Search of human proteins with 18105042

Search of human proteins with 18105042

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|18105042 GRB2-associated binding protein 2 isoform a [Homo
sapiens]
         (676 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|18105042 GRB2-associated binding protein 2 isoform a [Homo sa...  1380   0.0  
gi|6912460 GRB2-associated binding protein 2 isoform b [Homo sap...  1298   0.0  
gi|46370073 GRB2-associated binding protein 1 isoform b [Homo sa...   431   e-120
gi|46370071 GRB2-associated binding protein 1 isoform a [Homo sa...   415   e-116
gi|83716021 GRB2-associated binding protein family, member 4 [Ho...   362   e-100
gi|18079323 Gab3 protein isoform 2 [Homo sapiens]                     302   6e-82
gi|126091130 Gab3 protein isoform 1 [Homo sapiens]                    298   1e-80
gi|154146216 pleckstrin homology domain containing, family A (ph...    56   1e-07
gi|154354979 myosin X [Homo sapiens]                                   55   2e-07
gi|50234893 pleckstrin homology domain containing, family A (pho...    52   2e-06
gi|31377720 pleckstrin homology domain containing, family A (pho...    52   2e-06
gi|5031805 insulin receptor substrate 1 [Homo sapiens]                 51   3e-06
gi|110431370 espin [Homo sapiens]                                      49   2e-05
gi|154146189 dedicator of cytokinesis 10 [Homo sapiens]                49   2e-05
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        48   3e-05
gi|221219026 pleckstrin homology-like domain, family B, member 1...    47   6e-05
gi|239752594 PREDICTED: hypothetical protein, partial [Homo sapi...    47   6e-05
gi|156616273 pleckstrin [Homo sapiens]                                 47   6e-05
gi|91982772 mucin 17 [Homo sapiens]                                    47   6e-05
gi|55741447 pleckstrin homology domain containing, family H (wit...    47   6e-05
gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Ho...    47   8e-05
gi|197313732 pleckstrin homology-like domain, family B, member 2...    45   2e-04
gi|197313730 pleckstrin homology-like domain, family B, member 2...    45   2e-04
gi|197313728 pleckstrin homology-like domain, family B, member 2...    45   2e-04
gi|21955172 pleckstrin homology-like domain, family B, member 2 ...    45   2e-04
gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [...    45   2e-04
gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [...    45   2e-04
gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [H...    45   2e-04
gi|24432056 hypothetical protein LOC144717 [Homo sapiens]              45   2e-04
gi|46391075 hypothetical protein LOC79949 [Homo sapiens]               45   3e-04

>gi|18105042 GRB2-associated binding protein 2 isoform a [Homo
           sapiens]
          Length = 676

 Score = 1380 bits (3573), Expect = 0.0
 Identities = 676/676 (100%), Positives = 676/676 (100%)

Query: 1   MSGGGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRI 60
           MSGGGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRI
Sbjct: 1   MSGGGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRI 60

Query: 61  INLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQ 120
           INLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQ
Sbjct: 61  INLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQ 120

Query: 121 AEESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHM 180
           AEESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHM
Sbjct: 121 AEESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHM 180

Query: 181 QPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCVNG 240
           QPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCVNG
Sbjct: 181 QPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCVNG 240

Query: 241 ISGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFKTPSN 300
           ISGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFKTPSN
Sbjct: 241 ISGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFKTPSN 300

Query: 301 TLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNAMTVATPGDSAIAPPPRPPKPSQ 360
           TLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNAMTVATPGDSAIAPPPRPPKPSQ
Sbjct: 301 TLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNAMTVATPGDSAIAPPPRPPKPSQ 360

Query: 361 AETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGESAG 420
           AETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGESAG
Sbjct: 361 AETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGESAG 420

Query: 421 RSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYIPMS 480
           RSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYIPMS
Sbjct: 421 RSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYIPMS 480

Query: 481 PGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELP 540
           PGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELP
Sbjct: 481 PGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELP 540

Query: 541 FKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGT 600
           FKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGT
Sbjct: 541 FKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGT 600

Query: 601 NSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQE 660
           NSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQE
Sbjct: 601 NSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQE 660

Query: 661 WTDVRQSSEPSKGAKL 676
           WTDVRQSSEPSKGAKL
Sbjct: 661 WTDVRQSSEPSKGAKL 676


>gi|6912460 GRB2-associated binding protein 2 isoform b [Homo
           sapiens]
          Length = 638

 Score = 1298 bits (3358), Expect = 0.0
 Identities = 638/638 (100%), Positives = 638/638 (100%)

Query: 39  MSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLV 98
           MSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLV
Sbjct: 1   MSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLV 60

Query: 99  AETEEDMNKWVQSICQICGFNQAEESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKS 158
           AETEEDMNKWVQSICQICGFNQAEESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKS
Sbjct: 61  AETEEDMNKWVQSICQICGFNQAEESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKS 120

Query: 159 SAPSHSSQPTLFTFEPPVSNHMQPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRAS 218
           SAPSHSSQPTLFTFEPPVSNHMQPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRAS
Sbjct: 121 SAPSHSSQPTLFTFEPPVSNHMQPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRAS 180

Query: 219 FLMRSDTAVQKLAQGNGHCVNGISGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHT 278
           FLMRSDTAVQKLAQGNGHCVNGISGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHT
Sbjct: 181 FLMRSDTAVQKLAQGNGHCVNGISGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHT 240

Query: 279 KGSLTGSETDNEDVYTFKTPSNTLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNA 338
           KGSLTGSETDNEDVYTFKTPSNTLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNA
Sbjct: 241 KGSLTGSETDNEDVYTFKTPSNTLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNA 300

Query: 339 MTVATPGDSAIAPPPRPPKPSQAETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNS 398
           MTVATPGDSAIAPPPRPPKPSQAETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNS
Sbjct: 301 MTVATPGDSAIAPPPRPPKPSQAETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNS 360

Query: 399 RLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPG 458
           RLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPG
Sbjct: 361 RLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPG 420

Query: 459 SSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLK 518
           SSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLK
Sbjct: 421 SSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLK 480

Query: 519 PDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSG 578
           PDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSG
Sbjct: 481 PDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSG 540

Query: 579 DSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSD 638
           DSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSD
Sbjct: 541 DSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSD 600

Query: 639 EKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAKL 676
           EKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAKL
Sbjct: 601 EKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAKL 638


>gi|46370073 GRB2-associated binding protein 1 isoform b [Homo
           sapiens]
          Length = 694

 Score =  431 bits (1107), Expect = e-120
 Identities = 286/719 (39%), Positives = 391/719 (54%), Gaps = 77/719 (10%)

Query: 4   GGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINL 63
           GG+VVC+GWLRKSPPEKKL+RYAWK+RWF+LRSGR++GDPDVLEYYKNDH+KKP+RII+L
Sbjct: 3   GGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDL 62

Query: 64  NFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQAEE 123
           N C+QVDAGLTFNKKE ++S++FDI T +R FYLVA++EE+MNKWV+ IC ICGFN  EE
Sbjct: 63  NLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEE 122

Query: 124 STDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPP-----VSN 178
             D ++   S+   P   P  ++           ++ PS  +  +  T  PP     V  
Sbjct: 123 --DPVKPPGSSLQAPADLPLAIN-----------TAPPSTQADSSSATLPPPYQLINVPP 169

Query: 179 HMQPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCV 238
           H++       PQ+YL L  C S++ E  R+ + S  + +S    +D         +    
Sbjct: 170 HLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSK 229

Query: 239 NGISG--QVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFK 296
           +G++G  Q    Y  P     +     S Y+LPRS +     K S + +E D E +Y F 
Sbjct: 230 HGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGE-LYVFN 288

Query: 297 TPSNTLCREFGDLLVD-NMDVPATPLSAYQIPRTF---TLDKNHNAMTVATPGDSAIAPP 352
           TPS T   E     V  + D+P TP + YQIPRTF   TL +     T+         PP
Sbjct: 289 TPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPD------IPP 342

Query: 353 PRPPKPSQAETPRWGSPQQRPPISENSRSVAAT--IP-------RRNTLPAMDNSRLHR- 402
           PRPPKP  A      SP +   I   +    ++  IP       R NT+  +D ++L + 
Sbjct: 343 PRPPKPHPAHD---RSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKD 399

Query: 403 ASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTL 462
           ASS + Y+ P+        S E   +     +   + VG   S   ++NYVPMNP S   
Sbjct: 400 ASSQDCYDIPRAFPSDRSSSLEGFHNHFK--VKNVLTVGSVSSEELDENYVPMNPNSPPR 457

Query: 463 LAMERAGDNSQSV-YIPMSPGAHHFDS----------LGYPSTTLPVHRGPSRGSEIQPP 511
                  +  Q   Y+PM+PG   F S          +G+ S+     R P   ++ +PP
Sbjct: 458 QHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPP 517

Query: 512 PVNRNLKPDRKAKPTPLDLRNNTVIDEL--PFKSPITKSWSRANHTFNSSSSQYCRPIST 569
           PV+RNLKPDRK KP PL+++     +EL  P +SPIT+S++R +  F  S     RP S 
Sbjct: 518 PVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSP----RPDSV 573

Query: 570 QSIT-STDSGDSEENYVPMQNPVSASPVPS--------GTNSPAPK-KSTGSVDYLALDF 619
            S T S+DS DSEENYVPM NP  +S  P+        G +SP  K K    V+YL LD 
Sbjct: 574 HSTTSSSDSHDSEENYVPM-NPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDL 632

Query: 620 QPSSPSPHRKPSTS---SVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAK 675
                +P RK  +S   S  +DE+VDYV VD++KT AL++T + WTD RQS+E    AK
Sbjct: 633 DSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPAK 691


>gi|46370071 GRB2-associated binding protein 1 isoform a [Homo
           sapiens]
          Length = 724

 Score =  415 bits (1066), Expect = e-116
 Identities = 286/749 (38%), Positives = 391/749 (52%), Gaps = 107/749 (14%)

Query: 4   GGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINL 63
           GG+VVC+GWLRKSPPEKKL+RYAWK+RWF+LRSGR++GDPDVLEYYKNDH+KKP+RII+L
Sbjct: 3   GGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDL 62

