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Search of human proteins with 189217897
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|189217897 syntaxin binding protein 5 (tomosyn) isoform a
[Homo sapiens]
(1115 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|189217897 syntaxin binding protein 5 (tomosyn) isoform a [Hom... 2266 0.0
gi|189217915 syntaxin binding protein 5 (tomosyn) isoform b [Hom... 2248 0.0
gi|149363700 syntaxin binding protein 5-like [Homo sapiens] 1555 0.0
gi|73427803 lethal giant larvae homolog 2 isoform c [Homo sapiens] 374 e-103
gi|62739161 lethal giant larvae homolog 2 isoform a [Homo sapiens] 374 e-103
gi|62912476 lethal giant larvae homolog 1 [Homo sapiens] 356 6e-98
gi|62739163 lethal giant larvae homolog 2 isoform b [Homo sapiens] 190 6e-48
gi|21426793 amisyn [Homo sapiens] 49 3e-05
gi|17402902 guanine nucleotide binding protein beta-subunit-like... 48 6e-05
gi|16418439 WD repeat and FYVE domain containing 2 [Homo sapiens] 46 2e-04
gi|13376840 WD repeat domain 61 [Homo sapiens] 43 0.002
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 42 0.004
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 42 0.004
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 42 0.004
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 42 0.004
gi|55769546 PAK1 interacting protein 1 [Homo sapiens] 40 0.009
gi|18482373 WD repeat and FYVE domain containing 1 [Homo sapiens] 40 0.012
gi|222080092 WD repeat domain 91 [Homo sapiens] 40 0.016
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens] 40 0.016
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens] 40 0.016
gi|19913367 transducin beta-like 1Y [Homo sapiens] 40 0.016
gi|19913365 transducin beta-like 1Y [Homo sapiens] 40 0.016
gi|15150805 transducin beta-like 1Y [Homo sapiens] 40 0.016
gi|225543215 antigen identified by monoclonal antibody Ki-67 iso... 39 0.021
gi|103472005 antigen identified by monoclonal antibody Ki-67 iso... 39 0.021
gi|189571685 WD repeat, sterile alpha motif and U-box domain con... 39 0.021
gi|189571683 WD repeat, sterile alpha motif and U-box domain con... 39 0.021
gi|189571681 WD repeat, sterile alpha motif and U-box domain con... 39 0.021
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 39 0.027
gi|14149987 WD repeat domain 24 [Homo sapiens] 39 0.027
>gi|189217897 syntaxin binding protein 5 (tomosyn) isoform a [Homo
sapiens]
Length = 1115
Score = 2266 bits (5872), Expect = 0.0
Identities = 1115/1115 (100%), Positives = 1115/1115 (100%)
Query: 1 MRKFNIRKVLDGLTAGSSSASQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQP 60
MRKFNIRKVLDGLTAGSSSASQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQP
Sbjct: 1 MRKFNIRKVLDGLTAGSSSASQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQP 60
Query: 61 SALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADD 120
SALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADD
Sbjct: 61 SALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADD 120
Query: 121 TLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYV 180
TLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYV
Sbjct: 121 TLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYV 180
Query: 181 IMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAI 240
IMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAI
Sbjct: 181 IMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAI 240
Query: 241 HSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKPILKVEF 300
HSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKPILKVEF
Sbjct: 241 HSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKPILKVEF 300
Query: 301 KTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQ 360
KTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQ
Sbjct: 301 KTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQ 360
Query: 361 EPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVG 420
EPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVG
Sbjct: 361 EPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVG 420
Query: 421 ARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSK 480
ARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSK
Sbjct: 421 ARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSK 480
Query: 481 VFEKSRNKDDRPNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVITEVI 540
VFEKSRNKDDRPNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVITEVI
Sbjct: 481 VFEKSRNKDDRPNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVITEVI 540
Query: 541 PMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSSSSSDGLRDNVPCL 600
PMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSSSSSDGLRDNVPCL
Sbjct: 541 PMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSSSSSDGLRDNVPCL 600
Query: 601 KVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVFGNCNGIAMVDYLQK 660
KVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVFGNCNGIAMVDYLQK
Sbjct: 601 KVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVFGNCNGIAMVDYLQK 660
Query: 661 AVLLNLGTIELYGSNDPYRREPRSPRKSRQPSGAGLCDISEGTVVPEDRCKSPTSAKMSR 720
AVLLNLGTIELYGSNDPYRREPRSPRKSRQPSGAGLCDISEGTVVPEDRCKSPTSAKMSR
Sbjct: 661 AVLLNLGTIELYGSNDPYRREPRSPRKSRQPSGAGLCDISEGTVVPEDRCKSPTSAKMSR 720
Query: 721 KLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESREAISALHFCETFTRKTDSSPSPCLW 780
KLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESREAISALHFCETFTRKTDSSPSPCLW
Sbjct: 721 KLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESREAISALHFCETFTRKTDSSPSPCLW 780
Query: 781 VGTTLGTVLVIALNLPPGGEQRLLQPVIVSPSGTILRLKGAILRMAFLDTTGCLIPPAYE 840
VGTTLGTVLVIALNLPPGGEQRLLQPVIVSPSGTILRLKGAILRMAFLDTTGCLIPPAYE
Sbjct: 781 VGTTLGTVLVIALNLPPGGEQRLLQPVIVSPSGTILRLKGAILRMAFLDTTGCLIPPAYE 840
Query: 841 PWREHNVPEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICSEKQAKVISLPTQNCAYK 900
PWREHNVPEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICSEKQAKVISLPTQNCAYK
Sbjct: 841 PWREHNVPEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICSEKQAKVISLPTQNCAYK 900
Query: 901 QNITETSFVLRGDIVALSNSICLACFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTF 960
QNITETSFVLRGDIVALSNSICLACFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTF
Sbjct: 901 QNITETSFVLRGDIVALSNSICLACFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTF 960
Query: 961 CFTNNGQALYLVSPTEIQRLTYSQETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGA 1020
CFTNNGQALYLVSPTEIQRLTYSQETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGA
Sbjct: 961 CFTNNGQALYLVSPTEIQRLTYSQETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGA 1020
Query: 1021 QSLDREELFGESSSGKASRSLAQHIPGPGGIEGVKGAASGVVGELARARLALDERGQKLG 1080
QSLDREELFGESSSGKASRSLAQHIPGPGGIEGVKGAASGVVGELARARLALDERGQKLG
Sbjct: 1021 QSLDREELFGESSSGKASRSLAQHIPGPGGIEGVKGAASGVVGELARARLALDERGQKLG 1080
Query: 1081 DLEERTAAMLSSAESFSKHAHEIMLKYKDKKWYQF 1115
DLEERTAAMLSSAESFSKHAHEIMLKYKDKKWYQF
Sbjct: 1081 DLEERTAAMLSSAESFSKHAHEIMLKYKDKKWYQF 1115
>gi|189217915 syntaxin binding protein 5 (tomosyn) isoform b [Homo
sapiens]
Length = 1151
Score = 2248 bits (5825), Expect = 0.0
Identities = 1115/1151 (96%), Positives = 1115/1151 (96%), Gaps = 36/1151 (3%)
Query: 1 MRKFNIRKVLDGLTAGSSSASQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQP 60
MRKFNIRKVLDGLTAGSSSASQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQP
Sbjct: 1 MRKFNIRKVLDGLTAGSSSASQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQP 60
Query: 61 SALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADD 120
SALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADD
Sbjct: 61 SALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADD 120
Query: 121 TLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYV 180
TLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYV
Sbjct: 121 TLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYV 180
Query: 181 IMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAI 240
IMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAI
Sbjct: 181 IMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAI 240
Query: 241 HSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKPILKVEF 300
HSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKPILKVEF
Sbjct: 241 HSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKPILKVEF 300
Query: 301 KTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQ 360
KTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQ
Sbjct: 301 KTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQ 360
Query: 361 EPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVG 420
EPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVG
Sbjct: 361 EPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVG 420
Query: 421 ARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSK 480
ARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSK
Sbjct: 421 ARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSK 480
Query: 481 VFEKSRNKDDRPNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVITEVI 540
VFEKSRNKDDRPNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVITEVI
Sbjct: 481 VFEKSRNKDDRPNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVITEVI 540
Query: 541 PMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSSSSSDGLRDNVPCL 600
PMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSSSSSDGLRDNVPCL
Sbjct: 541 PMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSSSSSDGLRDNVPCL 600
Query: 601 KVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVFGNCNGIAMVDYLQK 660
KVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVFGNCNGIAMVDYLQK
Sbjct: 601 KVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVFGNCNGIAMVDYLQK 660
Query: 661 AVLLNLGTIELYGSNDPYRREPRSPRKSRQPSGAGLCDISEGTVVPEDRCKSPTS----- 715
AVLLNLGTIELYGSNDPYRREPRSPRKSRQPSGAGLCDISEGTVVPEDRCKSPTS
Sbjct: 661 AVLLNLGTIELYGSNDPYRREPRSPRKSRQPSGAGLCDISEGTVVPEDRCKSPTSGSSSP 720
Query: 716 -------------------------------AKMSRKLSLPTDLKPDLDVKDNSFSRSRS 744
AKMSRKLSLPTDLKPDLDVKDNSFSRSRS
Sbjct: 721 HNSDDEQKMNNFIEKVKTKSRKFSKMVANDIAKMSRKLSLPTDLKPDLDVKDNSFSRSRS 780
Query: 745 SSVTSIDKESREAISALHFCETFTRKTDSSPSPCLWVGTTLGTVLVIALNLPPGGEQRLL 804
SSVTSIDKESREAISALHFCETFTRKTDSSPSPCLWVGTTLGTVLVIALNLPPGGEQRLL
Sbjct: 781 SSVTSIDKESREAISALHFCETFTRKTDSSPSPCLWVGTTLGTVLVIALNLPPGGEQRLL 840
Query: 805 QPVIVSPSGTILRLKGAILRMAFLDTTGCLIPPAYEPWREHNVPEEKDEKEKLKKRRPVS 864
QPVIVSPSGTILRLKGAILRMAFLDTTGCLIPPAYEPWREHNVPEEKDEKEKLKKRRPVS
Sbjct: 841 QPVIVSPSGTILRLKGAILRMAFLDTTGCLIPPAYEPWREHNVPEEKDEKEKLKKRRPVS 900
Query: 865 VSPSSSQEISENQYAVICSEKQAKVISLPTQNCAYKQNITETSFVLRGDIVALSNSICLA 924
VSPSSSQEISENQYAVICSEKQAKVISLPTQNCAYKQNITETSFVLRGDIVALSNSICLA
Sbjct: 901 VSPSSSQEISENQYAVICSEKQAKVISLPTQNCAYKQNITETSFVLRGDIVALSNSICLA 960
Query: 925 CFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFTNNGQALYLVSPTEIQRLTYSQ 984
CFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFTNNGQALYLVSPTEIQRLTYSQ
Sbjct: 961 CFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFTNNGQALYLVSPTEIQRLTYSQ 1020
Query: 985 ETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQH 1044
ETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQH
Sbjct: 1021 ETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQH 1080
Query: 1045 IPGPGGIEGVKGAASGVVGELARARLALDERGQKLGDLEERTAAMLSSAESFSKHAHEIM 1104
IPGPGGIEGVKGAASGVVGELARARLALDERGQKLGDLEERTAAMLSSAESFSKHAHEIM
Sbjct: 1081 IPGPGGIEGVKGAASGVVGELARARLALDERGQKLGDLEERTAAMLSSAESFSKHAHEIM 1140
Query: 1105 LKYKDKKWYQF 1115
LKYKDKKWYQF
Sbjct: 1141 LKYKDKKWYQF 1151
>gi|149363700 syntaxin binding protein 5-like [Homo sapiens]
Length = 1186
Score = 1555 bits (4026), Expect = 0.0
Identities = 769/1196 (64%), Positives = 937/1196 (78%), Gaps = 91/1196 (7%)
Query: 1 MRKFNIRKVLDGLTA-----GSSSASQQ-----QQQQHPPGNR---EPEIQETLQSEHFQ 47
M+KFN RKVLDGLTA GSSS S HP G EIQETL SE+FQ
Sbjct: 1 MKKFNFRKVLDGLTASSPGSGSSSGSNSGGGAGSGSVHPAGTAGVLREEIQETLTSEYFQ 60
Query: 48 LCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFL 107
+CKTVRHGFP+QP+ALAFDPVQKILA+GT+TGA+R+ GRPGV+CYCQH+SGAAV+QLQFL
Sbjct: 61 ICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHESGAAVLQLQFL 120
Query: 108 INEGALVSALADDTLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIH 167
INEGALVSA +DDTLHLWNLRQKRPAILHSLKF RER+T+CHLPFQSKWLYVGTERGN H
Sbjct: 121 INEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTH 180
Query: 168 IVNVESFTLSGYVIMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKS 227
IVN+ESF LSGYVIMWNKAIELS+K+HPGPVVH+SD+P DEGKLLIG+E+GTVV WDLKS
