680
L +S K +++Q+ N K + + + Q + Q
Sbjct: 1805 SNMQKDLENSNAKLQEKIQELKANEHQLITLKK--------DVNETQKKVSEMEQLKKQI 1856
Query: 681 TDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEA 740
D LE + E LEE + M+E ++L + + +++ E++++KE+
Sbjct: 1857 KDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNL-----RRVEETLKLERDQLKES 1911
Query: 741 LEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISES 800
L+E + R E+++ L K L E ++ D +K I S
Sbjct: 1912 LQETKARDLEIQQEL----------------KTARMLSKEHKETVDKLREKISEKTIQIS 1955
Query: 801 NIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQK 860
+I + K+K+ ++ KK+Q+L QK+EL+L KEDV N + +E+ +K
Sbjct: 1956 DIQKDLDKSKDELQ---KKIQEL------QKKELQLLRVKEDV--NMSHKKINEMEQLKK 2004
Query: 861 TKATESLKAES-------LALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQES 913
++L +S L KL+E+L E+ I+ +ER
Sbjct: 2005 QFEAQNLSMQSVRMDNFQLTKKLHESLEEIR------IVAKER----------------- 2041
Query: 914 QRHGFEEEIMEYKEQIK-QHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERP 972
+E+ KE +K + Q I +L E + + Q+H +++ E L D E
Sbjct: 2042 ------DELRRIKESLKMERDQFIATLREMIARDRQNH-QVKPEKRLLSDGQQHLTESLR 2094
Query: 973 Q--DPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRG 1030
+ + + S D YE L L +KEI Q+E+ M+++ +L+ + + +
Sbjct: 2095 EKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEK 2154
Query: 1031 ELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHR 1090
Q+ +E + ++ + + V K K Q S+ E+ ++E + + +
Sbjct: 2155 LFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESI---NKFEMDFIDEVEKQKELLIK 2211
Query: 1091 LQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQ 1150
+Q + P ++ + + ++ +H E + F + + ++V+ +
Sbjct: 2212 IQHLQQDCDVPSRELRDLKLNQNMD-LHIEEILKDFSESEFPSI-----KTEFQQVLSNR 2265
Query: 1151 KKALSELRARIK---ELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLS 1207
K+ L + ++EK ++ K +N+ + N NN +++ + S
Sbjct: 2266 KEMTQFLEEWLNTRFDIEKLKNGIQK--ENDRICQVNN--FFNNRIIAIMNESTEFEERS 2321
Query: 1208 RIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLY-----LDMSKTLGSLMN---I 1259
+ + K + D+ E +EKL+ L S G+ +N
Sbjct: 2322 -----------------ATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQ 2364
Query: 1260 KNMSGHVSMK---YLSRQEREKVNQLRQRDLDLVF--DKITQLKNQLGRKEELLRGYEKD 1314
N + HV+ + + + RE N L + + KI +++ +L +++ +
Sbjct: 2365 DNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAK 2424
Query: 1315 VEQ----LRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAI 1370
V + L ++K +I++ Q +VA L YKE E LK L +++ EK N
Sbjct: 2425 VHESNKCLEKTKETIQVLQDKVA-LGAKPYKEEIED--LKMKLVKID----LEKMKNAKE 2477
Query: 1371 RQQKVGTRKASLKMDQEREMLRKETSSKSSQS 1402
++++ KA+++ +E L +E +S Q+
Sbjct: 2478 FEKEISATKATVEYQKEVIRLLRENLRRSQQA 2509
Score = 113 bits (282), Expect = 1e-24
Identities = 260/1325 (19%), Positives = 535/1325 (40%), Gaps = 227/1325 (17%)
Query: 210 VPPAEIYVEEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVS 269
V + + ++++L + K + LGK ++++ + S Y D N+ + + K+S
Sbjct: 402 VTSSSLTLQQELKAKRKRRVTWCLGK-INKMKN----SNYADQF--NIPTNITTKTHKLS 454
Query: 270 ETTTSRQNEKEISQKCQVLDEDIDA----------KQKEIQSLKSQISALQKGYSKVLC- 318
R+ ++ + + V +D K ++++S++++L+ Y ++
Sbjct: 455 -INLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLD 513
Query: 319 -QTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQN 377
+ L E+ E +L A+ + ++ ++ LK V H + N
Sbjct: 514 YEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLI---HEISNLKNLVKHAEVYN 570
Query: 378 KDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKE-----LKLCKTQIQDMEKEMKKL 432
+D +++ L S+ +L+E+ Q +E ++Q+ E L I+D K+MK+
Sbjct: 571 QDLENE---LSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIED-PKQMKQT 626
Query: 433 RAELRKSCTEQSVISRTLR-EKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQ 491
+ + S LR E +++EK ++E+ ++ +++ Q
Sbjct: 627 LFDAETVALDAKRESAFLRSENLELKEK-----------MKELATTYKQMENDIQLYQSQ 675
Query: 492 LEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSK 551
LE + + F + + K+ + N+ + K LQKE
Sbjct: 676 LEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKEL------ 729
Query: 552 QEETTENIEKLRTSLDSCQACMKISCCSHDLKKEV-DLLQHLQVSPPVSGLQKVVLDVLR 610
+E EN E LR + + L+KE+ D + L + S K+ +V+
Sbjct: 730 NKEVEEN-EALREEVILLSELKSLPSEVERLRKEIQDKSEELHII--TSEKDKLFSEVVH 786
Query: 611 ---HALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGE 667
LEE+ + DL S+ K Q+F + + E +
Sbjct: 787 KESRVQGLLEEIGKTKDDLATTQSN-YKSTDQEFQNFKTLH----------MDFEQKYKM 835
Query: 668 ARARGEAQSQNQATDGREGGK------ALEEYITQERNRAKETLEEERKRMQELESLLAQ 721
E +Q +E K AL+ ++ + +E E ++R+ E+E L Q
Sbjct: 836 VLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQ 895
Query: 722 --QKKALAKSITQEK----NRVKEALEEEQTRVQE------LEERLARQKEVLESSI--- 766
+ + +++ +EK ++++ LEE +T QE L+E L +++ L+S I
Sbjct: 896 LENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDT 955
Query: 767 ----AHEKRKAKEALESEKR---------------------------------------- 782
+ + + ALES K+
Sbjct: 956 VNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGI 1015
Query: 783 -KVQDLE--NHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEEL--ELK 837
K QDLE N T ++ ++ I ++RK ++ EK ++Q + + +KE+L +LK
Sbjct: 1016 DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQ-EKNELQQMLESVIAEKEQLKTDLK 1074
Query: 838 EQKEDVLNNK-----LSDALAMVEETQKTKATESLKAESLALKLNETLAEL-ETTKTKMI 891
E E + N+ L D L +E + ++K E + + LAE+ E K K
Sbjct: 1075 ENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQ 1134
Query: 892 MVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLE----EKLQKVT 947
++E+ QQ+++ ++ E Q+ EI K ++K T+ +E E QK+
Sbjct: 1135 QLQEK---QQQLLNVQEEMSEMQKK--INEIENLKNELKNKELTLEHMETERLELAQKLN 1189
Query: 948 QHH---KKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEI 1004
+++ K I E LK+ + + ER D L + E A + + ++L A +
Sbjct: 1190 ENYEEVKSITKERKVLKELQKSFETER--DHLRGYIREIEATGLQTK---EELKIAHIHL 1244
Query: 1005 LSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQS------KELSVLK 1058
QE I +LR+ ++E +++ + + EK +L++ + ++ ++ KE+S +
Sbjct: 1245 KEHQETIDELRRSVSEKTAQI--INTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQ 1302
Query: 1059 EKMAQMSSLVE----KKDRELKALE-EALRASQEKHRLQLNTEKEQKPRKKTQTCDTSV- 1112
E M ++ L E K L +E E LR +++ Q + K R +T ++
Sbjct: 1303 ETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALE 1362
Query: 1113 ----QIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHE--------EVIQRQKKALSELRAR 1160
Q++ E + QE QS + + K +E E + + AL +
Sbjct: 1363 VKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIE 1422
Query: 1161 IKELEKARSPDHKDHQN-----------ESFLDLKNLRMENNVQKILLDAKPDLPTLSRI 1209
+ L K H + ++ + L ++ +++ N+++I+ L T +
Sbjct: 1423 MLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIV---AKHLETEEEL 1479
Query: 1210 EI----LAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGH 1265
++ L Q N + EK E + ++L K + I
Sbjct: 1480 KVAHCCLKEQEETINELRVNLSEKE-----TEISTIQKQLEAINDKLQNKIQEIYEKEEQ 1534
Query: 1266 VSMKYLSRQEREKVNQLRQ---------RDLDLVFDKITQLKNQLGRKEELLRGYEKDVE 1316
++K +S + +EKVN+L+Q L + K+ +L N+L +E ++ K+ E
Sbjct: 1535 FNIKQIS-EVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKE 1593
Query: 1317 QLRRSKVSIEMYQSQVAKLEDDI---YKEAEEKA---LLKEALERMEHQLCQEKRINRAI 1370
+++R + ++++ + Q+ + +I KE++EK L A+ + ++C+ + +
Sbjct: 1594 EMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQF 1653
Query: 1371 RQQKV 1375
QK+
Sbjct: 1654 ETQKL 1658
Score = 94.4 bits (233), Expect = 7e-19
Identities = 155/739 (20%), Positives = 318/739 (43%), Gaps = 87/739 (11%)
Query: 702 KETLE---EERKRMQELESLLAQQKK----ALAKSITQEKNRVKEA------LEEE-QTR 747
KE +E +E+ + E E+L + KK L I+ KN VK A LE E ++
Sbjct: 521 KEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSK 580
Query: 748 VQ---ELEERLARQKEVLES----SIAHEKRKAKEALESEKRKVQDLENHLTQQKEISES 800
V+ E E+++ + +E ++S +I + + E++E K+ Q L + T +
Sbjct: 581 VELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRE 640
Query: 801 N--IAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEET 858
+ + E + KE M++ + +EN + + +LE K++ + L +L A + +
Sbjct: 641 SAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKL 700
Query: 859 QKT---KATESL--------KAESLALKLNETLAELETTKTKMIMVEERLILQ---QKMV 904
K + L K L +LN+ + E E + ++I++ E L +++
Sbjct: 701 TSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLR 760
Query: 905 KALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDND 964
K +QD+ E E+ + E +V E ++Q + + K + ++AT + N
Sbjct: 761 KEIQDKSEELHIITSEKDKLFSE--------VVHKESRVQGLLEEIGKTKDDLATTQSNY 812
Query: 965 PAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSR 1024
+ +E + E K ++ + E ++Q+ I+ L K+ + S
Sbjct: 813 KSTDQEFQNFKTLHMDFEQKYK----------MVLEENERMNQE--IVNLSKEAQKFDSS 860
Query: 1025 MSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRA 1084
+ L+ EL+ K + EL++ VQ++ E+ LKE++ S ++ +RE + E L+
Sbjct: 861 LGALKTELSYKTQ-ELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQ 919
Query: 1085 SQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHE 1144
+ E+ + + + K +++ + +H + Q+ + K +H+
Sbjct: 920 TLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLK--QHQ 977
Query: 1145 EVIQRQKKALSELRARIKELEKARSPDHKDHQNESF-LDLKNLRMENNVQKILLDAKPDL 1203
E I K +SE +R +E+ + Q + +D K N Q + D K +
Sbjct: 978 ETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDN- 1036
Query: 1204 PTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKN-- 1261
EI+ Q + F EK+ + E++ ++EK L M I+N
Sbjct: 1037 ------EIIEQQRKI----FSLIQEKNELQQMLESV-IAEKEQLKTDLKENIEMTIENQE 1085
Query: 1262 ---MSGHVSMKYLSRQEREKVNQLRQR-DLDLVFDKITQLKNQLGRKEELLRGYEKDVEQ 1317
+ G K +EK + +++ +L D++ +++ +L K + L+ EK +
Sbjct: 1086 ELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQ--EKQQQL 1143
Query: 1318 LRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRIN----RAIRQQ 1373
L + EM Q ++ ++E ++ E + K L E +E +L Q+ N ++I ++
Sbjct: 1144 LNVQEEMSEM-QKKINEIE-NLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKE 1201
Query: 1374 KVGTRKASLKMDQEREMLR 1392
+ ++ + ER+ LR
Sbjct: 1202 RKVLKELQKSFETERDHLR 1220
Score = 93.6 bits (231), Expect = 1e-18
Identities = 195/1072 (18%), Positives = 442/1072 (41%), Gaps = 185/1072 (17%)
Query: 214 EIYVEEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTT 273
EIY +E+ Q + I + ++V+ L ++ K KD + ++++++ EL+ ++ E+
Sbjct: 1527 EIYEKEE---QFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQE 1583
Query: 274 S-------RQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLC-QTLSERN 325
++ K + + Q+ + + KEI + + + + K+ E+
Sbjct: 1584 EIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM 1643
Query: 326 SEITSLKN--EGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQ 383
EI LK E + L +N T + Q L E + ++S K++D
Sbjct: 1644 CEIEHLKEQFETQKLNLENIETENI------------RLTQILHENLEEMRSVTKERD-D 1690
Query: 384 LEALGSRCSVLKEELKQEDAHRELREAQ-EKELKLCKTQIQDMEKEMKKLRAELRKSCTE 442
L ++ V +++LK+ R+ + ++ELK+ +++ ++ + KLR + + E
Sbjct: 1691 LRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNE 1750
Query: 443 QSVISRTLREKSKV----EEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQ 498
S + + L + + K+QE+ R + L+E ++ + +L + +
Sbjct: 1751 ISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKD 1810
Query: 499 VIKATYGRAKPFRDKPVTDQQLI--EKITQVTEDNINFQQKKWTLQKETQLSNSKQEETT 556
+ + + ++ + QLI +K T+ ++ ++ K+ L+ SK E
Sbjct: 1811 LENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIEN 1870
Query: 557 ENI-EKLRTSLDSCQACMK----ISCCSHDLKKEVDLL---------------QHLQVSP 596
N+ +KL +L+ ++ MK + LK E D L Q L+ +
Sbjct: 1871 LNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTAR 1930
Query: 597 PVSGLQKVVLDVLRHALSWLE-EVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAG 655
+S K +D LR +S ++ + +DL K ++Q+ K
Sbjct: 1931 MLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQK-KIQELQKKELQLLRVKEDV 1989
Query: 656 ASGREGEAERGEARARGEAQS---QNQATDGREGGKALEEYITQERNRAKETLEEERKR- 711
+ E + + + EAQ+ Q+ D + K L E + + R AKE E R +
Sbjct: 1990 NMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKE 2049
Query: 712 --MQELESLLAQQKKALAKSITQEKNRVKEAL--EEEQTRVQELEERLARQKEVLESSIA 767
E + +A ++ +A+ + + ++ L + +Q + L E+ +R KE+L+
Sbjct: 2050 SLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLK---- 2105
Query: 768 HEKRKAKEALESEKRKVQDLENHLTQQKEIS-----ESNIAYEKRKAKEAMEKEKKKVQD 822
+ + E R DLE + QKE+S ++ Y + K E + ++
Sbjct: 2106 -RYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSM 2164
Query: 823 LENRLTKQKEEL-----ELKEQKEDVLNNKLSDALAMVEETQK---------------TK 862
+R+ K+ + + ++KE++ + +N D + VE+ ++ ++
Sbjct: 2165 EFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSR 2224
Query: 863 ATESLKA-ESLALKLNETLAELETTKTKMIMVEERLIL--QQKMVKALQD------EQES 913
LK +++ L + E L + ++ I E + +L +++M + L++ + E
Sbjct: 2225 ELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEK 2284
Query: 914 QRHGFEEE-----------------IM----EYKEQI----KQHAQTIVSLEEKLQKVTQ 948
++G ++E IM E++E+ K+ Q + SL+EK +K+ +
Sbjct: 2285 LKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFK 2344
Query: 949 HHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQ 1008
+++ ++ +A+ +P ++ + P S A + E
Sbjct: 2345 NYQTLKTSLASGAQVNPTTQDNKN------PHVTSRATQLTTE----------------- 2381
Query: 1009 EVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLV 1068
++ +L L+E ++ + + +++ Q KEL V + +A++ + V
Sbjct: 2382 ---------------KIRELENSLHEAKESAMHKESKIIKMQ-KELEVTNDIIAKLQAKV 2425
Query: 1069 EKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQ 1128
+ ++ L+ +E ++ Q+K L KE+ D +++ + E +++E
Sbjct: 2426 HESNKCLEKTKETIQVLQDKVALGAKPYKEEIE-------DLKMKLVKIDLEKMKNAKEF 2478
Query: 1129 QSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARS----PDHKDHQ 1176
+ + S + ++ QK+ + LR ++ ++A+ +H D Q
Sbjct: 2479 EK--------EISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQ 2522
Score = 91.3 bits (225), Expect = 6e-18
Identities = 185/909 (20%), Positives = 380/909 (41%), Gaps = 147/909 (16%)
Query: 192 TNAMKLSEKSVAEGIPGAVPPAEIYVEEDLA-----QQDKDEIILLLGKEVSRLSDYEIE 246
TN + +K + E A+ ++ ++E+L +++ E I L VS +D ++
Sbjct: 1748 TNEISNMQKDL-EHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTD-KLS 1805
Query: 247 SKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQK---EIQSLK 303
+ KD L+N A+L +K+ E + NE ++ L +D++ QK E++ LK
Sbjct: 1806 NMQKD-----LENSNAKLQEKIQEL---KANEHQLI----TLKKDVNETQKKVSEMEQLK 1853
Query: 304 SQISALQKGYSKV------LCQTLSERNSEITSLKNEGENLKRDNA---ITSGMVSSLQK 354
QI SK+ L Q L E E+ S+ E +NL+R + + +
Sbjct: 1854 KQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQ 1913
Query: 355 DILAKDEQVQQL-----------KEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDA 403
+ A+D ++QQ KE V L+ + +K Q+ + K+EL+
Sbjct: 1914 ETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQ---- 1969
Query: 404 HRELREAQEKELKLCKTQ---------IQDMEKEMKKLRAE-----------------LR 437
++++E Q+KEL+L + + I +ME+ K+ A+ L
Sbjct: 1970 -KKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLH 2028
Query: 438 KSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEM--GNRESVIKINLERAVGQLEHF 495
+S E ++++ E +++E L+ + + + L+EM +R++ +R + +
Sbjct: 2029 ESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQH 2088
Query: 496 RSQVIKATYGRAKPF--RDKPVTDQ-QLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQ 552
++ ++ R K R + D + + +++ E I FQ++ L + + S
Sbjct: 2089 LTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKE---LSMRVKANLSLP 2145
Query: 553 EETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSP--PVSGLQKVVLDVLR 610
T++IEKL T+ C M+ LK + + ++ ++ + +D +
Sbjct: 2146 YLQTKHIEKLFTANQRCS--MEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVE 2203
Query: 611 HALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARA 670
L +++ L +D + PS +D + + N + S E + + E
Sbjct: 2204 KQKELLIKIQHLQQDCDV-PSRELRDL--KLNQNMDLHIEEILKDFSESEFPSIKTEF-- 2258
Query: 671 RGEAQSQNQATDGREGGKALEEYITQ--ERNRAKETLEEERKRMQELESLLAQQKKALAK 728
Q ++ +E + LEE++ + + K +++E R+ ++ + + A+
Sbjct: 2259 ------QQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMN 2312
Query: 729 SITQEKNR---VKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQ 785
T+ + R + + E++ ++E E+L + + L++S+A + +++ V
Sbjct: 2313 ESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVT 2372
Query: 786 DLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLN 845
LT +K N +E +++ AM KE K + K ++ELE V N
Sbjct: 2373 SRATQLTTEKIRELENSLHEAKES--AMHKESK--------IIKMQKELE-------VTN 2415
Query: 846 NKLSDALAMVEET----QKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQ 901
+ ++ A V E+ +KTK T + + +AL E+E K K++ ++ +
Sbjct: 2416 DIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKID-----LE 2470
Query: 902 KMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLK 961
KM A + FE+EI K ++ + I L E L++ Q + +
Sbjct: 2471 KMKNAKE---------FEKEISATKATVEYQKEVIRLLRENLRRSQQ----AQDTSVISE 2517
Query: 962 DNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEI---LSQQEVIMKLRKDL 1018
DP P + PL ++ L + + +KEI Q E ++K + +L
Sbjct: 2518 HTDPQPSNK----PLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNEL 2573
Query: 1019 TEAHSRMSD 1027
+ +S+
Sbjct: 2574 LSNNQHLSN 2582
Score = 51.6 bits (122), Expect = 5e-06
Identities = 136/721 (18%), Positives = 290/721 (40%), Gaps = 122/721 (16%)
Query: 196 KLSEKSVA-EGIPGAVPPAEIYVEEDLAQQDKDEIILLLGKEVSRLSDYEIES------- 247
K+SEK++ I + ++ +++ + + K E+ LL KE +S +I
Sbjct: 1946 KISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQ 2005
Query: 248 -KYKDVIIANLQNEVAELSQKVSET-------TTSRQNEKEISQKCQVLDE-------DI 292
+ +++ + +++ + +L++K+ E+ R + I + ++ + ++
Sbjct: 2006 FEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREM 2065
Query: 293 DAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSL 352
A+ ++ +K + L G L ++L E+ S I L + + + L
Sbjct: 2066 IARDRQNHQVKPEKRLLSDGQQH-LTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDL 2124
Query: 353 QKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSV----LKEELKQEDAH-REL 407
+K+I + E ++K +S Q K + +L RCS+ + ++LK ++ ++
Sbjct: 2125 EKEIEFQKELSMRVKANLSLPYLQTKHIE-KLFTANQRCSMEFHRIMKKLKYVLSYVTKI 2183
Query: 408 REAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKS-------KVEEKL 460
+E Q + + + D ++ K+L +++ + V SR LR+ +EE L
Sbjct: 2184 KEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEIL 2243
Query: 461 QEDSRRKLLQL-----QEMGNRESVI---------KINLERA----------VGQLEHFR 496
++ S + + Q + NR+ + + ++E+ + Q+ +F
Sbjct: 2244 KDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFF 2303
Query: 497 SQVIKATYGRAKPFRDKPVT-DQQLIEKITQVTEDNI----NFQQKKWTLQKETQLSNSK 551
+ I A + F ++ T ++ + + + E N N+Q K +L Q++ +
Sbjct: 2304 NNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTT 2363
Query: 552 QEE------------TTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVS 599
Q+ TTE I +L SL + H K + + + L+V+ +
Sbjct: 2364 QDNKNPHVTSRATQLTTEKIRELENSLHEAK-----ESAMHKESKIIKMQKELEVTNDII 2418
Query: 600 GLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGR 659
+ + L +E Q+L+D L + P K++++ K A +
Sbjct: 2419 AKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNA--K 2476
Query: 660 EGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELE--- 716
E E E +A E Q +E + L E + + + ++ E Q
Sbjct: 2477 EFEKEISATKATVEYQ--------KEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPL 2528
Query: 717 -----SLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKR 771
S + Q KAL + E R LE+E +++++ E+L +QK L S+ H
Sbjct: 2529 TCGGGSGIVQNTKALI--LKSEHIR----LEKEISKLKQQNEQLIKQKNELLSNNQHLSN 2582
Query: 772 KAK----EALESEKRKVQDLENH---------LTQQKEISESNIAYEKRKAKEAMEKEKK 818
+ K L+ E K EN +++K+I+ S ++R ++ + KE
Sbjct: 2583 EVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQC--KERNLQDPVPKESP 2640
Query: 819 K 819
K
Sbjct: 2641 K 2641
Score = 31.6 bits (70), Expect = 5.6
Identities = 26/101 (25%), Positives = 43/101 (42%), Gaps = 12/101 (11%)
Query: 1293 KITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEA 1352
K T N++ E LL+ Y K++ L++ + + A +D + + EEK LL
Sbjct: 330 KNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLL--- 386
Query: 1353 LERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRK 1393
Q Q ++I R +SL + QE + RK
Sbjct: 387 ------QKVQNEKIENLTRML---VTSSSLTLQQELKAKRK 418
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 134 bits (337), Expect = 6e-31
Identities = 226/1055 (21%), Positives = 446/1055 (42%), Gaps = 167/1055 (15%)
Query: 223 QQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEIS 282
++D D++ L L K E E + + NL E++ L + +++ T ++ +E
Sbjct: 952 KKDIDDLELTLAK-------VEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAH 1004
Query: 283 QKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDN 342
Q Q LD D+ A++ ++ SL S L+ Q + + S + K +L+R+
Sbjct: 1005 Q--QALD-DLQAEEDKVNSLNKTKSKLE--------QQVEDLESSLEQEKKLRVDLERNK 1053
Query: 343 AITSGMVSSLQKDILAKDEQVQQL-----KEEVSHLKSQNKDKDHQ---------LEALG 388
G + Q+ IL + QQL K++ + + Q+K +D Q ++ L
Sbjct: 1054 RKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQ 1113
Query: 389 SRCSVLKEELKQEDAHR---------------ELREAQEKELKLCKTQIQ---DMEKEMK 430
+R L+EE++ E A R EL E E+ + TQI+ E E
Sbjct: 1114 ARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFL 1173
Query: 431 KLRAELRKSCTEQSVISRTLREK---------------SKVEEKLQEDSRRKLLQLQEMG 475
KLR +L ++ + + LR+K +V++KL+++ L++ ++
Sbjct: 1174 KLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLS 1233
Query: 476 NR-ESVIK--INLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNI 532
+ ESV K NLE+ LE S+ R K ++++ ++++T
Sbjct: 1234 SSMESVSKSKANLEKICRTLEDQLSEA------RGK--------NEEIQRSLSELTTQKS 1279
Query: 533 NFQQKKWTLQKE--------TQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKK 584
Q + L ++ +QLS SKQ T + E R + +A ++ +
Sbjct: 1280 RLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRH 1339
Query: 585 EVDLL--QHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFS 642
+ DLL Q+ + + LQ+ + W + E K Q+
Sbjct: 1340 DCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1399
Query: 643 GNSAVFTAGKAAGASGREGEAERGEARARGE----------AQSQNQATDGREGG--KAL 690
+ A A AS E+ + R +GE A S A D ++ K L
Sbjct: 1400 DSEEQVEAVNAKCAS-----LEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVL 1454
Query: 691 EEYITQ-ERNRAK--ETLEEERKRMQELESLLAQQKKALA---------KSITQEKNRVK 738
E+ T+ E ++A+ +L+E R EL L ++AL K++ QE +
Sbjct: 1455 AEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLT 1514
Query: 739 EALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEIS 798
E + E + ELE+ +Q E+ ++ I +A+ ALE E+ K+ ++ LTQ K
Sbjct: 1515 EQIAENGKTIHELEKS-RKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEI 1573
Query: 799 ESNIAYEKRKAKEAMEKEKKKVQDLENRL----TKQKEELELKEQKEDVLNN---KLSDA 851
+ IA + + ++ ++ V+ +++ L + E + LK++ E LN +LS A
Sbjct: 1574 DRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHA 1633
Query: 852 LAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQ--- 908
ET K + + + L L++ L E K ++ +VE R L Q V+ L+
Sbjct: 1634 NRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATL 1693
Query: 909 DEQESQRHGFEEEIMEYKEQIK-QHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDN-DPA 966
++ E R E+E+++ E+++ H Q + K KK+E ++ L+ + A
Sbjct: 1694 EQTERARKLAEQELLDSNERVQLLHTQNTSLIHTK--------KKLETDLMQLQSEVEDA 1745
Query: 967 PKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMS 1026
++ R +A++ A + + D + A+ E+ +Q+ L + +
Sbjct: 1746 SRDAR------------NAEEKAKKAITDAAMMAE-ELKKEQDTSAHLERMKKNLEQTVK 1792
Query: 1027 DLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQ 1086
DL+ L+E +++ L+ +Q+ ++E ++ +K +K L + R +
Sbjct: 1793 DLQHRLDEAEQLALKGGKKQIQKLETR---IRELEFELEGEQKKNTESVKGLRKYERRVK 1849
Query: 1087 EKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRH--- 1143
E L +E+++K + Q +Q++ + + ++Q+ + L + + ++H
Sbjct: 1850 E---LTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHL-TKFRKAQHELE 1905
Query: 1144 --EEVIQRQKKALSELRARIKELEKARSPDHKDHQ 1176
EE + +++LRA+ ++ +R H+ +
Sbjct: 1906 EAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE 1940
Score = 122 bits (307), Expect = 2e-27
Identities = 240/1163 (20%), Positives = 488/1163 (41%), Gaps = 186/1163 (15%)
Query: 254 IANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDI-DAKQKEIQSLKS--QISALQ 310
+A + + EL +K+ T Q + ++ + Q E++ DA+++ Q +K+ Q+ A
Sbjct: 864 LAKSEAKRKELEEKL---VTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKI 920
Query: 311 KGYSKVLCQTLSERNSEITS----LKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQL 366
K ++ + E N+E+T+ L++E LK+D ++ ++K+ A + +V+ L
Sbjct: 921 KEVTE-RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 979
Query: 367 KEEVSHLKSQNKDKDHQLEALGSRCSVLKEELK-QEDAHRELREAQEKELKLCKTQIQDM 425
EE+S L + +AL ++L+ +ED L + + K + Q++D+
Sbjct: 980 TEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSK----LEQQVEDL 1035
Query: 426 EKEM---KKLRAELRKSCTE--------QSVISRTLREKSKVEEKLQEDSRRKLLQLQEM 474
E + KKLR +L ++ + Q I +K +++E+L++ + QLQ
Sbjct: 1036 ESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKD-FEYCQLQSK 1094
Query: 475 GNRESVIKINLERAVGQL----EHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTED 530
E + + ++ + +L E ++ RAK T++Q + ++ E
Sbjct: 1095 VEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK-------TEKQRSDYARELEEL 1147
Query: 531 NINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDL-KKEVDLL 589
+ ++ + +L+ ++ E KLR L+ +A ++ L KK D +
Sbjct: 1148 SERLEEAGGVTSTQIELNKKREAE----FLKLRRDLE--EATLQHEAMVAALRKKHADSV 1201
Query: 590 QHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFT 649
L + LQ+V + + + E++ L S + + V + N
Sbjct: 1202 AEL--GEQIDNLQRVKQKLEKEKSEFKLEIDDL---------SSSMESVSKSKANLEKIC 1250
Query: 650 AGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEER 709
R E + EAR + E E ++L E +T +++R + E
Sbjct: 1251 ---------RTLEDQLSEARGKNE-----------EIQRSLSE-LTTQKSRLQTEAGELS 1289
Query: 710 KRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHE 769
++++E ES+++Q ++ ++ TQ+ +K LEEE L L S H+
Sbjct: 1290 RQLEEKESIVSQLSRS-KQAFTQQTEELKRQLEEENKAKNALAHAL--------QSSRHD 1340
Query: 770 KRKAKEALESEKRKVQDLENHLTQ-QKEISESNIAYE------KRKAKEAMEKEKKKVQD 822
+E E E+ +L+ L++ E+++ YE + +EA +K +++QD
Sbjct: 1341 CDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD 1400
Query: 823 LENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESL-------ALK 875
E ++ + E+ + L ++ D + VE A K + K
Sbjct: 1401 SEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTK 1460
Query: 876 LNETLAELETTKTKMIMVEERLILQQKMVKALQDEQES---QRHGFEEEIMEYKEQIKQH 932
E+ AELE + + + L + + D+ E+ + E+EI + EQI ++
Sbjct: 1461 CEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAEN 1520
Query: 933 AQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEE-----RPQDPLVAPMTESSAKD 987
+TI LE+ +++ I+ L++ + A + E R Q L +E K
Sbjct: 1521 GKTIHELEKSRKQIELEKADIQ---LALEEAEAALEHEEAKILRIQLELTQVKSEIDRKI 1577
Query: 988 MAYEHLIDDLLA-AQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNE---------KQK 1037
+ I+ L Q+ + + Q + + EA + G+LNE +Q
Sbjct: 1578 AEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQA 1637
Query: 1038 MELEQNVVLVQQQSKELSVL-------KEKMAQMSSLVEKKDRELKALEEALRASQEKHR 1090
E +++ VQ Q K+ + +E + + ++VE++ L+A E LRA+ E+
Sbjct: 1638 AETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQ-- 1695
Query: 1091 LQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFS--------SSQEQQSFSDLGVRCKGSR 1142
TE+ +K ++ + D++ +++ +HT+ S + Q S++ + +R
Sbjct: 1696 ----TERARKLAEQ-ELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDAR 1750
Query: 1143 HEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPD 1202
+ E ++ KKA+++ +EL+K + D H RM+ N+++ + D +
Sbjct: 1751 NAE--EKAKKAITDAAMMAEELKKEQ--DTSAHLE---------RMKKNLEQTVKDLQHR 1797
Query: 1203 LPTLSRIEILAPQNGLCNARFGSAMEKSGKMDV----AEALELSEKLYLDMSKTLGSLMN 1258
L ++ + K GK + EL +L + K S+
Sbjct: 1798 LDEAEQLAL-----------------KGGKKQIQKLETRIRELEFELEGEQKKNTESVKG 1840
Query: 1259 IKNMSGHV-SMKYLSRQEREKVNQLRQRDL-DLVFDKITQLKNQLGRKEEL----LRGYE 1312
++ V + Y S ++R+ N LR +DL D + K+ K Q +E L +
Sbjct: 1841 LRKYERRVKELTYQSEEDRK--NVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFR 1898
Query: 1313 KDVEQLRRSKVSIEMYQSQVAKL 1335
K +L ++ ++ +SQV KL
Sbjct: 1899 KAQHELEEAEERADIAESQVNKL 1921
Score = 106 bits (264), Expect = 2e-22
Identities = 208/1111 (18%), Positives = 465/1111 (41%), Gaps = 94/1111 (8%)
Query: 354 KDILAKDE-QVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQE 412
KD LAK E + ++L+E++ L + D Q++A +E Q + EA+
Sbjct: 861 KDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKI 920
Query: 413 KELKLCKTQIQDMEKEMKKLRAELRKSCTE-QSVISRTLREKSKVE-EKLQEDSRRKLLQ 470
KE+ +++ E+ + +L C+E + I +KVE EK +++ K L
Sbjct: 921 KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 980
Query: 471 LQEMGNRESVIKINLERAVGQLEHFRS-QVIKATYGRAKPFRDKPVTDQQLIEKITQVTE 529
+ G E++ K+ E+ Q H ++ ++A + +Q +E + E
Sbjct: 981 EELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLE 1040
Query: 530 D----NINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKE 585
++ ++ K L+ + +L+ +E+ ++E + LD C K E
Sbjct: 1041 QEKKLRVDLERNKRKLEGDLKLA----QESILDLENDKQQLDERLKKKDFEYCQLQSKVE 1096
Query: 586 VDLLQHLQVSPPVSGLQKVVLDVLRHA-----------------LSWLEEVEQLLRDLGI 628
+ LQ + LQ + ++ LEE+ + L + G
Sbjct: 1097 DEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGG 1156
Query: 629 LPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGK 688
+ S+ Q++ A F + A + A S + + + +
Sbjct: 1157 VTST----QIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQ 1212
Query: 689 ALEEYITQERNRAKETLEEERKRMQELESLLAQQKK---------ALAKSITQEKNRVKE 739
+++ + +E++ K +++ M+ + A +K + A+ +E R
Sbjct: 1213 RVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLS 1272
Query: 740 ALEEEQTRVQELEERLARQ---KEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKE 796
L +++R+Q L+RQ KE + S ++ K+ + E KR++++ EN
Sbjct: 1273 ELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE-ENKAKNALA 1331
Query: 797 ISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVE 856
+ + ++ +E E+E++ +L+ L+K E+ K + +DA+ E
Sbjct: 1332 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYE------TDAIQRTE 1385
Query: 857 ETQKTK---ATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQES 913
E ++ K A +E +N A LE TK ++ E L++ + +L +
Sbjct: 1386 ELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK 1445
Query: 914 QRHGFEEEIMEYKEQIKQ-HAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERP 972
++ F++ + E+K + ++ A+ SL+E T+ K L + +E +
Sbjct: 1446 KQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKN 1505
Query: 973 QDPLVAPMTESSAKDMAYEHLIDDLLAAQKEI-LSQQEVIMKLRK-DLTEAHSRMSDLRG 1030
+ +A +TE A++ I +L ++K+I L + ++ + L + + H LR
Sbjct: 1506 LEQEIADLTEQIAEN---GKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRI 1562
Query: 1031 ELNEKQ-KMELEQNVVLVQQQSKELSVLKEKMAQ-MSSLVEKKDRELKALEEALRASQEK 1088
+L Q K E+++ + ++ +E+ LK + + ++ D E+++ EA+R ++K
Sbjct: 1563 QLELTQVKSEIDRKIA---EKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRL-KKK 1618
Query: 1089 HRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQ 1148
LN + Q Q +T + V + ++ Q D +R + E++
Sbjct: 1619 MEGDLNEIEIQLSHANRQAAETLKHLRSVQGQL----KDTQLHLDDALRGQEDLKEQLAI 1674
Query: 1149 RQKKA------LSELRARIKELEKARSPDHKD----HQNESFLDLKNLRMENNVQKI--- 1195
+++A + ELRA +++ E+AR ++ ++ L +N + + +K+
Sbjct: 1675 VERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETD 1734
Query: 1196 LLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGS 1255
L+ + ++ SR A + + M + K + + L E++ ++ +T+
Sbjct: 1735 LMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHL-ERMKKNLEQTVKD 1793
Query: 1256 LMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDV 1315
L + + + +++K +Q ++ ++R+ + +L ++ ++ G LR YE+ V
Sbjct: 1794 LQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKG-----LRKYERRV 1848
Query: 1316 EQLRRSKVSIEMYQSQVAKLEDDIYK-EAEEKALLKEALERMEHQLCQEKRINRAIRQQK 1374
++L E + V +L+D + K + + K+ ++A E E + +A + +
Sbjct: 1849 KELTYQS---EEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELE 1905
Query: 1375 VGTRKASLKMDQEREMLRKETSSKSSQSLLH 1405
+A + Q ++ K SS+ ++H
Sbjct: 1906 EAEERADIAESQVNKLRAKTRDFTSSRMVVH 1936
Score = 94.0 bits (232), Expect = 9e-19
Identities = 177/798 (22%), Positives = 327/798 (40%), Gaps = 146/798 (18%)
Query: 720 AQQKKALAKSITQEKNRVKEALEEEQTRVQELEER---LARQKEVLESSIAHEKR----- 771
A+ +K +A ++ +E + K+ L + + + +ELEE+ L ++K L+ + E
Sbjct: 844 AETEKEMA-TMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDA 902
Query: 772 --------KAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDL 823
KAK LE+ K++++ ++EI+ + + +KRK ++ + KK + DL
Sbjct: 903 EERCDQLIKAKFQLEA---KIKEVTERAEDEEEIN-AELTAKKRKLEDECSELKKDIDDL 958
Query: 824 ENRLTKQKEELELKEQKEDVLNNKLS---DALAMVEETQKT------KATESLKAESLAL 874
E L K ++E E K L +LS + +A + +K +A + L+AE
Sbjct: 959 ELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE---- 1014
Query: 875 KLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQ 934
+ + L TK+K+ E L + K L+ + E + E ++ +E I
Sbjct: 1015 --EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEN 1072
Query: 935 TIVSLEEKLQK----VTQHHKKIEGE----------IATLKDNDPAPKEERPQDPLVAPM 980
L+E+L+K Q K+E E I L+ +EE +
Sbjct: 1073 DKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK 1132
Query: 981 TESSAKDMA--YEHLIDDL------LAAQKEILSQQEV-IMKLRKDLTEA---HSRM--- 1025
TE D A E L + L + Q E+ ++E +KLR+DL EA H M
Sbjct: 1133 TEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAA 1192
Query: 1026 -----SDLRGELNE--------KQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKD 1072
+D EL E KQK+E E++ + + +LS E +++ + +EK
Sbjct: 1193 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSE--FKLEIDDLSSSMESVSKSKANLEKIC 1250
Query: 1073 RELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFS 1132
R L+ R E+ + L+ QK R +T+ + S Q+E + S+ +Q+F+
Sbjct: 1251 RTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFT 1310
Query: 1133 DLGVRCKGSRHEEVIQRQKKALSE-LRARIKELEKARSPDHKDHQNESFLDLKNLRMENN 1191
K EE + K AL+ L++ + + R + + + E +L+ + N
Sbjct: 1311 QQTEELKRQLEEE--NKAKNALAHALQSSRHDCDLLR--EQYEEEQEGKAELQRALSKAN 1366
Query: 1192 VQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSK 1251
+ K + + R E L + K +A+ L+ SE+ ++
Sbjct: 1367 SEVAQWRTKYETDAIQRTEEL----------------EEAKKKLAQRLQDSEEQVEAVNA 1410
Query: 1252 TLGSLMNIK-NMSGHVSMKYLSRQEREKVNQL------RQRDLDLVF------------D 1292
SL K + G V + + E+ N L +QR+ D V +
Sbjct: 1411 KCASLEKTKQRLQGEVEDLMV---DVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAE 1467
Query: 1293 KITQLKNQLGRKEELLR---GYEKDVEQLRRSKVSIEMYQSQVAKLEDDI---------- 1339
LK EL + YE+ ++QL K + + ++A L + I
Sbjct: 1468 LEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHEL 1527
Query: 1340 --------YKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREML 1391
++A+ + L+EA +EH+ + RI + Q K + + D+E E L
Sbjct: 1528 EKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQL 1587
Query: 1392 RK--ETSSKSSQSLLHSK 1407
++ + + ++ QS L ++
Sbjct: 1588 KRNYQRTVETMQSALDAE 1605
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 134 bits (336), Expect = 8e-31
Identities = 263/1257 (20%), Positives = 491/1257 (39%), Gaps = 167/1257 (13%)
Query: 218 EEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSR-- 275
EE LA+Q + E L + + L ++ A + E EL Q++ E R
Sbjct: 1347 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1406
Query: 276 ------QNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEIT 329
Q ++ I ++ Q L + +A EIQ+ Q A ++ ++ EI
Sbjct: 1407 AAVDAQQQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSRLRI--------EEEIR 1455
Query: 330 SLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEA--- 386
++ + E +R G + +L+ + Q +Q +EE L+ Q +D+ +
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 387 -LGSRCSVLKEELKQED----AHRELR-EAQEKELKLCKTQIQDMEKEMKKLRAELRKSC 440
L SR E +++ A ELR +A+E E +L + +++ + L R +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 441 TEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLE-HFRSQV 499
E + EK+ E+ ++ + QL+E R + + ERA + E
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 500 IKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENI 559
+KA + + V Q+ + + +++K ++E + +E+
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQ--------AEAEKQKEEAEREARRRGKAEEQAVRQR 1687
Query: 560 EKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEV 619
E L+ Q + L E +L++ L+ Q+ +L+ EE+
Sbjct: 1688 ELAEQELEK-QRQLAEGTAQQRLAAEQELIR-LRAETEQGEQQRQLLE---------EEL 1736
Query: 620 EQLLRDLGILPSSPN--KDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQ 677
+L R+ + ++ + V A KA +E+ + R EA
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1796
Query: 678 NQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALA---------- 727
+ + +AL E ++R A+E +R E E +LA++ A+
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIGEATRLKTEAE 1853
Query: 728 ---KSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKV 784
K E R++ E+E + + LEE+ A+ K +E +A ++ + LE +K V
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1913
Query: 785 QD-LENHLTQQKEISESNIAYEKRKA-KEAMEKEKKKVQDLENRLTKQKEELELKEQKED 842
+D L ++EI ++EK A K +E E +++ + KE+ EL+ ++
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ- 1972
Query: 843 VLNNKLSDALAMVEETQKTKATE----SLKAESLALKLNE-TLAELETTKTKMIMVEERL 897
LA EE ++ +A E SL AE A + + L E+E K K VEE
Sbjct: 1973 -------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK---VEEAR 2022
Query: 898 ILQQKMVKALQDEQESQRH---GFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHK--- 951
L+++ EQES R E + + K HA + E++LQ+ Q +
Sbjct: 2023 RLRERA------EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076
Query: 952 -KIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEV 1010
++ GE + +E R Q A + ++ E L + Q
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA--ERLKQSAEEQAQARAQAQAA 2134
Query: 1011 IMKLRKDL-TEAHSRMSDLRGELNEKQ--KMELEQNVVLVQQQSKELSVLKEKMAQMSSL 1067
KLRK+ EA R + L +KQ E+E++ +Q ++ + +++++ +
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2194
Query: 1068 VEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQE 1127
+E+ D + L+E L+ +L E + R+++Q V E FS
Sbjct: 2195 LEETDHQKNLLDEELQ--------RLKAEATEAARQRSQ----------VEEELFS---- 2232
Query: 1128 QQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLR 1187
++ Q + LS+L+ARI+ +A KD+ + FL + +
Sbjct: 2233 -------------------VRVQMEELSKLKARIEAENRALILRDKDN-TQRFLQEEAEK 2272
Query: 1188 MENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALEL-SEKLY 1246
M+ V + +R+ LA ++ M K V EA L +E
Sbjct: 2273 MK-QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2331
Query: 1247 LDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQL----RQRDLDLVFD------KITQ 1296
L K L + M +E + + RQR L++ + ++ +
Sbjct: 2332 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2391
Query: 1297 LKNQLGRKEELLRGYEKDVEQ----LRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEA 1352
+ R EE + + K E+ L R++++ + + V LE + + L+EA
Sbjct: 2392 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2451
Query: 1353 LERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPS 1409
+ +E + +EK A K+ K+ ++E L +ET + QS L K S
Sbjct: 2452 IAELERE--KEKLQQEA----KLLQLKSEEMQTVQQEQLLQETQA-LQQSFLSEKDS 2501
Score = 129 bits (324), Expect = 2e-29
Identities = 242/1276 (18%), Positives = 500/1276 (39%), Gaps = 178/1276 (13%)
Query: 250 KDVIIANLQNEVAELSQK----VSETTTSRQNEKEISQKCQVLDEDID---AKQKEIQSL 302
+DV + + VA+L ++ +++T ++ +++ ++ + E D A ++ +
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1229
Query: 303 KSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQ 362
+ QI A+ S+ + + L + + + ++ GE ++ +++++ L
Sbjct: 1230 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1289
Query: 363 VQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQI 422
QL+ S K + SV++E + + EL + +K +
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSE--------SVIQEYVDLRTHYSELTTLTSQYIKFISETL 1341
Query: 423 QDMEKEMK---KLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRES 479
+ ME+E + + RAE R+ E R+ ++ + + + R+ +LQ+ E
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 480 V-----------IKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKI---T 525
V K +++ + QL I+A +A+ + ++ I +
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 526 QVTE-DNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSL-DSCQACMKISCCSHDLK 583
+ TE + + L+ + + +++ + E E+LR + D Q +
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---------RKRQ 1512
Query: 584 KEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSG 643
EV+L ++ + ++ L L EE E+ LR + QVQ
Sbjct: 1513 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV----ERARQVQ---- 1564
Query: 644 NSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQ--ERNRA 701
A+ TA ++A A + A E A+ E Q + + + E Q E RA
Sbjct: 1565 -VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1623
Query: 702 KETLEEERKRMQ-----ELESLLAQQKKALAKSITQ-EKNRVKEALEEEQTRVQELEERL 755
+E E E +R Q L L ++ A KS+ Q E + KE E E R + EE+
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 756 ARQKEVLESSIAHEKRKA------KEALESEKRKVQDLENHLTQQKEISESNIAYEKRKA 809
RQ+E+ E + +++ A + A E E +++ QQ+++ E +A +R+A
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 810 KEAMEKEKKKVQDL-------------------ENRLT--KQKEELELKEQKEDVLNNKL 848
A +K ++ +L E+R T K K+ LE + + L +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 849 SDALAMVEETQKTK-------ATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQ 901
+ A+ EE ++ + A + +AE + + + E KT+ + + +
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 902 KMVKALQDEQESQRHGFEEEIMEYKEQI-----------------------------KQH 932
+ ++ L +++ QR EE+ ++K I +Q
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 933 AQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAP-----MTESSAKD 987
+ I++L+ +K ++E E+ ++ N + Q L A E +
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983
Query: 988 MAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLV 1047
E + LAA++E Q++ + +++ +++ + R L E+ + E + + L
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAAL---EEVERLKAKVEEAR-RLRERAEQESARQLQLA 2039
Query: 1048 QQQSKELSVLKEKMAQMSSLVEKKDREL-------KALEEALRASQEKHRLQLNTEKEQK 1100
Q+ +++ +EK + V++K++EL +++ + LR E R +E +
Sbjct: 2040 QEAAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
Query: 1101 PRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRA- 1159
+ + + + Q+E S+ ++ Q+ + + R E + ++A +E A
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 1160 RIKELEKARSPDHKDHQNESF-------LDLKNLRM---ENNVQKILLDAKPDLPTLSRI 1209
R K+ A HK ++ +L LR+ E + QK LLD +
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2217
Query: 1210 EILAPQNGLCNARFG--SAMEKSGKMDVAEALELSEKLYLDMSKTLGSLM----NIKNMS 1263
E ++ + F ME+ K+ E + D T L +K ++
Sbjct: 2218 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2277
Query: 1264 GHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKV 1323
+ ++ QE ++ QL + D L Q E++L+ + V++ R K
Sbjct: 2278 EEAARLSVAAQEAARLRQLAEED----------LAQQRALAEKMLKEKMQAVQEATRLKA 2327
Query: 1324 SIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLK 1383
E+ Q Q + E+ L+E E+M QL +E + ++ R+ L+
Sbjct: 2328 EAELLQQQKELAQ-------EQARRLQEDKEQMAQQLAEE---TQGFQRTLEAERQRQLE 2377
Query: 1384 MDQEREMLRKETSSKS 1399
M E E L+ + S
Sbjct: 2378 MSAEAERLKLRVAEMS 2393
Score = 116 bits (290), Expect = 2e-25
Identities = 189/955 (19%), Positives = 410/955 (42%), Gaps = 92/955 (9%)
Query: 240 LSDYEIESKYKDVIIANLQNEVA---ELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQ 296
L++ E+E K + + Q +A EL + +ET Q + + ++ L + A
Sbjct: 1689 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747
Query: 297 KEIQSLKSQISALQKGY-----SKVLCQTLSERNSEITSLKNEGE-----NLKRDNAITS 346
++ Q L+++++ ++ SK + S SE + + E E L + A
Sbjct: 1748 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807
Query: 347 GMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSV-LKEELKQEDAHR 405
+ ++ +E + + E + ++ + L + + LKE+ + + R
Sbjct: 1808 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1867
Query: 406 ELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCT-----EQSVISRTLREKSKVEEK- 459
L E + + + + Q + ++++ A+LRK+ ++ ++ TLR++ +VEE+
Sbjct: 1868 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1927
Query: 460 --LQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTD 517
L+ + E+ I+ N E + E + + A+ R + +
Sbjct: 1928 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1987
Query: 518 QQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETT-------ENIEKLRTSLDSCQ 570
+++ + + E +Q+K L++ +L +E E+ +L+ + ++ Q
Sbjct: 1988 ERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2044
Query: 571 ACMKISCCSHDL---KKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVE-QLLRDL 626
++ +H +KE +L Q LQ V + + R A EE Q R+
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 627 GILPSSPNK-DQVQQFSGNSAVFTAGKAAGASGREGEAERGEAR---ARGEAQSQNQATD 682
+ ++++Q + A A A A EAE+ AR A A Q QA D
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Query: 683 GR-EGGKALEEYITQERNRAKETLEEERKRMQELE---SLL---AQQKKALAKSITQEKN 735
E K E +++ + ++ L R +++E + +LL Q+ KA A ++++
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224
Query: 736 RVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQ- 794
+V+E L + +++EL + AR + + I +K + L+ E K++ + +
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284
Query: 795 ---------KEISESNIAYEKRKAKEAMEKEKKKVQDL-----ENRLTKQKEELELKEQK 840
++++E ++A ++ A++ ++++ + VQ+ E L +Q++EL +EQ
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA-QEQA 2343
Query: 841 EDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQ 900
+ +K A + EETQ + T L+AE + E AE E K ++ +
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRT--LEAERQ--RQLEMSAEAERLKLRVAE------MS 2393
Query: 901 QKMVKALQDEQESQRHGFE-EEIMEYKEQIKQHAQTIV-SLEEKLQKVTQHHKKIEGEIA 958
+ +A +D Q ++ E E + E Q T+V +LE + Q+ +++ IA
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453
Query: 959 TLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDL 1018
L+ KE+ Q+ + + + + E L+ + A Q+ LS+++ +++ + +
Sbjct: 2454 ELERE----KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2509
Query: 1019 TEAHSRMSDL-------RGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKK 1071
+ +++ L +L E+Q+ + +Q Q+ + + + + V +K
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2569
Query: 1072 DRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQ 1126
EL+ LE+ R +E L E+ Q+ R++ Q + + H+E ++SQ
Sbjct: 2570 QEELQQLEQQRRQQEE-----LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Score = 105 bits (261), Expect = 4e-22
Identities = 171/744 (22%), Positives = 307/744 (41%), Gaps = 107/744 (14%)
Query: 260 EVAELSQKVSETTTSRQN-EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLC 318
EV L KV E R+ E+E +++ Q+ E A QK +Q+ + + + + L
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQKRLQAEEKAHAFAVQQKEQELQ 2066
Query: 319 QTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNK 378
QTL + S + L+ E E +R ++ + + + Q + +V + +
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARR-------AAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119
Query: 379 DKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRK 438
+ Q +A ++ E+L++E R AQ ++ L + Q D E E K AE
Sbjct: 2120 SAEEQAQAR-AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--- 2175
Query: 439 SCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHF--- 495
+TLR+K++VE++L LQL+E ++++++ L+R +
Sbjct: 2176 ---------QTLRQKAQVEQELTT----LRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222
Query: 496 RSQVIKATYG-------------------RAKPFRDKPVTD---QQLIEKITQVTEDNIN 533
RSQV + + RA RDK T Q+ EK+ QV E+
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 534 FQQKKWTLQKETQLSNSKQEETTENIEK-LRTSLDSCQACMKISCCSHDLKKEVDLLQHL 592
+ QL+ + EK L+ + + Q + LK E +LLQ
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQ- 2334
Query: 593 QVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGK 652
QK + L E+ EQ+ + L + + + + + +
Sbjct: 2335 ---------QKELAQEQARRLQ--EDKEQMAQQLA--EETQGFQRTLEAERQRQLEMSAE 2381
Query: 653 AAGASGREGEAERGEARARGEAQSQNQATDGREGGKALE--EYITQERNRAKETLEEERK 710
A R E R +ARA +AQ + + E G+ L E TQE+ +TLE +R
Sbjct: 2382 AERLKLRVAEMSRAQARAEEDAQRFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQR- 2438
Query: 711 RMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEK 770
Q+ + + ++A+A E R KE L++E +Q E + + V + + E
