Guide to the Human Genome
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Search of human proteins with 17978491

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|17978491 CD97 antigen isoform 1 precursor [Homo sapiens]
         (835 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|17978491 CD97 antigen isoform 1 precursor [Homo sapiens]          1745   0.0  
gi|17978489 CD97 antigen isoform 2 precursor [Homo sapiens]          1410   0.0  
gi|68508955 CD97 antigen isoform 3 precursor [Homo sapiens]          1371   0.0  
gi|23397681 egf-like module containing, mucin-like, hormone rece...  1056   0.0  
gi|23397689 egf-like module containing, mucin-like, hormone rece...  1037   0.0  
gi|23397685 egf-like module containing, mucin-like, hormone rece...   728   0.0  
gi|23397693 egf-like module containing, mucin-like, hormone rece...   708   0.0  
gi|23397683 egf-like module containing, mucin-like, hormone rece...   692   0.0  
gi|23397691 egf-like module containing, mucin-like, hormone rece...   673   0.0  
gi|23397687 egf-like module containing, mucin-like, hormone rece...   550   e-156
gi|40807489 egf-like module containing, mucin-like, hormone rece...   437   e-122
gi|133930786 egf-like module-containing mucin-like receptor 3 [H...   311   1e-84
gi|6912464 latrophilin 2 precursor [Homo sapiens]                     294   2e-79
gi|57165355 latrophilin 1 isoform 1 precursor [Homo sapiens]          291   1e-78
gi|41281557 latrophilin 1 isoform 2 precursor [Homo sapiens]          291   1e-78
gi|148806925 EGF, latrophilin and seven transmembrane domain con...   291   1e-78
gi|163792198 latrophilin 3 precursor [Homo sapiens]                   280   3e-75
gi|45433552 G protein-coupled receptor 133 [Homo sapiens]             191   2e-48
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s...   189   7e-48
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ...   166   8e-41
gi|223556012 G-protein coupled receptor 113 isoform 1 [Homo sapi...   159   1e-38
gi|223556014 G-protein coupled receptor 113 isoform 2 [Homo sapi...   159   1e-38
gi|141802362 G-protein coupled receptor 113 isoform 3 [Homo sapi...   159   1e-38
gi|24430141 fibrillin 1 precursor [Homo sapiens]                      158   2e-38
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo...   158   2e-38
gi|119943125 G protein-coupled receptor 64 isoform 3 [Homo sapiens]   154   2e-37
gi|119943116 G protein-coupled receptor 64 isoform 2 [Homo sapiens]   154   2e-37
gi|119943120 G protein-coupled receptor 64 isoform 1 [Homo sapiens]   154   2e-37
gi|119943129 G protein-coupled receptor 64 isoform 4 [Homo sapiens]   154   2e-37
gi|56237021 fibrillin 3 precursor [Homo sapiens]                      153   6e-37

>gi|17978491 CD97 antigen isoform 1 precursor [Homo sapiens]
          Length = 835

 Score = 1745 bits (4519), Expect = 0.0
 Identities = 835/835 (100%), Positives = 835/835 (100%)

Query: 1   MGGRVFLAFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTE 60
           MGGRVFLAFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTE
Sbjct: 1   MGGRVFLAFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTE 60

Query: 61  TCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDEC 120
           TCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDEC
Sbjct: 61  TCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDEC 120

Query: 121 QQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNN 180
           QQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNN
Sbjct: 121 QQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNN 180

Query: 181 VGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPG 240
           VGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPG
Sbjct: 181 VGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPG 240

Query: 241 WKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVTIQN 300
           WKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVTIQN
Sbjct: 241 WKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVTIQN 300

Query: 301 VIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTEL 360
           VIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTEL
Sbjct: 301 VIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTEL 360

Query: 361 TLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLNLHS 420
           TLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLNLHS
Sbjct: 361 TLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLNLHS 420

Query: 421 KKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDP 480
           KKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDP
Sbjct: 421 KKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDP 480

Query: 481 PAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHY 540
           PAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHY
Sbjct: 481 PAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHY 540

Query: 541 DVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGSTIFLAG 600
           DVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGSTIFLAG
Sbjct: 541 DVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGSTIFLAG 600

Query: 601 IENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWLCLIGY 660
           IENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWLCLIGY
Sbjct: 601 IENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWLCLIGY 660

Query: 661 GVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQ 720
           GVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQ
Sbjct: 661 GVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQ 720

Query: 721 KFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGA 780
           KFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGA
Sbjct: 721 KFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGA 780

Query: 781 FLYLLHCLLNKKVREEYRKWACLVAGGSKYSEFTSTTSGTGHNQTRALRASESGI 835
           FLYLLHCLLNKKVREEYRKWACLVAGGSKYSEFTSTTSGTGHNQTRALRASESGI
Sbjct: 781 FLYLLHCLLNKKVREEYRKWACLVAGGSKYSEFTSTTSGTGHNQTRALRASESGI 835


>gi|17978489 CD97 antigen isoform 2 precursor [Homo sapiens]
          Length = 742

 Score = 1410 bits (3650), Expect = 0.0
 Identities = 712/835 (85%), Positives = 720/835 (86%), Gaps = 93/835 (11%)

Query: 1   MGGRVFLAFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTE 60
           MGGRVFLAFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTE
Sbjct: 1   MGGRVFLAFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTE 60

Query: 61  TCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDEC 120
           TCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDEC
Sbjct: 61  TCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDEC 120

Query: 121 QQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNN 180
                 C S   C NT+GSY+C+C PG+K                               
Sbjct: 121 SSGQHQCDSSTVCFNTVGSYSCRCRPGWK------------------------------- 149

Query: 181 VGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPG 240
                        P  G PN   +TVCED               + F+T           
Sbjct: 150 -------------PRHGIPNNQKDTVCED---------------MTFST----------- 170

Query: 241 WKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVTIQN 300
           W P  G+                       HSQTLSRFFDKVQDLGRDSKTSSAEVTIQN
Sbjct: 171 WTPPPGV-----------------------HSQTLSRFFDKVQDLGRDSKTSSAEVTIQN 207

Query: 301 VIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTEL 360
           VIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTEL
Sbjct: 208 VIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTEL 267

Query: 361 TLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLNLHS 420
           TLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLNLHS
Sbjct: 268 TLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLNLHS 327

Query: 421 KKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDP 480
           KKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDP
Sbjct: 328 KKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDP 387

Query: 481 PAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHY 540
           PAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHY
Sbjct: 388 PAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHY 447

Query: 541 DVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGSTIFLAG 600
           DVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGSTIFLAG
Sbjct: 448 DVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGSTIFLAG 507

Query: 601 IENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWLCLIGY 660
           IENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWLCLIGY
Sbjct: 508 IENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWLCLIGY 567

Query: 661 GVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQ 720
           GVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQ
Sbjct: 568 GVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQ 627

Query: 721 KFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGA 780
           KFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGA
Sbjct: 628 KFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGA 687

Query: 781 FLYLLHCLLNKKVREEYRKWACLVAGGSKYSEFTSTTSGTGHNQTRALRASESGI 835
           FLYLLHCLLNKKVREEYRKWACLVAGGSKYSEFTSTTSGTGHNQTRALRASESGI
Sbjct: 688 FLYLLHCLLNKKVREEYRKWACLVAGGSKYSEFTSTTSGTGHNQTRALRASESGI 742


>gi|68508955 CD97 antigen isoform 3 precursor [Homo sapiens]
          Length = 786

 Score = 1371 bits (3549), Expect = 0.0
 Identities = 696/843 (82%), Positives = 712/843 (84%), Gaps = 65/843 (7%)

Query: 1   MGGRVFLAFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTE 60
           MGGRVFLAFCVWLTL                                          P  
Sbjct: 1   MGGRVFLAFCVWLTL------------------------------------------PGA 18

Query: 61  TCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDEC 120
              D   CA      C + S C N      C C+PG+   S   T   E   TC D++EC
Sbjct: 19  ETQDSRGCAR----WCPQNSSCVNATA---CRCNPGFSSFSEIITTPTE---TCDDINEC 68

Query: 121 QQNPRL-CKSYGTCVNTLGSYTCQCLPGFK-------FIPEDPKVCTDVNECTSGQNPCH 172
               ++ C  +  C NT GSY C C PG++       F  E    C DV+EC      C 
Sbjct: 69  ATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCK 128

Query: 173 SSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGS 232
           S   C+N +GSY C+C PG++ IP  P      VC DVDECSSGQHQCDSSTVCFNTVGS
Sbjct: 129 SYGTCVNTLGSYTCQCLPGFKFIPEDPK-----VCTDVDECSSGQHQCDSSTVCFNTVGS 183

Query: 233 YSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTS 292
           YSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTS
Sbjct: 184 YSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTS 243

Query: 293 SAEVTIQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTY 352
           SAEVTIQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTY
Sbjct: 244 SAEVTIQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTY 303

Query: 353 ISPSNTELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLA 412
           ISPSNTELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLA
Sbjct: 304 ISPSNTELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLA 363

Query: 413 NASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESS 472
           NASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESS
Sbjct: 364 NASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESS 423

Query: 473 DGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSS 532
           DGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSS
Sbjct: 424 DGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSS 483

Query: 533 FAILMAHYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFV 592
           FAILMAHYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFV
Sbjct: 484 FAILMAHYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFV 543

Query: 593 GSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLST 652
           GSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLST
Sbjct: 544 GSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLST 603

Query: 653 RWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFV 712
           RWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFV
Sbjct: 604 RWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFV 663

Query: 713 TTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFT 772
           TTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFT
Sbjct: 664 TTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFT 723

Query: 773 ILNCLQGAFLYLLHCLLNKKVREEYRKWACLVAGGSKYSEFTSTTSGTGHNQTRALRASE 832
           ILNCLQGAFLYLLHCLLNKKVREEYRKWACLVAGGSKYSEFTSTTSGTGHNQTRALRASE
Sbjct: 724 ILNCLQGAFLYLLHCLLNKKVREEYRKWACLVAGGSKYSEFTSTTSGTGHNQTRALRASE 783

Query: 833 SGI 835
           SGI
Sbjct: 784 SGI 786


>gi|23397681 egf-like module containing, mucin-like, hormone
           receptor-like sequence 2 isoform a [Homo sapiens]
          Length = 823

 Score = 1056 bits (2731), Expect = 0.0
 Identities = 508/811 (62%), Positives = 610/811 (75%), Gaps = 28/811 (3%)

Query: 1   MGGRVFL---AFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITT 57
           MGGRVFL   AFCVWLTLPGAETQDSRGCARWCPQ+SSCVNATACRCNPGFSSFSEIITT
Sbjct: 1   MGGRVFLVFLAFCVWLTLPGAETQDSRGCARWCPQDSSCVNATACRCNPGFSSFSEIITT 60

Query: 58  PTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDV 117
           P ETCDDINECAT SKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDV
Sbjct: 61  PMETCDDINECATLSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDV 120

Query: 118 DECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHC 177
           DECQQNPRLCKSYGTCVNTLGSYTCQCLPGFK  PEDPK+CTDVNECTSGQNPCHSSTHC
Sbjct: 121 DECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKLKPEDPKLCTDVNECTSGQNPCHSSTHC 180

Query: 178 LNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRC 237
           LNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRC
Sbjct: 181 LNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRC 240

Query: 238 RPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVT 297
           RPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRD K   A  T
Sbjct: 241 RPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDYKPGLANNT 300

Query: 298 IQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSN 357
           IQ++++ +DEL+EAPGD+E L    +H +A+ LL  LED++R L+K+L  G   +  P+ 
Sbjct: 301 IQSILQALDELLEAPGDLETLPRLQQHCVASHLLDGLEDVLRGLSKNLSNGLLNFSYPAG 360

Query: 358 TELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLN 417
           TEL+L +Q++ D++VT+ Q+ A M+L+W  A  + DPGP+V G++SI  M  LLA A L 
Sbjct: 361 TELSLEVQKQVDRSVTLRQNQAVMQLDWNQAQKSGDPGPSVVGLVSIPGMGKLLAEAPLV 420

Query: 418 LHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAG 477
           L  +KQ  L E ++  ++      LS V S FLS+N+T+ L+SP+ F FSH         
Sbjct: 421 LEPEKQMLLHETHQGLLQDGSPILLSDVISAFLSNNDTQNLSSPVTFTFSH--------- 471

Query: 478 RDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILM 537
                + V+  PRQ++LC FW+   +  GHWAT GC  +G+++ ST C+C+HLSSFA+LM
Sbjct: 472 -----RSVI--PRQKVLCVFWEHGQNGCGHWATTGCSTIGTRDTSTICRCTHLSSFAVLM 524

Query: 538 AHYDV--EDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGST 595
           AHYDV  ED  LT+IT +GL++SL CLLL  LTFLL + IQ + T++HL L +CLF+   
Sbjct: 525 AHYDVQEEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQLSLCLFLAHL 584

Query: 596 IFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELY-----FLVVRVFQGQGL 650
           +FL  I+  G +V   C ++AG LHY +LA   WM LE L L+       VV        
Sbjct: 585 LFLVAIDQTGHKV--LCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLTVVNYSSINRF 642

Query: 651 STRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVI 710
             + +  +GYGVP + V +SAA     YG P  CWL  E+GF+W FLGPV  I   N V+
Sbjct: 643 MKKLMFPVGYGVPAVTVAISAASRPHLYGTPSRCWLQPEKGFIWGFLGPVCAIFSVNLVL 702

Query: 711 FVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYV 770
           F+ T+W L  + S +N ++  L+  R L   A AQLF+LGCTW  G+      + V+ Y+
Sbjct: 703 FLVTLWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFILGCTWCLGILQVGPAARVMAYL 762

Query: 771 FTILNCLQGAFLYLLHCLLNKKVREEYRKWA 801
           FTI+N LQG F++L++CLL+++VRE+Y KW+
Sbjct: 763 FTIINSLQGVFIFLVYCLLSQQVREQYGKWS 793


>gi|23397689 egf-like module containing, mucin-like, hormone
           receptor-like sequence 2 isoform e [Homo sapiens]
          Length = 812

 Score = 1037 bits (2681), Expect = 0.0
 Identities = 503/811 (62%), Positives = 602/811 (74%), Gaps = 39/811 (4%)

Query: 1   MGGRVFL---AFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITT 57
           MGGRVFL   AFCVWLTLPGAETQDSRGCARWCPQ+SSCVNATACRCNPGFSSFSEIITT
Sbjct: 1   MGGRVFLVFLAFCVWLTLPGAETQDSRGCARWCPQDSSCVNATACRCNPGFSSFSEIITT 60

Query: 58  PTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDV 117
           P ETCDDINECAT SKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDV
Sbjct: 61  PMETCDDINECATLSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDV 120

Query: 118 DECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHC 177
           DECQQNPRLCKSYGTCVNTLGSYTCQCLPGFK  PEDPK+CTDVNECTSGQNPCHSSTHC
Sbjct: 121 DECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKLKPEDPKLCTDVNECTSGQNPCHSSTHC 180

Query: 178 LNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRC 237
           LNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRC
Sbjct: 181 LNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRC 240

Query: 238 RPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVT 297
           RPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRD K   A  T
Sbjct: 241 RPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDYKPGLANNT 300

Query: 298 IQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSN 357
           IQ++++ +DEL+EAPGD+E L    +H +A+ LL  LED++R L+K+L  G   +  P+ 
Sbjct: 301 IQSILQALDELLEAPGDLETLPRLQQHCVASHLLDGLEDVLRGLSKNLSNGLLNFSYPAG 360

Query: 358 TELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLN 417
           TEL+L +Q++ D++VT+ Q+ A M+L+W  A  + DPG           M  LLA A L 
Sbjct: 361 TELSLEVQKQVDRSVTLRQNQAVMQLDWNQAQKSGDPG-----------MGKLLAEAPLV 409

Query: 418 LHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAG 477
           L  +KQ  L E ++  ++      LS V S FLS+N+T+ L+SP+ F FSH         
Sbjct: 410 LEPEKQMLLHETHQGLLQDGSPILLSDVISAFLSNNDTQNLSSPVTFTFSH--------- 460

Query: 478 RDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILM 537
                + V+  PRQ++LC FW+   +  GHWAT GC  +G+++ ST C+C+HLSSFA+LM
Sbjct: 461 -----RSVI--PRQKVLCVFWEHGQNGCGHWATTGCSTIGTRDTSTICRCTHLSSFAVLM 513

Query: 538 AHYDV--EDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGST 595
           AHYDV  ED  LT+IT +GL++SL CLLL  LTFLL + IQ + T++HL L +CLF+   
Sbjct: 514 AHYDVQEEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQLSLCLFLAHL 573

Query: 596 IFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELY-----FLVVRVFQGQGL 650
           +FL  I+  G +V   C ++AG LHY +LA   WM LE L L+       VV        
Sbjct: 574 LFLVAIDQTGHKV--LCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLTVVNYSSINRF 631

Query: 651 STRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVI 710
             + +  +GYGVP + V +SAA     YG P  CWL  E+GF+W FLGPV  I   N V+
Sbjct: 632 MKKLMFPVGYGVPAVTVAISAASRPHLYGTPSRCWLQPEKGFIWGFLGPVCAIFSVNLVL 691

Query: 711 FVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYV 770
           F+ T+W L  + S +N ++  L+  R L   A AQLF+LGCTW  G+      + V+ Y+
Sbjct: 692 FLVTLWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFILGCTWCLGILQVGPAARVMAYL 751

Query: 771 FTILNCLQGAFLYLLHCLLNKKVREEYRKWA 801
           FTI+N LQG F++L++CLL+++VRE+Y KW+
Sbjct: 752 FTIINSLQGVFIFLVYCLLSQQVREQYGKWS 782


>gi|23397685 egf-like module containing, mucin-like, hormone
           receptor-like sequence 2 isoform c [Homo sapiens]
          Length = 730

 Score =  728 bits (1878), Expect = 0.0
 Identities = 388/811 (47%), Positives = 497/811 (61%), Gaps = 121/811 (14%)

Query: 1   MGGRVFL---AFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITT 57
           MGGRVFL   AFCVWLTLPGAETQDSRGCARWCPQ+SSCVNATACRCNPGFSSFSEIITT
Sbjct: 1   MGGRVFLVFLAFCVWLTLPGAETQDSRGCARWCPQDSSCVNATACRCNPGFSSFSEIITT 60

Query: 58  PTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDV 117
           P ETCDDINECAT SKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDV
Sbjct: 61  PMETCDDINECATLSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDV 120

Query: 118 DECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHC 177
           DEC      C S   C NT+GSY+C+C PG+K                            
Sbjct: 121 DECSSGQHQCDSSTVCFNTVGSYSCRCRPGWK---------------------------- 152

Query: 178 LNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRC 237
                           P  G PN   +TVCED               + F+T        
Sbjct: 153 ----------------PRHGIPNNQKDTVCED---------------MTFST-------- 173

Query: 238 RPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVT 297
              W P  G+                       HSQTLSRFFDKVQDLGRD K   A  T
Sbjct: 174 ---WTPPPGV-----------------------HSQTLSRFFDKVQDLGRDYKPGLANNT 207

Query: 298 IQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSN 357
           IQ++++ +DEL+EAPGD+E L    +H +A+ LL  LED++R L+K+L  G   +  P+ 
Sbjct: 208 IQSILQALDELLEAPGDLETLPRLQQHCVASHLLDGLEDVLRGLSKNLSNGLLNFSYPAG 267

Query: 358 TELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLN 417
           TEL+L +Q++ D++VT+ Q+ A M+L+W  A  + DPGP+V G++SI  M  LLA A L 
Sbjct: 268 TELSLEVQKQVDRSVTLRQNQAVMQLDWNQAQKSGDPGPSVVGLVSIPGMGKLLAEAPLV 327

Query: 418 LHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAG 477
           L  +KQ  L E ++  ++      LS V S FLS+N+T+ L+SP+ F FSH         
Sbjct: 328 LEPEKQMLLHETHQGLLQDGSPILLSDVISAFLSNNDTQNLSSPVTFTFSH--------- 378

Query: 478 RDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILM 537
                + V+  PRQ++LC FW+   +  GHWAT GC  +G+++ ST C+C+HLSSFA+LM
Sbjct: 379 -----RSVI--PRQKVLCVFWEHGQNGCGHWATTGCSTIGTRDTSTICRCTHLSSFAVLM 431

Query: 538 AHYDV--EDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGST 595
           AHYDV  ED  LT+IT +GL++SL CLLL  LTFLL + IQ + T++HL L +CLF+   
Sbjct: 432 AHYDVQEEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQLSLCLFLAHL 491

Query: 596 IFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELY-----FLVVRVFQGQGL 650
           +FL  I+  G +V   C ++AG LHY +LA   WM LE L L+       VV        
Sbjct: 492 LFLVAIDQTGHKV--LCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLTVVNYSSINRF 549

Query: 651 STRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVI 710
             + +  +GYGVP + V +SAA     YG P  CWL  E+GF+W FLGPV  I   N V+
Sbjct: 550 MKKLMFPVGYGVPAVTVAISAASRPHLYGTPSRCWLQPEKGFIWGFLGPVCAIFSVNLVL 609

Query: 711 FVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYV 770
           F+ T+W L  + S +N ++  L+  R L   A AQLF+LGCTW  G+      + V+ Y+
Sbjct: 610 FLVTLWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFILGCTWCLGILQVGPAARVMAYL 669

