Guide to the Human Genome
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Search of human proteins with 18450369

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|18450369 protein tyrosine phosphatase, receptor type, A
isoform 2 precursor [Homo sapiens]
         (793 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|18450371 protein tyrosine phosphatase, receptor type, A isofo...  1612   0.0  
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo...  1612   0.0  
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor...  1604   0.0  
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor...   941   0.0  
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo...   924   0.0  
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...   609   e-174
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...   609   e-174
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...   601   e-172
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...   601   e-172
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...   601   e-172
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...   601   e-172
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...   598   e-171
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...   589   e-168
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...   589   e-168
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...   589   e-168
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...   587   e-167
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo...   471   e-132
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo...   471   e-132
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo...   471   e-132
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo...   441   e-123
gi|157419150 protein tyrosine phosphatase, receptor type, M isof...   440   e-123
gi|157419152 protein tyrosine phosphatase, receptor type, M isof...   440   e-123
gi|208431815 protein tyrosine phosphatase, receptor type, K isof...   435   e-122
gi|148539860 protein tyrosine phosphatase, receptor type, T isof...   434   e-121
gi|148539858 protein tyrosine phosphatase, receptor type, T isof...   434   e-121
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p...   408   e-113
gi|194097398 protein tyrosine phosphatase, receptor type, G prec...   404   e-112
gi|110735404 protein tyrosine phosphatase, receptor type, U isof...   404   e-112
gi|110735402 protein tyrosine phosphatase, receptor type, U isof...   404   e-112
gi|110735406 protein tyrosine phosphatase, receptor type, U isof...   398   e-110

>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform
           2 precursor [Homo sapiens]
          Length = 793

 Score = 1612 bits (4174), Expect = 0.0
 Identities = 793/793 (100%), Positives = 793/793 (100%)

Query: 1   MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLS 60
           MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLS
Sbjct: 1   MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLS 60

Query: 61  VAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEP 120
           VAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEP
Sbjct: 61  VAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEP 120

Query: 121 WEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNS 180
           WEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNS
Sbjct: 121 WEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNS 180

Query: 181 FRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALP 240
           FRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALP
Sbjct: 181 FRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALP 240

Query: 241 ACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNK 300
           ACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNK
Sbjct: 241 ACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNK 300

Query: 301 FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSV 360
           FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSV
Sbjct: 301 FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSV 360

Query: 361 EDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKA 420
           EDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKA
Sbjct: 361 EDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKA 420

Query: 421 CNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDM 480
           CNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDM
Sbjct: 421 CNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDM 480

Query: 481 QYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDK 540
           QYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDK
Sbjct: 481 QYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDK 540

Query: 541 MRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGP 600
           MRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGP
Sbjct: 541 MRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGP 600

Query: 601 LLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECE 660
           LLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECE
Sbjct: 601 LLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECE 660

Query: 661 SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPIT 720
           SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPIT
Sbjct: 661 SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPIT 720

Query: 721 VHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQ 780
           VHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQ
Sbjct: 721 VHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQ 780

Query: 781 EYIDAFSDYANFK 793
           EYIDAFSDYANFK
Sbjct: 781 EYIDAFSDYANFK 793


>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform
           2 precursor [Homo sapiens]
          Length = 793

 Score = 1612 bits (4174), Expect = 0.0
 Identities = 793/793 (100%), Positives = 793/793 (100%)

Query: 1   MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLS 60
           MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLS
Sbjct: 1   MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLS 60

Query: 61  VAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEP 120
           VAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEP
Sbjct: 61  VAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEP 120

Query: 121 WEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNS 180
           WEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNS
Sbjct: 121 WEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNS 180

Query: 181 FRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALP 240
           FRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALP
Sbjct: 181 FRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALP 240

Query: 241 ACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNK 300
           ACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNK
Sbjct: 241 ACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNK 300

Query: 301 FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSV 360
           FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSV
Sbjct: 301 FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSV 360

Query: 361 EDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKA 420
           EDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKA
Sbjct: 361 EDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKA 420

Query: 421 CNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDM 480
           CNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDM
Sbjct: 421 CNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDM 480

Query: 481 QYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDK 540
           QYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDK
Sbjct: 481 QYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDK 540

Query: 541 MRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGP 600
           MRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGP
Sbjct: 541 MRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGP 600

Query: 601 LLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECE 660
           LLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECE
Sbjct: 601 LLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECE 660

Query: 661 SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPIT 720
           SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPIT
Sbjct: 661 SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPIT 720

Query: 721 VHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQ 780
           VHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQ
Sbjct: 721 VHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQ 780

Query: 781 EYIDAFSDYANFK 793
           EYIDAFSDYANFK
Sbjct: 781 EYIDAFSDYANFK 793


>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
           precursor [Homo sapiens]
          Length = 802

 Score = 1604 bits (4154), Expect = 0.0
 Identities = 793/802 (98%), Positives = 793/802 (98%), Gaps = 9/802 (1%)

Query: 1   MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLS 60
           MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLS
Sbjct: 1   MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLS 60

Query: 61  VAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEP 120
           VAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEP
Sbjct: 61  VAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEP 120

Query: 121 WEGNSSTAATTPETFPPS---------DETPIIAVMVALSSLLVIVFIIIVLYMLRFKKY 171
           WEGNSSTAATTPETFPPS         DETPIIAVMVALSSLLVIVFIIIVLYMLRFKKY
Sbjct: 121 WEGNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKY 180

Query: 172 KQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKL 231
           KQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKL
Sbjct: 181 KQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKL 240

Query: 232 FREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASF 291
           FREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASF
Sbjct: 241 FREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASF 300

Query: 292 INGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCW 351
           INGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCW
Sbjct: 301 INGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCW 360

Query: 352 TYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGM 411
           TYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGM
Sbjct: 361 TYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGM 420

Query: 412 LKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQ 471
           LKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQ
Sbjct: 421 LKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQ 480

Query: 472 RCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKL 531
           RCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKL
Sbjct: 481 RCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKL 540

Query: 532 TSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQK 591
           TSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQK
Sbjct: 541 TSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQK 600

Query: 592 DSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITV 651
           DSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITV
Sbjct: 601 DSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITV 660

Query: 652 ELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQ 711
           ELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQ
Sbjct: 661 ELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQ 720

Query: 712 QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771
           QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ
Sbjct: 721 QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 780

Query: 772 YEFCYKVVQEYIDAFSDYANFK 793
           YEFCYKVVQEYIDAFSDYANFK
Sbjct: 781 YEFCYKVVQEYIDAFSDYANFK 802


>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
           precursor [Homo sapiens]
          Length = 700

 Score =  941 bits (2431), Expect = 0.0
 Identities = 464/682 (68%), Positives = 558/682 (81%), Gaps = 14/682 (2%)

Query: 123 GNSSTA---ATTPETFPPSD--ETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSH 177
           GN +TA    TT  + PP      P++A ++ L  LL+++ +++  Y  RF+K ++A   
Sbjct: 22  GNETTADSNETTTTSGPPDPGASQPLLAWLL-LPLLLLLLVLLLAAYFFRFRKQRKAVVS 80

Query: 178 SNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFN 237
           ++  ++ NG  E+ E Q V LL+RSPS  +KY P+PV+ LEEEI  R ADD K FREEFN
Sbjct: 81  TSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFN 140

Query: 238 ALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQE 297
           +LP+  IQ T E A+KEEN+EKNRY NILP DHSRV L+ ++G+P SDYINAS+I+GY+E
Sbjct: 141 SLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKE 200

Query: 298 KNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIR 357
           KNKFIAAQGPK+ETVNDFWRM+WEQ +ATIVM+TNLKERKE KC QYWPDQGCWTYGNIR
Sbjct: 201 KNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIR 260

Query: 358 VSVEDVTVLVDYTVRKFCIQ-QVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLK 416
           V VED  VLVDYT+RKFCIQ Q+ D    K  RL++Q HFTSWPDFGVPFTPIGMLKFLK
Sbjct: 261 VCVEDCVVLVDYTIRKFCIQPQLPD--GCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLK 318

Query: 417 KVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMV 476
           KVK  NP +AG IVVHCSAGVGRTGTF+VIDAM+ MMH E+KVDV+ FVSRIR QR QMV
Sbjct: 319 KVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMV 378

Query: 477 QTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKI 536
           QTDMQY FIYQALLE+YLYGDTEL+V+SLE HLQ ++         GLEEEF+KLT+++I
Sbjct: 379 QTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRI 438

Query: 537 QNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIA 596
             + MRTGNLPANMKK RV+QIIPY+FNRVI+ +KRG+E TDY+NASFIDGYRQKD +IA
Sbjct: 439 MKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIA 498

Query: 597 SQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKE 656
           +QGPL HT+EDFWRMIWEWKS +IVMLTE++ER Q+KC QYWP++G V++G+IT+E+K +
Sbjct: 499 TQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKND 558

Query: 657 EECESYTVRDLLVT-----NTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQ 711
              E+ ++RD LVT       +E + R +RQFHFHGWPE+GIP++GKGMI +IAAVQKQQ
Sbjct: 559 TLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQ 618

Query: 712 QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771
           QQ+GNHPITVHCSAGAGRTGTF ALS +LERVKAEG+LDVFQ VKSLRLQRPHMVQTLEQ
Sbjct: 619 QQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQ 678

Query: 772 YEFCYKVVQEYIDAFSDYANFK 793
           YEFCYKVVQ++ID FSDYANFK
Sbjct: 679 YEFCYKVVQDFIDIFSDYANFK 700


>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform
           2 [Homo sapiens]
          Length = 642

 Score =  924 bits (2387), Expect = 0.0
 Identities = 449/632 (71%), Positives = 531/632 (84%), Gaps = 8/632 (1%)

Query: 168 FKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMAD 227
           F+K ++A   ++  ++ NG  E+ E Q V LL+RSPS  +KY P+PV+ LEEEI  R AD
Sbjct: 13  FRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSAD 72

Query: 228 DNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYI 287
           D K FREEFN+LP+  IQ T E A+KEEN+EKNRY NILP DHSRV L+ ++G+P SDYI
Sbjct: 73  DCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYI 132

Query: 288 NASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD 347
           NAS+I+GY+EKNKFIAAQGPK+ETVNDFWRM+WEQ +ATIVM+TNLKERKE KC QYWPD
Sbjct: 133 NASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPD 192

Query: 348 QGCWTYGNIRVSVEDVTVLVDYTVRKFCIQ-QVGDMTNRKPQRLITQFHFTSWPDFGVPF 406
           QGCWTYGNIRV VED  VLVDYT+RKFCIQ Q+ D    K  RL++Q HFTSWPDFGVPF
Sbjct: 193 QGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPD--GCKAPRLVSQLHFTSWPDFGVPF 250

