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Search of human proteins with 10198656
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10198656 anti-Mullerian hormone receptor, type II [Homo
sapiens]
(573 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens] 1203 0.0
gi|15451916 bone morphogenetic protein receptor type II precurso... 286 5e-77
gi|116734708 activin A receptor, type IIB precursor [Homo sapiens] 210 3e-54
gi|4501897 activin A receptor, type IIA precursor [Homo sapiens] 203 3e-52
gi|4757720 activin A receptor, type IB isoform a precursor [Homo... 173 4e-43
gi|67782324 transforming growth factor, beta receptor II isoform... 171 1e-42
gi|67782326 transforming growth factor, beta receptor II isoform... 171 1e-42
gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens] 170 4e-42
gi|166235898 activin A receptor, type I precursor [Homo sapiens] 169 8e-42
gi|4501895 activin A receptor, type I precursor [Homo sapiens] 169 8e-42
gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens] 168 1e-41
gi|4759226 transforming growth factor, beta receptor I isoform 1... 167 2e-41
gi|195963412 transforming growth factor, beta receptor I isoform... 165 9e-41
gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens] 159 5e-39
gi|33598910 activin A receptor, type IB isoform b precursor [Hom... 159 9e-39
gi|4502431 bone morphogenetic protein receptor, type IB precurso... 157 3e-38
gi|41349437 bone morphogenetic protein receptor, type IA precurs... 152 6e-37
gi|116734714 activin A receptor type II-like 1 [Homo sapiens] 147 3e-35
gi|116734712 activin A receptor type II-like 1 [Homo sapiens] 147 3e-35
gi|33598912 activin A receptor, type IB isoform c precursor [Hom... 145 1e-34
gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens] 134 2e-31
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 75 2e-13
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 75 2e-13
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 74 3e-13
gi|4885489 v-mos Moloney murine sarcoma viral oncogene homolog [... 73 6e-13
gi|62420875 integrin-linked kinase [Homo sapiens] 71 3e-12
gi|62420873 integrin-linked kinase [Homo sapiens] 71 3e-12
gi|4758606 integrin-linked kinase [Homo sapiens] 71 3e-12
gi|187608615 tyrosine kinase 2 [Homo sapiens] 70 4e-12
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 70 5e-12
>gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens]
Length = 573
Score = 1203 bits (3113), Expect = 0.0
Identities = 573/573 (100%), Positives = 573/573 (100%)
Query: 1 MLGSLGLWALLPTAVEAPPNRRTCVFFEAPGVRGSTKTLGELLDTGTELPRAIRCLYSRC 60
MLGSLGLWALLPTAVEAPPNRRTCVFFEAPGVRGSTKTLGELLDTGTELPRAIRCLYSRC
Sbjct: 1 MLGSLGLWALLPTAVEAPPNRRTCVFFEAPGVRGSTKTLGELLDTGTELPRAIRCLYSRC 60
Query: 61 CFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANY 120
CFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANY
Sbjct: 61 CFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANY 120
Query: 121 SHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNYRVRGE 180
SHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNYRVRGE
Sbjct: 121 SHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNYRVRGE 180
Query: 181 PVPEPRPDSGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQF 240
PVPEPRPDSGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQF
Sbjct: 181 PVPEPRPDSGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQF 240
Query: 241 QAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGS 300
QAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGS
Sbjct: 241 QAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGS 300
Query: 301 SLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPG 360
SLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPG
Sbjct: 301 SLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPG 360
Query: 361 LTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEI 420
LTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEI
Sbjct: 361 LTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEI 420
Query: 421 LSRCPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDGL 480
LSRCPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDGL
Sbjct: 421 LSRCPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDGL 480
Query: 481 RELLEDCWDADPEARLTAECVQQRLAALAHPQESHPFPESCPRGCPPLCPEDCTSIPAPT 540
RELLEDCWDADPEARLTAECVQQRLAALAHPQESHPFPESCPRGCPPLCPEDCTSIPAPT
Sbjct: 481 RELLEDCWDADPEARLTAECVQQRLAALAHPQESHPFPESCPRGCPPLCPEDCTSIPAPT 540
Query: 541 ILPCRPQRSACHFSVQQGPCSRNPQPACTLSPV 573
ILPCRPQRSACHFSVQQGPCSRNPQPACTLSPV
Sbjct: 541 ILPCRPQRSACHFSVQQGPCSRNPQPACTLSPV 573
>gi|15451916 bone morphogenetic protein receptor type II precursor
[Homo sapiens]
Length = 1038
Score = 286 bits (731), Expect = 5e-77
Identities = 167/461 (36%), Positives = 252/461 (54%), Gaps = 19/461 (4%)
Query: 53 IRCLYSRCCFGIWNLTQDRAQVEMQGCRD--SDEPGCESLHCDPSPRAHPSPGSTLFTCS 110
I C C+G+W ++ + QGC D C C + T C
Sbjct: 58 ILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCC 117
Query: 111 CGTDFCNANYS-HLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILAL 169
C TD CN N++ + PPP + TP S E+I +AL + + +L++ L L
Sbjct: 118 CSTDLCNVNFTENFPPPDT--TPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRML 175
Query: 170 LQRKNYRVRGEPVPEPRPDSGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAI 229
+ + + E + + S++L L L ++I G + V+ G L + VA+
Sbjct: 176 TGDRKQGLHSMNMMEA---AASEPSLDLDNLKLL---ELIGRGRYGAVYKGSLDERPVAV 229
Query: 230 KAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCH 289
K F + F E+ +Y +P ++HD+I RFI LLV+E +P GSLC
Sbjct: 230 KVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCK 289
Query: 290 YLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAI 349
YL+ +TSDW SS R+A S+ +GLA+LH E + YKP I+HRDL+S+NVL++ DG+C I
Sbjct: 290 YLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVI 349
Query: 350 GDLGLALVLPG--LTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRR 407
D GL++ L G L +P + AAI E GT RYMAPE+L+ ++L+D AL++
Sbjct: 350 SDFGLSMRLTGNRLVRPGE------EDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQ 403
