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Search of human proteins with 103471993
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|103471993 huntingtin interacting protein 14 [Homo sapiens]
(632 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|103471993 huntingtin interacting protein 14 [Homo sapiens] 1343 0.0
gi|47933346 zinc finger, DHHC domain containing 13 isoform 1 [Ho... 617 e-177
gi|47933348 zinc finger, DHHC domain containing 13 isoform 2 [Ho... 462 e-130
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 112 1e-24
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 101 2e-21
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 101 2e-21
gi|18079216 CASK interacting protein 1 [Homo sapiens] 100 7e-21
gi|197304690 zinc finger, DHHC-type containing 4 [Homo sapiens] 98 3e-20
gi|197304688 zinc finger, DHHC-type containing 4 [Homo sapiens] 98 3e-20
gi|197304686 zinc finger, DHHC-type containing 4 [Homo sapiens] 98 3e-20
gi|8922448 zinc finger, DHHC-type containing 4 [Homo sapiens] 98 3e-20
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 97 5e-20
gi|37594451 Abl-philin 2 isoform 2 [Homo sapiens] 95 2e-19
gi|37594447 Abl-philin 2 isoform 4 [Homo sapiens] 95 2e-19
gi|41152072 zinc finger, DHHC domain containing 5 [Homo sapiens] 94 3e-19
gi|30348954 mindbomb homolog 1 [Homo sapiens] 93 7e-19
gi|21361910 zinc finger, DHHC domain containing 12 [Homo sapiens] 93 8e-19
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 92 1e-18
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 91 2e-18
gi|37594449 Abl-philin 2 isoform 1 [Homo sapiens] 91 3e-18
gi|37594455 Abl-philin 2 isoform 1 [Homo sapiens] 91 3e-18
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 90 6e-18
gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 89 2e-17
gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 89 2e-17
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens] 88 2e-17
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 88 3e-17
gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 87 4e-17
gi|148596917 fibronectin type III and ankyrin repeat domains 1 [... 87 4e-17
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 87 6e-17
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 87 6e-17
>gi|103471993 huntingtin interacting protein 14 [Homo sapiens]
Length = 632
Score = 1343 bits (3476), Expect = 0.0
Identities = 632/632 (100%), Positives = 632/632 (100%)
Query: 1 MQREEGFNTKMADGPDEYDTEAGCVPLLHPEEIKPQSHYNHGYGEPLGRKTHIDDYSTWD 60
MQREEGFNTKMADGPDEYDTEAGCVPLLHPEEIKPQSHYNHGYGEPLGRKTHIDDYSTWD
Sbjct: 1 MQREEGFNTKMADGPDEYDTEAGCVPLLHPEEIKPQSHYNHGYGEPLGRKTHIDDYSTWD 60
Query: 61 IVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLG 120
IVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLG
Sbjct: 61 IVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLG 120
Query: 121 GDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKG 180
GDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKG
Sbjct: 121 GDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKG 180
Query: 181 QDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTV 240
QDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTV
Sbjct: 181 QDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTV 240
Query: 241 ISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKLKADKE 300
ISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKLKADKE
Sbjct: 241 ISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKLKADKE 300
Query: 301 FRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPL 360
FRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPL
Sbjct: 301 FRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPL 360
Query: 361 GIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQK 420
GIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQK
Sbjct: 361 GIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQK 420
Query: 421 KKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHR 480
KKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHR
Sbjct: 421 KKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHR 480
Query: 481 YFMGYLFFLLFMICWMIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVF 540
YFMGYLFFLLFMICWMIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVF
Sbjct: 481 YFMGYLFFLLFMICWMIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVF 540
Query: 541 HFMWVAVLLMCQMYQISCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEF 600
HFMWVAVLLMCQMYQISCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEF
Sbjct: 541 HFMWVAVLLMCQMYQISCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEF 600
Query: 601 RCCGLFRPVIVDWTRQYTIEYDQISGSGYQLV 632
RCCGLFRPVIVDWTRQYTIEYDQISGSGYQLV
Sbjct: 601 RCCGLFRPVIVDWTRQYTIEYDQISGSGYQLV 632
>gi|47933346 zinc finger, DHHC domain containing 13 isoform 1 [Homo
sapiens]
Length = 622
Score = 617 bits (1592), Expect = e-177
Identities = 291/570 (51%), Positives = 396/570 (69%), Gaps = 4/570 (0%)
Query: 53 IDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISK 112
I+D S DIVKATQYGI+ERC+ELVEAGYDVRQPDKENV+LLHWAAINNR+DLVK+YISK
Sbjct: 45 IEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISK 104
Query: 113 GAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSI 172
GA+VDQLGGDLNSTPLHWA RQGHL MV+ L+++GADP+LIDGEG S IHLA F H I
Sbjct: 105 GAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPI 164
Query: 173 VAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWA 232
+AYLI+KGQ V+M D NG TPLM +A++ +PT LL FN S+N+ DK H+NT LHWA
Sbjct: 165 IAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWA 224
Query: 233 VLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFL 292
V AGN + LLEAG+++D QN+KGE+ LD+A Q KN +I+ L+ + +
Sbjct: 225 VAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHMLKTEAKMRANQKFRLW 284
Query: 293 RKLKADKEFRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDH 352
R L+ + F ++L + +W +G+I D N DSWL+KG + ++ + +
Sbjct: 285 RWLQKCELF---LLLMLSVITMWAIGYILDFNSDSWLLKGCLLVTLFFLTSLFPRFLVGY 341
Query: 353 SMHSALPLGIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGI 412
LP L++ FW+++TWF F+ DL + F+ + VA Y F K+W +DPG
Sbjct: 342 KNLVYLPTAFLLSSVFWIFMTWFILFFPDLAGAPFYFSFIFSIVAFLYFFYKTWATDPGF 401
Query: 413 IKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGN 472
KA+EE+KK I+ LAETGSLD FC++CLIRKP+RS HC VCN C+A++D HC W G
Sbjct: 402 TKASEEEKKVNIITLAETGSLDFRTFCTSCLIRKPLRSLHCHVCNCCVARYDQHCLWTGR 461
Query: 473 CVGAGNHRYFMGYLFFLLFMICWMIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMF 532
C+G GNH Y++ +LFFL + W+IYG Y HC TT+ +DG WTY+ QI CSPW+
Sbjct: 462 CIGFGNHHYYIFFLFFLSMVCGWIIYGSFIYLSSHCATTFKEDGLWTYLNQIVACSPWVL 521
Query: 533 WMFLNSVFHFMWVAVLLMCQMYQISCLGITTNERMNARRY-KHFKVTTTSIESPFNHGCV 591
++ + + FHF W LL+ Q++QI+ LG+T++ER++ ++ KH K T + ++P+N G +
Sbjct: 522 YILMLATFHFSWSTFLLLNQLFQIAFLGLTSHERISLQKQSKHMKQTLSLRKTPYNLGFM 581
Query: 592 RNIIDFFEFRCCGLFRPVIVDWTRQYTIEY 621
+N+ DFF+ C GL +P +VDWT QYT+ +
Sbjct: 582 QNLADFFQCGCFGLVKPCVVDWTSQYTMVF 611
Score = 46.2 bits (108), Expect = 9e-05
Identities = 34/128 (26%), Positives = 63/128 (49%), Gaps = 2/128 (1%)
Query: 150 PSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRL 209
P + D C + A Q+G L+ G DV D+ ++ L WAA + +D +
Sbjct: 43 PLIEDSSNCDIVK-ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAI-NNRLDLVKF 100
Query: 210 LLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRK 269
++ V+ +T LHWA+ G+ ++ LLL+ GA+ + +G S++ LA +
Sbjct: 101 YISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQ 160
Query: 270 NVWMINHL 277
++ +I +L
Sbjct: 161 HMPIIAYL 168
>gi|47933348 zinc finger, DHHC domain containing 13 isoform 2 [Homo
sapiens]
Length = 492
Score = 462 bits (1188), Expect = e-130
Identities = 217/484 (44%), Positives = 315/484 (65%), Gaps = 4/484 (0%)
Query: 139 MVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAA 198
MV+ L+++GADP+LIDGEG S IHLA F H I+AYLI+KGQ V+M D NG TPLM +A
Sbjct: 1 MVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSA 60
Query: 199 YRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKG 258
++ +PT LL FN S+N+ DK H+NT LHWAV AGN + LLEAG+++D QN+KG
Sbjct: 61 HKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKG 120
Query: 259 ESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKLKADKEFRQKVMLGTPFLVIWLVG 318
E+ LD+A Q KN +I+ L+ + + R L+ + F ++L + +W +G
Sbjct: 121 ETPLDMALQNKNQLIIHMLKTEAKMRANQKFRLWRWLQKCELF---LLLMLSVITMWAIG 177
Query: 319 FIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWF 378
+I D N DSWL+KG + ++ + + LP L++ FW+++TWF F
Sbjct: 178 YILDFNSDSWLLKGCLLVTLFFLTSLFPRFLVGYKNLVYLPTAFLLSSVFWIFMTWFILF 237
Query: 379 WNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIF 438
+ DL + F+ + VA Y F K+W +DPG KA+EE+KK I+ LAETGSLD F
Sbjct: 238 FPDLAGAPFYFSFIFSIVAFLYFFYKTWATDPGFTKASEEEKKVNIITLAETGSLDFRTF 297
Query: 439 CSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIY 498
C++CLIRKP+RS HC VCN C+A++D HC W G C+G GNH Y++ +LFFL + W+IY
Sbjct: 298 CTSCLIRKPLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIY 357
Query: 499 GCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQMYQISC 558
G Y HC TT+ +DG WTY+ QI CSPW+ ++ + + FHF W LL+ Q++QI+
Sbjct: 358 GSFIYLSSHCATTFKEDGLWTYLNQIVACSPWVLYILMLATFHFSWSTFLLLNQLFQIAF 417
Query: 559 LGITTNERMNARRY-KHFKVTTTSIESPFNHGCVRNIIDFFEFRCCGLFRPVIVDWTRQY 617
LG+T++ER++ ++ KH K T + ++P+N G ++N+ DFF+ C GL +P +VDWT QY
Sbjct: 418 LGLTSHERISLQKQSKHMKQTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCVVDWTSQY 477
Query: 618 TIEY 621
T+ +
Sbjct: 478 TMVF 481
Score = 33.9 bits (76), Expect = 0.47
Identities = 30/135 (22%), Positives = 56/135 (41%), Gaps = 34/135 (25%)
Query: 76 LVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVD------------------ 117
L++ G D D E + +H A + + ++ Y ISKG V+
Sbjct: 5 LLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVI 64
Query: 118 ---------QLGGDLN-------STPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCI 161
+ LN +TPLHWA G+++ V +L++ G+ + + +G + +
Sbjct: 65 GPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPL 124
Query: 162 HLAAQFGHTSIVAYL 176
+A Q + I+ L
Sbjct: 125 DMALQNKNQLIIHML 139
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 112 bits (279), Expect = 1e-24
Identities = 67/173 (38%), Positives = 93/173 (53%), Gaps = 4/173 (2%)
Query: 94 LHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLI 153
LH AA +D+ + GA +D D TPL A HL V L+K GA
Sbjct: 777 LHAAAEAGHVDICHMLVQAGANIDTCSED-QRTPLMEAAENNHLEAVKYLIKAGALVDPK 835
Query: 154 DGEGCSCIHLAAQFGHTSIVAYLIAKGQ-DVDMMDQNGMTPLMWAAYRTHSVDPTRLLLT 212
D EG +C+HLAA+ GH +V YL++ GQ DV+ D G TP++WA H VD +LLL+
Sbjct: 836 DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKH-VDLVKLLLS 894
Query: 213 FNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLA 265
+N+ D +N LHWA +G + +LL A ++ A NI G+S L +A
Sbjct: 895 KGSDINIRDN-EENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIA 946
Score = 99.0 bits (245), Expect = 1e-20
