Guide to the Human Genome
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Search of human proteins with 18641364

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|18641364 protein tyrosine phosphatase, receptor type, C
isoform 3 precursor [Homo sapiens]
         (1256 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|18641364 protein tyrosine phosphatase, receptor type, C isofo...  2575   0.0  
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo...  2552   0.0  
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo...  2290   0.0  
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo...   471   e-132
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor...   471   e-132
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo...   471   e-132
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor...   438   e-122
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo...   433   e-121
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...   397   e-110
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...   397   e-110
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...   397   e-110
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...   397   e-110
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...   397   e-110
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...   397   e-110
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...   396   e-110
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...   396   e-110
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...   396   e-110
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...   396   e-110
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...   396   e-110
gi|148539860 protein tyrosine phosphatase, receptor type, T isof...   356   9e-98
gi|148539858 protein tyrosine phosphatase, receptor type, T isof...   356   9e-98
gi|157419150 protein tyrosine phosphatase, receptor type, M isof...   347   5e-95
gi|157419152 protein tyrosine phosphatase, receptor type, M isof...   347   5e-95
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo...   337   4e-92
gi|208431815 protein tyrosine phosphatase, receptor type, K isof...   330   4e-90
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p...   322   1e-87
gi|110735404 protein tyrosine phosphatase, receptor type, U isof...   317   5e-86
gi|110735402 protein tyrosine phosphatase, receptor type, U isof...   317   5e-86
gi|194097398 protein tyrosine phosphatase, receptor type, G prec...   315   2e-85
gi|110735406 protein tyrosine phosphatase, receptor type, U isof...   310   4e-84

>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
            precursor [Homo sapiens]
          Length = 1256

 Score = 2575 bits (6673), Expect = 0.0
 Identities = 1256/1256 (100%), Positives = 1256/1256 (100%)

Query: 1    MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPAST 60
            MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPAST
Sbjct: 1    MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPAST 60

Query: 61   FERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGT 120
            FERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGT
Sbjct: 61   FERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGT 120

Query: 121  DTQTFSGSAANAKLNPTPGSNAISDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDE 180
            DTQTFSGSAANAKLNPTPGSNAISDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDE
Sbjct: 121  DTQTFSGSAANAKLNPTPGSNAISDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDE 180

Query: 181  KYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTA 240
            KYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTA
Sbjct: 181  KYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTA 240

Query: 241  PDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFD 300
            PDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFD
Sbjct: 241  PDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFD 300

Query: 301  NKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVI 360
            NKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVI
Sbjct: 301  NKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVI 360

Query: 361  TWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRN 420
            TWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRN
Sbjct: 361  TWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRN 420

Query: 421  GSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVR 480
            GSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVR
Sbjct: 421  GSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVR 480

Query: 481  NESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVT 540
            NESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVT
Sbjct: 481  NESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVT 540

Query: 541  SIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEG 600
            SIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEG
Sbjct: 541  SIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEG 600

Query: 601  RLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINA 660
            RLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINA
Sbjct: 601  RLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINA 660

Query: 661  SYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSME 720
            SYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSME
Sbjct: 661  SYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSME 720

Query: 721  EGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHL 780
            EGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHL
Sbjct: 721  EGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHL 780

Query: 781  LLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRR 840
            LLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRR
Sbjct: 781  LLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRR 840

Query: 841  QRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQR 900
            QRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQR
Sbjct: 841  QRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQR 900

Query: 901  LPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSD 960
            LPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSD
Sbjct: 901  LPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSD 960

Query: 961  SEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQE 1020
            SEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQE
Sbjct: 961  SEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQE 1020

Query: 1021 ICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQL 1080
            ICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQL
Sbjct: 1021 ICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQL 1080

Query: 1081 PAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAE 1140
            PAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAE
Sbjct: 1081 PAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAE 1140

Query: 1141 TEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDN 1200
            TEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDN
Sbjct: 1141 TEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDN 1200

Query: 1201 EVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS 1256
            EVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS
Sbjct: 1201 EVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS 1256


>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
            precursor [Homo sapiens]
          Length = 1304

 Score = 2552 bits (6614), Expect = 0.0
 Identities = 1256/1304 (96%), Positives = 1256/1304 (96%), Gaps = 48/1304 (3%)

Query: 1    MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPAST 60
            MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPAST
Sbjct: 1    MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPAST 60

Query: 61   FERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGT 120
            FERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGT
Sbjct: 61   FERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGT 120

Query: 121  DTQTFSGSAANAKLNPTPGSNAISD----------------------------------- 145
            DTQTFSGSAANAKLNPTPGSNAISD                                   
Sbjct: 121  DTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPA 180

Query: 146  -------------AYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYN 192
                         AYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYN
Sbjct: 181  RTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYN 240

Query: 193  KETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPG 252
            KETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPG
Sbjct: 241  KETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPG 300

Query: 253  VEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPE 312
            VEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPE
Sbjct: 301  VEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPE 360

Query: 313  HEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNF 372
            HEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNF
Sbjct: 361  HEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNF 420

Query: 373  TLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKS 432
            TLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKS
Sbjct: 421  TLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKS 480

Query: 433  APPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVK 492
            APPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVK
Sbjct: 481  APPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVK 540

Query: 493  DLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIY 552
            DLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIY
Sbjct: 541  DLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIY 600

Query: 553  DLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPR 612
            DLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPR
Sbjct: 601  DLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPR 660

Query: 613  VFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKY 672
            VFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKY
Sbjct: 661  VFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKY 720

Query: 673  IAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVK 732
            IAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVK
Sbjct: 721  IAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVK 780

Query: 733  INQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFS 792
            INQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFS
Sbjct: 781  INQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFS 840

Query: 793  NFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQY 852
            NFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQY
Sbjct: 841  NFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQY 900

Query: 853  ILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI 912
            ILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI
Sbjct: 901  ILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI 960

Query: 913  GNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASF 972
            GNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASF
Sbjct: 961  GNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASF 1020

Query: 973  IMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQT 1032
            IMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQT
Sbjct: 1021 IMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQT 1080

Query: 1033 YGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ 1092
            YGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ
Sbjct: 1081 YGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ 1140

Query: 1093 VVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVK 1152
            VVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVK
Sbjct: 1141 VVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVK 1200

Query: 1153 ALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCV 1212
            ALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCV
Sbjct: 1201 ALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCV 1260

Query: 1213 NPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS 1256
            NPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS
Sbjct: 1261 NPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS 1304


>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
            precursor [Homo sapiens]
          Length = 1143

 Score = 2290 bits (5935), Expect = 0.0
 Identities = 1115/1122 (99%), Positives = 1117/1122 (99%), Gaps = 3/1122 (0%)

Query: 135  NPTPGSNAISDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKE 194
            +PTP     +DAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKE
Sbjct: 25   SPTPSP---TDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKE 81

Query: 195  TKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVE 254
            TKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVE
Sbjct: 82   TKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVE 141

Query: 255  KFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHE 314
            KFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHE
Sbjct: 142  KFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHE 201

Query: 315  YKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTL 374
            YKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTL
Sbjct: 202  YKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTL 261

Query: 375  CYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAP 434
            CYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAP
Sbjct: 262  CYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAP 321

Query: 435  PSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDL 494
            PSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDL
Sbjct: 322  PSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDL 381

Query: 495  QYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDL 554
            QYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDL
Sbjct: 382  QYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDL 441

Query: 555  HKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVF 614
            HKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVF
Sbjct: 442  HKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVF 501

Query: 615  SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA 674
            SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA
Sbjct: 502  SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA 561

Query: 675  AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKIN 734
            AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKIN
Sbjct: 562  AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKIN 621

Query: 735  QHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF 794
            QHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF
Sbjct: 622  QHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF 681

Query: 795  FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYIL 854
            FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYIL
Sbjct: 682  FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYIL 741

Query: 855  IHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGN 914
            IHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGN
Sbjct: 742  IHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGN 801

Query: 915  QEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM 974
            QEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM
Sbjct: 802  QEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM 861

Query: 975  SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG 1034
            SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG
Sbjct: 862  SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG 921

Query: 1035 DIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVV 1094
            DIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVV
Sbjct: 922  DIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVV 981

Query: 1095 KQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKAL 1154
            KQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKAL
Sbjct: 982  KQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKAL 1041

Query: 1155 RKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNP 1214
            RKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNP
Sbjct: 1042 RKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNP 1101

Query: 1215 LGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS 1256
            LGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS
Sbjct: 1102 LGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS 1143



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 38/61 (62%), Positives = 45/61 (73%), Gaps = 3/61 (4%)

Query: 1  MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTG--LTTAKMPSV-PLSSDPLPTHTTAFSP 57
          MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPT   L  ++  ++ P  S  + T T A +P
Sbjct: 1  MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDAYLNASETTTLSPSGSAVISTTTIATTP 60

Query: 58 A 58
          +
Sbjct: 61 S 61


>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  471 bits (1212), Expect = e-132
 Identities = 267/668 (39%), Positives = 391/668 (58%), Gaps = 56/668 (8%)

Query: 529  LIAFLAFLIIVTSIALLVVL----YKIYDLHKKRSCNLDEQQELVERDDEKQLMN----- 579
            ++A  + L+IV  I +L +L    YK    H       + + E VE      L       
Sbjct: 147  MVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTN 206

Query: 580  --VEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDIL 637
                P+  D L E   R++AD+ +LF  EF ++P    +   + A K  N+ KNRYV+IL
Sbjct: 207  RKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNIL 266

Query: 638  PYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATV 697
            PYD++RV L+ + G   S+YINAS+I+G++E  K+IAAQGP++ETV+DFWRMIWEQ    
Sbjct: 267  PYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT 326

Query: 698  IVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKL------NIVN 751
            IVMVT  +E    KCA+YWP  ++G   +G++ V +       DY ++K       ++ N
Sbjct: 327  IVMVTNLKERKECKCAQYWP--DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 384

Query: 752  KKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTG 811
            +K +   R +T   FTSWPD GVP  P  +LK  ++V A +  ++G IVVHCSAGVGRTG
Sbjct: 385  RKPQ---RLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTG 441

Query: 812  TYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVN 871
            T++ IDAML+ +  E KVDVYG+V ++R QRC MVQ + QY+ I+QAL+E+  +G+TE+ 
Sbjct: 442  TFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELE 501

Query: 872  LSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ-HIGNQEENKSKNRNSNVIPY 930
            ++ L  +L  +  + P +  + LE EF++L S +    +   GN   N  KNR   +IPY
Sbjct: 502  VTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPY 561

Query: 931  DYNRV--PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGP 988
            ++NRV  P+K                       EE + Y+NASFI  Y + +  IA+QGP
Sbjct: 562  EFNRVIIPVKR---------------------GEENTDYVNASFIDGYRQKDSYIASQGP 600

Query: 989  LKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSS 1047
            L  TI DFW+MI++ K   IVMLTEL+   QE CAQYW  +G  +YGDI V+LK  ++  
Sbjct: 601  LLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECE 660

Query: 1048 TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 1107
            +YT+R   + +++   SR + Q+ +  W    +P++ K +IS+I  V     QK   +  
Sbjct: 661  SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV-----QKQQQQSG 715

Query: 1108 KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1167
             H    P+ +HC  G+ +TG FCAL  +LE  + E ++D+FQ VK+LR  RP MV T EQ
Sbjct: 716  NH----PITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771

Query: 1168 YQFLYDVI 1175
            Y+F Y V+
Sbjct: 772  YEFCYKVV 779



 Score =  197 bits (501), Expect = 5e-50
 Identities = 96/239 (40%), Positives = 146/239 (61%), Gaps = 4/239 (1%)

Query: 625 PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 684
           P N  KNR + I+PY++NRV +    G+  ++Y+NAS+IDG+++   YIA+QGP   T++
Sbjct: 547 PANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIE 606

Query: 685 DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 744
           DFWRMIWE K+  IVM+T  EE  + KCA+YWPS  +G  ++GD+ V++ + + C  Y +
Sbjct: 607 DFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVELKKEEECESYTV 664

Query: 745 QKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSG-PIVVHC 803
           + L + N +E  + R++    F  WP+ G+P D   ++ +   V          PI VHC
Sbjct: 665 RDLLVTNTRENKS-RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHC 723

Query: 804 SAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY 862
           SAG GRTGT+  +  +LE ++AE  +DV+  V  LR QR  MVQ   QY   ++ + EY
Sbjct: 724 SAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY 782



 Score =  160 bits (404), Expect = 9e-39
 Identities = 100/288 (34%), Positives = 146/288 (50%), Gaps = 34/288 (11%)

Query: 897  EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 956
            EF  LP+     T    ++EENK KNR  N++PYD++RV L        E   DSD    
Sbjct: 235  EFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLT-----PVEGVPDSD---- 285

Query: 957  DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 1016
                      YINASFI  Y +    IAAQGP +ET+ DFW+MI+++    IVM+T LK 
Sbjct: 286  ----------YINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKE 335

Query: 1017 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRH----SKRKDSRTVYQYQ 1071
              +  CAQYW  +G  TYG+I V ++D      YT+R F ++     + RK  R + Q+ 
Sbjct: 336  RKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFH 395

Query: 1072 YTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCA 1131
            +T+W    +P  P  ++  ++ VK   PQ   +          +++HC  G  +TG F  
Sbjct: 396  FTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGA----------IVVHCSAGVGRTGTFVV 445

Query: 1132 LLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1179
            +  +L+   TE  VD++  V  +R  R  MV T  QY F+Y  +   Y
Sbjct: 446  IDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY 493


>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
            precursor [Homo sapiens]
          Length = 802

 Score =  471 bits (1212), Expect = e-132
 Identities = 267/668 (39%), Positives = 391/668 (58%), Gaps = 56/668 (8%)

Query: 529  LIAFLAFLIIVTSIALLVVL----YKIYDLHKKRSCNLDEQQELVERDDEKQLMN----- 579
            ++A  + L+IV  I +L +L    YK    H       + + E VE      L       
Sbjct: 156  MVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTN 215

Query: 580  --VEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDIL 637
                P+  D L E   R++AD+ +LF  EF ++P    +   + A K  N+ KNRYV+IL
Sbjct: 216  RKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNIL 275

Query: 638  PYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATV 697
            PYD++RV L+ + G   S+YINAS+I+G++E  K+IAAQGP++ETV+DFWRMIWEQ    
Sbjct: 276  PYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT 335

Query: 698  IVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKL------NIVN 751
            IVMVT  +E    KCA+YWP  ++G   +G++ V +       DY ++K       ++ N
Sbjct: 336  IVMVTNLKERKECKCAQYWP--DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 393

Query: 752  KKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTG 811
            +K +   R +T   FTSWPD GVP  P  +LK  ++V A +  ++G IVVHCSAGVGRTG
Sbjct: 394  RKPQ---RLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTG 450

Query: 812  TYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVN 871
            T++ IDAML+ +  E KVDVYG+V ++R QRC MVQ + QY+ I+QAL+E+  +G+TE+ 
Sbjct: 451  TFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELE 510

Query: 872  LSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ-HIGNQEENKSKNRNSNVIPY 930
            ++ L  +L  +  + P +  + LE EF++L S +    +   GN   N  KNR   +IPY
Sbjct: 511  VTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPY 570

Query: 931  DYNRV--PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGP 988
            ++NRV  P+K                       EE + Y+NASFI  Y + +  IA+QGP
Sbjct: 571  EFNRVIIPVKR---------------------GEENTDYVNASFIDGYRQKDSYIASQGP 609

Query: 989  LKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSS 1047
            L  TI DFW+MI++ K   IVMLTEL+   QE CAQYW  +G  +YGDI V+LK  ++  
Sbjct: 610  LLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECE 669

Query: 1048 TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 1107
            +YT+R   + +++   SR + Q+ +  W    +P++ K +IS+I  V     QK   +  
Sbjct: 670  SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV-----QKQQQQSG 724

Query: 1108 KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1167
             H    P+ +HC  G+ +TG FCAL  +LE  + E ++D+FQ VK+LR  RP MV T EQ
Sbjct: 725  NH----PITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 780

Query: 1168 YQFLYDVI 1175
            Y+F Y V+
Sbjct: 781  YEFCYKVV 788



 Score =  197 bits (501), Expect = 5e-50
 Identities = 96/239 (40%), Positives = 146/239 (61%), Gaps = 4/239 (1%)

Query: 625 PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 684
           P N  KNR + I+PY++NRV +    G+  ++Y+NAS+IDG+++   YIA+QGP   T++
Sbjct: 556 PANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIE 615

Query: 685 DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 744
           DFWRMIWE K+  IVM+T  EE  + KCA+YWPS  +G  ++GD+ V++ + + C  Y +
Sbjct: 616 DFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVELKKEEECESYTV 673

Query: 745 QKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSG-PIVVHC 803
           + L + N +E  + R++    F  WP+ G+P D   ++ +   V          PI VHC
Sbjct: 674 RDLLVTNTRENKS-RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHC 732

Query: 804 SAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY 862
           SAG GRTGT+  +  +LE ++AE  +DV+  V  LR QR  MVQ   QY   ++ + EY
Sbjct: 733 SAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY 791