Query: 771 FTILNCLQGAFLYLLHCLLNKKVREEYRKWA 801
           FTI+N LQG F++L++CLL+++VRE+Y KW+
Sbjct: 670 FTIINSLQGVFIFLVYCLLSQQVREQYGKWS 700


>gi|23397693 egf-like module containing, mucin-like, hormone
           receptor-like sequence 2 isoform g [Homo sapiens]
          Length = 719

 Score =  708 bits (1828), Expect = 0.0
 Identities = 383/811 (47%), Positives = 489/811 (60%), Gaps = 132/811 (16%)

Query: 1   MGGRVFL---AFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITT 57
           MGGRVFL   AFCVWLTLPGAETQDSRGCARWCPQ+SSCVNATACRCNPGFSSFSEIITT
Sbjct: 1   MGGRVFLVFLAFCVWLTLPGAETQDSRGCARWCPQDSSCVNATACRCNPGFSSFSEIITT 60

Query: 58  PTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDV 117
           P ETCDDINECAT SKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDV
Sbjct: 61  PMETCDDINECATLSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDV 120

Query: 118 DECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHC 177
           DEC      C S   C NT+GSY+C+C PG+K                            
Sbjct: 121 DECSSGQHQCDSSTVCFNTVGSYSCRCRPGWK---------------------------- 152

Query: 178 LNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRC 237
                           P  G PN   +TVCED               + F+T        
Sbjct: 153 ----------------PRHGIPNNQKDTVCED---------------MTFST-------- 173

Query: 238 RPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVT 297
              W P  G+                       HSQTLSRFFDKVQDLGRD K   A  T
Sbjct: 174 ---WTPPPGV-----------------------HSQTLSRFFDKVQDLGRDYKPGLANNT 207

Query: 298 IQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSN 357
           IQ++++ +DEL+EAPGD+E L    +H +A+ LL  LED++R L+K+L  G   +  P+ 
Sbjct: 208 IQSILQALDELLEAPGDLETLPRLQQHCVASHLLDGLEDVLRGLSKNLSNGLLNFSYPAG 267

Query: 358 TELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLN 417
           TEL+L +Q++ D++VT+ Q+ A M+L+W  A  + DPG           M  LLA A L 
Sbjct: 268 TELSLEVQKQVDRSVTLRQNQAVMQLDWNQAQKSGDPG-----------MGKLLAEAPLV 316

Query: 418 LHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAG 477
           L  +KQ  L E ++  ++      LS V S FLS+N+T+ L+SP+ F FSH         
Sbjct: 317 LEPEKQMLLHETHQGLLQDGSPILLSDVISAFLSNNDTQNLSSPVTFTFSH--------- 367

Query: 478 RDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILM 537
                + V+  PRQ++LC FW+   +  GHWAT GC  +G+++ ST C+C+HLSSFA+LM
Sbjct: 368 -----RSVI--PRQKVLCVFWEHGQNGCGHWATTGCSTIGTRDTSTICRCTHLSSFAVLM 420

Query: 538 AHYDV--EDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGST 595
           AHYDV  ED  LT+IT +GL++SL CLLL  LTFLL + IQ + T++HL L +CLF+   
Sbjct: 421 AHYDVQEEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQLSLCLFLAHL 480

Query: 596 IFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELY-----FLVVRVFQGQGL 650
           +FL  I+  G +V   C ++AG LHY +LA   WM LE L L+       VV        
Sbjct: 481 LFLVAIDQTGHKV--LCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLTVVNYSSINRF 538

Query: 651 STRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVI 710
             + +  +GYGVP + V +SAA     YG P  CWL  E+GF+W FLGPV  I   N V+
Sbjct: 539 MKKLMFPVGYGVPAVTVAISAASRPHLYGTPSRCWLQPEKGFIWGFLGPVCAIFSVNLVL 598

Query: 711 FVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYV 770
           F+ T+W L  + S +N ++  L+  R L   A AQLF+LGCTW  G+      + V+ Y+
Sbjct: 599 FLVTLWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFILGCTWCLGILQVGPAARVMAYL 658

Query: 771 FTILNCLQGAFLYLLHCLLNKKVREEYRKWA 801
           FTI+N LQG F++L++CLL+++VRE+Y KW+
Sbjct: 659 FTIINSLQGVFIFLVYCLLSQQVREQYGKWS 689


>gi|23397683 egf-like module containing, mucin-like, hormone
           receptor-like sequence 2 isoform b [Homo sapiens]
          Length = 774

 Score =  692 bits (1786), Expect = 0.0
 Identities = 373/819 (45%), Positives = 490/819 (59%), Gaps = 93/819 (11%)

Query: 1   MGGRVFL---AFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITT 57
           MGGRVFL   AFCVWLTL                                          
Sbjct: 1   MGGRVFLVFLAFCVWLTL------------------------------------------ 18

Query: 58  PTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDV 117
           P     D   CA      C + S C N      C C+PG+   S   T   E   TC D+
Sbjct: 19  PGAETQDSRGCAR----WCPQDSSCVNATA---CRCNPGFSSFSEIITTPME---TCDDI 68

Query: 118 DECQQNPRL-CKSYGTCVNTLGSYTCQCLPGFK-------FIPEDPKVCTDVNECTSGQN 169
           +EC    ++ C  +  C NT GSY C C PG++       F  E    C DV+EC     
Sbjct: 69  NECATLSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPR 128

Query: 170 PCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNT 229
            C S   C+N +GSY C+C PG++  P  P      +C DVDECSSGQHQCDSSTVCFNT
Sbjct: 129 LCKSYGTCVNTLGSYTCQCLPGFKLKPEDPK-----LCTDVDECSSGQHQCDSSTVCFNT 183

Query: 230 VGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDS 289
           VGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRD 
Sbjct: 184 VGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDY 243

Query: 290 KTSSAEVTIQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGP 349
           K   A  TIQ++++ +DEL+EAPGD+E L    +H +A+ LL  LED++R L+K+L  G 
Sbjct: 244 KPGLANNTIQSILQALDELLEAPGDLETLPRLQQHCVASHLLDGLEDVLRGLSKNLSNGL 303

Query: 350 FTYISPSNTELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTT 409
             +  P+ TEL+L +Q++ D++VT+ Q+ A M+L+W  A  + DPGP+V G++SI  M  
Sbjct: 304 LNFSYPAGTELSLEVQKQVDRSVTLRQNQAVMQLDWNQAQKSGDPGPSVVGLVSIPGMGK 363

Query: 410 LLANASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHL 469
           LLA A L L  +KQ  L E ++  ++      LS V S FLS+N+T+ L+SP+ F FSH 
Sbjct: 364 LLAEAPLVLEPEKQMLLHETHQGLLQDGSPILLSDVISAFLSNNDTQNLSSPVTFTFSH- 422

Query: 470 ESSDGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSH 529
                        + V+  PRQ++LC FW+   +  GHWAT GC  +G+++ ST C+C+H
Sbjct: 423 -------------RSVI--PRQKVLCVFWEHGQNGCGHWATTGCSTIGTRDTSTICRCTH 467

Query: 530 LSSFAILMAHYDV--EDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLC 587
           LSSFA+LMAHYDV  ED  LT+IT +GL++SL CLLL  LTFLL + IQ + T++HL L 
Sbjct: 468 LSSFAVLMAHYDVQEEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQLS 527

Query: 588 ICLFVGSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELY-----FLVV 642
           +CLF+   +FL  I+  G +V   C ++AG LHY +LA   WM LE L L+       VV
Sbjct: 528 LCLFLAHLLFLVAIDQTGHKV--LCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLTVV 585

Query: 643 RVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTF 702
                     + +  +GYGVP + V +SAA     YG P  CWL  E+GF+W FLGPV  
Sbjct: 586 NYSSINRFMKKLMFPVGYGVPAVTVAISAASRPHLYGTPSRCWLQPEKGFIWGFLGPVCA 645

Query: 703 IILCNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDD 762
           I   N V+F+ T+W L  + S +N ++  L+  R L   A AQLF+LGCTW  G+     
Sbjct: 646 IFSVNLVLFLVTLWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFILGCTWCLGILQVGP 705

Query: 763 RSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWA 801
            + V+ Y+FTI+N LQG F++L++CLL+++VRE+Y KW+
Sbjct: 706 AARVMAYLFTIINSLQGVFIFLVYCLLSQQVREQYGKWS 744


>gi|23397691 egf-like module containing, mucin-like, hormone
           receptor-like sequence 2 isoform f [Homo sapiens]
          Length = 763

 Score =  673 bits (1736), Expect = 0.0
 Identities = 368/819 (44%), Positives = 482/819 (58%), Gaps = 104/819 (12%)

Query: 1   MGGRVFL---AFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITT 57
           MGGRVFL   AFCVWLTL                                          
Sbjct: 1   MGGRVFLVFLAFCVWLTL------------------------------------------ 18

Query: 58  PTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDV 117
           P     D   CA      C + S C N      C C+PG+   S   T   E   TC D+
Sbjct: 19  PGAETQDSRGCAR----WCPQDSSCVNATA---CRCNPGFSSFSEIITTPME---TCDDI 68

Query: 118 DECQQNPRL-CKSYGTCVNTLGSYTCQCLPGFK-------FIPEDPKVCTDVNECTSGQN 169
           +EC    ++ C  +  C NT GSY C C PG++       F  E    C DV+EC     
Sbjct: 69  NECATLSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPR 128

Query: 170 PCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNT 229
            C S   C+N +GSY C+C PG++  P  P      +C DVDECSSGQHQCDSSTVCFNT
Sbjct: 129 LCKSYGTCVNTLGSYTCQCLPGFKLKPEDPK-----LCTDVDECSSGQHQCDSSTVCFNT 183

Query: 230 VGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDS 289
           VGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRD 
Sbjct: 184 VGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDY 243

Query: 290 KTSSAEVTIQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGP 349
           K   A  TIQ++++ +DEL+EAPGD+E L    +H +A+ LL  LED++R L+K+L  G 
Sbjct: 244 KPGLANNTIQSILQALDELLEAPGDLETLPRLQQHCVASHLLDGLEDVLRGLSKNLSNGL 303

Query: 350 FTYISPSNTELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTT 409
             +  P+ TEL+L +Q++ D++VT+ Q+ A M+L+W  A  + DPG           M  
Sbjct: 304 LNFSYPAGTELSLEVQKQVDRSVTLRQNQAVMQLDWNQAQKSGDPG-----------MGK 352

Query: 410 LLANASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHL 469
           LLA A L L  +KQ  L E ++  ++      LS V S FLS+N+T+ L+SP+ F FSH 
Sbjct: 353 LLAEAPLVLEPEKQMLLHETHQGLLQDGSPILLSDVISAFLSNNDTQNLSSPVTFTFSH- 411

Query: 470 ESSDGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSH 529
                        + V+  PRQ++LC FW+   +  GHWAT GC  +G+++ ST C+C+H
Sbjct: 412 -------------RSVI--PRQKVLCVFWEHGQNGCGHWATTGCSTIGTRDTSTICRCTH 456

Query: 530 LSSFAILMAHYDV--EDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLC 587
           LSSFA+LMAHYDV  ED  LT+IT +GL++SL CLLL  LTFLL + IQ + T++HL L 
Sbjct: 457 LSSFAVLMAHYDVQEEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQLS 516

Query: 588 ICLFVGSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELY-----FLVV 642
           +CLF+   +FL  I+  G +V   C ++AG LHY +LA   WM LE L L+       VV
Sbjct: 517 LCLFLAHLLFLVAIDQTGHKV--LCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLTVV 574

Query: 643 RVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTF 702
                     + +  +GYGVP + V +SAA     YG P  CWL  E+GF+W FLGPV  
Sbjct: 575 NYSSINRFMKKLMFPVGYGVPAVTVAISAASRPHLYGTPSRCWLQPEKGFIWGFLGPVCA 634

Query: 703 IILCNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDD 762
           I   N V+F+ T+W L  + S +N ++  L+  R L   A AQLF+LGCTW  G+     
Sbjct: 635 IFSVNLVLFLVTLWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFILGCTWCLGILQVGP 694

Query: 763 RSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWA 801
            + V+ Y+FTI+N LQG F++L++CLL+++VRE+Y KW+
Sbjct: 695 AARVMAYLFTIINSLQGVFIFLVYCLLSQQVREQYGKWS 733


>gi|23397687 egf-like module containing, mucin-like, hormone
           receptor-like sequence 2 isoform d [Homo sapiens]
          Length = 681

 Score =  550 bits (1418), Expect = e-156
 Identities = 286/641 (44%), Positives = 402/641 (62%), Gaps = 32/641 (4%)

Query: 171 CHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSS-GQHQCDSSTVCFNT 229
           C   + C+N      CRC PG+         P  T C+D++EC++  +  C   + C+NT
Sbjct: 33  CPQDSSCVNATA---CRCNPGFSSFSEIITTPMET-CDDINECATLSKVSCGKFSDCWNT 88

Query: 230 VGSYSCRCRPGWKPRHGIPN--NQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGR 287
            GSY C C PG++P  G     N+ +  C+DMTFSTWTPPPGVHSQTLSRFFDKVQDLGR
Sbjct: 89  EGSYDCVCSPGYEPVSGAKTFKNESENTCQDMTFSTWTPPPGVHSQTLSRFFDKVQDLGR 148

Query: 288 DSKTSSAEVTIQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPK 347
           D K   A  TIQ++++ +DEL+EAPGD+E L    +H +A+ LL  LED++R L+K+L  
Sbjct: 149 DYKPGLANNTIQSILQALDELLEAPGDLETLPRLQQHCVASHLLDGLEDVLRGLSKNLSN 208

Query: 348 GPFTYISPSNTELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNM 407
           G   +  P+ TEL+L +Q++ D++VT+ Q+ A M+L+W  A  + DPGP+V G++SI  M
Sbjct: 209 GLLNFSYPAGTELSLEVQKQVDRSVTLRQNQAVMQLDWNQAQKSGDPGPSVVGLVSIPGM 268

Query: 408 TTLLANASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFS 467
             LLA A L L  +KQ  L E ++  ++      LS V S FLS+N+T+ L+SP+ F FS
Sbjct: 269 GKLLAEAPLVLEPEKQMLLHETHQGLLQDGSPILLSDVISAFLSNNDTQNLSSPVTFTFS 328

Query: 468 HLESSDGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQC 527
           H              + V+  PRQ++LC FW+   +  GHWAT GC  +G+++ ST C+C
Sbjct: 329 H--------------RSVI--PRQKVLCVFWEHGQNGCGHWATTGCSTIGTRDTSTICRC 372

Query: 528 SHLSSFAILMAHYDV--EDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLH 585
           +HLSSFA+LMAHYDV  ED  LT+IT +GL++SL CLLL  LTFLL + IQ + T++HL 
Sbjct: 373 THLSSFAVLMAHYDVQEEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQ 432

Query: 586 LCICLFVGSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELY-----FL 640
           L +CLF+   +FL  I+  G +V   C ++AG LHY +LA   WM LE L L+       
Sbjct: 433 LSLCLFLAHLLFLVAIDQTGHKV--LCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLT 490

Query: 641 VVRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPV 700
           VV          + +  +GYGVP + V +SAA     YG P  CWL  E+GF+W FLGPV
Sbjct: 491 VVNYSSINRFMKKLMFPVGYGVPAVTVAISAASRPHLYGTPSRCWLQPEKGFIWGFLGPV 550

Query: 701 TFIILCNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIF 760
             I   N V+F+ T+W L  + S +N ++  L+  R L   A AQLF+LGCTW  G+   
Sbjct: 551 CAIFSVNLVLFLVTLWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFILGCTWCLGILQV 610

Query: 761 DDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWA 801
              + V+ Y+FTI+N LQG F++L++CLL+++VRE+Y KW+
Sbjct: 611 GPAARVMAYLFTIINSLQGVFIFLVYCLLSQQVREQYGKWS 651



 Score =  247 bits (630), Expect = 4e-65
 Identities = 113/120 (94%), Positives = 115/120 (95%), Gaps = 3/120 (2%)

Query: 1   MGGRVFL---AFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITT 57
           MGGRVFL   AFCVWLTLPGAETQDSRGCARWCPQ+SSCVNATACRCNPGFSSFSEIITT
Sbjct: 1   MGGRVFLVFLAFCVWLTLPGAETQDSRGCARWCPQDSSCVNATACRCNPGFSSFSEIITT 60

Query: 58  PTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDV 117
           P ETCDDINECAT SKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQD+
Sbjct: 61  PMETCDDINECATLSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDM 120


>gi|40807489 egf-like module containing, mucin-like, hormone
           receptor-like sequence 1 [Homo sapiens]
          Length = 886

 Score =  437 bits (1125), Expect = e-122
 Identities = 275/853 (32%), Positives = 425/853 (49%), Gaps = 105/853 (12%)

Query: 16  PGAETQDSRGCARW---CPQNSSCVNATA---CRCNPGFSSFSEIITTPTE----TCDDI 65
           PG   +D   C++    C  NSSC N +    C C  GFSS +     P +    +C DI
Sbjct: 74  PGVRCKDIDECSQSPQPCGPNSSCKNLSGRYKCSCLDGFSSPTGNDWVPGKPGNFSCTDI 133

Query: 66  NECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPR 125
           NEC T S   C + SDC N+ GSY C C  G+              +TC+DVDEC  +PR
Sbjct: 134 NECLTSSV--CPEHSDCVNSMGSYSCSCQVGFI----------SRNSTCEDVDECA-DPR 180

Query: 126 LCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKV------CTDVNECTSGQNPCHSSTHCLN 179
            C  + TC NT+G+Y+C C PGF+              C D++ECT     C  ++ C N
Sbjct: 181 ACPEHATCNNTVGNYSCFCNPGFESSSGHLSFQGLKASCEDIDECTE---MCPINSTCTN 237

Query: 180 NVGSYQCRCRPGWQPIPGSPNGPNNTV-CEDVDECSSGQHQCDSSTVCFNTVGSYSCRCR 238
             GSY C C PG+ P  G  N  +  V C D+DEC      C  +++C N +GSYSC C 
Sbjct: 238 TPGSYFCTCHPGFAPSNGQLNFTDQGVECRDIDECRQDPSTCGPNSICTNALGSYSCGCI 297

Query: 239 PGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVT- 297
            G+ P         +  C+ + F           + +     ++Q     +    A V+ 
Sbjct: 298 AGFHPNPEGSQKDGNFSCQRVLFKC--------KEDVIPDNKQIQQCQEGTAVKPAYVSF 349

Query: 298 ---IQNVIKLVDELMEAPGDVEALAP------PVRHLIAT------QLLSNLEDIMRILA 342
              I N+  ++D++ E    V +L        PV   I+T      +  S+L  +     
Sbjct: 350 CAQINNIFSVLDKVCENKTTVVSLKNTTESFVPVLKQISTWTKFTKEETSSLATVFLESV 409

Query: 343 KSLPKGPF----TYISPS------NTELTLMIQERGDKNVTMG--QSSARMKLNWAVAAG 390
           +S+    F      I+P+      + E  ++ +E  ++NVT+       +MK+  +    
Sbjct: 410 ESMTLASFWKPSANITPAVRTEYLDIESKVINKECSEENVTLDLVAKGDKMKIGCSTIEE 469

Query: 391 AEDPGPAVAGILSIQNMTTLLANASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFL 450
           +E         +S   M ++L       H       E         ++L+  S V    +
Sbjct: 470 SESTETTGVAFVSFVGMESVLNERFFKDHQAPLTTSE---------IKLKMNSRVVGGIM 520

Query: 451 SHNNTKELNSPILFAFSHLESSDGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWAT 510
           +       + PI++   +++         P  K   P      +C  W +D  +GG W +
Sbjct: 521 TGEKKDGFSDPIIYTLENIQ---------PKQKFERP------ICVSWSTDV-KGGRWTS 564

Query: 511 EGCQVLGSKNGSTTCQCSHLSSFAILMAHYDVE-DWKLTLITRVGLALSLFCLLLCILTF 569
            GC +L +    T C C+ +++ A++MA  ++  D+ L +I+ VG+ +SL CL+L I TF
Sbjct: 565 FGCVILEASETYTICSCNQMANLAVIMASGELTMDFSLYIISHVGIIISLVCLVLAIATF 624

Query: 570 LLVRPIQGSRTTIHLHLCICLFVGSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCW 629
           LL R I+   T +HLHLC+CL +  T+FLAGI     ++G  C ++AG LHY FLA F W
Sbjct: 625 LLCRSIRNHNTYLHLHLCVCLLLAKTLFLAGIHKTDNKMG--CAIIAGFLHYLFLACFFW 682

Query: 630 MSLEGLELYFLV-----VRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYC 684
           M +E + L+ +V     V  F  + +    +C  GYG+P+L+V +SA++  +GYG    C
Sbjct: 683 MLVEAVILFLMVRNLKVVNYFSSRNIKMLHICAFGYGLPMLVVVISASVQPQGYGMHNRC 742

Query: 685 WLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIA 744
           WL+ E GF+WSFLGPV  +I+ N+++   T+W L Q+ S +N ++  LK  R LT  A A
Sbjct: 743 WLNTETGFIWSFLGPVCTVIVINSLLLTWTLWILRQRLSSVNAEVSTLKDTRLLTFKAFA 802

Query: 745 QLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWACLV 804
           QLF+LGC+WV G+F     + V+ Y+FTI+N LQGAF++L+HCLLN +VREEY++W   +
Sbjct: 803 QLFILGCSWVLGIFQIGPVAGVMAYLFTIINSLQGAFIFLIHCLLNGQVREEYKRW---I 859

Query: 805 AGGSKYSEFTSTT 817
            G +K S  + T+
Sbjct: 860 TGKTKPSSQSQTS 872



