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Search of human proteins with 188497754
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|188497754 hexokinase 1 isoform HKI [Homo sapiens]
(917 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|188497754 hexokinase 1 isoform HKI [Homo sapiens] 1828 0.0
gi|15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens] 1788 0.0
gi|15991831 hexokinase 1 isoform HKI-ta/tb [Homo sapiens] 1788 0.0
gi|188497750 hexokinase 1 isoform HKI-td [Homo sapiens] 1788 0.0
gi|15991827 hexokinase 1 isoform HKI-R [Homo sapiens] 1788 0.0
gi|15553127 hexokinase 2 [Homo sapiens] 1398 0.0
gi|156151420 hexokinase domain containing 1 [Homo sapiens] 1351 0.0
gi|194097330 hexokinase 3 [Homo sapiens] 945 0.0
gi|15967161 glucokinase isoform 3 [Homo sapiens] 506 e-143
gi|4503951 glucokinase isoform 1 [Homo sapiens] 504 e-142
gi|15967159 glucokinase isoform 2 [Homo sapiens] 503 e-142
gi|164663810 ribosomal modification protein rimK-like family mem... 35 0.42
gi|134254462 ribosomal modification protein rimK-like family mem... 33 0.93
gi|21389509 KPL2 protein isoform 2 [Homo sapiens] 32 2.7
gi|145699133 KPL2 protein isoform 1 [Homo sapiens] 32 2.7
gi|42415492 chromosome 14 open reading frame 106 [Homo sapiens] 30 7.9
>gi|188497754 hexokinase 1 isoform HKI [Homo sapiens]
Length = 917
Score = 1828 bits (4735), Expect = 0.0
Identities = 917/917 (100%), Positives = 917/917 (100%)
Query: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 60
MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT
Sbjct: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 60
Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120
VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH
Sbjct: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120
Query: 121 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 180
GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV
Sbjct: 121 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 180
Query: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 240
EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME
Sbjct: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 240
Query: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 300
ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM
Sbjct: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 300
Query: 301 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 360
YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG
Sbjct: 301 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 360
Query: 361 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH 420
VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH
Sbjct: 361 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH 420
Query: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 480
PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT
Sbjct: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 480
Query: 481 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 540
KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV
Sbjct: 481 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 540
Query: 541 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 600
LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF
Sbjct: 541 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 600
Query: 601 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 660
TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG
Sbjct: 601 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 660
Query: 661 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 720
TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD
Sbjct: 661 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 720
Query: 721 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 780
IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG
Sbjct: 721 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 780
Query: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 840
IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA
Sbjct: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 840
Query: 841 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 900
VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG
Sbjct: 841 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 900
Query: 901 AALITAVGVRLRTEASS 917
AALITAVGVRLRTEASS
Sbjct: 901 AALITAVGVRLRTEASS 917
>gi|15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
Length = 921
Score = 1788 bits (4632), Expect = 0.0
Identities = 896/897 (99%), Positives = 897/897 (100%)
Query: 21 KIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 80
+IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF
Sbjct: 25 EIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 84
Query: 81 IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 140
IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK
Sbjct: 85 IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 144
Query: 141 RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD 200
RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD
Sbjct: 145 RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD 204
Query: 201 ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE 260
ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE
Sbjct: 205 ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE 264
Query: 261 WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF 320
WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF
Sbjct: 265 WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF 324
Query: 321 EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF 380
EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF
Sbjct: 325 EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF 384
Query: 381 RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV 440
RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV
Sbjct: 385 RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV 444
Query: 441 RFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR 500
RFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR
Sbjct: 445 RFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR 504
Query: 501 KQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIY 560
KQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIY
Sbjct: 505 KQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIY 564
Query: 561 AIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWT 620
AIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWT
Sbjct: 565 AIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWT 624
Query: 621 KGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGT 680
KGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGT
Sbjct: 625 KGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGT 684
Query: 681 GSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQR 740
GSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQR
Sbjct: 685 GSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQR 744
Query: 741 YEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQV 800
YEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQV
Sbjct: 745 YEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQV 804
Query: 801 RAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGV 860
RAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGV
Sbjct: 805 RAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGV 864
Query: 861 DGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 917
DGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS
Sbjct: 865 DGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 921
Score = 495 bits (1275), Expect = e-140
Identities = 235/447 (52%), Positives = 328/447 (73%)
Query: 17 DQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76
+Q ++I++ L L+ + L+++ R R EM+ GL + + A VKMLP+FVR PDG+E
Sbjct: 469 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 528
Query: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGD 136
GDF+ALDLGG++FR+L V++ K + V M +++Y P I+ G+G +LFDH+ C+ D
Sbjct: 529 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 588
Query: 137 FMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKR 196
F++ IK ++P+GFTFSFPCQQ+ +D ILITWTK FKA+ G DVV LL AIK+R
Sbjct: 589 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 648
Query: 197 GDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256
++D ++VAVVNDTVGTMMTC Y++ CEVGLI+GTG+NACYMEE++++++VEGD+G+MC
Sbjct: 649 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 708
Query: 257 INTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKE 316
IN EWGAFGD+G L+DIRT +DR +D SLN GKQ +EKM+SGMYLGE+VR IL+ K+
Sbjct: 709 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 768
Query: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCT 376
G LF G+I+ L TRG F T +S IE ++ L + IL +LG+ + DD + V+ VC
Sbjct: 769 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 828
Query: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVP 436
+VS R+A L A + A+++++R+N+G RL TVGVDG+LYK HP +SR H+T++ L P
Sbjct: 829 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 888
Query: 437 DSDVRFLLSESGSGKGAAMVTAVAYRL 463
+V FLLSE GSGKGAA++TAV RL
Sbjct: 889 KCNVSFLLSEDGSGKGAALITAVGVRL 915
>gi|15991831 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
Length = 921
Score = 1788 bits (4632), Expect = 0.0
Identities = 896/897 (99%), Positives = 897/897 (100%)
Query: 21 KIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 80
+IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF
Sbjct: 25 EIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 84
Query: 81 IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 140
IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK
Sbjct: 85 IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 144
Query: 141 RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD 200
RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD
Sbjct: 145 RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD 204
Query: 201 ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE 260
ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE
Sbjct: 205 ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE 264
Query: 261 WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF 320
WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF
Sbjct: 265 WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF 324
Query: 321 EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF 380
EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF
Sbjct: 325 EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF 384
Query: 381 RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV 440
RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV
Sbjct: 385 RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV 444
Query: 441 RFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR 500
RFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR
Sbjct: 445 RFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR 504
Query: 501 KQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIY 560
KQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIY
Sbjct: 505 KQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIY 564
Query: 561 AIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWT 620
AIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWT
Sbjct: 565 AIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWT 624
Query: 621 KGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGT 680
KGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGT
Sbjct: 625 KGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGT 684
Query: 681 GSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQR 740
GSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQR
Sbjct: 685 GSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQR 744
Query: 741 YEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQV 800
YEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQV
Sbjct: 745 YEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQV 804
Query: 801 RAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGV 860
RAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGV
Sbjct: 805 RAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGV 864
Query: 861 DGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 917
DGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS
Sbjct: 865 DGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 921
Score = 495 bits (1275), Expect = e-140
Identities = 235/447 (52%), Positives = 328/447 (73%)
Query: 17 DQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76
+Q ++I++ L L+ + L+++ R R EM+ GL + + A VKMLP+FVR PDG+E
Sbjct: 469 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 528
Query: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGD 136
GDF+ALDLGG++FR+L V++ K + V M +++Y P I+ G+G +LFDH+ C+ D
Sbjct: 529 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 588
Query: 137 FMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKR 196
F++ IK ++P+GFTFSFPCQQ+ +D ILITWTK FKA+ G DVV LL AIK+R
Sbjct: 589 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 648
Query: 197 GDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256
++D ++VAVVNDTVGTMMTC Y++ CEVGLI+GTG+NACYMEE++++++VEGD+G+MC
Sbjct: 649 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 708
Query: 257 INTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKE 316
IN EWGAFGD+G L+DIRT +DR +D SLN GKQ +EKM+SGMYLGE+VR IL+ K+
Sbjct: 709 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 768
Query: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCT 376
G LF G+I+ L TRG F T +S IE ++ L + IL +LG+ + DD + V+ VC
Sbjct: 769 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 828
Query: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVP 436
+VS R+A L A + A+++++R+N+G RL TVGVDG+LYK HP +SR H+T++ L P