Query: 408 ADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIP 467
D+Y+L L+ WEI RC DL P S P +Q+A++ E+GN PT +++ L +E++RP P
Sbjct: 404 VDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFP 463
Query: 468 STWRCFATDPDGLRELLEDCWDADPEARLTAECVQQRLAAL 508
W+ + L+E +EDCWD D EARLTA+C ++R+A L
Sbjct: 464 EAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAEL 504
>gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]
Length = 512
Score = 210 bits (534), Expect = 3e-54
Identities = 145/457 (31%), Positives = 226/457 (49%), Gaps = 43/457 (9%)
Query: 61 CFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANY 120
C+ W + ++ +GC D + C + ++ C C +FCN +
Sbjct: 59 CYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEE-----NPQVYFCCCEGNFCNERF 113
Query: 121 SHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSI-ILALLQRKNYRVRG 179
+HLP G P + P AP LL + LL +G + ++ LL YR R
Sbjct: 114 THLPEAGGPEVT-YEPPPTAP--------TLLTVLAYSLLPIGGLSLIVLLAFWMYRHRK 164
Query: 180 EPVP--EPRPDSGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSV 237
P + D G L L L ++ G VW QL VA+K FP +
Sbjct: 165 PPYGHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDK 224
Query: 238 AQFQAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSD 297
+Q+ER ++ PG++H+++++FI A + G L L+ H KGSL YL
Sbjct: 225 QSWQSEREIFSTPGMKHENLLQFIAAEKRG-SNLEVELWLITAFHDKGSLTDYLKGNIIT 283
Query: 298 WGSSLRMALSLAQGLAFLHEE-RWQNGQ-YKPGIAHRDLSSQNVLIREDGSCAIGDLGLA 355
W +A ++++GL++LHE+ W G+ +KP IAHRD S+NVL++ D + + D GLA
Sbjct: 284 WNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLA 343
Query: 356 LVL-PGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLA 414
+ PG +PP T Q GT+RYMAPE+L+ ++ Q A R D+Y++
Sbjct: 344 VRFEPG--KPPGDTHGQ---------VGTRRYMAPEVLEGAINFQ--RDAFLRIDMYAMG 390
Query: 415 LLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFA 474
L+LWE++SRC D + L +E E+G P+ +EL + V ++ RP I W
Sbjct: 391 LVLWELVSRCK--AADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHW---- 444
Query: 475 TDPDGLREL---LEDCWDADPEARLTAECVQQRLAAL 508
GL +L +E+CWD D EARL+A CV++R++ +
Sbjct: 445 LKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLI 481
>gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]
Length = 513
Score = 203 bits (517), Expect = 3e-52
Identities = 148/493 (30%), Positives = 233/493 (47%), Gaps = 48/493 (9%)
Query: 24 CVFFEAPGVRGSTKTLGELLDTGTELPRAIRCLYSRCCFGIWNLTQDRAQVEMQGCRDSD 83
C+FF A + T G G + R R CF W ++ QGC D
Sbjct: 30 CLFFNANWEKDRTNQTGVEPCYGDKDKR-------RHCFATWKNISGSIEIVKQGCWLDD 82
Query: 84 EPGCESLHC-DPSPRAHPSPGSTLFTCSCGTDFCNANYSHLP------PPGSPGTPGSQG 136
++C D + ++ C C + CN +S+ P P +P TP
Sbjct: 83 ------INCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTP---- 132
Query: 137 PQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNYRVRGEPVPEPRPDSGRDWSVE 196
P +I LL + L+L+ G +I A +++++ PV P D G
Sbjct: 133 --KPPYYNI-----LLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSP 185
Query: 197 LQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDH 256
L L L +V G VW QL + VA+K FP + +Q E +Y LPG++H++
Sbjct: 186 LLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHEN 245
Query: 257 IVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLH 316
I++FI A + G + L+ H KGSL +L W +A ++A+GLA+LH
Sbjct: 246 ILQFIGAEKRGTS-VDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLH 304
Query: 317 EE-RWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGP 375
E+ +KP I+HRD+ S+NVL++ + + I D GLAL + G
Sbjct: 305 EDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEA-----GKSAGDTHG- 358
Query: 376 AAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPP 435
+ GT+RYMAPE+L+ ++ Q A R D+Y++ L+LWE+ SRC D
Sbjct: 359 ----QVGTRRYMAPEVLEGAINFQ--RDAFLRIDMYAMGLVLWELASRC--TAADGPVDE 410
Query: 436 FQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDGLRELLEDCWDADPEAR 495
+ L +E E+G P+ +++ + V +++RP + W+ A L E +E+CWD D EAR
Sbjct: 411 YMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHA-GMAMLCETIEECWDHDAEAR 469
Query: 496 LTAECVQQRLAAL 508
L+A CV +R+ +
Sbjct: 470 LSAGCVGERITQM 482
>gi|4757720 activin A receptor, type IB isoform a precursor [Homo
sapiens]
Length = 505
Score = 173 bits (438), Expect = 4e-43
Identities = 129/424 (30%), Positives = 205/424 (48%), Gaps = 40/424 (9%)
Query: 108 TCSCGTDFCNANYSHLPPPG--SPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLG-- 163
T C TD+CN +P P P GP G +L + +++ L++
Sbjct: 93 THCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYH 152
Query: 164 ---------------SIILALLQRKNYRVRGEPVPEPRPDSGRDWSVELQELPELCFSQV 208
S + L + K + + SG V+ + ++
Sbjct: 153 QRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEI 212
Query: 209 IREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGP 268
I +G VW G+ +G VA+K F R + E +Y+ L+H++I+ FI A
Sbjct: 213 IGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDN 272
Query: 269 GRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPG 328
G LV + H GSL YL +YT +++ALS A GLA LH E Q KPG
Sbjct: 273 GTWTQ-LWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEI-VGTQGKPG 330
Query: 329 IAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMA 388
IAHRDL S+N+L++++G CAI DLGLA+ +T P Q GT+RYMA
Sbjct: 331 IAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQ--------RVGTKRYMA 382
Query: 389 PELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTP 448
PE+LD+T++++ + + + ADIY+L L+ WEI RC +QL Y + + P
Sbjct: 383 PEVLDETINMKHFD-SFKCADIYALGLVYWEIARRC---NSGGVHEEYQLPYYDLVPSDP 438
Query: 449 TSDELWALAVQERRRPYIPSTWRCFATDPDGLR---ELLEDCWDADPEARLTAECVQQRL 505
+ +E+ + ++ RP IP+ W+ + + LR +++ +CW A+ ARLTA +++ L
Sbjct: 439 SIEEMRKVVCDQKLRPNIPNWWQSY----EALRVMGKMMRECWYANGAARLTALRIKKTL 494
Query: 506 AALA 509
+ L+
Sbjct: 495 SQLS 498
>gi|67782324 transforming growth factor, beta receptor II isoform B
precursor [Homo sapiens]
Length = 567
Score = 171 bits (434), Expect = 1e-42
Identities = 141/496 (28%), Positives = 228/496 (45%), Gaps = 82/496 (16%)
Query: 61 CFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDP-SPRA----HPSPGSTLFTCSCGTDF 115
C +W + +E C D P + + D SP+ PG T F CSC +D