Sbjct: 2439 --QQSDHDAERLREAIA-----ELEREKEKLQQEAKLLQLKSEEM---QTVQQEQLLQET 2488
Query: 771 RKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLE---NRL 827
+ +++ SEK + E + Q+K E E KA++ E+++++ Q +E RL
Sbjct: 2489 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2548
Query: 828 TKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTK 887
EE ++ + + + + L +E+ Q+ + E L E+ L+ L E E +
Sbjct: 2549 VASMEEARRRQHEAEEGVRRKQEELQQLEQ-QRRQQEELLAEENQRLREQLQLLE-EQHR 2606
Query: 888 TKMIMVEERLILQQKMVKALQDEQES---------QRHGFEEEIMEYKEQIKQHAQTIVS 938
+ EE Q K L + +++ H F+ + Q Q A I+S
Sbjct: 2607 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILS 2665
Query: 939 LEEKLQKVTQHHKKIEGEIATLKD 962
EE LQ++ Q H ++ E+A +D
Sbjct: 2666 AEE-LQRLAQGHTTVD-ELARRED 2687
Score = 95.5 bits (236), Expect = 3e-19
Identities = 155/790 (19%), Positives = 332/790 (42%), Gaps = 111/790 (14%)
Query: 696 QERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQE----- 750
+E A++ EER+R+ E+E+ L +Q++ LA++ Q K + + +E Q R+QE
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 751 -------------LEERLARQKEVLESSIAHEKRKAKEA------LESEKRKVQDLENHL 791
++E L + ++ E+ I + R+A+ A +E E R V+
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 792 TQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQ-KEELELKEQKEDVLNNKL-S 849
+Q+ +E + + +A+EA E +K++ Q+ RL +Q ++E + K Q E L +++ +
Sbjct: 1465 ERQRGGAEGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1523
Query: 850 DALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQD 909
+A A E+ + +A E L+ ++ + AE+E + + +E ++ +
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-------TAQRSAEA 1576
Query: 910 EQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIE--------------- 954
E +S+R F E+ + + +++ + L E+ ++ Q + E
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1636
Query: 955 ------------GEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQK 1002
E+A K A E++ ++ E+ + A E + A++
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQ 1692
Query: 1003 EILSQQEVIMKLRKDLTEAHSRMSDLRGEL--NEKQKMELEQNVVLVQQQSKELSVLKEK 1060
E+ Q+++ + A + LR E E+Q+ LE+ + +Q +E + +K
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ---REAAAATQK 1749
Query: 1061 MAQMSSLVEKKDRELKAL-------EEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQ 1113
++ + + K E++ L EE R++ EK + +L E + + + + + +
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL----EAEAGRFRELAEEAAR 1805
Query: 1114 IEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHK 1173
+ + EA + Q+ ++ + + E V+ + A+ E E E A K
Sbjct: 1806 LRALAEEA----KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK--EK 1859
Query: 1174 DHQNESFLDL------KNLRMENNVQKILLDAKPDLPTLSRI--EILAPQNGLCNARFGS 1225
+ +NE L + R+E + D + L L + L Q GL
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1919
Query: 1226 AMEKSGKMDVAEA-LELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQ 1284
+ ++ +A E + ++ LG + + N + K + E + QL
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRS--NAEDTLRSKEQAELEAARQRQLAA 1977
Query: 1285 RDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDD------ 1338
+ + +++ L +EE R + +E++ R K +E + + E +
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037
Query: 1339 IYKEAEEKALLKE------ALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLR 1392
+ +EA +K L E A+++ E +L Q + +++ Q G +A+ + +E E R
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
Query: 1393 KETSSKSSQS 1402
+ +++QS
Sbjct: 2098 VQAEREAAQS 2107
Score = 94.0 bits (232), Expect = 9e-19
Identities = 244/1173 (20%), Positives = 470/1173 (40%), Gaps = 195/1173 (16%)
Query: 278 EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGEN 337
+KE +++C + Q E++ L ++ L KVL L E + +L++E E
Sbjct: 1012 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA--LPEPSPAAPTLRSELEL 1069
Query: 338 LKRDNAITSGMVSSLQKDILAKDEQVQQLK----EEVSHLKSQNKDKDHQLEALGSRCSV 393
L K EQV+ L E++ + + E L +
Sbjct: 1070 T------------------LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1111
Query: 394 LKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREK 453
LKE EL EA + LK + Q + + LR ELR + + + E+
Sbjct: 1112 LKEAQAVPATLPEL-EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1170
Query: 454 SKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQV------IKATYGRA 507
E+ +E + L + Q + + V + LE+ QL ++R ++ R
Sbjct: 1171 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1230
Query: 508 KPFRDKPVTDQQLI-EKITQ---VTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLR 563
+ + P+ D Q + E++ Q + E+ +K Q+ + + ++ + +
Sbjct: 1231 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1290
Query: 564 TSLDSCQACMK---ISCCSHDLKKE-VDLLQHL-QVSPPVSGLQKVVLDVLRHALSWLEE 618
L+ + K + S + +E VDL H +++ S K + + LR +EE
Sbjct: 1291 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR----MEE 1346
Query: 619 VEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQN 678
E+L QQ + +AA E + + EA A+ +AQ++
Sbjct: 1347 EERLAE--------------QQRAEERERLAEVEAA----LEKQRQLAEAHAQAKAQAER 1388
Query: 679 QATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVK 738
+A +E + ++E + + A + +++R +EL QQ + +++ Q K R
Sbjct: 1389 EA---KELQQRMQEEVVRREEAAVDAQQQKRSIQEEL-----QQLRQSSEAEIQAKARQA 1440
Query: 739 EALE------EEQTRVQELE-ERLARQKEVLESSIAH----------EKRKAKEALESEK 781
EA E EE+ RV L+ E RQ+ E + +KR+A+E E +
Sbjct: 1441 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1500
Query: 782 RKVQDLENHLTQQKEI-------SESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEEL 834
R+VQD E+ +Q E+ +E+ A EK++A +A+E+ + + ++ E RL ++ E+
Sbjct: 1501 RQVQD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL--RQAEV 1557
Query: 835 ELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVE 894
E Q + L A A E Q +A+ + K L L E + + V
Sbjct: 1558 ERARQVQVALETAQRSAEA---ELQSKRASFAEKTAQLERSLQE----------EHVAVA 1604
Query: 895 ERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIE 954
+ L+++ + Q + E++R E E + Q+K A + L + ++V Q +
Sbjct: 1605 Q---LREEAERRAQQQAEAERAREEAERELERWQLK--ANEALRLRLQAEEVAQQKSLAQ 1659
Query: 955 GEIATLKDNDPAPKEERPQ---DPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVI 1011
E K + A +E R + + E + +++ + + + A Q+ L+ ++ +
Sbjct: 1660 AEAE--KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR--LAAEQEL 1715
Query: 1012 MKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSV-LKEKMAQMSSLVEK 1070
++LR A + + + +L E++ L++ Q+ +EL L + A+M L+
Sbjct: 1716 IRLR-----AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Query: 1071 KDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQS 1130
K R EE R++ EK + +L E + + + + ++ + EA + Q+
Sbjct: 1771 KARA----EEESRSTSEKSKQRLEAEAG----RFRELAEEAARLRALAEEA----KRQRQ 1818
Query: 1131 FSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMEN 1190
++ + + E V+ + A+ E E E A K+ +NE L+ L +
Sbjct: 1819 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK--EKEAENER---LRRLAEDE 1873
Query: 1191 NVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMS 1250
Q+ R+E A Q+ K D+ E L K
Sbjct: 1874 AFQR------------RRLEEQAAQH---------------KADIEERLAQLRK------ 1900
Query: 1251 KTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRG 1310
S ++ G V R++ E+ + + +L+ +LGR
Sbjct: 1901 ---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR------- 1950
Query: 1311 YEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAI 1370
+ E RSK E+ ++ +L AEE+ +EA ER++ L E+ R
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLA------AEEERRRREAEERVQKSLAAEEEAARQR 2004
Query: 1371 RQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
+ + K+++ R LR+ +S++ L
Sbjct: 2005 KAALEEVERLKAKVEEARR-LRERAEQESARQL 2036
Score = 70.5 bits (171), Expect = 1e-11
Identities = 159/756 (21%), Positives = 301/756 (39%), Gaps = 103/756 (13%)
Query: 684 REGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEE 743
RE G Y Q+ ++ E +E R Q S L + L T+ +R++ L++
Sbjct: 956 REYGSCSHHY--QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1013
Query: 744 EQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHL--TQQKEISESN 801
E R E +R+A Q++ K A+ + E+EK + T + E+ +
Sbjct: 1014 EPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1071
Query: 802 IAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKT 861
E+ ++ A+ EK K L R T+ EE+ L+ +E + +E Q
Sbjct: 1072 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQL------------KEAQAV 1118
Query: 862 KATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDE----QE----- 912
AT L ELE TK + + + QQ AL+DE QE
Sbjct: 1119 PAT---------------LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1163
Query: 913 SQRHGFEE-EIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEER 971
QRHG + E+ ++E++ Q L E+ Q V + E+ L +E
Sbjct: 1164 QQRHGERDVEVERWRERVAQ-------LLERWQAVLAQTDVRQRELEQLGRQLRYYRES- 1215
Query: 972 PQDPLVAPMTESSAKDMAYEHL-IDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRG 1030
DPL A + ++ + + + + D A ++++ +Q ++ ++ + + +
Sbjct: 1216 -ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1274
Query: 1031 ELNEKQKMELEQNVVLVQ------------QQSKELSVLKEKM---AQMSSLVEKKDREL 1075
+N + EL+ Q QS SV++E + S L + +
Sbjct: 1275 YINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1334
Query: 1076 KALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLG 1135
K + E LR +E+ RL E++ R Q + A + +Q ++ +L
Sbjct: 1335 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1394
Query: 1136 VRCKGSRHEEVIQRQKKAL---SELRARIKELEKARSPDHKDHQNES----FLDLKNLRM 1188
R + EEV++R++ A+ + R+ +EL++ R + Q ++ + LR+
Sbjct: 1395 QRMQ----EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450
Query: 1189 ENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLD 1248
E ++ + L ++E Q G G+ E AE E ++ +
Sbjct: 1451 EEEIRVVRL----------QLEATERQRG------GAEGELQALRARAEEAEAQKRQAQE 1494
Query: 1249 MSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELL 1308
++ L +++ S + R K R+ + +L+ Q E L
Sbjct: 1495 EAERL--RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL 1552
Query: 1309 RGYEKDVEQLRRSKVSIEMYQ-SQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRIN 1367
R + +VE+ R+ +V++E Q S A+L+ AE+ A L+ +L+ + Q +
Sbjct: 1553 R--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1610
Query: 1368 RAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
QQ+ +A + + ERE+ R + + + L
Sbjct: 1611 ERRAQQQAEAERA--REEAERELERWQLKANEALRL 1644
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 134 bits (336), Expect = 8e-31
Identities = 263/1257 (20%), Positives = 491/1257 (39%), Gaps = 167/1257 (13%)
Query: 218 EEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSR-- 275
EE LA+Q + E L + + L ++ A + E EL Q++ E R
Sbjct: 1351 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1410
Query: 276 ------QNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEIT 329
Q ++ I ++ Q L + +A EIQ+ Q A ++ ++ EI
Sbjct: 1411 AAVDAQQQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSRLRI--------EEEIR 1459
Query: 330 SLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEA--- 386
++ + E +R G + +L+ + Q +Q +EE L+ Q +D+ +
Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1519
Query: 387 -LGSRCSVLKEELKQED----AHRELR-EAQEKELKLCKTQIQDMEKEMKKLRAELRKSC 440
L SR E +++ A ELR +A+E E +L + +++ + L R +
Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579
Query: 441 TEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLE-HFRSQV 499
E + EK+ E+ ++ + QL+E R + + ERA + E
Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1639
Query: 500 IKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENI 559
+KA + + V Q+ + + +++K ++E + +E+
Sbjct: 1640 LKANEALRLRLQAEEVAQQKSLAQ--------AEAEKQKEEAEREARRRGKAEEQAVRQR 1691
Query: 560 EKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEV 619
E L+ Q + L E +L++ L+ Q+ +L+ EE+
Sbjct: 1692 ELAEQELEK-QRQLAEGTAQQRLAAEQELIR-LRAETEQGEQQRQLLE---------EEL 1740
Query: 620 EQLLRDLGILPSSPN--KDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQ 677
+L R+ + ++ + V A KA +E+ + R EA
Sbjct: 1741 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1800
Query: 678 NQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALA---------- 727
+ + +AL E ++R A+E +R E E +LA++ A+
Sbjct: 1801 RELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIGEATRLKTEAE 1857
Query: 728 ---KSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKV 784
K E R++ E+E + + LEE+ A+ K +E +A ++ + LE +K V
Sbjct: 1858 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1917
Query: 785 QD-LENHLTQQKEISESNIAYEKRKA-KEAMEKEKKKVQDLENRLTKQKEELELKEQKED 842
+D L ++EI ++EK A K +E E +++ + KE+ EL+ ++
Sbjct: 1918 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ- 1976
Query: 843 VLNNKLSDALAMVEETQKTKATE----SLKAESLALKLNE-TLAELETTKTKMIMVEERL 897
LA EE ++ +A E SL AE A + + L E+E K K VEE
Sbjct: 1977 -------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK---VEEAR 2026
Query: 898 ILQQKMVKALQDEQESQRH---GFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHK--- 951
L+++ EQES R E + + K HA + E++LQ+ Q +
Sbjct: 2027 RLRERA------EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2080
Query: 952 -KIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEV 1010
++ GE + +E R Q A + ++ E L + Q
Sbjct: 2081 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA--ERLKQSAEEQAQARAQAQAA 2138
Query: 1011 IMKLRKDL-TEAHSRMSDLRGELNEKQ--KMELEQNVVLVQQQSKELSVLKEKMAQMSSL 1067
KLRK+ EA R + L +KQ E+E++ +Q ++ + +++++ +
Sbjct: 2139 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2198
Query: 1068 VEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQE 1127
+E+ D + L+E L+ +L E + R+++Q V E FS
Sbjct: 2199 LEETDHQKNLLDEELQ--------RLKAEATEAARQRSQ----------VEEELFS---- 2236
Query: 1128 QQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLR 1187
++ Q + LS+L+ARI+ +A KD+ + FL + +
Sbjct: 2237 -------------------VRVQMEELSKLKARIEAENRALILRDKDN-TQRFLQEEAEK 2276
Query: 1188 MENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALEL-SEKLY 1246
M+ V + +R+ LA ++ M K V EA L +E
Sbjct: 2277 MK-QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2335
Query: 1247 LDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQL----RQRDLDLVFD------KITQ 1296
L K L + M +E + + RQR L++ + ++ +
Sbjct: 2336 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2395
Query: 1297 LKNQLGRKEELLRGYEKDVEQ----LRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEA 1352
+ R EE + + K E+ L R++++ + + V LE + + L+EA
Sbjct: 2396 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2455
Query: 1353 LERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPS 1409
+ +E + +EK A K+ K+ ++E L +ET + QS L K S
Sbjct: 2456 IAELERE--KEKLQQEA----KLLQLKSEEMQTVQQEQLLQETQA-LQQSFLSEKDS 2505
Score = 129 bits (324), Expect = 2e-29
Identities = 242/1276 (18%), Positives = 500/1276 (39%), Gaps = 178/1276 (13%)
Query: 250 KDVIIANLQNEVAELSQK----VSETTTSRQNEKEISQKCQVLDEDID---AKQKEIQSL 302
+DV + + VA+L ++ +++T ++ +++ ++ + E D A ++ +
Sbjct: 1174 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1233
Query: 303 KSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQ 362
+ QI A+ S+ + + L + + + ++ GE ++ +++++ L
Sbjct: 1234 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1293
Query: 363 VQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQI 422
QL+ S K + SV++E + + EL + +K +
Sbjct: 1294 KAQLEPVASPAKKPKVQSGSE--------SVIQEYVDLRTHYSELTTLTSQYIKFISETL 1345
Query: 423 QDMEKEMK---KLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRES 479
+ ME+E + + RAE R+ E R+ ++ + + + R+ +LQ+ E
Sbjct: 1346 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1405
Query: 480 V-----------IKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKI---T 525
V K +++ + QL I+A +A+ + ++ I +
Sbjct: 1406 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1465
Query: 526 QVTE-DNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSL-DSCQACMKISCCSHDLK 583
+ TE + + L+ + + +++ + E E+LR + D Q +
Sbjct: 1466 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---------RKRQ 1516
Query: 584 KEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSG 643
EV+L ++ + ++ L L EE E+ LR + QVQ
Sbjct: 1517 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV----ERARQVQ---- 1568
Query: 644 NSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQ--ERNRA 701
A+ TA ++A A + A E A+ E Q + + + E Q E RA
Sbjct: 1569 -VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1627
Query: 702 KETLEEERKRMQ-----ELESLLAQQKKALAKSITQ-EKNRVKEALEEEQTRVQELEERL 755
+E E E +R Q L L ++ A KS+ Q E + KE E E R + EE+
Sbjct: 1628 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687
Query: 756 ARQKEVLESSIAHEKRKA------KEALESEKRKVQDLENHLTQQKEISESNIAYEKRKA 809
RQ+E+ E + +++ A + A E E +++ QQ+++ E +A +R+A
Sbjct: 1688 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1747
Query: 810 KEAMEKEKKKVQDL-------------------ENRLT--KQKEELELKEQKEDVLNNKL 848
A +K ++ +L E+R T K K+ LE + + L +
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1807
Query: 849 SDALAMVEETQKTK-------ATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQ 901
+ A+ EE ++ + A + +AE + + + E KT+ + + +
Sbjct: 1808 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1867
Query: 902 KMVKALQDEQESQRHGFEEEIMEYKEQI-----------------------------KQH 932
+ ++ L +++ QR EE+ ++K I +Q
Sbjct: 1868 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1927
Query: 933 AQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAP-----MTESSAKD 987
+ I++L+ +K ++E E+ ++ N + Q L A E +
Sbjct: 1928 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1987
Query: 988 MAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLV 1047
E + LAA++E Q++ + +++ +++ + R L E+ + E + + L
Sbjct: 1988 REAEERVQKSLAAEEEAARQRKAAL---EEVERLKAKVEEAR-RLRERAEQESARQLQLA 2043
Query: 1048 QQQSKELSVLKEKMAQMSSLVEKKDREL-------KALEEALRASQEKHRLQLNTEKEQK 1100
Q+ +++ +EK + V++K++EL +++ + LR E R +E +
Sbjct: 2044 QEAAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2101
Query: 1101 PRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRA- 1159
+ + + + Q+E S+ ++ Q+ + + R E + ++A +E A
Sbjct: 2102 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2161
Query: 1160 RIKELEKARSPDHKDHQNESF-------LDLKNLRM---ENNVQKILLDAKPDLPTLSRI 1209
R K+ A HK ++ +L LR+ E + QK LLD +
Sbjct: 2162 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2221
Query: 1210 EILAPQNGLCNARFG--SAMEKSGKMDVAEALELSEKLYLDMSKTLGSLM----NIKNMS 1263
E ++ + F ME+ K+ E + D T L +K ++
Sbjct: 2222 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2281
Query: 1264 GHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKV 1323
+ ++ QE ++ QL + D L Q E++L+ + V++ R K
Sbjct: 2282 EEAARLSVAAQEAARLRQLAEED----------LAQQRALAEKMLKEKMQAVQEATRLKA 2331
Query: 1324 SIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLK 1383
E+ Q Q + E+ L+E E+M QL +E + ++ R+ L+
Sbjct: 2332 EAELLQQQKELAQ-------EQARRLQEDKEQMAQQLAEE---TQGFQRTLEAERQRQLE 2381
Query: 1384 MDQEREMLRKETSSKS 1399
M E E L+ + S
Sbjct: 2382 MSAEAERLKLRVAEMS 2397
Score = 116 bits (290), Expect = 2e-25
Identities = 189/955 (19%), Positives = 410/955 (42%), Gaps = 92/955 (9%)
Query: 240 LSDYEIESKYKDVIIANLQNEVA---ELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQ 296
L++ E+E K + + Q +A EL + +ET Q + + ++ L + A
Sbjct: 1693 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1751
Query: 297 KEIQSLKSQISALQKGY-----SKVLCQTLSERNSEITSLKNEGE-----NLKRDNAITS 346
++ Q L+++++ ++ SK + S SE + + E E L + A
Sbjct: 1752 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1811
Query: 347 GMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSV-LKEELKQEDAHR 405
+ ++ +E + + E + ++ + L + + LKE+ + + R
Sbjct: 1812 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1871
Query: 406 ELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCT-----EQSVISRTLREKSKVEEK- 459
L E + + + + Q + ++++ A+LRK+ ++ ++ TLR++ +VEE+
Sbjct: 1872 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1931
Query: 460 --LQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTD 517
L+ + E+ I+ N E + E + + A+ R + +
Sbjct: 1932 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1991
Query: 518 QQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETT-------ENIEKLRTSLDSCQ 570
+++ + + E +Q+K L++ +L +E E+ +L+ + ++ Q
Sbjct: 1992 ERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2048
Query: 571 ACMKISCCSHDL---KKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVE-QLLRDL 626
++ +H +KE +L Q LQ V + + R A EE Q R+
Sbjct: 2049 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2108
Query: 627 GILPSSPNK-DQVQQFSGNSAVFTAGKAAGASGREGEAERGEAR---ARGEAQSQNQATD 682
+ ++++Q + A A A A EAE+ AR A A Q QA D
Sbjct: 2109 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2168
Query: 683 GR-EGGKALEEYITQERNRAKETLEEERKRMQELE---SLL---AQQKKALAKSITQEKN 735
E K E +++ + ++ L R +++E + +LL Q+ KA A ++++
Sbjct: 2169 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2228
Query: 736 RVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQ- 794
+V+E L + +++EL + AR + + I +K + L+ E K++ + +
Sbjct: 2229 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2288
Query: 795 ---------KEISESNIAYEKRKAKEAMEKEKKKVQDL-----ENRLTKQKEELELKEQK 840
++++E ++A ++ A++ ++++ + VQ+ E L +Q++EL +EQ
Sbjct: 2289 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA-QEQA 2347
Query: 841 EDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQ 900
+ +K A + EETQ + T L+AE + E AE E K ++ +
Sbjct: 2348 RRLQEDKEQMAQQLAEETQGFQRT--LEAERQ--RQLEMSAEAERLKLRVAE------MS 2397
Query: 901 QKMVKALQDEQESQRHGFE-EEIMEYKEQIKQHAQTIV-SLEEKLQKVTQHHKKIEGEIA 958
+ +A +D Q ++ E E + E Q T+V +LE + Q+ +++ IA
Sbjct: 2398 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2457
Query: 959 TLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDL 1018
L+ KE+ Q+ + + + + E L+ + A Q+ LS+++ +++ + +
Sbjct: 2458 ELERE----KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2513
Query: 1019 TEAHSRMSDL-------RGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKK 1071
+ +++ L +L E+Q+ + +Q Q+ + + + + V +K
Sbjct: 2514 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2573
Query: 1072 DRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQ 1126
EL+ LE+ R +E L E+ Q+ R++ Q + + H+E ++SQ
Sbjct: 2574 QEELQQLEQQRRQQEE-----LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2623
Score = 105 bits (261), Expect = 4e-22
Identities = 171/744 (22%), Positives = 307/744 (41%), Gaps = 107/744 (14%)
Query: 260 EVAELSQKVSETTTSRQN-EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLC 318
EV L KV E R+ E+E +++ Q+ E A QK +Q+ + + + + L
Sbjct: 2014 EVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQKRLQAEEKAHAFAVQQKEQELQ 2070
Query: 319 QTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNK 378
QTL + S + L+ E E +R ++ + + + Q + +V + +
Sbjct: 2071 QTLQQEQSVLDQLRGEAEAARR-------AAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2123
Query: 379 DKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRK 438
+ Q +A ++ E+L++E R AQ ++ L + Q D E E K AE
Sbjct: 2124 SAEEQAQAR-AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--- 2179
Query: 439 SCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHF--- 495
+TLR+K++VE++L LQL+E ++++++ L+R +
Sbjct: 2180 ---------QTLRQKAQVEQELTT----LRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2226
Query: 496 RSQVIKATYG-------------------RAKPFRDKPVTD---QQLIEKITQVTEDNIN 533
RSQV + + RA RDK T Q+ EK+ QV E+
Sbjct: 2227 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2286
Query: 534 FQQKKWTLQKETQLSNSKQEETTENIEK-LRTSLDSCQACMKISCCSHDLKKEVDLLQHL 592
+ QL+ + EK L+ + + Q + LK E +LLQ
Sbjct: 2287 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQ- 2338
Query: 593 QVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGK 652
QK + L E+ EQ+ + L + + + + + +
Sbjct: 2339 ---------QKELAQEQARRLQ--EDKEQMAQQLA--EETQGFQRTLEAERQRQLEMSAE 2385
Query: 653 AAGASGREGEAERGEARARGEAQSQNQATDGREGGKALE--EYITQERNRAKETLEEERK 710
A R E R +ARA +AQ + + E G+ L E TQE+ +TLE +R
Sbjct: 2386 AERLKLRVAEMSRAQARAEEDAQRFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQR- 2442
Query: 711 RMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEK 770
Q+ + + ++A+A E R KE L++E +Q E + + V + + E
Sbjct: 2443 --QQSDHDAERLREAIA-----ELEREKEKLQQEAKLLQLKSEEM---QTVQQEQLLQET 2492
Query: 771 RKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLE---NRL 827
+ +++ SEK + E + Q+K E E KA++ E+++++ Q +E RL
Sbjct: 2493 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2552
Query: 828 TKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTK 887
EE ++ + + + + L +E+ Q+ + E L E+ L+ L E E +
Sbjct: 2553 VASMEEARRRQHEAEEGVRRKQEELQQLEQ-QRRQQEELLAEENQRLREQLQLLE-EQHR 2610
Query: 888 TKMIMVEERLILQQKMVKALQDEQES---------QRHGFEEEIMEYKEQIKQHAQTIVS 938
+ EE Q K L + +++ H F+ + Q Q A I+S
Sbjct: 2611 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILS 2669
Query: 939 LEEKLQKVTQHHKKIEGEIATLKD 962
EE LQ++ Q H ++ E+A +D
Sbjct: 2670 AEE-LQRLAQGHTTVD-ELARRED 2691
Score = 95.5 bits (236), Expect = 3e-19
Identities = 155/790 (19%), Positives = 332/790 (42%), Gaps = 111/790 (14%)
Query: 696 QERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQE----- 750
+E A++ EER+R+ E+E+ L +Q++ LA++ Q K + + +E Q R+QE
Sbjct: 1350 EEERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQRMQEEVVRR 1408
Query: 751 -------------LEERLARQKEVLESSIAHEKRKAKEA------LESEKRKVQDLENHL 791
++E L + ++ E+ I + R+A+ A +E E R V+
Sbjct: 1409 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1468
Query: 792 TQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQ-KEELELKEQKEDVLNNKL-S 849
+Q+ +E + + +A+EA E +K++ Q+ RL +Q ++E + K Q E L +++ +
Sbjct: 1469 ERQRGGAEGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1527
Query: 850 DALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQD 909
+A A E+ + +A E L+ ++ + AE+E + + +E ++ +
Sbjct: 1528 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-------TAQRSAEA 1580
Query: 910 EQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIE--------------- 954
E +S+R F E+ + + +++ + L E+ ++ Q + E
Sbjct: 1581 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1640
Query: 955 ------------GEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQK 1002
E+A K A E++ ++ E+ + A E + A++
Sbjct: 1641 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQ 1696
Query: 1003 EILSQQEVIMKLRKDLTEAHSRMSDLRGEL--NEKQKMELEQNVVLVQQQSKELSVLKEK 1060
E+ Q+++ + A + LR E E+Q+ LE+ + +Q +E + +K
Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ---REAAAATQK 1753
Query: 1061 MAQMSSLVEKKDRELKAL-------EEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQ 1113
++ + + K E++ L EE R++ EK + +L E + + + + + +
Sbjct: 1754 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL----EAEAGRFRELAEEAAR 1809
Query: 1114 IEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHK 1173
+ + EA + Q+ ++ + + E V+ + A+ E E E A K
Sbjct: 1810 LRALAEEA----KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK--EK 1863
Query: 1174 DHQNESFLDL------KNLRMENNVQKILLDAKPDLPTLSRI--EILAPQNGLCNARFGS 1225
+ +NE L + R+E + D + L L + L Q GL
Sbjct: 1864 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1923
Query: 1226 AMEKSGKMDVAEA-LELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQ 1284
+ ++ +A E + ++ LG + + N + K + E + QL
Sbjct: 1924 RRQVEEEILALKASFEKAAAGKAELELELGRIRS--NAEDTLRSKEQAELEAARQRQLAA 1981
Query: 1285 RDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDD------ 1338
+ + +++ L +EE R + +E++ R K +E + + E +
Sbjct: 1982 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2041
Query: 1339 IYKEAEEKALLKE------ALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLR 1392
+ +EA +K L E A+++ E +L Q + +++ Q G +A+ + +E E R
Sbjct: 2042 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2101
Query: 1393 KETSSKSSQS 1402
+ +++QS
Sbjct: 2102 VQAEREAAQS 2111
Score = 94.0 bits (232), Expect = 9e-19
Identities = 244/1173 (20%), Positives = 470/1173 (40%), Gaps = 195/1173 (16%)
Query: 278 EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGEN 337
+KE +++C + Q E++ L ++ L KVL L E + +L++E E
Sbjct: 1016 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA--LPEPSPAAPTLRSELEL 1073
Query: 338 LKRDNAITSGMVSSLQKDILAKDEQVQQLK----EEVSHLKSQNKDKDHQLEALGSRCSV 393
L K EQV+ L E++ + + E L +
Sbjct: 1074 T------------------LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1115
Query: 394 LKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREK 453
LKE EL EA + LK + Q + + LR ELR + + + E+
Sbjct: 1116 LKEAQAVPATLPEL-EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1174
Query: 454 SKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQV------IKATYGRA 507
E+ +E + L + Q + + V + LE+ QL ++R ++ R
Sbjct: 1175 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1234
Query: 508 KPFRDKPVTDQQLI-EKITQ---VTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLR 563
+ + P+ D Q + E++ Q + E+ +K Q+ + + ++ + +
Sbjct: 1235 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1294
Query: 564 TSLDSCQACMK---ISCCSHDLKKE-VDLLQHL-QVSPPVSGLQKVVLDVLRHALSWLEE 618
L+ + K + S + +E VDL H +++ S K + + LR +EE
Sbjct: 1295 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR----MEE 1350
Query: 619 VEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQN 678
E+L QQ + +AA E + + EA A+ +AQ++
Sbjct: 1351 EERLAE--------------QQRAEERERLAEVEAA----LEKQRQLAEAHAQAKAQAER 1392
Query: 679 QATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVK 738
+A +E + ++E + + A + +++R +EL QQ + +++ Q K R
Sbjct: 1393 EA---KELQQRMQEEVVRREEAAVDAQQQKRSIQEEL-----QQLRQSSEAEIQAKARQA 1444
Query: 739 EALE------EEQTRVQELE-ERLARQKEVLESSIAH----------EKRKAKEALESEK 781
EA E EE+ RV L+ E RQ+ E + +KR+A+E E +
Sbjct: 1445 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1504
Query: 782 RKVQDLENHLTQQKEI-------SESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEEL 834
R+VQD E+ +Q E+ +E+ A EK++A +A+E+ + + ++ E RL ++ E+
Sbjct: 1505 RQVQD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL--RQAEV 1561
Query: 835 ELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVE 894
E Q + L A A E Q +A+ + K L L E + + V
Sbjct: 1562 ERARQVQVALETAQRSAEA---ELQSKRASFAEKTAQLERSLQE----------EHVAVA 1608
Query: 895 ERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIE 954
+ L+++ + Q + E++R E E + Q+K A + L + ++V Q +
Sbjct: 1609 Q---LREEAERRAQQQAEAERAREEAERELERWQLK--ANEALRLRLQAEEVAQQKSLAQ 1663
Query: 955 GEIATLKDNDPAPKEERPQ---DPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVI 1011
E K + A +E R + + E + +++ + + + A Q+ L+ ++ +
Sbjct: 1664 AEAE--KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR--LAAEQEL 1719
Query: 1012 MKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSV-LKEKMAQMSSLVEK 1070
++LR A + + + +L E++ L++ Q+ +EL L + A+M L+
Sbjct: 1720 IRLR-----AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1774
Query: 1071 KDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQS 1130
K R EE R++ EK + +L E + + + + ++ + EA + Q+
Sbjct: 1775 KARA----EEESRSTSEKSKQRLEAEAG----RFRELAEEAARLRALAEEA----KRQRQ 1822
Query: 1131 FSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMEN 1190
++ + + E V+ + A+ E E E A K+ +NE L+ L +
Sbjct: 1823 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK--EKEAENER---LRRLAEDE 1877
Query: 1191 NVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMS 1250
Q+ R+E A Q+ K D+ E L K
Sbjct: 1878 AFQR------------RRLEEQAAQH---------------KADIEERLAQLRK------ 1904
Query: 1251 KTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRG 1310
S ++ G V R++ E+ + + +L+ +LGR
Sbjct: 1905 ---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR------- 1954
Query: 1311 YEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAI 1370
+ E RSK E+ ++ +L AEE+ +EA ER++ L E+ R
Sbjct: 1955 IRSNAEDTLRSKEQAELEAARQRQLA------AEEERRRREAEERVQKSLAAEEEAARQR 2008
Query: 1371 RQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
+ + K+++ R LR+ +S++ L
Sbjct: 2009 KAALEEVERLKAKVEEARR-LRERAEQESARQL 2040
Score = 70.5 bits (171), Expect = 1e-11
Identities = 159/756 (21%), Positives = 301/756 (39%), Gaps = 103/756 (13%)
Query: 684 REGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEE 743
RE G Y Q+ ++ E +E R Q S L + L T+ +R++ L++
Sbjct: 960 REYGSCSHHY--QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1017
Query: 744 EQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHL--TQQKEISESN 801
E R E +R+A Q++ K A+ + E+EK + T + E+ +
Sbjct: 1018 EPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1075
Query: 802 IAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKT 861
E+ ++ A+ EK K L R T+ EE+ L+ +E + +E Q
Sbjct: 1076 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQL------------KEAQAV 1122
Query: 862 KATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDE----QE----- 912
AT L ELE TK + + + QQ AL+DE QE
Sbjct: 1123 PAT---------------LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1167
Query: 913 SQRHGFEE-EIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEER 971
QRHG + E+ ++E++ Q L E+ Q V + E+ L +E
Sbjct: 1168 QQRHGERDVEVERWRERVAQ-------LLERWQAVLAQTDVRQRELEQLGRQLRYYRES- 1219
Query: 972 PQDPLVAPMTESSAKDMAYEHL-IDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRG 1030
DPL A + ++ + + + + D A ++++ +Q ++ ++ + + +
Sbjct: 1220 -ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1278
Query: 1031 ELNEKQKMELEQNVVLVQ------------QQSKELSVLKEKM---AQMSSLVEKKDREL 1075
+N + EL+ Q QS SV++E + S L + +
Sbjct: 1279 YINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1338
Query: 1076 KALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLG 1135
K + E LR +E+ RL E++ R Q + A + +Q ++ +L
Sbjct: 1339 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1398
Query: 1136 VRCKGSRHEEVIQRQKKAL---SELRARIKELEKARSPDHKDHQNES----FLDLKNLRM 1188
R + EEV++R++ A+ + R+ +EL++ R + Q ++ + LR+
Sbjct: 1399 QRMQ----EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1454
Query: 1189 ENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLD 1248
E ++ + L ++E Q G G+ E AE E ++ +
Sbjct: 1455 EEEIRVVRL----------QLEATERQRG------GAEGELQALRARAEEAEAQKRQAQE 1498
Query: 1249 MSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELL 1308
++ L +++ S + R K R+ + +L+ Q E L
Sbjct: 1499 EAERL--RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL 1556
Query: 1309 RGYEKDVEQLRRSKVSIEMYQ-SQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRIN 1367
R + +VE+ R+ +V++E Q S A+L+ AE+ A L+ +L+ + Q +
Sbjct: 1557 R--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1614
Query: 1368 RAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
QQ+ +A + + ERE+ R + + + L
Sbjct: 1615 ERRAQQQAEAERA--REEAERELERWQLKANEALRL 1648
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 134 bits (336), Expect = 8e-31
Identities = 263/1257 (20%), Positives = 491/1257 (39%), Gaps = 167/1257 (13%)
Query: 218 EEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSR-- 275
EE LA+Q + E L + + L ++ A + E EL Q++ E R
Sbjct: 1347 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1406
Query: 276 ------QNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEIT 329
Q ++ I ++ Q L + +A EIQ+ Q A ++ ++ EI
Sbjct: 1407 AAVDAQQQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSRLRI--------EEEIR 1455
Query: 330 SLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEA--- 386
++ + E +R G + +L+ + Q +Q +EE L+ Q +D+ +
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 387 -LGSRCSVLKEELKQED----AHRELR-EAQEKELKLCKTQIQDMEKEMKKLRAELRKSC 440
L SR E +++ A ELR +A+E E +L + +++ + L R +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 441 TEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLE-HFRSQV 499
E + EK+ E+ ++ + QL+E R + + ERA + E
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 500 IKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENI 559
+KA + + V Q+ + + +++K ++E + +E+
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQ--------AEAEKQKEEAEREARRRGKAEEQAVRQR 1687
Query: 560 EKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEV 619
E L+ Q + L E +L++ L+ Q+ +L+ EE+
Sbjct: 1688 ELAEQELEK-QRQLAEGTAQQRLAAEQELIR-LRAETEQGEQQRQLLE---------EEL 1736
Query: 620 EQLLRDLGILPSSPN--KDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQ 677
+L R+ + ++ + V A KA +E+ + R EA
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1796
Query: 678 NQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALA---------- 727
+ + +AL E ++R A+E +R E E +LA++ A+
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIGEATRLKTEAE 1853
Query: 728 ---KSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKV 784
K E R++ E+E + + LEE+ A+ K +E +A ++ + LE +K V
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1913
Query: 785 QD-LENHLTQQKEISESNIAYEKRKA-KEAMEKEKKKVQDLENRLTKQKEELELKEQKED 842
+D L ++EI ++EK A K +E E +++ + KE+ EL+ ++
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ- 1972
Query: 843 VLNNKLSDALAMVEETQKTKATE----SLKAESLALKLNE-TLAELETTKTKMIMVEERL 897
LA EE ++ +A E SL AE A + + L E+E K K VEE
Sbjct: 1973 -------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK---VEEAR 2022
Query: 898 ILQQKMVKALQDEQESQRH---GFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHK--- 951
L+++ EQES R E + + K HA + E++LQ+ Q +
Sbjct: 2023 RLRERA------EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076
Query: 952 -KIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEV 1010
++ GE + +E R Q A + ++ E L + Q
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA--ERLKQSAEEQAQARAQAQAA 2134
Query: 1011 IMKLRKDL-TEAHSRMSDLRGELNEKQ--KMELEQNVVLVQQQSKELSVLKEKMAQMSSL 1067
KLRK+ EA R + L +KQ E+E++ +Q ++ + +++++ +
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2194
Query: 1068 VEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQE 1127
+E+ D + L+E L+ +L E + R+++Q V E FS
Sbjct: 2195 LEETDHQKNLLDEELQ--------RLKAEATEAARQRSQ----------VEEELFS---- 2232
Query: 1128 QQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLR 1187
++ Q + LS+L+ARI+ +A KD+ + FL + +
Sbjct: 2233 -------------------VRVQMEELSKLKARIEAENRALILRDKDN-TQRFLQEEAEK 2272
Query: 1188 MENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALEL-SEKLY 1246
M+ V + +R+ LA ++ M K V EA L +E
Sbjct: 2273 MK-QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2331
Query: 1247 LDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQL----RQRDLDLVFD------KITQ 1296
L K L + M +E + + RQR L++ + ++ +
Sbjct: 2332 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2391
Query: 1297 LKNQLGRKEELLRGYEKDVEQ----LRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEA 1352
+ R EE + + K E+ L R++++ + + V LE + + L+EA
Sbjct: 2392 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2451
Query: 1353 LERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPS 1409
+ +E + +EK A K+ K+ ++E L +ET + QS L K S
Sbjct: 2452 IAELERE--KEKLQQEA----KLLQLKSEEMQTVQQEQLLQETQA-LQQSFLSEKDS 2501
Score = 129 bits (324), Expect = 2e-29
Identities = 242/1276 (18%), Positives = 500/1276 (39%), Gaps = 178/1276 (13%)
Query: 250 KDVIIANLQNEVAELSQK----VSETTTSRQNEKEISQKCQVLDEDID---AKQKEIQSL 302
+DV + + VA+L ++ +++T ++ +++ ++ + E D A ++ +
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1229
Query: 303 KSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQ 362
+ QI A+ S+ + + L + + + ++ GE ++ +++++ L
Sbjct: 1230 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1289
Query: 363 VQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQI 422
QL+ S K + SV++E + + EL + +K +
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSE--------SVIQEYVDLRTHYSELTTLTSQYIKFISETL 1341
Query: 423 QDMEKEMK---KLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRES 479
+ ME+E + + RAE R+ E R+ ++ + + + R+ +LQ+ E
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 480 V-----------IKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKI---T 525
V K +++ + QL I+A +A+ + ++ I +
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 526 QVTE-DNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSL-DSCQACMKISCCSHDLK 583
+ TE + + L+ + + +++ + E E+LR + D Q +
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---------RKRQ 1512
Query: 584 KEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSG 643
EV+L ++ + ++ L L EE E+ LR + QVQ
Sbjct: 1513 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV----ERARQVQ---- 1564
Query: 644 NSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQ--ERNRA 701
A+ TA ++A A + A E A+ E Q + + + E Q E RA
Sbjct: 1565 -VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1623
Query: 702 KETLEEERKRMQ-----ELESLLAQQKKALAKSITQ-EKNRVKEALEEEQTRVQELEERL 755
+E E E +R Q L L ++ A KS+ Q E + KE E E R + EE+
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 756 ARQKEVLESSIAHEKRKA------KEALESEKRKVQDLENHLTQQKEISESNIAYEKRKA 809
RQ+E+ E + +++ A + A E E +++ QQ+++ E +A +R+A
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 810 KEAMEKEKKKVQDL-------------------ENRLT--KQKEELELKEQKEDVLNNKL 848
A +K ++ +L E+R T K K+ LE + + L +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 849 SDALAMVEETQKTK-------ATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQ 901
+ A+ EE ++ + A + +AE + + + E KT+ + + +
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 902 KMVKALQDEQESQRHGFEEEIMEYKEQI-----------------------------KQH 932
+ ++ L +++ QR EE+ ++K I +Q
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 933 AQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAP-----MTESSAKD 987
+ I++L+ +K ++E E+ ++ N + Q L A E +
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983
Query: 988 MAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLV 1047
E + LAA++E Q++ + +++ +++ + R L E+ + E + + L
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAAL---EEVERLKAKVEEAR-RLRERAEQESARQLQLA 2039
Query: 1048 QQQSKELSVLKEKMAQMSSLVEKKDREL-------KALEEALRASQEKHRLQLNTEKEQK 1100
Q+ +++ +EK + V++K++EL +++ + LR E R +E +
Sbjct: 2040 QEAAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
Query: 1101 PRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRA- 1159
+ + + + Q+E S+ ++ Q+ + + R E + ++A +E A
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 1160 RIKELEKARSPDHKDHQNESF-------LDLKNLRM---ENNVQKILLDAKPDLPTLSRI 1209
R K+ A HK ++ +L LR+ E + QK LLD +
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2217
Query: 1210 EILAPQNGLCNARFG--SAMEKSGKMDVAEALELSEKLYLDMSKTLGSLM----NIKNMS 1263
E ++ + F ME+ K+ E + D T L +K ++
Sbjct: 2218 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2277
Query: 1264 GHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKV 1323
+ ++ QE ++ QL + D L Q E++L+ + V++ R K
Sbjct: 2278 EEAARLSVAAQEAARLRQLAEED----------LAQQRALAEKMLKEKMQAVQEATRLKA 2327
Query: 1324 SIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLK 1383
E+ Q Q + E+ L+E E+M QL +E + ++ R+ L+
Sbjct: 2328 EAELLQQQKELAQ-------EQARRLQEDKEQMAQQLAEE---TQGFQRTLEAERQRQLE 2377
Query: 1384 MDQEREMLRKETSSKS 1399
M E E L+ + S
Sbjct: 2378 MSAEAERLKLRVAEMS 2393
Score = 116 bits (290), Expect = 2e-25
Identities = 189/955 (19%), Positives = 410/955 (42%), Gaps = 92/955 (9%)
Query: 240 LSDYEIESKYKDVIIANLQNEVA---ELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQ 296
L++ E+E K + + Q +A EL + +ET Q + + ++ L + A
Sbjct: 1689 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747
Query: 297 KEIQSLKSQISALQKGY-----SKVLCQTLSERNSEITSLKNEGE-----NLKRDNAITS 346
++ Q L+++++ ++ SK + S SE + + E E L + A
Sbjct: 1748 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807
Query: 347 GMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSV-LKEELKQEDAHR 405
+ ++ +E + + E + ++ + L + + LKE+ + + R
Sbjct: 1808 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1867
Query: 406 ELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCT-----EQSVISRTLREKSKVEEK- 459
L E + + + + Q + ++++ A+LRK+ ++ ++ TLR++ +VEE+
Sbjct: 1868 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1927
Query: 460 --LQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTD 517
L+ + E+ I+ N E + E + + A+ R + +
Sbjct: 1928 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1987
Query: 518 QQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETT-------ENIEKLRTSLDSCQ 570
+++ + + E +Q+K L++ +L +E E+ +L+ + ++ Q
Sbjct: 1988 ERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2044
Query: 571 ACMKISCCSHDL---KKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVE-QLLRDL 626
++ +H +KE +L Q LQ V + + R A EE Q R+
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 627 GILPSSPNK-DQVQQFSGNSAVFTAGKAAGASGREGEAERGEAR---ARGEAQSQNQATD 682
+ ++++Q + A A A A EAE+ AR A A Q QA D
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Query: 683 GR-EGGKALEEYITQERNRAKETLEEERKRMQELE---SLL---AQQKKALAKSITQEKN 735
E K E +++ + ++ L R +++E + +LL Q+ KA A ++++
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224
Query: 736 RVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQ- 794
+V+E L + +++EL + AR + + I +K + L+ E K++ + +
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284
Query: 795 ---------KEISESNIAYEKRKAKEAMEKEKKKVQDL-----ENRLTKQKEELELKEQK 840
++++E ++A ++ A++ ++++ + VQ+ E L +Q++EL +EQ
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA-QEQA 2343
Query: 841 EDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQ 900
+ +K A + EETQ + T L+AE + E AE E K ++ +
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRT--LEAERQ--RQLEMSAEAERLKLRVAE------MS 2393
Query: 901 QKMVKALQDEQESQRHGFE-EEIMEYKEQIKQHAQTIV-SLEEKLQKVTQHHKKIEGEIA 958
+ +A +D Q ++ E E + E Q T+V +LE + Q+ +++ IA
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453
Query: 959 TLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDL 1018
L+ KE+ Q+ + + + + E L+ + A Q+ LS+++ +++ + +
Sbjct: 2454 ELERE----KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2509
Query: 1019 TEAHSRMSDL-------RGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKK 1071
+ +++ L +L E+Q+ + +Q Q+ + + + + V +K
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2569
Query: 1072 DRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQ 1126
EL+ LE+ R +E L E+ Q+ R++ Q + + H+E ++SQ
Sbjct: 2570 QEELQQLEQQRRQQEE-----LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Score = 105 bits (261), Expect = 4e-22
Identities = 171/744 (22%), Positives = 307/744 (41%), Gaps = 107/744 (14%)
Query: 260 EVAELSQKVSETTTSRQN-EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLC 318
EV L KV E R+ E+E +++ Q+ E A QK +Q+ + + + + L
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQKRLQAEEKAHAFAVQQKEQELQ 2066
Query: 319 QTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNK 378
QTL + S + L+ E E +R ++ + + + Q + +V + +
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARR-------AAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119
Query: 379 DKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRK 438
+ Q +A ++ E+L++E R AQ ++ L + Q D E E K AE
Sbjct: 2120 SAEEQAQAR-AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--- 2175
Query: 439 SCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHF--- 495
+TLR+K++VE++L LQL+E ++++++ L+R +
Sbjct: 2176 ---------QTLRQKAQVEQELTT----LRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222
Query: 496 RSQVIKATYG-------------------RAKPFRDKPVTD---QQLIEKITQVTEDNIN 533
RSQV + + RA RDK T Q+ EK+ QV E+
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 534 FQQKKWTLQKETQLSNSKQEETTENIEK-LRTSLDSCQACMKISCCSHDLKKEVDLLQHL 592
+ QL+ + EK L+ + + Q + LK E +LLQ
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQ- 2334
Query: 593 QVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGK 652
QK + L E+ EQ+ + L + + + + + +
Sbjct: 2335 ---------QKELAQEQARRLQ--EDKEQMAQQLA--EETQGFQRTLEAERQRQLEMSAE 2381
Query: 653 AAGASGREGEAERGEARARGEAQSQNQATDGREGGKALE--EYITQERNRAKETLEEERK 710
A R E R +ARA +AQ + + E G+ L E TQE+ +TLE +R
Sbjct: 2382 AERLKLRVAEMSRAQARAEEDAQRFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQR- 2438
Query: 711 RMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEK 770
Q+ + + ++A+A E R KE L++E +Q E + + V + + E
Sbjct: 2439 --QQSDHDAERLREAIA-----ELEREKEKLQQEAKLLQLKSEEM---QTVQQEQLLQET 2488
Query: 771 RKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLE---NRL 827
+ +++ SEK + E + Q+K E E KA++ E+++++ Q +E RL
Sbjct: 2489 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2548