Identities = 69/233 (29%), Positives = 113/233 (48%), Gaps = 4/233 (1%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A + G + C LV+AG ++ ++ T L AA NN ++ VKY I GA+VD +
Sbjct: 780 AAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAE- 838
Query: 124 NSTPLHWATRQGHLSMVVQLMKYG-ADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQD 182
ST LH A ++GH +V L+ G D + D G + + A ++ H +V L++KG D
Sbjct: 839 GSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSD 898
Query: 183 VDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVIS 242
+++ D L WAA+ + VD +LL ++ H ++ LH A +
Sbjct: 899 INIRDNEENICLHWAAF-SGCVDIAEILLAAKCDLH-AVNIHGDSPLHIAARENRYDCVV 956
Query: 243 LLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKL 295
L L ++V +N +GE+ L A VW + +A Q D PS + ++
Sbjct: 957 LFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERI 1009
Score = 58.2 bits (139), Expect = 2e-08
Identities = 45/153 (29%), Positives = 77/153 (50%), Gaps = 5/153 (3%)
Query: 128 LHWATRQGHLSMVVQLMKYGADPS--LIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDM 185
L+++ RQG L V+ ++ G DP+ + S +H AA+ GH I L+ G ++D
Sbjct: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
Query: 186 MDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLL 245
++ TPLM AA H ++ + L+ V+ D +T LH A G+ V+ LL
Sbjct: 802 CSEDQRTPLMEAAENNH-LEAVKYLIKAGALVDPKDA-EGSTCLHLAAKKGHYEVVQYLL 859
Query: 246 EAG-ANVDAQNIKGESALDLAKQRKNVWMINHL 277
G +V+ Q+ G + + A + K+V ++ L
Sbjct: 860 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 892
Score = 43.9 bits (102), Expect = 5e-04
Identities = 29/106 (27%), Positives = 50/106 (47%), Gaps = 5/106 (4%)
Query: 54 DDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKG 113
DD ++ AT+Y + + L+ G D+ D E LHWAA + +D+ + ++
Sbjct: 870 DDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAK 929
Query: 114 AIVD--QLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEG 157
+ + GD +PLH A R+ VV + +D +L + EG
Sbjct: 930 CDLHAVNIHGD---SPLHIAARENRYDCVVLFLSRDSDVTLKNKEG 972
Score = 31.6 bits (70), Expect = 2.3
Identities = 20/87 (22%), Positives = 44/87 (50%), Gaps = 1/87 (1%)
Query: 195 MWAAYRTHSVDPTRLLLTFNVSVNLGDKY-HKNTALHWAVLAGNTTVISLLLEAGANVDA 253
++ + R + L+L + N ++ +K + LH A AG+ + +L++AGAN+D
Sbjct: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
Query: 254 QNIKGESALDLAKQRKNVWMINHLQEA 280
+ + L A + ++ + +L +A
Sbjct: 802 CSEDQRTPLMEAAENNHLEAVKYLIKA 828
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 101 bits (252), Expect = 2e-21
Identities = 68/210 (32%), Positives = 106/210 (50%), Gaps = 4/210 (1%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A Q G E C L++AG ++ DK+ T L A +NN +++ +Y + +G V D
Sbjct: 658 AAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEED- 716
Query: 124 NSTPLHWATRQGHLSMVVQLMKYG-ADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQD 182
ST LH A + G+L MV L+ G D + D G + I AA+ H ++ L+ +G D
Sbjct: 717 GSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGAD 776
Query: 183 VDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVIS 242
V + D L WA++ T S +LL ++ + YH +T LH A +
Sbjct: 777 VTLTDNEENICLHWASF-TGSAAIAEVLLNARCDLHAVN-YHGDTPLHIAARESYHDCVL 834
Query: 243 LLLEAGANVDAQNIKGESALDLAKQRKNVW 272
L L GAN + +N +G++A DL +R +VW
Sbjct: 835 LFLSRGANPELRNKEGDTAWDLTPERSDVW 864
Score = 79.7 bits (195), Expect = 7e-15
Identities = 51/174 (29%), Positives = 84/174 (48%), Gaps = 36/174 (20%)
Query: 126 TPLHWATRQGHLSMVVQLMKYGADPSLID------------------------------- 154
TPLH A ++G + + L++ GA+ + +D
Sbjct: 653 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 712
Query: 155 --GEGCSCIHLAAQFGHTSIVAYLIAKGQ-DVDMMDQNGMTPLMWAAYRTHSVDPTRLLL 211
+G +C+H AA+ G+ +V+ L++ GQ DV+ D G TP++WAA H ++ R+LL
Sbjct: 713 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKH-IEVIRMLL 771
Query: 212 TFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLA 265
T V L D +N LHWA G+ + +LL A ++ A N G++ L +A
Sbjct: 772 TRGADVTLTDN-EENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 824
Score = 34.7 bits (78), Expect = 0.27
Identities = 24/74 (32%), Positives = 38/74 (51%), Gaps = 7/74 (9%)
Query: 209 LLLTFNVSVNL-GDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQ 267
L+L N+ N D+ K T LH A G+ + +LL+AGAN++A + + + L
Sbjct: 634 LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPL----- 688
Query: 268 RKNVWMINHLQEAR 281
+ NHL+ AR
Sbjct: 689 -MEAVVNNHLEVAR 701
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 101 bits (252), Expect = 2e-21
Identities = 68/210 (32%), Positives = 106/210 (50%), Gaps = 4/210 (1%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A Q G E C L++AG ++ DK+ T L A +NN +++ +Y + +G V D
Sbjct: 692 AAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEED- 750
Query: 124 NSTPLHWATRQGHLSMVVQLMKYG-ADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQD 182
ST LH A + G+L MV L+ G D + D G + I AA+ H ++ L+ +G D
Sbjct: 751 GSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGAD 810
Query: 183 VDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVIS 242
V + D L WA++ T S +LL ++ + YH +T LH A +
Sbjct: 811 VTLTDNEENICLHWASF-TGSAAIAEVLLNARCDLHAVN-YHGDTPLHIAARESYHDCVL 868
Query: 243 LLLEAGANVDAQNIKGESALDLAKQRKNVW 272
L L GAN + +N +G++A DL +R +VW
Sbjct: 869 LFLSRGANPELRNKEGDTAWDLTPERSDVW 898
Score = 79.7 bits (195), Expect = 7e-15
Identities = 51/174 (29%), Positives = 84/174 (48%), Gaps = 36/174 (20%)
Query: 126 TPLHWATRQGHLSMVVQLMKYGADPSLID------------------------------- 154
TPLH A ++G + + L++ GA+ + +D
Sbjct: 687 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS 746
Query: 155 --GEGCSCIHLAAQFGHTSIVAYLIAKGQ-DVDMMDQNGMTPLMWAAYRTHSVDPTRLLL 211
+G +C+H AA+ G+ +V+ L++ GQ DV+ D G TP++WAA H ++ R+LL
Sbjct: 747 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKH-IEVIRMLL 805
Query: 212 TFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLA 265
T V L D +N LHWA G+ + +LL A ++ A N G++ L +A
Sbjct: 806 TRGADVTLTDN-EENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIA 858
Score = 34.7 bits (78), Expect = 0.27
Identities = 24/74 (32%), Positives = 38/74 (51%), Gaps = 7/74 (9%)
Query: 209 LLLTFNVSVNL-GDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQ 267
L+L N+ N D+ K T LH A G+ + +LL+AGAN++A + + + L
Sbjct: 668 LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPL----- 722
Query: 268 RKNVWMINHLQEAR 281
+ NHL+ AR
Sbjct: 723 -MEAVVNNHLEVAR 735
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 99.8 bits (247), Expect = 7e-21
Identities = 65/200 (32%), Positives = 101/200 (50%), Gaps = 12/200 (6%)
Query: 76 LVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQG 135
L+EA V D + + LH+AA R + +K + G+ V+ + D PLH A + G
Sbjct: 68 LLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVN-IPSDEGHIPLHLAAQHG 126
Query: 136 HLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV--------DMMD 187
H + L+++ ++P ++D G + + LA +FG +V L++ D D
Sbjct: 127 HYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATD 186
Query: 188 QNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEA 247
NG +PL AA H +D RLLL + +N K TALH A L G T V+ LLL++
Sbjct: 187 PNGTSPLHLAAKNGH-IDIIRLLLQAGIDINRQTK--SGTALHEAALCGKTEVVRLLLDS 243
Query: 248 GANVDAQNIKGESALDLAKQ 267
G N +N ++ALD+ Q
Sbjct: 244 GINAHVRNTYSQTALDIVHQ 263
Score = 55.8 bits (133), Expect = 1e-07
Identities = 40/125 (32%), Positives = 67/125 (53%), Gaps = 4/125 (3%)
Query: 154 DGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTF 213
D +G S +H AA G+T +++ L+ VD+ D GM PL +AA++ +P +L+L
Sbjct: 46 DPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRK-EPMKLVLKA 104
Query: 214 NVSVNL-GDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVW 272
+VN+ D+ H LH A G+ V +LL+ +N + G++ LDLA + V
Sbjct: 105 GSAVNIPSDEGH--IPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVG 162
Query: 273 MINHL 277
++ L
Sbjct: 163 VVQLL 167
>gi|197304690 zinc finger, DHHC-type containing 4 [Homo sapiens]
Length = 344
Score = 97.8 bits (242), Expect = 3e-20
Identities = 61/174 (35%), Positives = 87/174 (50%), Gaps = 16/174 (9%)
Query: 330 IKGLMYGG-----------VWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWF 378
+KGL GG + V L F H+ + L + L + TW +
Sbjct: 30 LKGLARGGAQIFSCIIPECLQRAVHGLLHYLFHTRNHTFIVLHLVLQGMVYTEYTWEVFG 89
Query: 379 WN---DLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDL 435
+ +L+ ++ LP+L V LF+ F + ++PGII E + E E
Sbjct: 90 YCQELELSLHYLLLPYLLLGVNLFF-FTLTCGTNPGIITKANELLFLHVYEFDEV-MFPK 147
Query: 436 SIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFL 489
++ CSTC +RKP RSKHC VCN C+ +FDHHC WV NC+GA N RYF+ Y+ L
Sbjct: 148 NVRCSTCDLRKPARSKHCSVCNWCVHRFDHHCVWVNNCIGAWNIRYFLIYVLTL 201
>gi|197304688 zinc finger, DHHC-type containing 4 [Homo sapiens]
Length = 344
Score = 97.8 bits (242), Expect = 3e-20
Identities = 61/174 (35%), Positives = 87/174 (50%), Gaps = 16/174 (9%)
Query: 330 IKGLMYGG-----------VWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWF 378
+KGL GG + V L F H+ + L + L + TW +
Sbjct: 30 LKGLARGGAQIFSCIIPECLQRAVHGLLHYLFHTRNHTFIVLHLVLQGMVYTEYTWEVFG 89
Query: 379 WN---DLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDL 435
+ +L+ ++ LP+L V LF+ F + ++PGII E + E E
Sbjct: 90 YCQELELSLHYLLLPYLLLGVNLFF-FTLTCGTNPGIITKANELLFLHVYEFDEV-MFPK 147
Query: 436 SIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFL 489
++ CSTC +RKP RSKHC VCN C+ +FDHHC WV NC+GA N RYF+ Y+ L
Sbjct: 148 NVRCSTCDLRKPARSKHCSVCNWCVHRFDHHCVWVNNCIGAWNIRYFLIYVLTL 201
>gi|197304686 zinc finger, DHHC-type containing 4 [Homo sapiens]
Length = 344
Score = 97.8 bits (242), Expect = 3e-20
Identities = 61/174 (35%), Positives = 87/174 (50%), Gaps = 16/174 (9%)
Query: 330 IKGLMYGG-----------VWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWF 378
+KGL GG + V L F H+ + L + L + TW +
Sbjct: 30 LKGLARGGAQIFSCIIPECLQRAVHGLLHYLFHTRNHTFIVLHLVLQGMVYTEYTWEVFG 89
Query: 379 WN---DLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDL 435
+ +L+ ++ LP+L V LF+ F + ++PGII E + E E
Sbjct: 90 YCQELELSLHYLLLPYLLLGVNLFF-FTLTCGTNPGIITKANELLFLHVYEFDEV-MFPK 147
Query: 436 SIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFL 489
++ CSTC +RKP RSKHC VCN C+ +FDHHC WV NC+GA N RYF+ Y+ L
Sbjct: 148 NVRCSTCDLRKPARSKHCSVCNWCVHRFDHHCVWVNNCIGAWNIRYFLIYVLTL 201
>gi|8922448 zinc finger, DHHC-type containing 4 [Homo sapiens]
Length = 344
Score = 97.8 bits (242), Expect = 3e-20
Identities = 61/174 (35%), Positives = 87/174 (50%), Gaps = 16/174 (9%)
Query: 330 IKGLMYGG-----------VWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWF 378
+KGL GG + V L F H+ + L + L + TW +
Sbjct: 30 LKGLARGGAQIFSCIIPECLQRAVHGLLHYLFHTRNHTFIVLHLVLQGMVYTEYTWEVFG 89
Query: 379 WN---DLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDL 435
+ +L+ ++ LP+L V LF+ F + ++PGII E + E E
Sbjct: 90 YCQELELSLHYLLLPYLLLGVNLFF-FTLTCGTNPGIITKANELLFLHVYEFDEV-MFPK 147
Query: 436 SIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFL 489
++ CSTC +RKP RSKHC VCN C+ +FDHHC WV NC+GA N RYF+ Y+ L
Sbjct: 148 NVRCSTCDLRKPARSKHCSVCNWCVHRFDHHCVWVNNCIGAWNIRYFLIYVLTL 201
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 97.1 bits (240), Expect = 5e-20
