Search of human proteins with 16933533

Search of human proteins with 16933533

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide
43 isoform 2 [Homo sapiens]
         (503 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...  1016   0.0  
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...  1011   0.0  
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ...   845   0.0  
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   792   0.0  
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   780   0.0  
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   750   0.0  
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H...   304   1e-82
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H...   304   1e-82
gi|195972900 thromboxane A synthase 1, platelet isoform TXS-II [...   240   2e-63
gi|30023836 cytochrome P450 4Z1 [Homo sapiens]                        177   3e-44
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ...   167   2e-41
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide...   166   6e-41
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   162   7e-40
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...   156   5e-38
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...   155   8e-38
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...   155   8e-38
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide...   155   1e-37
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...   155   1e-37
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...   145   6e-35
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide...   144   1e-34
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide...   143   4e-34
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ...   142   5e-34
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide...   142   7e-34
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   129   5e-30
gi|5729796 cytochrome P450, family 46 [Homo sapiens]                  128   1e-29
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   128   1e-29
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   127   2e-29
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   124   2e-28
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   122   6e-28
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid...   121   1e-27

>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score = 1016 bits (2627), Expect = 0.0
 Identities = 503/503 (100%), Positives = 503/503 (100%)

Query: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60
           MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF
Sbjct: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60

Query: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120
           DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF
Sbjct: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120

Query: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180
           AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT
Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180

Query: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240
           MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL
Sbjct: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240

Query: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300
           FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI
Sbjct: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300

Query: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
           IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360

Query: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS 420
           NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS 420

Query: 421 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 480
           KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL
Sbjct: 421 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 480

Query: 481 PILQPEKPIVLKVHLRDGITSGP 503
           PILQPEKPIVLKVHLRDGITSGP
Sbjct: 481 PILQPEKPIVLKVHLRDGITSGP 503


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score = 1011 bits (2615), Expect = 0.0
 Identities = 503/504 (99%), Positives = 503/504 (99%), Gaps = 1/504 (0%)

Query: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60
           MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF
Sbjct: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60

Query: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120
           DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF
Sbjct: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120

Query: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180
           AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT
Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180

Query: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240
           MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL
Sbjct: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240

Query: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300
           FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI
Sbjct: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300

Query: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
           IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360

Query: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE-RF 419
           NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE RF
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRF 420

Query: 420 SKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDN 479
           SKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDN
Sbjct: 421 SKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDN 480

Query: 480 LPILQPEKPIVLKVHLRDGITSGP 503
           LPILQPEKPIVLKVHLRDGITSGP
Sbjct: 481 LPILQPEKPIVLKVHLRDGITSGP 504


>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 3 [Homo sapiens]
          Length = 420

 Score =  845 bits (2182), Expect = 0.0
 Identities = 418/418 (100%), Positives = 418/418 (100%)

Query: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60
           MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF
Sbjct: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60

Query: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120
           DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF
Sbjct: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120

Query: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180
           AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT
Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180

Query: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240
           MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL
Sbjct: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240

Query: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300
           FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI
Sbjct: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300

Query: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
           IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360

Query: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
           NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  792 bits (2045), Expect = 0.0
 Identities = 381/502 (75%), Positives = 436/502 (86%)

Query: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60
           M LIP+ AMETW+L+A SLVLLY+YGTHSH LFKKLGIPGPTPLPFLG IL Y +G   F
Sbjct: 1   MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 60

Query: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120
           D EC++KYG++WG Y+GQQP+L I DPDMIKTVLVKECYSVFTN+ P GP+GF+KSA+S 
Sbjct: 61  DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 120

Query: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180
           AEDEEWKR+R+LLSP FTS K KEMVPII+Q GD+LVR+LR+EAE  K + LKD FGAY+
Sbjct: 121 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 180

Query: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240
           MDVIT T FGVN+DSLNNPQDPF++N KKLL+ DFLDPF L I++FPFL P+ E LNI +
Sbjct: 181 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 240

Query: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300
           FP++VT+FL+ S++RMKESRL+D QKHRVDF Q MIDSQNSKET+SHKALSDLELVAQSI
Sbjct: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300