Sbjct: 84 CVAVWRKNDENITLETV-CHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDE 142
Query: 116 CNANYSHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNY 175
CN N S+ + + + + + G+ LL L G I ++ Y
Sbjct: 143 CNDNIIF-----------SEEYNTSNPDLLLVIFQVTGISLLPPL--GVAISVIIIFYCY 189
Query: 176 RVRGEPVPEPRPDSGRDWSVELQELPELC-----------------------------FS 206
RV + ++G+ + +L E E C
Sbjct: 190 RVNRQQKLSSTWETGK--TRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELD 247
Query: 207 QVIREGGHAVVWAGQL------QGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRF 260
++ +G A V+ +L Q + VA+K FP A ++ E+ ++ L+H++I++F
Sbjct: 248 TLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQF 307
Query: 261 ITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERW 320
+TA L L+ H KG+L YLT++ W ++ SLA+G+A LH +
Sbjct: 308 LTAEERKT-ELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHT 366
Query: 321 QNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIM- 379
G+ K I HRDL S N+L++ D +C + D GL+L L PT A
Sbjct: 367 PCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRL---------DPTLSVDDLANSG 417
Query: 380 EAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLR--PDSSPPPFQ 437
+ GT RYMAPE+L+ ++L++ + ++ D+YS+AL+LWE+ SRC + D PP
Sbjct: 418 QVGTARYMAPEVLESRMNLEN-VESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPP--- 473
Query: 438 LAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDGLR---ELLEDCWDADPEA 494
+ +++ P + + +++R RP IPS W + G++ E L +CWD DPEA
Sbjct: 474 --FGSKVREHPCVESMKDNVLRDRGRPEIPSFW----LNHQGIQMVCETLTECWDHDPEA 527
Query: 495 RLTAECVQQRLAALAH 510
RLTA+CV +R + L H
Sbjct: 528 RLTAQCVAERFSELEH 543
>gi|67782326 transforming growth factor, beta receptor II isoform A
precursor [Homo sapiens]
Length = 592
Score = 171 bits (434), Expect = 1e-42
Identities = 141/496 (28%), Positives = 228/496 (45%), Gaps = 82/496 (16%)
Query: 61 CFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDP-SPRA----HPSPGSTLFTCSCGTDF 115
C +W + +E C D P + + D SP+ PG T F CSC +D
Sbjct: 109 CVAVWRKNDENITLETV-CHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDE 167
Query: 116 CNANYSHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNY 175
CN N S+ + + + + + G+ LL L G I ++ Y
Sbjct: 168 CNDNIIF-----------SEEYNTSNPDLLLVIFQVTGISLLPPL--GVAISVIIIFYCY 214
Query: 176 RVRGEPVPEPRPDSGRDWSVELQELPELC-----------------------------FS 206
RV + ++G+ + +L E E C
Sbjct: 215 RVNRQQKLSSTWETGK--TRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELD 272
Query: 207 QVIREGGHAVVWAGQL------QGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRF 260
++ +G A V+ +L Q + VA+K FP A ++ E+ ++ L+H++I++F
Sbjct: 273 TLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQF 332
Query: 261 ITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERW 320
+TA L L+ H KG+L YLT++ W ++ SLA+G+A LH +
Sbjct: 333 LTAEERKT-ELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHT 391
Query: 321 QNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIM- 379
G+ K I HRDL S N+L++ D +C + D GL+L L PT A
Sbjct: 392 PCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRL---------DPTLSVDDLANSG 442
Query: 380 EAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLR--PDSSPPPFQ 437
+ GT RYMAPE+L+ ++L++ + ++ D+YS+AL+LWE+ SRC + D PP
Sbjct: 443 QVGTARYMAPEVLESRMNLEN-VESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPP--- 498
Query: 438 LAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDGLR---ELLEDCWDADPEA 494
+ +++ P + + +++R RP IPS W + G++ E L +CWD DPEA
Sbjct: 499 --FGSKVREHPCVESMKDNVLRDRGRPEIPSFW----LNHQGIQMVCETLTECWDHDPEA 552
Query: 495 RLTAECVQQRLAALAH 510
RLTA+CV +R + L H
Sbjct: 553 RLTAQCVAERFSELEH 568
>gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens]
Length = 493
Score = 170 bits (430), Expect = 4e-42
Identities = 150/505 (29%), Positives = 231/505 (45%), Gaps = 72/505 (14%)
Query: 42 LLDTGTELPRAIRCLYSRC------------CFGIWNLTQDRAQVEMQGCRDSDEPGCES 89
LL EL ++C+ C C+ LT + QV ++ C E +
Sbjct: 15 LLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQV-IKSCVSLPELNAQV 73
Query: 90 LHCDPSPRAHPSPGSTLFTCSCGTDFCNANYSHLPPPGSPGTPGSQGPQAAPGESIWMAL 149
H S T C C TDFCN HLP T P+ P E +A+
Sbjct: 74 F-------CHSSNNVTKTEC-CFTDFCNNITLHLP------TASPNAPKLGPME---LAI 116
Query: 150 VLLGLFLLLLLLLGSIILALLQRK-NYRVRGEP-VPEPRPD------------------- 188
++ LL + + A R+ +YR + P V EP +
Sbjct: 117 IITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTA 176
Query: 189 ----SGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAER 244
SG V+ + +++ +G VW G+ G+ VA+K F R + E
Sbjct: 177 SGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREA 236
Query: 245 ALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRM 304
+Y+ L+H++I+ FI A G LV E H +GSL YL + +++
Sbjct: 237 EIYQTVMLRHENILGFIAADNKDNGTWTQ-LWLVSEYHEQGSLYDYLNRNIVTVAGMIKL 295
Query: 305 ALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQP 364
ALS+A GLA LH E Q KP IAHRD+ S+N+L+++ +CAI DLGLA+ +
Sbjct: 296 ALSIASGLAHLHMEI-VGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILN- 353
Query: 365 PAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRC 424
T PQ P + GT+RYMAPE+LD T+++ + + +RADIYS+ L+ WEI RC
Sbjct: 354 ---TIDIPQNP----KVGTKRYMAPEMLDDTMNVNIF-ESFKRADIYSVGLVYWEIARRC 405
Query: 425 PDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWR-CFATDPDGLREL 483
+QL Y + + P+ +E+ + ++ RP IP+ W+ C A G +
Sbjct: 406 ---SVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMG--RI 460
Query: 484 LEDCWDADPEARLTAECVQQRLAAL 508
+ +CW A+ ARLTA +++ ++ L
Sbjct: 461 MRECWYANGAARLTALRIKKTISQL 485
>gi|166235898 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 169 bits (427), Expect = 8e-42
Identities = 144/478 (30%), Positives = 222/478 (46%), Gaps = 62/478 (12%)
Query: 61 CFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANY 120
CF ++ D V +GC E G + C + PSPG + C D+CN N
Sbjct: 53 CFSSLSIN-DGFHVYQKGCFQVYEQG--KMTC----KTPPSPGQAVECCQ--GDWCNRNI 103
Query: 121 SHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNYRVRGE 180
+ P PG+Q G I L ++ LL LLG + +R R+
Sbjct: 104 TAQLPTKGKSFPGTQNFHLEVGLII---LSVVFAVCLLACLLGVALRKFKRRNQERLNPR 160
Query: 181 PVPEPRPD-------------------------SGRDWSVELQELPELCFSQVIREGGHA 215