Identities = 75/249 (30%), Positives = 122/249 (48%), Gaps = 7/249 (2%)
Query: 48 GRKTHIDDYSTWD-IVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLV 106
G +++D W ++ A++ G EL++ G ++ D T L WA R D+V
Sbjct: 61 GANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVV 120
Query: 107 KYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQ 166
+ +S GA + G + P+ WA +GH +V L++ GA + D G + + AA+
Sbjct: 121 ELLLSHGAN-PSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAAR 179
Query: 167 FGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKN 226
GH V +L+A G DVD N MT L+ A + + +L N +VNL DK N
Sbjct: 180 KGHLECVKHLLAMGADVDQEGANSMTALI-VAVKGGYTQSVKEILKRNPNVNLTDK-DGN 237
Query: 227 TALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEAR---QA 283
TAL A G+T ++ LL+AG V+ + G++ L A + +V ++ L +
Sbjct: 238 TALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDI 297
Query: 284 KGYDNPSFL 292
+G DN + L
Sbjct: 298 RGQDNKTAL 306
Score = 96.3 bits (238), Expect = 8e-20
Identities = 68/222 (30%), Positives = 118/222 (53%), Gaps = 3/222 (1%)
Query: 56 YSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAI 115
YS + I+ A G + L++ G V DK T L WAA ++ VK+ ++ GA
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
Query: 116 VDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAY 175
VDQ G + + T L A + G+ V +++K + +L D +G + + +A++ GHT IV
Sbjct: 196 VDQEGAN-SMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQD 254
Query: 176 LIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLA 235
L+ G V++ D++G T L+ A H V+ R LL +++ + +K TAL+WAV
Sbjct: 255 LLDAGTYVNIPDRSGDTVLIGAVRGGH-VEIVRALLQKYADIDIRGQDNK-TALYWAVEK 312
Query: 236 GNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHL 277
GN T++ +L+ + + GE+ L A + +N+ ++ L
Sbjct: 313 GNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL 354
Score = 77.0 bits (188), Expect = 5e-14
Identities = 53/175 (30%), Positives = 91/175 (52%), Gaps = 3/175 (1%)
Query: 103 IDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIH 162
I +K + K VD+ + TPL A QG+L +V +L+K GA+ +L D + + +
Sbjct: 18 IPALKALLEKCKDVDERN-ECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 163 LAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDK 222
A++ GH IV L+ G +++ D G T LMWA Y+ + D LLL+ + ++
Sbjct: 77 SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRT-DVVELLLSHGANPSVTGL 135
Query: 223 YHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHL 277
Y + WA G+ ++ LLL+ GA V+ + G + L A ++ ++ + HL
Sbjct: 136 YSVYPII-WAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHL 189
Score = 65.1 bits (157), Expect = 2e-10
Identities = 39/131 (29%), Positives = 70/131 (53%), Gaps = 1/131 (0%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A++ G E ++L++AG V PD+ T+L A +++V+ + K A +D G D
Sbjct: 243 ASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQD- 301
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 183
N T L+WA +G+ +MV +++ D + +G + + A + + +V L+ KG V
Sbjct: 302 NKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKV 361
Query: 184 DMMDQNGMTPL 194
+D+ G TPL
Sbjct: 362 SAVDKKGDTPL 372
>gi|37594451 Abl-philin 2 isoform 2 [Homo sapiens]
Length = 361
Score = 94.7 bits (234), Expect = 2e-19
Identities = 55/168 (32%), Positives = 80/168 (47%), Gaps = 24/168 (14%)
Query: 439 CSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIY 498
C C+ KP R+ HC +CNRC+ K DHHCPW+ NCVG NHRYF + FF+ + Y
Sbjct: 157 CKKCIYPKPARTHHCSICNRCVLKMDHHCPWLNNCVGHYNHRYFFSFCFFMTLGCVYCSY 216
Query: 499 GCISYWGLHCET-----TY--TKDGFWTYITQIATCSPWMFWMFLNSVFHFM-----WVA 546
G W L E TY T +++ ++ S W +SV + W A
Sbjct: 217 GS---WDLFREAYAAIETYHQTPPPTFSFRERMTHKSLVYLWFLCSSVALALGALTVWHA 273
Query: 547 VLLMCQMYQISCLGITTNER-MNARRYKHFKVTTTSIESPFNHGCVRN 593
VL+ G T+ ER +N + + + +P+N+GC+ N
Sbjct: 274 VLI--------SRGETSIERHINKKERRRLQAKGRVFRNPYNYGCLDN 313
>gi|37594447 Abl-philin 2 isoform 4 [Homo sapiens]
Length = 296
Score = 94.7 bits (234), Expect = 2e-19
Identities = 55/168 (32%), Positives = 80/168 (47%), Gaps = 24/168 (14%)
Query: 439 CSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIY 498
C C+ KP R+ HC +CNRC+ K DHHCPW+ NCVG NHRYF + FF+ + Y
Sbjct: 92 CKKCIYPKPARTHHCSICNRCVLKMDHHCPWLNNCVGHYNHRYFFSFCFFMTLGCVYCSY 151
Query: 499 GCISYWGLHCET-----TY--TKDGFWTYITQIATCSPWMFWMFLNSVFHFM-----WVA 546
G W L E TY T +++ ++ S W +SV + W A
Sbjct: 152 GS---WDLFREAYAAIETYHQTPPPTFSFRERMTHKSLVYLWFLCSSVALALGALTVWHA 208
Query: 547 VLLMCQMYQISCLGITTNER-MNARRYKHFKVTTTSIESPFNHGCVRN 593
VL+ G T+ ER +N + + + +P+N+GC+ N
Sbjct: 209 VLI--------SRGETSIERHINKKERRRLQAKGRVFRNPYNYGCLDN 248
>gi|41152072 zinc finger, DHHC domain containing 5 [Homo sapiens]
Length = 715
Score = 94.4 bits (233), Expect = 3e-19
Identities = 67/234 (28%), Positives = 104/234 (44%), Gaps = 43/234 (18%)
Query: 370 MYVTWFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKT------ 423
+YV+ +N + FLF+ NF + DPGI EE + K
Sbjct: 41 LYVSPAVPIYNAIMFLFV-----------LANFSMATFMDPGIFPRAEEDEDKEDDFRAP 89
Query: 424 IVELAETGSLDLSI-FCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYF 482
+ + E + + + +C+TC +P R HC VC+ C+ +FDHHCPWV NC+G N+RYF
Sbjct: 90 LYKTVEIKGIQVRMKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNNCIGRRNYRYF 149
Query: 483 MGYLFFLLFMICWMIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSV--F 540
+L L I + + Y H E G T +T C +F++ + + F
Sbjct: 150 FLFLLSLTAHIMGVFGFGLLYVLYHIEEL---SGVRTAVTMAVMCVAGLFFIPVAGLTGF 206
Query: 541 HFMWVAVLLMCQMYQISCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNI 594
H + VA G TTNE++ + F+ +PF +GC N+
Sbjct: 207 HVVLVA------------RGRTTNEQVTGK----FRGGV----NPFTNGCCNNV 240
>gi|30348954 mindbomb homolog 1 [Homo sapiens]
Length = 1006
Score = 93.2 bits (230), Expect = 7e-19
Identities = 76/232 (32%), Positives = 114/232 (49%), Gaps = 29/232 (12%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQL---G 120
A+Q G + + L++ DV DK+ +H AA + +GA+++ L
Sbjct: 471 ASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGD----------EGAVIEVLHRGS 520
Query: 121 GDLNS------TPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVA 174
DLN+ TPLH A +GHL +V L+ +G PSL D EG + +H A I+A
Sbjct: 521 ADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILA 580
Query: 175 YLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLT-----FNVSVNLGDKYHKNTAL 229
L+ G DV + + NG L AA R + R+LL+ + V D Y TAL
Sbjct: 581 VLLEAGADVTITNNNGFNALHHAALRGNP-SAMRVLLSKLPRPWIVDEKKDDGY---TAL 636
Query: 230 HWAVLAGNTTVISLLLEAG-ANVDAQNIKGESALDLAKQRKNVWMINHLQEA 280
H A L + V LL+ G AN+D QN+ ++AL LA +R++ ++ L A
Sbjct: 637 HLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRA 688
Score = 63.5 bits (153), Expect = 6e-10
Identities = 59/200 (29%), Positives = 91/200 (45%), Gaps = 13/200 (6%)
Query: 76 LVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGA---IVDQLGGDLNSTPLHWAT 132
L+EAG DV + LH AA+ ++ +SK IVD+ D T LH A
Sbjct: 582 LLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDD-GYTALHLAA 640
Query: 133 RQGHLSMVVQLMKYG-ADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGM 191
H+ + L+ G A+ + + + +HLA + HT IV L+ G +D+ D++G
Sbjct: 641 LNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGD 700
Query: 192 TPLMWAAYRTHSVDPTRLLLTFNV--SVNLGDKYHKNTAL-----HWAVLAGNTTVISLL 244
TPL A R H++ R L V+ + KNT + A ++ L
Sbjct: 701 TPLH-EALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFL 759
Query: 245 LEAGANVDAQNIKGESALDL 264
GA++ +N KG+S LDL
Sbjct: 760 AANGADLSIRNKKGQSPLDL 779
Score = 63.2 bits (152), Expect = 7e-10
Identities = 58/201 (28%), Positives = 97/201 (48%), Gaps = 6/201 (2%)
Query: 71 ERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHW 130
ER +L++ ++ ++ N L+ AA N + V+ + K VD G T +
Sbjct: 413 ERLSQLLKKLFETQESGDLNEELVK-AAANGDVAKVEDLL-KRPDVDVNGQCAGHTAMQA 470
Query: 131 ATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQ-DVDMMDQN 189
A++ GH+ ++ L+K D D +G +H AA FG V ++ +G D++ ++
Sbjct: 471 ASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAA-FGDEGAVIEVLHRGSADLNARNKR 529
Query: 190 GMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGA 249
TPL A + H + + LL F +L D +T LH A+ ++++LLEAGA
Sbjct: 530 RQTPLHIAVNKGH-LQVVKTLLDFGCHPSLQDS-EGDTPLHDAISKKRDDILAVLLEAGA 587
Query: 250 NVDAQNIKGESALDLAKQRKN 270
+V N G +AL A R N
Sbjct: 588 DVTITNNNGFNALHHAALRGN 608
>gi|21361910 zinc finger, DHHC domain containing 12 [Homo sapiens]
Length = 267
Score = 92.8 bits (229), Expect = 8e-19
Identities = 61/223 (27%), Positives = 107/223 (47%), Gaps = 20/223 (8%)
Query: 379 WNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSI- 437
W + L + L FL + + DPG + + +++ E +T + +I
Sbjct: 38 WEEQGELLLPLTFLLLVLGSLLLYLAVSLMDPGYVNVQPQPQEELKEE--QTAMVPPAIP 95
Query: 438 --FCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICW 495
C CL+ +P+R++HC C RC+ ++DHHCPW+ NCVG NH F+ YL L ++ W
Sbjct: 96 LRRCRYCLVLQPLRARHCRECRRCVRRYDHHCPWMENCVGERNHPLFVVYLALQLVVLLW 155
Query: 496 MIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQMYQ 555
+Y +++ GL + G W S +F FL + ++LL+ +Y
Sbjct: 156 GLY--LAWSGLR---FFQPWGLW------LRSSGLLFATFLLLSLFSLVASLLLVSHLYL 204
Query: 556 ISCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFF 598
++ TT E +++ R + + + +PF+ G RN+ FF
Sbjct: 205 VAS-NTTTWEFISSHRIAYLRQRPS---NPFDRGLTRNLAHFF 243
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 92.4 bits (228), Expect = 1e-18
Identities = 66/214 (30%), Positives = 104/214 (48%), Gaps = 8/214 (3%)
Query: 68 GIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIV---DQLGGDLN 124
G E L+ G ++ DK++ LHWAA +D+V I+ GA V D+ G
Sbjct: 126 GHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG---- 181
Query: 125 STPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVD 184
TPLH A G +++V L+ G + I+ G + +H+A G ++V LI G +V+
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241
Query: 185 MMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLL 244
+ NG TPL +AA TH LL+ VN+ K K + LH + G T L
Sbjct: 242 QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGK-SPLHMTAVHGRFTRSQTL 300
Query: 245 LEAGANVDAQNIKGESALDLAKQRKNVWMINHLQ 278
++ G +D + G + L +A + + +IN L+
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLR 334
Score = 87.4 bits (215), Expect = 4e-17
Identities = 67/197 (34%), Positives = 93/197 (47%), Gaps = 7/197 (3%)
Query: 71 ERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYIS--KGAIVDQLGGDLNSTPL 128
E + L++ DV DK T LH AA N + + I V GG T L
Sbjct: 63 EAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGG---RTAL 119
Query: 129 HWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQ 188
H A GH+ MV L+ GA+ + D + +H AA GH +VA LI G +V D+
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
Query: 189 NGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAG 248
G TPL AA ++ + LL V ++ + Y NTALH A G V++ L++ G
Sbjct: 180 KGYTPL-HAAASNGQINVVKHLLNLGVEIDEINVY-GNTALHIACYNGQDAVVNELIDYG 237
Query: 249 ANVDAQNIKGESALDLA 265
ANV+ N G + L A
Sbjct: 238 ANVNQPNNNGFTPLHFA 254
Score = 83.6 bits (205), Expect = 5e-16
Identities = 59/192 (30%), Positives = 95/192 (49%), Gaps = 4/192 (2%)
Query: 75 ELVEAGYDVRQPDKENVTLLHWAAINNRIDL-VKYYISKGAIVDQLGGDLNSTPLHWATR 133