Query: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
           I IFA Y+TTS+ L FIMYELATHPDVQQKLQEEIDAVLPNKAP TYD ++QMEYLDMVV
Sbjct: 301 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 360

Query: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS 420
           NETLRLFP+  R+ RVCKKD+EING+FIPKG+ VM+P YALH DPKYWTEPEKF PERFS
Sbjct: 361 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS 420

Query: 421 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 480
           KKNKD+ID Y Y PFG+GPRNCIGMRFAL N+KLA+IR LQNFSFKPCKETQIPLKL   
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480

Query: 481 PILQPEKPIVLKVHLRDGITSG 502
            +LQPEKP+VLKV  RDG  SG
Sbjct: 481 GLLQPEKPVVLKVESRDGTVSG 502


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  780 bits (2015), Expect = 0.0
 Identities = 380/502 (75%), Positives = 427/502 (85%), Gaps = 1/502 (0%)

Query: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60
           MDLIPN A+ETW+L+A SLVLLY+YGT +H LFK+LGIPGPTPLP LG +L Y +GLW F
Sbjct: 1   MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF 60

Query: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120
           D EC +KYG+MWG YEGQ P+L I DPD+I+TVLVKECYSVFTN+  LGP+GF+KSA+S 
Sbjct: 61  DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL 120

Query: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180
           AEDEEWKRIR+LLSP FTS K KEM PII+Q GD+LVR+LR+EAE  K + LKD FGAY+
Sbjct: 121 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS 180

Query: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240
           MDVITGT FGVN+DSLNNPQDPF+++ KK LK  FLDP  L I LFPFLTPVFEALN+ L
Sbjct: 181 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL 240

Query: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300
           FPKD  +FL  S+ RMK+SRL DKQKHR+DF Q MIDSQNSKET+SHKALSDLEL AQSI
Sbjct: 241 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI 300

Query: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
           I IFA Y+TTS+ L F +YELATHPDVQQKLQ+EIDAVLPNKAP TYDA+VQMEYLDMVV
Sbjct: 301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 360

Query: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS 420
           NETLRLFPV  R+ R CKKD+EINGVFIPKG  V++P YALHHDPKYWTEPE+F PERFS
Sbjct: 361 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS 420

Query: 421 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 480
           KK KDSID Y Y PFG GPRNCIGMRFAL N+KLA+IR LQNFSFKPCKETQIPLKLD  
Sbjct: 421 KK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ 479

Query: 481 PILQPEKPIVLKVHLRDGITSG 502
            +LQPEKPIVLKV  RDG  SG
Sbjct: 480 GLLQPEKPIVLKVDSRDGTLSG 501


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  750 bits (1937), Expect = 0.0
 Identities = 359/502 (71%), Positives = 424/502 (84%)

Query: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60
           MDLIPN A+ETW+L+A SL+LLY+YGT +H LFKKLGIPGPTPLPFLG  L + +G W F
Sbjct: 1   MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF 60

Query: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120
           D EC +KY ++WG+Y+ QQPML I DPDMIKTVLVKECYSVFTN+ P GP+GF+K+A+S 
Sbjct: 61  DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI 120

Query: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180
           AEDEEWKRIR+LLSP FTS K KEMVPII+Q GD+LVR+LR+EAE  K + LK  FGAY+
Sbjct: 121 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS 180

Query: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240
           MDVIT T FGV++DSLNNPQDPF++N KKLL+ + LDPF+L I +FPFLTP+ EALNI +
Sbjct: 181 MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV 240

Query: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300
           FP+ V  FL  S++++KE RLK+ QKHRVDF Q MIDSQNSK++++HKALSDLEL+AQSI
Sbjct: 241 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI 300

Query: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
           I IFA Y+TTS+ L FI+YELATHPDVQQK+Q+EID VLPNKAP TYD ++Q+EYLDMVV
Sbjct: 301 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV 360

