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Search of human proteins with 169790811
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169790811 SHC (Src homology 2 domain containing)
transforming protein 2 [Homo sapiens]
(582 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169790811 SHC (Src homology 2 domain containing) transforming... 1203 0.0
gi|194239662 SHC (Src homology 2 domain containing) transforming... 505 e-143
gi|194239664 SHC (Src homology 2 domain containing) transforming... 504 e-143
gi|194239668 SHC (Src homology 2 domain containing) transforming... 484 e-136
gi|32261324 SHC (Src homology 2 domain containing) transforming ... 483 e-136
gi|224586793 src homology 2 domain-containing transforming prote... 461 e-129
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ... 431 e-121
gi|222446609 rai-like protein [Homo sapiens] 374 e-103
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 72 2e-12
gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens] 62 2e-09
gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Hom... 60 6e-09
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 60 7e-09
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 60 7e-09
gi|242247193 SH2B adaptor protein 2 [Homo sapiens] 59 2e-08
gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 57 5e-08
gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens] 57 5e-08
gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 57 5e-08
gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens] 57 5e-08
gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 57 5e-08
gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens] 55 1e-07
gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens] 55 1e-07
gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens] 55 1e-07
gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens] 55 1e-07
gi|208609985 SH2 domain containing 3A [Homo sapiens] 54 3e-07
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 51 3e-06
gi|4885455 SH2B adaptor protein 3 [Homo sapiens] 51 3e-06
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 50 4e-06
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 50 4e-06
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 50 4e-06
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 50 4e-06
>gi|169790811 SHC (Src homology 2 domain containing) transforming
protein 2 [Homo sapiens]
Length = 582
Score = 1203 bits (3112), Expect = 0.0
Identities = 582/582 (100%), Positives = 582/582 (100%)
Query: 1 MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGA 60
MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGA
Sbjct: 1 MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGA 60
Query: 61 DPQPEPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGSRGGRGAAGSGDAA 120
DPQPEPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGSRGGRGAAGSGDAA
Sbjct: 61 DPQPEPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGSRGGRGAAGSGDAA 120
Query: 121 AAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTR 180
AAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTR
Sbjct: 121 AAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTR 180
Query: 181 EAINRLHEAVPGVRGSWKKKAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQ 240
EAINRLHEAVPGVRGSWKKKAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQ
Sbjct: 181 EAINRLHEAVPGVRGSWKKKAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQ 240
Query: 241 VIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFEL 300
VIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFEL
Sbjct: 241 VIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFEL 300
Query: 301 RFKQYLHSPPKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALT 360
RFKQYLHSPPKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALT
Sbjct: 301 RFKQYLHSPPKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALT 360
Query: 361 QPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGL 420
QPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGL
Sbjct: 361 QPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGL 420
Query: 421 DAPEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEE 480
DAPEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEE
Sbjct: 421 DAPEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEE 480
Query: 481 QLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGV 540
QLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGV
Sbjct: 481 QLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGV 540
Query: 541 VRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSREP 582
VRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSREP
Sbjct: 541 VRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSREP 582
>gi|194239662 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 1 [Homo sapiens]
Length = 583
Score = 505 bits (1300), Expect = e-143
Identities = 290/616 (47%), Positives = 369/616 (59%), Gaps = 89/616 (14%)
Query: 1 MTQGPGGRAPP-----------APPAPPEP--EAPTTFCALLPRMPQWKFAAPGGFLGRG 47
+ +G G PP P PP P ++PTT C+ PRM + A P
Sbjct: 21 LEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCSFFPRMSNLRLANP------- 73
Query: 48 PAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGS 107
AG G+ +P A G ++GA P PLP L +
Sbjct: 74 ------AGGRPGSKGEPGRAADDG-----EGIVGAAMPDSG---PLPLL---QDMNKLSG 116
Query: 108 RGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSM 167
GGR G EW R GSF++KP GWLHP+ +V+GPGVSY+VRYMGC+EVL+SM
Sbjct: 117 GGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSM 176
Query: 168 RSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAP-NKALASVLGKSNLRFAGMSISIHI 226
R+LDFNTRTQVTREAI+ + EAVPG +G+ +++ P ++ L+S+LG+SNL+FAGM I++ +
Sbjct: 177 RALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTV 236
Query: 227 STDGLSLSVPATRQVIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGL 286
ST L+L +Q+IANHHM SISFASGGD D +YVAYVAKDP+NQRACHILEC EGL
Sbjct: 237 STSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGL 296
Query: 287 AQSIISTVGQAFELRFKQYLHSPPKVALPPERLAGPEESAWGDEEDS-LEHNYYNSIPGK 345
AQ +IST+GQAFELRFKQYL +PPK+ P +R+AG + SAW +EE+ +H YYN PGK
Sbjct: 297 AQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGK 356
Query: 346 EPPLGGLVDSRL--ALTQPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADA 403
EPPLGG+VD RL A +PS A +LP G GD V+
Sbjct: 357 EPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGA-TLP-----VGQPVGGDPEVRKQM 410
Query: 404 RGPPD------HEEHLYVNTQGLDA------------PEPEDSPKKDLFDMRPFEDALKL 445
PP ++ YVN Q LD P S +DLFDM+PFEDAL++
Sbjct: 411 PPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRV 470
Query: 446 HECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADG 505
PP + +A EQLR EPW+HG++SRR AE +L+ +G
Sbjct: 471 ---------------------PPPPQSVSMA---EQLRGEPWFHGKLSRREAEALLQLNG 506
Query: 506 DFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQNGQPI 565
DFLVR+S T PGQYVLTG+ +GQPKHLLLVDPEGVVRTKD FES+SHLI +H+ N PI
Sbjct: 507 DFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPI 566
Query: 566 VAAESELHLRGVVSRE 581
++A SEL L+ V R+
Sbjct: 567 ISAGSELCLQQPVERK 582
>gi|194239664 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 3 [Homo sapiens]
Length = 584
Score = 504 bits (1299), Expect = e-143
Identities = 290/617 (47%), Positives = 369/617 (59%), Gaps = 90/617 (14%)
Query: 1 MTQGPGGRAPP-----------APPAPPEP--EAPTTFCALLPRMPQWKFAAPGGFLGRG 47
+ +G G PP P PP P ++PTT C+ PRM + A P
Sbjct: 21 LEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCSFFPRMSNLRLANP------- 73
Query: 48 PAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGS 107
AG G+ +P A G ++GA P PLP L +
Sbjct: 74 ------AGGRPGSKGEPGRAADDG-----EGIVGAAMPDSG---PLPLL---QDMNKLSG 116
Query: 108 RGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSM 167
GGR G EW R GSF++KP GWLHP+ +V+GPGVSY+VRYMGC+EVL+SM
Sbjct: 117 GGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSM 176
Query: 168 RSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAP-NKALASVLGKSNLRFAGMSISIHI 226