Query: 407 TPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVS 466
           TPIGMLKFLKKVK  NP +AG IVVHCSAGVGRTGTF+VIDAM+ MMH E+KVDV+ FVS
Sbjct: 251 TPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVS 310

Query: 467 RIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEE 526
           RIR QR QMVQTDMQY FIYQALLE+YLYGDTEL+V+SLE HLQ ++         GLEE
Sbjct: 311 RIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEE 370

Query: 527 EFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFID 586
           EF+KLT+++I  + MRTGNLPANMKK RV+QIIPY+FNRVI+ +KRG+E TDY+NASFID
Sbjct: 371 EFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFID 430

Query: 587 GYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSY 646
           GYRQKD +IA+QGPL HT+EDFWRMIWEWKS +IVMLTE++ER Q+KC QYWP++G V++
Sbjct: 431 GYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTH 490

Query: 647 GDITVELKKEEECESYTVRDLLVT-----NTRENKSRQIRQFHFHGWPEVGIPSDGKGMI 701
           G+IT+E+K +   E+ ++RD LVT       +E + R +RQFHFHGWPE+GIP++GKGMI
Sbjct: 491 GEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMI 550

Query: 702 SIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQ 761
            +IAAVQKQQQQ+GNHPITVHCSAGAGRTGTF ALS +LERVKAEG+LDVFQ VKSLRLQ
Sbjct: 551 DLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQ 610

Query: 762 RPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK 793
           RPHMVQTLEQYEFCYKVVQ++ID FSDYANFK
Sbjct: 611 RPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK 642


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score =  609 bits (1570), Expect = e-174
 Identities = 314/644 (48%), Positives = 421/644 (65%), Gaps = 12/644 (1%)

Query: 153  LLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDV-----EPQSVPLLARSPSTNR 207
            L VI+ I+IV+ +L FK+ K+  S S+    S G  + +     +P  +  L       R
Sbjct: 1269 LAVILIILIVIAILLFKR-KRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1327

Query: 208  KYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILP 267
             +PP+P+  L + I R  A+D   F +E+ ++     Q T E ++ E NK KNRY N++ 
Sbjct: 1328 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIA 1386

Query: 268  YDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATI 327
            YDHSRV LT ++GVP SDYINA++I+GY+++N +IA QGP  ET+ DFWRM+WEQ TAT+
Sbjct: 1387 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1446

Query: 328  VMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKP 387
            VM+T L+E+   KC QYWP +G  T G I+V++ D   L  YTVR F + + G    R+ 
Sbjct: 1447 VMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRE- 1505

Query: 388  QRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVID 447
               + QF F +WPD GVP  P  +L FL++VKACNP  AG +VVHCSAGVGRTG F+VID
Sbjct: 1506 ---LRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVID 1562

Query: 448  AMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLET 507
            AML+ M  E+ VD+YG V+ +R+QR  MVQT+ QYVFI++ALLE    G TE+   +L  
Sbjct: 1563 AMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYA 1622

Query: 508  HLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVI 567
            H+QK+    PG S   +E EFK L S K    +  + NLP N  KNR++ I+PYE  RV 
Sbjct: 1623 HIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVC 1682

Query: 568  IPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELE 627
            +   RG E +DY+NASF+DGYRQ+ +YIA+QGPL  + EDFWRM+WE  S  IVMLT+L 
Sbjct: 1683 LQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLR 1742

Query: 628  ERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHG 687
            E G+EKC QYWP++    Y    V+   E     Y +R+  VT+ R+ +SR IRQF F  
Sbjct: 1743 EMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTD 1802

Query: 688  WPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAE 746
            WPE G+P  G+G I  I  V K ++Q G + PITVHCSAG GRTG F  LS VLER++ E
Sbjct: 1803 WPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYE 1862

Query: 747  GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA 790
            G++D+FQTVK+LR QRP MVQT +QY+ CY+   EY+ +F  YA
Sbjct: 1863 GVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA 1906


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score =  609 bits (1570), Expect = e-174
 Identities = 314/644 (48%), Positives = 421/644 (65%), Gaps = 12/644 (1%)

Query: 153  LLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDV-----EPQSVPLLARSPSTNR 207
            L VI+ I+IV+ +L FK+ K+  S S+    S G  + +     +P  +  L       R
Sbjct: 1260 LAVILIILIVIAILLFKR-KRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1318

Query: 208  KYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILP 267
             +PP+P+  L + I R  A+D   F +E+ ++     Q T E ++ E NK KNRY N++ 
Sbjct: 1319 DHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIA 1377

Query: 268  YDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATI 327
            YDHSRV LT ++GVP SDYINA++I+GY+++N +IA QGP  ET+ DFWRM+WEQ TAT+
Sbjct: 1378 YDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATV 1437

Query: 328  VMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKP 387
            VM+T L+E+   KC QYWP +G  T G I+V++ D   L  YTVR F + + G    R+ 
Sbjct: 1438 VMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRE- 1496

Query: 388  QRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVID 447
               + QF F +WPD GVP  P  +L FL++VKACNP  AG +VVHCSAGVGRTG F+VID
Sbjct: 1497 ---LRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVID 1553

Query: 448  AMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLET 507
            AML+ M  E+ VD+YG V+ +R+QR  MVQT+ QYVFI++ALLE    G TE+   +L  
Sbjct: 1554 AMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYA 1613

Query: 508  HLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVI 567
            H+QK+    PG S   +E EFK L S K    +  + NLP N  KNR++ I+PYE  RV 
Sbjct: 1614 HIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVC 1673

Query: 568  IPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELE 627
            +   RG E +DY+NASF+DGYRQ+ +YIA+QGPL  + EDFWRM+WE  S  IVMLT+L 
Sbjct: 1674 LQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLR 1733

Query: 628  ERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHG 687
            E G+EKC QYWP++    Y    V+   E     Y +R+  VT+ R+ +SR IRQF F  
Sbjct: 1734 EMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTD 1793

Query: 688  WPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAE 746
            WPE G+P  G+G I  I  V K ++Q G + PITVHCSAG GRTG F  LS VLER++ E
Sbjct: 1794 WPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYE 1853

Query: 747  GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA 790
            G++D+FQTVK+LR QRP MVQT +QY+ CY+   EY+ +F  YA
Sbjct: 1854 GVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA 1897


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score =  601 bits (1550), Expect = e-172
 Identities = 311/679 (45%), Positives = 428/679 (63%), Gaps = 18/679 (2%)

Query: 125  SSTAATTPETFP----PSDETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGS 176
            S   AT+P + P      D  PI      ++  +  +L +VFII ++  +   K K+A S
Sbjct: 1238 SKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAES 1297

Query: 177  HSNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLF 232
             S    + N +        +P  +  L         +PP+P+ +L + I R  A+DN  F
Sbjct: 1298 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 1357

Query: 233  REEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFI 292
             +E+ ++     Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA++I
Sbjct: 1358 SQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYI 1416

Query: 293  NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWT 352
            +GY+++N +IA QG   ET  DFWRMIWEQ +AT+VM+T L+ER   KC QYWP +G  T
Sbjct: 1417 DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTET 1476

Query: 353  YGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGML 412
            +G ++V++ D   L  Y VR F + + G    R+    + QF FT+WPD GVP  P   L
Sbjct: 1477 HGLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFL 1532

Query: 413  KFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQR 472
             FL++VK CNP  AG +VVHCSAGVGRTG F+VIDAML+ +  E+ VD+YG V+ +RAQR
Sbjct: 1533 AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQR 1592

Query: 473  CQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLT 532
              MVQT+ QY+FI+ ALLE    G+TE+   +L  ++QK+     G +  G+E EFK+L 
Sbjct: 1593 NYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLA 1652

Query: 533  SIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKD 592
            S K    +  + NLP N  KNR++ I+PYE  RV +   RG E +DY+NASFIDGYRQ+ 
Sbjct: 1653 SSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQK 1712

Query: 593  SYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVE 652
            +YIA+QGPL  T EDFWRM+WE  S  +VMLT+L E G+EKC QYWP++    Y    V+
Sbjct: 1713 AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVD 1772

Query: 653  LKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ 712
               E     Y +R+  VT+ R+ +SR +RQF F  WPE G+P  G+G I  I  V K ++
Sbjct: 1773 PMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKE 1832

Query: 713  QSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771
            Q G + PI+VHCSAG GRTG F  LS VLER++ EG++D+FQTVK LR QRP MVQT +Q
Sbjct: 1833 QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQ 1892

Query: 772  YEFCYKVVQEYIDAFSDYA 790
            Y+F Y+   EY+ +F  YA
Sbjct: 1893 YQFSYRAALEYLGSFDHYA 1911


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score =  601 bits (1550), Expect = e-172
 Identities = 311/679 (45%), Positives = 428/679 (63%), Gaps = 18/679 (2%)

Query: 125  SSTAATTPETFP----PSDETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGS 176
            S   AT+P + P      D  PI      ++  +  +L +VFII ++  +   K K+A S
Sbjct: 1225 SKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAES 1284

Query: 177  HSNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLF 232
             S    + N +        +P  +  L         +PP+P+ +L + I R  A+DN  F
Sbjct: 1285 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 1344

Query: 233  REEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFI 292
             +E+ ++     Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA++I
Sbjct: 1345 SQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYI 1403

Query: 293  NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWT 352
            +GY+++N +IA QG   ET  DFWRMIWEQ +AT+VM+T L+ER   KC QYWP +G  T
Sbjct: 1404 DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTET 1463

Query: 353  YGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGML 412
            +G ++V++ D   L  Y VR F + + G    R+    + QF FT+WPD GVP  P   L
Sbjct: 1464 HGLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFL 1519

Query: 413  KFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQR 472
             FL++VK CNP  AG +VVHCSAGVGRTG F+VIDAML+ +  E+ VD+YG V+ +RAQR
Sbjct: 1520 AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQR 1579

Query: 473  CQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLT 532
              MVQT+ QY+FI+ ALLE    G+TE+   +L  ++QK+     G +  G+E EFK+L 
Sbjct: 1580 NYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLA 1639

Query: 533  SIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKD 592
            S K    +  + NLP N  KNR++ I+PYE  RV +   RG E +DY+NASFIDGYRQ+ 
Sbjct: 1640 SSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQK 1699

Query: 593  SYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVE 652
            +YIA+QGPL  T EDFWRM+WE  S  +VMLT+L E G+EKC QYWP++    Y    V+
Sbjct: 1700 AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVD 1759

Query: 653  LKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ 712
               E     Y +R+  VT+ R+ +SR +RQF F  WPE G+P  G+G I  I  V K ++
Sbjct: 1760 PMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKE 1819

Query: 713  QSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771
            Q G + PI+VHCSAG GRTG F  LS VLER++ EG++D+FQTVK LR QRP MVQT +Q
Sbjct: 1820 QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQ 1879