Query: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS 420
           NETLRLFPV  R+ RVCKKD+EING+FIPKG+ VM+P Y LHHDPKYWTEPEKF PERFS
Sbjct: 361 NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS 420

Query: 421 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 480
           KKNKD+ID Y Y PFG+GPRNCIGMRFAL N+KLA++R LQNFSFKPCKETQIPLKL   
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG 480

Query: 481 PILQPEKPIVLKVHLRDGITSG 502
            +L  EKPIVLK   RD   SG
Sbjct: 481 GLLLTEKPIVLKAESRDETVSG 502


>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  304 bits (779), Expect = 1e-82
 Identities = 176/522 (33%), Positives = 277/522 (53%), Gaps = 37/522 (7%)

Query: 6   NFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECN 65
           N  M T  L    L LL  Y T +    +KLG+  P P PF+G + F+ +G W    E  
Sbjct: 13  NGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELR 72

Query: 66  EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLG-PMGFLKSALSFAEDE 124
           + YG + G Y G++  +VI +PDMIK VLV E +S FTN+M  G     +  ++ F  D+
Sbjct: 73  KLYGPLCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDK 131

Query: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
            W+ +R  L  AF+  K  EMVP+ISQ  D+L+  L++ AE+  + +++  +  YT DV+
Sbjct: 132 RWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVV 191

Query: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD 244
               FG  +DS   P+DPF+K+ K+  +     P L+L+  FP +      +       +
Sbjct: 192 ASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDE 251

Query: 245 VTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKE------------------ 283
           +  F    I  +    L+D+Q   + R DF Q ++D+++S                    
Sbjct: 252 LNGFFNKLIRNV--IALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTG 309

Query: 284 -----TKSH------KALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332
                ++ H      + L+  E+V Q+ I + A Y+  + TL F  Y LAT+PD Q+KL 
Sbjct: 310 CKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLL 369

Query: 333 EEIDAVLPNKAPVTYDALVQ-MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKG 391
            E+D          + +L + + YLDMV+ ETLR++P   R TR   +D E+ G  IP G
Sbjct: 370 REVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAG 429

Query: 392 LAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTN 451
             + + + ALHHDP++W  PE F PERF+ + +     + Y+PFGAGPR+C+G+R  L  
Sbjct: 430 AVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLE 489

Query: 452 IKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKV 493
           +KL ++  L  F F+ C ETQ+PL+L++   L P+  + +K+
Sbjct: 490 VKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKI 531


>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  304 bits (779), Expect = 1e-82
 Identities = 176/522 (33%), Positives = 277/522 (53%), Gaps = 37/522 (7%)

Query: 6   NFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECN 65
           N  M T  L    L LL  Y T +    +KLG+  P P PF+G + F+ +G W    E  
Sbjct: 13  NGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELR 72

Query: 66  EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLG-PMGFLKSALSFAEDE 124
           + YG + G Y G++  +VI +PDMIK VLV E +S FTN+M  G     +  ++ F  D+
Sbjct: 73  KLYGPLCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDK 131

Query: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
            W+ +R  L  AF+  K  EMVP+ISQ  D+L+  L++ AE+  + +++  +  YT DV+
Sbjct: 132 RWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVV 191

Query: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD 244
               FG  +DS   P+DPF+K+ K+  +     P L+L+  FP +      +       +
Sbjct: 192 ASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDE 251

Query: 245 VTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKE------------------ 283
           +  F    I  +    L+D+Q   + R DF Q ++D+++S                    
Sbjct: 252 LNGFFNKLIRNV--IALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTG 309

Query: 284 -----TKSH------KALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332
                ++ H      + L+  E+V Q+ I + A Y+  + TL F  Y LAT+PD Q+KL 
Sbjct: 310 CKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLL 369

Query: 333 EEIDAVLPNKAPVTYDALVQ-MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKG 391
            E+D          + +L + + YLDMV+ ETLR++P   R TR   +D E+ G  IP G
Sbjct: 370 REVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAG 429

Query: 392 LAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTN 451
             + + + ALHHDP++W  PE F PERF+ + +     + Y+PFGAGPR+C+G+R  L  
Sbjct: 430 AVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLE 489