 Score =  160 bits (404), Expect = 9e-39
 Identities = 100/288 (34%), Positives = 146/288 (50%), Gaps = 34/288 (11%)

Query: 897  EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 956
            EF  LP+     T    ++EENK KNR  N++PYD++RV L        E   DSD    
Sbjct: 244  EFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLT-----PVEGVPDSD---- 294

Query: 957  DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 1016
                      YINASFI  Y +    IAAQGP +ET+ DFW+MI+++    IVM+T LK 
Sbjct: 295  ----------YINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKE 344

Query: 1017 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRH----SKRKDSRTVYQYQ 1071
              +  CAQYW  +G  TYG+I V ++D      YT+R F ++     + RK  R + Q+ 
Sbjct: 345  RKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFH 404

Query: 1072 YTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCA 1131
            +T+W    +P  P  ++  ++ VK   PQ   +          +++HC  G  +TG F  
Sbjct: 405  FTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGA----------IVVHCSAGVGRTGTFVV 454

Query: 1132 LLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1179
            +  +L+   TE  VD++  V  +R  R  MV T  QY F+Y  +   Y
Sbjct: 455  IDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY 502


>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  471 bits (1212), Expect = e-132
 Identities = 267/668 (39%), Positives = 391/668 (58%), Gaps = 56/668 (8%)

Query: 529  LIAFLAFLIIVTSIALLVVL----YKIYDLHKKRSCNLDEQQELVERDDEKQLMN----- 579
            ++A  + L+IV  I +L +L    YK    H       + + E VE      L       
Sbjct: 147  MVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTN 206

Query: 580  --VEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDIL 637
                P+  D L E   R++AD+ +LF  EF ++P    +   + A K  N+ KNRYV+IL
Sbjct: 207  RKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNIL 266

Query: 638  PYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATV 697
            PYD++RV L+ + G   S+YINAS+I+G++E  K+IAAQGP++ETV+DFWRMIWEQ    
Sbjct: 267  PYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT 326

Query: 698  IVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKL------NIVN 751
            IVMVT  +E    KCA+YWP  ++G   +G++ V +       DY ++K       ++ N
Sbjct: 327  IVMVTNLKERKECKCAQYWP--DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 384

Query: 752  KKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTG 811
            +K +   R +T   FTSWPD GVP  P  +LK  ++V A +  ++G IVVHCSAGVGRTG
Sbjct: 385  RKPQ---RLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTG 441

Query: 812  TYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVN 871
            T++ IDAML+ +  E KVDVYG+V ++R QRC MVQ + QY+ I+QAL+E+  +G+TE+ 
Sbjct: 442  TFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELE 501

Query: 872  LSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ-HIGNQEENKSKNRNSNVIPY 930
            ++ L  +L  +  + P +  + LE EF++L S +    +   GN   N  KNR   +IPY
Sbjct: 502  VTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPY 561

Query: 931  DYNRV--PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGP 988
            ++NRV  P+K                       EE + Y+NASFI  Y + +  IA+QGP
Sbjct: 562  EFNRVIIPVKR---------------------GEENTDYVNASFIDGYRQKDSYIASQGP 600

Query: 989  LKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSS 1047
            L  TI DFW+MI++ K   IVMLTEL+   QE CAQYW  +G  +YGDI V+LK  ++  
Sbjct: 601  LLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECE 660

Query: 1048 TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 1107
            +YT+R   + +++   SR + Q+ +  W    +P++ K +IS+I  V     QK   +  
Sbjct: 661  SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV-----QKQQQQSG 715

Query: 1108 KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1167
             H    P+ +HC  G+ +TG FCAL  +LE  + E ++D+FQ VK+LR  RP MV T EQ
Sbjct: 716  NH----PITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771

Query: 1168 YQFLYDVI 1175
            Y+F Y V+
Sbjct: 772  YEFCYKVV 779



 Score =  197 bits (501), Expect = 5e-50
 Identities = 96/239 (40%), Positives = 146/239 (61%), Gaps = 4/239 (1%)

Query: 625 PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 684
           P N  KNR + I+PY++NRV +    G+  ++Y+NAS+IDG+++   YIA+QGP   T++
Sbjct: 547 PANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIE 606

Query: 685 DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 744
           DFWRMIWE K+  IVM+T  EE  + KCA+YWPS  +G  ++GD+ V++ + + C  Y +
Sbjct: 607 DFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVELKKEEECESYTV 664

Query: 745 QKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSG-PIVVHC 803
           + L + N +E  + R++    F  WP+ G+P D   ++ +   V          PI VHC
Sbjct: 665 RDLLVTNTRENKS-RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHC 723

Query: 804 SAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY 862
           SAG GRTGT+  +  +LE ++AE  +DV+  V  LR QR  MVQ   QY   ++ + EY
Sbjct: 724 SAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY 782



 Score =  160 bits (404), Expect = 9e-39
 Identities = 100/288 (34%), Positives = 146/288 (50%), Gaps = 34/288 (11%)

Query: 897  EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 956
            EF  LP+     T    ++EENK KNR  N++PYD++RV L        E   DSD    
Sbjct: 235  EFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLT-----PVEGVPDSD---- 285

Query: 957  DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 1016
                      YINASFI  Y +    IAAQGP +ET+ DFW+MI+++    IVM+T LK 
Sbjct: 286  ----------YINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKE 335

Query: 1017 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRH----SKRKDSRTVYQYQ 1071
              +  CAQYW  +G  TYG+I V ++D      YT+R F ++     + RK  R + Q+ 
Sbjct: 336  RKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFH 395

Query: 1072 YTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCA 1131
            +T+W    +P  P  ++  ++ VK   PQ   +          +++HC  G  +TG F  
Sbjct: 396  FTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGA----------IVVHCSAGVGRTGTFVV 445

Query: 1132 LLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1179
            +  +L+   TE  VD++  V  +R  R  MV T  QY F+Y  +   Y
Sbjct: 446  IDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY 493


>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
            precursor [Homo sapiens]
          Length = 700

 Score =  438 bits (1126), Expect = e-122
 Identities = 257/674 (38%), Positives = 383/674 (56%), Gaps = 55/674 (8%)

Query: 526  SKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQE-----LVERDDEKQLMNV 580
            S+ L+A+L   +++  + LL+  Y  +   K+R   +    +     ++E  +++++M +
Sbjct: 44   SQPLLAWLLLPLLLLLLVLLLAAY-FFRFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLL 102

Query: 581  E----------PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNK 630
                       PI  + L E  + + AD+ + F  EF S+P    +   + A K  N+ K
Sbjct: 103  SRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREK 162

Query: 631  NRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMI 690
            NRY +ILP D++RV LS+++G   S+YINASYIDG+KE  K+IAAQGP+ ETV+DFWRM+
Sbjct: 163  NRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMV 222

Query: 691  WEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIV 750
            WEQK+  IVM+T  +E    KC +YWP  ++G   +G++ V +       DY I+K  I 
Sbjct: 223  WEQKSATIVMLTNLKERKEEKCHQYWP--DQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ 280

Query: 751  NKKEKA--TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVG 808
             +        R V+ + FTSWPD GVP  P  +LK  ++V   +   +GPIVVHCSAGVG
Sbjct: 281  PQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVG 340

Query: 809  RTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGET 868
            RTGT+I IDAM+  + AE KVDV+ +V ++R QR  MVQ + QY  I+QAL+EY  +G+T
Sbjct: 341  RTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDT 400

Query: 869  EVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWR-TQHIGNQEENKSKNRNSNV 927
            E+++S L  +L  M       +   LE EF++L + R  +     GN   N  K R   +
Sbjct: 401  ELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQI 460

Query: 928  IPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQG 987
            IPYD+NRV L  +                     +E + YINASFI  Y + +  IA QG
Sbjct: 461  IPYDFNRVILSMK-------------------RGQEYTDYINASFIDGYRQKDYFIATQG 501

Query: 988  PLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKS 1046
            PL  T+ DFW+MI++ K   IVMLTE++  +Q+ C QYW  EG  T+G+I +++K+   S
Sbjct: 502  PLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLS 561

Query: 1047 STYTLRVF-----ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQK 1101
               ++R F     + +  + +  R V Q+ +  W    +PAE K +I +I  V     QK
Sbjct: 562  EAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAV-----QK 616

Query: 1102 NSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGM 1161
               +   H    P+ +HC  G+ +TG F AL N+LE  + E ++D+FQ VK+LR  RP M
Sbjct: 617  QQQQTGNH----PITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHM 672

Query: 1162 VSTFEQYQFLYDVI 1175
            V T EQY+F Y V+
Sbjct: 673  VQTLEQYEFCYKVV 686



 Score =  173 bits (439), Expect = 8e-43
 Identities = 98/264 (37%), Positives = 148/264 (56%), Gaps = 10/264 (3%)

Query: 606 EFQSIPRV-FSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYID 664
           EF+ +  V   K  ++    P N  K R + I+PYD+NRV LS   G   ++YINAS+ID
Sbjct: 429 EFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFID 488

Query: 665 GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTR 724
           G+++   +IA QGP   TV+DFWRMIWE K+  IVM+T  +E  ++KC +YWP+  EG+ 
Sbjct: 489 GYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPT--EGSV 546

Query: 725 AFGDVVVKINQHKRCP-----DYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPH 779
             G++ ++I            D+++  LN    +++   R V    F  WP+ G+P +  
Sbjct: 547 THGEITIEIKNDTLSEAISIRDFLVT-LNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGK 605

Query: 780 LLLKLRRRVNAFSNFFSG-PIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKL 838
            ++ L   V          PI VHCSAG GRTGT+I +  +LE ++AE  +DV+  V  L
Sbjct: 606 GMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 665

Query: 839 RRQRCLMVQVEAQYILIHQALVEY 862
           R QR  MVQ   QY   ++ + ++
Sbjct: 666 RLQRPHMVQTLEQYEFCYKVVQDF 689



 Score =  158 bits (399), Expect = 4e-38
 Identities = 100/287 (34%), Positives = 146/287 (50%), Gaps = 33/287 (11%)

Query: 897  EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 956
            EF  LPS     T  + N+EEN+ KNR  N++P D++RV L         S+ D    SD
Sbjct: 138  EFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVIL---------SQLDGIPCSD 188

Query: 957  DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 1016
                      YINAS+I  Y +    IAAQGP +ET+ DFW+M++++K   IVMLT LK 
Sbjct: 189  ----------YINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKE 238

Query: 1017 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKR---KDSRTVYQYQY 1072
              +E C QYW  +G  TYG+I V ++D      YT+R F ++       K  R V Q  +
Sbjct: 239  RKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHF 298

Query: 1073 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1132
            T+W    +P  P  ++  ++ VK   P            + P+++HC  G  +TG F  +
Sbjct: 299  TSWPDFGVPFTPIGMLKFLKKVKTLNPVH----------AGPIVVHCSAGVGRTGTFIVI 348

Query: 1133 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1179
              ++     E+ VD+F+ V  +R  RP MV T  QY F+Y  +   Y
Sbjct: 349  DAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY 395


>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
            [Homo sapiens]
          Length = 642

 Score =  433 bits (1113), Expect = e-121
 Identities = 246/603 (40%), Positives = 352/603 (58%), Gaps = 39/603 (6%)

Query: 582  PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 641
            PI  + L E  + + AD+ + F  EF S+P    +   + A K  N+ KNRY +ILP D+
Sbjct: 56   PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDH 115

Query: 642  NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 701
            +RV LS+++G   S+YINASYIDG+KE  K+IAAQGP+ ETV+DFWRM+WEQK+  IVM+
Sbjct: 116  SRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML 175

Query: 702  TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA--TGR 759
            T  +E    KC +YWP  ++G   +G++ V +       DY I+K  I  +        R
Sbjct: 176  TNLKERKEEKCHQYWP--DQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPR 233

Query: 760  EVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAM 819
             V+ + FTSWPD GVP  P  +LK  ++V   +   +GPIVVHCSAGVGRTGT+I IDAM
Sbjct: 234  LVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAM 293

Query: 820  LEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYL 879
            +  + AE KVDV+ +V ++R QR  MVQ + QY  I+QAL+EY  +G+TE+++S L  +L
Sbjct: 294  MAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHL 353

Query: 880  HNMKKRDPPSEPSPLEAEFQRLPSYRSWR-TQHIGNQEENKSKNRNSNVIPYDYNRVPLK 938
              M       +   LE EF++L + R  +     GN   N  K R   +IPYD+NRV L 
Sbjct: 354  QTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILS 413

Query: 939  HELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQ 998
             +                     +E + YINASFI  Y + +  IA QGPL  T+ DFW+
Sbjct: 414  MK-------------------RGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWR 454

Query: 999  MIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF--- 1054
            MI++ K   IVMLTE++  +Q+ C QYW  EG  T+G+I +++K+   S   ++R F   
Sbjct: 455  MIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVT 514

Query: 1055 --ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKS 1112
              + +  + +  R V Q+ +  W    +PAE K +I +I  V     QK   +   H   
Sbjct: 515  LNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAV-----QKQQQQTGNH--- 566

Query: 1113 TPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
             P+ +HC  G+ +TG F AL N+LE  + E ++D+FQ VK+LR  RP MV T EQY+F Y
Sbjct: 567  -PITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCY 625

Query: 1173 DVI 1175
             V+
Sbjct: 626  KVV 628



 Score =  173 bits (439), Expect = 8e-43
 Identities = 98/264 (37%), Positives = 148/264 (56%), Gaps = 10/264 (3%)

Query: 606 EFQSIPRV-FSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYID 664
           EF+ +  V   K  ++    P N  K R + I+PYD+NRV LS   G   ++YINAS+ID
Sbjct: 371 EFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFID 430

Query: 665 GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTR 724
           G+++   +IA QGP   TV+DFWRMIWE K+  IVM+T  +E  ++KC +YWP+  EG+ 
Sbjct: 431 GYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPT--EGSV 488

Query: 725 AFGDVVVKINQHKRCP-----DYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPH 779
             G++ ++I            D+++  LN    +++   R V    F  WP+ G+P +  
Sbjct: 489 THGEITIEIKNDTLSEAISIRDFLVT-LNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGK 547

Query: 780 LLLKLRRRVNAFSNFFSG-PIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKL 838
            ++ L   V          PI VHCSAG GRTGT+I +  +LE ++AE  +DV+  V  L
Sbjct: 548 GMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 607

Query: 839 RRQRCLMVQVEAQYILIHQALVEY 862
           R QR  MVQ   QY   ++ + ++
Sbjct: 608 RLQRPHMVQTLEQYEFCYKVVQDF 631



 Score =  158 bits (399), Expect = 4e-38
 Identities = 100/287 (34%), Positives = 146/287 (50%), Gaps = 33/287 (11%)

Query: 897  EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 956
            EF  LPS     T  + N+EEN+ KNR  N++P D++RV L         S+ D    SD
Sbjct: 80   EFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVIL---------SQLDGIPCSD 130

Query: 957  DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 1016
                      YINAS+I  Y +    IAAQGP +ET+ DFW+M++++K   IVMLT LK 
Sbjct: 131  ----------YINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKE 180

Query: 1017 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKR---KDSRTVYQYQY 1072
              +E C QYW  +G  TYG+I V ++D      YT+R F ++       K  R V Q  +
Sbjct: 181  RKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHF 240

Query: 1073 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1132
            T+W    +P  P  ++  ++ VK   P            + P+++HC  G  +TG F  +
Sbjct: 241  TSWPDFGVPFTPIGMLKFLKKVKTLNPVH----------AGPIVVHCSAGVGRTGTFIVI 290

Query: 1133 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1179
              ++     E+ VD+F+ V  +R  RP MV T  QY F+Y  +   Y
Sbjct: 291  DAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY 337


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score =  397 bits (1020), Expect = e-110
 Identities = 235/600 (39%), Positives = 334/600 (55%), Gaps = 33/600 (5%)

Query: 575  KQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYV 634
            + +++  PI    + E  +R  A++      E++SI     +F  + +    N+ KNRY 
Sbjct: 1365 ESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYA 1423

Query: 635  DILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQK 694
            +++ YD++RV L  I G  GS+YINA+Y+DG++    YIA QGP  ET  DFWRM+WEQ+
Sbjct: 1424 NVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQR 1483

Query: 695  ATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKE 754
            +  IVM+TR EE +R KC +YWP+   GT  +G + V +        + ++  ++ +K  
Sbjct: 1484 SATIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNG 1540

Query: 755  KATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYI 814
             +  REV   QFT+WPDHGVPE P   L   RRV   +   +GPIVVHCSAGVGRTG +I
Sbjct: 1541 SSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFI 1600

Query: 815  GIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSE 874
             IDAMLE ++ E  VDVYG+V  +R QR  MVQ E QY  IH+AL+E    G TEV    
Sbjct: 1601 VIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARS 1660

Query: 875  LHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYN 933
            L+ Y+  + + +P    + +E EF+RL + ++  ++ I  N   NK KNR  N++PY+  
Sbjct: 1661 LYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYEST 1720

Query: 934  RVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETI 993
            RV L+                        E S YINASFI  Y + +  IA QGPL ET 
Sbjct: 1721 RVCLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1761