EL++ G +V QP+ T LH+AA + L ++ ++ GA V+ D +PLH
Sbjct: 232 ELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKD-GKSPLHMTAV 290
Query: 134 QGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTP 193
G + L++ G + +D +G + +H+AA++GH ++ L G D + M P
Sbjct: 291 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP 350
Query: 194 LMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDA 253
L AA HS D R LL+ ++ DK+ + T LH A GN I LL +GA+
Sbjct: 351 LHLAALNAHS-DCCRKLLSSGFEIDTPDKFGR-TCLHAAAAGGNVECIKLLQSSGADFHK 408
Query: 254 QNIKGESALDLA 265
++ G + L A
Sbjct: 409 KDKCGRTPLHYA 420
Score = 73.2 bits (178), Expect = 7e-13
Identities = 60/190 (31%), Positives = 89/190 (46%), Gaps = 3/190 (1%)
Query: 76 LVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQG 135
LV G DV K+ + LH A++ R + I G +D + D N TPLH A R G
Sbjct: 267 LVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN-TPLHVAARYG 325
Query: 136 HLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLM 195
H ++ L GAD + +HLAA H+ L++ G ++D D+ G T L
Sbjct: 326 HELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLH 385
Query: 196 WAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQN 255
AA +V+ +LL + + DK + T LH+A + I L+ GANV+ +
Sbjct: 386 -AAAAGGNVECIKLLQSSGADFHKKDKCGR-TPLHYAAANCHFHCIETLVTTGANVNETD 443
Query: 256 IKGESALDLA 265
G +AL A
Sbjct: 444 DWGRTALHYA 453
Score = 68.6 bits (166), Expect = 2e-11
Identities = 66/264 (25%), Positives = 110/264 (41%), Gaps = 68/264 (25%)
Query: 68 GIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTP 127
G E + L +G D + DK T LH+AA N ++ ++ GA V++ D T
Sbjct: 391 GNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETD-DWGRTA 449
Query: 128 LHWAT---------------------------RQGHLSMVVQ-LMKYGADPSLIDGEGCS 159
LH+A ++ ++ ++ L++ A+PS+ D EG +
Sbjct: 450 LHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYN 509
Query: 160 CIHLAAQFGHTSIVAYLIAKGQ-----------------------------------DVD 184
IH AA +GH + L+ + D+D
Sbjct: 510 SIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLD 569
Query: 185 MMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLL 244
+ D+ G T L AA++ H+ + L+ S+ + D K T LH +V+ G+T + LL
Sbjct: 570 IRDEKGRTALDLAAFKGHT-ECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLL 628
Query: 245 LEAGAN---VDAQNIKGESALDLA 265
LE N VD ++ KG++ L LA
Sbjct: 629 LEIADNPEAVDVKDAKGQTPLMLA 652
Score = 63.9 bits (154), Expect = 4e-10
Identities = 54/167 (32%), Positives = 80/167 (47%), Gaps = 8/167 (4%)
Query: 126 TPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDM 185
TPLH A G ++ L+ GA + D + +H A V LI DV+
Sbjct: 18 TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77
Query: 186 MDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLL 245
D+N TPL AA +V +++ SVN+ D+ + TALH A L G+ +++LLL
Sbjct: 78 RDKNWQTPLHVAA-ANKAVKCAEVIIPLLSSVNVSDRGGR-TALHHAALNGHVEMVNLLL 135
Query: 246 EAGANVDAQNIKGESALDLAKQRKNV----WMINHLQE--ARQAKGY 286
GAN++A + K AL A ++ +INH E + KGY
Sbjct: 136 AKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGY 182
Score = 63.2 bits (152), Expect = 7e-10
Identities = 50/166 (30%), Positives = 77/166 (46%), Gaps = 3/166 (1%)
Query: 67 YGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNST 126
+G + R + L++ G ++ DK+ T LH AA L+ + GA + G +
Sbjct: 291 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIH-SMF 349
Query: 127 PLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMM 186
PLH A H +L+ G + D G +C+H AA G+ + L + G D
Sbjct: 350 PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409
Query: 187 DQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWA 232
D+ G TPL +AA H L+T +VN D + + TALH+A
Sbjct: 410 DKCGRTPLHYAAANCH-FHCIETLVTTGANVNETDDWGR-TALHYA 453
Score = 62.4 bits (150), Expect = 1e-09
Identities = 51/186 (27%), Positives = 85/186 (45%), Gaps = 5/186 (2%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A G ++ L+++ D+ D++ T L AA + V+ I+ GA +
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLI---DGEGCSCIHLAAQFGHTSIVAYLIAKG 180
TPLH + GH + L++ +P + D +G + + LA +GH V+ L+ K
Sbjct: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668
Query: 181 QDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTV 240
+VD +D G T L H + ++LL VS+ D T LH+A G+ T
Sbjct: 669 ANVDTVDILGCTALHRGIMTGHE-ECVQMLLEQEVSILCKDS-RGRTPLHYAAARGHATW 726
Query: 241 ISLLLE 246
+S LL+
Sbjct: 727 LSELLQ 732
Score = 61.6 bits (148), Expect = 2e-09
Identities = 41/125 (32%), Positives = 60/125 (48%), Gaps = 7/125 (5%)
Query: 126 TPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDM 185
TPL A GH+ V L++ A+ +D GC+ +H GH V L+ + +
Sbjct: 647 TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILC 706
Query: 186 MDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKN----TALHWAVLAGNTTVI 241
D G TPL +AA R H+ + LL ++++ D K+ T LHWA GN I
Sbjct: 707 KDSRGRTPLHYAAARGHATWLSELL---QMALSEEDCCFKDNQGYTPLHWACYNGNENCI 763
Query: 242 SLLLE 246
+LLE
Sbjct: 764 EVLLE 768
Score = 59.3 bits (142), Expect = 1e-08
Identities = 58/233 (24%), Positives = 93/233 (39%), Gaps = 41/233 (17%)
Query: 87 DKENVTLLHWAAINNRIDLVKYYISK-GAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMK 145
DKE +H+AA ++ + + + ++ +PLH A GH + L++
Sbjct: 504 DKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQ 563
Query: 146 YGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKG------------------------- 180
D + D +G + + LAA GHT V LI G
Sbjct: 564 SLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTL 623
Query: 181 ------------QDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTA 228
+ VD+ D G TPLM A H +D LLL +V+ D TA
Sbjct: 624 CLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGH-IDAVSLLLEKEANVDTVDILGC-TA 681
Query: 229 LHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKN-VWMINHLQEA 280
LH ++ G+ + +LLE ++ ++ +G + L A R + W+ LQ A
Sbjct: 682 LHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMA 734
Score = 46.2 bits (108), Expect = 9e-05
Identities = 39/135 (28%), Positives = 58/135 (42%), Gaps = 1/135 (0%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A +YG L +G D + ++ LH AA+N D + +S G +D
Sbjct: 321 AARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDT-PDKF 379
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 183
T LH A G++ + L GAD D G + +H AA H + L+ G +V
Sbjct: 380 GRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANV 439
Query: 184 DMMDQNGMTPLMWAA 198
+ D G T L +AA
Sbjct: 440 NETDDWGRTALHYAA 454
Score = 44.3 bits (103), Expect = 3e-04
Identities = 48/183 (26%), Positives = 74/183 (40%), Gaps = 8/183 (4%)
Query: 70 YERCRE-LVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNS--T 126
+E C + L+E + D T LH+AA + + + N T
Sbjct: 690 HEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYT 749
Query: 127 PLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAK--GQDVD 184
PLHWA G+ + + L++ I G + +H A H + + L+ V
Sbjct: 750 PLHWACYNGNENCIEVLLEQKCFRKFI-GNPFTPLHCAIINDHGNCASLLLGAIDSSIVS 808
Query: 185 MMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLL 244
D G TPL AA+ H V+ +LLL + VN D K TAL A G + +L
Sbjct: 809 CRDDKGRTPLRAAAFADH-VECLQLLLRHSAPVNAVDNSGK-TALMMAAENGQAGAVDIL 866
Query: 245 LEA 247
+ +
Sbjct: 867 VNS 869
Score = 37.7 bits (86), Expect = 0.032
Identities = 29/96 (30%), Positives = 48/96 (50%), Gaps = 2/96 (2%)
Query: 176 LIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLA 235
LI K +DV+ +D TPL AA+ + LL+ VN D T LH AV +
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAF-LGDAEIIELLILSGARVNAKDNMWL-TPLHRAVAS 59
Query: 236 GNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNV 271
+ + +L++ A+V+A++ ++ L +A K V
Sbjct: 60 RSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAV 95
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 91.3 bits (225), Expect = 2e-18
Identities = 80/242 (33%), Positives = 110/242 (45%), Gaps = 12/242 (4%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A Q R LV D + E T LH AA + LVK S+GA +D +L
Sbjct: 468 AAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNL 527
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 183
TPLH A +G + + L+K GA P +D G +H AA G I L+ G +
Sbjct: 528 R-TPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASL 586
Query: 184 DMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKN-TALHWAVLAGNTTVIS 242
++ G TPL AAY+ H ++ LL + N+G N T LH A G V+S
Sbjct: 587 ELPTHQGWTPLHLAAYKGH-LEIIHLLAESHA--NMGALGAVNWTPLHLAARHGEEAVVS 643
Query: 243 LLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQE------ARQAKGYDNPSFLRKLK 296
LL+ GA+ +A G + L LA QR + +L E AR G+ P+ L LK
Sbjct: 644 ALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGW-TPAHLAALK 702
Query: 297 AD 298
+
Sbjct: 703 GN 704
Score = 82.0 bits (201), Expect = 1e-15
Identities = 63/213 (29%), Positives = 101/213 (47%), Gaps = 3/213 (1%)
Query: 73 CRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWAT 132
C L+ G D + D++ LH+AA N + + GA VD + TPLH A
Sbjct: 411 CALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAA 469
Query: 133 RQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMT 192
+ ++ L+ ADP+L + EG + +H+AA FGH S+V L ++G ++D +N T
Sbjct: 470 QNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRT 529
Query: 193 PLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVD 252
PL A R LL + V L + LH A G + +LL GA+++
Sbjct: 530 PLHLAVERGKVRAIQHLLKSGAVPDALDQSGY--GPLHTAAARGKYLICKMLLRYGASLE 587
Query: 253 AQNIKGESALDLAKQRKNVWMINHLQEARQAKG 285
+G + L LA + ++ +I+ L E+ G
Sbjct: 588 LPTHQGWTPLHLAAYKGHLEIIHLLAESHANMG 620
Score = 79.7 bits (195), Expect = 7e-15
Identities = 61/215 (28%), Positives = 107/215 (49%), Gaps = 3/215 (1%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A + G + L+++G D+ LH AA + + K + GA ++ L
Sbjct: 534 AVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLE-LPTHQ 592
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 183
TPLH A +GHL ++ L + A+ + + +HLAA+ G ++V+ L+ G D
Sbjct: 593 GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADP 652
Query: 184 DMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISL 243
+ +Q+G TPL A R+ + LL + +V+ +K T H A L GNT ++ +
Sbjct: 653 NAAEQSGWTPLHLAVQRSTFLSVIN-LLEHHANVHARNKVGW-TPAHLAALKGNTAILKV 710
Query: 244 LLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQ 278
L+EAGA +D Q+ + L LA + + +++ L+
Sbjct: 711 LVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLE 745
Score = 66.6 bits (161), Expect = 7e-11
Identities = 54/185 (29%), Positives = 79/185 (42%), Gaps = 35/185 (18%)
Query: 126 TPLHWATRQGHLSMV---------------------------------VQLMKYGADPSL 152
TPLH+ QG + V L+ +GAD +
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 153 IDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLT 212
+D +G + +H AAQ G L+ G VD ++ G TPL AA + + + RLL++
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAA-QNNFENVARLLVS 482
Query: 213 FNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVW 272
NL + K T LH A G+ +++ LL GA +DAQ + L LA +R V
Sbjct: 483 RQADPNLHEAEGK-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
Query: 273 MINHL 277
I HL
Sbjct: 542 AIQHL 546