Query: 452 IKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKV 493
           +KL ++  L  F F+ C ETQ+PL+L++   L P+  + +K+
Sbjct: 490 VKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKI 531


>gi|195972900 thromboxane A synthase 1, platelet isoform TXS-II
           [Homo sapiens]
          Length = 460

 Score =  240 bits (613), Expect = 2e-63
 Identities = 148/448 (33%), Positives = 230/448 (51%), Gaps = 37/448 (8%)

Query: 6   NFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECN 65
           N  M T  L    L LL  Y T +    +KLG+  P P PF+G + F+ +G W    E  
Sbjct: 13  NGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELR 72

Query: 66  EKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLG-PMGFLKSALSFAEDE 124
           + YG + G Y G++  +VI +PDMIK VLV E +S FTN+M  G     +  ++ F  D+
Sbjct: 73  KLYGPLCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDK 131

Query: 125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
            W+ +R  L  AF+  K  EMVP+ISQ  D+L+  L++ AE+  + +++  +  YT DV+
Sbjct: 132 RWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVV 191

Query: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD 244
               FG  +DS   P+DPF+K+ K+  +     P L+L+  FP +      +       +
Sbjct: 192 ASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDE 251

Query: 245 VTHFLKNSIERMKESRLKDKQ---KHRVDFFQQMIDSQNSKE------------------ 283
           +  F    I  +    L+D+Q   + R DF Q ++D+++S                    
Sbjct: 252 LNGFFNKLIRNV--IALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTG 309

Query: 284 -----TKSH------KALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332
                ++ H      + L+  E+V Q+ I + A Y+  + TL F  Y LAT+PD Q+KL 
Sbjct: 310 CKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLL 369

Query: 333 EEIDAVLPNKAPVTYDALVQ-MEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKG 391
            E+D          + +L + + YLDMV+ ETLR++P   R TR   +D E+ G  IP G
Sbjct: 370 REVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAG 429

Query: 392 LAVMVPIYALHHDPKYWTEPEKFCPERF 419
             + + + ALHHDP++W  PE F PER+
Sbjct: 430 AVLEMAVGALHHDPEHWPSPETFNPERY 457


>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
          Length = 505

 Score =  177 bits (448), Expect = 3e-44
 Identities = 144/500 (28%), Positives = 240/500 (48%), Gaps = 45/500 (9%)

Query: 13  VLVATSLVLLYIYGTHSHK--LFKKLGI-PGPTPLPFLGTILFYLRGLWNFDRECNEKYG 69
           +L+  SL+L  +   +  +  + + L + P P    F G   FY    +    +  EKY 
Sbjct: 18  ILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKLMEKYP 77

Query: 70  EMWGLYEGQQPMLV-IMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKR 128
               L+ G   M   + DPD  K +L ++      +   L    ++   L   +  +WK+
Sbjct: 78  CAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILE--SWVGRGLVTLDGSKWKK 135

Query: 129 IRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTL 188
            R ++ P F     K  + ++S+   M++    +    +  + L       T+D I    
Sbjct: 136 HRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCA 195

Query: 189 FG----VNLDSLNNPQDPFLKNMKKLLKLDF--LDPFLL---LISLFPFLTPVFEALNIG 239
           F     + LDS     D +LK +  L K+    ++ FL    L+  F     +F   N  
Sbjct: 196 FSHQGSIQLDST---LDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFN-- 250

Query: 240 LFPKDVTHFLKNSIERMKESRLKDK------QKHRVDFFQQMIDSQNSKETKSHKALSDL 293
              +++  F +  I+  KES LKDK      QK R DF   ++    S ++++ K  S+ 
Sbjct: 251 ---QELHQFTEKVIQDRKES-LKDKLKQDTTQKRRWDFLDILL----SAKSENTKDFSEA 302

Query: 294 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQM 353
           +L A+    +FA +DTTS+ + +I+Y LA +P+ QQ+ ++EI  +L + + +T++ L QM
Sbjct: 303 DLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQM 362