Query: 64  NFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQAEE 123
           N C+QVDAGLTFNKKE ++S++FDI T +R FYLVA++EE+MNKWV+ IC ICGFN  EE
Sbjct: 63  NLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEE 122

Query: 124 STDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPP-----VSN 178
             D ++   S+   P   P  ++           ++ PS  +  +  T  PP     V  
Sbjct: 123 --DPVKPPGSSLQAPADLPLAIN-----------TAPPSTQADSSSATLPPPYQLINVPP 169

Query: 179 HMQPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCV 238
           H++       PQ+YL L  C S++ E  R+ + S  + +S    +D         +    
Sbjct: 170 HLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSK 229

Query: 239 NGISG--QVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFK 296
           +G++G  Q    Y  P     +     S Y+LPRS +     K S + +E D E +Y F 
Sbjct: 230 HGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGE-LYVFN 288

Query: 297 TPSNTLCREFGDLLVD-NMDVPATPLSAYQIPRTF---TLDKNHNAMTVATPGDSAIAPP 352
           TPS T   E     V  + D+P TP + YQIPRTF   TL +     T+         PP
Sbjct: 289 TPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPD------IPP 342

Query: 353 PRPPKPSQAETPRWGSPQQRPPISENSRSVAAT--IP-------RRNTLPAMDNSRLHR- 402
           PRPPKP  A      SP +   I   +    ++  IP       R NT+  +D ++L + 
Sbjct: 343 PRPPKPHPAHD---RSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKD 399

Query: 403 ASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTL 462
           ASS + Y+ P+        S E   +     +   + VG   S   ++NYVPMNP S   
Sbjct: 400 ASSQDCYDIPRAFPSDRSSSLEGFHNHFK--VKNVLTVGSVSSEELDENYVPMNPNSPPR 457

Query: 463 LAMERAGDNSQSV-YIPMSPGAHHFDS----------LGYPSTTLPVHRGPSRGSEIQPP 511
                  +  Q   Y+PM+PG   F S          +G+ S+     R P   ++ +PP
Sbjct: 458 QHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPP 517

Query: 512 PVNRNLKPD------------------------------RKAKPTPLDLRNNTVIDEL-- 539
           PV+RNLKPD                              RK KP PL+++     +EL  
Sbjct: 518 PVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQA 577

Query: 540 PFKSPITKSWSRANHTFNSSSSQYCRPISTQSIT-STDSGDSEENYVPMQNPVSASPVPS 598
           P +SPIT+S++R +  F  S     RP S  S T S+DS DSEENYVPM NP  +S  P+
Sbjct: 578 PVRSPITRSFARDSSRFPMSP----RPDSVHSTTSSSDSHDSEENYVPM-NPNLSSEDPN 632

Query: 599 --------GTNSPAPK-KSTGSVDYLALDFQPSSPSPHRKPSTS---SVTSDEKVDYVQV 646
                   G +SP  K K    V+YL LD      +P RK  +S   S  +DE+VDYV V
Sbjct: 633 LFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVV 692

Query: 647 DKEKTQALQNTMQEWTDVRQSSEPSKGAK 675
           D++KT AL++T + WTD RQS+E    AK
Sbjct: 693 DQQKTLALKSTREAWTDGRQSTESETPAK 721


>gi|83716021 GRB2-associated binding protein family, member 4 [Homo
           sapiens]
          Length = 574

 Score =  362 bits (930), Expect = e-100
 Identities = 187/288 (64%), Positives = 220/288 (76%), Gaps = 15/288 (5%)

Query: 5   GDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLN 64
           G V+ +GWLRKSPPEKKLR +AW+KRWFILR G+ S DPDVLEYYKND SKKPLR INLN
Sbjct: 38  GHVLYSGWLRKSPPEKKLRLFAWRKRWFILRRGQTSSDPDVLEYYKNDGSKKPLRTINLN 97

Query: 65  FCEQVDAGLT--FNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQAE 122
            CEQ+D  +T  FNKKE+Q  ++FDIKTSERTFYLVAET EDMN+WVQSICQICGF Q E
Sbjct: 98  LCEQLDVDVTLNFNKKEIQKGYMFDIKTSERTFYLVAETREDMNEWVQSICQICGFRQ-E 156

Query: 123 ESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHMQP 182
           EST  L N+SSA HG  SSPAE S S QHL +E++             T EPPVS+ + P
Sbjct: 157 ESTGFLGNISSASHGLCSSPAEPSCSHQHLPQEQEP------------TSEPPVSHCVPP 204

Query: 183 TLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCVNGIS 242
           T    AP   L  HQ  S+RAE+ARSASFSQG+ A F+MR +TA+Q LAQ +G+ V+G+S
Sbjct: 205 TWPIPAPPGCLRSHQHASQRAEHARSASFSQGSEAPFIMRRNTAMQNLAQHSGYSVDGVS 264

Query: 243 GQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNE 290
           G +HGF+SL KPS+HN EFR ST+ +P SLASHGHT+GSLTGSE DNE
Sbjct: 265 GHIHGFHSLSKPSQHNAEFRGSTHRIPWSLASHGHTRGSLTGSEADNE 312



 Score =  295 bits (755), Expect = 9e-80
 Identities = 161/267 (60%), Positives = 195/267 (73%), Gaps = 9/267 (3%)

Query: 410 EYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTLLAMERAG 469
           +Y Q GG +A R AESM +GV SFLPG+ +VG SDS  SE + VPMNPGS TL A+++AG
Sbjct: 317 KYTQHGGGNASRPAESMHEGVCSFLPGRTLVGLSDSIASEGSCVPMNPGSPTLPAVKQAG 376

Query: 470 DNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLD 529
           D+SQ V IP+      FD LG P T L +H+  S+G E+Q PPVNR+LKP++KA PTP +
Sbjct: 377 DDSQGVCIPVGSCLVRFDLLGSPLTELSMHQDLSQGHEVQLPPVNRSLKPNQKANPTPPN 436

Query: 530 LRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQN 589
           LRNN VI+EL FK P+T+ WS  +HTF+SSSSQ+  PISTQSIT+TDS DS E Y+   N
Sbjct: 437 LRNNRVINELSFKPPVTEPWSGTSHTFDSSSSQH--PISTQSITNTDSEDSGERYL-FPN 493

Query: 590 PVSASPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKE 649
           P SA PV  GT+S AP +STG++ Y ALDFQPS      KPS  SVTS +KVDYVQVD E
Sbjct: 494 PASAFPVSGGTSSSAPPRSTGNIHYAALDFQPS------KPSIGSVTSGKKVDYVQVDLE 547

Query: 650 KTQALQNTMQEWTDVRQSSEPSKGAKL 676
           KTQALQ TM E   +RQSSEP +GAKL
Sbjct: 548 KTQALQKTMHEQMCLRQSSEPPRGAKL 574


>gi|18079323 Gab3 protein isoform 2 [Homo sapiens]
          Length = 586

 Score =  302 bits (774), Expect = 6e-82
 Identities = 224/674 (33%), Positives = 338/674 (50%), Gaps = 104/674 (15%)

Query: 5   GDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLN 64
           GD VCTGWL KSPPE+KL+RYAW+KRWF+LR GRMSG+PDVLEYY+N HS KP+R+I+L+
Sbjct: 4   GDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS 63

Query: 65  FCE-QVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQAEE 123
            C      G +F +KE Q++FVF +KT+ RTFYLVA+TE++M  WV SI Q+C     E+
Sbjct: 64  ECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLED 123

Query: 124 STDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHMQPT 183
             DS+ ++S        +P+ L  SS        S   +H++  +L   +P  + +   T
Sbjct: 124 GADSMESLS-------YTPSSLQPSS------ASSLLTAHAASSSLPRDDP--NTNAVAT 168

Query: 184 LSTSAPQEYLYL-HQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCVNGIS 242
             T +  E L+L    +    E  R    S  TR      SD ++++             
Sbjct: 169 EETRSESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQ------------- 215

Query: 243 GQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFKTPSNTL 302
                       +  +  F D    LP S   H    GS        ++V + +  +  +
Sbjct: 216 ------------ASFDDVFVDCLQPLPSSHLVHPSCHGS------GAQEVPSSRPQAALI 257

Query: 303 -CREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNAMTVATPGDSAIA--PPPRPPKPS 359
             RE      D++   ++PL    +  T  +DKN  ++         ++  PPPRPPKPS
Sbjct: 258 WSREINGPPRDHLS--SSPLLESSLSSTIQVDKNQGSLPCGAKELDIMSNTPPPRPPKPS 315

Query: 360 QAETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGESA 419
                R    ++    S + +     +PRR +L  +DN R  +A             +  
Sbjct: 316 HLSERR---QEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKA-------------DVE 359

Query: 420 GRSAESMSDGVGSFLPGKMI-VGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYIP 478
           G+S       +   LP +   +  + S + ED+YVPM+P +    A       S   YIP
Sbjct: 360 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAG---ASGLGPHCSPDDYIP 416

Query: 479 MSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDE 538
           M+ G     S+  P   LP        + ++PPPVNR+LKP RK++P PLDLRN ++I E
Sbjct: 417 MNSG-----SISSPLPELP--------ANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIRE 463

Query: 539 LPFKSPITKSWSRANHTFNSSSSQYCRP-----ISTQSITSTDSGDSEENYVPMQNPVSA 593
               + +T++      T   S + +  P      S +   +  S + EE+Y+ M+   +A
Sbjct: 464 ---HASLTRT-----RTVPCSRTSFLSPERNGINSARFFANPVSREDEESYIEMEEHRTA 515

Query: 594 SPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQA 653
           S + SG  +   K    S+DYLALDF  +SP+P ++     ++ +++VDYVQVD++KTQA
Sbjct: 516 SSLSSGALTWTKK---FSLDYLALDFNSASPAPMQQKLL--LSEEQRVDYVQVDEQKTQA 570

Query: 654 LQNTMQEWTDVRQS 667
           LQ+T QEWTD RQS
Sbjct: 571 LQSTKQEWTDERQS 584


>gi|126091130 Gab3 protein isoform 1 [Homo sapiens]
          Length = 587

 Score =  298 bits (763), Expect = 1e-80
 Identities = 224/675 (33%), Positives = 339/675 (50%), Gaps = 105/675 (15%)

