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Search of human proteins with 187960042
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187960042 selectin E precursor [Homo sapiens]
(610 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187960042 selectin E precursor [Homo sapiens] 1305 0.0
gi|157419154 selectin P precursor [Homo sapiens] 533 e-151
gi|4506875 selectin L precursor [Homo sapiens] 339 4e-93
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 206 4e-53
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 206 4e-53
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 206 4e-53
gi|148886654 polydom [Homo sapiens] 196 7e-50
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 179 9e-45
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 177 2e-44
gi|42544177 complement component (3d/Epstein Barr virus) recepto... 159 9e-39
gi|54792123 complement component (3d/Epstein Barr virus) recepto... 159 9e-39
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 155 1e-37
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 155 1e-37
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ... 145 1e-34
gi|4502503 complement component 4 binding protein, alpha chain p... 115 2e-25
gi|153266841 apolipoprotein H precursor [Homo sapiens] 105 1e-22
gi|5454086 sushi-repeat-containing protein, X-linked [Homo sapiens] 99 1e-20
gi|110611237 coagulation factor XIII B subunit precursor [Homo s... 98 3e-20
gi|62739188 complement factor H isoform b precursor [Homo sapiens] 95 2e-19
gi|62739186 complement factor H isoform a precursor [Homo sapiens] 95 2e-19
gi|38045915 pregnancy-associated plasma protein A preproprotein ... 92 1e-18
gi|27502421 CD46 antigen, complement regulatory protein isoform ... 90 7e-18
gi|27502417 CD46 antigen, complement regulatory protein isoform ... 90 7e-18
gi|27502415 CD46 antigen, complement regulatory protein isoform ... 90 7e-18
gi|27502407 CD46 antigen, complement regulatory protein isoform ... 90 7e-18
gi|24432108 CD46 antigen, complement regulatory protein isoform ... 90 7e-18
gi|27502413 CD46 antigen, complement regulatory protein isoform ... 89 9e-18
gi|27502402 CD46 antigen, complement regulatory protein isoform ... 89 9e-18
gi|27502425 CD46 antigen, complement regulatory protein isoform ... 89 9e-18
gi|27502423 CD46 antigen, complement regulatory protein isoform ... 89 9e-18
>gi|187960042 selectin E precursor [Homo sapiens]
Length = 610
Score = 1305 bits (3378), Expect = 0.0
Identities = 610/610 (100%), Positives = 610/610 (100%)
Query: 1 MIASQFLSALTLVLLIKESGAWSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLN 60
MIASQFLSALTLVLLIKESGAWSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLN
Sbjct: 1 MIASQFLSALTLVLLIKESGAWSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLN 60
Query: 61 SILSYSPSYYWIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREK 120
SILSYSPSYYWIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREK
Sbjct: 61 SILSYSPSYYWIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREK 120
Query: 121 DVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNC 180
DVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNC
Sbjct: 121 DVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNC 180
Query: 181 TALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVV 240
TALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVV
Sbjct: 181 TALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVV 240
Query: 241 ECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCK 300
ECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCK
Sbjct: 241 ECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCK 300
Query: 301 AVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIP 360
AVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIP
Sbjct: 301 AVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIP 360
Query: 361 VCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDN 420
VCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDN
Sbjct: 361 VCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDN 420
Query: 421 EKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ 480
EKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ
Sbjct: 421 EKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ 480
Query: 481 WTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHW 540
WTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHW
Sbjct: 481 WTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHW 540
Query: 541 SGLLPTCEAPTESNIPLVAGLSAAGLSLLTLAPFLLWLRKCLRKAKKFVPASSCQSLESD 600
SGLLPTCEAPTESNIPLVAGLSAAGLSLLTLAPFLLWLRKCLRKAKKFVPASSCQSLESD
Sbjct: 541 SGLLPTCEAPTESNIPLVAGLSAAGLSLLTLAPFLLWLRKCLRKAKKFVPASSCQSLESD 600
Query: 601 GSYQKPSYIL 610
GSYQKPSYIL
Sbjct: 601 GSYQKPSYIL 610
>gi|157419154 selectin P precursor [Homo sapiens]
Length = 830
Score = 533 bits (1374), Expect = e-151
Identities = 240/536 (44%), Positives = 329/536 (61%), Gaps = 6/536 (1%)
Query: 17 KESGAWSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLNSILSYSPSYYWIGIRK 76
KE AW+Y+ ST+A +++ + YCQ RYT LVAIQNK EI+YLN +L Y SYYWIGIRK
Sbjct: 37 KEVAAWTYHYSTKAYSWNISRKYCQNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRK 96
Query: 77 VNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLA 136
N W WVGT+K LT EA+NWA EPNN++ +EDCVEIYIK G WNDE C KKK A
Sbjct: 97 NNKTWTWVGTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHA 156
Query: 137 LCYTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHP 196
LCYTA+C + SCS GEC+ETI NYTC C PGF G +CE + C LE P+H + CSHP
Sbjct: 157 LCYTASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVRECGELELPQHVLMNCSHP 216
Query: 197 LGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECF 256
LGNFS+NS CS C GY + ++C++SG W+ P C +C + P G + C
Sbjct: 217 LGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCL 276
Query: 257 QNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVR 316
+ +F ++C+F CEEGF L+G + +QCT+SG W P CKAV C+ + P G++
Sbjct: 277 HSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMD 336
Query: 317 CSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERG 376
C H P F + SSC F C+ G+ ++G + C G W+ +P CEA C L +P G
Sbjct: 337 CVH-PLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHG 395
Query: 377 YMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQP 436
M+C PS +F+Y ++C F C +GF+L+G+ ++C G+W P C+A++C + P
Sbjct: 396 SMDCSPSLR-AFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVP 454
Query: 437 PKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSL 496
+ V C+H P G F Y+S C+F+C EG L G++ L+C + G W P CQ + C+ L
Sbjct: 455 NEARVNCSH-PFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPL 513
Query: 497 AVPGKINMSC---SGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEA 549
P M+C G + + C+F C EG++L+G C +G W+ P CEA
Sbjct: 514 LSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEA 569
Score = 345 bits (884), Expect = 9e-95
Identities = 174/487 (35%), Positives = 257/487 (52%), Gaps = 42/487 (8%)
Query: 137 LCYTAACTNTSCSGHG--ECVETINNY----TCK--CDPGF-----SGLKCE-------- 175
+C C + G +CV + + +CK C PG+ L+C
Sbjct: 318 VCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAP 377
Query: 176 ----QIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWS 231
+ ++C LESP HGS+ CS L F Y+++CS C G++ + ++C + G+W+
Sbjct: 378 LPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWT 437
Query: 232 APIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN 291
AP P C ++C + P V C G+F + + C+F C EG L+GA LQC ++GN
Sbjct: 438 APAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGN 497
Query: 292 WDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTT 351
W++ P C+A+ C + PQNG++ C P G ++KS+C F C+EG+ L GP +++CT
Sbjct: 498 WNSVPPECQAIPCTPLLSPQNGTMTCVQ-PLGSSSYKSTCQFICDEGYSLSGPERLDCTR 556
Query: 352 QGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQ 411
G+WT P+CEA +C L PE+G ++C G F GS+C FSC+ GF L+G ++
Sbjct: 557 SGRWTDSPPMCEAIKCPELFAPEQGSLDC-SDTRGEFNVGSTCHFSCDNGFKLEGPNNVE 615
Query: 412 CGPTGEWDNEKPTCEA--------VRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEE 463
C +G W PTC+ V+C A+ P +G + C H P G F + ++C F C
Sbjct: 616 CTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHP-GTFGFNTTCYFGCNA 674
Query: 464 GFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCS---GEPVFGTVCKFAC 520
GF L G + L C GQWT P+C+ VKCS L V I M+CS G +G++C F C
Sbjct: 675 GFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHC 734
Query: 521 PEGWTLNGSAARTCGATGHWSGLLPTCEA---PTESNIPLVAGLSAAGLSLLTLAPFLLW 577
EG LNGSA C GHWS +PTC+A + + G A+ + L+ L
Sbjct: 735 LEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEALTYFGGAVASTIGLIMGGTLLAL 794
Query: 578 LRKCLRK 584
LRK R+
Sbjct: 795 LRKRFRQ 801
>gi|4506875 selectin L precursor [Homo sapiens]
Length = 372
Score = 339 bits (870), Expect = 4e-93
Identities = 147/279 (52%), Positives = 187/279 (67%)
Query: 22 WSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLNSILSYSPSYYWIGIRKVNNVW 81
W+Y+ S + M + A +C+ YT LVAIQNK EIEYL L +S SYYWIGIRK+ +W
Sbjct: 39 WTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIW 98
Query: 82 VWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLALCYTA 141
WVGT K LTEEA+NW GEPNN++ EDCVEIYIKR KD G WND+ C K K ALCYTA
Sbjct: 99 TWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTA 158
Query: 142 ACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFS 201
+C SCSGHGECVE INNYTC CD G+ G +C+ ++ C LE+PE G++ C+HPLGNFS
Sbjct: 159 SCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFS 218
Query: 202 YNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGS 261
++S C+ SC G + +E C G WS+P P C V++C+ ++ P G + C S
Sbjct: 219 FSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLAS 278
Query: 262 FPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCK 300
F + + CTF C EG EL+G + C SSG W N P C+
Sbjct: 279 FSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQ 317
Score = 114 bits (284), Expect = 3e-25
Identities = 55/146 (37%), Positives = 79/146 (54%), Gaps = 4/146 (2%)
Query: 360 PVCE-AFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEW 418
P C+ QC L PE G M+C G+F + S C FSC +G L G + CGP G W
Sbjct: 189 PQCQFVIQCEPLEAPELGTMDCTHPL-GNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNW 247
Query: 419 DNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQ 478
+ +PTC+ ++C+ + P G++ C+H P+ F++ S+C F C EG EL G + C S
Sbjct: 248 SSPEPTCQVIQCEPLSAPDLGIMNCSH-PLASFSFTSACTFICSEGTELIGKKKTICESS 306
Query: 479 GQWTEEVPSCQVV-KCSSLAVPGKIN 503
G W+ P CQ + K S+ G N
Sbjct: 307 GIWSNPSPICQKLDKSFSMIKEGDYN 332
Score = 103 bits (258), Expect = 4e-22
Identities = 60/178 (33%), Positives = 89/178 (50%), Gaps = 16/178 (8%)
Query: 423 PTCE-AVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQW 481
P C+ ++C+ + P G + C H P+G F++ S CAFSC EG L G + C G W
Sbjct: 189 PQCQFVIQCEPLEAPELGTMDCTH-PLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNW 247
Query: 482 TEEVPSCQVVKCSSLAVPGKINMSCSGEPV----FGTVCKFACPEGWTLNGSAARTCGAT 537
+ P+CQV++C L+ P M+CS P+ F + C F C EG L G C ++
Sbjct: 248 SSPEPTCQVIQCEPLSAPDLGIMNCS-HPLASFSFTSACTFICSEGTELIGKKKTICESS 306
Query: 538 GHWSGLLPTCEAPTES--------NIPLVAGLSAAGLSLLTLAPFLLWLRKCLRKAKK 587
G WS P C+ +S PL ++ + LA F++WL + L+K KK
Sbjct: 307 GIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLA-FIIWLARRLKKGKK 363
Score = 103 bits (258), Expect = 4e-22
Identities = 49/131 (37%), Positives = 68/131 (51%), Gaps = 3/131 (2%)
Query: 297 PTCK-AVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQW 355
P C+ + C + P+ G++ C+H P G F+F S C F+C EG L G + C G W
Sbjct: 189 PQCQFVIQCEPLEAPELGTMDCTH-PLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNW 247
Query: 356 TQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPT 415
+ P C+ QC LS P+ G MNC SF + S+C F C +G L G K+ C +
Sbjct: 248 SSPEPTCQVIQCEPLSAPDLGIMNC-SHPLASFSFTSACTFICSEGTELIGKKKTICESS 306
Query: 416 GEWDNEKPTCE 426
G W N P C+
Sbjct: 307 GIWSNPSPICQ 317
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 206 bits (525), Expect = 4e-53
Identities = 122/401 (30%), Positives = 183/401 (45%), Gaps = 21/401 (5%)
Query: 163 CKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGN-FSYNSSCSISCDRGYLPSSMET 221
C+ D +SG Q+ +C + GS + GN F++N + SC+ GYL
Sbjct: 2817 CQQDHNWSG----QLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTK 2872
Query: 222 MQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGA 281
QC ++ +WS P P C VV C PAN E G+F + T +DC G+ L G+
Sbjct: 2873 AQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGS 2932
Query: 282 QSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGE-FTFKSSCNFTCEEGFM 340
L C +G WD P C + C P N + +GE +TF S+ +++C
Sbjct: 2933 SVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVL------SGEKYTFGSTVHYSCTGKRS 2986
Query: 341 LQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQ 400
L G + C G W+ P C +P G +FR S+ ++C+
Sbjct: 2987 LLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDP--GTPGHGSRQESNFRTKSTVRYACDT 3044
Query: 401 GFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFS 460
G++L GS+ C G W +P C+AV+C G V I T+ SS +S
Sbjct: 3045 GYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKV----FRIDGTTFSSSVIYS 3100
Query: 461 CEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFAC 520
C EG+ L G + +CT+ G W+ +P+C ++ C +P + + V G + C
Sbjct: 3101 CMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPAN-GLRYGDDYVVGQNVSYMC 3159
Query: 521 PEGWT--LNGSAARTCGATGHWSGLLPTCEAPTESNIPLVA 559
G+T LNGS RTC G WSG++PTC A T P ++
Sbjct: 3160 QPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQIS 3200
Score = 164 bits (415), Expect = 2e-40
Identities = 120/434 (27%), Positives = 174/434 (40%), Gaps = 42/434 (9%)
Query: 140 TAACTNTSCSGHGECVETINNYTCK------CDPGFSGLKCEQIVNCTALES-----PEH 188
T C + GHG E+ N+ K CD G+ L + C A S PE
Sbjct: 3013 TGTCGDPGTPGHGSRQES--NFRTKSTVRYACDTGYI-LHGSEERTCLANGSWTGRQPEC 3069
Query: 189 GSLVCSHP----------LGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACN 238
++ C +P + +++SS SC GY+ S QC ++G WS +P C
Sbjct: 3070 KAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCT 3129
Query: 239 VVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGF--ELMGAQSLQCTSSGNWDNEK 296
++ C PANG + + ++ C+ G+ EL G++ CT +G W
Sbjct: 3130 IISCGDPGIPANGL----RYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVM 3185
Query: 297 PTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWT 356
PTC+AVTC Q NG + ++ F + S ++ C G+ L PA + C G W+
Sbjct: 3186 PTCRAVTCPTPPQISNGRLEGTN-----FDWGFSISYICSPGYELSFPAVLTCVGNGTWS 3240
Query: 357 QQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTG 416
++P C C P +G SF Y S FSC F+L GS C G
Sbjct: 3241 GEVPQCLPKFCGDPGIPAQG-----KREGKSFIYQSEVSFSCNFPFILVGSSTRICQADG 3295
Query: 417 EWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECT 476
W P C + P ++ G F S F C++G L GST C
Sbjct: 3296 TWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFG-FQVGSVVQFHCKKGHLLQGSTTRTCL 3354
Query: 477 SQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTL-NGSAARTCG 535
W+ P C C P N+ P G + C G+ L G+ R C
Sbjct: 3355 PDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCR 3414
Query: 536 ATGHWSGLLPTCEA 549
+ W+G +P CEA
Sbjct: 3415 SDNTWTGKVPICEA 3428
Score = 160 bits (405), Expect = 3e-39
Identities = 110/380 (28%), Positives = 160/380 (42%), Gaps = 30/380 (7%)
Query: 180 CTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSG----EWSAPIP 235
C+ ESP HG ++ S G NS +CDRG+ + C S W AP+P
Sbjct: 2529 CSTPESPPHGYII-SQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVP 2585
Query: 236 ACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQ--SLQCTSSGNWD 293
AC + C P NG + + T T+ C +G+ L + + C S G W
Sbjct: 2586 ACQAISCGIPKAPTNGGILTTD----YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWS 2641
Query: 294 NEK--PTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTT 351
N P C VTC ++ R + +K+ F+C+ G+ GPA +EC
Sbjct: 2642 NHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLP 2701
Query: 352 QGQWT--QQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKR 409
G W+ + P C+ C L P G N + + + YGS+ F+C+ GF+L GS
Sbjct: 2702 NGTWSWRNERPYCQIISCGELPTPPNG--NKIGTQTS---YGSTAIFTCDLGFMLVGSAV 2756
Query: 410 LQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGE-FTYKSSCAFSCEEGFELH 468
+C +G W + C A C G V IGE + Y+ + + C GF L
Sbjct: 2757 RECLSSGLWSESETRCLAGHCGIPELIVNGQV------IGENYGYRDTVVYQCNPGFRLI 2810
Query: 469 GSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNG 528
GS+ C W+ ++PSC V C P S +G F V F+C G+ + G
Sbjct: 2811 GSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFN-FNDVVTFSCNIGYLMQG 2869
Query: 529 SAARTCGATGHWSGLLPTCE 548
C A WS P C+
Sbjct: 2870 PTKAQCQANRQWSHPPPMCK 2889
Score = 159 bits (402), Expect = 7e-39
Identities = 107/385 (27%), Positives = 159/385 (41%), Gaps = 37/385 (9%)
Query: 186 PEHGSLVCSHPL---------GNFSYNSSCSISCD--RGYLPSSMETMQCMSSGEWSAPI 234
PE + C HP +++ S+ SC R L S T C +G WS
Sbjct: 2948 PECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRT--CQLNGHWSGSQ 3005
Query: 235 PACN---VVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN 291
P C+ C P +G + +F +T + C+ G+ L G++ C ++G+
Sbjct: 3006 PHCSGDATGTCGDPGTPGHGS----RQESNFRTKSTVRYACDTGYILHGSEERTCLANGS 3061
Query: 292 WDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTT 351
W +P CKAV C NG V TF SS ++C EG++L GP+ +CT
Sbjct: 3062 WTGRQPECKAVQCGNPGTTANGKVFRIDGT----TFSSSVIYSCMEGYILSGPSVRQCTA 3117
Query: 352 QGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFV--LKGSKR 409
G W+ +P C C P G + G + + C+ G+ L GS+
Sbjct: 3118 NGTWSGTLPNCTIISCGDPGIPANGLRY-----GDDYVVGQNVSYMCQPGYTMELNGSRI 3172
Query: 410 LQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHG 469
C G W PTC AV C Q G + + F + S ++ C G+EL
Sbjct: 3173 RTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN-----FDWGFSISYICSPGYELSF 3227
Query: 470 STQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGS 529
L C G W+ EVP C C +P + ++ + F+C + L GS
Sbjct: 3228 PAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSF-IYQSEVSFSCNFPFILVGS 3286
Query: 530 AARTCGATGHWSGLLPTCEAPTESN 554
+ R C A G WSG P C PT+++
Sbjct: 3287 STRICQADGTWSGSSPHCIEPTQTS 3311
Score = 94.4 bits (233), Expect = 3e-19
Identities = 65/234 (27%), Positives = 94/234 (40%), Gaps = 22/234 (9%)
Query: 329 SSCNFTCEEGFMLQGPAQVECTTQGQ----WTQQIPVCEAFQCTALSNPERGYMNCLPSA 384
S + C+ GF L G + C W +P C+A C P G +
Sbjct: 2550 SVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGI-----L 2604
Query: 385 SGSFRYGSSCEFSCEQGFVLKGSKRLQ---CGPTGEWDNEK--PTCEAVRCDAVHQ--PP 437
+ + G+ + C G+ L SK L C G W N P C V C +++
Sbjct: 2605 TTDYLVGTRVTYFCNDGYRLS-SKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILE 2663
Query: 438 KGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWT--EEVPSCQVVKCSS 495
G R + + YK+ FSC+ G+ G +EC G W+ E P CQ++ C
Sbjct: 2664 HGRWRIVNG--SHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGE 2721
Query: 496 LAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEA 549
L P N + +G+ F C G+ L GSA R C ++G WS C A
Sbjct: 2722 LPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLA 2774
Score = 75.5 bits (184), Expect = 1e-13
Identities = 45/176 (25%), Positives = 72/176 (40%), Gaps = 5/176 (2%)
Query: 199 NFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQN 258
+F Y S S SC+ ++ T C + G WS P C + NP N
Sbjct: 3266 SFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNN 3325
Query: 259 PGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCS 318
F + F C++G L G+ + C W +P C +C+ P + +V
Sbjct: 3326 TFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGM 3385
Query: 319 HSPAGEFTFKSSCNFTCEEGFMLQGPAQVE-CTTQGQWTQQIPVCEAFQCTALSNP 373
P+ +T +TC+ GF L G + C + WT ++P+CEA + +P
Sbjct: 3386 DLPSHGYTLI----YTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDP 3437
Score = 57.0 bits (136), Expect = 5e-08
Identities = 103/471 (21%), Positives = 165/471 (35%), Gaps = 115/471 (24%)
Query: 144 TNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYN 203
+N H E V T+N Y+C DPG P HG H +FS
Sbjct: 952 SNNGFKIHYESV-TVNTYSC-LDPGI----------------PVHGRRY-GH---DFSIG 989
Query: 204 SSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPAN-----GFVECFQN 258
S+ S SCD GY S E + C + WS P+P C+ + V P+ G+ E + N
Sbjct: 990 STVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPN 1049
Query: 259 PGSFPWNTTC-----------TFDCEEGFE----------------LMGAQSLQCTSSGN 291
+ W TF E+ + L G+ ++G
Sbjct: 1050 SLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGL 1109
Query: 292 WDNEKPTCKAVT--------------------CRAVRQPQNGSVRCSHSPAGEFTFKSSC 331
+ N + + ++ C PQ GS F +
Sbjct: 1110 YGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGS-----RIGFNFGIGDTL 1164
Query: 332 NFTCEEGFMLQGPAQVECTTQGQ--WTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFR 389
F+C G+ L+G +++ C G+ W+ +P C A +C A + G + P+ ++
Sbjct: 1165 TFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA-ECGASATNNEGIL-LSPNYPLNYE 1222
Query: 390 YGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIG 449
C +S + G+ N + V + G + H +G
Sbjct: 1223 NNHECIYSIQV-------------QAGKGINISARTFHLAQGDVLKIYDGKDKTTHL-LG 1268
Query: 450 EFTYKSSCAFSCEEGFELHGSTQ---LECTSQGQWTEE-----VPSCQVVKCSSLAVPGK 501
FT S G L ++ LE S + T+E S ++ C +P +
Sbjct: 1269 AFTGASM------RGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIP-Q 1321
Query: 502 INMSCSGEPVF-GTVCKFACPEGWTLNGSAARTC--GATGHWSGLLPTCEA 549
S + F G+ + C G+TL+GS+ C G W LP+C A
Sbjct: 1322 FGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIA 1372
Score = 52.4 bits (124), Expect = 1e-06
Identities = 65/276 (23%), Positives = 107/276 (38%), Gaps = 40/276 (14%)
Query: 266 TTCTFDCEEGFELMGAQSLQCTSSGN----WDNEKPTCKAVTCRAVRQPQNGSVRCSHSP 321
+T T+ C+ G+ L G +L C + W+ P+C A C + G+V + P
Sbjct: 1681 STVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA-PCGSRSTGSEGTVLSPNYP 1739
Query: 322 AGEFTFKSSCNFTCE--EGFMLQGPAQVECTTQGQWTQQI--PVCEAFQCTALSNPERGY 377
++ +C ++ + F++ G T+ + P ++ ++LS G
Sbjct: 1740 KN-YSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSG- 1797
Query: 378 MNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPP 437
LP +SG+ + F+ KG + P + +C +V +P
Sbjct: 1798 -ESLPLSSGN---QITIRFTSVGPITAKGFHFVY--------QAVPRTSSTQCSSVPEPR 1845
Query: 438 KGLVRCAHSPIG-EFTYKSSCAFSCEEGFELHGSTQLEC----TSQGQWTEEVPSCQVVK 492
G IG EF SS F C G+ LHGS + C S QW + +P+C +V
Sbjct: 1846 FG------RRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC-IVP 1898
Query: 493 CSSLAVPGKINMSCSGEPV-----FGTVCKFACPEG 523
C + K + G P V K PEG
Sbjct: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEG 1934
Score = 51.2 bits (121), Expect = 3e-06
Identities = 57/251 (22%), Positives = 87/251 (34%), Gaps = 63/251 (25%)
Query: 367 CTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGE----WDNEK 422
C PE G F GS+ +FSC++ +VL+G+K + C E W + +
Sbjct: 446 CPDPGEPENG-----KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHR 500
Query: 423 PTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCE------------EGFELH-G 469
P C+ C + Q P G + P ++ + C + E F+L G
Sbjct: 501 PVCKVKTCGSNLQGPSGTFTSPNFPF-QYDSNAQCVWVITAVNTNKVIQINFEEFDLEIG 559
Query: 470 STQLECTSQGQWTEEVPSCQVVKCSSL----------------------AVPGKINM--- 504
L G+ + QV+ S + +V K+N
Sbjct: 560 YDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEI 619
Query: 505 ---SCS--GEPVFG----------TVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEA 549
SC G P++G V +F C G+ L G + C WS +P C
Sbjct: 620 EKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIF 679
Query: 550 PTESNIPLVAG 560
P SN G
Sbjct: 680 PCLSNFTAPMG 690
Score = 50.4 bits (119), Expect = 5e-06
Identities = 40/154 (25%), Positives = 56/154 (36%), Gaps = 11/154 (7%)
Query: 163 CKCDPGFSGLKCEQI----VNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSS 218
C+ D +SG I +C P HGS + F S C +G+L
Sbjct: 3291 CQADGTWSGSSPHCIEPTQTSCENPGVPRHGS---QNNTFGFQVGSVVQFHCKKGHLLQG 3347
Query: 219 METMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFEL 278
T C+ WS P C C PA+ V P T + C+ GF L
Sbjct: 3348 STTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSH---GYTLIYTCQPGFFL 3404
Query: 279 MGAQSLQ-CTSSGNWDNEKPTCKAVTCRAVRQPQ 311
G + C S W + P C+A + V+ P+
Sbjct: 3405 AGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPR 3438
Score = 48.1 bits (113), Expect = 2e-05
Identities = 69/289 (23%), Positives = 98/289 (33%), Gaps = 69/289 (23%)
Query: 262 FPWNTTCTFDCEEGFELMGAQSLQCTSSGN----WDNEKPTCKAVTCRAVRQPQNGSVRC 317
F +T F C+E + L GA+S+ C W + +P CK TC + Q
Sbjct: 462 FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQ-------- 513
Query: 318 SHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALS----NP 373
P+G FT S NF P Q + Q W I + ++ +
Sbjct: 514 --GPSGTFT---SPNF----------PFQYDSNAQCVWV--ITAVNTNKVIQINFEEFDL 556
Query: 374 ERGY--------------MNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWD 419
E GY L +GSF S + L+ + + G G
Sbjct: 557 EIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESV--GSVGFKV 614
Query: 420 NEKPTCEAVRCDAVHQPPKGLVRCAHSPIGE-FTYKSSCAFSCEEGFELHGSTQLECTSQ 478
N K E C P G+ G+ F+ + F C+ GFEL G + C
Sbjct: 615 NYKEI-EKESCGDPGTPLYGIRE------GDGFSNRDVLRFECQFGFELIGEKSIVCQEN 667
Query: 479 GQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLN 527
QW+ +P C S+ P GTV PEG+ N
Sbjct: 668 NQWSANIPICIFPCLSNFTAP------------MGTVLSPDYPEGYGNN 704
Score = 46.6 bits (109), Expect = 7e-05
Identities = 64/268 (23%), Positives = 104/268 (38%), Gaps = 32/268 (11%)
Query: 184 ESPEHGSLVCSHPLG-NFSYNSSCSISCDRGYLPS-SMETMQC-MSSGE--WSAPIPACN 238
E P+ G + + G NF SS S+ C+ G++ + ET+ C + G+ WS IP C
Sbjct: 793 ECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCG 852
Query: 239 VVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCT-----SSGNWD 293
C + +G + +PG +P + +CE E S++ T + N+D
Sbjct: 853 -APCGGHFSAPSGVI---LSPG-WPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYD 907
Query: 294 NEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQG 353
+ + P GS + P +F F SS NF ++L
Sbjct: 908 ----VLEVHDGPNLLSPLLGSYNGTQVP--QFLFSSS-NFI----YLLFTTDNSRSNNGF 956
Query: 354 QWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCG 413
+ + + C P G F GS+ FSC+ G+ L + L C
Sbjct: 957 KIHYESVTVNTYSCLDPGIPVHG-----RRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCE 1011
Query: 414 PTGEWDNEKPTCEAVRCDAVHQPPKGLV 441
W + PTC+A+ C + P G +
Sbjct: 1012 KNHWWSHPLPTCDAL-CGGDVRGPSGTI 1038
Score = 45.1 bits (105), Expect = 2e-04
Identities = 101/460 (21%), Positives = 145/460 (31%), Gaps = 118/460 (25%)
Query: 180 CTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE----WSAPIP 235
C PE+G + S +FS S+ SCD Y+ +++ C E WS P
Sbjct: 446 CPDPGEPENGKRIGS----DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRP 501
Query: 236 ACNVVECDAVTNPANGFVECFQNPGSFPWNTTCT------------------FDCEEGFE 277
C V C + +G P + N C FD E G++
Sbjct: 502 VCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYD 561
Query: 278 L------------------------------MGAQ---SLQCTSSGNWDNEKPTCKAVTC 304
M +Q LQ S K K +
Sbjct: 562 TLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEK 621
Query: 305 RAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEA 364
+ P G+ F+ + F C+ GF L G + C QW+ IP+C
Sbjct: 622 ESCGDP--GTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC-I 678
Query: 365 FQC---------TALS-NPERGY---MNC---LPSASGSFRYGSSCEFSCEQGFVLKGSK 408
F C T LS + GY +NC + S GS + S +F E F K
Sbjct: 679 FPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVK 738
Query: 409 RLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELH 468
D + P + + P L +H EF S + GF +
Sbjct: 739 ----------DGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMS---GRGFNIT 785
Query: 469 GST--QLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPV-FGTVCKFACPEGW- 524
+T EC G +P IN G+ G+ C EG+
Sbjct: 786 YNTFGHNECPDPG-----IP---------------INARRFGDNFQLGSSISVICEEGFI 825
Query: 525 TLNGSAARTC---GATGHWSGLLPTCEAPTESNIPLVAGL 561
G+ TC WSGL+P C AP + +G+
Sbjct: 826 KTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGV 865
Score = 43.1 bits (100), Expect = 7e-04
Identities = 49/224 (21%), Positives = 76/224 (33%), Gaps = 63/224 (28%)
Query: 388 FRYGSSCEFSCEQGFVLKGSKRLQC--GPTGE--WDNEKPTCEAVRCDAVHQPPKGLVRC 443
++ GS+ + C+ G+VL+G L C G G W+ P+C A C + +G V
Sbjct: 1677 YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAP-CGSRSTGSEGTVLS 1735
Query: 444 AHSP---------------------IGEFTYKSSCAFSCEEGFE--------------LH 468
+ P G+F + + E ++ H
Sbjct: 1736 PNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSH 1795
Query: 469 GSTQLECTSQGQWT------------------EEVPSCQVVKCSSLAVPGKINMSCSGEP 510
L +S Q T + VP +CSS+ P + E
Sbjct: 1796 SGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEP-RFGRRIGNEF 1854
Query: 511 VFGTVCKFACPEGWTLNGSAARTC----GATGHWSGLLPTCEAP 550
G+ F C G+ L+GS A C + W+ LPTC P
Sbjct: 1855 AVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVP 1898
Score = 43.1 bits (100), Expect = 7e-04
Identities = 60/292 (20%), Positives = 100/292 (34%), Gaps = 68/292 (23%)
Query: 234 IPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQC----TSS 289
+P + +C +V P G + F ++ FDC G+ L G+ +++C S
Sbjct: 1830 VPRTSSTQCSSVPEPRFGR----RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSL 1885
Query: 290 GNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCN----FTCEEGFMLQGPA 345
W++ PTC V C + + G++ SP + ++ N T EG +Q
Sbjct: 1886 AQWNDSLPTC-IVPCGGILTKRKGTIL---SPGYPEPYDNNLNCVWKITVPEGAGIQVQV 1941
Query: 346 QVECTTQGQW---------TQQIPVCEAFQCTAL-----SNPERGYMNCLPSASGS---- 387
V T+ W P ++ T + S Y+N S S
Sbjct: 1942 -VSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGF 2000
Query: 388 ---------------------------FRYGSSCEFSCEQGFVLKGSKRLQC--GPTGEW 418
+ G F C+QG+ L+G + C GP W
Sbjct: 2001 HLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRW 2060
Query: 419 DNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCE--EGFELH 468
+ P C A +C G++ P G + C ++ GF +H
Sbjct: 2061 NYPIPICLA-QCGGAMSDFSGVILSPGFP-GNYPSSLDCTWTINLPIGFGVH 2110
Score = 43.1 bits (100), Expect = 7e-04
Identities = 96/448 (21%), Positives = 148/448 (33%), Gaps = 100/448 (22%)
Query: 180 CTALESPEHGSLVCSHPLGN-FSYNSSCSISCDRGYLPSSMETMQCM----SSGEWSAPI 234
C+++ P G + GN F+ SS C+ GY+ ++C S +W+ +
Sbjct: 1838 CSSVPEPRFGRRI-----GNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSL 1892
Query: 235 PACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCE--EGFELMGAQSLQCTSSGNW 292
P C +V C + G + P + N C + EG + Q + + NW
Sbjct: 1893 PTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQ-VQVVSFATEHNW 1950
Query: 293 D---------NEKPTCKAVTCRAVRQPQNGSVR---------CSHSPAG---EFTF--KS 329
D N P + + + N + S S AG E+T
Sbjct: 1951 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 2010
Query: 330 SC----------------------NFTCEEGFMLQGPAQVECTTQG--QWTQQIPVCEAF 365
SC +F C++G+ LQG + + C +W IP+
Sbjct: 2011 SCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPI---- 2066
Query: 366 QCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTC 425
CL G+ S S GF L C W P
Sbjct: 2067 --------------CLAQCGGAMSDFSGVILS--PGFPGNYPSSLDC----TWTINLPIG 2106
Query: 426 EAVRCDAVHQPPKGL-----VRCAHSP----IGEFTYKS--SCAFSCEEGFELHGSTQLE 474
V V+ + + VR S IG + S FS L+ +
Sbjct: 2107 FGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYS 2166
Query: 475 CTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTC 534
QG + + Q+ C P + + G F C G+TL G++A TC
Sbjct: 2167 QNKQG-FHIVYQAYQLQSCPDPR-PFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTC 2224
Query: 535 --GATGHWSGLLPTCEAPTESNIPLVAG 560
G + +W+ LP CEA NI + G
Sbjct: 2225 LHGVSRNWNHPLPRCEALCGGNITAMNG 2252
Score = 42.0 bits (97), Expect = 0.002
Identities = 52/232 (22%), Positives = 83/232 (35%), Gaps = 59/232 (25%)
Query: 189 GSLVCSHPLG-NFSYNSSCSISCDRGYLPSSMETMQCMSSGE----WSAPIPACNVVECD 243
G+++ LG ++ S+ + CD GY+ T+ C+ + W+ +P+C+ C
Sbjct: 1665 GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH-APCG 1723
Query: 244 AVTNPANGFVECFQNP----------------------GSFPWNTTCTFDCEEGFE---- 277
+ + + G V P G F + T D E ++
Sbjct: 1724 SRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQ 1783
Query: 278 -------LMGAQSLQC--TSSGN-----WDNEKP-TCKAVTCRAVRQPQNGSVRCSHSP- 321
L G+ S + SSGN + + P T K P+ S +CS P
Sbjct: 1784 QSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPE 1843
Query: 322 -------AGEFTFKSSCNFTCEEGFMLQGPAQVECTT----QGQWTQQIPVC 362
EF SS F C G++L G + C T QW +P C
Sbjct: 1844 PRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1895
Score = 34.7 bits (78), Expect = 0.26
Identities = 22/68 (32%), Positives = 33/68 (48%), Gaps = 7/68 (10%)
Query: 250 NGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTS--SGNWDNEKPTCKAVTCRAV 307
NGFV F T +F+C G+ L+G +L C S NW++ P C+A+ C
Sbjct: 2192 NGFVI----GNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL-CGGN 2246
Query: 308 RQPQNGSV 315
NG++
Sbjct: 2247 ITAMNGTI 2254
Score = 32.7 bits (73), Expect = 1.00
Identities = 20/78 (25%), Positives = 31/78 (39%), Gaps = 6/78 (7%)
Query: 388 FRYGSSCEFSCEQGFVLKGSKRLQC----GPTGEWDNEKPTCEAV-RCDAVHQPPKGLVR 442
F G +SC G++L G +L C T WD P C A C + G++
Sbjct: 154 FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIIS 213
Query: 443 CAHSPIGEFTYKSSCAFS 460
P E+ + C ++
Sbjct: 214 SPSFP-NEYHNNADCTWT 230
Score = 30.4 bits (67), Expect = 5.0
Identities = 16/45 (35%), Positives = 22/45 (48%), Gaps = 4/45 (8%)
Query: 513 GTVCKFACPEGWTLNGSAARTC--GATGH--WSGLLPTCEAPTES 553
G+ + C G+ L G + TC G G W+ LP+C AP S
Sbjct: 1680 GSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGS 1724
Score = 30.0 bits (66), Expect = 6.5
Identities = 13/38 (34%), Positives = 17/38 (44%), Gaps = 3/38 (7%)
Query: 267 TCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKA 301
T F C+ G+EL G + + C N W P C A
Sbjct: 1509 TVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1546
Score = 29.6 bits (65), Expect = 8.5