Query: 994  GDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLR 1052
             DFW+M+++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR
Sbjct: 1762 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1821

Query: 1053 VFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKS 1112
             F++  ++   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G      
Sbjct: 1822 EFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG------ 1874

Query: 1113 TPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
             P+ +HC  G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T ++YQF Y
Sbjct: 1875 -PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1933



 Score =  198 bits (503), Expect = 3e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 1700 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1759

Query: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 1760 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1817

Query: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 1818 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1876

Query: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E +Y   +QA 
Sbjct: 1877 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1936

Query: 860  VEY 862
            +EY
Sbjct: 1937 LEY 1939



 Score =  155 bits (392), Expect = 2e-37
 Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)

Query: 894  LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 953
            L  E++ +   + +  +H  N E NK KNR +NVI YD++RV L+               
Sbjct: 1393 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 1436

Query: 954  SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 1013
                  +    S YINA+++  Y      IA QGPL ET GDFW+M+++++   IVM+T 
Sbjct: 1437 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1492

Query: 1014 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 1072
            L+   +  C QYW   G +TYG I+V L DT + +T+ +R F L  +   + R V Q+Q+
Sbjct: 1493 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1552

Query: 1073 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1132
            T W    +P  P   ++ ++ VK   P            + P+++HC  G  +TG F  +
Sbjct: 1553 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1602

Query: 1133 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1186
              +LE  + E+ VD++  V  +R  R  MV T +QY F+++ +       N +V
Sbjct: 1603 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1656



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 33/133 (24%), Positives = 58/133 (43%), Gaps = 17/133 (12%)

Query: 335 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 392
           +KT  G PG+P  +   + +     ++W+PP Q S   + L + + +  ++         
Sbjct: 518 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 577

Query: 393 KYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-------SAPPSQVWNMTVSM 445
            Y +++LKP T+Y     A+ +A     G  A      +       SAPP  V  ++V  
Sbjct: 578 SYVVEDLKPNTEY-----AFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRS 632

Query: 446 TSDNSMHVKCRPP 458
           T   ++ V  RPP
Sbjct: 633 T---AILVSWRPP 642


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score =  397 bits (1020), Expect = e-110
 Identities = 240/656 (36%), Positives = 356/656 (54%), Gaps = 50/656 (7%)

Query: 536  LIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDD---------EKQLMNVE----- 581
            ++ V  I L+V+   ++   +  S +  ++Q +  +D          E + +N +     
Sbjct: 1268 VLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1327

Query: 582  ---PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP 638
               PI    L +  +R  A++G  F  E++SI     +F  + +    N+ KNRY +++ 
Sbjct: 1328 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPG-QQFTWENSNLEVNKPKNRYANVIA 1386

Query: 639  YDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVI 698
            YD++RV L+ I+G  GS+YINA+YIDG+++   YIA QGP  ET+ DFWRM+WEQ+   +
Sbjct: 1387 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1446

Query: 699  VMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG 758
            VM+TR EE +R KC +YWP+   GT   G + V +        Y ++   + +K   +  
Sbjct: 1447 VMMTRLEEKSRVKCDQYWPA--RGTETCGLIQVTLLDTVELATYTVRTFAL-HKSGSSEK 1503

Query: 759  REVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDA 818
            RE+   QF +WPDHGVPE P  +L   RRV A +   +GP+VVHCSAGVGRTG +I IDA
Sbjct: 1504 RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDA 1563

Query: 819  MLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPY 878
            MLE ++ E  VD+YG+V  +R QR  MVQ E QY+ IH+AL+E    G TEV    L+ +
Sbjct: 1564 MLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH 1623

Query: 879  LHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPL 937
            +  + +  P    + +E EF+ L S ++  ++ I  N   NK KNR  N++PY+  RV L
Sbjct: 1624 IQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCL 1683

Query: 938  KHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFW 997
            +                        E S YINASF+  Y + +  IA QGPL E+  DFW
Sbjct: 1684 Q-------------------PIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFW 1724

Query: 998  QMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFEL 1056
            +M+++    +IVMLT+L+   +E C QYW  E    Y    VD         Y LR F++
Sbjct: 1725 RMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV 1784

Query: 1057 RHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1116
              ++   SRT+ Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ 
Sbjct: 1785 TDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQV-HKTKEQFGQDG-------PIT 1836

Query: 1117 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
            +HC  G  +TG+F  L  +LE    E VVD+FQ VK LR  RP MV T +QYQ  Y
Sbjct: 1837 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY 1892



 Score =  197 bits (500), Expect = 7e-50
 Identities = 102/243 (41%), Positives = 146/243 (60%), Gaps = 5/243 (2%)

Query: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS++DG+++ + YIA QGP  E
Sbjct: 1659 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1718

Query: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
            + +DFWRM+WE  +T+IVM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 1719 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1776

Query: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799
            YI+++  + + ++    R +   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 1777 YILREFKVTDARD-GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPI 1835

Query: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY L ++A 
Sbjct: 1836 TVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAA 1895

Query: 860  VEY 862
            +EY
Sbjct: 1896 LEY 1898



 Score =  156 bits (395), Expect = 1e-37
 Identities = 93/278 (33%), Positives = 142/278 (51%), Gaps = 30/278 (10%)

Query: 914  NQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFI 973
            N E NK KNR +NVI YD++RV L                      D    S YINA++I
Sbjct: 1371 NLEVNKPKNRYANVIAYDHSRVILT-------------------SIDGVPGSDYINANYI 1411

Query: 974  MSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQT 1032
              Y K    IA QGPL ET+GDFW+M+++++   +VM+T L+   +  C QYW   G +T
Sbjct: 1412 DGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTET 1471

Query: 1033 YGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ 1092
             G I+V L DT + +TYT+R F L  S   + R + Q+Q+  W    +P  P  +++ ++
Sbjct: 1472 CGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLR 1531

Query: 1093 VVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVK 1152
             VK   P            + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V 
Sbjct: 1532 RVKACNPLD----------AGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVT 1581

Query: 1153 ALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNN 1190
             +R  R  MV T +QY F+++ +       + +V   N
Sbjct: 1582 CMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARN 1619


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score =  397 bits (1020), Expect = e-110
 Identities = 240/656 (36%), Positives = 356/656 (54%), Gaps = 50/656 (7%)

Query: 536  LIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDD---------EKQLMNVE----- 581
            ++ V  I L+V+   ++   +  S +  ++Q +  +D          E + +N +     
Sbjct: 1259 VLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1318

Query: 582  ---PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP 638
               PI    L +  +R  A++G  F  E++SI     +F  + +    N+ KNRY +++ 
Sbjct: 1319 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPG-QQFTWENSNLEVNKPKNRYANVIA 1377

Query: 639  YDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVI 698
            YD++RV L+ I+G  GS+YINA+YIDG+++   YIA QGP  ET+ DFWRM+WEQ+   +
Sbjct: 1378 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1437

Query: 699  VMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG 758
            VM+TR EE +R KC +YWP+   GT   G + V +        Y ++   + +K   +  
Sbjct: 1438 VMMTRLEEKSRVKCDQYWPA--RGTETCGLIQVTLLDTVELATYTVRTFAL-HKSGSSEK 1494

Query: 759  REVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDA 818
            RE+   QF +WPDHGVPE P  +L   RRV A +   +GP+VVHCSAGVGRTG +I IDA
Sbjct: 1495 RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDA 1554

Query: 819  MLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPY 878
            MLE ++ E  VD+YG+V  +R QR  MVQ E QY+ IH+AL+E    G TEV    L+ +
Sbjct: 1555 MLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAH 1614

Query: 879  LHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPL 937
            +  + +  P    + +E EF+ L S ++  ++ I  N   NK KNR  N++PY+  RV L
Sbjct: 1615 IQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCL 1674

Query: 938  KHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFW 997
            +                        E S YINASF+  Y + +  IA QGPL E+  DFW
Sbjct: 1675 Q-------------------PIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFW 1715

Query: 998  QMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFEL 1056
            +M+++    +IVMLT+L+   +E C QYW  E    Y    VD         Y LR F++
Sbjct: 1716 RMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKV 1775

Query: 1057 RHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1116
              ++   SRT+ Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ 
Sbjct: 1776 TDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQV-HKTKEQFGQDG-------PIT 1827

Query: 1117 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
            +HC  G  +TG+F  L  +LE    E VVD+FQ VK LR  RP MV T +QYQ  Y
Sbjct: 1828 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY 1883



 Score =  197 bits (500), Expect = 7e-50
 Identities = 102/243 (41%), Positives = 146/243 (60%), Gaps = 5/243 (2%)

Query: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS++DG+++ + YIA QGP  E
Sbjct: 1650 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1709

Query: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
            + +DFWRM+WE  +T+IVM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 1710 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1767

Query: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799
            YI+++  + + ++    R +   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 1768 YILREFKVTDARD-GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPI 1826

Query: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY L ++A 
Sbjct: 1827 TVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAA 1886

Query: 860  VEY 862
            +EY
Sbjct: 1887 LEY 1889



 Score =  156 bits (395), Expect = 1e-37
 Identities = 93/278 (33%), Positives = 142/278 (51%), Gaps = 30/278 (10%)

Query: 914  NQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFI 973
            N E NK KNR +NVI YD++RV L                      D    S YINA++I
Sbjct: 1362 NLEVNKPKNRYANVIAYDHSRVILT-------------------SIDGVPGSDYINANYI 1402

Query: 974  MSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQT 1032
              Y K    IA QGPL ET+GDFW+M+++++   +VM+T L+   +  C QYW   G +T
Sbjct: 1403 DGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTET 1462

Query: 1033 YGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ 1092
             G I+V L DT + +TYT+R F L  S   + R + Q+Q+  W    +P  P  +++ ++
Sbjct: 1463 CGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLR 1522

Query: 1093 VVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVK 1152
             VK   P            + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V 
Sbjct: 1523 RVKACNPLD----------AGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVT 1572

Query: 1153 ALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNN 1190
             +R  R  MV T +QY F+++ +       + +V   N
Sbjct: 1573 CMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARN 1610


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score =  397 bits (1019), Expect = e-110
 Identities = 235/598 (39%), Positives = 333/598 (55%), Gaps = 33/598 (5%)

Query: 577  LMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDI 636
            +++  PI    + E  +R  A++      E++SI     +F  + +    N+ KNRY ++
Sbjct: 924  MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANV 982

Query: 637  LPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKAT 696
            + YD++RV L  I G  GS+YINA+Y+DG++    YIA QGP  ET  DFWRM+WEQ++ 
Sbjct: 983  IAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSA 1042

Query: 697  VIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA 756
             IVM+TR EE +R KC +YWP+   GT  +G + V +        + ++  ++ +K   +
Sbjct: 1043 TIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNGSS 1099

Query: 757  TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGI 816
              REV   QFT+WPDHGVPE P   L   RRV   +   +GPIVVHCSAGVGRTG +I I
Sbjct: 1100 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1159

Query: 817  DAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELH 876
            DAMLE ++ E  VDVYG+V  +R QR  MVQ E QY  IH+AL+E    G TEV    L+
Sbjct: 1160 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1219

Query: 877  PYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRV 935
             Y+  + + +P    + +E EF+RL + ++  ++ I  N   NK KNR  N++PY+  RV
Sbjct: 1220 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1279

Query: 936  PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGD 995
             L+                        E S YINASFI  Y + +  IA QGPL ET  D
Sbjct: 1280 CLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1320

Query: 996  FWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF 1054
            FW+M+++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR F
Sbjct: 1321 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1380

Query: 1055 ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTP 1114
            ++  ++   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P
Sbjct: 1381 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------P 1432

Query: 1115 LLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
            + +HC  G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T ++YQF Y
Sbjct: 1433 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1490



 Score =  198 bits (503), Expect = 3e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 1257 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1316

Query: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 1317 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1374

Query: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 1375 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1433

Query: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E +Y   +QA 
Sbjct: 1434 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1493

Query: 860  VEY 862
            +EY
Sbjct: 1494 LEY 1496



 Score =  155 bits (392), Expect = 2e-37
 Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)

Query: 894  LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 953
            L  E++ +   + +  +H  N E NK KNR +NVI YD++RV L+               
Sbjct: 950  LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 993

Query: 954  SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 1013
                  +    S YINA+++  Y      IA QGPL ET GDFW+M+++++   IVM+T 
Sbjct: 994  ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1049

Query: 1014 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 1072
            L+   +  C QYW   G +TYG I+V L DT + +T+ +R F L  +   + R V Q+Q+
Sbjct: 1050 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1109

Query: 1073 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1132
            T W    +P  P   ++ ++ VK   P            + P+++HC  G  +TG F  +
Sbjct: 1110 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1159

Query: 1133 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1186
              +LE  + E+ VD++  V  +R  R  MV T +QY F+++ +       N +V
Sbjct: 1160 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1213



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 20/79 (25%), Positives = 38/79 (48%), Gaps = 2/79 (2%)

Query: 335 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 392
           +KT  G PG+P  +   + +     ++W+PP Q S   + L + + +  ++         
Sbjct: 509 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 568

Query: 393 KYDLQNLKPYTKYVLSLHA 411
            Y +++LKP T+Y   L A
Sbjct: 569 SYVVEDLKPNTEYAFRLAA 587


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score =  397 bits (1019), Expect = e-110
 Identities = 235/598 (39%), Positives = 333/598 (55%), Gaps = 33/598 (5%)

Query: 577  LMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDI 636
            +++  PI    + E  +R  A++      E++SI     +F  + +    N+ KNRY ++
Sbjct: 1329 MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANV 1387

Query: 637  LPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKAT 696
            + YD++RV L  I G  GS+YINA+Y+DG++    YIA QGP  ET  DFWRM+WEQ++ 
Sbjct: 1388 IAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSA 1447

Query: 697  VIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA 756
             IVM+TR EE +R KC +YWP+   GT  +G + V +        + ++  ++ +K   +
Sbjct: 1448 TIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNGSS 1504

Query: 757  TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGI 816
              REV   QFT+WPDHGVPE P   L   RRV   +   +GPIVVHCSAGVGRTG +I I
Sbjct: 1505 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1564

Query: 817  DAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELH 876
            DAMLE ++ E  VDVYG+V  +R QR  MVQ E QY  IH+AL+E    G TEV    L+
Sbjct: 1565 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1624

Query: 877  PYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRV 935
             Y+  + + +P    + +E EF+RL + ++  ++ I  N   NK KNR  N++PY+  RV
Sbjct: 1625 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1684

Query: 936  PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGD 995
             L+                        E S YINASFI  Y + +  IA QGPL ET  D
Sbjct: 1685 CLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1725

Query: 996  FWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF 1054
            FW+M+++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR F
Sbjct: 1726 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1785

Query: 1055 ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTP 1114
            ++  ++   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P
Sbjct: 1786 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------P 1837

Query: 1115 LLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
            + +HC  G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T ++YQF Y
Sbjct: 1838 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1895



 Score =  198 bits (503), Expect = 3e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 1662 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1721

Query: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 1722 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1779

Query: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 1780 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1838

Query: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E +Y   +QA 
Sbjct: 1839 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1898

Query: 860  VEY 862
            +EY
Sbjct: 1899 LEY 1901



 Score =  155 bits (392), Expect = 2e-37
 Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)

Query: 894  LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 953
            L  E++ +   + +  +H  N E NK KNR +NVI YD++RV L+               
Sbjct: 1355 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 1398

Query: 954  SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 1013
                  +    S YINA+++  Y      IA QGPL ET GDFW+M+++++   IVM+T 
Sbjct: 1399 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1454

Query: 1014 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 1072
            L+   +  C QYW   G +TYG I+V L DT + +T+ +R F L  +   + R V Q+Q+
Sbjct: 1455 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1514

Query: 1073 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1132
            T W    +P  P   ++ ++ VK   P            + P+++HC  G  +TG F  +
Sbjct: 1515 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1564

Query: 1133 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1186
              +LE  + E+ VD++  V  +R  R  MV T +QY F+++ +       N +V
Sbjct: 1565 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1618



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 33/133 (24%), Positives = 58/133 (43%), Gaps = 17/133 (12%)

Query: 335 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 392
           +KT  G PG+P  +   + +     ++W+PP Q S   + L + + +  ++         
Sbjct: 505 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 564

Query: 393 KYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-------SAPPSQVWNMTVSM 445
            Y +++LKP T+Y     A+ +A     G  A      +       SAPP  V  ++V  
Sbjct: 565 SYVVEDLKPNTEY-----AFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRS 619

Query: 446 TSDNSMHVKCRPP 458
           T   ++ V  RPP
Sbjct: 620 T---AILVSWRPP 629


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
            isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score =  397 bits (1019), Expect = e-110
 Identities = 235/598 (39%), Positives = 333/598 (55%), Gaps = 33/598 (5%)

Query: 577  LMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDI 636
            +++  PI    + E  +R  A++      E++SI     +F  + +    N+ KNRY ++
Sbjct: 920  MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANV 978

Query: 637  LPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKAT 696
            + YD++RV L  I G  GS+YINA+Y+DG++    YIA QGP  ET  DFWRM+WEQ++ 
Sbjct: 979  IAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSA 1038