Query: 5   GDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLN 64
           GD VCTGWL KSPPE+KL+RYAW+KRWF+LR GRMSG+PDVLEYY+N HS KP+R+I+L+
Sbjct: 4   GDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS 63

Query: 65  FCE-QVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQAEE 123
            C      G +F +KE Q++FVF +KT+ RTFYLVA+TE++M  WV SI Q+C     E+
Sbjct: 64  ECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLED 123

Query: 124 -STDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHMQP 182
            + DS+ ++S        +P+ L  SS        S   +H++  +L   +P  + +   
Sbjct: 124 GAADSMESLS-------YTPSSLQPSS------ASSLLTAHAASSSLPRDDP--NTNAVA 168

Query: 183 TLSTSAPQEYLYL-HQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCVNGI 241
           T  T +  E L+L    +    E  R    S  TR      SD ++++            
Sbjct: 169 TEETRSESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQ------------ 216

Query: 242 SGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFKTPSNT 301
                        +  +  F D    LP S   H    GS        ++V + +  +  
Sbjct: 217 -------------ASFDDVFVDCLQPLPSSHLVHPSCHGS------GAQEVPSSRPQAAL 257

Query: 302 L-CREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNAMTVATPGDSAIA--PPPRPPKP 358
           +  RE      D++   ++PL    +  T  +DKN  ++         ++  PPPRPPKP
Sbjct: 258 IWSREINGPPRDHLS--SSPLLESSLSSTIQVDKNQGSLPCGAKELDIMSNTPPPRPPKP 315

Query: 359 SQAETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGES 418
           S     R    ++    S + +     +PRR +L  +DN R  +A             + 
Sbjct: 316 SHLSERR---QEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKA-------------DV 359

Query: 419 AGRSAESMSDGVGSFLPGKMI-VGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYI 477
            G+S       +   LP +   +  + S + ED+YVPM+P +    A       S   YI
Sbjct: 360 EGQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAG---ASGLGPHCSPDDYI 416

Query: 478 PMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVID 537
           PM+ G     S+  P   LP        + ++PPPVNR+LKP RK++P PLDLRN ++I 
Sbjct: 417 PMNSG-----SISSPLPELP--------ANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIR 463

Query: 538 ELPFKSPITKSWSRANHTFNSSSSQYCRP-----ISTQSITSTDSGDSEENYVPMQNPVS 592
           E    + +T++      T   S + +  P      S +   +  S + EE+Y+ M+   +
Sbjct: 464 E---HASLTRT-----RTVPCSRTSFLSPERNGINSARFFANPVSREDEESYIEMEEHRT 515

Query: 593 ASPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQ 652
           AS + SG  +   K    S+DYLALDF  +SP+P ++     ++ +++VDYVQVD++KTQ
Sbjct: 516 ASSLSSGALTWTKK---FSLDYLALDFNSASPAPMQQKLL--LSEEQRVDYVQVDEQKTQ 570

Query: 653 ALQNTMQEWTDVRQS 667
           ALQ+T QEWTD RQS
Sbjct: 571 ALQSTKQEWTDERQS 585


>gi|154146216 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 2 [Homo
           sapiens]
          Length = 425

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 48/170 (28%), Positives = 76/170 (44%), Gaps = 13/170 (7%)

Query: 24  RYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQDS 83
           R +WK+R+F L       D   + Y+K +  ++PLR I L    +    L  +   L   
Sbjct: 212 RKSWKRRFFAL-------DDFTICYFKCEQDREPLRTIFLKDVLKTHECLVKSGDLLMRD 264

Query: 84  FVFDIKTSERTFYLVAETEEDMNKWVQSI-CQICGFNQAEESTDSLRNVSSAGHGP---R 139
            +F+I TS RTFY+ A++ EDM+ W++ I   +         T   R++S    G     
Sbjct: 265 NLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQALKCHPRETSFSRSISLTRPGSSSLS 324

Query: 140 SSPAELSSSSQHLLRERKS--SAPSHSSQPTLFTFEPPVSNHMQPTLSTS 187
           S P  +    +  L E+K+   APS +S    +T  P     + P   TS
Sbjct: 325 SGPNSILCRGRPPLEEKKALCKAPSVASSWQPWTPVPQAGEKLLPPGDTS 374


>gi|154354979 myosin X [Homo sapiens]
          Length = 2058

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 32/106 (30%), Positives = 52/106 (49%), Gaps = 15/106 (14%)

Query: 11   GWL-RKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQV 69
            GWL +K      L R  WKKRWF+LR  +       L Y++ND  +K    + +   +++
Sbjct: 1217 GWLHKKGGGSSTLSRRNWKKRWFVLRQSK-------LMYFENDSEEKLKGTVEVRTAKEI 1269

Query: 70   DAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQI 115
                T            DI  ++RTF+L+AE+ ED ++W   + Q+
Sbjct: 1270 IDNTTKENG-------IDIIMADRTFHLIAESPEDASQWFSVLSQV 1308


>gi|50234893 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 1 [Homo
           sapiens]
          Length = 404

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 29/92 (31%), Positives = 52/92 (56%), Gaps = 21/92 (22%)

Query: 27  WKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNF------CEQVDAGLTFNKKEL 80
           WK+R+F L       D + + Y+K++  K+PLR+I L        C+Q D  +  N    
Sbjct: 208 WKRRYFQL-------DENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDN---- 256

Query: 81  QDSFVFDIKTSERTFYLVAETEEDMNKWVQSI 112
               +F+I T+ RTFY+ A++ E+M+ W++++
Sbjct: 257 ----LFEIVTTSRTFYVQADSPEEMHSWIKAV 284


>gi|31377720 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 1 [Homo
           sapiens]
          Length = 404

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 29/92 (31%), Positives = 52/92 (56%), Gaps = 21/92 (22%)

Query: 27  WKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNF------CEQVDAGLTFNKKEL 80
           WK+R+F L       D + + Y+K++  K+PLR+I L        C+Q D  +  N    
Sbjct: 208 WKRRYFQL-------DENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDN---- 256

Query: 81  QDSFVFDIKTSERTFYLVAETEEDMNKWVQSI 112
               +F+I T+ RTFY+ A++ E+M+ W++++
Sbjct: 257 ----LFEIVTTSRTFYVQADSPEEMHSWIKAV 284


>gi|5031805 insulin receptor substrate 1 [Homo sapiens]
          Length = 1242

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 37/140 (26%), Positives = 66/140 (47%), Gaps = 20/140 (14%)

Query: 3   GGGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKND-----HSKKP 57
           G  DV   G+LRK          +  KR+F+LR+   +G P  LEYY+N+      S  P
Sbjct: 9   GFSDVRKVGYLRKPK--------SMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP 60

Query: 58  LRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICG 117
            R I L  C  ++      + + ++  +  + T +  F + A++E + + W Q++ Q+  
Sbjct: 61  KRSIPLESCFNIN-----KRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQL-- 113

Query: 118 FNQAEESTDSLRNVSSAGHG 137
            N+A+   D    + + G G
Sbjct: 114 HNRAKGHHDGAAALGAGGGG 133



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 20/63 (31%), Positives = 32/63 (50%), Gaps = 10/63 (15%)

Query: 443 SDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTL-PVHRG 501
           S + +++D Y+PM+PG    +A   +G      Y+PMSP      S+  P   + P+ R 
Sbjct: 603 SSTLHTDDGYMPMSPG----VAPVPSGRKGSGDYMPMSP-----KSVSAPQQIINPIRRH 653

Query: 502 PSR 504
           P R
Sbjct: 654 PQR 656


>gi|110431370 espin [Homo sapiens]
          Length = 854

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 66/294 (22%), Positives = 105/294 (35%), Gaps = 34/294 (11%)

Query: 351 PPPRPPKPSQAETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHR-ASSCETY 409
           PPP PP  +Q   P  G P  +PP+   +  +   +  +N L  ++   L +  SSC+ +
Sbjct: 438 PPPPPPPGTQLPPPPPGYPAPKPPVGPQAADI--YMQTKNKLRHVETEALKKELSSCDGH 495

Query: 410 EYPQRGGESAGRSAESMSDGVGSF------LPGKMIVGRSDSTNSEDNYVPMNPGSSTLL 463
           +  +R   S    A S     G +       PG+ +  R    +SE+    +        
Sbjct: 496 DGLRRQDSSRKPRAFSKQPSTGDYYRQLGRCPGETLAARPGMAHSEE----VRARQPARA 551

Query: 464 AMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKA 523
              R G        P + G+    S    +  LP +  P+  +    P  +R L P    
Sbjct: 552 GCPRLG--------PAARGSLEGPSAPPQAALLPGNHVPNGCA--ADPKASRELPPPPPP 601

Query: 524 KPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEEN 583
            P PL    ++     P   P+  +        +SSS+   +  +  S T    GD+ E 
Sbjct: 602 PPPPLPEAASSPPPAPPL--PLESAGPGCGQRRSSSSTGSTKSFNMMSPT----GDNSEL 655

Query: 584 YVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTS 637
              ++   S  P P            G        FQP SP P   P+ S V S
Sbjct: 656 LAEIKAGKSLKPTPQSKGLTTVFSGIGQP-----AFQPDSPLPSVSPALSPVRS 704



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 29/118 (24%), Positives = 40/118 (33%), Gaps = 21/118 (17%)

Query: 296 KTPSNTLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNH--NAMTVATPGDSAIAPPP 353
           + P+   C   G     +++ P+ P      P+   L  NH  N           + PPP
Sbjct: 546 RQPARAGCPRLGPAARGSLEGPSAP------PQAALLPGNHVPNGCAADPKASRELPPPP 599

Query: 354 RPPKPSQAETPRWGSPQQRPPI-----------SENSRSVAATIPRRNTLPAMDNSRL 400
            PP P   E     SP   PP+             +S S  +T       P  DNS L
Sbjct: 600 PPPPPPLPEAA--SSPPPAPPLPLESAGPGCGQRRSSSSTGSTKSFNMMSPTGDNSEL 655