 Score =  132 bits (333), Expect = 1e-30
 Identities = 75/194 (38%), Positives = 100/194 (51%), Gaps = 22/194 (11%)

Query: 76  CGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVN 135
           C  ++ C NT  SY C C  G+   +G   FK+     C+D+DEC Q+P+ C    +C N
Sbjct: 41  CPAYATCTNTVDSYYCACKQGFLSSNGQNHFKDPGVR-CKDIDECSQSPQPCGPNSSCKN 99

Query: 136 TLGSYTCQCLPGFK------FIPEDPK--VCTDVNEC-TSGQNPCHSSTHCLNNVGSYQC 186
             G Y C CL GF       ++P  P    CTD+NEC TS   P HS   C+N++GSY C
Sbjct: 100 LSGRYKCSCLDGFSSPTGNDWVPGKPGNFSCTDINECLTSSVCPEHSD--CVNSMGSYSC 157

Query: 187 RCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHG 246
            C+ G+           N+ CEDVDEC+     C     C NTVG+YSC C PG++   G
Sbjct: 158 SCQVGFI--------SRNSTCEDVDECAD-PRACPEHATCNNTVGNYSCFCNPGFESSSG 208

Query: 247 IPNNQ-KDTVCEDM 259
             + Q     CED+
Sbjct: 209 HLSFQGLKASCEDI 222



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 55/161 (34%), Positives = 78/161 (48%), Gaps = 25/161 (15%)

Query: 108 NESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIP-----EDPKV-CTDV 161
           N   N C+D         LC +Y TC NT+ SY C C  GF         +DP V C D+
Sbjct: 29  NTKGNNCRD-------STLCPAYATCTNTVDSYYCACKQGFLSSNGQNHFKDPGVRCKDI 81

Query: 162 NECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGS---PNGPNNTVCEDVDECSSGQH 218
           +EC+    PC  ++ C N  G Y+C C  G+    G+   P  P N  C D++EC +   
Sbjct: 82  DECSQSPQPCGPNSSCKNLSGRYKCSCLDGFSSPTGNDWVPGKPGNFSCTDINECLTSS- 140

Query: 219 QCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDM 259
            C   + C N++GSYSC C+ G+  R        ++ CED+
Sbjct: 141 VCPEHSDCVNSMGSYSCSCQVGFISR--------NSTCEDV 173


>gi|133930786 egf-like module-containing mucin-like receptor 3 [Homo
           sapiens]
          Length = 652

 Score =  311 bits (798), Expect = 1e-84
 Identities = 209/672 (31%), Positives = 326/672 (48%), Gaps = 90/672 (13%)

Query: 171 CHSSTHCLNNVGSYQCRCRPGWQPIPGSP--NGPNNTVCEDVDECSSGQH-QCDSSTVCF 227
           C  +  C+NN     C C  G+    G      P  T C D++EC+      C  + VC+
Sbjct: 31  CPPNASCVNNT---HCTCNHGYTSGSGQKLFTFPLET-CNDINECTPPYSVYCGFNAVCY 86

Query: 228 NTVGSYSCRCRPGWKPRHGIP--NNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDL 285
           N  GS+ C+C PG++   G    +N  +  C+D T S  T       + L +  DK + L
Sbjct: 87  NVEGSFYCQCVPGYRLHSGNEQFSNSNENTCQDTTSSKTTEG----RKELQKIVDKFESL 142

Query: 286 ----------GRDSKTSSAEVTIQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLE 335
                     GR   +S+A   +++V   V E         AL  P + ++  Q      
Sbjct: 143 LTNQTLWRTEGRQEISSTATTILRDVESKVLET--------ALKDPEQKVLKIQ-----N 189

Query: 336 DIMRILAKSLPKGPFTYISPSNTELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPG 395
           D + I  +++                   +ER   N+ +  +S  ++ +  +    +  G
Sbjct: 190 DSVAIETQAITDN--------------CSEERKTFNLNVQMNSMDIRCSDIIQGDTQ--G 233

Query: 396 PAVAGILSIQNMTTLLANASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNT 455
           P+    +S  ++  ++         KK    +++Y +S           V S  +     
Sbjct: 234 PSAIAFISYSSLGNIINATFFEEMDKK----DQVYLNS----------QVVSAAIGPKRN 279

Query: 456 KELNSPILFAFSHLESSDGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQV 515
             L+  +   F H++ +       P  K V         C +WKS + +G  W+ +GC +
Sbjct: 280 VSLSKSVTLTFQHVKMT-------PSTKKVF--------CVYWKS-TGQGSQWSRDGCFL 323

Query: 516 LGSKNGSTTCQCSHLSSFAILMA-HYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRP 574
           +      T C CSHLSSFA+LMA     ED  LT+IT VGL++SL CLLL  LTFLL + 
Sbjct: 324 IHVNKSHTMCNCSHLSSFAVLMALTSQEEDPVLTVITYVGLSVSLLCLLLAALTFLLCKA 383

Query: 575 IQGSRTTIHLHLCICLFVGSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEG 634
           I+ + T++HL L +CLF+   +FL GI+    +V   C ++AG LHY +LAAF WM LEG
Sbjct: 384 IRNTSTSLHLQLSLCLFLAHLLFLVGIDRTEPKV--LCSIIAGALHYLYLAAFTWMLLEG 441

Query: 635 LELYF----LVVRVFQGQGLSTRWLCL-IGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFE 689
           + L+     L V  +       +W+   +GYGVP + V +SAA +   YG    CWL  +
Sbjct: 442 VHLFLTARNLTVVNYSSINRLMKWIMFPVGYGVPAVTVAISAASWPHLYGTADRCWLHLD 501

Query: 690 QGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLL 749
           QGF+WSFLGPV  I   N V+F+   W L +K S +N ++  ++  R L   A AQLF+L
Sbjct: 502 QGFMWSFLGPVCAIFSANLVLFILVFWILKRKLSSLNSEVSTIQNTRMLAFKATAQLFIL 561

Query: 750 GCTWVFGLFIFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWACLVAGGSK 809
           GCTW  GL      + V+ Y+FTI+N LQG F++L++CLL+++V+++Y+KW   +     
Sbjct: 562 GCTWCLGLLQVGPAAQVMAYLFTIINSLQGFFIFLVYCLLSQQVQKQYQKWFREIVKSKS 621

Query: 810 YSEFTSTTSGTG 821
            SE  + +S  G
Sbjct: 622 ESETYTLSSKMG 633



 Score =  114 bits (285), Expect = 4e-25
 Identities = 55/109 (50%), Positives = 69/109 (63%), Gaps = 2/109 (1%)

Query: 10  CVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFS--EIITTPTETCDDINE 67
           C  L+L GA TQ ++     CP N+SCVN T C CN G++S S  ++ T P ETC+DINE
Sbjct: 11  CFLLSLFGAVTQKTKTSCAKCPPNASCVNNTHCTCNHGYTSGSGQKLFTFPLETCNDINE 70

Query: 68  CATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQD 116
           C  P  V CG  + C+N EGS+ C C PGY   SG + F N +ENTCQD
Sbjct: 71  CTPPYSVYCGFNAVCYNVEGSFYCQCVPGYRLHSGNEQFSNSNENTCQD 119



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 32/105 (30%), Positives = 47/105 (44%), Gaps = 8/105 (7%)

Query: 72  SKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRL-CKSY 130
           +K SC K     +   +  C C+ GY   SG K F    E TC D++EC     + C   
Sbjct: 24  TKTSCAKCPPNASCVNNTHCTCNHGYTSGSGQKLFTFPLE-TCNDINECTPPYSVYCGFN 82

Query: 131 GTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSST 175
             C N  GS+ CQC+PG++    + +         S +N C  +T
Sbjct: 83  AVCYNVEGSFYCQCVPGYRLHSGNEQF------SNSNENTCQDTT 121


>gi|6912464 latrophilin 2 precursor [Homo sapiens]
          Length = 1403

 Score =  294 bits (753), Expect = 2e-79
 Identities = 153/368 (41%), Positives = 218/368 (59%), Gaps = 30/368 (8%)

Query: 444  AVNSIFLSHNNTKE-----LNSPILFAFSHLESSDGEAGRDPPAKDVMPGPRQELLCAFW 498
            AVNS  +S +  KE     L  P+LF   H++                P       C+FW
Sbjct: 735  AVNSHVISVSINKESSRVYLTDPVLFTLPHID----------------PDNYFNANCSFW 778

Query: 499  K-SDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHYD------VEDWKLTLIT 551
              S+    G+W+T+GC+++ +    TTC CSHL++FAILMAH +      V +  LT+IT
Sbjct: 779  NYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKDGVHELLLTVIT 838

Query: 552  RVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGSTIFLAGIENEGGQVGLR 611
             VG+ +SL CL +CI TF   R +Q  R TIH +LCI LF+   IFL GI+    +  + 
Sbjct: 839  WVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIGIDKT--KYAIA 896

Query: 612  CRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWLCLIGYGVPLLIVGVSA 671
            C + AGLLH+ FLAAF WM LEG++LY ++V VF+ +    ++  + GY  P  +VGVSA
Sbjct: 897  CPIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVGVSA 956

Query: 672  AIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSEINPDMKK 731
            AI  K YG  + CWL  +  F+WSF+GPVTFIIL N +  V T+ K+ +  + + PD  +
Sbjct: 957  AIDYKSYGTEKACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHSNTLKPDSSR 1016

Query: 732  LKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNK 791
            L+  ++  + A A L LLG TW FGL   ++ ++V+ Y+FTI N  QG F+++ HC L K
Sbjct: 1017 LENIKSWVLGAFALLCLLGLTWSFGLLFINEETIVMAYLFTIFNAFQGVFIFIFHCALQK 1076

Query: 792  KVREEYRK 799
            KVR+EY K
Sbjct: 1077 KVRKEYGK 1084


>gi|57165355 latrophilin 1 isoform 1 precursor [Homo sapiens]
          Length = 1474

 Score =  291 bits (746), Expect = 1e-78
 Identities = 159/399 (39%), Positives = 232/399 (58%), Gaps = 35/399 (8%)

Query: 445  VNSIFLSHNNTKE-----LNSPILFAFSHLESSDGEAGRDPPAKDVMPGPRQELLCAFWK 499
            VNS  ++ +  KE     L  P++F  +HLE  +                     C+FW 
Sbjct: 763  VNSQVIAASINKESSRVFLMDPVIFTVAHLEDKNHFNAN----------------CSFWN 806

Query: 500  -SDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHYDVEDWK-----LTLITRV 553
             S+    G+W+T+GC+++ S    TTC CSHL++FA+LMAH ++   +     L++IT V
Sbjct: 807  YSERSMLGYWSTQGCRLVESNKTHTTCACSHLTNFAVLMAHREIYQGRINELLLSVITWV 866

Query: 554  GLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGSTIFLAGIENEGGQVGLRCR 613
            G+ +SL CL +CI TF  +R +Q  R TIH +LCI LF+   +FL GI+    Q  + C 
Sbjct: 867  GIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELLFLVGIDKT--QYEIACP 924

Query: 614  LVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAI 673
            + AGLLHY FLAAF W+ LEG+ LY L+V VF+ +   T++  L GY  P L+VG++AAI
Sbjct: 925  IFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALVVGIAAAI 984

Query: 674  YSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSEINPDMKKLK 733
              + YG  + CWL  +  F+WSF+GPV+F+I+ N V  + T+ K+ +  S + PD  +L 
Sbjct: 985  DYRSYGTEKACWLRVDNYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLD 1044

Query: 734  KARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKV 793
              ++  + AIA LFLLG TW FGL   +  S+V+ Y+FT  N  QG F+++ HC L KKV
Sbjct: 1045 NIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQGVFIFVFHCALQKKV 1104

Query: 794  REEYRKWACLVAGGSKYSEFTSTTSGT-GHNQTRALRAS 831
             +EY K  CL      Y    S   GT G  +T A+R++
Sbjct: 1105 HKEYSK--CL---RHSYCCIRSPPGGTHGSLKTSAMRSN 1138


>gi|41281557 latrophilin 1 isoform 2 precursor [Homo sapiens]
          Length = 1469

 Score =  291 bits (746), Expect = 1e-78
 Identities = 159/399 (39%), Positives = 232/399 (58%), Gaps = 35/399 (8%)

Query: 445  VNSIFLSHNNTKE-----LNSPILFAFSHLESSDGEAGRDPPAKDVMPGPRQELLCAFWK 499
            VNS  ++ +  KE     L  P++F  +HLE  +                     C+FW 
Sbjct: 758  VNSQVIAASINKESSRVFLMDPVIFTVAHLEDKNHFNAN----------------CSFWN 801

Query: 500  -SDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHYDVEDWK-----LTLITRV 553
             S+    G+W+T+GC+++ S    TTC CSHL++FA+LMAH ++   +     L++IT V
Sbjct: 802  YSERSMLGYWSTQGCRLVESNKTHTTCACSHLTNFAVLMAHREIYQGRINELLLSVITWV 861

Query: 554  GLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGSTIFLAGIENEGGQVGLRCR 613
            G+ +SL CL +CI TF  +R +Q  R TIH +LCI LF+   +FL GI+    Q  + C 
Sbjct: 862  GIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELLFLVGIDKT--QYEIACP 919

Query: 614  LVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAI 673
            + AGLLHY FLAAF W+ LEG+ LY L+V VF+ +   T++  L GY  P L+VG++AAI
Sbjct: 920  IFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALVVGIAAAI 979

Query: 674  YSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSEINPDMKKLK 733
              + YG  + CWL  +  F+WSF+GPV+F+I+ N V  + T+ K+ +  S + PD  +L 
Sbjct: 980  DYRSYGTEKACWLRVDNYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLD 1039

Query: 734  KARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKV 793
              ++  + AIA LFLLG TW FGL   +  S+V+ Y+FT  N  QG F+++ HC L KKV
Sbjct: 1040 NIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQGVFIFVFHCALQKKV 1099

Query: 794  REEYRKWACLVAGGSKYSEFTSTTSGT-GHNQTRALRAS 831
             +EY K  CL      Y    S   GT G  +T A+R++
Sbjct: 1100 HKEYSK--CL---RHSYCCIRSPPGGTHGSLKTSAMRSN 1133


>gi|148806925 EGF, latrophilin and seven transmembrane domain
           containing 1 [Homo sapiens]
          Length = 690

 Score =  291 bits (746), Expect = 1e-78
 Identities = 209/702 (29%), Positives = 328/702 (46%), Gaps = 104/702 (14%)

Query: 158 CTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQ 217
           C+    CT  + PC  +  C    G   C C  G+       +G   T+CED +EC +  
Sbjct: 16  CSYTQNCT--KTPCLPNAKCEIRNGIEACYCNMGF-------SGNGVTICEDDNECGNLT 66

Query: 218 HQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVH------ 271
             C  +  C NT GSY C C PG++      +NQ   +  D T          H      
Sbjct: 67  QSCGENANCTNTEGSYYCMCVPGFRSS----SNQDRFITNDGTVCIENVNANCHLDNVCI 122

Query: 272 ----SQTLSR--------------FFDKVQDL-------------------GRDSKTSSA 294
               ++TL++              + + V DL                   G  + T SA
Sbjct: 123 AANINKTLTKIRSIKEPVALLQEVYRNSVTDLSPTDIITYIEILAESSSLLGYKNNTISA 182

Query: 295 EVTIQN-----VIKLVDELMEAPGDV--EALAPPVRHLIATQLLSNLEDIMRILAKSLPK 347
           + T+ N      +K V+  ++    V  + L+   R    T+L+  +E     +++S  K
Sbjct: 183 KDTLSNSTLTEFVKTVNNFVQRDTFVVWDKLSVNHRRTHLTKLMHTVEQATLRISQSFQK 242

Query: 348 GPFTYISPSNTELTLMIQERGDKNVT-----MGQSSARMKLNWAVAAGAEDPGPAVAGIL 402
              T    ++T++ L +      N+      M      + +     A  +  G      +
Sbjct: 243 T--TEFDTNSTDIALKVFFFDSYNMKHIHPHMNMDGDYINIFPKRKAAYDSNGNVAVAFV 300

Query: 403 SIQNMTTLLANASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHN--NTKELNS 460
             +++  LL+++   L   +  +  E  E        R +S+V S+ +S N     EL  
Sbjct: 301 YYKSIGPLLSSSDNFLLKPQNYDNSEEEE--------RVISSVISVSMSSNPPTLYELEK 352

Query: 461 PILFAFSHLESSDGEAGRDPPAKDVMPGPRQELLCAFWKSDSDR-GGHWATEGCQVLGSK 519
            I F  SH + +D                R   LCAFW    D   G W++EGC++  S 
Sbjct: 353 -ITFTLSHRKVTD----------------RYRSLCAFWNYSPDTMNGSWSSEGCELTYSN 395

Query: 520 NGSTTCQCSHLSSFAILMAH---YDVEDWK-LTLITRVGLALSLFCLLLCILTFLLVRPI 575
              T+C+C+HL+ FAILM+      ++D+  LT IT++G+ +SL CL +CI TF     I
Sbjct: 396 ETHTSCRCNHLTHFAILMSSGPSIGIKDYNILTRITQLGIIISLICLAICIFTFWFFSEI 455

Query: 576 QGSRTTIHLHLCICLFVGSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGL 635
           Q +RTTIH +LC  LF+   +FL GI     +  L C ++AGLLHY FLAAF WM +EG+
Sbjct: 456 QSTRTTIHKNLCCSLFLAELVFLVGINTNTNK--LFCSIIAGLLHYFFLAAFAWMCIEGI 513

Query: 636 ELYFLVVRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWS 695
            LY +VV V   +G   +   + GY  P ++VG SAA+  + YG  + CWL  E  F+WS
Sbjct: 514 HLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSAALGYRYYGTTKVCWLSTENNFIWS 573

Query: 696 FLGPVTFIILCNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVF 755
           F+GP   IIL N + F   ++K+ +  + + P++   +  R+    A+A LFLLG TW+F
Sbjct: 574 FIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCFENIRSCARGALALLFLLGTTWIF 633

Query: 756 GLFIFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEY 797
           G+      S+V  Y+FT+ N  QG F++L  C+L++K++EEY
Sbjct: 634 GVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCVLSRKIQEEY 675



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 33/88 (37%), Positives = 42/88 (47%), Gaps = 10/88 (11%)

Query: 30  CPQNSSCV---NATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTE 86
           C  N+ C       AC CN GFS     I      C+D NEC   ++ SCG+ ++C NTE
Sbjct: 27  CLPNAKCEIRNGIEACYCNMGFSGNGVTI------CEDDNECGNLTQ-SCGENANCTNTE 79

Query: 87  GSYDCVCSPGYEPVSGAKTFKNESENTC 114
           GSY C+C PG+   S    F       C
Sbjct: 80  GSYYCMCVPGFRSSSNQDRFITNDGTVC 107



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 31/109 (28%), Positives = 42/109 (38%), Gaps = 11/109 (10%)

Query: 72  SKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYG 131
           +K  C   + C    G   C C+ G         F       C+D +EC    + C    
Sbjct: 23  TKTPCLPNAKCEIRNGIEACYCNMG---------FSGNGVTICEDDNECGNLTQSCGENA 73

Query: 132 TCVNTLGSYTCQCLPGFKFIP-EDPKVCTDVNECTSGQNP-CHSSTHCL 178
            C NT GSY C C+PGF+    +D  +  D   C    N  CH    C+
Sbjct: 74  NCTNTEGSYYCMCVPGFRSSSNQDRFITNDGTVCIENVNANCHLDNVCI 122


>gi|163792198 latrophilin 3 precursor [Homo sapiens]
          Length = 1469

 Score =  280 bits (717), Expect = 3e-75
 Identities = 155/394 (39%), Positives = 227/394 (57%), Gaps = 25/394 (6%)

Query: 450  LSHNNTKELNSPILFAFSHLESSDGEAGRDPPAKDVMPGPRQELL----CAFWK-SDSDR 504
            LS N++  +NSP++ A  + E S+     DP    V    + E      C+FW  S    
Sbjct: 769  LSTNHSVIVNSPVITAAINKEFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTM 828

Query: 505  GGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHYDVE------DWKLTLITRVGLALS 558
             G+W+T+GC++L +    TTC C+HL++FA+LMAH +V+      D  L +IT VG+ LS
Sbjct: 829  TGYWSTQGCRLLTTNKTHTTCSCNHLTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLS 888

Query: 559  LFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGSTIFLAGIENEGGQVGLRCRLVAGL 618
            L CLL+CI TF   R +Q  R TIH +LCI LFV   +FL GI      +   C + A L
Sbjct: 889  LVCLLICIFTFCFFRGLQSDRNTIHKNLCISLFVAELLFLIGINRTDQPIA--CAVFAAL 946

Query: 619  LHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGY 678
            LH+ FLAAF WM LEG++LY ++V VF+ +    ++  L+GYG+P LIV VSAA+  + Y
Sbjct: 947  LHFFFLAAFTWMFLEGVQLYIMLVEVFESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSY 1006

Query: 679  GRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSEINPDMKKLKK---- 734
            G  + CWL  +  F+WSF+GP T II+ N +     ++K+    + + P+   L      
Sbjct: 1007 GTDKVCWLRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNINYE 1066

Query: 735  -----ARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGAFLYLLHCLL 789
                  ++  I AIA L LLG TW FGL   ++ ++++ Y+FTI N LQG F+++ HC+L
Sbjct: 1067 DNRPFIKSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVL 1126