Identities = 17/58 (29%), Positives = 25/58 (43%), Gaps = 9/58 (15%)
Query: 436 PPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLEC----TSQGQWTEEVPSCQ 489
PPKG++ +G+ +SC G+ L G QL C + W VP C+
Sbjct: 144 PPKGVLYGTRFDVGD-----KIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 196
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 206 bits (525), Expect = 4e-53
Identities = 122/401 (30%), Positives = 183/401 (45%), Gaps = 21/401 (5%)
Query: 163 CKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGN-FSYNSSCSISCDRGYLPSSMET 221
C+ D +SG Q+ +C + GS + GN F++N + SC+ GYL
Sbjct: 2688 CQQDHNWSG----QLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTK 2743
Query: 222 MQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGA 281
QC ++ +WS P P C VV C PAN E G+F + T +DC G+ L G+
Sbjct: 2744 AQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGS 2803
Query: 282 QSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGE-FTFKSSCNFTCEEGFM 340
L C +G WD P C + C P N + +GE +TF S+ +++C
Sbjct: 2804 SVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVL------SGEKYTFGSTVHYSCTGKRS 2857
Query: 341 LQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQ 400
L G + C G W+ P C +P G +FR S+ ++C+
Sbjct: 2858 LLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDP--GTPGHGSRQESNFRTKSTVRYACDT 2915
Query: 401 GFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFS 460
G++L GS+ C G W +P C+AV+C G V I T+ SS +S
Sbjct: 2916 GYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKV----FRIDGTTFSSSVIYS 2971
Query: 461 CEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFAC 520
C EG+ L G + +CT+ G W+ +P+C ++ C +P + + V G + C
Sbjct: 2972 CMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPAN-GLRYGDDYVVGQNVSYMC 3030
Query: 521 PEGWT--LNGSAARTCGATGHWSGLLPTCEAPTESNIPLVA 559
G+T LNGS RTC G WSG++PTC A T P ++
Sbjct: 3031 QPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQIS 3071
Score = 167 bits (423), Expect = 3e-41
Identities = 118/430 (27%), Positives = 173/430 (40%), Gaps = 77/430 (17%)
Query: 180 CTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSG----EWSAPIP 235
C+ ESP HG ++ S G NS +CDRG+ + C S W AP+P
Sbjct: 2465 CSTPESPPHGYII-SQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVP 2521
Query: 236 ACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQ--SLQCTSSGNWD 293
AC + C P NG + + T T+ C +G+ L + + C S G W
Sbjct: 2522 ACQAISCGIPKAPTNGGILTTD----YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWS 2577
Query: 294 NEK--PTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTT 351
N P C ++C + P NG+ + + G S+ FTC+ GFML G A EC +
Sbjct: 2578 NHNKTPRCVVISCGELPTPPNGNKIGTQTSYG-----STAIFTCDLGFMLVGSAVRECLS 2632
Query: 352 QGQWTQQIPVCEAFQC--------------------TALSNPERGYM------------- 378
G W++ C A C T + G+
Sbjct: 2633 SGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDH 2692
Query: 379 -------NCLPSASG-------------SFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEW 418
+C+P + G F + FSC G++++G + QC +W
Sbjct: 2693 NWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQW 2752
Query: 419 DNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQ 478
+ P C+ V C P R + G FTY + + C G+ L GS+ L C
Sbjct: 2753 SHPPPMCKVVNCSDPGIPANS-KRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN 2811
Query: 479 GQWTEEVPSCQVVKCSSLAVPGKINMSCSGEP-VFGTVCKFACPEGWTLNGSAARTCGAT 537
GQW + +P C ++ C VP N SGE FG+ ++C +L G ++RTC
Sbjct: 2812 GQWDKPLPECIMIDCGHPGVPP--NAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLN 2869
Query: 538 GHWSGLLPTC 547
GHWSG P C
Sbjct: 2870 GHWSGSQPHC 2879
Score = 164 bits (415), Expect = 2e-40
Identities = 120/434 (27%), Positives = 174/434 (40%), Gaps = 42/434 (9%)
Query: 140 TAACTNTSCSGHGECVETINNYTCK------CDPGFSGLKCEQIVNCTALES-----PEH 188
T C + GHG E+ N+ K CD G+ L + C A S PE
Sbjct: 2884 TGTCGDPGTPGHGSRQES--NFRTKSTVRYACDTGYI-LHGSEERTCLANGSWTGRQPEC 2940
Query: 189 GSLVCSHP----------LGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACN 238
++ C +P + +++SS SC GY+ S QC ++G WS +P C
Sbjct: 2941 KAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCT 3000
Query: 239 VVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGF--ELMGAQSLQCTSSGNWDNEK 296
++ C PANG + + ++ C+ G+ EL G++ CT +G W
Sbjct: 3001 IISCGDPGIPANGL----RYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVM 3056
Query: 297 PTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWT 356
PTC+AVTC Q NG + ++ F + S ++ C G+ L PA + C G W+
Sbjct: 3057 PTCRAVTCPTPPQISNGRLEGTN-----FDWGFSISYICSPGYELSFPAVLTCVGNGTWS 3111
Query: 357 QQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTG 416
++P C C P +G SF Y S FSC F+L GS C G
Sbjct: 3112 GEVPQCLPKFCGDPGIPAQG-----KREGKSFIYQSEVSFSCNFPFILVGSSTRICQADG 3166
Query: 417 EWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECT 476
W P C + P ++ G F S F C++G L GST C
Sbjct: 3167 TWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFG-FQVGSVVQFHCKKGHLLQGSTTRTCL 3225
Query: 477 SQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTL-NGSAARTCG 535
W+ P C C P N+ P G + C G+ L G+ R C
Sbjct: 3226 PDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCR 3285
Query: 536 ATGHWSGLLPTCEA 549
+ W+G +P CEA
Sbjct: 3286 SDNTWTGKVPICEA 3299
Score = 159 bits (402), Expect = 7e-39
Identities = 107/385 (27%), Positives = 159/385 (41%), Gaps = 37/385 (9%)
Query: 186 PEHGSLVCSHPL---------GNFSYNSSCSISCD--RGYLPSSMETMQCMSSGEWSAPI 234
PE + C HP +++ S+ SC R L S T C +G WS
Sbjct: 2819 PECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRT--CQLNGHWSGSQ 2876
Query: 235 PACN---VVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN 291
P C+ C P +G + +F +T + C+ G+ L G++ C ++G+
Sbjct: 2877 PHCSGDATGTCGDPGTPGHGS----RQESNFRTKSTVRYACDTGYILHGSEERTCLANGS 2932
Query: 292 WDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTT 351
W +P CKAV C NG V TF SS ++C EG++L GP+ +CT
Sbjct: 2933 WTGRQPECKAVQCGNPGTTANGKVFRIDGT----TFSSSVIYSCMEGYILSGPSVRQCTA 2988
Query: 352 QGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFV--LKGSKR 409
G W+ +P C C P G + G + + C+ G+ L GS+
Sbjct: 2989 NGTWSGTLPNCTIISCGDPGIPANGLRY-----GDDYVVGQNVSYMCQPGYTMELNGSRI 3043
Query: 410 LQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHG 469
C G W PTC AV C Q G + + F + S ++ C G+EL
Sbjct: 3044 RTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN-----FDWGFSISYICSPGYELSF 3098
Query: 470 STQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGS 529
L C G W+ EVP C C +P + ++ + F+C + L GS
Sbjct: 3099 PAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSF-IYQSEVSFSCNFPFILVGS 3157
Query: 530 AARTCGATGHWSGLLPTCEAPTESN 554
+ R C A G WSG P C PT+++
Sbjct: 3158 STRICQADGTWSGSSPHCIEPTQTS 3182
Score = 78.6 bits (192), Expect = 2e-14
Identities = 54/194 (27%), Positives = 81/194 (41%), Gaps = 18/194 (9%)
Query: 364 AFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTG----EWD 419
AF C+ +P GY + S +G + S ++C++GF L G C + WD
Sbjct: 2462 AFYCSTPESPPHGY---IISQTGG-QLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWD 2517
Query: 420 NEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGS--TQLECTS 477
P C+A+ C P G + +G + + C +G+ L T C S
Sbjct: 2518 APVPACQAISCGIPKAPTNGGILTTDYLVG-----TRVTYFCNDGYRLSSKELTTAVCQS 2572
Query: 478 QGQWTE--EVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCG 535
G W+ + P C V+ C L P N + +G+ F C G+ L GSA R C
Sbjct: 2573 DGTWSNHNKTPRCVVISCGELPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRECL 2631
Query: 536 ATGHWSGLLPTCEA 549
++G WS C A
Sbjct: 2632 SSGLWSESETRCLA 2645
Score = 75.5 bits (184), Expect = 1e-13
Identities = 45/176 (25%), Positives = 72/176 (40%), Gaps = 5/176 (2%)
Query: 199 NFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQN 258
+F Y S S SC+ ++ T C + G WS P C + NP N
Sbjct: 3137 SFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNN 3196
Query: 259 PGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCS 318
F + F C++G L G+ + C W +P C +C+ P + +V
Sbjct: 3197 TFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGM 3256
Query: 319 HSPAGEFTFKSSCNFTCEEGFMLQGPAQVE-CTTQGQWTQQIPVCEAFQCTALSNP 373
P+ +T +TC+ GF L G + C + WT ++P+CEA + +P
Sbjct: 3257 DLPSHGYTLI----YTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDP 3308
Score = 57.0 bits (136), Expect = 5e-08
Identities = 103/471 (21%), Positives = 165/471 (35%), Gaps = 115/471 (24%)
Query: 144 TNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYN 203
+N H E V T+N Y+C DPG P HG H +FS
Sbjct: 888 SNNGFKIHYESV-TVNTYSC-LDPGI----------------PVHGRRY-GH---DFSIG 925
Query: 204 SSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPAN-----GFVECFQN 258
S+ S SCD GY S E + C + WS P+P C+ + V P+ G+ E + N
Sbjct: 926 STVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPN 985
Query: 259 PGSFPWNTTC-----------TFDCEEGFE----------------LMGAQSLQCTSSGN 291
+ W TF E+ + L G+ ++G
Sbjct: 986 SLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGL 1045
Query: 292 WDNEKPTCKAVT--------------------CRAVRQPQNGSVRCSHSPAGEFTFKSSC 331
+ N + + ++ C PQ GS F +
Sbjct: 1046 YGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGS-----RIGFNFGIGDTL 1100
Query: 332 NFTCEEGFMLQGPAQVECTTQGQ--WTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFR 389
F+C G+ L+G +++ C G+ W+ +P C A +C A + G + P+ ++
Sbjct: 1101 TFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA-ECGASATNNEGIL-LSPNYPLNYE 1158
Query: 390 YGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIG 449
C +S + G+ N + V + G + H +G
Sbjct: 1159 NNHECIYSIQV-------------QAGKGINISARTFHLAQGDVLKIYDGKDKTTHL-LG 1204
Query: 450 EFTYKSSCAFSCEEGFELHGSTQ---LECTSQGQWTEE-----VPSCQVVKCSSLAVPGK 501
FT S G L ++ LE S + T+E S ++ C +P +
Sbjct: 1205 AFTGASM------RGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIP-Q 1257
Query: 502 INMSCSGEPVF-GTVCKFACPEGWTLNGSAARTC--GATGHWSGLLPTCEA 549
S + F G+ + C G+TL+GS+ C G W LP+C A
Sbjct: 1258 FGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIA 1308
Score = 52.4 bits (124), Expect = 1e-06
Identities = 65/276 (23%), Positives = 107/276 (38%), Gaps = 40/276 (14%)
Query: 266 TTCTFDCEEGFELMGAQSLQCTSSGN----WDNEKPTCKAVTCRAVRQPQNGSVRCSHSP 321
+T T+ C+ G+ L G +L C + W+ P+C A C + G+V + P
Sbjct: 1617 STVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA-PCGSRSTGSEGTVLSPNYP 1675
Query: 322 AGEFTFKSSCNFTCE--EGFMLQGPAQVECTTQGQWTQQI--PVCEAFQCTALSNPERGY 377
++ +C ++ + F++ G T+ + P ++ ++LS G
Sbjct: 1676 KN-YSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSG- 1733
Query: 378 MNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPP 437
LP +SG+ + F+ KG + P + +C +V +P
Sbjct: 1734 -ESLPLSSGN---QITIRFTSVGPITAKGFHFVY--------QAVPRTSSTQCSSVPEPR 1781
Query: 438 KGLVRCAHSPIG-EFTYKSSCAFSCEEGFELHGSTQLEC----TSQGQWTEEVPSCQVVK 492
G IG EF SS F C G+ LHGS + C S QW + +P+C +V
Sbjct: 1782 FG------RRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC-IVP 1834
Query: 493 CSSLAVPGKINMSCSGEPV-----FGTVCKFACPEG 523
C + K + G P V K PEG
Sbjct: 1835 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEG 1870
Score = 51.2 bits (121), Expect = 3e-06
Identities = 57/251 (22%), Positives = 87/251 (34%), Gaps = 63/251 (25%)
Query: 367 CTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGE----WDNEK 422
C PE G F GS+ +FSC++ +VL+G+K + C E W + +
Sbjct: 382 CPDPGEPENG-----KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHR 436
Query: 423 PTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCE------------EGFELH-G 469
P C+ C + Q P G + P ++ + C + E F+L G
Sbjct: 437 PVCKVKTCGSNLQGPSGTFTSPNFPF-QYDSNAQCVWVITAVNTNKVIQINFEEFDLEIG 495
Query: 470 STQLECTSQGQWTEEVPSCQVVKCSSL----------------------AVPGKINM--- 504
L G+ + QV+ S + +V K+N
Sbjct: 496 YDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEI 555
Query: 505 ---SCS--GEPVFG----------TVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEA 549
SC G P++G V +F C G+ L G + C WS +P C
Sbjct: 556 EKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIF 615
Query: 550 PTESNIPLVAG 560
P SN G
Sbjct: 616 PCLSNFTAPMG 626
Score = 50.4 bits (119), Expect = 5e-06
Identities = 40/154 (25%), Positives = 56/154 (36%), Gaps = 11/154 (7%)
Query: 163 CKCDPGFSGLKCEQI----VNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSS 218
C+ D +SG I +C P HGS + F S C +G+L
Sbjct: 3162 CQADGTWSGSSPHCIEPTQTSCENPGVPRHGS---QNNTFGFQVGSVVQFHCKKGHLLQG 3218
Query: 219 METMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFEL 278
T C+ WS P C C PA+ V P T + C+ GF L
Sbjct: 3219 STTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSH---GYTLIYTCQPGFFL 3275
Query: 279 MGAQSLQ-CTSSGNWDNEKPTCKAVTCRAVRQPQ 311
G + C S W + P C+A + V+ P+
Sbjct: 3276 AGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPR 3309
Score = 48.1 bits (113), Expect = 2e-05
Identities = 69/289 (23%), Positives = 98/289 (33%), Gaps = 69/289 (23%)
Query: 262 FPWNTTCTFDCEEGFELMGAQSLQCTSSGN----WDNEKPTCKAVTCRAVRQPQNGSVRC 317
F +T F C+E + L GA+S+ C W + +P CK TC + Q
Sbjct: 398 FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQ-------- 449
Query: 318 SHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALS----NP 373
P+G FT S NF P Q + Q W I + ++ +
Sbjct: 450 --GPSGTFT---SPNF----------PFQYDSNAQCVWV--ITAVNTNKVIQINFEEFDL 492
Query: 374 ERGY--------------MNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWD 419
E GY L +GSF S + L+ + + G G
Sbjct: 493 EIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESV--GSVGFKV 550
Query: 420 NEKPTCEAVRCDAVHQPPKGLVRCAHSPIGE-FTYKSSCAFSCEEGFELHGSTQLECTSQ 478
N K E C P G+ G+ F+ + F C+ GFEL G + C
Sbjct: 551 NYKEI-EKESCGDPGTPLYGIRE------GDGFSNRDVLRFECQFGFELIGEKSIVCQEN 603
Query: 479 GQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLN 527
QW+ +P C S+ P GTV PEG+ N
Sbjct: 604 NQWSANIPICIFPCLSNFTAP------------MGTVLSPDYPEGYGNN 640
Score = 46.6 bits (109), Expect = 7e-05
Identities = 64/268 (23%), Positives = 104/268 (38%), Gaps = 32/268 (11%)
Query: 184 ESPEHGSLVCSHPLG-NFSYNSSCSISCDRGYLPS-SMETMQC-MSSGE--WSAPIPACN 238
E P+ G + + G NF SS S+ C+ G++ + ET+ C + G+ WS IP C
Sbjct: 729 ECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCG 788
Query: 239 VVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCT-----SSGNWD 293
C + +G + +PG +P + +CE E S++ T + N+D
Sbjct: 789 -APCGGHFSAPSGVI---LSPG-WPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYD 843
Query: 294 NEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQG 353
+ + P GS + P +F F SS NF ++L
Sbjct: 844 ----VLEVHDGPNLLSPLLGSYNGTQVP--QFLFSSS-NFI----YLLFTTDNSRSNNGF 892
Query: 354 QWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCG 413
+ + + C P G F GS+ FSC+ G+ L + L C
Sbjct: 893 KIHYESVTVNTYSCLDPGIPVHG-----RRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCE 947
Query: 414 PTGEWDNEKPTCEAVRCDAVHQPPKGLV 441
W + PTC+A+ C + P G +
Sbjct: 948 KNHWWSHPLPTCDAL-CGGDVRGPSGTI 974
Score = 45.1 bits (105), Expect = 2e-04
Identities = 101/460 (21%), Positives = 145/460 (31%), Gaps = 118/460 (25%)
Query: 180 CTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE----WSAPIP 235
C PE+G + S +FS S+ SCD Y+ +++ C E WS P
Sbjct: 382 CPDPGEPENGKRIGS----DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRP 437
Query: 236 ACNVVECDAVTNPANGFVECFQNPGSFPWNTTCT------------------FDCEEGFE 277
C V C + +G P + N C FD E G++
Sbjct: 438 VCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYD 497
Query: 278 L------------------------------MGAQ---SLQCTSSGNWDNEKPTCKAVTC 304
M +Q LQ S K K +
Sbjct: 498 TLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEK 557
Query: 305 RAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEA 364
+ P G+ F+ + F C+ GF L G + C QW+ IP+C
Sbjct: 558 ESCGDP--GTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC-I 614
Query: 365 FQC---------TALS-NPERGY---MNC---LPSASGSFRYGSSCEFSCEQGFVLKGSK 408
F C T LS + GY +NC + S GS + S +F E F K
Sbjct: 615 FPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVK 674
Query: 409 RLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELH 468
D + P + + P L +H EF S + GF +
Sbjct: 675 ----------DGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMS---GRGFNIT 721
Query: 469 GST--QLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPV-FGTVCKFACPEGW- 524
+T EC G +P IN G+ G+ C EG+
Sbjct: 722 YNTFGHNECPDPG-----IP---------------INARRFGDNFQLGSSISVICEEGFI 761
Query: 525 TLNGSAARTC---GATGHWSGLLPTCEAPTESNIPLVAGL 561
G+ TC WSGL+P C AP + +G+
Sbjct: 762 KTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGV 801
Score = 43.1 bits (100), Expect = 7e-04
Identities = 49/224 (21%), Positives = 76/224 (33%), Gaps = 63/224 (28%)
Query: 388 FRYGSSCEFSCEQGFVLKGSKRLQC--GPTGE--WDNEKPTCEAVRCDAVHQPPKGLVRC 443
++ GS+ + C+ G+VL+G L C G G W+ P+C A C + +G V
Sbjct: 1613 YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAP-CGSRSTGSEGTVLS 1671
Query: 444 AHSP---------------------IGEFTYKSSCAFSCEEGFE--------------LH 468
+ P G+F + + E ++ H
Sbjct: 1672 PNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSH 1731
Query: 469 GSTQLECTSQGQWT------------------EEVPSCQVVKCSSLAVPGKINMSCSGEP 510
L +S Q T + VP +CSS+ P + E
Sbjct: 1732 SGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEP-RFGRRIGNEF 1790
Query: 511 VFGTVCKFACPEGWTLNGSAARTC----GATGHWSGLLPTCEAP 550
G+ F C G+ L+GS A C + W+ LPTC P
Sbjct: 1791 AVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVP 1834
Score = 43.1 bits (100), Expect = 7e-04
Identities = 60/292 (20%), Positives = 100/292 (34%), Gaps = 68/292 (23%)
Query: 234 IPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQC----TSS 289
+P + +C +V P G + F ++ FDC G+ L G+ +++C S
Sbjct: 1766 VPRTSSTQCSSVPEPRFGR----RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSL 1821
Query: 290 GNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCN----FTCEEGFMLQGPA 345
W++ PTC V C + + G++ SP + ++ N T EG +Q
Sbjct: 1822 AQWNDSLPTC-IVPCGGILTKRKGTIL---SPGYPEPYDNNLNCVWKITVPEGAGIQVQV 1877
Query: 346 QVECTTQGQW---------TQQIPVCEAFQCTAL-----SNPERGYMNCLPSASGS---- 387
V T+ W P ++ T + S Y+N S S
Sbjct: 1878 -VSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGF 1936
Query: 388 ---------------------------FRYGSSCEFSCEQGFVLKGSKRLQC--GPTGEW 418
+ G F C+QG+ L+G + C GP W
Sbjct: 1937 HLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRW 1996
Query: 419 DNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCE--EGFELH 468
+ P C A +C G++ P G + C ++ GF +H
Sbjct: 1997 NYPIPICLA-QCGGAMSDFSGVILSPGFP-GNYPSSLDCTWTINLPIGFGVH 2046
Score = 43.1 bits (100), Expect = 7e-04
Identities = 96/448 (21%), Positives = 148/448 (33%), Gaps = 100/448 (22%)
Query: 180 CTALESPEHGSLVCSHPLGN-FSYNSSCSISCDRGYLPSSMETMQCM----SSGEWSAPI 234
C+++ P G + GN F+ SS C+ GY+ ++C S +W+ +
Sbjct: 1774 CSSVPEPRFGRRI-----GNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSL 1828
Query: 235 PACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCE--EGFELMGAQSLQCTSSGNW 292
P C +V C + G + P + N C + EG + Q + + NW
Sbjct: 1829 PTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQ-VQVVSFATEHNW 1886
Query: 293 D---------NEKPTCKAVTCRAVRQPQNGSVR---------CSHSPAG---EFTF--KS 329
D N P + + + N + S S AG E+T
Sbjct: 1887 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 1946
Query: 330 SC----------------------NFTCEEGFMLQGPAQVECTTQG--QWTQQIPVCEAF 365
SC +F C++G+ LQG + + C +W IP+
Sbjct: 1947 SCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPI---- 2002
Query: 366 QCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTC 425
CL G+ S S GF L C W P
Sbjct: 2003 --------------CLAQCGGAMSDFSGVILS--PGFPGNYPSSLDC----TWTINLPIG 2042
Query: 426 EAVRCDAVHQPPKGL-----VRCAHSP----IGEFTYKS--SCAFSCEEGFELHGSTQLE 474
V V+ + + VR S IG + S FS L+ +
Sbjct: 2043 FGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYS 2102
Query: 475 CTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTC 534
QG + + Q+ C P + + G F C G+TL G++A TC
Sbjct: 2103 QNKQG-FHIVYQAYQLQSCPDPR-PFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTC 2160
Query: 535 --GATGHWSGLLPTCEAPTESNIPLVAG 560
G + +W+ LP CEA NI + G
Sbjct: 2161 LHGVSRNWNHPLPRCEALCGGNITAMNG 2188
Score = 42.0 bits (97), Expect = 0.002
Identities = 52/232 (22%), Positives = 83/232 (35%), Gaps = 59/232 (25%)
Query: 189 GSLVCSHPLG-NFSYNSSCSISCDRGYLPSSMETMQCMSSGE----WSAPIPACNVVECD 243
G+++ LG ++ S+ + CD GY+ T+ C+ + W+ +P+C+ C
Sbjct: 1601 GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH-APCG 1659
Query: 244 AVTNPANGFVECFQNP----------------------GSFPWNTTCTFDCEEGFE---- 277
+ + + G V P G F + T D E ++
Sbjct: 1660 SRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQ 1719
Query: 278 -------LMGAQSLQC--TSSGN-----WDNEKP-TCKAVTCRAVRQPQNGSVRCSHSP- 321
L G+ S + SSGN + + P T K P+ S +CS P
Sbjct: 1720 QSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPE 1779
Query: 322 -------AGEFTFKSSCNFTCEEGFMLQGPAQVECTT----QGQWTQQIPVC 362
EF SS F C G++L G + C T QW +P C
Sbjct: 1780 PRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1831
Score = 34.7 bits (78), Expect = 0.26
Identities = 22/68 (32%), Positives = 33/68 (48%), Gaps = 7/68 (10%)
Query: 250 NGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTS--SGNWDNEKPTCKAVTCRAV 307
NGFV F T +F+C G+ L+G +L C S NW++ P C+A+ C
Sbjct: 2128 NGFVI----GNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL-CGGN 2182
Query: 308 RQPQNGSV 315
NG++
Sbjct: 2183 ITAMNGTI 2190
Score = 32.7 bits (73), Expect = 1.00
Identities = 20/78 (25%), Positives = 31/78 (39%), Gaps = 6/78 (7%)
Query: 388 FRYGSSCEFSCEQGFVLKGSKRLQC----GPTGEWDNEKPTCEAV-RCDAVHQPPKGLVR 442
F G +SC G++L G +L C T WD P C A C + G++
Sbjct: 194 FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIIS 253
Query: 443 CAHSPIGEFTYKSSCAFS 460
P E+ + C ++
Sbjct: 254 SPSFP-NEYHNNADCTWT 270
Score = 30.4 bits (67), Expect = 5.0
Identities = 16/45 (35%), Positives = 22/45 (48%), Gaps = 4/45 (8%)
Query: 513 GTVCKFACPEGWTLNGSAARTC--GATGH--WSGLLPTCEAPTES 553
G+ + C G+ L G + TC G G W+ LP+C AP S
Sbjct: 1616 GSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGS 1660
Score = 30.0 bits (66), Expect = 6.5
Identities = 13/38 (34%), Positives = 17/38 (44%), Gaps = 3/38 (7%)
Query: 267 TCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKA 301
T F C+ G+EL G + + C N W P C A
Sbjct: 1445 TVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1482
Score = 29.6 bits (65), Expect = 8.5
Identities = 17/58 (29%), Positives = 25/58 (43%), Gaps = 9/58 (15%)
Query: 436 PPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLEC----TSQGQWTEEVPSCQ 489
PPKG++ +G+ +SC G+ L G QL C + W VP C+
Sbjct: 184 PPKGVLYGTRFDVGD-----KIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 236
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 206 bits (525), Expect = 4e-53
Identities = 122/401 (30%), Positives = 183/401 (45%), Gaps = 21/401 (5%)
Query: 163 CKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGN-FSYNSSCSISCDRGYLPSSMET 221
C+ D +SG Q+ +C + GS + GN F++N + SC+ GYL
Sbjct: 2857 CQQDHNWSG----QLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTK 2912
Query: 222 MQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGA 281
QC ++ +WS P P C VV C PAN E G+F + T +DC G+ L G+
Sbjct: 2913 AQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGS 2972
Query: 282 QSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGE-FTFKSSCNFTCEEGFM 340
L C +G WD P C + C P N + +GE +TF S+ +++C
Sbjct: 2973 SVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVL------SGEKYTFGSTVHYSCTGKRS 3026
Query: 341 LQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQ 400
L G + C G W+ P C +P G +FR S+ ++C+
Sbjct: 3027 LLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDP--GTPGHGSRQESNFRTKSTVRYACDT 3084
Query: 401 GFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFS 460
G++L GS+ C G W +P C+AV+C G V I T+ SS +S
Sbjct: 3085 GYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKV----FRIDGTTFSSSVIYS 3140
Query: 461 CEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFAC 520
C EG+ L G + +CT+ G W+ +P+C ++ C +P + + V G + C
Sbjct: 3141 CMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPAN-GLRYGDDYVVGQNVSYMC 3199
Query: 521 PEGWT--LNGSAARTCGATGHWSGLLPTCEAPTESNIPLVA 559
G+T LNGS RTC G WSG++PTC A T P ++
Sbjct: 3200 QPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQIS 3240
Score = 164 bits (415), Expect = 2e-40
Identities = 120/434 (27%), Positives = 174/434 (40%), Gaps = 42/434 (9%)
Query: 140 TAACTNTSCSGHGECVETINNYTCK------CDPGFSGLKCEQIVNCTALES-----PEH 188
T C + GHG E+ N+ K CD G+ L + C A S PE
Sbjct: 3053 TGTCGDPGTPGHGSRQES--NFRTKSTVRYACDTGYI-LHGSEERTCLANGSWTGRQPEC 3109
Query: 189 GSLVCSHP----------LGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACN 238
++ C +P + +++SS SC GY+ S QC ++G WS +P C
Sbjct: 3110 KAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCT 3169
Query: 239 VVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGF--ELMGAQSLQCTSSGNWDNEK 296
++ C PANG + + ++ C+ G+ EL G++ CT +G W
Sbjct: 3170 IISCGDPGIPANGL----RYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVM 3225
Query: 297 PTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWT 356
PTC+AVTC Q NG + ++ F + S ++ C G+ L PA + C G W+
Sbjct: 3226 PTCRAVTCPTPPQISNGRLEGTN-----FDWGFSISYICSPGYELSFPAVLTCVGNGTWS 3280
Query: 357 QQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTG 416
++P C C P +G SF Y S FSC F+L GS C G
Sbjct: 3281 GEVPQCLPKFCGDPGIPAQG-----KREGKSFIYQSEVSFSCNFPFILVGSSTRICQADG 3335
Query: 417 EWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECT 476
W P C + P ++ G F S F C++G L GST C
Sbjct: 3336 TWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFG-FQVGSVVQFHCKKGHLLQGSTTRTCL 3394
Query: 477 SQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTL-NGSAARTCG 535
W+ P C C P N+ P G + C G+ L G+ R C
Sbjct: 3395 PDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCR 3454
Query: 536 ATGHWSGLLPTCEA 549
+ W+G +P CEA
Sbjct: 3455 SDNTWTGKVPICEA 3468
Score = 160 bits (405), Expect = 3e-39
Identities = 110/380 (28%), Positives = 160/380 (42%), Gaps = 30/380 (7%)
Query: 180 CTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSG----EWSAPIP 235
C+ ESP HG ++ S G NS +CDRG+ + C S W AP+P
Sbjct: 2569 CSTPESPPHGYII-SQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVP 2625
Query: 236 ACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQ--SLQCTSSGNWD 293
AC + C P NG + + T T+ C +G+ L + + C S G W
Sbjct: 2626 ACQAISCGIPKAPTNGGILTTD----YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWS 2681
Query: 294 NEK--PTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTT 351
N P C VTC ++ R + +K+ F+C+ G+ GPA +EC
Sbjct: 2682 NHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLP 2741
Query: 352 QGQWT--QQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKR 409
G W+ + P C+ C L P G N + + + YGS+ F+C+ GF+L GS
Sbjct: 2742 NGTWSWRNERPYCQIISCGELPTPPNG--NKIGTQTS---YGSTAIFTCDLGFMLVGSAV 2796
Query: 410 LQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGE-FTYKSSCAFSCEEGFELH 468
+C +G W + C A C G V IGE + Y+ + + C GF L
Sbjct: 2797 RECLSSGLWSESETRCLAGHCGIPELIVNGQV------IGENYGYRDTVVYQCNPGFRLI 2850
Query: 469 GSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNG 528
GS+ C W+ ++PSC V C P S +G F V F+C G+ + G
Sbjct: 2851 GSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFN-FNDVVTFSCNIGYLMQG 2909
Query: 529 SAARTCGATGHWSGLLPTCE 548
C A WS P C+
Sbjct: 2910 PTKAQCQANRQWSHPPPMCK 2929
Score = 159 bits (402), Expect = 7e-39
Identities = 107/385 (27%), Positives = 159/385 (41%), Gaps = 37/385 (9%)
Query: 186 PEHGSLVCSHPL---------GNFSYNSSCSISCD--RGYLPSSMETMQCMSSGEWSAPI 234
PE + C HP +++ S+ SC R L S T C +G WS
Sbjct: 2988 PECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRT--CQLNGHWSGSQ 3045
Query: 235 PACN---VVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN 291
P C+ C P +G + +F +T + C+ G+ L G++ C ++G+
Sbjct: 3046 PHCSGDATGTCGDPGTPGHGS----RQESNFRTKSTVRYACDTGYILHGSEERTCLANGS 3101
Query: 292 WDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTT 351
W +P CKAV C NG V TF SS ++C EG++L GP+ +CT
Sbjct: 3102 WTGRQPECKAVQCGNPGTTANGKVFRIDGT----TFSSSVIYSCMEGYILSGPSVRQCTA 3157
Query: 352 QGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFV--LKGSKR 409
G W+ +P C C P G + G + + C+ G+ L GS+
Sbjct: 3158 NGTWSGTLPNCTIISCGDPGIPANGLRY-----GDDYVVGQNVSYMCQPGYTMELNGSRI 3212
Query: 410 LQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHG 469
C G W PTC AV C Q G + + F + S ++ C G+EL
Sbjct: 3213 RTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTN-----FDWGFSISYICSPGYELSF 3267
Query: 470 STQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGS 529
L C G W+ EVP C C +P + ++ + F+C + L GS
Sbjct: 3268 PAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSF-IYQSEVSFSCNFPFILVGS 3326
Query: 530 AARTCGATGHWSGLLPTCEAPTESN 554
+ R C A G WSG P C PT+++
Sbjct: 3327 STRICQADGTWSGSSPHCIEPTQTS 3351
Score = 94.4 bits (233), Expect = 3e-19
Identities = 65/234 (27%), Positives = 94/234 (40%), Gaps = 22/234 (9%)
Query: 329 SSCNFTCEEGFMLQGPAQVECTTQGQ----WTQQIPVCEAFQCTALSNPERGYMNCLPSA 384
S + C+ GF L G + C W +P C+A C P G +
Sbjct: 2590 SVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGI-----L 2644
Query: 385 SGSFRYGSSCEFSCEQGFVLKGSKRLQ---CGPTGEWDNEK--PTCEAVRCDAVHQ--PP 437
+ + G+ + C G+ L SK L C G W N P C V C +++
Sbjct: 2645 TTDYLVGTRVTYFCNDGYRLS-SKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILE 2703
Query: 438 KGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWT--EEVPSCQVVKCSS 495
G R + + YK+ FSC+ G+ G +EC G W+ E P CQ++ C
Sbjct: 2704 HGRWRIVNG--SHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGE 2761
Query: 496 LAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEA 549
L P N + +G+ F C G+ L GSA R C ++G WS C A
Sbjct: 2762 LPTPPNGN-KIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLA 2814
Score = 75.5 bits (184), Expect = 1e-13
Identities = 45/176 (25%), Positives = 72/176 (40%), Gaps = 5/176 (2%)
Query: 199 NFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQN 258
+F Y S S SC+ ++ T C + G WS P C + NP N
Sbjct: 3306 SFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNN 3365
Query: 259 PGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCS 318
F + F C++G L G+ + C W +P C +C+ P + +V
Sbjct: 3366 TFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGM 3425
Query: 319 HSPAGEFTFKSSCNFTCEEGFMLQGPAQVE-CTTQGQWTQQIPVCEAFQCTALSNP 373
P+ +T +TC+ GF L G + C + WT ++P+CEA + +P
Sbjct: 3426 DLPSHGYTLI----YTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDP 3477
Score = 57.0 bits (136), Expect = 5e-08
Identities = 103/471 (21%), Positives = 165/471 (35%), Gaps = 115/471 (24%)
Query: 144 TNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYN 203
+N H E V T+N Y+C DPG P HG H +FS
Sbjct: 992 SNNGFKIHYESV-TVNTYSC-LDPGI----------------PVHGRRY-GH---DFSIG 1029
Query: 204 SSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPAN-----GFVECFQN 258
S+ S SCD GY S E + C + WS P+P C+ + V P+ G+ E + N
Sbjct: 1030 STVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPN 1089
Query: 259 PGSFPWNTTC-----------TFDCEEGFE----------------LMGAQSLQCTSSGN 291
+ W TF E+ + L G+ ++G
Sbjct: 1090 SLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGL 1149
Query: 292 WDNEKPTCKAVT--------------------CRAVRQPQNGSVRCSHSPAGEFTFKSSC 331
+ N + + ++ C PQ GS F +
Sbjct: 1150 YGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGS-----RIGFNFGIGDTL 1204
Query: 332 NFTCEEGFMLQGPAQVECTTQGQ--WTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFR 389
F+C G+ L+G +++ C G+ W+ +P C A +C A + G + P+ ++
Sbjct: 1205 TFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVA-ECGASATNNEGIL-LSPNYPLNYE 1262
Query: 390 YGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIG 449
C +S + G+ N + V + G + H +G
Sbjct: 1263 NNHECIYSIQV-------------QAGKGINISARTFHLAQGDVLKIYDGKDKTTHL-LG 1308
Query: 450 EFTYKSSCAFSCEEGFELHGSTQ---LECTSQGQWTEE-----VPSCQVVKCSSLAVPGK 501
FT S G L ++ LE S + T+E S ++ C +P +
Sbjct: 1309 AFTGASM------RGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIP-Q 1361
Query: 502 INMSCSGEPVF-GTVCKFACPEGWTLNGSAARTC--GATGHWSGLLPTCEA 549
S + F G+ + C G+TL+GS+ C G W LP+C A
Sbjct: 1362 FGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIA 1412
Score = 52.4 bits (124), Expect = 1e-06
Identities = 65/276 (23%), Positives = 107/276 (38%), Gaps = 40/276 (14%)
Query: 266 TTCTFDCEEGFELMGAQSLQCTSSGN----WDNEKPTCKAVTCRAVRQPQNGSVRCSHSP 321
+T T+ C+ G+ L G +L C + W+ P+C A C + G+V + P
Sbjct: 1721 STVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA-PCGSRSTGSEGTVLSPNYP 1779
Query: 322 AGEFTFKSSCNFTCE--EGFMLQGPAQVECTTQGQWTQQI--PVCEAFQCTALSNPERGY 377
++ +C ++ + F++ G T+ + P ++ ++LS G
Sbjct: 1780 KN-YSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSG- 1837
Query: 378 MNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPP 437
LP +SG+ + F+ KG + P + +C +V +P
Sbjct: 1838 -ESLPLSSGN---QITIRFTSVGPITAKGFHFVY--------QAVPRTSSTQCSSVPEPR 1885
Query: 438 KGLVRCAHSPIG-EFTYKSSCAFSCEEGFELHGSTQLEC----TSQGQWTEEVPSCQVVK 492
G IG EF SS F C G+ LHGS + C S QW + +P+C +V
Sbjct: 1886 FG------RRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC-IVP 1938
Query: 493 CSSLAVPGKINMSCSGEPV-----FGTVCKFACPEG 523
C + K + G P V K PEG
Sbjct: 1939 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEG 1974
Score = 51.2 bits (121), Expect = 3e-06
Identities = 57/251 (22%), Positives = 87/251 (34%), Gaps = 63/251 (25%)
Query: 367 CTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGE----WDNEK 422
C PE G F GS+ +FSC++ +VL+G+K + C E W + +
Sbjct: 486 CPDPGEPENG-----KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHR 540
Query: 423 PTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCE------------EGFELH-G 469
P C+ C + Q P G + P ++ + C + E F+L G
Sbjct: 541 PVCKVKTCGSNLQGPSGTFTSPNFPF-QYDSNAQCVWVITAVNTNKVIQINFEEFDLEIG 599
Query: 470 STQLECTSQGQWTEEVPSCQVVKCSSL----------------------AVPGKINM--- 504
L G+ + QV+ S + +V K+N