>gi|154146189 dedicator of cytokinesis 10 [Homo sapiens]
          Length = 2186

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 48/169 (28%), Positives = 80/169 (47%), Gaps = 30/169 (17%)

Query: 2   SGGGDVVCTGWLRK----SPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDH-SKK 56
           +GG  V  +GWL K    S     +   ++KKR+F L   ++  +  ++ +YK++  SK+
Sbjct: 177 AGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRYFQLT--QLPDNSYIMNFYKDEKISKE 234

Query: 57  PLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFY-LVAETEEDMNKWVQSICQI 115
           P   I L+ C  V       K      + F++K ++ T++ L AETE DM++W+ ++ +I
Sbjct: 235 PKGCIFLDSCTGVVQNNRLRK------YAFELKMNDLTYFVLAAETESDMDEWIHTLNRI 288

Query: 116 C-----GFNQAEEST-------DSLRNVSSAGHGPRSSPAELSSSSQHL 152
                 G  Q   ST       DSL N  +       +P E  SS  +L
Sbjct: 289 LQISPEGPLQGRRSTELTDLGLDSLDNSVTC----ECTPEETDSSENNL 333


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 99/419 (23%), Positives = 150/419 (35%), Gaps = 57/419 (13%)

Query: 254  PSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFKTPSNTLCREFGDLLVDN 313
            PS   T    ++ +L    ++H     ++ GS T           S T  R    L   N
Sbjct: 2324 PSSSRTPQAPASANLVGPRSAHATAPVNIAGSRT----AAALAPASLTSARMAPALSGAN 2379

Query: 314  MDVPATPLSAYQIPRTFT----LDKNHNAMTVATPGDSAIAPPPRPPKPSQAETPRWG-S 368
            +  P  PLSAY+     T    LD+  +    + P  S +    R P PS     R G +
Sbjct: 2380 LTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSE-RAPSPSS----RMGQA 2434

Query: 369  PQQR--PPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGESAGRSAESM 426
            P Q   PP  +  RS   +          D SR   A +      P  G +S    A + 
Sbjct: 2435 PSQSLLPPAQDQPRSPVPSA-------FSDQSRCLIAQTT-----PVAGSQSLSSGAVAT 2482

Query: 427  SDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGS---STLLAMERAGDN-SQSVYIPMSPG 482
            +        G + V      +S+    P + G+   S L A++ A +  S S     S  
Sbjct: 2483 TTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSS 2542

Query: 483  AHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLD---LRNNTVIDEL 539
            +    S    S++       S GS +   PV   +   R   PTP     +R     +  
Sbjct: 2543 SSSSSSSSSSSSSSGSSSSDSEGSSL---PVQPEVALKRVPSPTPAPKEAVREGRPPEPT 2599

Query: 540  PFKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSG 599
            P K    +S S ++ + +SSSS      S+ S +S+ S  S  +     +P  A P P  
Sbjct: 2600 PAKRK-RRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQA 2658

Query: 600  TNSPA--------------PKKSTGSV-DYLALDFQP---SSPSPHRKPSTSSVTSDEK 640
               PA              P+K   S+ D  +L + P     PSP   P     +S E+
Sbjct: 2659 LPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSER 2717



 Score = 33.9 bits (76), Expect = 0.51
 Identities = 60/274 (21%), Positives = 90/274 (32%), Gaps = 24/274 (8%)

Query: 333 DKNHNAMTVATPGDSAIAPPPRPPKPSQAETPR-WGSPQQRPPISENSRSVAATIPRRNT 391
           DK   + T  +P     +  P PP P+     R  GSPQ   P++    S     P    
Sbjct: 341 DKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQ---PLATTPLSQEPVNPPSEA 397

Query: 392 LPAMDNSRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDN 451
            P  D S             P +  E   +S+ S S       P    V R  S++ E  
Sbjct: 398 SPTRDRS-------------PPKSPEKLPQSSSSESSPPS---PQPTKVSRHASSSPESP 441

Query: 452 YVPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDS--LGYPSTTLPVHRGPSRGSEIQ 509
                PGS   ++      N             H  S  +G   +     RG SR     
Sbjct: 442 KPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPT 501

Query: 510 PPPVNRNLKPD-RKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYCRPIS 568
               +R+  P  R+++      R+ +       +SP    WSR+ +T     S+  R   
Sbjct: 502 KRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGR 561

Query: 569 TQSITSTDSGDSEENYVPMQNPVSASPVPSGTNS 602
           + S +    G S     P +   S S  P+   S
Sbjct: 562 SHSRSPATRGRSRSR-TPARRGRSRSRTPARRRS 594



 Score = 33.9 bits (76), Expect = 0.51
 Identities = 106/516 (20%), Positives = 182/516 (35%), Gaps = 66/516 (12%)

Query: 119  NQAEESTDSLRNVSSAGHGPRSSPA--ELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPV 176
            +QA      + +++S+  GP  SP   ELS+S    LRE    +P        F    P+
Sbjct: 1289 SQASLEAVEVPSMASSWGGPHFSPEHKELSNSP---LRENSFGSPLE------FRNSGPL 1339

Query: 177  SNHMQPTLSTSAPQEYLYLHQCISRRAENARSASFS-QGTRASFLMRSDTAVQKLAQGNG 235
               M    S+   ++   L+     + E   S     Q TR+S    S+ +   + +   
Sbjct: 1340 GTEMNTGFSSEVKED---LNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGM 1396

Query: 236  HCVNGISGQVHGFYSLPK-PSRHNT------EFRDSTYDLPRSLASHGHTKG-------- 280
                 IS  V    ++P+ PSR  +      E +D     P   +  G + G        
Sbjct: 1397 SSNQSISSPV--LDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTP 1454

Query: 281  ---SLTGSETDNEDVYTFKTPSNTLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHN 337
               SL+GS    +D+   +TPS    R   D   +   +P TP    + P +  L+    
Sbjct: 1455 SRHSLSGSSPGMKDIP--RTPSRG--RSECDSSPEPKALPQTPRPRSRSPSSPELNNKCL 1510

Query: 338  AMTVATPGDSAIAPPPRPPKPSQAETPRWGSPQQ---RPPISENSRSVAATIPRRNTLPA 394
                   G  +        +    +  R GS Q+   +P  S   RS + + P       
Sbjct: 1511 TPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTR 1570

Query: 395  MDNSRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVP 454
                +  R+ S    +   R      RS  S        +  K        + S+ +  P
Sbjct: 1571 TPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPE------VKDKPRAAPRAQSGSDSSPEP 1624

Query: 455  MNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVN 514
              P    L    R+G +S+       P      S        P  R   RGS   P P  
Sbjct: 1625 KAPAPRALPRRSRSGSSSKG----RGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKT 1680

Query: 515  RNLKPDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYCRPISTQSITS 574
            ++  P R+        R++    EL  K+ +++    A+ +  + S    R   + S++S
Sbjct: 1681 KSRTPPRR--------RSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSS 1732

Query: 575  TDSGDSEENYVPMQNPVSASPVPSGTN----SPAPK 606
             +   +E++    +   ++SP    T+    SP+PK
Sbjct: 1733 PE--PAEKSRSSRRRRSASSPRTKTTSRRGRSPSPK 1766



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 56/229 (24%), Positives = 83/229 (36%), Gaps = 34/229 (14%)

Query: 389 RNTLPAMDNSRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNS 448
           R+T PA  + R HR++S ++         S+  ++ S S    +      + GRS S  S
Sbjct: 249 RSTTPAPKSRRAHRSTSADS--------ASSSDTSRSRSRSAAAKTHTTALAGRSPSPAS 300

Query: 449 ----EDNYVPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSR 504
               E +     PG++   + +R      +   P SP           S T P    P R
Sbjct: 301 GRRGEGDAPFSEPGTT---STQRPSSPETATKQPSSPYEDKDKDKKEKSATRP-SPSPER 356

Query: 505 GSEIQPPPVNRNLKPDRK-AKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQY 563
            S    PP    L  +R    P PL     T + + P   P     S A+ T + S    
Sbjct: 357 SSTGPEPPAPTPLLAERHGGSPQPL---ATTPLSQEPVNPP-----SEASPTRDRSP--- 405

Query: 564 CRPISTQSITSTDSGDSEENYVPMQNPVSAS-PVPSGTNSPAPKKSTGS 611
             P S + +  + S +S     P   P   S    S   SP P  + GS
Sbjct: 406 --PKSPEKLPQSSSSESSP---PSPQPTKVSRHASSSPESPKPAPAPGS 449


>gi|221219026 pleckstrin homology-like domain, family B, member 1
            isoform b [Homo sapiens]
          Length = 1319

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 33/106 (31%), Positives = 49/106 (46%), Gaps = 10/106 (9%)

Query: 8    VCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCE 67
            VC G+L K   + K    +WKKRWF+    + +     L YY + H  K   +I     E
Sbjct: 1211 VCRGYLVKMGGKIK----SWKKRWFVFDRLKRT-----LSYYVDKHETKLKGVIYFQAIE 1261

Query: 68   QVDAG-LTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSI 112
            +V    L    K    +  F +KT +R +Y+VA + E M  W+  I
Sbjct: 1262 EVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVI 1307


>gi|239752594 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 673

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 79/319 (24%), Positives = 117/319 (36%), Gaps = 37/319 (11%)

Query: 326 IPRTFTLDKNHNAMTVATPGDSAIAPPPRPPKPSQAETPRWGSPQQRPPISENSRSVAAT 385
           +P T +L K  +  ++ T   S  +P   PP+ S   +P   S    P  +   R+    
Sbjct: 196 MPSTASLTKMDSTASI-TRTLSRASPTGTPPRASPTGSPPRASLSMMPSTALLIRTPPRA 254

Query: 386 IPR----RNTLPAMDNSRLHRASSCETYEYPQRGGESA--GRSAESMSDGVGSFLPGKMI 439
            P     R +L  MD++    AS   T   P     +    R++ SM+    S +    +
Sbjct: 255 SPTGMLSRTSLTKMDST----ASITRTPSRPSTASPTGTPSRASLSMTPSTASLM---RM 307