Query: 772  YEFCYKVVQEYIDAFSDYA 790
            Y+F Y+   EY+ +F  YA
Sbjct: 1880 YQFSYRAALEYLGSFDHYA 1898


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score =  601 bits (1550), Expect = e-172
 Identities = 311/679 (45%), Positives = 428/679 (63%), Gaps = 18/679 (2%)

Query: 125  SSTAATTPETFP----PSDETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGS 176
            S   AT+P + P      D  PI      ++  +  +L +VFII ++  +   K K+A S
Sbjct: 1229 SKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAES 1288

Query: 177  HSNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLF 232
             S    + N +        +P  +  L         +PP+P+ +L + I R  A+DN  F
Sbjct: 1289 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 1348

Query: 233  REEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFI 292
             +E+ ++     Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA++I
Sbjct: 1349 SQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYI 1407

Query: 293  NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWT 352
            +GY+++N +IA QG   ET  DFWRMIWEQ +AT+VM+T L+ER   KC QYWP +G  T
Sbjct: 1408 DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTET 1467

Query: 353  YGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGML 412
            +G ++V++ D   L  Y VR F + + G    R+    + QF FT+WPD GVP  P   L
Sbjct: 1468 HGLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFL 1523

Query: 413  KFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQR 472
             FL++VK CNP  AG +VVHCSAGVGRTG F+VIDAML+ +  E+ VD+YG V+ +RAQR
Sbjct: 1524 AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQR 1583

Query: 473  CQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLT 532
              MVQT+ QY+FI+ ALLE    G+TE+   +L  ++QK+     G +  G+E EFK+L 
Sbjct: 1584 NYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLA 1643

Query: 533  SIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKD 592
            S K    +  + NLP N  KNR++ I+PYE  RV +   RG E +DY+NASFIDGYRQ+ 
Sbjct: 1644 SSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQK 1703

Query: 593  SYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVE 652
            +YIA+QGPL  T EDFWRM+WE  S  +VMLT+L E G+EKC QYWP++    Y    V+
Sbjct: 1704 AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVD 1763

Query: 653  LKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ 712
               E     Y +R+  VT+ R+ +SR +RQF F  WPE G+P  G+G I  I  V K ++
Sbjct: 1764 PMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKE 1823

Query: 713  QSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771
            Q G + PI+VHCSAG GRTG F  LS VLER++ EG++D+FQTVK LR QRP MVQT +Q
Sbjct: 1824 QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQ 1883

Query: 772  YEFCYKVVQEYIDAFSDYA 790
            Y+F Y+   EY+ +F  YA
Sbjct: 1884 YQFSYRAALEYLGSFDHYA 1902


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
            precursor [Homo sapiens]
          Length = 1501

 Score =  601 bits (1550), Expect = e-172
 Identities = 311/679 (45%), Positives = 428/679 (63%), Gaps = 18/679 (2%)

Query: 125  SSTAATTPETFP----PSDETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGS 176
            S   AT+P + P      D  PI      ++  +  +L +VFII ++  +   K K+A S
Sbjct: 827  SKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAES 886

Query: 177  HSNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLF 232
             S    + N +        +P  +  L         +PP+P+ +L + I R  A+DN  F
Sbjct: 887  DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 946

Query: 233  REEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFI 292
             +E+ ++     Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA++I
Sbjct: 947  SQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYI 1005

Query: 293  NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWT 352
            +GY+++N +IA QG   ET  DFWRMIWEQ +AT+VM+T L+ER   KC QYWP +G  T
Sbjct: 1006 DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTET 1065

Query: 353  YGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGML 412
            +G ++V++ D   L  Y VR F + + G    R+    + QF FT+WPD GVP  P   L
Sbjct: 1066 HGLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFL 1121

Query: 413  KFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQR 472
             FL++VK CNP  AG +VVHCSAGVGRTG F+VIDAML+ +  E+ VD+YG V+ +RAQR
Sbjct: 1122 AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQR 1181

Query: 473  CQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLT 532
              MVQT+ QY+FI+ ALLE    G+TE+   +L  ++QK+     G +  G+E EFK+L 
Sbjct: 1182 NYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLA 1241

Query: 533  SIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKD 592
            S K    +  + NLP N  KNR++ I+PYE  RV +   RG E +DY+NASFIDGYRQ+ 
Sbjct: 1242 SSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQK 1301

Query: 593  SYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVE 652
            +YIA+QGPL  T EDFWRM+WE  S  +VMLT+L E G+EKC QYWP++    Y    V+
Sbjct: 1302 AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVD 1361

Query: 653  LKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ 712
               E     Y +R+  VT+ R+ +SR +RQF F  WPE G+P  G+G I  I  V K ++
Sbjct: 1362 PMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKE 1421

Query: 713  QSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771
            Q G + PI+VHCSAG GRTG F  LS VLER++ EG++D+FQTVK LR QRP MVQT +Q
Sbjct: 1422 QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQ 1481

Query: 772  YEFCYKVVQEYIDAFSDYA 790
            Y+F Y+   EY+ +F  YA
Sbjct: 1482 YQFSYRAALEYLGSFDHYA 1500


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
            precursor [Homo sapiens]
          Length = 1502

 Score =  598 bits (1543), Expect = e-171
 Identities = 307/678 (45%), Positives = 423/678 (62%), Gaps = 10/678 (1%)

Query: 118  TEPWEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSH 177
            T P+     +    P+     +E  I  V   L+ + +I  +I +L        K+A S 
Sbjct: 829  TSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESD 888

Query: 178  SNSFRLSNGRT----EDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFR 233
            S    + N +        +P  +  L         +PP+P+ +L + I R  A+DN  F 
Sbjct: 889  SRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFS 948

Query: 234  EEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFIN 293
            +E+ ++     Q T E ++ E NK KNRY N++ YDHSRV L+ +EG+P SDY+NA++I+
Sbjct: 949  QEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID 1007

Query: 294  GYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTY 353
            GY+++N +IA QG   ET  DFWRMIWEQ +AT+VM+T L+ER   KC QYWP +G  T+
Sbjct: 1008 GYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH 1067

Query: 354  GNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLK 413
            G ++V++ D   L  Y VR F + + G    R+    + QF FT+WPD GVP  P   L 
Sbjct: 1068 GLVQVTLLDTVELATYCVRTFALYKNGSSEKRE----VRQFQFTAWPDHGVPEHPTPFLA 1123

Query: 414  FLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRC 473
            FL++VK CNP  AG +VVHCSAGVGRTG F+VIDAML+ +  E+ VD+YG V+ +RAQR 
Sbjct: 1124 FLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRN 1183

Query: 474  QMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTS 533
             MVQT+ QY+FI+ ALLE    G+TE+   +L  ++QK+     G +  G+E EFK+L S
Sbjct: 1184 YMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS 1243

Query: 534  IKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDS 593
             K    +  + NLP N  KNR++ I+PYE  RV +   RG E +DY+NASFIDGYRQ+ +
Sbjct: 1244 SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKA 1303

Query: 594  YIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVEL 653
            YIA+QGPL  T EDFWRM+WE  S  +VMLT+L E G+EKC QYWP++    Y    V+ 
Sbjct: 1304 YIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDP 1363

Query: 654  KKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQ 713
              E     Y +R+  VT+ R+ +SR +RQF F  WPE G+P  G+G I  I  V K ++Q
Sbjct: 1364 MAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQ 1423

Query: 714  SG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQY 772
             G + PI+VHCSAG GRTG F  LS VLER++ EG++D+FQTVK LR QRP MVQT +QY
Sbjct: 1424 FGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQY 1483

Query: 773  EFCYKVVQEYIDAFSDYA 790
            +F Y+   EY+ +F  YA
Sbjct: 1484 QFSYRAALEYLGSFDHYA 1501


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score =  589 bits (1518), Expect = e-168
 Identities = 306/666 (45%), Positives = 420/666 (63%), Gaps = 20/666 (3%)

Query: 139  DETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNS-----FRLSNGRTE 189
            D  PI+     ++  +  +L +VFII ++  +   K K      +S       L+N    
Sbjct: 845  DPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLA 904

Query: 190  DVEPQSVPLLAR----SPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQ 245
               P+    + R    +P     +PP+P+  + E   R  A+D+    +E+ ++     Q
Sbjct: 905  PHHPKDPVEMRRINFQTPGM-LSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-Q 962

Query: 246  ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQ 305
             T E ++ E NK KNRY N++ YDHSRV L P+EG+  SDYINA++++GY+ +N +IA Q
Sbjct: 963  FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQ 1022

Query: 306  GPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTV 365
            GP  ET  DFWRM+WEQ +ATIVM+T L+E+   KC QYWP++G  TYG I+V++ D   
Sbjct: 1023 GPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIE 1082

Query: 366  LVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQY 425
            L  + VR F + + G    R+    + QF FT+WPD GVP  P   L FL++VK CNP  
Sbjct: 1083 LATFCVRTFSLHKNGSSEKRE----VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1138

Query: 426  AGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFI 485
            AG IVVHCSAGVGRTG F+VIDAML+ +  E+ VDVYG V+ +R+QR  MVQT+ QY FI
Sbjct: 1139 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1198

Query: 486  YQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGN 545
            ++ALLE    G+TE+   SL  ++QK+    PG    G+E EFK+L + K    +  + N
Sbjct: 1199 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISAN 1258

Query: 546  LPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTI 605
            LP N  KNR++ I+PYE  RV +   RG E +DY+NASFIDGYRQ+ +YIA+QGPL  T 
Sbjct: 1259 LPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1318

Query: 606  EDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVR 665
            EDFWRM+WE  S  +VMLT+L E G+EKC QYWP++    Y    V+   E     Y +R
Sbjct: 1319 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1378

Query: 666  DLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCS 724
            +  VT+ R+ +SR +RQF F  WPE G+P  G+G I  I  V K ++Q G + PI+VHCS
Sbjct: 1379 EFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCS 1438

Query: 725  AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
            AG GRTG F  LS VLER++ EG++D+FQTVK LR QRP MVQT ++Y+FCY+   EY+ 
Sbjct: 1439 AGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG 1498

Query: 785  AFSDYA 790
            +F  YA
Sbjct: 1499 SFDHYA 1504


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score =  589 bits (1518), Expect = e-168
 Identities = 306/666 (45%), Positives = 420/666 (63%), Gaps = 20/666 (3%)

Query: 139  DETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNS-----FRLSNGRTE 189
            D  PI+     ++  +  +L +VFII ++  +   K K      +S       L+N    
Sbjct: 1250 DPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLA 1309

Query: 190  DVEPQSVPLLAR----SPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQ 245
               P+    + R    +P     +PP+P+  + E   R  A+D+    +E+ ++     Q
Sbjct: 1310 PHHPKDPVEMRRINFQTPGM-LSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-Q 1367