Sbjct: 829 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 888
Query: 437 DSDVRFLLSESGSGKGAAMVTAVAYRL 463
+V FLLSE GSGKGAA++TAV RL
Sbjct: 889 KCNVSFLLSEDGSGKGAALITAVGVRL 915
>gi|188497750 hexokinase 1 isoform HKI-td [Homo sapiens]
Length = 905
Score = 1788 bits (4631), Expect = 0.0
Identities = 896/896 (100%), Positives = 896/896 (100%)
Query: 22 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 81
IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI
Sbjct: 10 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 69
Query: 82 ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 141
ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR
Sbjct: 70 ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 129
Query: 142 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 201
KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA
Sbjct: 130 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 189
Query: 202 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 261
NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW
Sbjct: 190 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 249
Query: 262 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 321
GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE
Sbjct: 250 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 309
Query: 322 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 381
GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR
Sbjct: 310 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 369
Query: 382 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 441
SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR
Sbjct: 370 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 429
Query: 442 FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK 501
FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK
Sbjct: 430 FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK 489
Query: 502 QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA 561
QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA
Sbjct: 490 QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA 549
Query: 562 IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK 621
IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK
Sbjct: 550 IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK 609
Query: 622 GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG 681
GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG
Sbjct: 610 GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG 669
Query: 682 SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY 741
SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY
Sbjct: 670 SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY 729
Query: 742 EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR 801
EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR
Sbjct: 730 EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR 789
Query: 802 AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 861
AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD
Sbjct: 790 AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 849
Query: 862 GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 917
GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS
Sbjct: 850 GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 905
Score = 495 bits (1275), Expect = e-140
Identities = 235/447 (52%), Positives = 328/447 (73%)
Query: 17 DQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76
+Q ++I++ L L+ + L+++ R R EM+ GL + + A VKMLP+FVR PDG+E
Sbjct: 453 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 512
Query: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGD 136
GDF+ALDLGG++FR+L V++ K + V M +++Y P I+ G+G +LFDH+ C+ D
Sbjct: 513 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 572
Query: 137 FMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKR 196
F++ IK ++P+GFTFSFPCQQ+ +D ILITWTK FKA+ G DVV LL AIK+R
Sbjct: 573 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 632
Query: 197 GDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256
++D ++VAVVNDTVGTMMTC Y++ CEVGLI+GTG+NACYMEE++++++VEGD+G+MC
Sbjct: 633 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 692
Query: 257 INTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKE 316
IN EWGAFGD+G L+DIRT +DR +D SLN GKQ +EKM+SGMYLGE+VR IL+ K+
Sbjct: 693 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 752
Query: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCT 376
G LF G+I+ L TRG F T +S IE ++ L + IL +LG+ + DD + V+ VC
Sbjct: 753 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 812
Query: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVP 436
+VS R+A L A + A+++++R+N+G RL TVGVDG+LYK HP +SR H+T++ L P
Sbjct: 813 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 872
Query: 437 DSDVRFLLSESGSGKGAAMVTAVAYRL 463
+V FLLSE GSGKGAA++TAV RL
Sbjct: 873 KCNVSFLLSEDGSGKGAALITAVGVRL 899
Score = 494 bits (1271), Expect = e-139
Identities = 235/445 (52%), Positives = 325/445 (73%)
Query: 467 HRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENG 526
H I++ L L+ + L+++ R R EM+ GL + + A VKMLP+FVR PDG+E G
Sbjct: 7 HDFIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG 66
Query: 527 DFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFL 586
DF+ALDLGG++FR+L V++ K + V M +++Y P I+ G+G +LFDH+ C+ DF+
Sbjct: 67 DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM 126
Query: 587 DYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREE 646
+ IK ++P+GFTFSFPCQQ+ +D ILITWTK FKA+ G DVV LL AIK+R +
Sbjct: 127 EKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGD 186
Query: 647 FDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCIN 706
+D ++VAVVNDTVGTMMTC Y++ CEVGLI+GTG+NACYMEE++++++VEGD+G+MCIN
Sbjct: 187 YDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN 246
Query: 707 MEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGF 766
EWGAFGD+G L+DIRT +DR +D SLN GKQ +EKM+SGMYLGE+VR IL+ K+G
Sbjct: 247 TEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGL 306
Query: 767 LFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVV 826
LF G+I+ L TRG F T +S IE ++ L + IL +LG+ + DD + V+ VC +V
Sbjct: 307 LFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIV 366
Query: 827 SRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKC 886
S R+A L A + A+++++R+N+G RL TVGVDG+LYK HP +SR H+T++ L P
Sbjct: 367 SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDS 426
Query: 887 NVSFLLSEDGSGKGAALITAVGVRL 911
+V FLLSE GSGKGAA++TAV RL
Sbjct: 427 DVRFLLSESGSGKGAAMVTAVAYRL 451
>gi|15991827 hexokinase 1 isoform HKI-R [Homo sapiens]
Length = 916
Score = 1788 bits (4631), Expect = 0.0
Identities = 896/896 (100%), Positives = 896/896 (100%)
Query: 22 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 81
IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI
Sbjct: 21 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80
Query: 82 ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 141
ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR
Sbjct: 81 ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 140
Query: 142 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 201
KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA
Sbjct: 141 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 200
Query: 202 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 261
NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW
Sbjct: 201 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 260
Query: 262 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 321
GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE
Sbjct: 261 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 320
Query: 322 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 381
GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR
Sbjct: 321 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 380
Query: 382 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 441
SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR
Sbjct: 381 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 440
Query: 442 FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK 501
FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK
Sbjct: 441 FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK 500
Query: 502 QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA 561
QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA
Sbjct: 501 QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA 560
Query: 562 IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK 621
IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK
Sbjct: 561 IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK 620
Query: 622 GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG 681
GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG
Sbjct: 621 GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG 680
Query: 682 SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY 741
SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY
Sbjct: 681 SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY 740
Query: 742 EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR 801
EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR
Sbjct: 741 EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR 800
Query: 802 AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 861
AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD
Sbjct: 801 AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 860
Query: 862 GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 917
GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS
Sbjct: 861 GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 916
Score = 495 bits (1275), Expect = e-140
Identities = 235/447 (52%), Positives = 328/447 (73%)
Query: 17 DQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76
+Q ++I++ L L+ + L+++ R R EM+ GL + + A VKMLP+FVR PDG+E
Sbjct: 464 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 523
Query: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGD 136
GDF+ALDLGG++FR+L V++ K + V M +++Y P I+ G+G +LFDH+ C+ D
Sbjct: 524 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 583
Query: 137 FMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKR 196
F++ IK ++P+GFTFSFPCQQ+ +D ILITWTK FKA+ G DVV LL AIK+R
Sbjct: 584 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 643
Query: 197 GDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256
++D ++VAVVNDTVGTMMTC Y++ CEVGLI+GTG+NACYMEE++++++VEGD+G+MC
Sbjct: 644 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 703
Query: 257 INTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKE 316
IN EWGAFGD+G L+DIRT +DR +D SLN GKQ +EKM+SGMYLGE+VR IL+ K+
Sbjct: 704 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 763
Query: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCT 376
G LF G+I+ L TRG F T +S IE ++ L + IL +LG+ + DD + V+ VC
Sbjct: 764 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 823
Query: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVP 436
+VS R+A L A + A+++++R+N+G RL TVGVDG+LYK HP +SR H+T++ L P
Sbjct: 824 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 883
Query: 437 DSDVRFLLSESGSGKGAAMVTAVAYRL 463
+V FLLSE GSGKGAA++TAV RL
Sbjct: 884 KCNVSFLLSEDGSGKGAALITAVGVRL 910
>gi|15553127 hexokinase 2 [Homo sapiens]
Length = 917
Score = 1398 bits (3618), Expect = 0.0
Identities = 673/912 (73%), Positives = 793/912 (86%)
Query: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 60
MIA+ LLAY+FTEL DQV+K+D+YLY MRLSDETL++I RFRKEM+ GL +PTA
Sbjct: 1 MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA 60
Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120
VKMLPTFVRS PDG+E G+F+ALDLGG++FR+L V+V Q V ME+++Y PE+I+
Sbjct: 61 VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR 120
Query: 121 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 180
GSG+QLFDH+AECL +FM+K +IKDKKLP+GFTFSFPC Q+K+DE+ L++WTK FK+SGV
Sbjct: 121 GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV 180
Query: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 240
EG DVV L+ KAI++RGD+D +IVAVVNDTVGTMMTCGYDD +CE+GLI+GTG+NACYME
Sbjct: 181 EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYME 240
Query: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 300
E+RHID+VEGDEGRMCIN EWGAFGDDGSL DIRTEFD+EID GSLNPGKQLFEKM+SGM
Sbjct: 241 EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM 300
Query: 301 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 360
Y+GELVRLILVKMAKE LLF G+++PELL G+F T D+S IE K+G+ A+E+L RLG
Sbjct: 301 YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG 360
Query: 361 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH 420
++P+ +DCV+ +C IVS RSA+L AATL A+L R+++NKG RLR+T+GVDGS+YK H
Sbjct: 361 LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH 420
Query: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 480
P +++R HKT+RRLVP DVRFL SE GSGKGAAMVTAVAYRLA+QHR ++TL H L+
Sbjct: 421 PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS 480
Query: 481 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 540
D LLEVK+RM+ EME GL K+TH +A VKMLP++V TPDGTE GDFLALDLGGTNFRV
Sbjct: 481 HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV 540
Query: 541 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 600
LLV++R+GK VEMHNKIYAIP E+M GTG+ELFDHIV CI+DFL+YMG+KG +PLGF
Sbjct: 541 LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF 600
Query: 601 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 660
TFSFPCQQ SLD IL+ WTKGFKA+ C G DVVTLL++AI RREEFDLDVVAVVNDTVG
Sbjct: 601 TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG 660
Query: 661 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 720
TMMTC +E+P CEVGLIVGTGSNACYMEEM+NVE+VEG++G+MC+NMEWGAFGDNGCLDD
Sbjct: 661 TMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 720
Query: 721 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 780