Query: 440 VGRSDSTN--SEDNYVPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLP 497
           + R+  T   S  +   M+  +S      RA        I  +P        G PST  P
Sbjct: 308 LPRASPTGMLSRTSLTKMDSTASISRTPPRAS-------ITRTPS--RASPTGKPSTASP 358

Query: 498 VHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFN 557
               PSR S    P           A PT    R +      P  + +T+   RA+ T  
Sbjct: 359 TGT-PSRASPTGSPSTASLTGLSSTASPTGTPPRASPT--GTPSTASLTRKPPRASPT-- 413

Query: 558 SSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLAL 617
                    +S  SIT  DS  S     P  +P    P  S T +P+    TG+    + 
Sbjct: 414 -------GMLSRTSITKMDSTASPTRTPPRASPTGTPPRASPTGTPSRASPTGTQSTASP 466

Query: 618 DFQPSSPSPHRKPSTSSVT 636
              PS+ SP   PST+S T
Sbjct: 467 TGSPSTASPTGSPSTASPT 485



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 75/311 (24%), Positives = 111/311 (35%), Gaps = 39/311 (12%)

Query: 347 SAIAPPPRPPKPSQAETPRWGSPQQRPPISENSRSVAATI---------PRRNTLPAMDN 397
           S  +P   PP+ S   TP   S  ++PP +  +  ++ T          P R    A   
Sbjct: 381 STASPTGTPPRASPTGTPSTASLTRKPPRASPTGMLSRTSITKMDSTASPTRTPPRASPT 440

Query: 398 SRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNP 457
               RAS   T   P R   +  +S  S +    +  P       S + +     +   P
Sbjct: 441 GTPPRASPTGT---PSRASPTGTQSTASPTGSPSTASPTGSPSTASPTGSPSRASLTRTP 497

Query: 458 GSSTLLAME------RAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPP 511
             ++L  ME      R    +   + P +         G PST L +   PSR +  + P
Sbjct: 498 SRASLTKMESTASITRTPSRASPTWTPSTASP-----TGSPSTALAMG-SPSRAALTRTP 551

Query: 512 P-VNRNLKPDRKAKPTP----LDLRNNTVI-DELPFKSPITKSWSRANHTFNSSSSQYCR 565
              +    P R +  TP    L    +TV+   +P  +  T   SR + T   SS+   +
Sbjct: 552 SRASLTRTPSRASLTTPSRASLTRTPSTVLLTRMPPSASPTGMPSRTSPTGMPSSALLTK 611

Query: 566 PISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQPSSPS 625
             ST SIT T    S     P  +P    P  S T +P     TG+         P   S
Sbjct: 612 MDSTASITRTPPRASPTETPPRASPTGTPPRASPTGTPPRASPTGT---------PPRAS 662

Query: 626 PHRKPSTSSVT 636
           P   PS +S T
Sbjct: 663 PTGTPSRASPT 673



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 86/347 (24%), Positives = 120/347 (34%), Gaps = 39/347 (11%)

Query: 316 VPATPLSAYQIPRTFTLDK-NHNAMTVATPGDSAIAPPPRPPKPSQAETPRWGSPQQRPP 374
           +P+T L     PR       +  ++T      S    P RP   S   TP   S    P 
Sbjct: 241 MPSTALLIRTPPRASPTGMLSRTSLTKMDSTASITRTPSRPSTASPTGTPSRASLSMTPS 300

Query: 375 ISENSRSVAATIPR----RNTLPAMDNSRL-----HRASSCETYEYPQRGGESAGRS--- 422
            +   R +    P     R +L  MD++        RAS   T       G+ +  S   
Sbjct: 301 TASLMRMLPRASPTGMLSRTSLTKMDSTASISRTPPRASITRTPSRASPTGKPSTASPTG 360

Query: 423 AESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNP--GSSTLLAMERAGDNSQSVYIPMS 480
             S +   GS  P    +    ST S     P     G+ +  ++ R    +    +   
Sbjct: 361 TPSRASPTGS--PSTASLTGLSSTASPTGTPPRASPTGTPSTASLTRKPPRASPTGMLSR 418

Query: 481 PGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPT-------PLDLRNN 533
                 DS   P+ T      P R S    PP         +A PT       P    + 
Sbjct: 419 TSITKMDSTASPTRT------PPRASPTGTPPRASPTGTPSRASPTGTQSTASPTGSPST 472

Query: 534 TVIDELPFKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSA 593
                 P  +  T S SRA+ T   S +   +  ST SIT T S  S     P   P +A
Sbjct: 473 ASPTGSPSTASPTGSPSRASLTRTPSRASLTKMESTASITRTPSRAS-----PTWTPSTA 527

Query: 594 SPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEK 640
           SP    T SP+   + GS    AL   PS  S  R PS +S+T+  +
Sbjct: 528 SP----TGSPSTALAMGSPSRAALTRTPSRASLTRTPSRASLTTPSR 570



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 38/136 (27%), Positives = 55/136 (40%), Gaps = 4/136 (2%)

Query: 502 PSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSS 561
           PSR S    P     L    +A  T    R +  +   P  + +T++  RA+ T   S +
Sbjct: 134 PSRASLSMTPSTAAALTMPSRASLTRTPPRASLTMT--PSTASLTRTPPRASPTGMPSRT 191

Query: 562 QYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQ- 620
                 ST S+T  DS  S    +   +P    P  S T SP P+ S   +   AL  + 
Sbjct: 192 SPTGMPSTASLTKMDSTASITRTLSRASPTGTPPRASPTGSP-PRASLSMMPSTALLIRT 250

Query: 621 PSSPSPHRKPSTSSVT 636
           P   SP    S +S+T
Sbjct: 251 PPRASPTGMLSRTSLT 266



 Score = 29.6 bits (65), Expect = 9.5
 Identities = 27/97 (27%), Positives = 38/97 (39%), Gaps = 9/97 (9%)

Query: 540 PFKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSG 599
           P  + +T+S SRA+ T   S +      ST +  +  S  S     P  +        S 
Sbjct: 116 PSTASLTRSPSRASLTTTPSRASLSMTPSTAAALTMPSRASLTRTPPRASLTMTPSTASL 175

Query: 600 TNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVT 636
           T +P     TG          PS  SP   PST+S+T
Sbjct: 176 TRTPPRASPTG---------MPSRTSPTGMPSTASLT 203


>gi|156616273 pleckstrin [Homo sapiens]
          Length = 350

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 28/91 (30%), Positives = 47/91 (51%), Gaps = 6/91 (6%)

Query: 23  RRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQD 82
           RR  WK R FILR      DP  L YY    ++ PL  I+L  C         N ++ ++
Sbjct: 257 RRKNWKVRKFILRE-----DPAYLHYYDPAGAEDPLGAIHLRGCVVTSVESNSNGRKSEE 311

Query: 83  SFVFDIKTSERT-FYLVAETEEDMNKWVQSI 112
             +F+I T++   ++L A T ++  +W+++I
Sbjct: 312 ENLFEIITADEVHYFLQAATPKERTEWIRAI 342


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 84/375 (22%), Positives = 136/375 (36%), Gaps = 59/375 (15%)

Query: 319  TPLSAYQIPRTFTLDKNHNAMTVATPGDS---------AIAPPPRPP-------KPSQAE 362
            TPL++  +  T  +    N ++  TP DS         A +PPP           P +  
Sbjct: 1160 TPLASMPVSTTLVVSSEANTLST-TPVDSKTQVATSTEASSPPPTAEVTSMPTSTPGERS 1218

Query: 363  TPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGESAGRS 422
            TP    P +  P++ +  S  +T P   + P          +S ET   P     + G S
Sbjct: 1219 TPLTSMPVRHTPVASSEASTLSTSPVDTSTPV--------TTSAETSSSPT---TAEGTS 1267

Query: 423  AESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTLLA--MERAGDNSQSVYIPMS 480
              + +   GS L   + V  +  T         +P +STLL   ++  G    S  +  S
Sbjct: 1268 LPTSTTSEGSTLLTSIPVSTTLVT---------SPEASTLLTTPVDTKGPVVTSNEVSSS 1318

Query: 481  PGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRK---AKPTPLDLRNNTVID 537
            P      S+  P++T    R P     +   PVN  L           TP+D        
Sbjct: 1319 PTPAEGTSM--PTSTYSEGRTP-----LTSIPVNTTLVASSAISILSTTPVDNSTPVTTS 1371

Query: 538  ELPFKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVP 597
                 SP T   S      NS+ S+   P+++  +++T    SE       + +SA+PV 
Sbjct: 1372 TEACSSPTT---SEGTSMPNSNPSEGTTPLTSIPVSTTPVVSSE------ASTLSATPVD 1422

Query: 598  SGTNSPAPKKSTGS-VDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQN 656
            + T      ++T S      +    S+PS  + P  S   S+  V   +     T  + +
Sbjct: 1423 TSTPGTTSAEATSSPTTAEGISIPTSTPSEGKTPLKSIPVSNTPVANSEASTLSTTPVDS 1482

Query: 657  TMQEWTDVRQSSEPS 671
                 T    SS P+
Sbjct: 1483 NSPVVTSTAVSSSPT 1497



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 80/400 (20%), Positives = 133/400 (33%), Gaps = 47/400 (11%)

Query: 283 TGSETDNEDVYTFKTPSNTLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNAMTVA 342
           T SE  +       T   T     G   + +M V  TP+++ +     T   +     V 
Sbjct: 426 TASEASSSPTTAEDTSIATSTPSEGSTPLTSMPVSTTPVASSEASNLSTTPVDSKTQ-VT 484

Query: 343 TPGDSAIAPPPRPPK------PSQAETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMD 396
           T  +++ +PP           PS+  TP         P++ +  S  +T P   + P   
Sbjct: 485 TSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVSTMPVASSEASTLSTTPVDTSTPVTT 544

Query: 397 NSRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMN 456
           +S    ASS  T           G S  + +   GS     M V      +SE +     
Sbjct: 545 SS---EASSSST--------TPEGTSIPTSTPSEGSTPLTNMPVSTRLVVSSEASTTSTT 593