Query: 828 TKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTK 887
EE ++ + + + + L +E+ Q+ + E L E+ L+ L E E +
Sbjct: 2549 VASMEEARRRQHEAEEGVRRKQEELQQLEQ-QRRQQEELLAEENQRLREQLQLLE-EQHR 2606
Query: 888 TKMIMVEERLILQQKMVKALQDEQES---------QRHGFEEEIMEYKEQIKQHAQTIVS 938
+ EE Q K L + +++ H F+ + Q Q A I+S
Sbjct: 2607 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILS 2665
Query: 939 LEEKLQKVTQHHKKIEGEIATLKD 962
EE LQ++ Q H ++ E+A +D
Sbjct: 2666 AEE-LQRLAQGHTTVD-ELARRED 2687
Score = 95.5 bits (236), Expect = 3e-19
Identities = 155/790 (19%), Positives = 332/790 (42%), Gaps = 111/790 (14%)
Query: 696 QERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQE----- 750
+E A++ EER+R+ E+E+ L +Q++ LA++ Q K + + +E Q R+QE
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 751 -------------LEERLARQKEVLESSIAHEKRKAKEA------LESEKRKVQDLENHL 791
++E L + ++ E+ I + R+A+ A +E E R V+
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 792 TQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQ-KEELELKEQKEDVLNNKL-S 849
+Q+ +E + + +A+EA E +K++ Q+ RL +Q ++E + K Q E L +++ +
Sbjct: 1465 ERQRGGAEGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1523
Query: 850 DALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQD 909
+A A E+ + +A E L+ ++ + AE+E + + +E ++ +
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-------TAQRSAEA 1576
Query: 910 EQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIE--------------- 954
E +S+R F E+ + + +++ + L E+ ++ Q + E
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1636
Query: 955 ------------GEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQK 1002
E+A K A E++ ++ E+ + A E + A++
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQ 1692
Query: 1003 EILSQQEVIMKLRKDLTEAHSRMSDLRGEL--NEKQKMELEQNVVLVQQQSKELSVLKEK 1060
E+ Q+++ + A + LR E E+Q+ LE+ + +Q +E + +K
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ---REAAAATQK 1749
Query: 1061 MAQMSSLVEKKDRELKAL-------EEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQ 1113
++ + + K E++ L EE R++ EK + +L E + + + + + +
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL----EAEAGRFRELAEEAAR 1805
Query: 1114 IEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHK 1173
+ + EA + Q+ ++ + + E V+ + A+ E E E A K
Sbjct: 1806 LRALAEEA----KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK--EK 1859
Query: 1174 DHQNESFLDL------KNLRMENNVQKILLDAKPDLPTLSRI--EILAPQNGLCNARFGS 1225
+ +NE L + R+E + D + L L + L Q GL
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1919
Query: 1226 AMEKSGKMDVAEA-LELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQ 1284
+ ++ +A E + ++ LG + + N + K + E + QL
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRS--NAEDTLRSKEQAELEAARQRQLAA 1977
Query: 1285 RDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDD------ 1338
+ + +++ L +EE R + +E++ R K +E + + E +
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037
Query: 1339 IYKEAEEKALLKE------ALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLR 1392
+ +EA +K L E A+++ E +L Q + +++ Q G +A+ + +E E R
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
Query: 1393 KETSSKSSQS 1402
+ +++QS
Sbjct: 2098 VQAEREAAQS 2107
Score = 94.0 bits (232), Expect = 9e-19
Identities = 244/1173 (20%), Positives = 470/1173 (40%), Gaps = 195/1173 (16%)
Query: 278 EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGEN 337
+KE +++C + Q E++ L ++ L KVL L E + +L++E E
Sbjct: 1012 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA--LPEPSPAAPTLRSELEL 1069
Query: 338 LKRDNAITSGMVSSLQKDILAKDEQVQQLK----EEVSHLKSQNKDKDHQLEALGSRCSV 393
L K EQV+ L E++ + + E L +
Sbjct: 1070 T------------------LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1111
Query: 394 LKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREK 453
LKE EL EA + LK + Q + + LR ELR + + + E+
Sbjct: 1112 LKEAQAVPATLPEL-EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1170
Query: 454 SKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQV------IKATYGRA 507
E+ +E + L + Q + + V + LE+ QL ++R ++ R
Sbjct: 1171 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1230
Query: 508 KPFRDKPVTDQQLI-EKITQ---VTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLR 563
+ + P+ D Q + E++ Q + E+ +K Q+ + + ++ + +
Sbjct: 1231 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1290
Query: 564 TSLDSCQACMK---ISCCSHDLKKE-VDLLQHL-QVSPPVSGLQKVVLDVLRHALSWLEE 618
L+ + K + S + +E VDL H +++ S K + + LR +EE
Sbjct: 1291 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR----MEE 1346
Query: 619 VEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQN 678
E+L QQ + +AA E + + EA A+ +AQ++
Sbjct: 1347 EERLAE--------------QQRAEERERLAEVEAA----LEKQRQLAEAHAQAKAQAER 1388
Query: 679 QATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVK 738
+A +E + ++E + + A + +++R +EL QQ + +++ Q K R
Sbjct: 1389 EA---KELQQRMQEEVVRREEAAVDAQQQKRSIQEEL-----QQLRQSSEAEIQAKARQA 1440
Query: 739 EALE------EEQTRVQELE-ERLARQKEVLESSIAH----------EKRKAKEALESEK 781
EA E EE+ RV L+ E RQ+ E + +KR+A+E E +
Sbjct: 1441 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1500
Query: 782 RKVQDLENHLTQQKEI-------SESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEEL 834
R+VQD E+ +Q E+ +E+ A EK++A +A+E+ + + ++ E RL ++ E+
Sbjct: 1501 RQVQD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL--RQAEV 1557
Query: 835 ELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVE 894
E Q + L A A E Q +A+ + K L L E + + V
Sbjct: 1558 ERARQVQVALETAQRSAEA---ELQSKRASFAEKTAQLERSLQE----------EHVAVA 1604
Query: 895 ERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIE 954
+ L+++ + Q + E++R E E + Q+K A + L + ++V Q +
Sbjct: 1605 Q---LREEAERRAQQQAEAERAREEAERELERWQLK--ANEALRLRLQAEEVAQQKSLAQ 1659
Query: 955 GEIATLKDNDPAPKEERPQ---DPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVI 1011
E K + A +E R + + E + +++ + + + A Q+ L+ ++ +
Sbjct: 1660 AEAE--KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR--LAAEQEL 1715
Query: 1012 MKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSV-LKEKMAQMSSLVEK 1070
++LR A + + + +L E++ L++ Q+ +EL L + A+M L+
Sbjct: 1716 IRLR-----AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Query: 1071 KDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQS 1130
K R EE R++ EK + +L E + + + + ++ + EA + Q+
Sbjct: 1771 KARA----EEESRSTSEKSKQRLEAEAG----RFRELAEEAARLRALAEEA----KRQRQ 1818
Query: 1131 FSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMEN 1190
++ + + E V+ + A+ E E E A K+ +NE L+ L +
Sbjct: 1819 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK--EKEAENER---LRRLAEDE 1873
Query: 1191 NVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMS 1250
Q+ R+E A Q+ K D+ E L K
Sbjct: 1874 AFQR------------RRLEEQAAQH---------------KADIEERLAQLRK------ 1900
Query: 1251 KTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRG 1310
S ++ G V R++ E+ + + +L+ +LGR
Sbjct: 1901 ---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR------- 1950
Query: 1311 YEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAI 1370
+ E RSK E+ ++ +L AEE+ +EA ER++ L E+ R
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLA------AEEERRRREAEERVQKSLAAEEEAARQR 2004
Query: 1371 RQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
+ + K+++ R LR+ +S++ L
Sbjct: 2005 KAALEEVERLKAKVEEARR-LRERAEQESARQL 2036
Score = 70.5 bits (171), Expect = 1e-11
Identities = 159/756 (21%), Positives = 301/756 (39%), Gaps = 103/756 (13%)
Query: 684 REGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEE 743
RE G Y Q+ ++ E +E R Q S L + L T+ +R++ L++
Sbjct: 956 REYGSCSHHY--QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1013
Query: 744 EQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHL--TQQKEISESN 801
E R E +R+A Q++ K A+ + E+EK + T + E+ +
Sbjct: 1014 EPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1071
Query: 802 IAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKT 861
E+ ++ A+ EK K L R T+ EE+ L+ +E + +E Q
Sbjct: 1072 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQL------------KEAQAV 1118
Query: 862 KATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDE----QE----- 912
AT L ELE TK + + + QQ AL+DE QE
Sbjct: 1119 PAT---------------LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1163
Query: 913 SQRHGFEE-EIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEER 971
QRHG + E+ ++E++ Q L E+ Q V + E+ L +E
Sbjct: 1164 QQRHGERDVEVERWRERVAQ-------LLERWQAVLAQTDVRQRELEQLGRQLRYYRES- 1215
Query: 972 PQDPLVAPMTESSAKDMAYEHL-IDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRG 1030
DPL A + ++ + + + + D A ++++ +Q ++ ++ + + +
Sbjct: 1216 -ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1274
Query: 1031 ELNEKQKMELEQNVVLVQ------------QQSKELSVLKEKM---AQMSSLVEKKDREL 1075
+N + EL+ Q QS SV++E + S L + +
Sbjct: 1275 YINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1334
Query: 1076 KALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLG 1135
K + E LR +E+ RL E++ R Q + A + +Q ++ +L
Sbjct: 1335 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1394
Query: 1136 VRCKGSRHEEVIQRQKKAL---SELRARIKELEKARSPDHKDHQNES----FLDLKNLRM 1188
R + EEV++R++ A+ + R+ +EL++ R + Q ++ + LR+
Sbjct: 1395 QRMQ----EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450
Query: 1189 ENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLD 1248
E ++ + L ++E Q G G+ E AE E ++ +
Sbjct: 1451 EEEIRVVRL----------QLEATERQRG------GAEGELQALRARAEEAEAQKRQAQE 1494
Query: 1249 MSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELL 1308
++ L +++ S + R K R+ + +L+ Q E L
Sbjct: 1495 EAERL--RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL 1552
Query: 1309 RGYEKDVEQLRRSKVSIEMYQ-SQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRIN 1367
R + +VE+ R+ +V++E Q S A+L+ AE+ A L+ +L+ + Q +
Sbjct: 1553 R--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1610
Query: 1368 RAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
QQ+ +A + + ERE+ R + + + L
Sbjct: 1611 ERRAQQQAEAERA--REEAERELERWQLKANEALRL 1644
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 134 bits (336), Expect = 8e-31
Identities = 263/1257 (20%), Positives = 491/1257 (39%), Gaps = 167/1257 (13%)
Query: 218 EEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSR-- 275
EE LA+Q + E L + + L ++ A + E EL Q++ E R
Sbjct: 1315 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1374
Query: 276 ------QNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEIT 329
Q ++ I ++ Q L + +A EIQ+ Q A ++ ++ EI
Sbjct: 1375 AAVDAQQQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSRLRI--------EEEIR 1423
Query: 330 SLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEA--- 386
++ + E +R G + +L+ + Q +Q +EE L+ Q +D+ +
Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1483
Query: 387 -LGSRCSVLKEELKQED----AHRELR-EAQEKELKLCKTQIQDMEKEMKKLRAELRKSC 440
L SR E +++ A ELR +A+E E +L + +++ + L R +
Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543
Query: 441 TEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLE-HFRSQV 499
E + EK+ E+ ++ + QL+E R + + ERA + E
Sbjct: 1544 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1603
Query: 500 IKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENI 559
+KA + + V Q+ + + +++K ++E + +E+
Sbjct: 1604 LKANEALRLRLQAEEVAQQKSLAQ--------AEAEKQKEEAEREARRRGKAEEQAVRQR 1655
Query: 560 EKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEV 619
E L+ Q + L E +L++ L+ Q+ +L+ EE+
Sbjct: 1656 ELAEQELEK-QRQLAEGTAQQRLAAEQELIR-LRAETEQGEQQRQLLE---------EEL 1704
Query: 620 EQLLRDLGILPSSPN--KDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQ 677
+L R+ + ++ + V A KA +E+ + R EA
Sbjct: 1705 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1764
Query: 678 NQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALA---------- 727
+ + +AL E ++R A+E +R E E +LA++ A+
Sbjct: 1765 RELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIGEATRLKTEAE 1821
Query: 728 ---KSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKV 784
K E R++ E+E + + LEE+ A+ K +E +A ++ + LE +K V
Sbjct: 1822 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1881
Query: 785 QD-LENHLTQQKEISESNIAYEKRKA-KEAMEKEKKKVQDLENRLTKQKEELELKEQKED 842
+D L ++EI ++EK A K +E E +++ + KE+ EL+ ++
Sbjct: 1882 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ- 1940
Query: 843 VLNNKLSDALAMVEETQKTKATE----SLKAESLALKLNE-TLAELETTKTKMIMVEERL 897
LA EE ++ +A E SL AE A + + L E+E K K VEE
Sbjct: 1941 -------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK---VEEAR 1990
Query: 898 ILQQKMVKALQDEQESQRH---GFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHK--- 951
L+++ EQES R E + + K HA + E++LQ+ Q +
Sbjct: 1991 RLRERA------EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2044
Query: 952 -KIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEV 1010
++ GE + +E R Q A + ++ E L + Q
Sbjct: 2045 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA--ERLKQSAEEQAQARAQAQAA 2102
Query: 1011 IMKLRKDL-TEAHSRMSDLRGELNEKQ--KMELEQNVVLVQQQSKELSVLKEKMAQMSSL 1067
KLRK+ EA R + L +KQ E+E++ +Q ++ + +++++ +
Sbjct: 2103 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2162
Query: 1068 VEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQE 1127
+E+ D + L+E L+ +L E + R+++Q V E FS
Sbjct: 2163 LEETDHQKNLLDEELQ--------RLKAEATEAARQRSQ----------VEEELFS---- 2200
Query: 1128 QQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLR 1187
++ Q + LS+L+ARI+ +A KD+ + FL + +
Sbjct: 2201 -------------------VRVQMEELSKLKARIEAENRALILRDKDN-TQRFLQEEAEK 2240
Query: 1188 MENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALEL-SEKLY 1246
M+ V + +R+ LA ++ M K V EA L +E
Sbjct: 2241 MK-QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2299
Query: 1247 LDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQL----RQRDLDLVFD------KITQ 1296
L K L + M +E + + RQR L++ + ++ +
Sbjct: 2300 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2359
Query: 1297 LKNQLGRKEELLRGYEKDVEQ----LRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEA 1352
+ R EE + + K E+ L R++++ + + V LE + + L+EA
Sbjct: 2360 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2419
Query: 1353 LERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPS 1409
+ +E + +EK A K+ K+ ++E L +ET + QS L K S
Sbjct: 2420 IAELERE--KEKLQQEA----KLLQLKSEEMQTVQQEQLLQETQA-LQQSFLSEKDS 2469
Score = 129 bits (324), Expect = 2e-29
Identities = 242/1276 (18%), Positives = 500/1276 (39%), Gaps = 178/1276 (13%)
Query: 250 KDVIIANLQNEVAELSQK----VSETTTSRQNEKEISQKCQVLDEDID---AKQKEIQSL 302
+DV + + VA+L ++ +++T ++ +++ ++ + E D A ++ +
Sbjct: 1138 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1197
Query: 303 KSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQ 362
+ QI A+ S+ + + L + + + ++ GE ++ +++++ L
Sbjct: 1198 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1257
Query: 363 VQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQI 422
QL+ S K + SV++E + + EL + +K +
Sbjct: 1258 KAQLEPVASPAKKPKVQSGSE--------SVIQEYVDLRTHYSELTTLTSQYIKFISETL 1309
Query: 423 QDMEKEMK---KLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRES 479
+ ME+E + + RAE R+ E R+ ++ + + + R+ +LQ+ E
Sbjct: 1310 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1369
Query: 480 V-----------IKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKI---T 525
V K +++ + QL I+A +A+ + ++ I +
Sbjct: 1370 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1429
Query: 526 QVTE-DNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSL-DSCQACMKISCCSHDLK 583
+ TE + + L+ + + +++ + E E+LR + D Q +
Sbjct: 1430 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---------RKRQ 1480
Query: 584 KEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSG 643
EV+L ++ + ++ L L EE E+ LR + QVQ
Sbjct: 1481 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV----ERARQVQ---- 1532
Query: 644 NSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQ--ERNRA 701
A+ TA ++A A + A E A+ E Q + + + E Q E RA
Sbjct: 1533 -VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1591
Query: 702 KETLEEERKRMQ-----ELESLLAQQKKALAKSITQ-EKNRVKEALEEEQTRVQELEERL 755
+E E E +R Q L L ++ A KS+ Q E + KE E E R + EE+
Sbjct: 1592 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1651
Query: 756 ARQKEVLESSIAHEKRKA------KEALESEKRKVQDLENHLTQQKEISESNIAYEKRKA 809
RQ+E+ E + +++ A + A E E +++ QQ+++ E +A +R+A
Sbjct: 1652 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1711
Query: 810 KEAMEKEKKKVQDL-------------------ENRLT--KQKEELELKEQKEDVLNNKL 848
A +K ++ +L E+R T K K+ LE + + L +
Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1771
Query: 849 SDALAMVEETQKTK-------ATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQ 901
+ A+ EE ++ + A + +AE + + + E KT+ + + +
Sbjct: 1772 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1831
Query: 902 KMVKALQDEQESQRHGFEEEIMEYKEQI-----------------------------KQH 932
+ ++ L +++ QR EE+ ++K I +Q
Sbjct: 1832 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1891
Query: 933 AQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAP-----MTESSAKD 987
+ I++L+ +K ++E E+ ++ N + Q L A E +
Sbjct: 1892 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1951
Query: 988 MAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLV 1047
E + LAA++E Q++ + +++ +++ + R L E+ + E + + L
Sbjct: 1952 REAEERVQKSLAAEEEAARQRKAAL---EEVERLKAKVEEAR-RLRERAEQESARQLQLA 2007
Query: 1048 QQQSKELSVLKEKMAQMSSLVEKKDREL-------KALEEALRASQEKHRLQLNTEKEQK 1100
Q+ +++ +EK + V++K++EL +++ + LR E R +E +
Sbjct: 2008 QEAAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2065
Query: 1101 PRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRA- 1159
+ + + + Q+E S+ ++ Q+ + + R E + ++A +E A
Sbjct: 2066 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2125
Query: 1160 RIKELEKARSPDHKDHQNESF-------LDLKNLRM---ENNVQKILLDAKPDLPTLSRI 1209
R K+ A HK ++ +L LR+ E + QK LLD +
Sbjct: 2126 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2185
Query: 1210 EILAPQNGLCNARFG--SAMEKSGKMDVAEALELSEKLYLDMSKTLGSLM----NIKNMS 1263
E ++ + F ME+ K+ E + D T L +K ++
Sbjct: 2186 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2245
Query: 1264 GHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKV 1323
+ ++ QE ++ QL + D L Q E++L+ + V++ R K
Sbjct: 2246 EEAARLSVAAQEAARLRQLAEED----------LAQQRALAEKMLKEKMQAVQEATRLKA 2295
Query: 1324 SIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLK 1383
E+ Q Q + E+ L+E E+M QL +E + ++ R+ L+
Sbjct: 2296 EAELLQQQKELAQ-------EQARRLQEDKEQMAQQLAEE---TQGFQRTLEAERQRQLE 2345
Query: 1384 MDQEREMLRKETSSKS 1399
M E E L+ + S
Sbjct: 2346 MSAEAERLKLRVAEMS 2361
Score = 116 bits (290), Expect = 2e-25
Identities = 189/955 (19%), Positives = 410/955 (42%), Gaps = 92/955 (9%)
Query: 240 LSDYEIESKYKDVIIANLQNEVA---ELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQ 296
L++ E+E K + + Q +A EL + +ET Q + + ++ L + A
Sbjct: 1657 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1715
Query: 297 KEIQSLKSQISALQKGY-----SKVLCQTLSERNSEITSLKNEGE-----NLKRDNAITS 346
++ Q L+++++ ++ SK + S SE + + E E L + A
Sbjct: 1716 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1775
Query: 347 GMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSV-LKEELKQEDAHR 405
+ ++ +E + + E + ++ + L + + LKE+ + + R
Sbjct: 1776 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1835
Query: 406 ELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCT-----EQSVISRTLREKSKVEEK- 459
L E + + + + Q + ++++ A+LRK+ ++ ++ TLR++ +VEE+
Sbjct: 1836 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1895
Query: 460 --LQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTD 517
L+ + E+ I+ N E + E + + A+ R + +
Sbjct: 1896 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1955
Query: 518 QQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETT-------ENIEKLRTSLDSCQ 570
+++ + + E +Q+K L++ +L +E E+ +L+ + ++ Q
Sbjct: 1956 ERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2012
Query: 571 ACMKISCCSHDL---KKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVE-QLLRDL 626
++ +H +KE +L Q LQ V + + R A EE Q R+
Sbjct: 2013 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2072
Query: 627 GILPSSPNK-DQVQQFSGNSAVFTAGKAAGASGREGEAERGEAR---ARGEAQSQNQATD 682
+ ++++Q + A A A A EAE+ AR A A Q QA D
Sbjct: 2073 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2132
Query: 683 GR-EGGKALEEYITQERNRAKETLEEERKRMQELE---SLL---AQQKKALAKSITQEKN 735
E K E +++ + ++ L R +++E + +LL Q+ KA A ++++
Sbjct: 2133 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2192
Query: 736 RVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQ- 794
+V+E L + +++EL + AR + + I +K + L+ E K++ + +
Sbjct: 2193 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2252
Query: 795 ---------KEISESNIAYEKRKAKEAMEKEKKKVQDL-----ENRLTKQKEELELKEQK 840
++++E ++A ++ A++ ++++ + VQ+ E L +Q++EL +EQ
Sbjct: 2253 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA-QEQA 2311
Query: 841 EDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQ 900
+ +K A + EETQ + T L+AE + E AE E K ++ +
Sbjct: 2312 RRLQEDKEQMAQQLAEETQGFQRT--LEAERQ--RQLEMSAEAERLKLRVAE------MS 2361
Query: 901 QKMVKALQDEQESQRHGFE-EEIMEYKEQIKQHAQTIV-SLEEKLQKVTQHHKKIEGEIA 958
+ +A +D Q ++ E E + E Q T+V +LE + Q+ +++ IA
Sbjct: 2362 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2421
Query: 959 TLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDL 1018
L+ KE+ Q+ + + + + E L+ + A Q+ LS+++ +++ + +
Sbjct: 2422 ELERE----KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2477
Query: 1019 TEAHSRMSDL-------RGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKK 1071
+ +++ L +L E+Q+ + +Q Q+ + + + + V +K
Sbjct: 2478 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2537
Query: 1072 DRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQ 1126
EL+ LE+ R +E L E+ Q+ R++ Q + + H+E ++SQ
Sbjct: 2538 QEELQQLEQQRRQQEE-----LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2587
Score = 105 bits (261), Expect = 4e-22
Identities = 171/744 (22%), Positives = 307/744 (41%), Gaps = 107/744 (14%)
Query: 260 EVAELSQKVSETTTSRQN-EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLC 318
EV L KV E R+ E+E +++ Q+ E A QK +Q+ + + + + L
Sbjct: 1978 EVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQKRLQAEEKAHAFAVQQKEQELQ 2034
Query: 319 QTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNK 378
QTL + S + L+ E E +R ++ + + + Q + +V + +
Sbjct: 2035 QTLQQEQSVLDQLRGEAEAARR-------AAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2087
Query: 379 DKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRK 438
+ Q +A ++ E+L++E R AQ ++ L + Q D E E K AE
Sbjct: 2088 SAEEQAQAR-AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--- 2143
Query: 439 SCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHF--- 495
+TLR+K++VE++L LQL+E ++++++ L+R +
Sbjct: 2144 ---------QTLRQKAQVEQELTT----LRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2190
Query: 496 RSQVIKATYG-------------------RAKPFRDKPVTD---QQLIEKITQVTEDNIN 533
RSQV + + RA RDK T Q+ EK+ QV E+
Sbjct: 2191 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2250
Query: 534 FQQKKWTLQKETQLSNSKQEETTENIEK-LRTSLDSCQACMKISCCSHDLKKEVDLLQHL 592
+ QL+ + EK L+ + + Q + LK E +LLQ
Sbjct: 2251 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQ- 2302
Query: 593 QVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGK 652
QK + L E+ EQ+ + L + + + + + +
Sbjct: 2303 ---------QKELAQEQARRLQ--EDKEQMAQQLA--EETQGFQRTLEAERQRQLEMSAE 2349
Query: 653 AAGASGREGEAERGEARARGEAQSQNQATDGREGGKALE--EYITQERNRAKETLEEERK 710
A R E R +ARA +AQ + + E G+ L E TQE+ +TLE +R
Sbjct: 2350 AERLKLRVAEMSRAQARAEEDAQRFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQR- 2406
Query: 711 RMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEK 770
Q+ + + ++A+A E R KE L++E +Q E + + V + + E
Sbjct: 2407 --QQSDHDAERLREAIA-----ELEREKEKLQQEAKLLQLKSEEM---QTVQQEQLLQET 2456
Query: 771 RKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLE---NRL 827
+ +++ SEK + E + Q+K E E KA++ E+++++ Q +E RL
Sbjct: 2457 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2516
Query: 828 TKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTK 887
EE ++ + + + + L +E+ Q+ + E L E+ L+ L E E +
Sbjct: 2517 VASMEEARRRQHEAEEGVRRKQEELQQLEQ-QRRQQEELLAEENQRLREQLQLLE-EQHR 2574
Query: 888 TKMIMVEERLILQQKMVKALQDEQES---------QRHGFEEEIMEYKEQIKQHAQTIVS 938
+ EE Q K L + +++ H F+ + Q Q A I+S
Sbjct: 2575 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILS 2633
Query: 939 LEEKLQKVTQHHKKIEGEIATLKD 962
EE LQ++ Q H ++ E+A +D
Sbjct: 2634 AEE-LQRLAQGHTTVD-ELARRED 2655
Score = 95.5 bits (236), Expect = 3e-19
Identities = 155/790 (19%), Positives = 332/790 (42%), Gaps = 111/790 (14%)
Query: 696 QERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQE----- 750
+E A++ EER+R+ E+E+ L +Q++ LA++ Q K + + +E Q R+QE
Sbjct: 1314 EEERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQRMQEEVVRR 1372
Query: 751 -------------LEERLARQKEVLESSIAHEKRKAKEA------LESEKRKVQDLENHL 791
++E L + ++ E+ I + R+A+ A +E E R V+
Sbjct: 1373 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1432
Query: 792 TQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQ-KEELELKEQKEDVLNNKL-S 849
+Q+ +E + + +A+EA E +K++ Q+ RL +Q ++E + K Q E L +++ +
Sbjct: 1433 ERQRGGAEGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1491
Query: 850 DALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQD 909
+A A E+ + +A E L+ ++ + AE+E + + +E ++ +
Sbjct: 1492 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-------TAQRSAEA 1544
Query: 910 EQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIE--------------- 954
E +S+R F E+ + + +++ + L E+ ++ Q + E
Sbjct: 1545 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1604
Query: 955 ------------GEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQK 1002
E+A K A E++ ++ E+ + A E + A++
Sbjct: 1605 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQ 1660
Query: 1003 EILSQQEVIMKLRKDLTEAHSRMSDLRGEL--NEKQKMELEQNVVLVQQQSKELSVLKEK 1060
E+ Q+++ + A + LR E E+Q+ LE+ + +Q +E + +K
Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ---REAAAATQK 1717
Query: 1061 MAQMSSLVEKKDRELKAL-------EEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQ 1113
++ + + K E++ L EE R++ EK + +L E + + + + + +
Sbjct: 1718 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL----EAEAGRFRELAEEAAR 1773
Query: 1114 IEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHK 1173
+ + EA + Q+ ++ + + E V+ + A+ E E E A K
Sbjct: 1774 LRALAEEA----KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK--EK 1827
Query: 1174 DHQNESFLDL------KNLRMENNVQKILLDAKPDLPTLSRI--EILAPQNGLCNARFGS 1225
+ +NE L + R+E + D + L L + L Q GL
Sbjct: 1828 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1887
Query: 1226 AMEKSGKMDVAEA-LELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQ 1284
+ ++ +A E + ++ LG + + N + K + E + QL
Sbjct: 1888 RRQVEEEILALKASFEKAAAGKAELELELGRIRS--NAEDTLRSKEQAELEAARQRQLAA 1945
Query: 1285 RDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDD------ 1338
+ + +++ L +EE R + +E++ R K +E + + E +
Sbjct: 1946 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2005
Query: 1339 IYKEAEEKALLKE------ALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLR 1392
+ +EA +K L E A+++ E +L Q + +++ Q G +A+ + +E E R
Sbjct: 2006 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2065
Query: 1393 KETSSKSSQS 1402
+ +++QS
Sbjct: 2066 VQAEREAAQS 2075
Score = 94.0 bits (232), Expect = 9e-19
Identities = 244/1173 (20%), Positives = 470/1173 (40%), Gaps = 195/1173 (16%)
Query: 278 EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGEN 337
+KE +++C + Q E++ L ++ L KVL L E + +L++E E
Sbjct: 980 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA--LPEPSPAAPTLRSELEL 1037
Query: 338 LKRDNAITSGMVSSLQKDILAKDEQVQQLK----EEVSHLKSQNKDKDHQLEALGSRCSV 393
L K EQV+ L E++ + + E L +
Sbjct: 1038 T------------------LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1079
Query: 394 LKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREK 453
LKE EL EA + LK + Q + + LR ELR + + + E+
Sbjct: 1080 LKEAQAVPATLPEL-EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1138
Query: 454 SKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQV------IKATYGRA 507
E+ +E + L + Q + + V + LE+ QL ++R ++ R
Sbjct: 1139 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1198
Query: 508 KPFRDKPVTDQQLI-EKITQ---VTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLR 563
+ + P+ D Q + E++ Q + E+ +K Q+ + + ++ + +
Sbjct: 1199 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1258
Query: 564 TSLDSCQACMK---ISCCSHDLKKE-VDLLQHL-QVSPPVSGLQKVVLDVLRHALSWLEE 618
L+ + K + S + +E VDL H +++ S K + + LR +EE
Sbjct: 1259 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR----MEE 1314
Query: 619 VEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQN 678
E+L QQ + +AA E + + EA A+ +AQ++
Sbjct: 1315 EERLAE--------------QQRAEERERLAEVEAA----LEKQRQLAEAHAQAKAQAER 1356
Query: 679 QATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVK 738
+A +E + ++E + + A + +++R +EL QQ + +++ Q K R
Sbjct: 1357 EA---KELQQRMQEEVVRREEAAVDAQQQKRSIQEEL-----QQLRQSSEAEIQAKARQA 1408
Query: 739 EALE------EEQTRVQELE-ERLARQKEVLESSIAH----------EKRKAKEALESEK 781
EA E EE+ RV L+ E RQ+ E + +KR+A+E E +
Sbjct: 1409 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1468
Query: 782 RKVQDLENHLTQQKEI-------SESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEEL 834
R+VQD E+ +Q E+ +E+ A EK++A +A+E+ + + ++ E RL ++ E+
Sbjct: 1469 RQVQD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL--RQAEV 1525
Query: 835 ELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVE 894
E Q + L A A E Q +A+ + K L L E + + V
Sbjct: 1526 ERARQVQVALETAQRSAEA---ELQSKRASFAEKTAQLERSLQE----------EHVAVA 1572
Query: 895 ERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIE 954
+ L+++ + Q + E++R E E + Q+K A + L + ++V Q +
Sbjct: 1573 Q---LREEAERRAQQQAEAERAREEAERELERWQLK--ANEALRLRLQAEEVAQQKSLAQ 1627
Query: 955 GEIATLKDNDPAPKEERPQ---DPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVI 1011
E K + A +E R + + E + +++ + + + A Q+ L+ ++ +
Sbjct: 1628 AEAE--KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR--LAAEQEL 1683
Query: 1012 MKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSV-LKEKMAQMSSLVEK 1070
++LR A + + + +L E++ L++ Q+ +EL L + A+M L+
Sbjct: 1684 IRLR-----AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1738
Query: 1071 KDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQS 1130
K R EE R++ EK + +L E + + + + ++ + EA + Q+
Sbjct: 1739 KARA----EEESRSTSEKSKQRLEAEAG----RFRELAEEAARLRALAEEA----KRQRQ 1786
Query: 1131 FSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMEN 1190
++ + + E V+ + A+ E E E A K+ +NE L+ L +
Sbjct: 1787 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK--EKEAENER---LRRLAEDE 1841
Query: 1191 NVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMS 1250
Q+ R+E A Q+ K D+ E L K
Sbjct: 1842 AFQR------------RRLEEQAAQH---------------KADIEERLAQLRK------ 1868
Query: 1251 KTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRG 1310
S ++ G V R++ E+ + + +L+ +LGR
Sbjct: 1869 ---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR------- 1918
Query: 1311 YEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAI 1370
+ E RSK E+ ++ +L AEE+ +EA ER++ L E+ R
Sbjct: 1919 IRSNAEDTLRSKEQAELEAARQRQLA------AEEERRRREAEERVQKSLAAEEEAARQR 1972
Query: 1371 RQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
+ + K+++ R LR+ +S++ L
Sbjct: 1973 KAALEEVERLKAKVEEARR-LRERAEQESARQL 2004
Score = 70.5 bits (171), Expect = 1e-11
Identities = 159/756 (21%), Positives = 301/756 (39%), Gaps = 103/756 (13%)
Query: 684 REGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEE 743
RE G Y Q+ ++ E +E R Q S L + L T+ +R++ L++
Sbjct: 924 REYGSCSHHY--QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 981
Query: 744 EQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHL--TQQKEISESN 801
E R E +R+A Q++ K A+ + E+EK + T + E+ +
Sbjct: 982 EPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1039
Query: 802 IAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKT 861
E+ ++ A+ EK K L R T+ EE+ L+ +E + +E Q
Sbjct: 1040 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQL------------KEAQAV 1086
Query: 862 KATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDE----QE----- 912
AT L ELE TK + + + QQ AL+DE QE
Sbjct: 1087 PAT---------------LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1131
Query: 913 SQRHGFEE-EIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEER 971
QRHG + E+ ++E++ Q L E+ Q V + E+ L +E
Sbjct: 1132 QQRHGERDVEVERWRERVAQ-------LLERWQAVLAQTDVRQRELEQLGRQLRYYRES- 1183
Query: 972 PQDPLVAPMTESSAKDMAYEHL-IDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRG 1030
DPL A + ++ + + + + D A ++++ +Q ++ ++ + + +
Sbjct: 1184 -ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1242
Query: 1031 ELNEKQKMELEQNVVLVQ------------QQSKELSVLKEKM---AQMSSLVEKKDREL 1075
+N + EL+ Q QS SV++E + S L + +
Sbjct: 1243 YINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1302
Query: 1076 KALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLG 1135
K + E LR +E+ RL E++ R Q + A + +Q ++ +L
Sbjct: 1303 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1362
Query: 1136 VRCKGSRHEEVIQRQKKAL---SELRARIKELEKARSPDHKDHQNES----FLDLKNLRM 1188
R + EEV++R++ A+ + R+ +EL++ R + Q ++ + LR+
Sbjct: 1363 QRMQ----EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1418
Query: 1189 ENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLD 1248
E ++ + L ++E Q G G+ E AE E ++ +
Sbjct: 1419 EEEIRVVRL----------QLEATERQRG------GAEGELQALRARAEEAEAQKRQAQE 1462
Query: 1249 MSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELL 1308
++ L +++ S + R K R+ + +L+ Q E L
Sbjct: 1463 EAERL--RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL 1520
Query: 1309 RGYEKDVEQLRRSKVSIEMYQ-SQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRIN 1367
R + +VE+ R+ +V++E Q S A+L+ AE+ A L+ +L+ + Q +
Sbjct: 1521 R--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1578
Query: 1368 RAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
QQ+ +A + + ERE+ R + + + L
Sbjct: 1579 ERRAQQQAEAERA--REEAERELERWQLKANEALRL 1612
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 134 bits (336), Expect = 8e-31
Identities = 263/1257 (20%), Positives = 491/1257 (39%), Gaps = 167/1257 (13%)
Query: 218 EEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSR-- 275
EE LA+Q + E L + + L ++ A + E EL Q++ E R
Sbjct: 1484 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1543
Query: 276 ------QNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEIT 329
Q ++ I ++ Q L + +A EIQ+ Q A ++ ++ EI
Sbjct: 1544 AAVDAQQQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSRLRI--------EEEIR 1592
Query: 330 SLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEA--- 386
++ + E +R G + +L+ + Q +Q +EE L+ Q +D+ +
Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1652
Query: 387 -LGSRCSVLKEELKQED----AHRELR-EAQEKELKLCKTQIQDMEKEMKKLRAELRKSC 440
L SR E +++ A ELR +A+E E +L + +++ + L R +
Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712
Query: 441 TEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLE-HFRSQV 499
E + EK+ E+ ++ + QL+E R + + ERA + E
Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1772
Query: 500 IKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENI 559
+KA + + V Q+ + + +++K ++E + +E+
Sbjct: 1773 LKANEALRLRLQAEEVAQQKSLAQ--------AEAEKQKEEAEREARRRGKAEEQAVRQR 1824
Query: 560 EKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEV 619
E L+ Q + L E +L++ L+ Q+ +L+ EE+
Sbjct: 1825 ELAEQELEK-QRQLAEGTAQQRLAAEQELIR-LRAETEQGEQQRQLLE---------EEL 1873
Query: 620 EQLLRDLGILPSSPN--KDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQ 677
+L R+ + ++ + V A KA +E+ + R EA
Sbjct: 1874 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1933
Query: 678 NQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALA---------- 727
+ + +AL E ++R A+E +R E E +LA++ A+
Sbjct: 1934 RELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIGEATRLKTEAE 1990
Query: 728 ---KSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKV 784
K E R++ E+E + + LEE+ A+ K +E +A ++ + LE +K V
Sbjct: 1991 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 2050
Query: 785 QD-LENHLTQQKEISESNIAYEKRKA-KEAMEKEKKKVQDLENRLTKQKEELELKEQKED 842
+D L ++EI ++EK A K +E E +++ + KE+ EL+ ++
Sbjct: 2051 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ- 2109
Query: 843 VLNNKLSDALAMVEETQKTKATE----SLKAESLALKLNE-TLAELETTKTKMIMVEERL 897
LA EE ++ +A E SL AE A + + L E+E K K VEE
Sbjct: 2110 -------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK---VEEAR 2159
Query: 898 ILQQKMVKALQDEQESQRH---GFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHK--- 951
L+++ EQES R E + + K HA + E++LQ+ Q +
Sbjct: 2160 RLRERA------EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2213
Query: 952 -KIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEV 1010
++ GE + +E R Q A + ++ E L + Q
Sbjct: 2214 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA--ERLKQSAEEQAQARAQAQAA 2271
Query: 1011 IMKLRKDL-TEAHSRMSDLRGELNEKQ--KMELEQNVVLVQQQSKELSVLKEKMAQMSSL 1067
KLRK+ EA R + L +KQ E+E++ +Q ++ + +++++ +
Sbjct: 2272 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2331
Query: 1068 VEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQE 1127
+E+ D + L+E L+ +L E + R+++Q V E FS
Sbjct: 2332 LEETDHQKNLLDEELQ--------RLKAEATEAARQRSQ----------VEEELFS---- 2369
Query: 1128 QQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLR 1187
++ Q + LS+L+ARI+ +A KD+ + FL + +
Sbjct: 2370 -------------------VRVQMEELSKLKARIEAENRALILRDKDN-TQRFLQEEAEK 2409
Query: 1188 MENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALEL-SEKLY 1246
M+ V + +R+ LA ++ M K V EA L +E
Sbjct: 2410 MK-QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2468
Query: 1247 LDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQL----RQRDLDLVFD------KITQ 1296
L K L + M +E + + RQR L++ + ++ +
Sbjct: 2469 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2528
Query: 1297 LKNQLGRKEELLRGYEKDVEQ----LRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEA 1352
+ R EE + + K E+ L R++++ + + V LE + + L+EA
Sbjct: 2529 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2588
Query: 1353 LERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPS 1409
+ +E + +EK A K+ K+ ++E L +ET + QS L K S
Sbjct: 2589 IAELERE--KEKLQQEA----KLLQLKSEEMQTVQQEQLLQETQA-LQQSFLSEKDS 2638
Score = 129 bits (324), Expect = 2e-29
Identities = 242/1276 (18%), Positives = 500/1276 (39%), Gaps = 178/1276 (13%)
Query: 250 KDVIIANLQNEVAELSQK----VSETTTSRQNEKEISQKCQVLDEDID---AKQKEIQSL 302
+DV + + VA+L ++ +++T ++ +++ ++ + E D A ++ +
Sbjct: 1307 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1366
Query: 303 KSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQ 362
+ QI A+ S+ + + L + + + ++ GE ++ +++++ L
Sbjct: 1367 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1426
Query: 363 VQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQI 422
QL+ S K + SV++E + + EL + +K +
Sbjct: 1427 KAQLEPVASPAKKPKVQSGSE--------SVIQEYVDLRTHYSELTTLTSQYIKFISETL 1478
Query: 423 QDMEKEMK---KLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRES 479
+ ME+E + + RAE R+ E R+ ++ + + + R+ +LQ+ E
Sbjct: 1479 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1538
Query: 480 V-----------IKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKI---T 525
V K +++ + QL I+A +A+ + ++ I +
Sbjct: 1539 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1598
Query: 526 QVTE-DNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSL-DSCQACMKISCCSHDLK 583
+ TE + + L+ + + +++ + E E+LR + D Q +
Sbjct: 1599 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---------RKRQ 1649
Query: 584 KEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSG 643
EV+L ++ + ++ L L EE E+ LR + QVQ
Sbjct: 1650 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV----ERARQVQ---- 1701
Query: 644 NSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQ--ERNRA 701
A+ TA ++A A + A E A+ E Q + + + E Q E RA
Sbjct: 1702 -VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1760
Query: 702 KETLEEERKRMQ-----ELESLLAQQKKALAKSITQ-EKNRVKEALEEEQTRVQELEERL 755
+E E E +R Q L L ++ A KS+ Q E + KE E E R + EE+
Sbjct: 1761 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1820
Query: 756 ARQKEVLESSIAHEKRKA------KEALESEKRKVQDLENHLTQQKEISESNIAYEKRKA 809
RQ+E+ E + +++ A + A E E +++ QQ+++ E +A +R+A
Sbjct: 1821 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1880
Query: 810 KEAMEKEKKKVQDL-------------------ENRLT--KQKEELELKEQKEDVLNNKL 848
A +K ++ +L E+R T K K+ LE + + L +
Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1940
Query: 849 SDALAMVEETQKTK-------ATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQ 901
+ A+ EE ++ + A + +AE + + + E KT+ + + +
Sbjct: 1941 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 2000
Query: 902 KMVKALQDEQESQRHGFEEEIMEYKEQI-----------------------------KQH 932
+ ++ L +++ QR EE+ ++K I +Q
Sbjct: 2001 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 2060
Query: 933 AQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAP-----MTESSAKD 987
+ I++L+ +K ++E E+ ++ N + Q L A E +
Sbjct: 2061 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2120
Query: 988 MAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLV 1047
E + LAA++E Q++ + +++ +++ + R L E+ + E + + L
Sbjct: 2121 REAEERVQKSLAAEEEAARQRKAAL---EEVERLKAKVEEAR-RLRERAEQESARQLQLA 2176
Query: 1048 QQQSKELSVLKEKMAQMSSLVEKKDREL-------KALEEALRASQEKHRLQLNTEKEQK 1100
Q+ +++ +EK + V++K++EL +++ + LR E R +E +
Sbjct: 2177 QEAAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2234
Query: 1101 PRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRA- 1159
+ + + + Q+E S+ ++ Q+ + + R E + ++A +E A
Sbjct: 2235 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2294
Query: 1160 RIKELEKARSPDHKDHQNESF-------LDLKNLRM---ENNVQKILLDAKPDLPTLSRI 1209
R K+ A HK ++ +L LR+ E + QK LLD +
Sbjct: 2295 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2354
Query: 1210 EILAPQNGLCNARFG--SAMEKSGKMDVAEALELSEKLYLDMSKTLGSLM----NIKNMS 1263
E ++ + F ME+ K+ E + D T L +K ++
Sbjct: 2355 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2414
Query: 1264 GHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKV 1323
+ ++ QE ++ QL + D L Q E++L+ + V++ R K
Sbjct: 2415 EEAARLSVAAQEAARLRQLAEED----------LAQQRALAEKMLKEKMQAVQEATRLKA 2464
Query: 1324 SIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLK 1383
E+ Q Q + E+ L+E E+M QL +E + ++ R+ L+
Sbjct: 2465 EAELLQQQKELAQ-------EQARRLQEDKEQMAQQLAEE---TQGFQRTLEAERQRQLE 2514
Query: 1384 MDQEREMLRKETSSKS 1399
M E E L+ + S
Sbjct: 2515 MSAEAERLKLRVAEMS 2530
Score = 116 bits (290), Expect = 2e-25
Identities = 189/955 (19%), Positives = 410/955 (42%), Gaps = 92/955 (9%)
Query: 240 LSDYEIESKYKDVIIANLQNEVA---ELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQ 296
L++ E+E K + + Q +A EL + +ET Q + + ++ L + A
Sbjct: 1826 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1884
Query: 297 KEIQSLKSQISALQKGY-----SKVLCQTLSERNSEITSLKNEGE-----NLKRDNAITS 346
++ Q L+++++ ++ SK + S SE + + E E L + A
Sbjct: 1885 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1944
Query: 347 GMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSV-LKEELKQEDAHR 405
+ ++ +E + + E + ++ + L + + LKE+ + + R
Sbjct: 1945 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 2004
Query: 406 ELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCT-----EQSVISRTLREKSKVEEK- 459
L E + + + + Q + ++++ A+LRK+ ++ ++ TLR++ +VEE+
Sbjct: 2005 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 2064
Query: 460 --LQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTD 517
L+ + E+ I+ N E + E + + A+ R + +
Sbjct: 2065 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 2124
Query: 518 QQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETT-------ENIEKLRTSLDSCQ 570
+++ + + E +Q+K L++ +L +E E+ +L+ + ++ Q
Sbjct: 2125 ERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2181
Query: 571 ACMKISCCSHDL---KKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVE-QLLRDL 626
++ +H +KE +L Q LQ V + + R A EE Q R+
Sbjct: 2182 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2241
Query: 627 GILPSSPNK-DQVQQFSGNSAVFTAGKAAGASGREGEAERGEAR---ARGEAQSQNQATD 682
+ ++++Q + A A A A EAE+ AR A A Q QA D
Sbjct: 2242 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2301
Query: 683 GR-EGGKALEEYITQERNRAKETLEEERKRMQELE---SLL---AQQKKALAKSITQEKN 735
E K E +++ + ++ L R +++E + +LL Q+ KA A ++++
Sbjct: 2302 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2361
Query: 736 RVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQ- 794
+V+E L + +++EL + AR + + I +K + L+ E K++ + +
Sbjct: 2362 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2421
Query: 795 ---------KEISESNIAYEKRKAKEAMEKEKKKVQDL-----ENRLTKQKEELELKEQK 840
++++E ++A ++ A++ ++++ + VQ+ E L +Q++EL +EQ
Sbjct: 2422 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA-QEQA 2480
Query: 841 EDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQ 900
+ +K A + EETQ + T L+AE + E AE E K ++ +
Sbjct: 2481 RRLQEDKEQMAQQLAEETQGFQRT--LEAERQ--RQLEMSAEAERLKLRVAE------MS 2530
Query: 901 QKMVKALQDEQESQRHGFE-EEIMEYKEQIKQHAQTIV-SLEEKLQKVTQHHKKIEGEIA 958
+ +A +D Q ++ E E + E Q T+V +LE + Q+ +++ IA
Sbjct: 2531 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2590
Query: 959 TLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDL 1018
L+ KE+ Q+ + + + + E L+ + A Q+ LS+++ +++ + +
Sbjct: 2591 ELERE----KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2646
Query: 1019 TEAHSRMSDL-------RGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKK 1071
+ +++ L +L E+Q+ + +Q Q+ + + + + V +K
Sbjct: 2647 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2706
Query: 1072 DRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQ 1126
EL+ LE+ R +E L E+ Q+ R++ Q + + H+E ++SQ
Sbjct: 2707 QEELQQLEQQRRQQEE-----LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2756
Score = 105 bits (261), Expect = 4e-22
Identities = 171/744 (22%), Positives = 307/744 (41%), Gaps = 107/744 (14%)
Query: 260 EVAELSQKVSETTTSRQN-EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLC 318
EV L KV E R+ E+E +++ Q+ E A QK +Q+ + + + + L
Sbjct: 2147 EVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQKRLQAEEKAHAFAVQQKEQELQ 2203
Query: 319 QTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNK 378
QTL + S + L+ E E +R ++ + + + Q + +V + +
Sbjct: 2204 QTLQQEQSVLDQLRGEAEAARR-------AAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2256
Query: 379 DKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRK 438
+ Q +A ++ E+L++E R AQ ++ L + Q D E E K AE
Sbjct: 2257 SAEEQAQAR-AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--- 2312
Query: 439 SCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHF--- 495
+TLR+K++VE++L LQL+E ++++++ L+R +
Sbjct: 2313 ---------QTLRQKAQVEQELTT----LRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2359
Query: 496 RSQVIKATYG-------------------RAKPFRDKPVTD---QQLIEKITQVTEDNIN 533
RSQV + + RA RDK T Q+ EK+ QV E+
Sbjct: 2360 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2419
Query: 534 FQQKKWTLQKETQLSNSKQEETTENIEK-LRTSLDSCQACMKISCCSHDLKKEVDLLQHL 592
+ QL+ + EK L+ + + Q + LK E +LLQ
Sbjct: 2420 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQ- 2471
Query: 593 QVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGK 652
QK + L E+ EQ+ + L + + + + + +
Sbjct: 2472 ---------QKELAQEQARRLQ--EDKEQMAQQLA--EETQGFQRTLEAERQRQLEMSAE 2518
Query: 653 AAGASGREGEAERGEARARGEAQSQNQATDGREGGKALE--EYITQERNRAKETLEEERK 710
A R E R +ARA +AQ + + E G+ L E TQE+ +TLE +R
Sbjct: 2519 AERLKLRVAEMSRAQARAEEDAQRFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQR- 2575
Query: 711 RMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEK 770
Q+ + + ++A+A E R KE L++E +Q E + + V + + E
Sbjct: 2576 --QQSDHDAERLREAIA-----ELEREKEKLQQEAKLLQLKSEEM---QTVQQEQLLQET 2625