Query: 697  VIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA 756
             IVM+TR EE +R KC +YWP+   GT  +G + V +        + ++  ++ +K   +
Sbjct: 1039 TIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNGSS 1095

Query: 757  TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGI 816
              REV   QFT+WPDHGVPE P   L   RRV   +   +GPIVVHCSAGVGRTG +I I
Sbjct: 1096 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1155

Query: 817  DAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELH 876
            DAMLE ++ E  VDVYG+V  +R QR  MVQ E QY  IH+AL+E    G TEV    L+
Sbjct: 1156 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1215

Query: 877  PYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRV 935
             Y+  + + +P    + +E EF+RL + ++  ++ I  N   NK KNR  N++PY+  RV
Sbjct: 1216 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1275

Query: 936  PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGD 995
             L+                        E S YINASFI  Y + +  IA QGPL ET  D
Sbjct: 1276 CLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1316

Query: 996  FWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF 1054
            FW+M+++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR F
Sbjct: 1317 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1376

Query: 1055 ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTP 1114
            ++  ++   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P
Sbjct: 1377 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------P 1428

Query: 1115 LLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
            + +HC  G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T ++YQF Y
Sbjct: 1429 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1486



 Score =  198 bits (503), Expect = 3e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312

Query: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 1313 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1370

Query: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 1371 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1429

Query: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E +Y   +QA 
Sbjct: 1430 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1489

Query: 860  VEY 862
            +EY
Sbjct: 1490 LEY 1492



 Score =  155 bits (392), Expect = 2e-37
 Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)

Query: 894  LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 953
            L  E++ +   + +  +H  N E NK KNR +NVI YD++RV L+               
Sbjct: 946  LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 989

Query: 954  SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 1013
                  +    S YINA+++  Y      IA QGPL ET GDFW+M+++++   IVM+T 
Sbjct: 990  ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1045

Query: 1014 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 1072
            L+   +  C QYW   G +TYG I+V L DT + +T+ +R F L  +   + R V Q+Q+
Sbjct: 1046 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1105

Query: 1073 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1132
            T W    +P  P   ++ ++ VK   P            + P+++HC  G  +TG F  +
Sbjct: 1106 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1155

Query: 1133 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1186
              +LE  + E+ VD++  V  +R  R  MV T +QY F+++ +       N +V
Sbjct: 1156 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1209



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 20/79 (25%), Positives = 38/79 (48%), Gaps = 2/79 (2%)

Query: 335 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 392
           +KT  G PG+P  +   + +     ++W+PP Q S   + L + + +  ++         
Sbjct: 505 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 564

Query: 393 KYDLQNLKPYTKYVLSLHA 411
            Y +++LKP T+Y   L A
Sbjct: 565 SYVVEDLKPNTEYAFRLAA 583


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
            precursor [Homo sapiens]
          Length = 1502

 Score =  396 bits (1018), Expect = e-110
 Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)

Query: 582  PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 641
            PI    L +  +R  A++   F  E++SI     +F  + +    N+ KNRY +++ YD+
Sbjct: 926  PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 984

Query: 642  NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 701
            +RV LS I G  GS+Y+NA+YIDG+++   YIA QG   ET  DFWRMIWEQ++  +VM+
Sbjct: 985  SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1044

Query: 702  TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 761
            T+ EE +R KC +YWPS   GT   G V V +        Y ++   +  K   +  REV
Sbjct: 1045 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1101

Query: 762  THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 821
               QFT+WPDHGVPE P   L   RRV   +   +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 1102 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1161

Query: 822  GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 881
             ++ E  VD+YG+V  +R QR  MVQ E QYI IH AL+E    G TEV    L+ Y+  
Sbjct: 1162 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1221

Query: 882  MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 940
            + + +     + +E EF+RL S ++  ++ I  N   NK KNR  N++PY+  RV L+  
Sbjct: 1222 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1279

Query: 941  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1000
                                  E S YINASFI  Y + +  IA QGPL ET  DFW+M+
Sbjct: 1280 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1322

Query: 1001 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1059
            ++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR F++  +
Sbjct: 1323 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1382

Query: 1060 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1119
            +   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ +HC
Sbjct: 1383 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1434

Query: 1120 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
              G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T +QYQF Y
Sbjct: 1435 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1487



 Score =  197 bits (501), Expect = 5e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 1254 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1313

Query: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 1314 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1371

Query: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 1372 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1430

Query: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY   ++A 
Sbjct: 1431 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1490

Query: 860  VEY 862
            +EY
Sbjct: 1491 LEY 1493



 Score =  156 bits (395), Expect = 1e-37
 Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)

Query: 870  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 929
            + + EL  ++  +K  D          E++ +   + +  +H  N E NK KNR +NVI 
Sbjct: 927  IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 981

Query: 930  YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 989
            YD++RV L         S  +    SD          Y+NA++I  Y K    IA QG L
Sbjct: 982  YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1022

Query: 990  KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 1048
             ET GDFW+MI++++   +VM+T+L+   +  C QYW   G +T+G ++V L DT + +T
Sbjct: 1023 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1082

Query: 1049 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 1108
            Y +R F L  +   + R V Q+Q+T W    +P  P   ++ ++ VK   P         
Sbjct: 1083 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1135

Query: 1109 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1168
               + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V  +R  R  MV T +QY
Sbjct: 1136 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1192

Query: 1169 QFLYDVIASTYPAQNGQVKKNN 1190
             F++D +       N +V   N
Sbjct: 1193 IFIHDALLEAVTCGNTEVPARN 1214



 Score = 34.3 bits (77), Expect = 0.77
 Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 19/161 (11%)

Query: 267 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 314
           + TTI ++WK  E            +T D TQ++    +  + + D++   + NL P+  
Sbjct: 427 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 484

Query: 315 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 372
           Y        +      +S I + T  G PG+P       E+    +++W PP+  +  N+
Sbjct: 485 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 544

Query: 373 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHA 411
            L Y   +  E+  + ++     Y LQ LKP + Y   L A
Sbjct: 545 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAA 584


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score =  396 bits (1018), Expect = e-110
 Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)

Query: 582  PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 641
            PI    L +  +R  A++   F  E++SI     +F  + +    N+ KNRY +++ YD+
Sbjct: 1336 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 1394

Query: 642  NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 701
            +RV LS I G  GS+Y+NA+YIDG+++   YIA QG   ET  DFWRMIWEQ++  +VM+
Sbjct: 1395 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1454

Query: 702  TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 761
            T+ EE +R KC +YWPS   GT   G V V +        Y ++   +  K   +  REV
Sbjct: 1455 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1511

Query: 762  THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 821
               QFT+WPDHGVPE P   L   RRV   +   +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 1512 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1571

Query: 822  GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 881
             ++ E  VD+YG+V  +R QR  MVQ E QYI IH AL+E    G TEV    L+ Y+  
Sbjct: 1572 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1631

Query: 882  MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 940
            + + +     + +E EF+RL S ++  ++ I  N   NK KNR  N++PY+  RV L+  
Sbjct: 1632 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1689

Query: 941  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1000
                                  E S YINASFI  Y + +  IA QGPL ET  DFW+M+
Sbjct: 1690 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1732

Query: 1001 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1059
            ++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR F++  +
Sbjct: 1733 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1792

Query: 1060 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1119
            +   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ +HC
Sbjct: 1793 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1844

Query: 1120 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
              G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T +QYQF Y
Sbjct: 1845 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1897



 Score =  197 bits (501), Expect = 5e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 1664 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1723

Query: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 1724 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1781

Query: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 1782 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1840

Query: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY   ++A 
Sbjct: 1841 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1900

Query: 860  VEY 862
            +EY
Sbjct: 1901 LEY 1903



 Score =  156 bits (395), Expect = 1e-37
 Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)

Query: 870  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 929
            + + EL  ++  +K  D          E++ +   + +  +H  N E NK KNR +NVI 
Sbjct: 1337 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 1391

Query: 930  YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 989
            YD++RV L         S  +    SD          Y+NA++I  Y K    IA QG L
Sbjct: 1392 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1432

Query: 990  KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 1048
             ET GDFW+MI++++   +VM+T+L+   +  C QYW   G +T+G ++V L DT + +T
Sbjct: 1433 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1492

Query: 1049 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 1108
            Y +R F L  +   + R V Q+Q+T W    +P  P   ++ ++ VK   P         
Sbjct: 1493 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1545

Query: 1109 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1168
               + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V  +R  R  MV T +QY
Sbjct: 1546 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1602

Query: 1169 QFLYDVIASTYPAQNGQVKKNN 1190
             F++D +       N +V   N
Sbjct: 1603 IFIHDALLEAVTCGNTEVPARN 1624



 Score = 39.3 bits (90), Expect = 0.024
 Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 22/226 (9%)

Query: 267 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 314
           + TTI ++WK  E            +T D TQ++    +  + + D++   + NL P+  
Sbjct: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 487

Query: 315 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 372
           Y        +      +S I + T  G PG+P       E+    +++W PP+  +  N+
Sbjct: 488 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 547

Query: 373 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT 430
            L Y   +  E+  + ++     Y LQ LKP + Y   L A     +  + +A +   T 
Sbjct: 548 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEISARTM 605

Query: 431 KSAPPSQVWNMTVSMTSDNSMHVKCRPP--RDRNGPHERYHLEVEA 474
           +S P +   +++ +  S  S+ V  +PP    +NG    Y ++  A
Sbjct: 606 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 651



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 29/124 (23%), Positives = 50/124 (40%), Gaps = 11/124 (8%)

Query: 345 PQIIFCRSEAAHQGVITWNPPQRSFHN--FTLCYIKETEKD--------CLNLDKNLIKY 394
           PQ I C S ++   +++W PP     N   T   IK T  D         L +  +  KY
Sbjct: 613 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 672

Query: 395 DLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVK 454
            L+ L+ +T+Y +++ A+          + +   T +  P      + V   +  S+ V 
Sbjct: 673 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR-TNEDVPSGPPRKVEVEAVNSTSVKVS 731

Query: 455 CRPP 458
            R P
Sbjct: 732 WRSP 735



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 10/127 (7%)

Query: 396 LQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKC 455
           +  L+P T Y L++ AY   K     S      TT + P      + ++ T  N+  ++ 
Sbjct: 787 ISGLQPETSYSLTVTAYT-TKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQW 843

Query: 456 RPPRDRNGPHERYHL-----EVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGD 510
            PP D  GP + Y L     ++E   TL    S K   F   D+     Y F+    N  
Sbjct: 844 HPPVDTFGPLQGYRLKFGRKDMEPLTTL--EFSEKEDHFTATDIHKGASYVFRLSARNKV 901

Query: 511 YPGEPFI 517
             GE  +
Sbjct: 902 GFGEEMV 908


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score =  396 bits (1018), Expect = e-110
 Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)

Query: 582  PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 641
            PI    L +  +R  A++   F  E++SI     +F  + +    N+ KNRY +++ YD+
Sbjct: 1323 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 1381

Query: 642  NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 701
            +RV LS I G  GS+Y+NA+YIDG+++   YIA QG   ET  DFWRMIWEQ++  +VM+
Sbjct: 1382 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1441

Query: 702  TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 761
            T+ EE +R KC +YWPS   GT   G V V +        Y ++   +  K   +  REV
Sbjct: 1442 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1498

Query: 762  THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 821
               QFT+WPDHGVPE P   L   RRV   +   +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 1499 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1558

Query: 822  GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 881
             ++ E  VD+YG+V  +R QR  MVQ E QYI IH AL+E    G TEV    L+ Y+  
Sbjct: 1559 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1618

Query: 882  MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 940
            + + +     + +E EF+RL S ++  ++ I  N   NK KNR  N++PY+  RV L+  
Sbjct: 1619 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1676

Query: 941  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1000
                                  E S YINASFI  Y + +  IA QGPL ET  DFW+M+
Sbjct: 1677 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1719

Query: 1001 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1059
            ++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR F++  +
Sbjct: 1720 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1779

Query: 1060 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1119
            +   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ +HC
Sbjct: 1780 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1831

Query: 1120 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
              G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T +QYQF Y
Sbjct: 1832 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1884



 Score =  197 bits (501), Expect = 5e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 1651 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1710

Query: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 1711 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1768

Query: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 1769 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1827

Query: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY   ++A 
Sbjct: 1828 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1887

Query: 860  VEY 862
            +EY
Sbjct: 1888 LEY 1890



 Score =  156 bits (395), Expect = 1e-37
 Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)

Query: 870  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 929
            + + EL  ++  +K  D          E++ +   + +  +H  N E NK KNR +NVI 
Sbjct: 1324 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 1378

Query: 930  YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 989
            YD++RV L         S  +    SD          Y+NA++I  Y K    IA QG L
Sbjct: 1379 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1419

Query: 990  KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 1048
             ET GDFW+MI++++   +VM+T+L+   +  C QYW   G +T+G ++V L DT + +T
Sbjct: 1420 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1479

Query: 1049 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 1108
            Y +R F L  +   + R V Q+Q+T W    +P  P   ++ ++ VK   P         
Sbjct: 1480 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1532

Query: 1109 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1168
               + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V  +R  R  MV T +QY
Sbjct: 1533 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1589

Query: 1169 QFLYDVIASTYPAQNGQVKKNN 1190
             F++D +       N +V   N
Sbjct: 1590 IFIHDALLEAVTCGNTEVPARN 1611



 Score = 39.3 bits (90), Expect = 0.024
 Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 22/226 (9%)

Query: 267 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 314
           + TTI ++WK  E            +T D TQ++    +  + + D++   + NL P+  
Sbjct: 417 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 474

Query: 315 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 372
           Y        +      +S I + T  G PG+P       E+    +++W PP+  +  N+
Sbjct: 475 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 534

Query: 373 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT 430
            L Y   +  E+  + ++     Y LQ LKP + Y   L A     +  + +A +   T 
Sbjct: 535 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEISARTM 592

Query: 431 KSAPPSQVWNMTVSMTSDNSMHVKCRPP--RDRNGPHERYHLEVEA 474
           +S P +   +++ +  S  S+ V  +PP    +NG    Y ++  A
Sbjct: 593 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 638



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 29/124 (23%), Positives = 50/124 (40%), Gaps = 11/124 (8%)

Query: 345 PQIIFCRSEAAHQGVITWNPPQRSFHN--FTLCYIKETEKD--------CLNLDKNLIKY 394
           PQ I C S ++   +++W PP     N   T   IK T  D         L +  +  KY
Sbjct: 600 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 659

Query: 395 DLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVK 454
            L+ L+ +T+Y +++ A+          + +   T +  P      + V   +  S+ V 
Sbjct: 660 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR-TNEDVPSGPPRKVEVEAVNSTSVKVS 718

Query: 455 CRPP 458
            R P
Sbjct: 719 WRSP 722



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 10/127 (7%)

Query: 396 LQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKC 455
           +  L+P T Y L++ AY   K     S      TT + P      + ++ T  N+  ++ 
Sbjct: 774 ISGLQPETSYSLTVTAYT-TKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQW 830

Query: 456 RPPRDRNGPHERYHL-----EVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGD 510
            PP D  GP + Y L     ++E   TL    S K   F   D+     Y F+    N  
Sbjct: 831 HPPVDTFGPLQGYRLKFGRKDMEPLTTL--EFSEKEDHFTATDIHKGASYVFRLSARNKV 888

Query: 511 YPGEPFI 517
             GE  +
Sbjct: 889 GFGEEMV 895


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score =  396 bits (1018), Expect = e-110
 Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)

Query: 582  PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 641
            PI    L +  +R  A++   F  E++SI     +F  + +    N+ KNRY +++ YD+
Sbjct: 1327 PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 1385

Query: 642  NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 701
            +RV LS I G  GS+Y+NA+YIDG+++   YIA QG   ET  DFWRMIWEQ++  +VM+
Sbjct: 1386 SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1445

Query: 702  TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 761
            T+ EE +R KC +YWPS   GT   G V V +        Y ++   +  K   +  REV
Sbjct: 1446 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1502

Query: 762  THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 821
               QFT+WPDHGVPE P   L   RRV   +   +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 1503 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1562

Query: 822  GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 881
             ++ E  VD+YG+V  +R QR  MVQ E QYI IH AL+E    G TEV    L+ Y+  
Sbjct: 1563 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1622

Query: 882  MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 940
            + + +     + +E EF+RL S ++  ++ I  N   NK KNR  N++PY+  RV L+  
Sbjct: 1623 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1680

Query: 941  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1000
                                  E S YINASFI  Y + +  IA QGPL ET  DFW+M+
Sbjct: 1681 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1723

Query: 1001 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1059
            ++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR F++  +
Sbjct: 1724 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1783

Query: 1060 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1119
            +   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ +HC
Sbjct: 1784 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1835

Query: 1120 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
              G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T +QYQF Y
Sbjct: 1836 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1888



 Score =  197 bits (501), Expect = 5e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 1655 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1714

Query: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 1715 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1772

Query: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 1773 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1831

Query: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY   ++A 
Sbjct: 1832 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1891

Query: 860  VEY 862
            +EY
Sbjct: 1892 LEY 1894



 Score =  156 bits (395), Expect = 1e-37
 Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)

Query: 870  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 929
            + + EL  ++  +K  D          E++ +   + +  +H  N E NK KNR +NVI 
Sbjct: 1328 IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 1382