Query: 790  NKKVREEYRKWA---CLVAGGSKYSEFTSTTSGT 820
             KKVR+EY K     C     ++ S  +  TSG+
Sbjct: 1127 QKKVRKEYGKCLRTHCCSGKSTESSIGSGKTSGS 1160


>gi|45433552 G protein-coupled receptor 133 [Homo sapiens]
          Length = 874

 Score =  191 bits (486), Expect = 2e-48
 Identities = 113/316 (35%), Positives = 171/316 (54%), Gaps = 19/316 (6%)

Query: 495 CAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHYDVE-----DWKLTL 549
           CAF    S  G  W+  GC +       + C+C+HL++FAILM    +E        L+ 
Sbjct: 510 CAFLDFSSGEGV-WSNHGCALTRGNLTYSVCRCTHLTNFAILMQVVPLELARGHQVALSS 568

Query: 550 ITRVGLALSLFCLLLCILTFLL---VRPIQGSRTTIHLHLCICLFVGSTIFLAGIENEGG 606
           I+ VG +LS+ CL+  ++TF +   V  I+  R  IH +L   + V   + L     E G
Sbjct: 569 ISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPG 628

Query: 607 QVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWLCLIGYGVPLLI 666
                C+++A LLHY FL+AF WM +EGL LY +V++VF  +    R+   +G+G PLLI
Sbjct: 629 TTP--CQVMAVLLHYFFLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRYYYGMGWGFPLLI 686

Query: 667 VGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSEIN 726
             +S +     YG    CWL    G +W+F+ P  F+I+ N  I +     +T+  S+I+
Sbjct: 687 CIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPALFVIVVNIGILIA----VTRVISQIS 742

Query: 727 PDMKKL---KKARALTITAIAQLF-LLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGAFL 782
            D  K+     A  LT  A+A L  +LG +WVFG+   +  ++V  Y+F  LN LQG F+
Sbjct: 743 ADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGLFI 802

Query: 783 YLLHCLLNKKVREEYR 798
           +L HCLLN +VR  ++
Sbjct: 803 FLFHCLLNSEVRAAFK 818


>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
            sapiens]
          Length = 3014

 Score =  189 bits (481), Expect = 7e-48
 Identities = 122/408 (29%), Positives = 196/408 (48%), Gaps = 39/408 (9%)

Query: 426  LEEIYESSIRGVQLRRLSAVNSIFLSHNNTKE-------LNSPILFAFSHLESSDGEAGR 478
            L E Y+   R ++L     +N+  +S     E       L  P+L  F+ LE  +     
Sbjct: 2351 LPERYDPDRRSLRLPHRPIINTPMVSTLVYSEGAPLPRPLERPVLVEFALLEVEE----- 2405

Query: 479  DPPAKDVMPGPRQELLCAFWKSDSDRGGH--WATEGCQVLGSKNGSTTCQCSHLSSFAIL 536
                       R + +C FW      GG   W+  GC++L        CQCSH +SFA+L
Sbjct: 2406 -----------RTKPVCVFWNHSLAVGGTGGWSARGCELLSRNRTHVACQCSHTASFAVL 2454

Query: 537  M---AHYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVG 593
            M      + E   L ++T   ++LSL  LL+  +   LVR ++ +  +IH HL + LF+ 
Sbjct: 2455 MDISRRENGEVLPLKIVTYAAVSLSLAALLVAFVLLSLVRMLRSNLHSIHKHLAVALFLS 2514

Query: 594  STIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTR 653
              +F+ GI          C +VA LLHY +++ F W  +E L +Y ++  V        R
Sbjct: 2515 QLVFVIGINQTENP--FLCTVVAILLHYIYMSTFAWTLVESLHVYRMLTEVRNIDTGPMR 2572

Query: 654  WLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVT 713
            +  ++G+G+P ++ G++  +  +GYG P +CWL  +   +WSF GP+  +I+ N V  V 
Sbjct: 2573 FYYVVGWGIPAIVTGLAVGLDPQGYGNPDFCWLSLQDTLIWSFAGPIGAVIIINTVTSVL 2632

Query: 714  TVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTI 773
            +     Q+           K   +L  TA   L L+  TW+ GL   +  +L   Y+F I
Sbjct: 2633 SAKVSCQR----KHHYYGKKGIVSLLRTAFLLLLLISATWLLGLLAVNRDALSFHYLFAI 2688

Query: 774  LNCLQGAFLYLLHCLLNKKVREEYRKWACLVAGGSK-YSEFTSTTSGT 820
             + LQG F+ L HC+LN++VR+  +     V GG K + E ++TT  T
Sbjct: 2689 FSGLQGPFVLLFHCVLNQEVRKHLKG----VLGGRKLHLEDSATTRAT 2732



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 34/113 (30%), Positives = 49/113 (43%), Gaps = 25/113 (22%)

Query: 37   VNATACRCNPGFSSFSEIITTPTETCD-DINECATPSKVSCGKFSDCWNTEGSYDCVCSP 95
            +N   CRC PGF+          + C+ +I+ C +     CG    C + EG Y C C  
Sbjct: 1344 INGLRCRCPPGFTG---------DYCETEIDLCYSD---PCGANGRCRSREGGYTCEC-- 1389

Query: 96   GYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTL-GSYTCQCLPG 147
             +E  +G     +     C +         +CK+ GTCVN L G + C C PG
Sbjct: 1390 -FEDFTGEHCEVDARSGRCAN--------GVCKNGGTCVNLLIGGFHCVCPPG 1433



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 55/232 (23%), Positives = 79/232 (34%), Gaps = 57/232 (24%)

Query: 24   RGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCW 83
            RGC +      +  N      N      + +     + CD  + C +     C   S C 
Sbjct: 1838 RGCMQGVRMGGTPTNVATLNMN------NALKVRVKDGCDVDDPCTSSP---CPPNSRCH 1888

Query: 84   NTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGS---Y 140
            +    Y CVC  GY  ++            C  VD C  NP  C++ G CV + GS   Y
Sbjct: 1889 DAWEDYSCVCDKGYLGIN------------C--VDACHLNP--CENMGACVRSPGSPQGY 1932

Query: 141  TCQCLPGFKFIPEDPKVCTDVNECTSG--QNPCHSSTHCLNNVG--------SYQCRCRP 190
             C+C P       + K+      C  G   NP     HC  + G        + QC+C+ 
Sbjct: 1933 VCECGPSHYGPYCENKLDL---PCPRGWWGNPVCGPCHCAVSKGFDPDCNKTNGQCQCKE 1989

Query: 191  GWQPIPGSPNGPNNTVCEDVDECSSGQHQ--CDSSTVCFNTVGSYSCRCRPG 240
             +  +           C   D    G H   CD +T          C C+PG
Sbjct: 1990 NYYKLLA------QDTCLPCDCFPHGSHSRTCDMAT--------GQCACKPG 2027



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 29/103 (28%), Positives = 45/103 (43%), Gaps = 20/103 (19%)

Query: 91   CVCSPGYEPVSGAKTFKNESENTCQ-DVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFK 149
            C C PG+            + + C+ ++D C  +P  C + G C +  G YTC+C     
Sbjct: 1349 CRCPPGF------------TGDYCETEIDLCYSDP--CGANGRCRSREGGYTCECFE--D 1392

Query: 150  FIPEDPKVCTDVNECTSGQNPCHSSTHCLN-NVGSYQCRCRPG 191
            F  E  +V      C +G   C +   C+N  +G + C C PG
Sbjct: 1393 FTGEHCEVDARSGRCANG--VCKNGGTCVNLLIGGFHCVCPPG 1433


>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
            sapiens]
          Length = 2923

 Score =  166 bits (420), Expect = 8e-41
 Identities = 112/404 (27%), Positives = 189/404 (46%), Gaps = 37/404 (9%)

Query: 412  ANASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLS---HNNT----KELNSPILF 464
            A AS+ ++      L   Y+   R +++ +   +N+  +S   H++     + L+ P+  
Sbjct: 2245 AVASVIIYRTLAGLLPHNYDPDKRSLRVPKRPIINTPVVSISVHDDEELLPRALDKPVTV 2304

Query: 465  AFSHLESSDGEAGRDPPAKDVMPGPRQELLCAFWKSD---SDRGGHWATEGCQVLGSKNG 521
             F  LE+ +                R + +C FW      S  GG W+  GC+V+     
Sbjct: 2305 QFRLLETEE----------------RTKPICVFWNHSILVSGTGG-WSARGCEVVFRNES 2347

Query: 522  STTCQCSHLSSFAILM---AHYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGS 578
              +CQC+H++SFA+LM      + E   L  +T V L ++L  LLL      L+R ++ +
Sbjct: 2348 HVSCQCNHMTSFAVLMDVSRRENGEILPLKTLTYVALGVTLAALLLTFFFLTLLRILRSN 2407

Query: 579  RTTIHLHLCICLFVGSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELY 638
            +  I  +L   L +   +FL GI      +   C ++A LLH+ +L  F W  LE L LY
Sbjct: 2408 QHGIRRNLTAALGLAQLVFLLGINQ--ADLPFACTVIAILLHFLYLCTFSWALLEALHLY 2465

Query: 639  FLVVRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLG 698
              +  V        R+  ++G+GVP  I G++  +  +GYG P +CWL      +WSF G
Sbjct: 2466 RALTEVRDVNTGPMRFYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLIWSFAG 2525

Query: 699  PVTFIILCNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLF 758
            PV F +  +  +++          +      +K      L   + A L LL  TW+  L 
Sbjct: 2526 PVAFAVSMSVFLYILAA---RASCAAQRQGFEKKGPVSGLQ-PSFAVLLLLSATWLLALL 2581

Query: 759  IFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWAC 802
              +  +L+  Y+F   NC+QG F++L + +L+K+VR+   K AC
Sbjct: 2582 SVNSDTLLFHYLFATCNCIQGPFIFLSYVVLSKEVRKAL-KLAC 2624



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 34/112 (30%), Positives = 44/112 (39%), Gaps = 23/112 (20%)

Query: 37   VNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPG 96
            V    CRC PGF+   +   T  + C             CG    C + EG Y C+C  G
Sbjct: 1269 VGGLRCRCPPGFTG--DYCETEVDLC---------YSRPCGPHGRCRSREGGYTCLCRDG 1317

Query: 97   YEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTL-GSYTCQCLPG 147
            Y   +G     +     C         P +CK+ GTCVN L G + C C  G
Sbjct: 1318 Y---TGEHCEVSARSGRC--------TPGVCKNGGTCVNLLVGGFKCDCPSG 1358



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 32/109 (29%), Positives = 44/109 (40%), Gaps = 18/109 (16%)

Query: 134  VNTLGSYTCQCLPGFKFIPEDPKVC-TDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGW 192
            ++ +G   C+C PGF         C T+V+ C S   PC     C +  G Y C CR G+
Sbjct: 1266 IHPVGGLRCRCPPGFT-----GDYCETEVDLCYS--RPCGPHGRCRSREGGYTCLCRDGY 1318

Query: 193  QPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFN-TVGSYSCRCRPG 240
                    G +  V      C+ G   C +   C N  VG + C C  G
Sbjct: 1319 -------TGEHCEVSARSGRCTPG--VCKNGGTCVNLLVGGFKCDCPSG 1358



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 32/107 (29%), Positives = 45/107 (42%), Gaps = 20/107 (18%)

Query: 87   GSYDCVCSPGYEPVSGAKTFKNESENTCQ-DVDECQQNPRLCKSYGTCVNTLGSYTCQCL 145
            G   C C PG+            + + C+ +VD C   P  C  +G C +  G YTC C 
Sbjct: 1270 GGLRCRCPPGF------------TGDYCETEVDLCYSRP--CGPHGRCRSREGGYTCLCR 1315

Query: 146  PGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLN-NVGSYQCRCRPG 191
             G  +  E  +V      CT G   C +   C+N  VG ++C C  G
Sbjct: 1316 DG--YTGEHCEVSARSGRCTPG--VCKNGGTCVNLLVGGFKCDCPSG 1358



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 27/87 (31%), Positives = 42/87 (48%), Gaps = 19/87 (21%)

Query: 158  CTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQ 217
            C+  + C S  NPC ++++C N+  SY C C PG+        G N T   D++ C   +
Sbjct: 1791 CSLPDPCDS--NPCPANSYCSNDWDSYSCSCDPGYY-------GDNCTNVCDLNPC---E 1838

Query: 218  HQCDSSTVCFNTVGS---YSCRCRPGW 241
            HQ    +VC     +   Y+C C P +
Sbjct: 1839 HQ----SVCTRKPSAPHGYTCECPPNY 1861



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 52/199 (26%), Positives = 67/199 (33%), Gaps = 52/199 (26%)

Query: 76   CGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVN 135
            C   S C N   SY C C PGY              + C +V  C  NP  C+    C  
Sbjct: 1802 CPANSYCSNDWDSYSCSCDPGY------------YGDNCTNV--CDLNP--CEHQSVCTR 1845

Query: 136  TLGS---YTCQCLPGFKFIPEDPKVCTDVNE-CTSGQ------NPCHSST------HCLN 179
               +   YTC+C P +      P   T +++ C  G        PC+          C  
Sbjct: 1846 KPSAPHGYTCECPPNYL----GPYCETRIDQPCPRGWWGHPTCGPCNCDVSKGFDPDC-- 1899

Query: 180  NVGSYQCRCRPGWQPIPGS---------PNGPNNTVCEDVD---ECSSG--QHQCDSSTV 225
            N  S +C C+      PGS         P G  + VC+  D    C  G    QCD    
Sbjct: 1900 NKTSGECHCKENHYRPPGSPTCLLCDCYPTGSLSRVCDPEDGQCPCKPGVIGRQCDRCDN 1959

Query: 226  CFNTVGSYSCRCRPGWKPR 244
             F  V +  C       PR
Sbjct: 1960 PFAEVTTNGCEVNYDSCPR 1978



 Score = 36.6 bits (83), Expect = 0.099
 Identities = 22/69 (31%), Positives = 30/69 (43%), Gaps = 13/69 (18%)

Query: 178  LNNVGSYQCRCRPGWQPIPGSPNGPNNTVCE-DVDECSSGQHQCDSSTVCFNTVGSYSCR 236
            ++ VG  +CRC PG+              CE +VD C S    C     C +  G Y+C 
Sbjct: 1266 IHPVGGLRCRCPPGF----------TGDYCETEVDLCYS--RPCGPHGRCRSREGGYTCL 1313

Query: 237  CRPGWKPRH 245
            CR G+   H
Sbjct: 1314 CRDGYTGEH 1322


>gi|223556012 G-protein coupled receptor 113 isoform 1 [Homo sapiens]
          Length = 1079

 Score =  159 bits (402), Expect = 1e-38
 Identities = 106/322 (32%), Positives = 160/322 (49%), Gaps = 14/322 (4%)

Query: 495  CAFWKSDSDRG-GHWATEGCQV-LGSKNGSTTCQCSHLSSFAILMAHYDV-EDWKLTLIT 551
            C FW     +G G W+ EGCQ  + S + +  C C HL++F++LM+ + V E+  L L+T
Sbjct: 715  CVFWDHSLFQGRGGWSKEGCQAQVASASPTAQCLCQHLTAFSVLMSPHTVPEEPALALLT 774

Query: 552  RVGLALSLFCLLLCILTFLLV------RPIQGSRTTIHLHLCICLFVGSTIFLAGIENEG 605
            +VGL  S+  LL+C+  + LV        I   R    L++  CL    T FL       
Sbjct: 775  QVGLGASILALLVCLGVYWLVWRVVVRNKISYFRHAALLNMVFCLLAADTCFLGAPFLSP 834

Query: 606  GQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQ--GQGLSTRWLCLIGYGVP 663
            G     C   A L H+ +LA F WM  + L L   ++ VF    +      + L+GY  P
Sbjct: 835  GPRSPLCLAAAFLCHFLYLATFFWMLAQALVLAHQLLFVFHQLAKHRVLPLMVLLGYLCP 894

Query: 664  LLIVGVSAAIY--SKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQK 721
            L + GV+  +Y     Y R   CWLD + G L++F+GPV  II  N ++    + KL + 
Sbjct: 895  LGLAGVTLGLYLPQGQYLREGECWLDGKGGALYTFVGPVLAIIGVNGLVLAMAMLKLLRP 954

Query: 722  FSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLF-IFDDRSLVLTYVFTILNCLQGA 780
                 P  +K +    +    +    + G TW  GL  + ++ S V  Y+FTILN LQG 
Sbjct: 955  SLSEGPPAEKRQALLGVIKALLILTPIFGLTWGLGLATLLEEVSTVPHYIFTILNTLQGV 1014

Query: 781  FLYLLHCLLNKKVREEYRKWAC 802
            F+ L  CL+++K++E  RK  C
Sbjct: 1015 FILLFGCLMDRKIQEALRKRFC 1036


>gi|223556014 G-protein coupled receptor 113 isoform 2 [Homo
           sapiens]
          Length = 997

 Score =  159 bits (402), Expect = 1e-38
 Identities = 106/322 (32%), Positives = 160/322 (49%), Gaps = 14/322 (4%)

Query: 495 CAFWKSDSDRG-GHWATEGCQV-LGSKNGSTTCQCSHLSSFAILMAHYDV-EDWKLTLIT 551
           C FW     +G G W+ EGCQ  + S + +  C C HL++F++LM+ + V E+  L L+T
Sbjct: 646 CVFWDHSLFQGRGGWSKEGCQAQVASASPTAQCLCQHLTAFSVLMSPHTVPEEPALALLT 705

Query: 552 RVGLALSLFCLLLCILTFLLV------RPIQGSRTTIHLHLCICLFVGSTIFLAGIENEG 605
           +VGL  S+  LL+C+  + LV        I   R    L++  CL    T FL       
Sbjct: 706 QVGLGASILALLVCLGVYWLVWRVVVRNKISYFRHAALLNMVFCLLAADTCFLGAPFLSP 765

Query: 606 GQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQ--GQGLSTRWLCLIGYGVP 663
           G     C   A L H+ +LA F WM  + L L   ++ VF    +      + L+GY  P
Sbjct: 766 GPRSPLCLAAAFLCHFLYLATFFWMLAQALVLAHQLLFVFHQLAKHRVLPLMVLLGYLCP 825

Query: 664 LLIVGVSAAIY--SKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQK 721
           L + GV+  +Y     Y R   CWLD + G L++F+GPV  II  N ++    + KL + 
Sbjct: 826 LGLAGVTLGLYLPQGQYLREGECWLDGKGGALYTFVGPVLAIIGVNGLVLAMAMLKLLRP 885

Query: 722 FSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLF-IFDDRSLVLTYVFTILNCLQGA 780
                P  +K +    +    +    + G TW  GL  + ++ S V  Y+FTILN LQG 
Sbjct: 886 SLSEGPPAEKRQALLGVIKALLILTPIFGLTWGLGLATLLEEVSTVPHYIFTILNTLQGV 945

Query: 781 FLYLLHCLLNKKVREEYRKWAC 802
           F+ L  CL+++K++E  RK  C
Sbjct: 946 FILLFGCLMDRKIQEALRKRFC 967


>gi|141802362 G-protein coupled receptor 113 isoform 3 [Homo
           sapiens]
          Length = 873

 Score =  159 bits (402), Expect = 1e-38
 Identities = 106/322 (32%), Positives = 160/322 (49%), Gaps = 14/322 (4%)

Query: 495 CAFWKSDSDRG-GHWATEGCQV-LGSKNGSTTCQCSHLSSFAILMAHYDV-EDWKLTLIT 551
           C FW     +G G W+ EGCQ  + S + +  C C HL++F++LM+ + V E+  L L+T
Sbjct: 516 CVFWDHSLFQGRGGWSKEGCQAQVASASPTAQCLCQHLTAFSVLMSPHTVPEEPALALLT 575

Query: 552 RVGLALSLFCLLLCILTFLLV------RPIQGSRTTIHLHLCICLFVGSTIFLAGIENEG 605
           +VGL  S+  LL+C+  + LV        I   R    L++  CL    T FL       
Sbjct: 576 QVGLGASILALLVCLGVYWLVWRVVVRNKISYFRHAALLNMVFCLLAADTCFLGAPFLSP 635

Query: 606 GQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQ--GQGLSTRWLCLIGYGVP 663
           G     C   A L H+ +LA F WM  + L L   ++ VF    +      + L+GY  P
Sbjct: 636 GPRSPLCLAAAFLCHFLYLATFFWMLAQALVLAHQLLFVFHQLAKHRVLPLMVLLGYLCP 695

Query: 664 LLIVGVSAAIY--SKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQK 721
           L + GV+  +Y     Y R   CWLD + G L++F+GPV  II  N ++    + KL + 
Sbjct: 696 LGLAGVTLGLYLPQGQYLREGECWLDGKGGALYTFVGPVLAIIGVNGLVLAMAMLKLLRP 755

Query: 722 FSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLF-IFDDRSLVLTYVFTILNCLQGA 780
                P  +K +    +    +    + G TW  GL  + ++ S V  Y+FTILN LQG 
Sbjct: 756 SLSEGPPAEKRQALLGVIKALLILTPIFGLTWGLGLATLLEEVSTVPHYIFTILNTLQGV 815

Query: 781 FLYLLHCLLNKKVREEYRKWAC 802
           F+ L  CL+++K++E  RK  C
Sbjct: 816 FILLFGCLMDRKIQEALRKRFC 837


>gi|24430141 fibrillin 1 precursor [Homo sapiens]
          Length = 2871

 Score =  158 bits (399), Expect = 2e-38
 Identities = 89/219 (40%), Positives = 107/219 (48%), Gaps = 31/219 (14%)