Query: 246  ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQ 305
             T E ++ E NK KNRY N++ YDHSRV L P+EG+  SDYINA++++GY+ +N +IA Q
Sbjct: 1368 FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQ 1427

Query: 306  GPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTV 365
            GP  ET  DFWRM+WEQ +ATIVM+T L+E+   KC QYWP++G  TYG I+V++ D   
Sbjct: 1428 GPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIE 1487

Query: 366  LVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQY 425
            L  + VR F + + G    R+    + QF FT+WPD GVP  P   L FL++VK CNP  
Sbjct: 1488 LATFCVRTFSLHKNGSSEKRE----VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1543

Query: 426  AGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFI 485
            AG IVVHCSAGVGRTG F+VIDAML+ +  E+ VDVYG V+ +R+QR  MVQT+ QY FI
Sbjct: 1544 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1603

Query: 486  YQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGN 545
            ++ALLE    G+TE+   SL  ++QK+    PG    G+E EFK+L + K    +  + N
Sbjct: 1604 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISAN 1663

Query: 546  LPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTI 605
            LP N  KNR++ I+PYE  RV +   RG E +DY+NASFIDGYRQ+ +YIA+QGPL  T 
Sbjct: 1664 LPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1723

Query: 606  EDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVR 665
            EDFWRM+WE  S  +VMLT+L E G+EKC QYWP++    Y    V+   E     Y +R
Sbjct: 1724 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1783

Query: 666  DLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCS 724
            +  VT+ R+ +SR +RQF F  WPE G+P  G+G I  I  V K ++Q G + PI+VHCS
Sbjct: 1784 EFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCS 1843

Query: 725  AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
            AG GRTG F  LS VLER++ EG++D+FQTVK LR QRP MVQT ++Y+FCY+   EY+ 
Sbjct: 1844 AGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG 1903

Query: 785  AFSDYA 790
            +F  YA
Sbjct: 1904 SFDHYA 1909


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
            isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score =  589 bits (1518), Expect = e-168
 Identities = 306/666 (45%), Positives = 420/666 (63%), Gaps = 20/666 (3%)

Query: 139  DETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNS-----FRLSNGRTE 189
            D  PI+     ++  +  +L +VFII ++  +   K K      +S       L+N    
Sbjct: 841  DPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLA 900

Query: 190  DVEPQSVPLLAR----SPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQ 245
               P+    + R    +P     +PP+P+  + E   R  A+D+    +E+ ++     Q
Sbjct: 901  PHHPKDPVEMRRINFQTPGM-LSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-Q 958

Query: 246  ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQ 305
             T E ++ E NK KNRY N++ YDHSRV L P+EG+  SDYINA++++GY+ +N +IA Q
Sbjct: 959  FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQ 1018

Query: 306  GPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTV 365
            GP  ET  DFWRM+WEQ +ATIVM+T L+E+   KC QYWP++G  TYG I+V++ D   
Sbjct: 1019 GPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIE 1078

Query: 366  LVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQY 425
            L  + VR F + + G    R+    + QF FT+WPD GVP  P   L FL++VK CNP  
Sbjct: 1079 LATFCVRTFSLHKNGSSEKRE----VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1134

Query: 426  AGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFI 485
            AG IVVHCSAGVGRTG F+VIDAML+ +  E+ VDVYG V+ +R+QR  MVQT+ QY FI
Sbjct: 1135 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1194

Query: 486  YQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGN 545
            ++ALLE    G+TE+   SL  ++QK+    PG    G+E EFK+L + K    +  + N
Sbjct: 1195 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISAN 1254

Query: 546  LPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTI 605
            LP N  KNR++ I+PYE  RV +   RG E +DY+NASFIDGYRQ+ +YIA+QGPL  T 
Sbjct: 1255 LPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1314

Query: 606  EDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVR 665
            EDFWRM+WE  S  +VMLT+L E G+EKC QYWP++    Y    V+   E     Y +R
Sbjct: 1315 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1374

Query: 666  DLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCS 724
            +  VT+ R+ +SR +RQF F  WPE G+P  G+G I  I  V K ++Q G + PI+VHCS
Sbjct: 1375 EFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCS 1434

Query: 725  AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
            AG GRTG F  LS VLER++ EG++D+FQTVK LR QRP MVQT ++Y+FCY+   EY+ 
Sbjct: 1435 AGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG 1494

Query: 785  AFSDYA 790
            +F  YA
Sbjct: 1495 SFDHYA 1500


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score =  587 bits (1512), Expect = e-167
 Identities = 290/583 (49%), Positives = 390/583 (66%), Gaps = 6/583 (1%)

Query: 209  YPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPY 268
            +PP+P+  + E   R  A+D+    +E+ ++     Q T E ++ E NK KNRY N++ Y
Sbjct: 1370 HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAY 1428

Query: 269  DHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIV 328
            DHSRV L P+EG+  SDYINA++++GY+ +N +IA QGP  ET  DFWRM+WEQ +ATIV
Sbjct: 1429 DHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIV 1488

Query: 329  MVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQ 388
            M+T L+E+   KC QYWP++G  TYG I+V++ D   L  + VR F + + G    R+  
Sbjct: 1489 MMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKRE-- 1546

Query: 389  RLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDA 448
              + QF FT+WPD GVP  P   L FL++VK CNP  AG IVVHCSAGVGRTG F+VIDA
Sbjct: 1547 --VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDA 1604

Query: 449  MLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETH 508
            ML+ +  E+ VDVYG V+ +R+QR  MVQT+ QY FI++ALLE    G+TE+   SL  +
Sbjct: 1605 MLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAY 1664

Query: 509  LQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVII 568
            +QK+    PG    G+E EFK+L + K    +  + NLP N  KNR++ I+PYE  RV +
Sbjct: 1665 IQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCL 1724

Query: 569  PVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEE 628
               RG E +DY+NASFIDGYRQ+ +YIA+QGPL  T EDFWRM+WE  S  +VMLT+L E
Sbjct: 1725 QPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLRE 1784

Query: 629  RGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGW 688
             G+EKC QYWP++    Y    V+   E     Y +R+  VT+ R+ +SR +RQF F  W
Sbjct: 1785 MGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1844

Query: 689  PEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEG 747
            PE G+P  G+G I  I  V K ++Q G + PI+VHCSAG GRTG F  LS VLER++ EG
Sbjct: 1845 PEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEG 1904

Query: 748  ILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA 790
            ++D+FQTVK LR QRP MVQT ++Y+FCY+   EY+ +F  YA
Sbjct: 1905 VVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1947


>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
            precursor [Homo sapiens]
          Length = 1256

 Score =  471 bits (1212), Expect = e-132
 Identities = 267/668 (39%), Positives = 391/668 (58%), Gaps = 56/668 (8%)

Query: 147  MVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTN 206
            ++A  + L+IV  I +L +L    YK    H       + + E VE      L       
Sbjct: 529  LIAFLAFLIIVTSIALLVVL----YKIYDLHKKRSCNLDEQQELVERDDEKQLMN----- 579

Query: 207  RKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNIL 266
                P+  D L E   R++AD+ +LF  EF ++P    +   + A K  N+ KNRYV+IL
Sbjct: 580  --VEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDIL 637

Query: 267  PYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT 326
            PYD++RV L+ + G   S+YINAS+I+G++E  K+IAAQGP++ETV+DFWRMIWEQ    
Sbjct: 638  PYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATV 697

Query: 327  IVMVTNLKERKECKCAQYWP--DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 384
            IVMVT  +E    KCA+YWP  ++G   +G++ V +       DY ++K       ++ N
Sbjct: 698  IVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKL------NIVN 751

Query: 385  RKPQ---RLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTG 441
            +K +   R +T   FTSWPD GVP  P  +LK  ++V A +  ++G IVVHCSAGVGRTG
Sbjct: 752  KKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTG 811

Query: 442  TFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELE 501
            T++ IDAML+ +  E KVDVYG+V ++R QRC MVQ + QY+ I+QAL+E+  +G+TE+ 
Sbjct: 812  TYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVN 871

Query: 502  VTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPY 561
            ++ L  +L  +  + P +  + LE EF++L S +    +   GN   N  KNR   +IPY
Sbjct: 872  LSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ-HIGNQEENKSKNRNSNVIPY 930

Query: 562  EFNRVIIPVKR---------------------GEENTDYVNASFIDGYRQKDSYIASQGP 600
            ++NRV  P+K                       EE + Y+NASFI  Y + +  IA+QGP
Sbjct: 931  DYNRV--PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGP 988

Query: 601  LLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECE 660
            L  TI DFW+MI++ K   IVMLTEL+   QE CAQYW  +G  +YGDI V+LK  ++  
Sbjct: 989  LKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSS 1047

Query: 661  SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV-----QKQQQQSG 715
            +YT+R   + +++   SR + Q+ +  W    +P++ K +IS+I  V     QK   +  
Sbjct: 1048 TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 1107

Query: 716  NH----PITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771
             H    P+ +HC  G+ +TG FCAL  +LE  + E ++D+FQ VK+LR  RP MV T EQ
Sbjct: 1108 KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1167

Query: 772  YEFCYKVV 779
            Y+F Y V+
Sbjct: 1168 YQFLYDVI 1175



 Score =  197 bits (501), Expect = 3e-50
 Identities = 96/239 (40%), Positives = 146/239 (61%), Gaps = 4/239 (1%)

Query: 547 PANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIE 606
           P N  KNR + I+PY++NRV +    G+  ++Y+NAS+IDG+++   YIA+QGP   T++
Sbjct: 625 PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 684

Query: 607 DFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVELKKEEECESYTV 664
           DFWRMIWE K+  IVM+T  EE  + KCA+YWPS  +G  ++GD+ V++ + + C  Y +
Sbjct: 685 DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 744

Query: 665 RDLLVTNTRENKS-RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHC 723
           + L + N +E  + R++    F  WP+ G+P D   ++ +   V          PI VHC
Sbjct: 745 QKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSG-PIVVHC 803

Query: 724 SAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY 782
           SAG GRTGT+  +  +LE ++AE  +DV+  V  LR QR  MVQ   QY   ++ + EY
Sbjct: 804 SAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY 862



 Score =  160 bits (404), Expect = 6e-39
 Identities = 100/288 (34%), Positives = 146/288 (50%), Gaps = 34/288 (11%)

Query: 235  EFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLT-----PVEGVPDSD---- 285
            EF  LP+     T    ++EENK KNR  N++PYD++RV L        E   DSD    
Sbjct: 897  EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 956

Query: 286  ----------YINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKE 335
                      YINASFI  Y +    IAAQGP +ET+ DFW+MI+++    IVM+T LK 
Sbjct: 957  DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 1016