R+LDFNTRTQVTREAI+ + EAVPG +G+ +++ P ++ L+S+LG+SNL+FAGM I++ +
Sbjct: 177 RALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTV 236
Query: 227 STDGLSLSVPATRQVIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGL 286
ST L+L +Q+IANHHM SISFASGGD D +YVAYVAKDP+NQRACHILEC EGL
Sbjct: 237 STSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGL 296
Query: 287 AQSIISTVGQAFELRFKQYLHSPPKVALPPERLAGPEESAWGDEEDS-LEHNYYNSIPGK 345
AQ +IST+GQAFELRFKQYL +PPK+ P +R+AG + SAW +EE+ +H YYN PGK
Sbjct: 297 AQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGK 356
Query: 346 EPPLGGLVDSRL--ALTQPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADA 403
EPPLGG+VD RL A +PS A +LP G GD V+
Sbjct: 357 EPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGA-TLP-----VGQPVGGDPEVRKQM 410
Query: 404 RGPPD-------HEEHLYVNTQGLDA------------PEPEDSPKKDLFDMRPFEDALK 444
PP ++ YVN Q LD P S +DLFDM+PFEDAL+
Sbjct: 411 PPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALR 470
Query: 445 LHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRAD 504
+ PP + +A EQLR EPW+HG++SRR AE +L+ +
Sbjct: 471 V---------------------PPPPQSVSMA---EQLRGEPWFHGKLSRREAEALLQLN 506
Query: 505 GDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQNGQP 564
GDFLVR+S T PGQYVLTG+ +GQPKHLLLVDPEGVVRTKD FES+SHLI +H+ N P
Sbjct: 507 GDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLP 566
Query: 565 IVAAESELHLRGVVSRE 581
I++A SEL L+ V R+
Sbjct: 567 IISAGSELCLQQPVERK 583
>gi|194239668 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 4 [Homo sapiens]
Length = 473
Score = 484 bits (1245), Expect = e-136
Identities = 260/495 (52%), Positives = 328/495 (66%), Gaps = 52/495 (10%)
Query: 109 GGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMR 168
GGR G EW R GSF++KP GWLHP+ +V+GPGVSY+VRYMGC+EVL+SMR
Sbjct: 8 GGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMR 67
Query: 169 SLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAP-NKALASVLGKSNLRFAGMSISIHIS 227
+LDFNTRTQVTREAI+ + EAVPG +G+ +++ P ++ L+S+LG+SNL+FAGM I++ +S
Sbjct: 68 ALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVS 127
Query: 228 TDGLSLSVPATRQVIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLA 287
T L+L +Q+IANHHM SISFASGGD D +YVAYVAKDP+NQRACHILEC EGLA
Sbjct: 128 TSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLA 187
Query: 288 QSIISTVGQAFELRFKQYLHSPPKVALPPERLAGPEESAWGDEEDS-LEHNYYNSIPGKE 346
Q +IST+GQAFELRFKQYL +PPK+ P +R+AG + SAW +EE+ +H YYN PGKE
Sbjct: 188 QDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKE 247
Query: 347 PPLGGLVDSRL--ALTQPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADAR 404
PPLGG+VD RL A +PS A +LP G GD V+
Sbjct: 248 PPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGA-TLP-----VGQPVGGDPEVRKQMP 301
Query: 405 GPPD------HEEHLYVNTQGLDA------------PEPEDSPKKDLFDMRPFEDALKLH 446
PP ++ YVN Q LD P S +DLFDM+PFEDAL++
Sbjct: 302 PPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRV- 360
Query: 447 ECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGD 506
PP + +A EQLR EPW+HG++SRR AE +L+ +GD
Sbjct: 361 --------------------PPPPQSVSMA---EQLRGEPWFHGKLSRREAEALLQLNGD 397
Query: 507 FLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIV 566
FLVR+S T PGQYVLTG+ +GQPKHLLLVDPEGVVRTKD FES+SHLI +H+ N PI+
Sbjct: 398 FLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPII 457
Query: 567 AAESELHLRGVVSRE 581
+A SEL L+ V R+
Sbjct: 458 SAGSELCLQQPVERK 472
>gi|32261324 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 2 [Homo sapiens]
Length = 474
Score = 483 bits (1244), Expect = e-136
Identities = 260/496 (52%), Positives = 328/496 (66%), Gaps = 53/496 (10%)
Query: 109 GGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMR 168
GGR G EW R GSF++KP GWLHP+ +V+GPGVSY+VRYMGC+EVL+SMR
Sbjct: 8 GGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMR 67
Query: 169 SLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAP-NKALASVLGKSNLRFAGMSISIHIS 227
+LDFNTRTQVTREAI+ + EAVPG +G+ +++ P ++ L+S+LG+SNL+FAGM I++ +S