V + SG + V+ ++ + + +G +
Sbjct: 161 DVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYG 220
Query: 216 VVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGPGRLLSGP 275
VW G QG+ VA+K F R + E LY L+H++I+ FI + R S
Sbjct: 221 EVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDM--TSRHSSTQ 278
Query: 276 L-LVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDL 334
L L+ H GSL YL T D S LR+ LS+A GLA LH E + Q KP IAHRDL
Sbjct: 279 LWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGT-QGKPAIAHRDL 337
Query: 335 SSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDK 394
S+N+L++++G C I DLGLA V+ + P+ GT+RYMAPE+LD+
Sbjct: 338 KSKNILVKKNGQCCIADLGLA-VMHSQSTNQLDVGNNPR-------VGTKRYMAPEVLDE 389
Query: 395 TLDLQDWGMALRRADIYSLALLLWEILSRCPD--LRPDSSPPPFQLAYEAELGNTPTSDE 452
T+ + D + +R DI++ L+LWE+ R + D PP + + + N P+ ++
Sbjct: 390 TIQV-DCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDV-----VPNDPSFED 443
Query: 453 LWALAVQERRRPYIPSTWRCFATDP--DGLRELLEDCWDADPEARLTAECVQQRLAAL 508
+ + +++RP IP+ W +DP L +L+++CW +P ARLTA +++ L +
Sbjct: 444 MRKVVCVDQQRPNIPNRW---FSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
>gi|4501895 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 169 bits (427), Expect = 8e-42
Identities = 144/478 (30%), Positives = 222/478 (46%), Gaps = 62/478 (12%)
Query: 61 CFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANY 120
CF ++ D V +GC E G + C + PSPG + C D+CN N
Sbjct: 53 CFSSLSIN-DGFHVYQKGCFQVYEQG--KMTC----KTPPSPGQAVECCQ--GDWCNRNI 103
Query: 121 SHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNYRVRGE 180
+ P PG+Q G I L ++ LL LLG + +R R+
Sbjct: 104 TAQLPTKGKSFPGTQNFHLEVGLII---LSVVFAVCLLACLLGVALRKFKRRNQERLNPR 160
Query: 181 PVPEPRPD-------------------------SGRDWSVELQELPELCFSQVIREGGHA 215
V + SG + V+ ++ + + +G +
Sbjct: 161 DVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYG 220
Query: 216 VVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGPGRLLSGP 275
VW G QG+ VA+K F R + E LY L+H++I+ FI + R S
Sbjct: 221 EVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDM--TSRHSSTQ 278
Query: 276 L-LVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDL 334
L L+ H GSL YL T D S LR+ LS+A GLA LH E + Q KP IAHRDL
Sbjct: 279 LWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGT-QGKPAIAHRDL 337
Query: 335 SSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDK 394
S+N+L++++G C I DLGLA V+ + P+ GT+RYMAPE+LD+
Sbjct: 338 KSKNILVKKNGQCCIADLGLA-VMHSQSTNQLDVGNNPR-------VGTKRYMAPEVLDE 389
Query: 395 TLDLQDWGMALRRADIYSLALLLWEILSRCPD--LRPDSSPPPFQLAYEAELGNTPTSDE 452
T+ + D + +R DI++ L+LWE+ R + D PP + + + N P+ ++
Sbjct: 390 TIQV-DCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDV-----VPNDPSFED 443
Query: 453 LWALAVQERRRPYIPSTWRCFATDP--DGLRELLEDCWDADPEARLTAECVQQRLAAL 508
+ + +++RP IP+ W +DP L +L+++CW +P ARLTA +++ L +
Sbjct: 444 MRKVVCVDQQRPNIPNRW---FSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
>gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens]
Length = 443
Score = 168 bits (426), Expect = 1e-41
Identities = 137/436 (31%), Positives = 210/436 (48%), Gaps = 52/436 (11%)
Query: 99 HPSPGSTLFTCSCGTDFCNANYSHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLL 158
H S T C C TDFCN HLP T P+ P E +A+++ LL
Sbjct: 26 HSSNNVTKTEC-CFTDFCNNITLHLP------TASPNAPKLGPME---LAIIITVPVCLL 75
Query: 159 LLLLGSIILALLQRK-NYRVRGEP-VPEPRPD-----------------------SGRDW 193
+ + A R+ +YR + P V EP + SG
Sbjct: 76 SIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPL 135
Query: 194 SVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQ 253
V+ + +++ +G VW G+ G+ VA+K F R + E +Y+ L+
Sbjct: 136 LVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLR 195
Query: 254 HDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLA 313
H++I+ FI A G LV E H +GSL YL + +++ALS+A GLA
Sbjct: 196 HENILGFIAADNKDNGTWTQ-LWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLA 254
Query: 314 FLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQ 373
LH E Q KP IAHRD+ S+N+L+++ +CAI DLGLA+ + T PQ
Sbjct: 255 HLHMEI-VGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILN----TIDIPQ 309
Query: 374 GPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSP 433
P + GT+RYMAPE+LD T+++ + + +RADIYS+ L+ WEI RC
Sbjct: 310 NP----KVGTKRYMAPEMLDDTMNVNIF-ESFKRADIYSVGLVYWEIARRC---SVGGIV 361
Query: 434 PPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWR-CFATDPDGLRELLEDCWDADP 492
+QL Y + + P+ +E+ + ++ RP IP+ W+ C A G ++ +CW A+
Sbjct: 362 EEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMG--RIMRECWYANG 419
Query: 493 EARLTAECVQQRLAAL 508
ARLTA +++ ++ L
Sbjct: 420 AARLTALRIKKTISQL 435
>gi|4759226 transforming growth factor, beta receptor I isoform 1
precursor [Homo sapiens]
Length = 503
Score = 167 bits (423), Expect = 2e-41
Identities = 137/447 (30%), Positives = 212/447 (47%), Gaps = 59/447 (13%)
Query: 92 CDPSPRAHPSPGSTLFTCSCGTDFCNANYSHLPPPGSPGTPGSQGPQAAPGESIWMALVL 151
C PS + GS T C D CN SPG GP + +A V+
Sbjct: 86 CAPSSKT----GSVTTTYCCNQDHCNKIELPTTVKSSPGL----GP-------VELAAVI 130
Query: 152 LG--LFLLLLLLLGSIILALLQRKNYRVRGEPVPE-PRP--------------------D 188
G F+ + L+L I ++RV E P RP
Sbjct: 131 AGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSG 190
Query: 189 SGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYE 248
SG V+ + + I +G VW G+ +G+ VA+K F R + E +Y+
Sbjct: 191 SGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQ 250
Query: 249 LPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSL 308
L+H++I+ FI A G LV + H GSL YL +YT +++ALS
Sbjct: 251 TVMLRHENILGFIAADNKDNGTWTQ-LWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALST 309
Query: 309 AQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWT 368
A GLA LH E Q KP IAHRDL S+N+L++++G+C I DLGLA+ T
Sbjct: 310 ASGLAHLHMEI-VGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIA 368
Query: 369 PTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCP--D 426
P GT+RYMAPE+LD +++++ + + +RADIY++ L+ WEI RC
Sbjct: 369 PNH--------RVGTKRYMAPEVLDDSINMKHF-ESFKRADIYAMGLVFWEIARRCSIGG 419