Sbjct: 181 IVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKS 240
Query: 228 KKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPAKPVQTITPHGKQLKDGK 287
K+A+ R YDEAIHS+ WHHEGKQF+CSHSDG+LT+WN++SP++P QT PHGK ++G+
Sbjct: 241 KRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLKSPSRPFQTTIPHGKSQREGR 300
Query: 288 KPEPCKPILKVEFKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDF 347
K E CKPILKVE+KT ++ EPFII SGGLSYD RRP LT+MHGK+ VLEMD+ IV+F
Sbjct: 301 KSESCKPILKVEYKTCKNSEPFIIFSGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEF 360
Query: 348 LTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFAD 407
LTLCETPYPN+FQEPYAVVVLLEKDL+++DL Q+ +PIFENPYP+ IHESPVTC YFAD
Sbjct: 361 LTLCETPYPNEFQEPYAVVVLLEKDLIVVDLTQSNFPIFENPYPMDIHESPVTCTAYFAD 420
Query: 408 CPVDLIPALYSVGARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASA 467
CP DLI LYS+G + K+QGYS KEWPI+GG W LGAQ+YPEIIITGHADGS+KFWDASA
Sbjct: 421 CPPDLILVLYSIGVKHKKQGYSNKEWPISGGAWNLGAQTYPEIIITGHADGSIKFWDASA 480
Query: 468 ITLQVLYKLKTSKVFEKSRNKDDRPNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVII 527
ITLQ+LYKLKTSKVFEK + + + +IV+EDP+AIQ+I WCPESR+ C++GVSA+VII
Sbjct: 481 ITLQMLYKLKTSKVFEKQKVGEGKQTCEIVEEDPFAIQMIYWCPESRIFCVSGVSAYVII 540
Query: 528 YRFSKQEVITEVIPMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSS 587
Y+FS+ E+ TE++ LEVRL Y++ D+ TPE E PP P S P ST++
Sbjct: 541 YKFSRHEITTEIV-SLEVRLQYDVEDIITPEPETSPPFPDL---SAQLPSSRSLSGSTNT 596
Query: 588 SSSDGL-RDNVPCLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVF 646
+S+G+ +D++PCL VK P++ PGYQ ELVIQLVWV GEPPQQITSLAV+S+YG+V F
Sbjct: 597 VASEGVTKDSIPCLNVKTRPVRMPPGYQAELVIQLVWVDGEPPQQITSLAVSSAYGIVAF 656
Query: 647 GNCNGIAMVDYLQKAVLLNLGTIELYGSNDPYRREPRSPRKSRQ---------------- 690
GNCNG+A+VD++QK VLL++GTI+LY S+D Y+R+PRSPRK++Q
Sbjct: 657 GNCNGLAVVDFIQKTVLLSMGTIDLYRSSDLYQRQPRSPRKNKQFIADNFCMRGLSNFYP 716
Query: 691 -------PSGAGLCDISEGTVVPE-DRCKSPTS--------------------------A 716
S L ++++ V E +RCKSPTS +
Sbjct: 717 DLTKRIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVS 776
Query: 717 KMSR-----------------KLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESREAIS 759
K++R ++SLP + + ++NS++RSRSSS++SIDK+S+EAI+
Sbjct: 777 KVNRWGPGRPPFRKAQSAACMEISLPVTTEEN---RENSYNRSRSSSISSIDKDSKEAIT 833
Query: 760 ALHFCETFTRKTDSSPSPCLWVGTTLGTVLVIALNLPPGGEQRLLQPVIVSPSGTILRLK 819
AL+F ++F RK DS+ SPCL+VGT+LG VL+I+LNLP EQR +PV+V PSGT L LK
Sbjct: 834 ALYFMDSFARKNDSTISPCLFVGTSLGMVLIISLNLPLADEQRFTEPVMVLPSGTFLSLK 893
Query: 820 GAILRMAFLDTTGCLIPPAYEPWREHNVPEEKDEKEKLKKRRPVSVSPSSSQEISENQYA 879
GA+L + +D G L+ P YE WR+ P DE EK +R+ V S S+SQEI ++QY
Sbjct: 894 GAVLTFSCMDRMGGLMQPPYEVWRD---PNNIDENEKSWRRKVVMNSSSASQEIGDHQYT 950
Query: 880 VICSEKQAKVISLPTQNCAYKQNITETSFVLRGDIVALSNSICLACFCANGHIMTFSLPS 939
+ICSEKQAKV SLP+Q C Y NITETSF+L+ ++V + +S CLACFCANGHIM SLPS
Sbjct: 951 IICSEKQAKVFSLPSQTCLYVHNITETSFILQANVVVMCSSACLACFCANGHIMIMSLPS 1010
Query: 940 LRPLLDVYYLPLTNMRIARTFCFTNNGQALYLVSPTEIQRLTYSQETCENLQEMLGELFT 999
LRP+LDV YLPLT+MRIARTFCFTN GQALYLVSPTEIQRLTYSQE C+NLQ+MLG+LFT
Sbjct: 1011 LRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQEMCDNLQDMLGDLFT 1070
Query: 1000 PVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQHIPGPGGIEGVKGAAS 1059
P+ETPEA NRGF KGLFGG Q+ DREELFGE+S+GKASRSLAQHIPGPG IEG+KGAA
Sbjct: 1071 PIETPEAQNRGFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPGPGSIEGMKGAAG 1130
Query: 1060 GVVGELARARLALDERGQKLGDLEERTAAMLSSAESFSKHAHEIMLKYKDKKWYQF 1115
GV+GEL RAR+ALDERGQ+LG+LEE+TA M++SAE+FSKHAHE+MLKYKDKKWYQF
Sbjct: 1131 GVMGELTRARIALDERGQRLGELEEKTAGMMTSAEAFSKHAHELMLKYKDKKWYQF 1186
>gi|73427803 lethal giant larvae homolog 2 isoform c [Homo sapiens]
Length = 1020
Score = 374 bits (959), Expect = e-103
Identities = 291/1012 (28%), Positives = 464/1012 (45%), Gaps = 164/1012 (16%)
Query: 37 IQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHD 96
++E L+ + FQ KTV HGFP+QPSAL + P +ILA+GT++GA++L+G PGVE H
Sbjct: 12 VRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQ 71
Query: 97 SGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPA--ILHSLKFCRE----------R 144
AV Q+ L + LV+ L D++LHLW+L+ K A + F +
Sbjct: 72 ENNAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQ 131
Query: 145 VTFCHLPFQS-KWLYVGTERGNIHIVNVESF------TLSGYVIMWNKAIELSSKSHPGP 197
+T LP S + LY+GTE GN+ +V + +F T+S ++ E +
Sbjct: 132 ITVV-LPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEM 190
Query: 198 VVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAWHHEGKQFICSHS 257
V + ++P D ++LIG+ G VV+WDL+ + Y + + + ++ W +G+ + HS
Sbjct: 191 VEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHS 250
Query: 258 DGTLTIWNVRSPAK---PVQTITPHGKQLKDGKKPEPCKPILKVEFKTTRSGEPFIILSG 314
DG+ W V S A+ P++++ P+G P PCK I ++ + TTR G PF I G
Sbjct: 251 DGSYCQWPVSSEAQQPEPLRSLVPYG--------PFPCKAITRILWLTTRQGLPFTIFQG 302
Query: 315 GLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQEPYAVVVLLEKDLV 374
G+ + G R C++V+H + ++ F L E F +PYA+VVL E++LV
Sbjct: 303 GMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELV 362
Query: 375 LIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVGARQKRQGYSKKEWP 434
+IDL G+P + PY S+H S +TC + ++ P+ L + + G+RQ +S EWP
Sbjct: 363 VIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAH-FSTMEWP 421
Query: 435 INGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSKVFEKSRNKDDRPNT 494
I+GG A ++++TGH DG+V+FWDAS + L++LYKL T +VF + ++ +
Sbjct: 422 IDGGTSLTPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTDPNENFSA 481
Query: 495 DIVDE----------DPYA------IQIISWCPESRMLCIAGVSAHVIIYRFSKQEVITE 538
DE DPY+ IQ I C S L +AG + V++ + E +
Sbjct: 482 QGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELN-DEAAEQ 540
Query: 539 VIPMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSSSSSDGLRDNVP 598
+ +E LL + E+
Sbjct: 541 AVEQVEADLLQDQEGYRWKGHER------------------------------------- 563
Query: 599 CLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVFGNCNGIAMVDYL 658
L ++ P++ PG+Q +++Q +PP +TSLA++S + LV FG +G + D+
Sbjct: 564 -LAARSGPVRFEPGFQPFVLVQC-----QPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQ 617
Query: 659 Q------KAVLLNLGTIELYGS-----------NDPYRREPRSPRKSRQPSGAGLCDISE 701
Q K L + L G +RR RS SR+ AG
Sbjct: 618 QRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRMRRSRVSSRKRHPAG------ 671
Query: 702 GTVVPEDRCKSPTSAKMSRKLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESREAISAL 761
P + SAK R +L P V+ +RS S T + L
Sbjct: 672 ----PPGEAQE-GSAKAERPGLQNMELAP---VQRKIEARSAEDSFTGF-------VRTL 716
Query: 762 HFCETFTRKTDSSPSPCLWVGTTLGTVLVIALNLPPGGEQRLLQPVIVSPSGTI-LRLKG 820
+F +T+ K S P LW GT GT+ +L +PP E+R+ +PV + I L +
Sbjct: 717 YFADTYL-KDSSRHCPSLWAGTNGGTIYAFSLRVPP-AERRMDEPVRAEQAKEIQLMHRA 774
Query: 821 AILRMAFLDTTGCLIPPAYEPWREHNVPEEKDEKEKLKKRRPVSVSPSSSQEISENQYAV 880
++ + LD H+VP L + V+ S S ++ + +
Sbjct: 775 PVVGILVLD--------------GHSVP--------LPEPLEVAHDLSKSPDMQGSHQLL 812
Query: 881 ICSEKQAKVISLPTQNCAYKQNIT--ETSFVLRGDIVALSNSIC-------LACFCANGH 931
+ SE+Q KV +LP + K +T E S V R + + LA G
Sbjct: 813 VVSEEQFKVFTLPKVSAKLKLKLTALEGSRVRRVSVAHFGSRRAEDYGEHHLAVLTNLGD 872
Query: 932 IMTFSLPSLRPLLDVYYLPLTNMRIARTFCFTNNGQALYLVSPTEIQRLTYS 983
I SLP L+P + + ++ + FT GQ YL+SP+E +R + S
Sbjct: 873 IQVVSLPLLKPQVRYSCIRREDVSGIASCVFTKYGQGFYLISPSEFERFSLS 924
>gi|62739161 lethal giant larvae homolog 2 isoform a [Homo sapiens]
Length = 1015
Score = 374 bits (959), Expect = e-103
Identities = 291/1012 (28%), Positives = 464/1012 (45%), Gaps = 164/1012 (16%)
Query: 37 IQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHD 96
++E L+ + FQ KTV HGFP+QPSAL + P +ILA+GT++GA++L+G PGVE H
Sbjct: 12 VRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQ 71
Query: 97 SGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPA--ILHSLKFCRE----------R 144
AV Q+ L + LV+ L D++LHLW+L+ K A + F +
Sbjct: 72 ENNAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQ 131
Query: 145 VTFCHLPFQS-KWLYVGTERGNIHIVNVESF------TLSGYVIMWNKAIELSSKSHPGP 197
+T LP S + LY+GTE GN+ +V + +F T+S ++ E +
Sbjct: 132 ITVV-LPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEM 190
Query: 198 VVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAWHHEGKQFICSHS 257
V + ++P D ++LIG+ G VV+WDL+ + Y + + + ++ W +G+ + HS
Sbjct: 191 VEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHS 250
Query: 258 DGTLTIWNVRSPAK---PVQTITPHGKQLKDGKKPEPCKPILKVEFKTTRSGEPFIILSG 314
DG+ W V S A+ P++++ P+G P PCK I ++ + TTR G PF I G
Sbjct: 251 DGSYCQWPVSSEAQQPEPLRSLVPYG--------PFPCKAITRILWLTTRQGLPFTIFQG 302
Query: 315 GLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQEPYAVVVLLEKDLV 374
G+ + G R C++V+H + ++ F L E F +PYA+VVL E++LV
Sbjct: 303 GMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELV 362
Query: 375 LIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVGARQKRQGYSKKEWP 434
+IDL G+P + PY S+H S +TC + ++ P+ L + + G+RQ +S EWP
Sbjct: 363 VIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAH-FSTMEWP 421
Query: 435 INGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSKVFEKSRNKDDRPNT 494
I+GG A ++++TGH DG+V+FWDAS + L++LYKL T +VF + ++ +
Sbjct: 422 IDGGTSLTPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTDPNENFSA 481
Query: 495 DIVDE----------DPYA------IQIISWCPESRMLCIAGVSAHVIIYRFSKQEVITE 538
DE DPY+ IQ I C S L +AG + V++ + E +
Sbjct: 482 QGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELN-DEAAEQ 540
Query: 539 VIPMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSSSSSDGLRDNVP 598
+ +E LL + E+
Sbjct: 541 AVEQVEADLLQDQEGYRWKGHER------------------------------------- 563
Query: 599 CLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVFGNCNGIAMVDYL 658
L ++ P++ PG+Q +++Q +PP +TSLA++S + LV FG +G + D+
Sbjct: 564 -LAARSGPVRFEPGFQPFVLVQC-----QPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQ 617
Query: 659 Q------KAVLLNLGTIELYGS-----------NDPYRREPRSPRKSRQPSGAGLCDISE 701
Q K L + L G +RR RS SR+ AG
Sbjct: 618 QRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRMRRSRVSSRKRHPAG------ 671
Query: 702 GTVVPEDRCKSPTSAKMSRKLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESREAISAL 761
P + SAK R +L P V+ +RS S T + L
Sbjct: 672 ----PPGEAQE-GSAKAERPGLQNMELAP---VQRKIEARSAEDSFTGF-------VRTL 716
Query: 762 HFCETFTRKTDSSPSPCLWVGTTLGTVLVIALNLPPGGEQRLLQPVIVSPSGTI-LRLKG 820
+F +T+ K S P LW GT GT+ +L +PP E+R+ +PV + I L +
Sbjct: 717 YFADTYL-KDSSRHCPSLWAGTNGGTIYAFSLRVPP-AERRMDEPVRAEQAKEIQLMHRA 774
Query: 821 AILRMAFLDTTGCLIPPAYEPWREHNVPEEKDEKEKLKKRRPVSVSPSSSQEISENQYAV 880
++ + LD H+VP L + V+ S S ++ + +
Sbjct: 775 PVVGILVLD--------------GHSVP--------LPEPLEVAHDLSKSPDMQGSHQLL 812
Query: 881 ICSEKQAKVISLPTQNCAYKQNIT--ETSFVLRGDIVALSNSIC-------LACFCANGH 931
+ SE+Q KV +LP + K +T E S V R + + LA G
Sbjct: 813 VVSEEQFKVFTLPKVSAKLKLKLTALEGSRVRRVSVAHFGSRRAEDYGEHHLAVLTNLGD 872
Query: 932 IMTFSLPSLRPLLDVYYLPLTNMRIARTFCFTNNGQALYLVSPTEIQRLTYS 983
I SLP L+P + + ++ + FT GQ YL+SP+E +R + S
Sbjct: 873 IQVVSLPLLKPQVRYSCIRREDVSGIASCVFTKYGQGFYLISPSEFERFSLS 924
>gi|62912476 lethal giant larvae homolog 1 [Homo sapiens]
Length = 1064
Score = 356 bits (914), Expect = 6e-98
Identities = 285/1023 (27%), Positives = 456/1023 (44%), Gaps = 151/1023 (14%)
Query: 38 QETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDS 97
+E L+ E F KTV HGFP QPSALAFDP +I+A+GT++GA++++G PGVE H
Sbjct: 15 REKLKQELFAFNKTVEHGFPNQPSALAFDPELRIMAIGTRSGAVKIYGAPGVEFTGLHRD 74
Query: 98 GAAVIQLQFLINEGALVSALADDTLHLWNLRQ----------------KRPAILH-SLKF 140
A V Q+ FL +G L+S L D +LHLW + RP S
Sbjct: 75 AATVTQMHFLTGQGRLLSLLDDSSLHLWEIVHHNGCAHLEEALSFQLPSRPGFDGASAPL 134
Query: 141 CRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTL-SGYVIMWNKAIELSSKSHP---- 195
RVT L +GTE ++ ++V + TL G + + + +
Sbjct: 135 SLTRVTVVLLVAAGDIAALGTEGSSVFFLDVTTLTLLEGQTLAPGEVLRSVPDDYRCGKA 194
Query: 196 -GPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAWHHEGKQFIC 254
GPV + + D K+LIG+ G +V+W+ S+ D+ + ++ + S+ W + +
Sbjct: 195 LGPVESLQGHLRDPTKILIGYSRGLLVIWNQASQCVDHIFLGNQQLESLCWGRDSSTVVS 254
Query: 255 SHSDGTLTIWNVRSPA----KPVQTITPHGKQLKDGKKPEPCKPILKVEFKTTRSGEPFI 310
SHSDG+ +W+V + + +P TP+G P PCK I K+ ++ SG FI
Sbjct: 255 SHSDGSYAVWSVDAGSFPTLQPTVATTPYG--------PFPCKAINKILWRNCESGGHFI 306
Query: 311 ILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQEPYAVVVLLE 370
I SGG+ + G R C++V+ ++ L+ I+DF T+ T ++F +P A+ VLLE
Sbjct: 307 IFSGGMPRASYGDRHCVSVLRAETLVTLDFTSRIIDFFTVHSTRPEDEFDDPQALAVLLE 366
Query: 371 KDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVGARQKRQGYSK 430
++LV++DL G+P PY +H S +TC + A P L + S G +Q Q S