Query: 27   ARWCPQNSSCVNATA---CRCNPGFSSFSEIITTPTET-CDDINECATPSKVSCGKFSDC 82
            A  CP N  CVN      C CNPG+ S      TP    C DI+EC+  +   C  F  C
Sbjct: 1163 AHLCP-NGRCVNLIGKYQCACNPGYHS------TPDRLFCVDIDECSIMNG-GCETF--C 1212

Query: 83   WNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTC 142
             N+EGSY+C C PG+  +          + +C D+DEC+ NP +C   G C N  G Y C
Sbjct: 1213 TNSEGSYECSCQPGFALMP--------DQRSCTDIDECEDNPNICDG-GQCTNIPGEYRC 1263

Query: 143  QCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGP 202
             C  GF    ED K C DVNEC    N C S T C N  GS+ C C  G+    G     
Sbjct: 1264 LCYDGF-MASEDMKTCVDVNECDLNPNICLSGT-CENTKGSFICHCDMGYSGKKGK---- 1317

Query: 203  NNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGW 241
              T C D++EC  G H C    VC NT GS+ C C PGW
Sbjct: 1318 --TGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGW 1354



 Score =  150 bits (379), Expect = 5e-36
 Identities = 81/205 (39%), Positives = 110/205 (53%), Gaps = 25/205 (12%)

Query: 37   VNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPG 96
            + +  CRC+ GF+  SE        C DI+EC     + CG+   C NT G ++C C  G
Sbjct: 1048 IGSFKCRCDSGFALDSE-----ERNCTDIDECRISPDL-CGR-GQCVNTPGDFECKCDEG 1100

Query: 97   YEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPK 156
            YE  SG    KN     C D+DECQ++P LC+  G C NT GSY C+C PG +  P +  
Sbjct: 1101 YE--SGFMMMKN-----CMDIDECQRDPLLCRG-GVCHNTEGSYRCECPPGHQLSP-NIS 1151

Query: 157  VCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSG 216
             C D+NEC    + C +   C+N +G YQC C PG+       + P+   C D+DECS  
Sbjct: 1152 ACIDINECELSAHLCPNG-RCVNLIGKYQCACNPGYH------STPDRLFCVDIDECSIM 1204

Query: 217  QHQCDSSTVCFNTVGSYSCRCRPGW 241
               C+  T C N+ GSY C C+PG+
Sbjct: 1205 NGGCE--TFCTNSEGSYECSCQPGF 1227



 Score =  147 bits (372), Expect = 3e-35
 Identities = 77/217 (35%), Positives = 102/217 (47%), Gaps = 28/217 (12%)

Query: 25   GCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWN 84
            GC  +C  +        C C PGF+   +       +C DI+EC     +  G    C N
Sbjct: 1207 GCETFCTNSEGSYE---CSCQPGFALMPD-----QRSCTDIDECEDNPNICDG--GQCTN 1256

Query: 85   TEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQC 144
              G Y C+C  G+          +E   TC DV+EC  NP +C S GTC NT GS+ C C
Sbjct: 1257 IPGEYRCLCYDGF--------MASEDMKTCVDVNECDLNPNICLS-GTCENTKGSFICHC 1307

Query: 145  LPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNN 204
              G+    +    CTD+NEC  G + C     C N  GS++C C PGW          + 
Sbjct: 1308 DMGYSG-KKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIG--------DG 1358

Query: 205  TVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGW 241
              C D+DECS+G H C     C NT+GSY C C+ G+
Sbjct: 1359 IKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGY 1395



 Score =  130 bits (327), Expect = 5e-30
 Identities = 80/234 (34%), Positives = 118/234 (50%), Gaps = 41/234 (17%)

Query: 30   CPQNSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINECAT-PSKVSCGKFSDCWNT 85
            C +N+ C+N      C C PG+        T T  C+D NEC   P+  S G+   C +T
Sbjct: 1818 CQRNAECINTAGSYRCDCKPGYRF------TSTGQCNDRNECQEIPNICSHGQ---CIDT 1868

Query: 86   EGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCL 145
             GS+ C+C  G++         N+ +  C D++EC+++   C + GTC NT+GS+ C+C 
Sbjct: 1869 VGSFYCLCHTGFKT--------NDDQTMCLDINECERDA--CGN-GTCRNTIGSFNCRCN 1917

Query: 146  PGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNT 205
             GF  I      C DV+EC SG      +  C+N VGS+QC+C  G++        P+  
Sbjct: 1918 HGF--ILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEV------APDGR 1969

Query: 206  VCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDM 259
             C D++EC     +C   T C N  GSY C C PG+  +     N+K   CED+
Sbjct: 1970 TCVDINECLLEPRKCAPGT-CQNLDGSYRCICPPGYSLQ-----NEK---CEDI 2014



 Score =  124 bits (311), Expect = 4e-28
 Identities = 73/214 (34%), Positives = 104/214 (48%), Gaps = 33/214 (15%)

Query: 32   QNSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGS 88
            ++  C+N      C C  G+      I    E C D +EC+  +   CG    C N  G 
Sbjct: 2138 KHGQCINTDGSYRCECPFGY------ILAGNE-CVDTDECSVGNP--CGN-GTCKNVIGG 2187

Query: 89   YDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGF 148
            ++C C  G+EP             TC+D++EC QNP LC     CVNT GSY C+C  G+
Sbjct: 2188 FECTCEEGFEP---------GPMMTCEDINECAQNPLLCAF--RCVNTYGSYECKCPVGY 2236

Query: 149  KFIPEDPKVCTDVNECTSGQNPC-HSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVC 207
              + ED ++C D +EC  G++ C      C N +G+Y C C PG+Q        P+   C
Sbjct: 2237 -VLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQ------RRPDGEGC 2289

Query: 208  EDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGW 241
             D +EC +    C++   C NT GSY+C C  G+
Sbjct: 2290 VDENECQTKPGICENGR-CLNTRGSYTCECNDGF 2322



 Score =  122 bits (305), Expect = 2e-27
 Identities = 75/216 (34%), Positives = 106/216 (49%), Gaps = 33/216 (15%)

Query: 28  RWCPQNSSCV---NATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWN 84
           R+  QN  C+    +  C CN GF             C D++EC    K  C    +C N
Sbjct: 457 RYLCQNGRCIPTPGSCRCECNKGFQ------LDLRGECIDVDEC---EKNPCAG-GECIN 506

Query: 85  TEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQC 144
            +GSY C C  GY+           +   C+D+DEC QN R+C + G C+NT GS+ C C
Sbjct: 507 NQGSYTCQCRAGYQ--------STLTRTECRDIDECLQNGRICNN-GRCINTDGSFHCVC 557

Query: 145 LPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNN 204
             GF  +  D K C D++EC S +N C +   C+N  GS++C C+PG+Q         + 
Sbjct: 558 NAGF-HVTRDGKNCEDMDEC-SIRNMCLNGM-CINEDGSFKCICKPGFQ------LASDG 608

Query: 205 TVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPG 240
             C+D++EC +     +    C NT GSY C C PG
Sbjct: 609 RYCKDINECETPGICMNGR--CVNTDGSYRCECFPG 642



 Score =  119 bits (297), Expect = 2e-26
 Identities = 76/217 (35%), Positives = 105/217 (48%), Gaps = 29/217 (13%)

Query: 30   CPQNSSCVNATACRCN-PGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGS 88
            CP  S+   AT C    PGF     +I   T    DI+EC     V   +   C N  GS
Sbjct: 1736 CPIPSTDEFATLCGSQRPGF-----VIDIYTGLPVDIDECREIPGVC--ENGVCINMVGS 1788

Query: 89   YDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGF 148
            + C C  G+        F N+    C+D+DECQ  P +C+    C+NT GSY C C PG+
Sbjct: 1789 FRCECPVGF--------FYNDKLLVCEDIDECQNGP-VCQRNAECINTAGSYRCDCKPGY 1839

Query: 149  KFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCE 208
            +F       C D NEC    N C S   C++ VGS+ C C  G++         + T+C 
Sbjct: 1840 RFTSTGQ--CNDRNECQEIPNIC-SHGQCIDTVGSFYCLCHTGFK------TNDDQTMCL 1890

Query: 209  DVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRH 245
            D++EC   +  C + T C NT+GS++CRC  G+   H
Sbjct: 1891 DINECE--RDACGNGT-CRNTIGSFNCRCNHGFILSH 1924



 Score =  114 bits (284), Expect = 5e-25
 Identities = 73/217 (33%), Positives = 101/217 (46%), Gaps = 35/217 (16%)

Query: 30   CPQNSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTE 86
            C +++ C N      C C+PG+             C D++EC+  + + C + +DC NT 
Sbjct: 1333 CGKHAVCTNTAGSFKCSCSPGWIGDGI-------KCTDLDECSNGTHM-CSQHADCKNTM 1384

Query: 87   GSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLP 146
            GSY C+C  GY               TC D+DEC +N  LC + G C+N  G Y C+C  
Sbjct: 1385 GSYRCLCKEGY----------TGDGFTCTDLDECSENLNLCGN-GQCLNAPGGYRCECDM 1433

Query: 147  GFKFIPE-DPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNT 205
            G  F+P  D K C D++EC S  N C   T C N  G ++C C  G++      N  +  
Sbjct: 1434 G--FVPSADGKACEDIDEC-SLPNICVFGT-CHNLPGLFRCECEIGYELDRSGGNCTDVN 1489

Query: 206  VCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWK 242
             C D   C SG         C NT GSY C C P ++
Sbjct: 1490 ECLDPTTCISGN--------CVNTPGSYICDCPPDFE 1518



 Score =  113 bits (282), Expect = 8e-25
 Identities = 74/209 (35%), Positives = 100/209 (47%), Gaps = 33/209 (15%)

Query: 36   CVNATA---CRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDCV 92
            CVN      C+C PGF       T    +C D NEC +   + CG    C NT GS+ C 
Sbjct: 2500 CVNTIGGFTCKCPPGF-------TQHHTSCIDNNECTSDINL-CGSKGICQNTPGSFTCE 2551

Query: 93   CSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIP 152
            C  G+          +++ ++C+DVDEC+ N R    +G C N +G Y C C  G+    
Sbjct: 2552 CQRGFS--------LDQTGSSCEDVDECEGNHRC--QHG-CQNIIGGYRCSCPQGY-LQH 2599

Query: 153  EDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDE 212
                 C D NEC S  + C  ++ C N +GSY+C C  G+Q    S        C+D++E
Sbjct: 2600 YQWNQCVDENECLSA-HICGGAS-CHNTLGSYKCMCPAGFQYEQFSGG------CQDINE 2651

Query: 213  CSSGQHQCDSSTVCFNTVGSYSCRCRPGW 241
            C S Q  C  S  C NT G Y C C PG+
Sbjct: 2652 CGSAQAPC--SYGCSNTEGGYLCGCPPGY 2678



 Score =  108 bits (269), Expect = 3e-23
 Identities = 71/215 (33%), Positives = 98/215 (45%), Gaps = 33/215 (15%)

Query: 31   PQNSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEG 87
            P N  C N      C C  G+     I+     +C D++ECAT    +C     C NT G
Sbjct: 2454 PCNFICKNTEGSYQCSCPKGY-----ILQEDGRSCKDLDECATKQH-NCQFL--CVNTIG 2505

Query: 88   SYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPG 147
             + C C PG+           +   +C D +EC  +  LC S G C NT GS+TC+C  G
Sbjct: 2506 GFTCKCPPGF----------TQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRG 2555

Query: 148  FKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVC 207
            F  + +    C DV+EC  G + C     C N +G Y+C C  G+              C
Sbjct: 2556 FS-LDQTGSSCEDVDEC-EGNHRCQHG--CQNIIGGYRCSCPQGYL------QHYQWNQC 2605

Query: 208  EDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWK 242
             D +EC S  H C  ++ C NT+GSY C C  G++
Sbjct: 2606 VDENECLSA-HICGGAS-CHNTLGSYKCMCPAGFQ 2638



 Score =  103 bits (258), Expect = 5e-22
 Identities = 71/243 (29%), Positives = 99/243 (40%), Gaps = 52/243 (21%)

Query: 32   QNSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGS 88
            Q   C+N      CRC  G+      +   T  CDD+NEC TP    CG    C+NT G+
Sbjct: 1618 QGGKCINTFGSFQCRCPTGY-----YLNEDTRVCDDVNECETPG--ICGP-GTCYNTVGN 1669

Query: 89   YDCVCSPGYEPVSGAKTFKNESENTC-----QDVDECQQNP--RLCKSYGTCVNTLG--- 138
            Y C+C P Y  V+G     +   + C      D   C       + K    C   +G   
Sbjct: 1670 YTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAW 1729

Query: 139  SYTCQCLPGFKFIPEDPKVCT-------------------DVNECTSGQNPCHSSTHCLN 179
            +  C+  P    IP   +  T                   D++EC      C +   C+N
Sbjct: 1730 NKPCEQCP----IPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGV-CIN 1784

Query: 180  NVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRP 239
             VGS++C C  G+             VCED+DEC +G   C  +  C NT GSY C C+P
Sbjct: 1785 MVGSFRCECPVGFF------YNDKLLVCEDIDECQNGP-VCQRNAECINTAGSYRCDCKP 1837

Query: 240  GWK 242
            G++
Sbjct: 1838 GYR 1840



 Score =  101 bits (251), Expect = 3e-21
 Identities = 75/250 (30%), Positives = 107/250 (42%), Gaps = 75/250 (30%)

Query: 32   QNSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINECAT-PSKVSCGKFSDCWNTEG 87
            +N  C+N      C+CN G+      +     TC DINEC   P K + G    C N +G
Sbjct: 1943 RNGQCINTVGSFQCQCNEGYE-----VAPDGRTCVDINECLLEPRKCAPGT---CQNLDG 1994

Query: 88   SYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPG 147
            SY C+C PGY       + +NE    C+D+DEC + P +C + GTC NT GS+ C C  G
Sbjct: 1995 SYRCICPPGY-------SLQNEK---CEDIDECVEEPEIC-ALGTCSNTEGSFKCLCPEG 2043

Query: 148  FKFIPEDPKVCTDV-----------NECTSGQNPCHSSTHCLNNVGSYQCRCR-PGW--- 192
            F  +    + C D+            +C+S ++  HS   C        C  +  GW   
Sbjct: 2044 FS-LSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECC-------CALKGEGWGDP 2095

Query: 193  -QPIPGSPN---------------GPNNTV-----CEDVDECSSGQHQCDSSTVCFNTVG 231
             +  P  P+               GP+++      C++ D C  GQ        C NT G
Sbjct: 2096 CELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQ--------CINTDG 2147

Query: 232  SYSCRCRPGW 241
            SY C C  G+
Sbjct: 2148 SYRCECPFGY 2157



 Score =  100 bits (250), Expect = 4e-21
 Identities = 74/246 (30%), Positives = 106/246 (43%), Gaps = 47/246 (19%)

Query: 32   QNSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINECATPSKV---SCGKFSDCWNT 85
            +N  C+N      C CN GF++     +   + C D  E    ++V    C   S   N 
Sbjct: 2303 ENGRCLNTRGSYTCECNDGFTA-----SPNQDECLDNREGYCFTEVLQNMCQIGSSNRNP 2357

Query: 86   EGSYDCVCSPGYE--------PVSGAKTFKNESEN------TCQDVDECQQNPRLCKSYG 131
                +C C  G          P  G   FK    +         D+DEC+    +C++ G
Sbjct: 2358 VTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRN-G 2416

Query: 132  TCVNTLGSYTCQCLPGFKFIPEDPKV----CTDVNECTSGQNPCHSSTHCLNNVGSYQCR 187
             CVN  GSY C C  G+      P +    C D+NEC     PC+    C N  GSYQC 
Sbjct: 2417 ECVNDRGSYHCICKTGYT-----PDITGTSCVDLNECNQAPKPCNFI--CKNTEGSYQCS 2469

Query: 188  CRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHG- 246
            C  G+          +   C+D+DEC++ QH C    +C NT+G ++C+C PG+   H  
Sbjct: 2470 CPKGYIL------QEDGRSCKDLDECATKQHNCQF--LCVNTIGGFTCKCPPGFTQHHTS 2521

Query: 247  -IPNNQ 251
             I NN+
Sbjct: 2522 CIDNNE 2527



 Score =  100 bits (248), Expect = 7e-21
 Identities = 72/255 (28%), Positives = 108/255 (42%), Gaps = 47/255 (18%)

Query: 14  TLPGAETQDSRGC---ARWCPQNSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINE 67
           TL   E +D   C    R C  N  C+N      C CN GF      +T   + C+D++E
Sbjct: 522 TLTRTECRDIDECLQNGRIC-NNGRCINTDGSFHCVCNAGFH-----VTRDGKNCEDMDE 575

Query: 68  CATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLC 127
           C+  +    G    C N +GS+ C+C PG++  S  +         C+D++EC+  P +C
Sbjct: 576 CSIRNMCLNGM---CINEDGSFKCICKPGFQLASDGRY--------CKDINECE-TPGIC 623

Query: 128 KSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDV---NECTSGQNPCHSSTHCLNNVGSY 184
            + G CVNT GSY C+C PG   +  D +VC D    + C  G             V   
Sbjct: 624 MN-GRCVNTDGSYRCECFPGLA-VGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKS 681

Query: 185 QCRCR-------PGWQPIPGSPNGPNNTVC----------EDVDECSSGQHQCDSSTVCF 227
           +C C           QP P   +     +C           D++EC+     C +  +C 
Sbjct: 682 ECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNG-ICE 740

Query: 228 NTVGSYSCRCRPGWK 242
           N  G+Y C C  G++
Sbjct: 741 NLRGTYKCICNSGYE 755



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 57/161 (35%), Positives = 82/161 (50%), Gaps = 22/161 (13%)

Query: 82  CWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYT 141
           C  T GS  C C+ G         F+ +    C DVDEC++NP  C   G C+N  GSYT
Sbjct: 465 CIPTPGSCRCECNKG---------FQLDLRGECIDVDECEKNP--CAG-GECINNQGSYT 512

Query: 142 CQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNG 201
           CQC  G++      + C D++EC      C++   C+N  GS+ C C  G+       N 
Sbjct: 513 CQCRAGYQSTLTRTE-CRDIDECLQNGRICNNG-RCINTDGSFHCVCNAGFHVTRDGKN- 569

Query: 202 PNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWK 242
                CED+DECS  ++ C  + +C N  GS+ C C+PG++
Sbjct: 570 -----CEDMDECSI-RNMC-LNGMCINEDGSFKCICKPGFQ 603



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 80/267 (29%), Positives = 108/267 (40%), Gaps = 50/267 (18%)

Query: 30   CPQNS-----SCVNATA---CRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSD 81
            C QN       CVN      C+C  G+     ++      C D +EC         K  +
Sbjct: 2210 CAQNPLLCAFRCVNTYGSYECKCPVGY-----VLREDRRMCKDEDECEEGKHDCTEKQME 2264

Query: 82   CWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYT 141
            C N  G+Y C+C PGY+        +      C D +ECQ  P +C++ G C+NT GSYT
Sbjct: 2265 CKNLIGTYMCICGPGYQ--------RRPDGEGCVDENECQTKPGICEN-GRCLNTRGSYT 2315

Query: 142  CQCLPGFKFIPEDPKVCTDVNE--CTSG--QNPCHSSTHCLNNVGSYQCRC--RPGWQ-- 193
            C+C  GF   P   + C D  E  C +   QN C   +   N V   +C C    GW   
Sbjct: 2316 CECNDGFTASPNQDE-CLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPH 2374

Query: 194  ----PIPGS-------PNGPN-NTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGW 241
                P  G+       P+G    T   D+DEC      C +   C N  GSY C C+ G+
Sbjct: 2375 CEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGE-CVNDRGSYHCICKTGY 2433

Query: 242  KPRHGIPNNQKDTVCEDMTFSTWTPPP 268
             P      +   T C D+      P P
Sbjct: 2434 TP------DITGTSCVDLNECNQAPKP 2454



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 72/232 (31%), Positives = 102/232 (43%), Gaps = 33/232 (14%)

Query: 32   QNSSCVNATA---CRCNPGFSSFSE---IITTPTETCD---DINECATP------SKVSC 76
            +N  CVN      C+C  G +  +     +    ETC    +  EC  P          C
Sbjct: 922  KNGLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACC 981

Query: 77   GKFSDCWNTEGSYDCVC--SPGYE------PVSGAKTFKNESENTCQDVDECQQNPRLCK 128
                  W TE   +C    +P YE      P    K   N  +   +D++EC+  P LC 
Sbjct: 982  CSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITN-GKPFFKDINECKMIPSLC- 1039

Query: 129  SYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRC 188
            ++G C NT+GS+ C+C  GF    E+ + CTD++EC    + C     C+N  G ++C+C
Sbjct: 1040 THGKCRNTIGSFKCRCDSGFALDSEE-RNCTDIDECRISPDLC-GRGQCVNTPGDFECKC 1097

Query: 189  RPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPG 240
              G++   G     N   C D+DEC      C    VC NT GSY C C PG
Sbjct: 1098 DEGYE--SGFMMMKN---CMDIDECQRDPLLCRGG-VCHNTEGSYRCECPPG 1143



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 84/291 (28%), Positives = 116/291 (39%), Gaps = 87/291 (29%)

Query: 13  LTLPGAETQDSRGCA-RWCPQNSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINEC 68
           +T  G   +D   C+ R    N  C+N      C C PGF   S+        C DINEC
Sbjct: 563 VTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASD-----GRYCKDINEC 617