Query: 771 RKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLE---NRL 827
+ +++ SEK + E + Q+K E E KA++ E+++++ Q +E RL
Sbjct: 2626 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2685
Query: 828 TKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTK 887
EE ++ + + + + L +E+ Q+ + E L E+ L+ L E E +
Sbjct: 2686 VASMEEARRRQHEAEEGVRRKQEELQQLEQ-QRRQQEELLAEENQRLREQLQLLE-EQHR 2743
Query: 888 TKMIMVEERLILQQKMVKALQDEQES---------QRHGFEEEIMEYKEQIKQHAQTIVS 938
+ EE Q K L + +++ H F+ + Q Q A I+S
Sbjct: 2744 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILS 2802
Query: 939 LEEKLQKVTQHHKKIEGEIATLKD 962
EE LQ++ Q H ++ E+A +D
Sbjct: 2803 AEE-LQRLAQGHTTVD-ELARRED 2824
Score = 95.5 bits (236), Expect = 3e-19
Identities = 155/790 (19%), Positives = 332/790 (42%), Gaps = 111/790 (14%)
Query: 696 QERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQE----- 750
+E A++ EER+R+ E+E+ L +Q++ LA++ Q K + + +E Q R+QE
Sbjct: 1483 EEERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQRMQEEVVRR 1541
Query: 751 -------------LEERLARQKEVLESSIAHEKRKAKEA------LESEKRKVQDLENHL 791
++E L + ++ E+ I + R+A+ A +E E R V+
Sbjct: 1542 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1601
Query: 792 TQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQ-KEELELKEQKEDVLNNKL-S 849
+Q+ +E + + +A+EA E +K++ Q+ RL +Q ++E + K Q E L +++ +
Sbjct: 1602 ERQRGGAEGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1660
Query: 850 DALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQD 909
+A A E+ + +A E L+ ++ + AE+E + + +E ++ +
Sbjct: 1661 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-------TAQRSAEA 1713
Query: 910 EQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIE--------------- 954
E +S+R F E+ + + +++ + L E+ ++ Q + E
Sbjct: 1714 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1773
Query: 955 ------------GEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQK 1002
E+A K A E++ ++ E+ + A E + A++
Sbjct: 1774 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQ 1829
Query: 1003 EILSQQEVIMKLRKDLTEAHSRMSDLRGEL--NEKQKMELEQNVVLVQQQSKELSVLKEK 1060
E+ Q+++ + A + LR E E+Q+ LE+ + +Q +E + +K
Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ---REAAAATQK 1886
Query: 1061 MAQMSSLVEKKDRELKAL-------EEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQ 1113
++ + + K E++ L EE R++ EK + +L E + + + + + +
Sbjct: 1887 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL----EAEAGRFRELAEEAAR 1942
Query: 1114 IEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHK 1173
+ + EA + Q+ ++ + + E V+ + A+ E E E A K
Sbjct: 1943 LRALAEEA----KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK--EK 1996
Query: 1174 DHQNESFLDL------KNLRMENNVQKILLDAKPDLPTLSRI--EILAPQNGLCNARFGS 1225
+ +NE L + R+E + D + L L + L Q GL
Sbjct: 1997 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 2056
Query: 1226 AMEKSGKMDVAEA-LELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQ 1284
+ ++ +A E + ++ LG + + N + K + E + QL
Sbjct: 2057 RRQVEEEILALKASFEKAAAGKAELELELGRIRS--NAEDTLRSKEQAELEAARQRQLAA 2114
Query: 1285 RDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDD------ 1338
+ + +++ L +EE R + +E++ R K +E + + E +
Sbjct: 2115 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2174
Query: 1339 IYKEAEEKALLKE------ALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLR 1392
+ +EA +K L E A+++ E +L Q + +++ Q G +A+ + +E E R
Sbjct: 2175 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2234
Query: 1393 KETSSKSSQS 1402
+ +++QS
Sbjct: 2235 VQAEREAAQS 2244
Score = 94.0 bits (232), Expect = 9e-19
Identities = 244/1173 (20%), Positives = 470/1173 (40%), Gaps = 195/1173 (16%)
Query: 278 EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGEN 337
+KE +++C + Q E++ L ++ L KVL L E + +L++E E
Sbjct: 1149 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA--LPEPSPAAPTLRSELEL 1206
Query: 338 LKRDNAITSGMVSSLQKDILAKDEQVQQLK----EEVSHLKSQNKDKDHQLEALGSRCSV 393
L K EQV+ L E++ + + E L +
Sbjct: 1207 T------------------LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1248
Query: 394 LKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREK 453
LKE EL EA + LK + Q + + LR ELR + + + E+
Sbjct: 1249 LKEAQAVPATLPEL-EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1307
Query: 454 SKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQV------IKATYGRA 507
E+ +E + L + Q + + V + LE+ QL ++R ++ R
Sbjct: 1308 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1367
Query: 508 KPFRDKPVTDQQLI-EKITQ---VTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLR 563
+ + P+ D Q + E++ Q + E+ +K Q+ + + ++ + +
Sbjct: 1368 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1427
Query: 564 TSLDSCQACMK---ISCCSHDLKKE-VDLLQHL-QVSPPVSGLQKVVLDVLRHALSWLEE 618
L+ + K + S + +E VDL H +++ S K + + LR +EE
Sbjct: 1428 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR----MEE 1483
Query: 619 VEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQN 678
E+L QQ + +AA E + + EA A+ +AQ++
Sbjct: 1484 EERLAE--------------QQRAEERERLAEVEAA----LEKQRQLAEAHAQAKAQAER 1525
Query: 679 QATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVK 738
+A +E + ++E + + A + +++R +EL QQ + +++ Q K R
Sbjct: 1526 EA---KELQQRMQEEVVRREEAAVDAQQQKRSIQEEL-----QQLRQSSEAEIQAKARQA 1577
Query: 739 EALE------EEQTRVQELE-ERLARQKEVLESSIAH----------EKRKAKEALESEK 781
EA E EE+ RV L+ E RQ+ E + +KR+A+E E +
Sbjct: 1578 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1637
Query: 782 RKVQDLENHLTQQKEI-------SESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEEL 834
R+VQD E+ +Q E+ +E+ A EK++A +A+E+ + + ++ E RL ++ E+
Sbjct: 1638 RQVQD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL--RQAEV 1694
Query: 835 ELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVE 894
E Q + L A A E Q +A+ + K L L E + + V
Sbjct: 1695 ERARQVQVALETAQRSAEA---ELQSKRASFAEKTAQLERSLQE----------EHVAVA 1741
Query: 895 ERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIE 954
+ L+++ + Q + E++R E E + Q+K A + L + ++V Q +
Sbjct: 1742 Q---LREEAERRAQQQAEAERAREEAERELERWQLK--ANEALRLRLQAEEVAQQKSLAQ 1796
Query: 955 GEIATLKDNDPAPKEERPQ---DPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVI 1011
E K + A +E R + + E + +++ + + + A Q+ L+ ++ +
Sbjct: 1797 AEAE--KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR--LAAEQEL 1852
Query: 1012 MKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSV-LKEKMAQMSSLVEK 1070
++LR A + + + +L E++ L++ Q+ +EL L + A+M L+
Sbjct: 1853 IRLR-----AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1907
Query: 1071 KDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQS 1130
K R EE R++ EK + +L E + + + + ++ + EA + Q+
Sbjct: 1908 KARA----EEESRSTSEKSKQRLEAEAG----RFRELAEEAARLRALAEEA----KRQRQ 1955
Query: 1131 FSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMEN 1190
++ + + E V+ + A+ E E E A K+ +NE L+ L +
Sbjct: 1956 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK--EKEAENER---LRRLAEDE 2010
Query: 1191 NVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMS 1250
Q+ R+E A Q+ K D+ E L K
Sbjct: 2011 AFQR------------RRLEEQAAQH---------------KADIEERLAQLRK------ 2037
Query: 1251 KTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRG 1310
S ++ G V R++ E+ + + +L+ +LGR
Sbjct: 2038 ---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR------- 2087
Query: 1311 YEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAI 1370
+ E RSK E+ ++ +L AEE+ +EA ER++ L E+ R
Sbjct: 2088 IRSNAEDTLRSKEQAELEAARQRQLA------AEEERRRREAEERVQKSLAAEEEAARQR 2141
Query: 1371 RQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
+ + K+++ R LR+ +S++ L
Sbjct: 2142 KAALEEVERLKAKVEEARR-LRERAEQESARQL 2173
Score = 70.5 bits (171), Expect = 1e-11
Identities = 159/756 (21%), Positives = 301/756 (39%), Gaps = 103/756 (13%)
Query: 684 REGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEE 743
RE G Y Q+ ++ E +E R Q S L + L T+ +R++ L++
Sbjct: 1093 REYGSCSHHY--QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1150
Query: 744 EQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHL--TQQKEISESN 801
E R E +R+A Q++ K A+ + E+EK + T + E+ +
Sbjct: 1151 EPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1208
Query: 802 IAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKT 861
E+ ++ A+ EK K L R T+ EE+ L+ +E + +E Q
Sbjct: 1209 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQL------------KEAQAV 1255
Query: 862 KATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDE----QE----- 912
AT L ELE TK + + + QQ AL+DE QE
Sbjct: 1256 PAT---------------LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1300
Query: 913 SQRHGFEE-EIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEER 971
QRHG + E+ ++E++ Q L E+ Q V + E+ L +E
Sbjct: 1301 QQRHGERDVEVERWRERVAQ-------LLERWQAVLAQTDVRQRELEQLGRQLRYYRES- 1352
Query: 972 PQDPLVAPMTESSAKDMAYEHL-IDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRG 1030
DPL A + ++ + + + + D A ++++ +Q ++ ++ + + +
Sbjct: 1353 -ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1411
Query: 1031 ELNEKQKMELEQNVVLVQ------------QQSKELSVLKEKM---AQMSSLVEKKDREL 1075
+N + EL+ Q QS SV++E + S L + +
Sbjct: 1412 YINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1471
Query: 1076 KALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLG 1135
K + E LR +E+ RL E++ R Q + A + +Q ++ +L
Sbjct: 1472 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1531
Query: 1136 VRCKGSRHEEVIQRQKKAL---SELRARIKELEKARSPDHKDHQNES----FLDLKNLRM 1188
R + EEV++R++ A+ + R+ +EL++ R + Q ++ + LR+
Sbjct: 1532 QRMQ----EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1587
Query: 1189 ENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLD 1248
E ++ + L ++E Q G G+ E AE E ++ +
Sbjct: 1588 EEEIRVVRL----------QLEATERQRG------GAEGELQALRARAEEAEAQKRQAQE 1631
Query: 1249 MSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELL 1308
++ L +++ S + R K R+ + +L+ Q E L
Sbjct: 1632 EAERL--RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL 1689
Query: 1309 RGYEKDVEQLRRSKVSIEMYQ-SQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRIN 1367
R + +VE+ R+ +V++E Q S A+L+ AE+ A L+ +L+ + Q +
Sbjct: 1690 R--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1747
Query: 1368 RAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
QQ+ +A + + ERE+ R + + + L
Sbjct: 1748 ERRAQQQAEAERA--REEAERELERWQLKANEALRL 1781
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 134 bits (336), Expect = 8e-31
Identities = 263/1257 (20%), Positives = 491/1257 (39%), Gaps = 167/1257 (13%)
Query: 218 EEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSR-- 275
EE LA+Q + E L + + L ++ A + E EL Q++ E R
Sbjct: 1325 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1384
Query: 276 ------QNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEIT 329
Q ++ I ++ Q L + +A EIQ+ Q A ++ ++ EI
Sbjct: 1385 AAVDAQQQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSRLRI--------EEEIR 1433
Query: 330 SLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEA--- 386
++ + E +R G + +L+ + Q +Q +EE L+ Q +D+ +
Sbjct: 1434 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1493
Query: 387 -LGSRCSVLKEELKQED----AHRELR-EAQEKELKLCKTQIQDMEKEMKKLRAELRKSC 440
L SR E +++ A ELR +A+E E +L + +++ + L R +
Sbjct: 1494 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553
Query: 441 TEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLE-HFRSQV 499
E + EK+ E+ ++ + QL+E R + + ERA + E
Sbjct: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1613
Query: 500 IKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENI 559
+KA + + V Q+ + + +++K ++E + +E+
Sbjct: 1614 LKANEALRLRLQAEEVAQQKSLAQ--------AEAEKQKEEAEREARRRGKAEEQAVRQR 1665
Query: 560 EKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEV 619
E L+ Q + L E +L++ L+ Q+ +L+ EE+
Sbjct: 1666 ELAEQELEK-QRQLAEGTAQQRLAAEQELIR-LRAETEQGEQQRQLLE---------EEL 1714
Query: 620 EQLLRDLGILPSSPN--KDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQ 677
+L R+ + ++ + V A KA +E+ + R EA
Sbjct: 1715 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1774
Query: 678 NQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALA---------- 727
+ + +AL E ++R A+E +R E E +LA++ A+
Sbjct: 1775 RELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIGEATRLKTEAE 1831
Query: 728 ---KSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKV 784
K E R++ E+E + + LEE+ A+ K +E +A ++ + LE +K V
Sbjct: 1832 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1891
Query: 785 QD-LENHLTQQKEISESNIAYEKRKA-KEAMEKEKKKVQDLENRLTKQKEELELKEQKED 842
+D L ++EI ++EK A K +E E +++ + KE+ EL+ ++
Sbjct: 1892 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ- 1950
Query: 843 VLNNKLSDALAMVEETQKTKATE----SLKAESLALKLNE-TLAELETTKTKMIMVEERL 897
LA EE ++ +A E SL AE A + + L E+E K K VEE
Sbjct: 1951 -------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK---VEEAR 2000
Query: 898 ILQQKMVKALQDEQESQRH---GFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHK--- 951
L+++ EQES R E + + K HA + E++LQ+ Q +
Sbjct: 2001 RLRERA------EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2054
Query: 952 -KIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEV 1010
++ GE + +E R Q A + ++ E L + Q
Sbjct: 2055 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA--ERLKQSAEEQAQARAQAQAA 2112
Query: 1011 IMKLRKDL-TEAHSRMSDLRGELNEKQ--KMELEQNVVLVQQQSKELSVLKEKMAQMSSL 1067
KLRK+ EA R + L +KQ E+E++ +Q ++ + +++++ +
Sbjct: 2113 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2172
Query: 1068 VEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQE 1127
+E+ D + L+E L+ +L E + R+++Q V E FS
Sbjct: 2173 LEETDHQKNLLDEELQ--------RLKAEATEAARQRSQ----------VEEELFS---- 2210
Query: 1128 QQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLR 1187
++ Q + LS+L+ARI+ +A KD+ + FL + +
Sbjct: 2211 -------------------VRVQMEELSKLKARIEAENRALILRDKDN-TQRFLQEEAEK 2250
Query: 1188 MENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALEL-SEKLY 1246
M+ V + +R+ LA ++ M K V EA L +E
Sbjct: 2251 MK-QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2309
Query: 1247 LDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQL----RQRDLDLVFD------KITQ 1296
L K L + M +E + + RQR L++ + ++ +
Sbjct: 2310 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2369
Query: 1297 LKNQLGRKEELLRGYEKDVEQ----LRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEA 1352
+ R EE + + K E+ L R++++ + + V LE + + L+EA
Sbjct: 2370 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2429
Query: 1353 LERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPS 1409
+ +E + +EK A K+ K+ ++E L +ET + QS L K S
Sbjct: 2430 IAELERE--KEKLQQEA----KLLQLKSEEMQTVQQEQLLQETQA-LQQSFLSEKDS 2479
Score = 129 bits (324), Expect = 2e-29
Identities = 242/1276 (18%), Positives = 500/1276 (39%), Gaps = 178/1276 (13%)
Query: 250 KDVIIANLQNEVAELSQK----VSETTTSRQNEKEISQKCQVLDEDID---AKQKEIQSL 302
+DV + + VA+L ++ +++T ++ +++ ++ + E D A ++ +
Sbjct: 1148 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1207
Query: 303 KSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQ 362
+ QI A+ S+ + + L + + + ++ GE ++ +++++ L
Sbjct: 1208 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1267
Query: 363 VQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQI 422
QL+ S K + SV++E + + EL + +K +
Sbjct: 1268 KAQLEPVASPAKKPKVQSGSE--------SVIQEYVDLRTHYSELTTLTSQYIKFISETL 1319
Query: 423 QDMEKEMK---KLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRES 479
+ ME+E + + RAE R+ E R+ ++ + + + R+ +LQ+ E
Sbjct: 1320 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1379
Query: 480 V-----------IKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKI---T 525
V K +++ + QL I+A +A+ + ++ I +
Sbjct: 1380 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1439
Query: 526 QVTE-DNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSL-DSCQACMKISCCSHDLK 583
+ TE + + L+ + + +++ + E E+LR + D Q +
Sbjct: 1440 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---------RKRQ 1490
Query: 584 KEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSG 643
EV+L ++ + ++ L L EE E+ LR + QVQ
Sbjct: 1491 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV----ERARQVQ---- 1542
Query: 644 NSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQ--ERNRA 701
A+ TA ++A A + A E A+ E Q + + + E Q E RA
Sbjct: 1543 -VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1601
Query: 702 KETLEEERKRMQ-----ELESLLAQQKKALAKSITQ-EKNRVKEALEEEQTRVQELEERL 755
+E E E +R Q L L ++ A KS+ Q E + KE E E R + EE+
Sbjct: 1602 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1661
Query: 756 ARQKEVLESSIAHEKRKA------KEALESEKRKVQDLENHLTQQKEISESNIAYEKRKA 809
RQ+E+ E + +++ A + A E E +++ QQ+++ E +A +R+A
Sbjct: 1662 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1721
Query: 810 KEAMEKEKKKVQDL-------------------ENRLT--KQKEELELKEQKEDVLNNKL 848
A +K ++ +L E+R T K K+ LE + + L +
Sbjct: 1722 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1781
Query: 849 SDALAMVEETQKTK-------ATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQ 901
+ A+ EE ++ + A + +AE + + + E KT+ + + +
Sbjct: 1782 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1841
Query: 902 KMVKALQDEQESQRHGFEEEIMEYKEQI-----------------------------KQH 932
+ ++ L +++ QR EE+ ++K I +Q
Sbjct: 1842 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1901
Query: 933 AQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAP-----MTESSAKD 987
+ I++L+ +K ++E E+ ++ N + Q L A E +
Sbjct: 1902 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1961
Query: 988 MAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLV 1047
E + LAA++E Q++ + +++ +++ + R L E+ + E + + L
Sbjct: 1962 REAEERVQKSLAAEEEAARQRKAAL---EEVERLKAKVEEAR-RLRERAEQESARQLQLA 2017
Query: 1048 QQQSKELSVLKEKMAQMSSLVEKKDREL-------KALEEALRASQEKHRLQLNTEKEQK 1100
Q+ +++ +EK + V++K++EL +++ + LR E R +E +
Sbjct: 2018 QEAAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2075
Query: 1101 PRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRA- 1159
+ + + + Q+E S+ ++ Q+ + + R E + ++A +E A
Sbjct: 2076 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2135
Query: 1160 RIKELEKARSPDHKDHQNESF-------LDLKNLRM---ENNVQKILLDAKPDLPTLSRI 1209
R K+ A HK ++ +L LR+ E + QK LLD +
Sbjct: 2136 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2195
Query: 1210 EILAPQNGLCNARFG--SAMEKSGKMDVAEALELSEKLYLDMSKTLGSLM----NIKNMS 1263
E ++ + F ME+ K+ E + D T L +K ++
Sbjct: 2196 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2255
Query: 1264 GHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKV 1323
+ ++ QE ++ QL + D L Q E++L+ + V++ R K
Sbjct: 2256 EEAARLSVAAQEAARLRQLAEED----------LAQQRALAEKMLKEKMQAVQEATRLKA 2305
Query: 1324 SIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLK 1383
E+ Q Q + E+ L+E E+M QL +E + ++ R+ L+
Sbjct: 2306 EAELLQQQKELAQ-------EQARRLQEDKEQMAQQLAEE---TQGFQRTLEAERQRQLE 2355
Query: 1384 MDQEREMLRKETSSKS 1399
M E E L+ + S
Sbjct: 2356 MSAEAERLKLRVAEMS 2371
Score = 116 bits (290), Expect = 2e-25
Identities = 189/955 (19%), Positives = 410/955 (42%), Gaps = 92/955 (9%)
Query: 240 LSDYEIESKYKDVIIANLQNEVA---ELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQ 296
L++ E+E K + + Q +A EL + +ET Q + + ++ L + A
Sbjct: 1667 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1725
Query: 297 KEIQSLKSQISALQKGY-----SKVLCQTLSERNSEITSLKNEGE-----NLKRDNAITS 346
++ Q L+++++ ++ SK + S SE + + E E L + A
Sbjct: 1726 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1785
Query: 347 GMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSV-LKEELKQEDAHR 405
+ ++ +E + + E + ++ + L + + LKE+ + + R
Sbjct: 1786 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1845
Query: 406 ELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCT-----EQSVISRTLREKSKVEEK- 459
L E + + + + Q + ++++ A+LRK+ ++ ++ TLR++ +VEE+
Sbjct: 1846 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1905
Query: 460 --LQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTD 517
L+ + E+ I+ N E + E + + A+ R + +
Sbjct: 1906 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1965
Query: 518 QQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETT-------ENIEKLRTSLDSCQ 570
+++ + + E +Q+K L++ +L +E E+ +L+ + ++ Q
Sbjct: 1966 ERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2022
Query: 571 ACMKISCCSHDL---KKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVE-QLLRDL 626
++ +H +KE +L Q LQ V + + R A EE Q R+
Sbjct: 2023 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2082
Query: 627 GILPSSPNK-DQVQQFSGNSAVFTAGKAAGASGREGEAERGEAR---ARGEAQSQNQATD 682
+ ++++Q + A A A A EAE+ AR A A Q QA D
Sbjct: 2083 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2142
Query: 683 GR-EGGKALEEYITQERNRAKETLEEERKRMQELE---SLL---AQQKKALAKSITQEKN 735
E K E +++ + ++ L R +++E + +LL Q+ KA A ++++
Sbjct: 2143 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2202
Query: 736 RVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQ- 794
+V+E L + +++EL + AR + + I +K + L+ E K++ + +
Sbjct: 2203 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2262
Query: 795 ---------KEISESNIAYEKRKAKEAMEKEKKKVQDL-----ENRLTKQKEELELKEQK 840
++++E ++A ++ A++ ++++ + VQ+ E L +Q++EL +EQ
Sbjct: 2263 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA-QEQA 2321
Query: 841 EDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQ 900
+ +K A + EETQ + T L+AE + E AE E K ++ +
Sbjct: 2322 RRLQEDKEQMAQQLAEETQGFQRT--LEAERQ--RQLEMSAEAERLKLRVAE------MS 2371
Query: 901 QKMVKALQDEQESQRHGFE-EEIMEYKEQIKQHAQTIV-SLEEKLQKVTQHHKKIEGEIA 958
+ +A +D Q ++ E E + E Q T+V +LE + Q+ +++ IA
Sbjct: 2372 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2431
Query: 959 TLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDL 1018
L+ KE+ Q+ + + + + E L+ + A Q+ LS+++ +++ + +
Sbjct: 2432 ELERE----KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2487
Query: 1019 TEAHSRMSDL-------RGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKK 1071
+ +++ L +L E+Q+ + +Q Q+ + + + + V +K
Sbjct: 2488 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2547
Query: 1072 DRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQ 1126
EL+ LE+ R +E L E+ Q+ R++ Q + + H+E ++SQ
Sbjct: 2548 QEELQQLEQQRRQQEE-----LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2597
Score = 105 bits (261), Expect = 4e-22
Identities = 171/744 (22%), Positives = 307/744 (41%), Gaps = 107/744 (14%)
Query: 260 EVAELSQKVSETTTSRQN-EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLC 318
EV L KV E R+ E+E +++ Q+ E A QK +Q+ + + + + L
Sbjct: 1988 EVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQKRLQAEEKAHAFAVQQKEQELQ 2044
Query: 319 QTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNK 378
QTL + S + L+ E E +R ++ + + + Q + +V + +
Sbjct: 2045 QTLQQEQSVLDQLRGEAEAARR-------AAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2097
Query: 379 DKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRK 438
+ Q +A ++ E+L++E R AQ ++ L + Q D E E K AE
Sbjct: 2098 SAEEQAQAR-AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--- 2153
Query: 439 SCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHF--- 495
+TLR+K++VE++L LQL+E ++++++ L+R +
Sbjct: 2154 ---------QTLRQKAQVEQELTT----LRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2200
Query: 496 RSQVIKATYG-------------------RAKPFRDKPVTD---QQLIEKITQVTEDNIN 533
RSQV + + RA RDK T Q+ EK+ QV E+
Sbjct: 2201 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2260
Query: 534 FQQKKWTLQKETQLSNSKQEETTENIEK-LRTSLDSCQACMKISCCSHDLKKEVDLLQHL 592
+ QL+ + EK L+ + + Q + LK E +LLQ
Sbjct: 2261 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQ- 2312
Query: 593 QVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGK 652
QK + L E+ EQ+ + L + + + + + +
Sbjct: 2313 ---------QKELAQEQARRLQ--EDKEQMAQQLA--EETQGFQRTLEAERQRQLEMSAE 2359
Query: 653 AAGASGREGEAERGEARARGEAQSQNQATDGREGGKALE--EYITQERNRAKETLEEERK 710
A R E R +ARA +AQ + + E G+ L E TQE+ +TLE +R
Sbjct: 2360 AERLKLRVAEMSRAQARAEEDAQRFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQR- 2416
Query: 711 RMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEK 770
Q+ + + ++A+A E R KE L++E +Q E + + V + + E
Sbjct: 2417 --QQSDHDAERLREAIA-----ELEREKEKLQQEAKLLQLKSEEM---QTVQQEQLLQET 2466
Query: 771 RKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLE---NRL 827
+ +++ SEK + E + Q+K E E KA++ E+++++ Q +E RL
Sbjct: 2467 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2526
Query: 828 TKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTK 887
EE ++ + + + + L +E+ Q+ + E L E+ L+ L E E +
Sbjct: 2527 VASMEEARRRQHEAEEGVRRKQEELQQLEQ-QRRQQEELLAEENQRLREQLQLLE-EQHR 2584
Query: 888 TKMIMVEERLILQQKMVKALQDEQES---------QRHGFEEEIMEYKEQIKQHAQTIVS 938
+ EE Q K L + +++ H F+ + Q Q A I+S
Sbjct: 2585 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILS 2643
Query: 939 LEEKLQKVTQHHKKIEGEIATLKD 962
EE LQ++ Q H ++ E+A +D
Sbjct: 2644 AEE-LQRLAQGHTTVD-ELARRED 2665
Score = 95.5 bits (236), Expect = 3e-19
Identities = 155/790 (19%), Positives = 332/790 (42%), Gaps = 111/790 (14%)
Query: 696 QERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQE----- 750
+E A++ EER+R+ E+E+ L +Q++ LA++ Q K + + +E Q R+QE
Sbjct: 1324 EEERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQRMQEEVVRR 1382
Query: 751 -------------LEERLARQKEVLESSIAHEKRKAKEA------LESEKRKVQDLENHL 791
++E L + ++ E+ I + R+A+ A +E E R V+
Sbjct: 1383 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1442
Query: 792 TQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQ-KEELELKEQKEDVLNNKL-S 849
+Q+ +E + + +A+EA E +K++ Q+ RL +Q ++E + K Q E L +++ +
Sbjct: 1443 ERQRGGAEGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1501
Query: 850 DALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQD 909
+A A E+ + +A E L+ ++ + AE+E + + +E ++ +
Sbjct: 1502 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-------TAQRSAEA 1554
Query: 910 EQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIE--------------- 954
E +S+R F E+ + + +++ + L E+ ++ Q + E
Sbjct: 1555 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1614
Query: 955 ------------GEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQK 1002
E+A K A E++ ++ E+ + A E + A++
Sbjct: 1615 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQ 1670
Query: 1003 EILSQQEVIMKLRKDLTEAHSRMSDLRGEL--NEKQKMELEQNVVLVQQQSKELSVLKEK 1060
E+ Q+++ + A + LR E E+Q+ LE+ + +Q +E + +K
Sbjct: 1671 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ---REAAAATQK 1727
Query: 1061 MAQMSSLVEKKDRELKAL-------EEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQ 1113
++ + + K E++ L EE R++ EK + +L E + + + + + +
Sbjct: 1728 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL----EAEAGRFRELAEEAAR 1783
Query: 1114 IEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHK 1173
+ + EA + Q+ ++ + + E V+ + A+ E E E A K
Sbjct: 1784 LRALAEEA----KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK--EK 1837
Query: 1174 DHQNESFLDL------KNLRMENNVQKILLDAKPDLPTLSRI--EILAPQNGLCNARFGS 1225
+ +NE L + R+E + D + L L + L Q GL
Sbjct: 1838 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1897
Query: 1226 AMEKSGKMDVAEA-LELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQ 1284
+ ++ +A E + ++ LG + + N + K + E + QL
Sbjct: 1898 RRQVEEEILALKASFEKAAAGKAELELELGRIRS--NAEDTLRSKEQAELEAARQRQLAA 1955
Query: 1285 RDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDD------ 1338
+ + +++ L +EE R + +E++ R K +E + + E +
Sbjct: 1956 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2015
Query: 1339 IYKEAEEKALLKE------ALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLR 1392
+ +EA +K L E A+++ E +L Q + +++ Q G +A+ + +E E R
Sbjct: 2016 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2075
Query: 1393 KETSSKSSQS 1402
+ +++QS
Sbjct: 2076 VQAEREAAQS 2085
Score = 94.0 bits (232), Expect = 9e-19
Identities = 244/1173 (20%), Positives = 470/1173 (40%), Gaps = 195/1173 (16%)
Query: 278 EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGEN 337
+KE +++C + Q E++ L ++ L KVL L E + +L++E E
Sbjct: 990 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA--LPEPSPAAPTLRSELEL 1047
Query: 338 LKRDNAITSGMVSSLQKDILAKDEQVQQLK----EEVSHLKSQNKDKDHQLEALGSRCSV 393
L K EQV+ L E++ + + E L +
Sbjct: 1048 T------------------LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1089
Query: 394 LKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREK 453
LKE EL EA + LK + Q + + LR ELR + + + E+
Sbjct: 1090 LKEAQAVPATLPEL-EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1148
Query: 454 SKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQV------IKATYGRA 507
E+ +E + L + Q + + V + LE+ QL ++R ++ R
Sbjct: 1149 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1208
Query: 508 KPFRDKPVTDQQLI-EKITQ---VTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLR 563
+ + P+ D Q + E++ Q + E+ +K Q+ + + ++ + +
Sbjct: 1209 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1268
Query: 564 TSLDSCQACMK---ISCCSHDLKKE-VDLLQHL-QVSPPVSGLQKVVLDVLRHALSWLEE 618
L+ + K + S + +E VDL H +++ S K + + LR +EE
Sbjct: 1269 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR----MEE 1324
Query: 619 VEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQN 678
E+L QQ + +AA E + + EA A+ +AQ++
Sbjct: 1325 EERLAE--------------QQRAEERERLAEVEAA----LEKQRQLAEAHAQAKAQAER 1366
Query: 679 QATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVK 738
+A +E + ++E + + A + +++R +EL QQ + +++ Q K R
Sbjct: 1367 EA---KELQQRMQEEVVRREEAAVDAQQQKRSIQEEL-----QQLRQSSEAEIQAKARQA 1418
Query: 739 EALE------EEQTRVQELE-ERLARQKEVLESSIAH----------EKRKAKEALESEK 781
EA E EE+ RV L+ E RQ+ E + +KR+A+E E +
Sbjct: 1419 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1478
Query: 782 RKVQDLENHLTQQKEI-------SESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEEL 834
R+VQD E+ +Q E+ +E+ A EK++A +A+E+ + + ++ E RL ++ E+
Sbjct: 1479 RQVQD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL--RQAEV 1535
Query: 835 ELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVE 894
E Q + L A A E Q +A+ + K L L E + + V
Sbjct: 1536 ERARQVQVALETAQRSAEA---ELQSKRASFAEKTAQLERSLQE----------EHVAVA 1582
Query: 895 ERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIE 954
+ L+++ + Q + E++R E E + Q+K A + L + ++V Q +
Sbjct: 1583 Q---LREEAERRAQQQAEAERAREEAERELERWQLK--ANEALRLRLQAEEVAQQKSLAQ 1637
Query: 955 GEIATLKDNDPAPKEERPQ---DPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVI 1011
E K + A +E R + + E + +++ + + + A Q+ L+ ++ +
Sbjct: 1638 AEAE--KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR--LAAEQEL 1693
Query: 1012 MKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSV-LKEKMAQMSSLVEK 1070
++LR A + + + +L E++ L++ Q+ +EL L + A+M L+
Sbjct: 1694 IRLR-----AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1748
Query: 1071 KDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQS 1130
K R EE R++ EK + +L E + + + + ++ + EA + Q+
Sbjct: 1749 KARA----EEESRSTSEKSKQRLEAEAG----RFRELAEEAARLRALAEEA----KRQRQ 1796
Query: 1131 FSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMEN 1190
++ + + E V+ + A+ E E E A K+ +NE L+ L +
Sbjct: 1797 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK--EKEAENER---LRRLAEDE 1851
Query: 1191 NVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMS 1250
Q+ R+E A Q+ K D+ E L K
Sbjct: 1852 AFQR------------RRLEEQAAQH---------------KADIEERLAQLRK------ 1878
Query: 1251 KTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRG 1310
S ++ G V R++ E+ + + +L+ +LGR
Sbjct: 1879 ---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR------- 1928
Query: 1311 YEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAI 1370
+ E RSK E+ ++ +L AEE+ +EA ER++ L E+ R
Sbjct: 1929 IRSNAEDTLRSKEQAELEAARQRQLA------AEEERRRREAEERVQKSLAAEEEAARQR 1982
Query: 1371 RQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
+ + K+++ R LR+ +S++ L
Sbjct: 1983 KAALEEVERLKAKVEEARR-LRERAEQESARQL 2014
Score = 70.5 bits (171), Expect = 1e-11
Identities = 159/756 (21%), Positives = 301/756 (39%), Gaps = 103/756 (13%)
Query: 684 REGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEE 743
RE G Y Q+ ++ E +E R Q S L + L T+ +R++ L++
Sbjct: 934 REYGSCSHHY--QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 991
Query: 744 EQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHL--TQQKEISESN 801
E R E +R+A Q++ K A+ + E+EK + T + E+ +
Sbjct: 992 EPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1049
Query: 802 IAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKT 861
E+ ++ A+ EK K L R T+ EE+ L+ +E + +E Q
Sbjct: 1050 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQL------------KEAQAV 1096
Query: 862 KATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDE----QE----- 912
AT L ELE TK + + + QQ AL+DE QE
Sbjct: 1097 PAT---------------LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1141
Query: 913 SQRHGFEE-EIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEER 971
QRHG + E+ ++E++ Q L E+ Q V + E+ L +E
Sbjct: 1142 QQRHGERDVEVERWRERVAQ-------LLERWQAVLAQTDVRQRELEQLGRQLRYYRES- 1193
Query: 972 PQDPLVAPMTESSAKDMAYEHL-IDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRG 1030
DPL A + ++ + + + + D A ++++ +Q ++ ++ + + +
Sbjct: 1194 -ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1252
Query: 1031 ELNEKQKMELEQNVVLVQ------------QQSKELSVLKEKM---AQMSSLVEKKDREL 1075
+N + EL+ Q QS SV++E + S L + +
Sbjct: 1253 YINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1312
Query: 1076 KALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLG 1135
K + E LR +E+ RL E++ R Q + A + +Q ++ +L
Sbjct: 1313 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1372
Query: 1136 VRCKGSRHEEVIQRQKKAL---SELRARIKELEKARSPDHKDHQNES----FLDLKNLRM 1188
R + EEV++R++ A+ + R+ +EL++ R + Q ++ + LR+
Sbjct: 1373 QRMQ----EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1428
Query: 1189 ENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLD 1248
E ++ + L ++E Q G G+ E AE E ++ +
Sbjct: 1429 EEEIRVVRL----------QLEATERQRG------GAEGELQALRARAEEAEAQKRQAQE 1472
Query: 1249 MSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELL 1308
++ L +++ S + R K R+ + +L+ Q E L
Sbjct: 1473 EAERL--RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL 1530
Query: 1309 RGYEKDVEQLRRSKVSIEMYQ-SQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRIN 1367
R + +VE+ R+ +V++E Q S A+L+ AE+ A L+ +L+ + Q +
Sbjct: 1531 R--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1588
Query: 1368 RAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
QQ+ +A + + ERE+ R + + + L
Sbjct: 1589 ERRAQQQAEAERA--REEAERELERWQLKANEALRL 1622
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 134 bits (336), Expect = 8e-31
Identities = 263/1257 (20%), Positives = 491/1257 (39%), Gaps = 167/1257 (13%)
Query: 218 EEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSR-- 275
EE LA+Q + E L + + L ++ A + E EL Q++ E R
Sbjct: 1333 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1392
Query: 276 ------QNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEIT 329
Q ++ I ++ Q L + +A EIQ+ Q A ++ ++ EI
Sbjct: 1393 AAVDAQQQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSRLRI--------EEEIR 1441
Query: 330 SLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEA--- 386
++ + E +R G + +L+ + Q +Q +EE L+ Q +D+ +
Sbjct: 1442 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1501
Query: 387 -LGSRCSVLKEELKQED----AHRELR-EAQEKELKLCKTQIQDMEKEMKKLRAELRKSC 440
L SR E +++ A ELR +A+E E +L + +++ + L R +
Sbjct: 1502 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561
Query: 441 TEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLE-HFRSQV 499
E + EK+ E+ ++ + QL+E R + + ERA + E
Sbjct: 1562 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1621
Query: 500 IKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENI 559
+KA + + V Q+ + + +++K ++E + +E+
Sbjct: 1622 LKANEALRLRLQAEEVAQQKSLAQ--------AEAEKQKEEAEREARRRGKAEEQAVRQR 1673
Query: 560 EKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEV 619
E L+ Q + L E +L++ L+ Q+ +L+ EE+
Sbjct: 1674 ELAEQELEK-QRQLAEGTAQQRLAAEQELIR-LRAETEQGEQQRQLLE---------EEL 1722
Query: 620 EQLLRDLGILPSSPN--KDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQ 677
+L R+ + ++ + V A KA +E+ + R EA
Sbjct: 1723 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1782
Query: 678 NQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALA---------- 727
+ + +AL E ++R A+E +R E E +LA++ A+
Sbjct: 1783 RELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIGEATRLKTEAE 1839
Query: 728 ---KSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKV 784
K E R++ E+E + + LEE+ A+ K +E +A ++ + LE +K V
Sbjct: 1840 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1899
Query: 785 QD-LENHLTQQKEISESNIAYEKRKA-KEAMEKEKKKVQDLENRLTKQKEELELKEQKED 842
+D L ++EI ++EK A K +E E +++ + KE+ EL+ ++
Sbjct: 1900 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ- 1958
Query: 843 VLNNKLSDALAMVEETQKTKATE----SLKAESLALKLNE-TLAELETTKTKMIMVEERL 897
LA EE ++ +A E SL AE A + + L E+E K K VEE
Sbjct: 1959 -------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK---VEEAR 2008
Query: 898 ILQQKMVKALQDEQESQRH---GFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHK--- 951
L+++ EQES R E + + K HA + E++LQ+ Q +
Sbjct: 2009 RLRERA------EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2062
Query: 952 -KIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEV 1010
++ GE + +E R Q A + ++ E L + Q
Sbjct: 2063 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA--ERLKQSAEEQAQARAQAQAA 2120
Query: 1011 IMKLRKDL-TEAHSRMSDLRGELNEKQ--KMELEQNVVLVQQQSKELSVLKEKMAQMSSL 1067
KLRK+ EA R + L +KQ E+E++ +Q ++ + +++++ +
Sbjct: 2121 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2180
Query: 1068 VEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQE 1127
+E+ D + L+E L+ +L E + R+++Q V E FS
Sbjct: 2181 LEETDHQKNLLDEELQ--------RLKAEATEAARQRSQ----------VEEELFS---- 2218
Query: 1128 QQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLR 1187
++ Q + LS+L+ARI+ +A KD+ + FL + +
Sbjct: 2219 -------------------VRVQMEELSKLKARIEAENRALILRDKDN-TQRFLQEEAEK 2258
Query: 1188 MENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALEL-SEKLY 1246
M+ V + +R+ LA ++ M K V EA L +E
Sbjct: 2259 MK-QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2317
Query: 1247 LDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQL----RQRDLDLVFD------KITQ 1296
L K L + M +E + + RQR L++ + ++ +
Sbjct: 2318 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2377
Query: 1297 LKNQLGRKEELLRGYEKDVEQ----LRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEA 1352
+ R EE + + K E+ L R++++ + + V LE + + L+EA
Sbjct: 2378 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2437
Query: 1353 LERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPS 1409
+ +E + +EK A K+ K+ ++E L +ET + QS L K S
Sbjct: 2438 IAELERE--KEKLQQEA----KLLQLKSEEMQTVQQEQLLQETQA-LQQSFLSEKDS 2487
Score = 129 bits (324), Expect = 2e-29
Identities = 242/1276 (18%), Positives = 500/1276 (39%), Gaps = 178/1276 (13%)
Query: 250 KDVIIANLQNEVAELSQK----VSETTTSRQNEKEISQKCQVLDEDID---AKQKEIQSL 302
+DV + + VA+L ++ +++T ++ +++ ++ + E D A ++ +
Sbjct: 1156 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1215
Query: 303 KSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQ 362
+ QI A+ S+ + + L + + + ++ GE ++ +++++ L
Sbjct: 1216 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1275
Query: 363 VQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQI 422
QL+ S K + SV++E + + EL + +K +
Sbjct: 1276 KAQLEPVASPAKKPKVQSGSE--------SVIQEYVDLRTHYSELTTLTSQYIKFISETL 1327
Query: 423 QDMEKEMK---KLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRES 479
+ ME+E + + RAE R+ E R+ ++ + + + R+ +LQ+ E
Sbjct: 1328 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1387
Query: 480 V-----------IKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKI---T 525
V K +++ + QL I+A +A+ + ++ I +
Sbjct: 1388 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1447
Query: 526 QVTE-DNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSL-DSCQACMKISCCSHDLK 583
+ TE + + L+ + + +++ + E E+LR + D Q +
Sbjct: 1448 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---------RKRQ 1498
Query: 584 KEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSG 643
EV+L ++ + ++ L L EE E+ LR + QVQ
Sbjct: 1499 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV----ERARQVQ---- 1550
Query: 644 NSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQ--ERNRA 701
A+ TA ++A A + A E A+ E Q + + + E Q E RA
Sbjct: 1551 -VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1609
Query: 702 KETLEEERKRMQ-----ELESLLAQQKKALAKSITQ-EKNRVKEALEEEQTRVQELEERL 755
+E E E +R Q L L ++ A KS+ Q E + KE E E R + EE+
Sbjct: 1610 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1669
Query: 756 ARQKEVLESSIAHEKRKA------KEALESEKRKVQDLENHLTQQKEISESNIAYEKRKA 809
RQ+E+ E + +++ A + A E E +++ QQ+++ E +A +R+A
Sbjct: 1670 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1729
Query: 810 KEAMEKEKKKVQDL-------------------ENRLT--KQKEELELKEQKEDVLNNKL 848
A +K ++ +L E+R T K K+ LE + + L +
Sbjct: 1730 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1789
Query: 849 SDALAMVEETQKTK-------ATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQ 901
+ A+ EE ++ + A + +AE + + + E KT+ + + +
Sbjct: 1790 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1849
Query: 902 KMVKALQDEQESQRHGFEEEIMEYKEQI-----------------------------KQH 932
+ ++ L +++ QR EE+ ++K I +Q
Sbjct: 1850 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1909
Query: 933 AQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAP-----MTESSAKD 987
+ I++L+ +K ++E E+ ++ N + Q L A E +
Sbjct: 1910 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1969
Query: 988 MAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLV 1047
E + LAA++E Q++ + +++ +++ + R L E+ + E + + L
Sbjct: 1970 REAEERVQKSLAAEEEAARQRKAAL---EEVERLKAKVEEAR-RLRERAEQESARQLQLA 2025
Query: 1048 QQQSKELSVLKEKMAQMSSLVEKKDREL-------KALEEALRASQEKHRLQLNTEKEQK 1100
Q+ +++ +EK + V++K++EL +++ + LR E R +E +
Sbjct: 2026 QEAAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2083
Query: 1101 PRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRA- 1159
+ + + + Q+E S+ ++ Q+ + + R E + ++A +E A
Sbjct: 2084 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2143
Query: 1160 RIKELEKARSPDHKDHQNESF-------LDLKNLRM---ENNVQKILLDAKPDLPTLSRI 1209
R K+ A HK ++ +L LR+ E + QK LLD +
Sbjct: 2144 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2203
Query: 1210 EILAPQNGLCNARFG--SAMEKSGKMDVAEALELSEKLYLDMSKTLGSLM----NIKNMS 1263
E ++ + F ME+ K+ E + D T L +K ++
Sbjct: 2204 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2263
Query: 1264 GHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKV 1323
+ ++ QE ++ QL + D L Q E++L+ + V++ R K
Sbjct: 2264 EEAARLSVAAQEAARLRQLAEED----------LAQQRALAEKMLKEKMQAVQEATRLKA 2313
Query: 1324 SIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLK 1383
E+ Q Q + E+ L+E E+M QL +E + ++ R+ L+
Sbjct: 2314 EAELLQQQKELAQ-------EQARRLQEDKEQMAQQLAEE---TQGFQRTLEAERQRQLE 2363
Query: 1384 MDQEREMLRKETSSKS 1399
M E E L+ + S
Sbjct: 2364 MSAEAERLKLRVAEMS 2379
Score = 116 bits (290), Expect = 2e-25
Identities = 189/955 (19%), Positives = 410/955 (42%), Gaps = 92/955 (9%)
Query: 240 LSDYEIESKYKDVIIANLQNEVA---ELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQ 296
L++ E+E K + + Q +A EL + +ET Q + + ++ L + A
Sbjct: 1675 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1733
Query: 297 KEIQSLKSQISALQKGY-----SKVLCQTLSERNSEITSLKNEGE-----NLKRDNAITS 346
++ Q L+++++ ++ SK + S SE + + E E L + A
Sbjct: 1734 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1793
Query: 347 GMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSV-LKEELKQEDAHR 405
+ ++ +E + + E + ++ + L + + LKE+ + + R
Sbjct: 1794 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1853
Query: 406 ELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCT-----EQSVISRTLREKSKVEEK- 459
L E + + + + Q + ++++ A+LRK+ ++ ++ TLR++ +VEE+
Sbjct: 1854 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1913
Query: 460 --LQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTD 517
L+ + E+ I+ N E + E + + A+ R + +
Sbjct: 1914 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1973
Query: 518 QQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETT-------ENIEKLRTSLDSCQ 570
+++ + + E +Q+K L++ +L +E E+ +L+ + ++ Q
Sbjct: 1974 ERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2030
Query: 571 ACMKISCCSHDL---KKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVE-QLLRDL 626
++ +H +KE +L Q LQ V + + R A EE Q R+
Sbjct: 2031 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2090
Query: 627 GILPSSPNK-DQVQQFSGNSAVFTAGKAAGASGREGEAERGEAR---ARGEAQSQNQATD 682
+ ++++Q + A A A A EAE+ AR A A Q QA D
Sbjct: 2091 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2150
Query: 683 GR-EGGKALEEYITQERNRAKETLEEERKRMQELE---SLL---AQQKKALAKSITQEKN 735
E K E +++ + ++ L R +++E + +LL Q+ KA A ++++
Sbjct: 2151 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2210
Query: 736 RVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQ- 794
+V+E L + +++EL + AR + + I +K + L+ E K++ + +
Sbjct: 2211 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2270
Query: 795 ---------KEISESNIAYEKRKAKEAMEKEKKKVQDL-----ENRLTKQKEELELKEQK 840
++++E ++A ++ A++ ++++ + VQ+ E L +Q++EL +EQ
Sbjct: 2271 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA-QEQA 2329
Query: 841 EDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQ 900
+ +K A + EETQ + T L+AE + E AE E K ++ +
Sbjct: 2330 RRLQEDKEQMAQQLAEETQGFQRT--LEAERQ--RQLEMSAEAERLKLRVAE------MS 2379
Query: 901 QKMVKALQDEQESQRHGFE-EEIMEYKEQIKQHAQTIV-SLEEKLQKVTQHHKKIEGEIA 958
+ +A +D Q ++ E E + E Q T+V +LE + Q+ +++ IA
Sbjct: 2380 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2439
Query: 959 TLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDL 1018
L+ KE+ Q+ + + + + E L+ + A Q+ LS+++ +++ + +
Sbjct: 2440 ELERE----KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2495
Query: 1019 TEAHSRMSDL-------RGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKK 1071
+ +++ L +L E+Q+ + +Q Q+ + + + + V +K
Sbjct: 2496 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2555
Query: 1072 DRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQ 1126
EL+ LE+ R +E L E+ Q+ R++ Q + + H+E ++SQ
Sbjct: 2556 QEELQQLEQQRRQQEE-----LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2605
Score = 105 bits (261), Expect = 4e-22
Identities = 171/744 (22%), Positives = 307/744 (41%), Gaps = 107/744 (14%)
Query: 260 EVAELSQKVSETTTSRQN-EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLC 318
EV L KV E R+ E+E +++ Q+ E A QK +Q+ + + + + L
Sbjct: 1996 EVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQKRLQAEEKAHAFAVQQKEQELQ 2052
Query: 319 QTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNK 378
QTL + S + L+ E E +R ++ + + + Q + +V + +
Sbjct: 2053 QTLQQEQSVLDQLRGEAEAARR-------AAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2105
Query: 379 DKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRK 438
+ Q +A ++ E+L++E R AQ ++ L + Q D E E K AE
Sbjct: 2106 SAEEQAQAR-AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--- 2161
Query: 439 SCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHF--- 495
+TLR+K++VE++L LQL+E ++++++ L+R +
Sbjct: 2162 ---------QTLRQKAQVEQELTT----LRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2208
Query: 496 RSQVIKATYG-------------------RAKPFRDKPVTD---QQLIEKITQVTEDNIN 533
RSQV + + RA RDK T Q+ EK+ QV E+
Sbjct: 2209 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2268
Query: 534 FQQKKWTLQKETQLSNSKQEETTENIEK-LRTSLDSCQACMKISCCSHDLKKEVDLLQHL 592
+ QL+ + EK L+ + + Q + LK E +LLQ
Sbjct: 2269 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQ- 2320
Query: 593 QVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGK 652
QK + L E+ EQ+ + L + + + + + +
Sbjct: 2321 ---------QKELAQEQARRLQ--EDKEQMAQQLA--EETQGFQRTLEAERQRQLEMSAE 2367