>gi|37594449 Abl-philin 2 isoform 1 [Homo sapiens]
Length = 377
Score = 90.9 bits (224), Expect = 3e-18
Identities = 46/173 (26%), Positives = 73/173 (42%), Gaps = 18/173 (10%)
Query: 439 CSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIY 498
C C+ KP R+ HC +CNRC+ K DHHCPW+ NCVG NHRYF + FF+ + Y
Sbjct: 157 CKKCIYPKPARTHHCSICNRCVLKMDHHCPWLNNCVGHYNHRYFFSFCFFMTLGCVYCSY 216
Query: 499 GC-----ISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQM 553
G +Y + K+ Q +P + F + H V + +C
Sbjct: 217 GSWDLFREAYAAIEKMKQLDKNKLQAVANQTYHQTPPPTFSFRERMTHKSLVYLWFLCSS 276
Query: 554 YQISCLGITT-------------NERMNARRYKHFKVTTTSIESPFNHGCVRN 593
++ +T +N + + + +P+N+GC+ N
Sbjct: 277 VALALGALTVWHAVLISRGETSIERHINKKERRRLQAKGRVFRNPYNYGCLDN 329
>gi|37594455 Abl-philin 2 isoform 1 [Homo sapiens]
Length = 377
Score = 90.9 bits (224), Expect = 3e-18
Identities = 46/173 (26%), Positives = 73/173 (42%), Gaps = 18/173 (10%)
Query: 439 CSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIY 498
C C+ KP R+ HC +CNRC+ K DHHCPW+ NCVG NHRYF + FF+ + Y
Sbjct: 157 CKKCIYPKPARTHHCSICNRCVLKMDHHCPWLNNCVGHYNHRYFFSFCFFMTLGCVYCSY 216
Query: 499 GC-----ISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQM 553
G +Y + K+ Q +P + F + H V + +C
Sbjct: 217 GSWDLFREAYAAIEKMKQLDKNKLQAVANQTYHQTPPPTFSFRERMTHKSLVYLWFLCSS 276
Query: 554 YQISCLGITT-------------NERMNARRYKHFKVTTTSIESPFNHGCVRN 593
++ +T +N + + + +P+N+GC+ N
Sbjct: 277 VALALGALTVWHAVLISRGETSIERHINKKERRRLQAKGRVFRNPYNYGCLDN 329
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 90.1 bits (222), Expect = 6e-18
Identities = 66/192 (34%), Positives = 98/192 (51%), Gaps = 3/192 (1%)
Query: 74 RELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATR 133
R L++ G V Q D TLL AA + +D+V +S+GA ++ + TPL A R
Sbjct: 529 RTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLE-IEDAHGHTPLTLAAR 587
Query: 134 QGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTP 193
QGH +V L+ GA+ + D +G + + AA GHT +V+ L+ G VD D + T
Sbjct: 588 QGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTA 647
Query: 194 LMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDA 253
L AA+ H D LL VN D TAL A G+ ++ LL+ GA V+
Sbjct: 648 LRAAAWGGHE-DIVLNLLQHGAEVNKADN-EGRTALIAAAYMGHREIVEHLLDHGAEVNH 705
Query: 254 QNIKGESALDLA 265
+++ G +AL +A
Sbjct: 706 EDVDGRTALSVA 717
Score = 84.3 bits (207), Expect = 3e-16
Identities = 66/208 (31%), Positives = 101/208 (48%), Gaps = 8/208 (3%)
Query: 47 LGRKTHIDDYSTWDIVKATQYGIYERCRELVEA----GYDVRQPDKENVTLLHWAAINNR 102
L K++ID +D A + E R++VE G DV D + L+ A+ N+
Sbjct: 900 LENKSNIDQRG-YDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQ 958
Query: 103 IDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIH 162
+ + +Y++ GA V+ + T LH + QGH+ MV L+ Y AD + D E S +
Sbjct: 959 LTMAEYFLENGANVEASDAE-GRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ 1017
Query: 163 LAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDK 222
AA GH +V LI G VD G T L AA H +D ++LL N D+
Sbjct: 1018 SAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGH-IDVVQVLLEHGADPNHADQ 1076
Query: 223 YHKNTALHWAVLAGNTTVISLLLEAGAN 250
+ + TA+ A G++ +I LL + GA+
Sbjct: 1077 FGR-TAMRVAAKNGHSQIIKLLEKYGAS 1103
Score = 78.2 bits (191), Expect = 2e-14
Identities = 59/193 (30%), Positives = 92/193 (47%), Gaps = 9/193 (4%)
Query: 76 LVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQG 135
L++ G +V DK+ +T L AA +D+V + GA VD + TPL A G
Sbjct: 734 LIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNN-GRTPLLAAASMG 792
Query: 136 HLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLM 195
H S+V L+ +GA ID EG + + +A+ G+ +V L+ +G D + D G TPL
Sbjct: 793 HASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLH 852
Query: 196 WAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLA---GNTTVISLLLEAGANVD 252
AA+ H RL+ + N +LA G+ + +LLE +N+D
Sbjct: 853 MAAFEGH-----RLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNID 907
Query: 253 AQNIKGESALDLA 265
+ G +AL +A
Sbjct: 908 QRGYDGRNALRVA 920
Score = 78.2 bits (191), Expect = 2e-14
Identities = 63/226 (27%), Positives = 102/226 (45%), Gaps = 3/226 (1%)
Query: 52 HIDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYIS 111
H D+ ++ A G L+ G V D E T+L A+ +++V+ +
Sbjct: 776 HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLD 835
Query: 112 KGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTS 171
+G + + D TPLH A +GH + L++ GA + ID +G LA+Q GH
Sbjct: 836 RG-LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYD 894
Query: 172 IVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHW 231
V L+ ++D +G L AA H D LL + VN D + T L+
Sbjct: 895 CVQILLENKSNIDQRGYDGRNALRVAALEGHR-DIVELLFSHGADVNCKDADGRPT-LYI 952
Query: 232 AVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHL 277
L T+ LE GANV+A + +G +AL ++ + ++ M+ L
Sbjct: 953 LALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
Score = 76.3 bits (186), Expect = 8e-14
Identities = 62/206 (30%), Positives = 96/206 (46%), Gaps = 6/206 (2%)
Query: 76 LVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQG 135
L+ G ++ D++ T L AA ++V + G VD D + T L A G
Sbjct: 597 LIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADAD-SRTALRAAAWGG 655
Query: 136 HLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLM 195
H +V+ L+++GA+ + D EG + + AA GH IV +L+ G +V+ D +G T L
Sbjct: 656 HEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALS 715
Query: 196 WAAYRTHS----VDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANV 251
AA + LL+ V+ DK T L A G+ V+ LLLE GA+V
Sbjct: 716 VAALCVPASKGHASVVSLLIDRGAEVDHCDK-DGMTPLLVAAYEGHVDVVDLLLEGGADV 774
Query: 252 DAQNIKGESALDLAKQRKNVWMINHL 277
D + G + L A + ++N L
Sbjct: 775 DHTDNNGRTPLLAAASMGHASVVNTL 800
Score = 76.3 bits (186), Expect = 8e-14
Identities = 66/223 (29%), Positives = 105/223 (47%), Gaps = 7/223 (3%)
Query: 48 GRKTHIDDYSTWDIVKATQYGIYERC-RELVEAGYDVRQPDKENVTLLHWAAINNRIDLV 106
G K D + ++A +G +E L++ G +V + D E T L AA ++V
Sbjct: 634 GVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIV 693
Query: 107 KYYISKGAIVDQLGGD----LNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIH 162
++ + GA V+ D L+ L +GH S+V L+ GA+ D +G + +
Sbjct: 694 EHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLL 753
Query: 163 LAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDK 222
+AA GH +V L+ G DVD D NG TPL+ AA H+ LL + +V+ D
Sbjct: 754 VAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHA-SVVNTLLFWGAAVDSIDS 812
Query: 223 YHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLA 265
T L A GN V+ LL+ G + + ++ G + L +A
Sbjct: 813 -EGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMA 854
Score = 70.9 bits (172), Expect = 3e-12
Identities = 74/276 (26%), Positives = 123/276 (44%), Gaps = 5/276 (1%)
Query: 5 EGFNTKMADGPDE-YDTEAGCVPLLHPEEIKPQSHYNHGYGEPLGRKTHIDDYSTWDIVK 63
E T + G DE + +AG PL H + E R ID+ +
Sbjct: 828 EVVRTLLDRGLDENHRDDAGWTPL-HMAAFEGHRLICEALIEQGARTNEIDNDGRIPFIL 886
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A+Q G Y+ + L+E ++ Q + L AA+ D+V+ S GA V+ D
Sbjct: 887 ASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADG 946
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 183
T L+ + L+M ++ GA+ D EG + +H++ GH +V LIA DV
Sbjct: 947 RPT-LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADV 1005
Query: 184 DMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISL 243
+ D + L AA++ H V +LL+ V+ TAL A G+ V+ +
Sbjct: 1006 NAADNEKRSALQSAAWQGH-VKVVQLLIEHGAVVDHTCNQGA-TALCIAAQEGHIDVVQV 1063
Query: 244 LLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQE 279
LLE GA+ + + G +A+ +A + + +I L++
Sbjct: 1064 LLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEK 1099
Score = 65.5 bits (158), Expect = 1e-10
Identities = 56/216 (25%), Positives = 99/216 (45%), Gaps = 3/216 (1%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A+ G E R L++ G D D T LH AA + + I +GA +++ D
Sbjct: 821 ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDND- 879
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 183
P A+++GH V L++ ++ +G + + +AA GH IV L + G DV
Sbjct: 880 GRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADV 939
Query: 184 DMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISL 243
+ D +G P ++ + + L +V D + TALH + G+ ++ +
Sbjct: 940 NCKDADGR-PTLYILALENQLTMAEYFLENGANVEASDAEGR-TALHVSCWQGHMEMVQV 997
Query: 244 LLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQE 279
L+ A+V+A + + SAL A + +V ++ L E
Sbjct: 998 LIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIE 1033
>gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1363
Score = 88.6 bits (218), Expect = 2e-17
Identities = 76/277 (27%), Positives = 135/277 (48%), Gaps = 24/277 (8%)
Query: 45 EPLGRKTHIDDYSTWDIVKATQYGI---YERCRELVEAGYDVRQPDKENVTLLHWAAINN 101
E GR HI D+ I +A G E C DVR DK++ T+LH A +
Sbjct: 121 EYAGRGYHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLDVR--DKKDRTVLHLACAHG 178
Query: 102 RIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCI 161
R+ +V + + ++ + LN TPL A + + L+K GA+P++ D G + +
Sbjct: 179 RVQVVTLLLDRKCQIN-ICDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTAL 237
Query: 162 HLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWA--AYRTHSVDPTRLLLTFNVSVNL 219
H A TS+ L++ +++ +++ G TPL++A + R H V+ LL +++
Sbjct: 238 HYAVYNEGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVE---FLLKNQANIHA 294
Query: 220 GDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLA------------KQ 267
D + K TAL AV +++++LLL+ ++ +Q++ G++A D A +
Sbjct: 295 VDNF-KRTALILAVQHNLSSIVTLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILE 353
Query: 268 RKNVWMINHLQEARQAKGYDNPSFLRKLKADKEFRQK 304
KN + NHL+ Q P L+K K K+ +++
Sbjct: 354 HKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKR 390
>gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1366
Score = 88.6 bits (218), Expect = 2e-17
Identities = 76/277 (27%), Positives = 135/277 (48%), Gaps = 24/277 (8%)
Query: 45 EPLGRKTHIDDYSTWDIVKATQYGI---YERCRELVEAGYDVRQPDKENVTLLHWAAINN 101
E GR HI D+ I +A G E C DVR DK++ T+LH A +
Sbjct: 150 EYAGRGYHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLDVR--DKKDRTVLHLACAHG 207
Query: 102 RIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCI 161
R+ +V + + ++ + LN TPL A + + L+K GA+P++ D G + +
Sbjct: 208 RVQVVTLLLDRKCQIN-ICDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTAL 266
Query: 162 HLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWA--AYRTHSVDPTRLLLTFNVSVNL 219
H A TS+ L++ +++ +++ G TPL++A + R H V+ LL +++
Sbjct: 267 HYAVYNEGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVE---FLLKNQANIHA 323
Query: 220 GDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLA------------KQ 267
D + K TAL AV +++++LLL+ ++ +Q++ G++A D A +
Sbjct: 324 VDNF-KRTALILAVQHNLSSIVTLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILE 382
Query: 268 RKNVWMINHLQEARQAKGYDNPSFLRKLKADKEFRQK 304
KN + NHL+ Q P L+K K K+ +++
Sbjct: 383 HKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKR 419
>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
Length = 1202