Query: 930  YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 989
            YD++RV L         S  +    SD          Y+NA++I  Y K    IA QG L
Sbjct: 1383 YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1423

Query: 990  KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 1048
             ET GDFW+MI++++   +VM+T+L+   +  C QYW   G +T+G ++V L DT + +T
Sbjct: 1424 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1483

Query: 1049 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 1108
            Y +R F L  +   + R V Q+Q+T W    +P  P   ++ ++ VK   P         
Sbjct: 1484 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1536

Query: 1109 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1168
               + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V  +R  R  MV T +QY
Sbjct: 1537 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1593

Query: 1169 QFLYDVIASTYPAQNGQVKKNN 1190
             F++D +       N +V   N
Sbjct: 1594 IFIHDALLEAVTCGNTEVPARN 1615



 Score = 39.3 bits (90), Expect = 0.024
 Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 22/226 (9%)

Query: 267 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 314
           + TTI ++WK  E            +T D TQ++    +  + + D++   + NL P+  
Sbjct: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 487

Query: 315 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 372
           Y        +      +S I + T  G PG+P       E+    +++W PP+  +  N+
Sbjct: 488 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 547

Query: 373 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT 430
            L Y   +  E+  + ++     Y LQ LKP + Y   L A     +  + +A +   T 
Sbjct: 548 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEISARTM 605

Query: 431 KSAPPSQVWNMTVSMTSDNSMHVKCRPP--RDRNGPHERYHLEVEA 474
           +S P +   +++ +  S  S+ V  +PP    +NG    Y ++  A
Sbjct: 606 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 651



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 47/218 (21%), Positives = 82/218 (37%), Gaps = 37/218 (16%)

Query: 345 PQIIFCRSEAAHQGVITWNPPQRSFHN--FTLCYIKETEKD--------CLNLDKNLIKY 394
           PQ I C S ++   +++W PP     N   T   IK T  D         L +  +  KY
Sbjct: 613 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKY 672

Query: 395 DLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVK 454
            L+ L+ +T+Y +++ A+          + +   T +  P      + V   +  S+ V 
Sbjct: 673 LLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR-TNEDVPSGPPRKVEVEAVNSTSVKVS 731

Query: 455 CRP--PRDRNGPHERYHLEV-------EAGNTLVRNESHKNC-DFRVKDLQYSTDY--TF 502
            R   P  ++G    Y +           G  ++++    +  D  +  LQ  T Y  T 
Sbjct: 732 WRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTV 791

Query: 503 KAYFHNGD--------------YPGEPFILHHSTSYNS 526
            AY   GD               PG+P ++ + T  N+
Sbjct: 792 TAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNT 829



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 10/127 (7%)

Query: 396 LQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKC 455
           +  L+P T Y L++ AY   K     S      TT + P      + ++ T  N+  ++ 
Sbjct: 778 ISGLQPETSYSLTVTAYT-TKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQW 834

Query: 456 RPPRDRNGPHERYHL-----EVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGD 510
            PP D  GP + Y L     ++E   TL    S K   F   D+     Y F+    N  
Sbjct: 835 HPPVDTFGPLQGYRLKFGRKDMEPLTTL--EFSEKEDHFTATDIHKGASYVFRLSARNKV 892

Query: 511 YPGEPFI 517
             GE  +
Sbjct: 893 GFGEEMV 899


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
            precursor [Homo sapiens]
          Length = 1501

 Score =  396 bits (1018), Expect = e-110
 Identities = 238/593 (40%), Positives = 328/593 (55%), Gaps = 33/593 (5%)

Query: 582  PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 641
            PI    L +  +R  A++   F  E++SI     +F  + +    N+ KNRY +++ YD+
Sbjct: 925  PIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 983

Query: 642  NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 701
            +RV LS I G  GS+Y+NA+YIDG+++   YIA QG   ET  DFWRMIWEQ++  +VM+
Sbjct: 984  SRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMM 1043

Query: 702  TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREV 761
            T+ EE +R KC +YWPS   GT   G V V +        Y ++   +  K   +  REV
Sbjct: 1044 TKLEERSRVKCDQYWPS--RGTETHGLVQVTLLDTVELATYCVRTFALY-KNGSSEKREV 1100

Query: 762  THIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLE 821
               QFT+WPDHGVPE P   L   RRV   +   +GP+VVHCSAGVGRTG +I IDAMLE
Sbjct: 1101 RQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLE 1160

Query: 822  GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHN 881
             ++ E  VD+YG+V  +R QR  MVQ E QYI IH AL+E    G TEV    L+ Y+  
Sbjct: 1161 RIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQK 1220

Query: 882  MKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRVPLKHE 940
            + + +     + +E EF+RL S ++  ++ I  N   NK KNR  N++PY+  RV L+  
Sbjct: 1221 LTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQ-- 1278

Query: 941  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1000
                                  E S YINASFI  Y + +  IA QGPL ET  DFW+M+
Sbjct: 1279 -----------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRML 1321

Query: 1001 FQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1059
            ++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR F++  +
Sbjct: 1322 WEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDA 1381

Query: 1060 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1119
            +   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P+ +HC
Sbjct: 1382 RDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------PISVHC 1433

Query: 1120 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
              G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T +QYQF Y
Sbjct: 1434 SAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY 1486



 Score =  197 bits (501), Expect = 5e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312

Query: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 1313 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1370

Query: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 1371 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1429

Query: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E QY   ++A 
Sbjct: 1430 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1489

Query: 860  VEY 862
            +EY
Sbjct: 1490 LEY 1492



 Score =  156 bits (395), Expect = 1e-37
 Identities = 100/322 (31%), Positives = 160/322 (49%), Gaps = 35/322 (10%)

Query: 870  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 929
            + + EL  ++  +K  D          E++ +   + +  +H  N E NK KNR +NVI 
Sbjct: 926  IPILELADHIERLKANDNLK----FSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIA 980

Query: 930  YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 989
            YD++RV L         S  +    SD          Y+NA++I  Y K    IA QG L
Sbjct: 981  YDHSRVLL---------SAIEGIPGSD----------YVNANYIDGYRKQNAYIATQGSL 1021

Query: 990  KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSST 1048
             ET GDFW+MI++++   +VM+T+L+   +  C QYW   G +T+G ++V L DT + +T
Sbjct: 1022 PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELAT 1081

Query: 1049 YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNK 1108
            Y +R F L  +   + R V Q+Q+T W    +P  P   ++ ++ VK   P         
Sbjct: 1082 YCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPD------- 1134

Query: 1109 HHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQY 1168
               + P+++HC  G  +TG F  +  +LE  + E+ VDI+  V  +R  R  MV T +QY
Sbjct: 1135 ---AGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1191

Query: 1169 QFLYDVIASTYPAQNGQVKKNN 1190
             F++D +       N +V   N
Sbjct: 1192 IFIHDALLEAVTCGNTEVPARN 1213



 Score = 34.3 bits (77), Expect = 0.77
 Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 19/161 (11%)

Query: 267 ADTTICLKWKNIET-----------FTCD-TQNITYRFQCGNMIFDNKEIKLENLEPEHE 314
           + TTI ++WK  E            +T D TQ++    +  + + D++   + NL P+  
Sbjct: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK--HNVADSQITTIGNLVPQKT 487

Query: 315 YKCDSEILYNNHKFTNASKI-IKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQR-SFHNF 372
           Y        +      +S I + T  G PG+P       E+    +++W PP+  +  N+
Sbjct: 488 YSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANY 547

Query: 373 TLCYI--KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHA 411
            L Y   +  E+  + ++     Y LQ LKP + Y   L A
Sbjct: 548 ELVYKDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAA 587


>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
            precursor [Homo sapiens]
          Length = 1441

 Score =  356 bits (913), Expect = 9e-98
 Identities = 219/628 (34%), Positives = 328/628 (52%), Gaps = 50/628 (7%)

Query: 555  HKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVF 614
            H  R+C  D  +    RD  +  + V    AD+L    + K   +G  F  E++++P   
Sbjct: 848  HPYRTC--DPVEMSYPRDQFQPAIRV----ADLLQHITQMK-RGQGYGFKEEYEALPEGQ 900

Query: 615  SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA 674
            +      A++  N+NKNRY +I+ YD++RV L  ++GD  S+YINA+YIDG+  PR YIA
Sbjct: 901  TA-SWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIA 959

Query: 675  AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKIN 734
             QGP  ETV DFWRMIW++ +  IVMVT   E  R KC  YWP   + T  +GD+ V + 
Sbjct: 960  TQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP---DDTEVYGDIKVTLI 1016

Query: 735  QHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF 794
            + +   +Y+I+    V KK     RE+    FTSWPDHGVP     LL   R+V   +  
Sbjct: 1017 ETEPLAEYVIRTFT-VQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPP 1075

Query: 795  FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYIL 854
             +GPIVVHCSAG GRTG +I ID ML+  E E  VD++  V +LR QR  +VQ E QY+ 
Sbjct: 1076 EAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVF 1135

Query: 855  IHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRL----PSYRSWRTQ 910
            +H A++E    G T + + E     +N+ + DP +  S ++ EFQ L    P  R     
Sbjct: 1136 VHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRP-EDC 1194

Query: 911  HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINA 970
             IG    N  KNR+ +V+P D   +P    ++                    E S YINA
Sbjct: 1195 SIGLLPRNHDKNRSMDVLPLD-RCLPFLISVD-------------------GESSNYINA 1234

Query: 971  SFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK 1030
            + + S+ +P   +  Q PL  T+ DFW+++F      +VML E+     + C QYW E  
Sbjct: 1235 ALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKT 1292

Query: 1031 Q-TYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKE 1086
               YG I+V+    D       R+F + +  R     R V   QY  W +    P   + 
Sbjct: 1293 SGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRS 1352

Query: 1087 LISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVD 1146
            L+ +++ +++   Q +  EG         ++HC +G  ++G FCA+ ++ E  + + ++D
Sbjct: 1353 LLKVVRRLEKWQEQYDGREGR-------TVVHCLNGGGRSGTFCAICSVCEMIQQQNIID 1405

Query: 1147 IFQVVKALRKARPGMVSTFEQYQFLYDV 1174
            +F +VK LR  +  MV T EQY+F+Y+V
Sbjct: 1406 VFHIVKTLRNNKSNMVETLEQYKFVYEV 1433



 Score =  165 bits (417), Expect = 3e-40
 Identities = 100/308 (32%), Positives = 162/308 (52%), Gaps = 38/308 (12%)

Query: 870  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYR--SWRTQHIGNQEENKSKNRNSNV 927
            + +++L  ++  MK+     +    + E++ LP  +  SW T     ++EN++KNR  N+
Sbjct: 869  IRVADLLQHITQMKR----GQGYGFKEEYEALPEGQTASWDT---AKEDENRNKNRYGNI 921

Query: 928  IPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQG 987
            I YD++RV L            D D  SD          YINA++I  Y +P   IA QG
Sbjct: 922  ISYDHSRVRLL---------VLDGDPHSD----------YINANYIDGYHRPRHYIATQG 962

Query: 988  PLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSS 1047
            P++ET+ DFW+MI+Q     IVM+T L    +  C +YW +  + YGDI+V L +T+  +
Sbjct: 963  PMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLA 1022

Query: 1048 TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 1107
             Y +R F ++     + R +  + +T+W    +P     L+  ++ VK   P +      
Sbjct: 1023 EYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPE------ 1076

Query: 1108 KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1167
                + P+++HC  G+ +TG F A+  +L+ AE E VVDIF  V+ LR  R  +V T EQ
Sbjct: 1077 ----AGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQ 1132

Query: 1168 YQFLYDVI 1175
            Y F++D I
Sbjct: 1133 YVFVHDAI 1140



 Score =  131 bits (330), Expect = 4e-30
 Identities = 79/243 (32%), Positives = 125/243 (51%), Gaps = 10/243 (4%)

Query: 625  PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 684
            P N +KNR +D+LP D     L  ++G++ SNYINA+ +D  K+P  ++  Q P   TV 
Sbjct: 1200 PRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVVTQHPLPNTVA 1258

Query: 685  DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 744
            DFWR++++   + +VM+   E      C +YWP    G   +G + V+        D I 
Sbjct: 1259 DFWRLVFDYNCSSVVMLN--EMDTAQFCMQYWPEKTSG--CYGPIQVEFVSADIDEDIIH 1314

Query: 745  QKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAFSNFFSGP---I 799
            +   I N      G R V H+Q+  WP +   P     LLK+ RR+  +   + G     
Sbjct: 1315 RIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRT 1374

Query: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
            VVHC  G GR+GT+  I ++ E ++ +N +DV+  V  LR  +  MV+   QY  +++  
Sbjct: 1375 VVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVA 1434

Query: 860  VEY 862
            +EY
Sbjct: 1435 LEY 1437


>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
            precursor [Homo sapiens]
          Length = 1460

 Score =  356 bits (913), Expect = 9e-98
 Identities = 219/628 (34%), Positives = 328/628 (52%), Gaps = 50/628 (7%)

Query: 555  HKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVF 614
            H  R+C  D  +    RD  +  + V    AD+L    + K   +G  F  E++++P   
Sbjct: 867  HPYRTC--DPVEMSYPRDQFQPAIRV----ADLLQHITQMK-RGQGYGFKEEYEALPEGQ 919

Query: 615  SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA 674
            +      A++  N+NKNRY +I+ YD++RV L  ++GD  S+YINA+YIDG+  PR YIA
Sbjct: 920  TA-SWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIA 978

Query: 675  AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKIN 734
             QGP  ETV DFWRMIW++ +  IVMVT   E  R KC  YWP   + T  +GD+ V + 
Sbjct: 979  TQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP---DDTEVYGDIKVTLI 1035

Query: 735  QHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF 794
            + +   +Y+I+    V KK     RE+    FTSWPDHGVP     LL   R+V   +  
Sbjct: 1036 ETEPLAEYVIRTFT-VQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPP 1094

Query: 795  FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYIL 854
             +GPIVVHCSAG GRTG +I ID ML+  E E  VD++  V +LR QR  +VQ E QY+ 
Sbjct: 1095 EAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVF 1154

Query: 855  IHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRL----PSYRSWRTQ 910
            +H A++E    G T + + E     +N+ + DP +  S ++ EFQ L    P  R     
Sbjct: 1155 VHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRP-EDC 1213

Query: 911  HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINA 970
             IG    N  KNR+ +V+P D   +P    ++                    E S YINA
Sbjct: 1214 SIGLLPRNHDKNRSMDVLPLD-RCLPFLISVD-------------------GESSNYINA 1253

Query: 971  SFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK 1030
            + + S+ +P   +  Q PL  T+ DFW+++F      +VML E+     + C QYW E  
Sbjct: 1254 ALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKT 1311

Query: 1031 Q-TYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKE 1086
               YG I+V+    D       R+F + +  R     R V   QY  W +    P   + 
Sbjct: 1312 SGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRS 1371

Query: 1087 LISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVD 1146
            L+ +++ +++   Q +  EG         ++HC +G  ++G FCA+ ++ E  + + ++D
Sbjct: 1372 LLKVVRRLEKWQEQYDGREGR-------TVVHCLNGGGRSGTFCAICSVCEMIQQQNIID 1424

Query: 1147 IFQVVKALRKARPGMVSTFEQYQFLYDV 1174
            +F +VK LR  +  MV T EQY+F+Y+V
Sbjct: 1425 VFHIVKTLRNNKSNMVETLEQYKFVYEV 1452



 Score =  165 bits (417), Expect = 3e-40
 Identities = 100/308 (32%), Positives = 162/308 (52%), Gaps = 38/308 (12%)

Query: 870  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYR--SWRTQHIGNQEENKSKNRNSNV 927
            + +++L  ++  MK+     +    + E++ LP  +  SW T     ++EN++KNR  N+
Sbjct: 888  IRVADLLQHITQMKR----GQGYGFKEEYEALPEGQTASWDT---AKEDENRNKNRYGNI 940

Query: 928  IPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQG 987
            I YD++RV L            D D  SD          YINA++I  Y +P   IA QG
Sbjct: 941  ISYDHSRVRLL---------VLDGDPHSD----------YINANYIDGYHRPRHYIATQG 981

Query: 988  PLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSS 1047
            P++ET+ DFW+MI+Q     IVM+T L    +  C +YW +  + YGDI+V L +T+  +
Sbjct: 982  PMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLA 1041

Query: 1048 TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 1107
             Y +R F ++     + R +  + +T+W    +P     L+  ++ VK   P +      
Sbjct: 1042 EYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPE------ 1095

Query: 1108 KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1167
                + P+++HC  G+ +TG F A+  +L+ AE E VVDIF  V+ LR  R  +V T EQ
Sbjct: 1096 ----AGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQ 1151

Query: 1168 YQFLYDVI 1175
            Y F++D I
Sbjct: 1152 YVFVHDAI 1159



 Score =  131 bits (330), Expect = 4e-30
 Identities = 79/243 (32%), Positives = 125/243 (51%), Gaps = 10/243 (4%)

Query: 625  PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 684
            P N +KNR +D+LP D     L  ++G++ SNYINA+ +D  K+P  ++  Q P   TV 
Sbjct: 1219 PRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVVTQHPLPNTVA 1277