Query: 69  ATPSKVSCGKFSDCWNTEGSYDCVCSP----------------------GYE------PV 100
            TP     G+   C NT+GSY C C P                      GY+      P+
Sbjct: 618 ETPGICMNGR---CVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPL 674

Query: 101 SGAKTFKNE------------------SENTCQ----------------DVDECQQNPRL 126
            GA T K+E                  ++N+ +                D++EC  +P +
Sbjct: 675 FGAVT-KSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDI 733

Query: 127 CKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQC 186
           C + G C N  G+Y C C  G++ +    K C D+NEC      C +   C N  GS+ C
Sbjct: 734 CPN-GICENLRGTYKCICNSGYE-VDSTGKNCVDINECVLNSLLCDNG-QCRNTPGSFVC 790

Query: 187 RCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRC 237
            C  G+         P+   CED+DEC S    C +  VC N+ GS+ C C
Sbjct: 791 TCPKGFI------YKPDLKTCEDIDECESS--PCING-VCKNSPGSFICEC 832



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 77/268 (28%), Positives = 102/268 (38%), Gaps = 83/268 (30%)

Query: 30  CPQNSSCVNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSY 89
           CP  +S      C   PG +S             DINECA    +       C N  G+Y
Sbjct: 699 CPAQNSAEYQALCSSGPGMTSAGS----------DINECALDPDICPNGI--CENLRGTY 746

Query: 90  DCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFK 149
            C+C+ GYE  S  K         C D++EC  N  LC + G C NT GS+ C C  GF 
Sbjct: 747 KCICNSGYEVDSTGK--------NCVDINECVLNSLLCDN-GQCRNTPGSFVCTCPKGFI 797

Query: 150 FIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPG------------------ 191
           + P D K C D++EC S  +PC +   C N+ GS+ C C                     
Sbjct: 798 YKP-DLKTCEDIDECES--SPCINGV-CKNSPGSFICECSSESTLDPTKTICIETIKGTC 853

Query: 192 WQPI---------------------PGSPNGPNNTVC------------------EDVDE 212
           WQ +                      G+  G   T+C                  ED+DE
Sbjct: 854 WQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQCEDIDE 913

Query: 213 CSSGQHQCDSSTVCFNTVGSYSCRCRPG 240
           C      C +  +C NT GS+ C+C  G
Sbjct: 914 CEVFPGVCKNG-LCVNTRGSFKCQCPSG 940



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 81/259 (31%), Positives = 104/259 (40%), Gaps = 58/259 (22%)

Query: 33   NSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSY 89
            N  C+NA     C C+ GF     + +   + C+DI+EC+ P+      F  C N  G +
Sbjct: 1417 NGQCLNAPGGYRCECDMGF-----VPSADGKACEDIDECSLPNICV---FGTCHNLPGLF 1468

Query: 90   DCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFK 149
             C C  GYE         + S   C DV+EC  +P  C S G CVNT GSY C C P F+
Sbjct: 1469 RCECEIGYE--------LDRSGGNCTDVNECL-DPTTCIS-GNCVNTPGSYICDCPPDFE 1518

Query: 150  FIPEDPK-VCTDVNECTSGQNP--CHSSTHCLNNVG----SYQCRCRPG--WQP------ 194
              P     V T    C     P   +  T C N +G       C C  G  W        
Sbjct: 1519 LNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCP 1578

Query: 195  ----------IPGS----PNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPG 240
                       PG     PN P   + ED+DEC      C     C NT GS+ CRC  G
Sbjct: 1579 AVNTSEYKILCPGGEGFRPN-PITVILEDIDECQELPGLCQGGK-CINTFGSFQCRCPTG 1636

Query: 241  WKPRHGIPNNQKDTVCEDM 259
            +        N+   VC+D+
Sbjct: 1637 YY------LNEDTRVCDDV 1649



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 69/229 (30%), Positives = 91/229 (39%), Gaps = 21/229 (9%)

Query: 26  CARWCPQNSSCVNATACRCNPGFSSFS---EIITTPTETCDDINECATP-SKVSCGKFSD 81
           C   C     CV    C C  GF+      +  T P  T      C    S + C K + 
Sbjct: 150 CESGCLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTK-TL 208

Query: 82  CWNTEG---SYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLG 138
           C  T G    + C   P            N     CQDVDECQ  P LC+  G C+NT+G
Sbjct: 209 CCATVGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQG-GNCINTVG 267

Query: 139 SYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGS 198
           S+ C+C  G K + E  + C D++EC++    C     C N V SY C+C PG+      
Sbjct: 268 SFECKCPAGHK-LNEVSQKCEDIDECSTIPGICEGG-ECTNTVSSYFCKCPPGFY----- 320

Query: 199 PNGPNNTVCEDV--DECSSGQHQCDSSTVCFNTVGSYSCRCRPG--WKP 243
              P+ T C DV    C +       S     ++    C C  G  W P
Sbjct: 321 -TSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCCCDAGRCWSP 368



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 71/232 (30%), Positives = 94/232 (40%), Gaps = 54/232 (23%)

Query: 59   TETCDDINECAT-PSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDV 117
            T   +DI+EC   P     GK   C NT GS+ C C  GY        + NE    C DV
Sbjct: 1601 TVILEDIDECQELPGLCQGGK---CINTFGSFQCRCPTGY--------YLNEDTRVCDDV 1649

Query: 118  DECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHC 177
            +EC+  P +C   GTC NT+G+YTC C P +  +      C D+      +N    +  C
Sbjct: 1650 NECE-TPGICGP-GTCYNTVGNYTCICPPDYMQV-NGGNNCMDMRRSLCYRNYYADNQTC 1706

Query: 178  ----LNNVGSYQCRCR----PGWQ------PIPGSPNGPNNTVC---------------- 207
                L N+    C C       W       PIP +      T+C                
Sbjct: 1707 DGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFA--TLCGSQRPGFVIDIYTGLP 1764

Query: 208  EDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDM 259
             D+DEC      C++  VC N VGS+ C C  G+        N K  VCED+
Sbjct: 1765 VDIDECREIPGVCENG-VCINMVGSFRCECPVGFF------YNDKLLVCEDI 1809



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 70/263 (26%), Positives = 101/263 (38%), Gaps = 68/263 (25%)

Query: 32   QNSSCVNATACRCNPGF---SSFSEIITTPTET------------------CDDINECAT 70
            ++S C+N   C+ +PG       SE    PT+T                  C+     AT
Sbjct: 812  ESSPCINGV-CKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGAT 870

Query: 71   PSKVSCGKFSDCWN---TEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLC 127
                 C      W    T    D +C  GY  + G +         C+D+DEC+  P +C
Sbjct: 871  LKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQ---------CEDIDECEVFPGVC 921

Query: 128  KSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVN-----------ECTSGQNPCHSSTH 176
            K+ G CVNT GS+ CQC  G   +    ++C D+            ECT      H    
Sbjct: 922  KN-GLCVNTRGSFKCQCPSGMT-LDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDA 979

Query: 177  CLNNVGSY-------QCRCR--PGWQPIPGSPNGPNNTVCE---------DVDECSSGQH 218
            C  +VG+        +C  R  P ++ +   P GP     E         D++EC     
Sbjct: 980  CCCSVGAAWGTEECEECPMRNTPEYEEL--CPRGPGFATKEITNGKPFFKDINECKMIPS 1037

Query: 219  QCDSSTVCFNTVGSYSCRCRPGW 241
             C     C NT+GS+ CRC  G+
Sbjct: 1038 LCTHGK-CRNTIGSFKCRCDSGF 1059



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 66/244 (27%), Positives = 97/244 (39%), Gaps = 47/244 (19%)

Query: 22   DSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSD 81
            + R CA    QN     +  C C PG+S          E C+DI+EC    ++       
Sbjct: 1980 EPRKCAPGTCQNLD--GSYRCICPPGYS-------LQNEKCEDIDECVEEPEICA--LGT 2028

Query: 82   CWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQ---DVDECQQNPRLCKSYGTCVNTLG 138
            C NTEGS+ C+C  G+   S  +  ++   + C    +  +C        S   C   L 
Sbjct: 2029 CSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALK 2088

Query: 139  SY----TCQCLP---------------GFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLN 179
                   C+  P               G    P+D  V  D++EC       H    C+N
Sbjct: 2089 GEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAV--DMDECKEPDVCKHGQ--CIN 2144

Query: 180  NVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRP 239
              GSY+C C  G+  + G+        C D DECS G + C + T C N +G + C C  
Sbjct: 2145 TDGSYRCECPFGYI-LAGNE-------CVDTDECSVG-NPCGNGT-CKNVIGGFECTCEE 2194

Query: 240  GWKP 243
            G++P
Sbjct: 2195 GFEP 2198



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 62/235 (26%), Positives = 88/235 (37%), Gaps = 33/235 (14%)

Query: 16  PGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVS 75
           P   ++  + C   C    SC +   C C  G+             C +   C  P++ +
Sbjct: 109 PSCGSRSIQHCNIRCMNGGSCSD-DHCLCQKGYIGTHCGQPVCESGCLNGGRCVAPNRCA 167

Query: 76  CGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTC-- 133
           C        T G     C   Y        F   S   CQ     Q +  +C     C  
Sbjct: 168 C--------TYGFTGPQCERDYRT---GPCFTVISNQMCQG----QLSGIVCTKTLCCAT 212

Query: 134 VNTLGSYTCQCLPGFK------FIPE-DPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQC 186
           V     + C+  P         FIP      C DV+EC +    C    +C+N VGS++C
Sbjct: 213 VGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGG-NCINTVGSFEC 271

Query: 187 RCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGW 241
           +C  G +    S        CED+DECS+    C+    C NTV SY C+C PG+
Sbjct: 272 KCPAGHKLNEVSQK------CEDIDECSTIPGICEGGE-CTNTVSSYFCKCPPGF 319



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 58/207 (28%), Positives = 78/207 (37%), Gaps = 38/207 (18%)

Query: 62   CDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTC---QDVD 118
            C+DI+EC     V   K   C NT GS+ C C  G    +  +   +    TC    + +
Sbjct: 908  CEDIDECEVFPGVC--KNGLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDE 965

Query: 119  EC-------QQNPRLCKSYGTCVNTLGSYTCQCL------------PGF--KFIPEDPKV 157
            EC        +    C S G    T     C               PGF  K I      
Sbjct: 966  ECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPF 1025

Query: 158  CTDVNECTSGQNPCHSSTH--CLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSS 215
              D+NEC    + C   TH  C N +GS++CRC  G+       N      C D+DEC  
Sbjct: 1026 FKDINECKMIPSLC---THGKCRNTIGSFKCRCDSGFALDSEERN------CTDIDECRI 1076

Query: 216  GQHQCDSSTVCFNTVGSYSCRCRPGWK 242
                C     C NT G + C+C  G++
Sbjct: 1077 SPDLCGRGQ-CVNTPGDFECKCDEGYE 1102



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 80/303 (26%), Positives = 107/303 (35%), Gaps = 72/303 (23%)

Query: 3   GRVFLAFCV--WLTLPGAETQDSRGCARWCPQNSSCVNATACR--CNPGFSSFSEIITTP 58
           G  + A+C   W TLPG                + C+    CR  C  GF S   + T P
Sbjct: 60  GSRYNAYCCPGWKTLPGG---------------NQCI-VPICRHSCGDGFCSRPNMCTCP 103

Query: 59  TETCDDINECATPSKVSCGKFSDCWNTEGSYD--CVCSPGYEPVSGAKTFKNESENTCQD 116
           +        C + S   C     C N     D  C+C  GY    G    +   E+ C +
Sbjct: 104 SGQIAP--SCGSRSIQHCN--IRCMNGGSCSDDHCLCQKGY---IGTHCGQPVCESGCLN 156

Query: 117 VDECQQNPRLCKSYG-------------TCVNTLGSYTCQC-LPGFKFIPEDPKVCTDVN 162
              C    R   +YG              C   + +  CQ  L G         VCT   
Sbjct: 157 GGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGI--------VCTKTL 208

Query: 163 EC-TSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCD 221
            C T G+   H    C     +    CR G+  IP    G     C+DVDEC +    C 
Sbjct: 209 CCATVGRAWGHPCEMC----PAQPHPCRRGF--IPNIRTG----ACQDVDECQAIPGLCQ 258

Query: 222 SSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTP---PPGVHSQTLSRF 278
               C NTVGS+ C+C  G K       N+    CED+   +  P     G  + T+S +
Sbjct: 259 GGN-CINTVGSFECKCPAGHK------LNEVSQKCEDIDECSTIPGICEGGECTNTVSSY 311

Query: 279 FDK 281
           F K
Sbjct: 312 FCK 314


>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
            sapiens]
          Length = 3312

 Score =  158 bits (399), Expect = 2e-38
 Identities = 109/389 (28%), Positives = 183/389 (47%), Gaps = 40/389 (10%)

Query: 430  YESSIRGVQLRRLSAVNS------IFLSHNNTKE-LNSPILFAFSHLESSDGEAGRDPPA 482
            +++  RG +L +   +NS      +F   N  +  L SPI   F  L++++         
Sbjct: 2424 FQAERRGARLPQNPVMNSPVVSVAVFHGRNFLRGILESPISLEFRLLQTAN--------- 2474

Query: 483  KDVMPGPRQELLCAFWKSD--SDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHY 540
                   R + +C  W     +++ G W    C+++        C+CS   +F +LM   
Sbjct: 2475 -------RSKAICVQWDPPGLAEQHGVWTARDCELVHRNGSHARCRCSRTGTFGVLMDAS 2527

Query: 541  DVEDWK-----LTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGST 595
              E  +     L + T V +A+S+  L+L     L +R ++ +   IH ++   L V   
Sbjct: 2528 PRERLEGDLELLAVFTHVVVAVSVAALVLTAAILLSLRSLKSNVRGIHANVAAALGVAEL 2587

Query: 596  IFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWL 655
            +FL GI     Q  L C  VA LLHY FL+ F W+ ++GL LY + V        + R+ 
Sbjct: 2588 LFLLGIHRTHNQ--LVCTAVAILLHYFFLSTFAWLFVQGLHLYRMQVEPRNVDRGAMRFY 2645

Query: 656  CLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTV 715
              +G+GVP +++G++  +  +GYG P +CW+   +  +WSF GPV  +I+ N  +F    
Sbjct: 2646 HALGWGVPAVLLGLAVGLDPEGYGNPDFCWISVHEPLIWSFAGPVVLVIVMNGTMF---- 2701

Query: 716  WKLTQKFSEINPDMKKLKKARALTI-TAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTIL 774
              L    +  +   ++ KK  ALT+ ++   L L+  +W+FGL   +   L   Y+   L
Sbjct: 2702 --LLAARTSCSTGQREAKKTSALTLRSSFLLLLLVSASWLFGLLAVNHSILAFHYLHAGL 2759

Query: 775  NCLQGAFLYLLHCLLNKKVREEYRKWACL 803
              LQG  + LL C+LN   R  +   ACL
Sbjct: 2760 CGLQGLAVLLLFCVLNADARAAWMP-ACL 2787



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 33/114 (28%), Positives = 51/114 (44%), Gaps = 25/114 (21%)

Query: 91   CVCSPGYEPVSGAKTFKNESENTCQ-DVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFK 149
            C C PG+            + + C+ ++D C  NP  C++ G C    G YTC C P  +
Sbjct: 1421 CRCPPGF------------TGDFCETELDLCYSNP--CRNGGACARREGGYTCVCRP--R 1464

Query: 150  FIPEDPKVCTDVNECTSGQNPCHSSTHCLNNV-GSYQCRCRPGWQPIPGSPNGP 202
            F  ED ++ T+   C  G   C +   C +   G ++C+C     P  G+  GP
Sbjct: 1465 FTGEDCELDTEAGRCVPG--VCRNGGTCTDAPNGGFRCQC-----PAGGAFEGP 1511



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 31/110 (28%), Positives = 44/110 (40%), Gaps = 23/110 (20%)

Query: 42   CRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVS 101
            CRC PGF+   +   T  + C      + P    C     C   EG Y CVC P +    
Sbjct: 1421 CRCPPGFTG--DFCETELDLC-----YSNP----CRNGGACARREGGYTCVCRPRF---- 1465

Query: 102  GAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNT-LGSYTCQCLPGFKF 150
                     E+   D +  +  P +C++ GTC +   G + CQC  G  F
Sbjct: 1466 -------TGEDCELDTEAGRCVPGVCRNGGTCTDAPNGGFRCQCPAGGAF 1508



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 48/195 (24%), Positives = 69/195 (35%), Gaps = 53/195 (27%)

Query: 62   CDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQ 121
            C   N CA+     C   +DC +   ++ C C PGY                C  VD C 
Sbjct: 1944 CVVTNACASGP---CPPHADCRDLWQTFSCTCQPGYYGPG------------C--VDACL 1986

Query: 122  QNPRLCKSYGTCVNTLGS---YTCQCLPGF-------KFIPEDPKVCTDVNECTSGQNPC 171
             NP  C++ G+C +  G+   YTC C+ G+       +   + P+       C     PC
Sbjct: 1987 LNP--CQNQGSCRHLPGAPHGYTCDCVGGYFGHHCEHRMDQQCPRGWWGSPTC----GPC 2040

Query: 172  HSSTH------CLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTV 225
            +   H      C  N  + QC C+         P G ++ +  D     S    C     
Sbjct: 2041 NCDVHKGFDPNC--NKTNGQCHCK----EFHYRPRGSDSCLPCDCYPVGSTSRSC----- 2089

Query: 226  CFNTVGSYSCRCRPG 240
                  S  C CRPG
Sbjct: 2090 ---APHSGQCPCRPG 2101



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 28/109 (25%), Positives = 43/109 (39%), Gaps = 18/109 (16%)

Query: 134  VNTLGSYTCQCLPGFKFIPEDPKVC-TDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGW 192
            +  +    C+C PGF         C T+++ C S  NPC +   C    G Y C CRP +
Sbjct: 1413 IQPIAGLRCRCPPGFT-----GDFCETELDLCYS--NPCRNGGACARREGGYTCVCRPRF 1465

Query: 193  QPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTV-GSYSCRCRPG 240
                    G +  +  +   C  G   C +   C +   G + C+C  G
Sbjct: 1466 -------TGEDCELDTEAGRCVPG--VCRNGGTCTDAPNGGFRCQCPAG 1505


>gi|119943125 G protein-coupled receptor 64 isoform 3 [Homo sapiens]
          Length = 995

 Score =  154 bits (390), Expect = 2e-37
 Identities = 146/584 (25%), Positives = 248/584 (42%), Gaps = 72/584 (12%)

Query: 254 TVCEDMTFSTWTPPPG----VHSQTLSRFFDKVQDLGRDSKTSSAEVTIQN-VIKLVDEL 308
           TV      +T + PP     V++ ++S   ++V  + +     S E  +   +I  V  L
Sbjct: 327 TVSAPANVNTTSAPPVQTDIVNTSSISDLENQVLQMEKALSLGSLEPNLAGEMINQVSRL 386

Query: 309 MEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTELTLMIQERG 368
           + +P D+  LAP     +A +LL  ++DI   L  S      T IS ++  L L +    
Sbjct: 387 LHSPPDM--LAP-----LAQRLLKVVDDIGLQLNFSN-----TTISLTSPSLALAVIRVN 434

Query: 369 DKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLNLHSKKQAELEE 428
             +       A+   N  V+   + P  ++  I    ++   L    + L S+ Q    E
Sbjct: 435 ASSFNTTTFVAQDPANLQVSLETQAPENSIGTITLPSSLMNNLPAHDMELASRVQFNFFE 494

Query: 429 ----IYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDPPAKD 484
                 + S+  + L  +S V S  +++   + L   +     H+  S  E         
Sbjct: 495 TPALFQDPSLENLSL--ISYVISSSVANLTVRNLTRNVTVTLKHINPSQDEL-------- 544

Query: 485 VMPGPRQELLCAFWKSDSDRG-GHWATEGCQVLGSKNGSTTCQCSHLSSFAILM-----A 538
                   + C FW    + G G W+  GC V   +   T C CSHL+SF +L+     +
Sbjct: 545 -------TVRCVFWDLGRNGGRGGWSDNGCSVKDRRLNETICTCSHLTSFGVLLDLSRTS 597

Query: 539 HYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTT-IHLHLCICLFVGSTIF 597
               +   LT IT +G  LS   L + ++T++    I+    + I + LC  L + + +F
Sbjct: 598 VLPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVF 657

Query: 598 LAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLS-TRWLC 656
           L        ++   C  VA  LHY  L +F WM LE   +Y  +V+VF           C
Sbjct: 658 LLDSWIALYKMQGLCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFC 717

Query: 657 LIGYGVPLLIVGVSAAIYSKGYGRPRY-----------CWLDFEQGFLWSFLGPVTFIIL 705
           ++G+GVP ++V +   I    YG   Y           CW++    F  + +G    I L
Sbjct: 718 IVGWGVPAVVVTIILTISPDNYGLGSYGKFPNGSPDDFCWINNNAVFYITVVGYFCVIFL 777

Query: 706 CNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQL-------FLLGCTWVFGLF 758
            N  +F+  + +L +        +KK K+  A   T+I  L       FLLG TW F  F
Sbjct: 778 LNVSMFIVVLVQLCR--------IKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFF 829

Query: 759 IFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWAC 802
            +   ++   Y+F I N LQG F+++ +C+  + VR+++R++ C
Sbjct: 830 AWGPVNVTFMYLFAIFNTLQGFFIFIFYCVAKENVRKQWRRYLC 873


>gi|119943116 G protein-coupled receptor 64 isoform 2 [Homo sapiens]
          Length = 1003