Score = 88.2 bits (217), Expect = 2e-17
Identities = 72/243 (29%), Positives = 114/243 (46%), Gaps = 19/243 (7%)
Query: 68 GIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTP 127
G E L+EA V D + LH+AA R++ V+ + A V+ D P
Sbjct: 60 GSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLD-GQIP 118
Query: 128 LHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLI--------AK 179
LH A + GH + L+++ ++P L++ + + LA +FG + L+ +
Sbjct: 119 LHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLE 178
Query: 180 GQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTT 239
G+ D D N TPL AA H + R LL + +N K TALH A L G T
Sbjct: 179 GEAKDPCDPNYTTPLHLAAKNGHR-EVIRQLLRAGIEINRQTK--TGTALHEAALYGKTE 235
Query: 240 VISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQE-ARQAKGYDNPSFLRKLKAD 298
V+ LLLE G +V+ +N ++ALD+ Q +++ R+A G + K++A
Sbjct: 236 VVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASG------ILKVRAL 289
Query: 299 KEF 301
K+F
Sbjct: 290 KDF 292
Score = 57.4 bits (137), Expect = 4e-08
Identities = 39/112 (34%), Positives = 58/112 (51%), Gaps = 2/112 (1%)
Query: 154 DGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTF 213
D +G S +H AA G ++A L+ VD+ D NGM PL +AA++ ++P RLLL
Sbjct: 46 DADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGR-LEPVRLLLRA 104
Query: 214 NVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLA 265
+ +VN LH A G+ V +LL+ +N N ++ LDLA
Sbjct: 105 SAAVNAA-SLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLA 155
Score = 37.4 bits (85), Expect = 0.042
Identities = 35/120 (29%), Positives = 50/120 (41%), Gaps = 2/120 (1%)
Query: 128 LHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMD 187
LH A G L ++ L++ A + D G +H AA G V L+ V+
Sbjct: 53 LHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAAS 112
Query: 188 QNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEA 247
+G PL AA H + + +LL + L +K K T L A G V LLL +
Sbjct: 113 LDGQIPLHLAAQYGH-YEVSEMLLQHQSNPCLVNK-AKKTPLDLACEFGRLKVAQLLLNS 170
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 87.8 bits (216), Expect = 3e-17
Identities = 61/214 (28%), Positives = 107/214 (50%), Gaps = 3/214 (1%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A +YG E L++ K +T LH AA + + + +GA +
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKN- 630
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 183
TPLH A ++ + + L++YGAD + + +G + +HLAAQ GH +V+ L+ + +V
Sbjct: 631 GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV 690
Query: 184 DMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISL 243
++ +++G+TPL AA + V+ +L+ V+ K T LH GN +++
Sbjct: 691 NLSNKSGLTPLHLAA-QEDRVNVAEVLVNQGAHVDAQTKM-GYTPLHVGCHYGNIKIVNF 748
Query: 244 LLEAGANVDAQNIKGESALDLAKQRKNVWMINHL 277
LL+ A V+A+ G + L A Q+ + +IN L
Sbjct: 749 LLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVL 782
Score = 84.3 bits (207), Expect = 3e-16
Identities = 68/232 (29%), Positives = 111/232 (47%), Gaps = 3/232 (1%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A + G E R LV+ G V K++ T LH +A + D+V+ + +GA +
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS- 531
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 183
TPLH + R+GH + L+ +GA S+ +G + +H+AA++G + L+ K
Sbjct: 532 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP 591
Query: 184 DMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISL 243
D ++G+TPL AA+ + LLL S + K + T LH A + +
Sbjct: 592 DAAGKSGLTPLHVAAHYDNQ-KVALLLLDQGASPHAAAK-NGYTPLHIAAKKNQMDIATT 649
Query: 244 LLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKL 295
LLE GA+ +A +G +++ LA Q +V M++ L N S L L
Sbjct: 650 LLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPL 701
Score = 83.6 bits (205), Expect = 5e-16
Identities = 69/245 (28%), Positives = 112/245 (45%), Gaps = 4/245 (1%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A G Y+ + L++ + T LH A NRI +++ + GA + Q +
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASI-QAVTES 432
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 183
TP+H A GH+++V QLM +GA P+ + G + +H+AA+ G +V YL+ G V
Sbjct: 433 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV 492
Query: 184 DMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISL 243
+ ++ TPL +A R D + LL S N T LH + G+ V +
Sbjct: 493 EAKAKDDQTPLHISA-RLGKADIVQQLLQQGASPNAATT-SGYTPLHLSAREGHEDVAAF 550
Query: 244 LLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKLKADKEF-R 302
LL+ GA++ KG + L +A + + + N L + + S L L +
Sbjct: 551 LLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDN 610
Query: 303 QKVML 307
QKV L
Sbjct: 611 QKVAL 615
Score = 75.5 bits (184), Expect = 1e-13
Identities = 56/185 (30%), Positives = 97/185 (52%), Gaps = 5/185 (2%)
Query: 88 KENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYG 147
K T LH AA I++ +++ A VD + + TPLH A+++G+ +MV L+ G
Sbjct: 233 KSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARN-DITPLHVASKRGNANMVKLLLDRG 291
Query: 148 ADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPT 207
A +G + +H A+ GH +V L+ + + +NG++PL A H ++
Sbjct: 292 AKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDH-LNCV 350
Query: 208 RLLLTFNVSV-NLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAK 266
+LLL NV V ++ + Y TALH A G+ V +LL+ AN +A+ + G + L +A
Sbjct: 351 QLLLQHNVPVDDVTNDY--LTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIAC 408
Query: 267 QRKNV 271
++ +
Sbjct: 409 KKNRI 413
Score = 72.0 bits (175), Expect = 2e-12
Identities = 53/198 (26%), Positives = 88/198 (44%), Gaps = 3/198 (1%)
Query: 74 RELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATR 133
++L++ G T LH +A D+ + + GA + + TPLH A +
Sbjct: 516 QQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS-ITTKKGFTPLHVAAK 574
Query: 134 QGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTP 193
G L + L++ A P G + +H+AA + + + L+ +G +NG TP
Sbjct: 575 YGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTP 634
Query: 194 LMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDA 253
L AA + + +D LL + N + ++H A G+ ++SLLL ANV+
Sbjct: 635 LHIAA-KKNQMDIATTLLEYGADANAVTR-QGIASVHLAAQEGHVDMVSLLLGRNANVNL 692
Query: 254 QNIKGESALDLAKQRKNV 271
N G + L LA Q V
Sbjct: 693 SNKSGLTPLHLAAQEDRV 710
Score = 70.1 bits (170), Expect = 6e-12
Identities = 63/216 (29%), Positives = 100/216 (46%), Gaps = 11/216 (5%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A++ G E EL++ +V K+ T LH A++ + ++VK ++ GA V+ +
Sbjct: 81 ASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQN- 139
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 183
TPL+ A ++ HL +V L+ GA SL +G + + +A Q GH +V+ L+
Sbjct: 140 GFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN---- 195
Query: 184 DMMDQNGMT--PLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVI 241
D G P + A R LLL + + ++ K T LH A GN V
Sbjct: 196 ---DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESK-SGFTPLHIAAHYGNINVA 251
Query: 242 SLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHL 277
+LLL A VD + L +A +R N M+ L
Sbjct: 252 TLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLL 287
Score = 69.3 bits (168), Expect = 1e-11
Identities = 52/210 (24%), Positives = 97/210 (46%), Gaps = 7/210 (3%)
Query: 62 VKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGG 121
++A + G E+ + ++ G D+ ++ + LH A+ +++V + + A VD
Sbjct: 46 LRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVD-AAT 104
Query: 122 DLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQ 181
+T LH A+ G +V L+ GA+ + G + +++AAQ H +V +L+ G
Sbjct: 105 KKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164
Query: 182 DVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVI 241
+ ++G TPL A + H LLL + + + ALH A +T
Sbjct: 165 SQSLATEDGFTPLAVALQQGHD-QVVSLLLENDTKGKV-----RLPALHIAARKDDTKAA 218
Query: 242 SLLLEAGANVDAQNIKGESALDLAKQRKNV 271
+LLL+ N D ++ G + L +A N+
Sbjct: 219 ALLLQNDNNADVESKSGFTPLHIAAHYGNI 248
Score = 65.1 bits (157), Expect = 2e-10
Identities = 54/179 (30%), Positives = 90/179 (50%), Gaps = 10/179 (5%)
Query: 71 ERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGA---IVDQLGGDLNSTP 127
E+ R+ + D ++ N + L AA ++ YI G I +Q G LN+
Sbjct: 23 EKKRKHRKRSRDRKKKSDANASYLR-AARAGHLEKALDYIKNGVDINICNQNG--LNA-- 77
Query: 128 LHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMD 187
LH A+++GH+ +V +L++ A+ +G + +H+A+ G +V L+ G +V+
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137
Query: 188 QNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLE 246
QNG TPL AA H ++ + LL S +L + T L A+ G+ V+SLLLE
Sbjct: 138 QNGFTPLYMAAQENH-LEVVKFLLDNGASQSLATE-DGFTPLAVALQQGHDQVVSLLLE 194
Score = 64.3 bits (155), Expect = 3e-10
Identities = 46/190 (24%), Positives = 87/190 (45%), Gaps = 3/190 (1%)
Query: 76 LVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQG 135
L++ + K ++ LH A + ++ V+ + VD + D T LH A G
Sbjct: 320 LLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDY-LTALHVAAHCG 378
Query: 136 HLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLM 195
H + L+ A+P+ G + +H+A + ++ L+ G + + ++G+TP+
Sbjct: 379 HYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIH 438
Query: 196 WAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQN 255
AA+ H V+ L+ S N TALH A +G V+ L++ GA V+A+
Sbjct: 439 VAAFMGH-VNIVSQLMHHGASPNT-TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKA 496
Query: 256 IKGESALDLA 265
++ L ++
Sbjct: 497 KDDQTPLHIS 506
Score = 63.9 bits (154), Expect = 4e-10
Identities = 44/156 (28%), Positives = 72/156 (46%), Gaps = 36/156 (23%)
Query: 122 DLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQ 181
D N++ L A R GHL + +K G D ++ + G + +HLA++ GH +V+ L+ +
Sbjct: 40 DANASYLR-AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREA 98
Query: 182 DVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVI 241
+VD + G NTALH A LAG V+
Sbjct: 99 NVDAATKKG-----------------------------------NTALHIASLAGQAEVV 123
Query: 242 SLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHL 277
+L+ GANV+AQ+ G + L +A Q ++ ++ L
Sbjct: 124 KVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFL 159
Score = 59.7 bits (143), Expect = 8e-09
Identities = 56/233 (24%), Positives = 105/233 (45%), Gaps = 32/233 (13%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A+ G E + LV G +V + T L+ AA N +++VK+ + GA L +
Sbjct: 114 ASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATED 172
Query: 124 NSTPLHWATRQGH---LSMVVQ--------------------------LMKYGADPSLID 154
TPL A +QGH +S++++ L++ + +
Sbjct: 173 GFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVES 232
Query: 155 GEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFN 214
G + +H+AA +G+ ++ L+ + VD +N +TPL A+ R ++ + +LLL
Sbjct: 233 KSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNA-NMVKLLLDRG 291
Query: 215 VSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQ 267
++ + T LH +G+ V+ +LL+ A + ++ G S L +A Q
Sbjct: 292 AKIDAKTR-DGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQ 343
Score = 57.0 bits (136), Expect = 5e-08
Identities = 38/131 (29%), Positives = 65/131 (49%), Gaps = 1/131 (0%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A Q G + L+ +V +K +T LH AA +R+++ + +++GA VD +