Sbjct: 600 YDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEI 659
Query: 505 ---SCS--GEPVFG----------TVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEA 549
SC G P++G V +F C G+ L G + C WS +P C
Sbjct: 660 EKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIF 719
Query: 550 PTESNIPLVAG 560
P SN G
Sbjct: 720 PCLSNFTAPMG 730
Score = 50.4 bits (119), Expect = 5e-06
Identities = 40/154 (25%), Positives = 56/154 (36%), Gaps = 11/154 (7%)
Query: 163 CKCDPGFSGLKCEQI----VNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSS 218
C+ D +SG I +C P HGS + F S C +G+L
Sbjct: 3331 CQADGTWSGSSPHCIEPTQTSCENPGVPRHGS---QNNTFGFQVGSVVQFHCKKGHLLQG 3387
Query: 219 METMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFEL 278
T C+ WS P C C PA+ V P T + C+ GF L
Sbjct: 3388 STTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSH---GYTLIYTCQPGFFL 3444
Query: 279 MGAQSLQ-CTSSGNWDNEKPTCKAVTCRAVRQPQ 311
G + C S W + P C+A + V+ P+
Sbjct: 3445 AGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPR 3478
Score = 48.1 bits (113), Expect = 2e-05
Identities = 69/289 (23%), Positives = 98/289 (33%), Gaps = 69/289 (23%)
Query: 262 FPWNTTCTFDCEEGFELMGAQSLQCTSSGN----WDNEKPTCKAVTCRAVRQPQNGSVRC 317
F +T F C+E + L GA+S+ C W + +P CK TC + Q
Sbjct: 502 FSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQ-------- 553
Query: 318 SHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALS----NP 373
P+G FT S NF P Q + Q W I + ++ +
Sbjct: 554 --GPSGTFT---SPNF----------PFQYDSNAQCVWV--ITAVNTNKVIQINFEEFDL 596
Query: 374 ERGY--------------MNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWD 419
E GY L +GSF S + L+ + + G G
Sbjct: 597 EIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESV--GSVGFKV 654
Query: 420 NEKPTCEAVRCDAVHQPPKGLVRCAHSPIGE-FTYKSSCAFSCEEGFELHGSTQLECTSQ 478
N K E C P G+ G+ F+ + F C+ GFEL G + C
Sbjct: 655 NYKEI-EKESCGDPGTPLYGIRE------GDGFSNRDVLRFECQFGFELIGEKSIVCQEN 707
Query: 479 GQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLN 527
QW+ +P C S+ P GTV PEG+ N
Sbjct: 708 NQWSANIPICIFPCLSNFTAP------------MGTVLSPDYPEGYGNN 744
Score = 46.6 bits (109), Expect = 7e-05
Identities = 64/268 (23%), Positives = 104/268 (38%), Gaps = 32/268 (11%)
Query: 184 ESPEHGSLVCSHPLG-NFSYNSSCSISCDRGYLPS-SMETMQC-MSSGE--WSAPIPACN 238
E P+ G + + G NF SS S+ C+ G++ + ET+ C + G+ WS IP C
Sbjct: 833 ECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCG 892
Query: 239 VVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCT-----SSGNWD 293
C + +G + +PG +P + +CE E S++ T + N+D
Sbjct: 893 -APCGGHFSAPSGVI---LSPG-WPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYD 947
Query: 294 NEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQG 353
+ + P GS + P +F F SS NF ++L
Sbjct: 948 ----VLEVHDGPNLLSPLLGSYNGTQVP--QFLFSSS-NFI----YLLFTTDNSRSNNGF 996
Query: 354 QWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCG 413
+ + + C P G F GS+ FSC+ G+ L + L C
Sbjct: 997 KIHYESVTVNTYSCLDPGIPVHG-----RRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCE 1051
Query: 414 PTGEWDNEKPTCEAVRCDAVHQPPKGLV 441
W + PTC+A+ C + P G +
Sbjct: 1052 KNHWWSHPLPTCDAL-CGGDVRGPSGTI 1078
Score = 45.1 bits (105), Expect = 2e-04
Identities = 101/460 (21%), Positives = 145/460 (31%), Gaps = 118/460 (25%)
Query: 180 CTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE----WSAPIP 235
C PE+G + S +FS S+ SCD Y+ +++ C E WS P
Sbjct: 486 CPDPGEPENGKRIGS----DFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRP 541
Query: 236 ACNVVECDAVTNPANGFVECFQNPGSFPWNTTCT------------------FDCEEGFE 277
C V C + +G P + N C FD E G++
Sbjct: 542 VCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYD 601
Query: 278 L------------------------------MGAQ---SLQCTSSGNWDNEKPTCKAVTC 304
M +Q LQ S K K +
Sbjct: 602 TLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEK 661
Query: 305 RAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEA 364
+ P G+ F+ + F C+ GF L G + C QW+ IP+C
Sbjct: 662 ESCGDP--GTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPIC-I 718
Query: 365 FQC---------TALS-NPERGY---MNC---LPSASGSFRYGSSCEFSCEQGFVLKGSK 408
F C T LS + GY +NC + S GS + S +F E F K
Sbjct: 719 FPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVK 778
Query: 409 RLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELH 468
D + P + + P L +H EF S + GF +
Sbjct: 779 ----------DGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMS---GRGFNIT 825
Query: 469 GST--QLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPV-FGTVCKFACPEGW- 524
+T EC G +P IN G+ G+ C EG+
Sbjct: 826 YNTFGHNECPDPG-----IP---------------INARRFGDNFQLGSSISVICEEGFI 865
Query: 525 TLNGSAARTC---GATGHWSGLLPTCEAPTESNIPLVAGL 561
G+ TC WSGL+P C AP + +G+
Sbjct: 866 KTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGV 905
Score = 43.1 bits (100), Expect = 7e-04
Identities = 49/224 (21%), Positives = 76/224 (33%), Gaps = 63/224 (28%)
Query: 388 FRYGSSCEFSCEQGFVLKGSKRLQC--GPTGE--WDNEKPTCEAVRCDAVHQPPKGLVRC 443
++ GS+ + C+ G+VL+G L C G G W+ P+C A C + +G V
Sbjct: 1717 YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAP-CGSRSTGSEGTVLS 1775
Query: 444 AHSP---------------------IGEFTYKSSCAFSCEEGFE--------------LH 468
+ P G+F + + E ++ H
Sbjct: 1776 PNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSH 1835
Query: 469 GSTQLECTSQGQWT------------------EEVPSCQVVKCSSLAVPGKINMSCSGEP 510
L +S Q T + VP +CSS+ P + E
Sbjct: 1836 SGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEP-RFGRRIGNEF 1894
Query: 511 VFGTVCKFACPEGWTLNGSAARTC----GATGHWSGLLPTCEAP 550
G+ F C G+ L+GS A C + W+ LPTC P
Sbjct: 1895 AVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVP 1938
Score = 43.1 bits (100), Expect = 7e-04
Identities = 60/292 (20%), Positives = 100/292 (34%), Gaps = 68/292 (23%)
Query: 234 IPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQC----TSS 289
+P + +C +V P G + F ++ FDC G+ L G+ +++C S
Sbjct: 1870 VPRTSSTQCSSVPEPRFGR----RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSL 1925
Query: 290 GNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCN----FTCEEGFMLQGPA 345
W++ PTC V C + + G++ SP + ++ N T EG +Q
Sbjct: 1926 AQWNDSLPTC-IVPCGGILTKRKGTIL---SPGYPEPYDNNLNCVWKITVPEGAGIQVQV 1981
Query: 346 QVECTTQGQW---------TQQIPVCEAFQCTAL-----SNPERGYMNCLPSASGS---- 387
V T+ W P ++ T + S Y+N S S
Sbjct: 1982 -VSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGF 2040
Query: 388 ---------------------------FRYGSSCEFSCEQGFVLKGSKRLQC--GPTGEW 418
+ G F C+QG+ L+G + C GP W
Sbjct: 2041 HLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRW 2100
Query: 419 DNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCE--EGFELH 468
+ P C A +C G++ P G + C ++ GF +H
Sbjct: 2101 NYPIPICLA-QCGGAMSDFSGVILSPGFP-GNYPSSLDCTWTINLPIGFGVH 2150
Score = 43.1 bits (100), Expect = 7e-04
Identities = 96/448 (21%), Positives = 148/448 (33%), Gaps = 100/448 (22%)
Query: 180 CTALESPEHGSLVCSHPLGN-FSYNSSCSISCDRGYLPSSMETMQCM----SSGEWSAPI 234
C+++ P G + GN F+ SS C+ GY+ ++C S +W+ +
Sbjct: 1878 CSSVPEPRFGRRI-----GNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSL 1932
Query: 235 PACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCE--EGFELMGAQSLQCTSSGNW 292
P C +V C + G + P + N C + EG + Q + + NW
Sbjct: 1933 PTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQ-VQVVSFATEHNW 1990
Query: 293 D---------NEKPTCKAVTCRAVRQPQNGSVR---------CSHSPAG---EFTF--KS 329
D N P + + + N + S S AG E+T
Sbjct: 1991 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 2050
Query: 330 SC----------------------NFTCEEGFMLQGPAQVECTTQG--QWTQQIPVCEAF 365
SC +F C++G+ LQG + + C +W IP+
Sbjct: 2051 SCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPI---- 2106
Query: 366 QCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTC 425
CL G+ S S GF L C W P
Sbjct: 2107 --------------CLAQCGGAMSDFSGVILS--PGFPGNYPSSLDC----TWTINLPIG 2146
Query: 426 EAVRCDAVHQPPKGL-----VRCAHSP----IGEFTYKS--SCAFSCEEGFELHGSTQLE 474
V V+ + + VR S IG + S FS L+ +
Sbjct: 2147 FGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYS 2206
Query: 475 CTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTC 534
QG + + Q+ C P + + G F C G+TL G++A TC
Sbjct: 2207 QNKQG-FHIVYQAYQLQSCPDPR-PFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTC 2264
Query: 535 --GATGHWSGLLPTCEAPTESNIPLVAG 560
G + +W+ LP CEA NI + G
Sbjct: 2265 LHGVSRNWNHPLPRCEALCGGNITAMNG 2292
Score = 42.0 bits (97), Expect = 0.002
Identities = 52/232 (22%), Positives = 83/232 (35%), Gaps = 59/232 (25%)
Query: 189 GSLVCSHPLG-NFSYNSSCSISCDRGYLPSSMETMQCMSSGE----WSAPIPACNVVECD 243
G+++ LG ++ S+ + CD GY+ T+ C+ + W+ +P+C+ C
Sbjct: 1705 GNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCH-APCG 1763
Query: 244 AVTNPANGFVECFQNP----------------------GSFPWNTTCTFDCEEGFE---- 277
+ + + G V P G F + T D E ++
Sbjct: 1764 SRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQ 1823
Query: 278 -------LMGAQSLQC--TSSGN-----WDNEKP-TCKAVTCRAVRQPQNGSVRCSHSP- 321
L G+ S + SSGN + + P T K P+ S +CS P
Sbjct: 1824 QSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPE 1883
Query: 322 -------AGEFTFKSSCNFTCEEGFMLQGPAQVECTT----QGQWTQQIPVC 362
EF SS F C G++L G + C T QW +P C
Sbjct: 1884 PRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1935
Score = 34.7 bits (78), Expect = 0.26
Identities = 22/68 (32%), Positives = 33/68 (48%), Gaps = 7/68 (10%)
Query: 250 NGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTS--SGNWDNEKPTCKAVTCRAV 307
NGFV F T +F+C G+ L+G +L C S NW++ P C+A+ C
Sbjct: 2232 NGFVI----GNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL-CGGN 2286
Query: 308 RQPQNGSV 315
NG++
Sbjct: 2287 ITAMNGTI 2294
Score = 32.7 bits (73), Expect = 1.00
Identities = 20/78 (25%), Positives = 31/78 (39%), Gaps = 6/78 (7%)
Query: 388 FRYGSSCEFSCEQGFVLKGSKRLQC----GPTGEWDNEKPTCEAV-RCDAVHQPPKGLVR 442
F G +SC G++L G +L C T WD P C A C + G++
Sbjct: 194 FDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIIS 253
Query: 443 CAHSPIGEFTYKSSCAFS 460
P E+ + C ++
Sbjct: 254 SPSFP-NEYHNNADCTWT 270
Score = 30.4 bits (67), Expect = 5.0
Identities = 16/45 (35%), Positives = 22/45 (48%), Gaps = 4/45 (8%)
Query: 513 GTVCKFACPEGWTLNGSAARTC--GATGH--WSGLLPTCEAPTES 553
G+ + C G+ L G + TC G G W+ LP+C AP S
Sbjct: 1720 GSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGS 1764
Score = 30.0 bits (66), Expect = 6.5
Identities = 13/38 (34%), Positives = 17/38 (44%), Gaps = 3/38 (7%)
Query: 267 TCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKA 301
T F C+ G+EL G + + C N W P C A
Sbjct: 1549 TVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIA 1586
Score = 29.6 bits (65), Expect = 8.5
Identities = 17/58 (29%), Positives = 25/58 (43%), Gaps = 9/58 (15%)
Query: 436 PPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLEC----TSQGQWTEEVPSCQ 489
PPKG++ +G+ +SC G+ L G QL C + W VP C+
Sbjct: 184 PPKGVLYGTRFDVGD-----KIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICR 236
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 196 bits (497), Expect = 7e-50
Identities = 116/433 (26%), Positives = 189/433 (43%), Gaps = 43/433 (9%)
Query: 121 DVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFS--GLKCEQIV 178
D G WN S + C + CS H C+ +Y C C P ++ G C + +
Sbjct: 1732 DNGSWNGVSPSCLDVDEC----AVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPI 1787
Query: 179 NCTALESPEHGSLVCSHPLGN-FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPAC 237
C A +PE+G H G ++ + + SC GY + + C+ SGEW+ IP C
Sbjct: 1788 KCKAPGNPENG-----HSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYC 1842
Query: 238 NVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKP 297
V C P NG +E +F + + T+ C +G+ L G + C ++ +W + P
Sbjct: 1843 KAVSCGKPAIPENGCIEEL----AFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPP 1898
Query: 298 TCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQ 357
C+ V C + NG S T+ S+ +++C+ G+ LQGP+ +ECT G W +
Sbjct: 1899 VCEPVKCSSPENINNGKYILS-----GLTYLSTASYSCDTGYSLQGPSIIECTASGIWDR 1953
Query: 358 QIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGE 417
P C C E + +F + ++ ++C++G+ L G ++C G+
Sbjct: 1954 APPACHLVFC-----GEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGK 2008
Query: 418 WDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTS 477
W C AV CD AH G+ + + C +G+ L ++QL C +
Sbjct: 2009 WSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAF-----YYCSDGYSLADNSQLLCNA 2063
Query: 478 QGQWT----EEVPSCQVVKCSSLAVPGKINMS-----CSGEPVFGTVCKFACPEGWTLNG 528
QG+W +++P C C P ++ S + G+V F C EG+ LN
Sbjct: 2064 QGKWVPPEGQDMPRCIAHFCEK---PPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNT 2120
Query: 529 SAARTCGATGHWS 541
SA C G W+
Sbjct: 2121 SAKIECMRGGQWN 2133
Score = 185 bits (470), Expect = 9e-47
Identities = 108/387 (27%), Positives = 171/387 (44%), Gaps = 37/387 (9%)
Query: 178 VNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPAC 237
+ C +PE+G L + S S+ SC G++ + + C+ + +WS P C
Sbjct: 2715 IECDLPTAPENGFLRFTET----SMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRC 2770
Query: 238 NVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKP 297
+ C NG ++ ++ + +T ++C+ G+ L G + C NWD ++P
Sbjct: 2771 EAISCKKPNPVMNGSIK----GSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEP 2826
Query: 298 TCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQ 357
C V C + NG VR E+TF+ +TC EGF+L+G C G W+
Sbjct: 2827 ICIPVDCSSPPVSANGQVR-----GDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSG 2881
Query: 358 QIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGE 417
P C +C G L + + F C +G++L G+ +L C G
Sbjct: 2882 ATPDCVPVRCATPPQLANGVTEGL-----DYGFMKEVTFHCHEGYILHGAPKLTCQSDGN 2936
Query: 418 WDNEKPTCEAVRCDAVHQPPKGLVRCAHS-PIG-EFTYKSSCAFSCEEGFELHGSTQLEC 475
WD E P C+ V C PP+ L AH P G F + + C G++LHG++ C
Sbjct: 2937 WDAEIPLCKPVNCG----PPEDL---AHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRC 2989
Query: 476 TSQGQWTEEVPSCQVVKCSSLAVP-GKIN---MSCSGEPVFGTVCKFACPEGWTLNGSAA 531
S G W+ PSC +CS+ + G +N C G + C +G+ L G +
Sbjct: 2990 LSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTDFDC------GKAARIQCFKGFKLLGLSE 3043
Query: 532 RTCGATGHWSGLLPTCEAPTESNIPLV 558
TC A G WS P CE + ++P++
Sbjct: 3044 ITCEADGQWSSGFPHCEHTSCGSLPMI 3070
Score = 182 bits (463), Expect = 6e-46
Identities = 97/365 (26%), Positives = 162/365 (44%), Gaps = 31/365 (8%)
Query: 199 NFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQN 258
NF Y + S +C+ GY + C G W+ P+C +ECD T P NGF+ +
Sbjct: 2674 NFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTET 2733
Query: 259 PGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCS 318
+ + C+ G L G+ C + W P C+A++C+ NGS++ S
Sbjct: 2734 ----SMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGS 2789
Query: 319 HSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYM 378
+ +T+ S+ + C+ G++L G + C W + P+C C++ G +
Sbjct: 2790 N-----YTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQV 2844
Query: 379 NCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPK 438
+ + E++C +GF+L+G++ C G W P C VRC Q
Sbjct: 2845 R-----GDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLAN 2899
Query: 439 GLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAV 498
G+ ++ + F C EG+ LHG+ +L C S G W E+P C+ V C
Sbjct: 2900 GVTEGL-----DYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNC----- 2949
Query: 499 PGKINMSCSGEP-----VFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTES 553
G G P + G ++ C G+ L+G+++R C + G WSG P+C P
Sbjct: 2950 -GPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSC-LPCRC 3007
Query: 554 NIPLV 558
+ P++
Sbjct: 3008 STPVI 3012
Score = 178 bits (452), Expect = 1e-44
Identities = 104/397 (26%), Positives = 163/397 (41%), Gaps = 63/397 (15%)
Query: 204 SSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFP 263
S ++ CD G+ C++ G+W+ P+P C + C NG F + F
Sbjct: 1652 SKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENG----FHSADDFY 1707
Query: 264 WNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTC------------------------ 299
+T T+ C G+ L+G + CT +G+W+ P+C
Sbjct: 1708 AGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGS 1767
Query: 300 -----------------KAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQ 342
+ + C+A P+NG HS +T + F+C+EG+ L
Sbjct: 1768 YICSCVPPYTGDGKNCAEPIKCKAPGNPENG-----HSSGEIYTVGAEVTFSCQEGYQLM 1822
Query: 343 GPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGF 402
G ++ C G+W IP C+A C + PE G + L +F +GS + C +G+
Sbjct: 1823 GVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEEL-----AFTFGSKVTYRCNKGY 1877
Query: 403 VLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCE 462
L G K C W + P CE V+C + G + TY S+ ++SC+
Sbjct: 1878 TLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNG-----KYILSGLTYLSTASYSCD 1932
Query: 463 EGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEP-VFGTVCKFACP 521
G+ L G + +ECT+ G W P+C +V C P + +G F + C
Sbjct: 1933 TGYSLQGPSIIECTASGIWDRAPPACHLVFCGE--PPAIKDAVITGNNFTFRNTVTYTCK 1990
Query: 522 EGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIPLV 558
EG+TL G C A G WS C A + P+V
Sbjct: 1991 EGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIV 2027
Score = 177 bits (448), Expect = 3e-44
Identities = 130/520 (25%), Positives = 204/520 (39%), Gaps = 100/520 (19%)
Query: 97 WAPGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLAL-------CYTAACTNTSCS 149
W P E + + C+ + ++ V E SK K A C NTS
Sbjct: 2067 WVPPEGQDMPR---CIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAK 2123
Query: 150 GHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLG-NFSYNSSCSI 208
+C G + C + E S++ + G N+S+ + +
Sbjct: 2124 -------------IECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAY 2170
Query: 209 SCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVE-----CFQ------ 257
SC++G+ + C ++G+WS+PIP C+ V C NGF+E F+
Sbjct: 2171 SCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQ 2230
Query: 258 -NPG--------------------------------------------SFPWNTTCTFDC 272
NPG +F + F C
Sbjct: 2231 CNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFC 2290
Query: 273 EEGFELMGAQSLQCTSSGNWDNE-KPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSC 331
EG+EL+G S C SG W+ + P C C +N V + T
Sbjct: 2291 NEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELT-----TEVGVV 2345
Query: 332 NFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYG 391
F+C+EG +LQGP+ ++C QW PVC+ CT P +P S + +G
Sbjct: 2346 TFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCT----PPPLISFGVPIPSSALHFG 2401
Query: 392 SSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEF 451
S+ ++SC GF L+G+ C P G W + P C V C + P G++ +
Sbjct: 2402 STVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGII-----DVQGL 2456
Query: 452 TYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKC--SSLAVPGKINMSCSGE 509
Y S+ ++C+ GFEL G+T C G W P+C+ ++C + GK + + +
Sbjct: 2457 AYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYT---D 2513
Query: 510 PVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEA 549
+G ++C G+ L G +A TC TG W P+C A
Sbjct: 2514 LHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNA 2553
Score = 172 bits (437), Expect = 6e-43
Identities = 112/431 (25%), Positives = 177/431 (41%), Gaps = 76/431 (17%)
Query: 165 CDPGFSGL------------------KCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSC 206
CDPGF + CE+I +C E+G H +F S+
Sbjct: 1658 CDPGFQLVGNPVQYCLNQGQWTQPLPHCERI-SCGVPPPLENGF----HSADDFYAGSTV 1712
Query: 207 SISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSF---- 262
+ C+ GY M C +G W+ P+C V+ AV + + C GS+
Sbjct: 1713 TYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSC 1772
Query: 263 -------------------PWN--------------TTCTFDCEEGFELMGAQSLQCTSS 289
P N TF C+EG++LMG + C S
Sbjct: 1773 VPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLES 1832
Query: 290 GNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVEC 349
G W++ P CKAV+C P+NG C A FTF S + C +G+ L G + C
Sbjct: 1833 GEWNHLIPYCKAVSCGKPAIPENG---CIEELA--FTFGSKVTYRCNKGYTLAGDKESSC 1887
Query: 350 TTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKR 409
W+ PVCE +C++ N G Y S+ +SC+ G+ L+G
Sbjct: 1888 LANSSWSHSPPVCEPVKCSSPENINNG-----KYILSGLTYLSTASYSCDTGYSLQGPSI 1942
Query: 410 LQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHG 469
++C +G WD P C V C +PP ++ A FT++++ ++C+EG+ L G
Sbjct: 1943 IECTASGIWDRAPPACHLVFCG---EPP--AIKDAVITGNNFTFRNTVTYTCKEGYTLAG 1997
Query: 470 STQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGS 529
+EC + G+W+ C V C + + + +FG + + C +G++L +
Sbjct: 1998 LDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPE-TAHRLFGDIAFYYCSDGYSLADN 2056
Query: 530 AARTCGATGHW 540
+ C A G W
Sbjct: 2057 SQLLCNAQGKW 2067
Score = 172 bits (435), Expect = 1e-42
Identities = 107/394 (27%), Positives = 164/394 (41%), Gaps = 28/394 (7%)
Query: 173 KCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSA 232
+CE I +C +GS+ S N++Y S+ CD GY+ + E C W
Sbjct: 2769 RCEAI-SCKKPNPVMNGSIKGS----NYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDE 2823
Query: 233 PIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNW 292
P C V+C + ANG V + + + C EGF L GA+S C ++G+W
Sbjct: 2824 DEPICIPVDCSSPPVSANGQVR----GDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSW 2879
Query: 293 DNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQ 352
P C V C Q NG ++ F F C EG++L G ++ C +
Sbjct: 2880 SGATPDCVPVRCATPPQLANGVTE-----GLDYGFMKEVTFHCHEGYILHGAPKLTCQSD 2934
Query: 353 GQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQC 412
G W +IP+C+ C + G+ N SF +G ++ C G+ L G+ +C
Sbjct: 2935 GNWDAEIPLCKPVNCGPPEDLAHGFPNGF-----SFIHGGHIQYQCFPGYKLHGNSSRRC 2989
Query: 413 GPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQ 472
G W P+C RC ++ +F + C +GF+L G ++
Sbjct: 2990 LSNGSWSGSSPSCLPCRCSTP------VIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSE 3043
Query: 473 LECTSQGQWTEEVPSCQVVKCSSLA-VPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAA 531
+ C + GQW+ P C+ C SL +P S V ++C G+ + GS+
Sbjct: 3044 ITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKE--NVITYSCRSGYVIQGSSD 3101
Query: 532 RTCGATGHWSGLLPTCEAPTESNIPLVAGLSAAG 565
C G WS P CE + + P VA A G
Sbjct: 3102 LICTEKGVWSQPYPVCEPLSCGSPPSVANAVATG 3135
Score = 171 bits (434), Expect = 1e-42
Identities = 119/466 (25%), Positives = 185/466 (39%), Gaps = 84/466 (18%)
Query: 161 YTCKCDPGFSGLKCEQIVNCTAL---------ESPEHGSLVCSHPL----GNFSYNS--- 204
YTCK PGF E + N T L P ++ C P G FSY
Sbjct: 2464 YTCK--PGF-----ELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHY 2516
Query: 205 --SCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSF 262
+ + SC+RG+ + C+ +G+W P+CN + CD+ NGFVE +
Sbjct: 2517 GQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVE----GADY 2572
Query: 263 PWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCR----------------- 305
+ + C GF++ G C SG W + PTC + C
Sbjct: 2573 SYGAIIIYSCFPGFQVAGHAMQTCEESG-WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQ 2631
Query: 306 ------------------------AVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFML 341
AV + + + + F + + ++TC G+ L
Sbjct: 2632 GYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYEL 2691
Query: 342 QGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQG 401
G + C G W P C + +C + PE G++ ++ GS+ ++SC+ G
Sbjct: 2692 LGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETS-----MGSAVQYSCKPG 2746
Query: 402 FVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSC 461
+L GS C +W P CEA+ C + G ++ ++ +TY S+ + C
Sbjct: 2747 HILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSN-----YTYLSTLYYEC 2801
Query: 462 EEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSG-EPVFGTVCKFAC 520
+ G+ L+G+ + C W E+ P C V CSS P N G E F ++ C
Sbjct: 2802 DPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSS--PPVSANGQVRGDEYTFQKEIEYTC 2859
Query: 521 PEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIPLVAGLSAAGL 566
EG+ L G+ +R C A G WSG P C + P +A GL
Sbjct: 2860 NEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGL 2905
Score = 155 bits (393), Expect = 8e-38
Identities = 98/346 (28%), Positives = 145/346 (41%), Gaps = 30/346 (8%)
Query: 200 FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNP 259
+++ +C+ G+L + C+++G WS P C V C ANG E
Sbjct: 2849 YTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLD-- 2906
Query: 260 GSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSH 319
+ + TF C EG+ L GA L C S GNWD E P CK V C +G
Sbjct: 2907 --YGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHG------ 2958
Query: 320 SPAG-EFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNP--ERG 376
P G F + C G+ L G + C + G W+ P C +C S P E G
Sbjct: 2959 FPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRC---STPVIEYG 3015
Query: 377 YMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQP 436
+N F G + C +GF L G + C G+W + P CE C ++
Sbjct: 3016 TVN-----GTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMI 3070
Query: 437 PKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSL 496
P + S ++ +SC G+ + GS+ L CT +G W++ P C+ + C S
Sbjct: 3071 PNAFISETSS-----WKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGS- 3124
Query: 497 AVPGKINMSCSGEP-VFGTVCKFACPEGWTLN-GSAARTCGATGHW 540
P N +GE + + K C EG+T++ + TC G W
Sbjct: 3125 -PPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRW 3169
Score = 155 bits (392), Expect = 1e-37
Identities = 102/361 (28%), Positives = 150/361 (41%), Gaps = 26/361 (7%)
Query: 199 NFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPI-PACNVVECDAVTNPANGFV--EC 255
NF S C+ GY + C SG+W+ P C +C N V E
Sbjct: 2279 NFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKEL 2338
Query: 256 FQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSV 315
G TF C+EG L G L+C S W++ P CK V C G
Sbjct: 2339 TTEVG------VVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVP 2392
Query: 316 RCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPER 375
P+ F S+ ++C GF L+G + C G W+ +P C +C
Sbjct: 2393 ----IPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPN 2448
Query: 376 GYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQ 435
G ++ A Y S+ ++C+ GF L G+ CG G W KPTC+A+ C
Sbjct: 2449 GIIDVQGLA-----YLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIEC----L 2499
Query: 436 PPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSS 495
PK ++ S + Y + +SC GF L G + L C G W + PSC + C S
Sbjct: 2500 KPKEILNGKFS-YTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDS 2558
Query: 496 LAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNI 555
P + + +G + ++C G+ + G A +TC +G WS +PTC P + +
Sbjct: 2559 -PQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG-WSSSIPTC-MPIDCGL 2615
Query: 556 P 556
P
Sbjct: 2616 P 2616
Score = 138 bits (348), Expect = 1e-32
Identities = 89/371 (23%), Positives = 143/371 (38%), Gaps = 40/371 (10%)
Query: 159 NNYTCKCDPGFSGLKCEQIVNCTALESP--EHGSLVCSHPLGNFSYNSSCSISCDRGYLP 216
+ +TC+ D G + ++C+ + P E+ + + H +FS N S+SC GY
Sbjct: 3159 DTFTCQKD----GRWFPERISCSPKKCPLPENITHILVHG-DDFSVNRQVSVSCAEGYTF 3213
Query: 217 SSMETMQCMSSGEWSAPIP--ACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEE 274
+ C G W P +C+ V C +P +GFV + + +T + CE
Sbjct: 3214 EGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVV----GSKYTFESTIIYQCEP 3269
Query: 275 GFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFT 334
G+EL G + C + W CK C + NG + G + ++
Sbjct: 3270 GYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGKADIENRTTGP-----NVVYS 3324
Query: 335 CEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQC-TALSNPERGYMNCLPSASGSFRYGSS 393
C G+ L+GP++ CT G W+ +P+C+ C PE + + F +
Sbjct: 3325 CNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALL-----SEKEFYVDQN 3379
Query: 394 CEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTY 453
C +GF+L+G + C P W CE + C + R H + Y
Sbjct: 3380 VSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVH-----YQY 3434
Query: 454 KSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFG 513
+SC G+ L G + C G WT P C+ V C +
Sbjct: 3435 GDMITYSCYSGYMLEGFLRSVCLENGTWTSP-PICRAV----------CRFPCQNGGICQ 3483
Query: 514 TVCKFACPEGW 524
+CPEGW
Sbjct: 3484 RPNACSCPEGW 3494
Score = 131 bits (329), Expect = 2e-30
Identities = 80/292 (27%), Positives = 131/292 (44%), Gaps = 18/292 (6%)
Query: 150 GHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSIS 209
G +C ++ C C+ G+ G + CTA S + P G+ SSC
Sbjct: 292 GSCKCGTHTGHFECICEKGYYGKGLQY--ECTACPSGTY------KPEGSPGGISSCIPC 343
Query: 210 CDRGYL--PSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTT 267
D + P S C+ + A C +V C A+ P NG+ QN + +N
Sbjct: 344 PDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYF--IQNTCNNHFNAA 401
Query: 268 CTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTF 327
C C GF+L+G+ + C +G W + C+ TC +RQP++G + CS E +
Sbjct: 402 CGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCS---TREMLY 458
Query: 328 KSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGS 387
K++C C+EG+ L+G ++ C QW P C C+ P+ ++
Sbjct: 459 KTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQP 518
Query: 388 FRYGSSCEFSCEQGFVLKGSKR-LQCGPTGEWD--NEKPTCEAVRCDAVHQP 436
++G+ C SC QGF+L G K L+C +G+W+ + C+ V ++ P
Sbjct: 519 AKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCP 570
Score = 130 bits (326), Expect = 5e-30
Identities = 91/388 (23%), Positives = 153/388 (39%), Gaps = 24/388 (6%)
Query: 178 VNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAP---- 233
V+C +H S +H L + C GY + + C + G+W P
Sbjct: 2019 VSCDEPPIVDHASPETAHRL----FGDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQD 2074
Query: 234 IPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWD 293
+P C C+ + + +E F + +F C EGF L + ++C G W+
Sbjct: 2075 MPRCIAHFCEKPPSVSYSILESVSK-AKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWN 2133
Query: 294 NEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQG 353
P+ ++ C VR + S+ ++ ++F + ++C +GF ++G + C G
Sbjct: 2134 ---PSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATG 2190
Query: 354 QWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCG 413
QW+ IP C C E G+ L +G + S + C G+ GS C
Sbjct: 2191 QWSSPIPTCHPVSCGEPPKVENGF---LEHTTGRI-FESEVRYQCNPGYKSVGSPVFVCQ 2246
Query: 414 PTGEWDNEKPT-CEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQ 472
W +E P C + C G ++ + +G S F C EG+EL G +
Sbjct: 2247 ANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVG-----SKVQFFCNEGYELVGDSS 2301
Query: 473 LECTSQGQWTEEV-PSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAA 531
C G+W ++ P C KC + + G V F+C EG L G +
Sbjct: 2302 WTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGVVT-FSCKEGHVLQGPSV 2360
Query: 532 RTCGATGHWSGLLPTCEAPTESNIPLVA 559
C + W+ P C+ + PL++
Sbjct: 2361 LKCLPSQQWNDSFPVCKIVLCTPPPLIS 2388
Score = 127 bits (320), Expect = 2e-29
Identities = 85/366 (23%), Positives = 147/366 (40%), Gaps = 30/366 (8%)
Query: 199 NFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQN 258
+F + I C +G+ + + C + G+WS+ P C C ++ N F+
Sbjct: 3021 DFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFI---SE 3077
Query: 259 PGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCS 318
S+ N T+ C G+ + G+ L CT G W P C+ ++C + SV +
Sbjct: 3078 TSSWKEN-VITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGS-----PPSVANA 3131
Query: 319 HSPAGEFTFKSSCNFTCEEGFMLQGPAQV-ECTTQGQWTQQIPVCEAFQCTALSNPERGY 377
+ T++S C EG+ + C G+W + C +C N
Sbjct: 3132 VATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPEN----- 3186
Query: 378 MNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDN--EKPTCEAVRCDAVHQ 435
+ + F SC +G+ +G C G W+ +C V C
Sbjct: 3187 ITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPES 3246
Query: 436 PPKGLVRCAHSPIG-EFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCS 494
P G V +G ++T++S+ + CE G+EL G+ + C QW+ V C+ +C
Sbjct: 3247 PEHGFV------VGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCE 3300
Query: 495 SLA--VPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTE 552
+ + GK ++ G ++C G++L G + C G WS +P C+ P
Sbjct: 3301 TPLEFLNGKADIE---NRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCK-PNP 3356
Query: 553 SNIPLV 558
+P V
Sbjct: 3357 CPVPFV 3362
Score = 123 bits (308), Expect = 6e-28
Identities = 79/287 (27%), Positives = 113/287 (39%), Gaps = 57/287 (19%)
Query: 313 GSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSN 372
GSV + + + S N C+ GF L G C QGQWTQ +P CE C
Sbjct: 1636 GSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPP 1695
Query: 373 PERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTC------- 425
E G+ ++ F GS+ + C G+ L G R+ C G W+ P+C
Sbjct: 1696 LENGF-----HSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECA 1750
Query: 426 ----------------------------------EAVRCDAVHQPPKGLVRCAHSPIGEF 451
E ++C A P G HS +
Sbjct: 1751 VGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENG-----HSSGEIY 1805
Query: 452 TYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPV 511
T + FSC+EG++L G T++ C G+W +P C+ V C A+P C E
Sbjct: 1806 TVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPEN---GCIEELA 1862
Query: 512 F--GTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIP 556
F G+ + C +G+TL G +C A WS P CE P + + P
Sbjct: 1863 FTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCE-PVKCSSP 1908
Score = 120 bits (302), Expect = 3e-27
Identities = 83/353 (23%), Positives = 137/353 (38%), Gaps = 25/353 (7%)
Query: 201 SYNSSCSISCDRGY-LPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNP 259
+Y S + C GY + + +T C G W +C+ +C N + V +
Sbjct: 3139 TYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILV----HG 3194
Query: 260 GSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDN--EKPTCKAVTCRAVRQPQNGSVRC 317
F N + C EG+ G C G W+ +C V+C P++G V
Sbjct: 3195 DDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFVVG 3254
Query: 318 SHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGY 377