Query: 427 LRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWR-CFATDPDGLRELLE 485
+ D +QL Y + + P+ +E+ + +++ RP IP+ W+ C A + +++
Sbjct: 420 IHED-----YQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRV--MAKIMR 472
Query: 486 DCWDADPEARLTAECVQQRLAALAHPQ 512
+CW A+ ARLTA +++ L+ L+ +
Sbjct: 473 ECWYANGAARLTALRIKKTLSQLSQQE 499
>gi|195963412 transforming growth factor, beta receptor I isoform 2
precursor [Homo sapiens]
Length = 426
Score = 165 bits (418), Expect = 9e-41
Identities = 109/329 (33%), Positives = 176/329 (53%), Gaps = 21/329 (6%)
Query: 187 PDSGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERAL 246
P +G V+ + + I +G VW G+ +G+ VA+K F R + E +
Sbjct: 112 PTTGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEI 171
Query: 247 YELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMAL 306
Y+ L+H++I+ FI A G LV + H GSL YL +YT +++AL
Sbjct: 172 YQTVMLRHENILGFIAADNKDNGTWTQ-LWLVSDYHEHGSLFDYLNRYTVTVEGMIKLAL 230
Query: 307 SLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPA 366
S A GLA LH E Q KP IAHRDL S+N+L++++G+C I DLGLA+ T
Sbjct: 231 STASGLAHLHMEI-VGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTID 289
Query: 367 WTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCP- 425
P GT+RYMAPE+LD +++++ + + +RADIY++ L+ WEI RC
Sbjct: 290 IAPNH--------RVGTKRYMAPEVLDDSINMKHF-ESFKRADIYAMGLVFWEIARRCSI 340
Query: 426 -DLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWR-CFATDPDGLREL 483
+ D +QL Y + + P+ +E+ + +++ RP IP+ W+ C A + ++
Sbjct: 341 GGIHED-----YQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRV--MAKI 393
Query: 484 LEDCWDADPEARLTAECVQQRLAALAHPQ 512
+ +CW A+ ARLTA +++ L+ L+ +
Sbjct: 394 MRECWYANGAARLTALRIKKTLSQLSQQE 422
>gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens]
Length = 413
Score = 159 bits (403), Expect = 5e-39
Identities = 106/307 (34%), Positives = 167/307 (54%), Gaps = 17/307 (5%)
Query: 203 LCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFIT 262
+ +++ +G VW G+ G+ VA+K F R + E +Y+ L+H++I+ FI
Sbjct: 115 IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA 174
Query: 263 ASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQN 322
A G LV E H +GSL YL + +++ALS+A GLA LH E
Sbjct: 175 ADNKDNGTWTQ-LWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEI-VG 232
Query: 323 GQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAG 382
Q KP IAHRD+ S+N+L+++ +CAI DLGLA+ + T PQ P + G
Sbjct: 233 TQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILN----TIDIPQNP----KVG 284
Query: 383 TQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEA 442
T+RYMAPE+LD T+++ + + +RADIYS+ L+ WEI RC +QL Y
Sbjct: 285 TKRYMAPEMLDDTMNVNIF-ESFKRADIYSVGLVYWEIARRC---SVGGIVEEYQLPYYD 340
Query: 443 ELGNTPTSDELWALAVQERRRPYIPSTWR-CFATDPDGLRELLEDCWDADPEARLTAECV 501
+ + P+ +E+ + ++ RP IP+ W+ C A G ++ +CW A+ ARLTA +
Sbjct: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMG--RIMRECWYANGAARLTALRI 398
Query: 502 QQRLAAL 508
++ ++ L
Sbjct: 399 KKTISQL 405
>gi|33598910 activin A receptor, type IB isoform b precursor [Homo
sapiens]
Length = 476
Score = 159 bits (401), Expect = 9e-39
Identities = 117/385 (30%), Positives = 182/385 (47%), Gaps = 33/385 (8%)
Query: 108 TCSCGTDFCNANYSHLPPPG--SPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLG-- 163
T C TD+CN +P P P GP G +L + +++ L++
Sbjct: 93 THCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYH 152
Query: 164 ---------------SIILALLQRKNYRVRGEPVPEPRPDSGRDWSVELQELPELCFSQV 208
S + L + K + + SG V+ + ++
Sbjct: 153 QRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEI 212
Query: 209 IREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGP 268
I +G VW G+ +G VA+K F R + E +Y+ L+H++I+ FI A
Sbjct: 213 IGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDN 272
Query: 269 GRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPG 328
G LV + H GSL YL +YT +++ALS A GLA LH E Q KPG
Sbjct: 273 GTWTQ-LWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEI-VGTQGKPG 330
Query: 329 IAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMA 388
IAHRDL S+N+L++++G CAI DLGLA+ +T P Q GT+RYMA
Sbjct: 331 IAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQ--------RVGTKRYMA 382
Query: 389 PELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTP 448
PE+LD+T++++ + + + ADIY+L L+ WEI RC +QL Y + + P
Sbjct: 383 PEVLDETINMKHFD-SFKCADIYALGLVYWEIARRC---NSGGVHEEYQLPYYDLVPSDP 438
Query: 449 TSDELWALAVQERRRPYIPSTWRCF 473
+ +E+ + ++ RP IP+ W+ +
Sbjct: 439 SIEEMRKVVCDQKLRPNIPNWWQSY 463
>gi|4502431 bone morphogenetic protein receptor, type IB precursor
[Homo sapiens]
Length = 502
Score = 157 bits (396), Expect = 3e-38
Identities = 102/308 (33%), Positives = 162/308 (52%), Gaps = 21/308 (6%)
Query: 209 IREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGP 268
I +G + VW G+ +G+ VA+K F A + E +Y+ ++H++I+ FI A G
Sbjct: 210 IGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGT 269
Query: 269 GRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPG 328
G L+ + H GSL YL T D S L++A S GL LH E + Q KP
Sbjct: 270 GSWTQ-LYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFST-QGKPA 327
Query: 329 IAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMA 388
IAHRDL S+N+L++++G+C I DLGLA+ T P GT+RYM
Sbjct: 328 IAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPN--------TRVGTKRYMP 379
Query: 389 PELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTP 448
PE+LD++L+ + + AD+YS L+LWE+ RC +QL Y + + P
Sbjct: 380 PEVLDESLNRNHF-QSYIMADMYSFGLILWEVARRCVS---GGIVEEYQLPYHDLVPSDP 435
Query: 449 TSDELWALAVQERRRPYIPSTWRCFATDPDGLRE---LLEDCWDADPEARLTAECVQQRL 505
+ +++ + ++ RP P+ W + + LR+ L+ +CW +P +RLTA V++ L
Sbjct: 436 SYEDMREIVCIKKLRPSFPNRW----SSDECLRQMGKLMTECWAHNPASRLTALRVKKTL 491
Query: 506 AALAHPQE 513
A ++ Q+
Sbjct: 492 AKMSESQD 499
>gi|41349437 bone morphogenetic protein receptor, type IA precursor
[Homo sapiens]
Length = 532
Score = 152 bits (385), Expect = 6e-37
Identities = 132/486 (27%), Positives = 215/486 (44%), Gaps = 59/486 (12%)
Query: 55 CLYSRCCFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTD 114
C+ + CF I GC + C SP+A C C T+