Sbjct: 68 ALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVS 127
Query: 228 TDGLSLSVPATRQVIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLA 287
T L+L +Q+IANHHM SISFASGGD D +YVAYVAKDP+NQRACHILEC EGLA
Sbjct: 128 TSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLA 187
Query: 288 QSIISTVGQAFELRFKQYLHSPPKVALPPERLAGPEESAWGDEEDS-LEHNYYNSIPGKE 346
Q +IST+GQAFELRFKQYL +PPK+ P +R+AG + SAW +EE+ +H YYN PGKE
Sbjct: 188 QDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKE 247
Query: 347 PPLGGLVDSRL--ALTQPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADAR 404
PPLGG+VD RL A +PS A +LP G GD V+
Sbjct: 248 PPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGA-TLP-----VGQPVGGDPEVRKQMP 301
Query: 405 GPPD-------HEEHLYVNTQGLDA------------PEPEDSPKKDLFDMRPFEDALKL 445
PP ++ YVN Q LD P S +DLFDM+PFEDAL++
Sbjct: 302 PPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRV 361
Query: 446 HECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADG 505
PP + +A EQLR EPW+HG++SRR AE +L+ +G
Sbjct: 362 ---------------------PPPPQSVSMA---EQLRGEPWFHGKLSRREAEALLQLNG 397
Query: 506 DFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQNGQPI 565
DFLVR+S T PGQYVLTG+ +GQPKHLLLVDPEGVVRTKD FES+SHLI +H+ N PI
Sbjct: 398 DFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPI 457
Query: 566 VAAESELHLRGVVSRE 581
++A SEL L+ V R+
Sbjct: 458 ISAGSELCLQQPVERK 473
>gi|224586793 src homology 2 domain-containing transforming protein
C3 [Homo sapiens]
Length = 594
Score = 461 bits (1185), Expect = e-129
Identities = 264/530 (49%), Positives = 330/530 (62%), Gaps = 35/530 (6%)
Query: 71 GVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGSRGGRGAAGSGDAAAAAEWIRKG- 129
G+ L++A R + C P+L+ G+A S A A RKG
Sbjct: 80 GLRGLSSAARERAGARLSGSCSAPSLA-----------APDGSAPSAPRAPAMSAARKGR 128
Query: 130 ---SFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTREAINRL 186
+ +P G H +VLGPGV+YVV+Y+GCIEVLRSMRSLDF+TRTQ+TREAI+R+
Sbjct: 129 PGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAISRV 188
Query: 187 HEAVPGVRGSWKK-KAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQVIANH 245
EAVPG +G++KK K P+K L+S+LGKSNL+FAGMSIS+ IST L+L P ++Q+IANH
Sbjct: 189 CEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANH 248
Query: 246 HMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFELRFKQY 305
HM SISFASGGD D TDYVAYVAKDP+N+RACHILECC+GLAQ +I ++GQAFELRFKQY
Sbjct: 249 HMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQY 308
Query: 306 LHSPPKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALTQPCAL 365
L P K+ +R+ +E +E D +H YYNSIP K PP GG +D+RL
Sbjct: 309 LQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPD 368
Query: 366 TALDQGPSPSLRDACSLPWDVGSTGTAPP---GDGYVQADARG----PPDHEEHLYVNTQ 418
TA G + L G P G + + G P E YVNTQ
Sbjct: 369 TAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQ 428
Query: 419 GLD-------APEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTR 471
+ E SP+KDLFDM+PFEDALK A+ + SP +
Sbjct: 429 QIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASV-----ECISPVSP 483
Query: 472 RAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKH 531
RAP A E+L+ E WY G MSR+ AE +L DGDFLVR S TNPG +VLTGMH GQ KH
Sbjct: 484 RAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKH 543
Query: 532 LLLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSRE 581
LLLVDPEG +RTKD +F+SISHLI+HHL++ PIV+A SEL L+ V R+
Sbjct: 544 LLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERK 593
>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
sapiens]
Length = 475
Score = 431 bits (1109), Expect = e-121
Identities = 206/206 (100%), Positives = 206/206 (100%)
Query: 377 RDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGLDAPEPEDSPKKDLFDM 436
RDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGLDAPEPEDSPKKDLFDM
Sbjct: 270 RDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGLDAPEPEDSPKKDLFDM 329
Query: 437 RPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRA 496
RPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRA
Sbjct: 330 RPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRA 389
Query: 497 AERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLID 556
AERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLID
Sbjct: 390 AERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLID 449
Query: 557 HHLQNGQPIVAAESELHLRGVVSREP 582
HHLQNGQPIVAAESELHLRGVVSREP
Sbjct: 450 HHLQNGQPIVAAESELHLRGVVSREP 475
Score = 58.2 bits (139), Expect = 2e-08
Identities = 33/59 (55%), Positives = 36/59 (61%), Gaps = 8/59 (13%)
Query: 132 IHKPAHGWLHPDAR------VLGPGVSYVVR--YMGCIEVLRSMRSLDFNTRTQVTREA 182
IH P H +HP V P + YMGCIEVLRSMRSLDFNTRTQVTR+A
Sbjct: 214 IHPPIHPSIHPSTHPPTHPPVPHPSTHPSIHPSYMGCIEVLRSMRSLDFNTRTQVTRDA 272
>gi|222446609 rai-like protein [Homo sapiens]
Length = 630
Score = 374 bits (961), Expect = e-103
Identities = 243/619 (39%), Positives = 319/619 (51%), Gaps = 92/619 (14%)
Query: 6 GGRAPPAPPAP-------------PEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAA-- 50
G + P PP P P E+PT C L+PRM K A P L
Sbjct: 51 GNKGSPQPPHPALAPHLPTEDATLPSQESPTPLCTLIPRMASMKLANPATLLSLKNFCLG 110
Query: 51 -----------ARAAGASGGADPQPEPAGPGGVPALAAAVLG-ACEPRCAAPCPLPALSR 98
+R G+SG + P+ + G P ++G CPLP
Sbjct: 111 TKEVPRLKLQESRDPGSSGPSSPETSLSRSGTAPPPQQDLVGHRATALTPDSCPLP---- 166
Query: 99 CRGAGSRGSRGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYM 158
G G+ + R H +LG G++Y VRYM
Sbjct: 167 ----------------GPGEPTLRSRQDR-------------HFLQHLLGMGMNYCVRYM 197
Query: 159 GCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKK-KAPNKALASVLGKSNLRF 217
GC+EVL+SMRSLDF RTQVTREAI+RL EAVPG G+ KK K P K L++VLGKSNL+F
Sbjct: 198 GCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRKPPVKFLSTVLGKSNLQF 257
Query: 218 AGMSISIHISTDGLSLSVPATRQVIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRAC 277
+GM+I + IST L+L +Q+IANHHM SISFASGGD D TDYVAYVAKDP+NQRAC
Sbjct: 258 SGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNQRAC 317
Query: 278 HILECCEGLAQSIISTVGQAFELRFKQYLHSPPKVALPPERLAGPEESAWGDEEDSLEHN 337
HILEC G+AQ +IST+GQAFELRFKQYL +P E E+ +H
Sbjct: 318 HILECHNGMAQDVISTIGQAFELRFKQYLKNPSL----NTSCESEEVHIDSHAEEREDHE 373
Query: 338 YYNSIPGKEPPLGGLVDSRLAL--TQPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPG 395
YYN IPGK+PP+GG+ D R+ + T+ A + C LP G +
Sbjct: 374 YYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPI------QCEKLCYLP------GNSKCS 421
Query: 396 DGYVQADARGPPDHEEHLYVNTQGLDAPEPEDSPKKDLFDMRPFEDALKLHECSVAAGVT 455
Y + H D + + + DLFD + + L +AG
Sbjct: 422 SVYENCLEQSRAIGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGNQ 481
Query: 456 AAPLPLEDQW-------------PSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLR 502
+ PL W + P + ++QL E YHG++SR+AAE +L
Sbjct: 482 RSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLLV 541
Query: 503 ADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQNG 562
DGDFLVR+S T+PGQYVL+G+ GQ KHLLLVDPEG VRTKD +F+++ HLI +H+ N
Sbjct: 542 KDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNS 601
Query: 563 QPIVAAESELHLRGVVSRE 581
PI+++ SE+ L+ V ++
Sbjct: 602 LPIISSGSEVSLKQPVRKD 620
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 71.6 bits (174), Expect = 2e-12
Identities = 34/91 (37%), Positives = 54/91 (59%)
Query: 475 VAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLL 534
++ +E+ L ++ WYHG + R A+ +L+ GDFLVR+S PG+YVL+ GQ +H ++
Sbjct: 448 ISISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFII 507
Query: 535 VDPEGVVRTKDVLFESISHLIDHHLQNGQPI 565
+ + R + F +I LIDHH Q I
Sbjct: 508 QYVDNMYRFEGTGFSNIPQLIDHHYTTKQVI 538
>gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens]
Length = 825
Score = 61.6 bits (148), Expect = 2e-09
Identities = 34/99 (34%), Positives = 54/99 (54%), Gaps = 13/99 (13%)
Query: 478 TEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDP 537
+ E LR WYHGR+ R+ +E +++ DGDFLVRDS+++PG +VLT +H +
Sbjct: 145 SSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKI--N 202
Query: 538 EGVVRTKDVL-----------FESISHLIDHHLQNGQPI 565