Sbjct: 367 EELVVLDLQTPGWPAVPAPYLAPLHSSAITCSAHVASVPAKLWARIVSAGEQQSPQPVSS 426
Query: 431 K-EWPINGGNWGLGAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSKVFE------ 483
WPI GG S +++TGH DG+V+FWDAS + L+ LYKL T+ +F+
Sbjct: 427 ALSWPITGGRNLAQEPSQRGLLLTGHEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEHA 486
Query: 484 ----KSRNKDDRPNTDIVDEDPYA------IQIISWCPESRMLCIAGVSAHVIIYRFS-- 531
++ D P + DPY+ +Q ++ C + + +AG + V++ S
Sbjct: 487 DSLAQAAEDDWPPFRKVGCFDPYSDDPRLGVQKVALCKYTAQMVVAGTAGQVLVLELSDV 546
Query: 532 --KQEVITEVIPMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSSSS 589
+Q V +I +L+ R + T +G +
Sbjct: 547 PVEQAVSVAIIDLLQDR------EGFTWKGHER--------------------------- 573
Query: 590 SDGLRDNVPCLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLAVNSSYGLVVFGNC 649
L + PL G+Q +++Q + PP +T++ +++ + LV FG
Sbjct: 574 ----------LSPRTGPLPWPAGFQPRVLVQCL-----PPAAVTAVTLHTEWSLVAFGTS 618
Query: 650 NGIAMVDYLQKAVLLNLGTIELYGSNDPYRRE-PRSPRKSRQPS-GAGLCDISEGTVVPE 707
+G + DY +K+ +L T+ ND E P S KS + S I + V +
Sbjct: 619 HGFGLFDYQRKSPVLARCTLH---PNDSLAMEGPLSRVKSLKKSLRQSFRRIRKSRVSGK 675
Query: 708 DRCKSPTSAKMSRKLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESREAISALHFCETF 767
R + +S L P DV+ R S D + L+F +TF
Sbjct: 676 KRAANASSKLQEANAQLAEQACPH-DVEMTPV--QRRIEPRSADDSLSGVVRCLYFADTF 732
Query: 768 TRKTDSSPSPCLWVGTTLGTVLVIALNLPP---GGEQRLLQPV-IVSPSGTILRLKGAIL 823
R + P +W GT G+V AL +P GGE+R Q V V L + ++
Sbjct: 733 LR-DGAHHGPTMWAGTNSGSVFAYALEVPAAAVGGEKRPEQAVEAVLGKEVQLMHRAPVV 791
Query: 824 RMAFLDTTGCLIPPAYEPWREHNVPEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICS 883
+A LD G +P YE R+ + + ++ +I S
Sbjct: 792 AIAVLDGRGRPLPEPYEASRD----------------------LAQAPDMQGGHAVLIAS 829
Query: 884 EKQAKVISLPTQNCAYKQNIT--ETSFVLRGDIVALSN-------SICLACFCANGHIMT 934
E+Q KV +LP + K +T E V + + ++ CLAC G +
Sbjct: 830 EEQFKVFTLPKVSAKTKFKLTAHEGCRVRKVALATFASVACEDYAETCLACLTNLGDVHV 889
Query: 935 FSLPSLRPLLDVYYLPLTNMRIARTFCFTNNGQALYLVSPTEIQRLTYSQETCENLQEML 994
FS+P LRP + + ++ + FT +GQ YL+SP+E +R + S N+ E L
Sbjct: 890 FSVPGLRPQVHYSCIRKEDISGIASCVFTRHGQGFYLISPSEFERFSLS---ARNITEPL 946
Query: 995 GEL 997
L
Sbjct: 947 CSL 949
>gi|62739163 lethal giant larvae homolog 2 isoform b [Homo sapiens]
Length = 356
Score = 190 bits (483), Expect = 6e-48
Identities = 111/338 (32%), Positives = 179/338 (52%), Gaps = 31/338 (9%)
Query: 37 IQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHD 96
++E L+ + FQ KTV HGFP+QPSAL + P +ILA+GT++GA++L+G PGVE H
Sbjct: 12 VRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQ 71
Query: 97 SGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPA--ILHSLKFCRE----------R 144
AV Q+ L + LV+ L D++LHLW+L+ K A + F +
Sbjct: 72 ENNAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQ 131
Query: 145 VTFCHLPFQS-KWLYVGTERGNIHIVNVESF------TLSGYVIMWNKAIELSSKSHPGP 197
+T LP S + LY+GTE GN+ +V + +F T+S ++ E +
Sbjct: 132 ITVV-LPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEM 190
Query: 198 VVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAWHHEGKQFICSHS 257
V + ++P D ++LIG+ G VV+WDL+ + Y + + + ++ W +G+ + HS
Sbjct: 191 VEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHS 250
Query: 258 DGTLTIWNVRSPA---KPVQTITPHGKQLKDGKKPEPCKPILKVEFKTTRSGEPFIILSG 314
DG+ W V S A +P++++ P+G P PCK I ++ + TTR G PF I G
Sbjct: 251 DGSYCQWPVSSEAQQPEPLRSLVPYG--------PFPCKAITRILWLTTRQGLPFTIFQG 302
Query: 315 GLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCE 352
G+ + G R C++V+H + ++ F L E
Sbjct: 303 GMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTE 340
>gi|21426793 amisyn [Homo sapiens]
Length = 210
Score = 48.5 bits (114), Expect = 3e-05
Identities = 23/60 (38%), Positives = 39/60 (65%)
Query: 1049 GGIEGVKGAASGVVGELARARLALDERGQKLGDLEERTAAMLSSAESFSKHAHEIMLKYK 1108
GG + AA V + +A AL+ERG++LG EE+T + +SA+ F++ AH++ +K+K
Sbjct: 150 GGNSILHSAADSVTSAVQKASQALNERGERLGRAEEKTEDLKNSAQQFAETAHKLAMKHK 209
>gi|17402902 guanine nucleotide binding protein beta-subunit-like
polypeptide [Homo sapiens]
Length = 327
Score = 47.8 bits (112), Expect = 6e-05
Identities = 53/209 (25%), Positives = 91/209 (43%), Gaps = 23/209 (11%)
Query: 71 ILAVGTQTGALRLFG---RPGVECYCQHDSGAAVIQLQFLINEGALVSALADDTLHLWNL 127
+L G+Q+G + ++ R V H G V LQ L L+S D L LW+L
Sbjct: 39 LLFSGSQSGLVHIWSLQTRRAVTTLDGH-GGQCVTWLQTLPQGRQLLSQGRDLKLCLWDL 97
Query: 128 RQKRPAILHSLKFCRERVTFCHLPF----QSKWLYVGTERGNIHIVNVESFTLSGYVIMW 183
+ R A++ S+ C E V FC Q +W RG+ + +E + + +
Sbjct: 98 AEGRSAVVDSV--CLESVGFCRSSILAGGQPRWTLAVPGRGSDEVQILEMPSKTSVCALK 155
Query: 184 NKAIELSSKSHPGPVVHI-----SDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYT-YD 237
KA +K + + S P+ LL G+E G+VVLWD+ +K R ++
Sbjct: 156 PKA---DAKLGMPMCLRLWQADCSSRPL----LLAGYEDGSVVLWDVSEQKVCSRIACHE 208
Query: 238 EAIHSVAWHHEGKQFICSHSDGTLTIWNV 266
E + + + + + I + L +W++
Sbjct: 209 EPVMDLDFDSQKARGISGSAGKALAVWSL 237
>gi|16418439 WD repeat and FYVE domain containing 2 [Homo sapiens]
Length = 400
Score = 46.2 bits (108), Expect = 2e-04
Identities = 46/243 (18%), Positives = 97/243 (39%), Gaps = 40/243 (16%)
Query: 41 LQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLF-------GRPGVECYC 93
L+ + Q +V H P S ++F+P + L++G G + F V+ Y
Sbjct: 52 LKRDSGQYWPSVYHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQ 111
Query: 94 QHDSGAAVIQLQFLINEGALVSALADDTLHLWNLRQ--------KRPAILHSLKFCRERV 145
H S +I + E V + D W+ + + A+ L+F
Sbjct: 112 AHQSRVTMI---LFVLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASGLQF----- 163
Query: 146 TFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYVIMWNKAIELSSKSHPGPVVHISDNP 205
+++ +++G G + I+ +E N + + + H G V + +P
Sbjct: 164 -----DVETRHVFIGDHSGQVTILKLEQE---------NCTLVTTFRGHTGGVTALCWDP 209
Query: 206 MDEGKLLIGFESGTVVLWDLKSKK--ADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTI 263
+ L G +V++WD+ +K A +++ + ++++ +Q I DG + +
Sbjct: 210 VQR-VLFSGSSDHSVIMWDIGGRKGTAIELQGHNDRVQALSYAQHTRQLISCGGDGGIVV 268
Query: 264 WNV 266
WN+
Sbjct: 269 WNM 271
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 42.7 bits (99), Expect = 0.002
Identities = 40/211 (18%), Positives = 90/211 (42%), Gaps = 16/211 (7%)
Query: 57 PYQPSALAFDPVQKILAVGTQTGALRLFG-RPGVECYCQHDSGAAVIQLQFLINEGALVS 115
P LAF P + LA GT G + +FG G + Y G ++ + + + L S
Sbjct: 106 PVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLAS 165