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT-KM 729
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 183
TPLH G++ +V L+++ A + G + +H AAQ GHT I+ L+
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASP 789
Query: 184 DMMDQNGMTPL 194
+ + NG T L
Sbjct: 790 NELTVNGNTAL 800
>gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1139
Score = 87.4 bits (215), Expect = 4e-17
Identities = 75/277 (27%), Positives = 135/277 (48%), Gaps = 24/277 (8%)
Query: 45 EPLGRKTHIDDYSTWDIVKATQYGI---YERCRELVEAGYDVRQPDKENVTLLHWAAINN 101
E GR HI D+ I +A G E C DVR D+++ T+LH A +
Sbjct: 150 EYAGRGYHIRDWELRKIHRAAIKGDAAEVEHCLTRRFRDLDVR--DRKDRTVLHLACAHG 207
Query: 102 RIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCI 161
R+ +V + + ++ + LN TPL A + + L+K GA+P++ D G + +
Sbjct: 208 RVQVVTLLLDRKCQIN-ICDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTAL 266
Query: 162 HLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWA--AYRTHSVDPTRLLLTFNVSVNL 219
H A TS+ L++ +++ +++ G TPL++A + R H V+ LL +++
Sbjct: 267 HYAVYNEGTSLAERLLSHHANIEALNKEGNTPLLFAINSRRQHMVE---FLLKNQANIHA 323
Query: 220 GDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLA------------KQ 267
D + K TAL AV +++++LLL+ ++ +Q++ G++A D A +
Sbjct: 324 VDNF-KRTALILAVQHNLSSIVTLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILE 382
Query: 268 RKNVWMINHLQEARQAKGYDNPSFLRKLKADKEFRQK 304
KN + NHL+ Q P L+K K K+ +++
Sbjct: 383 HKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKR 419
>gi|148596917 fibronectin type III and ankyrin repeat domains 1
[Homo sapiens]
Length = 345
Score = 87.4 bits (215), Expect = 4e-17
Identities = 63/198 (31%), Positives = 102/198 (51%), Gaps = 3/198 (1%)
Query: 86 PDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMK 145
P+K T L AA LVK +S G V+ G L A GHL +V L +
Sbjct: 140 PNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGS-GKDSLMLACYAGHLDVVKYLRR 198
Query: 146 YGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQ-NGMTPLMWAAYRTHSV 204
+GA D GC+ +H AA GH S++ ++I G +VD++D +G TPLM + + +
Sbjct: 199 HGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQ 258
Query: 205 DPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDL 264
LL+ +VN+ D+ K T L AVL + ++ LLL+ GA+ +N G+ L++
Sbjct: 259 RVASLLIDAGANVNVKDRNGK-TPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEM 317
Query: 265 AKQRKNVWMINHLQEARQ 282
A+ +++ L+E ++
Sbjct: 318 ARVFDRQSVVSLLEERKK 335
Score = 70.9 bits (172), Expect = 3e-12
Identities = 58/190 (30%), Positives = 92/190 (48%), Gaps = 9/190 (4%)
Query: 61 IVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAI--VDQ 118
++ A Q G + LV G DV + L A +D+VKY GA
Sbjct: 148 LMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARD 207
Query: 119 LGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLID-GEGCS-CIHLAAQFGHTSIVAYL 176
LGG T LHWA GH S++ ++K G + ++D G G + + ++A G+ + + L
Sbjct: 208 LGG---CTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLL 264
Query: 177 IAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAG 236
I G +V++ D+NG TPLM A H + +LLL ++ +++ K L A +
Sbjct: 265 IDAGANVNVKDRNGKTPLMVAVLNNHE-ELVQLLLDKGADASVKNEFGKG-VLEMARVFD 322
Query: 237 NTTVISLLLE 246
+V+SLL E
Sbjct: 323 RQSVVSLLEE 332
Score = 66.2 bits (160), Expect = 9e-11
Identities = 52/173 (30%), Positives = 80/173 (46%), Gaps = 2/173 (1%)
Query: 94 LHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLI 153
LH A N DL+ + G + + T L A ++G+ +V L+ G D +L
Sbjct: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
Query: 154 DGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTF 213
+G G + LA GH +V YL G D G T L WAA H ++
Sbjct: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGH-CSVIEWMIKD 232
Query: 214 NVSVNLGDKYHKNTAL-HWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLA 265
V++ D T L + ++GN V SLL++AGANV+ ++ G++ L +A
Sbjct: 233 GCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVA 285
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 86.7 bits (213), Expect = 6e-17
Identities = 66/206 (32%), Positives = 103/206 (50%), Gaps = 9/206 (4%)
Query: 76 LVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGA---IVDQLGGDLNSTPLHWAT 132
L+E G K T LH AA N++ + ++ GA IV + G TPLH A+
Sbjct: 594 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG----VTPLHLAS 649
Query: 133 RQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMT 192
++GH MV L+ GA+ + G + +HLAAQ ++ L G D D + G T
Sbjct: 650 QEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 709
Query: 193 PLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVD 252
PL+ A + + V LL +VN K + T LH A G+T +I++LL+ GA +
Sbjct: 710 PLIVACHYGN-VKMVNFLLKQGANVNAKTK-NGYTPLHQAAQQGHTHIINVLLQHGAKPN 767
Query: 253 AQNIKGESALDLAKQRKNVWMINHLQ 278
A G +AL +AK+ + +++ L+
Sbjct: 768 ATTANGNTALAIAKRLGYISVVDTLK 793
Score = 84.7 bits (208), Expect = 2e-16
Identities = 62/214 (28%), Positives = 106/214 (49%), Gaps = 3/214 (1%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A +YG + + L++ K +T LH AA + + + KGA +
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN- 607
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 183
TPLH A ++ + + L+ YGA+ +++ +G + +HLA+Q GHT +V L+ KG ++
Sbjct: 608 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 667
Query: 184 DMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISL 243
M ++G+T L AA + V+ +L + K T L A GN +++
Sbjct: 668 HMSTKSGLTSLHLAA-QEDKVNVADILTKHGADQDAHTKL-GYTPLIVACHYGNVKMVNF 725
Query: 244 LLEAGANVDAQNIKGESALDLAKQRKNVWMINHL 277
LL+ GANV+A+ G + L A Q+ + +IN L
Sbjct: 726 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 759
Score = 77.8 bits (190), Expect = 3e-14
Identities = 68/256 (26%), Positives = 111/256 (43%), Gaps = 36/256 (14%)
Query: 57 STWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIV 116
S ++A + G ++ E ++ G D+ ++ + LH AA + LV+ + +G+ V
Sbjct: 10 SNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSV 69
Query: 117 DQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYL 176
D +T LH A+ G +V L+K GA+ + G + +++AAQ H +V YL
Sbjct: 70 DS-ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128
Query: 177 IAKGQDVDMMDQNGMTPLMWAAYRTHS-------------------------VDPTR--- 208
+ G + ++G TPL A + H+ D T+
Sbjct: 129 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 188
Query: 209 LLLTFNVSVNLGDKYHKN-------TALHWAVLAGNTTVISLLLEAGANVDAQNIKGESA 261
LLL + + ++ K N T LH A GN V +LLL GA VD G +
Sbjct: 189 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 248
Query: 262 LDLAKQRKNVWMINHL 277
L +A +R N M+ L
Sbjct: 249 LHVASKRGNTNMVKLL 264
Score = 77.0 bits (188), Expect = 5e-14
Identities = 69/240 (28%), Positives = 105/240 (43%), Gaps = 34/240 (14%)
Query: 76 LVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGD------------- 122
L+E G + K ++ LH AA + ++ VK+ + A VD + D
Sbjct: 297 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 356
Query: 123 ------------------LNS-TPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHL 163
LN TPLH A ++ + ++ L+KYGA I G + IH+
Sbjct: 357 YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHV 416
Query: 164 AAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKY 223
AA GH +IV L+ G D+ + G T L AA R V+ R LL V+ +
Sbjct: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAA-RAGQVEVVRCLLRNGALVDARAR- 474
Query: 224 HKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQA 283
+ T LH A G T ++ LLL+ A+ DA G + L ++ + V + + L EA A
Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 534
Score = 76.6 bits (187), Expect = 6e-14
Identities = 57/195 (29%), Positives = 98/195 (50%), Gaps = 3/195 (1%)
Query: 77 VEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGH 136
V++ V + + T LH AA +++ +++GA VD + TPLH A+++G+
Sbjct: 199 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN-GITPLHVASKRGN 257
Query: 137 LSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMW 196
+MV L+ G +G + +H AA+ GH +V L+ +G + +NG++PL
Sbjct: 258 TNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHM 317
Query: 197 AAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNI 256
AA H V+ + LL V+ TALH A G+ V LLL+ AN +A+ +
Sbjct: 318 AAQGDH-VECVKHLLQHKAPVD-DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 375
Query: 257 KGESALDLAKQRKNV 271
G + L +A ++ +
Sbjct: 376 NGFTPLHIACKKNRI 390
Score = 75.9 bits (185), Expect = 1e-13
Identities = 75/273 (27%), Positives = 120/273 (43%), Gaps = 43/273 (15%)
Query: 45 EPLGRKTHIDDYS---TWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINN 101
E LGR + +D + + A+ G E + LV+ G ++ + T L+ AA N
Sbjct: 61 ELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQEN 120
Query: 102 RIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMK---------------- 145
ID+VKY + GA D TPL A +QGH V L++
Sbjct: 121 HIDVVKYLLENGANQSTATED-GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAA 179
Query: 146 ---------------YGAD------PSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVD 184
+ AD + G + +H+AA +G+ ++ L+ +G VD
Sbjct: 180 RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 239
Query: 185 MMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLL 244
+NG+TPL A+ R ++ + +LLL ++ + T LH A +G+ V+ LL
Sbjct: 240 FTARNGITPLHVASKRGNT-NMVKLLLDRGGQIDAKTR-DGLTPLHCAARSGHDQVVELL 297
Query: 245 LEAGANVDAQNIKGESALDLAKQRKNVWMINHL 277
LE GA + A+ G S L +A Q +V + HL
Sbjct: 298 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 330
Score = 75.1 bits (183), Expect = 2e-13
Identities = 64/217 (29%), Positives = 102/217 (47%), Gaps = 4/217 (1%)
Query: 92 TLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPS 151
T LH A NRI +++ + GA + + + TP+H A GHL++V+ L++ GA P
Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAIT-ESGLTPIHVAAFMGHLNIVLLLLQNGASPD 437
Query: 152 LIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLL 211
+ + G + +H+AA+ G +V L+ G VD + TPL A+ R + +LLL
Sbjct: 438 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIAS-RLGKTEIVQLLL 496
Query: 212 TFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNV 271
+ + T LH + G V S+LLEAGA KG + L +A + ++
Sbjct: 497 QHMAHPDAATT-NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL 555
Query: 272 WMINHLQEARQAKGYDNPSFLRKLKADKEF-RQKVML 307
+ L + R A + L L + QKV L
Sbjct: 556 DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL 592
Score = 70.9 bits (172), Expect = 3e-12
Identities = 67/261 (25%), Positives = 111/261 (42%), Gaps = 40/261 (15%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A + G E R L+ G V +E T LH A+ + ++V+ + A D +
Sbjct: 450 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTN- 508
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 183
TPLH + R+G + + L++ GA SL +G + +H+AA++G + L+ +
Sbjct: 509 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 568
Query: 184 DMMDQNGMTPLMWAAY--------------------------------RTHSVDPTRLLL 211
D +NG+TPL AA+ + + + LL
Sbjct: 569 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 628
Query: 212 TFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNV 271