Query: 457 PGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRN 516
           P  S       +  +S S                   T++P      RG+ I    V+  
Sbjct: 594 PADSNTFVTTSSEASSSSTTA--------------EGTSMPTSTYSERGTTITSMSVSTT 639

Query: 517 LKPDRKA---KPTPLDLRNN-TVIDELPFKSPITKSWSRANHTFNSSSSQYCRPISTQSI 572
           L    +A     TP+D     T   E    S   +  S    T+   S+    P+++  +
Sbjct: 640 LVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGST----PLTSMPV 695

Query: 573 TSTDSGDSEENYVPMQNPVSASPVPSGTN-SPAPKKSTGSVDYLALDFQPSSPSPHRKPS 631
            +T    SE + +      +++PV + T  S +P  + G+          S+PS    P 
Sbjct: 696 NTTLVASSEASTLSTTPVDTSTPVTTSTEASSSPTTADGA------SMPTSTPSEGSTPL 749

Query: 632 TSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPS 671
           TS   S   +   +     T  L  +    T    S  P+
Sbjct: 750 TSMPVSKTLLTSSEASTLSTTPLDTSTHITTSTEASCSPT 789



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 85/382 (22%), Positives = 142/382 (37%), Gaps = 66/382 (17%)

Query: 278  TKGSLTGSETDNEDVYTFKTPSNTLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHN 337
            T+ SL+ +  +   + T  +PS       G   + +M V  TP+ + ++    T   + N
Sbjct: 3375 TEASLSPTTAEGTSIPT-SSPSE------GTTPLASMPVSTTPVVSSEVNTLSTTPVDSN 3427

Query: 338  AM-TVATPGDSA--IAPPPRPPKPSQAE--TPRWGSPQQRPPISENSRSVAATIPRRNTL 392
             + T +T   S+  IA     P  + +E  TP    P    P++ +  S  +T P   + 
Sbjct: 3428 TLVTTSTEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLSTTPVASSEASTLSTTPVDTST 3487

Query: 393  PAMDNSRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNY 452
            P   +S  +  SS  T E       +AG  +  +++         M V  +   +SE + 
Sbjct: 3488 PVTTSSPTN--SSPTTAEVTSMPTSTAGEGSTPLTN---------MPVSTTPVASSEAST 3536

Query: 453  VPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPV----HRGPSRGSEI 508
            +   P  S       +  +S    + ++       S G  S T  +    +   S  S  
Sbjct: 3537 LSTTPVDSNTFVTSSSQASSSPATLQVTTMRMSTPSEGSSSLTTMLLSSTYVTSSEASTP 3596

Query: 509  QPPPVNRNL----KPDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYC 564
              P V+R+          + PTP +      +  LP  +P              S+    
Sbjct: 3597 STPSVDRSTPVTTSTQSNSTPTPPE------VITLPMSTPS-----------EVSTPLTI 3639

Query: 565  RPISTQSITSTDSGDSEENYVPMQNP------VSASPV-PSGTNSPAPKKSTGSVDYLAL 617
             P+ST S+T +++G +    V    P      VS+SPV P GT  P    S G       
Sbjct: 3640 MPVSTTSVTISEAGTASTLPVDTSTPVITSTQVSSSPVTPEGTTMPIWTPSEG------- 3692

Query: 618  DFQPSSPSPHRKPSTSSVTSDE 639
                S+P      ST+ VTS E
Sbjct: 3693 ----STPLTTMPVSTTRVTSSE 3710



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 62/317 (19%), Positives = 108/317 (34%), Gaps = 36/317 (11%)

Query: 358  PSQAETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGE 417
            PS+  TP    P    P++ +     +T P   + P   +++   +SS  T E       
Sbjct: 2805 PSETSTPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTTSTK--ASSSPTTAEGIVVPIS 2862

Query: 418  SAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYI 477
            +A   +  ++    S  P       + ST   D  +P+   +    +   A   S  +  
Sbjct: 2863 TASEGSTLLTSIPVSTTPVASSEASTLSTTPVDTSIPVTTSTEGSSSPTTAEGTSMPIST 2922

Query: 478  PMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVID 537
            P          +  P T++ V   P  GSE                  TP+D R      
Sbjct: 2923 P--------SEVSTPLTSILVSTVPVAGSEAS------------TLSTTPVDTRTPVTTS 2962

Query: 538  ELPFKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVP 597
                 SP T   +       S+  +   P+++ S+++     SE + +      +++PV 
Sbjct: 2963 AEASSSPTT---AEGTSMPISTPGERRTPLTSMSVSTMPVASSEASTLSRTPADTSTPVT 3019

Query: 598  SGT---NSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQAL 654
            + T   +SP   + TG           S+PS    P TS   S   V   +     T  +
Sbjct: 3020 TSTEASSSPTTAEGTG--------IPISTPSEGSTPLTSIPVSTTPVAIPEASTLSTTPV 3071

Query: 655  QNTMQEWTDVRQSSEPS 671
             +     T    SS P+
Sbjct: 3072 DSNSPVVTSTEVSSSPT 3088



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 71/351 (20%), Positives = 121/351 (34%), Gaps = 45/351 (12%)

Query: 318 ATPLSAYQIPRTFTLDKNHNAMTVATPGDSAIAPPPRPPKPSQAETPRWGSPQQRPPISE 377
           A+ LS   +  +  +  +  A + +T  +    P   P   S+  TP    P     +  
Sbjct: 528 ASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTP---SEGSTPLTNMPVSTRLVVS 584

Query: 378 NSRSVAATIPR-RNTLPAMDNSRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPG 436
           +  S  +T P   NT     +     +++ E    P       G +  SMS         
Sbjct: 585 SEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVST------ 638

Query: 437 KMIVGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTL 496
             +V  S+++      V  N   +T      +   ++   +P S     +     P T++
Sbjct: 639 -TLVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTST----YTEGSTPLTSM 693

Query: 497 PVHR---GPSRGSEIQPPPVNRNLK-------------PDRKAKPTPLDLRNNTVIDELP 540
           PV+      S  S +   PV+ +                D  + PT      +T +  +P
Sbjct: 694 PVNTTLVASSEASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTSMP 753

Query: 541 F-KSPITKSWSRANHT--------FNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPV 591
             K+ +T S +    T          +S+   C P +T+  +   S  SE + +    PV
Sbjct: 754 VSKTLLTSSEASTLSTTPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPLLTSIPV 813

Query: 592 SASPVPS---GTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDE 639
           S +PV S    T S  P  S   V         SSP+P    S  + T  E
Sbjct: 814 SITPVTSPEASTLSTTPVDSNSPV--TTSTEVSSSPTPAEGTSMPTSTYSE 862



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 90/419 (21%), Positives = 143/419 (34%), Gaps = 71/419 (16%)

Query: 319  TPLSAYQIPRTFTLDKNHNAMTVAT-PGDS---------AIAPPPRPP-------KPSQA 361
            TPL++   P + TL  N  A T++T P DS         A +PPP           PS+ 
Sbjct: 983  TPLTS--TPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTSTPSEG 1040

Query: 362  ETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASS--------CETYEYPQ 413
             TP    P     ++ +  S  +T P   + P    S+   +S+          TY    
Sbjct: 1041 STPLTRMPVSTTMVASSETSTLSTTPADTSTPVTTYSQASSSSTTADGTSMPTSTYSEGS 1100

Query: 414  RGGESAGRSAESMSDGVGSFLPGKMI----------VGRSDSTNSEDNYVPMNPG----- 458
                S   S   +     S L    +             S  T +E   +P +P      
Sbjct: 1101 TPLTSVPVSTRLVVSSEASTLSTTPVDTSIPVTTSTEASSSPTTAEGTSIPTSPPSEGTT 1160

Query: 459  -------SSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPS----TTLPVHRGPSRGSE 507
                   S+TL+    A   S +     +  A   ++   P     T++P      R + 
Sbjct: 1161 PLASMPVSTTLVVSSEANTLSTTPVDSKTQVATSTEASSPPPTAEVTSMPTSTPGERSTP 1220

Query: 508  IQPPPVNRNLKPDRKA---KPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYC 564
            +   PV        +A     +P+D             SP T   +    +  S  S   
Sbjct: 1221 LTSMPVRHTPVASSEASTLSTSPVDTSTPVTTSAETSSSPTTAEGTSLPTSTTSEGSTLL 1280

Query: 565  R--PISTQSITSTDSGD------SEENYVPMQNPVSASPVPS-GTNSPAPKKSTGSVDYL 615
               P+ST  +TS ++          +  V   N VS+SP P+ GT+ P    S G     
Sbjct: 1281 TSIPVSTTLVTSPEASTLLTTPVDTKGPVVTSNEVSSSPTPAEGTSMPTSTYSEGRTPLT 1340

Query: 616  ALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQN-TMQEWTDVRQSSEPSKG 673
            ++    +  +     S  S+ S   VD        T+A  + T  E T +  +S PS+G
Sbjct: 1341 SIPVNTTLVA----SSAISILSTTPVDNSTPVTTSTEACSSPTTSEGTSM-PNSNPSEG 1394



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 85/418 (20%), Positives = 145/418 (34%), Gaps = 53/418 (12%)

Query: 282  LTGSETDNEDVYTFKTP--SNTLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNAM 339
            L+ +  DN    T  T   S+    E   +   N     TPL++  +  T  +    + +
Sbjct: 1357 LSTTPVDNSTPVTTSTEACSSPTTSEGTSMPNSNPSEGTTPLTSIPVSTTPVVSSEASTL 1416

Query: 340  TV-----ATPGDSAIAPPPRPPK----------PSQAETPRWGSPQQRPPISENSRSVAA 384
            +      +TPG ++      P            PS+ +TP    P    P++ +  S  +
Sbjct: 1417 SATPVDTSTPGTTSAEATSSPTTAEGISIPTSTPSEGKTPLKSIPVSNTPVANSEASTLS 1476

Query: 385  TIPRRNTLPAMDNSRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSD 444
            T P  +  P + ++ +   SS  T         + G S    +   GS     + V  + 
Sbjct: 1477 TTPVDSNSPVVTSTAV---SSSPT--------PAEGTSIAISTPSEGSTALTSIPVSTTT 1525