Query: 116 ALADDTLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFT 175
D ++++++ + +LH+L+ + S+ L ++ G I I +V+
Sbjct: 166 GAIDGIINIFDIATGK--LLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHAN 223
Query: 176 LSGYVIMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYR-Y 234
L+G + H V++++ P D+ + +V +WD+ ++ + +
Sbjct: 224 LAG-----------TLSGHASWVLNVAFCP-DDTHFVSSSSDKSVKVWDVGTRTCVHTFF 271
Query: 235 TYDEAIHSVAWHHEGKQFICSHSDGTLTIWN 265
+ + + V ++ G + + D + I++
Sbjct: 272 DHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 41.6 bits (96), Expect = 0.004
Identities = 38/163 (23%), Positives = 76/163 (46%), Gaps = 16/163 (9%)
Query: 111 GALVSALADD-TLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHI- 168
G L+++ +DD TL +W+++Q+ +H L+ + + + KW G N +
Sbjct: 373 GMLLASCSDDMTLKIWSMKQE--VCIHDLQAHNKEI------YTIKWSPTGPATSNPNSN 424
Query: 169 VNVESFTLSGYVIMWNKAIELSSKS---HPGPVVHISDNPMDEGKLLI-GFESGTVVLWD 224
+ + S + V +W+ + + + H PV ++ +P +GK L G V +W+
Sbjct: 425 IMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP--DGKYLASGSFDKCVHIWN 482
Query: 225 LKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVR 267
+S + Y I V W+ G + S SDG++ + ++R
Sbjct: 483 TQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLR 525
Score = 36.2 bits (82), Expect = 0.18
Identities = 26/86 (30%), Positives = 37/86 (43%), Gaps = 4/86 (4%)
Query: 184 NKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYT-YDEAIHS 242
NK I S GP + NP L TV LWD++ + T + E ++S
Sbjct: 403 NKEIYTIKWSPTGPA---TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYS 459
Query: 243 VAWHHEGKQFICSHSDGTLTIWNVRS 268
VA+ +GK D + IWN +S
Sbjct: 460 VAFSPDGKYLASGSFDKCVHIWNTQS 485
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 41.6 bits (96), Expect = 0.004
Identities = 38/163 (23%), Positives = 76/163 (46%), Gaps = 16/163 (9%)
Query: 111 GALVSALADD-TLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHI- 168
G L+++ +DD TL +W+++Q+ +H L+ + + + KW G N +
Sbjct: 373 GMLLASCSDDMTLKIWSMKQE--VCIHDLQAHNKEI------YTIKWSPTGPATSNPNSN 424
Query: 169 VNVESFTLSGYVIMWNKAIELSSKS---HPGPVVHISDNPMDEGKLLI-GFESGTVVLWD 224
+ + S + V +W+ + + + H PV ++ +P +GK L G V +W+
Sbjct: 425 IMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP--DGKYLASGSFDKCVHIWN 482
Query: 225 LKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVR 267
+S + Y I V W+ G + S SDG++ + ++R
Sbjct: 483 TQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLR 525
Score = 36.2 bits (82), Expect = 0.18
Identities = 26/86 (30%), Positives = 37/86 (43%), Gaps = 4/86 (4%)
Query: 184 NKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYT-YDEAIHS 242
NK I S GP + NP L TV LWD++ + T + E ++S
Sbjct: 403 NKEIYTIKWSPTGPA---TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYS 459
Query: 243 VAWHHEGKQFICSHSDGTLTIWNVRS 268
VA+ +GK D + IWN +S
Sbjct: 460 VAFSPDGKYLASGSFDKCVHIWNTQS 485
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 41.6 bits (96), Expect = 0.004
Identities = 38/163 (23%), Positives = 76/163 (46%), Gaps = 16/163 (9%)
Query: 111 GALVSALADD-TLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHI- 168
G L+++ +DD TL +W+++Q+ +H L+ + + + KW G N +
Sbjct: 424 GMLLASCSDDMTLKIWSMKQE--VCIHDLQAHNKEI------YTIKWSPTGPATSNPNSN 475
Query: 169 VNVESFTLSGYVIMWNKAIELSSKS---HPGPVVHISDNPMDEGKLLI-GFESGTVVLWD 224
+ + S + V +W+ + + + H PV ++ +P +GK L G V +W+
Sbjct: 476 IMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP--DGKYLASGSFDKCVHIWN 533
Query: 225 LKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVR 267
+S + Y I V W+ G + S SDG++ + ++R
Sbjct: 534 TQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLR 576
Score = 36.2 bits (82), Expect = 0.18
Identities = 26/86 (30%), Positives = 37/86 (43%), Gaps = 4/86 (4%)
Query: 184 NKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYT-YDEAIHS 242
NK I S GP + NP L TV LWD++ + T + E ++S
Sbjct: 454 NKEIYTIKWSPTGPA---TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYS 510
Query: 243 VAWHHEGKQFICSHSDGTLTIWNVRS 268
VA+ +GK D + IWN +S
Sbjct: 511 VAFSPDGKYLASGSFDKCVHIWNTQS 536
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 41.6 bits (96), Expect = 0.004
Identities = 38/163 (23%), Positives = 76/163 (46%), Gaps = 16/163 (9%)
Query: 111 GALVSALADD-TLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHI- 168
G L+++ +DD TL +W+++Q+ +H L+ + + + KW G N +
Sbjct: 424 GMLLASCSDDMTLKIWSMKQE--VCIHDLQAHNKEI------YTIKWSPTGPATSNPNSN 475
Query: 169 VNVESFTLSGYVIMWNKAIELSSKS---HPGPVVHISDNPMDEGKLLI-GFESGTVVLWD 224
+ + S + V +W+ + + + H PV ++ +P +GK L G V +W+
Sbjct: 476 IMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP--DGKYLASGSFDKCVHIWN 533
Query: 225 LKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVR 267
+S + Y I V W+ G + S SDG++ + ++R
Sbjct: 534 TQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLR 576
Score = 36.2 bits (82), Expect = 0.18
Identities = 26/86 (30%), Positives = 37/86 (43%), Gaps = 4/86 (4%)
Query: 184 NKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYT-YDEAIHS 242
NK I S GP + NP L TV LWD++ + T + E ++S
Sbjct: 454 NKEIYTIKWSPTGPA---TSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYS 510
Query: 243 VAWHHEGKQFICSHSDGTLTIWNVRS 268
VA+ +GK D + IWN +S
Sbjct: 511 VAFSPDGKYLASGSFDKCVHIWNTQS 536
>gi|55769546 PAK1 interacting protein 1 [Homo sapiens]
Length = 392
Score = 40.4 bits (93), Expect = 0.009
Identities = 32/146 (21%), Positives = 64/146 (43%), Gaps = 15/146 (10%)
Query: 108 INEGALVSALADDTLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIH 167
+N +V+ D+T+H++++++K I H C + ++ L G E G I
Sbjct: 50 VNSRFVVTGSKDETIHIYDMKKK---IEHGALVHHSGTITCLKFYGNRHLISGAEDGLIC 106
Query: 168 IVNVESFTLSGYVIMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKS 227
I + + + S K+H G V +S +P + L +G + T+ W+L
Sbjct: 107 IWDAKKWECL-----------KSIKAHKGQVTFLSIHPSGKLALSVGTDK-TLRTWNLVE 154
Query: 228 KKADYRYTYDEAIHSVAWHHEGKQFI 253
++ + + H V W G+Q++
Sbjct: 155 GRSAFIKNIKQNAHIVEWSPRGEQYV 180
>gi|18482373 WD repeat and FYVE domain containing 1 [Homo sapiens]
Length = 410
Score = 40.0 bits (92), Expect = 0.012
Identities = 25/117 (21%), Positives = 53/117 (45%), Gaps = 12/117 (10%)
Query: 152 FQSKWLYVGTERGNIHIVNVESFTLSGYVIMWNKAIELSSKSHPGPVVHISDNPMDEGKL 211