Query: 685  DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 744
            DFWR++++   + +VM+   E      C +YWP    G   +G + V+        D I 
Sbjct: 1278 DFWRLVFDYNCSSVVMLN--EMDTAQFCMQYWPEKTSG--CYGPIQVEFVSADIDEDIIH 1333

Query: 745  QKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAFSNFFSGP---I 799
            +   I N      G R V H+Q+  WP +   P     LLK+ RR+  +   + G     
Sbjct: 1334 RIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRT 1393

Query: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
            VVHC  G GR+GT+  I ++ E ++ +N +DV+  V  LR  +  MV+   QY  +++  
Sbjct: 1394 VVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVA 1453

Query: 860  VEY 862
            +EY
Sbjct: 1454 LEY 1456


>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
            precursor [Homo sapiens]
          Length = 1452

 Score =  347 bits (889), Expect = 5e-95
 Identities = 211/598 (35%), Positives = 309/598 (51%), Gaps = 44/598 (7%)

Query: 585  ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRV 644
            AD+L    + K A EG  F  E++S     S  P   A+K  N+ KNRY +I+ YD++RV
Sbjct: 883  ADLLQHITQMKCA-EGYGFKEEYESFFEGQSA-PWDSAKKDENRMKNRYGNIIAYDHSRV 940

Query: 645  ELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRC 704
             L  I GD  S+YIN +YIDG+  P  YIA QGP  ET+ DFWRM+W +    I+MVT  
Sbjct: 941  RLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNL 1000

Query: 705  EEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHI 764
             E  R KC +YWP   + T  + D+ V + + +   +Y+I+    V K+     RE+   
Sbjct: 1001 VEVGRVKCCKYWP---DDTEIYKDIKVTLIETELLAEYVIRTF-AVEKRGVHEIREIRQF 1056

Query: 765  QFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLE 824
             FT WPDHGVP     LL   R+V + S   +GP+VVHCSAG GRTG +I ID ML+  E
Sbjct: 1057 HFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAE 1116

Query: 825  AENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKK 884
             E  VD+Y  V +LR +R  MVQ E QY+ IH A++E    G+T V  S++    ++M K
Sbjct: 1117 REGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNK 1176

Query: 885  RDPPSEPSPLEAEFQRL----PSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHE 940
             DP +  S ++ EF+ L    P+ R      I     N  KNR  +++P D   +P    
Sbjct: 1177 LDPQTNSSQIKEEFRTLNMVTPTLRV-EDCSIALLPRNHEKNRCMDILPPD-RCLPFLIT 1234

Query: 941  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1000
            ++                    E S YINA+ + SY +P   I  Q PL  T+ DFW+++
Sbjct: 1235 ID-------------------GESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLV 1275

Query: 1001 FQRKVKVIVMLTELKHGDQEICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1059
                   +VML ++     ++C QYW E G   +G I+V+    D       R+F + ++
Sbjct: 1276 LDYHCTSVVMLNDV--DPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNA 1333

Query: 1060 KRKDS--RTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1116
             R     R V Q+Q+  W +    P   +  + +I+ V +   + N  EG         +
Sbjct: 1334 ARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGR-------TV 1386

Query: 1117 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV 1174
            +HC +G  ++G FCA+  + E    +  VD+F  VK LR  +P MV   +QY+F Y+V
Sbjct: 1387 VHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEV 1444



 Score =  160 bits (405), Expect = 7e-39
 Identities = 94/306 (30%), Positives = 158/306 (51%), Gaps = 38/306 (12%)

Query: 915  QEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM 974
            ++EN+ KNR  N+I YD++RV L               ++ + D++S+    YIN ++I 
Sbjct: 920  KDENRMKNRYGNIIAYDHSRVRL---------------QTIEGDTNSD----YINGNYID 960

Query: 975  SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG 1034
             Y +P   IA QGP++ETI DFW+M++      I+M+T L    +  C +YW +  + Y 
Sbjct: 961  GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK 1020

Query: 1035 DIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVV 1094
            DI+V L +T+  + Y +R F +      + R + Q+ +T W    +P     L+  ++ V
Sbjct: 1021 DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1080

Query: 1095 KQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKAL 1154
            K K P            + PL++HC  G+ +TG F  +  +L+ AE E VVDI+  V+ L
Sbjct: 1081 KSKSPPS----------AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVREL 1130

Query: 1155 RKARPGMVSTFEQYQFLYDVIA-------STYPAQNGQVKKNNHQEDKIEFDNEVDKVKQ 1207
            R  R  MV T EQY F++D I        ++ PA   QV+   +  +K++      ++K+
Sbjct: 1131 RSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPA--SQVRSLYYDMNKLDPQTNSSQIKE 1188

Query: 1208 DANCVN 1213
            +   +N
Sbjct: 1189 EFRTLN 1194



 Score =  127 bits (318), Expect = 9e-29
 Identities = 89/269 (33%), Positives = 130/269 (48%), Gaps = 13/269 (4%)

Query: 606  EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 662
            EF+++  V     +++   A  P N  KNR +DILP D     L  I+G++ SNYINA+ 
Sbjct: 1189 EFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAAL 1247

Query: 663  IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 722
            +D +K+P  +I  Q P   TV DFWR++ +   T +VM+   +      C +YWP  E G
Sbjct: 1248 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWP--ENG 1303

Query: 723  TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHL 780
                G + V+        D I +   I N      G R V   QF  WP +   P     
Sbjct: 1304 VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRS 1363

Query: 781  LLKLRRRVNAFSNFFSGP---IVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 837
             LKL R+V+ +   ++G     VVHC  G GR+GT+  I  + E L  +  VDV+  V  
Sbjct: 1364 FLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKT 1423

Query: 838  LRRQRCLMVQVEAQYILIHQALVEYNQFG 866
            LR  +  MV +  QY   ++  +EY   G
Sbjct: 1424 LRNNKPNMVDLLDQYKFCYEVALEYLNSG 1452


>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
            precursor [Homo sapiens]
          Length = 1465

 Score =  347 bits (889), Expect = 5e-95
 Identities = 211/598 (35%), Positives = 309/598 (51%), Gaps = 44/598 (7%)

Query: 585  ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRV 644
            AD+L    + K A EG  F  E++S     S  P   A+K  N+ KNRY +I+ YD++RV
Sbjct: 896  ADLLQHITQMKCA-EGYGFKEEYESFFEGQSA-PWDSAKKDENRMKNRYGNIIAYDHSRV 953

Query: 645  ELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRC 704
             L  I GD  S+YIN +YIDG+  P  YIA QGP  ET+ DFWRM+W +    I+MVT  
Sbjct: 954  RLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNL 1013

Query: 705  EEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHI 764
             E  R KC +YWP   + T  + D+ V + + +   +Y+I+    V K+     RE+   
Sbjct: 1014 VEVGRVKCCKYWP---DDTEIYKDIKVTLIETELLAEYVIRTF-AVEKRGVHEIREIRQF 1069

Query: 765  QFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLE 824
             FT WPDHGVP     LL   R+V + S   +GP+VVHCSAG GRTG +I ID ML+  E
Sbjct: 1070 HFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAE 1129

Query: 825  AENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKK 884
             E  VD+Y  V +LR +R  MVQ E QY+ IH A++E    G+T V  S++    ++M K
Sbjct: 1130 REGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNK 1189

Query: 885  RDPPSEPSPLEAEFQRL----PSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHE 940
             DP +  S ++ EF+ L    P+ R      I     N  KNR  +++P D   +P    
Sbjct: 1190 LDPQTNSSQIKEEFRTLNMVTPTLRV-EDCSIALLPRNHEKNRCMDILPPD-RCLPFLIT 1247

Query: 941  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1000
            ++                    E S YINA+ + SY +P   I  Q PL  T+ DFW+++
Sbjct: 1248 ID-------------------GESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLV 1288

Query: 1001 FQRKVKVIVMLTELKHGDQEICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1059
                   +VML ++     ++C QYW E G   +G I+V+    D       R+F + ++
Sbjct: 1289 LDYHCTSVVMLNDV--DPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNA 1346

Query: 1060 KRKDS--RTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1116
             R     R V Q+Q+  W +    P   +  + +I+ V +   + N  EG         +
Sbjct: 1347 ARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGR-------TV 1399

Query: 1117 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV 1174
            +HC +G  ++G FCA+  + E    +  VD+F  VK LR  +P MV   +QY+F Y+V
Sbjct: 1400 VHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEV 1457



 Score =  160 bits (405), Expect = 7e-39
 Identities = 94/306 (30%), Positives = 158/306 (51%), Gaps = 38/306 (12%)

Query: 915  QEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM 974
            ++EN+ KNR  N+I YD++RV L               ++ + D++S+    YIN ++I 
Sbjct: 933  KDENRMKNRYGNIIAYDHSRVRL---------------QTIEGDTNSD----YINGNYID 973

Query: 975  SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG 1034
             Y +P   IA QGP++ETI DFW+M++      I+M+T L    +  C +YW +  + Y 
Sbjct: 974  GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK 1033

Query: 1035 DIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVV 1094
            DI+V L +T+  + Y +R F +      + R + Q+ +T W    +P     L+  ++ V
Sbjct: 1034 DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1093

Query: 1095 KQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKAL 1154
            K K P            + PL++HC  G+ +TG F  +  +L+ AE E VVDI+  V+ L
Sbjct: 1094 KSKSPPS----------AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVREL 1143

Query: 1155 RKARPGMVSTFEQYQFLYDVIA-------STYPAQNGQVKKNNHQEDKIEFDNEVDKVKQ 1207
            R  R  MV T EQY F++D I        ++ PA   QV+   +  +K++      ++K+
Sbjct: 1144 RSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPA--SQVRSLYYDMNKLDPQTNSSQIKE 1201

Query: 1208 DANCVN 1213
            +   +N
Sbjct: 1202 EFRTLN 1207



 Score =  127 bits (318), Expect = 9e-29
 Identities = 89/269 (33%), Positives = 130/269 (48%), Gaps = 13/269 (4%)

Query: 606  EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 662
            EF+++  V     +++   A  P N  KNR +DILP D     L  I+G++ SNYINA+ 
Sbjct: 1202 EFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAAL 1260

Query: 663  IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 722
            +D +K+P  +I  Q P   TV DFWR++ +   T +VM+   +      C +YWP  E G
Sbjct: 1261 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWP--ENG 1316

Query: 723  TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHL 780
                G + V+        D I +   I N      G R V   QF  WP +   P     
Sbjct: 1317 VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRS 1376

Query: 781  LLKLRRRVNAFSNFFSGP---IVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 837
             LKL R+V+ +   ++G     VVHC  G GR+GT+  I  + E L  +  VDV+  V  
Sbjct: 1377 FLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKT 1436

Query: 838  LRRQRCLMVQVEAQYILIHQALVEYNQFG 866
            LR  +  MV +  QY   ++  +EY   G
Sbjct: 1437 LRNNKPNMVDLLDQYKFCYEVALEYLNSG 1465


>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
            [Homo sapiens]
          Length = 1440

 Score =  337 bits (864), Expect = 4e-92
 Identities = 210/561 (37%), Positives = 293/561 (52%), Gaps = 42/561 (7%)

Query: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681
            A+K  N+ KNRY +I+ YD++RV L  +  D  S+YINA+YIDG++ P  YIA QGP  E
Sbjct: 906  AKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHE 965

Query: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741
            TV DFWRMIW++++  IVMVT   E  R KC +YWP   + T  +GD  V   + +   +
Sbjct: 966  TVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFKVTCVEMEPLAE 1022

Query: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVV 801
            Y+++   +  +      REV    FT WPDHGVP     LL   RRV   +   +GPIVV
Sbjct: 1023 YVVRTFTLERRGYNEI-REVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVV 1081

Query: 802  HCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVE 861
            HCSAG GRTG YI ID ML+  E E  VD+Y  V  LR +R  MVQ E QYI IH A++E
Sbjct: 1082 HCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE 1141

Query: 862  YNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ----HIGNQEE 917
                GET + + E      +M + D  +  S L+ EFQ L S    R Q     I     
Sbjct: 1142 ACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTP-RLQAEDCSIACLPR 1200

Query: 918  NKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYW 977
            N  KNR  +++P D   +P    ++                    E S YINA+ + SY 
Sbjct: 1201 NHDKNRFMDMLPPD-RCLPFLITID-------------------GESSNYINAALMDSYR 1240

Query: 978  KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDI 1036
            +P   I  Q PL  T+ DFW++++      IVML E+     + C QYW  EG   YG I
Sbjct: 1241 QPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPI 1298

Query: 1037 EVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKELISMIQV 1093
            +V+            R+F + +  R       V Q+QY  W S  ++P   +  + +I  
Sbjct: 1299 QVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQ 1358

Query: 1094 VKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKA 1153
            V++   +    EG         +IHC +G  ++G+FCA+  ++E  + + VVD+F  VK 
Sbjct: 1359 VEKWQEECEEGEGR-------TIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKT 1411

Query: 1154 LRKARPGMVSTFEQYQFLYDV 1174
            LR ++P MV   EQY+F YDV
Sbjct: 1412 LRNSKPNMVEAPEQYRFCYDV 1432



 Score =  163 bits (412), Expect = 1e-39
 Identities = 100/306 (32%), Positives = 158/306 (51%), Gaps = 34/306 (11%)

Query: 870  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 929
            + +++L  +++ MK  D        E+ F+   +  SW    +  +++N++KNR  N+I 
Sbjct: 868  IRVADLLQHINLMKTSDSYGFKEEYESFFEGQSA--SW---DVAKKDQNRAKNRYGNIIA 922

Query: 930  YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPL 989
            YD++RV L+           + D SSD          YINA++I  Y +P   IA QGP+
Sbjct: 923  YDHSRVILQPV---------EDDPSSD----------YINANYIDGYQRPSHYIATQGPV 963

Query: 990  KETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTY 1049
             ET+ DFW+MI+Q +   IVM+T L    +  C +YW +  + YGD +V   + +  + Y
Sbjct: 964  HETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEY 1023

Query: 1050 TLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKH 1109
             +R F L      + R V Q+ +T W    +P     L+S I+ VK   P          
Sbjct: 1024 VVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPS-------- 1075

Query: 1110 HKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQ 1169
              + P+++HC  G+ +TG +  +  +L+ AE E VVDI+  VKALR  R  MV T EQY 
Sbjct: 1076 --AGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYI 1133

Query: 1170 FLYDVI 1175
            F++D I
Sbjct: 1134 FIHDAI 1139



 Score =  122 bits (306), Expect = 2e-27
 Identities = 84/265 (31%), Positives = 130/265 (49%), Gaps = 13/265 (4%)

Query: 606  EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 662
            EFQ++  V  +   ++   A  P N +KNR++D+LP D     L  I+G++ SNYINA+ 
Sbjct: 1177 EFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGES-SNYINAAL 1235

Query: 663  IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 722
            +D +++P  +I  Q P   TV DFWR++++   T IVM+   +      C +YWP  EEG
Sbjct: 1236 MDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQG--CPQYWP--EEG 1291

Query: 723  TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGR-EVTHIQFTSWPDHG-VPEDPHL 780
               +G + V+        D I +   I N      G   V   Q+  W  H  VP     
Sbjct: 1292 MLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRS 1351

Query: 781  LLKLRRRVNAFSNFFS---GPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 837
             LKL  +V  +        G  ++HC  G GR+G +  I  ++E ++ +N VDV+  V  
Sbjct: 1352 FLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKT 1411

Query: 838  LRRQRCLMVQVEAQYILIHQALVEY 862
            LR  +  MV+   QY   +   +EY
Sbjct: 1412 LRNSKPNMVEAPEQYRFCYDVALEY 1436



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 26/106 (24%), Positives = 47/106 (44%), Gaps = 9/106 (8%)

Query: 371 NFTLCYI-----KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAM 425
           N T+CY       E++ DCL++D    ++ + +L PYT   L +   I+   +    +  
Sbjct: 424 NVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKM---ILTNPEGRKESEE 480

Query: 426 CHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDRNGPHERYHL 470
               T    P  V   ++  TS +N + +  + P D NG   +Y +
Sbjct: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEI 526


>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
            [Homo sapiens]
          Length = 1446

 Score =  330 bits (847), Expect = 4e-90
 Identities = 210/567 (37%), Positives = 293/567 (51%), Gaps = 48/567 (8%)

Query: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYID------GFKEPRKYIAA 675
            A+K  N+ KNRY +I+ YD++RV L  +  D  S+YINA+YID      G++ P  YIA 
Sbjct: 906  AKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIAT 965

Query: 676  QGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQ 735
            QGP  ETV DFWRMIW++++  IVMVT   E  R KC +YWP   + T  +GD  V   +
Sbjct: 966  QGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFKVTCVE 1022

Query: 736  HKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFF 795
             +   +Y+++   +  +      REV    FT WPDHGVP     LL   RRV   +   
Sbjct: 1023 MEPLAEYVVRTFTLERRGYNEI-REVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPS 1081

Query: 796  SGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILI 855
            +GPIVVHCSAG GRTG YI ID ML+  E E  VD+Y  V  LR +R  MVQ E QYI I
Sbjct: 1082 AGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFI 1141