RT +D VDE SLN GKQR+EKMISGMYLGEIVRNILIDFTK+G LFRG+ISE LKTRG
Sbjct: 721 FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG 780
Query: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 840
IFETKFLSQIESD LALLQVRAILQ LGL STCDDSI+VK VC VV+RRAAQLCGAGMAA
Sbjct: 781 IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA 840
Query: 841 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 900
VVD+IRENRGLD L VTVGVDGTLYKLHPHF+++MH+TVK+L+PKC+VSFL SEDGSGKG
Sbjct: 841 VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG 900
Query: 901 AALITAVGVRLR 912
AALITAV R+R
Sbjct: 901 AALITAVACRIR 912
Score = 523 bits (1348), Expect = e-148
Identities = 248/449 (55%), Positives = 339/449 (75%)
Query: 17 DQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76
DQ + K L ++LS + L+++ R + EM+ GLS++ + +A VKMLPT+V + PDG+E
Sbjct: 465 DQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTE 524
Query: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGD 136
KGDF+ALDLGG++FR+L V+V + K V M +++Y P+ ++HG+G +LFDH+ +C+ D
Sbjct: 525 KGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIAD 584
Query: 137 FMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKR 196
F+E +K LP+GFTFSFPCQQ+ +DE+IL+ WTK FKASG EG DVV LL +AI +R
Sbjct: 585 FLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRR 644
Query: 197 GDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256
++D ++VAVVNDTVGTMMTCG++D HCEVGLI+GTG+NACYMEE+R+++LVEG+EGRMC
Sbjct: 645 EEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMC 704
Query: 257 INTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKE 316
+N EWGAFGD+G L+D RTEFD +D SLNPGKQ FEKM+SGMYLGE+VR IL+ K
Sbjct: 705 VNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKR 764
Query: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCT 376
GLLF GRI+ L TRG F T +S IE + L + IL LG+E + DD + V+ VCT
Sbjct: 765 GLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCT 824
Query: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVP 436
+V+ R+A L A + A+++R+R+N+G L+ TVGVDG+LYK HP +++ H+T++ L P
Sbjct: 825 VVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAP 884
Query: 437 DSDVRFLLSESGSGKGAAMVTAVAYRLAE 465
DV FL SE GSGKGAA++TAVA R+ E
Sbjct: 885 KCDVSFLQSEDGSGKGAALITAVACRIRE 913
>gi|156151420 hexokinase domain containing 1 [Homo sapiens]
Length = 917
Score = 1351 bits (3496), Expect = 0.0
Identities = 651/912 (71%), Positives = 782/912 (85%), Gaps = 1/912 (0%)
Query: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 60
M A L+A+YF++LK+DQ+KK+D++LY MRLSD+TL+DIM RFR EM+ GL++D NPTA
Sbjct: 1 MFAVHLMAFYFSKLKEDQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAA 60
Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120
VKMLPTFVR+IPDGSE G+F++LDLGGS FR+L+VQV E ++V MES+ Y TP I+
Sbjct: 61 VKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIR 120
Query: 121 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 180
G+G++LF++VA+CL DFM+ + +K KKLP+G TFSFPC+Q+K++E +L++WTK+FKA GV
Sbjct: 121 GNGTELFEYVADCLADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGV 180
Query: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 240
+ DVV L KA+++ D D +I+A+VNDTVGTMMTC YDD +CEVG+IIGTGTNACYME
Sbjct: 181 QDTDVVSRLTKAMRRHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYME 240
Query: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 300
++ +IDLVEGDEGRMCINTEWGAFGDDG+LEDIRTEFDRE+D GSLNPGKQLFEKM+SG+
Sbjct: 241 DMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGL 300
Query: 301 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 360
YLGELVRLIL+KMAK GLLF G + L T+GK T V+A+EK KEGL N +EIL LG
Sbjct: 301 YLGELVRLILLKMAKAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLG 360
Query: 361 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH 420
+EPS+ DC++VQHVCTIVSFRSANL AA L AIL RLR+NK RLRTTVG+DG+LYK H
Sbjct: 361 LEPSEADCIAVQHVCTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIH 420
Query: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 480
PQY +R HK +R+LVP DVRFLLSESGS KGAAMVTAVA R+ Q +QI+ LA F LT
Sbjct: 421 PQYPKRLHKVVRKLVPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLT 480
Query: 481 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 540
++ L++V+ +MRAE+E GL+K++H A V+MLP++V PDGTE G FLALDLGGTNFRV
Sbjct: 481 REQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRV 540
Query: 541 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 600
LLVKIRSG +R+V M+NKI+AIP+EIMQGTGEELFDHIV CI+DFLDYMG+KG +PLGF
Sbjct: 541 LLVKIRSG-RRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGF 599
Query: 601 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 660
TFSFPC+Q S+D G LI WTKGFKATDC G DVV +LR+AIKRR EFDLD+VAVVNDTVG
Sbjct: 600 TFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVG 659
Query: 661 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 720
TMMTC YE+P CE+GLI GTGSN CYME+M+N+EMVEG +G+MCIN EWG FGDNGC+DD
Sbjct: 660 TMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDD 719
Query: 721 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 780
IRT YD VDE SLN GKQRYEKM SGMYLGEIVR ILID TK+G LFRGQISE L+TRG
Sbjct: 720 IRTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRG 779
Query: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 840
IFETKFLSQIESDRLALLQVR ILQQLGL+STC+DSI+VK VCG VSRRAAQLCGAG+AA
Sbjct: 780 IFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAA 839
Query: 841 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 900
+V+K RE++GL+ L +TVGVDGTLYKLHPHFSRI+ +TVKEL+P+C+V+F+LSEDGSGKG
Sbjct: 840 IVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKG 899
Query: 901 AALITAVGVRLR 912
AALITAV RL+
Sbjct: 900 AALITAVAKRLQ 911
Score = 498 bits (1282), Expect = e-140
Identities = 235/450 (52%), Positives = 332/450 (73%)
Query: 465 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 524
+Q ++++ L H L+ D LL++ +R RAEME GL K T+ A VKMLP+FVR PDG+E
Sbjct: 17 DQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSE 76
Query: 525 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 584
NG+FL+LDLGG+ FRVL V++ KR V+M ++ Y P EI++G G ELF+++ C++D
Sbjct: 77 NGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLAD 136
Query: 585 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 644
F+ +K ++PLG TFSFPC+QT L+ G+L++WTK FKA DVV+ L A++R
Sbjct: 137 FMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRH 196
Query: 645 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 704
++ D+D++A+VNDTVGTMMTCAY++P CEVG+I+GTG+NACYME+M N+++VEGD+G+MC
Sbjct: 197 KDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMC 256
Query: 705 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 764
IN EWGAFGD+G L+DIRT +DR +D SLN GKQ +EKMISG+YLGE+VR IL+ K
Sbjct: 257 INTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKA 316
Query: 765 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 824
G LF G+ S L T+G ET+ ++ +E + L R IL LGL + D I V+ VC
Sbjct: 317 GLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCT 376