Sbjct: 76 CITNGHCFAIIEEDDQGETTLASGCMKYEG---SDFQCKDSPKAQLR---RTIEC-CRTN 128
Query: 115 FCNANYSHLPPPGSPGTPGSQGPQAAPGESIWMALVL-LGLFLLLLLLLGSIIL------ 167
CN PP G G W+ L++ + + ++ +++ S
Sbjct: 129 LCNQYLQPTLPPVVIGP-------FFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCK 181
Query: 168 ALLQRKNYRVRGE------PVPEPRPD-----------SGRDWSVELQELPELCFSQVIR 210
++ R+ Y E PV E D SG V+ ++ + +
Sbjct: 182 SISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVG 241
Query: 211 EGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGPGR 270
+G + VW G+ +G+ VA+K F A + E +Y+ ++H++I+ FI A G G
Sbjct: 242 KGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGS 301
Query: 271 LLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIA 330
L+ + H GSL +L T D + L++A S A GL LH E + Q KP IA
Sbjct: 302 WTQ-LYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGT-QGKPAIA 359
Query: 331 HRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPE 390
HRDL S+N+LI+++GSC I DLGLA+ + T GT+RYMAPE
Sbjct: 360 HRDLKSKNILIKKNGSCCIADLGLAVKFN--------SDTNEVDVPLNTRVGTKRYMAPE 411
Query: 391 LLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTPTS 450
+LD++L+ + + ADIYS L++WE+ RC +QL Y + + P+
Sbjct: 412 VLDESLNKNHFQPYI-MADIYSFGLIIWEMARRC---ITGGIVEEYQLPYYNMVPSDPSY 467
Query: 451 DELWALAVQERRRPYIPSTW---RCFATDPDGLRELLEDCWDADPEARLTAECVQQRLAA 507
+++ + +R RP + + W C + +L+ +CW +P +RLTA +++ LA
Sbjct: 468 EDMREVVCVKRLRPIVSNRWNSDECLR----AVLKLMSECWAHNPASRLTALRIKKTLAK 523
Query: 508 LAHPQE 513
+ Q+
Sbjct: 524 MVESQD 529
>gi|116734714 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 147 bits (371), Expect = 3e-35
Identities = 138/492 (28%), Positives = 221/492 (44%), Gaps = 79/492 (16%)
Query: 61 CFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANY 120
C G W V +G + GC +LH + R P+ + C + CN N
Sbjct: 46 CRGAWCTV---VLVREEGRHPQEHRGCGNLHRELC-RGRPTEFVNHYCCD--SHLCNHNV 99
Query: 121 SHLPPPGSPGTPGSQGPQAAPGESIWMALVLLG-LFLLLLLLLGSIILALLQRKNYRVRG 179
S + +Q P PG +AL+L L LL L+ LG + L ++R+ + RG
Sbjct: 100 SLV-------LEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRG 152
Query: 180 --------------------------EPVPEPRPDSGRDWSVELQELPELCFSQVIREGG 213
+ SG + V+ ++ + + +G
Sbjct: 153 LHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGR 212
Query: 214 HAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITA---SRGGPGR 270
+ VW G G+ VA+K F R + E +Y L+HD+I+ FI + SR +
Sbjct: 213 YGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQ 272
Query: 271 LLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIA 330
L L+ H GSL +L + T + +LR+A+S A GLA LH E + Q KP IA
Sbjct: 273 LW----LITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGT-QGKPAIA 327
Query: 331 HRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAI-----MEAGTQR 385
HRD S+NVL++ + C I DLGLA++ QG + GT+R
Sbjct: 328 HRDFKSRNVLVKSNLQCCIADLGLAVM-------------HSQGSDYLDIGNNPRVGTKR 374
Query: 386 YMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSR--CPDLRPDSSPPPFQLAYEAE 443
YMAPE+LD+ + D + + DI++ L+LWEI R + D PP + +
Sbjct: 375 YMAPEVLDEQI-RTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDV----- 428
Query: 444 LGNTPTSDELWALAVQERRRPYIPSTWRCFATDP--DGLRELLEDCWDADPEARLTAECV 501
+ N P+ +++ + +++ P IP+ A DP GL +++ +CW +P ARLTA +
Sbjct: 429 VPNDPSFEDMKKVVCVDQQTPTIPNR---LAADPVLSGLAQMMRECWYPNPSARLTALRI 485
Query: 502 QQRLAALAHPQE 513
++ L +++ E
Sbjct: 486 KKTLQKISNSPE 497
>gi|116734712 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 147 bits (371), Expect = 3e-35
Identities = 138/492 (28%), Positives = 221/492 (44%), Gaps = 79/492 (16%)
Query: 61 CFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANY 120
C G W V +G + GC +LH + R P+ + C + CN N
Sbjct: 46 CRGAWCTV---VLVREEGRHPQEHRGCGNLHRELC-RGRPTEFVNHYCCD--SHLCNHNV 99
Query: 121 SHLPPPGSPGTPGSQGPQAAPGESIWMALVLLG-LFLLLLLLLGSIILALLQRKNYRVRG 179
S + +Q P PG +AL+L L LL L+ LG + L ++R+ + RG
Sbjct: 100 SLV-------LEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRG 152
Query: 180 --------------------------EPVPEPRPDSGRDWSVELQELPELCFSQVIREGG 213
+ SG + V+ ++ + + +G
Sbjct: 153 LHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGR 212
Query: 214 HAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITA---SRGGPGR 270
+ VW G G+ VA+K F R + E +Y L+HD+I+ FI + SR +
Sbjct: 213 YGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQ 272
Query: 271 LLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIA 330
L L+ H GSL +L + T + +LR+A+S A GLA LH E + Q KP IA
Sbjct: 273 LW----LITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGT-QGKPAIA 327
Query: 331 HRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAI-----MEAGTQR 385
HRD S+NVL++ + C I DLGLA++ QG + GT+R
Sbjct: 328 HRDFKSRNVLVKSNLQCCIADLGLAVM-------------HSQGSDYLDIGNNPRVGTKR 374
Query: 386 YMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSR--CPDLRPDSSPPPFQLAYEAE 443
YMAPE+LD+ + D + + DI++ L+LWEI R + D PP + +
Sbjct: 375 YMAPEVLDEQI-RTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDV----- 428
Query: 444 LGNTPTSDELWALAVQERRRPYIPSTWRCFATDP--DGLRELLEDCWDADPEARLTAECV 501
+ N P+ +++ + +++ P IP+ A DP GL +++ +CW +P ARLTA +
Sbjct: 429 VPNDPSFEDMKKVVCVDQQTPTIPNR---LAADPVLSGLAQMMRECWYPNPSARLTALRI 485
Query: 502 QQRLAALAHPQE 513
++ L +++ E
Sbjct: 486 KKTLQKISNSPE 497
>gi|33598912 activin A receptor, type IB isoform c precursor [Homo
sapiens]
Length = 487
Score = 145 bits (366), Expect = 1e-34
Identities = 107/336 (31%), Positives = 160/336 (47%), Gaps = 30/336 (8%)
Query: 108 TCSCGTDFCNANYSHLPPPG--SPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLG-- 163
T C TD+CN +P P P GP G +L + +++ L++
Sbjct: 93 THCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYH 152
Query: 164 ---------------SIILALLQRKNYRVRGEPVPEPRPDSGRDWSVELQELPELCFSQV 208
S + L + K + + SG V+ + ++
Sbjct: 153 QRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEI 212
Query: 209 IREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGP 268
I +G VW G+ +G VA+K F R + E +Y+ L+H++I+ FI A
Sbjct: 213 IGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDN 272
Query: 269 GRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPG 328
G LV + H GSL YL +YT +++ALS A GLA LH E Q KPG