Query: 856  HQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ----H 911
            H A++E    GET + + E      +M + D  +  S L+ EFQ L S    R Q     
Sbjct: 1142 HDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTP-RLQAEDCS 1200

Query: 912  IGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINAS 971
            I     N  KNR  +++P D   +P    ++                    E S YINA+
Sbjct: 1201 IACLPRNHDKNRFMDMLPPD-RCLPFLITID-------------------GESSNYINAA 1240

Query: 972  FIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGK 1030
             + SY +P   I  Q PL  T+ DFW++++      IVML E+     + C QYW  EG 
Sbjct: 1241 LMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGM 1298

Query: 1031 QTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKEL 1087
              YG I+V+            R+F + +  R       V Q+QY  W S  ++P   +  
Sbjct: 1299 LRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSF 1358

Query: 1088 ISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDI 1147
            + +I  V++   +    EG         +IHC +G  ++G+FCA+  ++E  + + VVD+
Sbjct: 1359 LKLILQVEKWQEECEEGEGR-------TIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDV 1411

Query: 1148 FQVVKALRKARPGMVSTFEQYQFLYDV 1174
            F  VK LR ++P MV   EQY+F YDV
Sbjct: 1412 FHAVKTLRNSKPNMVEAPEQYRFCYDV 1438



 Score =  156 bits (395), Expect = 1e-37
 Identities = 100/312 (32%), Positives = 158/312 (50%), Gaps = 40/312 (12%)

Query: 870  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIP 929
            + +++L  +++ MK  D        E+ F+   +  SW    +  +++N++KNR  N+I 
Sbjct: 868  IRVADLLQHINLMKTSDSYGFKEEYESFFEGQSA--SW---DVAKKDQNRAKNRYGNIIA 922

Query: 930  YDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM------SYWKPEVMI 983
            YD++RV L+           + D SSD          YINA++I        Y +P   I
Sbjct: 923  YDHSRVILQPV---------EDDPSSD----------YINANYIDIWLYRDGYQRPSHYI 963

Query: 984  AAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDT 1043
            A QGP+ ET+ DFW+MI+Q +   IVM+T L    +  C +YW +  + YGD +V   + 
Sbjct: 964  ATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEM 1023

Query: 1044 DKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNS 1103
            +  + Y +R F L      + R V Q+ +T W    +P     L+S I+ VK   P    
Sbjct: 1024 EPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPS-- 1081

Query: 1104 SEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVS 1163
                    + P+++HC  G+ +TG +  +  +L+ AE E VVDI+  VKALR  R  MV 
Sbjct: 1082 --------AGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQ 1133

Query: 1164 TFEQYQFLYDVI 1175
            T EQY F++D I
Sbjct: 1134 TEEQYIFIHDAI 1145



 Score =  122 bits (306), Expect = 2e-27
 Identities = 84/265 (31%), Positives = 130/265 (49%), Gaps = 13/265 (4%)

Query: 606  EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 662
            EFQ++  V  +   ++   A  P N +KNR++D+LP D     L  I+G++ SNYINA+ 
Sbjct: 1183 EFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGES-SNYINAAL 1241

Query: 663  IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 722
            +D +++P  +I  Q P   TV DFWR++++   T IVM+   +      C +YWP  EEG
Sbjct: 1242 MDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQG--CPQYWP--EEG 1297

Query: 723  TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGR-EVTHIQFTSWPDHG-VPEDPHL 780
               +G + V+        D I +   I N      G   V   Q+  W  H  VP     
Sbjct: 1298 MLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRS 1357

Query: 781  LLKLRRRVNAFSNFFS---GPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 837
             LKL  +V  +        G  ++HC  G GR+G +  I  ++E ++ +N VDV+  V  
Sbjct: 1358 FLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKT 1417

Query: 838  LRRQRCLMVQVEAQYILIHQALVEY 862
            LR  +  MV+   QY   +   +EY
Sbjct: 1418 LRNSKPNMVEAPEQYRFCYDVALEY 1442



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 26/106 (24%), Positives = 47/106 (44%), Gaps = 9/106 (8%)

Query: 371 NFTLCYI-----KETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAM 425
           N T+CY       E++ DCL++D    ++ + +L PYT   L +   I+   +    +  
Sbjct: 424 NVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKM---ILTNPEGRKESEE 480

Query: 426 CHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDRNGPHERYHL 470
               T    P  V   ++  TS +N + +  + P D NG   +Y +
Sbjct: 481 TIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEI 526


>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
            precursor [Homo sapiens]
          Length = 2315

 Score =  322 bits (826), Expect = 1e-87
 Identities = 211/680 (31%), Positives = 338/680 (49%), Gaps = 72/680 (10%)

Query: 529  LIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHAD-- 586
            +++ L F+ +V  + +L+   K +     ++ +   +     R        + PI  D  
Sbjct: 1643 IVSALTFICLVVLVGILIYWRKCF-----QTAHFYLEDSTSPRVISTPPTPIFPISDDVG 1697

Query: 587  -ILLETYKRKIAD--EGRLFLAEFQSIPRVFSK---------FPIKEARKPFNQNKNRYV 634
             I ++ + + +AD      F  EF+++   + +              +  P N++KNRY+
Sbjct: 1698 AIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYI 1757

Query: 635  DILPYDYNRVELSEINGDAG--SNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWE 692
            +I+ YD++RV+L+++    G  ++YINA+Y+DG+  P+ YIAAQGP   T +DFWRMIWE
Sbjct: 1758 NIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWE 1817

Query: 693  QKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNK 752
                VIVM+T   E  R KC +YWP+  +G+  +G+ +V     +    Y ++   + N 
Sbjct: 1818 HNVEVIVMITNLVEKGRRKCDQYWPA--DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNT 1875

Query: 753  KEKA-------TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSA 805
            K K        +GR VT   +T WPD GVPE    +L   R+         GP+VVHCSA
Sbjct: 1876 KIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSA 1935

Query: 806  GVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQF 865
            GVGRTGTYI +D+ML+ ++ E  V+++G++  +R QR  +VQ E QY+ IH  LVE    
Sbjct: 1936 GVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS 1995

Query: 866  GETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEE-NKSKNRN 924
             ETEV  S +H Y+ N      P+  + LE +FQ L      ++ +    ++ N+ KNR 
Sbjct: 1996 KETEVLDSHIHAYV-NALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRT 2054

Query: 925  SNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIA 984
            S++IP + +RV +                     S S E + YINAS+IM Y++    I 
Sbjct: 2055 SSIIPVERSRVGI--------------------SSLSGEGTDYINASYIMGYYQSNEFII 2094

Query: 985  AQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG--DIEVDL-- 1040
             Q PL  TI DFW+MI+    +++VM+ + ++  ++    YW    +       +V L  
Sbjct: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV-YWPNKDEPINCESFKVTLMA 2153

Query: 1041 ---KDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQK 1097
               K         ++ F L  ++      V  +Q   W     P    +   +I V+K++
Sbjct: 2154 EEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPI--SKTFELISVIKEE 2211

Query: 1098 LPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKA 1157
               ++           P+++H   G    G FCAL  L+   E E  VD++QV K +   
Sbjct: 2212 AANRDG----------PMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLM 2261

Query: 1158 RPGMVSTFEQYQFLYDVIAS 1177
            RPG+ +  EQYQFLY VI S
Sbjct: 2262 RPGVFADIEQYQFLYKVILS 2281



 Score =  150 bits (380), Expect = 6e-36
 Identities = 92/287 (32%), Positives = 145/287 (50%), Gaps = 36/287 (12%)

Query: 909  TQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYI 968
            T    N  +NK KNR  N++ YD++RV L      ++ +E D            + + YI
Sbjct: 1741 TADSSNHPDNKHKNRYINIVAYDHSRVKL------AQLAEKDG-----------KLTDYI 1783

Query: 969  NASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-G 1027
            NA+++  Y +P+  IAAQGPLK T  DFW+MI++  V+VIVM+T L    +  C QYW  
Sbjct: 1784 NANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA 1843

Query: 1028 EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSK--------RKDSRTVYQYQYTNWSVEQ 1079
            +G + YG+  V  K     + YT+R F LR++K        R   R V QY YT W    
Sbjct: 1844 DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMG 1903

Query: 1080 LPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESA 1139
            +P     +++ ++               K H   P+++HC  G  +TG +  L ++L+  
Sbjct: 1904 VPEYSLPVLTFVRKAAYA----------KRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQI 1953

Query: 1140 ETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1186
            + E  V+IF  +K +R  R  +V T EQY F++D +     ++  +V
Sbjct: 1954 QHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV 2000


>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
            precursor [Homo sapiens]
          Length = 1436

 Score =  317 bits (812), Expect = 5e-86
 Identities = 208/599 (34%), Positives = 302/599 (50%), Gaps = 49/599 (8%)

Query: 585  ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP-YDYNR 643
            AD+L    + K A EG  F  E++S       F   +A K  ++ K    + +P YD +R
Sbjct: 867  ADLLQHINQMKTA-EGYGFKQEYESF------FEGWDATKKKDKVKGSRQEPMPAYDRHR 919

Query: 644  VELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTR 703
            V+L  + GD  ++YINA+YIDG+     +IA QGP+ E V DFWRM+W++  + IVM+T+
Sbjct: 920  VKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITK 979

Query: 704  CEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTH 763
              E  R KC+ YWP   E +  +GD+ + + + +   +Y+++   +  +   A   EV  
Sbjct: 980  LVEVGRVKCSRYWP---EDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR-HEVRQ 1035

Query: 764  IQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGL 823
              FT+WP+HGVP     LL   RRV A +   +GPIV+HCSAG GRTG YI +D ML+  
Sbjct: 1036 FHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMA 1095

Query: 824  EAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMK 883
            E E  VD+Y  V  L  +R  M+Q E QYI IH A++E    GET + +SE       M 
Sbjct: 1096 ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMI 1155

Query: 884  KRDPPSEPSPLEAEFQRLPSYR---SWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHE 940
            + DP S  S L  EFQ L S           I     N+ KNR+ +V+P D   +P    
Sbjct: 1156 RIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD-RCLPFL-- 1212

Query: 941  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1000
                         S+D DS++     YINA+   SY +    I    PL+ T  DFW+++
Sbjct: 1213 ------------ISTDGDSNN-----YINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLV 1255

Query: 1001 FQRKVKVIVMLTELKHGDQE-ICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRH 1058
            +      IVML +L   +    C QYW E G+Q YG +EV+            RVF +++
Sbjct: 1256 YDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQN 1315

Query: 1059 SKR--KDSRTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPL 1115
              R  +    V  +Q+  WS     P   K  + ++  V +   Q  S +G         
Sbjct: 1316 ISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKW--QAESGDGR-------T 1366

Query: 1116 LIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV 1174
            ++HC +G  ++G FCA   +LE      +VD+F   K LR  +P MV T +QY F YDV
Sbjct: 1367 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDV 1425



 Score =  137 bits (344), Expect = 8e-32
 Identities = 88/273 (32%), Positives = 132/273 (48%), Gaps = 30/273 (10%)

Query: 904  YRSWRTQHIGNQEENKSKNRNSNVIP-YDYNRVPLKHELEMSKESEHDSDESSDDDSDSE 962
            Y S+       ++++K K      +P YD +RV L   L              D ++D  
Sbjct: 888  YESFFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPML-------------GDPNAD-- 932

Query: 963  EPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEIC 1022
                YINA++I  Y +    IA QGP  E + DFW+M++Q     IVM+T+L    +  C
Sbjct: 933  ----YINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKC 988

Query: 1023 AQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPA 1082
            ++YW E   TYGDI++ L  T+  + Y +R F L          V Q+ +T W    +P 
Sbjct: 989  SRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPY 1048

Query: 1083 EPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETE 1142
                L++ I+ VK   P            + P++IHC  G+ +TG +  L  +L+ AE E
Sbjct: 1049 HATGLLAFIRRVKASTPPD----------AGPIVIHCSAGTGRTGCYIVLDVMLDMAECE 1098

Query: 1143 EVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI 1175
             VVDI+  VK L   R  M+ T EQY F++D I
Sbjct: 1099 GVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAI 1131



 Score =  114 bits (285), Expect = 6e-25
 Identities = 97/363 (26%), Positives = 151/363 (41%), Gaps = 18/363 (4%)

Query: 515  PFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNL--DEQQELVERD 572
            P ++H S           L  ++ +     +V +Y        R  N+   E+Q +   D
Sbjct: 1070 PIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHD 1129

Query: 573  D--EKQLMNVEPIHADILLETYKRKIA----DEGRLFLAEFQSIPRVFSKFPIKE---AR 623
               E  L     I       TYK  I             EFQ++  V     ++E   A 
Sbjct: 1130 AILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIAL 1189

Query: 624  KPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETV 683
             P N++KNR +D+LP D     L   +GD+ +NYINA+  D +     +I    P   T 
Sbjct: 1190 LPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTT 1248

Query: 684  DDFWRMIWEQKATVIVMVTRCEEGNRN-KCAEYWPSMEEGTRAFGDVVVKINQHKRCPDY 742
             DFWR++++   T IVM+ +  + N    C +YWP  E G + +G + V+        D 
Sbjct: 1249 PDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWP--EPGRQQYGLMEVEFMSGTADEDL 1306

Query: 743  IIQKLNIVNKKEKATGRE-VTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAF-SNFFSGPI 799
            + +   + N      G   V H QF  W  +   P+     L L   V+ + +    G  
Sbjct: 1307 VARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRT 1366

Query: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
            +VHC  G GR+GT+     +LE +   N VDV+     LR  +  MV+   QY   +   
Sbjct: 1367 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1426

Query: 860  VEY 862
            +EY
Sbjct: 1427 LEY 1429



 Score = 35.0 bits (79), Expect = 0.45
 Identities = 50/212 (23%), Positives = 82/212 (38%), Gaps = 31/212 (14%)

Query: 288 ITYRFQCGNMIFDNKEIKLENLEPEHEYKCD--SEILYNNHKFTNASKIIKTDFGSPGEP 345
           + YR     ++  N E + E  E   +   D  S I   +  FT    +I   +  P EP
Sbjct: 454 LPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513

Query: 346 QIIFCRSEAAHQGVITWNP------PQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNL 399
             +  + E ++Q + + +P      P+R+                    +N   +   NL
Sbjct: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKL----------------RNETYHVFSNL 557

Query: 400 KPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-SAPPSQVWNMTVSM-TSDNSMHVKCRP 457
            P T Y+ S+ A      +  G AA+   TT  SAP     +M   +  S+N++ V  RP
Sbjct: 558 HPGTTYLFSVRA---RTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRP 614

Query: 458 PRDRNGPHERYH--LEVEAGNTLVRNESHKNC 487
            + R  P   Y   +E E    L R    ++C
Sbjct: 615 AQGRGAPISVYQVIVEEERARRLRREPGGQDC 646



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 27/133 (20%), Positives = 58/133 (43%), Gaps = 16/133 (12%)

Query: 355 AHQGVITWNPPQRSF---HNFT--LCYI-------KETEKDCLNLDKNLIKYDLQNLKPY 402
           A Q  + W P   +    H +T  LCY         +T ++C+  ++ + +Y ++NL PY
Sbjct: 397 ARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPY 456

Query: 403 TKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDR 461
               + L   ++   +         F T    PS +   +++ T  ++ + +K   P++ 
Sbjct: 457 RNVHVRL---VLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513

Query: 462 NGPHERYHLEVEA 474
           NG   +Y +  ++
Sbjct: 514 NGLITQYEISYQS 526


>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
            precursor [Homo sapiens]
          Length = 1446

 Score =  317 bits (812), Expect = 5e-86
 Identities = 208/599 (34%), Positives = 302/599 (50%), Gaps = 49/599 (8%)

Query: 585  ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP-YDYNR 643
            AD+L    + K A EG  F  E++S       F   +A K  ++ K    + +P YD +R
Sbjct: 877  ADLLQHINQMKTA-EGYGFKQEYESF------FEGWDATKKKDKVKGSRQEPMPAYDRHR 929

Query: 644  VELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTR 703
            V+L  + GD  ++YINA+YIDG+     +IA QGP+ E V DFWRM+W++  + IVM+T+
Sbjct: 930  VKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITK 989

Query: 704  CEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTH 763
              E  R KC+ YWP   E +  +GD+ + + + +   +Y+++   +  +   A   EV  
Sbjct: 990  LVEVGRVKCSRYWP---EDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR-HEVRQ 1045

Query: 764  IQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGL 823
              FT+WP+HGVP     LL   RRV A +   +GPIV+HCSAG GRTG YI +D ML+  
Sbjct: 1046 FHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMA 1105

Query: 824  EAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMK 883
            E E  VD+Y  V  L  +R  M+Q E QYI IH A++E    GET + +SE       M 
Sbjct: 1106 ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMI 1165

Query: 884  KRDPPSEPSPLEAEFQRLPSYR---SWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHE 940
            + DP S  S L  EFQ L S           I     N+ KNR+ +V+P D   +P    
Sbjct: 1166 RIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD-RCLPFL-- 1222