V+R + F+SI L+ ++ N +PI
Sbjct: 203 RTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPI 241
>gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Homo
sapiens]
Length = 304
Score = 60.1 bits (144), Expect = 6e-09
Identities = 70/313 (22%), Positives = 125/313 (39%), Gaps = 58/313 (18%)
Query: 130 SFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTREAINRLHEA 189
+F K W+H + + Y +++G EV + T+V R+A+ +L A
Sbjct: 4 AFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKG-------TEVVRDAVRKLKFA 56
Query: 190 VPGVRGSWKKKAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQVIANHHMPS 249
++ S +K P + + IS G+ + P T++V N +
Sbjct: 57 -RHIKKSEGQKIPK------------------VELQISIYGVKILEPKTKEVQHNCQLHR 97
Query: 250 ISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFELRFKQYLHSP 309
ISF + TD + N+ C++ + E A+ I T+GQAF+L ++++L S
Sbjct: 98 ISFCADDKTDKRIFTFICKDSESNKHLCYVFDS-EKCAEEITLTIGQAFDLAYRKFLESG 156
Query: 310 PKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALTQPCALTALD 369
K +++AG ++ E +++E + K L +++L +TQ A A
Sbjct: 157 GKDVETRKQIAGLQKRIQDLETENME------LKNKVQDL----ENQLRITQVSAPPAGS 206
Query: 370 QGP-SPSLRDACSLPWD-VGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGLDAPEPED 427
P SPS +P+ + + P +G TQ P
Sbjct: 207 MTPKSPSTDIFDMIPFSPISHQSSMPTRNG-------------------TQPPPVPSRST 247
Query: 428 SPKKDLFDMRPFE 440
K+DLF PF+
Sbjct: 248 EIKRDLFGAEPFD 260
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 59.7 bits (143), Expect = 7e-09
Identities = 34/98 (34%), Positives = 52/98 (53%), Gaps = 3/98 (3%)
Query: 468 PPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAG 527
PP + P ++ L ++ WYHG + R +L GDFLVR+S +YVL+ + G
Sbjct: 385 PPLQLIP--EVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRES-QGKQEYVLSVLWDG 441
Query: 528 QPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQNGQPI 565
P+H ++ + + R + F SI LIDH L QP+
Sbjct: 442 LPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPL 479
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 59.7 bits (143), Expect = 7e-09
Identities = 34/98 (34%), Positives = 52/98 (53%), Gaps = 3/98 (3%)
Query: 468 PPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAG 527
PP + P ++ L ++ WYHG + R +L GDFLVR+S +YVL+ + G
Sbjct: 443 PPLQLIP--EVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRES-QGKQEYVLSVLWDG 499
Query: 528 QPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQNGQPI 565
P+H ++ + + R + F SI LIDH L QP+
Sbjct: 500 LPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPL 537
>gi|242247193 SH2B adaptor protein 2 [Homo sapiens]
Length = 675
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/112 (33%), Positives = 60/112 (53%), Gaps = 7/112 (6%)
Query: 474 PVAPTEEQLRQEPWYHGRMSRRAAERMLRADGD-----FLVRDSVTNPGQYVLTGMHAGQ 528
P A E +L PW+HG +SR A +++ A G F++R S T PG+YVLT G+
Sbjct: 447 PEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGK 506
Query: 529 PKHL-LLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAES-ELHLRGVV 578
KHL L ++ G + + F+S+ ++ H + P+ + S ++ LR V
Sbjct: 507 AKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYV 558
>gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 57.0 bits (136), Expect = 5e-08
Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 6/98 (6%)
Query: 479 EEQLRQEPWYHGRMSRRAAERMLRADGD-----FLVRDSVTNPGQYVLTGMHAGQPKHL- 532
++ L PW+HG +SR A +++ G FLVR S T G+YVLT G+ KHL
Sbjct: 519 DQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLR 578
Query: 533 LLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAES 570
L ++ EG R + + F+SI +++H + P+ + S
Sbjct: 579 LSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
>gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens]
Length = 683
Score = 57.0 bits (136), Expect = 5e-08
Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 6/98 (6%)
Query: 479 EEQLRQEPWYHGRMSRRAAERMLRADGD-----FLVRDSVTNPGQYVLTGMHAGQPKHL- 532
++ L PW+HG +SR A +++ G FLVR S T G+YVLT G+ KHL
Sbjct: 519 DQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLR 578