Query: 825 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 884
+VS R+A LC A +AA++ ++REN+ ++RL TVG+DGTLYK+HP + + +H+ V++L P
Sbjct: 377 IVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVP 436
Query: 885 KCNVSFLLSEDGSGKGAALITAVGVRLRTE 914
C+V FLLSE GS KGAA++TAV R++ +
Sbjct: 437 SCDVRFLLSESGSTKGAAMVTAVASRVQAQ 466
Score = 496 bits (1278), Expect = e-140
Identities = 236/452 (52%), Positives = 333/452 (73%), Gaps = 1/452 (0%)
Query: 18 QVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEK 77
Q K+ID+ L +L+ E L+D+ + R E++ GL + + ATV+MLPT+V +PDG+EK
Sbjct: 466 QRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEK 525
Query: 78 GDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDF 137
G F+ALDLGG++FR+L V++ + ++V M ++++ P I+ G+G +LFDH+ +C+ DF
Sbjct: 526 GKFLALDLGGTNFRVLLVKIRSGR-RSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADF 584
Query: 138 MEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRG 197
++ +K LP+GFTFSFPC+Q ID+ LI WTK FKA+ EG DVV +L +AIK+R
Sbjct: 585 LDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRN 644
Query: 198 DYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCI 257
++D +IVAVVNDTVGTMMTCGY+D +CE+GLI GTG+N CYME++R+I++VEG EG+MCI
Sbjct: 645 EFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCI 704
Query: 258 NTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEG 317
NTEWG FGD+G ++DIRT +D E+D GSLNPGKQ +EKM SGMYLGE+VR IL+ + K+G
Sbjct: 705 NTEWGGFGDNGCIDDIRTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQG 764
Query: 318 LLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTI 377
LLF G+I+ L TRG F T +S IE ++ L + IL +LG++ + +D + V+ VC
Sbjct: 765 LLFRGQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGA 824
Query: 378 VSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPD 437
VS R+A L A L AI+ + R+++G LR TVGVDG+LYK HP +SR +T++ L P
Sbjct: 825 VSRRAAQLCGAGLAAIVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPR 884
Query: 438 SDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQ 469
DV F+LSE GSGKGAA++TAVA RL + ++
Sbjct: 885 CDVTFMLSEDGSGKGAALITAVAKRLQQAQKE 916
>gi|194097330 hexokinase 3 [Homo sapiens]
Length = 923
Score = 945 bits (2443), Expect = 0.0
Identities = 479/897 (53%), Positives = 631/897 (70%), Gaps = 9/897 (1%)
Query: 17 DQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76
D + + + L +++ L I M+ L +P V+MLPT+V S P G+E
Sbjct: 28 DSSELVQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTE 87
Query: 77 KGDFIALDLG--GSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECL 134
+GDF+ L+LG G+S R+L V + + V S+ + P+ ++ G+G QLFD A CL
Sbjct: 88 QGDFVVLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIPQEVMLGAGQQLFDFAAHCL 147
Query: 135 GDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIK 194
+F++ + + + L +GF+FSFPC Q+ +D + LI+WTK F+ SGVEG DVV+LL AI+
Sbjct: 148 SEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIR 207
Query: 195 KRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGR 254
++G Y+ ++VAVVNDTVGTMM C + CEVGL++ TGTNACYMEE RH+ +++ D GR
Sbjct: 208 RQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGR 267
Query: 255 MCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMA 314
+C++ EWG+F DDG+L + T FD +D SLNPG Q FEKM+ G+YLGELVRL+L +A
Sbjct: 268 VCVSVEWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLA 327
Query: 315 KEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHV 374
+ G+LF G +P LL++G V+ +E G IL LG+ P D VQHV
Sbjct: 328 RCGVLFGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQHV 387
Query: 375 CTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRL 434
C V R+A L AA L A+L+ L+ ++ L+ V G + + HP++ T+ L
Sbjct: 388 CAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLL 447
Query: 435 VPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAE 494
P+ DV + S G G+G AMVTAVA RLA R +EETLA F L D L V+ +MR
Sbjct: 448 APECDVSLIPSVDGGGRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQLAAVQAQMRKA 507
Query: 495 MELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVE 554
M GLR + + ++MLP+FVR TPDG+E GDFLALDLGGTNFRVLLV++ +G V+
Sbjct: 508 MAKGLRGEASS---LRMLPTFVRATPDGSERGDFLALDLGGTNFRVLLVRVTTG----VQ 560
Query: 555 MHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAG 614
+ ++IY+IP + QG+G++LFDHIV CI DF G+ G +PLGFTFSFPC+Q LD G
Sbjct: 561 ITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQG 620
Query: 615 ILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEV 674
IL+ WTKGFKA+DC G DVV+LLR+AI RR+ +L+VVA+VNDTVGTMM+C YE+P CE+
Sbjct: 621 ILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCGYEDPRCEI 680
Query: 675 GLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSL 734
GLIVGTG+NACYMEE++NV V GD G+MCINMEWGAFGD+G L + T +D VD+ S+
Sbjct: 681 GLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGDDGSLAMLSTRFDASVDQASI 740
Query: 735 NAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDR 794
N GKQR+EKMISGMYLGEIVR+IL+ T G LFRGQ + L+TR IF+TKFLS+IESD
Sbjct: 741 NPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDS 800
Query: 795 LALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRL 854
LAL QVRAIL+ LGL T DD+++V VC VS+RAAQLCGAG+AAVV+KIRENRGL+ L
Sbjct: 801 LALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEEL 860
Query: 855 NVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRL 911
V+VGVDGTLYKLHP FS ++ TV+EL+P+C V+FL SEDGSGKGAAL+TAV RL
Sbjct: 861 AVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSEDGSGKGAALVTAVACRL 917
Score = 463 bits (1192), Expect = e-130
Identities = 232/447 (51%), Positives = 308/447 (68%), Gaps = 7/447 (1%)
Query: 22 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 81
+++ L RL+ + L + + RK M GL + ++++MLPTFVR+ PDGSE+GDF+
Sbjct: 483 LEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGE---ASSLRMLPTFVRATPDGSERGDFL 539
Query: 82 ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 141
ALDLGG++FR+L V+V V + SE+Y PE + GSG QLFDH+ +C+ DF +K+
Sbjct: 540 ALDLGGTNFRVLLVRVT----TGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQ 595
Query: 142 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 201
+ + LP+GFTFSFPC+Q +D+ IL+ WTK FKAS EG DVV LL +AI +R +
Sbjct: 596 GLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVEL 655
Query: 202 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 261
N+VA+VNDTVGTMM+CGY+D CE+GLI+GTGTNACYMEELR++ V GD GRMCIN EW
Sbjct: 656 NVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEW 715
Query: 262 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 321
GAFGDDGSL + T FD +D+ S+NPGKQ FEKM+SGMYLGE+VR IL+ + G+LF
Sbjct: 716 GAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFR 775
Query: 322 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 381
G+ L TR F T +S IE + L + IL LG+ + DD + V VC VS R
Sbjct: 776 GQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQR 835
Query: 382 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 441
+A L A + A++ ++R+N+G L +VGVDG+LYK HP++S T+R L P V
Sbjct: 836 AAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVT 895