Query: 653 AAGASGREGEAERGEARARGEAQSQNQATDGREGGKALE--EYITQERNRAKETLEEERK 710
A R E R +ARA +AQ + + E G+ L E TQE+ +TLE +R
Sbjct: 2368 AERLKLRVAEMSRAQARAEEDAQRFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQR- 2424
Query: 711 RMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEK 770
Q+ + + ++A+A E R KE L++E +Q E + + V + + E
Sbjct: 2425 --QQSDHDAERLREAIA-----ELEREKEKLQQEAKLLQLKSEEM---QTVQQEQLLQET 2474
Query: 771 RKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLE---NRL 827
+ +++ SEK + E + Q+K E E KA++ E+++++ Q +E RL
Sbjct: 2475 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2534
Query: 828 TKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTK 887
EE ++ + + + + L +E+ Q+ + E L E+ L+ L E E +
Sbjct: 2535 VASMEEARRRQHEAEEGVRRKQEELQQLEQ-QRRQQEELLAEENQRLREQLQLLE-EQHR 2592
Query: 888 TKMIMVEERLILQQKMVKALQDEQES---------QRHGFEEEIMEYKEQIKQHAQTIVS 938
+ EE Q K L + +++ H F+ + Q Q A I+S
Sbjct: 2593 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILS 2651
Query: 939 LEEKLQKVTQHHKKIEGEIATLKD 962
EE LQ++ Q H ++ E+A +D
Sbjct: 2652 AEE-LQRLAQGHTTVD-ELARRED 2673
Score = 95.5 bits (236), Expect = 3e-19
Identities = 155/790 (19%), Positives = 332/790 (42%), Gaps = 111/790 (14%)
Query: 696 QERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQE----- 750
+E A++ EER+R+ E+E+ L +Q++ LA++ Q K + + +E Q R+QE
Sbjct: 1332 EEERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQRMQEEVVRR 1390
Query: 751 -------------LEERLARQKEVLESSIAHEKRKAKEA------LESEKRKVQDLENHL 791
++E L + ++ E+ I + R+A+ A +E E R V+
Sbjct: 1391 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1450
Query: 792 TQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQ-KEELELKEQKEDVLNNKL-S 849
+Q+ +E + + +A+EA E +K++ Q+ RL +Q ++E + K Q E L +++ +
Sbjct: 1451 ERQRGGAEGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1509
Query: 850 DALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQD 909
+A A E+ + +A E L+ ++ + AE+E + + +E ++ +
Sbjct: 1510 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-------TAQRSAEA 1562
Query: 910 EQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIE--------------- 954
E +S+R F E+ + + +++ + L E+ ++ Q + E
Sbjct: 1563 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1622
Query: 955 ------------GEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQK 1002
E+A K A E++ ++ E+ + A E + A++
Sbjct: 1623 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQ 1678
Query: 1003 EILSQQEVIMKLRKDLTEAHSRMSDLRGEL--NEKQKMELEQNVVLVQQQSKELSVLKEK 1060
E+ Q+++ + A + LR E E+Q+ LE+ + +Q +E + +K
Sbjct: 1679 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ---REAAAATQK 1735
Query: 1061 MAQMSSLVEKKDRELKAL-------EEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQ 1113
++ + + K E++ L EE R++ EK + +L E + + + + + +
Sbjct: 1736 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL----EAEAGRFRELAEEAAR 1791
Query: 1114 IEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHK 1173
+ + EA + Q+ ++ + + E V+ + A+ E E E A K
Sbjct: 1792 LRALAEEA----KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK--EK 1845
Query: 1174 DHQNESFLDL------KNLRMENNVQKILLDAKPDLPTLSRI--EILAPQNGLCNARFGS 1225
+ +NE L + R+E + D + L L + L Q GL
Sbjct: 1846 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1905
Query: 1226 AMEKSGKMDVAEA-LELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQ 1284
+ ++ +A E + ++ LG + + N + K + E + QL
Sbjct: 1906 RRQVEEEILALKASFEKAAAGKAELELELGRIRS--NAEDTLRSKEQAELEAARQRQLAA 1963
Query: 1285 RDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDD------ 1338
+ + +++ L +EE R + +E++ R K +E + + E +
Sbjct: 1964 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2023
Query: 1339 IYKEAEEKALLKE------ALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLR 1392
+ +EA +K L E A+++ E +L Q + +++ Q G +A+ + +E E R
Sbjct: 2024 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2083
Query: 1393 KETSSKSSQS 1402
+ +++QS
Sbjct: 2084 VQAEREAAQS 2093
Score = 94.0 bits (232), Expect = 9e-19
Identities = 244/1173 (20%), Positives = 470/1173 (40%), Gaps = 195/1173 (16%)
Query: 278 EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGEN 337
+KE +++C + Q E++ L ++ L KVL L E + +L++E E
Sbjct: 998 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA--LPEPSPAAPTLRSELEL 1055
Query: 338 LKRDNAITSGMVSSLQKDILAKDEQVQQLK----EEVSHLKSQNKDKDHQLEALGSRCSV 393
L K EQV+ L E++ + + E L +
Sbjct: 1056 T------------------LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1097
Query: 394 LKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREK 453
LKE EL EA + LK + Q + + LR ELR + + + E+
Sbjct: 1098 LKEAQAVPATLPEL-EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1156
Query: 454 SKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQV------IKATYGRA 507
E+ +E + L + Q + + V + LE+ QL ++R ++ R
Sbjct: 1157 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1216
Query: 508 KPFRDKPVTDQQLI-EKITQ---VTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLR 563
+ + P+ D Q + E++ Q + E+ +K Q+ + + ++ + +
Sbjct: 1217 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1276
Query: 564 TSLDSCQACMK---ISCCSHDLKKE-VDLLQHL-QVSPPVSGLQKVVLDVLRHALSWLEE 618
L+ + K + S + +E VDL H +++ S K + + LR +EE
Sbjct: 1277 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR----MEE 1332
Query: 619 VEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQN 678
E+L QQ + +AA E + + EA A+ +AQ++
Sbjct: 1333 EERLAE--------------QQRAEERERLAEVEAA----LEKQRQLAEAHAQAKAQAER 1374
Query: 679 QATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVK 738
+A +E + ++E + + A + +++R +EL QQ + +++ Q K R
Sbjct: 1375 EA---KELQQRMQEEVVRREEAAVDAQQQKRSIQEEL-----QQLRQSSEAEIQAKARQA 1426
Query: 739 EALE------EEQTRVQELE-ERLARQKEVLESSIAH----------EKRKAKEALESEK 781
EA E EE+ RV L+ E RQ+ E + +KR+A+E E +
Sbjct: 1427 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1486
Query: 782 RKVQDLENHLTQQKEI-------SESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEEL 834
R+VQD E+ +Q E+ +E+ A EK++A +A+E+ + + ++ E RL ++ E+
Sbjct: 1487 RQVQD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL--RQAEV 1543
Query: 835 ELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVE 894
E Q + L A A E Q +A+ + K L L E + + V
Sbjct: 1544 ERARQVQVALETAQRSAEA---ELQSKRASFAEKTAQLERSLQE----------EHVAVA 1590
Query: 895 ERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIE 954
+ L+++ + Q + E++R E E + Q+K A + L + ++V Q +
Sbjct: 1591 Q---LREEAERRAQQQAEAERAREEAERELERWQLK--ANEALRLRLQAEEVAQQKSLAQ 1645
Query: 955 GEIATLKDNDPAPKEERPQ---DPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVI 1011
E K + A +E R + + E + +++ + + + A Q+ L+ ++ +
Sbjct: 1646 AEAE--KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR--LAAEQEL 1701
Query: 1012 MKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSV-LKEKMAQMSSLVEK 1070
++LR A + + + +L E++ L++ Q+ +EL L + A+M L+
Sbjct: 1702 IRLR-----AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1756
Query: 1071 KDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQS 1130
K R EE R++ EK + +L E + + + + ++ + EA + Q+
Sbjct: 1757 KARA----EEESRSTSEKSKQRLEAEAG----RFRELAEEAARLRALAEEA----KRQRQ 1804
Query: 1131 FSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMEN 1190
++ + + E V+ + A+ E E E A K+ +NE L+ L +
Sbjct: 1805 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK--EKEAENER---LRRLAEDE 1859
Query: 1191 NVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMS 1250
Q+ R+E A Q+ K D+ E L K
Sbjct: 1860 AFQR------------RRLEEQAAQH---------------KADIEERLAQLRK------ 1886
Query: 1251 KTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRG 1310
S ++ G V R++ E+ + + +L+ +LGR
Sbjct: 1887 ---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR------- 1936
Query: 1311 YEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAI 1370
+ E RSK E+ ++ +L AEE+ +EA ER++ L E+ R
Sbjct: 1937 IRSNAEDTLRSKEQAELEAARQRQLA------AEEERRRREAEERVQKSLAAEEEAARQR 1990
Query: 1371 RQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
+ + K+++ R LR+ +S++ L
Sbjct: 1991 KAALEEVERLKAKVEEARR-LRERAEQESARQL 2022
Score = 70.5 bits (171), Expect = 1e-11
Identities = 159/756 (21%), Positives = 301/756 (39%), Gaps = 103/756 (13%)
Query: 684 REGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEE 743
RE G Y Q+ ++ E +E R Q S L + L T+ +R++ L++
Sbjct: 942 REYGSCSHHY--QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 999
Query: 744 EQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHL--TQQKEISESN 801
E R E +R+A Q++ K A+ + E+EK + T + E+ +
Sbjct: 1000 EPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1057
Query: 802 IAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKT 861
E+ ++ A+ EK K L R T+ EE+ L+ +E + +E Q
Sbjct: 1058 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQL------------KEAQAV 1104
Query: 862 KATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDE----QE----- 912
AT L ELE TK + + + QQ AL+DE QE
Sbjct: 1105 PAT---------------LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1149
Query: 913 SQRHGFEE-EIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEER 971
QRHG + E+ ++E++ Q L E+ Q V + E+ L +E
Sbjct: 1150 QQRHGERDVEVERWRERVAQ-------LLERWQAVLAQTDVRQRELEQLGRQLRYYRES- 1201
Query: 972 PQDPLVAPMTESSAKDMAYEHL-IDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRG 1030
DPL A + ++ + + + + D A ++++ +Q ++ ++ + + +
Sbjct: 1202 -ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1260
Query: 1031 ELNEKQKMELEQNVVLVQ------------QQSKELSVLKEKM---AQMSSLVEKKDREL 1075
+N + EL+ Q QS SV++E + S L + +
Sbjct: 1261 YINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1320
Query: 1076 KALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLG 1135
K + E LR +E+ RL E++ R Q + A + +Q ++ +L
Sbjct: 1321 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1380
Query: 1136 VRCKGSRHEEVIQRQKKAL---SELRARIKELEKARSPDHKDHQNES----FLDLKNLRM 1188
R + EEV++R++ A+ + R+ +EL++ R + Q ++ + LR+
Sbjct: 1381 QRMQ----EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1436
Query: 1189 ENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLD 1248
E ++ + L ++E Q G G+ E AE E ++ +
Sbjct: 1437 EEEIRVVRL----------QLEATERQRG------GAEGELQALRARAEEAEAQKRQAQE 1480
Query: 1249 MSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELL 1308
++ L +++ S + R K R+ + +L+ Q E L
Sbjct: 1481 EAERL--RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL 1538
Query: 1309 RGYEKDVEQLRRSKVSIEMYQ-SQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRIN 1367
R + +VE+ R+ +V++E Q S A+L+ AE+ A L+ +L+ + Q +
Sbjct: 1539 R--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1596
Query: 1368 RAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
QQ+ +A + + ERE+ R + + + L
Sbjct: 1597 ERRAQQQAEAERA--REEAERELERWQLKANEALRL 1630
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 134 bits (336), Expect = 8e-31
Identities = 263/1257 (20%), Positives = 491/1257 (39%), Gaps = 167/1257 (13%)
Query: 218 EEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSR-- 275
EE LA+Q + E L + + L ++ A + E EL Q++ E R
Sbjct: 1374 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1433
Query: 276 ------QNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEIT 329
Q ++ I ++ Q L + +A EIQ+ Q A ++ ++ EI
Sbjct: 1434 AAVDAQQQKRSIQEELQQLRQSSEA---EIQAKARQAEAAERSRLRI--------EEEIR 1482
Query: 330 SLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEA--- 386
++ + E +R G + +L+ + Q +Q +EE L+ Q +D+ +
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1542
Query: 387 -LGSRCSVLKEELKQED----AHRELR-EAQEKELKLCKTQIQDMEKEMKKLRAELRKSC 440
L SR E +++ A ELR +A+E E +L + +++ + L R +
Sbjct: 1543 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602
Query: 441 TEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLE-HFRSQV 499
E + EK+ E+ ++ + QL+E R + + ERA + E
Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662
Query: 500 IKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENI 559
+KA + + V Q+ + + +++K ++E + +E+
Sbjct: 1663 LKANEALRLRLQAEEVAQQKSLAQ--------AEAEKQKEEAEREARRRGKAEEQAVRQR 1714
Query: 560 EKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEV 619
E L+ Q + L E +L++ L+ Q+ +L+ EE+
Sbjct: 1715 ELAEQELEK-QRQLAEGTAQQRLAAEQELIR-LRAETEQGEQQRQLLE---------EEL 1763
Query: 620 EQLLRDLGILPSSPN--KDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQ 677
+L R+ + ++ + V A KA +E+ + R EA
Sbjct: 1764 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1823
Query: 678 NQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALA---------- 727
+ + +AL E ++R A+E +R E E +LA++ A+
Sbjct: 1824 RELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIGEATRLKTEAE 1880
Query: 728 ---KSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKV 784
K E R++ E+E + + LEE+ A+ K +E +A ++ + LE +K V
Sbjct: 1881 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1940
Query: 785 QD-LENHLTQQKEISESNIAYEKRKA-KEAMEKEKKKVQDLENRLTKQKEELELKEQKED 842
+D L ++EI ++EK A K +E E +++ + KE+ EL+ ++
Sbjct: 1941 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ- 1999
Query: 843 VLNNKLSDALAMVEETQKTKATE----SLKAESLALKLNE-TLAELETTKTKMIMVEERL 897
LA EE ++ +A E SL AE A + + L E+E K K VEE
Sbjct: 2000 -------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK---VEEAR 2049
Query: 898 ILQQKMVKALQDEQESQRH---GFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHK--- 951
L+++ EQES R E + + K HA + E++LQ+ Q +
Sbjct: 2050 RLRERA------EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2103
Query: 952 -KIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEV 1010
++ GE + +E R Q A + ++ E L + Q
Sbjct: 2104 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA--ERLKQSAEEQAQARAQAQAA 2161
Query: 1011 IMKLRKDL-TEAHSRMSDLRGELNEKQ--KMELEQNVVLVQQQSKELSVLKEKMAQMSSL 1067
KLRK+ EA R + L +KQ E+E++ +Q ++ + +++++ +
Sbjct: 2162 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2221
Query: 1068 VEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQE 1127
+E+ D + L+E L+ +L E + R+++Q V E FS
Sbjct: 2222 LEETDHQKNLLDEELQ--------RLKAEATEAARQRSQ----------VEEELFS---- 2259
Query: 1128 QQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLR 1187
++ Q + LS+L+ARI+ +A KD+ + FL + +
Sbjct: 2260 -------------------VRVQMEELSKLKARIEAENRALILRDKDN-TQRFLQEEAEK 2299
Query: 1188 MENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALEL-SEKLY 1246
M+ V + +R+ LA ++ M K V EA L +E
Sbjct: 2300 MK-QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2358
Query: 1247 LDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQL----RQRDLDLVFD------KITQ 1296
L K L + M +E + + RQR L++ + ++ +
Sbjct: 2359 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2418
Query: 1297 LKNQLGRKEELLRGYEKDVEQ----LRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEA 1352
+ R EE + + K E+ L R++++ + + V LE + + L+EA
Sbjct: 2419 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2478
Query: 1353 LERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPS 1409
+ +E + +EK A K+ K+ ++E L +ET + QS L K S
Sbjct: 2479 IAELERE--KEKLQQEA----KLLQLKSEEMQTVQQEQLLQETQA-LQQSFLSEKDS 2528
Score = 129 bits (324), Expect = 2e-29
Identities = 242/1276 (18%), Positives = 500/1276 (39%), Gaps = 178/1276 (13%)
Query: 250 KDVIIANLQNEVAELSQK----VSETTTSRQNEKEISQKCQVLDEDID---AKQKEIQSL 302
+DV + + VA+L ++ +++T ++ +++ ++ + E D A ++ +
Sbjct: 1197 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1256
Query: 303 KSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQ 362
+ QI A+ S+ + + L + + + ++ GE ++ +++++ L
Sbjct: 1257 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1316
Query: 363 VQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQI 422
QL+ S K + SV++E + + EL + +K +
Sbjct: 1317 KAQLEPVASPAKKPKVQSGSE--------SVIQEYVDLRTHYSELTTLTSQYIKFISETL 1368
Query: 423 QDMEKEMK---KLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRES 479
+ ME+E + + RAE R+ E R+ ++ + + + R+ +LQ+ E
Sbjct: 1369 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1428
Query: 480 V-----------IKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKI---T 525
V K +++ + QL I+A +A+ + ++ I +
Sbjct: 1429 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1488
Query: 526 QVTE-DNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSL-DSCQACMKISCCSHDLK 583
+ TE + + L+ + + +++ + E E+LR + D Q +
Sbjct: 1489 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---------RKRQ 1539
Query: 584 KEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSG 643
EV+L ++ + ++ L L EE E+ LR + QVQ
Sbjct: 1540 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV----ERARQVQ---- 1591
Query: 644 NSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQ--ERNRA 701
A+ TA ++A A + A E A+ E Q + + + E Q E RA
Sbjct: 1592 -VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1650
Query: 702 KETLEEERKRMQ-----ELESLLAQQKKALAKSITQ-EKNRVKEALEEEQTRVQELEERL 755
+E E E +R Q L L ++ A KS+ Q E + KE E E R + EE+
Sbjct: 1651 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1710
Query: 756 ARQKEVLESSIAHEKRKA------KEALESEKRKVQDLENHLTQQKEISESNIAYEKRKA 809
RQ+E+ E + +++ A + A E E +++ QQ+++ E +A +R+A
Sbjct: 1711 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1770
Query: 810 KEAMEKEKKKVQDL-------------------ENRLT--KQKEELELKEQKEDVLNNKL 848
A +K ++ +L E+R T K K+ LE + + L +
Sbjct: 1771 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1830
Query: 849 SDALAMVEETQKTK-------ATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQ 901
+ A+ EE ++ + A + +AE + + + E KT+ + + +
Sbjct: 1831 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1890
Query: 902 KMVKALQDEQESQRHGFEEEIMEYKEQI-----------------------------KQH 932
+ ++ L +++ QR EE+ ++K I +Q
Sbjct: 1891 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1950
Query: 933 AQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAP-----MTESSAKD 987
+ I++L+ +K ++E E+ ++ N + Q L A E +
Sbjct: 1951 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2010
Query: 988 MAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLV 1047
E + LAA++E Q++ + +++ +++ + R L E+ + E + + L
Sbjct: 2011 REAEERVQKSLAAEEEAARQRKAAL---EEVERLKAKVEEAR-RLRERAEQESARQLQLA 2066
Query: 1048 QQQSKELSVLKEKMAQMSSLVEKKDREL-------KALEEALRASQEKHRLQLNTEKEQK 1100
Q+ +++ +EK + V++K++EL +++ + LR E R +E +
Sbjct: 2067 QEAAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2124
Query: 1101 PRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRA- 1159
+ + + + Q+E S+ ++ Q+ + + R E + ++A +E A
Sbjct: 2125 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2184
Query: 1160 RIKELEKARSPDHKDHQNESF-------LDLKNLRM---ENNVQKILLDAKPDLPTLSRI 1209
R K+ A HK ++ +L LR+ E + QK LLD +
Sbjct: 2185 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2244
Query: 1210 EILAPQNGLCNARFG--SAMEKSGKMDVAEALELSEKLYLDMSKTLGSLM----NIKNMS 1263
E ++ + F ME+ K+ E + D T L +K ++
Sbjct: 2245 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2304
Query: 1264 GHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKV 1323
+ ++ QE ++ QL + D L Q E++L+ + V++ R K
Sbjct: 2305 EEAARLSVAAQEAARLRQLAEED----------LAQQRALAEKMLKEKMQAVQEATRLKA 2354
Query: 1324 SIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLK 1383
E+ Q Q + E+ L+E E+M QL +E + ++ R+ L+
Sbjct: 2355 EAELLQQQKELAQ-------EQARRLQEDKEQMAQQLAEE---TQGFQRTLEAERQRQLE 2404
Query: 1384 MDQEREMLRKETSSKS 1399
M E E L+ + S
Sbjct: 2405 MSAEAERLKLRVAEMS 2420
Score = 116 bits (290), Expect = 2e-25
Identities = 189/955 (19%), Positives = 410/955 (42%), Gaps = 92/955 (9%)
Query: 240 LSDYEIESKYKDVIIANLQNEVA---ELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQ 296
L++ E+E K + + Q +A EL + +ET Q + + ++ L + A
Sbjct: 1716 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1774
Query: 297 KEIQSLKSQISALQKGY-----SKVLCQTLSERNSEITSLKNEGE-----NLKRDNAITS 346
++ Q L+++++ ++ SK + S SE + + E E L + A
Sbjct: 1775 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1834
Query: 347 GMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSV-LKEELKQEDAHR 405
+ ++ +E + + E + ++ + L + + LKE+ + + R
Sbjct: 1835 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1894
Query: 406 ELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCT-----EQSVISRTLREKSKVEEK- 459
L E + + + + Q + ++++ A+LRK+ ++ ++ TLR++ +VEE+
Sbjct: 1895 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1954
Query: 460 --LQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTD 517
L+ + E+ I+ N E + E + + A+ R + +
Sbjct: 1955 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 2014
Query: 518 QQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETT-------ENIEKLRTSLDSCQ 570
+++ + + E +Q+K L++ +L +E E+ +L+ + ++ Q
Sbjct: 2015 ERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2071
Query: 571 ACMKISCCSHDL---KKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVE-QLLRDL 626
++ +H +KE +L Q LQ V + + R A EE Q R+
Sbjct: 2072 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2131
Query: 627 GILPSSPNK-DQVQQFSGNSAVFTAGKAAGASGREGEAERGEAR---ARGEAQSQNQATD 682
+ ++++Q + A A A A EAE+ AR A A Q QA D
Sbjct: 2132 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2191
Query: 683 GR-EGGKALEEYITQERNRAKETLEEERKRMQELE---SLL---AQQKKALAKSITQEKN 735
E K E +++ + ++ L R +++E + +LL Q+ KA A ++++
Sbjct: 2192 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2251
Query: 736 RVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQ- 794
+V+E L + +++EL + AR + + I +K + L+ E K++ + +
Sbjct: 2252 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2311
Query: 795 ---------KEISESNIAYEKRKAKEAMEKEKKKVQDL-----ENRLTKQKEELELKEQK 840
++++E ++A ++ A++ ++++ + VQ+ E L +Q++EL +EQ
Sbjct: 2312 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA-QEQA 2370
Query: 841 EDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQ 900
+ +K A + EETQ + T L+AE + E AE E K ++ +
Sbjct: 2371 RRLQEDKEQMAQQLAEETQGFQRT--LEAERQ--RQLEMSAEAERLKLRVAE------MS 2420
Query: 901 QKMVKALQDEQESQRHGFE-EEIMEYKEQIKQHAQTIV-SLEEKLQKVTQHHKKIEGEIA 958
+ +A +D Q ++ E E + E Q T+V +LE + Q+ +++ IA
Sbjct: 2421 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2480
Query: 959 TLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDL 1018
L+ KE+ Q+ + + + + E L+ + A Q+ LS+++ +++ + +
Sbjct: 2481 ELERE----KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2536
Query: 1019 TEAHSRMSDL-------RGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKK 1071
+ +++ L +L E+Q+ + +Q Q+ + + + + V +K
Sbjct: 2537 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK 2596
Query: 1072 DRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQ 1126
EL+ LE+ R +E L E+ Q+ R++ Q + + H+E ++SQ
Sbjct: 2597 QEELQQLEQQRRQQEE-----LLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2646
Score = 105 bits (261), Expect = 4e-22
Identities = 171/744 (22%), Positives = 307/744 (41%), Gaps = 107/744 (14%)
Query: 260 EVAELSQKVSETTTSRQN-EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLC 318
EV L KV E R+ E+E +++ Q+ E A QK +Q+ + + + + L
Sbjct: 2037 EVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQKRLQAEEKAHAFAVQQKEQELQ 2093
Query: 319 QTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNK 378
QTL + S + L+ E E +R ++ + + + Q + +V + +
Sbjct: 2094 QTLQQEQSVLDQLRGEAEAARR-------AAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2146
Query: 379 DKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRK 438
+ Q +A ++ E+L++E R AQ ++ L + Q D E E K AE
Sbjct: 2147 SAEEQAQAR-AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--- 2202
Query: 439 SCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHF--- 495
+TLR+K++VE++L LQL+E ++++++ L+R +
Sbjct: 2203 ---------QTLRQKAQVEQELTT----LRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2249
Query: 496 RSQVIKATYG-------------------RAKPFRDKPVTD---QQLIEKITQVTEDNIN 533
RSQV + + RA RDK T Q+ EK+ QV E+
Sbjct: 2250 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2309
Query: 534 FQQKKWTLQKETQLSNSKQEETTENIEK-LRTSLDSCQACMKISCCSHDLKKEVDLLQHL 592
+ QL+ + EK L+ + + Q + LK E +LLQ
Sbjct: 2310 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQ- 2361
Query: 593 QVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGK 652
QK + L E+ EQ+ + L + + + + + +
Sbjct: 2362 ---------QKELAQEQARRLQ--EDKEQMAQQLA--EETQGFQRTLEAERQRQLEMSAE 2408
Query: 653 AAGASGREGEAERGEARARGEAQSQNQATDGREGGKALE--EYITQERNRAKETLEEERK 710
A R E R +ARA +AQ + + E G+ L E TQE+ +TLE +R
Sbjct: 2409 AERLKLRVAEMSRAQARAEEDAQRFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQR- 2465
Query: 711 RMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEK 770
Q+ + + ++A+A E R KE L++E +Q E + + V + + E
Sbjct: 2466 --QQSDHDAERLREAIA-----ELEREKEKLQQEAKLLQLKSEEM---QTVQQEQLLQET 2515
Query: 771 RKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLE---NRL 827
+ +++ SEK + E + Q+K E E KA++ E+++++ Q +E RL
Sbjct: 2516 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2575
Query: 828 TKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTK 887
EE ++ + + + + L +E+ Q+ + E L E+ L+ L E E +
Sbjct: 2576 VASMEEARRRQHEAEEGVRRKQEELQQLEQ-QRRQQEELLAEENQRLREQLQLLE-EQHR 2633
Query: 888 TKMIMVEERLILQQKMVKALQDEQES---------QRHGFEEEIMEYKEQIKQHAQTIVS 938
+ EE Q K L + +++ H F+ + Q Q A I+S
Sbjct: 2634 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILS 2692
Query: 939 LEEKLQKVTQHHKKIEGEIATLKD 962
EE LQ++ Q H ++ E+A +D
Sbjct: 2693 AEE-LQRLAQGHTTVD-ELARRED 2714
Score = 95.5 bits (236), Expect = 3e-19
Identities = 155/790 (19%), Positives = 332/790 (42%), Gaps = 111/790 (14%)
Query: 696 QERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQE----- 750
+E A++ EER+R+ E+E+ L +Q++ LA++ Q K + + +E Q R+QE
Sbjct: 1373 EEERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKELQQRMQEEVVRR 1431
Query: 751 -------------LEERLARQKEVLESSIAHEKRKAKEA------LESEKRKVQDLENHL 791
++E L + ++ E+ I + R+A+ A +E E R V+
Sbjct: 1432 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1491
Query: 792 TQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQ-KEELELKEQKEDVLNNKL-S 849
+Q+ +E + + +A+EA E +K++ Q+ RL +Q ++E + K Q E L +++ +
Sbjct: 1492 ERQRGGAEGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA 1550
Query: 850 DALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQD 909
+A A E+ + +A E L+ ++ + AE+E + + +E ++ +
Sbjct: 1551 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-------TAQRSAEA 1603
Query: 910 EQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIE--------------- 954
E +S+R F E+ + + +++ + L E+ ++ Q + E
Sbjct: 1604 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1663
Query: 955 ------------GEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQK 1002
E+A K A E++ ++ E+ + A E + A++
Sbjct: 1664 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEE----AEREARRRGKAEEQAVRQRELAEQ 1719
Query: 1003 EILSQQEVIMKLRKDLTEAHSRMSDLRGEL--NEKQKMELEQNVVLVQQQSKELSVLKEK 1060
E+ Q+++ + A + LR E E+Q+ LE+ + +Q +E + +K
Sbjct: 1720 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ---REAAAATQK 1776
Query: 1061 MAQMSSLVEKKDRELKAL-------EEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQ 1113
++ + + K E++ L EE R++ EK + +L E + + + + + +
Sbjct: 1777 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL----EAEAGRFRELAEEAAR 1832
Query: 1114 IEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHK 1173
+ + EA + Q+ ++ + + E V+ + A+ E E E A K
Sbjct: 1833 LRALAEEA----KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK--EK 1886
Query: 1174 DHQNESFLDL------KNLRMENNVQKILLDAKPDLPTLSRI--EILAPQNGLCNARFGS 1225
+ +NE L + R+E + D + L L + L Q GL
Sbjct: 1887 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1946
Query: 1226 AMEKSGKMDVAEA-LELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQ 1284
+ ++ +A E + ++ LG + + N + K + E + QL
Sbjct: 1947 RRQVEEEILALKASFEKAAAGKAELELELGRIRS--NAEDTLRSKEQAELEAARQRQLAA 2004
Query: 1285 RDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDD------ 1338
+ + +++ L +EE R + +E++ R K +E + + E +
Sbjct: 2005 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2064
Query: 1339 IYKEAEEKALLKE------ALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLR 1392
+ +EA +K L E A+++ E +L Q + +++ Q G +A+ + +E E R
Sbjct: 2065 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2124
Query: 1393 KETSSKSSQS 1402
+ +++QS
Sbjct: 2125 VQAEREAAQS 2134
Score = 94.0 bits (232), Expect = 9e-19
Identities = 244/1173 (20%), Positives = 470/1173 (40%), Gaps = 195/1173 (16%)
Query: 278 EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGEN 337
+KE +++C + Q E++ L ++ L KVL L E + +L++E E
Sbjct: 1039 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA--LPEPSPAAPTLRSELEL 1096
Query: 338 LKRDNAITSGMVSSLQKDILAKDEQVQQLK----EEVSHLKSQNKDKDHQLEALGSRCSV 393
L K EQV+ L E++ + + E L +
Sbjct: 1097 T------------------LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1138
Query: 394 LKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREK 453
LKE EL EA + LK + Q + + LR ELR + + + E+
Sbjct: 1139 LKEAQAVPATLPEL-EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1197
Query: 454 SKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQV------IKATYGRA 507
E+ +E + L + Q + + V + LE+ QL ++R ++ R
Sbjct: 1198 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1257
Query: 508 KPFRDKPVTDQQLI-EKITQ---VTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLR 563
+ + P+ D Q + E++ Q + E+ +K Q+ + + ++ + +
Sbjct: 1258 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1317
Query: 564 TSLDSCQACMK---ISCCSHDLKKE-VDLLQHL-QVSPPVSGLQKVVLDVLRHALSWLEE 618
L+ + K + S + +E VDL H +++ S K + + LR +EE
Sbjct: 1318 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR----MEE 1373
Query: 619 VEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQN 678
E+L QQ + +AA E + + EA A+ +AQ++
Sbjct: 1374 EERLAE--------------QQRAEERERLAEVEAA----LEKQRQLAEAHAQAKAQAER 1415
Query: 679 QATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVK 738
+A +E + ++E + + A + +++R +EL QQ + +++ Q K R
Sbjct: 1416 EA---KELQQRMQEEVVRREEAAVDAQQQKRSIQEEL-----QQLRQSSEAEIQAKARQA 1467
Query: 739 EALE------EEQTRVQELE-ERLARQKEVLESSIAH----------EKRKAKEALESEK 781
EA E EE+ RV L+ E RQ+ E + +KR+A+E E +
Sbjct: 1468 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1527
Query: 782 RKVQDLENHLTQQKEI-------SESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEEL 834
R+VQD E+ +Q E+ +E+ A EK++A +A+E+ + + ++ E RL ++ E+
Sbjct: 1528 RQVQD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL--RQAEV 1584
Query: 835 ELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVE 894
E Q + L A A E Q +A+ + K L L E + + V
Sbjct: 1585 ERARQVQVALETAQRSAEA---ELQSKRASFAEKTAQLERSLQE----------EHVAVA 1631
Query: 895 ERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIE 954
+ L+++ + Q + E++R E E + Q+K A + L + ++V Q +
Sbjct: 1632 Q---LREEAERRAQQQAEAERAREEAERELERWQLK--ANEALRLRLQAEEVAQQKSLAQ 1686
Query: 955 GEIATLKDNDPAPKEERPQ---DPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVI 1011
E K + A +E R + + E + +++ + + + A Q+ L+ ++ +
Sbjct: 1687 AEAE--KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR--LAAEQEL 1742
Query: 1012 MKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSV-LKEKMAQMSSLVEK 1070
++LR A + + + +L E++ L++ Q+ +EL L + A+M L+
Sbjct: 1743 IRLR-----AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1797
Query: 1071 KDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQS 1130
K R EE R++ EK + +L E + + + + ++ + EA + Q+
Sbjct: 1798 KARA----EEESRSTSEKSKQRLEAEAG----RFRELAEEAARLRALAEEA----KRQRQ 1845
Query: 1131 FSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMEN 1190
++ + + E V+ + A+ E E E A K+ +NE L+ L +
Sbjct: 1846 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK--EKEAENER---LRRLAEDE 1900
Query: 1191 NVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMS 1250
Q+ R+E A Q+ K D+ E L K
Sbjct: 1901 AFQR------------RRLEEQAAQH---------------KADIEERLAQLRK------ 1927
Query: 1251 KTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRG 1310
S ++ G V R++ E+ + + +L+ +LGR
Sbjct: 1928 ---ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR------- 1977
Query: 1311 YEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAI 1370
+ E RSK E+ ++ +L AEE+ +EA ER++ L E+ R
Sbjct: 1978 IRSNAEDTLRSKEQAELEAARQRQLA------AEEERRRREAEERVQKSLAAEEEAARQR 2031
Query: 1371 RQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
+ + K+++ R LR+ +S++ L
Sbjct: 2032 KAALEEVERLKAKVEEARR-LRERAEQESARQL 2063
Score = 70.5 bits (171), Expect = 1e-11
Identities = 159/756 (21%), Positives = 301/756 (39%), Gaps = 103/756 (13%)
Query: 684 REGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEE 743
RE G Y Q+ ++ E +E R Q S L + L T+ +R++ L++
Sbjct: 983 REYGSCSHHY--QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1040
Query: 744 EQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHL--TQQKEISESN 801
E R E +R+A Q++ K A+ + E+EK + T + E+ +
Sbjct: 1041 EPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1098
Query: 802 IAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKT 861
E+ ++ A+ EK K L R T+ EE+ L+ +E + +E Q
Sbjct: 1099 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV-LRAHEEQL------------KEAQAV 1145
Query: 862 KATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDE----QE----- 912
AT L ELE TK + + + QQ AL+DE QE
Sbjct: 1146 PAT---------------LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1190
Query: 913 SQRHGFEE-EIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEER 971
QRHG + E+ ++E++ Q L E+ Q V + E+ L +E
Sbjct: 1191 QQRHGERDVEVERWRERVAQ-------LLERWQAVLAQTDVRQRELEQLGRQLRYYRES- 1242
Query: 972 PQDPLVAPMTESSAKDMAYEHL-IDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRG 1030
DPL A + ++ + + + + D A ++++ +Q ++ ++ + + +
Sbjct: 1243 -ADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1301
Query: 1031 ELNEKQKMELEQNVVLVQ------------QQSKELSVLKEKM---AQMSSLVEKKDREL 1075
+N + EL+ Q QS SV++E + S L + +
Sbjct: 1302 YINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI 1361
Query: 1076 KALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLG 1135
K + E LR +E+ RL E++ R Q + A + +Q ++ +L
Sbjct: 1362 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1421
Query: 1136 VRCKGSRHEEVIQRQKKAL---SELRARIKELEKARSPDHKDHQNES----FLDLKNLRM 1188
R + EEV++R++ A+ + R+ +EL++ R + Q ++ + LR+
Sbjct: 1422 QRMQ----EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1477
Query: 1189 ENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLD 1248
E ++ + L ++E Q G G+ E AE E ++ +
Sbjct: 1478 EEEIRVVRL----------QLEATERQRG------GAEGELQALRARAEEAEAQKRQAQE 1521
Query: 1249 MSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELL 1308
++ L +++ S + R K R+ + +L+ Q E L
Sbjct: 1522 EAERL--RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL 1579
Query: 1309 RGYEKDVEQLRRSKVSIEMYQ-SQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRIN 1367
R + +VE+ R+ +V++E Q S A+L+ AE+ A L+ +L+ + Q +
Sbjct: 1580 R--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1637
Query: 1368 RAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
QQ+ +A + + ERE+ R + + + L
Sbjct: 1638 ERRAQQQAEAERA--REEAERELERWQLKANEALRL 1671
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 131 bits (329), Expect = 5e-30
Identities = 273/1339 (20%), Positives = 556/1339 (41%), Gaps = 189/1339 (14%)
Query: 220 DLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVS--ETTTSRQN 277
D++Q+D + ++ + + RL D E + ++ ++ + L S ++
Sbjct: 180 DMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG 239
Query: 278 EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLC-QTLSERNSEITSLKNEGE 336
K + + E DAK K I+ L+ ++ +K + C Q L + E+ L+ E
Sbjct: 240 MKRTESRQHLSVELADAKAK-IRRLRQELE--EKTEQLLDCKQELEQMEIELKRLQQENM 296
Query: 337 NLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKE 396
NL D A ++ M + K +V +L+ EVS K ++ H +E +R LKE
Sbjct: 297 NLLSD-ARSARMYRDELDALREKAVRVDKLESEVSRYK----ERLHDIEFYKARVEELKE 351
Query: 397 ELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKV 456
+ + + + E Q + + ++ ++EKE +L+A+L E+ + ++ K+
Sbjct: 352 DNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDM------DRKKI 405
Query: 457 EEKLQEDSRRKLLQLQEM------GNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPF 510
EE ++E+ ++ Q Q M G I E + + +V + T R
Sbjct: 406 EELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKL 465
Query: 511 RDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQ 570
+ + + +E++ + K ++KE Q + K E I + + SL +CQ
Sbjct: 466 EMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ 525
Query: 571 ACMKISCCSHDLKKE-VDLLQHLQVSPPVSGLQKVVLDV----LRHALSWLEEVEQLLRD 625
K DL KE L + ++ S Q +L+ L +S L + Q+ +
Sbjct: 526 NLSK------DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAE 579
Query: 626 LGILP-SSPNK---DQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGE-----AQS 676
+ NK + +++ S + K E E+GE E +
Sbjct: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 639
Query: 677 QNQATDGR--------EGGKALEE---YITQERNRAKETLEEERKRMQELESLLAQQKKA 725
+N+ + E +ALE+ + +E + K+TL+ + +LESL + +
Sbjct: 640 ENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQL 699
Query: 726 LAKSITQEKN-------RVKEA-LEEEQTRVQELEERLARQKEVLESSIAH--------- 768
+++ +N +K A L+ E ++ +E+L + E+L++S
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQ 759
Query: 769 ----EKRKAKEALESEKRKVQDLENHL--------TQQKEISESNIAYEKRKAKEAMEKE 816
E ++ ++ LE+ +K+Q LE+ L T QK + E I+ K E +EKE
Sbjct: 760 GLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS---SKRLEQLEKE 816
Query: 817 KKKVQDLENRLTKQKEELE-----LKEQKE--DVLNNKLSDALAMVEETQKTKATE-SLK 868
K ++ ++L K K++LE L++Q E D + + + +E+ KT + E +
Sbjct: 817 NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIY 876
Query: 869 AESLAL-----KLNETLAELETTKTKMI------MVEERLILQQ---------------- 901
ES K N+ L + T K + +V E+L QQ
Sbjct: 877 KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG 936
Query: 902 -KMVKALQDEQ--ESQRHGFEEEIME--YKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGE 956
+ L DEQ + R+ E +E K+ ++ + I +LE +L++ T +++++ E
Sbjct: 937 LNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQE 996
Query: 957 IATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEH-----------LIDDLLAAQKEIL 1005
+ T+K N A K+ + ++ +V S +D +E + D L+ ++
Sbjct: 997 LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNA 1056
Query: 1006 SQQEVIMKLRKDLTEAHSRMSDLRGEL--NEKQKMELEQNVVLVQQQSKELSVLKEKMAQ 1063
+ Q L+ L + ++ ++L+ ++ ++Q + L++ +Q Q+ +L V +
Sbjct: 1057 TLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNS 1116
Query: 1064 MSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFS 1123
S+ + ++ +L + +L E + E+E ++E +H
Sbjct: 1117 QSTSLMNQNAQLLIQQSSLENENE----SVIKEREDLKSLYDSLIKDHEKLELLHER--Q 1170
Query: 1124 SSQEQQSFSDLGVRCKGSRHEEV-----------IQRQKKALSELRARIKELEKARSPDH 1172
+S+ + S G ++ EV + +QK L +L +K ++ ++
Sbjct: 1171 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLEN 1230
Query: 1173 KDHQNESF----LDLKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGL----CNARFG 1224
K+H+ + L +N R+ + ++L + + ++ L + L A F
Sbjct: 1231 KNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFS 1290
Query: 1225 SAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGHV--SMKYLSRQEREKVNQ- 1281
E+ ++D+ + +L+ + L +S+ G N++ + H+ ++ L Q R + Q
Sbjct: 1291 KLKEQYQQLDIT-STKLNNQCEL-LSQLKG---NLEEENRHLLDQIQTLMLQNRTLLEQN 1345
Query: 1282 LRQRDLDLV-----FDKITQLKNQLGRKEELLRGYEK--DVEQLRRSKVSIEMYQSQVAK 1334
+ +DL V DK+ +L+ Q + EE + K D RR I + ++ K
Sbjct: 1346 MESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIK 1405
Query: 1335 LEDDIYKEAEEKALL-------KEALERMEHQLCQEKR---INRAIRQQKVGTRKASLKM 1384
+ DI +E ++ L E ++ HQ Q+ N Q +GT+K+S
Sbjct: 1406 SKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSTMN 1465
Query: 1385 DQEREMLRKETSSKSSQSL 1403
D + M+ + S+++L
Sbjct: 1466 DLVQSMVLAGQWTGSTENL 1484
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 131 bits (329), Expect = 5e-30
Identities = 272/1342 (20%), Positives = 553/1342 (41%), Gaps = 188/1342 (14%)
Query: 220 DLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVS--ETTTSRQN 277
D++Q+D + ++ + + RL D E + ++ ++ + L S ++
Sbjct: 180 DMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG 239
Query: 278 EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLC-QTLSERNSEITSLKNEGE 336
K + + E DAK K I+ L+ ++ +K + C Q L + E+ L+ E
Sbjct: 240 MKRTESRQHLSVELADAKAK-IRRLRQELE--EKTEQLLDCKQELEQMEIELKRLQQENM 296
Query: 337 NLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKE 396
NL D A ++ M + K +V +L+ EVS K ++ H +E +R LKE
Sbjct: 297 NLLSD-ARSARMYRDELDALREKAVRVDKLESEVSRYK----ERLHDIEFYKARVEELKE 351
Query: 397 ELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKV 456
+ + + + E Q + + ++ ++EKE +L+A+L E+ + ++ K+
Sbjct: 352 DNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDM------DRKKI 405
Query: 457 EEKLQEDSRRKLLQLQEM------GNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPF 510
EE ++E+ ++ Q Q M G I E + + +V + T R
Sbjct: 406 EELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKL 465
Query: 511 RDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQ 570
+ + + +E++ + K ++KE Q + K E I + + SL +CQ
Sbjct: 466 EMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ 525
Query: 571 ACMKISCCSHDLKKE-VDLLQHLQVSPPVSGLQKVVLDV----LRHALSWLEEVEQLLRD 625
K DL KE L + ++ S Q +L+ L +S L + Q+ +
Sbjct: 526 NLSK------DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAE 579
Query: 626 LGILP-SSPNK---DQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGE-----AQS 676
+ NK + +++ S + K E E+GE E +
Sbjct: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 639
Query: 677 QNQATDGR--------EGGKALEE---YITQERNRAKETLEEERKRMQELESLLAQQKKA 725
+N+ + E +ALE+ + +E + K+TL+ + +LESL + +
Sbjct: 640 ENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQL 699
Query: 726 LAKSITQEKN-------RVKEA-LEEEQTRVQELEERLARQKEVLESSIAH--------- 768
+++ +N +K A L+ E ++ +E+L + E+L++S
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQ 759
Query: 769 ----EKRKAKEALESEKRKVQDLENHL--------TQQKEISESNIAYEKRKAKEAMEKE 816
E ++ ++ LE+ +K+Q LE+ L T QK + E I+ K E +EKE
Sbjct: 760 GLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS---SKRLEQLEKE 816
Query: 817 KKKVQDLENRLTKQKEELE-----LKEQKE--DVLNNKLSDALAMVEETQKTKATE-SLK 868
K ++ ++L K K++LE L++Q E D + + + +E+ KT + E +
Sbjct: 817 NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIY 876
Query: 869 AESLAL-----KLNETLAELETTKTKMI------MVEERLILQQ---------------- 901
ES K N+ L + T K + +V E+L QQ
Sbjct: 877 KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG 936
Query: 902 -KMVKALQDEQES-QRHGFEEEIME--YKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEI 957
+ L DEQ + R+ E +E K+ ++ + I +LE +L++ T +++++ E+
Sbjct: 937 LNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL 996
Query: 958 ATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEH-----------LIDDLLAAQKEILS 1006
T+K N A K+ + ++ +V S +D +E + D L+ ++ +
Sbjct: 997 KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056
Query: 1007 QQEVIMKLRKDLTEAHSRMSDLRGEL--NEKQKMELEQNVVLVQQQSKELSVLKEKMAQM 1064
Q L+ L + ++ ++L+ ++ ++Q + L++ +Q Q+ +L V +
Sbjct: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116
Query: 1065 SSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSS 1124
S+ + ++ +L + +L E + E+E ++E +H +
Sbjct: 1117 STSLMNQNAQLLIQQSSLENENE----SVIKEREDLKSLYDSLIKDHEKLELLHER--QA 1170
Query: 1125 SQEQQSFSDLGVRCKGSRHEEV-----------IQRQKKALSELRARIKELEKARSPDHK 1173
S+ + S G ++ EV + +QK L +L +K ++ ++K
Sbjct: 1171 SEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENK 1230
Query: 1174 DHQNESF----LDLKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGL----CNARFGS 1225
+H+ + L +N R+ + ++L + + ++ L + L A F
Sbjct: 1231 NHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK 1290
Query: 1226 AMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGHV--SMKYLSRQEREKVNQ-L 1282
E+ ++D+ + +L+ + L +S+ G N++ + H+ ++ L Q R + Q +
Sbjct: 1291 LKEQYQQLDIT-STKLNNQCEL-LSQLKG---NLEEENRHLLDQIQTLMLQNRTLLEQNM 1345
Query: 1283 RQRDLDLV-----FDKITQLKNQLGRKEELLRGYEK--DVEQLRRSKVSIEMYQSQVAKL 1335
+DL V DK+ +L+ Q + EE + K D RR I + ++ K
Sbjct: 1346 ESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKS 1405
Query: 1336 EDDIYKEAEEKALL-------KEALERMEHQLCQEKR---INRAIRQQKVGTRKASLKMD 1385
+ DI +E ++ L E ++ HQ Q+ N Q +GT+K+S+
Sbjct: 1406 KKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSMVAL 1465
Query: 1386 QEREMLRKETSSKSSQSLLHSK 1407
+ LR K + +
Sbjct: 1466 KRLPFLRNRPKDKDKMKACYRR 1487
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 131 bits (329), Expect = 5e-30
Identities = 276/1308 (21%), Positives = 527/1308 (40%), Gaps = 222/1308 (16%)
Query: 184 PPVIKQVWTNAMKLSEKSVAEGIPGAVPPAEIYVEEDLAQQDKDEIILLLGKEVSRLSDY 243
P +I+++ T + E P +P E+ L ++++ LL +E+SR+ D
Sbjct: 48 PALIREIVTRNLSQPES------PVLLPATEMASLLSLQEENQ-----LLQQELSRVEDL 96
Query: 244 EIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAK---QKEIQ 300
+S+ + +A N V+E ++ + E E + ++ + ++ + Q+E
Sbjct: 97 LAQSRAERDELAIKYNAVSE---RLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQA 153
Query: 301 SLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKD 360
S + ++ A Q+G + Q + +I K L+
Sbjct: 154 SYRRKLQAYQEGQQRQ-AQLVQRLQGKILQYKKRCSELE--------------------- 191
Query: 361 EQVQQLKEEVSHLKSQN-KDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCK 419
QQL E L+ Q +D +H + L S L+EE ++ + ++ ++L
Sbjct: 192 ---QQLLERSGELEQQRLRDTEHS-QDLESALIRLEEEQQRSASLAQVNAMLREQLDQAG 247
Query: 420 TQIQDMEKEMKKLR---AELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGN 476
+ Q + ++++K+ RK + R E+S E SR LL Q +G
Sbjct: 248 SANQALSEDIRKVTNDWTRCRKELEHREAAWRR-EEESFNAYFSNEHSRLLLLWRQVVGF 306
Query: 477 RE--SVIKINLERAV----GQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTED 530
R S +K+ ER + G+L V +A G + R + +EK
Sbjct: 307 RRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEK------- 359
Query: 531 NINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKK-EVDLL 589
Q Q E QL + E +++++ LD +++ +K+ E L
Sbjct: 360 -----QALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNL 414
Query: 590 QHLQVSPPVSGLQKVVLDVLRHALSWLEE-----VEQLLRDLGILPSSPNKDQVQ-QFSG 643
+ QV+ ++ + + + + LE ++Q LRDL S ++ VQ S
Sbjct: 415 EKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSE 474
Query: 644 NSAVFTAGKAAGASG-------REGEAERGEARARGEAQS-------------------- 676
+A + G G SG R RG + RG + +
Sbjct: 475 RTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQ 534
Query: 677 ------------------QNQATDGREGGKALEEYITQERNR------AKETLEEERKRM 712
+ Q +D +ALEE + + R++ A E + E +R+
Sbjct: 535 VQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRL 594
Query: 713 QELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLE---SSIAHE 769
+ LL+++K LA S+ Q + E L +E+ ++Q +E L RQ++ LE +
Sbjct: 595 RSANELLSREKSNLAHSL-QVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQD 653
Query: 770 KRKAKEALESEKRKVQDLE-NHLTQQKEISESNIAYEKRK-AKEAMEKEKKKVQDLENRL 827
+ + LE R+++ LE KE+ E A + ++ ++ EK +V + +
Sbjct: 654 GARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKA 713
Query: 828 TKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTK 887
+ ELEL K L D+L+ + ++ A + L L +L E + L+ +
Sbjct: 714 EAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQ 773
Query: 888 TKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVT 947
+ +Q+ ++ L+ EQE R G E + ++ + AQ +LE++L +
Sbjct: 774 RQAEQEATVAREEQERLEELRLEQEVARQGLEGSL-----RVAEQAQE--ALEQQLPTLR 826
Query: 948 QHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQ 1007
+++ ++A L ++E Q E+ + A E A +KE L++
Sbjct: 827 HERSQLQEQLAQLSRQLSGREQELEQ-----ARREAQRQVEALER-----AAREKEALAK 876
Query: 1008 QEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKM-AQMSS 1066
+ + ++ E R +K LE ++ VQ+Q +L +E++ A+ +
Sbjct: 877 EHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQA 936
Query: 1067 LVEKKDR---ELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFS 1123
L+ K+ EL L + + A+QEK L +KE +K Q EA +
Sbjct: 937 LLLAKETLTGELAGLRQQIIATQEKASL----DKELMAQKLVQ----------AEREAQA 982
Query: 1124 SSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDL 1183
S +EQ+ + HEE +QR ++ E A +ELE R+ Q E
Sbjct: 983 SLREQR-----------AAHEEDLQRLQR---EKEAAWRELEAERAQLQSQLQREQ---- 1024