Sbjct: 273 GTWTQ-LWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEI-VGTQGKPG 330
Query: 329 IAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMA 388
IAHRDL S+N+L++++G CAI DLGLA+ +T P Q GT+RYMA
Sbjct: 331 IAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQ--------RVGTKRYMA 382
Query: 389 PELLDKTLDLQDWGMALRRADIYSLALLLWEILSRC 424
PE+LD+T++++ + + + ADIY+L L+ WEI RC
Sbjct: 383 PEVLDETINMKHFD-SFKCADIYALGLVYWEIARRC 417
>gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens]
Length = 336
Score = 134 bits (337), Expect = 2e-31
Identities = 87/233 (37%), Positives = 133/233 (57%), Gaps = 16/233 (6%)
Query: 277 LVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDLSS 336
LV E H +GSL YL + +++ALS+A GLA LH E Q KP IAHRD+ S
Sbjct: 111 LVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEI-VGTQGKPAIAHRDIKS 169
Query: 337 QNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTL 396
+N+L+++ +CAI DLGLA+ + T PQ P + GT+RYMAPE+LD T+
Sbjct: 170 KNILVKKCETCAIADLGLAVKHDSILN----TIDIPQNP----KVGTKRYMAPEMLDDTM 221
Query: 397 DLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTPTSDELWAL 456
++ + + +RADIYS+ L+ WEI RC +QL Y + + P+ +E+ +
Sbjct: 222 NVNIF-ESFKRADIYSVGLVYWEIARRC---SVGGIVEEYQLPYYDMVPSDPSIEEMRKV 277
Query: 457 AVQERRRPYIPSTWR-CFATDPDGLRELLEDCWDADPEARLTAECVQQRLAAL 508
++ RP IP+ W+ C A G ++ +CW A+ ARLTA +++ ++ L
Sbjct: 278 VCDQKFRPSIPNQWQSCEALRVMG--RIMRECWYANGAARLTALRIKKTISQL 328
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 74.7 bits (182), Expect = 2e-13
Identities = 65/232 (28%), Positives = 105/232 (45%), Gaps = 38/232 (16%)
Query: 199 ELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRS------VAQFQAERALYELPGL 252
+L E+ F ++I G V+ G+ + K+VAIK + + V F E ++ L L
Sbjct: 459 QLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSI--LCQL 516
Query: 253 QHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTS--DWGSSLRMALSLAQ 310
H +++F+ A P + +V + GSL L + D S L +A+ +A+
Sbjct: 517 NHPCVIQFVGACLNDPSQFA----IVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAK 572
Query: 311 GLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPT 370
G+ +LH I HRDL+S N+L+ EDG + D G + L L +
Sbjct: 573 GMEYLHN-------LTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDE------- 618
Query: 371 QPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILS 422
+ G R+MAPE+ + +AD++S AL LWEIL+
Sbjct: 619 ----DNMTKQPGNLRWMAPEVFTQCT------RYTIKADVFSYALCLWEILT 660
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 74.7 bits (182), Expect = 2e-13
Identities = 65/232 (28%), Positives = 105/232 (45%), Gaps = 38/232 (16%)
Query: 199 ELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRS------VAQFQAERALYELPGL 252
+L E+ F ++I G V+ G+ + K+VAIK + + V F E ++ L L
Sbjct: 560 QLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSI--LCQL 617
Query: 253 QHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTS--DWGSSLRMALSLAQ 310
H +++F+ A P + +V + GSL L + D S L +A+ +A+
Sbjct: 618 NHPCVIQFVGACLNDPSQFA----IVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAK 673
Query: 311 GLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPT 370
G+ +LH I HRDL+S N+L+ EDG + D G + L L +
Sbjct: 674 GMEYLHN-------LTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDE------- 719
Query: 371 QPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILS 422
+ G R+MAPE+ + +AD++S AL LWEIL+
Sbjct: 720 ----DNMTKQPGNLRWMAPEVFTQCT------RYTIKADVFSYALCLWEILT 761
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 74.3 bits (181), Expect = 3e-13
Identities = 83/353 (23%), Positives = 151/353 (42%), Gaps = 75/353 (21%)
Query: 172 RKNYRVRGEPVPEP-RPDSGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKL-VAI 229
+ N+++ P+ +P P V + E + + EG VW G G L VAI
Sbjct: 198 KANWKLIQNPLLQPCMPQKAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAI 257
Query: 230 KAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCH 289
K ++ + + L GL+H+ ++R GG +V EL KG+L
Sbjct: 258 KVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGG-----EPVYIVTELMRKGNLQA 312
Query: 290 YLTQYTSDWGSSLRM------ALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIRE 343
+L + G +LR+ A +A+G+++L E+R + HRDL+++NVL+ +
Sbjct: 313 FLG---TPEGRALRLPPLLGFACQVAEGMSYLEEQR---------VVHRDLAARNVLVDD 360
Query: 344 DGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGM 403
+C + D GLA +L P+ + P ++ APE ++ +
Sbjct: 361 GLACKVADFGLARLLKDDIYSPSSSSKIP-----------VKWTAPE-------AANYRV 402
Query: 404 ALRRADIYSLALLLWEILS--RCPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQER 461
+++D++S +LL E+ + +CP YE + +Q+
Sbjct: 403 FSQKSDVWSFGVLLHEVFTYGQCP--------------YEGMTNHE---------TLQQI 439
Query: 462 RRPY-IPSTWRCFATDPDGLRELLEDCWDADPEARLTAECVQQRLAAL--AHP 511
R Y +P C P + L+ +CW + PE R + ++++L A+ HP
Sbjct: 440 MRGYRLPRPAAC----PAEVYVLMLECWRSSPEERPSFATLREKLHAIHRCHP 488
>gi|4885489 v-mos Moloney murine sarcoma viral oncogene homolog
[Homo sapiens]
Length = 346
Score = 73.2 bits (178), Expect = 6e-13
Identities = 69/242 (28%), Positives = 103/242 (42%), Gaps = 45/242 (18%)
Query: 202 ELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALY---ELPGLQHDHIV 258
++C Q + GG V+ +G VAIK + + + R+ + + L+HD+IV
Sbjct: 59 QVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELNVARLRHDNIV 118
Query: 259 RFITASRGGPGRLLSGPLLVLEL---------------HPKGSLC--HYLTQYTSDWGSS 301
R + AS P S +++E HP+G H T G
Sbjct: 119 RVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRTGGQLSLGKC 178
Query: 302 LRMALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGL 361
L+ +L + GL FLH + I H DL N+LI E C I D G + L L
Sbjct: 179 LKYSLDVVNGLLFLHSQ---------SIVHLDLKPANILISEQDVCKISDFGCSEKLEDL 229
Query: 362 TQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEIL 421
TP+ P G GT + APEL L+ G+ +ADIYS A+ LW++
Sbjct: 230 L--CFQTPSYPLG-------GTYTHRAPEL------LKGEGVT-PKADIYSFAITLWQMT 273
Query: 422 SR 423
++
Sbjct: 274 TK 275
>gi|62420875 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 70.9 bits (172), Expect = 3e-12
Identities = 62/233 (26%), Positives = 103/233 (44%), Gaps = 41/233 (17%)