S ++TF+S+ + CE G+ L+G + C QW+ + +C+ +C G
Sbjct: 3255 S-----KYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNGK 3309
Query: 378 MNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPP 437
+ +G + +SC +G+ L+G C G W + P C+ C P
Sbjct: 3310 ADIENRTTGP-----NVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIP 3364
Query: 438 KGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLA 497
+ + EF + + C EGF L G + C WT+ C+ + C A
Sbjct: 3365 ENALLSEK----EFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPA 3420
Query: 498 -VPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEA 549
V I + +G + ++C G+ L G C G W+ P C A
Sbjct: 3421 HVENAIARGVHYQ--YGDMITYSCYSGYMLEGFLRSVCLENGTWTS-PPICRA 3470
Score = 117 bits (294), Expect = 2e-26
Identities = 78/343 (22%), Positives = 126/343 (36%), Gaps = 22/343 (6%)
Query: 209 SCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTC 268
SC GY+ + C G WS P P C + C + + AN + + +
Sbjct: 3089 SCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVA----TGEAHTYESEV 3144
Query: 269 TFDCEEGFEL-MGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTF 327
C EG+ + + C G W E+ +C C P+N + H +F+
Sbjct: 3145 KLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPL---PENITHILVHGD--DFSV 3199
Query: 328 KSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIP--VCEAFQCTALSNPERGYMNCLPSAS 385
+ +C EG+ +G C G W C C +PE G++
Sbjct: 3200 NRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFV-----VG 3254
Query: 386 GSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAH 445
+ + S+ + CE G+ L+G++ C +W C+ RC+ + G
Sbjct: 3255 SKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNG-----K 3309
Query: 446 SPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMS 505
+ I T + +SC G+ L G ++ CT G W+ VP C+ C V + +
Sbjct: 3310 ADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALL 3369
Query: 506 CSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCE 548
E C EG+ L G TC W+ CE
Sbjct: 3370 SEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCE 3412
Score = 115 bits (289), Expect = 9e-26
Identities = 91/340 (26%), Positives = 140/340 (41%), Gaps = 44/340 (12%)
Query: 214 YLPSSMETMQCMSSGEWSAPIPACNVVECDAV--TNPANGFVECFQNPGSFPWNT-TCTF 270
YL S E + ++ +P+ + ++ D V + + +C GS T T F
Sbjct: 244 YLLHSFEEFEALARRALHEDLPSGSFIQDDMVHCSYLCDEGKDCCDRMGSCKCGTHTGHF 303
Query: 271 DC--EEGFELMGAQSLQCTS--SGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFT 326
+C E+G+ G Q +CT+ SG + E +C + S S SP
Sbjct: 304 ECICEKGYYGKGLQ-YECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPE---- 358
Query: 327 FKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASG 386
+ C EG+ G CE C AL PE GY +
Sbjct: 359 -----DCVCREGYRASGQT----------------CELVHCPALKPPENGYFI---QNTC 394
Query: 387 SFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHS 446
+ + ++C C GF L GS + C P G W + C C + QP G + C+
Sbjct: 395 NNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTR 454
Query: 447 PIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMS- 505
E YK++C +C+EG+ L GS +L C QW P C CS+ +P + +S
Sbjct: 455 ---EMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISP 511
Query: 506 --CSGEPV-FGTVCKFACPEGWTLNG-SAARTCGATGHWS 541
C +P FGT+C +C +G+ L+G C +G W+
Sbjct: 512 HNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWN 551
Score = 77.4 bits (189), Expect = 4e-14
Identities = 64/239 (26%), Positives = 92/239 (38%), Gaps = 41/239 (17%)
Query: 313 GSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSN 372
GS +C G T C CE+G+ +G Q ECT T + + +
Sbjct: 292 GSCKC-----GTHTGHFEC--ICEKGYYGKG-LQYECTACPSGTYKPEGSPGGISSCIPC 343
Query: 373 PERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDA 432
P+ + + S S + C +G+ G TCE V C A
Sbjct: 344 PDENHTSPPGSTSPE-------DCVCREGYRASGQ----------------TCELVHCPA 380
Query: 433 VHQPPKGLV---RCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQ 489
+ P G C + + ++C C GF+L GS+ + C G W+ C+
Sbjct: 381 LKPPENGYFIQNTCNNH------FNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCR 434
Query: 490 VVKCSSLAVPGKINMSCSG-EPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTC 547
V C L P ++SCS E ++ T C AC EG+ L GS TC W G P C
Sbjct: 435 VRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRC 493
Score = 47.8 bits (112), Expect = 3e-05
Identities = 44/190 (23%), Positives = 70/190 (36%), Gaps = 37/190 (19%)
Query: 143 CTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNF-- 200
C+++ C G CV+ + Y C C GF GL CE VN +P + VC +G F
Sbjct: 1273 CSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVN-ECQSNPCLNNAVCEDQVGGFLC 1331
Query: 201 -------------SYNSSCSISCDRG-YLPSSMETMQCMSSGEWSAPIPACNVVECDAVT 246
+ + S C G + +C+ + ++ N+ EC +
Sbjct: 1332 KCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQ--S 1389
Query: 247 NPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTS-------SGNW-----DN 294
NP C S+ + C+ GF ++ Q T SG + D
Sbjct: 1390 NPCRNQATCVDELNSY------SCKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVMLDG 1443
Query: 295 EKPTCKAVTC 304
P+ A+TC
Sbjct: 1444 MLPSLHALTC 1453
Score = 43.1 bits (100), Expect = 7e-04
Identities = 39/137 (28%), Positives = 57/137 (41%), Gaps = 22/137 (16%)
Query: 398 CEQGFVLKGSKRLQCGPTGEWDN-EKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYK-- 454
C G VL+G + C P G + N E TCE+ R + +Q +G + C P G +T
Sbjct: 988 CRPGSVLRGRMCVNC-PLGTYYNLEHFTCESCRIGS-YQDEEGQLECKLCPSGMYTEYIH 1045
Query: 455 ----SSCAFSCEEG-FELHGSTQLECTSQGQWTEEVPSCQVVKC---SSLAVPGKINMSC 506
S C C++G + G E G + + S + C +S G +N+S
Sbjct: 1046 SRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSCPENTSTVKRGAVNISA 1105
Query: 507 SGEPVFGTVCKFACPEG 523
G P CPEG
Sbjct: 1106 CGVP---------CPEG 1113
Score = 40.0 bits (92), Expect = 0.006
Identities = 28/88 (31%), Positives = 35/88 (39%), Gaps = 11/88 (12%)
Query: 143 CTNTSCSGHGECVETINNYTCKCDPGFSGLKCE-QIVNCTALESPEHGSLVCSHPLGNFS 201
C C G C + Y C C G++GLKCE I C+ L +G VC +G F
Sbjct: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNG--VCKDLVGEF- 1253
Query: 202 YNSSCSISCDRGYLPSSME--TMQCMSS 227
C GY E +C SS
Sbjct: 1254 -----ICECPSGYTGQRCEENINECSSS 1276
Score = 39.3 bits (90), Expect = 0.011
Identities = 34/152 (22%), Positives = 60/152 (39%), Gaps = 24/152 (15%)
Query: 143 CTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVN-CTALESPEHGSLVCSHPLGNFS 201
C+ C +G C + + + C+C G++G +CE+ +N C++ SP +C + +
Sbjct: 1235 CSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSS--SPCLNKGICVDGVAGY- 1291
Query: 202 YNSSCSISCDRGY--LPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNP 259
+C +G+ L E +C S+ P N C+ + GF+ C P
Sbjct: 1292 -----RCTCVKGFVGLHCETEVNECQSN-------PCLNNAVCE---DQVGGFL-CKCPP 1335
Query: 260 GSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN 291
G T C + +E C N
Sbjct: 1336 GFL--GTRCGKNVDECLSQPCKNGATCKDGAN 1365
Score = 38.5 bits (88), Expect = 0.018
Identities = 43/166 (25%), Positives = 57/166 (34%), Gaps = 41/166 (24%)
Query: 395 EFSCEQGFVLKGSKRLQCG--PTGEWDNEKPTCEAVRC----DAVHQPPKGLVRCAHSPI 448
E CE+G+ KG + +C P+G + E C D H P G
Sbjct: 304 ECICEKGYYGKGLQ-YECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGS-------- 354
Query: 449 GEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGK---INMS 505
T C C EG+ G T C++V C +L P I +
Sbjct: 355 ---TSPEDCV--CREGYRASGQT----------------CELVHCPALKPPENGYFIQNT 393
Query: 506 CSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPT 551
C+ F C C G+ L GS+ C G WSG C T
Sbjct: 394 CNNH--FNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRT 437
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 179 bits (453), Expect = 9e-45
Identities = 110/428 (25%), Positives = 167/428 (39%), Gaps = 69/428 (16%)
Query: 176 QIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIP 235
++++C +L P +G+ + + + Y ++ +C+ GY +C+++G WS
Sbjct: 2619 RVISCGSLSFPPNGNKIGTLTV----YGATAIFTCNTGYTLVGSHVRECLANGLWSGSET 2674
Query: 236 ACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNE 295
C C + NG + + F + T + C GF L+G C W +
Sbjct: 2675 RCLAGHCGSPDPIVNGHI----SGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQ 2730
Query: 296 KPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQW 355
P C +TC P +G S EF NFTC G++LQG ++ +C + GQW
Sbjct: 2731 TPVCVPITCGHPGNPAHGFTNGS-----EFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQW 2785
Query: 356 TQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPT 415
+ +P C C+ E + + SF YG S + C++GF L GS L C
Sbjct: 2786 SSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMAN 2845
Query: 416 GEWDNEKPTCEAVRCD-------------------AVHQPPKG----------------- 439
G WD P C A+ C VH +G
Sbjct: 2846 GLWDRSLPKCLAISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSH 2905
Query: 440 ----LVRCAHSPIG----------------EFTYKSSCAFSCEEGFELHGSTQLECTSQG 479
L C + G +F KS FSCE G +L GS + C G
Sbjct: 2906 WSGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNG 2965
Query: 480 QWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGH 539
W+ P C+ V C + P + S +F + +AC EG+ +G R C A G
Sbjct: 2966 SWSGLQPVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGT 3025
Query: 540 WSGLLPTC 547
W+G P C
Sbjct: 3026 WTGTAPDC 3033
Score = 179 bits (453), Expect = 9e-45
Identities = 116/393 (29%), Positives = 175/393 (44%), Gaps = 24/393 (6%)
Query: 162 TCKCDPGFSGLK--CEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSM 219
TC + +SGL+ CE V+C +P +G +V S + ++SS +C GY S +
Sbjct: 2960 TCLLNGSWSGLQPVCEA-VSCGNPGTPTNGMIVSSDGI---LFSSSVIYACWEGYKTSGL 3015
Query: 220 ETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGF--E 277
T C ++G W+ P C ++ C ANG Q F +N T ++ C G+ E
Sbjct: 3016 MTRHCTANGTWTGTAPDCTIISCGDPGTLANGI----QFGTDFTFNKTVSYQCNPGYVME 3071
Query: 278 LMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEE 337
+ + +++CT G W+ KP CKAV C QNG+V S +F + SS +++C +
Sbjct: 3072 AVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGS-----DFRWGSSISYSCMD 3126
Query: 338 GFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFS 397
G+ L A + C +G W +IP C C P G ++ SF Y S F
Sbjct: 3127 GYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRLS-----GKSFTYKSEVFFQ 3181
Query: 398 CEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSC 457
C+ F+L GS R C G W +PTC + P +S G + S+
Sbjct: 3182 CKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSSRG-YEVGSTV 3240
Query: 458 AFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCK 517
F C +G+ + GST C + W+ C C P ++ P FG
Sbjct: 3241 FFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTFGYTLV 3300
Query: 518 FACPEGWTL-NGSAARTCGATGHWSGLLPTCEA 549
+ C G+ L GS RTC A W+G P C++
Sbjct: 3301 YTCHPGFFLAGGSEHRTCKADMKWTGKSPVCKS 3333
Score = 166 bits (419), Expect = 8e-41
Identities = 105/362 (29%), Positives = 154/362 (42%), Gaps = 24/362 (6%)
Query: 200 FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPAC---NVVECDAVTNPANGFVECF 256
F+Y + SC +T C WS +P C N C PA+G
Sbjct: 2876 FTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGS---- 2931
Query: 257 QNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVR 316
+ F + F CE G +L G+ C +G+W +P C+AV+C P NG +
Sbjct: 2932 RLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMIV 2991
Query: 317 CSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERG 376
S F SS + C EG+ G CT G WT P CT +S + G
Sbjct: 2992 SSDG----ILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAP-----DCTIISCGDPG 3042
Query: 377 YMNCLPSASGSFRYGSSCEFSCEQGFVLKG--SKRLQCGPTGEWDNEKPTCEAVRCDAVH 434
+ F + + + C G+V++ S ++C G W+ KP C+AV C
Sbjct: 3043 TLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCP--- 3099
Query: 435 QPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCS 494
QPP V+ +F + SS ++SC +G++L S L C +G W E+P C V C
Sbjct: 3100 QPPP--VQNGTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCG 3157
Query: 495 SLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESN 554
+P + +S + + F C + L GS+ R C A G WSG+ PTC P +
Sbjct: 3158 DPGIPAEGRLS-GKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNT 3216
Query: 555 IP 556
P
Sbjct: 3217 CP 3218
Score = 154 bits (389), Expect = 2e-37
Identities = 113/390 (28%), Positives = 169/390 (43%), Gaps = 40/390 (10%)
Query: 176 QIVNCTALESPEHGSLVCSHPLGN-FSYNSSCSISCDRGY-LPSSME-TMQCMSSGEWS- 231
Q V+C ESP +GS GN F+ +S C G+ L SS + T C G WS
Sbjct: 2492 QAVSCGIPESPGNGSFT-----GNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSN 2546
Query: 232 -APIPACNVVECDAVTNPANGFVECFQNPGSF-PWNTTCTFDCEEGFELMGAQSLQCTSS 289
P C V C ++ + V GS + C G+ L G + L+C ++
Sbjct: 2547 KGKPPTCKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQAN 2606
Query: 290 GNWD--NEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFT-FKSSCNFTCEEGFMLQGPAQ 346
G W+ +E+P+C+ ++C ++ P NG+ G T + ++ FTC G+ L G
Sbjct: 2607 GTWNIGDERPSCRVISCGSLSFPPNGN------KIGTLTVYGATAIFTCNTGYTLVGSHV 2660
Query: 347 VECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKG 406
EC G W+ C A C + G+++ F Y + + C GF L G
Sbjct: 2661 RECLANGLWSGSETRCLAGHCGSPDPIVNGHIS-----GDGFSYRDTVVYQCNPGFRLVG 2715
Query: 407 SKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFE 466
+ C +W + P C + C P G + EF F+C G+
Sbjct: 2716 TSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNGS-----EFNLNDVVNFTCNTGYL 2770
Query: 467 LHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKI-NMSCSGEPVF------GTVCKFA 519
L G ++ +C S GQW+ +P+C+VV CS PG + N G+ F G +
Sbjct: 2771 LQGVSRAQCRSNGQWSSPLPTCRVVNCSD---PGFVENAIRHGQQNFPESFEYGMSILYH 2827
Query: 520 CPEGWTLNGSAARTCGATGHWSGLLPTCEA 549
C +G+ L GS+A TC A G W LP C A
Sbjct: 2828 CKKGFYLLGSSALTCMANGLWDRSLPKCLA 2857
Score = 108 bits (271), Expect = 1e-23
Identities = 111/436 (25%), Positives = 161/436 (36%), Gaps = 80/436 (18%)
Query: 199 NFSYNSSCSISCDRGYLPSSMETMQCMSSGE--WSAPIPACNVVECDA--VTNPANGFVE 254
+F C GY + + C S + + +P C +C A V ++G +
Sbjct: 2276 DFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEA-QCPANEVRTGSSGVIL 2334
Query: 255 CFQNPGSFPWNTTC-----------------TFDCEEGFELM-------GAQSLQCTSSG 290
PG++ + TC TF E+ F+ + G L SG
Sbjct: 2335 SPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQFDALEVFDGSSGQSPLLVVLSG 2394
Query: 291 N-----------------WDNEKPTCK--------AVTCRAVRQPQNGSVRCSHSPAGEF 325
N W + T K A C +NG + + AG
Sbjct: 2395 NHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAAPYCSLTHPLKNGGIL--NRTAG-- 2450
Query: 326 TFKSSCNFTCEEGFMLQGPAQVECTTQG----QWTQQIPVCEAFQCTALSNPERGYMNCL 381
S ++ C+ G+ + G + C QW P+C+A C +P G
Sbjct: 2451 AVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFT-- 2508
Query: 382 PSASGSFRYGSSCEFSCEQGFVLKGSKRLQ--CGPTGEWDNE--KPTCEAVRCDAVHQPP 437
F S + C +GF L+ S++ C G W N+ PTC+ V C ++
Sbjct: 2509 ---GNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQL 2565
Query: 438 KGLV--RCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWT--EEVPSCQVVKC 493
V R + E Y + SC G+ L G L C + G W +E PSC+V+ C
Sbjct: 2566 SEHVIWRLVSGSLNE--YGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISC 2623
Query: 494 SSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEA-PTE 552
SL+ P N V+G F C G+TL GS R C A G WSG C A
Sbjct: 2624 GSLSFPPNGN-KIGTLTVYGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCG 2682
Query: 553 SNIPLVAG-LSAAGLS 567
S P+V G +S G S
Sbjct: 2683 SPDPIVNGHISGDGFS 2698
Score = 54.3 bits (129), Expect = 3e-07
Identities = 84/430 (19%), Positives = 133/430 (30%), Gaps = 91/430 (21%)
Query: 200 FSYNSSCSISCDRGYLPSSMETMQCMSS----GEWSAPIPACNVV-ECDAVTNPANGFVE 254
F+ SC GY+ + C+ S W P P C C + +
Sbjct: 161 FNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCRAEGACGGTLRGTSSSIS 220
Query: 255 CFQNPGSFPWNTTCT-----------------FDCEEGFELMGAQSLQCTSSGNWDNEKP 297
P + N CT F EEG++ + + S P
Sbjct: 221 SPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYDFLEISGTEAPSIWLTGMNLP 280
Query: 298 TCKAVTCRAVRQPQNGSVRCSHSPAG---EFTFKSSCNFTCEEGFMLQGPAQVECTTQGQ 354
+ + +R +H G +F K + ML P++
Sbjct: 281 SPVISSKNWLRLHFTSD--SNHRRKGFNAQFQVKKAIELKSRGVKML--PSKDGSHKNSV 336
Query: 355 WTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGP 414
+Q + C PE G + S R G++ +FSCE +VL+GSK + C
Sbjct: 337 LSQGGVALVSDMCPDPGIPENGRR----AGSDFSRVGANVQFSCEDNYVLQGSKSITCQR 392
Query: 415 TGE----WDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCA------------ 458
E W + +P C A C + + P G++ + P+ ++ + C
Sbjct: 393 VTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPV-QYEDNAHCVWVITTTDPDKVI 451
Query: 459 ------FSCEEGFE-------------------LHGST---QLECTSQGQWTEEVPSCQV 490
F E G++ L GS+ + S W +
Sbjct: 452 KLAFEEFELERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSI 511
Query: 491 VKCSSLAVPGKINMSCSGEP-------------VFGTVCKFACPEGWTLNGSAARTCGAT 537
AV +I G+P + G F CP + L G TC
Sbjct: 512 GSPGFKAVYQEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQN 571
Query: 538 GHWSGLLPTC 547
WSG P+C
Sbjct: 572 NQWSGNKPSC 581
Score = 53.5 bits (127), Expect = 5e-07
Identities = 63/248 (25%), Positives = 91/248 (36%), Gaps = 39/248 (15%)
Query: 262 FPWNTTCTFDCEEGFELMGAQSLQCTSSGN----WDNEKPTCKAVTCRAVRQPQNGSVRC 317
F +T T+ C+ G++++ S+ C + WD P+C A C G V
Sbjct: 1581 FKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCNA-PCGGQYTGSEGVVLS 1639
Query: 318 SHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQW----TQQIPVCEAFQCTALSNP 373
+ P N+T + + E GQ+ T + E F T
Sbjct: 1640 PNYPH---------NYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAELFDGT----- 1685
Query: 374 ERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWD--NEKPTCEAVRCD 431
L S SGS G + + +L+ S + G P +C
Sbjct: 1686 -HAQARLLSSLSGSHS-GETLPLATSNQILLRFSAKSGASARGFHFVYQAVPRTSDTQCS 1743
Query: 432 AVHQPPKGLVRCAHSPIG-EFTYKSSCAFSCEEGFELHGSTQLECTS----QGQWTEEVP 486
+V +P G IG EF+ S F C G+ L GST L C S QW + +P
Sbjct: 1744 SVPEPRYG------RRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIP 1797
Query: 487 SCQVVKCS 494
SC VV CS
Sbjct: 1798 SC-VVPCS 1804
Score = 50.8 bits (120), Expect = 4e-06
Identities = 90/419 (21%), Positives = 137/419 (32%), Gaps = 97/419 (23%)
Query: 198 GNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQ 257
G+F S+ + SCD GY S E + C + +W+ +P+C+ + C +G V
Sbjct: 888 GDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDAL-CGGYIQGKSGTVLSPG 946
Query: 258 NPGSFPWNTTCTFDCE----EGFELM--------GAQSLQCTSSGNWDNEKPTCKAVTCR 305
P +P + CT+ E +G +++ L T G++ +P +
Sbjct: 947 FPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITEDGSF--SEPVARL---- 1000
Query: 306 AVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAF 365
GSV AG F NFT + F+ E + C+
Sbjct: 1001 ------TGSVLPHTIKAGLFG-----NFTAQLRFISDFSISYEGFNITFSEYDLEPCDDP 1049
Query: 366 QCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQC--GPTGEWDNEKP 423
A S F G S FSC G+ L+G+ +L C G W P
Sbjct: 1050 GVPAFSR----------RIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLP 1099
Query: 424 TCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAF--SCEEGFELHGSTQ--------- 472
C A C A + +G + + P + C + E G +H T+
Sbjct: 1100 RCVA-ECGASVKGNEGTLLSPNFP-SNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDT 1157
Query: 473 --------------------------LECTSQGQWTE--------------EVPSCQVVK 492
L TS W E S +VK
Sbjct: 1158 LKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLVK 1217
Query: 493 CSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTC--GATGHWSGLLPTCEA 549
C +P TV ++C G+ ++GS TC G W LP+C A
Sbjct: 1218 CEDPGIPNYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIA 1276
Score = 48.1 bits (113), Expect = 2e-05
Identities = 74/318 (23%), Positives = 117/318 (36%), Gaps = 72/318 (22%)
Query: 198 GNFSY------NSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANG 251
GNF Y NS SI Y ++E+ C+ G P NG
Sbjct: 842 GNFMYLLFTTDNSRSSIGFLIHYESVTLESDSCLDPGI------------------PVNG 883
Query: 252 FVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQ 311
++ G F +T TF C+ G+ L + L C + W++ P+C A+ C Q +
Sbjct: 884 H----RHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDAL-CGGYIQGK 938
Query: 312 NGSVRCSHSPAGEFTFKSSCNFTCE-----------EGFMLQGPAQ-VECTTQGQWTQQI 359
+G+V P + +C +T E F L+ + T G +++ +
Sbjct: 939 SGTVLSPGFP-DFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITEDGSFSEPV 997
Query: 360 PVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWD 419
+ T P + + R+ S S E GF + S E+D
Sbjct: 998 A-----RLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYE-GFNITFS---------EYD 1042
Query: 420 NEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQG 479
E CD P H +G+ S FSC G+ L G+T+L C G
Sbjct: 1043 LEP-------CDDPGVPAFSRRIGFHFGVGD-----SLTFSCFLGYRLEGATKLTCLGGG 1090
Query: 480 Q--WTEEVPSCQVVKCSS 495
+ W+ +P C V +C +
Sbjct: 1091 RRVWSAPLPRC-VAECGA 1107
Score = 47.0 bits (110), Expect = 5e-05
Identities = 79/392 (20%), Positives = 126/392 (32%), Gaps = 103/392 (26%)
Query: 199 NFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQN 258
+F + + + C + + C + +WS P+C V C ++G +
Sbjct: 543 SFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSC-VFSCFFNFTASSGIILSPNY 601
Query: 259 PGSFPWNTTCT-----------------FDCEEGFELMGAQS---LQCTSSGNWD-NEKP 297
P + N C FD E F+ + + T G + NE P
Sbjct: 602 PEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAVKDDGISDITVLGTFSGNEVP 661
Query: 298 TCKAVTCRAVRQPQN-----------------GSVRCSHSPA---------GEFTFKSSC 331
+ A + VR G C H P F SS
Sbjct: 662 SQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNEC-HDPGIPINGRRFGDRFLLGSSV 720
Query: 332 NFTCEEGFM-LQGPAQVECTTQG---QWTQQIPVCEAFQCTALSNPERGYMNCLPSASGS 387
+F C++GF+ QG + C Q W+ +P CEA C G + P G
Sbjct: 721 SFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEA-PCGGHLTASSGVI-LPPGWPGY 778
Query: 388 FRYGSSCEFSCE--------------QGFVLKGSKRLQCGPT------GEW--------- 418
++ CE+ E Q V + ++ GP GE+
Sbjct: 779 YKDSLHCEWIIEAKPGHSIKITFDRFQTEVNYDTLEVRDGPASSSPLIGEYHGTQAPQFL 838
Query: 419 -------------DNEKPTC------EAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAF 459
DN + + E+V ++ G+ H G+F +S+ F
Sbjct: 839 ISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSCLDPGIPVNGHRHGGDFGIRSTVTF 898
Query: 460 SCEEGFELHGSTQLECTSQGQWTEEVPSCQVV 491
SC+ G+ L L C QW +PSC +
Sbjct: 899 SCDPGYTLSDDEPLVCERNHQWNHALPSCDAL 930
Score = 46.6 bits (109), Expect = 7e-05
Identities = 48/228 (21%), Positives = 77/228 (33%), Gaps = 63/228 (27%)
Query: 388 FRYGSSCEFSCEQGFVLKGSKRLQC--GPTGE--WDNEKPTCEAVRCDAVHQPPKGLVRC 443
F+ GS+ + C+ G+ + + C G G+ WD P+C A C + +G+V
Sbjct: 1581 FKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCNAP-CGGQYTGSEGVVLS 1639
Query: 444 AHSP---------------------IGEFTYKSSCAFSCEEGFE-LHGSTQLECTSQGQW 481
+ P G+F Y + E F+ H +L + G
Sbjct: 1640 PNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAELFDGTHAQARLLSSLSGSH 1699
Query: 482 TEE-------------------------------VPSCQVVKCSSLAVPGKINMSCSGEP 510
+ E VP +CSS+ P + E
Sbjct: 1700 SGETLPLATSNQILLRFSAKSGASARGFHFVYQAVPRTSDTQCSSVPEP-RYGRRIGSEF 1758
Query: 511 VFGTVCKFACPEGWTLNGSAARTC----GATGHWSGLLPTCEAPTESN 554
G++ +F C G+ L GS A C A W+ +P+C P N
Sbjct: 1759 SAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCVVPCSGN 1806
Score = 43.1 bits (100), Expect = 7e-04
Identities = 88/444 (19%), Positives = 150/444 (33%), Gaps = 103/444 (23%)
Query: 177 IVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE--WSAPI 234
+V C P +G + G+F+ ++ SC+ GY T+ C+S W P+
Sbjct: 1215 LVKCEDPGIPNYGYRIRDE--GHFT-DTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPL 1271
Query: 235 PACNVVECDAVTNPA-NGFVECFQNPGSFPWNTTCT-----------------FDCEEGF 276
P+C + EC + A +G + P + N CT FD E
Sbjct: 1272 PSC-IAECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMAH 1330
Query: 277 ELMGA--------------------QSLQCT--------------SSGNWDNEKPTCKAV 302
+++ + + T S + + T A
Sbjct: 1331 DILKVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAA 1390
Query: 303 TCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQ---WTQQI 359
TC PQNG+ AG+ + F C+ G+ LQG A++ C W
Sbjct: 1391 TCNDPGMPQNGTRYGDSREAGD-----TVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDP 1445
Query: 360 PVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEF--SCEQGFVLK-GSKRLQCGPTG 416
P C A L+ P ++ P+ + G C++ FV+ K P+
Sbjct: 1446 PTCIAACGGNLTGPAGVILS--PNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSY 1503
Query: 417 E----WDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGF--ELHGS 470
+ ++ E + Q P+ + +S F +S S GF E
Sbjct: 1504 DFLHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLS---GFAIEFKEK 1560
Query: 471 TQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSA 530
+ C G ++ + + K+ G+ + C G+ + +
Sbjct: 1561 PREACFDPG---------NIMNGTRVGTDFKL----------GSTITYQCDSGYKILDPS 1601
Query: 531 ARTC--GATG--HWSGLLPTCEAP 550
+ TC GA G W +LP+C AP
Sbjct: 1602 SITCVIGADGKPSWDQVLPSCNAP 1625
Score = 43.1 bits (100), Expect = 7e-04
Identities = 56/236 (23%), Positives = 80/236 (33%), Gaps = 30/236 (12%)
Query: 200 FSYNSSCSISCDRGYLPSSMETMQCMSSG--EWSAPIPACNVVECDAVTNPANGFVECFQ 257
+ N S C+ GY + CM W+ P P C + C + G +
Sbjct: 1932 YMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLC-IATCGGTLSTLGGVILSPG 1990
Query: 258 NPGSFPWNTTCTFDCEEGFELMGA--QSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSV 315
PGS+P N CT+ GA Q L ++ N D + P G
Sbjct: 1991 FPGSYPNNLDCTWRISLPIG-YGAHIQFLNFSTEANHD----FLEIQNGPYHTSPMIGQF 2045
Query: 316 RCSHSPAG--EFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNP 373
+ PA T ++ +F + QG + Q Q P FQ
Sbjct: 2046 SGTDLPAALLSTTHETLIHFYSDHSQNRQG---FKLAYQAYELQNCPDPPPFQ------- 2095
Query: 374 ERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQC--GPTGEWDNEKPTCEA 427
GYM + + G S F C G++L G L C G W+ P C+A
Sbjct: 2096 -NGYM-----INSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDA 2145
Score = 41.6 bits (96), Expect = 0.002
Identities = 59/258 (22%), Positives = 93/258 (36%), Gaps = 36/258 (13%)
Query: 180 CTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMS----SGEWSAPIP 235
C+++ P +G + S FS S C+ GYL + C S +W+ IP
Sbjct: 1742 CSSVPEPRYGRRIGSE----FSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIP 1797
Query: 236 ACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFD--CEEGFELMGAQSLQCTSSGNWD 293
+C VV C G + P + N C + EG + Q + + NWD
Sbjct: 1798 SC-VVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQ-IQVISFATEQNWD 1855
Query: 294 NEKPTCKAVTCRAVRQPQNGSVRCSHSPA--GEFTFKSSCNFTCEEGFMLQGPAQVECTT 351
+ + V P+ GS + PA + + +F + G +E T
Sbjct: 1856 ----SLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAG-FHLEYKT 1910
Query: 352 QGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQ 411
G Q P A ++ +R +N + S F CE G+ L+G +
Sbjct: 1911 VGLAACQEP---ALPSNSIKIGDRYMVNDVLS------------FQCEPGYTLQGRSHIS 1955
Query: 412 C--GPTGEWDNEKPTCEA 427
C G W+ P C A
Sbjct: 1956 CMPGTVRRWNYPSPLCIA 1973
Score = 40.4 bits (93), Expect = 0.005
Identities = 54/262 (20%), Positives = 95/262 (36%), Gaps = 46/262 (17%)
Query: 199 NFSYNSSCSISCDRGYLPSSMETMQCMSSGE----WSAPIPACNVVECDAVTNPANGFVE 254
+F S+ + CD GY ++ C+ + W +P+CN C + G V
Sbjct: 1580 DFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCNA-PCGGQYTGSEGVVL 1638
Query: 255 CFQNPGSFPWNTTCTFDCE--EGFELMGAQSLQCTSSGN----WDNEKPTCKAVTCRAVR 308
P ++ C + + F + G + T+ + +D + ++
Sbjct: 1639 SPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAELFDGTHAQARLLS----- 1693
Query: 309 QPQNGSVRCSHSPAGEFTFKSSCN-----FTCEEGFMLQGPAQVECTTQGQWTQQIPVCE 363
S+ SHS GE ++ N F+ + G +G V Q +P
Sbjct: 1694 -----SLSGSHS--GETLPLATSNQILLRFSAKSGASARGFHFVY--------QAVPRTS 1738
Query: 364 AFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQC----GPTGEWD 419
QC+++ P G F GS F C G++L+GS L C +W+
Sbjct: 1739 DTQCSSVPEPRYGRR-----IGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWN 1793
Query: 420 NEKPTCEAVRCDAVHQPPKGLV 441
+ P+C V C +G +
Sbjct: 1794 DTIPSC-VVPCSGNFTQRRGTI 1814
Score = 34.3 bits (77), Expect = 0.34
Identities = 29/133 (21%), Positives = 53/133 (39%), Gaps = 7/133 (5%)
Query: 194 SHPLGNFSYNSSCSI--SCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANG 251
S PLG F+ N + + +L T + + + ++V+C+ P G
Sbjct: 1168 SRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLVKCEDPGIPNYG 1227
Query: 252 FVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN--WDNEKPTCKAVTCRAVRQ 309
+ ++ G F +T + C G+ + G+ +L C S WD P+C A +
Sbjct: 1228 YR--IRDEGHFT-DTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIAECGGQIHA 1284
Query: 310 PQNGSVRCSHSPA 322
+G + PA
Sbjct: 1285 ATSGRILSPGYPA 1297
Score = 34.3 bits (77), Expect = 0.34
Identities = 23/69 (33%), Positives = 33/69 (47%), Gaps = 3/69 (4%)
Query: 489 QVVKCSSL-AVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATG--HWSGLLP 545
Q+ KC AVP ++ + G K+ C G+TL G+ TC + + G LP
Sbjct: 2255 QLKKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLP 2314
Query: 546 TCEAPTESN 554
TCEA +N
Sbjct: 2315 TCEAQCPAN 2323
Score = 29.6 bits (65), Expect = 8.5
Identities = 15/45 (33%), Positives = 20/45 (44%), Gaps = 2/45 (4%)
Query: 513 GTVCKFACPEGWTLNGSAARTC--GATGHWSGLLPTCEAPTESNI 555
G F C G+ L G TC G +W+ P C+AP N+
Sbjct: 2107 GQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPCGYNV 2151
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 177 bits (450), Expect = 2e-44
Identities = 123/418 (29%), Positives = 173/418 (41%), Gaps = 29/418 (6%)
Query: 147 SCSGHGECVETINNYTCKCDPGFSGLKCE-QIVNCTALESPEHGSLVCSHPLGNFSYNSS 205
SC G + + TC+ + +SG + E +++C +P + +V S L ++SS
Sbjct: 2860 SCEA-GHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGL---VFSSS 2915
Query: 206 CSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWN 265
C GY + + + C +G W+ P C V+ C PANG + F +N
Sbjct: 2916 IVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANGL----RLGNDFRYN 2971
Query: 266 TTCTFDCEEGF--ELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAG 323
T T+ C G+ E L CT W+ KP CKA+ C+ NG V S
Sbjct: 2972 KTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGS----- 3026
Query: 324 EFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPS 383
+F + SS + C EG+ L PA C G WT ++P C C P RG
Sbjct: 3027 DFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRRE---- 3082
Query: 384 ASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTC---EAVRCDAVHQPPKGL 440
F Y SS FSC VL GS R C G W +P+C C P G+
Sbjct: 3083 -DRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGI 3141
Query: 441 VRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPG 500
+ + S+ F C++G+ L GST C W+ P C C P
Sbjct: 3142 QNNSQG----YQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPT 3197
Query: 501 KINMSCSGEPVFGTVCKFACPEGWTL-NGSAARTCGATGHWSGLLPTCEAPTESNIPL 557
N+ P G ++C EG++L GS RTC A G W+G P C S P+
Sbjct: 3198 HANVGALDLPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRPSGRPI 3255
Score = 153 bits (387), Expect = 4e-37
Identities = 94/379 (24%), Positives = 148/379 (39%), Gaps = 30/379 (7%)
Query: 180 CTALESPEHGSLVCSHPLGN------FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSA- 232
C + P+ S+ H + + + + CD GY + ++C ++G+WS
Sbjct: 2588 CVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLG 2647
Query: 233 -PIPACNVVECDAVTNPANGFVECFQNPGSFP-WNTTCTFDCEEGFELMGAQSLQCTSSG 290
P C ++ C + P NG G+ + T F C G+ L+G++ +C ++G
Sbjct: 2648 DSTPTCRIISCGELPIPPNG-----HRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANG 2702
Query: 291 NWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECT 350
W + C A C NG H ++++ S + C GF L G + C
Sbjct: 2703 LWSGSEVRCLAGHCGTPEPIVNG-----HINGENYSYRGSVVYQCNAGFRLIGMSVRICQ 2757
Query: 351 TQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRL 410
W+ + P C C +P M+ S+ G+ +SC L G+
Sbjct: 2758 QDHHWSGKTPFCVLVSCGHPGSPPHSQMS-----GDSYTVGAVVRYSCIGKRTLVGNSTR 2812
Query: 411 QCGPTGEWDNEKPTCEAVRCDAVHQP--PKGLVRCAHSPIGEFTYKSSCAFSCEEGFELH 468
CG G W P C P P +R S F + FSCE G L
Sbjct: 2813 MCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDS----FDPGTVMRFSCEAGHVLR 2868
Query: 469 GSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNG 528
GS++ C + G W+ P C V+ C + P + S VF + + C EG+ G
Sbjct: 2869 GSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATG 2928
Query: 529 SAARTCGATGHWSGLLPTC 547
+R C G W+G P C
Sbjct: 2929 LLSRHCSVNGTWTGSDPEC 2947
Score = 151 bits (381), Expect = 2e-36
Identities = 112/406 (27%), Positives = 161/406 (39%), Gaps = 43/406 (10%)
Query: 180 CTALESPEHGSLVCSHPLGNFSYNSSCSI--SCDRGYLPSSMETMQCMSSGE----WSAP 233
C+ +P HG + LG S SI C+ GY C + WS
Sbjct: 2468 CSLPRAPLHGFI-----LGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEA 2522
Query: 234 IPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELM-GAQ-SLQCTSSGN 291
IP C + C P NG V + T + C EG+ L GA+ + +C +G
Sbjct: 2523 IPLCQALSCGLPEAPKNGMV----FGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGL 2578
Query: 292 WDNEK--PTCKAVTCRAVRQPQNGSVRCSHSP-----AGEFTFKSSCNFTCEEGFMLQGP 344
W N P C VTC P S+ H ++ F++ C+ G+ G
Sbjct: 2579 WSNRNVPPQCVPVTC-----PDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQ 2633
Query: 345 AQVECTTQGQWT--QQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGF 402
+ C G+W+ P C C L P G+ S YG++ FSC G+
Sbjct: 2634 RVIRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSV-----YGATAIFSCNSGY 2688
Query: 403 VLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCE 462
L GS+ +C G W + C A C P+ +V H ++Y+ S + C
Sbjct: 2689 TLVGSRVRECMANGLWSGSEVRCLAGHCGT----PEPIVN-GHINGENYSYRGSVVYQCN 2743
Query: 463 EGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPE 522
GF L G + C W+ + P C +V C P MS V G V +++C
Sbjct: 2744 AGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHSQMSGDSYTV-GAVVRYSCIG 2802
Query: 523 GWTLNGSAARTCGATGHWSGLLPTCEAPTESNIPLVAGLSAAGLSL 568
TL G++ R CG GHW+G LP C T + G+ A G+ L
Sbjct: 2803 KRTLVGNSTRMCGLDGHWTGSLPHCSG-TSVGVCGDPGIPAHGIRL 2847
Score = 63.2 bits (152), Expect = 7e-10
Identities = 58/280 (20%), Positives = 100/280 (35%), Gaps = 42/280 (15%)
Query: 200 FSYNSSCSISCDRGYLPSSMETMQCMSSGE----WSAPIPACNVVE-CDAVTNPANGFVE 254
F+ SC+ G+ + C + E W P+P+C + C +G +
Sbjct: 155 FNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDACGGTLRGQSGIIS 214
Query: 255 CFQNPGSFPWNTTCT-----------------FDCEEGFELMGAQSLQCTSSGNWDN--- 294
P + N CT F E+G++ + + S W
Sbjct: 215 SPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGYDFLEVTGTE--GSSLWFTGAS 272
Query: 295 -EKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQG 353
P + + +G+ R + ++ K ++ + T+
Sbjct: 273 LPAPVISSKNWLRLHFTSDGNHR-QRGFSAQYQVKKQIELKSRGVKLMPSKDNSQKTSV- 330
Query: 354 QWTQQIPVCEAFQ-CTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQC 412
Q+ V + C PERG FR GSS +F+C +G+ L+GSKR+ C
Sbjct: 331 --LTQVGVSQGHNMCPDPGIPERG-----KRLGSDFRLGSSVQFTCNEGYDLQGSKRITC 383
Query: 413 GPTGE----WDNEKPTCEAVRCDAVHQPPKGLVRCAHSPI 448
+ W + +P C A CDA + P G++ + PI
Sbjct: 384 MKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPI 423
Score = 60.5 bits (145), Expect = 4e-09
Identities = 76/288 (26%), Positives = 108/288 (37%), Gaps = 48/288 (16%)
Query: 176 QIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE--WSAP 233
+++ C +P+ G V H G+F+ SS S SCD GY E + C+S W P
Sbjct: 1207 ELIKCEDPGTPKFGYKV--HDEGHFA-GSSVSFSCDPGYSLRGSEELLCLSGERRTWDRP 1263
Query: 234 IPACNVVECDA-VTNPANGFVECFQNPGSFPWNTTC--TFDCEEGFELMGAQSLQCTSSG 290
+P C V EC V +G V P + N C T + E G + G L +
Sbjct: 1264 LPTC-VAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTI-GLHFLVFDTEE 1321
Query: 291 N------WDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNF-TCEEGFMLQG 343
WD P V + + P + HS + S +F T ++GF +Q
Sbjct: 1322 VHDVLRIWDG--PVESGVLLKELSGP--ALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQ- 1376
Query: 344 PAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASG-SFRYGSSCEFSCEQGF 402
V A C P+ G S SG S+ G S F C+ G+
Sbjct: 1377 ---------------FSVSTATSCNDPGIPQNG------SRSGDSWEAGDSTVFQCDPGY 1415
Query: 403 VLKGSKRLQCGPTGE---WDNEKPTCEAVRCDAVHQPPKGLVRCAHSP 447
L+GS + C W PTC A C P G++ + P
Sbjct: 1416 ALQGSAEISCVKIENRFFWQPSPPTCIA-PCGGDLTGPSGVILSPNYP 1462
Score = 57.8 bits (138), Expect = 3e-08
Identities = 69/271 (25%), Positives = 99/271 (36%), Gaps = 30/271 (11%)
Query: 200 FSYNSSCSISCDRGYLPSSMETMQCMSSGE--WSAPIPACNVVECDAVTNPANGFVECFQ 257
F + + SC GY + C+ WS+P+P C V EC N G
Sbjct: 1055 FGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRC-VAECG---NSVTGTQGTLL 1110
Query: 258 NPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRC 317
+P +FP N +C + + +Q + +E K V N S R
Sbjct: 1111 SP-NFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEGDVLK------VYDGNNNSARL 1163
Query: 318 ----SHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNP 373
SHS T S+ + L E T++G + E +C P
Sbjct: 1164 LGVFSHSEMMGVTLNSTSS-----SLWLDFITDAENTSKG-FELHFSSFELIKCEDPGTP 1217
Query: 374 ERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQC--GPTGEWDNEKPTCEAVRCD 431
+ GY G F GSS FSC+ G+ L+GS+ L C G WD PTC A
Sbjct: 1218 KFGYK---VHDEGHFA-GSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAECGG 1273
Query: 432 AVHQPPKGLVRCAHSPIGEFTYKSSCAFSCE 462
V G V P + + +C ++ E
Sbjct: 1274 TVRGEVSGQVLSPGYP-APYEHNLNCIWTIE 1303
Score = 54.3 bits (129), Expect = 3e-07
Identities = 89/409 (21%), Positives = 144/409 (35%), Gaps = 79/409 (19%)
Query: 199 NFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQN 258
+F + + SCD GY S E ++C + +WS +P+C + C ++G +
Sbjct: 882 DFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEAL-CGGFIQGSSGTILSPGF 940
Query: 259 PGSFPWNTTC-----------------TFDCEEGFE----------------LMGAQSLQ 285
P +P N C TF E G + L G++
Sbjct: 941 PDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITENGSFTQPLRQLTGSRLPA 1000
Query: 286 CTSSGNWDNEKPTCKAVT--------------------CRAVRQPQNGSVRCSHSPAGEF 325
S+G + N + ++ C P S+R +F
Sbjct: 1001 PISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCEEPEVPAY-SIR----KGLQF 1055
Query: 326 TFKSSCNFTCEEGFMLQGPAQVECT--TQGQWTQQIPVCEAFQCTALSNPERGYMNCLPS 383
+ F+C G+ L+G A++ C + W+ +P C A +C N G L S
Sbjct: 1056 GVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVA-EC---GNSVTGTQGTLLS 1111
Query: 384 ASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRC 443
+ Y ++ E C + K +Q +E + D + + L
Sbjct: 1112 PNFPVNYNNNHE--CIYSIQTQPGKGIQLKARAFELSEGDVLKVY--DGNNNSARLLGVF 1167
Query: 444 AHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKIN 503
+HS + T S+ L T E TS+G + S +++KC P K
Sbjct: 1168 SHSEMMGVTLNST-----SSSLWLDFITDAENTSKG-FELHFSSFELIKCEDPGTP-KFG 1220
Query: 504 MSCSGEPVF-GTVCKFACPEGWTLNGSAARTC--GATGHWSGLLPTCEA 549
E F G+ F+C G++L GS C G W LPTC A
Sbjct: 1221 YKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVA 1269
Score = 48.9 bits (115), Expect = 1e-05
Identities = 65/269 (24%), Positives = 105/269 (39%), Gaps = 41/269 (15%)
Query: 257 QNPGSFPWNTTCTFDCEEGFELMGAQSLQC----TSSGNWDNEKPTCKAV-TCRAVRQPQ 311
Q +F + C GF L G L C +S WD P+C+A C + Q
Sbjct: 150 QQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDACGGTLRGQ 209
Query: 312 NGSVRCSHSPAGEFTFKSSCNFT--CEEG---------FMLQ-GPAQVECT-TQGQ--WT 356
+G + H P+ E+ + C +T E G F L+ G +E T T+G W
Sbjct: 210 SGIISSPHFPS-EYHNNADCTWTILAELGDTIALVFIDFQLEDGYDFLEVTGTEGSSLW- 267
Query: 357 QQIPVCEAFQCTALSNPERGYMNCLP---SASGSFRY-GSSCEFSCEQGFVLKGSKRLQC 412
F +L P N L ++ G+ R G S ++ ++ LK S+ ++
Sbjct: 268 --------FTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELK-SRGVKL 318
Query: 413 GPTGEWDNEKPTCEAVRCDAVHQ--PPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGS 470
P+ + + V H P G+ +F SS F+C EG++L GS
Sbjct: 319 MPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGYDLQGS 378
Query: 471 TQLECTSQGQ----WTEEVPSCQVVKCSS 495
++ C W++ P C+ C +
Sbjct: 379 KRITCMKVSDMFAAWSDHRPVCRARMCDA 407
Score = 48.1 bits (113), Expect = 2e-05
Identities = 50/228 (21%), Positives = 78/228 (34%), Gaps = 63/228 (27%)
Query: 389 RYGSSCEFSCEQGFVLKGSKRLQC--GPTGE--WDNEKPTCEAVRCDAVHQPPKGLVRCA 444
+ GSS + C G+ ++G+ L C GP G+ W+N +P C A C + G+V
Sbjct: 1575 KLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAP-CGGQYVGSDGVVLSP 1633
Query: 445 HSP---------------------IGEFTYKSSCAFSCEEGFELHGS-TQLECTSQGQWT 482
+ P G+F + + E + H ++L + G T
Sbjct: 1634 NYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSLSGSHT 1693
Query: 483 EE-------------------------------VPSCQVVKCSSLAVPGKINMSCSGEPV 511
E VP +CSS+ P + +
Sbjct: 1694 GESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSSVPEP-RYGKRLGSDFS 1752
Query: 512 FGTVCKFACPEGWTLNGSAARTC----GATGHWSGLLPTCEAPTESNI 555
G + +F C G+ L GS C GA W+ PTC P N+
Sbjct: 1753 VGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNL 1800
Score = 45.8 bits (107), Expect = 1e-04
Identities = 65/280 (23%), Positives = 102/280 (36%), Gaps = 48/280 (17%)
Query: 266 TTCTFDCEEGFELMGAQSLQCTSSGN----WDNEKPTCKAVTCRAVRQPQNGSVRCSHSP 321
++ T+ C G+E+ G +L C + W+N +P C A C +G V + P
Sbjct: 1578 SSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTA-PCGGQYVGSDGVVLSPNYP 1636
Query: 322 AGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNP------ER 375
N+T + + + GQ+ AF TAL++
Sbjct: 1637 Q---------NYTSGQICLYFVTVPKDYVVFGQF--------AFFHTALNDVVEVHDGHS 1679
Query: 376 GYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWD--NEKPTCEAVRCDAV 433
+ L S SGS G S + ++K S + G P A +C +V
Sbjct: 1680 QHSRLLSSLSGSHT-GESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSSV 1738
Query: 434 HQPPKGLVRCAHSPIG-EFTYKSSCAFSCEEGFELHGSTQLECT----SQGQWTEEVPSC 488
+P G +G +F+ + F C G+ L GS ++EC + QW P+C
Sbjct: 1739 PEPRYG------KRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTC 1792
Query: 489 QVVKCSSLAVPGKINMSCSGEP-----VFGTVCKFACPEG 523
VV C + + G P V K PEG
Sbjct: 1793 -VVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEG 1831
Score = 45.4 bits (106), Expect = 1e-04
Identities = 63/284 (22%), Positives = 91/284 (32%), Gaps = 59/284 (20%)
Query: 186 PEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE----WSAPIPACNVVE 241
PE G + S +F SS +C+ GY + + CM + WS P C
Sbjct: 349 PERGKRLGS----DFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARM 404
Query: 242 CDAVTNPANGFVECFQNPGSFPWNTTCT------------------FDCEEGFELMGAQS 283
CDA +G + P + N C FD E G++ +
Sbjct: 405 CDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYD-----T 459
Query: 284 LQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQG 343
L G ++K +T +V + V +H F S G L
Sbjct: 460 LTVGDGGQDGDQKTVLYILTGTSV---PDLIVSTNHQMWLLFQTDGS-------GSSLGF 509
Query: 344 PAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFV 403
A E QG C P G F +G + +F C+ F
Sbjct: 510 KASYEEIEQGS------------CGDPGIPAYGRRE-----GSRFHHGDTLKFECQPAFE 552
Query: 404 LKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSP 447
L G K + C +W +KP C C P G+V + P
Sbjct: 553 LVGQKAITCQKNNQWSAKKPGC-VFSCFFNFTSPSGVVLSPNYP 595
Score = 41.6 bits (96), Expect = 0.002
Identities = 69/292 (23%), Positives = 100/292 (34%), Gaps = 52/292 (17%)
Query: 203 NSSCSISCDRGYLPSSMETMQCMSSG--EWSAPIPACNVVECDAVTNPANGFVECFQNPG 260
N S C+ GY + CM W+ P P C + +C G + PG
Sbjct: 1928 NDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLC-IAQCGGTVEEMEGVILSPGFPG 1986
Query: 261 SFPWNTTCTFDCEEGFEL---MGA--QSLQCTSSGNWD------NEKPTCKAVTCRAVRQ 309
++P N DC L GA Q L ++ N D T + + + +
Sbjct: 1987 NYPSN----MDCSWKIALPVGFGAHIQFLNFSTEPNHDYIEIRNGPYETSRMMGRFSGSE 2042
Query: 310 PQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPA-----QVECTTQGQWTQQI----- 359
+ + SH F S N GF L+ Q+ +G ++
Sbjct: 2043 LPSSLLSTSHETTVYFHSDHSQN---RPGFKLEYQDLTYSHQISSFLRGFDLSELERTNS 2099
Query: 360 -------------PVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKG 406
P CEA++ +PE + N + +G + G S F C G+ L G
Sbjct: 2100 TPPVAASYVWDLDPGCEAYELQECPDPEP-FANGIVRGAG-YNVGQSVTFECLPGYQLTG 2157
Query: 407 SKRLQC--GPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSS 456
L C G WD+ P CE V C G V +SP Y SS
Sbjct: 2158 HPVLTCQHGTNRNWDHPLPKCE-VPCGGNITSSNGTV---YSPGFPSPYSSS 2205
Score = 40.0 bits (92), Expect = 0.006
Identities = 40/149 (26%), Positives = 58/149 (38%), Gaps = 20/149 (13%)
Query: 187 EHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVT 246
E+ L SH + +F D L + T +S W P C E
Sbjct: 2072 EYQDLTYSHQISSFLRGF------DLSELERTNSTPPVAASYVWDLD-PGCEAYELQECP 2124
Query: 247 NP---ANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCT--SSGNWDNEKPTCKA 301
+P ANG V + + TF+C G++L G L C ++ NWD+ P C+
Sbjct: 2125 DPEPFANGIVR----GAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCE- 2179
Query: 302 VTCRAVRQPQNGSVRCSHSPAGEFTFKSS 330
V C NG+V +SP + SS
Sbjct: 2180 VPCGGNITSSNGTV---YSPGFPSPYSSS 2205
Score = 36.6 bits (83), Expect = 0.069
Identities = 64/293 (21%), Positives = 101/293 (34%), Gaps = 70/293 (23%)
Query: 234 IPACNVVECDAVTNPANGFVECFQNPGS-FPWNTTCTFDCEEGFELMGAQSLQCT----S 288
+P + +C +V P G + GS F F+C G+ L G+ ++C +
Sbjct: 1727 VPRTSATQCSSVPEPRYG-----KRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGA 1781
Query: 289 SGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCN----FTCEEGFMLQGP 344
W+ PTC V C + G++ SP + +S N EG +Q
Sbjct: 1782 LAQWNVSAPTC-VVPCGGNLTERRGTIL---SPGFPEPYLNSLNCVWKIVVPEGAGIQIQ 1837
Query: 345 AQVECTTQGQW---------TQQIPVCEAFQCT---ALSNPERG------YMNCLPSASG 386
V T+ W + + +F T AL N Y + SA+G
Sbjct: 1838 V-VSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAG 1896
Query: 387 -SFRYG----SSC----------------------EFSCEQGFVLKGSKRLQC--GPTGE 417
Y SSC F CE G+ L+G + C G
Sbjct: 1897 FHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRR 1956
Query: 418 WDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAF--SCEEGFELH 468
W+ P C A +C + +G++ P G + C++ + GF H
Sbjct: 1957 WNYPPPLCIA-QCGGTVEEMEGVILSPGFP-GNYPSNMDCSWKIALPVGFGAH 2007
Score = 34.7 bits (78), Expect = 0.26
Identities = 24/78 (30%), Positives = 33/78 (42%), Gaps = 11/78 (14%)
Query: 418 WDNEKPTCEAVRCDAVHQPP---KGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLE 474
WD + P CEA P G+VR A +G+ S F C G++L G L
Sbjct: 2109 WDLD-PGCEAYELQECPDPEPFANGIVRGAGYNVGQ-----SVTFECLPGYQLTGHPVLT 2162
Query: 475 CT--SQGQWTEEVPSCQV 490
C + W +P C+V
Sbjct: 2163 CQHGTNRNWDHPLPKCEV 2180
Score = 33.1 bits (74), Expect = 0.77
Identities = 17/45 (37%), Positives = 19/45 (42%), Gaps = 2/45 (4%)
Query: 513 GTVCKFACPEGWTLNGSAARTC--GATGHWSGLLPTCEAPTESNI 555
G F C G+ L G TC G +W LP CE P NI
Sbjct: 2142 GQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNI 2186
>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
isoform 2 [Homo sapiens]
Length = 1033
Score = 159 bits (401), Expect = 9e-39
Identities = 129/453 (28%), Positives = 196/453 (43%), Gaps = 48/453 (10%)
Query: 140 TAAC-TNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPE----HGSLVCS 194
T AC TN S +G+ + C+ + + + V+ LE P H S
Sbjct: 115 TFACKTNFSMNGN-------KSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTS 167
Query: 195 HPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVE 254
+G+ + S + SC+ GYL + + C+SSG+WSA P C C ++ NG V
Sbjct: 168 ENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKV- 226
Query: 255 CFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQ 311
+ P T F C+EG+ L G S +C +G W + P C+ + C +
Sbjct: 227 --KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPIL 283
Query: 312 NGSVRCSHSPAGEFTFKSSCNFTC----EEG--FMLQGPAQVECTTQ----GQWTQQIPV 361
NG R + ++ S +TC EEG F+L G + + CT G W+ P
Sbjct: 284 NG--RHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPR 341
Query: 362 CE----AFQCTALSNPE--RGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPT 415
CE A QC +P+ RG M + + Y + F+C GF LKGSK+++C
Sbjct: 342 CELSTSAVQC---PHPQILRGRM--VSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQ 396
Query: 416 GEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLEC 475
G W+ P CE C A G H + F +S +SC G+ L G ++C
Sbjct: 397 GTWEPSAPVCEK-ECQAPPNILNGQKEDRH--MVRFDPGTSIKYSCNPGYVLVGEESIQC 453
Query: 476 TSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCG 535
TS+G WT VP C+V C + G+ ++ +C EG+ L+GS + C
Sbjct: 454 TSEGVWTPPVPQCKVAACEA---TGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQ 510
Query: 536 ATGHWSGLLPTCEAPTESNIPLVAGLSAAGLSL 568
T W + C+ T P++ + G SL
Sbjct: 511 GTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSL 543
Score = 148 bits (374), Expect = 1e-35
Identities = 123/465 (26%), Positives = 183/465 (39%), Gaps = 110/465 (23%)
Query: 197 LGNFSYNSSCSISCDRG------YLPSSMETMQCMSS----GEWSAPIPACNV----VEC 242
L +F Y ++ + +C+ G + T++C S+ G WS P P C + V+C
Sbjct: 543 LEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQC 602
Query: 243 DAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAV 302
V + ANG+ + F +N T TF C GF L G+ ++C + WD E P C+
Sbjct: 603 SHV-HIANGYKISGKEAPYF-YNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKE 660
Query: 303 TCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVEC--TTQGQWTQQIP 360
TC+ VRQ PAG N +C++G+ L G A C G W ++IP
Sbjct: 661 TCQHVRQ------SLQELPAGSRV--ELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIP 712
Query: 361 VCEAFQC----TALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPT- 415
+C+ C ++ G M + +F YG+ + C+QGF L G K+LQC
Sbjct: 713 LCKVIHCHPPPVIVNGKHTGMM------AENFLYGNEVSYECDQGFYLLGEKKLQCRSDS 766
Query: 416 ---GEWDNEKPTC----------------------------------------------E 426
G W P C
Sbjct: 767 KGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSR 826
Query: 427 AVRCDAVHQPPKGLVRC-----------AHSPIGEFTYKSSCAFS--------CEEGFEL 467
+RC + G+ C +P G T + FS C++G+ L
Sbjct: 827 VIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLL 886
Query: 468 HGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPV--FGTVCKFACPEGWT 525
G L CT +G W++ P C+ V CSS A I + +G V C +G+
Sbjct: 887 VGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYM 946
Query: 526 LNGSAARTCGATGHWSGLLPTCEAPTESNIPLVAGLSAAGLSLLT 570
L GS C + W+ L C + S P++ G+ AAGL LLT
Sbjct: 947 LEGSPQSQCQSDHQWNPPLAVCR--SRSLAPVLCGI-AAGLILLT 988
Score = 148 bits (373), Expect = 2e-35
Identities = 105/375 (28%), Positives = 163/375 (43%), Gaps = 51/375 (13%)
Query: 200 FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDA-----VTNPANGFVE 254
F +S SC+ GY+ E++QC S G W+ P+P C V C+A +T P + FV
Sbjct: 429 FDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVR 488
Query: 255 CFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGS 314
N C EG++L G+ +C + W E CK +TC NG+
Sbjct: 489 PDVNS-----------SCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGA 537
Query: 315 VRCSHSPAGEFTFKSSCNFTCEEG------FMLQGPAQVECTT----QGQWTQQIPVCE- 363
+ S +F + ++ +TC G F L G + + CT+ +G W+ P+C+
Sbjct: 538 --HTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKL 595
Query: 364 ---AFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDN 420
A QC+ + + GY + + Y + F C GF LKGS +++C WD
Sbjct: 596 SLLAVQCSHV-HIANGYK--ISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDP 652
Query: 421 EKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLEC--TSQ 478
E P CE C V Q + L P G + SC++G++L G C
Sbjct: 653 EIPVCEKETCQHVRQSLQEL------PAGSRVELVNT--SCQDGYQLTGHAYQMCQDAEN 704
Query: 479 GQWTEEVPSCQVVKC--SSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGA 536
G W +++P C+V+ C + V GK + ++G + C +G+ L G C +
Sbjct: 705 GIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRS 764
Query: 537 T----GHWSGLLPTC 547
G WSG P C
Sbjct: 765 DSKGHGSWSGPSPQC 779
Score = 115 bits (289), Expect = 9e-26
Identities = 95/343 (27%), Positives = 140/343 (40%), Gaps = 44/343 (12%)
Query: 240 VECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSS----GNWDNE 295
+ C + NG + + P + T + C F L+G +SL C + G WD
Sbjct: 21 ISCGSPPPILNGRISYYSTPIAV--GTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKP 78
Query: 296 KPTC----KAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTT 351
P C K +C P +R S + S F C+ F + G V C
Sbjct: 79 APKCEYFNKYSSCPEPIVPGGYKIRGSTP----YRHGDSVTFACKTNFSMNGNKSVWCQA 134
Query: 352 QGQW-TQQIPVCEA---FQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGS 407
W ++P C + +C AL G+ GS G S +SCE G++L G
Sbjct: 135 NNMWGPTRLPTCVSVFPLECPALPMIHNGHHTS--ENVGSIAPGLSVTYSCESGYLLVGE 192
Query: 408 KRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFEL 467
K + C +G+W PTCE RC ++ + P G V+ PI + F C+EG+ L
Sbjct: 193 KIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVK--EPPI--LRVGVTANFFCDEGYRL 248
Query: 468 HGSTQLECTSQGQ---WTEEVPSCQVVKCSSLAVPGKINMSCSGEPV----FGTVCKFAC 520
G C GQ WT ++P C+ + C S P +N G + +G++ + C
Sbjct: 249 QGPPSSRCVIAGQGVAWT-KMPVCEEIFCPS--PPPILNGRHIGNSLANVSYGSIVTYTC 305
Query: 521 ---PE---GWTLNGSAARTCGA----TGHWSGLLPTCEAPTES 553
PE + L G + C TG WSG P CE T +
Sbjct: 306 DPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSA 348
Score = 33.5 bits (75), Expect = 0.59
Identities = 11/42 (26%), Positives = 20/42 (47%)
Query: 196 PLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPAC 237
P + Y + ++ C+ GY+ QC S +W+ P+ C
Sbjct: 927 PRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVC 968
>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
isoform 1 [Homo sapiens]
Length = 1092
Score = 159 bits (401), Expect = 9e-39
Identities = 129/453 (28%), Positives = 196/453 (43%), Gaps = 48/453 (10%)
Query: 140 TAAC-TNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPE----HGSLVCS 194
T AC TN S +G+ + C+ + + + V+ LE P H S
Sbjct: 115 TFACKTNFSMNGN-------KSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTS 167
Query: 195 HPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVE 254
+G+ + S + SC+ GYL + + C+SSG+WSA P C C ++ NG V
Sbjct: 168 ENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKV- 226
Query: 255 CFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQ 311
+ P T F C+EG+ L G S +C +G W + P C+ + C +
Sbjct: 227 --KEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAW-TKMPVCEEIFCPSPPPIL 283
Query: 312 NGSVRCSHSPAGEFTFKSSCNFTC----EEG--FMLQGPAQVECTTQ----GQWTQQIPV 361
NG R + ++ S +TC EEG F+L G + + CT G W+ P
Sbjct: 284 NG--RHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPR 341
Query: 362 CE----AFQCTALSNPE--RGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPT 415
CE A QC +P+ RG M + + Y + F+C GF LKGSK+++C
Sbjct: 342 CELSTSAVQC---PHPQILRGRM--VSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQ 396
Query: 416 GEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLEC 475
G W+ P CE C A G H + F +S +SC G+ L G ++C
Sbjct: 397 GTWEPSAPVCEK-ECQAPPNILNGQKEDRH--MVRFDPGTSIKYSCNPGYVLVGEESIQC 453
Query: 476 TSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCG 535
TS+G WT VP C+V C + G+ ++ +C EG+ L+GS + C
Sbjct: 454 TSEGVWTPPVPQCKVAACEA---TGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQ 510
Query: 536 ATGHWSGLLPTCEAPTESNIPLVAGLSAAGLSL 568
T W + C+ T P++ + G SL
Sbjct: 511 GTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSL 543
Score = 149 bits (375), Expect = 1e-35
Identities = 122/442 (27%), Positives = 183/442 (41%), Gaps = 54/442 (12%)
Query: 162 TCKCDPGFSGLKCEQIVNCTALESPEHGSLVCS-------------HPLGN---FSYNSS 205
T KC GF+ LK + C A + + VC H GN F +
Sbjct: 627 TFKCYSGFT-LKGSSQIRCKADNTWDPEIPVCEKGCQSPPGLHHGRHTGGNTVFFVSGMT 685
Query: 206 CSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTN-----PANGFVECFQNPG 260
+CD GYL +++ CM SG WS P C C V PA VE
Sbjct: 686 VDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEET-CQHVRQSLQELPAGSRVELV---- 740
Query: 261 SFPWNTTCTFDCEEGFELMGA--QSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCS 318
NT+C ++G++L G Q Q +G W + P CK + C NG + +
Sbjct: 741 ----NTSC----QDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNG--KHT 790
Query: 319 HSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQ----GQWTQQIPVC-EAFQCTALSNP 373
A F + + ++ C++GF L G +++C + G W+ P C + T NP
Sbjct: 791 GMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNP 850
Query: 374 ERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTC---EAVRC 430
E + L ++ + C GF++ GS+ ++C W PTC + C
Sbjct: 851 EVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGC 910
Query: 431 DAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQV 490
+ P G I F+ S +SC++G+ L G L CT +G W++ P C+
Sbjct: 911 PPPPKTPNG--NHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKE 968
Query: 491 VKCSSLAVPGKINMSCSGEPV--FGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCE 548
V CSS A I + +G V C +G+ L GS C + W+ L C
Sbjct: 969 VNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCR 1028
Query: 549 APTESNIPLVAGLSAAGLSLLT 570
+ S P++ G+ AAGL LLT
Sbjct: 1029 --SRSLAPVLCGI-AAGLILLT 1047
Score = 148 bits (373), Expect = 2e-35
Identities = 111/425 (26%), Positives = 170/425 (40%), Gaps = 92/425 (21%)
Query: 200 FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDA-----VTNPANGFV- 253
F +S SC+ GY+ E++QC S G W+ P+P C V C+A +T P + FV
Sbjct: 429 FDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVR 488
Query: 254 --------ECFQNPGS-----------------------------------------FPW 264
E ++ GS FP+
Sbjct: 489 PDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPY 548
Query: 265 NTTCTFDCEEG------FELMGAQSLQCTSS----GNWDNEKPTCK----AVTCRAVRQP 310
TT T+ C G F L+G +++CTS+ G W P CK AV C V
Sbjct: 549 GTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIA 608
Query: 311 QNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTAL 370
+ +P + + + F C GF L+G +Q+ C W +IPVCE
Sbjct: 609 NGYKISGKEAP---YFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEK---GCQ 662
Query: 371 SNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRC 430
S P + + F G + +++C+ G++L G+K + C P+G W P CE C
Sbjct: 663 SPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEET-C 721
Query: 431 DAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLEC--TSQGQWTEEVPSC 488
V Q + L P G + SC++G++L G C G W +++P C
Sbjct: 722 QHVRQSLQEL------PAGSRVELVNT--SCQDGYQLTGHAYQMCQDAENGIWFKKIPLC 773
Query: 489 QVVKC--SSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGAT----GHWSG 542
+V+ C + V GK + ++G + C +G+ L G C + G WSG
Sbjct: 774 KVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSG 833
Query: 543 LLPTC 547
P C
Sbjct: 834 PSPQC 838
Score = 115 bits (289), Expect = 9e-26
Identities = 95/343 (27%), Positives = 140/343 (40%), Gaps = 44/343 (12%)
Query: 240 VECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSS----GNWDNE 295
+ C + NG + + P + T + C F L+G +SL C + G WD
Sbjct: 21 ISCGSPPPILNGRISYYSTPIAV--GTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKP 78
Query: 296 KPTC----KAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTT 351
P C K +C P +R S + S F C+ F + G V C
Sbjct: 79 APKCEYFNKYSSCPEPIVPGGYKIRGSTP----YRHGDSVTFACKTNFSMNGNKSVWCQA 134
Query: 352 QGQW-TQQIPVCEA---FQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGS 407
W ++P C + +C AL G+ GS G S +SCE G++L G
Sbjct: 135 NNMWGPTRLPTCVSVFPLECPALPMIHNGHHTS--ENVGSIAPGLSVTYSCESGYLLVGE 192
Query: 408 KRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFEL 467
K + C +G+W PTCE RC ++ + P G V+ PI + F C+EG+ L
Sbjct: 193 KIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVK--EPPI--LRVGVTANFFCDEGYRL 248
Query: 468 HGSTQLECTSQGQ---WTEEVPSCQVVKCSSLAVPGKINMSCSGEPV----FGTVCKFAC 520
G C GQ WT ++P C+ + C S P +N G + +G++ + C
Sbjct: 249 QGPPSSRCVIAGQGVAWT-KMPVCEEIFCPS--PPPILNGRHIGNSLANVSYGSIVTYTC 305
Query: 521 ---PE---GWTLNGSAARTCGA----TGHWSGLLPTCEAPTES 553
PE + L G + C TG WSG P CE T +
Sbjct: 306 DPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSA 348
>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
Length = 2489
Score = 155 bits (391), Expect = 1e-37
Identities = 122/446 (27%), Positives = 182/446 (40%), Gaps = 48/446 (10%)
Query: 147 SCSGHGECVETIN-----NYTCKCDPGFSGL------KCEQIVNCTALESPEHGSLVC-S 194
+C H + T N C DP +G+ +CE V ++PE +
Sbjct: 1799 TCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPT 1858
Query: 195 HPLGNFSY--NSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGF 252
P+ +F + +S + C GY M ++ C+ + WS+ C C P NG
Sbjct: 1859 IPINDFEFPVGTSLNYECRPGYF-GKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGM 1917
Query: 253 VECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQ 309
V + + +T + C EGF L+G+ S C SGN WD + P C+ ++C
Sbjct: 1918 VHINTDT---QFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPT 1974
Query: 310 PQNGSV----RCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQ----GQWTQQIPV 361
NG R S T++ E+ F L G + CT++ G W+ P
Sbjct: 1975 ISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPR 2034
Query: 362 C-EAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDN 420
C +CTA PE +P F F C+ GFV+ GS +QC G W
Sbjct: 2035 CISTNKCTA---PEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGP 2091
Query: 421 EKPTCEAVRCDAVHQPPKGLVRCAH--SPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQ 478
+ P C V QPP ++ H S F+ +SCE ++L G+ L CT Q
Sbjct: 2092 KLP-----HCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQ 2146
Query: 479 GQWTEEVPSCQVVKCSSL--AVP-GKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTC- 534
G W+ E P C V C +P G++ + + + G F C EG+ L G +A C
Sbjct: 2147 GDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQ--LGAKVSFVCDEGFRLKGRSASHCV 2204
Query: 535 --GATGHWSGLLPTCEAPTESNIPLV 558
G W+ +P CE N P +
Sbjct: 2205 LAGMKALWNSSVPVCEQIFCPNPPAI 2230
Score = 141 bits (355), Expect = 2e-33
Identities = 109/400 (27%), Positives = 165/400 (41%), Gaps = 44/400 (11%)
Query: 179 NCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE---WSAPIP 235
+C P +G + H + + S + SC G+ + +C+ SG WS P
Sbjct: 1453 SCKTPPDPVNGMV---HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPP 1509
Query: 236 ACNVVECDAVTNPANG-FVECFQNPGSFPWNTTCTFDCEEG------FELMGAQSLQCTS 288
C + C ANG F+ N +F + + T+ C G FEL+G S+ CTS
Sbjct: 1510 ICQRIPCGLPPTIANGDFIST--NRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTS 1567
Query: 289 S----GNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGP 344
+ G W P C +NG + + F+ F C+ GF+++GP
Sbjct: 1568 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGP 1625
Query: 345 AQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVL 404
+V+C +W ++P C PE + PS +F G +SCE G+ L
Sbjct: 1626 RRVKCQALNKWEPELPSCSR---VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDL 1682
Query: 405 KGSKRLQCGPTGEWDNEKPTCEAVRC-DAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEE 463
+G+ L C P G+W E P C C D + Q P G V P+ + +F C+E
Sbjct: 1683 RGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL---FPL-NLQLGAKVSFVCDE 1738
Query: 464 GFELHGSTQLECTSQGQ---WTEEVPSCQVVKCSS--LAVPGKINMSCSGEPVFGTVCKF 518
GF L GS+ C G W VP C+ + C + + G+ + SG+ +G +
Sbjct: 1739 GFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISY 1798
Query: 519 AC----PEGWTLN--GSAARTCGATGH----WSGLLPTCE 548
C G T N G + C + H WS P CE
Sbjct: 1799 TCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCE 1838
Score = 135 bits (339), Expect = 1e-31
Identities = 118/450 (26%), Positives = 180/450 (40%), Gaps = 72/450 (16%)
Query: 155 VETINNYTCKCDPGFSGLKCEQIV----------------NCTALESPEHGSLVCSHPLG 198
+ T NY C+ PG+SG I +C P +G + H +
Sbjct: 65 IGTYLNYECR--PGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMV---HVIK 119
Query: 199 NFSYNSSCSISCDRGYLPSSMETMQCMSSGE---WSAPIPACNVVECDAVTNPANG-FVE 254
+ S SC +GY + C+ SG+ W P C+ + C NG F+
Sbjct: 120 GIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIS 179
Query: 255 CFQNPGSFPWNTTCTFDCEEG------FELMGAQSLQCTSS----GNWDNEKPTCKAVTC 304
N +F + + T+ C G FEL+G S+ CTS+ G W P C
Sbjct: 180 T--NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 237
Query: 305 RAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEA 364
+NG + + F+ F C+ GF+++GP +V+C +W ++P C
Sbjct: 238 CTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR 295
Query: 365 FQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPT 424
P+ + +F G +SCE G+ L+G+ ++C P G+W PT
Sbjct: 296 ---VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPT 352
Query: 425 CEAVRC-DAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ--- 480
CE C D + Q G V P+ + F C+EGF+L GS+ C G
Sbjct: 353 CEVKSCDDFMGQLLNGRVL---FPV-NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL 408
Query: 481 WTEEVPSCQVVKCSSLAVPGKINMSCSGEPV----FGTVCKFAC---PEGWT---LNGSA 530
W VP C+ + C S P N +G+P+ FG + C P+ T L G +
Sbjct: 409 WNSSVPVCEQIFCPS--PPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGES 466
Query: 531 ARTCGA----TGHWS------GLLPTCEAP 550
C + G WS G+L C+AP
Sbjct: 467 TIRCTSDPQGNGVWSSPAPRCGILGHCQAP 496
Score = 133 bits (335), Expect = 4e-31
Identities = 101/398 (25%), Positives = 156/398 (39%), Gaps = 31/398 (7%)
Query: 200 FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNP 259
F+ C G++ T+QC ++G W +P C+ V C +G +
Sbjct: 2059 FTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV-CQPPPEILHG-EHTLSHQ 2116
Query: 260 GSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRA-VRQPQNGSVRCS 318
+F + CE ++L GA SL CT G+W E P C +C + Q +G V
Sbjct: 2117 DNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLP 2176
Query: 319 HSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQ---WTQQIPVCEAFQCTALSNPER 375
+ + +F C+EGF L+G + C G W +PVCE C
Sbjct: 2177 LN----LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILN 2232
Query: 376 GYMNCLPSASGSFRYGSSCEFSCE------QGFVLKGSKRLQCGP----TGEWDNEKPTC 425
G P G YG ++C+ F L G ++C G W + P C
Sbjct: 2233 GRHTGTPF--GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRC 2290
Query: 426 EAVRCDAVHQPPKGLVRCAH---SPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWT 482
E A PPK ++ H + + + ++ C+ G+ L G + CT QG W+
Sbjct: 2291 ELSVPAACPHPPK--IQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWS 2348
Query: 483 EEVPSCQVVKCSSLAVPGKINMSCSGEPV--FGTVCKFACPEGWTLNGSAARTCGATGHW 540
+ C+ V CS I+ + V +G C +G+TL GS C A W
Sbjct: 2349 QLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRW 2408
Query: 541 SGLLPTCEAPTESNIPLVAGLSAAGLSLLTLAPFLLWL 578
L C + T L+ G + + + L FL W+
Sbjct: 2409 DPPLAKCTSRTHD--ALIVGTLSGTIFFILLIIFLSWI 2444
Score = 132 bits (331), Expect = 1e-30
Identities = 110/410 (26%), Positives = 169/410 (41%), Gaps = 54/410 (13%)
Query: 179 NCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE---WSAPIP 235
+C P +G + H + + S + SC G+ + +C+ SG WS P
Sbjct: 553 SCKTPPDPVNGMV---HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPP 609
Query: 236 ACNVVECDAVTNPANG-FVECFQNPGSFPWNTTCTFDCEEG------FELMGAQSLQCTS 288
C + C ANG F+ N +F + + T+ C G FEL+G S+ CTS
Sbjct: 610 ICQRIPCGLPPTIANGDFIST--NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 667
Query: 289 S----GNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGP 344
+ G W P C +NG + + F+ F C+ GF+++GP
Sbjct: 668 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGP 725
Query: 345 AQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVL 404
+V+C +W ++P C P+ + +F G +SCE G+ L
Sbjct: 726 RRVKCQALNKWEPELPSCSR---VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDL 782
Query: 405 KGSKRLQCGPTGEWDNEKPTCEAVRC-DAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEE 463
+G+ ++C P G+W PTCE C D + Q G V P+ + F C+E
Sbjct: 783 RGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL---FPV-NLQLGAKVDFVCDE 838
Query: 464 GFELHGSTQLECTSQGQ---WTEEVPSCQVVKCSSLAVPGKINMSCSGEPV----FGTVC 516
GF+L GS+ C G W VP C+ + C S P N +G+P+ FG
Sbjct: 839 GFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPS--PPVIPNGRHTGKPLEVFPFGKTV 896
Query: 517 KFAC---PEGWT---LNGSAARTCGA----TGHWS------GLLPTCEAP 550
+ C P+ T L G + C + G WS G+L C+AP
Sbjct: 897 NYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAP 946
Score = 132 bits (331), Expect = 1e-30
Identities = 110/410 (26%), Positives = 169/410 (41%), Gaps = 54/410 (13%)
Query: 179 NCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE---WSAPIP 235
+C P +G + H + + S + SC G+ + +C+ SG WS P
Sbjct: 1003 SCKTPPDPVNGMV---HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPP 1059
Query: 236 ACNVVECDAVTNPANG-FVECFQNPGSFPWNTTCTFDCEEG------FELMGAQSLQCTS 288
C + C ANG F+ N +F + + T+ C G FEL+G S+ CTS
Sbjct: 1060 ICQRIPCGLPPTIANGDFIST--NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 1117
Query: 289 S----GNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGP 344
+ G W P C +NG + + F+ F C+ GF+++GP