Query: 336  RKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFH 395
              +  CAQYW  +G  TYG+I V ++D      YT+R F ++     + RK  R + Q+ 
Sbjct: 1017 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRH----SKRKDSRTVYQYQ 1071

Query: 396  FTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGA----------IVVHCSAGVGRTGTFVV 445
            +T+W    +P  P  ++  ++ VK   PQ   +          +++HC  G  +TG F  
Sbjct: 1072 YTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCA 1131

Query: 446  IDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY 493
            +  +L+   TE  VD++  V  +R  R  MV T  QY F+Y  +   Y
Sbjct: 1132 LLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1179


>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
            precursor [Homo sapiens]
          Length = 1304

 Score =  471 bits (1212), Expect = e-132
 Identities = 267/668 (39%), Positives = 391/668 (58%), Gaps = 56/668 (8%)

Query: 147  MVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTN 206
            ++A  + L+IV  I +L +L    YK    H       + + E VE      L       
Sbjct: 577  LIAFLAFLIIVTSIALLVVL----YKIYDLHKKRSCNLDEQQELVERDDEKQLMN----- 627

Query: 207  RKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNIL 266
                P+  D L E   R++AD+ +LF  EF ++P    +   + A K  N+ KNRYV+IL
Sbjct: 628  --VEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDIL 685

Query: 267  PYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT 326
            PYD++RV L+ + G   S+YINAS+I+G++E  K+IAAQGP++ETV+DFWRMIWEQ    
Sbjct: 686  PYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATV 745

Query: 327  IVMVTNLKERKECKCAQYWP--DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 384
            IVMVT  +E    KCA+YWP  ++G   +G++ V +       DY ++K       ++ N
Sbjct: 746  IVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKL------NIVN 799

Query: 385  RKPQ---RLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTG 441
            +K +   R +T   FTSWPD GVP  P  +LK  ++V A +  ++G IVVHCSAGVGRTG
Sbjct: 800  KKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTG 859

Query: 442  TFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELE 501
            T++ IDAML+ +  E KVDVYG+V ++R QRC MVQ + QY+ I+QAL+E+  +G+TE+ 
Sbjct: 860  TYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVN 919

Query: 502  VTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPY 561
            ++ L  +L  +  + P +  + LE EF++L S +    +   GN   N  KNR   +IPY
Sbjct: 920  LSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ-HIGNQEENKSKNRNSNVIPY 978

Query: 562  EFNRVIIPVKR---------------------GEENTDYVNASFIDGYRQKDSYIASQGP 600
            ++NRV  P+K                       EE + Y+NASFI  Y + +  IA+QGP
Sbjct: 979  DYNRV--PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGP 1036

Query: 601  LLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECE 660
            L  TI DFW+MI++ K   IVMLTEL+   QE CAQYW  +G  +YGDI V+LK  ++  
Sbjct: 1037 LKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSS 1095

Query: 661  SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV-----QKQQQQSG 715
            +YT+R   + +++   SR + Q+ +  W    +P++ K +IS+I  V     QK   +  
Sbjct: 1096 TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 1155

Query: 716  NH----PITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771
             H    P+ +HC  G+ +TG FCAL  +LE  + E ++D+FQ VK+LR  RP MV T EQ
Sbjct: 1156 KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1215

Query: 772  YEFCYKVV 779
            Y+F Y V+
Sbjct: 1216 YQFLYDVI 1223



 Score =  197 bits (501), Expect = 3e-50
 Identities = 96/239 (40%), Positives = 146/239 (61%), Gaps = 4/239 (1%)

Query: 547 PANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIE 606
           P N  KNR + I+PY++NRV +    G+  ++Y+NAS+IDG+++   YIA+QGP   T++
Sbjct: 673 PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 732

Query: 607 DFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVELKKEEECESYTV 664
           DFWRMIWE K+  IVM+T  EE  + KCA+YWPS  +G  ++GD+ V++ + + C  Y +
Sbjct: 733 DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 792

Query: 665 RDLLVTNTRENKS-RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHC 723
           + L + N +E  + R++    F  WP+ G+P D   ++ +   V          PI VHC
Sbjct: 793 QKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSG-PIVVHC 851

Query: 724 SAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY 782
           SAG GRTGT+  +  +LE ++AE  +DV+  V  LR QR  MVQ   QY   ++ + EY
Sbjct: 852 SAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY 910



 Score =  160 bits (404), Expect = 6e-39
 Identities = 100/288 (34%), Positives = 146/288 (50%), Gaps = 34/288 (11%)

Query: 235  EFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLT-----PVEGVPDSD---- 285
            EF  LP+     T    ++EENK KNR  N++PYD++RV L        E   DSD    
Sbjct: 945  EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 1004

Query: 286  ----------YINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKE 335
                      YINASFI  Y +    IAAQGP +ET+ DFW+MI+++    IVM+T LK 
Sbjct: 1005 DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 1064

Query: 336  RKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFH 395
              +  CAQYW  +G  TYG+I V ++D      YT+R F ++     + RK  R + Q+ 
Sbjct: 1065 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRH----SKRKDSRTVYQYQ 1119

Query: 396  FTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGA----------IVVHCSAGVGRTGTFVV 445
            +T+W    +P  P  ++  ++ VK   PQ   +          +++HC  G  +TG F  
Sbjct: 1120 YTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCA 1179

Query: 446  IDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY 493
            +  +L+   TE  VD++  V  +R  R  MV T  QY F+Y  +   Y
Sbjct: 1180 LLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1227


>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
            precursor [Homo sapiens]
          Length = 1143

 Score =  471 bits (1212), Expect = e-132
 Identities = 267/668 (39%), Positives = 391/668 (58%), Gaps = 56/668 (8%)

Query: 147  MVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTN 206
            ++A  + L+IV  I +L +L    YK    H       + + E VE      L       
Sbjct: 416  LIAFLAFLIIVTSIALLVVL----YKIYDLHKKRSCNLDEQQELVERDDEKQLMN----- 466

Query: 207  RKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNIL 266
                P+  D L E   R++AD+ +LF  EF ++P    +   + A K  N+ KNRYV+IL
Sbjct: 467  --VEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDIL 524

Query: 267  PYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT 326
            PYD++RV L+ + G   S+YINAS+I+G++E  K+IAAQGP++ETV+DFWRMIWEQ    
Sbjct: 525  PYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATV 584

Query: 327  IVMVTNLKERKECKCAQYWP--DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 384
            IVMVT  +E    KCA+YWP  ++G   +G++ V +       DY ++K       ++ N
Sbjct: 585  IVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKL------NIVN 638

Query: 385  RKPQ---RLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTG 441
            +K +   R +T   FTSWPD GVP  P  +LK  ++V A +  ++G IVVHCSAGVGRTG
Sbjct: 639  KKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTG 698

Query: 442  TFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELE 501
            T++ IDAML+ +  E KVDVYG+V ++R QRC MVQ + QY+ I+QAL+E+  +G+TE+ 
Sbjct: 699  TYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVN 758

Query: 502  VTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPY 561
            ++ L  +L  +  + P +  + LE EF++L S +    +   GN   N  KNR   +IPY
Sbjct: 759  LSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ-HIGNQEENKSKNRNSNVIPY 817

Query: 562  EFNRVIIPVKR---------------------GEENTDYVNASFIDGYRQKDSYIASQGP 600
            ++NRV  P+K                       EE + Y+NASFI  Y + +  IA+QGP
Sbjct: 818  DYNRV--PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGP 875

Query: 601  LLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECE 660
            L  TI DFW+MI++ K   IVMLTEL+   QE CAQYW  +G  +YGDI V+LK  ++  
Sbjct: 876  LKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSS 934

Query: 661  SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV-----QKQQQQSG 715
            +YT+R   + +++   SR + Q+ +  W    +P++ K +IS+I  V     QK   +  
Sbjct: 935  TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 994

Query: 716  NH----PITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ 771
             H    P+ +HC  G+ +TG FCAL  +LE  + E ++D+FQ VK+LR  RP MV T EQ
Sbjct: 995  KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1054

Query: 772  YEFCYKVV 779
            Y+F Y V+
Sbjct: 1055 YQFLYDVI 1062



 Score =  197 bits (501), Expect = 3e-50
 Identities = 96/239 (40%), Positives = 146/239 (61%), Gaps = 4/239 (1%)

Query: 547 PANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIE 606
           P N  KNR + I+PY++NRV +    G+  ++Y+NAS+IDG+++   YIA+QGP   T++
Sbjct: 512 PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 571

Query: 607 DFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVELKKEEECESYTV 664
           DFWRMIWE K+  IVM+T  EE  + KCA+YWPS  +G  ++GD+ V++ + + C  Y +
Sbjct: 572 DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 631

Query: 665 RDLLVTNTRENKS-RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHC 723
           + L + N +E  + R++    F  WP+ G+P D   ++ +   V          PI VHC
Sbjct: 632 QKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSG-PIVVHC 690

Query: 724 SAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY 782
           SAG GRTGT+  +  +LE ++AE  +DV+  V  LR QR  MVQ   QY   ++ + EY
Sbjct: 691 SAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY 749



 Score =  160 bits (404), Expect = 6e-39
 Identities = 100/288 (34%), Positives = 146/288 (50%), Gaps = 34/288 (11%)

Query: 235  EFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLT-----PVEGVPDSD---- 285
            EF  LP+     T    ++EENK KNR  N++PYD++RV L        E   DSD    
Sbjct: 784  EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 843

Query: 286  ----------YINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKE 335
                      YINASFI  Y +    IAAQGP +ET+ DFW+MI+++    IVM+T LK 
Sbjct: 844  DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 903

Query: 336  RKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFH 395
              +  CAQYW  +G  TYG+I V ++D      YT+R F ++     + RK  R + Q+ 
Sbjct: 904  GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRH----SKRKDSRTVYQYQ 958

Query: 396  FTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGA----------IVVHCSAGVGRTGTFVV 445
            +T+W    +P  P  ++  ++ VK   PQ   +          +++HC  G  +TG F  
Sbjct: 959  YTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCA 1018

Query: 446  IDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY 493
            +  +L+   TE  VD++  V  +R  R  MV T  QY F+Y  +   Y
Sbjct: 1019 LLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1066


>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
            [Homo sapiens]
          Length = 1440

 Score =  441 bits (1135), Expect = e-123
 Identities = 236/588 (40%), Positives = 356/588 (60%), Gaps = 16/588 (2%)

Query: 205  TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 264
            T + +P + V  L + IN     D+  F+EE+ +       A+ + A K++N+ KNRY N
Sbjct: 861  TGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGN 919

Query: 265  ILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNT 324
            I+ YDHSRV L PVE  P SDYINA++I+GYQ  + +IA QGP  ETV DFWRMIW++ +
Sbjct: 920  IIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQS 979

Query: 325  ATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 384
            A IVMVTNL E    KC +YWPD     YG+ +V+  ++  L +Y VR F +++ G    
Sbjct: 980  ACIVMVTNLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEI 1038