F +++ +VG G I ++ +E T S + + K H G V + +P+ L
Sbjct: 165 FDTQYAFVGDYSGQITLLKLEQNTCS---------VITTLKGHEGSVACLWWDPIQR-LL 214
Query: 212 LIGFESGTVVLWDLKSKKADYRYT--YDEAIHSVAWHHEGKQFICSHSDGTLTIWNV 266
G ++++WD+ +K + + + S+ + +Q + SDG + +WN+
Sbjct: 215 FSGASDNSIIMWDIGGRKGRTLLLQGHHDKVQSLCYLQLTRQLVSCSSDGGIAVWNM 271
>gi|222080092 WD repeat domain 91 [Homo sapiens]
Length = 747
Score = 39.7 bits (91), Expect = 0.016
Identities = 58/284 (20%), Positives = 114/284 (40%), Gaps = 26/284 (9%)
Query: 7 RKVLDGLTAGSSSASQQQQQQ-HPPGNREPEIQETLQSEHFQLCKTVRHGFPYQPSA-LA 64
+ +L GL G S SQ +Q++ G E+ T S+ + K G +P L
Sbjct: 312 KSLLSGLATGESGWSQHRQRRLQDHGKERKELFSTTTSQCAEK-KPEASGPEAEPCPELH 370
Query: 65 FDPVQKIL---AVGTQTGALRL---FGRPGVECYCQHDSGAAVIQLQFLINEGALVSALA 118
+PV+ + + G + G +R F G E Y +H S +++ + + + S
Sbjct: 371 TEPVEPLTRASSAGPEGGGVRPEQPFIVLGQEEYGEHHS--SIMHCRVDCSGRRVASLDV 428
Query: 119 DDTLHLWNLR----------QKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHI 168
D + +W+ K P + R+R+ + LY + N+
Sbjct: 429 DGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLYDTEAKKNLCE 488
Query: 169 VNVESFT--LSGYVIMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLK 226
+N+ + N A + S + P + + D G + G ++LWD K
Sbjct: 489 ININDNMPRILSLACSPNGASFVCSAAAPSLTSQVDFSAPDIGSKGMNQVPGRLLLWDTK 548
Query: 227 SKKADYRYTYDE---AIHSVAWHHEGKQFICSHSDGTLTIWNVR 267
+ K +++ D AI+ A++H G + +DG + +++++
Sbjct: 549 TMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQ 592
>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
Length = 1298
Score = 39.7 bits (91), Expect = 0.016
Identities = 28/103 (27%), Positives = 45/103 (43%), Gaps = 4/103 (3%)
Query: 194 HPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKA-DYRYTYDEAIHSVAWHHEGKQF 252
H V H+ +P+ EG L G + GTV +WD + + + + W+ E
Sbjct: 541 HTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYL 600
Query: 253 ICSHS-DGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKP 294
+ S S D T+ +W+ R V T+ HG + G P +P
Sbjct: 601 LISGSWDYTIKVWDTRE-GTCVDTVYDHGADVY-GLTCHPSRP 641
Score = 32.3 bits (72), Expect = 2.6
Identities = 26/94 (27%), Positives = 37/94 (39%), Gaps = 3/94 (3%)
Query: 189 LSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDE-AIHSVAWHH 247
L H + P D L GT+ +WD+ + A Y +E I+S++W
Sbjct: 363 LRDLGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAP 422
Query: 248 EGKQFIC-SHSDGTLTIWNVRSPAKPVQTITPHG 280
G I S IWNV+ K +Q HG
Sbjct: 423 GGLNCIAGGTSRNGAFIWNVQK-GKIIQRFNEHG 455
>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
Length = 1322
Score = 39.7 bits (91), Expect = 0.016
Identities = 28/103 (27%), Positives = 45/103 (43%), Gaps = 4/103 (3%)
Query: 194 HPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKA-DYRYTYDEAIHSVAWHHEGKQF 252
H V H+ +P+ EG L G + GTV +WD + + + + W+ E
Sbjct: 565 HTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYL 624
Query: 253 ICSHS-DGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKP 294
+ S S D T+ +W+ R V T+ HG + G P +P
Sbjct: 625 LISGSWDYTIKVWDTRE-GTCVDTVYDHGADVY-GLTCHPSRP 665
Score = 32.3 bits (72), Expect = 2.6
Identities = 26/94 (27%), Positives = 37/94 (39%), Gaps = 3/94 (3%)
Query: 189 LSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDE-AIHSVAWHH 247
L H + P D L GT+ +WD+ + A Y +E I+S++W
Sbjct: 387 LRDLGHVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAP 446
Query: 248 EGKQFIC-SHSDGTLTIWNVRSPAKPVQTITPHG 280
G I S IWNV+ K +Q HG
Sbjct: 447 GGLNCIAGGTSRNGAFIWNVQK-GKIIQRFNEHG 479
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 39.7 bits (91), Expect = 0.016
Identities = 38/159 (23%), Positives = 73/159 (45%), Gaps = 16/159 (10%)
Query: 111 GALVSALADD-TLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHI- 168
G L+++ +DD TL +W+++Q A +H L+ + + + KW G N +
Sbjct: 371 GMLLASCSDDMTLKIWSMKQD--ACVHDLQAHSKEI------YTIKWSPTGPATSNPNSS 422
Query: 169 VNVESFTLSGYVIMWNKAIELSSKS---HPGPVVHISDNPMDEGKLLI-GFESGTVVLWD 224
+ + S + V +W+ + + + H PV ++ +P +GK L G V +W+
Sbjct: 423 IMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSP--DGKYLASGSFDKYVHIWN 480
Query: 225 LKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTI 263
+S + Y I V W+ G + S SDG++ +
Sbjct: 481 TQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCV 519
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 39.7 bits (91), Expect = 0.016
Identities = 38/159 (23%), Positives = 73/159 (45%), Gaps = 16/159 (10%)
Query: 111 GALVSALADD-TLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHI- 168
G L+++ +DD TL +W+++Q A +H L+ + + + KW G N +
Sbjct: 371 GMLLASCSDDMTLKIWSMKQD--ACVHDLQAHSKEI------YTIKWSPTGPATSNPNSS 422
Query: 169 VNVESFTLSGYVIMWNKAIELSSKS---HPGPVVHISDNPMDEGKLLI-GFESGTVVLWD 224
+ + S + V +W+ + + + H PV ++ +P +GK L G V +W+
Sbjct: 423 IMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSP--DGKYLASGSFDKYVHIWN 480
Query: 225 LKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTI 263
+S + Y I V W+ G + S SDG++ +
Sbjct: 481 TQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCV 519
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 39.7 bits (91), Expect = 0.016
Identities = 38/159 (23%), Positives = 73/159 (45%), Gaps = 16/159 (10%)
Query: 111 GALVSALADD-TLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHI- 168
G L+++ +DD TL +W+++Q A +H L+ + + + KW G N +
Sbjct: 371 GMLLASCSDDMTLKIWSMKQD--ACVHDLQAHSKEI------YTIKWSPTGPATSNPNSS 422
Query: 169 VNVESFTLSGYVIMWNKAIELSSKS---HPGPVVHISDNPMDEGKLLI-GFESGTVVLWD 224
+ + S + V +W+ + + + H PV ++ +P +GK L G V +W+
Sbjct: 423 IMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSP--DGKYLASGSFDKYVHIWN 480
Query: 225 LKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTI 263
+S + Y I V W+ G + S SDG++ +
Sbjct: 481 TQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCV 519
>gi|225543215 antigen identified by monoclonal antibody Ki-67 isoform
2 [Homo sapiens]
Length = 2896
Score = 39.3 bits (90), Expect = 0.021
Identities = 28/102 (27%), Positives = 46/102 (45%), Gaps = 5/102 (4%)
Query: 676 DPYRREPRSPRKSRQPSGAGLCDISEGTVVPEDRCKSPTSAKMSRKLSLPTDLKPDLDVK 735
+P RR PR+P++ QP L D++ T + E + S + +P + P L+V
Sbjct: 2300 EPSRRRPRAPKEKAQP----LEDLAGFTELSETSGHTQESLTAGKATKIPCE-SPPLEVV 2354
Query: 736 DNSFSRSRSSSVTSIDKESREAISALHFCETFTRKTDSSPSP 777