Query: 1184 KNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSE 1243
+++L + + LS EI A Q + EK +AL L E
Sbjct: 1025 ---------EELLARLEAEKEELSE-EIAALQQERDEGLLLAESEKQ------QALSLKE 1068
Query: 1244 KLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGR 1303
+S+ LM ++ +S++ + RQ+R+ ++ +++D V ++L++ +
Sbjct: 1069 SEKTALSE---KLMGTRHSLATISLE-MERQKRDAQSR-QEQDRSTVNALTSELRDLRAQ 1123
Query: 1304 KEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEE----KALLKEALERMEHQ 1359
+EE + ++V +L+ + K D +EAEE LL++A + + +
Sbjct: 1124 REEAAAAHAQEVRRLQEQ-------ARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRE 1176
Query: 1360 LCQ------EKRINRAIRQQKVGTRKASL-KMDQEREMLRKETSSKSS 1400
L + E + R +++Q+ G + SL + +ERE LR+ S
Sbjct: 1177 LLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRS 1224
Score = 119 bits (299), Expect = 2e-26
Identities = 189/884 (21%), Positives = 362/884 (40%), Gaps = 105/884 (11%)
Query: 263 ELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLS 322
+LS SE + + + K + + Q+E+Q L+S L + S L +L
Sbjct: 555 QLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSN-LAHSLQ 613
Query: 323 ERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDH 382
+ L+ E E L+ L++ +E+ + ++ + ++ + +
Sbjct: 614 VAQQQAEELRQEREKLQAAQ-------EELRRQRDRLEEEQEDAVQDGARVRRELERSHR 666
Query: 383 QLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTE 442
QLE L + SVL +EL + Q L+ K ++ + + + R EL S T
Sbjct: 667 QLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMT- 725
Query: 443 QSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKA 502
K + EE +DS KL L E ++ K++L R V QLE +S A
Sbjct: 726 ----------KLRAEEASLQDSLSKLSALNESLAQD---KLDLNRLVAQLEEEKS----A 768
Query: 503 TYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKL 562
GR + + ++ E++ ++ + + + L+ +++ QE + + L
Sbjct: 769 LQGRQRQAEQEATVAREEQERLEEL---RLEQEVARQGLEGSLRVAEQAQEALEQQLPTL 825
Query: 563 RTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQL 622
R Q Q Q+S +SG ++ + R A +E +E+
Sbjct: 826 RHERSQLQE------------------QLAQLSRQLSGREQELEQARREAQRQVEALERA 867
Query: 623 LRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATD 682
R+ L VQ + T + A E EA G + E Q Q +
Sbjct: 868 AREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEG---SLFEVQRQLAQLE 924
Query: 683 GREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKA------LAKSITQEKNR 736
R E Q AKETL E ++ + ++A Q+KA +A+ + Q +
Sbjct: 925 ARREQLEAE---GQALLLAKETLTGELAGLR--QQIIATQEKASLDKELMAQKLVQAERE 979
Query: 737 VKEALEEEQTRVQELEERLARQKEV-----------LESSIAHEKRKAKEALESEKRKVQ 785
+ +L E++ +E +RL R+KE L+S + E+ + LE+EK ++
Sbjct: 980 AQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELS 1039
Query: 786 DLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQD--LENRLTKQKEELELKEQKED- 842
+ L Q+++ EK++A E EK + + + R + LE++ QK D
Sbjct: 1040 EEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDA 1099
Query: 843 ------------VLNNKLSDALAMVEETQKTKATE----SLKAESLALKLNETLAELETT 886
L ++L D A EE A E +A L + + L E E
Sbjct: 1100 QSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEEL 1159
Query: 887 KTKMIMVEE-RLILQQKMVKALQDEQESQ--RHGFEEEIMEYKEQIKQHAQTIVSLEEKL 943
+T++ ++E+ R L++++++A + +ESQ R +E E + + + A+ +L
Sbjct: 1160 RTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSN 1219
Query: 944 QKVTQHHKKIEGEIATLK--DNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQ 1001
+++ KK E E +LK + D K ++ A E+ + + L A+
Sbjct: 1220 EELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEAR 1279
Query: 1002 KEILSQQEVIMKLRKDLTEAHSRMSDLRGE--LNEKQKMELEQNVVLVQQQ----SKELS 1055
+E+ + + L + T +++L+G L E+ + E + + ++Q+ L
Sbjct: 1280 RELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLE 1339
Query: 1056 VLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQ 1099
V+++++ +++++ E + E L S E+ R TEK+Q
Sbjct: 1340 VMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEAR---GTEKQQ 1380
Score = 114 bits (285), Expect = 7e-25
Identities = 256/1273 (20%), Positives = 507/1273 (39%), Gaps = 212/1273 (16%)
Query: 217 VEEDLAQQ--DKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTS 274
+ E LAQ D + ++ L +E S L + +++ + + Q + EL +
Sbjct: 744 LNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQG 803
Query: 275 RQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNE 334
+ ++++ Q +A ++++ +L+ + S LQ+ ++ L + LS R E+ + E
Sbjct: 804 LEGSLRVAEQAQ------EALEQQLPTLRHERSQLQEQLAQ-LSRQLSGREQELEQARRE 856
Query: 335 G-------ENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLK------------- 374
E R+ + + L ++A + + + L EE + L+
Sbjct: 857 AQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEV 916
Query: 375 ----SQNKDKDHQLEALGSRCSVLKEELKQEDA--HRELREAQEKELKLCKTQIQDMEKE 428
+Q + + QLEA G + KE L E A +++ QEK + Q + +
Sbjct: 917 QRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQA 976
Query: 429 MKKLRAELRKS-CTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQ----EMGNRESVIKI 483
++ +A LR+ + + R REK +L+ + + QLQ E+ R K
Sbjct: 977 EREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKE 1036
Query: 484 NLERAVGQLEHFRSQ-VIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQ 542
L + L+ R + ++ A + + K L EK+ + ++
Sbjct: 1037 ELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE---ME 1093
Query: 543 KETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQ 602
++ + + S+QE+ + L + L +A + + +H + V LQ
Sbjct: 1094 RQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAH--------------AQEVRRLQ 1139
Query: 603 KVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGE 662
+ D+ + S L E E+L L +L + +D +++ + A + E
Sbjct: 1140 EQARDLGKQRDSCLREAEELRTQLRLLEDA--RDGLRR-----------ELLEAQRKLRE 1186
Query: 663 AERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQ 722
++ G R EA ++ EG K ER + + EE R +++ ES
Sbjct: 1187 SQEGREVQRQEAGELRRSLG--EGAK--------EREALRRSNEELRSAVKKAES----- 1231
Query: 723 KKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKR 782
++ K ++K + LEE +T V + L + +E S +R+ +E +
Sbjct: 1232 ERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQEL--RRQM 1289
Query: 783 KVQDLEN-HLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKE 841
K+ D EN L ++ + +A +R KE+ +++ L RL K + LE+ Q+
Sbjct: 1290 KMLDSENTRLGRELAELQGRLALGERAEKES----RRETLGLRQRLLKGEASLEVMRQEL 1345
Query: 842 DVLNNKLSDA-----------LAMVEETQKTKATESLKAESLALKLNETLAELETTKTKM 890
V KL + L +EE + T+ + A L LKL AE ++
Sbjct: 1346 QVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRL 1405
Query: 891 IMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQH---AQTIVSLEEKLQKVT 947
E R + ++A E QR E ++ + +++ + +
Sbjct: 1406 SAAEGRA----QGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSP 1461
Query: 948 QHHKKIEGEIATLKDNDPAPKEERP--QDPLVAPMTESSAKDM-------AYEHLIDDLL 998
EG L N P+ E P Q P P T ++ D+ A + +L
Sbjct: 1462 ARDAPAEGSGEGL--NSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELR 1519
Query: 999 AAQKE---------ILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQ 1049
+AQ+E L++Q M+ +D + +R +E+ + ++ + VQ
Sbjct: 1520 SAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQA 1579
Query: 1050 Q--SKELSVLKEKMAQMSSL--VEKKDRELKALEEALRASQEK-HRLQLNTEKEQKPRKK 1104
+ +E SV + + + ++L V +R L+A E LRASQEK +++ N K + +++
Sbjct: 1580 ELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRR 1639
Query: 1105 TQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKEL 1164
+ + + V E S E + +QR + LS+ A+ + L
Sbjct: 1640 LKEVLDASESRTVKLELQRRSLEGE-----------------LQRSRLGLSDREAQAQAL 1682
Query: 1165 EKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFG 1224
+ D D ++Q+ + D++ TL L R
Sbjct: 1683 Q-----DRVD----------------SLQRQVADSEVKAGTLQ----------LTVERLN 1711
Query: 1225 SAMEKSGKMDVA---EALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQ 1281
A+ K + + A + L+E L +++ SL + ++ + H+ K L+ E ++ Q
Sbjct: 1712 GALAKVEESEGALRDKVRGLTEAL----AQSSASLNSTRDKNLHL-QKALTACEHDR--Q 1764
Query: 1282 LRQRDLDLVFDKITQLKNQ---LGRKEELLRGYEKDVE--------QLRRSKVSIEMYQS 1330
+ Q LD +++ + Q LG + + LRG D+E QL++ + + Q
Sbjct: 1765 VLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQE 1824
Query: 1331 QVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREM 1390
A + + K +E+ LL+E L ++ L Q + +K +++L+++++R
Sbjct: 1825 GEAAALNTVQKLQDERRLLQERLGSLQRALAQ-------LEAEKREVERSALRLEKDRVA 1877
Query: 1391 LRKETSSKSSQSL 1403
LR+ + L
Sbjct: 1878 LRRTLDKVEREKL 1890
Score = 108 bits (269), Expect = 5e-23
Identities = 246/1166 (21%), Positives = 499/1166 (42%), Gaps = 140/1166 (12%)
Query: 250 KDVIIANLQNEV--AELSQKVSETTTS-RQNEKEISQKCQVLDEDIDAKQKEIQSLKSQI 306
KD+ +Q+++ A+LS +V+E + ++ EK+ +K QV ++D+ K + ++SL+ Q
Sbjct: 379 KDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQV-NKDLTEKLEALESLRLQE 437
Query: 307 -SALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQ 365
+AL+ + L QTL + + S G L SL + + +
Sbjct: 438 QAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSL-RGLSGQRTPSPP 496
Query: 366 LKEEVSHLKSQNKD-----KDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKT 420
+ +S + D AL ++ K +L+ +D R EA + L +
Sbjct: 497 RRSSPGRGRSPRRGPSPACSDSSTLAL-IHSALHKRQLQVQDM-RGRYEASQDLLGTLRK 554
Query: 421 QIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQE----MGN 476
Q+ D E E + L +L++ LR+K+ + ED++R++ +L+ +
Sbjct: 555 QLSDSESERRALEEQLQR-----------LRDKTDGAMQAHEDAQREVQRLRSANELLSR 603
Query: 477 RESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQ 536
+S + +L+ A Q E R + K + + R + +L E+ +D ++
Sbjct: 604 EKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQR----DRLEEEQEDAVQDGARVRR 659
Query: 537 KKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSP 596
+ ++ + K+ + + ++R +L L++++ + +V+
Sbjct: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRAT-----------LQRDMLQAEKAEVAE 708
Query: 597 PVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQ-QFSGNSAVFTAGKAAG 655
++ + ++ L +++ L E L+D S+ N+ Q + N V +
Sbjct: 709 ALTKAEAGRVE-LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKS 767
Query: 656 A-SGREGEAERGEARARGEAQ-------SQNQATDGREGGKALEEYITQERNRAKETLEE 707
A GR+ +AE+ AR E + Q A G EG + E +A+E LE+
Sbjct: 768 ALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAE-------QAQEALEQ 820
Query: 708 ERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIA 767
+ ++ S L +Q L++ ++ + +++A E Q +V+ L ER AR+KE L A
Sbjct: 821 QLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEAL-ERAAREKEAL----A 875
Query: 768 HEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRL 827
E L + +R+ + L T+ R KEA+E +VQ +L
Sbjct: 876 KEHAGLAVQLVAAEREGRTLSEEATR------------LRLEKEALEGSLFEVQRQLAQL 923
Query: 828 TKQKEELELKEQKEDVLNNKLSDALA-MVEETQKTKATESLKAESLALKLNETLAELETT 886
++E+LE + Q + L+ LA + ++ T+ SL E +A KL + E + +
Sbjct: 924 EARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQAS 983
Query: 887 KTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKV 946
+ E+ ++ ++ LQ E+E+ E E + + Q+++ EE L ++
Sbjct: 984 ------LREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQ------EELLARL 1031
Query: 947 TQHHKKIEGEIATL---KDNDPAPKEERPQDPLVAPMTESSA---KDMAYEHLIDDL-LA 999
+++ EIA L +D E Q L +E +A K M H + + L
Sbjct: 1032 EAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE 1091
Query: 1000 AQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKE 1059
+++ Q + R + S + DLR + E+ Q V +Q+Q+++L ++
Sbjct: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQ-REEAAAAHAQEVRRLQEQARDLGKQRD 1150
Query: 1060 KMAQMSSLVEKKDRELKALEEALRAS--QEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPV 1117
+ + + + R L+ + LR + + +L+ + E + R++ S+
Sbjct: 1151 SCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAK 1210
Query: 1118 HTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQN 1177
EA S E+ +R + E K A + ++ LE+AR+ K+
Sbjct: 1211 EREALRRSNEE-------LRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAG- 1262
Query: 1178 ESFLDLKNLRMENNVQKILLDAKPDLPTLSR-IEILAPQNGLCNARFGSAM-EKSGKMDV 1235
+L+ E V++ L+A+ +L L R +++L + N R G + E G++ +
Sbjct: 1263 ----ELRTGLQE--VERSRLEARRELQELRRQMKMLDSE----NTRLGRELAELQGRLAL 1312
Query: 1236 AEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKIT 1295
E E + +TLG + + + G S++ + ++ + +L++++ + T
Sbjct: 1313 GERAEKESR-----RETLG--LRQRLLKGEASLEVMRQELQVAQRKLQEQEGEF----RT 1361
Query: 1296 QLKNQLGRKEELLRGYEK-DVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALE 1354
+ + LG EE RG EK ++ R ++ +E +++ A+L + AE +A +
Sbjct: 1362 RERRLLGSLEE-ARGTEKQQLDHARGLELKLEAARAEAAELGLRL-SAAEGRA------Q 1413
Query: 1355 RMEHQLCQEKRINRAIRQQKVGTRKA 1380
+E +L + + RA Q G R A
Sbjct: 1414 GLEAELARVEVQRRAAEAQLGGLRSA 1439
Score = 100 bits (249), Expect = 1e-20
Identities = 215/1044 (20%), Positives = 417/1044 (39%), Gaps = 174/1044 (16%)
Query: 219 EDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELS---QKVSETTTSR 275
+ L Q +++ L + + D + + K+ L+ E A+L Q+ E +R
Sbjct: 971 QKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLAR 1030
Query: 276 --QNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKN 333
++E+S++ L ++ D +S K Q +L++ L + L + ++
Sbjct: 1031 LEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISL 1090
Query: 334 EGENLKRD------------NAITS---GMVSSLQKDILAKDEQVQQLKEEVSHLKSQNK 378
E E KRD NA+TS + + ++ A ++V++L+E+ L Q
Sbjct: 1091 EMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRD 1150
Query: 379 DKDHQLEALGSRCSVLKEE---LKQE--DAHRELREAQE--------------------K 413
+ E L ++ +L++ L++E +A R+LRE+QE K
Sbjct: 1151 SCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAK 1210
Query: 414 ELKLCKTQIQDMEKEMKKLRAE-----LRKSCTEQSVI----SRTL--REKSKVEEKLQE 462
E + + +++ +KK +E L EQ + +RT +E ++ LQE
Sbjct: 1211 EREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQE 1270
Query: 463 DSRRKL---LQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQ 519
R +L +LQE+ + ++ R +L + ++ + R+ Q+
Sbjct: 1271 VERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQR 1330
Query: 520 LI--EKITQVTEDNINFQQKKWTLQ------KETQLSNSKQE------ETTENIEKLRTS 565
L+ E +V + Q+K Q +E +L S +E + ++ L
Sbjct: 1331 LLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELK 1390
Query: 566 LDSCQA-----CMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVE 620
L++ +A +++S + L ++V + Q L LR AL
Sbjct: 1391 LEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQ---LGGLRSALR------ 1441
Query: 621 QLLRDLGI----------LPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARA 670
R LG+ +P SP +D + SG + S G A +
Sbjct: 1442 ---RGLGLGRAPSPAPRPVPGSPARDAPAEGSGEG--LNSPSTLECSPGSQPPSPGPATS 1496
Query: 671 RGEAQSQNQATDG---------REGGKALEEYITQER--NRAKETLEEER----KRMQEL 715
+A G R + +E TQ NR +E ER R ++L
Sbjct: 1497 PASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQL 1556
Query: 716 ESLLAQQKKALAKSITQEKNRVKE--ALEEEQTRVQELEERL-------------ARQKE 760
+ +A+ ++A +S+ + V+ AL+EE R E E R A + E
Sbjct: 1557 QKAVAESEEA-RRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESE 1615
Query: 761 VLESSIAHEKRKAKEA-LESEKRKVQ---DLENHLTQQKEISESNIAYEKRKAKEAMEKE 816
+ S K KA E LE +KR+++ D T + E+ ++ E ++++ +
Sbjct: 1616 LRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDR 1675
Query: 817 KKKVQDLENR---LTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLA 873
+ + Q L++R L +Q + E+K + +L+ ALA VEE++ K L
Sbjct: 1676 EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRD---KVRGLT 1732
Query: 874 LKLNETLAELETTKTKMIMVE--------ERLILQQKMVKALQ--DEQESQRHGFEEEIM 923
L ++ A L +T+ K + ++ +R +LQ+++ A Q E Q E++
Sbjct: 1733 EALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQ 1792
Query: 924 EYKEQIKQHAQTIVSLEEKLQKVTQ-HHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTE 982
+ ++ V E +LQ++ + ++ EGE A L E R + +
Sbjct: 1793 TLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQR 1852
Query: 983 SSAKDMAYEHLID-DLLAAQKEILSQQEVIMKLRKDLTEAHS---RMSDLRGELN----- 1033
+ A+ A + ++ L +K+ ++ + + K+ ++ +H R+S +G L+
Sbjct: 1853 ALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTG 1912
Query: 1034 --------EKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKA---LEEAL 1082
++Q +LE VV+++Q + + Q L ++ +R A E L
Sbjct: 1913 AELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTL 1972
Query: 1083 RASQEKHRLQLNTEKEQKPRKKTQ 1106
A + HR ++ +EQ K Q
Sbjct: 1973 EARERAHRQRVRGLEEQVSTLKGQ 1996
Score = 72.8 bits (177), Expect = 2e-12
Identities = 112/551 (20%), Positives = 222/551 (40%), Gaps = 79/551 (14%)
Query: 321 LSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDK 380
L E E+ S + E + L+ + + ++ ++ + + + +QL++ V+ + +
Sbjct: 1511 LREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSV 1570
Query: 381 DHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSC 440
D +L + + ++ +E +++ E+E + Q+ +E+ ++ +ELR S
Sbjct: 1571 DGRLSGVQAELALQEESVRRS----------ERERRATLDQVATLERSLQATESELRAS- 1619
Query: 441 TEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVI 500
Q IS K K E E +R+L ++ + +V K+ L+R + E RS++
Sbjct: 1620 --QEKIS-----KMKANETKLEGDKRRLKEVLDASESRTV-KLELQRRSLEGELQRSRL- 1670
Query: 501 KATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIE 560
D+ Q L +++ + + + K TLQ + N + E+
Sbjct: 1671 --------GLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEG 1722
Query: 561 KLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVL----DVLRHALSWL 616
LR + + S S + ++ +L HLQ + + VL D R ALS
Sbjct: 1723 ALRDKVRGLTEALAQSSASLNSTRDKNL--HLQKALTACEHDRQVLQERLDAARQALS-- 1778
Query: 617 EEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQS 676
E + LG +QVQ G A + E A G+ Q
Sbjct: 1779 -EARKQSSSLG--------EQVQTLRGEVA---------------DLELQRVEAEGQLQQ 1814
Query: 677 QNQATDGREGGKALEEYITQERNRAKETLEEERKRMQE-LESLLAQQKKALAKSITQEKN 735
+ R+ G+A Q+ + L+E +Q L L A++++ ++ EK+
Sbjct: 1815 LREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKD 1874
Query: 736 RVK-----EALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLE-- 788
RV + +E E+ R E RL+ +K L+ ++ + + EA +R++Q LE
Sbjct: 1875 RVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEA----QRQIQQLEAQ 1930
Query: 789 ------NHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQ-DLENRLTKQKEELELKEQKE 841
+H Q E+ E ++ E + + + + LE R ++ + E++
Sbjct: 1931 VVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQV 1990
Query: 842 DVLNNKLSDAL 852
L +L L
Sbjct: 1991 STLKGQLQQEL 2001
Score = 45.1 bits (105), Expect = 5e-04
Identities = 104/572 (18%), Positives = 221/572 (38%), Gaps = 84/572 (14%)
Query: 204 EGIPGAVPPAEIYVEEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAE 263
E + GA+ E E AQ+++DE+ +L++ E E LQ VAE
Sbjct: 1505 EAVRGAL--REFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAE 1562
Query: 264 LSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSE 323
S++ + R + + Q +E + ++E ++ Q++ L++ + L
Sbjct: 1563 -SEEARRSVDGRLSGVQAELALQ--EESVRRSERERRATLDQVATLERSLQATESE-LRA 1618
Query: 324 RNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQ 383
+I+ +K L+ D ++ + + + + Q + L+ E+ + D++ Q
Sbjct: 1619 SQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQ 1678
Query: 384 LEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQ 443
+AL R L+ ++ + + + L ++++ E ++ L ++ +
Sbjct: 1679 AQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQS 1738
Query: 444 SVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKAT 503
S + R+K+ ++L++A+ EH R QV++
Sbjct: 1739 SASLNSTRDKN----------------------------LHLQKALTACEHDR-QVLQER 1769
Query: 504 YGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLR 563
A+ + +++ + + + ++ TL+ E ++ E +++LR
Sbjct: 1770 LDAAR-------------QALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLR 1816
Query: 564 TSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLE----EV 619
L Q + E L +Q L + L L+ AL+ LE EV
Sbjct: 1817 EVLRQRQ------------EGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREV 1864
Query: 620 E----QLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQ 675
E +L +D L + +K + ++ + + + GR G EAQ
Sbjct: 1865 ERSALRLEKDRVALRRTLDKVEREKLRSHEDTV---RLSAEKGRLDRTLTGAELELAEAQ 1921
Query: 676 SQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKN 735
Q Q + + + E++ + LE + ++ Q L QQ+ +S +
Sbjct: 1922 RQIQQLEA--------QVVVLEQSHSPAQLEVDAQQQQ----LELQQEVERLRSAQAQTE 1969
Query: 736 RVKEALEE-EQTRVQELEERLARQKEVLESSI 766
R EA E + RV+ LEE+++ K L+ +
Sbjct: 1970 RTLEARERAHRQRVRGLEEQVSTLKGQLQQEL 2001
Score = 33.1 bits (74), Expect = 1.9
Identities = 52/218 (23%), Positives = 98/218 (44%), Gaps = 32/218 (14%)
Query: 985 AKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNV 1044
A+D+A + I L A +EI++ ++L++ S + E+ ++ E+N
Sbjct: 35 ARDLAQDAQITSLPALIREIVT---------RNLSQPESPVLLPATEMASLLSLQ-EENQ 84
Query: 1045 VLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKK 1104
+L Q+ S+ +L + A+ L K + + LE+ALR +L T++ + ++
Sbjct: 85 LLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPG----ELETQEPRGLVRQ 140
Query: 1105 TQTCDTSVQIEPV----HTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELR-- 1158
+ +Q E +A+ Q++Q + L R +G I + KK SEL
Sbjct: 141 SVELRRQLQEEQASYRRKLQAYQEGQQRQ--AQLVQRLQGK-----ILQYKKRCSELEQQ 193
Query: 1159 --ARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQK 1194
R ELE+ R D + Q+ L+ +R+E Q+
Sbjct: 194 LLERSGELEQQRLRDTEHSQD---LESALIRLEEEQQR 228
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 130 bits (327), Expect = 9e-30
Identities = 268/1332 (20%), Positives = 549/1332 (41%), Gaps = 207/1332 (15%)
Query: 217 VEEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQ------NEVAELSQKVSE 270
+E LA + K L L EV+RL ++ + ++ + + NE ++S++ +
Sbjct: 1620 MESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTS 1679
Query: 271 TTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITS 330
TT R + ++ Q C D DA+ Q L I + + + S S T+
Sbjct: 1680 ETTERTPKHDVHQIC-----DKDAQ----QDLNLDIEKITETGAVKPTGECSGEQSPDTN 1730
Query: 331 LKNEGENLKRDNA------ITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQL 384
+ GE+ + ++ SG + + D L E + L+ V ++N H +
Sbjct: 1731 YEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVI 1790
Query: 385 EALGSRCSVLKEELKQEDAHRELREAQ-EKELKLCKTQIQDMEKEMKKLRAELRK----- 438
E + L E+K+ D+ L+E Q +++ C +++ + E+KK ++L +
Sbjct: 1791 EDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEAC-IELEKIVGELKKENSDLSEKLEYF 1849
Query: 439 SCTEQSVISRT------------LREKSKVEE------KLQEDSRRKLLQLQEMGNRESV 480
SC Q ++ R +KS E+ K+ + + + L ++ +R
Sbjct: 1850 SCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRS 1909
Query: 481 IKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWT 540
K ++E LE V K +K L E+++ VT + + + T
Sbjct: 1910 EKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDT 1969
Query: 541 LQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSG 600
+ K+T + E+ E ++L + C C++++ ++K++ +LLQ L S VS
Sbjct: 1970 MSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVA--EAEVKEKTELLQTL--SSDVSE 2025
Query: 601 LQKVVLDVLRHALSWLE---------------EVEQLLRDLGILPSSPNKDQVQQFSGNS 645
L K L+ L LE ++ QL ++ +L Q + +
Sbjct: 2026 LLKDKTH-LQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDY 2084
Query: 646 AVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYI----------- 694
KA A+ E+GE R + +Q + R G + L I
Sbjct: 2085 EKLNVSKALEAA----LVEKGEFALR-LSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIA 2139
Query: 695 --TQERNRAKETLEEERKRM----------QELESLLAQQKKA-----------LAKS-- 729
+ER R ++L+++ + + QEL L A+ KA +A+S
Sbjct: 2140 EKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLK 2199
Query: 730 --------ITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAK-EALESE 780
+ EK + + ++E+Q ++ EL++ L+ K +LE EK +A+ + E
Sbjct: 2200 VFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLE-----EKEQAEIQIKEES 2254
Query: 781 KRKVQDLENHLTQQKEISESNIA----YEKRKAKE-AMEKEKKKVQDLENRLTKQKEELE 835
K V+ L+N L KE++E+ A E KA E +++ ++ L N + K + LE
Sbjct: 2255 KTAVEMLQNQL---KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLE 2311
Query: 836 LKEQKEDVLNNKLSDA-------LAMVEETQKTKATESLKAESLALKLNETLAELETTKT 888
E+K+ + +L ++ VE ++ E AL+ + E+ET K
Sbjct: 2312 ADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKA 2371
Query: 889 KMIMVEERLILQQKMVKALQDEQESQRHGFEEE---IME-------YKEQIKQHAQTIVS 938
K+ + + L + V ++ E+E+ + ++E I E ++ +++ Q V
Sbjct: 2372 KIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQ 2431
Query: 939 LEEK----LQKVTQHHKKIEGEIATLKDNDPA--PKEERPQDPLVAPMTESSAKDMAYEH 992
++EK ++ + K++ +A L ++ A KE+ + E + +
Sbjct: 2432 MKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDE 2491
Query: 993 LIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKM-----ELEQNVVLV 1047
++ + Q + + + ++ L + +S L+ ++ +++++ ++E L
Sbjct: 2492 AKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLW 2551
Query: 1048 QQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQKPR----- 1102
++Q+ EL L ++ Q +++ K+ L+ E L++S + +L K K
Sbjct: 2552 KEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKV 2611
Query: 1103 KKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRH--EEVIQRQKKALSELRAR 1160
K +T +Q E +H A +++ Q+ S R G E I+ K L EL
Sbjct: 2612 NKMTAKETELQRE-MHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLE 2670
Query: 1161 IKELEKARSPDHKD--------HQNESFLDLKNLRMENNVQKILLDAKPDLPT---LSRI 1209
EL+K+ HKD + + L+ E Q +LLD R
Sbjct: 2671 NSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYRE 2730
Query: 1210 EILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMK 1269
++ + + L + + + KS K ++ +L+ + ++ ++ KT ++K
Sbjct: 2731 KLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMD-----------NLK 2779
Query: 1270 YLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQ 1329
Y+++ ++E N+ Q + L+ QL+ + +E+L +K++ QL+ ++ +
Sbjct: 2780 YVNQLKKE--NERAQGKMKLLIKSCKQLEEE----KEIL---QKELSQLQAAQEKQKTGT 2830
Query: 1330 SQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQERE 1389
K+++ + E K L+E + + L +K + I + K+++ +E
Sbjct: 2831 VMDTKVDELTTEIKELKETLEEKTKEADEYL--DKYCSLLISHE---------KLEKAKE 2879
Query: 1390 MLRKETSSKSSQ 1401
ML + + SQ
Sbjct: 2880 MLETQVAHLCSQ 2891
Score = 128 bits (321), Expect = 4e-29
Identities = 222/1043 (21%), Positives = 443/1043 (42%), Gaps = 232/1043 (22%)
Query: 210 VPPAEIYVEEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVS 269
V ++ +E+D ++K ++I+ L +E+S ++ + + + ++ + +LS+K+
Sbjct: 1928 VQTEKLCLEKD--NENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMK 1985
Query: 270 ETTTSRQNEKEISQKC-QVLDEDIDAKQKEIQSLKSQISALQKGY-------------SK 315
E T ++ + C QV + ++ K + +Q+L S +S L K S+
Sbjct: 1986 EKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQ 2045
Query: 316 VLCQTLSERNSEITSLKNEGENLKRDNAITSGMVS-----------SLQKDILAK----- 359
L T E ++I L E E L +++ +S +L+ ++ K
Sbjct: 2046 ALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFAL 2105
Query: 360 -----DEQVQQLKEEVS--------------HLKSQNKDKDHQLEALGSRCSVLKEELKQ 400
E+V QL+ + H+ + K+++ + ++L + L+ EL+
Sbjct: 2106 RLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQM 2165
Query: 401 EDAHREL----REAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKV 456
+ ++EL E + E++ KTQI++M + +K +L +E+ +++ ++EK
Sbjct: 2166 SEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQ 2225
Query: 457 EEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVT 516
+L + L+E E IK + AV L++ ++ +A
Sbjct: 2226 LSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCG-------- 2277
Query: 517 DQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKIS 576
DQ++++ Q + I ++E QL NS IEKLR L++
Sbjct: 2278 DQEIMKATEQSLDPPI---------EEEHQLRNS--------IEKLRARLEA-------- 2312
Query: 577 CCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKD 636
D KK++ +LQ L+ S + L K VE L R+L I + N++
Sbjct: 2313 ----DEKKQLCVLQQLKESEHHADLLK-------------GRVENLERELEI--ARTNQE 2353
Query: 637 QVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEY-IT 695
A A +GE E +A+ G QS G L+ I
Sbjct: 2354 HA--------------ALEAENSKGEVETLKAKIEGMTQSLR--------GLELDVVTIR 2391
Query: 696 QERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKE----ALEEEQTRVQEL 751
E+ L++E++R+ ELE + + + L + QEK ++KE A+E QT+++EL
Sbjct: 2392 SEKENLTNELQKEQERISELEIINSSFENILQEK-EQEKVQMKEKSSTAMEMLQTQLKEL 2450
Query: 752 EERLARQKEVLESSIAHEKRKAK--EALESEKRKV-QDLE----NHLTQQKEISESNIAY 804
ER+A E+ A E+ + E LE EK ++ Q L+ N++ Q ++ +
Sbjct: 2451 NERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVN--GLIQ 2508
Query: 805 EKRKAKEAMEKEKKKVQDLENRLTKQKE------------------ELELK------EQK 840
E K+ +EK+ +++ L+N++ Q++ LEL+ EQK
Sbjct: 2509 EVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQK 2568
Query: 841 EDVLNNK---LSDALAMVEETQKTKATE----SLKAESLALKLNE-TLAELETTKTKMIM 892
VL +K L D L +++ + K E + S K+N+ T E E + M
Sbjct: 2569 IQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEM 2628
Query: 893 VEERLILQQKM----------VKALQDEQESQRHGFEEEIME-----------YKEQIKQ 931
++ LQ+++ ++ L +E +S + +E +E +K+Q+++
Sbjct: 2629 AQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEK 2688
Query: 932 HAQT---IVSLEEKLQKVTQHH--------KKIEGEIATLKDNDPAPKEERPQDPLVAPM 980
+ I + +L + + H K+ E EI T ++ + +E L +
Sbjct: 2689 EGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDL 2748
Query: 981 TESSAKDM-----AYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEK 1035
+SS +++ A ++++L +K + + + +L+K+ A +M +L K
Sbjct: 2749 LKSSKEELNNSLKATTQILEEL---KKTKMDNLKYVNQLKKENERAQGKM-----KLLIK 2800
Query: 1036 QKMELEQNVVLVQQQSKELSVLKEKM---AQMSSLVEKKDRELKALEEALRASQEKH--- 1089
+LE+ ++Q++ +L +EK M + V++ E+K L+E L ++
Sbjct: 2801 SCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEY 2860
Query: 1090 -----RLQLNTEKEQKPRKKTQT 1107
L ++ EK +K ++ +T
Sbjct: 2861 LDKYCSLLISHEKLEKAKEMLET 2883
Score = 102 bits (253), Expect = 3e-21
Identities = 226/1184 (19%), Positives = 478/1184 (40%), Gaps = 145/1184 (12%)
Query: 283 QKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDN 342
QK Q L+ +D +KE Q + Q+ +L+ L ++ ++ + K EG NLKR+N
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAA--------LQKQKQKVENEKTEGTNLKREN 69
Query: 343 AITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQED 402
+ SL+K ++Q + +V+ + Q Q+E L
Sbjct: 70 QRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKL--------------- 114
Query: 403 AHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQE 462
E+ELK CK++++ ++ + L T Q + + L E
Sbjct: 115 ---------EQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYE 165
Query: 463 DSRRKLLQLQEMGNRESVIKINLERAVGQLEHFR-SQVI-KATYGRAKPFRDKPVTDQQL 520
D L+E N+E + LE V L+ + SQ + +AT R + +
Sbjct: 166 D-------LKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQ--ASSSV 216
Query: 521 IEKITQVTEDNINFQQKKWTLQKETQLSN-SKQEETTENIEKLRTSLDSCQACMKISCCS 579
+ T +++ ++ ++++ S S ++E T + L+ + + S
Sbjct: 217 FSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSS 276
Query: 580 HDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSP-NKDQV 638
L ++ Q+ ++ ++ L+ + + + + ++L L K++V
Sbjct: 277 PHLLDQLKA-QNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKV 335
Query: 639 QQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQER 698
+ V T + AS + E+ + + Q Q + +LE+ I ++
Sbjct: 336 LNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARC--SLEQKIKEK- 392
Query: 699 NRAKETLEEERKRMQE----LESLLAQQKKALAKSITQEKN----------RVKEALEEE 744
++ +EE R Q L+ Q K L + + Q KN ++ ++
Sbjct: 393 ---EKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQL 449
Query: 745 QTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAY 804
+ ++E +++L R ++ ++S E + + ++E K++ L++H ++QK ++
Sbjct: 450 ENNLEEFKQKLCRAEQAFQASQIKE-NELRRSMEEMKKENNLLKSH-SEQKAREVCHLEA 507
Query: 805 EKRKAKEAMEKEKKKVQDLENRLTKQKEEL-----ELKEQKEDVLNNKLSDALAMVEETQ 859
E + K+ + + + ++++ + T Q+ L ++ +Q+ + KL A+A +E+ +
Sbjct: 508 ELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQR 567
Query: 860 KTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQE--SQRHG 917
K E +LN+ L++ E ++ E L++K + L++E+ S
Sbjct: 568 DCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALE---LKKKEYEELKEEKTLFSCWKS 624
Query: 918 FEEEIMEYKEQIKQHAQTIVSLEE---KLQKVTQHHKKIEGEIATLKDNDPAPKEERPQD 974
E+++ E K++ Q+ ++ E K Q++ H + + + + +
Sbjct: 625 ENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHN 684
Query: 975 PLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNE 1034
L + E + +AY L QK S Q K +K++ + S L G++ +
Sbjct: 685 VLDSKSVEVETQKLAYMEL------QQKAEFSDQ----KHQKEIENMCLKTSQLTGQVED 734
Query: 1035 -KQKMELEQNVVL-----VQQQSKELSVLKEKM-AQMSSLVEKKD--RELKALEE----- 1080
+ K++L N ++ Q E L++ + ++ +SLV +D R L A ++
Sbjct: 735 LEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMH 794
Query: 1081 -------ALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSD 1133
+ S R + E +Q P+ ++++ V + FS ++Q SD
Sbjct: 795 HSFANIIGEQGSMPSERSECRLEADQSPK------NSAILQNRVDSLEFSLESQKQMNSD 848
Query: 1134 LGVRC------KGSRHEEVI---QRQKKALSELRARIKELEKARSPDHKDHQNESFLDLK 1184
L +C KG E ++ Q + ++E RI +L++ D HQN L
Sbjct: 849 LQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQE----DTSAHQNVVAETLS 904
Query: 1185 NLRMENNVQKILLD----AKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALE 1240
L + ++L D + ++ L + L ++ L + S K +++ +
Sbjct: 905 ALENKEKELQLLNDKVETEQAEIQELKKSNHLL-EDSLKELQLLSETLSLEKKEMSSIIS 963
Query: 1241 LSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQER-EKVNQLRQRDLDLVFDKITQLK- 1298
L+++ ++++ G+L I M + + E R++ + + D+ Q K
Sbjct: 964 LNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKL 1023
Query: 1299 NQLGRKEELLRGYE---KDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALER 1355
L R EE YE + + + +E ++ L ++ E E+ LKEA +
Sbjct: 1024 ILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQ---LKEAFAK 1080
Query: 1356 MEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKS 1399
EHQ K R Q + +++ EM + +SKS
Sbjct: 1081 -EHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKS 1123
Score = 101 bits (251), Expect = 6e-21
Identities = 278/1482 (18%), Positives = 578/1482 (39%), Gaps = 275/1482 (18%)
Query: 126 QAPPPSHIPFHQGVQPAPMQRSWSQAFPRPTVVLPASHRRPVSANKEMFSFVVDDARKPP 185
Q PSH+ + Q P++R +S ++ + S ++ S D++ P
Sbjct: 221 QEKTPSHLSSNS--QRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPH 278
Query: 186 VIKQVWTNAMKLSEKSVAEGIPGAVPPAEIYVEEDLAQQDK-DEIILLLGK-EVSRLSDY 243
++ Q+ +L K I + + +E Q +K E+ L L K +V +
Sbjct: 279 LLDQLKAQNQELRNK-----INELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKE 333
Query: 244 EIESKYKDVIIANL------QNEVAELSQKVSETTT--SRQNEKEISQKCQVLDEDIDAK 295
++ +K +D ++ + L QK+ + T S Q + S +C L++ I K
Sbjct: 334 KVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCS-LEQKIKEK 392
Query: 296 QKEIQSLKSQISALQKGY--------------------SKVLCQTLSERNSEITSLKNEG 335
+KE Q ++S Q+ + +K + L ++TS+K +
Sbjct: 393 EKEFQ---EELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQL 449
Query: 336 EN------LKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGS 389
EN K A + S ++++ L + ++++K+E + LKS ++ K ++ L +
Sbjct: 450 ENNLEEFKQKLCRAEQAFQASQIKENELRR--SMEEMKKENNLLKSHSEQKAREVCHLEA 507
Query: 390 RCSVLK----------EELKQEDAHRE--LREAQEK--------ELKLCKTQIQDMEKE- 428
+K EE+K ++ +E LR+ QEK L+ K + D+EK+
Sbjct: 508 ELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQR 567
Query: 429 -------------MKKLRAELRKSCTEQSVISRTLREKSKVEEKLQED---------SRR 466
+++L +L K+ E + L K K E+L+E+
Sbjct: 568 DCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENE 627
Query: 467 KLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQ 526
KLL E KIN + + +S + R+ + + + +
Sbjct: 628 KLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLD 687
Query: 527 VTEDNINFQQKKW-TLQKETQLSNSKQEETTEN-----------IEKLRTSLD-SCQACM 573
+ Q+ + LQ++ + S+ K ++ EN +E L L M
Sbjct: 688 SKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIM 747
Query: 574 KISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEE------VEQLLRDLG 627
C DL E + L+ L S S + D R L++ ++ ++ + G
Sbjct: 748 DKDRCYQDLHAEYESLRDLLKSKDASLVTNE--DHQRSLLAFDQQPAMHHSFANIIGEQG 805
Query: 628 ILPSSPNKDQVQ--QFSGNSAVFTAGKAAGASGREGEAERG-EARARGEAQSQNQATDGR 684
+PS ++ +++ Q NSA+ R E E++ + + Q Q +
Sbjct: 806 SMPSERSECRLEADQSPKNSAIL--------QNRVDSLEFSLESQKQMNSDLQKQCEELV 857
Query: 685 EGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKE----- 739
+ +EE + + + + E +R+ +L+ + + +A++++ +N+ KE
Sbjct: 858 QIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLN 917
Query: 740 -ALEEEQTRVQELE------ERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLT 792
+E EQ +QEL+ E ++ ++L +++ EK++ + KR++++L
Sbjct: 918 DKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENG 977
Query: 793 QQKEISES------NIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNN 846
KEI+ S N+ + +++ +K + +L ++ ++E+L L ++ E+ N
Sbjct: 978 TLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQY--KQEKLILLQRCEETGN- 1034
Query: 847 KLSDALAMVEETQKTKATESLKAESLALKLNETLA-------ELETTK-----------T 888
A + +QK KA + K L LNE + ELE K T
Sbjct: 1035 ------AYEDLSQKYKAAQE-KNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLT 1087
Query: 889 KMIMVEER---LILQQKMVKAL--------QDEQESQRHGFEEEIMEYKEQ---IKQHAQ 934
K+ EER L+L+ + V+ Q+ +S+ G ++EIM KE+ +++
Sbjct: 1088 KLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVN 1147
Query: 935 TIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLI 994
++ E+L KV + + + + N +E P + K+++ +
Sbjct: 1148 DLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYN 1207
Query: 995 DDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVL------VQ 1048
L+ + + +++ + + K+ + +RG+L +++ + +
Sbjct: 1208 AQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEID 1267
Query: 1049 QQSK------ELSVLKEKMAQMSSLVE---KKDRELKALEEALRASQEKHRLQLNTEKEQ 1099
+ K ELS + A + ++ K EL+ + E L+A + + +LN + +
Sbjct: 1268 AEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSE 1327
Query: 1100 ---KPRKKTQTCDTSVQ----------------IEPVHTEAFSSSQEQQSFSDLGVRCKG 1140
RK + + +E + F +Q L +
Sbjct: 1328 CITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDES 1387
Query: 1141 SRHEEVIQRQKKA---LSELRARIKELEKARSPDHKDH--------QNESFLD---LKNL 1186
+ +E + K+ +EL+ + L+ H H + ++++D +NL
Sbjct: 1388 NSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENL 1447
Query: 1187 RMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLY 1246
+ N++ D ++ L + GL + S + S + Y
Sbjct: 1448 VLSTNLRNFQGDLVKEMQ-------LGLEEGLVPSLSSSCVPDSSSLSSLG----DSSFY 1496
Query: 1247 LDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEE 1306
+ + G + + N+ G VS Q +D VF Q +N L RK E
Sbjct: 1497 RALLEQTGDMSLLSNLEGAVS--------------ANQCSVDEVFCSSLQEEN-LTRK-E 1540
Query: 1307 LLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLK-EALERMEHQLCQEKR 1365
K VE+L + E+Y+ + KLE+ + E + ++K + ++ +E L E++
Sbjct: 1541 TPSAPAKGVEEL---ESLCEVYRQSLEKLEE----KMESQGIMKNKEIQELEQLLSSERQ 1593
Query: 1366 INRAIRQQKVGTRK--------ASLKMDQEREMLRKETSSKS 1399
+R+Q + + +L+M+ + +K+T S
Sbjct: 1594 ELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLS 1635
Score = 89.0 bits (219), Expect = 3e-17
Identities = 150/717 (20%), Positives = 301/717 (41%), Gaps = 84/717 (11%)
Query: 689 ALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRV 748
ALEE+ RA + ++E ++ +L+ QQ++ S+ + K+ +E E+T
Sbjct: 4 ALEEWKEGLPTRALQKIQELEGQLDKLKKE-KQQRQFQLDSLEAALQKQKQKVENEKTEG 62
Query: 749 QELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRK 808
L+ R E+ ES LE K+K+ + + ++ ES + +++ +
Sbjct: 63 TNLKRENQRLMEICES------------LEKTKQKI-------SHELQVKESQVNFQEGQ 103
Query: 809 AKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLK 868
+ KK+++ LE L + K ELE +Q + L+ QK T
Sbjct: 104 ----LNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPC----NTPQKIFTTPLTP 155
Query: 869 AESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQ 928
++ + E L E + VEER L+ + VKALQ ++ SQ + M +++
Sbjct: 156 SQYYSGSKYEDLKEKYNKE-----VEERKRLEAE-VKALQAKKASQT--LPQATMNHRDI 207
Query: 929 IKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAK-- 986
+ A + S+ Q+ T H + ++ + A Q+ + T K
Sbjct: 208 ARHQASS--SVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRD 265
Query: 987 -------DMAYEHLIDDLLAAQKEILSQ-QEVIMKLRKDLTEAHSRMSDLRGELNEKQKM 1038
+ + HL+D L A +E+ ++ E+ ++L + H + +++G++N+ Q++
Sbjct: 266 ANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRL-----QGHEK--EMKGQVNKFQEL 318
Query: 1039 ELEQNVVLVQ--QQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQLNTE 1096
+L+ V+ ++ K L+ ++++ + ++ ++ + ALE+ L+ E
Sbjct: 319 QLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSC----- 373
Query: 1097 KEQKPRKKTQTCDTSVQIEPVHTEAFSS-SQEQQSFSDLGVRC--KGSRHEEVIQRQKKA 1153
Q+ ++ C +I+ E S++Q+SF L C +R + +Q+ K
Sbjct: 374 --QRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNM 431
Query: 1154 LSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLSRIEILA 1213
+ L+A EL+K S + N K R E Q + + +E +
Sbjct: 432 HNVLQA---ELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQI---KENELRRSMEEMK 485
Query: 1214 PQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSR 1273
+N L + + +K+ ++ EA + K L+ S+ M KN S ++ L
Sbjct: 486 KENNLLKSH---SEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQE 542
Query: 1274 QEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQ-- 1331
+ ++ N L L L + L+ Q ++LL+ E +EQL K+S +S+
Sbjct: 543 KINQQENSLTLEKLKLA---VADLEKQRDCSQDLLKKREHHIEQL-NDKLSKTEKESKAL 598
Query: 1332 --VAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQ 1386
+L+ Y+E +E+ L + +L + + Q K+ + LK Q
Sbjct: 599 LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQ 655
Score = 81.3 bits (199), Expect = 6e-15
Identities = 245/1258 (19%), Positives = 477/1258 (37%), Gaps = 179/1258 (14%)
Query: 259 NEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLC 318
N + E SE + R + + +L +D+ + ++S K S LQK C
Sbjct: 799 NIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQ-----C 853
Query: 319 QTLSERNSEITSLKNEGENLKRDN-AITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQN 377
+ L + EI + E + + A TS +S LQ+D A V E +S L +N
Sbjct: 854 EELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVA---ETLSAL--EN 908
Query: 378 KDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELR 437
K+K+ QL L + + E+++ L E KEL+L + +KEM + + +
Sbjct: 909 KEKELQL--LNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNK 966
Query: 438 KSCTEQSVISRTLRE--KSKVEEKLQ------------EDSRRKLLQLQEMGNRESVIKI 483
+ E + + TL+E S +EK+ ++ + + +L + +E +I +
Sbjct: 967 REIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026
Query: 484 NLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNIN-FQQKKWTLQ 542
G SQ KA ++K + L+ + T + E+ N +Q K
Sbjct: 1027 QRCEETGNAYEDLSQKYKAA-------QEKNSKLECLLNECTSLCENRKNELEQLKEAFA 1079
Query: 543 KETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHD---------LKKEVDLLQHLQ 593
KE Q +K E + L L++ Q ++ + LK+E+ L+ Q
Sbjct: 1080 KEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQ 1139
Query: 594 VSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNS-------- 645
+ +QK V D+L+ L +V + + L S P ++ V++
Sbjct: 1140 -----NKMQKEVNDLLQEN-EQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQ 1193
Query: 646 --------------------AVFTAGKAAGASGREGEAE---------RGEARARGEAQS 676
K E E E RG+
Sbjct: 1194 MDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDM 1253
Query: 677 QNQATDGREGGK--ALEEYI-------TQERNRA--KETLEEERKRMQELESLLAQQKKA 725
Q+Q G + + A E+YI T + + A + +L+ ++ ELE + +
Sbjct: 1254 QSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAE 1313
Query: 726 LAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQ 785
+ +T+ + E + + +E+ +L + ++L + E + + Q
Sbjct: 1314 KYELVTELNDSRSECITATRKMAEEV-GKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQ 1372
Query: 786 DLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLN 845
E H + ESN +YE + ++ + +L+ + + E ++ + ++
Sbjct: 1373 PNEQHPVSLAPLDESN-SYEHLTLSD--KEVQMHFAELQEKFLSLQSEHKILHDQHCQMS 1429
Query: 846 NKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVK 905
+K+S+ V +SLKAE+L L N + + K + +EE L+
Sbjct: 1430 SKMSELQTYV---------DSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLV-PSLSSS 1479
Query: 906 ALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQ-KVTQHHKKIEGEIATLKDND 964
+ D G + Y+ ++Q +SL L+ V+ + ++ + +
Sbjct: 1480 CVPDSSSLSSLG---DSSFYRALLEQTGD--MSLLSNLEGAVSANQCSVDEVFCSSLQEE 1534
Query: 965 PAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSR 1024
++E P P + E + Y ++ L E + + IMK K++ E
Sbjct: 1535 NLTRKETPSAP-AKGVEELESLCEVYRQSLEKL-----EEKMESQGIMK-NKEIQELEQL 1587
Query: 1025 MSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRA 1084
+S R EL+ +K L +N Q+ + ++ K+A E+ EL+ L+
Sbjct: 1588 LSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQG 1647
Query: 1085 SQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRC-KGSRH 1143
R L + E + + ++CD S + HT S + E+ D+ C K ++
Sbjct: 1648 LDLSSRSLLGIDTEDAIQGRNESCDISKE----HT---SETTERTPKHDVHQICDKDAQQ 1700
Query: 1144 EEVIQRQKKALSELRARIKELEKARSPD------HKDHQNESFLDLKNLRMENNVQKILL 1197
+ + +K + E +SPD +D S + L + +
Sbjct: 1701 DLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPM 1760
Query: 1198 DAKPDLPTLSRIEILAPQNGLCNARFGSAME-KSGKMD--VAEALELSEKLYL------- 1247
D + + +++ + N R +E + K++ + E EL KL+L
Sbjct: 1761 DFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMT 1820
Query: 1248 ------DMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLR-----QRDLDLVFDKITQ 1296
++ K +G L +N ++Y S +E + ++ DL++ DK ++
Sbjct: 1821 KIEACIELEKIVGELKK-ENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSR 1879
Query: 1297 -------LKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALL 1349
K KE L E ++ ++R K SIE + LE D+ EK L
Sbjct: 1880 EDIGDNVAKVNDSWKERFL-DVENELSRIRSEKASIE---HEALYLEADLEVVQTEKLCL 1935
Query: 1350 KEALERMEHQL-CQEKRIN------RAIRQQKVGTRKASLKMDQEREMLRKETSSKSS 1400
++ E + + C E+ ++ +R + K + +DQ E ++++T S
Sbjct: 1936 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELES 1993
Score = 34.7 bits (78), Expect = 0.67
Identities = 33/164 (20%), Positives = 70/164 (42%), Gaps = 2/164 (1%)
Query: 218 EEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQN 277
+E+ K EI LL + + + ++ + + + + ++Q E ++
Sbjct: 2735 KEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGK 2794
Query: 278 EKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGEN 337
K + + C+ L+E+ + QKE+ L++ + G V+ + E +EI LK E
Sbjct: 2795 MKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTG--TVMDTKVDELTTEIKELKETLEE 2852
Query: 338 LKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKD 381
++ SL ++ + L+ +V+HL SQ +D
Sbjct: 2853 KTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQD 2896
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 130 bits (327), Expect = 9e-30
Identities = 253/1292 (19%), Positives = 521/1292 (40%), Gaps = 178/1292 (13%)
Query: 223 QQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNE-KEI 281
Q DE+ L+ K+ +S + K+ + +Q E+ E + T + + KE
Sbjct: 1391 QPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEH 1450
Query: 282 SQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRD 341
++ + L ++ +++ + + + A Q+ K+ +S + + E ++L+ +
Sbjct: 1451 DERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEA-----LKENKSLQEE 1505
Query: 342 NAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQ- 400
++ G + L K + + QV +QNK+KD L R ++L+EE +
Sbjct: 1506 LSLARGTIERLTKSLADVESQVS----------AQNKEKDTVL----GRLALLQEERDKL 1551
Query: 401 -EDAHRELREAQE--KELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVE 457
+ R L E Q + K ++ + ++ +KL E+ +S+ S + E ++ +
Sbjct: 1552 ITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEI------ESLKSSKIAESTEWQ 1605
Query: 458 EKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTD 517
EK +E + + LQ N + ER +E R + + YG+ + T+
Sbjct: 1606 EKHKELQKEYEILLQSYEN----VSNEAERIQHVVEAVRQEK-QELYGKLRS------TE 1654
Query: 518 QQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSL----DSCQACM 573
E Q+ E ++ K ++K + K E E ++LR + D+ + CM
Sbjct: 1655 ANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECM 1714
Query: 574 KISCCSH-DLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDL-GILPS 631
+ S+ +K+E++ +V L K ++ S EEV+ L + G +
Sbjct: 1715 ETLLSSNASMKEELE-----RVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSK 1769
Query: 632 SPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARG----------EAQSQNQAT 681
N + ++ + V G GE E ++ + A+S N A
Sbjct: 1770 QANLEATEKHDNQTNV----TEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAV 1825
Query: 682 DGREGGKALEEYITQERNRAKET---LEEERKRMQELESLLAQQKKALAKSITQEKNRVK 738