Sbjct: 1118 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGP 1175
Query: 345 AQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVL 404
+V+C +W ++P C P+ + +F G +SCE G+ L
Sbjct: 1176 RRVKCQALNKWEPELPSCSR---VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDL 1232
Query: 405 KGSKRLQCGPTGEWDNEKPTCEAVRC-DAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEE 463
+G+ ++C P G+W PTCE C D + Q G V P+ + F C+E
Sbjct: 1233 RGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL---FPV-NLQLGAKVDFVCDE 1288
Query: 464 GFELHGSTQLECTSQGQ---WTEEVPSCQVVKCSSLAVPGKINMSCSGEPV----FGTVC 516
GF+L GS+ C G W VP C+ + C S P N +G+P+ FG
Sbjct: 1289 GFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPS--PPVIPNGRHTGKPLEVFPFGKAV 1346
Query: 517 KFAC---PEGWT---LNGSAARTCGA----TGHWS------GLLPTCEAP 550
+ C P+ T L G + C + G WS G+L C+AP
Sbjct: 1347 NYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAP 1396
Score = 120 bits (300), Expect = 5e-27
Identities = 106/442 (23%), Positives = 164/442 (37%), Gaps = 99/442 (22%)
Query: 196 PLGNFSYNSSCSISCD----RG--YLPSSMETMQCMS----SGEWSAPIPACNVV-ECDA 244
PL F + + + +CD RG + T++C S +G WS+P P C ++ C A
Sbjct: 1336 PLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 1395
Query: 245 VTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQ-SLQCTSSGNWDNEKPTCKAVT 303
+ ++ N FP T+ ++C E G S+ C + W + K CK +
Sbjct: 1396 PDHFLFAKLKTQTNASDFPIGTSLKYECRP--EYYGRPFSITCLDNLVWSSPKDVCKRKS 1453
Query: 304 CRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQG---QWTQQIP 360
C+ P NG V + S N++C G L G + EC G W+ + P
Sbjct: 1454 CKTPPDPVNGMVHV----ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPP 1509
Query: 361 VCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQG------FVLKGSKRLQC-- 412
+C+ C G + + + +F YGS + C G F L G + C
Sbjct: 1510 ICQRIPCGLPPTIANG--DFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTS 1567
Query: 413 --GPTGEWDNEKPTC-------------------------------------------EA 427
G W P C
Sbjct: 1568 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 1627
Query: 428 VRCDAVH-------------QPPKGLVRCAHSPIGE--FTYKSSCAFSCEEGFELHGSTQ 472
V+C A++ QPP ++ H+P + F+ +SCE G++L G+
Sbjct: 1628 VKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAAS 1687
Query: 473 LECTSQGQWTEEVPSCQVVKCSSL--AVP-GKINMSCSGEPVFGTVCKFACPEGWTLNGS 529
L CT QG W+ E P C V C +P G++ + + G F C EG+ L GS
Sbjct: 1688 LHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQ--LGAKVSFVCDEGFRLKGS 1745
Query: 530 AARTC---GATGHWSGLLPTCE 548
+ C G W+ +P CE
Sbjct: 1746 SVSHCVLVGMRSLWNNSVPVCE 1767
Score = 118 bits (296), Expect = 1e-26
Identities = 114/441 (25%), Positives = 166/441 (37%), Gaps = 58/441 (13%)
Query: 164 KCDPGFSGLKCEQIVNCTALESPEHG----SLVCSHP------------LGNFSYNSSCS 207
+C PGF +K + V C AL E S VC P NFS
Sbjct: 265 RCQPGFV-MKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVF 323
Query: 208 ISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPA-NGFVECFQNPGSFPWNT 266
SC+ GY +M+C G+WS P C V CD NG V P +
Sbjct: 324 YSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLF---PVNLQLGA 380
Query: 267 TCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAG 323
F C+EGF+L G+ + C +G W++ P C+ + C + NG R + P
Sbjct: 381 KVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNG--RHTGKPLE 438
Query: 324 EFTFKSSCNFTCEE------GFMLQGPAQVECTTQ----GQWTQQIPVCEAF-QCTALSN 372
F F + N+TC+ F L G + + CT+ G W+ P C C A +
Sbjct: 439 VFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDH 498
Query: 373 PERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDA 432
+ +AS F G+S ++ C + + + C W + K C+ C
Sbjct: 499 FLFAKLKTQTNAS-DFPIGTSLKYECRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKT 556
Query: 433 VHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ---WTEEVPSCQ 489
P G+V I + S +SC G L G + EC G W+ + P CQ
Sbjct: 557 PPDPVNGMVHV----ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
Query: 490 VVKCSSLAVPGKINMSCSGEPVF--GTVCKFACPEG------WTLNGSAARTCGAT---- 537
+ C + + F G+V + C G + L G + C +
Sbjct: 613 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQV 672
Query: 538 GHWSGLLPTCEAPTESNIPLV 558
G WSG P C P + P V
Sbjct: 673 GIWSGPAPQCIIPNKCTPPNV 693
Score = 118 bits (296), Expect = 1e-26
Identities = 114/441 (25%), Positives = 166/441 (37%), Gaps = 58/441 (13%)
Query: 164 KCDPGFSGLKCEQIVNCTALESPEHG----SLVCSHP------------LGNFSYNSSCS 207
+C PGF +K + V C AL E S VC P NFS
Sbjct: 715 RCQPGFV-MKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVF 773
Query: 208 ISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPA-NGFVECFQNPGSFPWNT 266
SC+ GY +M+C G+WS P C V CD NG V P +
Sbjct: 774 YSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLF---PVNLQLGA 830
Query: 267 TCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAG 323
F C+EGF+L G+ + C +G W++ P C+ + C + NG R + P
Sbjct: 831 KVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNG--RHTGKPLE 888
Query: 324 EFTFKSSCNFTCEE------GFMLQGPAQVECTTQ----GQWTQQIPVCEAF-QCTALSN 372
F F + N+TC+ F L G + + CT+ G W+ P C C A +
Sbjct: 889 VFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDH 948
Query: 373 PERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDA 432
+ +AS F G+S ++ C + + + C W + K C+ C
Sbjct: 949 FLFAKLKTQTNAS-DFPIGTSLKYECRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKT 1006
Query: 433 VHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ---WTEEVPSCQ 489
P G+V I + S +SC G L G + EC G W+ + P CQ
Sbjct: 1007 PPDPVNGMVHV----ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 1062
Query: 490 VVKCSSLAVPGKINMSCSGEPVF--GTVCKFACPEG------WTLNGSAARTCGAT---- 537
+ C + + F G+V + C G + L G + C +
Sbjct: 1063 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQV 1122
Query: 538 GHWSGLLPTCEAPTESNIPLV 558
G WSG P C P + P V
Sbjct: 1123 GIWSGPAPQCIIPNKCTPPNV 1143
Score = 117 bits (294), Expect = 2e-26
Identities = 114/441 (25%), Positives = 166/441 (37%), Gaps = 58/441 (13%)
Query: 164 KCDPGFSGLKCEQIVNCTALESPEHG----SLVCSHP------------LGNFSYNSSCS 207
+C PGF +K + V C AL E S VC P NFS
Sbjct: 1165 RCQPGFV-MKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVF 1223
Query: 208 ISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPA-NGFVECFQNPGSFPWNT 266
SC+ GY +M+C G+WS P C V CD NG V P +
Sbjct: 1224 YSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLF---PVNLQLGA 1280
Query: 267 TCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAG 323
F C+EGF+L G+ + C +G W++ P C+ + C + NG R + P
Sbjct: 1281 KVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNG--RHTGKPLE 1338
Query: 324 EFTFKSSCNFTCEE------GFMLQGPAQVECTTQ----GQWTQQIPVCEAF-QCTALSN 372
F F + N+TC+ F L G + + CT+ G W+ P C C A +
Sbjct: 1339 VFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDH 1398
Query: 373 PERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDA 432
+ +AS F G+S ++ C + + + C W + K C+ C
Sbjct: 1399 FLFAKLKTQTNAS-DFPIGTSLKYECRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKT 1456
Query: 433 VHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ---WTEEVPSCQ 489
P G+V I + S +SC G L G + EC G W+ + P CQ
Sbjct: 1457 PPDPVNGMVHV----ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1512
Query: 490 VVKCSSLAVPGKINMSCSGEPVF--GTVCKFACPEG------WTLNGSAARTCGAT---- 537
+ C + + F G+V + C G + L G + C +
Sbjct: 1513 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQV 1572
Query: 538 GHWSGLLPTCEAPTESNIPLV 558
G WSG P C P + P V
Sbjct: 1573 GIWSGPAPQCIIPNKCTPPNV 1593
Score = 117 bits (293), Expect = 3e-26
Identities = 98/386 (25%), Positives = 154/386 (39%), Gaps = 50/386 (12%)
Query: 196 PLGNFSYNSSCSISCD----RG--YLPSSMETMQCMS----SGEWSAPIPACNVV-ECDA 244
PL F + + + +CD RG + T++C S +G WS+P P C ++ C A
Sbjct: 436 PLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 495
Query: 245 VTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQ-SLQCTSSGNWDNEKPTCKAVT 303
+ ++ N FP T+ ++C E G S+ C + W + K CK +
Sbjct: 496 PDHFLFAKLKTQTNASDFPIGTSLKYECRP--EYYGRPFSITCLDNLVWSSPKDVCKRKS 553
Query: 304 CRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQG---QWTQQIP 360
C+ P NG V + S N++C G L G + EC G W+ + P
Sbjct: 554 CKTPPDPVNGMVHV----ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPP 609
Query: 361 VCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQG------FVLKGSKRLQC-- 412
+C+ C G + + + +F YGS + C G F L G + C
Sbjct: 610 ICQRIPCGLPPTIANG--DFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 667
Query: 413 --GPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGS 470
G W P C G++ + + F+ F C+ GF + G
Sbjct: 668 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGP 725
Query: 471 TQLECTSQGQWTEEVPSCQVVKC--------SSLAVPGKINMSCSGEPVFGTVCKFACPE 522
+++C + +W E+PSC V C + K N S G+ VF ++C
Sbjct: 726 RRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFS-PGQEVF-----YSCEP 778
Query: 523 GWTLNGSAARTCGATGHWSGLLPTCE 548
G+ L G+A+ C G WS PTCE
Sbjct: 779 GYDLRGAASMRCTPQGDWSPAAPTCE 804
Score = 117 bits (293), Expect = 3e-26
Identities = 98/386 (25%), Positives = 154/386 (39%), Gaps = 50/386 (12%)
Query: 196 PLGNFSYNSSCSISCD----RG--YLPSSMETMQCMS----SGEWSAPIPACNVV-ECDA 244
PL F + + + +CD RG + T++C S +G WS+P P C ++ C A
Sbjct: 886 PLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 945
Query: 245 VTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQ-SLQCTSSGNWDNEKPTCKAVT 303
+ ++ N FP T+ ++C E G S+ C + W + K CK +
Sbjct: 946 PDHFLFAKLKTQTNASDFPIGTSLKYECRP--EYYGRPFSITCLDNLVWSSPKDVCKRKS 1003
Query: 304 CRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQG---QWTQQIP 360
C+ P NG V + S N++C G L G + EC G W+ + P
Sbjct: 1004 CKTPPDPVNGMVHV----ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPP 1059
Query: 361 VCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQG------FVLKGSKRLQC-- 412
+C+ C G + + + +F YGS + C G F L G + C
Sbjct: 1060 ICQRIPCGLPPTIANG--DFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 1117
Query: 413 --GPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGS 470
G W P C G++ + + F+ F C+ GF + G
Sbjct: 1118 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGP 1175
Query: 471 TQLECTSQGQWTEEVPSCQVVKC--------SSLAVPGKINMSCSGEPVFGTVCKFACPE 522
+++C + +W E+PSC V C + K N S G+ VF ++C
Sbjct: 1176 RRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFS-PGQEVF-----YSCEP 1228
Query: 523 GWTLNGSAARTCGATGHWSGLLPTCE 548
G+ L G+A+ C G WS PTCE
Sbjct: 1229 GYDLRGAASMRCTPQGDWSPAAPTCE 1254
Score = 83.2 bits (204), Expect = 6e-16
Identities = 79/365 (21%), Positives = 122/365 (33%), Gaps = 104/365 (28%)
Query: 164 KCDPGF-----SGLKCE-------QIVNCTALESPE----HGSLVCSHPLGNFSYNSSCS 207
+C PGF ++C+ ++ +C+ + P HG SH NFS
Sbjct: 2068 RCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQ-DNFSPGQEVF 2126
Query: 208 ISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPA-NGFVECFQNPGSFPWNT 266
SC+ Y ++ C G+WS P C V CD +G V P +
Sbjct: 2127 YSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLL---PLNLQLGA 2183
Query: 267 TCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTC------------------- 304
+F C+EGF L G + C +G W++ P C+ + C
Sbjct: 2184 KVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDI 2243
Query: 305 ----------------------------RAVRQPQNGSVRCSHSPAGEFTFKSSC----- 331
R PQ V S +P E + ++C
Sbjct: 2244 PYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPK 2303
Query: 332 --------------------NFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALS 371
++ C+ G++L G + CT QG W+Q C+ C+
Sbjct: 2304 IQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPL 2363
Query: 372 NPERGYMNCLP---SASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAV 428
+MN + + YG CE G+ L+GS QC WD C +
Sbjct: 2364 -----FMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSR 2418
Query: 429 RCDAV 433
DA+
Sbjct: 2419 THDAL 2423
Score = 50.4 bits (119), Expect = 5e-06
Identities = 47/189 (24%), Positives = 69/189 (36%), Gaps = 26/189 (13%)
Query: 388 FRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSP 447
F G+ + C G+ + + C W K C C P G+V
Sbjct: 63 FPIGTYLNYECRPGYSGRPFSII-CLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHV---- 117
Query: 448 IGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ---WTEEVPSCQVVKCSSLAVPGKIN- 503
I + S +SC +G+ L GS+ C G W E P C + C +P I
Sbjct: 118 IKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCG---LPPTITN 174
Query: 504 ---MSCSGEPV-FGTVCKFACPEG------WTLNGSAARTCGAT----GHWSGLLPTCEA 549
+S + E +G+V + C G + L G + C + G WSG P C
Sbjct: 175 GDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCII 234
Query: 550 PTESNIPLV 558
P + P V
Sbjct: 235 PNKCTPPNV 243
>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
Length = 2039
Score = 155 bits (391), Expect = 1e-37
Identities = 122/446 (27%), Positives = 182/446 (40%), Gaps = 48/446 (10%)
Query: 147 SCSGHGECVETIN-----NYTCKCDPGFSGL------KCEQIVNCTALESPEHGSLVC-S 194
+C H + T N C DP +G+ +CE V ++PE +
Sbjct: 1349 TCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPT 1408
Query: 195 HPLGNFSY--NSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGF 252
P+ +F + +S + C GY M ++ C+ + WS+ C C P NG
Sbjct: 1409 IPINDFEFPVGTSLNYECRPGYF-GKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGM 1467
Query: 253 VECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQ 309
V + + +T + C EGF L+G+ S C SGN WD + P C+ ++C
Sbjct: 1468 VHINTDT---QFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPT 1524
Query: 310 PQNGSV----RCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQ----GQWTQQIPV 361
NG R S T++ E+ F L G + CT++ G W+ P
Sbjct: 1525 ISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPR 1584
Query: 362 C-EAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDN 420
C +CTA PE +P F F C+ GFV+ GS +QC G W
Sbjct: 1585 CISTNKCTA---PEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGP 1641
Query: 421 EKPTCEAVRCDAVHQPPKGLVRCAH--SPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQ 478
+ P C V QPP ++ H S F+ +SCE ++L G+ L CT Q
Sbjct: 1642 KLP-----HCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQ 1696
Query: 479 GQWTEEVPSCQVVKCSSL--AVP-GKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTC- 534
G W+ E P C V C +P G++ + + + G F C EG+ L G +A C
Sbjct: 1697 GDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQ--LGAKVSFVCDEGFRLKGRSASHCV 1754
Query: 535 --GATGHWSGLLPTCEAPTESNIPLV 558
G W+ +P CE N P +
Sbjct: 1755 LAGMKALWNSSVPVCEQIFCPNPPAI 1780
Score = 141 bits (355), Expect = 2e-33
Identities = 109/400 (27%), Positives = 165/400 (41%), Gaps = 44/400 (11%)
Query: 179 NCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE---WSAPIP 235
+C P +G + H + + S + SC G+ + +C+ SG WS P
Sbjct: 1003 SCKTPPDPVNGMV---HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPP 1059
Query: 236 ACNVVECDAVTNPANG-FVECFQNPGSFPWNTTCTFDCEEG------FELMGAQSLQCTS 288
C + C ANG F+ N +F + + T+ C G FEL+G S+ CTS
Sbjct: 1060 ICQRIPCGLPPTIANGDFIST--NRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTS 1117
Query: 289 S----GNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGP 344
+ G W P C +NG + + F+ F C+ GF+++GP
Sbjct: 1118 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGP 1175
Query: 345 AQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVL 404
+V+C +W ++P C PE + PS +F G +SCE G+ L
Sbjct: 1176 RRVKCQALNKWEPELPSCSR---VCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDL 1232
Query: 405 KGSKRLQCGPTGEWDNEKPTCEAVRC-DAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEE 463
+G+ L C P G+W E P C C D + Q P G V P+ + +F C+E
Sbjct: 1233 RGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVL---FPL-NLQLGAKVSFVCDE 1288
Query: 464 GFELHGSTQLECTSQGQ---WTEEVPSCQVVKCSS--LAVPGKINMSCSGEPVFGTVCKF 518
GF L GS+ C G W VP C+ + C + + G+ + SG+ +G +
Sbjct: 1289 GFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISY 1348
Query: 519 AC----PEGWTLN--GSAARTCGATGH----WSGLLPTCE 548
C G T N G + C + H WS P CE
Sbjct: 1349 TCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCE 1388
Score = 135 bits (339), Expect = 1e-31
Identities = 118/450 (26%), Positives = 180/450 (40%), Gaps = 72/450 (16%)
Query: 155 VETINNYTCKCDPGFSGLKCEQIV----------------NCTALESPEHGSLVCSHPLG 198
+ T NY C+ PG+SG I +C P +G + H +
Sbjct: 65 IGTYLNYECR--PGYSGRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMV---HVIK 119
Query: 199 NFSYNSSCSISCDRGYLPSSMETMQCMSSGE---WSAPIPACNVVECDAVTNPANG-FVE 254
+ S SC +GY + C+ SG+ W P C+ + C NG F+
Sbjct: 120 GIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIS 179
Query: 255 CFQNPGSFPWNTTCTFDCEEG------FELMGAQSLQCTSS----GNWDNEKPTCKAVTC 304
N +F + + T+ C G FEL+G S+ CTS+ G W P C
Sbjct: 180 T--NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 237
Query: 305 RAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEA 364
+NG + + F+ F C+ GF+++GP +V+C +W ++P C
Sbjct: 238 CTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSR 295
Query: 365 FQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPT 424
P+ + +F G +SCE G+ L+G+ ++C P G+W PT
Sbjct: 296 ---VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPT 352
Query: 425 CEAVRC-DAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ--- 480
CE C D + Q G V P+ + F C+EGF+L GS+ C G
Sbjct: 353 CEVKSCDDFMGQLLNGRVL---FPV-NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL 408
Query: 481 WTEEVPSCQVVKCSSLAVPGKINMSCSGEPV----FGTVCKFAC---PEGWT---LNGSA 530
W VP C+ + C S P N +G+P+ FG + C P+ T L G +
Sbjct: 409 WNSSVPVCEQIFCPS--PPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGES 466
Query: 531 ARTCGA----TGHWS------GLLPTCEAP 550
C + G WS G+L C+AP
Sbjct: 467 TIRCTSDPQGNGVWSSPAPRCGILGHCQAP 496
Score = 133 bits (335), Expect = 4e-31
Identities = 101/398 (25%), Positives = 156/398 (39%), Gaps = 31/398 (7%)
Query: 200 FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNP 259
F+ C G++ T+QC ++G W +P C+ V C +G +
Sbjct: 1609 FTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRV-CQPPPEILHG-EHTLSHQ 1666
Query: 260 GSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRA-VRQPQNGSVRCS 318
+F + CE ++L GA SL CT G+W E P C +C + Q +G V
Sbjct: 1667 DNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLP 1726
Query: 319 HSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQ---WTQQIPVCEAFQCTALSNPER 375
+ + +F C+EGF L+G + C G W +PVCE C
Sbjct: 1727 LN----LQLGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILN 1782
Query: 376 GYMNCLPSASGSFRYGSSCEFSCE------QGFVLKGSKRLQCGP----TGEWDNEKPTC 425
G P G YG ++C+ F L G ++C G W + P C
Sbjct: 1783 GRHTGTPF--GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRC 1840
Query: 426 EAVRCDAVHQPPKGLVRCAH---SPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWT 482
E A PPK ++ H + + + ++ C+ G+ L G + CT QG W+
Sbjct: 1841 ELSVPAACPHPPK--IQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWS 1898
Query: 483 EEVPSCQVVKCSSLAVPGKINMSCSGEPV--FGTVCKFACPEGWTLNGSAARTCGATGHW 540
+ C+ V CS I+ + V +G C +G+TL GS C A W
Sbjct: 1899 QLDHYCKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRW 1958
Query: 541 SGLLPTCEAPTESNIPLVAGLSAAGLSLLTLAPFLLWL 578
L C + T L+ G + + + L FL W+
Sbjct: 1959 DPPLAKCTSRTHD--ALIVGTLSGTIFFILLIIFLSWI 1994
Score = 132 bits (331), Expect = 1e-30
Identities = 110/410 (26%), Positives = 169/410 (41%), Gaps = 54/410 (13%)
Query: 179 NCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE---WSAPIP 235
+C P +G + H + + S + SC G+ + +C+ SG WS P
Sbjct: 553 SCKTPPDPVNGMV---HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPP 609
Query: 236 ACNVVECDAVTNPANG-FVECFQNPGSFPWNTTCTFDCEEG------FELMGAQSLQCTS 288
C + C ANG F+ N +F + + T+ C G FEL+G S+ CTS
Sbjct: 610 ICQRIPCGLPPTIANGDFIST--NRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 667
Query: 289 S----GNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGP 344
+ G W P C +NG + + F+ F C+ GF+++GP
Sbjct: 668 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGP 725
Query: 345 AQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVL 404
+V+C +W ++P C P+ + +F G +SCE G+ L
Sbjct: 726 RRVKCQALNKWEPELPSCSR---VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDL 782
Query: 405 KGSKRLQCGPTGEWDNEKPTCEAVRC-DAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEE 463
+G+ ++C P G+W PTCE C D + Q G V P+ + F C+E
Sbjct: 783 RGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL---FPV-NLQLGAKVDFVCDE 838
Query: 464 GFELHGSTQLECTSQGQ---WTEEVPSCQVVKCSSLAVPGKINMSCSGEPV----FGTVC 516
GF+L GS+ C G W VP C+ + C S P N +G+P+ FG
Sbjct: 839 GFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPS--PPVIPNGRHTGKPLEVFPFGKAV 896
Query: 517 KFAC---PEGWT---LNGSAARTCGA----TGHWS------GLLPTCEAP 550
+ C P+ T L G + C + G WS G+L C+AP
Sbjct: 897 NYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAP 946
Score = 120 bits (300), Expect = 5e-27
Identities = 106/442 (23%), Positives = 164/442 (37%), Gaps = 99/442 (22%)
Query: 196 PLGNFSYNSSCSISCD----RG--YLPSSMETMQCMS----SGEWSAPIPACNVV-ECDA 244
PL F + + + +CD RG + T++C S +G WS+P P C ++ C A
Sbjct: 886 PLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 945
Query: 245 VTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQ-SLQCTSSGNWDNEKPTCKAVT 303
+ ++ N FP T+ ++C E G S+ C + W + K CK +
Sbjct: 946 PDHFLFAKLKTQTNASDFPIGTSLKYECRP--EYYGRPFSITCLDNLVWSSPKDVCKRKS 1003
Query: 304 CRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQG---QWTQQIP 360
C+ P NG V + S N++C G L G + EC G W+ + P
Sbjct: 1004 CKTPPDPVNGMVHV----ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPP 1059
Query: 361 VCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQG------FVLKGSKRLQC-- 412
+C+ C G + + + +F YGS + C G F L G + C
Sbjct: 1060 ICQRIPCGLPPTIANG--DFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTS 1117
Query: 413 --GPTGEWDNEKPTC-------------------------------------------EA 427
G W P C
Sbjct: 1118 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 1177
Query: 428 VRCDAVH-------------QPPKGLVRCAHSPIGE--FTYKSSCAFSCEEGFELHGSTQ 472
V+C A++ QPP ++ H+P + F+ +SCE G++L G+
Sbjct: 1178 VKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAAS 1237
Query: 473 LECTSQGQWTEEVPSCQVVKCSSL--AVP-GKINMSCSGEPVFGTVCKFACPEGWTLNGS 529
L CT QG W+ E P C V C +P G++ + + G F C EG+ L GS
Sbjct: 1238 LHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQ--LGAKVSFVCDEGFRLKGS 1295
Query: 530 AARTC---GATGHWSGLLPTCE 548
+ C G W+ +P CE
Sbjct: 1296 SVSHCVLVGMRSLWNNSVPVCE 1317
Score = 118 bits (296), Expect = 1e-26
Identities = 114/441 (25%), Positives = 166/441 (37%), Gaps = 58/441 (13%)
Query: 164 KCDPGFSGLKCEQIVNCTALESPEHG----SLVCSHP------------LGNFSYNSSCS 207
+C PGF +K + V C AL E S VC P NFS
Sbjct: 265 RCQPGFV-MKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVF 323
Query: 208 ISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPA-NGFVECFQNPGSFPWNT 266
SC+ GY +M+C G+WS P C V CD NG V P +
Sbjct: 324 YSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLF---PVNLQLGA 380
Query: 267 TCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAG 323
F C+EGF+L G+ + C +G W++ P C+ + C + NG R + P
Sbjct: 381 KVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNG--RHTGKPLE 438
Query: 324 EFTFKSSCNFTCEE------GFMLQGPAQVECTTQ----GQWTQQIPVCEAF-QCTALSN 372
F F + N+TC+ F L G + + CT+ G W+ P C C A +
Sbjct: 439 VFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDH 498
Query: 373 PERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDA 432
+ +AS F G+S ++ C + + + C W + K C+ C
Sbjct: 499 FLFAKLKTQTNAS-DFPIGTSLKYECRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKT 556
Query: 433 VHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ---WTEEVPSCQ 489
P G+V I + S +SC G L G + EC G W+ + P CQ
Sbjct: 557 PPDPVNGMVHV----ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612
Query: 490 VVKCSSLAVPGKINMSCSGEPVF--GTVCKFACPEG------WTLNGSAARTCGAT---- 537
+ C + + F G+V + C G + L G + C +
Sbjct: 613 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQV 672
Query: 538 GHWSGLLPTCEAPTESNIPLV 558
G WSG P C P + P V
Sbjct: 673 GIWSGPAPQCIIPNKCTPPNV 693
Score = 117 bits (294), Expect = 2e-26
Identities = 114/441 (25%), Positives = 166/441 (37%), Gaps = 58/441 (13%)
Query: 164 KCDPGFSGLKCEQIVNCTALESPEHG----SLVCSHP------------LGNFSYNSSCS 207
+C PGF +K + V C AL E S VC P NFS
Sbjct: 715 RCQPGFV-MKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVF 773
Query: 208 ISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPA-NGFVECFQNPGSFPWNT 266
SC+ GY +M+C G+WS P C V CD NG V P +
Sbjct: 774 YSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLF---PVNLQLGA 830
Query: 267 TCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAG 323
F C+EGF+L G+ + C +G W++ P C+ + C + NG R + P
Sbjct: 831 KVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNG--RHTGKPLE 888
Query: 324 EFTFKSSCNFTCEE------GFMLQGPAQVECTTQ----GQWTQQIPVCEAF-QCTALSN 372
F F + N+TC+ F L G + + CT+ G W+ P C C A +
Sbjct: 889 VFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDH 948
Query: 373 PERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDA 432
+ +AS F G+S ++ C + + + C W + K C+ C
Sbjct: 949 FLFAKLKTQTNAS-DFPIGTSLKYECRPEYYGRPFS-ITCLDNLVWSSPKDVCKRKSCKT 1006
Query: 433 VHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ---WTEEVPSCQ 489
P G+V I + S +SC G L G + EC G W+ + P CQ
Sbjct: 1007 PPDPVNGMVHV----ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1062
Query: 490 VVKCSSLAVPGKINMSCSGEPVF--GTVCKFACPEG------WTLNGSAARTCGAT---- 537
+ C + + F G+V + C G + L G + C +
Sbjct: 1063 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQV 1122
Query: 538 GHWSGLLPTCEAPTESNIPLV 558
G WSG P C P + P V
Sbjct: 1123 GIWSGPAPQCIIPNKCTPPNV 1143
Score = 117 bits (293), Expect = 3e-26
Identities = 98/386 (25%), Positives = 154/386 (39%), Gaps = 50/386 (12%)
Query: 196 PLGNFSYNSSCSISCD----RG--YLPSSMETMQCMS----SGEWSAPIPACNVV-ECDA 244
PL F + + + +CD RG + T++C S +G WS+P P C ++ C A
Sbjct: 436 PLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQA 495
Query: 245 VTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQ-SLQCTSSGNWDNEKPTCKAVT 303
+ ++ N FP T+ ++C E G S+ C + W + K CK +
Sbjct: 496 PDHFLFAKLKTQTNASDFPIGTSLKYECRP--EYYGRPFSITCLDNLVWSSPKDVCKRKS 553
Query: 304 CRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQG---QWTQQIP 360
C+ P NG V + S N++C G L G + EC G W+ + P
Sbjct: 554 CKTPPDPVNGMVHV----ITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPP 609
Query: 361 VCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQG------FVLKGSKRLQC-- 412
+C+ C G + + + +F YGS + C G F L G + C
Sbjct: 610 ICQRIPCGLPPTIANG--DFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 667
Query: 413 --GPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGS 470
G W P C G++ + + F+ F C+ GF + G
Sbjct: 668 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFVMKGP 725
Query: 471 TQLECTSQGQWTEEVPSCQVVKC--------SSLAVPGKINMSCSGEPVFGTVCKFACPE 522
+++C + +W E+PSC V C + K N S G+ VF ++C
Sbjct: 726 RRVKCQALNKWEPELPSCSRV-CQPPPDVLHAERTQRDKDNFS-PGQEVF-----YSCEP 778
Query: 523 GWTLNGSAARTCGATGHWSGLLPTCE 548
G+ L G+A+ C G WS PTCE
Sbjct: 779 GYDLRGAASMRCTPQGDWSPAAPTCE 804
Score = 83.2 bits (204), Expect = 6e-16
Identities = 79/365 (21%), Positives = 122/365 (33%), Gaps = 104/365 (28%)
Query: 164 KCDPGF-----SGLKCE-------QIVNCTALESPE----HGSLVCSHPLGNFSYNSSCS 207
+C PGF ++C+ ++ +C+ + P HG SH NFS
Sbjct: 1618 RCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQ-DNFSPGQEVF 1676
Query: 208 ISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPA-NGFVECFQNPGSFPWNT 266
SC+ Y ++ C G+WS P C V CD +G V P +
Sbjct: 1677 YSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLL---PLNLQLGA 1733
Query: 267 TCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTC------------------- 304
+F C+EGF L G + C +G W++ P C+ + C
Sbjct: 1734 KVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDI 1793
Query: 305 ----------------------------RAVRQPQNGSVRCSHSPAGEFTFKSSC----- 331
R PQ V S +P E + ++C
Sbjct: 1794 PYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPK 1853
Query: 332 --------------------NFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALS 371
++ C+ G++L G + CT QG W+Q C+ C+
Sbjct: 1854 IQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPL 1913
Query: 372 NPERGYMNCLP---SASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAV 428
+MN + + YG CE G+ L+GS QC WD C +
Sbjct: 1914 -----FMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSR 1968
Query: 429 RCDAV 433
DA+
Sbjct: 1969 THDAL 1973
Score = 50.4 bits (119), Expect = 5e-06
Identities = 47/189 (24%), Positives = 69/189 (36%), Gaps = 26/189 (13%)
Query: 388 FRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSP 447
F G+ + C G+ + + C W K C C P G+V
Sbjct: 63 FPIGTYLNYECRPGYSGRPFSII-CLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHV---- 117
Query: 448 IGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ---WTEEVPSCQVVKCSSLAVPGKIN- 503
I + S +SC +G+ L GS+ C G W E P C + C +P I
Sbjct: 118 IKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCG---LPPTITN 174
Query: 504 ---MSCSGEPV-FGTVCKFACPEG------WTLNGSAARTCGAT----GHWSGLLPTCEA 549
+S + E +G+V + C G + L G + C + G WSG P C
Sbjct: 175 GDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCII 234
Query: 550 PTESNIPLV 558
P + P V
Sbjct: 235 PNKCTPPNV 243
>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
sapiens]
Length = 569
Score = 145 bits (366), Expect = 1e-34
Identities = 116/441 (26%), Positives = 173/441 (39%), Gaps = 53/441 (12%)
Query: 155 VETINNYTCKCDPGFSGL-----------------KCEQIVNCTALESPEHGSLVCSHPL 197
+ T NY C+ PG+SG KC++ +C P +G +H +
Sbjct: 57 IGTYLNYECR--PGYSGRPFSIICLKNSVWTSAKDKCKR-KSCRNPPDPVNGM---AHVI 110
Query: 198 GNFSYNSSCSISCDRGYLPSSMETMQCMSSGE---WSAPIPACNVVECDAVTNPANGFVE 254
+ + S SC +GY + C+ SG W P C+ + C ANG
Sbjct: 111 KDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFT 170
Query: 255 CFQNPGSFPWNTTCTFDCEEG------FELMGAQSLQCTSS----GNWDNEKPTCKAVTC 304
F + + T+ C G FEL+G S+ CTS G W P C
Sbjct: 171 SISRE-YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNK 229
Query: 305 RAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEA 364
+NG + + F+ F C+ GF ++GP+ V+C +W ++P C
Sbjct: 230 CTPPNVENGILVSDNRSL--FSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSR 287
Query: 365 FQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPT 424
P+ + +F G +SCE G+ L+GS L C P G+W P
Sbjct: 288 ---VCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPR 344
Query: 425 CEAVRC-DAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ--- 480
CE C D + Q P G V P+ + F C+EGF+L GS+ C G
Sbjct: 345 CEVKSCDDFLGQLPNGHVL---FPL-NLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESL 400
Query: 481 WTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTC---GAT 537
W VP C+ C + VP + + G+ ++C G L G ++ C G T
Sbjct: 401 WNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNT 460
Query: 538 GHWSGLLPTCEAPTESNIPLV 558
HWS P C+ N P +
Sbjct: 461 AHWSMKPPICQQIFCPNPPAI 481
Score = 139 bits (349), Expect = 1e-32
Identities = 98/373 (26%), Positives = 150/373 (40%), Gaps = 42/373 (11%)
Query: 200 FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNP 259
F + + C GY + C+ + W++ C C +P NG ++
Sbjct: 55 FPIGTYLNYECRPGYSGRPFSII-CLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKD- 112
Query: 260 GSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVR 316
+ + + C +G+ L+G+ S C SGN WDN+ P C + C NG
Sbjct: 113 --IQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDF- 169
Query: 317 CSHSPAGEFTFKSSCNFTCEEG------FMLQGPAQVECTTQ----GQWTQQIPVCEAFQ 366
+ F + S + C G F L G + CT++ G W+ P C
Sbjct: 170 -TSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPN 228
Query: 367 CTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCE 426
N E G + + F EF C+ GF +KG ++C +W+ E P+C
Sbjct: 229 KCTPPNVENGIL--VSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCS 286
Query: 427 AVRCDAVHQPPKGLVRCAHSPIGE--FTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEE 484
V C QPP ++ + + F+ +SCE G++L GST L CT QG W+
Sbjct: 287 RV-C----QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPA 341
Query: 485 VPSCQVVKCSSLAVPGKINMSCSGEPVF------GTVCKFACPEGWTLNGSAARTC---G 535
P C+V C + +G +F G F C EG+ L GS+A C G
Sbjct: 342 APRCEVKSCDDF-----LGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAG 396
Query: 536 ATGHWSGLLPTCE 548
W+ +P CE
Sbjct: 397 MESLWNSSVPVCE 409
Score = 129 bits (323), Expect = 1e-29
Identities = 103/387 (26%), Positives = 148/387 (38%), Gaps = 55/387 (14%)
Query: 200 FSYNSSCSISCDRGYL----------PSSMETMQCMSSGEWSAPIPACNVVECDAVTNPA 249
F Y S + C+ G PS T + G WS P P C + N
Sbjct: 177 FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVE 236
Query: 250 NGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQ 309
NG + N F N F C+ GF + G ++C + W+ E P+C V Q
Sbjct: 237 NGILVS-DNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVC-----Q 290
Query: 310 PQNGSVRCSHSPAGEFTFKSSCN--FTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQC 367
P + + + F ++CE G+ L+G + CT QG W+ P CE C
Sbjct: 291 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSC 350
Query: 368 TALSNPERGYMNCLPSASGSF----RYGSSCEFSCEQGFVLKGSKRLQC---GPTGEWDN 420
++ LP+ F + G+ +F C++GF LKGS C G W++
Sbjct: 351 D-------DFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS 403
Query: 421 EKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQG- 479
P CE C+ P G+V I + S +SC G L G + EC G
Sbjct: 404 SVPVCERKSCETPPVPVNGMVHV----ITDIHVGSRINYSCTTGHRLIGHSSAECILSGN 459
Query: 480 --QWTEEVPSCQVVKCSSLAVPGKINMSCSGEPV----FGTVCKFAC----PEGWTLNGS 529
W+ + P CQ + C + P +N +G P+ +G + C G T N
Sbjct: 460 TAHWSMKPPICQQIFCPN--PPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLI 517
Query: 530 AARTCGAT------GHWSGLLPTCEAP 550
T T G WS P CE P
Sbjct: 518 GESTIRRTSEPHGNGVWSSPAPRCELP 544
Score = 92.0 bits (227), Expect = 1e-18
Identities = 79/296 (26%), Positives = 108/296 (36%), Gaps = 43/296 (14%)
Query: 164 KCDPGFSGLKCEQIVNCTALESPEHG----SLVCSHP------------LGNFSYNSSCS 207