Query: 533 LLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAES 570
L ++ EG R + + F+SI +++H + P+ + S
Sbjct: 579 LSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
>gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 57.0 bits (136), Expect = 5e-08
Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 6/98 (6%)
Query: 479 EEQLRQEPWYHGRMSRRAAERMLRADGD-----FLVRDSVTNPGQYVLTGMHAGQPKHL- 532
++ L PW+HG +SR A +++ G FLVR S T G+YVLT G+ KHL
Sbjct: 519 DQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLR 578
Query: 533 LLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAES 570
L ++ EG R + + F+SI +++H + P+ + S
Sbjct: 579 LSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
>gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens]
Length = 756
Score = 57.0 bits (136), Expect = 5e-08
Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 6/98 (6%)
Query: 479 EEQLRQEPWYHGRMSRRAAERMLRADGD-----FLVRDSVTNPGQYVLTGMHAGQPKHL- 532
++ L PW+HG +SR A +++ G FLVR S T G+YVLT G+ KHL
Sbjct: 519 DQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLR 578
Query: 533 LLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAES 570
L ++ EG R + + F+SI +++H + P+ + S
Sbjct: 579 LSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
Score = 35.8 bits (81), Expect = 0.11
Identities = 32/97 (32%), Positives = 40/97 (41%), Gaps = 12/97 (12%)
Query: 13 PPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGADPQPEPAGPGGV 72
PP PPEP + T P P + A+ R P A AA A+ + E AG GGV
Sbjct: 640 PPQPPEPPSWTD-----PPQPGAEEAS------RAPEVAAAAAAAAKERQEKEKAGGGGV 688
Query: 73 PALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGSRG 109
P V+ P + S +GAGS G G
Sbjct: 689 PEELVPVV-ELVPVVELEEAIAPGSEAQGAGSGGDAG 724
>gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 57.0 bits (136), Expect = 5e-08
Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 6/98 (6%)
Query: 479 EEQLRQEPWYHGRMSRRAAERMLRADGD-----FLVRDSVTNPGQYVLTGMHAGQPKHL- 532
++ L PW+HG +SR A +++ G FLVR S T G+YVLT G+ KHL
Sbjct: 519 DQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLR 578
Query: 533 LLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAES 570
L ++ EG R + + F+SI +++H + P+ + S
Sbjct: 579 LSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
>gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens]
Length = 700
Score = 55.5 bits (132), Expect = 1e-07
Identities = 24/50 (48%), Positives = 33/50 (66%)
Query: 482 LRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKH 531
LR WYHGR+ R +E +++ +GDFL+RDS+T+ G YVLT Q H
Sbjct: 55 LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALH 104
>gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens]
Length = 702
Score = 55.5 bits (132), Expect = 1e-07
Identities = 24/50 (48%), Positives = 33/50 (66%)
Query: 482 LRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKH 531
LR WYHGR+ R +E +++ +GDFL+RDS+T+ G YVLT Q H
Sbjct: 57 LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALH 106
>gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens]
Length = 703
Score = 55.5 bits (132), Expect = 1e-07
Identities = 24/50 (48%), Positives = 33/50 (66%)
Query: 482 LRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKH 531
LR WYHGR+ R +E +++ +GDFL+RDS+T+ G YVLT Q H
Sbjct: 58 LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALH 107
>gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]
Length = 860
Score = 55.5 bits (132), Expect = 1e-07
Identities = 24/50 (48%), Positives = 33/50 (66%)
Query: 482 LRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKH 531
LR WYHGR+ R +E +++ +GDFL+RDS+T+ G YVLT Q H
Sbjct: 215 LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALH 264
>gi|208609985 SH2 domain containing 3A [Homo sapiens]
Length = 576
Score = 54.3 bits (129), Expect = 3e-07
Identities = 34/112 (30%), Positives = 54/112 (48%), Gaps = 9/112 (8%)
Query: 480 EQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLV---- 535
E L +PWYHG +SR+ AE +L+ +GDFLVR S + G V++ G H +