Query: 385  RKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFV 444
            R+    + QFHFT WPD GVP+   G+L F+++VK  NP  AG IVVHCSAG GRTG ++
Sbjct: 1039 RE----VKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYI 1094

Query: 445  VIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTS 504
            VID MLDM   E  VD+Y  V  +R++R  MVQT+ QY+FI+ A+LE  L G+T + V  
Sbjct: 1095 VIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCE 1154

Query: 505  LETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVLQIIPYE 562
             +     +      T+++ L++EF+ L S+  ++Q +      LP N  KNR + ++P +
Sbjct: 1155 FKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPD 1214

Query: 563  FNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVM 622
                 +    G E+++Y+NA+ +D YRQ  ++I +Q PL +T++DFWR+++++   SIVM
Sbjct: 1215 RCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVM 1273

Query: 623  LTELEERGQEKCAQYWPSDGLVSYGDITVE-LKKEEECESYTVRDLLVTNTRENKS-RQI 680
            L E++    + C QYWP +G++ YG I VE +    +C+       +   TR  +    +
Sbjct: 1274 LNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMV 1331

Query: 681  RQFHFHGW-PEVGIPSDGKGMISIIAAVQKQQQ--QSGNHPITVHCSAGAGRTGTFCALS 737
            +QF + GW     +P   +  + +I  V+K Q+  + G     +HC  G GR+G FCA+ 
Sbjct: 1332 QQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIG 1391

Query: 738  TVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA 785
             V+E VK + ++DVF  VK+LR  +P+MV+  EQY FCY V  EY+++
Sbjct: 1392 IVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439


>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
            precursor [Homo sapiens]
          Length = 1452

 Score =  440 bits (1131), Expect = e-123
 Identities = 235/601 (39%), Positives = 361/601 (60%), Gaps = 21/601 (3%)

Query: 192  EPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAA 251
            EP  VP       T + +P + V  L + I +    +   F+EE+ +       A  ++A
Sbjct: 865  EPADVPY-----QTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQ-SAPWDSA 918

Query: 252  SKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEET 311
             K+EN+ KNRY NI+ YDHSRV L  +EG  +SDYIN ++I+GY   N +IA QGP +ET
Sbjct: 919  KKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQET 978

Query: 312  VNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTV 371
            + DFWRM+W +NTA+I+MVTNL E    KC +YWPD     Y +I+V++ +  +L +Y +
Sbjct: 979  IYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAEYVI 1037

Query: 372  RKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVV 431
            R F +++ G    R+    I QFHFT WPD GVP+   G+L F+++VK+ +P  AG +VV
Sbjct: 1038 RTFAVEKRGVHEIRE----IRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVV 1093

Query: 432  HCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE 491
            HCSAG GRTG F+VID MLDM   E  VD+Y  V  +R++R  MVQT+ QYVFI+ A+LE
Sbjct: 1094 HCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1153

Query: 492  HYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPAN 549
              L GDT +  + + +    +    P T+++ ++EEF+ L  +   ++ +      LP N
Sbjct: 1154 ACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRN 1213

Query: 550  MKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFW 609
             +KNR + I+P +     +    G E+++Y+NA+ +D Y+Q  ++I +Q PL +T++DFW
Sbjct: 1214 HEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFW 1272

Query: 610  RMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLV 669
            R++ ++   S+VML +++    + C QYWP +G+  +G I VE    +  E    R   +
Sbjct: 1273 RLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRI 1330

Query: 670  TNTR--ENKSRQIRQFHFHGWPEV-GIPSDGKGMISIIAAVQKQQQQ--SGNHPITVHCS 724
             N    ++  R ++QF F GWP     P   +  + +I  V K Q++   G     VHC 
Sbjct: 1331 YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCL 1390

Query: 725  AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
             G GR+GTFCA+S V E ++ +  +DVF  VK+LR  +P+MV  L+QY+FCY+V  EY++
Sbjct: 1391 NGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN 1450

Query: 785  A 785
            +
Sbjct: 1451 S 1451


>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
            precursor [Homo sapiens]
          Length = 1465

 Score =  440 bits (1131), Expect = e-123
 Identities = 235/601 (39%), Positives = 361/601 (60%), Gaps = 21/601 (3%)

Query: 192  EPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAA 251
            EP  VP       T + +P + V  L + I +    +   F+EE+ +       A  ++A
Sbjct: 878  EPADVPY-----QTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQ-SAPWDSA 931

Query: 252  SKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEET 311
             K+EN+ KNRY NI+ YDHSRV L  +EG  +SDYIN ++I+GY   N +IA QGP +ET
Sbjct: 932  KKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQET 991

Query: 312  VNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTV 371
            + DFWRM+W +NTA+I+MVTNL E    KC +YWPD     Y +I+V++ +  +L +Y +
Sbjct: 992  IYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAEYVI 1050

Query: 372  RKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVV 431
            R F +++ G    R+    I QFHFT WPD GVP+   G+L F+++VK+ +P  AG +VV
Sbjct: 1051 RTFAVEKRGVHEIRE----IRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVV 1106

Query: 432  HCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE 491
            HCSAG GRTG F+VID MLDM   E  VD+Y  V  +R++R  MVQT+ QYVFI+ A+LE
Sbjct: 1107 HCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1166

Query: 492  HYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPAN 549
              L GDT +  + + +    +    P T+++ ++EEF+ L  +   ++ +      LP N
Sbjct: 1167 ACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRN 1226

Query: 550  MKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFW 609
             +KNR + I+P +     +    G E+++Y+NA+ +D Y+Q  ++I +Q PL +T++DFW
Sbjct: 1227 HEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFW 1285

Query: 610  RMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLV 669
            R++ ++   S+VML +++    + C QYWP +G+  +G I VE    +  E    R   +
Sbjct: 1286 RLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRI 1343

Query: 670  TNTR--ENKSRQIRQFHFHGWPEV-GIPSDGKGMISIIAAVQKQQQQ--SGNHPITVHCS 724
             N    ++  R ++QF F GWP     P   +  + +I  V K Q++   G     VHC 
Sbjct: 1344 YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCL 1403

Query: 725  AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
             G GR+GTFCA+S V E ++ +  +DVF  VK+LR  +P+MV  L+QY+FCY+V  EY++
Sbjct: 1404 NGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN 1463

Query: 785  A 785
            +
Sbjct: 1464 S 1464


>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
            [Homo sapiens]
          Length = 1446

 Score =  435 bits (1118), Expect = e-122
 Identities = 236/594 (39%), Positives = 356/594 (59%), Gaps = 22/594 (3%)

Query: 205  TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 264
            T + +P + V  L + IN     D+  F+EE+ +       A+ + A K++N+ KNRY N
Sbjct: 861  TGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGN 919

Query: 265  ILPYDHSRVHLTPVEGVPDSDYINASFIN------GYQEKNKFIAAQGPKEETVNDFWRM 318
            I+ YDHSRV L PVE  P SDYINA++I+      GYQ  + +IA QGP  ETV DFWRM
Sbjct: 920  IIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRM 979

Query: 319  IWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQ 378
            IW++ +A IVMVTNL E    KC +YWPD     YG+ +V+  ++  L +Y VR F +++
Sbjct: 980  IWQEQSACIVMVTNLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLER 1038

Query: 379  VGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVG 438
             G    R+    + QFHFT WPD GVP+   G+L F+++VK  NP  AG IVVHCSAG G
Sbjct: 1039 RGYNEIRE----VKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAG 1094

Query: 439  RTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDT 498
            RTG ++VID MLDM   E  VD+Y  V  +R++R  MVQT+ QY+FI+ A+LE  L G+T
Sbjct: 1095 RTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGET 1154

Query: 499  ELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVL 556
             + V   +     +      T+++ L++EF+ L S+  ++Q +      LP N  KNR +
Sbjct: 1155 AIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFM 1214

Query: 557  QIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWK 616
             ++P +     +    G E+++Y+NA+ +D YRQ  ++I +Q PL +T++DFWR+++++ 
Sbjct: 1215 DMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYG 1273

Query: 617  SCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVE-LKKEEECESYTVRDLLVTNTREN 675
              SIVML E++    + C QYWP +G++ YG I VE +    +C+       +   TR  
Sbjct: 1274 CTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQ 1331

Query: 676  KS-RQIRQFHFHGW-PEVGIPSDGKGMISIIAAVQKQQQ--QSGNHPITVHCSAGAGRTG 731
            +    ++QF + GW     +P   +  + +I  V+K Q+  + G     +HC  G GR+G
Sbjct: 1332 EGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSG 1391

Query: 732  TFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA 785
             FCA+  V+E VK + ++DVF  VK+LR  +P+MV+  EQY FCY V  EY+++
Sbjct: 1392 MFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445


>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
            precursor [Homo sapiens]
          Length = 1441

 Score =  434 bits (1117), Expect = e-121
 Identities = 231/584 (39%), Positives = 352/584 (60%), Gaps = 16/584 (2%)

Query: 210  PPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYD 269
            P + V  L + I +        F+EE+ ALP     A+ + A ++EN+ KNRY NI+ YD
Sbjct: 867  PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYD 925

Query: 270  HSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVM 329
            HSRV L  ++G P SDYINA++I+GY     +IA QGP +ETV DFWRMIW++N+A+IVM
Sbjct: 926  HSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVM 985

Query: 330  VTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQR 389
            VTNL E    KC +YWPD     YG+I+V++ +   L +Y +R F +Q+ G    R+   
Sbjct: 986  VTNLVEVGRVKCVRYWPDD-TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRE--- 1041

Query: 390  LITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAM 449
             +  FHFTSWPD GVP    G+L F+++VK  NP  AG IVVHCSAG GRTG F+ ID M
Sbjct: 1042 -LRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTM 1100

Query: 450  LDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL 509
            LDM   E  VD++  V  +RAQR  +VQT+ QYVF++ A+LE  L G+T + V    +  
Sbjct: 1101 LDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLY 1160

Query: 510  QKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVI 567
              I    P T+++ +++EF+ L  +  +++ +    G LP N  KNR + ++P +   + 
Sbjct: 1161 YNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLD-RCLP 1219

Query: 568  IPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELE 627
              +    E+++Y+NA+ +D ++Q  +++ +Q PL +T+ DFWR+++++   S+VML E++
Sbjct: 1220 FLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMD 1279

Query: 628  ERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTR--ENKSRQIRQFHF 685
                + C QYWP      YG I VE    +  E    R   + N    ++  R ++   +
Sbjct: 1280 T--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQY 1337

Query: 686  HGWPEV-GIPSDGKGMISIIAAVQK-QQQQSGNHPIT-VHCSAGAGRTGTFCALSTVLER 742
             GWP     P   + ++ ++  ++K Q+Q  G    T VHC  G GR+GTFCA+ +V E 
Sbjct: 1338 IGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEM 1397