 Score =  154 bits (390), Expect = 2e-37
 Identities = 146/584 (25%), Positives = 248/584 (42%), Gaps = 72/584 (12%)

Query: 254 TVCEDMTFSTWTPPPG----VHSQTLSRFFDKVQDLGRDSKTSSAEVTIQN-VIKLVDEL 308
           TV      +T + PP     V++ ++S   ++V  + +     S E  +   +I  V  L
Sbjct: 335 TVSAPANVNTTSAPPVQTDIVNTSSISDLENQVLQMEKALSLGSLEPNLAGEMINQVSRL 394

Query: 309 MEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTELTLMIQERG 368
           + +P D+  LAP     +A +LL  ++DI   L  S      T IS ++  L L +    
Sbjct: 395 LHSPPDM--LAP-----LAQRLLKVVDDIGLQLNFSN-----TTISLTSPSLALAVIRVN 442

Query: 369 DKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLNLHSKKQAELEE 428
             +       A+   N  V+   + P  ++  I    ++   L    + L S+ Q    E
Sbjct: 443 ASSFNTTTFVAQDPANLQVSLETQAPENSIGTITLPSSLMNNLPAHDMELASRVQFNFFE 502

Query: 429 ----IYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDPPAKD 484
                 + S+  + L  +S V S  +++   + L   +     H+  S  E         
Sbjct: 503 TPALFQDPSLENLSL--ISYVISSSVANLTVRNLTRNVTVTLKHINPSQDEL-------- 552

Query: 485 VMPGPRQELLCAFWKSDSDRG-GHWATEGCQVLGSKNGSTTCQCSHLSSFAILM-----A 538
                   + C FW    + G G W+  GC V   +   T C CSHL+SF +L+     +
Sbjct: 553 -------TVRCVFWDLGRNGGRGGWSDNGCSVKDRRLNETICTCSHLTSFGVLLDLSRTS 605

Query: 539 HYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTT-IHLHLCICLFVGSTIF 597
               +   LT IT +G  LS   L + ++T++    I+    + I + LC  L + + +F
Sbjct: 606 VLPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVF 665

Query: 598 LAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLS-TRWLC 656
           L        ++   C  VA  LHY  L +F WM LE   +Y  +V+VF           C
Sbjct: 666 LLDSWIALYKMQGLCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFC 725

Query: 657 LIGYGVPLLIVGVSAAIYSKGYGRPRY-----------CWLDFEQGFLWSFLGPVTFIIL 705
           ++G+GVP ++V +   I    YG   Y           CW++    F  + +G    I L
Sbjct: 726 IVGWGVPAVVVTIILTISPDNYGLGSYGKFPNGSPDDFCWINNNAVFYITVVGYFCVIFL 785

Query: 706 CNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQL-------FLLGCTWVFGLF 758
            N  +F+  + +L +        +KK K+  A   T+I  L       FLLG TW F  F
Sbjct: 786 LNVSMFIVVLVQLCR--------IKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFF 837

Query: 759 IFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWAC 802
            +   ++   Y+F I N LQG F+++ +C+  + VR+++R++ C
Sbjct: 838 AWGPVNVTFMYLFAIFNTLQGFFIFIFYCVAKENVRKQWRRYLC 881


>gi|119943120 G protein-coupled receptor 64 isoform 1 [Homo sapiens]
          Length = 1017

 Score =  154 bits (390), Expect = 2e-37
 Identities = 146/584 (25%), Positives = 248/584 (42%), Gaps = 72/584 (12%)

Query: 254 TVCEDMTFSTWTPPPG----VHSQTLSRFFDKVQDLGRDSKTSSAEVTIQN-VIKLVDEL 308
           TV      +T + PP     V++ ++S   ++V  + +     S E  +   +I  V  L
Sbjct: 349 TVSAPANVNTTSAPPVQTDIVNTSSISDLENQVLQMEKALSLGSLEPNLAGEMINQVSRL 408

Query: 309 MEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTELTLMIQERG 368
           + +P D+  LAP     +A +LL  ++DI   L  S      T IS ++  L L +    
Sbjct: 409 LHSPPDM--LAP-----LAQRLLKVVDDIGLQLNFSN-----TTISLTSPSLALAVIRVN 456

Query: 369 DKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLNLHSKKQAELEE 428
             +       A+   N  V+   + P  ++  I    ++   L    + L S+ Q    E
Sbjct: 457 ASSFNTTTFVAQDPANLQVSLETQAPENSIGTITLPSSLMNNLPAHDMELASRVQFNFFE 516

Query: 429 ----IYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDPPAKD 484
                 + S+  + L  +S V S  +++   + L   +     H+  S  E         
Sbjct: 517 TPALFQDPSLENLSL--ISYVISSSVANLTVRNLTRNVTVTLKHINPSQDEL-------- 566

Query: 485 VMPGPRQELLCAFWKSDSDRG-GHWATEGCQVLGSKNGSTTCQCSHLSSFAILM-----A 538
                   + C FW    + G G W+  GC V   +   T C CSHL+SF +L+     +
Sbjct: 567 -------TVRCVFWDLGRNGGRGGWSDNGCSVKDRRLNETICTCSHLTSFGVLLDLSRTS 619

Query: 539 HYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTT-IHLHLCICLFVGSTIF 597
               +   LT IT +G  LS   L + ++T++    I+    + I + LC  L + + +F
Sbjct: 620 VLPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVF 679

Query: 598 LAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLS-TRWLC 656
           L        ++   C  VA  LHY  L +F WM LE   +Y  +V+VF           C
Sbjct: 680 LLDSWIALYKMQGLCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFC 739

Query: 657 LIGYGVPLLIVGVSAAIYSKGYGRPRY-----------CWLDFEQGFLWSFLGPVTFIIL 705
           ++G+GVP ++V +   I    YG   Y           CW++    F  + +G    I L
Sbjct: 740 IVGWGVPAVVVTIILTISPDNYGLGSYGKFPNGSPDDFCWINNNAVFYITVVGYFCVIFL 799

Query: 706 CNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQL-------FLLGCTWVFGLF 758
            N  +F+  + +L +        +KK K+  A   T+I  L       FLLG TW F  F
Sbjct: 800 LNVSMFIVVLVQLCR--------IKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFF 851

Query: 759 IFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWAC 802
            +   ++   Y+F I N LQG F+++ +C+  + VR+++R++ C
Sbjct: 852 AWGPVNVTFMYLFAIFNTLQGFFIFIFYCVAKENVRKQWRRYLC 895


>gi|119943129 G protein-coupled receptor 64 isoform 4 [Homo sapiens]
          Length = 1014

 Score =  154 bits (390), Expect = 2e-37
 Identities = 146/584 (25%), Positives = 248/584 (42%), Gaps = 72/584 (12%)

Query: 254 TVCEDMTFSTWTPPPG----VHSQTLSRFFDKVQDLGRDSKTSSAEVTIQN-VIKLVDEL 308
           TV      +T + PP     V++ ++S   ++V  + +     S E  +   +I  V  L
Sbjct: 346 TVSAPANVNTTSAPPVQTDIVNTSSISDLENQVLQMEKALSLGSLEPNLAGEMINQVSRL 405

Query: 309 MEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTELTLMIQERG 368
           + +P D+  LAP     +A +LL  ++DI   L  S      T IS ++  L L +    
Sbjct: 406 LHSPPDM--LAP-----LAQRLLKVVDDIGLQLNFSN-----TTISLTSPSLALAVIRVN 453

Query: 369 DKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLNLHSKKQAELEE 428
             +       A+   N  V+   + P  ++  I    ++   L    + L S+ Q    E
Sbjct: 454 ASSFNTTTFVAQDPANLQVSLETQAPENSIGTITLPSSLMNNLPAHDMELASRVQFNFFE 513

Query: 429 ----IYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDPPAKD 484
                 + S+  + L  +S V S  +++   + L   +     H+  S  E         
Sbjct: 514 TPALFQDPSLENLSL--ISYVISSSVANLTVRNLTRNVTVTLKHINPSQDEL-------- 563

Query: 485 VMPGPRQELLCAFWKSDSDRG-GHWATEGCQVLGSKNGSTTCQCSHLSSFAILM-----A 538
                   + C FW    + G G W+  GC V   +   T C CSHL+SF +L+     +
Sbjct: 564 -------TVRCVFWDLGRNGGRGGWSDNGCSVKDRRLNETICTCSHLTSFGVLLDLSRTS 616

Query: 539 HYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTT-IHLHLCICLFVGSTIF 597
               +   LT IT +G  LS   L + ++T++    I+    + I + LC  L + + +F
Sbjct: 617 VLPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVF 676

Query: 598 LAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLS-TRWLC 656
           L        ++   C  VA  LHY  L +F WM LE   +Y  +V+VF           C
Sbjct: 677 LLDSWIALYKMQGLCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFC 736

Query: 657 LIGYGVPLLIVGVSAAIYSKGYGRPRY-----------CWLDFEQGFLWSFLGPVTFIIL 705
           ++G+GVP ++V +   I    YG   Y           CW++    F  + +G    I L
Sbjct: 737 IVGWGVPAVVVTIILTISPDNYGLGSYGKFPNGSPDDFCWINNNAVFYITVVGYFCVIFL 796

Query: 706 CNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQL-------FLLGCTWVFGLF 758
            N  +F+  + +L +        +KK K+  A   T+I  L       FLLG TW F  F
Sbjct: 797 LNVSMFIVVLVQLCR--------IKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFF 848

Query: 759 IFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWAC 802
            +   ++   Y+F I N LQG F+++ +C+  + VR+++R++ C
Sbjct: 849 AWGPVNVTFMYLFAIFNTLQGFFIFIFYCVAKENVRKQWRRYLC 892


>gi|56237021 fibrillin 3 precursor [Homo sapiens]
          Length = 2809

 Score =  153 bits (387), Expect = 6e-37
 Identities = 92/235 (39%), Positives = 112/235 (47%), Gaps = 32/235 (13%)

Query: 13   LTLPGAETQDSRGCAR---WCPQNSSCVN---ATACRCNPGFSSFSEIITTPTETCDDIN 66
            LT  G   +D   C+     CP +  CVN   A  C C+ GF S     T   + C DIN
Sbjct: 1104 LTAKGTACEDIDECSLSDGLCP-HGQCVNVIGAFQCSCHAGFQS-----TPDRQGCVDIN 1157

Query: 67   ECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRL 126
            EC   +    G    C NTEGSY C C  GY  +   +         C DVDEC++NPR+
Sbjct: 1158 ECRVQNG---GCDVHCINTEGSYRCSCGQGYSLMPDGRA--------CADVDECEENPRV 1206

Query: 127  CKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQC 186
            C   G C N  G + C C  GF   P D + C DV+EC    + C     C N  GS+ C
Sbjct: 1207 CDQ-GHCTNMPGGHRCLCYDGFMATP-DMRTCVDVDECDLNPHICLHGD-CENTKGSFVC 1263

Query: 187  RCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGW 241
             C+ G+    G+      T C DVDEC  G H CDS   C N  GS+SCRC PGW
Sbjct: 1264 HCQLGYMVRKGA------TGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGW 1312



 Score =  130 bits (326), Expect = 7e-30
 Identities = 84/240 (35%), Positives = 111/240 (46%), Gaps = 32/240 (13%)

Query: 13   LTLPGAETQDSRGC---ARW------CPQNSSCVNATACRCNPGFSSFSEIITTPTETCD 63
            +TLPG    D   C   A W      CP   S   A+ C    GF+S   +   P     
Sbjct: 928  VTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYK-- 985

Query: 64   DINECAT-PSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQ 122
            D+NEC   P   + G    C NT GS+ C C+ G+          +  E  C D+DEC+ 
Sbjct: 986  DVNECKVFPGLCTHGT---CRNTVGSFHCACAGGFA--------LDAQERNCTDIDECRI 1034

Query: 123  NPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVG 182
            +P LC   GTCVNT GS+ C+C PG++      K C DV+EC      C   T C N  G
Sbjct: 1035 SPDLC-GQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGT-CTNTDG 1092

Query: 183  SYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWK 242
            SY+C+C PG +           T CED+DECS     C     C N +G++ C C  G++
Sbjct: 1093 SYKCQCPPGHELT------AKGTACEDIDECSLSDGLCPHGQ-CVNVIGAFQCSCHAGFQ 1145



 Score =  129 bits (325), Expect = 9e-30
 Identities = 82/262 (31%), Positives = 111/262 (42%), Gaps = 58/262 (22%)

Query: 35   SCVNATA---CRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDC 91
            +CVN      C C PG+ S   ++    + C D++ECA    +  G    C NT+GSY C
Sbjct: 1043 TCVNTPGSFECECFPGYESGFMLM----KNCMDVDECARDPLLCRG--GTCTNTDGSYKC 1096

Query: 92   VCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFI 151
             C PG+E  +            C+D+DEC  +  LC  +G CVN +G++ C C  GF+  
Sbjct: 1097 QCPPGHELTAKG--------TACEDIDECSLSDGLCP-HGQCVNVIGAFQCSCHAGFQST 1147

Query: 152  PEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGS------------- 198
            P D + C D+NEC      C    HC+N  GSY+C C  G+  +P               
Sbjct: 1148 P-DRQGCVDINECRVQNGGC--DVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENP 1204

Query: 199  -----------PNG------------PNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSC 235
                       P G            P+   C DVDEC    H C     C NT GS+ C
Sbjct: 1205 RVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGD-CENTKGSFVC 1263

Query: 236  RCRPGWKPRHGIPNNQKDTVCE 257
             C+ G+  R G         CE
Sbjct: 1264 HCQLGYMVRKGATGCSDVDECE 1285



 Score =  125 bits (313), Expect = 2e-28
 Identities = 77/231 (33%), Positives = 111/231 (48%), Gaps = 34/231 (14%)

Query: 14   TLPGAETQDSRGCARWCPQNSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINECAT 70
            T  G +  + R  A  C  +  C+N+     C C  G++           TC D++EC+ 
Sbjct: 2358 TAEGRDVDECRMLAHLCA-HGECINSLGSFRCHCQAGYTP-----DATATTCLDMDECSQ 2411

Query: 71   PSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSY 130
              K  C     C NT+GS+ C C  GY           E   TC+D+DEC      C+  
Sbjct: 2412 VPK-PCTFL--CKNTKGSFLCSCPRGY--------LLEEDGRTCKDLDECTSRQHNCQFL 2460

Query: 131  GTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRP 190
              CVNT+G++TC+C PGF    +  + C D +EC++   PC +  HC N  GS++C C  
Sbjct: 2461 --CVNTVGAFTCRCPPGFT---QHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQ 2515

Query: 191  GWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGW 241
            G+  +  S +G     CEDV+EC  G H+C     C N +G Y C C  G+
Sbjct: 2516 GF-TLVSSGHG-----CEDVNEC-DGPHRCQHG--CQNQLGGYRCSCPQGF 2557



 Score =  124 bits (310), Expect = 5e-28
 Identities = 82/246 (33%), Positives = 111/246 (45%), Gaps = 35/246 (14%)

Query: 30   CPQNSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINECAT-PSKVSCGKFSDCWNT 85
            C QN+ C+N      C+C  G+        +P   C   NEC   P+  S G   DC +T
Sbjct: 1774 CQQNADCINIPGSYRCKCTRGYK------LSPGGACVGRNECREIPNVCSHG---DCMDT 1824

Query: 86   EGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCL 145
            EGSY C+C  G++         +  +  C D+DEC + P  C + GTC N +GSY C C 
Sbjct: 1825 EGSYMCLCHRGFQA--------SADQTLCMDIDECDRQP--CGN-GTCKNIIGSYNCLCF 1873

Query: 146  PGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNT 205
            PGF         C D +ECT+         HCLN  GS+ C C+ G++      N     
Sbjct: 1874 PGFVVTHNGD--CVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKN----- 1926

Query: 206  VCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPR--HGIPNNQKDTVCEDMTFST 263
             C D +EC S    C   T C N  GS+ C C PG++ +  H I  ++         F T
Sbjct: 1927 -CVDTNECLSLAGTCLPGT-CQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFGT 1984

Query: 264  WTPPPG 269
             T  PG
Sbjct: 1985 CTNSPG 1990



 Score =  120 bits (300), Expect = 7e-27
 Identities = 72/213 (33%), Positives = 106/213 (49%), Gaps = 30/213 (14%)

Query: 33   NSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSY 89
            N  C+N      C C  GF+  S ++      C+D++EC +     C + +DC N  GSY
Sbjct: 1734 NGICINQIGSFRCECPAGFNYNSILLA-----CEDVDECGSRES-PCQQNADCINIPGSY 1787

Query: 90   DCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFK 149
             C C+ GY+   G           C   +EC++ P +C S+G C++T GSY C C  GF+
Sbjct: 1788 RCKCTRGYKLSPGG---------ACVGRNECREIPNVC-SHGDCMDTEGSYMCLCHRGFQ 1837

Query: 150  FIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCED 209
                D  +C D++EC   + PC + T C N +GSY C C PG+          +N  C D
Sbjct: 1838 -ASADQTLCMDIDECD--RQPCGNGT-CKNIIGSYNCLCFPGFVVT-------HNGDCVD 1886

Query: 210  VDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWK 242
             DEC++   Q      C NT GS+ C C+ G++
Sbjct: 1887 FDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFE 1919



 Score =  113 bits (283), Expect = 6e-25
 Identities = 73/211 (34%), Positives = 101/211 (47%), Gaps = 33/211 (15%)

Query: 30   CPQNSSCVN---ATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTE 86
            C  ++SC+N   + +CRC PG+             C D++EC +     C    DC N  
Sbjct: 1291 CDSHASCLNIPGSFSCRCLPGWVGDGF-------ECHDLDECVSQEH-RCSPRGDCLNVP 1342

Query: 87   GSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLP 146
            GSY C C  G+   +G   F       C+D DEC +N  LC + G C+N  G Y C+C  
Sbjct: 1343 GSYRCTCRQGF---AGDGFF-------CEDRDECAENVDLCDN-GQCLNAPGGYRCECEM 1391

Query: 147  GFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTV 206
            GF    ED + C DV+EC  G N C   + C N  G ++C C  G++   G  N      
Sbjct: 1392 GFD-PTEDHRACQDVDECAQG-NLCAFGS-CENLPGMFRCICNGGYELDRGGGN------ 1442

Query: 207  CEDVDECSSGQHQCDSSTVCFNTVGSYSCRC 237
            C D++EC+   +  +   VC NT GSY C C
Sbjct: 1443 CTDINECADPVNCING--VCINTPGSYLCSC 1471



 Score =  110 bits (276), Expect = 4e-24
 Identities = 69/218 (31%), Positives = 96/218 (44%), Gaps = 29/218 (13%)

Query: 30   CPQNSSCVNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSY 89
            CPQ  S      C    G       +  P ++ +D+NECA    V       C NT+GS+
Sbjct: 2056 CPQEGSAAFQELCPFGHG------AVPGPDDSREDVNECAENPGVCTNGV--CVNTDGSF 2107

Query: 90   DCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFK 149
             C C  GY          + +   C D DEC          GTC N +G + C C  GF+
Sbjct: 2108 RCECPFGYS--------LDFTGINCVDTDECSVGHPC--GQGTCTNVIGGFECACADGFE 2157

Query: 150  FIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCED 209
              P     C D++EC+   NP   +  C N  GSY C C  G+          +  +C D
Sbjct: 2158 --PGLMMTCEDIDECSL--NPLLCAFRCHNTEGSYLCTCPAGYTL------REDGAMCRD 2207

Query: 210  VDECSSGQHQCDSSTV-CFNTVGSYSCRCRPGWKPRHG 246
            VDEC+ GQ  C +  + C N +G+++C C PG +P  G
Sbjct: 2208 VDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPG 2245



 Score =  110 bits (274), Expect = 7e-24
 Identities = 70/199 (35%), Positives = 92/199 (46%), Gaps = 30/199 (15%)

Query: 42  CRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVS 101
           C CN G++            C D++EC +    S     DC N  G+Y C C PG++   
Sbjct: 433 CECNVGYTQ------DVRGECIDVDECTS----SPCHHGDCVNIPGTYHCRCYPGFQATP 482

Query: 102 GAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDV 161
                   +   C DVDEC  +  LC   G CVNT GS+ C C  GF+  P D K C D 
Sbjct: 483 --------TRQACVDVDECIVSGGLCH-LGRCVNTEGSFQCVCNAGFELSP-DGKNCVDH 532

Query: 162 NECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCD 221
           NEC +    C +   CLN  GS+ C C+PG+   PG         C D+DEC +     +
Sbjct: 533 NECATS-TMCVNGV-CLNEDGSFSCLCKPGFLLAPG------GHYCMDIDECQTPGICVN 584

Query: 222 SSTVCFNTVGSYSCRCRPG 240
               C NT GS+ C+C  G
Sbjct: 585 GH--CTNTEGSFRCQCLGG 601



 Score =  107 bits (267), Expect = 5e-23
 Identities = 82/289 (28%), Positives = 110/289 (38%), Gaps = 79/289 (27%)

Query: 22   DSRGCA---------RWCPQNSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINECA 69
            D R CA         R C Q   C N      C C  GF +     T    TC D++EC 
Sbjct: 1190 DGRACADVDECEENPRVCDQGH-CTNMPGGHRCLCYDGFMA-----TPDMRTCVDVDECD 1243

Query: 70   TPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKS 129
                +      DC NT+GS+ C C  GY    GA          C DVDEC+     C S
Sbjct: 1244 LNPHICL--HGDCENTKGSFVCHCQLGYMVRKGA--------TGCSDVDECEVGGHNCDS 1293