Q+ ++ KE LEEE+++ +E L +K L I+ + +K
Sbjct: 1826 SKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELK 1885
Query: 739 -------------EALEEEQTRV-----------QELEERLARQKEVLESSIAH------ 768
+ ++EE +RV +LEERL Q L SI +
Sbjct: 1886 MLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVT 1945
Query: 769 EKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKE-KKKVQDLE--- 824
+ + E LESE + ++ + L ++K+ + EK K + + KE +K+Q +
Sbjct: 1946 DAQIKNELLESEMKNLKKCVSELEEEKQ----QLVKEKTKVESEIRKEYLEKIQGAQKEP 2001
Query: 825 NRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELE 884
+ KE EL ++K+ + D + E+ + T ++L E+ +LE
Sbjct: 2002 GNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERT----VKALEFVQTESQKDLE 2057
Query: 885 TTKTKMIM-VEERLILQQKMV--KALQDEQESQ-------RHGFEEEIMEYKEQIK-QHA 933
TK + VE R Q ++ K L D+ +S+ ++E+ KE +K Q
Sbjct: 2058 ITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMK 2117
Query: 934 QTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERP--QDPLVAPMTESSAKDMAYE 991
Q LE +L++ + H K E +++ A + E+ ++ + + KD +
Sbjct: 2118 QKDEDLERRLEQAEEKHLK---EKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQ 2174
Query: 992 HLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQS 1051
L ++L ++Q K L + R+ D + K ++ ++ +
Sbjct: 2175 QLQENL----DSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKE 2230
Query: 1052 KELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTS 1111
SVLK+++ QMS +E+ + LE + + K + ++ +++ + + +
Sbjct: 2231 DNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELL 2290
Query: 1112 VQIEPVHTEAFSSSQE-----------QQSFSDLG---VRCKGSRH--EEVIQRQKKALS 1155
Q+E SS E + +DL +CK + E +I++Q+ +
Sbjct: 2291 SQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQ 2350
Query: 1156 ELRARIKELE----KARSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLSRIEI 1211
+ ++LE +R + H+ + + K + + + ++ + A +L EI
Sbjct: 2351 NSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEI 2410
Query: 1212 LAPQNGLCNARFGS-AMEKSGKMDVAEALELSEKLYLDMSKTL--GSLMNIKNMSGHVSM 1268
+N L + +E+ K V + +L E L KT+ ++ + V
Sbjct: 2411 KELENLLSQEEEENIVLEEENKKAVDKTNQLMETL-----KTIKKENIQQKAQLDSFVKS 2465
Query: 1269 KYLSRQEREKV----NQLRQRDLDLVFDK---ITQLKNQLGRKEELLRGYEKDVEQL--R 1319
+ +R+++ QL +R L ++ +K I + + + +E +RG ++ L
Sbjct: 2466 MSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSE 2525
Query: 1320 RSKVSIEMYQ-----SQVAKLEDDIYKEAEEKAL-----LKEALERMEHQLCQEKRINRA 1369
+K+ E+ Q +QV ++D K+ E L L+ ++E +L + + N
Sbjct: 2526 NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANED 2585
Query: 1370 IRQQKVGTRKASLKMDQEREMLRKETSSKSSQ 1401
+R+ ++ + +E E L+ S + Q
Sbjct: 2586 LRRSFNALQEEKQDLSKEIESLKVSISQLTRQ 2617
Score = 129 bits (325), Expect = 2e-29
Identities = 259/1263 (20%), Positives = 514/1263 (40%), Gaps = 195/1263 (15%)
Query: 218 EEDLAQQDKDEIILL---LGKEVSRLSDY-EIESKYKDVIIANLQNEVAELSQKVSETTT 273
E + Q++ ++ LL + +E+SR++ E + KD + L N++AEL+ +
Sbjct: 1883 ELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYC- 1941
Query: 274 SRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKN 333
Q+ + K ++L+ ++ +K + L+ + L K +KV + E +I +
Sbjct: 1942 --QDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK 1999
Query: 334 EGENLKRDNAITSGM------VSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEAL 387
E N + + V LQKD + E++ L+ V L+ + LE
Sbjct: 2000 EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLE-- 2057
Query: 388 GSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRK-----SCTE 442
+ KE L Q HR+ +A EL K + D + E ++ A+ K +
Sbjct: 2058 -----ITKENLAQAVEHRKKAQA---ELASFKVLLDDTQSEAARVLADNLKLKKELQSNK 2109
Query: 443 QSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVI---KINLERAVGQLEHFRSQV 499
+SV S+ ++ +E +L++ + L + + M + + K++LE +G+++ ++
Sbjct: 2110 ESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKK 2169
Query: 500 IKATYGRAKPFRDKPVTDQQLIEKIT---QVTEDNINFQQKKWTLQKETQLSNSKQEETT 556
K + + D VT K Q D + + KKW +K + SK+EE
Sbjct: 2170 DKEVQ-QLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWE-RKFSDAIQSKEEE-- 2225
Query: 557 ENIEKLRTSLDSCQACM----KISCCSHDLKKEVDLLQHLQV-----SPPVSGLQKVVLD 607
+R D+C ++S +LK + L+H + + LQ+ V D
Sbjct: 2226 -----IRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD 2280
Query: 608 VL----RHALSWLEEVEQLLR----DLGILPSSPN--KDQVQQFSGNSAVFTAGKAAGAS 657
L + LS LEE L +L L S KDQ+ S + K
Sbjct: 2281 TLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKG---- 2336
Query: 658 GREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELES 717
EG + EA + S Q LE + R EE + Q++ S
Sbjct: 2337 NLEGIIRQQEADIQNSKFSYEQ----------LETDLQASRELTSRLHEEINMKEQKIIS 2386
Query: 718 LLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEAL 777
LL+ +++A+ +I E ++ ++ELE L++++E L
Sbjct: 2387 LLSGKEEAIQVAIA-------ELRQQHDKEIKELENLLSQEEE------------ENIVL 2427
Query: 778 ESEKRKVQDLENHLTQQ-KEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELEL 836
E E +K D N L + K I + NI +++ ++ K +Q+ +R+ ++LE
Sbjct: 2428 EEENKKAVDKTNQLMETLKTIKKENI--QQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEE 2485
Query: 837 KE-----QKEDVL------NNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELET 885
+ +K+ ++ NNKL + + + +E+ K ++ ++ E L ++ T
Sbjct: 2486 RHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVIT 2545
Query: 886 TKTKMIMVEERLILQQKMVKALQDEQ----ESQRHGFEEEIMEYKEQIKQHAQTIVSLEE 941
K QQK + +Q +Q E++ EE++ E +E + ++ +L+E
Sbjct: 2546 IKDS----------QQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQE 2595
Query: 942 KLQKVTQHHKKIEGEIATLKDNDPAPKEE-------------RPQDPLVAPMTESSAKDM 988
+ Q +++ + ++ I+ L A +EE + ++ + SS K +
Sbjct: 2596 EKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRI 2655
Query: 989 AYEHLIDDLLAAQKEILSQQ-EVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLV 1047
A L ++L+ QKE + E+ KL+K+L H +R E ++ E LV
Sbjct: 2656 A--ELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLV 2713
Query: 1048 QQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQT 1107
+ + K L V KE +++ ++ R + +L+ + R N E ++ RK +
Sbjct: 2714 EMEQKLLMVTKENKG-LTAQIQSFGRSMSSLQNS--------RDHANEELDELKRKYDAS 2764
Query: 1108 CDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKA 1167
Q+ + + ++ R++ AL A +
Sbjct: 2765 LKELAQL---------------------------KEQGLLNRERDALLSETAFSMNSTEE 2797
Query: 1168 RSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLSR--IEILAPQNGLCNARFGS 1225
S H + N+ L + + Q L D+ + + S+ + ++ L N
Sbjct: 2798 NSLSHLEKLNQQLLSKDEQLLHLSSQ--LEDSYNQVQSFSKAMASLQNERDHLWNELEKF 2855
Query: 1226 AMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQR 1285
+ GK A S + K + SL N ++ +K L +++ + Q+ Q
Sbjct: 2856 RKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDR----LLKELKNLQQQYL-QINQE 2910
Query: 1286 DLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVS--IEMYQSQVAKLEDDIYKEA 1343
++ LK QL ++ + ++ E+LR+ +S E++Q ++ K +I++
Sbjct: 2911 -----ITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERR 2965
Query: 1344 EEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSS-KSSQS 1402
++ L A+ + QL + + R +R T+ LK+ +R+ + ++S SQ+
Sbjct: 2966 MKEQYLM-AISDKDQQLSHLQNLIRELRSSSSQTQ--PLKVQYQRQASPETSASPDGSQN 3022
Query: 1403 LLH 1405
L++
Sbjct: 3023 LVY 3025
Score = 123 bits (309), Expect = 1e-27
Identities = 225/1176 (19%), Positives = 478/1176 (40%), Gaps = 169/1176 (14%)
Query: 296 QKEIQSLKSQISALQKGYSK---VLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSL 352
Q E++ LKSQI L+ + K + + L E+ EI++L E K++ S ++L
Sbjct: 683 QDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTAL 742
Query: 353 QKDILAKDEQVQQLKE--EVSHLKSQNKDKDHQL------EALGSRCSVLKEELKQEDAH 404
++ +D+ + Q+KE V+ L++Q K + L L + L E H
Sbjct: 743 SEE---RDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIH 799
Query: 405 RELREAQEKELKL---------CKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSK 455
EA+ K++K+ + Q + ++ L+++L+ +E + +R S
Sbjct: 800 SLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISS 859
Query: 456 VEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPV 515
E+L + +K L++ +M K ++E +E QV + ++
Sbjct: 860 KVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFS---------- 909
Query: 516 TDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEK-------LRTSLDS 568
+ EK+ Q+ E+ + + TL+++ L + +E E +E+ L+ + D
Sbjct: 910 ----MTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDE 965
Query: 569 CQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGI 628
+IS +L+ E DLL+ ++ + L + L+ V +L +L
Sbjct: 966 MSPAGQIS--KEELQHEFDLLKKENEQR-----KRKLQAALINRKELLQRVSRLEEELAN 1018
Query: 629 LPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGK 688
L K+ E ERGE E + ++ + +
Sbjct: 1019 LKDESKKEIPLS---------------------ETERGEVEEDKENKEYSEKCVTSKC-Q 1056
Query: 689 ALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRV 748
+E Y+ Q + + L+ RK ++E + +Q +AL K + Q L+++ ++
Sbjct: 1057 EIEIYLKQTISEKEVELQHIRKDLEE-KLAAEEQFQALVKQMNQ-------TLQDKTNQI 1108
Query: 749 QELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRK 808
L+ ++ + +++ I +A + + + ++ S + E +
Sbjct: 1109 DLLQAEISENQAIIQKLITSNT----DASDGDSVALVKETVVISPPCTGSSEHWKPELEE 1164
Query: 809 AKEAMEKEKKKVQD-LENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESL 867
A+EKEK+++Q L+ LT +K L+ ++KE L +L ++ + E
Sbjct: 1165 KILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQ-----QKDDYNRLQEQF 1219
Query: 868 KAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKE 927
+S K NE + + + + + ++ R + K+ Q E S G EE + + E
Sbjct: 1220 DEQS---KENENIGD----QLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATE 1272
Query: 928 QIKQHAQTIVSLEEKLQKVTQHHKK----IEG--EIATLKDNDPAPKEERPQDPLVAPMT 981
Q H Q + LE L H + ++G +A +K + E+ + L T
Sbjct: 1273 Q--HHTQPV--LESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSST 1328
Query: 982 ESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQ----- 1036
S + +++ Q++I Q I L+ EA L+ +L Q
Sbjct: 1329 TSELTKKS-----EEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAG 1383
Query: 1037 -------KMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKH 1089
+ +L++ L+ ++ +++S L ++++ + + K E+ E+ ++A +
Sbjct: 1384 LEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQL 1443
Query: 1090 RLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQR 1149
+Q E+ + + + C+ + E + E+ + Q Q+ + +
Sbjct: 1444 EMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKL------------QAALIS 1491
Query: 1150 QKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLSRI 1209
+K+AL E ++ +EL AR + +S D+++ N +K + L R+
Sbjct: 1492 RKEALKENKSLQEELSLARGTIER--LTKSLADVESQVSAQNKEKDTV--------LGRL 1541
Query: 1210 EILAPQNG-LCNARFGSAMEKSGKMDVAEALELS-EKLYLDMSKTLGSLMNIKNMSGHVS 1267
+L + L S +E E+L+L+ E L D K + + ++K S
Sbjct: 1542 ALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLK------S 1595
Query: 1268 MKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEM 1327
K E ++ ++ Q++ +++ + N+ R + ++ ++ ++L S E
Sbjct: 1596 SKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEA 1655
Query: 1328 YQSQVAKLEDDIYKEAEE-KALLKEALERMEHQLCQEKRINRAIR-------------QQ 1373
+ + K + +E EE K +++ + + ++ + + N +R +
Sbjct: 1656 NKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECME 1715
Query: 1374 KVGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPS 1409
+ + AS+K + ER + ET SK QSL+ K S
Sbjct: 1716 TLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDS 1751
Score = 110 bits (276), Expect = 7e-24
Identities = 235/1252 (18%), Positives = 506/1252 (40%), Gaps = 177/1252 (14%)
Query: 235 KEVSRLS----DYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDE 290
KE+S L+ +++ + L E +L +V E + + ++ Q L E
Sbjct: 716 KEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAE 775
Query: 291 DIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVS 350
++ + +S + + L + + + S ++ +I L+NE ++++ + S ++
Sbjct: 776 AERQRRLDYESQTAHDNLLTEQIHSLSIEAKS-KDVKIEVLQNELDDVQLQFSEQSTLIR 834
Query: 351 SLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEEL--KQEDAHRELR 408
SLQ + K+ +V + E V H+ S+ ++ L + + + L K+ D +
Sbjct: 835 SLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQ 894
Query: 409 EAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKL 468
+EK+ Q+ ++ M + +L + V +TL+E+ + + +E +
Sbjct: 895 TIEEKD-----QQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKE-- 947
Query: 469 LQLQEMGNRESVIKINLERA--VGQ-----LEHFRSQVIKATYGRAKPFRDKPVTDQQLI 521
Q++E S +K N + GQ L+H + K R + + + ++L+
Sbjct: 948 -QVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELL 1006
Query: 522 EKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHD 581
++++++ E+ N + + +KE LS +++ E E+ E S + C+ C
Sbjct: 1007 QRVSRLEEELANLKDES---KKEIPLSETERGEVEEDKENKEYS----EKCVTSKC---- 1055
Query: 582 LKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLG-ILPSSPNKDQVQQ 640
+E+++ +S LQ + D L L+ E+ + L++ + L N+ + Q
Sbjct: 1056 --QEIEIYLKQTISEKEVELQHIRKD-LEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQ 1112
Query: 641 --FSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKA-LEEYITQE 697
S N A+ + +G++ A + T E K LEE I
Sbjct: 1113 AEISENQAIIQKLITSNTDASDGDSV---ALVKETVVISPPCTGSSEHWKPELEEKIL-- 1167
Query: 698 RNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQ---TRVQELEER 754
LE+E++++Q+ +KA+ K +++ ++E L++++ R+QE +
Sbjct: 1168 ------ALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDE 1221
Query: 755 LARQKEVLESSIAHEKRKAKEALES-----------------EKRKVQDLENHLTQQKEI 797
+++ E + + + + +E+++ E+ + E H TQ +
Sbjct: 1222 QSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQ--PV 1279
Query: 798 SESN--------------------IAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELK 837
ESN +A K + KE +E EK +LE +++ EL K
Sbjct: 1280 LESNLCPDWPSHSEDASALQGGTSVAQIKAQLKE-IEAEK---VELELKVSSTTSELTKK 1335
Query: 838 EQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNET------LAELETTKTKMI 891
++ L +++ +E + + AESL KL + L L + K+
Sbjct: 1336 SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLD 1395
Query: 892 MVEERLILQQKMVKALQ---DEQESQRHGFEEEIMEYKEQIKQ-HAQTIVSLEEKLQKVT 947
+++ + +++ V L E+E+ + EI+E ++ IK H Q LE + ++
Sbjct: 1396 ELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQ----LEMQAKEHD 1451
Query: 948 QHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQ 1007
+ K+++ E+ +K EE + +++ ++ + + + + Q+E+
Sbjct: 1452 ERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAAL--ISRKEALKENKSLQEELSLA 1509
Query: 1008 QEVIMKLRKDLTEAHSRMSDLRGELN-----------EKQKMELEQNVVLVQQQSKELSV 1056
+ I +L K L + S++S E + E+ K+ E + L++ QS S
Sbjct: 1510 RGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSC 1569
Query: 1057 LKEKMAQMSSLVEKKDRELKALEEALRAS--------QEKHRLQLNTEKEQKPRKKTQTC 1108
K+A + L E K++ +K + E+L++S QEKH+ +L E E +
Sbjct: 1570 ESLKLA-LEGLTEDKEKLVKEI-ESLKSSKIAESTEWQEKHK-ELQKEYEILLQSYENVS 1626
Query: 1109 DTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKAR 1168
+ + +I+ V EA +++ E+ +Q ++ + E++ ++++ K++
Sbjct: 1627 NEAERIQHV-VEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSK 1685
Query: 1169 SPDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAME 1228
Q L+ +N R+ V AK + TL
Sbjct: 1686 ------QQKILELEEENDRLRAEVHPAGDTAKECMETL---------------------- 1717
Query: 1229 KSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSG-------HVSMKYLSRQEREKVNQ 1281
S + E LE + Y +SK SLM+ K+ H +S+Q + +
Sbjct: 1718 LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATE 1777
Query: 1282 LRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYK 1341
++ + + + ++ L + S S S+ D+I
Sbjct: 1778 KHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINN 1837
Query: 1342 EAEEKALLKEALERMEHQLCQEKRINRAIRQQK------VGTRKASLKMDQE 1387
++ LKE + +E + + K ++ + +K + T+ LKM QE
Sbjct: 1838 YLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQE 1889
Score = 106 bits (264), Expect = 2e-22
Identities = 251/1361 (18%), Positives = 570/1361 (41%), Gaps = 226/1361 (16%)
Query: 224 QDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQ 283
Q+K+E I L ++S+ + + A + +V ++ + T E E+ Q
Sbjct: 193 QEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQ 252
Query: 284 KCQVLDEDIDAKQKEIQSLKSQISALQKGYS------KVLCQTLSERNSEITSLKNEGEN 337
K +VL ++ ++ + + LQ+ + ++L Q L + +E +L+N E
Sbjct: 253 KLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVET 312
Query: 338 LKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEE 397
+ ++ I ++ ++ ++ + L+EE+ HL Q + L SR S L+++
Sbjct: 313 EREESKI---LLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQK 369
Query: 398 LKQEDAHRELREAQEKELKLCKT--QIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSK 455
K E+ E L L KT ++Q +K ++L + EQ+V ++ + +
Sbjct: 370 HK-----AEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAV--QSAQTIQQ 422
Query: 456 VEEKLQEDSR-------RKLLQLQEMGNRESVIKI--------------NLERAVGQLEH 494
+E++LQ+ S+ R LQ E ++ S + +L++ V +LE+
Sbjct: 423 LEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELEN 482
Query: 495 FRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQ-KETQLSNSKQE 553
+ ++ ++ + +++L +IT + N + + + ++N +
Sbjct: 483 EKGALLLSSI----ELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSS 538
Query: 554 ETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVL-RHA 612
E+ + + + S Q ++S ++K+ + + L++ ++ +VL +
Sbjct: 539 SAEESGQDVLENTFS-QKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKE 597
Query: 613 LSWLE-------EVEQLLRDLG-ILPSSPNK--------------DQVQQFSGNSAVFTA 650
+ +E +++ L D G P PN+ + + S ++ A
Sbjct: 598 MKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDA 657
Query: 651 GKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERK 710
G ++ ++G+ G+ Q++ + LE + + ++ L+E+ K
Sbjct: 658 GVELKSTKQDGDKSLSAVPDIGQCH-QDELERLKSQILELELNFHKAQEIYEKNLDEKAK 716
Query: 711 RMQELESLLAQQKK----------ALAKSITQEKNRVKE--ALEEEQTRVQELEERLA-- 756
+ L L+ + KK AL++ Q ++VKE + E + +V++LE LA
Sbjct: 717 EISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEA 776
Query: 757 -RQKEV-LESSIAHE------------KRKAKEA-LESEKRKVQDLENHLTQQKEISESN 801
RQ+ + ES AH+ + K+K+ +E + ++ D++ ++Q + S
Sbjct: 777 ERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSL 836
Query: 802 IAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKT 861
+ + K E +E ++V+ + +++ + + L KE + ++ L + VE Q+T
Sbjct: 837 QSQLQNKESEVLE-GAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQT 895
Query: 862 KATESLKAESLALKLNETLAELETTK----TKMIMVEERLILQQKMVKALQDE------- 910
+ + ++ + E + +L K ++ ++E+L L + +A +++
Sbjct: 896 IEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEV 955
Query: 911 ------------------QESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKK 952
+E +H F+ E +++ ++ +++ +E LQ+V+ +
Sbjct: 956 SSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVS----R 1011
Query: 953 IEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQ-QEVI 1011
+E E+A LKD K+E P E ++ Y ++K + S+ QE+
Sbjct: 1012 LEEELANLKDES---KKEIPLSETERGEVEEDKENKEY---------SEKCVTSKCQEIE 1059
Query: 1012 MKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQ-------QSKELSVLKEKMAQM 1064
+ L++ ++E + +R +L EK E EQ LV+Q ++ ++ +L+ ++++
Sbjct: 1060 IYLKQTISEKEVELQHIRKDLEEKLAAE-EQFQALVKQMNQTLQDKTNQIDLLQAEISEN 1118
Query: 1065 SSLVEK--------KDRELKAL--------------EEALRASQEKHRLQLNTEKEQKPR 1102
++++K D + AL E + E+ L L EKEQ +
Sbjct: 1119 QAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQK 1178
Query: 1103 K--KTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKK-------A 1153
K + T ++ + E + +Q D +R +E Q K
Sbjct: 1179 KLQEALTSRKAILKKAQEKERHLREELKQQKDDY------NRLQEQFDEQSKENENIGDQ 1232
Query: 1154 LSELRARIKELEKARSPDHKDHQNESFL-----DLKNLRMENNVQKIL-LDAKPDLPTLS 1207
L +L+ +++E + P ++ S L +++ Q +L + PD P+ S
Sbjct: 1233 LRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHS 1292
Query: 1208 RIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSE-------------KLYLDMSKTLG 1254
+ A Q G A+ + +++ V L++S +L ++K
Sbjct: 1293 E-DASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGL 1351
Query: 1255 SLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKD 1314
+ ++K +S + S Q++ + +QL+ L + + +L+ +L ++L+ E+D
Sbjct: 1352 EIESLKTVSHEAEVHAESLQQKLESSQLQIAGL----EHLRELQPKLDELQKLISKKEED 1407
Query: 1315 VE----QLRRSKVSIEMYQSQVAKLED---DIYKEAEEKAL-LKEALERMEHQLCQEKR- 1365
V QL + ++ Q+++ + ED ++ + E +A E +++++ +LC+ K+
Sbjct: 1408 VSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQK 1467
Query: 1366 ---INRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSL 1403
I R ++ RK + +E L++ S + SL
Sbjct: 1468 PEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSL 1508
Score = 98.6 bits (244), Expect = 4e-20
Identities = 217/1135 (19%), Positives = 460/1135 (40%), Gaps = 174/1135 (15%)
Query: 384 LEALGSRCSVLKEELKQEDAHRELREA-------QEKELKLCKTQIQDMEKEM---KKLR 433
L L +V+ EL +D + A QE +++ T +D+++ + ++L
Sbjct: 2 LSRLSGLANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLV 61
Query: 434 AELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLE 493
EL K Q + ++++ EE+ D++ K L+L S+ K E
Sbjct: 62 VEL-KDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEE------- 113
Query: 494 HFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQE 553
+KA G P +P +++QL + TE+ + ++ K LQ++ +L ++ Q
Sbjct: 114 ------MKAQGGTVLP--TEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQA 165
Query: 554 ETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHAL 613
+ T+ + S + L+++ + + LQ + ++ V+R
Sbjct: 166 QLTQ--AQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKD 223
Query: 614 SWLEEVEQLLRD--LGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARAR 671
+ E +L D L ++ + + ++QQ + + E E
Sbjct: 224 ARFETQVRLHEDELLQLVTQADVETEMQQ--------------KLRVLQRKLEEHEESLV 269
Query: 672 GEAQ----SQNQATDGREGGKALEEYITQ---ERNRAKETLE---EERKRMQELESLLAQ 721
G AQ Q + T + + L + + Q E N + T+E EE K + E L
Sbjct: 270 GRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVA 329
Query: 722 QKKALAKSITQEKNRVKEALEEEQTRVQELEERLA----RQKEVLESSIAH--EKRKAKE 775
++K ++ +E + + E E+ ELE R + + K +E +H +K +
Sbjct: 330 ERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQ 389
Query: 776 ALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELE 835
L+S ++D + L Q K A ++ ++ ++++ K++ NRL Q+ E
Sbjct: 390 ELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETA 449
Query: 836 LKEQKEDVLN--------NKLSDALAMVEETQKTKAT--------ESLKAESLALKLNET 879
+ DV N ++ V E + K E LKAE+ L T
Sbjct: 450 SQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQIT 509
Query: 880 L---------AELETTKTKMI-MVEERLILQQKMVKALQDEQESQRH-GFEEEIMEYKEQ 928
L A+ E ++ ++ + +R ++ + + + SQ+H ++E KE
Sbjct: 510 LLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEA 569
Query: 929 IKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAP------KEERPQDPLVAPMTE 982
++ A + L+ K + H + E+ ++ AP E+ QD + P E
Sbjct: 570 QEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEE 629
Query: 983 SSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDL-------RGELN-- 1033
SS + E + + E +S + ++L+ + +S + + EL
Sbjct: 630 SSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERL 689
Query: 1034 EKQKMELEQNVVLVQ--------QQSKELSVLKEKMAQ-----------MSSLVEKKDRE 1074
+ Q +ELE N Q +++KE+S L + + + ++L E++D+
Sbjct: 690 KSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQL 749
Query: 1075 LKALEEALRASQ---EKHRLQLNTEKEQKPRK---KTQTCDTSVQIEPVHTEAFSSSQEQ 1128
L ++E ++ + +L++N + ++ R+ ++QT ++ E +H+ + + +
Sbjct: 750 LSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKD 809
Query: 1129 QSFSDL-----GVRCKGSRHEEVIQRQKKALSELRARIKE-LEKARSPDHKDHQNESFLD 1182
L V+ + S +I+ + L + + E E+ R K + L
Sbjct: 810 VKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALS 869
Query: 1183 LKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELS 1242
K L + + ++LL+ K D+ TL + +E+ + + ++
Sbjct: 870 QKELEI-TKMDQLLLEKKRDVETLQQ-----------------TIEEKDQQVTEISFSMT 911
Query: 1243 EKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRD-----LDLVFDKITQL 1297
EK+ + + IK + +++ LSR E K Q+ + + L +D+++
Sbjct: 912 EKMVQLNEEKFSLGVEIKTLKEQLNL--LSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPA 969
Query: 1298 ----KNQLGRKEELL-RGYEKDVEQLRRSKVSIEMYQSQVAKLEDDI--YKEAEEKALLK 1350
K +L + +LL + E+ +L+ + ++ + +V++LE+++ K+ +K +
Sbjct: 970 GQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPL 1029
Query: 1351 EALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQSLLH 1405
ER E +E + N+ ++ V ++ QE E+ K+T S+ L H
Sbjct: 1030 SETERGE---VEEDKENKEYSEKCVTSK------CQEIEIYLKQTISEKEVELQH 1075
Score = 94.7 bits (234), Expect = 5e-19
Identities = 274/1308 (20%), Positives = 546/1308 (41%), Gaps = 234/1308 (17%)
Query: 213 AEIYVEEDLAQQDKDEIILL-LGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSET 271
A + + E D D+ + L E+ + SD E + ++ ++Q +A Q V E
Sbjct: 9 ANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQE----DVQERLAYAEQLVVEL 64
Query: 272 TTS-RQNEKEISQKCQVLDEDIDAKQKEIQSLK----SQISALQKGYSKVLCQ------- 319
RQ + ++ QK + L E+ A +I+ LK +++++L K ++ Q
Sbjct: 65 KDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPT 124
Query: 320 ------TLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDIL-AKDEQVQQLKEEVSH 372
LS+ + T + E E +K ++S+LQ + A+ EQ Q E+
Sbjct: 125 EPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEE 184
Query: 373 ---LKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEM 429
+K Q ++K+ + S L+ +L Q A + ++ ++ +TQ++ E E+
Sbjct: 185 FVMMKQQLQEKEEFI-------STLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDEL 237
Query: 430 KKL--RAELRKSCTEQ-SVISRTLRE-------KSKVEEKLQE-----DSRRKLL--QLQ 472
+L +A++ ++ V+ R L E +++V + LQ+ + R ++L QLQ
Sbjct: 238 LQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQ 297
Query: 473 EMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNI 532
+M + ++ +E + + ++ R F + L+E+ Q +
Sbjct: 298 QMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQA 357
Query: 533 NFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHL 592
+ + L+ Q ++ EE T +I L+ + +L+ D L+
Sbjct: 358 ELESRYSALE---QKHKAEMEEKTSHILSLQKT-------------GQELQSACDALKDQ 401
Query: 593 QVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGK 652
K++ D A+ + ++QL +DQ+QQ S + F
Sbjct: 402 N--------SKLLQDKNEQAVQSAQTIQQL------------EDQLQQKSKEISQFL--- 438
Query: 653 AAGASGREGEAERGEARARGEAQSQNQATD-GREGGKAL-EEYITQERNRAKETLEEERK 710
+ E SQ D EG +A+ EE I + R E LE E+
Sbjct: 439 ------------NRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVE-LENEKG 485
Query: 711 RMQ----ELESLLAQQKKALAK-SITQEKNRVKEALEE--EQTRVQELEERLARQKE--- 760
+ ELE L A+ +K ++ ++ + +NR EA E E + V +R + +E
Sbjct: 486 ALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQ 545
Query: 761 -VLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEA-----ME 814
VLE++ + +K K L E ++ Q+ EI+ + + ++A+EA +
Sbjct: 546 DVLENTFS-QKHKELSVLLLEMKEAQE---------EIAFLKLQLQGKRAEEADHEVLDQ 595
Query: 815 KEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLAL 874
KE K+++ K K LE Q ++ N+ S +L VE+ Q + +S +E ++
Sbjct: 596 KEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEES-SLPAVEKEQASTEHQSRTSEEIS- 653
Query: 875 KLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQ 934
LN+ EL++TK ++ L + + QDE E + +I+E + + AQ
Sbjct: 654 -LNDAGVELKSTKQD---GDKSLSAVPDIGQCHQDELER----LKSQILELELNFHK-AQ 704
Query: 935 TIV--SLEEKLQKVTQHHKKIEGEIATLKDND----PAPKEERPQDPLVAPMTESSAKDM 988
I +L+EK ++++ ++ IE E DN+ A EER D L++ + E S
Sbjct: 705 EIYEKNLDEKAKEISNLNQLIE-EFKKNADNNSSAFTALSEER--DQLLSQVKELS---- 757
Query: 989 AYEHLIDDLLAAQKEI---LSQQEVIMKLRKDLTEAHS-------------------RMS 1026
++ +L A K++ L++ E +L + AH ++
Sbjct: 758 ----MVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIE 813
Query: 1027 DLRGELNEKQKMELEQNVVL----VQQQSKELSVLK---------EKMAQMSSLVEKKDR 1073
L+ EL++ Q EQ+ ++ Q Q+KE VL+ K+ ++S + +K+
Sbjct: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKEL 873
Query: 1074 ELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSD 1133
E+ +++ L + T +E+ + + + ++ ++ E FS E ++ +
Sbjct: 874 EITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKE 933
Query: 1134 ---LGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNE-SFLDLKNLRME 1189
L R + ++ E+V + + S L+ E+ A ++ Q+E L +N + +
Sbjct: 934 QLNLLSRAEEAKKEQV-EEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRK 992
Query: 1190 NNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAME------KSGKMDV-AEALELS 1242
+Q L++ K L +SR+E L N + S E + G+++ E E S
Sbjct: 993 RKLQAALINRKELLQRVSRLE-----EELANLKDESKKEIPLSETERGEVEEDKENKEYS 1047
Query: 1243 EKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLG 1302
EK + + + V ++++ + EK+ + + ++ Q
Sbjct: 1048 EKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKL--AAEEQFQALVKQMNQTLQDKT 1105
Query: 1303 RKEELLRGYEKDVEQLRRSKVSIEMYQS---QVAKLEDDIY-------------KEAEEK 1346
+ +LL+ + + + + ++ S VA +++ + E EEK
Sbjct: 1106 NQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEK 1165
Query: 1347 ALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKE 1394
L ALE+ + QL +K++ A+ +K +KA K RE L+++
Sbjct: 1166 IL---ALEKEKEQL--QKKLQEALTSRKAILKKAQEKERHLREELKQQ 1208
Score = 55.8 bits (133), Expect = 3e-07
Identities = 122/624 (19%), Positives = 250/624 (40%), Gaps = 75/624 (12%)
Query: 256 NLQNEVAELSQKVSETT---TSRQNEKEIS---QKCQVLDEDI-------DAKQKEIQSL 302
+L E+ L +S+ T T+ Q E + + +V +E++ + QK I L
Sbjct: 2599 DLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAEL 2658
Query: 303 KSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQ 362
+ ++ +QK +K + + + E+ L ++ ++ + V+ L +D++ +++
Sbjct: 2659 EEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQK 2718
Query: 363 VQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQ- 421
+ + +E L +Q + + +L + EEL D + +A KEL K Q
Sbjct: 2719 LLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEEL---DELKRKYDASLKELAQLKEQG 2775
Query: 422 IQDMEKEMKKLRAELRKSCTEQSVISRTLREK----SKVEEKLQEDSRRK--LLQLQEMG 475
+ + E++ + TE++ +S + SK E+ L S+ + Q+Q
Sbjct: 2776 LLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFS 2835
Query: 476 NRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQ 535
+ ++ + +LE FR A+P P Q L + ++ + D
Sbjct: 2836 KAMASLQNERDHLWNELEKFRKSEEGKQRSAAQP-STSPAEVQSLKKAMSSLQNDRDRLL 2894
Query: 536 QKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMK-ISCCSHDLKKEVDLLQHLQV 594
++ LQ++ N +E TE + L+ L Q K +L++E QH
Sbjct: 2895 KELKNLQQQYLQIN---QEITE-LHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQH--- 2947
Query: 595 SPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAA 654
L LR S E E+ +++ ++ S D+ QQ S + +++
Sbjct: 2948 ----------ELHQLRMEKSSWEIHERRMKEQYLMAIS---DKDQQLSHLQNLIRELRSS 2994
Query: 655 GASGREGEAERGEARARGEAQSQNQAT-DGREGGKALEEYITQERNRAKETLEEERKRMQ 713
+ + + + + + +A + A+ DG + E + + N + + + ++ R+Q
Sbjct: 2995 SS-----QTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQ 3049
Query: 714 ELESLLAQQKKALAKSITQEKNRV-------KEALEEEQTRVQELEERLA-RQKEVLESS 765
+L S +Q + +EKN + ++L E Q +L A +K+V E
Sbjct: 3050 QLNSNFSQ--------LLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQ 3101
Query: 766 IAHEKRKAKEALESEKRKV---QDLENHLTQQKEISES-----NIAYEKRKAKEAMEKEK 817
EK V D E Q+ SE+ N E + ++ +E+E+
Sbjct: 3102 AGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEER 3161
Query: 818 KKVQDLENRLTKQKEELELKEQKE 841
+ EN L+ +E++ E E
Sbjct: 3162 DQRVAAENALSVAEEQIRRLEHSE 3185
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 130 bits (326), Expect = 1e-29
Identities = 248/1223 (20%), Positives = 509/1223 (41%), Gaps = 211/1223 (17%)
Query: 224 QDKDEIILLLGKEVSRLSDY--EIESKY---KDVI--IANLQNEVAELSQKVSETTTSRQ 276
Q+ + ++ ++V L D E+ES++ KD + + NL+ ++ +Q + + +
Sbjct: 321 QENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHER 380
Query: 277 NEKEISQKCQVLDEDIDAKQKE---IQSLKSQISALQKGYSKVLCQTLSERNSEITSLKN 333
+ E ++E + AK+++ I+ LKS+++ L K + C T+ + N E+ SLK
Sbjct: 381 EDLEFK-----INELLLAKEEQGCVIEKLKSELAGLNKQF----CYTVEQHNREVQSLKE 431
Query: 334 EGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSV 393
+ + K + + +S +K+ L ++Q LKE+ +L+ + ++ E+L +
Sbjct: 432 QHQ--KEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEI 489
Query: 394 LKEEL--------------KQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKS 439
L+ EL KQ+ A ++ E Q+K L+ T+ + + + +L+ E K
Sbjct: 490 LQTELGESAGKISQEFESMKQQQAS-DVHELQQK-LRTAFTEKDALLETVNRLQGENEKL 547
Query: 440 CTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQV 499
++Q ++ E + LQE + LL L + R++++K LE + L +
Sbjct: 548 LSQQELVP----ELENTIKNLQEKNGVYLLSLSQ---RDTMLK-ELEGKINSLTEEKDDF 599
Query: 500 I---KATYGRAKPFRDKPVTDQQLI----EKITQVTEDNINFQQKKWTLQKETQLSNSKQ 552
I K ++ F K +++LI +K+ Q + N +QK L + + ++
Sbjct: 600 INKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEK 659
Query: 553 EETTENIEKLRTSL-----DSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLD 607
++ + +EKL + D ++ + K + L V QK +
Sbjct: 660 DQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVI 719
Query: 608 VLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAER-- 665
+ H ++++ ++ + L +QVQ+ + ++ K G+ E E+
Sbjct: 720 LKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDV 779
Query: 666 -------GEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESL 718
GE+ A+ + N A E K LE LE+E K +QE +
Sbjct: 780 VNVLQAVGESLAKINEEKCNLAFQRDE--KVLE-------------LEKEIKCLQEESVV 824
Query: 719 LAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRK------ 772
++ K+L + QEK +++ LEE Q+ E+ A Q ++LE A+EK +
Sbjct: 825 QCEELKSLLRDYEQEKVLLRKELEEIQS------EKEALQSDLLEMKNANEKTRLENQNL 878
Query: 773 -----------AKEALESEKRK--VQDLEN--HLTQQKEISESN---IAYEKRKAKEAME 814
+K + +EK K +++ EN L +QKE+ + I + AK
Sbjct: 879 LIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSV 938
Query: 815 KEK--KKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESL 872
K V++LE ++ + E E KE++E + KL A E K T+++K E
Sbjct: 939 KNDPLSSVKELEEKI--ENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELE 996
Query: 873 ALKLNETLAELETTKTKMIMVEE---RLILQQKMVKALQDEQESQRHGFEEEIMEYKEQI 929
+L+ + +L + +I E L+L+ + D ++ + + FE I + Q+
Sbjct: 997 SLRSEKD--QLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQL 1054
Query: 930 K-------------------------------------QHAQTIVSLE---EKLQKVTQH 949
+ Q A+ +V E EKLQK Q
Sbjct: 1055 RNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQK-EQK 1113
Query: 950 HKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQE 1009
K+ + L++ ++E+ Q E KD L++ EI +
Sbjct: 1114 IKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMN------MEIADYER 1167
Query: 1010 VIMKLRKDLTEAHSRMSDLRGELN-EKQKME-LEQNVVLVQQQSKELSVLKEKMAQMSSL 1067
++ +L + LT ++++ DL E+ +KQK E L++ + +Q ++ K+ Q+
Sbjct: 1168 LMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVK 1227
Query: 1068 VEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQE 1127
+K+ + K E Q + +L ++Q K Q + + + +H +S+++
Sbjct: 1228 TKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQ 1287
Query: 1128 --------QQSFSDLGVRCKGSRHEEVIQRQKKALSELRA-------RIKELEKARSPDH 1172
QQ + L C+ ++ E+ + ++R + K + +A +
Sbjct: 1288 HQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGA 1347
Query: 1173 KDHQN--ESFLDLKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKS 1230
K + E +D ++++++ + ++ +S ++ L ++ R ++++
Sbjct: 1348 KQEREHLEMLIDQLKIKLQDSQNNLQIN-------VSELQTLQSEHDTLLERHNKMLQET 1400
Query: 1231 GKMDVAEALELSEKLYLDMSKT-------------LGSLMNIKNMSGHVSMKYLSRQERE 1277
V++ EL EKL S+ L S + S +++L + R+
Sbjct: 1401 ----VSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRK 1456
Query: 1278 KVNQLRQRDLDLVFDKITQLKNQ 1300
V L+Q+ L + ++ QLKN+
Sbjct: 1457 TVETLQQQ-LSKMEAQLFQLKNE 1478
Score = 122 bits (307), Expect = 2e-27
Identities = 275/1223 (22%), Positives = 502/1223 (41%), Gaps = 198/1223 (16%)
Query: 244 EIESKYKDVI--IANLQNEVAELSQKVSETTTSRQNEKEISQKCQV-LDEDI---DAKQK 297
E+E + + + I NL+NE+ + K SE + Q + E + Q+ L E + + +
Sbjct: 119 ELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSED 178
Query: 298 EIQSLKSQISALQKGYS-------KVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVS 350
++ L+ +I ++ G+ K L T E+ +T L+N I
Sbjct: 179 NVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQN----------IIEANSQ 228
Query: 351 SLQKDILAKDEQVQQLK----EEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRE 406
QK+I + E++ QLK EEV L Q + + EA ++ + LKE L ++
Sbjct: 229 HYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQC---- 284
Query: 407 LREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRR 466
EA EK ++ + E E++ LR + + + S L+E + VE+ + E +
Sbjct: 285 --EASEKNIQ------KKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKH 336
Query: 467 KLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQ 526
L+E+ ++ S++K ++ + + +K +E Q
Sbjct: 337 LEDTLKELESQHSILK-------DEVTYMNNLKLK-------------------LEMDAQ 370
Query: 527 VTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEV 586
+D F +++ K +L +K+E+ IEKL++ L + H+ +EV
Sbjct: 371 HIKDEF-FHEREDLEFKINELLLAKEEQGCV-IEKLKSELAGLNKQFCYTVEQHN--REV 426
Query: 587 DLLQHLQVSPPVSGLQKVVL-DVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNS 645
L+ Q +S L + L D + L+ + E++ L L + + S
Sbjct: 427 QSLKE-QHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLRE 485
Query: 646 AVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETL 705
+ G S G+ E+ Q QA+D E + L T+ K+ L
Sbjct: 486 IMEILQTELGESA-------GKISQEFESMKQQQASDVHELQQKLRTAFTE-----KDAL 533
Query: 706 EEERKRMQ-ELESLLAQQKKALAKSIT----QEKNRVKE-ALEEEQTRVQELEERLARQK 759
E R+Q E E LL+QQ+ T QEKN V +L + T ++ELE ++
Sbjct: 534 LETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLT 593
Query: 760 EVLESSI-----AHEK---------RKAKEALESEKRKVQDLENHLTQQKEISESNIAYE 805
E + I +HE+ R+ + LE K+ Q ++ + +++++E E
Sbjct: 594 EEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLE 653
Query: 806 KR-KAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKAT 864
+ K K+ +++ +K+ L++ KE L + + NNKLS E+ Q ++
Sbjct: 654 ETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSS-----EKKQLSRDL 708
Query: 865 ESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQ------ESQRHGF 918
E ++ + L E + +LE K +MVEE Q + K L++EQ ++Q +GF
Sbjct: 709 EVFLSQKEDVILKEHITQLE--KKLQLMVEE----QDNLNKLLENEQVQKLFVKTQLYGF 762
Query: 919 EEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVA 978
+E+ + + + LQ V + KI E K N ++E+ +
Sbjct: 763 LKEMGSEVSEDSEEKDVV----NVLQAVGESLAKINEE----KCNLAFQRDEKVLE---- 810
Query: 979 PMTESSAKDMAYEHLID-DLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGEL----- 1032
E K + E ++ + L + Q++V+ LRK+L E S L+ +L
Sbjct: 811 --LEKEIKCLQEESVVQCEELKSLLRDYEQEKVL--LRKELEEIQSEKEALQSDLLEMKN 866
Query: 1033 -NEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRL 1091
NEK ++E + ++ V++ S+ S E + K+ LK L E + L
Sbjct: 867 ANEKTRLENQNLLIQVEEVSQTCSK-SEIHNEKEKCFIKEHENLKPLLEQKELRDRRAEL 925
Query: 1092 QLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQK 1151
L + K SV+ +P+ S + ++ +L CK EE I + K
Sbjct: 926 ILLKDSLAK--------SPSVKNDPLS----SVKELEEKIENLEKECK--EKEEKINKIK 971
Query: 1152 ----KALSELRARIKE-------LEKARSPDHKDHQNESFLDL-------KNLRMENNVQ 1193
KA EL + KE LE RS KD + S DL KNL +E Q
Sbjct: 972 LVAVKAKKELDSSRKETQTVKEELESLRS--EKDQLSASMRDLIQGAESYKNLLLEYEKQ 1029
Query: 1194 KILLDAKPDLPTL--SRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSK 1251
LD + + RIE L Q L N+ S D+ +E + +
Sbjct: 1030 SEQLDVEKERANNFEHRIEDLTRQ--LRNSTLQCETINSDNEDLLARIETLQSNAKLLEV 1087
Query: 1252 TLGSLMNIKNM-SGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRG 1310
+ + K M + + L ++++ K + +L+ + ++ + K QL + + L
Sbjct: 1088 QILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELEL 1147
Query: 1311 YEKDVEQLRRSKVSIEMYQ--------------SQVAKLEDDIYKEAEEKALLKEALERM 1356
+KD +Q + I Y+ +++ LE +I + +++ L+E + +
Sbjct: 1148 VKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSL 1207
Query: 1357 EHQLCQEKRINRAIRQQKVGTRK 1379
+ + Q + N I+Q V T+K
Sbjct: 1208 QSSVQQYEEKNTKIKQLLVKTKK 1230
Score = 72.0 bits (175), Expect = 4e-12
Identities = 174/823 (21%), Positives = 322/823 (39%), Gaps = 168/823 (20%)
Query: 687 GKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEE--- 743
G A +E N KE +E + + + S ++ K L K + + N E E+
Sbjct: 114 GDAHKELEQSHINYVKE-IENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKF 172
Query: 744 ---EQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISES 800
+ V++L+E + + + E I + +++ + +K V L+N + + +
Sbjct: 173 QNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQK 232
Query: 801 NI-----------AYEKRKAKEAM----------EKEKKKVQDLENRLTKQKEELELKEQ 839
NI A + + KE M E E K+ +L+ L KQ E E Q
Sbjct: 233 NINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQ 292
Query: 840 K---------------------------------EDVLNNK---LSDALAMVEETQKTKA 863
K E V+N K L D L +E
Sbjct: 293 KKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILK 352
Query: 864 TESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKAL--QDEQESQRHGFEEE 921
E +L LKL E++ K ER L+ K+ + L ++EQ + E
Sbjct: 353 DEVTYMNNLKLKL-----EMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSE 407
Query: 922 IMEYKEQ----IKQHAQTIVSLEEKLQKVTQHHKKI-----EGEIATLKDNDPAPKEE-- 970
+ +Q ++QH + + SL+E+ QK + E E TL KE+
Sbjct: 408 LAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCE 467
Query: 971 -RPQDPLVAPMTESSAKDMAYEHLIDDL------LAAQKEILSQQ------EVIMKLRKD 1017
Q+ A + S +++ E L +L ++ + E + QQ E+ KLR
Sbjct: 468 NLQQEKQEAILNYESLREI-MEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTA 526
Query: 1018 LTEAHSRMSDLRGELNEKQKM--------ELEQNVVLVQQQ--------SKELSVLKEKM 1061
TE + + + E +K+ ELE + +Q++ S+ ++LKE
Sbjct: 527 FTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELE 586
Query: 1062 AQMSSLVEKKDRELKALEEALRASQEKHR-------------------LQLNTEKEQKPR 1102
+++SL E+KD + L+ + H+ +Q N+E EQK
Sbjct: 587 GKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVN 646
Query: 1103 KKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKG-SRHEEVIQRQKKALSELRARI 1161
+ T + +++ Q Q L V+ K S +EV+ + K+L E ++
Sbjct: 647 ELTGGLEETLK---------EKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKL 697
Query: 1162 KELEKARSPDHKD--HQNESFLDLKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGLC 1219
+K S D + Q E + +++ +++++ + +L L +E Q
Sbjct: 698 SSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKL--LENEQVQKLFV 755
Query: 1220 NARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLG-SLMNIKNMSGHVSMKYLSRQEREK 1278
+ +++ G +V+E E EK +++ + +G SL I + L+ Q EK
Sbjct: 756 KTQLYGFLKEMGS-EVSEDSE--EKDVVNVLQAVGESLAKINEEKCN-----LAFQRDEK 807
Query: 1279 VNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDD 1338
V +L + L + + Q + + LLR YE++ LR+ +E QS+ L+ D
Sbjct: 808 VLELEKEIKCLQEESVVQCE----ELKSLLRDYEQEKVLLRK---ELEEIQSEKEALQSD 860
Query: 1339 I--YKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRK 1379
+ K A EK L+ ++ L Q + +++ + ++ K
Sbjct: 861 LLEMKNANEKTRLEN-----QNLLIQVEEVSQTCSKSEIHNEK 898
Score = 63.5 bits (153), Expect = 1e-09
Identities = 133/731 (18%), Positives = 289/731 (39%), Gaps = 101/731 (13%)
Query: 179 DDARKPPVIKQVWTNAMKLSEKSVAEGIPGAVPPAEIYVEEDLAQQDK--DEIILLLGKE 236
D K P +K +++K E+ + +E++ ++++ ++I L+ K
Sbjct: 930 DSLAKSPSVKNDPLSSVKELEEKIEN------------LEKECKEKEEKINKIKLVAVKA 977
Query: 237 VSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQ 296
L E++ + +L++E +LS + + ++ K + + + E +D ++
Sbjct: 978 KKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEK 1037
Query: 297 KEIQSLKSQISAL--QKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQK 354
+ + + +I L Q S + C+T++ N ++ + E L+ + + + +Q+
Sbjct: 1038 ERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLA---RIETLQSNAKLLEVQILEVQR 1094
Query: 355 DILAKDEQVQQLKEEVSHLKSQNKDKDH-----QLEALGSRCSVLKEELKQEDAHRELRE 409
D+++ E L+ + K K+H +LE L + K++L++ EL +
Sbjct: 1095 AKAMVDKEL-----EAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVK 1149
Query: 410 AQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQED--SRRK 467
++ L +I D E+ MK+L +L + + + ++ + + +E LQE+ S +
Sbjct: 1150 KDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQS 1209
Query: 468 LLQLQEMGN---RESVIKINLERA----------------VGQLEHFRSQVIKATYGRAK 508
+Q E N ++ ++K E A G+LE + QV A+
Sbjct: 1210 SVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAE 1269
Query: 509 PFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDS 568
+K + L Q +QQ+ LQ+E + + ++Q T E + + +
Sbjct: 1270 ITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHN 1329
Query: 569 CQACMKISCCS----HDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLR 624
K S K+E + L+ L + L+ + D + + E++ L
Sbjct: 1330 VLKQQKNKSMSQAETEGAKQEREHLEML-----IDQLKIKLQDSQNNLQINVSELQTLQS 1384
Query: 625 DLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGR 684
+ L NK + S + + K + + + SQN+ R
Sbjct: 1385 EHDTLLERHNKMLQETVSKEAEL--REKLCSIQSENMMMKSEHTQTVSQLTSQNEVL--R 1440
Query: 685 EGGKALEEYITQERNRAKETLEEERKRM--------------------QELESLLAQQKK 724
+ ++ +E + ETL+++ +M Q L++L ++
Sbjct: 1441 NSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNT 1500
Query: 725 AL----AKSITQEKNRVKEALEEE-----QTRVQELEERLARQKEVLESSIAHEKRKAKE 775
L ++T+E+ E + E T Q LE+ L + LE + H + +E
Sbjct: 1501 DLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEE 1560
Query: 776 ALE--SEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEE 833
++ S K D N L ++ E + + + E ++ K +++ LE ++K
Sbjct: 1561 LVQKLSSTTKSADHLNGLLRETEATNAIL-------MEQIKLLKSEIRRLERNQEREKSA 1613
Query: 834 LELKEQKEDVL 844
L+ K +L
Sbjct: 1614 ANLEYLKNVLL 1624
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 129 bits (324), Expect = 2e-29
Identities = 222/1031 (21%), Positives = 445/1031 (43%), Gaps = 155/1031 (15%)
Query: 223 QQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEIS 282
++D D++ L L K E E + + NL E+A L + +++ T ++ +E
Sbjct: 951 KRDIDDLELTLAK-------VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1003
Query: 283 QKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDN 342
Q Q LD+ +Q+ + +++ L K K L Q + + + K +L+R
Sbjct: 1004 Q--QALDD--------LQAEEDKVNTLTKAKVK-LEQQVDDLEGSLEQEKKVRMDLERAK 1052
Query: 343 AITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQED 402
G + Q+ I+ + QQL E + K KD +L AL +R ++ E
Sbjct: 1053 RKLEGDLKLTQESIMDLENDKQQLDERL-------KKKDFELNALNAR-------IEDEQ 1098
Query: 403 AHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQE 462
A L +K+LK + +I+++E+E++ R K +S +SR L E + E+L+E
Sbjct: 1099 A---LGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEE---ISERLEE 1152
Query: 463 DSRRKLLQLQEMGNRESVI-KINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLI 521
+Q++ RE+ K+ + L+H +AT A R K
Sbjct: 1153 AGGATSVQIEMNKKREAEFQKMRRDLEEATLQH------EAT---AAALRKKHA------ 1197
Query: 522 EKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIE---KLRTSLDSCQACMKISCC 578
+ + ++ E N Q+ K L+KE + ++ T N+E K + +L+ ++
Sbjct: 1198 DSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMN 1257
Query: 579 SHDLKKEV------DL--------LQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLR 624
H K E DL ++ ++S + + ++ + R L++ +++E L R
Sbjct: 1258 EHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKR 1317
Query: 625 DLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGR 684
L +++V+ + + + + RE E EA+A + ++
Sbjct: 1318 QL--------EEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1369
Query: 685 EGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEE 744
+ E Q +E ++ +R+QE E + + A S+ + K+R++ +E+
Sbjct: 1370 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAV-EAVNAKCSSLEKTKHRLQNEIEDL 1428
Query: 745 QTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAY 804
V+ + +++ ++R + L K+K ++ ++ L ++ + S ++
Sbjct: 1429 MVDVE--------RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARS-LST 1479
Query: 805 EKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKAT 864
E K K A E + LE+ T ++E L+E+ D L +L + + E +K +
Sbjct: 1480 ELFKLKNAYE------ESLEHLETFKRENKNLQEEISD-LTEQLGSSGKTIHELEKVR-- 1530
Query: 865 ESLKAESLALK--LNETLAELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEI 922
+ L+AE + L+ L E A LE + K++ R L+ +KA + + +++ +EE+
Sbjct: 1531 KQLEAEKMELQSALEEAEASLEHEEGKIL----RAQLEFNQIKAEIERKLAEK---DEEM 1583
Query: 923 MEYKEQIKQHAQTIVSLEEKLQKVTQHH-------KKIEGEIATLKDNDPAPKEERPQDP 975
+ K + H + + SL+ L T+ KK+EG++ ++ +
Sbjct: 1584 EQAK---RNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQ 1640