Query: 941  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1000
                         S+D DS++     YINA+   SY +    I    PL+ T  DFW+++
Sbjct: 1223 ------------ISTDGDSNN-----YINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLV 1265

Query: 1001 FQRKVKVIVMLTELKHGDQE-ICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRH 1058
            +      IVML +L   +    C QYW E G+Q YG +EV+            RVF +++
Sbjct: 1266 YDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQN 1325

Query: 1059 SKR--KDSRTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPL 1115
              R  +    V  +Q+  WS     P   K  + ++  V +   Q  S +G         
Sbjct: 1326 ISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKW--QAESGDGR-------T 1376

Query: 1116 LIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV 1174
            ++HC +G  ++G FCA   +LE      +VD+F   K LR  +P MV T +QY F YDV
Sbjct: 1377 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDV 1435



 Score =  137 bits (344), Expect = 8e-32
 Identities = 88/273 (32%), Positives = 132/273 (48%), Gaps = 30/273 (10%)

Query: 904  YRSWRTQHIGNQEENKSKNRNSNVIP-YDYNRVPLKHELEMSKESEHDSDESSDDDSDSE 962
            Y S+       ++++K K      +P YD +RV L   L              D ++D  
Sbjct: 898  YESFFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPML-------------GDPNAD-- 942

Query: 963  EPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEIC 1022
                YINA++I  Y +    IA QGP  E + DFW+M++Q     IVM+T+L    +  C
Sbjct: 943  ----YINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKC 998

Query: 1023 AQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPA 1082
            ++YW E   TYGDI++ L  T+  + Y +R F L          V Q+ +T W    +P 
Sbjct: 999  SRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPY 1058

Query: 1083 EPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETE 1142
                L++ I+ VK   P            + P++IHC  G+ +TG +  L  +L+ AE E
Sbjct: 1059 HATGLLAFIRRVKASTPPD----------AGPIVIHCSAGTGRTGCYIVLDVMLDMAECE 1108

Query: 1143 EVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI 1175
             VVDI+  VK L   R  M+ T EQY F++D I
Sbjct: 1109 GVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAI 1141



 Score =  114 bits (285), Expect = 6e-25
 Identities = 97/363 (26%), Positives = 151/363 (41%), Gaps = 18/363 (4%)

Query: 515  PFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNL--DEQQELVERD 572
            P ++H S           L  ++ +     +V +Y        R  N+   E+Q +   D
Sbjct: 1080 PIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHD 1139

Query: 573  D--EKQLMNVEPIHADILLETYKRKIA----DEGRLFLAEFQSIPRVFSKFPIKE---AR 623
               E  L     I       TYK  I             EFQ++  V     ++E   A 
Sbjct: 1140 AILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIAL 1199

Query: 624  KPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETV 683
             P N++KNR +D+LP D     L   +GD+ +NYINA+  D +     +I    P   T 
Sbjct: 1200 LPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTT 1258

Query: 684  DDFWRMIWEQKATVIVMVTRCEEGNRN-KCAEYWPSMEEGTRAFGDVVVKINQHKRCPDY 742
             DFWR++++   T IVM+ +  + N    C +YWP  E G + +G + V+        D 
Sbjct: 1259 PDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWP--EPGRQQYGLMEVEFMSGTADEDL 1316

Query: 743  IIQKLNIVNKKEKATGRE-VTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAF-SNFFSGPI 799
            + +   + N      G   V H QF  W  +   P+     L L   V+ + +    G  
Sbjct: 1317 VARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRT 1376

Query: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
            +VHC  G GR+GT+     +LE +   N VDV+     LR  +  MV+   QY   +   
Sbjct: 1377 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1436

Query: 860  VEY 862
            +EY
Sbjct: 1437 LEY 1439



 Score = 35.0 bits (79), Expect = 0.45
 Identities = 50/212 (23%), Positives = 82/212 (38%), Gaps = 31/212 (14%)

Query: 288 ITYRFQCGNMIFDNKEIKLENLEPEHEYKCD--SEILYNNHKFTNASKIIKTDFGSPGEP 345
           + YR     ++  N E + E  E   +   D  S I   +  FT    +I   +  P EP
Sbjct: 454 LPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513

Query: 346 QIIFCRSEAAHQGVITWNP------PQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNL 399
             +  + E ++Q + + +P      P+R+                    +N   +   NL
Sbjct: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKL----------------RNETYHVFSNL 557

Query: 400 KPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-SAPPSQVWNMTVSM-TSDNSMHVKCRP 457
            P T Y+ S+ A      +  G AA+   TT  SAP     +M   +  S+N++ V  RP
Sbjct: 558 HPGTTYLFSVRA---RTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRP 614

Query: 458 PRDRNGPHERYH--LEVEAGNTLVRNESHKNC 487
            + R  P   Y   +E E    L R    ++C
Sbjct: 615 AQGRGAPISVYQVIVEEERARRLRREPGGQDC 646



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 27/133 (20%), Positives = 58/133 (43%), Gaps = 16/133 (12%)

Query: 355 AHQGVITWNPPQRSF---HNFT--LCYI-------KETEKDCLNLDKNLIKYDLQNLKPY 402
           A Q  + W P   +    H +T  LCY         +T ++C+  ++ + +Y ++NL PY
Sbjct: 397 ARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPY 456

Query: 403 TKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDR 461
               + L   ++   +         F T    PS +   +++ T  ++ + +K   P++ 
Sbjct: 457 RNVHVRL---VLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513

Query: 462 NGPHERYHLEVEA 474
           NG   +Y +  ++
Sbjct: 514 NGLITQYEISYQS 526


>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
            [Homo sapiens]
          Length = 1445

 Score =  315 bits (806), Expect = 2e-85
 Identities = 201/598 (33%), Positives = 307/598 (51%), Gaps = 59/598 (9%)

Query: 603  FLAEFQSIPRVFSKFPI--KEARKPFNQNKNRYVDILPYDYNRVELSEINGDAG--SNYI 658
            F  +F+ + R  +   I  + +  P N++KNRY++IL YD++RV+L  + G     S+YI
Sbjct: 848  FSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYI 907

Query: 659  NASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPS 718
            NA+Y+DG+ + + YIA QGP   T +DFWRMIWEQ   +IVM+T   E  R KC +YWP+
Sbjct: 908  NANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPT 967

Query: 719  MEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA----------TGREVTHIQFTS 768
              E +  +G+++V +   K    Y +++ +I N K K             R V    +T 
Sbjct: 968  --ENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQ 1025

Query: 769  WPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENK 828
            WPD GVPE    +L   RR +A     +GP++VHCSAGVGRTGTYI ID+ML+ ++ ++ 
Sbjct: 1026 WPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKST 1085

Query: 829  VDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPP 888
            V+V G++  +R QR  +VQ E QYI IH AL+E     ETEV+ ++LH Y++++      
Sbjct: 1086 VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVG 1145

Query: 889  SEPSPLEAEFQRLPSYRSWRTQHIGNQEE-NKSKNRNSNVIPYDYNRVPLKHELEMSKES 947
             + + LE +F+ +    +   +    Q+E NK KNRNS+V+P +  RV L     M    
Sbjct: 1146 GK-TRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGM---- 1200

Query: 948  EHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKV 1007
                           + + YINAS+IM Y++    I  Q PL  T  DFW+MI+    ++
Sbjct: 1201 ---------------KGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQI 1245

Query: 1008 IVMLTELKH-GDQEICAQYWGEGKQ-------TYGDIEVDLKDTDKSSTYTLRVFELRHS 1059
            IVML + +   + E    YW   ++       T   I  D           +  F L  +
Sbjct: 1246 IVMLPDNQSLAEDEFV--YWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEAT 1303

Query: 1060 KRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHC 1119
            +      V  +Q   W     P        +I V+K++   ++           P ++H 
Sbjct: 1304 QDDYVLEVRHFQCPKWPNPDAPI--SSTFELINVIKEEALTRDG----------PTIVHD 1351

Query: 1120 RDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIAS 1177
              G+   G+ CAL  L +  E E  VD+FQV K +   RPG+ +  EQYQF+Y  + S
Sbjct: 1352 EYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS 1409



 Score =  150 bits (380), Expect = 6e-36
 Identities = 94/305 (30%), Positives = 153/305 (50%), Gaps = 40/305 (13%)

Query: 897  EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 956
            E QR  +  +   +H  N  ENK KNR  N++ YD++RV L+      K+S+H       
Sbjct: 854  EVQRCTADMNITAEH-SNHPENKHKNRYINILAYDHSRVKLRPL--PGKDSKH------- 903

Query: 957  DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 1016
                    S YINA+++  Y K +  IA QGPLK T  DFW+MI+++   +IVM+T L  
Sbjct: 904  --------SDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVE 955

Query: 1017 GDQEICAQYWG-EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSK-----------RKDS 1064
              +  C QYW  E  + YG+I V LK T   + YT+R F +R++K           R++ 
Sbjct: 956  KGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNE 1015

Query: 1065 RTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQ 1124
            R V QY YT W    +P     +++ ++           S   +  ++ P+L+HC  G  
Sbjct: 1016 RVVIQYHYTQWPDMGVPEYALPVLTFVR----------RSSAARMPETGPVLVHCSAGVG 1065

Query: 1125 QTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNG 1184
            +TG +  + ++L+  + +  V++   +K +R  R  +V T EQY F++D +      +  
Sbjct: 1066 RTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET 1125

Query: 1185 QVKKN 1189
            +V  N
Sbjct: 1126 EVSSN 1130


>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
            precursor [Homo sapiens]
          Length = 1442

 Score =  310 bits (795), Expect = 4e-84
 Identities = 208/605 (34%), Positives = 302/605 (49%), Gaps = 55/605 (9%)

Query: 585  ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP-YDYNR 643
            AD+L    + K A EG  F  E++S       F   +A K  ++ K    + +P YD +R
Sbjct: 867  ADLLQHINQMKTA-EGYGFKQEYESF------FEGWDATKKKDKVKGSRQEPMPAYDRHR 919

Query: 644  VELSEINGDAGSNYINASYID------GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATV 697
            V+L  + GD  ++YINA+YID      G+     +IA QGP+ E V DFWRM+W++  + 
Sbjct: 920  VKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSS 979

Query: 698  IVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKAT 757
            IVM+T+  E  R KC+ YWP   E +  +GD+ + + + +   +Y+++   +  +   A 
Sbjct: 980  IVMITKLVEVGRVKCSRYWP---EDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR 1036

Query: 758  GREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGID 817
              EV    FT+WP+HGVP     LL   RRV A +   +GPIV+HCSAG GRTG YI +D
Sbjct: 1037 -HEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLD 1095

Query: 818  AMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHP 877
             ML+  E E  VD+Y  V  L  +R  M+Q E QYI IH A++E    GET + +SE   
Sbjct: 1096 VMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKA 1155

Query: 878  YLHNMKKRDPPSEPSPLEAEFQRLPSYR---SWRTQHIGNQEENKSKNRNSNVIPYDYNR 934
                M + DP S  S L  EFQ L S           I     N+ KNR+ +V+P D   
Sbjct: 1156 TYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD-RC 1214

Query: 935  VPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIG 994
            +P                 S+D DS++     YINA+   SY +    I    PL+ T  
Sbjct: 1215 LPFL--------------ISTDGDSNN-----YINAALTDSYTRSAAFIVTLHPLQSTTP 1255

Query: 995  DFWQMIFQRKVKVIVMLTELKHGDQE-ICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLR 1052
            DFW++++      IVML +L   +    C QYW E G+Q YG +EV+            R
Sbjct: 1256 DFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVAR 1315

Query: 1053 VFELRHSKR--KDSRTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKH 1109
            VF +++  R  +    V  +Q+  WS     P   K  + ++  V +   Q  S +G   
Sbjct: 1316 VFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKW--QAESGDGR-- 1371

Query: 1110 HKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQ 1169
                  ++HC +G  ++G FCA   +LE      +VD+F   K LR  +P MV T +QY 
Sbjct: 1372 -----TIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYH 1426

Query: 1170 FLYDV 1174
            F YDV
Sbjct: 1427 FCYDV 1431



 Score =  130 bits (328), Expect = 6e-30
 Identities = 88/279 (31%), Positives = 132/279 (47%), Gaps = 36/279 (12%)

Query: 904  YRSWRTQHIGNQEENKSKNRNSNVIP-YDYNRVPLKHELEMSKESEHDSDESSDDDSDSE 962
            Y S+       ++++K K      +P YD +RV L   L              D ++D  
Sbjct: 888  YESFFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPML-------------GDPNAD-- 932

Query: 963  EPSKYINASFI------MSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 1016
                YINA++I        Y +    IA QGP  E + DFW+M++Q     IVM+T+L  
Sbjct: 933  ----YINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVE 988

Query: 1017 GDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWS 1076
              +  C++YW E   TYGDI++ L  T+  + Y +R F L          V Q+ +T W 
Sbjct: 989  VGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWP 1048

Query: 1077 VEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLL 1136
               +P     L++ I+ VK   P            + P++IHC  G+ +TG +  L  +L
Sbjct: 1049 EHGVPYHATGLLAFIRRVKASTPPD----------AGPIVIHCSAGTGRTGCYIVLDVML 1098

Query: 1137 ESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI 1175
            + AE E VVDI+  VK L   R  M+ T EQY F++D I
Sbjct: 1099 DMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAI 1137



 Score =  114 bits (285), Expect = 6e-25
 Identities = 97/363 (26%), Positives = 151/363 (41%), Gaps = 18/363 (4%)

Query: 515  PFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNL--DEQQELVERD 572
            P ++H S           L  ++ +     +V +Y        R  N+   E+Q +   D
Sbjct: 1076 PIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHD 1135

Query: 573  D--EKQLMNVEPIHADILLETYKRKIA----DEGRLFLAEFQSIPRVFSKFPIKE---AR 623
               E  L     I       TYK  I             EFQ++  V     ++E   A 
Sbjct: 1136 AILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIAL 1195

Query: 624  KPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETV 683
             P N++KNR +D+LP D     L   +GD+ +NYINA+  D +     +I    P   T 
Sbjct: 1196 LPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTT 1254

Query: 684  DDFWRMIWEQKATVIVMVTRCEEGNRN-KCAEYWPSMEEGTRAFGDVVVKINQHKRCPDY 742
             DFWR++++   T IVM+ +  + N    C +YWP  E G + +G + V+        D 
Sbjct: 1255 PDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWP--EPGRQQYGLMEVEFMSGTADEDL 1312

Query: 743  IIQKLNIVNKKEKATGRE-VTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAF-SNFFSGPI 799
            + +   + N      G   V H QF  W  +   P+     L L   V+ + +    G  
Sbjct: 1313 VARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRT 1372

Query: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
            +VHC  G GR+GT+     +LE +   N VDV+     LR  +  MV+   QY   +   
Sbjct: 1373 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1432

Query: 860  VEY 862
            +EY
Sbjct: 1433 LEY 1435



 Score = 35.0 bits (79), Expect = 0.45
 Identities = 50/212 (23%), Positives = 82/212 (38%), Gaps = 31/212 (14%)

Query: 288 ITYRFQCGNMIFDNKEIKLENLEPEHEYKCD--SEILYNNHKFTNASKIIKTDFGSPGEP 345
           + YR     ++  N E + E  E   +   D  S I   +  FT    +I   +  P EP
Sbjct: 454 LPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513

Query: 346 QIIFCRSEAAHQGVITWNP------PQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNL 399
             +  + E ++Q + + +P      P+R+                    +N   +   NL
Sbjct: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKL----------------RNETYHVFSNL 557

Query: 400 KPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-SAPPSQVWNMTVSM-TSDNSMHVKCRP 457
            P T Y+ S+ A      +  G AA+   TT  SAP     +M   +  S+N++ V  RP
Sbjct: 558 HPGTTYLFSVRA---RTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRP 614

Query: 458 PRDRNGPHERYH--LEVEAGNTLVRNESHKNC 487
            + R  P   Y   +E E    L R    ++C
Sbjct: 615 AQGRGAPISVYQVIVEEERARRLRREPGGQDC 646



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 27/133 (20%), Positives = 58/133 (43%), Gaps = 16/133 (12%)

Query: 355 AHQGVITWNPPQRSF---HNFT--LCYI-------KETEKDCLNLDKNLIKYDLQNLKPY 402
           A Q  + W P   +    H +T  LCY         +T ++C+  ++ + +Y ++NL PY
Sbjct: 397 ARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPY 456

Query: 403 TKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDR 461
               + L   ++   +         F T    PS +   +++ T  ++ + +K   P++ 
Sbjct: 457 RNVHVRL---VLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513

Query: 462 NGPHERYHLEVEA 474
           NG   +Y +  ++
Sbjct: 514 NGLITQYEISYQS 526


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,073,227
Number of Sequences: 37866
Number of extensions: 2440600
Number of successful extensions: 15027
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 144
Number of HSP's successfully gapped in prelim test: 202
Number of HSP's that attempted gapping in prelim test: 10053
Number of HSP's gapped (non-prelim): 2325
length of query: 1256
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1142
effective length of database: 13,930,794
effective search space: 15908966748
effective search space used: 15908966748
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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