Query: 199 ELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQ---HD 255
+ +L F + E +W G+ QG + +K R + ++ E P L+ H
Sbjct: 189 DFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHP 248
Query: 256 HIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYL---TQYTSDWGSSLRMALSLAQGL 312
+++ + A + P P L+ P GSL + L T + D +++ AL +A+G+
Sbjct: 249 NVLPVLGACQSPPA---PHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGM 305
Query: 313 AFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAI--GDLGLALVLPGLTQPPAWTPT 370
AFLH +P I L+S++V+I ED + I D+ + PG PAW
Sbjct: 306 AFLH-------TLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAW--- 355
Query: 371 QPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSR 423
+APE L K + R AD++S A+LLWE+++R
Sbjct: 356 ----------------VAPEALQKKPE----DTNRRSADMWSFAVLLWELVTR 388
>gi|62420873 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 70.9 bits (172), Expect = 3e-12
Identities = 62/233 (26%), Positives = 103/233 (44%), Gaps = 41/233 (17%)
Query: 199 ELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQ---HD 255
+ +L F + E +W G+ QG + +K R + ++ E P L+ H
Sbjct: 189 DFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHP 248
Query: 256 HIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYL---TQYTSDWGSSLRMALSLAQGL 312
+++ + A + P P L+ P GSL + L T + D +++ AL +A+G+
Sbjct: 249 NVLPVLGACQSPPA---PHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGM 305
Query: 313 AFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAI--GDLGLALVLPGLTQPPAWTPT 370
AFLH +P I L+S++V+I ED + I D+ + PG PAW
Sbjct: 306 AFLH-------TLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAW--- 355
Query: 371 QPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSR 423
+APE L K + R AD++S A+LLWE+++R
Sbjct: 356 ----------------VAPEALQKKPE----DTNRRSADMWSFAVLLWELVTR 388
>gi|4758606 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 70.9 bits (172), Expect = 3e-12
Identities = 62/233 (26%), Positives = 103/233 (44%), Gaps = 41/233 (17%)
Query: 199 ELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQ---HD 255
+ +L F + E +W G+ QG + +K R + ++ E P L+ H
Sbjct: 189 DFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHP 248
Query: 256 HIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYL---TQYTSDWGSSLRMALSLAQGL 312
+++ + A + P P L+ P GSL + L T + D +++ AL +A+G+
Sbjct: 249 NVLPVLGACQSPPA---PHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGM 305
Query: 313 AFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAI--GDLGLALVLPGLTQPPAWTPT 370
AFLH +P I L+S++V+I ED + I D+ + PG PAW
Sbjct: 306 AFLH-------TLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAW--- 355
Query: 371 QPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSR 423
+APE L K + R AD++S A+LLWE+++R
Sbjct: 356 ----------------VAPEALQKKPE----DTNRRSADMWSFAVLLWELVTR 388
>gi|187608615 tyrosine kinase 2 [Homo sapiens]
Length = 1187
Score = 70.5 bits (171), Expect = 4e-12
Identities = 70/278 (25%), Positives = 122/278 (43%), Gaps = 40/278 (14%)
Query: 224 GKLVAIKAFPPRSVAQFQA--ERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLEL 281
G++VA+KA Q ++ ++ + L L H+HI+++ + L LV+E
Sbjct: 924 GEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQ---LVMEY 980
Query: 282 HPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLI 341
P GSL YL +++ L A + +G+A+LH + + HRDL+++NVL+
Sbjct: 981 VPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHY---------IHRDLAARNVLL 1031
Query: 342 REDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDW 401
D IGD GLA +P + + + G + + + APE L +
Sbjct: 1032 DNDRLVKIGDFGLAKAVP---EGHEYYRVREDGDSPVF------WYAPECLKEY------ 1076
Query: 402 GMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQER 461
+D++S + L+E+L+ C DSS P E +G + L
Sbjct: 1077 -KFYYASDVWSFGVTLYELLTHC-----DSSQSPPTKFLEL-IGIAQGQMTVLRLTELLE 1129
Query: 462 RRPYIPSTWRCFATDPDGLRELLEDCWDADPEARLTAE 499
R +P +C P + L+++CW+ + R T E
Sbjct: 1130 RGERLPRPDKC----PCEVYHLMKNCWETEASFRPTFE 1163
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 70.1 bits (170), Expect = 5e-12
Identities = 104/384 (27%), Positives = 148/384 (38%), Gaps = 116/384 (30%)
Query: 176 RVRGEPVPEP-RPDSGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAF-- 232
R P P P RP S + E EL EL I GG V+ QG+ VA+KA
Sbjct: 101 RPAASPAPPPSRPSSPVHVAFERLELKEL-----IGAGGFGQVYRATWQGQEVAVKAARQ 155
Query: 233 PPRSVAQFQAERA--------------LYELPG--LQHDHIVRFITASRGG--------- 267
P A AE + EL G LQ H+ + +RGG
Sbjct: 156 DPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAA 215
Query: 268 ---PGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQ 324
P GP + P H L + A+ +A+G+ +LHEE +
Sbjct: 216 NAAPDPRAPGPRRARRIPP-----HVLVNW----------AVQIARGMLYLHEEAF---- 256
Query: 325 YKPGIAHRDLSSQNVLIRE----DGSC----AIGDLGLALVLPGLTQPPAWTPTQPQGPA 376
I HRDL S N+L+ E D C I D GLA W T
Sbjct: 257 --VPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLA---------REWHRT-----T 300
Query: 377 AIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPF 436
+ AGT +MAPE++ +L + +DI+S +LLWE+L+
Sbjct: 301 KMSTAGTYAWMAPEVIKSSL-------FSKGSDIWSYGVLLWELLTG------------- 340
Query: 437 QLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDGLRELLEDCWDADPEARL 496
++ Y G + +AV + P IPST P+ +L+++CW DP R
Sbjct: 341 EVPYRGIDGLAVA----YGVAVNKLTLP-IPSTC------PEPFAKLMKECWQQDPHIRP 389
Query: 497 TAECVQQRLAAL------AHPQES 514
+ + ++L A+ PQES
Sbjct: 390 SFALILEQLTAIEGAVMTEMPQES 413
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.452
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,366,874
Number of Sequences: 37866
Number of extensions: 1658856
Number of successful extensions: 16550
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 349
Number of HSP's successfully gapped in prelim test: 444
Number of HSP's that attempted gapping in prelim test: 7955
Number of HSP's gapped (non-prelim): 8156
length of query: 573
length of database: 18,247,518
effective HSP length: 108
effective length of query: 465
effective length of database: 14,157,990
effective search space: 6583465350
effective search space used: 6583465350
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.