Query: 445  STNSEDNYVPMNPG-SSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPS 503
              +SE N +   P  +ST +       +S +     S     +     P T+LPV     
Sbjct: 1526 VASSEINSLSTTPAVTSTPVTTYSQASSSPTTADGTSMQTSTYSEGSTPLTSLPVSTMLV 1585

Query: 504  RGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQY 563
              SE                  TP+D +           S   +  S    T +  S   
Sbjct: 1586 VSSEA------------NTLSTTPIDSKTQVTASTEASSSTTAEGSSMTISTPSEGSPLL 1633

Query: 564  CR-PISTQSITSTDSGDSEENYVPMQNP------VSASPVPS-GTNSPAPKKSTGSVDYL 615
               P+ST  + S ++       V   +P      VS+SP P+ GT+ P    + G     
Sbjct: 1634 TSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPTPAEGTSMPTSTYTEGRTPLT 1693

Query: 616  ALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKG 673
            ++  + ++P      ST S T  +    V    E   +   T  E T +  +S PS+G
Sbjct: 1694 SITVR-TTPVASSAISTLSTTPVDNSTPVTTSTEARSS--PTTSEGTSM-PNSTPSEG 1747



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 80/410 (19%), Positives = 142/410 (34%), Gaps = 59/410 (14%)

Query: 307  GDLLVDNMDVPATPLSAYQIPRTFTLDKNHNA-MTVATPGDSA--IAPPPRPP--KPSQA 361
            G  L+ ++ V  TP+++ +     T   + +  +T +T G S+   A     P   PS+ 
Sbjct: 2867 GSTLLTSIPVSTTPVASSEASTLSTTPVDTSIPVTTSTEGSSSPTTAEGTSMPISTPSEV 2926

Query: 362  ETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGESAGR 421
             TP         P++ +  S  +T P     P   ++    +SS  T E       + G 
Sbjct: 2927 STPLTSILVSTVPVAGSEASTLSTTPVDTRTPVTTSAEA--SSSPTTAEGTSMPISTPGE 2984

Query: 422  SAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYIPMSP 481
                ++    S +P       + S    D   P+    +T      +   ++   IP+S 
Sbjct: 2985 RRTPLTSMSVSTMPVASSEASTLSRTPADTSTPV----TTSTEASSSPTTAEGTGIPIST 3040

Query: 482  GAHHFDSLGYPSTTLPVHRGP---SRGSEIQPPPVNRN----LKPDRKAKPTPLD----- 529
             +        P T++PV   P      S +   PV+ N       +  + PTP +     
Sbjct: 3041 PSEG----STPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVSSSPTPAEGTSMP 3096

Query: 530  ----LRNNTVIDELPFKS-PITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENY 584
                   +T +  +P  + P+T S   A  T +++      P++T +   +    SE   
Sbjct: 3097 ISTYSEGSTPLTGVPVSTTPVTSS---AISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTS 3153

Query: 585  VPMQNP------------------------VSASPVPSGTNSPAPKKSTGSVDYLALDFQ 620
            +P   P                        +SA+PV + T      ++T S         
Sbjct: 3154 MPTSTPSEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIP 3213

Query: 621  PSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEP 670
             S+PS    P TS   S+  V   +     T  + +     T    SS P
Sbjct: 3214 TSTPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSP 3263



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 87/396 (21%), Positives = 138/396 (34%), Gaps = 63/396 (15%)

Query: 278  TKGSLTGSETDNEDVYTFKTPSNTLCREFGDLLVDNMDVPATPLSAYQ--IPRTFTLDKN 335
            T    T S T         TPS       G   + ++ V  TP+++ +  I  T  +D N
Sbjct: 3197 TSTEATSSTTAEGTSIPTSTPSE------GMTPLTSVPVSNTPVASSEASILSTTPVDSN 3250

Query: 336  HNAMTVATPGDSAIAPPPRPP-------KPSQAETPRWGSPQQRPPISENSRSVAATIPR 388
                T  T    A + PP           PS+  TP    P     ++ +  S  +T P 
Sbjct: 3251 ----TPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPA 3306

Query: 389  RNTLPAMDNSRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNS 448
              + P    S+   +SS    +       +    +  +++   S  P       + ST  
Sbjct: 3307 DTSTPVTTYSQ--ASSSPPIADGTSMPTSTYSEGSTPLTNMSFSTTPVVSSEASTLSTTP 3364

Query: 449  EDNYVPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEI 508
             D   P+   +   L+   A   S    IP S  +        P  ++PV   P   SE+
Sbjct: 3365 VDTSTPVTTSTEASLSPTTAEGTS----IPTSSPSEGTT----PLASMPVSTTPVVSSEV 3416

Query: 509  ---QPPPVNRNLK-------------PDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRA 552
                  PV+ N                +  + PT      +T +  +P  +  T   S  
Sbjct: 3417 NTLSTTPVDSNTLVTTSTEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLST--TPVASSE 3474

Query: 553  NHTFNSSSSQYCRPISTQS----------ITSTDSGDSEENYVPMQN-PVSASPVPSGTN 601
              T +++      P++T S          +TS  +  + E   P+ N PVS +PV S   
Sbjct: 3475 ASTLSTTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVAS--- 3531

Query: 602  SPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTS 637
            S A   ST  VD  +  F  SS      P+T  VT+
Sbjct: 3532 SEASTLSTTPVD--SNTFVTSSSQASSSPATLQVTT 3565



 Score = 37.0 bits (84), Expect = 0.060
 Identities = 67/356 (18%), Positives = 115/356 (32%), Gaps = 35/356 (9%)

Query: 318  ATPLSAYQIPRTFTLDKNHNAMT---------VATPGDSAIAPPPRPPKPSQAETPRWGS 368
            +TPL++  + +T       + ++         + T  +++ +P           TP  GS
Sbjct: 746  STPLTSMPVSKTLLTSSEASTLSTTPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEGS 805

Query: 369  PQQRP-PISENSRSVAATIPRRNTL---PAMDNSRLHRASSCETYEYPQRGGESAGRSAE 424
            P     P+S        T P  +TL   P   NS +  ++   +   P  G      +  
Sbjct: 806  PLLTSIPVS----ITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTPAEGTSMPTSTYS 861

Query: 425  SMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYIPMS-PGA 483
                 + S      +V  S  +      V  +   +       +   S+   +P S PG 
Sbjct: 862  EGRTPLTSMPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPGE 921

Query: 484  HHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKS 543
                    P +T PV    +R     P   +  +    +A  +P      ++    P + 
Sbjct: 922  GSTPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPSEG 981

Query: 544  PITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSAS---PVPSGT 600
                + +  +HT  ++S       ST S T  DS        P+     AS   P   GT
Sbjct: 982  TTPLTSTPVSHTLVANSE-----ASTLSTTPVDSN------TPLTTSTEASSPPPTAEGT 1030

Query: 601  NSPAPKKSTGSVDYLALDFQP---SSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQA 653
            + P    S GS     +       +S       +T + TS     Y Q     T A
Sbjct: 1031 SMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTSTPVTTYSQASSSSTTA 1086



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 76/385 (19%), Positives = 144/385 (37%), Gaps = 37/385 (9%)

Query: 278  TKGSLTGSETDNEDVYTFKTPSNTLCREFGDLLVDNMDVPATPLSAYQIPRTFT--LDKN 335
            T    + S T  ED+     P +T     G  L+ ++ V  TP+++ +     T  +D N
Sbjct: 2489 TSTEASSSPTTAEDIVV---PISTASE--GSTLLTSIPVSTTPVASPEASTLSTTPVDSN 2543

Query: 336  HNAMT---VATPGDSAIAPPPRPPKPSQAETPRWGSPQQRPPISENSRSVAATIPRRNTL 392
               +T   +++   SA          S+  TP    P    P++ +  S  +T P   ++
Sbjct: 2544 SPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLRSMPVSTKPLASSEASTLSTTPVDTSI 2603

Query: 393  PAMDNSRLHRASSCETYEYPQRGGESAG--RSAESMSDGVGSFLPGKMIVGRSDSTNSED 450
            P          +S ET   P    +++    +   +S  + S L   M V  S+++    
Sbjct: 2604 PV--------TTSTETSSSPTTAKDTSMPISTPSEVSTSLTSILVSTMPVASSEASTLST 2655

Query: 451  NYVPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLG--YPSTTLPVHRGPSRGSEI 508
              V      +T      +   ++   +P S        L     STTL  +   S  S +
Sbjct: 2656 TPVDTRTLVTTSTGTSSSPTTAEGSSMPTSTPGERSTPLTNILVSTTLLAN---SEASTL 2712

Query: 509  QPPPVNRN----LKPDRKAKPTPLD---LRNNTVID-ELPFKSPITKSWSRAN---HTFN 557
               PV+ +       +  + PT  +   +R +T  D   P  S +  +   A+    T +
Sbjct: 2713 STTPVDTSTPVTTSAEASSSPTTAEGTSMRISTPSDGSTPLTSILVSTLPVASSEASTVS 2772

Query: 558  SSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSAS-PVPSGTNSPAPKKSTGSVDYLA 616
            +++     P++T +  S+    +E   +P   P   S P+ S   +  P  S+ +     
Sbjct: 2773 TTAVDTSIPVTTSTEASSSPTTAEVTSMPTSTPSETSTPLTSMPVNHTPVASSEAGTLST 2832

Query: 617  LDFQPSSPSPHRKPSTSSVTSDEKV 641
                 S+P      ++SS T+ E +
Sbjct: 2833 TPVDTSTPVTTSTKASSSPTTAEGI 2857


>gi|55741447 pleckstrin homology domain containing, family H (with
           MyTH4 domain) member 1 [Homo sapiens]
          Length = 1364

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 31/110 (28%), Positives = 56/110 (50%), Gaps = 21/110 (19%)

Query: 3   GGGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYK--NDHSKKPLRI 60
           GG  +  +G+L K   + K     WK+RWF+LR G+       + YYK  +D  +KP   
Sbjct: 575 GGESLEKSGYLLKMGSQVK----TWKRRWFVLRQGQ-------IMYYKSPSDVIRKPQGQ 623