Query: 442 FLLSESGSGKGAAMVTAVAYRLAEQHR 468
FL SE GSGKGAA+VTAVA RLA+ R
Sbjct: 896 FLQSEDGSGKGAALVTAVACRLAQLTR 922
>gi|15967161 glucokinase isoform 3 [Homo sapiens]
Length = 464
Score = 506 bits (1304), Expect = e-143
Identities = 245/451 (54%), Positives = 336/451 (74%), Gaps = 2/451 (0%)
Query: 462 RLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPD 521
+L + + Q+E+ LA F L ++ L +V +RM+ EM+ GLR +TH A VKMLP++VR TP+
Sbjct: 7 QLPQPNSQVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPE 66
Query: 522 GTENGDFLALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIV 579
G+E GDFL+LDLGGTNFRV+LVK+ G++ +V+ +++Y+IP + M GT E LFD+I
Sbjct: 67 GSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYIS 126
Query: 580 SCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRD 639
CISDFLD +K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRD
Sbjct: 127 ECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRD 186
Query: 640 AIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGD 699
AIKRR +F++DVVA+VNDTV TM++C YE+ CEVG+IVGTG NACYMEEM+NVE+VEGD
Sbjct: 187 AIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGD 246
Query: 700 QGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILI 759
+G+MC+N EWGAFGD+G LD+ YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+
Sbjct: 247 EGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLL 306
Query: 760 DFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILV 819
+ LF G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V
Sbjct: 307 RLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIV 366
Query: 820 KTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTV 879
+ C VS RAA +C AG+A V++++RE+R D + +TVGVDG++YKLHP F H +V
Sbjct: 367 RRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASV 426
Query: 880 KELSPKCNVSFLLSEDGSGKGAALITAVGVR 910
+ L+P C ++F+ SE+GSG+GAAL++AV +
Sbjct: 427 RRLTPSCEITFIESEEGSGRGAALVSAVACK 457
Score = 474 bits (1220), Expect = e-133
Identities = 222/446 (49%), Positives = 321/446 (71%), Gaps = 2/446 (0%)
Query: 21 KIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 80
++++ L +L +E L +M R +KEM GL + + A+VKMLPT+VRS P+GSE GDF
Sbjct: 14 QVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDF 73
Query: 81 IALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM 138
++LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD+++EC+ DF+
Sbjct: 74 LSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFL 133
Query: 139 EKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGD 198
+K ++K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV LL AIK+RGD
Sbjct: 134 DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGD 193
Query: 199 YDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN 258
++ ++VA+VNDTV TM++C Y+D CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+N
Sbjct: 194 FEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVN 253
Query: 259 TEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGL 318
TEWGAFGD G L++ E+DR +D S NPG+QL+EK++ G Y+GELVRL+L+++ E L
Sbjct: 254 TEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENL 313
Query: 319 LFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIV 378
LF G + +L TRG F T VS +E + IL+ LG+ PS DC V+ C V
Sbjct: 314 LFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESV 373
Query: 379 SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDS 438
S R+A++ +A L ++NR+R+++ +R TVGVDGS+YK HP + RFH ++RRL P
Sbjct: 374 STRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSC 433
Query: 439 DVRFLLSESGSGKGAAMVTAVAYRLA 464
++ F+ SE GSG+GAA+V+AVA + A
Sbjct: 434 EITFIESEEGSGRGAALVSAVACKKA 459
>gi|4503951 glucokinase isoform 1 [Homo sapiens]
Length = 465
Score = 504 bits (1298), Expect = e-142
Identities = 244/449 (54%), Positives = 334/449 (74%), Gaps = 2/449 (0%)
Query: 464 AEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGT 523
A + ++E+ LA F L ++ L +V +RM+ EM+ GLR +TH A VKMLP++VR TP+G+
Sbjct: 10 AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69
Query: 524 ENGDFLALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIVSC 581
E GDFL+LDLGGTNFRV+LVK+ G++ +V+ +++Y+IP + M GT E LFD+I C
Sbjct: 70 EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129
Query: 582 ISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAI 641
ISDFLD +K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRDAI
Sbjct: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189
Query: 642 KRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQG 701
KRR +F++DVVA+VNDTV TM++C YE+ CEVG+IVGTG NACYMEEM+NVE+VEGD+G
Sbjct: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249
Query: 702 QMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDF 761
+MC+N EWGAFGD+G LD+ YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+
Sbjct: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309
Query: 762 TKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKT 821
+ LF G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+
Sbjct: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369
Query: 822 VCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKE 881
C VS RAA +C AG+A V++++RE+R D + +TVGVDG++YKLHP F H +V+
Sbjct: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429
Query: 882 LSPKCNVSFLLSEDGSGKGAALITAVGVR 910
L+P C ++F+ SE+GSG+GAAL++AV +
Sbjct: 430 LTPSCEITFIESEEGSGRGAALVSAVACK 458
Score = 476 bits (1225), Expect = e-134
Identities = 223/447 (49%), Positives = 322/447 (72%), Gaps = 2/447 (0%)
Query: 20 KKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGD 79
+K+++ L +L +E L +M R +KEM GL + + A+VKMLPT+VRS P+GSE GD
Sbjct: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73
Query: 80 FIALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDF 137
F++LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD+++EC+ DF
Sbjct: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 133
Query: 138 MEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRG 197
++K ++K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV LL AIK+RG
Sbjct: 134 LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 193
Query: 198 DYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCI 257
D++ ++VA+VNDTV TM++C Y+D CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+
Sbjct: 194 DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCV 253
Query: 258 NTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEG 317
NTEWGAFGD G L++ E+DR +D S NPG+QL+EK++ G Y+GELVRL+L+++ E
Sbjct: 254 NTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDEN 313
Query: 318 LLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTI 377
LLF G + +L TRG F T VS +E + IL+ LG+ PS DC V+ C
Sbjct: 314 LLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACES 373
Query: 378 VSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPD 437
VS R+A++ +A L ++NR+R+++ +R TVGVDGS+YK HP + RFH ++RRL P
Sbjct: 374 VSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPS 433