+C PGF G+K V C AL E S VC P NFS
Sbjct: 257 RCQPGF-GMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVF 315
Query: 208 ISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNP-ANGFVECFQNPGSFPWNT 266
SC+ GY + C G+WS P C V CD NG V P +
Sbjct: 316 YSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHV---LFPLNLQLGA 372
Query: 267 TCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAG 323
F C+EGF+L G+ + C +G W++ P C+ +C P NG V
Sbjct: 373 KVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHV----IT 428
Query: 324 EFTFKSSCNFTCEEGFMLQGPAQVECTTQG---QWTQQIPVCEAFQCTALSNPERGYMNC 380
+ S N++C G L G + EC G W+ + P+C+ C G
Sbjct: 429 DIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTG 488
Query: 381 LPSASGSFRYGSSCEFSCE------QGFVLKGSKRL----QCGPTGEWDNEKPTCE 426
P G YG ++C+ F L G + + G W + P CE
Sbjct: 489 TP--LGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCE 542
>gi|4502503 complement component 4 binding protein, alpha chain
precursor [Homo sapiens]
Length = 597
Score = 115 bits (287), Expect = 2e-25
Identities = 100/428 (23%), Positives = 155/428 (36%), Gaps = 55/428 (12%)
Query: 157 TINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLV----CSHP----------LGNFSY 202
T YTC PG+ Q + C + + + C HP + S+
Sbjct: 75 TTLKYTCL--PGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGELRNGQVEIKTDLSF 132
Query: 203 NSSCSISCDRGYLPSSMETMQCMSSGE---WSAPIPACNVVECDAVTNPANGFVECFQNP 259
S SC G+ T +C WS P+P C +V+C + NG +N
Sbjct: 133 GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEEN- 191
Query: 260 GSFPWNTTCTFDCEEGFELMGAQSLQCT----SSGNWDNEKPTCKAVTCRAVRQPQNGSV 315
+ + + T+ C+ F L+G S+ CT + G W PTC+ +TCR +G +
Sbjct: 192 -FYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRK-PDVSHGEM 249
Query: 316 RCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPER 375
P + +K + F C++GF+L+G + + C +W P CE C L +
Sbjct: 250 VSGFGPI--YNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPH 307
Query: 376 GYMNCLPSASGSFRY--GSSCEFSCEQGF--VLKGSKRLQCGPTGEWDNEKPTCEAVRCD 431
P + Y G+ + C G+ + C W CEA+ C
Sbjct: 308 ASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRW-TPYQGCEALCCP 366
Query: 432 ---------AVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWT 482
H+ + C + Y +FSC E C G W+
Sbjct: 367 EPKLNNGEITQHRKSRPANHCV------YFYGDEISFSCHETSRFSAI----CQGDGTWS 416
Query: 483 EEVPSC-QVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWS 541
PSC + G S S F + C +G+ L G A +C + HWS
Sbjct: 417 PRTPSCGDICNFPPKIAHGHYKQS-SSYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWS 474
Query: 542 GLLPTCEA 549
P C+A
Sbjct: 475 APAPQCKA 482
Score = 108 bits (269), Expect = 2e-23
Identities = 80/281 (28%), Positives = 113/281 (40%), Gaps = 33/281 (11%)
Query: 262 FPWNTTCTFDCEEGF-ELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHS 320
F TT + C G+ Q+L C S G W C CR + +NG V
Sbjct: 71 FKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVEIKT- 128
Query: 321 PAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQ---WTQQIPVCEAFQCTALSNPERGY 377
+ +F S F+C EGF L G C Q + W+ +P CE +C P
Sbjct: 129 ---DLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKC----KPPPDI 181
Query: 378 MNCLPSASGSF-RYGSSCEFSCEQGFVLKGSKRLQCGPTGE----WDNEKPTCEAVRC-- 430
N S +F YG S +SC+ F L G + C E W PTCE + C
Sbjct: 182 RNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRK 241
Query: 431 -DAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQ 489
D H G + PI + YK + F C++GF L GS+ + C + +W P+C+
Sbjct: 242 PDVSH----GEMVSGFGPI--YNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACE 295
Query: 490 VVKCSSLAVPGKINMSCSGEP------VFGTVCKFACPEGW 524
C +L + P V GTV ++ C G+
Sbjct: 296 PNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGY 336
Score = 92.4 bits (228), Expect = 1e-18
Identities = 86/370 (23%), Positives = 137/370 (37%), Gaps = 38/370 (10%)
Query: 200 FSYNSSCSISCDRGYLPSSMETMQCMSSGE----WSAPIPACNVVECDAVTNPANGFVEC 255
++Y S + SCD + ++ C E W P C + C P E
Sbjct: 193 YAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITC---RKPDVSHGEM 249
Query: 256 FQNPGS-FPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGS 314
G + + T F C++GF L G+ + C + W+ P C+ +C + + S
Sbjct: 250 VSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHAS 309
Query: 315 VRCSHSPAGE--FTFKSSCNFTCEEGFM--LQGPAQVECTTQGQWTQQIPVCEAFQCTA- 369
P E + + + C G+ P V C +WT CEA C
Sbjct: 310 WETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTPY-QGCEALCCPEP 368
Query: 370 -LSNPE-RGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEA 427
L+N E + P+ + YG FSC + C G W P+C
Sbjct: 369 KLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFSAI----CQGDGTWSPRTPSCG- 423
Query: 428 VRCDAVHQPPKGLVRCAHSPIGEFT----YKSSCAFSCEEGFELHGSTQLECTSQGQWTE 483
D + PPK AH + + +K + C++G+ L G +L C S W+
Sbjct: 424 ---DICNFPPK----IAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWSA 475
Query: 484 EVPSCQVVKCSSLAVPGKINMSCSG--EPVFGTVCKFACPEGWTLNGSAARTCGATGHWS 541
P C+ + V G++++ EP T+ C G+ + G + TC W
Sbjct: 476 PAPQCKALCRKPELVNGRLSVDKDQYVEPENVTI---QCDSGYGVVGPQSITCSGNRTWY 532
Query: 542 GLLPTCEAPT 551
+P CE T
Sbjct: 533 PEVPKCEWET 542
Score = 91.3 bits (225), Expect = 2e-18
Identities = 67/243 (27%), Positives = 100/243 (41%), Gaps = 21/243 (8%)
Query: 325 FTFKSSCNFTCEEGFMLQGPAQ-VECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPS 383
F ++ +TC G++ Q + C + G+W C +C G +
Sbjct: 71 FKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVEIKTD 129
Query: 384 ASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGE---WDNEKPTCEAVRCDAVHQPPKGL 440
S +GS EFSC +GF L GS +C W + P CE V+C +PP +
Sbjct: 130 LS----FGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKC----KPPPDI 181
Query: 441 VRCAHSPIGEF-TYKSSCAFSCEEGFELHGSTQLECTSQ----GQWTEEVPSCQVVKCSS 495
HS F Y S +SC+ F L G + CT + G W P+C+ + C
Sbjct: 182 RNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRK 241
Query: 496 LAVPGKINMSCSGEPVFG--TVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTES 553
V +S G P++ F C +G+ L GS+ C A W+ P CE +
Sbjct: 242 PDVSHGEMVSGFG-PIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCI 300
Query: 554 NIP 556
N+P
Sbjct: 301 NLP 303
Score = 67.8 bits (164), Expect = 3e-11
Identities = 67/335 (20%), Positives = 128/335 (38%), Gaps = 30/335 (8%)
Query: 188 HGSLVCSH-PLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVT 246
HG +V P+ ++Y + C +G++ + C + +W+ PAC C +
Sbjct: 246 HGEMVSGFGPI--YNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLP 303
Query: 247 NPANGFVECFQNPGS---FPWNTTCTFDCEEGFELMGAQ--SLQCTSSGNWDNEKPTCKA 301
+ + E + P + T + C G++ + ++ C + W C+A
Sbjct: 304 DIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRW-TPYQGCEA 362
Query: 302 VTCRAVRQPQNGSV--RCSHSPAGE--FTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQ 357
+ C + NG + PA + + +F+C E C G W+
Sbjct: 363 LCCPEPKL-NNGEITQHRKSRPANHCVYFYGDEISFSCHE----TSRFSAICQGDGTWSP 417
Query: 358 QIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGE 417
+ P C C P+ + + S+S SF + + C++G++L G +L C
Sbjct: 418 RTPSCGDI-CN--FPPKIAHGHYKQSSSYSF-FKEEIIYECDKGYILVGQAKLSCS-YSH 472
Query: 418 WDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTS 477
W P C+A+ C + P+ + ++ + C+ G+ + G + C+
Sbjct: 473 WSAPAPQCKAL-C----RKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQSITCSG 527
Query: 478 QGQWTEEVPSC--QVVKCSSLAVPGKINMSCSGEP 510
W EVP C + + + GK M C P
Sbjct: 528 NRTWYPEVPKCEWETPEGCEQVLTGKRLMQCLPNP 562
>gi|153266841 apolipoprotein H precursor [Homo sapiens]
Length = 345
Score = 105 bits (262), Expect = 1e-22
Identities = 71/262 (27%), Positives = 103/262 (39%), Gaps = 11/262 (4%)
Query: 169 FSGLKCEQIVNCTALESPEHGSLVCSHPLGNF-SYNSSCSISCDRGYLP-SSMETMQCMS 226
FS C + P+ PL F + SC GY+ M C
Sbjct: 9 FSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPL 68
Query: 227 SGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQC 286
+G W C C NG V +F + T +F C GF L GA S +C
Sbjct: 69 TGLWPINTLKCTPRVCPFAGILENGAVRYT----TFEYPNTISFSCNTGFYLNGADSAKC 124
Query: 287 TSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFT-FKSSCNFTCEEGFMLQGPA 345
T G W E P C + C P ++R AG + ++ + F C + G
Sbjct: 125 TEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGND 184
Query: 346 QVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLK 405
+ CTT G WT ++P C +C S P+ G++N A + Y F C G+ L
Sbjct: 185 TITCTTHGNWT-KLPECREVKCPFPSRPDNGFVNY--PAKPTLYYKDKATFGCHDGYSLD 241
Query: 406 GSKRLQCGPTGEWDNEKPTCEA 427
G + ++C G W + P+C+A
Sbjct: 242 GPEEIECTKLGNW-SAMPSCKA 262
Score = 95.5 bits (236), Expect = 1e-19
Identities = 59/221 (26%), Positives = 98/221 (44%), Gaps = 11/221 (4%)
Query: 333 FTCEEGFMLQGPAQ-VECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYG 391
++C+ G++ +G + C G W P+ +CT P G + +F Y
Sbjct: 49 YSCKPGYVSRGGMRKFICPLTGLW----PI-NTLKCTPRVCPFAGILENGAVRYTTFEYP 103
Query: 392 SSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEF 451
++ FSC GF L G+ +C G+W E P C + C P +R G
Sbjct: 104 NTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNN 163
Query: 452 T-YKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVP--GKINMSCSG 508
+ Y+ + F C + G+ + CT+ G WT ++P C+ VKC + P G +N
Sbjct: 164 SLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECREVKCPFPSRPDNGFVNYPAKP 222
Query: 509 EPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEA 549
+ F C +G++L+G C G+WS +P+C+A
Sbjct: 223 TLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSA-MPSCKA 262
Score = 72.4 bits (176), Expect = 1e-12
Identities = 45/163 (27%), Positives = 69/163 (42%), Gaps = 12/163 (7%)
Query: 391 GSSCEFSCEQGFVLKGSKR-LQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIG 449
G +SC+ G+V +G R C TG W C C G VR
Sbjct: 44 GEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYT----- 98
Query: 450 EFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINM----- 504
F Y ++ +FSC GF L+G+ +CT +G+W+ E+P C + C ++P +
Sbjct: 99 TFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKP 158
Query: 505 SCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTC 547
S ++ F C + G+ TC G+W+ LP C
Sbjct: 159 SAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPEC 200
>gi|5454086 sushi-repeat-containing protein, X-linked [Homo sapiens]
Length = 464
Score = 99.0 bits (245), Expect = 1e-20
Identities = 70/266 (26%), Positives = 116/266 (43%), Gaps = 32/266 (12%)
Query: 187 EHGSLVCSHPLGNF---SYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECD 243
++G + C P G + + + C I C +GY + C S+ WS + C C
Sbjct: 63 KYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-ICKQKRCP 121
Query: 244 AVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTC---- 299
+ PANG +C G++ +N+ C + C G+ L G +++ C + W +C
Sbjct: 122 TLAMPANGGFKCVD--GAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDME 178
Query: 300 -KAVTCRAVRQ----PQNGSVRCS-HSPAGEFTFKSSCNFTCEEGF-----MLQGPAQVE 348
+ C +V++ P +VR S +P G T +G +G +++
Sbjct: 179 PPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQ 238
Query: 349 CTT------QGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGF 402
T +G ++ V +C L+ PE GYM C +S YG++CEFSC G+
Sbjct: 239 YTVYDRAENKGTCKFRVKV-RVKRCGKLNAPENGYMKC---SSDGDNYGATCEFSCIGGY 294
Query: 403 VLKGSKRLQCGPTGEWDNEKPTCEAV 428
L+GS C W +PTC A+
Sbjct: 295 ELQGSPARVCQSNLAWSGTEPTCAAM 320
Score = 97.4 bits (241), Expect = 3e-20
Identities = 71/261 (27%), Positives = 113/261 (43%), Gaps = 30/261 (11%)
Query: 313 GSVRCSHSPAGEF--TFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTAL 370
G V C G + + C+ C++G+ L G + + C + +W+ ++ +C+ +C L
Sbjct: 65 GDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-ICKQKRCPTL 123
Query: 371 SNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTC----- 425
+ P G C+ A + S CE+ C G+ LKG + + C W +C
Sbjct: 124 AMPANGGFKCVDGAY----FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEP 179
Query: 426 EAVRCDAVHQ----PPKGLVRCA-HSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ 480
++C +V + P K VR + +P G T +G GS E + Q
Sbjct: 180 PRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLP-PGSNFPEGDHKIQ 238
Query: 481 WT-----EEVPSCQ------VVKCSSLAVPGKINMSCSGE-PVFGTVCKFACPEGWTLNG 528
+T E +C+ V +C L P M CS + +G C+F+C G+ L G
Sbjct: 239 YTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQG 298
Query: 529 SAARTCGATGHWSGLLPTCEA 549
S AR C + WSG PTC A
Sbjct: 299 SPARVCQSNLAWSGTEPTCAA 319
Score = 41.6 bits (96), Expect = 0.002
Identities = 22/81 (27%), Positives = 34/81 (41%), Gaps = 2/81 (2%)
Query: 176 QIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIP 235
++ C L +PE+G + CS N Y ++C SC GY C S+ WS P
Sbjct: 258 RVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQGSPARVCQSNLAWSGTEP 315
Query: 236 ACNVVECDAVTNPANGFVECF 256
C + + A ++ F
Sbjct: 316 TCAAMNVNVGVRTAAALLDQF 336
>gi|110611237 coagulation factor XIII B subunit precursor [Homo
sapiens]
Length = 661
Score = 97.8 bits (242), Expect = 3e-20
Identities = 105/381 (27%), Positives = 156/381 (40%), Gaps = 63/381 (16%)
Query: 201 SYNSSCSISCDRGYLPSS---METMQCMSSGEWSAPIPACNVVECDAVTNP--ANGFVEC 255
S + S C GY S E C + G WS P P C +C T P +NG++
Sbjct: 50 SIDKKLSFFCLAGYTTESGRQEEQTTCTTEG-WS-PEPRC-FKKC---TKPDLSNGYISD 103
Query: 256 FQNPGSFPWNTTCTFDCEEGFELMGAQS---LQCTSSGNWDNEKPTCKAV--TCRAVRQP 310
+ N + C G++ G + +QC S G W ++ PTC+ TC A +
Sbjct: 104 VKLLYKIQENMR--YGCASGYKTTGGKDEEVVQCLSDG-WSSQ-PTCRKEHETCLAP-EL 158
Query: 311 QNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQG---PAQVECTTQGQWTQQIPVCEAFQC 367
NG+ + F K + C G+ G +VEC T G W+ P C +C
Sbjct: 159 YNGNYSTTQKT---FKVKDKVQYECATGYYTAGGKKTEEVECLTYG-WSLT-PKCTKLKC 213
Query: 368 TALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEA 427
++L E GY + + ++ G +F C + + L GS +QC G W E P CE
Sbjct: 214 SSLRLIENGYFHPVKQ---TYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEG 269
Query: 428 VRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPS 487
R + PP + + + + CE FE+HGS ++ C G+WTE P
Sbjct: 270 RR-NRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWTEP-PK 326
Query: 488 CQVVKCSSLAVPGKINMSCSGEPVF---------------GTVCKFACPEGWTLNGSAAR 532
C + G+ ++C EP F G +AC G+ L+GS
Sbjct: 327 C---------IEGQEKVACE-EPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEI 376
Query: 533 TCGATGHWSGLLPTCEAPTES 553
TC G W+ L P C E+
Sbjct: 377 TCN-RGKWT-LPPECVENNEN 395
Score = 70.1 bits (170), Expect = 6e-12
Identities = 85/401 (21%), Positives = 146/401 (36%), Gaps = 46/401 (11%)
Query: 98 APGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVET 157
A G KDE+ V+ W+ + +K+ C N + S + +
Sbjct: 119 ASGYKTTGGKDEEVVQCLSDG------WSSQPTCRKEHETCLAPELYNGNYSTTQKTFKV 172
Query: 158 INNYTCKCDPGF---SGLKCEQI---------------VNCTALESPEHGSLVCSHPLGN 199
+ +C G+ G K E++ + C++L E+G HP+
Sbjct: 173 KDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYF---HPVKQ 229
Query: 200 -FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVE--CDAVTNPANGFVECF 256
+ C Y S + +QC + G W P C C P N ++
Sbjct: 230 TYEEGDVVQFFCHENYYLSGSDLIQCYNFG-WYPESPVCEGRRNRCPPPPLPINSKIQTH 288
Query: 257 QNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTC----KAVTCRAVRQPQN 312
++ +CE FE+ G+ ++C G W E P C + V C +N
Sbjct: 289 ST--TYRHGEIVHIECELNFEIHGSAEIRC-EDGKW-TEPPKCIEGQEKVACEEPPFIEN 344
Query: 313 GSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSN 372
G+ HS + + C+ G++L G ++ C +G+WT P C
Sbjct: 345 GAANL-HSKI--YYNGDKVTYACKSGYLLHGSNEITCN-RGKWTLP-PECVENNENCKHP 399
Query: 373 PERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDA 432
P S+ GSS E+ C + ++L+GSK +C G+W + P C
Sbjct: 400 PVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKW-SSPPVCLEPCTVN 457
Query: 433 VHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQL 473
V + + G+ + F C++G++L T L
Sbjct: 458 VDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPL 498
Score = 44.7 bits (104), Expect = 3e-04
Identities = 63/291 (21%), Positives = 108/291 (37%), Gaps = 32/291 (10%)
Query: 144 TNTSCSGHGECV--------ETINNYTCKCDPG--FSGLKCEQIVNCTALESPEHGSLVC 193
T+++ HGE V E + +C+ G KC + A E P
Sbjct: 287 THSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGA 346
Query: 194 SHPLGNFSYNSS-CSISCDRGYLPSSMETMQCMSSGEWSAPIPAC--NVVECDAVTNPAN 250
++ YN + +C GYL + C + G+W+ P P C N C N
Sbjct: 347 ANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-NRGKWTLP-PECVENNENCKHPPVVMN 404
Query: 251 GFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQP 310
G V S+ ++ + C E + L G++ +C G W + P C V
Sbjct: 405 GAV-ADGILASYATGSSVEYRCNEYYLLRGSKISRC-EQGKWSSP-PVCLEPCTVNVDYM 461
Query: 311 QNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQ-----GPAQVECTTQGQWTQQIPVCEAF 365
++ G+ +F C++G+ L V+C + + P+C
Sbjct: 462 NRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCN---RGEVKYPLCTRK 518
Query: 366 Q----CTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQC 412
+ CT+ + G + + S ++ GSS E+ C L+GS+ C
Sbjct: 519 ESKGMCTSPPLIKHGVI--ISSTVDTYENGSSVEYRCFDHHFLEGSREAYC 567
>gi|62739188 complement factor H isoform b precursor [Homo sapiens]
Length = 449
Score = 94.7 bits (234), Expect = 2e-19
Identities = 78/294 (26%), Positives = 120/294 (40%), Gaps = 30/294 (10%)
Query: 210 CDRGYLPSSMETMQCMSSGEWSA--PIPACNVVECDAVTNPANGFVECFQNPGS--FPWN 265
C GY M C GEW A P+ C C +P + F G F +
Sbjct: 52 CRPGYRSLGNVIMVCRK-GEWVALNPLRKCQKRPCG---HPGDTPFGTFTLTGGNVFEYG 107
Query: 266 TTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGS-VRCSHSPAGE 324
+ C EG++L+G + + + W N+ P C+ V C V P+NG V + P E
Sbjct: 108 VKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDRE 167
Query: 325 FTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLP-S 383
+ F + F C G+ ++G ++ C+ G W+++ P C C +P+ +N P S
Sbjct: 168 YHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISC---KSPD--VINGSPIS 222
Query: 384 ASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQP--PKGLV 441
++ ++ C G+ C +G W P+CE CD + P +
Sbjct: 223 QKIIYKENERFQYKCNMGYEYSERGDAVCTESG-W-RPLPSCEEKSCDNPYIPNGDYSPL 280
Query: 442 RCAHSPIGEFTYKSSCAFSCEEGF--ELHGSTQLECTSQGQWTEEVPSCQVVKC 493
R H E TY+ C GF G+T +CTS G W P C + C
Sbjct: 281 RIKHRTGDEITYQ------CRNGFYPATRGNT-AKCTSTG-WI-PAPRCTLKPC 325
Score = 87.0 bits (214), Expect = 4e-17
Identities = 62/262 (23%), Positives = 105/262 (40%), Gaps = 14/262 (5%)
Query: 299 CKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQ 358
C A C + +N + + + + C G+ G + C +G+W
Sbjct: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGEWVAL 74
Query: 359 IPV--CEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTG 416
P+ C+ C + G + F YG ++C +G+ L G + T
Sbjct: 75 NPLRKCQKRPCGHPGDTPFGTFTL--TGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD 132
Query: 417 EWDNEKPTCEAVRCDAVHQPPKG-LVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLEC 475
W N+ P CE V+C V P G +V A P E+ + + F C G+++ G ++ C
Sbjct: 133 GWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC 192
Query: 476 TSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVF---GTVCKFACPEGWTLNGSAAR 532
+ G W++E P C + C S P IN S + + ++ C G+ +
Sbjct: 193 SDDGFWSKEKPKCVEISCKS---PDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDA 249
Query: 533 TCGATGHWSGLLPTCEAPTESN 554
C +G W LP+CE + N
Sbjct: 250 VCTESG-WRP-LPSCEEKSCDN 269
Score = 59.7 bits (143), Expect = 8e-09
Identities = 52/215 (24%), Positives = 82/215 (38%), Gaps = 22/215 (10%)
Query: 147 SCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCS--HPLGNFSYNS 204
+C+ + + IN C D + + ++V C + +PE+G +V S P + +
Sbjct: 113 TCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQ 172
Query: 205 SCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPW 264
+ C+ GY E M C G WS P C + C + + NG +
Sbjct: 173 AVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKS-PDVING--SPISQKIIYKE 229
Query: 265 NTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQN--GSVRCSHSPA 322
N + C G+E CT SG W P+C+ +C P +R H
Sbjct: 230 NERFQYKCNMGYEYSERGDAVCTESG-W-RPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287
Query: 323 GEFTFKSSCNFTCEEGFMLQGPA----QVECTTQG 353
E T++ C GF PA +CT+ G
Sbjct: 288 DEITYQ------CRNGFY---PATRGNTAKCTSTG 313
>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
Length = 1231
Score = 94.7 bits (234), Expect = 2e-19
Identities = 78/294 (26%), Positives = 120/294 (40%), Gaps = 30/294 (10%)
Query: 210 CDRGYLPSSMETMQCMSSGEWSA--PIPACNVVECDAVTNPANGFVECFQNPGS--FPWN 265
C GY M C GEW A P+ C C +P + F G F +
Sbjct: 52 CRPGYRSLGNVIMVCRK-GEWVALNPLRKCQKRPCG---HPGDTPFGTFTLTGGNVFEYG 107
Query: 266 TTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGS-VRCSHSPAGE 324
+ C EG++L+G + + + W N+ P C+ V C V P+NG V + P E
Sbjct: 108 VKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDRE 167
Query: 325 FTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLP-S 383
+ F + F C G+ ++G ++ C+ G W+++ P C C +P+ +N P S
Sbjct: 168 YHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISC---KSPD--VINGSPIS 222
Query: 384 ASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQP--PKGLV 441
++ ++ C G+ C +G W P+CE CD + P +
Sbjct: 223 QKIIYKENERFQYKCNMGYEYSERGDAVCTESG-W-RPLPSCEEKSCDNPYIPNGDYSPL 280
Query: 442 RCAHSPIGEFTYKSSCAFSCEEGF--ELHGSTQLECTSQGQWTEEVPSCQVVKC 493
R H E TY+ C GF G+T +CTS G W P C + C
Sbjct: 281 RIKHRTGDEITYQ------CRNGFYPATRGNT-AKCTSTG-WI-PAPRCTLKPC 325
Score = 87.0 bits (214), Expect = 4e-17
Identities = 62/262 (23%), Positives = 105/262 (40%), Gaps = 14/262 (5%)
Query: 299 CKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQ 358
C A C + +N + + + + C G+ G + C +G+W
Sbjct: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGEWVAL 74
Query: 359 IPV--CEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTG 416
P+ C+ C + G + F YG ++C +G+ L G + T
Sbjct: 75 NPLRKCQKRPCGHPGDTPFGTFTL--TGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD 132
Query: 417 EWDNEKPTCEAVRCDAVHQPPKG-LVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLEC 475
W N+ P CE V+C V P G +V A P E+ + + F C G+++ G ++ C
Sbjct: 133 GWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC 192
Query: 476 TSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVF---GTVCKFACPEGWTLNGSAAR 532
+ G W++E P C + C S P IN S + + ++ C G+ +
Sbjct: 193 SDDGFWSKEKPKCVEISCKS---PDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDA 249
Query: 533 TCGATGHWSGLLPTCEAPTESN 554
C +G W LP+CE + N
Sbjct: 250 VCTESG-WRP-LPSCEEKSCDN 269
Score = 82.8 bits (203), Expect = 8e-16
Identities = 91/394 (23%), Positives = 145/394 (36%), Gaps = 57/394 (14%)
Query: 135 LALCYTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNC-------------- 180
L CY N HG + C PG++ K + V C
Sbjct: 386 LRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRV 445
Query: 181 -TALESP---EHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGE--WSAPI 234
T +S E+G + S ++ C GY+ + ET ++ G+ WSA
Sbjct: 446 KTCSKSSIDIENGFI--SESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQ- 502
Query: 235 PACNVVECDAVTNPANGFVECFQN---PGSFPW---NTTCTFDCEEGFEL-MGAQSLQCT 287
P C + CD + F N F W N T ++C +G+E G+ +
Sbjct: 503 PTC-IKSCD---------IPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIV 552
Query: 288 SSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQV 347
N ++ P C C P+ ++ F+C+ GF + GP V
Sbjct: 553 CGYNGWSDLPICYERECEL---PKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSV 609
Query: 348 ECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGS 407
+C G + +P+C+ + PE N + + E+ C F++KG
Sbjct: 610 QCYHFG-LSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGP 668
Query: 408 KRLQCGPTGEWDNEKPTC--EAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGF 465
++QC GEW P C E C + + G + + P + Y S F+C E F
Sbjct: 669 NKIQC-VDGEW-TTLPVCIVEESTCGDIPELEHGWAQLSSPP---YYYGDSVEFNCSESF 723
Query: 466 ELHGSTQLECTSQGQWTEEVPSCQVV----KCSS 495
+ G + C G WT ++P C + KC S
Sbjct: 724 TMIGHRSITCI-HGVWT-QLPQCVAIDKLKKCKS 755
Score = 80.9 bits (198), Expect = 3e-15
Identities = 89/368 (24%), Positives = 145/368 (39%), Gaps = 49/368 (13%)
Query: 200 FSYNSSCSISCDRGYLPSSMETMQCMSSGE--WSAPIPACNVVECDAVTNPANGFVECFQ 257
F N + C GY ++ T + G WS +P C EC+ + + +
Sbjct: 526 FKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWS-DLPICYERECELPKIDVHLVPD--R 582
Query: 258 NPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCK--AVTCRAVRQPQNGSV 315
+ F C+ GF ++G S+QC G + P CK +C + NG+V
Sbjct: 583 KKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFG-LSPDLPICKEQVQSCGPPPELLNGNV 641
Query: 316 RCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVC--EAFQCTALSNP 373
+ E+ + C F+++GP +++C G+WT +PVC E C +
Sbjct: 642 K--EKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWTT-LPVCIVEESTCGDIPEL 697
Query: 374 ERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAV 433
E G+ +S + YG S EF+C + F + G + + C G W + P C A+
Sbjct: 698 EHGWAQL---SSPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVW-TQLPQCVAI----- 747
Query: 434 HQPPKGLVRCAHSPI----------GEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTE 483
L +C S + EF + S+ + C G E G C + G+W
Sbjct: 748 ----DKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRC-RGKE--GWIHTVCIN-GRWDP 799
Query: 484 EVPSCQVVKCSSLAVPGKI----NMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGH 539
EV +C + + P +I NM+ + G C E + + TC G
Sbjct: 800 EV-NCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITC-KDGR 857
Query: 540 WSGLLPTC 547
W +P C
Sbjct: 858 WQS-IPLC 864
Score = 75.1 bits (183), Expect = 2e-13
Identities = 75/344 (21%), Positives = 139/344 (40%), Gaps = 50/344 (14%)
Query: 227 SGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFD--------CEEGFEL 278
+G W P C++ + P Q P S TT + C+E + +
Sbjct: 794 NGRWD-PEVNCSMAQIQLCPPPP-------QIPNSHNMTTTLNYRDGEKVSVLCQENYLI 845
Query: 279 MGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEG 338
+ + C G W + + + C Q ++G++ S S + + ++TCE G
Sbjct: 846 QEGEEITC-KDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGG 904
Query: 339 FMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSC 398
F + + C G+W+ P CE C S PE + + S S++YG + C
Sbjct: 905 FRISEENETTC-YMGKWSSP-PQCEGLPCK--SPPEISH-GVVAHMSDSYQYGEEVTYKC 959
Query: 399 EQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGE--FTYKS- 455
+GF + G +C GE + P+C C ++ + P+GE YK+
Sbjct: 960 FEGFGIDGPAIAKC--LGEKWSHPPSCIKTDCLSLPSFENAI------PMGEKKDVYKAG 1011
Query: 456 -SCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKC-------SSLAVPGKINMSCS 507
++C +++ G++ + C + +WT P+C+ C ++ V +++ S
Sbjct: 1012 EQVTYTCATYYKMDGASNVTCIN-SRWTGR-PTCRDTSCVNPPTVQNAYIVSRQMSKYPS 1069
Query: 508 GEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPT 551
GE V ++ C + + G C G+W+ P C+ T
Sbjct: 1070 GERV-----RYQCRSPYEMFGDEEVMC-LNGNWTE-PPQCKDST 1106
Score = 65.1 bits (157), Expect = 2e-10
Identities = 97/427 (22%), Positives = 150/427 (35%), Gaps = 60/427 (14%)
Query: 147 SCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCS--HPLGNFSYNS 204
+C+ + + IN C D + + ++V C + +PE+G +V S P + +
Sbjct: 113 TCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQ 172
Query: 205 SCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPW 264
+ C+ GY E M C G WS P C + C + + NG +
Sbjct: 173 AVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKS-PDVING--SPISQKIIYKE 229
Query: 265 NTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQN--GSVRCSHSPA 322
N + C G+E CT SG W P+C+ +C P +R H
Sbjct: 230 NERFQYKCNMGYEYSERGDAVCTESG-W-RPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287
Query: 323 GEFTFKSSCNFTCEEGFMLQGPA----QVECTTQGQWTQQIPVCEAFQCTALSNPERG-Y 377
E T++ C GF PA +CT+ G W P C C G Y
Sbjct: 288 DEITYQ------CRNGFY---PATRGNTAKCTSTG-WI-PAPRCTLKPCDYPDIKHGGLY 336
Query: 378 MNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGE-WDNEKPTCEAVRCDAVHQP 436
+ G + C++ F P+G WD+ T + P
Sbjct: 337 HENMRRPYFPVAVGKYYSYYCDEHFET---------PSGSYWDHIHCTQDG------WSP 381
Query: 437 PKGLVRCAHSPIGE----------FTYKSSCAFSCEEGFEL-HGSTQLECTSQGQWTEEV 485
+R + P E F S +C G+ L T + C G W+
Sbjct: 382 AVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WSPTP 440
Query: 486 PSCQVVKCSSLAVPGKINMSCSGEPVFG--TVCKFACPEGW-TLNG--SAARTCGATGHW 540
+V CS ++ + + + K+ C G+ T +G S + TCG G W
Sbjct: 441 RCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDG-W 499
Query: 541 SGLLPTC 547
S PTC
Sbjct: 500 SA-QPTC 505
Score = 63.5 bits (153), Expect = 5e-10
Identities = 72/313 (23%), Positives = 111/313 (35%), Gaps = 35/313 (11%)
Query: 138 CYTAACTNTSCSGHGECVETINNY------TCKCDPGFS----------GLKCEQIVNCT 181
C C + HG ++Y T KC GF G K +C
Sbjct: 926 CEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCI 985
Query: 182 ALESPEHGSLVCSHPLGN----FSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPAC 237
+ S + P+G + + +C Y + C++S W+ P C
Sbjct: 986 KTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINS-RWTGR-PTC 1043
Query: 238 NVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKP 297
C N ++ Q +P + C +E+ G + + C + GNW E P
Sbjct: 1044 RDTSCVNPPTVQNAYIVSRQM-SKYPSGERVRYQCRSPYEMFGDEEVMCLN-GNW-TEPP 1100
Query: 298 TCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQ 357
CK T + P + + P + SS + C+ + L+G ++ C GQW++
Sbjct: 1101 QCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSE 1159
Query: 358 QIPVCEAFQCTALSNPERGYMNCLPSASGSFRY---GSSCEFSCEQGFVLKGSKRLQCGP 414
P C C Y L + Y G S EF C++G+ L S R
Sbjct: 1160 P-PKC-LHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRL--SSRSHTLR 1215
Query: 415 TGEWDN--EKPTC 425
T WD E PTC
Sbjct: 1216 TTCWDGKLEYPTC 1228
>gi|38045915 pregnancy-associated plasma protein A preproprotein [Homo
sapiens]
Length = 1627
Score = 92.0 bits (227), Expect = 1e-18
Identities = 90/355 (25%), Positives = 136/355 (38%), Gaps = 53/355 (14%)
Query: 217 SSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGF 276
SS + + S E S AC +C + N + C + CT C G+
Sbjct: 1190 SSCQRGETYSPAEQSCVHFACEKTDCPELA-VENASLNCSSSDRYH--GAQCTVSCRTGY 1246
Query: 277 --------ELMGAQS-----LQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAG 323
EL+ +Q+ + CT G W N++ C+ V C Q + S P G
Sbjct: 1247 VLQIRRDDELIKSQTGPSVTVTCTE-GKW-NKQVACEPVDCSIPDHHQVYAASFS-CPEG 1303
Query: 324 EFTFKSSCNFTCEEGFMLQGP-AQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLP 382
TF S C+F C L+G + + C G W+ +CE C A +
Sbjct: 1304 T-TFGSQCSFQCRHPAQLKGNNSLLTCMEDGLWSFPEALCE-LMCLAPPPVPNADLQTAR 1361
Query: 383 SASGSFRYGSSCEFSCEQGFVLKGSKR--------LQCGPTGEWDNEKPTCEAVRCDAVH 434
+ GS C++ C+ G+ + GS R QC G W ++ C V CD
Sbjct: 1362 CRENKHKVGSFCKYKCKPGYHVPGSSRKSKKRAFKTQCTQDGSW--QEGACVPVTCDP-- 1417
Query: 435 QPPK--GLVRCAHSPIGEFTYKSSCAFSCEEGFELH--GSTQLECTSQGQWTEEVPSCQV 490
PPK GL +C + F + S C CE+ GS + C G W CQ
Sbjct: 1418 PPPKFHGLYQCTNG----FQFNSECRIKCEDSDASQGLGSNVIHCRKDGTWNGSFHVCQE 1473
Query: 491 VKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLP 545
++ +VP ++N + K CP+G+ + A +C S +LP
Sbjct: 1474 MQ-GQCSVPNELNSN----------LKLQCPDGYAIGSECATSCLDHNSESIILP 1517
Score = 73.6 bits (179), Expect = 5e-13
Identities = 69/262 (26%), Positives = 97/262 (37%), Gaps = 41/262 (15%)
Query: 154 CVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDR- 212
C E N C+P V+C+ + + + S P G ++ S CS C
Sbjct: 1269 CTEGKWNKQVACEP----------VDCSIPDHHQVYAASFSCPEGT-TFGSQCSFQCRHP 1317
Query: 213 GYLPSSMETMQCMSSGEWSAPIPACNVVECDA---VTNPANGFVECFQNP---GSFPWNT 266
L + + CM G WS P C ++ C A V N C +N GSF
Sbjct: 1318 AQLKGNNSLLTCMEDGLWSFPEALCELM-CLAPPPVPNADLQTARCRENKHKVGSF---- 1372
Query: 267 TCTFDCEEGFELMG--------AQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCS 318
C + C+ G+ + G A QCT G+W ++ C VTC +G +C+
Sbjct: 1373 -CKYKCKPGYHVPGSSRKSKKRAFKTQCTQDGSW--QEGACVPVTCDPPPPKFHGLYQCT 1429
Query: 319 HSPAGEFTFKSSCNFTCEEGFMLQGPAQ--VECTTQGQWTQQIPVCEAFQCTALSNPERG 376
+ F F S C CE+ QG + C G W VC+ Q S P
Sbjct: 1430 NG----FQFNSECRIKCEDSDASQGLGSNVIHCRKDGTWNGSFHVCQEMQ-GQCSVPNEL 1484
Query: 377 YMNCLPSASGSFRYGSSCEFSC 398
N + GS C SC
Sbjct: 1485 NSNLKLQCPDGYAIGSECATSC 1506
>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
precursor [Homo sapiens]
Length = 373
Score = 89.7 bits (221), Expect = 7e-18
Identities = 67/239 (28%), Positives = 99/239 (41%), Gaps = 23/239 (9%)
Query: 270 FDCEEGFELMG--AQSLQCTSSGNW-DNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFT 326
+ C++G+ + A C + W C TC +R P NG ++ G +
Sbjct: 62 YKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN---GTYE 118
Query: 327 FKSSCNFTCEEGFMLQGPAQVECTTQGQ---WTQQIPVCEAFQCTALSNPERGYMNCLPS 383
F +F C EG+ L G + C +G W+ + P+CE CT + G S
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTF--S 176
Query: 384 ASGSFRYGSSCEFSCEQG-----FVLKGSKRLQCGPTGEWDNEKPTCEAVRCD-AVHQPP 437
F Y + +SC+ F L G + CG W P C+ V+C V +
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENG 236
Query: 438 KGLVRCAHSPIGE-FTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSS 495
K + S G+ F YK++ F C++GF L GS + C S W VP C V SS
Sbjct: 237 KQI-----SGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSS 290
Score = 87.8 bits (216), Expect = 3e-17
Identities = 65/251 (25%), Positives = 103/251 (41%), Gaps = 27/251 (10%)
Query: 332 NFTCEEGFMLQGPAQVE--CTTQGQWTQQIPV----CEAFQCTALSNPERGYMNCLPSAS 385
++ C++G+ P C W +PV C C + +P G +P A+
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTW---LPVSDDACYRETCPYIRDPLNG--QAVP-AN 114
Query: 386 GSFRYGSSCEFSCEQGFVLKGSKRLQC---GPTGEWDNEKPTCEAVRCDAVHQPPKGLVR 442
G++ +G F C +G+ L G + L C G W + P CE V C PP +
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCT----PPPKIKN 170
Query: 443 CAH--SPIGEFTYKSSCAFSCE-----EGFELHGSTQLECTSQGQWTEEVPSCQVVKCSS 495
H S + F Y + +SC+ + F L G + + C W+ P C+VVKC
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 496 LAVPGKINMSCSGEPVF-GTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESN 554
V +S G+ + F C +G+ L+GS C + W +P C + S+
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSS 290
Query: 555 IPLVAGLSAAG 565
SA+G
Sbjct: 291 TTKSPASSASG 301
Score = 82.8 bits (203), Expect = 8e-16
Identities = 60/241 (24%), Positives = 101/241 (41%), Gaps = 22/241 (9%)
Query: 210 CDRGYL---PSSMETMQCMSSGEWSAPIP--ACNVVECDAVTNPANGFVECFQNPGSFPW 264