Query: 976 LVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRG----- 1030
+S KD + +DD + A + L + I++ R +L +A + +LR
Sbjct: 1641 KQVKSLQSLLKDTQIQ--LDDAVRANDD-LKENIAIVERRNNLLQA--ELEELRAVVEQT 1695
Query: 1031 ----ELNEKQKMELEQNVVLVQQQSKELSVLKEKM----AQMSSLVEKKDRELK-ALEEA 1081
+L E++ +E + V L+ Q+ L K+KM +Q+ + VE+ +E + A E+A
Sbjct: 1696 ERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKA 1755
Query: 1082 LRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGS 1141
+A + + +KEQ DTS +E + +Q+ DL R
Sbjct: 1756 KKAITDAAMMAEELKKEQ---------DTSAHLERM------KKNMEQTIKDLQHRL-DE 1799
Query: 1142 RHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAKP 1201
+ ++ KK L +L AR++ELE + K ES ++ + E ++++ +
Sbjct: 1800 AEQIALKGGKKQLQKLEARVRELENELEAEQK-RNAESVKGMR--KSERRIKELTYQTEE 1856
Query: 1202 DLPTLSRIEIL 1212
D L R++ L
Sbjct: 1857 DRKNLLRLQDL 1867
Score = 116 bits (290), Expect = 2e-25
Identities = 232/1125 (20%), Positives = 459/1125 (40%), Gaps = 158/1125 (14%)
Query: 322 SERNSEITSLKNEGENLK--------RDNAITSGMVSSLQK-------------DILAKD 360
+ER E+ S+K E LK R + MVS LQ+ ++ +
Sbjct: 843 AEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAE 902
Query: 361 EQVQQLKEEVSHLKSQNKDKDHQL---EALGSRCSVLKEELKQEDAHRELREAQEKELKL 417
E+ QL + L+++ K+ + +L E + + + K +L+ E + + R+ + EL L
Sbjct: 903 ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK-RDIDDLELTL 961
Query: 418 CKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNR 477
K +EKE +++ E + + + + +K ++ LQE ++ L LQ ++
Sbjct: 962 AK-----VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDK 1016
Query: 478 ESVI---KINLERAVGQLEHFRSQVIKATYGRAKPFR------------------DKPVT 516
+ + K+ LE+ V LE Q K + R DK
Sbjct: 1017 VNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQL 1076
Query: 517 DQQLIEKITQVTEDNINFQQKK---WTLQKETQLSNSKQEETTENIEKLRTSLDSCQACM 573
D++L +K ++ N + ++ LQK+ + ++ EE E +E RT A
Sbjct: 1077 DERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERT------ARA 1130
Query: 574 KISCCSHDLKKEV-DLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDL--GILP 630
K+ DL +E+ ++ + L+ + + +Q + ++ R A E +++ RDL L
Sbjct: 1131 KVEKLRSDLSRELEEISERLEEAGGATSVQ-IEMNKKREA-----EFQKMRRDLEEATLQ 1184
Query: 631 SSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKA- 689
+++ +S + + + E+ ++ + E + KA
Sbjct: 1185 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN 1244
Query: 690 -------LEEYITQERNRAKET------LEEERKRMQELESLLAQQ---KKALAKSITQE 733
LE+ + + R++A+ET L +R ++Q L++Q K+AL +T+
Sbjct: 1245 LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRG 1304
Query: 734 KNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQ 793
K + LE+ + +++E + L+S+ H+ +E E E +L+ L++
Sbjct: 1305 KLTYTQQLEDLKRQLEEEVKAKNALAHALQSA-RHDCDLLREQYEEETEAKAELQRVLSK 1363
Query: 794 -QKEISESNIAYE------KRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNN 846
E+++ YE + +EA +K +++Q+ E + + E+ + L N
Sbjct: 1364 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQN 1423
Query: 847 KLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKM-IMVEERLILQQKMVK 905
++ D + VE + A K + L E + E +++++ +E L ++ K
Sbjct: 1424 EIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFK 1483
Query: 906 ALQDEQESQRH---------GFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGE 956
+ES H +EEI + EQ+ +TI +L+KV + + + E
Sbjct: 1484 LKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI----HELEKVRKQLEAEKME 1539
Query: 957 IATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRK 1016
+ + + A E L A + + K L + ++ + V+ L+
Sbjct: 1540 LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQT 1599
Query: 1017 DL-TEAHSRMSDLR------GELNEK--QKMELEQNVVLVQQQSKEL-SVLKEKMAQMSS 1066
L E SR LR G+LNE Q + Q+Q K L S+LK+ Q+
Sbjct: 1600 SLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD 1659
Query: 1067 LVEKKD--RELKALEE----ALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTE 1120
V D +E A+ E L+A E+ R + + + + + +TS +++ +H++
Sbjct: 1660 AVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQ 1719
Query: 1121 AFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESF 1180
+S Q+ D + + EE +Q + A + + I + K+ +
Sbjct: 1720 N-TSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1778
Query: 1181 LDLKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDV----A 1236
L+ RM+ N+++ + D + L +I + K GK + A
Sbjct: 1779 LE----RMKKNMEQTIKDLQHRLDEAEQIAL-----------------KGGKKQLQKLEA 1817
Query: 1237 EALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQ-EREKVNQLRQRDL-DLVFDKI 1294
EL +L + + S+ ++ + K L+ Q E ++ N LR +DL D + K+
Sbjct: 1818 RVRELENELEAEQKRNAESVKGMRKSERRI--KELTYQTEEDRKNLLRLQDLVDKLQLKV 1875
Query: 1295 TQLKNQLGRKEEL----LRGYEKDVEQLRRSKVSIEMYQSQVAKL 1335
K Q EE L + K +L ++ ++ +SQV KL
Sbjct: 1876 KAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1920
Score = 114 bits (284), Expect = 9e-25
Identities = 166/798 (20%), Positives = 329/798 (41%), Gaps = 117/798 (14%)
Query: 654 AGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQ 713
A A R + + + + + + N+ + E + +T ++ + ++ E ++ +
Sbjct: 899 ADAEERCDQLIKNKIQLEAKVKEMNERLEDEE---EMNAELTAKKRKLEDECSELKRDID 955
Query: 714 ELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHEKR-- 771
+LE LA+ +K K T+ N+VK L EE + E+ +L ++K+ L+ AH++
Sbjct: 956 DLELTLAKVEKE--KHATE--NKVKN-LTEEMAGLDEIIAKLTKEKKALQE--AHQQALD 1008
Query: 772 -------------KAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKK 818
KAK LE + V DLE L Q+K++ ++ KRK + ++ ++
Sbjct: 1009 DLQAEEDKVNTLTKAKVKLEQQ---VDDLEGSLEQEKKV-RMDLERAKRKLEGDLKLTQE 1064
Query: 819 KVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNE 878
+ DLEN + E L+ K+ + + LN ++ D A+ + QK K + L ++ E
Sbjct: 1065 SIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQK-------KLKELQARIEE 1117
Query: 879 TLAELETTKTKMIMVE--------------ERL-------ILQQKMVKALQDEQESQRHG 917
ELE +T VE ERL +Q +M K + E + R
Sbjct: 1118 LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD 1177
Query: 918 FEEEIMEYKEQI----KQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQ 973
EE ++++ K+HA ++ L E++ + + +K+E E + K
Sbjct: 1178 LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK---------LEL 1228
Query: 974 DPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELN 1033
D + + M + E + L E S+ E + DLT +++ GEL+
Sbjct: 1229 DDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELS 1288
Query: 1034 EKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQL 1093
+L++ L+ Q ++ +++ + +E++ + AL AL++++
Sbjct: 1289 R----QLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR------- 1337
Query: 1094 NTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHE-EVIQRQKK 1152
CD + TEA + Q S ++ V +++E + IQR ++
Sbjct: 1338 ------------HDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEE 1385
Query: 1153 ALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLSRIEIL 1212
+ + L++A + S L+ R++N ++ +++D + + ++
Sbjct: 1386 LEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK 1445
Query: 1213 APQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLS 1272
A + E+S LE S+K +S L L N + S+++L
Sbjct: 1446 QRNFDKILAEWKQKYEES-----QSELESSQKEARSLSTELFKLKN----AYEESLEHLE 1496
Query: 1273 RQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQV 1332
+RE N + ++I+ L QLG + + EK +QL K+ + Q
Sbjct: 1497 TFKRENKN---------LQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMEL-----QS 1542
Query: 1333 AKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLR 1392
A E + E EE +L+ LE + + E+++ + + R +D + L
Sbjct: 1543 ALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLD 1602
Query: 1393 KETSSKSSQSLLHSKPSG 1410
ET S++ + K G
Sbjct: 1603 AETRSRNEALRVKKKMEG 1620
Score = 92.4 bits (228), Expect = 3e-18
Identities = 149/725 (20%), Positives = 316/725 (43%), Gaps = 71/725 (9%)
Query: 720 AQQKKALAKSITQEKNRVKEALEEEQTRVQELEER---LARQKEVLESSIAHEKRKAKEA 776
A+++K +A S+ +E R+KEALE+ + R +ELEE+ L ++K L+ + E+ +A
Sbjct: 843 AEREKEMA-SMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADA 901
Query: 777 LE----------SEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENR 826
E + KV+++ L ++E++ + + +KRK ++ + K+ + DLE
Sbjct: 902 EERCDQLIKNKIQLEAKVKEMNERLEDEEEMN-AELTAKKRKLEDECSELKRDIDDLELT 960
Query: 827 LTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETT 886
L K ++E E K L +++ ++ + K K ++L + L +L+
Sbjct: 961 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEK-------KALQEAHQQALDDLQAE 1013
Query: 887 KTKMIMVEERLILQQKMVKALQ---DEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKL 943
+ K+ + + + ++ V L+ ++++ R E + + +K ++I+ LE
Sbjct: 1014 EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1073
Query: 944 QKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKE 1003
Q++ + KK + E+ L N E+ L + E A+ E L ++L A +
Sbjct: 1074 QQLDERLKKKDFELNAL--NARIEDEQALGSQLQKKLKELQAR---IEELEEELEAERTA 1128
Query: 1004 ILSQQEVIMKLRKDLTEAHSRMSDLRG------ELNEK-----QKMELEQNVVLVQQQSK 1052
+++ L ++L E R+ + G E+N+K QKM + +Q ++
Sbjct: 1129 RAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEAT 1188
Query: 1053 ELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQLN---TEKEQKPRKKTQTCD 1109
++ K+ ++ L E+ D L+ +++ L + + +L+L+ + EQ + K
Sbjct: 1189 AAALRKKHADSVAELGEQID-NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEK 1247
Query: 1110 TSVQIEPVHTEAFSSSQE-QQSFSDL-GVRCKGSRHEEVIQRQKKALSELRARIKELEKA 1167
+E E S ++E Q+S +DL R K + RQ L E A I +L +
Sbjct: 1248 MCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ---LDEKEALISQLTRG 1304
Query: 1168 RSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTL-----SRIEILAPQNGLCNAR 1222
+ + ++ + ++ +N + L A+ D L E A + +
Sbjct: 1305 KLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKA 1364
Query: 1223 FGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQL 1282
+ K + +A++ +E+L K L + V+ K S ++ + Q
Sbjct: 1365 NSEVAQWRTKYE-TDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQN 1423
Query: 1283 RQRDLDLVFDKITQLKNQLGRKEELLRGYEKDV----EQLRRSKVSIEMYQSQVAKLEDD 1338
DL + ++ L +K+ R ++K + ++ S+ +E Q + L +
Sbjct: 1424 EIEDLMVDVERSNAAAAALDKKQ---RNFDKILAEWKQKYEESQSELESSQKEARSLSTE 1480
Query: 1339 IYKEAEEKALLKEALERMEHQLCQEKRINRAIRQ--QKVGTRKASLKMDQEREMLRKETS 1396
++K K +E+LE +E + K + I +++G +S K E E +RK+
Sbjct: 1481 LFK---LKNAYEESLEHLETFKRENKNLQEEISDLTEQLG---SSGKTIHELEKVRKQLE 1534
Query: 1397 SKSSQ 1401
++ +
Sbjct: 1535 AEKME 1539
Score = 80.5 bits (197), Expect = 1e-14
Identities = 146/787 (18%), Positives = 331/787 (42%), Gaps = 90/787 (11%)
Query: 236 EVSRLSDYEIESKYKDVIIANLQNE-------------VAELSQKVSETTTSRQN-EKEI 281
E+++ + E + +D+ A LQ+E VAEL +++ +Q EKE
Sbjct: 1162 EMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEK 1221
Query: 282 SQKCQVLDEDIDAKQKEIQSLKSQISAL----------QKGYSKVLCQTLSERNSEITSL 331
S+ LD D+ + ++I K+ + + + ++ +++++ S+ L
Sbjct: 1222 SEFKLELD-DVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKL 1280
Query: 332 KNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRC 391
+ E L R ++S L + L +Q++ LK ++ H L++ C
Sbjct: 1281 QTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDC 1340
Query: 392 SVLKEELKQE-DAHRELREAQEK---ELKLCKT--------QIQDMEKEMKKLRAELRKS 439
+L+E+ ++E +A EL+ K E+ +T + +++E+ KKL L+++
Sbjct: 1341 DLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA 1400
Query: 440 CTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVI--------------KINL 485
++ K + +LQ + ++ ++ + + K
Sbjct: 1401 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKY 1460
Query: 486 ERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKET 545
E + +LE + + + + F+ K ++ L E + +N N Q++ L +
Sbjct: 1461 EESQSELESSQKEARSLS---TELFKLKNAYEESL-EHLETFKRENKNLQEEISDLTE-- 1514
Query: 546 QLSNSKQEETTENIEKLRTSLDS----CQACMKISCCSHDLKKEVDLLQHLQVSPPVSGL 601
QL +S +T +EK+R L++ Q+ ++ + S + ++ L L+
Sbjct: 1515 QLGSS--GKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE-------F 1565
Query: 602 QKVVLDVLRHALSWLEEVEQLLRD-LGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGRE 660
++ ++ R EE+EQ R+ L ++ S + S N A+ K G E
Sbjct: 1566 NQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEG-DLNE 1624
Query: 661 GEAERGEA-RARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLL 719
E + A R EAQ Q ++ ++ + RA + L+E ++ +LL
Sbjct: 1625 MEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ---LDDAVRANDDLKENIAIVERRNNLL 1681
Query: 720 ---AQQKKALAKSITQEKNRVKEALEEEQTRVQELEER---LARQKEVLESSIAHEKRKA 773
++ +A+ + + + ++ L E RVQ L + L QK+ +++ ++ + +
Sbjct: 1682 QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEV 1741
Query: 774 KEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAK-EAMEKE-KKKVQDLENRLTKQK 831
+EA++ + + + +T ++E + A E M+K ++ ++DL++RL +
Sbjct: 1742 EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRL-DEA 1800
Query: 832 EELELKEQKEDV--LNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTK 889
E++ LK K+ + L ++ + +E QK A ++ E + E +
Sbjct: 1801 EQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKN 1860
Query: 890 MIMVE---ERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKV 946
++ ++ ++L L+ K K +E E Q + + + + ++ + + E ++ K+
Sbjct: 1861 LLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1920
Query: 947 TQHHKKI 953
+ I
Sbjct: 1921 RAKSRDI 1927
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 129 bits (324), Expect = 2e-29
Identities = 235/1057 (22%), Positives = 454/1057 (42%), Gaps = 139/1057 (13%)
Query: 224 QDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQ 283
Q+K+++ L + E L+D E D +I N +L KV E ++E+E
Sbjct: 884 QEKNDLQLQVQAEQDNLNDAEERC---DQLIKNK----IQLEAKVKEMNERLEDEEE--- 933
Query: 284 KCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNA 343
++ ++ AK+++ L+ + S L+K L TL++ E + +N+ +NL + A
Sbjct: 934 ----MNAELTAKKRK---LEDECSELKKDIDD-LELTLAKVEKEKHATENKVKNLTEEMA 985
Query: 344 ITSGMVSSLQKDILAKDEQVQQ----LKEEVSHLKSQNKDK---DHQLEAL-GSRCSVLK 395
+++ L K+ A E QQ L+ E + S +K K + Q++ L GS K
Sbjct: 986 GLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKK 1045
Query: 396 EELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRK----------SCTEQSV 445
+ E A R+L E +LKL + I D+E + +L +L+K ++ V
Sbjct: 1046 VRMDLERAKRKL----EGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQV 1101
Query: 446 ISRTLREKSKVE---------------------EKLQEDSRRKLLQ----LQEMGNRESV 480
++ L++K K EKL+ D R+L + L+E G SV
Sbjct: 1102 LALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSV 1161
Query: 481 -IKINLERAVGQLEHFRSQVIKATY---GRAKPFRDKPVTDQQLIEKITQVTEDNINFQQ 536
I++N +R + + R + +AT A R K + + ++ E N Q+
Sbjct: 1162 QIEMNKKRE-AEFQKMRRDLEEATLQHEATAAALRKKHA------DSVAELGEQIDNLQR 1214
Query: 537 KKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDL-LQHLQVS 595
K L+KE + ++ T N+E++ + + + K+S D E + L+ Q S
Sbjct: 1215 VKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLE---KVSRTLEDQANEYRVKLEEAQRS 1271
Query: 596 PPVSGLQKVVLDVLRHALS-WLEEVEQLLRDL--GILPSSPNKDQVQQFSGNSAVFTAGK 652
Q+ L L+ LEE E L+ L G L + + +++ + GK
Sbjct: 1272 LNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKR-----QLEEEGK 1326
Query: 653 AAGASGREGEAERGEA---RARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEER 709
A A ++ R + R + E +++ +A R KA E + Q R + + +
Sbjct: 1327 AKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE-VAQWRTKYETDAIQRT 1385
Query: 710 KRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESSIAHE 769
+ ++E + LAQ+ Q+ EA+ + + +++ + RL + E L +
Sbjct: 1386 EELEEAKKKLAQR--------LQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV-ER 1436
Query: 770 KRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAK----EAMEKEKKKVQDLEN 825
A AL+ ++R + Q+ E S+S + +++A+ E + + + LE+
Sbjct: 1437 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1496
Query: 826 RLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELET 885
T ++E L+E+ D L +L + V E +K + ++ L L E A LE
Sbjct: 1497 LETFKRENKNLQEEISD-LTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEH 1555
Query: 886 TKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQ- 944
+ K++ R L+ +KA + + +++ E+ +++ QT + E + +
Sbjct: 1556 EEGKIL----RAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRN 1611
Query: 945 KVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEI 1004
+V + KK+EG++ ++ + +S KD + +DD + A +
Sbjct: 1612 EVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ--LDDAVRANDD- 1668
Query: 1005 LSQQEVIMKLRKDLTEAHSRMSDLRG---------ELNEKQKMELEQNVVLVQQQSKELS 1055
L + I++ R +L +A + +LR +L E++ +E + V L+ Q+ L
Sbjct: 1669 LKENIAIVERRNNLLQA--ELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1726
Query: 1056 VLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIE 1115
K+KM S L + + +A++E A ++ + + + KK Q DTS +E
Sbjct: 1727 NQKKKME--SDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ--DTSAHLE 1782
Query: 1116 PVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDH 1175
+ +Q+ DL R + ++ KK L +L AR++ELE + K
Sbjct: 1783 RM------KKNMEQTIKDLQHRL-DEAEQIALKGGKKQLQKLEARVRELEGELEAEQK-R 1834
Query: 1176 QNESFLDLKNLRMENNVQKILLDAKPDLPTLSRIEIL 1212
ES ++ + E ++++ + D L R++ L
Sbjct: 1835 NAESVKGMR--KSERRIKELTYQTEEDKKNLLRLQDL 1869
Score = 108 bits (269), Expect = 5e-23
Identities = 166/758 (21%), Positives = 317/758 (41%), Gaps = 104/758 (13%)
Query: 691 EEYITQERNRAKETLEEE----RKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQT 746
EE + E K LE+E +K + +LE LA+ +K K T+ N+VK L EE
Sbjct: 931 EEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE--KHATE--NKVKN-LTEEMA 985
Query: 747 RVQELEERLARQKEVLESSIAHEKRKAKEALESEK------------RKVQDLENHLTQQ 794
+ E+ +L ++K+ L+ AH++ +E +K ++V DLE L Q+
Sbjct: 986 GLDEIIAKLTKEKKALQE--AHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQE 1043
Query: 795 KEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAM 854
K++ ++ KRK + ++ ++ + DLEN + +E+L+ KE + N+K+ D +
Sbjct: 1044 KKV-RMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVL 1102
Query: 855 VEETQK---------TKATESLKAESLAL----KLNETLA-ELETTKTKMIMVEERLILQ 900
+ QK + E L+AE A KL L+ ELE ++ +Q
Sbjct: 1103 ALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQ 1162
Query: 901 QKMVKALQDEQESQRHGFEEEIMEYKEQI----KQHAQTIVSLEEK---LQKVTQHHKKI 953
+M K + E + R EE ++++ K+HA ++ L E+ LQ+V Q +K
Sbjct: 1163 IEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1222
Query: 954 EGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMK 1013
+ E D+ + E+ + + +D A E+ + L AQ+ +
Sbjct: 1223 KSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRV-KLEEAQRSL--------- 1272
Query: 1014 LRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDR 1073
D T +++ GEL +LE+ L+ Q ++ ++M + +E++ +
Sbjct: 1273 --NDFTTQRAKLQTENGEL----ARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGK 1326
Query: 1074 ELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSD 1133
AL AL++++ CD + TEA + Q S ++
Sbjct: 1327 AKNALAHALQSAR-------------------HDCDLLREQYEEETEAKAELQRVLSKAN 1367
Query: 1134 LGVRCKGSRHE-EVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNV 1192
V +++E + IQR ++ + + L+ A + S L+ R++N +
Sbjct: 1368 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEI 1427
Query: 1193 QKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKT 1252
+ +++D + + ++ A + E+S LE S+K +S
Sbjct: 1428 EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES-----QSELESSQKEARSLSTE 1482
Query: 1253 LGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYE 1312
L L N + S+++L +RE N + ++I+ L QLG + + E
Sbjct: 1483 LFKLKN----AYEESLEHLETFKRENKN---------LQEEISDLTEQLGEGGKNVHELE 1529
Query: 1313 KDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQ 1372
K R ++ +E + Q A E + E EE +L+ LE + + E+++ +
Sbjct: 1530 K-----VRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEE 1584
Query: 1373 QKVGTRKASLKMDQEREMLRKETSSKSSQSLLHSKPSG 1410
+ R +D + L ET S++ + K G
Sbjct: 1585 MEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEG 1622
Score = 104 bits (260), Expect = 5e-22
Identities = 213/1161 (18%), Positives = 468/1161 (40%), Gaps = 149/1161 (12%)
Query: 322 SERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKD 381
+E E+ ++K E +K T + +K++ +E++ L +E + L+ Q + +
Sbjct: 845 AETEKEMATMKEEFGRIKE----TLEKSEARRKEL---EEKMVSLLQEKNDLQLQVQAEQ 897
Query: 382 HQLEALGSRCS-VLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSC 440
L RC ++K +++ E +E+ E E E ++M E+ + +L C
Sbjct: 898 DNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDE--------EEMNAELTAKKRKLEDEC 949
Query: 441 TE--------QSVISRTLREKSKVEEK------------------------LQEDSRRKL 468
+E + +++ +EK E K LQE ++ L
Sbjct: 950 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQAL 1009
Query: 469 LQLQ---EMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKIT 525
LQ + N S K+ LE+ V LE Q K + R + E I
Sbjct: 1010 DDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIM 1069
Query: 526 QVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKE 585
+ D + ++K + + NSK E+ +L+ L QA ++ +L++E
Sbjct: 1070 DLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIE------ELEEE 1123
Query: 586 VDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNS 645
++ + + ++K+ D+ R LEE+ + L + G Q++
Sbjct: 1124 LEAERTARAK-----VEKLRSDLSRE----LEEISERLEEAG----GATSVQIEMNKKRE 1170
Query: 646 AVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETL 705
A F + A + A S + + + + +++ + +E++ K L
Sbjct: 1171 AEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEL 1230
Query: 706 EEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQ----------TRVQELEERL 755
++ M+++ A +K +++++ + N + LEE Q ++Q L
Sbjct: 1231 DDVTSNMEQIIKAKANLEK-VSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGEL 1289
Query: 756 ARQ---KEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEA 812
ARQ KE L S + K + +E KR++++ E + + ++ +E
Sbjct: 1290 ARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEE-EGKAKNALAHALQSARHDCDLLREQ 1348
Query: 813 MEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTK---ATESLKA 869
E+E + +L+ L+K E+ K + +DA+ EE ++ K A A
Sbjct: 1349 YEEETEAKAELQRVLSKANSEVAQWRTKYE------TDAIQRTEELEEAKKKLAQRLQDA 1402
Query: 870 ESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQI 929
E +N + LE TK ++ E L++ + A + ++ F++ + E+K++
Sbjct: 1403 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKY 1462
Query: 930 KQHAQTIVSLEEKLQKVTQHHKKIEGEI-ATLKDNDPAPKEERPQDPLVAPMTESSAKDM 988
++ + S +++ + ++ K++ +L+ + +E + ++ +TE +
Sbjct: 1463 EESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGG 1522
Query: 989 AYEHLIDDLLAAQKEILSQQEV-IMKLRKDLTEAHSRMSDLRGELNEKQ------KMELE 1041
H ++ ++ Q EV ++L+ L EA + + G++ Q K E+E
Sbjct: 1523 KNVHELE-------KVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE 1575
Query: 1042 QNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQKP 1101
+ L ++ + + + SL D E ++ E LR ++K LN + Q
Sbjct: 1576 RK--LAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRV-KKKMEGDLNEMEIQLS 1632
Query: 1102 RKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEE--VIQRQ----KKALS 1155
+ Q++ + S ++ Q D VR E +++R+ + L
Sbjct: 1633 HANRMAAEAQKQVKSLQ----SLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELE 1688
Query: 1156 ELRARIKELEKARSPDHKD------------HQNESFLDLKNLRMENNVQKILLDAKPDL 1203
ELRA +++ E++R ++ QN S ++ K +ME+++ ++ + + +
Sbjct: 1689 ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK-KMESDLTQLQSEVEEAV 1747
Query: 1204 PTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMS 1263
E A + A ++K + D + LE +K +M +T+ L + + +
Sbjct: 1748 QECRNAEEKAKKAITDAAMMAEELKK--EQDTSAHLERMKK---NMEQTIKDLQHRLDEA 1802
Query: 1264 GHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKV 1323
+++K +Q ++ + R R+L+ +L+ + R E ++G K +++
Sbjct: 1803 EQIALKGGKKQLQKL--EARVRELE------GELEAEQKRNAESVKGMRKSERRIKELTY 1854
Query: 1324 SIEMYQSQVAKLEDDIYK-EAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASL 1382
E + + +L+D + K + + KA ++A E E + + + +A +
Sbjct: 1855 QTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADI 1914
Query: 1383 KMDQEREMLRKETSSKSSQSL 1403
Q ++ K + Q +
Sbjct: 1915 AESQVNKLRAKSRDIGAKQKM 1935
Score = 78.6 bits (192), Expect = 4e-14
Identities = 140/778 (17%), Positives = 317/778 (40%), Gaps = 72/778 (9%)
Query: 236 EVSRLSDYEIESKYKDVIIANLQNE-------------VAELSQKVSETTTSRQN-EKEI 281
E+++ + E + +D+ A LQ+E VAEL +++ +Q EKE
Sbjct: 1164 EMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEK 1223
Query: 282 SQKCQVLDEDIDAKQKEIQSLKSQISALQKGYS----------KVLCQTLSERNSEITSL 331
S+ LD D+ + ++I K+ + + + + ++L++ ++ L
Sbjct: 1224 SEFKLELD-DVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKL 1282
Query: 332 KNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRC 391
+ E L R ++S L + L+ +Q++ LK ++ H L++ C
Sbjct: 1283 QTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDC 1342
Query: 392 SVLKEELKQE-DAHRELREAQEK---ELKLCKT--------QIQDMEKEMKKLRAELRKS 439
+L+E+ ++E +A EL+ K E+ +T + +++E+ KKL L+ +
Sbjct: 1343 DLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDA 1402
Query: 440 CTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVI---KINLERAVGQLEHFR 496
++ K + +LQ + ++ ++ + + + N ++ + + +
Sbjct: 1403 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKY 1462
Query: 497 SQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETT 556
+ K R +L + E F+++ LQ+E + E
Sbjct: 1463 EESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGG 1522
Query: 557 ENI---EKLRTSLD----SCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVL 609
+N+ EK+R L+ Q+ ++ + S + ++ L L+ ++ ++
Sbjct: 1523 KNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLE-------FNQIKAEIE 1575
Query: 610 RHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEA- 668
R EE+EQ R+ + S + + V K E E + A
Sbjct: 1576 RKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHAN 1635
Query: 669 RARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLL---AQQKKA 725
R EAQ Q ++ ++ + RA + L+E ++ +LL ++ +A
Sbjct: 1636 RMAAEAQKQVKSLQSLLKDTQIQ---LDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1692
Query: 726 LAKSITQEKNRVKEALEEEQTRVQELEER---LARQKEVLESSIAHEKRKAKEALESEKR 782
+ + + + ++ L E RVQ L + L QK+ +ES + + + +EA++ +
Sbjct: 1693 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRN 1752
Query: 783 KVQDLENHLTQQKEISESNIAYEKRKAK-EAMEKE-KKKVQDLENRLTKQKEELELKEQK 840
+ + +T ++E + A E M+K ++ ++DL++RL + E++ LK K
Sbjct: 1753 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRL-DEAEQIALKGGK 1811
Query: 841 EDV--LNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVE---E 895
+ + L ++ + +E QK A ++ E + E K ++ ++ +
Sbjct: 1812 KQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVD 1871
Query: 896 RLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKI 953
+L L+ K K +E E Q + + + + ++ + + E ++ K+ + I
Sbjct: 1872 KLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1929
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 126 bits (317), Expect = 1e-28
Identities = 211/1057 (19%), Positives = 451/1057 (42%), Gaps = 123/1057 (11%)
Query: 214 EIYVEEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTT 273
E+ ++ Q+K+++IL L E L++ E + ++ L+ V ELS++V E
Sbjct: 884 ELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEE--- 940
Query: 274 SRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQI--SALQKGYSKVLCQTLSER----NSE 327
+ E++ + + L+++ +KEI L++ + S +K ++ + L+E N +
Sbjct: 941 EEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNED 1000
Query: 328 ITSLKNEGENLKR-------DNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDK 380
I+ L + ++ D + +SSL K L ++QV +L+ + + +
Sbjct: 1001 ISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNC 1060
Query: 381 DHQLEALGSRCSVLKEELKQ-EDAHREL-REAQEKELKLCKTQIQDMEKEMKKLRAELRK 438
+ +L L + +E ++ E + R L E ++KEL+L +Q+ + K L A+L+K
Sbjct: 1061 ERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELEL--SQMNSKVENEKGLVAQLQK 1118
Query: 439 SCTEQSVISRTLREKSKVEEKLQEDSRRKLLQL-QEMGNRESVIKINLERAVGQLEHFRS 497
+ E + L+EK + E + R+ L Q++ + ++ ++ QLE +
Sbjct: 1119 TVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKK 1178
Query: 498 QVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTE 557
Q K K RD + E ++F+ +L+K S ++ E E
Sbjct: 1179 QETKF----QKLHRD--------------MEEATLHFETTSASLKKRHADSLAELEGQVE 1220
Query: 558 NIEKLRTSLDSCQACMKISCCSHDLKKEVDLL-----QHLQVSPPVSGLQKVVLDVLRHA 612
N+++++ L+ ++ DL+ EVD L Q + L + + L A
Sbjct: 1221 NLQQVKQKLEKDKS---------DLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEA 1271
Query: 613 LSWLEEVEQLLRDLGILPS---SPNKDQVQQFSGNSAVFT-AGKAAGASGREGEAERGEA 668
+ L++V QL DL + S + + +++ A+ + R+ E RG+
Sbjct: 1272 TAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQL 1331
Query: 669 RARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAK 728
E +SQ+ + + + + ++ +E E + + ++ + + Q +
Sbjct: 1332 EK--ETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYEN 1389
Query: 729 SITQEKNRVKEALEEEQTRVQELEERL--ARQKEVLESSIAHEKRKAKEALESEKRKVQD 786
++ Q +++A +E R+QE E + A + H+ + S+ KV+
Sbjct: 1390 NVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRS 1449
Query: 787 LENHLTQQKEISESNIAYEKRKAKEA---MEKEKKKVQDLENRLTKQKEELE-------- 835
L Q++ S +A K+K +E+ ++ +K+VQ L L K K E
Sbjct: 1450 AAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQET 1509
Query: 836 LKEQKEDV------LNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTK 889
L+ + +++ L N++ + + E +K K + + + L ET LE ++K
Sbjct: 1510 LRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESK 1569
Query: 890 MIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQ----- 944
++ + L+ KA + + S++ +EEI ++ ++ TI SL+ L
Sbjct: 1570 ILHFQLELL----EAKAELERKLSEK---DEEIENFR---RKQQCTIDSLQSSLDSEAKS 1619
Query: 945 --KVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQK 1002
+VT+ KK+E ++ ++ + + + KD+ + +DD
Sbjct: 1620 RIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQ--LDDSTQLNS 1677
Query: 1003 EILSQQEVIMKLRKDLTEAHSRMSDLRG---------ELNEKQKMELEQNVVLVQQQSKE 1053
+ L +Q + + R L + S + DLR L+E++ +E + + L Q+
Sbjct: 1678 D-LKEQVAVAERRNSLLQ--SELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTS 1734
Query: 1054 LSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQ 1113
L K+K+ + ++K+ E+ ++E A ++ + + + KK Q DT
Sbjct: 1735 LLSQKKKLEADVARMQKEAEEV--VQECQNAEEKAKKAAIEAANLSEELKKKQ--DTIAH 1790
Query: 1114 IEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHK 1173
+E + +Q+ +DL R + + +K + +L +R++ELE + +
Sbjct: 1791 LER------TRENMEQTITDLQKRL-AEAEQMALMGSRKQIQKLESRVRELEGELEGEIR 1843
Query: 1174 DHQNESFLDLKNLRMENNVQKILLDAKPDLPTLSRIE 1210
+ R+E ++++ A+ D LSR++
Sbjct: 1844 ---RSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQ 1877
Score = 90.9 bits (224), Expect = 8e-18
Identities = 207/1124 (18%), Positives = 456/1124 (40%), Gaps = 155/1124 (13%)
Query: 322 SERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKD 381
SE E+ LK E + LQK + + Q ++LK + L + D
Sbjct: 855 SEVGEEVAGLKEE--------------CAQLQKALEKSEFQREELKAKQVSLTQEKNDLI 900
Query: 382 HQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCT 441
QL+A + ++E+ + + EA+ KEL + +++ E+ +L C
Sbjct: 901 LQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECF 960
Query: 442 E---QSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQ 498
E + T+ KS+ E++ E + L + E N E + K+N RA ++ Q
Sbjct: 961 ELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLN-EDISKLN--RAAKVVQEAHQQ 1017
Query: 499 VIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQK----KWTLQKETQLSNSKQEE 554
+ + EK++ +++ N+ +Q+ + L++E + + + E
Sbjct: 1018 TLDDLHMEE--------------EKLSSLSKANLKLEQQVDELEGALEQERKARMNCERE 1063
Query: 555 TTE---NIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRH 611
+ N++ R S+++ ++ + KKE++L Q++ V + +V + +
Sbjct: 1064 LHKLEGNLKLNRESMENLESSQR-HLAEELRKKELEL---SQMNSKVENEKGLVAQLQK- 1118
Query: 612 ALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERGEARAR 671
++E++ ++DL K++++ A + ER A
Sbjct: 1119 ---TVKELQTQIKDL--------KEKLEAERTTRA---------------KMERERADLT 1152
Query: 672 GEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQ-ELESLLAQQKKALAKSI 730
+ N+ + G + IT+++ + L + + E+ A KK A S+
Sbjct: 1153 QDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSL 1212
Query: 731 ------TQEKNRVKEALEEEQTRVQ-ELEERLARQKEVLESSIAHEK-----RKAKEALE 778
+ +VK+ LE++++ +Q E+++ L R +++ + EK +
Sbjct: 1213 AELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEAT 1272
Query: 779 SEKRKVQDLENHLTQQKE--ISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELEL 836
++ KV L N L QK SES + + KEA+ + + ++ T+Q E+L
Sbjct: 1273 AKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSRE---KSNFTRQIEDLRG 1329
Query: 837 KEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEER 896
+ +KE + L+ AL + + + + + +L+ TL +K MV+ R
Sbjct: 1330 QLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTL-----SKVNAEMVQWR 1384
Query: 897 LILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIE-- 954
+ + +++ +D +++++ + + Q A + + + +H ++E
Sbjct: 1385 MKYENNVIQRTEDLEDAKKE------LAIRLQEAAEAMGVANARNASLERARHQLQLELG 1438
Query: 955 GEIATL-KDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMK 1013
++ L K A + ++ Q + + K + L+D A+QKE+ + ++K
Sbjct: 1439 DALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLD---ASQKEVQALSTELLK 1495
Query: 1014 LRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDR 1073
L+ E+ LR E N+ + E+ V++ +K L+ +M ++ L+E++
Sbjct: 1496 LKNTYEESIVGQETLRRE-NKNLQEEISNLTNQVREGTKNLT----EMEKVKKLIEEEKT 1550
Query: 1074 E----LKALEEALRASQEK------HRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFS 1123
E L+ E AL ++ K L+ E E+K +K + + + + ++
Sbjct: 1551 EVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQ 1610
Query: 1124 SSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLDL 1183
SS + ++ S + V + EE + + LS ++ E K+ + + +
Sbjct: 1611 SSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKS--------LGQLQIQI 1662
Query: 1184 KNLRME-NNVQKILLDAKPDLPTLSRIEILAPQNGLCNAR-FGSAMEKSGKMDVAEALEL 1241
K+L+M+ ++ ++ D K + R L Q+ L + R E+ ++ E LE
Sbjct: 1663 KDLQMQLDDSTQLNSDLKEQVAVAERRNSLL-QSELEDLRSLQEQTERGRRLSEEELLEA 1721
Query: 1242 SEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQL 1301
+E++ L ++ L K + V+ +E + Q + + L +L
Sbjct: 1722 TERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEEL 1781
Query: 1302 GRKEELLRGYEKDVEQLRR-------------------SKVSIEMYQSQVAKLEDDIYKE 1342
+K++ + E+ E + + S+ I+ +S+V +LE ++ E
Sbjct: 1782 KKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGE 1841
Query: 1343 AEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQ 1386
A + R+E + K + + K + +MD+
Sbjct: 1842 IRRSAEAQRGARRLERCI---KELTYQAEEDKKNLSRMQTQMDK 1882
Score = 63.2 bits (152), Expect = 2e-09
Identities = 86/370 (23%), Positives = 168/370 (45%), Gaps = 31/370 (8%)
Query: 1044 VVLVQQQSKELSVLKEKMAQMSSLVEKKD---RELKALEEALRASQEKHRLQLNTEKEQK 1100
+V + +E++ LKE+ AQ+ +EK + ELKA + +L +QEK+ L L + EQ+
Sbjct: 851 LVKSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSL--TQEKNDLILQLQAEQE 908
Query: 1101 PRKKT-QTCD----TSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALS 1155
+ C+ + +Q+E + S E++ + + +G + E+ KK +
Sbjct: 909 TLANVEEQCEWLIKSKIQLE-ARVKELSERVEEEEEINSELTARGRKLEDECFELKKEID 967
Query: 1156 ELRARIKELEK-ARSPDHKDH---QNESFLDLKNLRMENNVQKILLDA-KPDLPTLSRIE 1210
+L + + EK R+ +HK + FL+ +++ N K++ +A + L L E
Sbjct: 968 DLETMLVKSEKEKRTTEHKVKNLTEEVEFLN-EDISKLNRAAKVVQEAHQQTLDDLHMEE 1026
Query: 1211 ILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLM-NIKNMSGHVSMK 1269
N + ++ ++ ALE K ++ + L L N+K SM+
Sbjct: 1027 EKLSSLSKANLKLEQQVD-----ELEGALEQERKARMNCERELHKLEGNLK--LNRESME 1079
Query: 1270 YLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQ 1329
L +R +LR+++L+L ++++N+ G +L + ++ Q++ K +E +
Sbjct: 1080 NLESSQRHLAEELRKKELEL-SQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAER 1138
Query: 1330 SQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQERE 1389
+ AK+E + ++ A L E LE + + I + K T+ L D E
Sbjct: 1139 TTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITK-----KQETKFQKLHRDMEEA 1193
Query: 1390 MLRKETSSKS 1399
L ET+S S
Sbjct: 1194 TLHFETTSAS 1203
Score = 48.5 bits (114), Expect = 4e-05
Identities = 43/248 (17%), Positives = 108/248 (43%), Gaps = 5/248 (2%)
Query: 254 IANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGY 313
+ LQ ++ +L ++ ++T + KE + + + ++ ++++SL+ Q ++
Sbjct: 1655 LGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLS 1714
Query: 314 SKVLCQTLSERN---SEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEV 370
+ L + N ++ TSL ++ + L+ D A + ++ +E+ ++ E
Sbjct: 1715 EEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEA 1774
Query: 371 SHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMK 430
++L + K K + L +++ + D + L EA++ L + QIQ +E ++
Sbjct: 1775 ANLSEELKKKQDTIAHLERTRENMEQTIT--DLQKRLAEAEQMALMGSRKQIQKLESRVR 1832
Query: 431 KLRAELRKSCTEQSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVG 490
+L EL + R R + ++L + L M + +++ ++
Sbjct: 1833 ELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQ 1892
Query: 491 QLEHFRSQ 498
Q+E +Q
Sbjct: 1893 QVEVAETQ 1900
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 126 bits (316), Expect = 2e-28
Identities = 235/1081 (21%), Positives = 468/1081 (43%), Gaps = 135/1081 (12%)
Query: 224 QDKDEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQ 283
++K+++ L + E L+D E + +I +Q L K+ E T ++E+EI+
Sbjct: 888 KEKNDLQLQVQAEAEGLAD--AEERCDQLIKTKIQ-----LEAKIKEVTERAEDEEEINA 940
Query: 284 KCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNA 343
++ AK+++ L+ + S L+K L TL++ E + +N+ +NL + A
Sbjct: 941 -------ELTAKKRK---LEDECSELKKDIDD-LELTLAKVEKEKHATENKVKNLTEEMA 989
Query: 344 ITSGMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDA 403
++ L K+ A E QQ +++ + + L + L+ L+QE
Sbjct: 990 GLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKK 1049
Query: 404 HR-ELREAQEK---ELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVEEK 459
R +L A+ K +LKL + I D+E E ++L +L+K E S + + ++ + +
Sbjct: 1050 LRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQ 1109
Query: 460 LQEDSRRKLLQLQEM-----GNRESVIKINLERA--VGQLEHFRSQVIKATYGRAKPFRD 512
LQ+ + +++E+ R S K +R+ +LE ++ +A +
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1169
Query: 513 KPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQAC 572
+ + + + E + + TL+K+ S ++ E +N+++++ L+ ++
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1229
Query: 573 MKISCCSHDLKKEVDLLQHLQVSPPVSGLQKV---VLDVLRHALSWLEEVEQLLRDLGIL 629
MK+ DL V+ VS L+K+ + D L S EE ++L+ DL
Sbjct: 1230 MKMEI--DDLASNVE-----TVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDL--- 1279
Query: 630 PSSPNKDQVQQFSGNSAVFTAGKAAGASGREGEAERG-EARARGEAQSQNQATDGREGGK 688
+ + ++Q SG + K A S + RG +A + + + Q + +
Sbjct: 1280 --TAQRGRLQTESGEFSRQLDEKEALVS----QLSRGKQAFTQQIEELKRQLEEEIKAKN 1333
Query: 689 ALEEYITQERNRA---KETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQ 745
AL + R+ +E EEE++ EL+ L++ +A+ T+ + + EE +
Sbjct: 1334 ALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELE 1393
Query: 746 TRVQELEERLARQKEVLESSIAH--EKRKAKEALESEKRKVQ-DLEN------HLTQQKE 796
++L +RL +E +E+ A K K+ L++E + D+E L +++
Sbjct: 1394 EAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453
Query: 797 ISESNIAYEKRKAKEA---MEKEKKKVQDLENRLTKQK-------EELELKEQKEDVLNN 846
+ +A K+K +E +E +K+ + L L K K ++LE +++ L
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ 1513
Query: 847 KLSDALAMVEETQK--------TKATESLKAESLALKLNETLAELETTKTKMIMVEERLI 898
++SD + E K K E K E L L E A LE + K++ R+
Sbjct: 1514 EISDLTEQIAEGGKRIHELEKIKKQVEQEKCE-LQAALEEAEASLEHEEGKIL----RIQ 1568
Query: 899 LQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHH-------K 951
L+ VK+ D + +++ +EEI + K + H + + S++ L + K
Sbjct: 1569 LELNQVKSEVDRKIAEK---DEEIDQLK---RNHIRIVESMQSTLDAEIRSRNDAIRLKK 1622
Query: 952 KIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVI 1011
K+EG++ ++ + T+ KD +DD L +Q++ L +Q +
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH--LDDALRSQED-LKEQLAM 1679
Query: 1012 MKLRKDLTEAHSRMSDLRGELN---------EKQKMELEQNVVLVQQQSKELSVLKEKMA 1062
++ R +L +A + +LR L E++ ++ + V L+ Q+ L K+K+
Sbjct: 1680 VERRANLLQA--EIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLE 1737
Query: 1063 QMSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAF 1122
S ++ + ++ L+EA A ++ + + + KK Q DTS +E +
Sbjct: 1738 TDISQMQGEMEDI--LQEARNAEEKAKKAITDAAMMAEELKKEQ--DTSAHLERM----- 1788
Query: 1123 SSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESFLD 1182
+Q+ DL +R + ++ KK + +L AR++ELE + + Q +
Sbjct: 1789 -KKNMEQTVKDLQLRL-DEAEQLALKGGKKQIQKLEARVRELE----GEVESEQKRNAEA 1842
Query: 1183 LKNLRM-ENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALEL 1241
+K LR E V+++ + D + R++ L + A KS K EA E
Sbjct: 1843 VKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKL--------QAKVKSYKRQAEEAEEQ 1894
Query: 1242 S 1242
S
Sbjct: 1895 S 1895
Score = 103 bits (257), Expect = 1e-21
Identities = 219/1140 (19%), Positives = 471/1140 (41%), Gaps = 160/1140 (14%)
Query: 353 QKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELREAQE 412
+K++ E+ Q++K+E++ +++ K+ + ++ L + L+ +++ E L +A+E
Sbjct: 852 EKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEA--EGLADAEE 909
Query: 413 KELKLCKTQIQ----------------DMEKEMKKLRAELRKSCTE-QSVISRTLREKSK 455
+ +L KT+IQ ++ E+ + +L C+E + I +K
Sbjct: 910 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 969
Query: 456 VE-EKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKP 514
VE EK +++ K L + G E++ K+ E+ Q H + T + DK
Sbjct: 970 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH------QQTLDDLQAEEDKV 1023
Query: 515 VTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQE-------ETTENIEKLRTSLD 567
T + K+ Q +D +++ L+ + + + K E E+ +IE + LD
Sbjct: 1024 NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLD 1083
Query: 568 SCQACMKISCCSHDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLG 627
+ + K E + +Q+ + LQ + ++ E E+ R
Sbjct: 1084 EKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI-----EAERASRAKA 1138
Query: 628 ILPSSPNKDQVQQFSGNSAVFTAGKAAGAS---GREGEAE-RGEARARGEAQSQNQATDG 683
S ++++ S + AG A A ++ EAE + R EA Q++AT
Sbjct: 1139 EKQRSDLSRELEEIS--ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196
Query: 684 ---REGGKALEEYITQERN--RAKETLEEERKRMQ-ELESLLAQQK---------KALAK 728
++ ++ E Q N R K+ LE+E+ M+ E++ L + + + + +
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCR 1256
Query: 729 SITQEKNRVKEALEEEQTRVQELEERLAR-------------QKEVLESSIAHEKRKAKE 775
++ + + +K EE+Q + +L + R +KE L S ++ K+ +
Sbjct: 1257 TLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQ 1316
Query: 776 ALESEKRKVQD---LENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKE 832
+E KR++++ +N L + S ++ +E E+E++ +L+ L+K
Sbjct: 1317 QIEELKRQLEEEIKAKNALAHALQSSR----HDCDLLREQYEEEQESKAELQRALSKANT 1372
Query: 833 ELELKEQKEDVLNNKLSDALAMVEETQKTK---ATESLKAESLALKLNETLAELETTKTK 889
E+ K + +DA+ EE ++ K A AE +N A LE TK +
Sbjct: 1373 EVAQWRTKYE------TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQR 1426
Query: 890 MIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQ-HAQTIVSLEEKLQKVTQ 948
+ E L+L + A + ++ F++ + E+K++ ++ HA+ S +E T+
Sbjct: 1427 LQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTE 1486
Query: 949 HHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDL-LAAQKEILSQ 1007
K +L + +E + ++ +TE A+ H ++ + ++E
Sbjct: 1487 LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCEL 1546
Query: 1008 QEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQ-MSS 1066
Q + + L ++ ++ ELN+ K E+++ + ++ +E+ LK + + S
Sbjct: 1547 QAALEEAEASLEHEEGKILRIQLELNQ-VKSEVDRKIA---EKDEEIDQLKRNHIRIVES 1602
Query: 1067 LVEKKDRELKALEEALRASQE------KHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTE 1120
+ D E+++ +A+R ++ + +QLN +T ++
Sbjct: 1603 MQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662
Query: 1121 AFSSSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQNESF 1180
+ + Q+ + + R ++Q + + ELRA +++ E++R ++
Sbjct: 1663 LDDALRSQEDLKEQLAMVE--RRANLLQAE---IEELRATLEQTERSRKIAEQE------ 1711
Query: 1181 LDLKNLRMENNVQKILLDAKPDLPTLSRIEILAPQN-GLCNAR---FGSAMEKSGKM--- 1233
LLDA R+++L QN L N + + G+M
Sbjct: 1712 ---------------LLDAS------ERVQLLHTQNTSLINTKKKLETDISQMQGEMEDI 1750
Query: 1234 --DVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVN-QLRQRDLDLV 1290
+ A E ++K D + L ++ S H+ ER K N + +DL L
Sbjct: 1751 LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL--------ERMKKNMEQTVKDLQLR 1802
Query: 1291 FDKITQL-----KNQLGRKEELLRGYEKDVE-QLRRSKVSIEMYQSQVAKLEDDIYKEAE 1344
D+ QL K Q+ + E +R E +VE + +R+ +++ + ++++ Y+ E
Sbjct: 1803 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEE 1862
Query: 1345 EK---ALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREMLRKETSSKSSQ 1401
++ L++ +++++ ++ KR +Q K+ E E + SQ
Sbjct: 1863 DRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQ 1922
Score = 92.4 bits (228), Expect = 3e-18
Identities = 150/782 (19%), Positives = 336/782 (42%), Gaps = 98/782 (12%)
Query: 674 AQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQE 733
A+++ + +E + +++ + + + KE LEE+ + + ++ L Q +A A+ +
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKE-LEEKMVTLLKEKNDLQLQVQAEAEGLADA 907
Query: 734 KNRVKEALEEE---QTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENH 790
+ R + ++ + + +++E+ ER A +E + + + +KRK ++ K+ + DLE
Sbjct: 908 EERCDQLIKTKIQLEAKIKEVTER-AEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 966
Query: 791 LTQ---QKEISES---NIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVL 844
L + +K +E+ N+ E E + K K+ + L+ + ++L+ +E K + L
Sbjct: 967 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026
Query: 845 NNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMV 904
A ++ Q+ E + L++ +LE K K+ E L L Q+ +
Sbjct: 1027 TK------AKIKLEQQVDDLEGSLEQEKKLRM-----DLERAKRKL---EGDLKLAQESI 1072
Query: 905 KALQDEQESQRHGFEE---EIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLK 961
+++E++ ++ EI + +I+ + L++K++++ +++E EI
Sbjct: 1073 MDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA-- 1130
Query: 962 DNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEV-IMKLRKDLTE 1020
+ K E+ + L + E S + +AQ E+ ++E K+R+DL E
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISER----LEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1186
Query: 1021 A-----------HSRMSDLRGELNE------KQKMELEQNVVLVQQQSKELSVLKEKMAQ 1063
A + +D EL E + K +LE+ ++ + +L+ E +++
Sbjct: 1187 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSK 1246
Query: 1064 MSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFS 1123
+EK R L+ L++ +E+ + +N Q+ R +T++ + S Q++
Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ 1306
Query: 1124 SSQEQQSFSDLGVRCKGSRHEEVIQRQKKALSE-LRARIKELEKARSPDHKDHQNESFLD 1182
S+ +Q+F+ K EE+ + K AL+ L++ + + R + + + ES +
Sbjct: 1307 LSRGKQAFTQQIEELKRQLEEEI--KAKNALAHALQSSRHDCDLLR--EQYEEEQESKAE 1362
Query: 1183 LKNLRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDV-AEALEL 1241
L+ + N + K + + R E L R +A E ++ +LE
Sbjct: 1363 LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK 1422
Query: 1242 S--------EKLYLDMSKTLGSLMNI----KNMSGHVSMKYLSRQEREKVNQLRQRDLDL 1289
+ E L LD+ +T + + +N ++ +E + Q++
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS 1482
Query: 1290 VFDKITQLKNQLGRKEELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDI---------- 1339
+ ++ ++KN YE+ ++QL K + Q +++ L + I
Sbjct: 1483 LGTELFKIKN----------AYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL 1532
Query: 1340 --------YKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQEREML 1391
++ E +A L+EA +EH+ + RI + Q K + + D+E + L
Sbjct: 1533 EKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQL 1592
Query: 1392 RK 1393
++
Sbjct: 1593 KR 1594
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.125 0.331
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,905,943
Number of Sequences: 37866
Number of extensions: 2518927
Number of successful extensions: 49835
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 702
Number of HSP's successfully gapped in prelim test: 1812
Number of HSP's that attempted gapping in prelim test: 16160
Number of HSP's gapped (non-prelim): 15489
length of query: 1412
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1297
effective length of database: 13,892,928
effective search space: 18019127616
effective search space used: 18019127616
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.