Query: 743  VKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF 786
            ++ + I+DVF  VK+LR  + +MV+TLEQY+F Y+V  EY+ +F
Sbjct: 1398 IQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1441


>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
            precursor [Homo sapiens]
          Length = 1460

 Score =  434 bits (1117), Expect = e-121
 Identities = 231/584 (39%), Positives = 352/584 (60%), Gaps = 16/584 (2%)

Query: 210  PPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYD 269
            P + V  L + I +        F+EE+ ALP     A+ + A ++EN+ KNRY NI+ YD
Sbjct: 886  PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYD 944

Query: 270  HSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVM 329
            HSRV L  ++G P SDYINA++I+GY     +IA QGP +ETV DFWRMIW++N+A+IVM
Sbjct: 945  HSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVM 1004

Query: 330  VTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQR 389
            VTNL E    KC +YWPD     YG+I+V++ +   L +Y +R F +Q+ G    R+   
Sbjct: 1005 VTNLVEVGRVKCVRYWPDD-TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRE--- 1060

Query: 390  LITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAM 449
             +  FHFTSWPD GVP    G+L F+++VK  NP  AG IVVHCSAG GRTG F+ ID M
Sbjct: 1061 -LRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTM 1119

Query: 450  LDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL 509
            LDM   E  VD++  V  +RAQR  +VQT+ QYVF++ A+LE  L G+T + V    +  
Sbjct: 1120 LDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLY 1179

Query: 510  QKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVI 567
              I    P T+++ +++EF+ L  +  +++ +    G LP N  KNR + ++P +   + 
Sbjct: 1180 YNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLD-RCLP 1238

Query: 568  IPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELE 627
              +    E+++Y+NA+ +D ++Q  +++ +Q PL +T+ DFWR+++++   S+VML E++
Sbjct: 1239 FLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMD 1298

Query: 628  ERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTR--ENKSRQIRQFHF 685
                + C QYWP      YG I VE    +  E    R   + N    ++  R ++   +
Sbjct: 1299 T--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQY 1356

Query: 686  HGWPEV-GIPSDGKGMISIIAAVQK-QQQQSGNHPIT-VHCSAGAGRTGTFCALSTVLER 742
             GWP     P   + ++ ++  ++K Q+Q  G    T VHC  G GR+GTFCA+ +V E 
Sbjct: 1357 IGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEM 1416

Query: 743  VKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF 786
            ++ + I+DVF  VK+LR  + +MV+TLEQY+F Y+V  EY+ +F
Sbjct: 1417 IQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1460


>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
            precursor [Homo sapiens]
          Length = 2315

 Score =  408 bits (1048), Expect = e-113
 Identities = 256/761 (33%), Positives = 399/761 (52%), Gaps = 36/761 (4%)

Query: 42   PVKEEAKT----SNPTSSLTSLSVAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSI 97
            P+  E+K     ++   S +    + + + N T         N  D+D       S  + 
Sbjct: 1532 PLSPESKAWAVLTSDEESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITP 1591

Query: 98   GITISPNGTWLPDNQFTDARTEPWEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIV 157
            G   SP  +   +N      +E    NSS  +          E   +  +V +S+L  I 
Sbjct: 1592 GFPQSPTSSVTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFIC 1651

Query: 158  FIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSV-PLLARSPSTNRKYPPLPVDK 216
             +++V  ++ ++K  Q  +H      ++ R     P  + P+     +   K+ P  V  
Sbjct: 1652 LVVLVGILIYWRKCFQT-AHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVAD 1710

Query: 217  LEEEINRRMADDNKLFREEFNALPACPIQA--TCEAASKEENKEKNRYVNILPYDHSRVH 274
            L         ++ +  +E +  + +C +    T ++++  +NK KNRY+NI+ YDHSRV 
Sbjct: 1711 LHASSG--FTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVK 1768

Query: 275  LTPVEGVPD--SDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTN 332
            L  +       +DYINA++++GY     +IAAQGP + T  DFWRMIWE N   IVM+TN
Sbjct: 1769 LAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITN 1828

Query: 333  LKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQV----GDMTNRKPQ 388
            L E+   KC QYWP  G   YGN  V+ + V VL  YTVR F ++      G    R   
Sbjct: 1829 LVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSG 1888

Query: 389  RLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDA 448
            R++TQ+H+T WPD GVP   + +L F++K         G +VVHCSAGVGRTGT++V+D+
Sbjct: 1889 RVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDS 1948

Query: 449  MLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETH 508
            ML  +  E  V+++GF+  IR+QR  +VQT+ QYVFI+  L+E  L  +TE+    L++H
Sbjct: 1949 MLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV----LDSH 2004

Query: 509  LQKIYNK--IPG-TSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNR 565
            +    N   IPG      LE++F+ L+   IQ           N +KNR   IIP E +R
Sbjct: 2005 IHAYVNALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSR 2064

Query: 566  VIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTE 625
            V I    G E TDY+NAS+I GY Q + +I +Q PLLHTI+DFWRMIW+  +  +VM+ +
Sbjct: 2065 VGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPD 2123

Query: 626  LEERGQEKCAQYWPS-DGLVSYGDITVELKKEE-EC----ESYTVRDLLVTNTRENKSRQ 679
             +   +++   YWP+ D  ++     V L  EE +C    E   ++D ++  T+++   +
Sbjct: 2124 GQNMAEDEFV-YWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLE 2182

Query: 680  IRQFHFHGWPEVGIP-SDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALST 738
            +R F    WP    P S    +IS+I    K++  + + P+ VH   G    GTFCAL+T
Sbjct: 2183 VRHFQCPKWPNPDSPISKTFELISVI----KEEAANRDGPMIVHDEHGGVTAGTFCALTT 2238

Query: 739  VLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVV 779
            ++ +++ E  +DV+Q  K + L RP +   +EQY+F YKV+
Sbjct: 2239 LMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVI 2279



 Score =  201 bits (510), Expect = 3e-51
 Identities = 105/282 (37%), Positives = 167/282 (59%), Gaps = 19/282 (6%)

Query: 520  SNNGLEEEFKKLTSI--KIQNDKMRTG------NLPANMKKNRVLQIIPYEFNRVIIP-- 569
            +++G  EEF+ L     ++Q+  +  G      N P N  KNR + I+ Y+ +RV +   
Sbjct: 1713 ASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQL 1772

Query: 570  VKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEER 629
             ++  + TDY+NA+++DGY +  +YIA+QGPL  T EDFWRMIWE     IVM+T L E+
Sbjct: 1773 AEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEK 1832

Query: 630  GQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQ--------IR 681
            G+ KC QYWP+DG   YG+  V  K  +    YTVR+  + NT+  K  Q        + 
Sbjct: 1833 GRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVT 1892

Query: 682  QFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLE 741
            Q+H+  WP++G+P     +++ +      ++ +   P+ VHCSAG GRTGT+  L ++L+
Sbjct: 1893 QYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVG-PVVVHCSAGVGRTGTYIVLDSMLQ 1951

Query: 742  RVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI 783
            +++ EG +++F  +K +R QR ++VQT EQY F +  + E I
Sbjct: 1952 QIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI 1993



 Score =  116 bits (291), Expect = 7e-26
 Identities = 82/269 (30%), Positives = 130/269 (48%), Gaps = 12/269 (4%)

Query: 245  QATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAA 304
            Q+   AA K+ N+EKNR  +I+P + SRV ++ + G   +DYINAS+I GY + N+FI  
Sbjct: 2037 QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIIT 2095

Query: 305  QGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ----GCWTYGNIRVSV 360
            Q P   T+ DFWRMIW+ N   +VM+ + +   E +   YWP++     C ++  + +  
Sbjct: 2096 QHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV-YWPNKDEPINCESF-KVTLMA 2153

Query: 361  EDVTVLVDYTVRKFCIQQ-VGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVK 419
            E+   L +    K  IQ  + + T       +  F    WP+   P +    L  + K +
Sbjct: 2154 EEHKCLSNE--EKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEE 2211

Query: 420  ACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTD 479
            A N    G ++VH   G    GTF  +  ++  +  E  VDVY     I   R  +    
Sbjct: 2212 AANRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADI 2269

Query: 480  MQYVFIYQALLEHYLYGDTELEVTSLETH 508
             QY F+Y+ +L        E   TSL+++
Sbjct: 2270 EQYQFLYKVILSLVSTRQEENPSTSLDSN 2298


>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
            [Homo sapiens]
          Length = 1445

 Score =  404 bits (1039), Expect = e-112
 Identities = 246/702 (35%), Positives = 381/702 (54%), Gaps = 54/702 (7%)

Query: 120  PWEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIVFIIIVLYML------------R 167
            P E N+S   + P         P+I V  AL+ + +I+ I +++Y              R
Sbjct: 718  PAEKNTSGMISRPAPGRMEWIIPLIVVS-ALTFVCLILLIAVLVYWRGCNKIKSKGFPRR 776

Query: 168  FKKYKQAGSHSNS-----FRLSNGRTED------VEPQSVPLLARSPSTNRKYPPLPVDK 216
            F++   +G          F+ ++   ED      V  +S+P++            +PV +
Sbjct: 777  FREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEA----IPVKQ 832

Query: 217  LEEEINRRMADDNKLFREEFNALPACP--IQATCEAASKEENKEKNRYVNILPYDHSRVH 274
              + I    +++   F E+F  +  C   +  T E ++  ENK KNRY+NIL YDHSRV 
Sbjct: 833  FVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVK 892

Query: 275  LTPVEGVPD--SDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTN 332
            L P+ G     SDYINA++++GY +   +IA QGP + T  DFWRMIWEQNT  IVM+TN
Sbjct: 893  LRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITN 952

Query: 333  LKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQ-------QVGDMTNR 385
            L E+   KC QYWP +    YGNI V+++   +   YTVR+F I+       Q G+   R
Sbjct: 953  LVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGR 1012

Query: 386  KPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVV 445
            + +R++ Q+H+T WPD GVP   + +L F+++  A      G ++VHCSAGVGRTGT++V
Sbjct: 1013 QNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIV 1072

Query: 446  IDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSL 505
            ID+ML  +  +  V+V GF+  IR QR  +VQT+ QY+FI+ ALLE  L  +TE+    L
Sbjct: 1073 IDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQL 1132

Query: 506  ETHLQKIYNKIPGT-SNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFN 564
             +++  I   IPG      LE++FK +T    +  +  +     N +KNR   ++P E  
Sbjct: 1133 HSYVNSIL--IPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERA 1190

Query: 565  RVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLT 624
            RV +    G + TDY+NAS+I GY + + +I +Q PL HT +DFWRMIW+  +  IVML 
Sbjct: 1191 RVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLP 1250