Query: 61  INLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQ 110
           ++LN   Q+  G        + S  F + + ++T+YL A++   + +W++
Sbjct: 624 VDLNSRCQIVRG--------EGSQTFQLISEKKTYYLTADSPSLLEEWIR 665


>gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Homo
           sapiens]
          Length = 1034

 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 50/189 (26%), Positives = 73/189 (38%), Gaps = 38/189 (20%)

Query: 3   GGGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIIN 62
           G GD  C GWL K    K      WKK WF+L+          L +Y N+  +K    I+
Sbjct: 569 GRGD--CEGWLWKKKDAKSYFSQKWKKYWFVLKDAS-------LYWYINEEDEKAEGFIS 619

Query: 63  L-NFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQA 121
           L  F  ++D      KK    +    IK    +FY  AE  +DMN+W+  I         
Sbjct: 620 LPEF--KIDRASECRKKYAFKACHPKIK----SFYFAAEHLDDMNRWLNRI--------- 664

Query: 122 EESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHMQ 181
                   N+ +AG+  R    E     Q    E         S P   +  PP   + +
Sbjct: 665 --------NMLTAGYAER----ERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPR 712

Query: 182 -PTLSTSAP 189
            P++S ++P
Sbjct: 713 PPSMSCASP 721


>gi|197313732 pleckstrin homology-like domain, family B, member 2
            isoform a [Homo sapiens]
          Length = 1253

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 31/105 (29%), Positives = 45/105 (42%), Gaps = 10/105 (9%)

Query: 9    CTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQ 68
            C G+L K   + K     WKKRWF+    + +       YY + H  K   +I     E+
Sbjct: 1146 CRGFLIKMGGKIK----TWKKRWFVFDRNKRT-----FSYYADKHETKLKGVIYFQAIEE 1196

Query: 69   VDAGLTFN-KKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSI 112
            V      N  K       F +KT +R +Y+VA + E M  W+  I
Sbjct: 1197 VYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1241


>gi|197313730 pleckstrin homology-like domain, family B, member 2
            isoform a [Homo sapiens]
          Length = 1253

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 31/105 (29%), Positives = 45/105 (42%), Gaps = 10/105 (9%)

Query: 9    CTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQ 68
            C G+L K   + K     WKKRWF+    + +       YY + H  K   +I     E+
Sbjct: 1146 CRGFLIKMGGKIK----TWKKRWFVFDRNKRT-----FSYYADKHETKLKGVIYFQAIEE 1196

Query: 69   VDAGLTFN-KKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSI 112
            V      N  K       F +KT +R +Y+VA + E M  W+  I
Sbjct: 1197 VYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1241


>gi|197313728 pleckstrin homology-like domain, family B, member 2
            isoform b [Homo sapiens]
          Length = 1237

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 31/105 (29%), Positives = 45/105 (42%), Gaps = 10/105 (9%)

Query: 9    CTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQ 68
            C G+L K   + K     WKKRWF+    + +       YY + H  K   +I     E+
Sbjct: 1130 CRGFLIKMGGKIK----TWKKRWFVFDRNKRT-----FSYYADKHETKLKGVIYFQAIEE 1180

Query: 69   VDAGLTFN-KKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSI 112
            V      N  K       F +KT +R +Y+VA + E M  W+  I
Sbjct: 1181 VYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1225


>gi|21955172 pleckstrin homology-like domain, family B, member 2
            isoform c [Homo sapiens]
          Length = 1210

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 31/105 (29%), Positives = 45/105 (42%), Gaps = 10/105 (9%)

Query: 9    CTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQ 68
            C G+L K   + K     WKKRWF+    + +       YY + H  K   +I     E+
Sbjct: 1103 CRGFLIKMGGKIK----TWKKRWFVFDRNKRT-----FSYYADKHETKLKGVIYFQAIEE 1153

Query: 69   VDAGLTFN-KKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSI 112
            V      N  K       F +KT +R +Y+VA + E M  W+  I
Sbjct: 1154 VYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVI 1198


>gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1
           [Homo sapiens]
          Length = 438

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 61/269 (22%), Positives = 101/269 (37%), Gaps = 28/269 (10%)

Query: 5   GDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINL- 63
           G   C GWL K   +       WKK W IL+          L +Y N  ++K    +NL 
Sbjct: 41  GHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS-------LYWYSNQMAEKADGFVNLP 93

Query: 64  NFCEQVDAGLTFNKKELQDSFVFDIKTSE-RTFYLVAETEEDMNKWVQSICQICGFNQAE 122
           +F  +          E +    F I   + +TFY  AE  ++MN W+  +      +Q  
Sbjct: 94  DFTVE-------RASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAV-IHQES 145

Query: 123 ESTDSLRNVSSAGHGPR---SSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNH 179
            + D      S    P     +P    +S    L  +++S+ S S   T ++F    +  
Sbjct: 146 TTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTV 205

Query: 180 MQP-TLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCV 238
             P +  +S  +E   L   +     N+ SA+  +G   +F ++  + V   A  +    
Sbjct: 206 KTPSSFPSSLSKERQSLPDTV-----NSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALE 260

Query: 239 NGISGQVHGFYSLPKPSRHNTEFRDSTYD 267
           N       GF  L   S  +T    S +D
Sbjct: 261 NSFVTSESGF--LNSLSSDDTSSLSSNHD 287


>gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1
           [Homo sapiens]
          Length = 438

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 61/269 (22%), Positives = 101/269 (37%), Gaps = 28/269 (10%)

Query: 5   GDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINL- 63
           G   C GWL K   +       WKK W IL+          L +Y N  ++K    +NL 
Sbjct: 41  GHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS-------LYWYSNQMAEKADGFVNLP 93

Query: 64  NFCEQVDAGLTFNKKELQDSFVFDIKTSE-RTFYLVAETEEDMNKWVQSICQICGFNQAE 122
           +F  +          E +    F I   + +TFY  AE  ++MN W+  +      +Q  
Sbjct: 94  DFTVE-------RASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAV-IHQES 145

Query: 123 ESTDSLRNVSSAGHGPR---SSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNH 179
            + D      S    P     +P    +S    L  +++S+ S S   T ++F    +  
Sbjct: 146 TTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTV 205

Query: 180 MQP-TLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCV 238
             P +  +S  +E   L   +     N+ SA+  +G   +F ++  + V   A  +    
Sbjct: 206 KTPSSFPSSLSKERQSLPDTV-----NSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALE 260

Query: 239 NGISGQVHGFYSLPKPSRHNTEFRDSTYD 267
           N       GF  L   S  +T    S +D
Sbjct: 261 NSFVTSESGF--LNSLSSDDTSSLSSNHD 287


>gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [Homo
           sapiens]
          Length = 437

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 61/269 (22%), Positives = 101/269 (37%), Gaps = 28/269 (10%)

Query: 5   GDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINL- 63
           G   C GWL K   +       WKK W IL+          L +Y N  ++K    +NL 
Sbjct: 40  GHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS-------LYWYSNQMAEKADGFVNLP 92

Query: 64  NFCEQVDAGLTFNKKELQDSFVFDIKTSE-RTFYLVAETEEDMNKWVQSICQICGFNQAE 122
           +F  +          E +    F I   + +TFY  AE  ++MN W+  +      +Q  
Sbjct: 93  DFTVE-------RASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAV-IHQES 144

Query: 123 ESTDSLRNVSSAGHGPR---SSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNH 179
            + D      S    P     +P    +S    L  +++S+ S S   T ++F    +  
Sbjct: 145 TTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTV 204

Query: 180 MQP-TLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCV 238
             P +  +S  +E   L   +     N+ SA+  +G   +F ++  + V   A  +    
Sbjct: 205 KTPSSFPSSLSKERQSLPDTV-----NSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALE 259

Query: 239 NGISGQVHGFYSLPKPSRHNTEFRDSTYD 267
           N       GF  L   S  +T    S +D
Sbjct: 260 NSFVTSESGF--LNSLSSDDTSSLSSNHD 286


>gi|24432056 hypothetical protein LOC144717 [Homo sapiens]
          Length = 249

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 27/93 (29%), Positives = 49/93 (52%), Gaps = 17/93 (18%)

Query: 23  RRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQD 82
           R  A+ +RWF+LR        ++L Y+++  S++P+ +I L  C       T    E  +
Sbjct: 30  RHAAYHRRWFVLRG-------NMLFYFEDAASREPVGVIILEGC-------TVELVEAAE 75

Query: 83  SFVFDIK---TSERTFYLVAETEEDMNKWVQSI 112
            F F ++   T  RT+ L AE+++ M  WV+++
Sbjct: 76  EFAFAVRFAGTRARTYVLAAESQDAMEGWVKAL 108


>gi|46391075 hypothetical protein LOC79949 [Homo sapiens]
          Length = 363

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 46/154 (29%), Positives = 69/154 (44%), Gaps = 25/154 (16%)

Query: 15  KSPPEKKLRRY-AWKKRWFIL-RSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAG 72
           KSPP +      +WKKR+FIL ++G  S     L YYK+ H +  + I   +    V+ G
Sbjct: 29  KSPPSQLFSSVTSWKKRFFILSKAGEKSFS---LSYYKDHHHRGSIEIDQNS---SVEVG 82

Query: 73  LTFNKK--ELQDSF------VFDIKTSERTFYLVAETEEDMNKWVQSIC----QICGFNQ 120
           ++  +K   +Q  F      V  I+T+ R ++L+    E +  WV  +      I    Q
Sbjct: 83  ISSQEKMQSVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQ 142

Query: 121 AEESTDSLRN-----VSSAGHGPRSSPAELSSSS 149
             E   SL N      SS   GP S+   + SSS
Sbjct: 143 NTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSS 176


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.126    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,035,569
Number of Sequences: 37866
Number of extensions: 1691164
Number of successful extensions: 9815
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 356
Number of HSP's that attempted gapping in prelim test: 8629
Number of HSP's gapped (non-prelim): 1348
length of query: 676
length of database: 18,247,518
effective HSP length: 109
effective length of query: 567
effective length of database: 14,120,124
effective search space: 8006110308
effective search space used: 8006110308
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.