Sbjct: 8 EDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVAL 67
Query: 536 -----DPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSREP 582
P + + +D F SI L+ ++ +P+ A + R V + P
Sbjct: 68 RPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGP 119
Score = 30.0 bits (66), Expect = 6.1
Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 6/39 (15%)
Query: 8 RAPPAPPAPPE------PEAPTTFCALLPRMPQWKFAAP 40
+AP PP P E P T+C L+PR+P + +P
Sbjct: 208 KAPTKPPRTPSFELPDASERPPTYCELVPRVPSVQGTSP 246
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 51.2 bits (121), Expect = 3e-06
Identities = 31/101 (30%), Positives = 52/101 (51%), Gaps = 7/101 (6%)
Query: 481 QLRQEPWYHGRMSRRAAERML---RADGDFLVRDSVTNPGQYVLTGMHAGQPKHL-LLVD 536
+++ PW+ G++ R AE ML R DG FL+R+S + PG + L+ +H +L D
Sbjct: 54 EMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRD 113
Query: 537 PEGVVRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGV 577
G V F S++ L+D+H V+ ++ LR +
Sbjct: 114 GAGKYFLWVVKFNSLNELVDYHRSTS---VSRNQQIFLRDI 151
>gi|4885455 SH2B adaptor protein 3 [Homo sapiens]
Length = 575
Score = 51.2 bits (121), Expect = 3e-06
Identities = 33/94 (35%), Positives = 50/94 (53%), Gaps = 6/94 (6%)
Query: 478 TEEQLRQEPWYHGRMSRRAAERMLR-----ADGDFLVRDSVTNPGQYVLTGMHAGQPKHL 532
T+ L PW+HG +SR A ++++ A G FLVR S T G+YVLT G KHL
Sbjct: 355 TDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHL 414
Query: 533 -LLVDPEGVVRTKDVLFESISHLIDHHLQNGQPI 565
L + G R + + F S+ ++ H ++ P+
Sbjct: 415 RLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPL 448
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 50.4 bits (119), Expect = 4e-06
Identities = 29/81 (35%), Positives = 48/81 (59%), Gaps = 4/81 (4%)
Query: 482 LRQEPWYHGRMSRRAAERMLRA--DGDFLVRDSVTNPGQYVLTGMHAGQPKHLLL-VDPE 538
L + WYHG +SR AAE +L + +G FLVR+S ++PGQ ++ + G+ H + +
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 212
Query: 539 G-VVRTKDVLFESISHLIDHH 558
G V T + F +++ L+ HH
Sbjct: 213 GKVYVTAESRFSTLAELVHHH 233
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 50.4 bits (119), Expect = 4e-06
Identities = 29/81 (35%), Positives = 48/81 (59%), Gaps = 4/81 (4%)
Query: 482 LRQEPWYHGRMSRRAAERMLRA--DGDFLVRDSVTNPGQYVLTGMHAGQPKHLLL-VDPE 538
L + WYHG +SR AAE +L + +G FLVR+S ++PGQ ++ + G+ H + +
Sbjct: 168 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 227
Query: 539 G-VVRTKDVLFESISHLIDHH 558
G V T + F +++ L+ HH
Sbjct: 228 GKVYVTAESRFSTLAELVHHH 248
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 50.4 bits (119), Expect = 4e-06
Identities = 29/81 (35%), Positives = 48/81 (59%), Gaps = 4/81 (4%)
Query: 482 LRQEPWYHGRMSRRAAERMLRA--DGDFLVRDSVTNPGQYVLTGMHAGQPKHLLL-VDPE 538
L + WYHG +SR AAE +L + +G FLVR+S ++PGQ ++ + G+ H + +
Sbjct: 147 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 206
Query: 539 G-VVRTKDVLFESISHLIDHH 558
G V T + F +++ L+ HH
Sbjct: 207 GKVYVTAESRFSTLAELVHHH 227
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 50.4 bits (119), Expect = 4e-06
Identities = 29/81 (35%), Positives = 48/81 (59%), Gaps = 4/81 (4%)
Query: 482 LRQEPWYHGRMSRRAAERMLRA--DGDFLVRDSVTNPGQYVLTGMHAGQPKHLLL-VDPE 538
L + WYHG +SR AAE +L + +G FLVR+S ++PGQ ++ + G+ H + +
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 212
Query: 539 G-VVRTKDVLFESISHLIDHH 558
G V T + F +++ L+ HH
Sbjct: 213 GKVYVTAESRFSTLAELVHHH 233
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,151,363
Number of Sequences: 37866
Number of extensions: 1760623
Number of successful extensions: 18200
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 132
Number of HSP's successfully gapped in prelim test: 852
Number of HSP's that attempted gapping in prelim test: 13220
Number of HSP's gapped (non-prelim): 4479
length of query: 582
length of database: 18,247,518
effective HSP length: 108
effective length of query: 474
effective length of database: 14,157,990
effective search space: 6710887260
effective search space used: 6710887260
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.