Query: 438 SDVRFLLSESGSGKGAAMVTAVAYRLA 464
++ F+ SE GSG+GAA+V+AVA + A
Sbjct: 434 CEITFIESEEGSGRGAALVSAVACKKA 460
>gi|15967159 glucokinase isoform 2 [Homo sapiens]
Length = 466
Score = 503 bits (1294), Expect = e-142
Identities = 243/443 (54%), Positives = 331/443 (74%), Gaps = 2/443 (0%)
Query: 470 IEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFL 529
+E+ LA F L ++ L +V +RM+ EM+ GLR +TH A VKMLP++VR TP+G+E GDFL
Sbjct: 17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76
Query: 530 ALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLD 587
+LDLGGTNFRV+LVK+ G++ +V+ +++Y+IP + M GT E LFD+I CISDFLD
Sbjct: 77 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136
Query: 588 YMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEF 647
+K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRDAIKRR +F
Sbjct: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196
Query: 648 DLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINM 707
++DVVA+VNDTV TM++C YE+ CEVG+IVGTG NACYMEEM+NVE+VEGD+G+MC+N
Sbjct: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256
Query: 708 EWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFL 767
EWGAFGD+G LD+ YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+ + L
Sbjct: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316
Query: 768 FRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVS 827
F G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+ C VS
Sbjct: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376
Query: 828 RRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCN 887
RAA +C AG+A V++++RE+R D + +TVGVDG++YKLHP F H +V+ L+P C
Sbjct: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436
Query: 888 VSFLLSEDGSGKGAALITAVGVR 910
++F+ SE+GSG+GAAL++AV +
Sbjct: 437 ITFIESEEGSGRGAALVSAVACK 459
Score = 474 bits (1219), Expect = e-133
Identities = 222/445 (49%), Positives = 320/445 (71%), Gaps = 2/445 (0%)
Query: 22 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 81
+++ L +L +E L +M R +KEM GL + + A+VKMLPT+VRS P+GSE GDF+
Sbjct: 17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76
Query: 82 ALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 139
+LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD+++EC+ DF++
Sbjct: 77 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136
Query: 140 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 199
K ++K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV LL AIK+RGD+
Sbjct: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196
Query: 200 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 259
+ ++VA+VNDTV TM++C Y+D CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+NT
Sbjct: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256
Query: 260 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 319
EWGAFGD G L++ E+DR +D S NPG+QL+EK++ G Y+GELVRL+L+++ E LL
Sbjct: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316
Query: 320 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 379
F G + +L TRG F T VS +E + IL+ LG+ PS DC V+ C VS
Sbjct: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376
Query: 380 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 439
R+A++ +A L ++NR+R+++ +R TVGVDGS+YK HP + RFH ++RRL P +
Sbjct: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436
Query: 440 VRFLLSESGSGKGAAMVTAVAYRLA 464
+ F+ SE GSG+GAA+V+AVA + A
Sbjct: 437 ITFIESEEGSGRGAALVSAVACKKA 461
>gi|164663810 ribosomal modification protein rimK-like family member
A [Homo sapiens]
Length = 391
Score = 34.7 bits (78), Expect = 0.42
Identities = 33/143 (23%), Positives = 59/143 (41%), Gaps = 30/143 (20%)
Query: 578 IVSCISDFLDYMGIKGPRMPLGFTFSFPCQQT---------SLDAGILITWTKG------ 622
I++CI+ F + + G +P+ TFS+ + L +++ T+G
Sbjct: 105 ILNCINKFWTFQELAGHGVPMPDTFSYGGHEDFSKMIDEAEPLGYPVVVKSTRGHRGKAV 164
Query: 623 FKATD---------CVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYE---EP 670
F A D + HDV L + +K D+ VV V +G+M+ C+ + +
Sbjct: 165 FLARDKHHLSDICHLIRHDVPYLFQKYVKESHGKDIRVVVVGGQVIGSMLRCSTDGRMQS 224
Query: 671 TCEVGLIVGTGSNACYMEEMKNV 693
C +G G G E+ K +
Sbjct: 225 NCSLG---GVGVKCPLTEQGKQL 244
>gi|134254462 ribosomal modification protein rimK-like family member
B [Homo sapiens]
Length = 386
Score = 33.5 bits (75), Expect = 0.93
Identities = 41/191 (21%), Positives = 75/191 (39%), Gaps = 51/191 (26%)
Query: 578 IVSCISDFLDYMGIKGPRMPLGFTFSFPCQQT---------SLDAGILITWTKG------ 622
I++C++ F + + G +PL TFS+ + L+ +++ T+G
Sbjct: 109 ILNCVNKFWTFQELAGHGVPLPDTFSYGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAV 168
Query: 623 FKATD---------CVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYE---EP 670
F A D + H+ L + +K D+ V+ V VGTM+ C+ + +
Sbjct: 169 FLARDKHHLADLSHLIRHEAPYLFQKYVKESHGRDVRVIVVGGRVVGTMLRCSTDGRMQS 228
Query: 671 TCEVGLIVGTGSNACYMEEMK---------------NVEMVEGDQGQMCI-----NMEWG 710
C +G G G E+ K ++++ D G C+ N+ +
Sbjct: 229 NCSLG---GVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFI 285
Query: 711 AFGDNGCLDDI 721
AF D C D+
Sbjct: 286 AF-DKACNLDV 295
>gi|21389509 KPL2 protein isoform 2 [Homo sapiens]
Length = 514
Score = 32.0 bits (71), Expect = 2.7
Identities = 17/76 (22%), Positives = 37/76 (48%), Gaps = 2/76 (2%)
Query: 459 VAYRLAEQHRQIEETLAHFHLTK-DMLLEVKKRMRA-EMELGLRKQTHNNAVVKMLPSFV 516
+ YR E+++ ++E LAH H K + ++K+ R ++E + N ++ + + +
Sbjct: 155 ITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAI 214
Query: 517 RRTPDGTENGDFLALD 532
+ P N AL+
Sbjct: 215 IQIPKPASNRTLKALE 230
>gi|145699133 KPL2 protein isoform 1 [Homo sapiens]
Length = 1822
Score = 32.0 bits (71), Expect = 2.7
Identities = 17/76 (22%), Positives = 37/76 (48%), Gaps = 2/76 (2%)
Query: 459 VAYRLAEQHRQIEETLAHFHLTK-DMLLEVKKRMRA-EMELGLRKQTHNNAVVKMLPSFV 516
+ YR E+++ ++E LAH H K + ++K+ R ++E + N ++ + + +
Sbjct: 155 ITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAI 214
Query: 517 RRTPDGTENGDFLALD 532
+ P N AL+
Sbjct: 215 IQIPKPASNRTLKALE 230
>gi|42415492 chromosome 14 open reading frame 106 [Homo sapiens]
Length = 1132
Score = 30.4 bits (67), Expect = 7.9
Identities = 23/77 (29%), Positives = 37/77 (48%), Gaps = 4/77 (5%)
Query: 277 FDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMA--KEGLLFEGRITPELLTRGKF 334
F I G+L P K L + S + L + + +KM +F+ + E T
Sbjct: 30 FFDSIPSGTLTPVKDLVKYQNSSLKLNDHKKNQFLKMTTFNNKNIFQSTMLTEATTSN-- 87
Query: 335 NTSDVSAIEKNKEGLHN 351
++ D+SAI+ NK+GL N
Sbjct: 88 SSLDISAIKPNKDGLKN 104
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,028,421
Number of Sequences: 37866
Number of extensions: 1396269
Number of successful extensions: 2805
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2760
Number of HSP's gapped (non-prelim): 30
length of query: 917
length of database: 18,247,518
effective HSP length: 111
effective length of query: 806
effective length of database: 14,044,392
effective search space: 11319779952
effective search space used: 11319779952
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.