Query: 625  ELEERGQEKCAQYWPS-DGLVSYGDITVEL-KKEEEC----ESYTVRDLLVTNTRENKSR 678
            + +   +++   YWPS +  ++    TV L  K+  C    E   + D ++  T+++   
Sbjct: 1251 DNQSLAEDEFV-YWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVL 1309

Query: 679  QIRQFHFHGWPEVGIP-SDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALS 737
            ++R F    WP    P S    +I++I    K++  + + P  VH   GA   G  CAL+
Sbjct: 1310 EVRHFQCPKWPNPDAPISSTFELINVI----KEEALTRDGPTIVHDEYGAVSAGMLCALT 1365

Query: 738  TVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVV 779
            T+ ++++ E  +DVFQ  K + L RP +   +EQY+F YK +
Sbjct: 1366 TLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAM 1407



 Score =  195 bits (495), Expect = 2e-49
 Identities = 103/298 (34%), Positives = 168/298 (56%), Gaps = 19/298 (6%)

Query: 500  LEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQ-NDKMRTGNLPANMKKNRVLQI 558
            + V     H+ ++Y+     + +G  E+F+++       N      N P N  KNR + I
Sbjct: 828  IPVKQFVKHIGELYSN----NQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINI 883

Query: 559  IPYEFNRVIIPVKRGEEN--TDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWK 616
            + Y+ +RV +    G+++  +DY+NA+++DGY +  +YIA+QGPL  T EDFWRMIWE  
Sbjct: 884  LAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQN 943

Query: 617  SCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENK 676
            +  IVM+T L E+G+ KC QYWP++    YG+I V LK  +    YTVR   + NT+  K
Sbjct: 944  TGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKK 1003

Query: 677  S-----------RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSA 725
                        R + Q+H+  WP++G+P     +++ +      +      P+ VHCSA
Sbjct: 1004 GQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETG-PVLVHCSA 1062

Query: 726  GAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI 783
            G GRTGT+  + ++L+++K +  ++V   +K +R QR ++VQT EQY F +  + E I
Sbjct: 1063 GVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI 1120



 Score =  113 bits (283), Expect = 6e-25
 Identities = 77/264 (29%), Positives = 121/264 (45%), Gaps = 14/264 (5%)

Query: 234  EEFNALPACPIQ-ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFI 292
            ++F  +  C  +   C +A KE NKEKNR  +++P + +RV L P+ G+  +DYINAS+I
Sbjct: 1152 KQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYI 1211

Query: 293  NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ---- 348
             GY   N+FI  Q P   T  DFWRMIW+ N   IVM+ + +   E +   YWP +    
Sbjct: 1212 MGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFV-YWPSREESM 1270

Query: 349  GCWTYGNIRVSVEDVTVLVD--YTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPF 406
             C  +    +S + + +  +    +  F ++   D    +    +  F    WP+   P 
Sbjct: 1271 NCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLE----VRHFQCPKWPNPDAPI 1326

Query: 407  TPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVS 466
            +    L  + K +A      G  +VH   G    G    +  +   +  E  VDV+    
Sbjct: 1327 SSTFELINVIKEEALTRD--GPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAK 1384

Query: 467  RIRAQRCQMVQTDMQYVFIYQALL 490
             I   R  +     QY FIY+A+L
Sbjct: 1385 MINLMRPGVFTDIEQYQFIYKAML 1408


>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
            precursor [Homo sapiens]
          Length = 1436

 Score =  404 bits (1039), Expect = e-112
 Identities = 214/586 (36%), Positives = 334/586 (56%), Gaps = 17/586 (2%)

Query: 205  TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 264
            T + +P + V  L + IN+    +   F++E+ +          +A  K++  + +R   
Sbjct: 857  TGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESF-----FEGWDATKKKDKVKGSRQEP 911

Query: 265  ILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNT 324
            +  YD  RV L P+ G P++DYINA++I+GY   N FIA QGPK E V DFWRM+W+++ 
Sbjct: 912  MPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHC 971

Query: 325  ATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 384
            ++IVM+T L E    KC++YWP+    TYG+I++ +     L +Y VR F +++ G    
Sbjct: 972  SSIVMITKLVEVGRVKCSRYWPEDSD-TYGDIKIMLVKTETLAEYVVRTFALERRGYSAR 1030

Query: 385  RKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFV 444
             +    + QFHFT+WP+ GVP+   G+L F+++VKA  P  AG IV+HCSAG GRTG ++
Sbjct: 1031 HE----VRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYI 1086

Query: 445  VIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTS 504
            V+D MLDM   E  VD+Y  V  + ++R  M+QT+ QY+FI+ A+LE  L G+T + V+ 
Sbjct: 1087 VLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSE 1146

Query: 505  LETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVLQIIPYE 562
             +   +++    P ++++ L EEF+ L S+   +  ++     LP N  KNR + ++P +
Sbjct: 1147 FKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD 1206

Query: 563  FNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVM 622
                 +    G+ N +Y+NA+  D Y +  ++I +  PL  T  DFWR+++++   SIVM
Sbjct: 1207 RCLPFLISTDGDSN-NYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVM 1265

Query: 623  LTELEERGQE-KCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQ-- 679
            L +L +      C QYWP  G   YG + VE       E    R   V N    +     
Sbjct: 1266 LNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLL 1325

Query: 680  IRQFHFHGWPEV-GIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALST 738
            +R F F  W      P   K  + ++A V K Q +SG+    VHC  G GR+GTFCA +T
Sbjct: 1326 VRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAT 1385

Query: 739  VLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
            VLE ++   ++DVF   K+LR  +P+MV+T++QY FCY V  EY++
Sbjct: 1386 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1431


>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
            precursor [Homo sapiens]
          Length = 1446

 Score =  404 bits (1039), Expect = e-112
 Identities = 214/586 (36%), Positives = 334/586 (56%), Gaps = 17/586 (2%)

Query: 205  TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 264
            T + +P + V  L + IN+    +   F++E+ +          +A  K++  + +R   
Sbjct: 867  TGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESF-----FEGWDATKKKDKVKGSRQEP 921

Query: 265  ILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNT 324
            +  YD  RV L P+ G P++DYINA++I+GY   N FIA QGPK E V DFWRM+W+++ 
Sbjct: 922  MPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHC 981

Query: 325  ATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 384
            ++IVM+T L E    KC++YWP+    TYG+I++ +     L +Y VR F +++ G    
Sbjct: 982  SSIVMITKLVEVGRVKCSRYWPEDSD-TYGDIKIMLVKTETLAEYVVRTFALERRGYSAR 1040

Query: 385  RKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFV 444
             +    + QFHFT+WP+ GVP+   G+L F+++VKA  P  AG IV+HCSAG GRTG ++
Sbjct: 1041 HE----VRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYI 1096

Query: 445  VIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTS 504
            V+D MLDM   E  VD+Y  V  + ++R  M+QT+ QY+FI+ A+LE  L G+T + V+ 
Sbjct: 1097 VLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSE 1156

Query: 505  LETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVLQIIPYE 562
             +   +++    P ++++ L EEF+ L S+   +  ++     LP N  KNR + ++P +
Sbjct: 1157 FKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD 1216

Query: 563  FNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVM 622
                 +    G+ N +Y+NA+  D Y +  ++I +  PL  T  DFWR+++++   SIVM
Sbjct: 1217 RCLPFLISTDGDSN-NYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVM 1275

Query: 623  LTELEERGQE-KCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQ-- 679
            L +L +      C QYWP  G   YG + VE       E    R   V N    +     
Sbjct: 1276 LNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLL 1335

Query: 680  IRQFHFHGWPEV-GIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALST 738
            +R F F  W      P   K  + ++A V K Q +SG+    VHC  G GR+GTFCA +T
Sbjct: 1336 VRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAT 1395

Query: 739  VLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
            VLE ++   ++DVF   K+LR  +P+MV+T++QY FCY V  EY++
Sbjct: 1396 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1441


>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
            precursor [Homo sapiens]
          Length = 1442

 Score =  398 bits (1022), Expect = e-110
 Identities = 214/592 (36%), Positives = 334/592 (56%), Gaps = 23/592 (3%)

Query: 205  TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 264
            T + +P + V  L + IN+    +   F++E+ +          +A  K++  + +R   
Sbjct: 857  TGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESF-----FEGWDATKKKDKVKGSRQEP 911

Query: 265  ILPYDHSRVHLTPVEGVPDSDYINASFIN------GYQEKNKFIAAQGPKEETVNDFWRM 318
            +  YD  RV L P+ G P++DYINA++I+      GY   N FIA QGPK E V DFWRM
Sbjct: 912  MPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRM 971

Query: 319  IWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQ 378
            +W+++ ++IVM+T L E    KC++YWP+    TYG+I++ +     L +Y VR F +++
Sbjct: 972  VWQEHCSSIVMITKLVEVGRVKCSRYWPEDSD-TYGDIKIMLVKTETLAEYVVRTFALER 1030

Query: 379  VGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVG 438
             G     +    + QFHFT+WP+ GVP+   G+L F+++VKA  P  AG IV+HCSAG G
Sbjct: 1031 RGYSARHE----VRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTG 1086

Query: 439  RTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDT 498
            RTG ++V+D MLDM   E  VD+Y  V  + ++R  M+QT+ QY+FI+ A+LE  L G+T
Sbjct: 1087 RTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGET 1146

Query: 499  ELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVL 556
             + V+  +   +++    P ++++ L EEF+ L S+   +  ++     LP N  KNR +
Sbjct: 1147 TIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSM 1206

Query: 557  QIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWK 616
             ++P +     +    G+ N +Y+NA+  D Y +  ++I +  PL  T  DFWR+++++ 
Sbjct: 1207 DVLPPDRCLPFLISTDGDSN-NYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYG 1265

Query: 617  SCSIVMLTELEERGQE-KCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTREN 675
              SIVML +L +      C QYWP  G   YG + VE       E    R   V N    
Sbjct: 1266 CTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRL 1325

Query: 676  KSRQ--IRQFHFHGWPEV-GIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGT 732
            +     +R F F  W      P   K  + ++A V K Q +SG+    VHC  G GR+GT
Sbjct: 1326 QEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGT 1385

Query: 733  FCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
            FCA +TVLE ++   ++DVF   K+LR  +P+MV+T++QY FCY V  EY++
Sbjct: 1386 FCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1437


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,842,143
Number of Sequences: 37866
Number of extensions: 1354308
Number of successful extensions: 6071
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 136
Number of HSP's successfully gapped in prelim test: 69
Number of HSP's that attempted gapping in prelim test: 4117
Number of HSP's gapped (non-prelim): 944
length of query: 793
length of database: 18,247,518
effective HSP length: 110
effective length of query: 683
effective length of database: 14,082,258
effective search space: 9618182214
effective search space used: 9618182214
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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