D + S R + +E SA+ F +T TD+ P
Sbjct: 2355 DTTASTKRHLRTRVQKVQVKEEPSAVKFTQTSGETTDADKEP 2396
>gi|103472005 antigen identified by monoclonal antibody Ki-67 isoform
1 [Homo sapiens]
Length = 3256
Score = 39.3 bits (90), Expect = 0.021
Identities = 28/102 (27%), Positives = 46/102 (45%), Gaps = 5/102 (4%)
Query: 676 DPYRREPRSPRKSRQPSGAGLCDISEGTVVPEDRCKSPTSAKMSRKLSLPTDLKPDLDVK 735
+P RR PR+P++ QP L D++ T + E + S + +P + P L+V
Sbjct: 2660 EPSRRRPRAPKEKAQP----LEDLAGFTELSETSGHTQESLTAGKATKIPCE-SPPLEVV 2714
Query: 736 DNSFSRSRSSSVTSIDKESREAISALHFCETFTRKTDSSPSP 777
D + S R + +E SA+ F +T TD+ P
Sbjct: 2715 DTTASTKRHLRTRVQKVQVKEEPSAVKFTQTSGETTDADKEP 2756
>gi|189571685 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 39.3 bits (90), Expect = 0.021
Identities = 43/158 (27%), Positives = 64/158 (40%), Gaps = 20/158 (12%)
Query: 113 LVSALADDTLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVE 172
L + D T+ L++LR LKF V C + G+I +
Sbjct: 25 LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCF----------SPSGHI----LA 70
Query: 173 SFTLSGYVIMWN--KAIELSSKSHP-GPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKK 229
S + G ++WN L+ P G V + D L G GTVVLW+ +S K
Sbjct: 71 SCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYK 130
Query: 230 ADYR--YTYDEAIHSVAWHHEGKQFICSHSDGTLTIWN 265
YR D ++ + A+ G F+ S G LT+W+
Sbjct: 131 L-YRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD 167
>gi|189571683 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 39.3 bits (90), Expect = 0.021
Identities = 43/158 (27%), Positives = 64/158 (40%), Gaps = 20/158 (12%)
Query: 113 LVSALADDTLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVE 172
L + D T+ L++LR LKF V C + G+I +
Sbjct: 25 LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCF----------SPSGHI----LA 70
Query: 173 SFTLSGYVIMWN--KAIELSSKSHP-GPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKK 229
S + G ++WN L+ P G V + D L G GTVVLW+ +S K
Sbjct: 71 SCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYK 130
Query: 230 ADYR--YTYDEAIHSVAWHHEGKQFICSHSDGTLTIWN 265
YR D ++ + A+ G F+ S G LT+W+
Sbjct: 131 L-YRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD 167
>gi|189571681 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 39.3 bits (90), Expect = 0.021
Identities = 43/158 (27%), Positives = 64/158 (40%), Gaps = 20/158 (12%)
Query: 113 LVSALADDTLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVE 172
L + D T+ L++LR LKF V C + G+I +
Sbjct: 25 LATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCF----------SPSGHI----LA 70
Query: 173 SFTLSGYVIMWN--KAIELSSKSHP-GPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKK 229
S + G ++WN L+ P G V + D L G GTVVLW+ +S K
Sbjct: 71 SCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYK 130
Query: 230 ADYR--YTYDEAIHSVAWHHEGKQFICSHSDGTLTIWN 265
YR D ++ + A+ G F+ S G LT+W+
Sbjct: 131 L-YRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD 167
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 38.9 bits (89), Expect = 0.027
Identities = 35/158 (22%), Positives = 71/158 (44%), Gaps = 16/158 (10%)
Query: 111 GALVSALADDT-LHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIV 169
G L++ DD ++LW++ +P + SL V L + + G++ G+I +
Sbjct: 33 GRLLATGGDDCRVNLWSIN--KPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVW 90
Query: 170 NVESFTLSGYVIMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKK 229
++E+ + +M +KA S HP S G + + LWD++ K
Sbjct: 91 DLEAAKILR-TLMGHKANICSLDFHPYGEFVAS-----------GSQDTNIKLWDIRRKG 138
Query: 230 ADYRYT-YDEAIHSVAWHHEGKQFICSHSDGTLTIWNV 266
+RY + +A+ + + +GK + D T+ +W++
Sbjct: 139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDL 176
Score = 33.1 bits (74), Expect = 1.5
Identities = 21/80 (26%), Positives = 40/80 (50%), Gaps = 2/80 (2%)
Query: 189 LSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEA-IHSVAWHH 247
+S H PV + N +E ++ G +SG++ +WDL++ K +A I S+ +H
Sbjct: 57 MSLTGHTSPVESVRLNTPEE-LIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHP 115
Query: 248 EGKQFICSHSDGTLTIWNVR 267
G+ D + +W++R
Sbjct: 116 YGEFVASGSQDTNIKLWDIR 135
>gi|14149987 WD repeat domain 24 [Homo sapiens]
Length = 790
Score = 38.9 bits (89), Expect = 0.027
Identities = 28/112 (25%), Positives = 46/112 (41%), Gaps = 9/112 (8%)
Query: 177 SGYVIMWN----KAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADY 232
+G V +W+ E +H GPV +P D G L G V +WD+ + +A
Sbjct: 185 NGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKE 244
Query: 233 RYTYD--EAIHSVAWHHEGKQFICSHS---DGTLTIWNVRSPAKPVQTITPH 279
+ ++ V W E + + + S D + +W+VR P P H
Sbjct: 245 MHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEH 296
Score = 32.7 bits (73), Expect = 2.0
Identities = 27/116 (23%), Positives = 51/116 (43%), Gaps = 18/116 (15%)
Query: 243 VAWHHEGKQFICSHS-DGTLTIWNVRSPAKPVQTITPHGKQLKDGKKPEPCKPILKVEFK 301
V WH + + + + +G + WN+ P++ Q D E + + KV F
Sbjct: 80 VVWHQMDENLLATAATNGVVVTWNLGRPSRNKQ----------DQLFTEHKRTVNKVCFH 129
Query: 302 TTRSGEPFIILSGG----LSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCET 353
T E ++LSG + + R+ ++ G+S +V ++ +SI D+ T T
Sbjct: 130 PT---EAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFAST 182
Score = 32.7 bits (73), Expect = 2.0
Identities = 24/111 (21%), Positives = 49/111 (44%), Gaps = 8/111 (7%)
Query: 177 SGYVIMWNKAIELSSKS------HPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKA 230
+G V+ WN +K H V + +P + LL G + G + +DL+ K +
Sbjct: 96 NGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDS 155
Query: 231 DYRYT-YDEAIHSVAWH-HEGKQFICSHSDGTLTIWNVRSPAKPVQTITPH 279
++ E++ V + + F + +G + +W++R P + + T H
Sbjct: 156 VSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAH 206
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,438,841
Number of Sequences: 37866
Number of extensions: 2417015
Number of successful extensions: 13450
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 175
Number of HSP's that attempted gapping in prelim test: 12596
Number of HSP's gapped (non-prelim): 918
length of query: 1115
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1002
effective length of database: 13,968,660
effective search space: 13996597320
effective search space used: 13996597320
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.