Query: 130  YGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCH----------------- 172
            + +C+N  GS++C+CLPG+     D   C D++EC S ++ C                  
Sbjct: 1294 HASCLNIPGSFSCRCLPGWV---GDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCR 1350

Query: 173  -----------------------SSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCED 209
                                    +  CLN  G Y+C C  G+ P        ++  C+D
Sbjct: 1351 QGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPT------EDHRACQD 1404

Query: 210  VDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCED 258
            VDEC+ G      S  C N  G + C C  G++   G  N      C D
Sbjct: 1405 VDECAQGNLCAFGS--CENLPGMFRCICNGGYELDRGGGNCTDINECAD 1451



 Score =  107 bits (266), Expect = 6e-23
 Identities = 77/204 (37%), Positives = 92/204 (45%), Gaps = 41/204 (20%)

Query: 16  PGAETQDSRGCA----------RWCPQNSSCVNATACRCNPGFSSFSEIITTPTETCDDI 65
           PG  T+    CA          + CP   S      C    G       ITT      DI
Sbjct: 634 PGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLG-------ITTDGR---DI 683

Query: 66  NECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPR 125
           NECA   +V       C N  GSY CVC+ GYE  +  K         C DVDEC  N  
Sbjct: 684 NECALDPEVCANGV--CENLRGSYRCVCNLGYEAGASGKD--------CTDVDECALNSL 733

Query: 126 LCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQ 185
           LC + G C N+ GSY+C C PGF F  +D ++C DV+EC S  +PC S   C N  GSY 
Sbjct: 734 LCDN-GWCQNSPGSYSCSCPPGFHFW-QDTEICKDVDECLS--SPCVSGV-CRNLAGSYT 788

Query: 186 CRCRPGWQPIPGSPNGPNNTVCED 209
           C+C       PGS   P+ T C D
Sbjct: 789 CKCG------PGSRLDPSGTFCLD 806



 Score =  107 bits (266), Expect = 6e-23
 Identities = 73/212 (34%), Positives = 97/212 (45%), Gaps = 38/212 (17%)

Query: 36   CVN---ATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDCV 92
            CVN   A  CRC PGF       T   + C D +EC+      CG    C NT GS+ C 
Sbjct: 2461 CVNTVGAFTCRCPPGF-------TQHHQACFDNDECSAQPG-PCGAHGHCHNTPGSFRCE 2512

Query: 93   CSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIP 152
            C  G+  VS        S + C+DV+EC   P  C+    C N LG Y C C  GF    
Sbjct: 2513 CHQGFTLVS--------SGHGCEDVNECD-GPHRCQH--GCQNQLGGYRCSCPQGFTQHS 2561

Query: 153  EDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGW---QPIPGSPNGPNNTVCED 209
            +  + C D NEC      C S++ C N +G ++C C  G+   Q + G         C++
Sbjct: 2562 QWAQ-CVDENECALSPPTCGSAS-CRNTLGGFRCVCPSGFDFDQALGG---------CQE 2610

Query: 210  VDECSSGQHQCDSSTVCFNTVGSYSCRCRPGW 241
            VDEC+  +  C  S  C NT G + C C  G+
Sbjct: 2611 VDECAGRRGPCSYS--CANTPGGFLCGCPQGY 2640



 Score =  106 bits (264), Expect = 1e-22
 Identities = 74/235 (31%), Positives = 107/235 (45%), Gaps = 41/235 (17%)

Query: 33   NSSCVNATA---CRCNPGFSSFSEIITTPTET-CDDINE---CATPSKVSCGKFSDCWNT 85
            N  CVN      C C+ GF        +PT T C DI +    A   +  C   S     
Sbjct: 2265 NGRCVNTAGSFRCDCDEGFQP------SPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEA 2318

Query: 86   EGSYDCVCSPGYE--------PVSGAKTFK----NESENTCQ--DVDECQQNPRLCKSYG 131
                +C C  G          P+ G   ++    + S  T +  DVDEC+    LC ++G
Sbjct: 2319 VTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLC-AHG 2377

Query: 132  TCVNTLGSYTCQCLPGFKFIPE-DPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRP 190
             C+N+LGS+ C C  G+   P+     C D++EC+    PC  +  C N  GS+ C C  
Sbjct: 2378 ECINSLGSFRCHCQAGYT--PDATATTCLDMDECSQVPKPC--TFLCKNTKGSFLCSCPR 2433

Query: 191  GWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRH 245
            G+          +   C+D+DEC+S QH C    +C NTVG+++CRC PG+   H
Sbjct: 2434 GYLL------EEDGRTCKDLDECTSRQHNCQF--LCVNTVGAFTCRCPPGFTQHH 2480



 Score =  105 bits (263), Expect = 1e-22
 Identities = 62/182 (34%), Positives = 82/182 (45%), Gaps = 22/182 (12%)

Query: 64   DINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQN 123
            DI+EC     +       C N  GS+ C C  G+          N     C+DVDEC   
Sbjct: 1721 DIDECGEIPAICANGI--CINQIGSFRCECPAGFN--------YNSILLACEDVDECGSR 1770

Query: 124  PRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGS 183
               C+    C+N  GSY C+C  G+K  P     C   NEC    N C S   C++  GS
Sbjct: 1771 ESPCQQNADCINIPGSYRCKCTRGYKLSPGG--ACVGRNECREIPNVC-SHGDCMDTEGS 1827

Query: 184  YQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKP 243
            Y C C  G+Q         + T+C D+DEC   +  C + T C N +GSY+C C PG+  
Sbjct: 1828 YMCLCHRGFQA------SADQTLCMDIDECD--RQPCGNGT-CKNIIGSYNCLCFPGFVV 1878

Query: 244  RH 245
             H
Sbjct: 1879 TH 1880



 Score =  105 bits (263), Expect = 1e-22
 Identities = 76/243 (31%), Positives = 105/243 (43%), Gaps = 35/243 (14%)

Query: 13   LTLPGAETQDSRGCARWCP-QNSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINEC 68
            L   G    D+  C+   P    +C N      C C  GF     +      TC+DI+EC
Sbjct: 2117 LDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMM------TCEDIDEC 2170

Query: 69   ATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCK 128
            +    +   +   C NTEGSY C C  GY           E    C+DVDEC    + C 
Sbjct: 2171 SLNPLLCAFR---CHNTEGSYLCTCPAGYT--------LREDGAMCRDVDECADGQQDCH 2219

Query: 129  SYGT-CVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCR 187
            + G  C N +G++ C C PG + +P   + CTD NEC +  + C +   C+N  GS++C 
Sbjct: 2220 ARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNG-RCVNTAGSFRCD 2278

Query: 188  CRPGWQPIPGSPNGPNNTVCEDVDE--CSSG--QHQCDSSTVCFNTVGSYSCRC--RPGW 241
            C  G+QP       P  T C D+ +  C +   Q  C S +     V    C C    GW
Sbjct: 2279 CDEGFQP------SPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGW 2332

Query: 242  KPR 244
             PR
Sbjct: 2333 GPR 2335



 Score =  105 bits (261), Expect = 2e-22
 Identities = 62/160 (38%), Positives = 83/160 (51%), Gaps = 22/160 (13%)

Query: 82  CWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYT 141
           C  T  SY C C+ GY           +    C DVDEC  +P  C  +G CVN  G+Y 
Sbjct: 424 CLPTPSSYRCECNVGYT---------QDVRGECIDVDECTSSP--CH-HGDCVNIPGTYH 471

Query: 142 CQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNG 201
           C+C PGF+  P   + C DV+EC      CH    C+N  GS+QC C  G++    SP+G
Sbjct: 472 CRCYPGFQATP-TRQACVDVDECIVSGGLCHLG-RCVNTEGSFQCVCNAGFEL---SPDG 526

Query: 202 PNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGW 241
            N   C D +EC++    C +  VC N  GS+SC C+PG+
Sbjct: 527 KN---CVDHNECATST-MCVNG-VCLNEDGSFSCLCKPGF 561



 Score =  101 bits (252), Expect = 3e-21
 Identities = 86/293 (29%), Positives = 112/293 (38%), Gaps = 97/293 (33%)

Query: 22  DSRGCA--RWCPQNSSCVNAT--------ACRCNPGFSSFSEIITTPTETCDDINECATP 71
           D + C     C  ++ CVN          +C C PGF     ++      C DI+EC TP
Sbjct: 525 DGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGF-----LLAPGGHYCMDIDECQTP 579

Query: 72  SKVSCGKFSDCWNTEGSYDC----------------------VCSPGYEPVSGAKTFKN- 108
                G    C NTEGS+ C                       C    E  S A+ F   
Sbjct: 580 GICVNGH---CTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGT 636

Query: 109 --ESENTC------------------------------------QDVDECQQNPRLCKSY 130
             +SE  C                                    +D++EC  +P +C + 
Sbjct: 637 VTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCAN- 695

Query: 131 GTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRP 190
           G C N  GSY C C  G++      K CTDV+EC      C +   C N+ GSY C C P
Sbjct: 696 GVCENLRGSYRCVCNLGYE-AGASGKDCTDVDECALNSLLCDNGW-CQNSPGSYSCSCPP 753

Query: 191 G---WQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPG 240
           G   WQ         +  +C+DVDEC S    C S  VC N  GSY+C+C PG
Sbjct: 754 GFHFWQ---------DTEICKDVDECLSSP--CVSG-VCRNLAGSYTCKCGPG 794



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 60/170 (35%), Positives = 78/170 (45%), Gaps = 23/170 (13%)

Query: 26   CARWCPQNSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDC 82
            C R    N +C N      C C PGF      + T    C D +EC T     C +F  C
Sbjct: 1851 CDRQPCGNGTCKNIIGSYNCLCFPGF------VVTHNGDCVDFDECTTLVGQVC-RFGHC 1903

Query: 83   WNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTC 142
             NT GS+ C+C  G+E  +  K         C D +EC      C   GTC N  GS+ C
Sbjct: 1904 LNTAGSFHCLCQDGFELTADGK--------NCVDTNECLSLAGTCLP-GTCQNLEGSFRC 1954

Query: 143  QCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGW 192
             C PGF+   +    C D++EC+   N C   T C N+ GS+QC C PG+
Sbjct: 1955 ICPPGFQVQSDH---CIDIDECSEEPNLCLFGT-CTNSPGSFQCLCPPGF 2000



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 73/240 (30%), Positives = 105/240 (43%), Gaps = 47/240 (19%)

Query: 32   QNSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGS 88
            Q   CVN      C C PG+      ++  T  C+DI+EC+T S + CG    C+NT G+
Sbjct: 1575 QGGDCVNTFGSFQCECPPGYH-----LSEHTRICEDIDECSTHSGI-CGP-GTCYNTLGN 1627

Query: 89   YDCVCSPGYEPVSGAK----------------TFKNE-SENTCQDVDECQQN-----PRL 126
            Y CVC   Y  V+G                  T +NE + N  + +  C  N      R 
Sbjct: 1628 YTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRP 1687

Query: 127  CKSYGTCVNTLGSYTC-QCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQ 185
            C++  T ++      C    PGF       K   D++EC      C +   C+N +GS++
Sbjct: 1688 CEACPTPISPDYQILCGNQAPGFLTDIHTGKP-LDIDECGEIPAICANGI-CINQIGSFR 1745

Query: 186  CRCRPGWQPIPGSPNGPNNTV---CEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWK 242
            C C  G+           N++   CEDVDEC S +  C  +  C N  GSY C+C  G+K
Sbjct: 1746 CECPAGFN---------YNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYK 1796



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 68/230 (29%), Positives = 95/230 (41%), Gaps = 43/230 (18%)

Query: 36  CVNATA---CRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDCV 92
           CVN      C CN GF      ++   + C D NECAT +    G    C N +GS+ C+
Sbjct: 505 CVNTEGSFQCVCNAGFE-----LSPDGKNCVDHNECATSTMCVNGV---CLNEDGSFSCL 556

Query: 93  CSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIP 152
           C PG+    G         + C D+DECQ  P +C + G C NT GS+ CQCL G   + 
Sbjct: 557 CKPGFLLAPGG--------HYCMDIDECQ-TPGICVN-GHCTNTEGSFRCQCLGGLA-VG 605

Query: 153 EDPKVCTDVN---ECTSGQNPCHSSTHCLNNVGSYQCRCR-------PGWQPIPGSPNGP 202
            D +VC D +    C         +      V   +C C           Q  P   +  
Sbjct: 606 TDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAE 665

Query: 203 NNTVCE----------DVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWK 242
              +C           D++EC+     C ++ VC N  GSY C C  G++
Sbjct: 666 FQALCSSGLGITTDGRDINECALDPEVC-ANGVCENLRGSYRCVCNLGYE 714



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 74/266 (27%), Positives = 100/266 (37%), Gaps = 73/266 (27%)

Query: 33   NSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSY 89
            N  C+NA     C C  GF       T     C D++ECA  +  +   F  C N  G +
Sbjct: 1375 NGQCLNAPGGYRCECEMGFDP-----TEDHRACQDVDECAQGNLCA---FGSCENLPGMF 1426

Query: 90   DCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFK 149
             C+C+ GYE   G           C D++EC  +P  C + G C+NT GSY C C   F+
Sbjct: 1427 RCICNGGYELDRGG--------GNCTDINECA-DPVNCIN-GVCINTPGSYLCSCPQDFE 1476

Query: 150  FIPEDPKVCTDVNE-------------------------------CTSGQ---NPCHSST 175
              P     C D                                  C+ G+   NPC    
Sbjct: 1477 LNPSGVG-CVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCP 1535

Query: 176  HCLNNVGSYQCRCRPGWQPIPGSPNGPN--NTVCEDVDECSSGQHQCDSSTVCFNTVGSY 233
              + N   Y+  C PG     G    PN    + ED+DEC      C     C NT GS+
Sbjct: 1536 --MANTTEYRTLC-PG-----GEGFQPNRITVILEDIDECQELPGLCQGGD-CVNTFGSF 1586

Query: 234  SCRCRPGWKPRHGIPNNQKDTVCEDM 259
             C C PG+        ++   +CED+
Sbjct: 1587 QCECPPGYH------LSEHTRICEDI 1606



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 50/129 (38%), Positives = 66/129 (51%), Gaps = 15/129 (11%)

Query: 115 QDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPK-VCTDVNECTSGQNPCHS 173
           Q +D C+    LC + G C+ T  SY C+C  G+    +D +  C DV+ECTS  +PCH 
Sbjct: 407 QTIDICRHFTNLCLN-GRCLPTPSSYRCECNVGYT---QDVRGECIDVDECTS--SPCHH 460

Query: 174 STHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSY 233
              C+N  G+Y CRC PG+Q  P          C DVDEC      C     C NT GS+
Sbjct: 461 GD-CVNIPGTYHCRCYPGFQATP------TRQACVDVDECIVSGGLCHLGR-CVNTEGSF 512

Query: 234 SCRCRPGWK 242
            C C  G++
Sbjct: 513 QCVCNAGFE 521



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 51/166 (30%), Positives = 72/166 (43%), Gaps = 24/166 (14%)

Query: 30   CPQNSSCVNATA---CRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTE 86
            C  +  C N      C C+ GF+     + +    C+D+NEC  P +   G    C N  
Sbjct: 2496 CGAHGHCHNTPGSFRCECHQGFT-----LVSSGHGCEDVNECDGPHRCQHG----CQNQL 2546

Query: 87   GSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLP 146
            G Y C C  G+         ++     C D +EC  +P  C S  +C NTLG + C C  
Sbjct: 2547 GGYRCSCPQGFT--------QHSQWAQCVDENECALSPPTCGS-ASCRNTLGGFRCVCPS 2597

Query: 147  GFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGW 192
            GF F  +    C +V+EC   + PC  S  C N  G + C C  G+
Sbjct: 2598 GFDF-DQALGGCQEVDECAGRRGPC--SYSCANTPGGFLCGCPQGY 2640



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 40/121 (33%), Positives = 62/121 (51%), Gaps = 7/121 (5%)

Query: 115  QDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSS 174
            +D+DECQ+ P LC+  G CVNT GS+ C+C PG+  + E  ++C D++EC++    C   
Sbjct: 1562 EDIDECQELPGLCQG-GDCVNTFGSFQCECPPGY-HLSEHTRICEDIDECSTHSGICGPG 1619

Query: 175  THCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYS 234
            T C N +G+Y C C   +  +    NG NN +      C    +    + + FN      
Sbjct: 1620 T-CYNTLGNYTCVCPAEYLQV----NGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMC 1674

Query: 235  C 235
            C
Sbjct: 1675 C 1675



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 66/234 (28%), Positives = 87/234 (37%), Gaps = 41/234 (17%)

Query: 44   CNPGFSSFSEIITTPTETCDDINECAT-PSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSG 102
            C  GF+  + +      TCDD+NEC + P     G+   C NT GS+ C C  G    + 
Sbjct: 855  CARGFARMTGV------TCDDVNECESFPGVCPNGR---CVNTAGSFRCECPEGLMLDAS 905

Query: 103  AKTFKNESENTC---QDVDECQQNPRLCKSYGTCVNTLGSY---TCQCLP---------- 146
             +   +     C    D DEC            C  ++G+     C+  P          
Sbjct: 906  GRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASL 965

Query: 147  ---GFKFIPED----PKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSP 199
               G  F   D         DVNEC      C   T C N VGS+ C C  G+       
Sbjct: 966  CPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGT-CRNTVGSFHCACAGGFALDAQER 1024

Query: 200  NGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKD 253
            N      C D+DEC      C   T C NT GS+ C C PG++    +  N  D
Sbjct: 1025 N------CTDIDECRISPDLCGQGT-CVNTPGSFECECFPGYESGFMLMKNCMD 1071



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 74/291 (25%), Positives = 110/291 (37%), Gaps = 90/291 (30%)

Query: 29   WCPQNSSCVNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVS------------- 75
            WC QNS    + +C C PGF  + +     TE C D++EC +   VS             
Sbjct: 739  WC-QNSP--GSYSCSCPPGFHFWQD-----TEICKDVDECLSSPCVSGVCRNLAGSYTCK 790

Query: 76   CGKFS---------------DCW----------NTEGSY---DCVCSPG----------- 96
            CG  S                CW          N +G+    +C  + G           
Sbjct: 791  CGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCE 850

Query: 97   YEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPK 156
             +P   A+ F   +  TC DV+EC+  P +C + G CVNT GS+ C+C  G   +    +
Sbjct: 851  IDPAC-ARGFARMTGVTCDDVNECESFPGVCPN-GRCVNTAGSFRCECPEGL-MLDASGR 907

Query: 157  VCTDV-----------NECTSGQNPCHSSTHCLNNVGS---YQCRCRPGWQPIPGS---P 199
            +C DV           +EC       +    C  ++G+    +C   P  + +  +   P
Sbjct: 908  LCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCP 967

Query: 200  NG---------PNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGW 241
             G               +DV+EC      C   T C NTVGS+ C C  G+
Sbjct: 968  RGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGT-CRNTVGSFHCACAGGF 1017



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 39/145 (26%), Positives = 51/145 (35%), Gaps = 16/145 (11%)

Query: 26  CARWCPQNSSCVNATACRCNPGFSSFS---EIITTPT------ETCD-DINECATPSKVS 75
           C R C     C+    C C  GF       +  T P       E C   +        + 
Sbjct: 151 CDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALC 210

Query: 76  CGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVN 135
           C      W       C   P            N     CQDVDECQ  P LC+  G+CVN
Sbjct: 211 CATVGRAWGLP----CELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQG-GSCVN 265

Query: 136 TLGSYTCQCLPGFKFIPEDPKVCTD 160
            +GS+ C+C  G + + +    C D
Sbjct: 266 MVGSFHCRCPVGHR-LSDSSAACED 289



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 72/273 (26%), Positives = 90/273 (32%), Gaps = 61/273 (22%)

Query: 3   GRVFLAFCV--WLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTE 60
           G  F A+C   W T PG        C R C +   C     C C  G         T   
Sbjct: 61  GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGF-CSQPNLCTCADG---------TLAP 110

Query: 61  TCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYE-PVSGAKTFKNESEN--TCQDV 117
           +C       +   VSC     C        C+C  GY   V G         N   C   
Sbjct: 111 SCGVSR--GSGCSVSCMNGGTCRGAS----CLCQKGYTGTVCGQPICDRGCHNGGRCIGP 164

Query: 118 DECQ-----QNPRLCKSY--GTCVNTLGSYTCQC-LPGFKFIPEDPKVCTDVNEC-TSGQ 168
           + C        P+  + Y  G C   +G   CQ  L G         VCT    C T G+
Sbjct: 165 NRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGL--------VCTKALCCATVGR 216

Query: 169 N---PCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTV 225
               PC           +    CR G+  IP    G     C+DVDEC +    C   + 
Sbjct: 217 AWGLPCELCP-------AQPHPCRRGF--IPNIHTG----ACQDVDECQAVPGLCQGGS- 262

Query: 226 CFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCED 258
           C N VGS+ CRC  G +       +     CED
Sbjct: 263 CVNMVGSFHCRCPVGHR------LSDSSAACED 289


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.441 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,725,865
Number of Sequences: 37866
Number of extensions: 1767206
Number of successful extensions: 9501
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 189
Number of HSP's successfully gapped in prelim test: 118
Number of HSP's that attempted gapping in prelim test: 4531
Number of HSP's gapped (non-prelim): 1417
length of query: 835
length of database: 18,247,518
effective HSP length: 111
effective length of query: 724
effective length of database: 14,044,392
effective search space: 10168139808
effective search space used: 10168139808
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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