C +GY P + T+ C + W P+ AC C + +P NG + G++ +
Sbjct: 64 CKKGYFYIPPLATHTI-CDRNHTW-LPVSDDACYRETCPYIRDPLNG--QAVPANGTYEF 119
Query: 265 NTTCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSP 321
F C EG+ L+G + L C G+ W + P C+ V C + +NG + + S
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNG--KHTFSE 177
Query: 322 AGEFTFKSSCNFTCE-----EGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERG 376
F + + ++C+ + F L G + + C W++ P C+ +C E G
Sbjct: 178 VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR-FPVVENG 236
Query: 377 YMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQP 436
+ F Y ++ F C++GF L GS + C WD P C V + +
Sbjct: 237 KQ--ISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKS 294
Query: 437 P 437
P
Sbjct: 295 P 295
Score = 56.2 bits (134), Expect = 8e-08
Identities = 39/147 (26%), Positives = 62/147 (42%), Gaps = 10/147 (6%)
Query: 174 CEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSME-----TMQCMSSG 228
CE+++ CT ++G S + F Y + + SCD P T+ C +
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSE-VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 229 EWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTS 288
WS P C VV+C + F F + T F+C++GF L G+ ++ C S
Sbjct: 215 VWSRAAPECKVVKCRFPVVENGKQISGFGK--KFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 289 SGNWDNEKPTC-KAVTCRAVRQPQNGS 314
+ WD P C K T + P + +
Sbjct: 273 NSTWDPPVPKCLKVSTSSTTKSPASSA 299
>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
precursor [Homo sapiens]
Length = 370
Score = 89.7 bits (221), Expect = 7e-18
Identities = 67/239 (28%), Positives = 99/239 (41%), Gaps = 23/239 (9%)
Query: 270 FDCEEGFELMG--AQSLQCTSSGNW-DNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFT 326
+ C++G+ + A C + W C TC +R P NG ++ G +
Sbjct: 62 YKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN---GTYE 118
Query: 327 FKSSCNFTCEEGFMLQGPAQVECTTQGQ---WTQQIPVCEAFQCTALSNPERGYMNCLPS 383
F +F C EG+ L G + C +G W+ + P+CE CT + G S
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTF--S 176
Query: 384 ASGSFRYGSSCEFSCEQG-----FVLKGSKRLQCGPTGEWDNEKPTCEAVRCD-AVHQPP 437
F Y + +SC+ F L G + CG W P C+ V+C V +
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENG 236
Query: 438 KGLVRCAHSPIGE-FTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSS 495
K + S G+ F YK++ F C++GF L GS + C S W VP C V SS
Sbjct: 237 KQI-----SGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSS 290
Score = 87.8 bits (216), Expect = 3e-17
Identities = 65/251 (25%), Positives = 103/251 (41%), Gaps = 27/251 (10%)
Query: 332 NFTCEEGFMLQGPAQVE--CTTQGQWTQQIPV----CEAFQCTALSNPERGYMNCLPSAS 385
++ C++G+ P C W +PV C C + +P G +P A+
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTW---LPVSDDACYRETCPYIRDPLNG--QAVP-AN 114
Query: 386 GSFRYGSSCEFSCEQGFVLKGSKRLQC---GPTGEWDNEKPTCEAVRCDAVHQPPKGLVR 442
G++ +G F C +G+ L G + L C G W + P CE V C PP +
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCT----PPPKIKN 170
Query: 443 CAH--SPIGEFTYKSSCAFSCE-----EGFELHGSTQLECTSQGQWTEEVPSCQVVKCSS 495
H S + F Y + +SC+ + F L G + + C W+ P C+VVKC
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 496 LAVPGKINMSCSGEPVF-GTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESN 554
V +S G+ + F C +G+ L+GS C + W +P C + S+
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSS 290
Query: 555 IPLVAGLSAAG 565
SA+G
Sbjct: 291 TTKSPASSASG 301
Score = 82.8 bits (203), Expect = 8e-16
Identities = 60/241 (24%), Positives = 101/241 (41%), Gaps = 22/241 (9%)
Query: 210 CDRGYL---PSSMETMQCMSSGEWSAPIP--ACNVVECDAVTNPANGFVECFQNPGSFPW 264
C +GY P + T+ C + W P+ AC C + +P NG + G++ +
Sbjct: 64 CKKGYFYIPPLATHTI-CDRNHTW-LPVSDDACYRETCPYIRDPLNG--QAVPANGTYEF 119
Query: 265 NTTCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSP 321
F C EG+ L+G + L C G+ W + P C+ V C + +NG + + S
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNG--KHTFSE 177
Query: 322 AGEFTFKSSCNFTCE-----EGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERG 376
F + + ++C+ + F L G + + C W++ P C+ +C E G
Sbjct: 178 VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR-FPVVENG 236
Query: 377 YMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQP 436
+ F Y ++ F C++GF L GS + C WD P C V + +
Sbjct: 237 KQ--ISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKS 294
Query: 437 P 437
P
Sbjct: 295 P 295
Score = 56.2 bits (134), Expect = 8e-08
Identities = 39/147 (26%), Positives = 62/147 (42%), Gaps = 10/147 (6%)
Query: 174 CEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSME-----TMQCMSSG 228
CE+++ CT ++G S + F Y + + SCD P T+ C +
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSE-VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 229 EWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTS 288
WS P C VV+C + F F + T F+C++GF L G+ ++ C S
Sbjct: 215 VWSRAAPECKVVKCRFPVVENGKQISGFGK--KFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 289 SGNWDNEKPTC-KAVTCRAVRQPQNGS 314
+ WD P C K T + P + +
Sbjct: 273 NSTWDPPVPKCLKVSTSSTTKSPASSA 299
>gi|27502415 CD46 antigen, complement regulatory protein isoform 9
precursor [Homo sapiens]
Length = 363
Score = 89.7 bits (221), Expect = 7e-18
Identities = 67/239 (28%), Positives = 99/239 (41%), Gaps = 23/239 (9%)
Query: 270 FDCEEGFELMG--AQSLQCTSSGNW-DNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFT 326
+ C++G+ + A C + W C TC +R P NG ++ G +
Sbjct: 62 YKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN---GTYE 118
Query: 327 FKSSCNFTCEEGFMLQGPAQVECTTQGQ---WTQQIPVCEAFQCTALSNPERGYMNCLPS 383
F +F C EG+ L G + C +G W+ + P+CE CT + G S
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTF--S 176
Query: 384 ASGSFRYGSSCEFSCEQG-----FVLKGSKRLQCGPTGEWDNEKPTCEAVRCD-AVHQPP 437
F Y + +SC+ F L G + CG W P C+ V+C V +
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENG 236
Query: 438 KGLVRCAHSPIGE-FTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSS 495
K + S G+ F YK++ F C++GF L GS + C S W VP C V SS
Sbjct: 237 KQI-----SGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSS 290
Score = 87.8 bits (216), Expect = 3e-17
Identities = 65/251 (25%), Positives = 103/251 (41%), Gaps = 27/251 (10%)
Query: 332 NFTCEEGFMLQGPAQVE--CTTQGQWTQQIPV----CEAFQCTALSNPERGYMNCLPSAS 385
++ C++G+ P C W +PV C C + +P G +P A+
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTW---LPVSDDACYRETCPYIRDPLNG--QAVP-AN 114
Query: 386 GSFRYGSSCEFSCEQGFVLKGSKRLQC---GPTGEWDNEKPTCEAVRCDAVHQPPKGLVR 442
G++ +G F C +G+ L G + L C G W + P CE V C PP +
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCT----PPPKIKN 170
Query: 443 CAH--SPIGEFTYKSSCAFSCE-----EGFELHGSTQLECTSQGQWTEEVPSCQVVKCSS 495
H S + F Y + +SC+ + F L G + + C W+ P C+VVKC
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 496 LAVPGKINMSCSGEPVF-GTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESN 554
V +S G+ + F C +G+ L+GS C + W +P C + S+
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSS 290
Query: 555 IPLVAGLSAAG 565
SA+G
Sbjct: 291 TTKSPASSASG 301
Score = 82.8 bits (203), Expect = 8e-16
Identities = 60/241 (24%), Positives = 101/241 (41%), Gaps = 22/241 (9%)
Query: 210 CDRGYL---PSSMETMQCMSSGEWSAPIP--ACNVVECDAVTNPANGFVECFQNPGSFPW 264
C +GY P + T+ C + W P+ AC C + +P NG + G++ +
Sbjct: 64 CKKGYFYIPPLATHTI-CDRNHTW-LPVSDDACYRETCPYIRDPLNG--QAVPANGTYEF 119
Query: 265 NTTCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSP 321
F C EG+ L+G + L C G+ W + P C+ V C + +NG + + S
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNG--KHTFSE 177
Query: 322 AGEFTFKSSCNFTCE-----EGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERG 376
F + + ++C+ + F L G + + C W++ P C+ +C E G
Sbjct: 178 VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR-FPVVENG 236
Query: 377 YMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQP 436
+ F Y ++ F C++GF L GS + C WD P C V + +
Sbjct: 237 KQ--ISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKS 294
Query: 437 P 437
P
Sbjct: 295 P 295
Score = 56.2 bits (134), Expect = 8e-08
Identities = 39/147 (26%), Positives = 62/147 (42%), Gaps = 10/147 (6%)
Query: 174 CEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSME-----TMQCMSSG 228
CE+++ CT ++G S + F Y + + SCD P T+ C +
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSE-VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 229 EWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTS 288
WS P C VV+C + F F + T F+C++GF L G+ ++ C S
Sbjct: 215 VWSRAAPECKVVKCRFPVVENGKQISGFGK--KFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 289 SGNWDNEKPTC-KAVTCRAVRQPQNGS 314
+ WD P C K T + P + +
Sbjct: 273 NSTWDPPVPKCLKVSTSSTTKSPASSA 299
>gi|27502407 CD46 antigen, complement regulatory protein isoform 3
precursor [Homo sapiens]
Length = 377
Score = 89.7 bits (221), Expect = 7e-18
Identities = 67/239 (28%), Positives = 99/239 (41%), Gaps = 23/239 (9%)
Query: 270 FDCEEGFELMG--AQSLQCTSSGNW-DNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFT 326
+ C++G+ + A C + W C TC +R P NG ++ G +
Sbjct: 62 YKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN---GTYE 118
Query: 327 FKSSCNFTCEEGFMLQGPAQVECTTQGQ---WTQQIPVCEAFQCTALSNPERGYMNCLPS 383
F +F C EG+ L G + C +G W+ + P+CE CT + G S
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTF--S 176
Query: 384 ASGSFRYGSSCEFSCEQG-----FVLKGSKRLQCGPTGEWDNEKPTCEAVRCD-AVHQPP 437
F Y + +SC+ F L G + CG W P C+ V+C V +
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENG 236
Query: 438 KGLVRCAHSPIGE-FTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSS 495
K + S G+ F YK++ F C++GF L GS + C S W VP C V SS
Sbjct: 237 KQI-----SGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSS 290
Score = 87.8 bits (216), Expect = 3e-17
Identities = 65/251 (25%), Positives = 103/251 (41%), Gaps = 27/251 (10%)
Query: 332 NFTCEEGFMLQGPAQVE--CTTQGQWTQQIPV----CEAFQCTALSNPERGYMNCLPSAS 385
++ C++G+ P C W +PV C C + +P G +P A+
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTW---LPVSDDACYRETCPYIRDPLNG--QAVP-AN 114
Query: 386 GSFRYGSSCEFSCEQGFVLKGSKRLQC---GPTGEWDNEKPTCEAVRCDAVHQPPKGLVR 442
G++ +G F C +G+ L G + L C G W + P CE V C PP +
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCT----PPPKIKN 170
Query: 443 CAH--SPIGEFTYKSSCAFSCE-----EGFELHGSTQLECTSQGQWTEEVPSCQVVKCSS 495
H S + F Y + +SC+ + F L G + + C W+ P C+VVKC
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 496 LAVPGKINMSCSGEPVF-GTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESN 554
V +S G+ + F C +G+ L+GS C + W +P C + S+
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSS 290
Query: 555 IPLVAGLSAAG 565
SA+G
Sbjct: 291 TTKSPASSASG 301
Score = 82.8 bits (203), Expect = 8e-16
Identities = 60/241 (24%), Positives = 101/241 (41%), Gaps = 22/241 (9%)
Query: 210 CDRGYL---PSSMETMQCMSSGEWSAPIP--ACNVVECDAVTNPANGFVECFQNPGSFPW 264
C +GY P + T+ C + W P+ AC C + +P NG + G++ +
Sbjct: 64 CKKGYFYIPPLATHTI-CDRNHTW-LPVSDDACYRETCPYIRDPLNG--QAVPANGTYEF 119
Query: 265 NTTCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSP 321
F C EG+ L+G + L C G+ W + P C+ V C + +NG + + S
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNG--KHTFSE 177
Query: 322 AGEFTFKSSCNFTCE-----EGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERG 376
F + + ++C+ + F L G + + C W++ P C+ +C E G
Sbjct: 178 VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR-FPVVENG 236
Query: 377 YMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQP 436
+ F Y ++ F C++GF L GS + C WD P C V + +
Sbjct: 237 KQ--ISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKS 294
Query: 437 P 437
P
Sbjct: 295 P 295
Score = 56.2 bits (134), Expect = 8e-08
Identities = 39/147 (26%), Positives = 62/147 (42%), Gaps = 10/147 (6%)
Query: 174 CEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSME-----TMQCMSSG 228
CE+++ CT ++G S + F Y + + SCD P T+ C +
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSE-VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 229 EWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTS 288
WS P C VV+C + F F + T F+C++GF L G+ ++ C S
Sbjct: 215 VWSRAAPECKVVKCRFPVVENGKQISGFGK--KFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 289 SGNWDNEKPTC-KAVTCRAVRQPQNGS 314
+ WD P C K T + P + +
Sbjct: 273 NSTWDPPVPKCLKVSTSSTTKSPASSA 299
>gi|24432108 CD46 antigen, complement regulatory protein isoform 4
precursor [Homo sapiens]
Length = 384
Score = 89.7 bits (221), Expect = 7e-18
Identities = 67/239 (28%), Positives = 99/239 (41%), Gaps = 23/239 (9%)
Query: 270 FDCEEGFELMG--AQSLQCTSSGNW-DNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFT 326
+ C++G+ + A C + W C TC +R P NG ++ G +
Sbjct: 62 YKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN---GTYE 118
Query: 327 FKSSCNFTCEEGFMLQGPAQVECTTQGQ---WTQQIPVCEAFQCTALSNPERGYMNCLPS 383
F +F C EG+ L G + C +G W+ + P+CE CT + G S
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTF--S 176
Query: 384 ASGSFRYGSSCEFSCEQG-----FVLKGSKRLQCGPTGEWDNEKPTCEAVRCD-AVHQPP 437
F Y + +SC+ F L G + CG W P C+ V+C V +
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENG 236
Query: 438 KGLVRCAHSPIGE-FTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSS 495
K + S G+ F YK++ F C++GF L GS + C S W VP C V SS
Sbjct: 237 KQI-----SGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSS 290
Score = 87.8 bits (216), Expect = 3e-17
Identities = 65/251 (25%), Positives = 103/251 (41%), Gaps = 27/251 (10%)
Query: 332 NFTCEEGFMLQGPAQVE--CTTQGQWTQQIPV----CEAFQCTALSNPERGYMNCLPSAS 385
++ C++G+ P C W +PV C C + +P G +P A+
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTW---LPVSDDACYRETCPYIRDPLNG--QAVP-AN 114
Query: 386 GSFRYGSSCEFSCEQGFVLKGSKRLQC---GPTGEWDNEKPTCEAVRCDAVHQPPKGLVR 442
G++ +G F C +G+ L G + L C G W + P CE V C PP +
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCT----PPPKIKN 170
Query: 443 CAH--SPIGEFTYKSSCAFSCE-----EGFELHGSTQLECTSQGQWTEEVPSCQVVKCSS 495
H S + F Y + +SC+ + F L G + + C W+ P C+VVKC
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 496 LAVPGKINMSCSGEPVF-GTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESN 554
V +S G+ + F C +G+ L+GS C + W +P C + S+
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSS 290
Query: 555 IPLVAGLSAAG 565
SA+G
Sbjct: 291 TTKSPASSASG 301
Score = 82.8 bits (203), Expect = 8e-16
Identities = 60/241 (24%), Positives = 101/241 (41%), Gaps = 22/241 (9%)
Query: 210 CDRGYL---PSSMETMQCMSSGEWSAPIP--ACNVVECDAVTNPANGFVECFQNPGSFPW 264
C +GY P + T+ C + W P+ AC C + +P NG + G++ +
Sbjct: 64 CKKGYFYIPPLATHTI-CDRNHTW-LPVSDDACYRETCPYIRDPLNG--QAVPANGTYEF 119
Query: 265 NTTCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSP 321
F C EG+ L+G + L C G+ W + P C+ V C + +NG + + S
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNG--KHTFSE 177
Query: 322 AGEFTFKSSCNFTCE-----EGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERG 376
F + + ++C+ + F L G + + C W++ P C+ +C E G
Sbjct: 178 VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCR-FPVVENG 236
Query: 377 YMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQP 436
+ F Y ++ F C++GF L GS + C WD P C V + +
Sbjct: 237 KQ--ISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKS 294
Query: 437 P 437
P
Sbjct: 295 P 295
Score = 56.2 bits (134), Expect = 8e-08
Identities = 39/147 (26%), Positives = 62/147 (42%), Gaps = 10/147 (6%)
Query: 174 CEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSME-----TMQCMSSG 228
CE+++ CT ++G S + F Y + + SCD P T+ C +
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSE-VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 229 EWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTS 288
WS P C VV+C + F F + T F+C++GF L G+ ++ C S
Sbjct: 215 VWSRAAPECKVVKCRFPVVENGKQISGFGK--KFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 289 SGNWDNEKPTC-KAVTCRAVRQPQNGS 314
+ WD P C K T + P + +
Sbjct: 273 NSTWDPPVPKCLKVSTSSTTKSPASSA 299
>gi|27502413 CD46 antigen, complement regulatory protein isoform 7
precursor [Homo sapiens]
Length = 378
Score = 89.4 bits (220), Expect = 9e-18
Identities = 69/251 (27%), Positives = 103/251 (41%), Gaps = 23/251 (9%)
Query: 270 FDCEEGFELMG--AQSLQCTSSGNW-DNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFT 326
+ C++G+ + A C + W C TC +R P NG ++ G +
Sbjct: 62 YKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN---GTYE 118
Query: 327 FKSSCNFTCEEGFMLQGPAQVECTTQGQ---WTQQIPVCEAFQCTALSNPERGYMNCLPS 383
F +F C EG+ L G + C +G W+ + P+CE CT + G S
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTF--S 176
Query: 384 ASGSFRYGSSCEFSCEQG-----FVLKGSKRLQCGPTGEWDNEKPTCEAVRCD-AVHQPP 437
F Y + +SC+ F L G + CG W P C+ V+C V +
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENG 236
Query: 438 KGLVRCAHSPIGE-FTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSL 496
K + S G+ F YK++ F C++GF L GS + C S W VP C V S
Sbjct: 237 KQI-----SGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSS 291
Query: 497 AVPGKINMSCS 507
P ++ S S
Sbjct: 292 TKPPALSHSVS 302
Score = 85.9 bits (211), Expect = 1e-16
Identities = 61/233 (26%), Positives = 96/233 (41%), Gaps = 27/233 (11%)
Query: 332 NFTCEEGFMLQGPAQVE--CTTQGQWTQQIPV----CEAFQCTALSNPERGYMNCLPSAS 385
++ C++G+ P C W +PV C C + +P G +P A+
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTW---LPVSDDACYRETCPYIRDPLNG--QAVP-AN 114
Query: 386 GSFRYGSSCEFSCEQGFVLKGSKRLQC---GPTGEWDNEKPTCEAVRCDAVHQPPKGLVR 442
G++ +G F C +G+ L G + L C G W + P CE V C PP +
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCT----PPPKIKN 170
Query: 443 CAH--SPIGEFTYKSSCAFSCE-----EGFELHGSTQLECTSQGQWTEEVPSCQVVKCSS 495
H S + F Y + +SC+ + F L G + + C W+ P C+VVKC
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 496 LAVPGKINMSCSGEPVF-GTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTC 547
V +S G+ + F C +G+ L+GS C + W +P C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 83.6 bits (205), Expect = 5e-16
Identities = 60/243 (24%), Positives = 104/243 (42%), Gaps = 26/243 (10%)
Query: 210 CDRGYL---PSSMETMQCMSSGEWSAPIP--ACNVVECDAVTNPANGFVECFQNPGSFPW 264
C +GY P + T+ C + W P+ AC C + +P NG + G++ +
Sbjct: 64 CKKGYFYIPPLATHTI-CDRNHTW-LPVSDDACYRETCPYIRDPLNG--QAVPANGTYEF 119
Query: 265 NTTCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSP 321
F C EG+ L+G + L C G+ W + P C+ V C + +NG + + S
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNG--KHTFSE 177
Query: 322 AGEFTFKSSCNFTCE-----EGFMLQGPAQVECTTQGQWTQQIPVCEAFQC--TALSNPE 374
F + + ++C+ + F L G + + C W++ P C+ +C + N +
Sbjct: 178 VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGK 237
Query: 375 RGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVH 434
+ + F Y ++ F C++GF L GS + C WD P C V +
Sbjct: 238 Q-----ISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSST 292
Query: 435 QPP 437
+PP
Sbjct: 293 KPP 295
Score = 57.0 bits (136), Expect = 5e-08
Identities = 44/161 (27%), Positives = 67/161 (41%), Gaps = 13/161 (8%)
Query: 174 CEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSME-----TMQCMSSG 228
CE+++ CT ++G S + F Y + + SCD P T+ C +
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSE-VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 229 EWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTS 288
WS P C VV+C + F F + T F+C++GF L G+ ++ C S
Sbjct: 215 VWSRAAPECKVVKCRFPVVENGKQISGFGK--KFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 289 SGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKS 329
+ WD P C V + +P SHS + T KS
Sbjct: 273 NSTWDPPVPKCLKVLPPSSTKPP----ALSHSVSTSSTTKS 309
Score = 43.9 bits (102), Expect = 4e-04
Identities = 41/180 (22%), Positives = 68/180 (37%), Gaps = 28/180 (15%)
Query: 388 FRYGSSCEFSCEQGF--VLKGSKRLQCGPTGEW-DNEKPTCEAVRCDAVHQPPKGLVRCA 444
+ G ++ C++G+ + + C W C C + P G A
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 445 HSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ---WTEEVPSCQVVKCSSLAVPGK 501
+ G + + F C EG+ L G L C +G W+ + P C+ V C+ P K
Sbjct: 114 N---GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTP---PPK 167
Query: 502 INMSCSGEPVFGTV--------CKFAC-----PEGWTLNGSAARTCGATGHWSGLLPTCE 548
I +G+ F V ++C P+ ++L G + CG WS P C+
Sbjct: 168 IK---NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
>gi|27502402 CD46 antigen, complement regulatory protein isoform 1
precursor [Homo sapiens]
Length = 392
Score = 89.4 bits (220), Expect = 9e-18
Identities = 69/251 (27%), Positives = 103/251 (41%), Gaps = 23/251 (9%)
Query: 270 FDCEEGFELMG--AQSLQCTSSGNW-DNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFT 326
+ C++G+ + A C + W C TC +R P NG ++ G +
Sbjct: 62 YKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN---GTYE 118
Query: 327 FKSSCNFTCEEGFMLQGPAQVECTTQGQ---WTQQIPVCEAFQCTALSNPERGYMNCLPS 383
F +F C EG+ L G + C +G W+ + P+CE CT + G S
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTF--S 176
Query: 384 ASGSFRYGSSCEFSCEQG-----FVLKGSKRLQCGPTGEWDNEKPTCEAVRCD-AVHQPP 437
F Y + +SC+ F L G + CG W P C+ V+C V +
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENG 236
Query: 438 KGLVRCAHSPIGE-FTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSL 496
K + S G+ F YK++ F C++GF L GS + C S W VP C V S
Sbjct: 237 KQI-----SGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSS 291
Query: 497 AVPGKINMSCS 507
P ++ S S
Sbjct: 292 TKPPALSHSVS 302
Score = 85.9 bits (211), Expect = 1e-16
Identities = 61/233 (26%), Positives = 96/233 (41%), Gaps = 27/233 (11%)
Query: 332 NFTCEEGFMLQGPAQVE--CTTQGQWTQQIPV----CEAFQCTALSNPERGYMNCLPSAS 385
++ C++G+ P C W +PV C C + +P G +P A+
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTW---LPVSDDACYRETCPYIRDPLNG--QAVP-AN 114
Query: 386 GSFRYGSSCEFSCEQGFVLKGSKRLQC---GPTGEWDNEKPTCEAVRCDAVHQPPKGLVR 442
G++ +G F C +G+ L G + L C G W + P CE V C PP +
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCT----PPPKIKN 170
Query: 443 CAH--SPIGEFTYKSSCAFSCE-----EGFELHGSTQLECTSQGQWTEEVPSCQVVKCSS 495
H S + F Y + +SC+ + F L G + + C W+ P C+VVKC
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 496 LAVPGKINMSCSGEPVF-GTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTC 547
V +S G+ + F C +G+ L+GS C + W +P C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 83.6 bits (205), Expect = 5e-16
Identities = 60/243 (24%), Positives = 104/243 (42%), Gaps = 26/243 (10%)
Query: 210 CDRGYL---PSSMETMQCMSSGEWSAPIP--ACNVVECDAVTNPANGFVECFQNPGSFPW 264
C +GY P + T+ C + W P+ AC C + +P NG + G++ +
Sbjct: 64 CKKGYFYIPPLATHTI-CDRNHTW-LPVSDDACYRETCPYIRDPLNG--QAVPANGTYEF 119
Query: 265 NTTCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSP 321
F C EG+ L+G + L C G+ W + P C+ V C + +NG + + S
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNG--KHTFSE 177
Query: 322 AGEFTFKSSCNFTCE-----EGFMLQGPAQVECTTQGQWTQQIPVCEAFQC--TALSNPE 374
F + + ++C+ + F L G + + C W++ P C+ +C + N +
Sbjct: 178 VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGK 237
Query: 375 RGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVH 434
+ + F Y ++ F C++GF L GS + C WD P C V +
Sbjct: 238 Q-----ISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSST 292
Query: 435 QPP 437
+PP
Sbjct: 293 KPP 295
Score = 57.0 bits (136), Expect = 5e-08
Identities = 44/161 (27%), Positives = 67/161 (41%), Gaps = 13/161 (8%)
Query: 174 CEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSME-----TMQCMSSG 228
CE+++ CT ++G S + F Y + + SCD P T+ C +
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSE-VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 229 EWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTS 288
WS P C VV+C + F F + T F+C++GF L G+ ++ C S
Sbjct: 215 VWSRAAPECKVVKCRFPVVENGKQISGFGK--KFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 289 SGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKS 329
+ WD P C V + +P SHS + T KS
Sbjct: 273 NSTWDPPVPKCLKVLPPSSTKPP----ALSHSVSTSSTTKS 309
Score = 43.9 bits (102), Expect = 4e-04
Identities = 41/180 (22%), Positives = 68/180 (37%), Gaps = 28/180 (15%)
Query: 388 FRYGSSCEFSCEQGF--VLKGSKRLQCGPTGEW-DNEKPTCEAVRCDAVHQPPKGLVRCA 444
+ G ++ C++G+ + + C W C C + P G A
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 445 HSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ---WTEEVPSCQVVKCSSLAVPGK 501
+ G + + F C EG+ L G L C +G W+ + P C+ V C+ P K
Sbjct: 114 N---GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTP---PPK 167
Query: 502 INMSCSGEPVFGTV--------CKFAC-----PEGWTLNGSAARTCGATGHWSGLLPTCE 548
I +G+ F V ++C P+ ++L G + CG WS P C+
Sbjct: 168 IK---NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
>gi|27502425 CD46 antigen, complement regulatory protein isoform 8
precursor [Homo sapiens]
Length = 385
Score = 89.4 bits (220), Expect = 9e-18
Identities = 69/251 (27%), Positives = 103/251 (41%), Gaps = 23/251 (9%)
Query: 270 FDCEEGFELMG--AQSLQCTSSGNW-DNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFT 326
+ C++G+ + A C + W C TC +R P NG ++ G +
Sbjct: 62 YKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN---GTYE 118
Query: 327 FKSSCNFTCEEGFMLQGPAQVECTTQGQ---WTQQIPVCEAFQCTALSNPERGYMNCLPS 383
F +F C EG+ L G + C +G W+ + P+CE CT + G S
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTF--S 176
Query: 384 ASGSFRYGSSCEFSCEQG-----FVLKGSKRLQCGPTGEWDNEKPTCEAVRCD-AVHQPP 437
F Y + +SC+ F L G + CG W P C+ V+C V +
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENG 236
Query: 438 KGLVRCAHSPIGE-FTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSL 496
K + S G+ F YK++ F C++GF L GS + C S W VP C V S
Sbjct: 237 KQI-----SGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSS 291
Query: 497 AVPGKINMSCS 507
P ++ S S
Sbjct: 292 TKPPALSHSVS 302
Score = 85.9 bits (211), Expect = 1e-16
Identities = 61/233 (26%), Positives = 96/233 (41%), Gaps = 27/233 (11%)
Query: 332 NFTCEEGFMLQGPAQVE--CTTQGQWTQQIPV----CEAFQCTALSNPERGYMNCLPSAS 385
++ C++G+ P C W +PV C C + +P G +P A+
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTW---LPVSDDACYRETCPYIRDPLNG--QAVP-AN 114
Query: 386 GSFRYGSSCEFSCEQGFVLKGSKRLQC---GPTGEWDNEKPTCEAVRCDAVHQPPKGLVR 442
G++ +G F C +G+ L G + L C G W + P CE V C PP +
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCT----PPPKIKN 170
Query: 443 CAH--SPIGEFTYKSSCAFSCE-----EGFELHGSTQLECTSQGQWTEEVPSCQVVKCSS 495
H S + F Y + +SC+ + F L G + + C W+ P C+VVKC
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 496 LAVPGKINMSCSGEPVF-GTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTC 547
V +S G+ + F C +G+ L+GS C + W +P C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 83.6 bits (205), Expect = 5e-16
Identities = 60/243 (24%), Positives = 104/243 (42%), Gaps = 26/243 (10%)
Query: 210 CDRGYL---PSSMETMQCMSSGEWSAPIP--ACNVVECDAVTNPANGFVECFQNPGSFPW 264
C +GY P + T+ C + W P+ AC C + +P NG + G++ +
Sbjct: 64 CKKGYFYIPPLATHTI-CDRNHTW-LPVSDDACYRETCPYIRDPLNG--QAVPANGTYEF 119
Query: 265 NTTCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSP 321
F C EG+ L+G + L C G+ W + P C+ V C + +NG + + S
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNG--KHTFSE 177
Query: 322 AGEFTFKSSCNFTCE-----EGFMLQGPAQVECTTQGQWTQQIPVCEAFQC--TALSNPE 374
F + + ++C+ + F L G + + C W++ P C+ +C + N +
Sbjct: 178 VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGK 237
Query: 375 RGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVH 434
+ + F Y ++ F C++GF L GS + C WD P C V +
Sbjct: 238 Q-----ISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSST 292
Query: 435 QPP 437
+PP
Sbjct: 293 KPP 295
Score = 57.0 bits (136), Expect = 5e-08
Identities = 44/161 (27%), Positives = 67/161 (41%), Gaps = 13/161 (8%)
Query: 174 CEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSME-----TMQCMSSG 228
CE+++ CT ++G S + F Y + + SCD P T+ C +
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSE-VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 229 EWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTS 288
WS P C VV+C + F F + T F+C++GF L G+ ++ C S
Sbjct: 215 VWSRAAPECKVVKCRFPVVENGKQISGFGK--KFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 289 SGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKS 329
+ WD P C V + +P SHS + T KS
Sbjct: 273 NSTWDPPVPKCLKVLPPSSTKPP----ALSHSVSTSSTTKS 309
Score = 43.9 bits (102), Expect = 4e-04
Identities = 41/180 (22%), Positives = 68/180 (37%), Gaps = 28/180 (15%)
Query: 388 FRYGSSCEFSCEQGF--VLKGSKRLQCGPTGEW-DNEKPTCEAVRCDAVHQPPKGLVRCA 444
+ G ++ C++G+ + + C W C C + P G A
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 445 HSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ---WTEEVPSCQVVKCSSLAVPGK 501
+ G + + F C EG+ L G L C +G W+ + P C+ V C+ P K
Sbjct: 114 N---GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTP---PPK 167
Query: 502 INMSCSGEPVFGTV--------CKFAC-----PEGWTLNGSAARTCGATGHWSGLLPTCE 548
I +G+ F V ++C P+ ++L G + CG WS P C+
Sbjct: 168 IK---NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
>gi|27502423 CD46 antigen, complement regulatory protein isoform 2
precursor [Homo sapiens]
Length = 399
Score = 89.4 bits (220), Expect = 9e-18
Identities = 69/251 (27%), Positives = 103/251 (41%), Gaps = 23/251 (9%)
Query: 270 FDCEEGFELMG--AQSLQCTSSGNW-DNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFT 326
+ C++G+ + A C + W C TC +R P NG ++ G +
Sbjct: 62 YKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPAN---GTYE 118
Query: 327 FKSSCNFTCEEGFMLQGPAQVECTTQGQ---WTQQIPVCEAFQCTALSNPERGYMNCLPS 383
F +F C EG+ L G + C +G W+ + P+CE CT + G S
Sbjct: 119 FGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTF--S 176
Query: 384 ASGSFRYGSSCEFSCEQG-----FVLKGSKRLQCGPTGEWDNEKPTCEAVRCD-AVHQPP 437
F Y + +SC+ F L G + CG W P C+ V+C V +
Sbjct: 177 EVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENG 236
Query: 438 KGLVRCAHSPIGE-FTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSL 496
K + S G+ F YK++ F C++GF L GS + C S W VP C V S
Sbjct: 237 KQI-----SGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSS 291
Query: 497 AVPGKINMSCS 507
P ++ S S
Sbjct: 292 TKPPALSHSVS 302
Score = 85.9 bits (211), Expect = 1e-16
Identities = 61/233 (26%), Positives = 96/233 (41%), Gaps = 27/233 (11%)
Query: 332 NFTCEEGFMLQGPAQVE--CTTQGQWTQQIPV----CEAFQCTALSNPERGYMNCLPSAS 385
++ C++G+ P C W +PV C C + +P G +P A+
Sbjct: 61 DYKCKKGYFYIPPLATHTICDRNHTW---LPVSDDACYRETCPYIRDPLNG--QAVP-AN 114
Query: 386 GSFRYGSSCEFSCEQGFVLKGSKRLQC---GPTGEWDNEKPTCEAVRCDAVHQPPKGLVR 442
G++ +G F C +G+ L G + L C G W + P CE V C PP +
Sbjct: 115 GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCT----PPPKIKN 170
Query: 443 CAH--SPIGEFTYKSSCAFSCE-----EGFELHGSTQLECTSQGQWTEEVPSCQVVKCSS 495
H S + F Y + +SC+ + F L G + + C W+ P C+VVKC
Sbjct: 171 GKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRF 230
Query: 496 LAVPGKINMSCSGEPVF-GTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTC 547
V +S G+ + F C +G+ L+GS C + W +P C
Sbjct: 231 PVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 83.6 bits (205), Expect = 5e-16
Identities = 60/243 (24%), Positives = 104/243 (42%), Gaps = 26/243 (10%)
Query: 210 CDRGYL---PSSMETMQCMSSGEWSAPIP--ACNVVECDAVTNPANGFVECFQNPGSFPW 264
C +GY P + T+ C + W P+ AC C + +P NG + G++ +
Sbjct: 64 CKKGYFYIPPLATHTI-CDRNHTW-LPVSDDACYRETCPYIRDPLNG--QAVPANGTYEF 119
Query: 265 NTTCTFDCEEGFELMGAQSLQCTSSGN---WDNEKPTCKAVTCRAVRQPQNGSVRCSHSP 321
F C EG+ L+G + L C G+ W + P C+ V C + +NG + + S
Sbjct: 120 GYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNG--KHTFSE 177
Query: 322 AGEFTFKSSCNFTCE-----EGFMLQGPAQVECTTQGQWTQQIPVCEAFQC--TALSNPE 374
F + + ++C+ + F L G + + C W++ P C+ +C + N +
Sbjct: 178 VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGK 237
Query: 375 RGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVH 434
+ + F Y ++ F C++GF L GS + C WD P C V +
Sbjct: 238 Q-----ISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSST 292
Query: 435 QPP 437
+PP
Sbjct: 293 KPP 295
Score = 57.0 bits (136), Expect = 5e-08
Identities = 44/161 (27%), Positives = 67/161 (41%), Gaps = 13/161 (8%)
Query: 174 CEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSME-----TMQCMSSG 228
CE+++ CT ++G S + F Y + + SCD P T+ C +
Sbjct: 157 CEKVL-CTPPPKIKNGKHTFSE-VEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNS 214
Query: 229 EWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTS 288
WS P C VV+C + F F + T F+C++GF L G+ ++ C S
Sbjct: 215 VWSRAAPECKVVKCRFPVVENGKQISGFGK--KFYYKATVMFECDKGFYLDGSDTIVCDS 272
Query: 289 SGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKS 329
+ WD P C V + +P SHS + T KS
Sbjct: 273 NSTWDPPVPKCLKVLPPSSTKPP----ALSHSVSTSSTTKS 309
Score = 43.9 bits (102), Expect = 4e-04
Identities = 41/180 (22%), Positives = 68/180 (37%), Gaps = 28/180 (15%)
Query: 388 FRYGSSCEFSCEQGF--VLKGSKRLQCGPTGEW-DNEKPTCEAVRCDAVHQPPKGLVRCA 444
+ G ++ C++G+ + + C W C C + P G A
Sbjct: 54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPA 113
Query: 445 HSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ---WTEEVPSCQVVKCSSLAVPGK 501
+ G + + F C EG+ L G L C +G W+ + P C+ V C+ P K
Sbjct: 114 N---GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTP---PPK 167
Query: 502 INMSCSGEPVFGTV--------CKFAC-----PEGWTLNGSAARTCGATGHWSGLLPTCE 548
I +G+ F V ++C P+ ++L G + CG WS P C+
Sbjct: 168 IK---NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECK 224
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.131 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,202,899
Number of Sequences: 37866
Number of extensions: 1474164
Number of successful extensions: 7493
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 208
Number of HSP's successfully gapped in prelim test: 208
Number of HSP's that attempted gapping in prelim test: 3235
Number of HSP's gapped (non-prelim): 2062
length of query: 610
length of database: 18,247,518
effective HSP length: 108
effective length of query: 502
effective length of database: 14,157,990
effective search space: 7107310980
effective search space used: 7107310980
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.