+ N+ K T LH A G+T +++LLL+ GAN+ G ++L LA Q V
Sbjct: 629 NYGAETNIVTK-QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKV 687
Query: 272 WMINHL------QEARQAKGY 286
+ + L Q+A GY
Sbjct: 688 NVADILTKHGADQDAHTKLGY 708
Score = 69.3 bits (168), Expect = 1e-11
Identities = 44/149 (29%), Positives = 70/149 (46%), Gaps = 35/149 (23%)
Query: 131 ATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNG 190
A R G+L VV+ +K G D + + G + +HLAA+ GH +V L+ +G VD + G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 191 MTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGAN 250
NTALH A LAG V+ +L++ GAN
Sbjct: 77 -----------------------------------NTALHIASLAGQAEVVKVLVKEGAN 101
Query: 251 VDAQNIKGESALDLAKQRKNVWMINHLQE 279
++AQ+ G + L +A Q ++ ++ +L E
Sbjct: 102 INAQSQNGFTPLYMAAQENHIDVVKYLLE 130
Score = 64.7 bits (156), Expect = 2e-10
Identities = 47/164 (28%), Positives = 76/164 (46%), Gaps = 8/164 (4%)
Query: 85 QPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLM 144
Q N + L A N +V+Y KG I LH A ++GH+ +V +L+
Sbjct: 6 QKSDSNASFLRAARAGNLDKVVEYL--KGGIDINTCNQNGLNALHLAAKEGHVGLVQELL 63
Query: 145 KYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSV 204
G+ +G + +H+A+ G +V L+ +G +++ QNG TPL AA H +
Sbjct: 64 GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH-I 122
Query: 205 DPTRLLLT--FNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLE 246
D + LL N S D + T L A+ G+ +++LLE
Sbjct: 123 DVVKYLLENGANQSTATEDGF---TPLAVALQQGHNQAVAILLE 163
Score = 57.8 bits (138), Expect = 3e-08
Identities = 41/131 (31%), Positives = 63/131 (48%), Gaps = 1/131 (0%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A+Q G + L++ G ++ K +T LH AA +++++ GA D L
Sbjct: 648 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA-HTKL 706
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 183
TPL A G++ MV L+K GA+ + G + +H AAQ GHT I+ L+ G
Sbjct: 707 GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 766
Query: 184 DMMDQNGMTPL 194
+ NG T L
Sbjct: 767 NATTANGNTAL 777
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 86.7 bits (213), Expect = 6e-17
Identities = 66/206 (32%), Positives = 103/206 (50%), Gaps = 9/206 (4%)
Query: 76 LVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGA---IVDQLGGDLNSTPLHWAT 132
L+E G K T LH AA N++ + ++ GA IV + G TPLH A+
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG----VTPLHLAS 670
Query: 133 RQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMT 192
++GH MV L+ GA+ + G + +HLAAQ ++ L G D D + G T
Sbjct: 671 QEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730
Query: 193 PLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVD 252
PL+ A + + V LL +VN K + T LH A G+T +I++LL+ GA +
Sbjct: 731 PLIVACHYGN-VKMVNFLLKQGANVNAKTK-NGYTPLHQAAQQGHTHIINVLLQHGAKPN 788
Query: 253 AQNIKGESALDLAKQRKNVWMINHLQ 278
A G +AL +AK+ + +++ L+
Sbjct: 789 ATTANGNTALAIAKRLGYISVVDTLK 814
Score = 84.7 bits (208), Expect = 2e-16
Identities = 62/214 (28%), Positives = 106/214 (49%), Gaps = 3/214 (1%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A +YG + + L++ K +T LH AA + + + KGA +
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN- 628
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 183
TPLH A ++ + + L+ YGA+ +++ +G + +HLA+Q GHT +V L+ KG ++
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Query: 184 DMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISL 243
M ++G+T L AA + V+ +L + K T L A GN +++
Sbjct: 689 HMSTKSGLTSLHLAA-QEDKVNVADILTKHGADQDAHTKL-GYTPLIVACHYGNVKMVNF 746
Query: 244 LLEAGANVDAQNIKGESALDLAKQRKNVWMINHL 277
LL+ GANV+A+ G + L A Q+ + +IN L
Sbjct: 747 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
Score = 78.2 bits (191), Expect = 2e-14
Identities = 71/269 (26%), Positives = 114/269 (42%), Gaps = 36/269 (13%)
Query: 44 GEPLGRKTHIDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRI 103
G RK S ++A + G ++ E ++ G D+ ++ + LH AA +
Sbjct: 18 GSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHV 77
Query: 104 DLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHL 163
LV+ + +G+ VD +T LH A+ G +V L+K GA+ + G + +++
Sbjct: 78 GLVQELLGRGSSVDS-ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYM 136
Query: 164 AAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHS-------------------- 203
AAQ H +V YL+ G + ++G TPL A + H+
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPAL 196
Query: 204 -----VDPTR---LLLTFNVSVNLGDKYHKN-------TALHWAVLAGNTTVISLLLEAG 248
D T+ LLL + + ++ K N T LH A GN V +LLL G
Sbjct: 197 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256
Query: 249 ANVDAQNIKGESALDLAKQRKNVWMINHL 277
A VD G + L +A +R N M+ L
Sbjct: 257 AAVDFTARNGITPLHVASKRGNTNMVKLL 285
Score = 77.0 bits (188), Expect = 5e-14
Identities = 69/240 (28%), Positives = 105/240 (43%), Gaps = 34/240 (14%)
Query: 76 LVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGD------------- 122
L+E G + K ++ LH AA + ++ VK+ + A VD + D
Sbjct: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 377
Query: 123 ------------------LNS-TPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHL 163
LN TPLH A ++ + ++ L+KYGA I G + IH+
Sbjct: 378 YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHV 437
Query: 164 AAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKY 223
AA GH +IV L+ G D+ + G T L AA R V+ R LL V+ +
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAA-RAGQVEVVRCLLRNGALVDARAR- 495
Query: 224 HKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQA 283
+ T LH A G T ++ LLL+ A+ DA G + L ++ + V + + L EA A
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Score = 76.6 bits (187), Expect = 6e-14
Identities = 57/195 (29%), Positives = 98/195 (50%), Gaps = 3/195 (1%)
Query: 77 VEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGH 136
V++ V + + T LH AA +++ +++GA VD + TPLH A+++G+
Sbjct: 220 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN-GITPLHVASKRGN 278
Query: 137 LSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMW 196
+MV L+ G +G + +H AA+ GH +V L+ +G + +NG++PL
Sbjct: 279 TNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHM 338
Query: 197 AAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNI 256
AA H V+ + LL V+ TALH A G+ V LLL+ AN +A+ +
Sbjct: 339 AAQGDH-VECVKHLLQHKAPVD-DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL 396
Query: 257 KGESALDLAKQRKNV 271
G + L +A ++ +
Sbjct: 397 NGFTPLHIACKKNRI 411
Score = 75.9 bits (185), Expect = 1e-13
Identities = 75/273 (27%), Positives = 120/273 (43%), Gaps = 43/273 (15%)
Query: 45 EPLGRKTHIDDYS---TWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINN 101
E LGR + +D + + A+ G E + LV+ G ++ + T L+ AA N
Sbjct: 82 ELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQEN 141
Query: 102 RIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMK---------------- 145
ID+VKY + GA D TPL A +QGH V L++
Sbjct: 142 HIDVVKYLLENGANQSTATED-GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAA 200
Query: 146 ---------------YGAD------PSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVD 184
+ AD + G + +H+AA +G+ ++ L+ +G VD
Sbjct: 201 RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 260
Query: 185 MMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLL 244
+NG+TPL A+ R ++ + +LLL ++ + T LH A +G+ V+ LL
Sbjct: 261 FTARNGITPLHVASKRGNT-NMVKLLLDRGGQIDAKTR-DGLTPLHCAARSGHDQVVELL 318
Query: 245 LEAGANVDAQNIKGESALDLAKQRKNVWMINHL 277
LE GA + A+ G S L +A Q +V + HL
Sbjct: 319 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351
Score = 75.1 bits (183), Expect = 2e-13
Identities = 64/217 (29%), Positives = 102/217 (47%), Gaps = 4/217 (1%)
Query: 92 TLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPS 151
T LH A NRI +++ + GA + + + TP+H A GHL++V+ L++ GA P
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAIT-ESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458
Query: 152 LIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLL 211
+ + G + +H+AA+ G +V L+ G VD + TPL A+ R + +LLL
Sbjct: 459 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIAS-RLGKTEIVQLLL 517
Query: 212 TFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNV 271
+ + T LH + G V S+LLEAGA KG + L +A + ++
Sbjct: 518 QHMAHPDAATT-NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL 576
Query: 272 WMINHLQEARQAKGYDNPSFLRKLKADKEF-RQKVML 307
+ L + R A + L L + QKV L
Sbjct: 577 DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL 613
Score = 70.9 bits (172), Expect = 3e-12
Identities = 67/261 (25%), Positives = 111/261 (42%), Gaps = 40/261 (15%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A + G E R L+ G V +E T LH A+ + ++V+ + A D +
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTN- 529
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 183
TPLH + R+G + + L++ GA SL +G + +H+AA++G + L+ +
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
Query: 184 DMMDQNGMTPLMWAAY--------------------------------RTHSVDPTRLLL 211
D +NG+TPL AA+ + + + LL
Sbjct: 590 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
Query: 212 TFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNV 271
+ N+ K T LH A G+T +++LLL+ GAN+ G ++L LA Q V
Sbjct: 650 NYGAETNIVTK-QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKV 708
Query: 272 WMINHL------QEARQAKGY 286
+ + L Q+A GY
Sbjct: 709 NVADILTKHGADQDAHTKLGY 729
Score = 69.3 bits (168), Expect = 1e-11
Identities = 44/149 (29%), Positives = 70/149 (46%), Gaps = 35/149 (23%)
Query: 131 ATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNG 190
A R G+L VV+ +K G D + + G + +HLAA+ GH +V L+ +G VD + G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 191 MTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGAN 250
NTALH A LAG V+ +L++ GAN
Sbjct: 98 -----------------------------------NTALHIASLAGQAEVVKVLVKEGAN 122
Query: 251 VDAQNIKGESALDLAKQRKNVWMINHLQE 279
++AQ+ G + L +A Q ++ ++ +L E
Sbjct: 123 INAQSQNGFTPLYMAAQENHIDVVKYLLE 151
Score = 57.8 bits (138), Expect = 3e-08
Identities = 41/131 (31%), Positives = 63/131 (48%), Gaps = 1/131 (0%)
Query: 64 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 123
A+Q G + L++ G ++ K +T LH AA +++++ GA D L
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA-HTKL 727
Query: 124 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 183
TPL A G++ MV L+K GA+ + G + +H AAQ GHT I+ L+ G
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787
Query: 184 DMMDQNGMTPL 194
+ NG T L
Sbjct: 788 NATTANGNTAL 798
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.139 0.464
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,524,685
Number of Sequences: 37866
Number of extensions: 1083945
Number of successful extensions: 6321
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 371
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 2641
Number of HSP's gapped (non-prelim): 1723
length of query: 632
length of database: 18,247,518
effective HSP length: 108
effective length of query: 524
effective length of database: 14,157,990
effective search space: 7418786760
effective search space used: 7418786760
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.