Query: 354 EYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPE 412
            Y  M + E LRL+  V  ++R+  K I   +G  +P G+ V + I+ALHH+P +W +P+
Sbjct: 363 PYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQ 422

Query: 413 KFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQ 472
            F P RFS++N + I  Y +IPF AG RNCIG  FA+   K+AV   L  F   P     
Sbjct: 423 VFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAP----- 477

Query: 473 IPLKLDNLPILQPEKPIVLK 492
                D+    QP + +VLK
Sbjct: 478 -----DHSRPPQPVRQVVLK 492


>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
           [Homo sapiens]
          Length = 509

 Score =  167 bits (424), Expect = 2e-41
 Identities = 128/469 (27%), Positives = 224/469 (47%), Gaps = 22/469 (4%)

Query: 39  PGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQ-QPMLVIMDPDMIKTVLVKE 97
           P P    FLG   F          E  EKY   +  + G  Q    I DPD  KT+L + 
Sbjct: 47  PAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRT 106

Query: 98  CYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLV 157
                  Q    P+  L   L+  +  +W + R LL+P F     K  + +++    M++
Sbjct: 107 DPKSQYLQKFSPPL--LGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMML 164

Query: 158 RSLRQEAENSK-SINLKDFFGAYTMDVITGTLFGVNLD-SLNNPQDPFLKNMKKLLKLDF 215
               +       S+ + +   + ++D+I    F    +   N+  DP+ K + +L K+ F
Sbjct: 165 DKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIF 224

Query: 216 LDPFLLLI--SLFPFLTPV---FEALN--IGLFPKDVTHFLKNSIERMKESRLKDKQKHR 268
              + LL    +   L+P    F+ L+  +  +   +    K S++   +     K+K  
Sbjct: 225 HRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRK-- 282

Query: 269 VDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQ 328
              +Q  +D   S + +S  + SD+++ ++    + A +DT + ++ +I+Y LA +P+ Q
Sbjct: 283 ---YQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQ 339

Query: 329 QKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVF 387
           ++ +EE+  +L + + +T+D L +M Y  M + ET RL P V  ++R   K +   +G  
Sbjct: 340 ERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCT 399

Query: 388 IPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRF 447
           +P G+ V++ I+ LHH+P  W  P+ F P RFS++N D    Y Y+PF AG RNCIG  F
Sbjct: 400 LPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEF 459

Query: 448 ALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLR 496
           A+  +K+ +   L +F   P  +   PL   N  IL+P+  + L  HL+
Sbjct: 460 AMIELKVTIALILLHFRVTP--DPTRPLTFPNHFILKPKNGMYL--HLK 504


>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
           [Homo sapiens]
          Length = 531

 Score =  166 bits (419), Expect = 6e-41
 Identities = 122/431 (28%), Positives = 214/431 (49%), Gaps = 28/431 (6%)

Query: 80  PMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMG-FLKSALSFAEDEEWKRIRTLLSPAFT 138
           P+LV++ PD IK +L         + +  G +  +L   L  ++ ++W R R LL+PAF 
Sbjct: 105 PLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFH 164

Query: 139 SVKFKEMVPIISQCGDMLVRSLRQEAENSK-SINLKDFFGAYTMDVITGTLFGVNLDSLN 197
               K  + I +Q  D++    R  AE S  S+++ +     T+D +   +F  N    +
Sbjct: 165 FDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYN----S 220

Query: 198 NPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD----VTHFLKNSI 253
           N Q+     +  +++L  L        L  +L  ++     G   +     V HF    I
Sbjct: 221 NCQEKMSDYISAIIELSALS-VRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVI 279

Query: 254 ERMK--------ESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFA 305
           +  +        E+ LK KQ   +DF   ++ +++    +  K LSD ++ A++   +F 
Sbjct: 280 QERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARD----EDGKELSDEDIRAEADTFMFE 335

Query: 306 AYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKA--PVTYDALVQMEYLDMVVNET 363
            +DTTS+ + ++++ LA +P+ Q+K +EEI  V+  +    + +D L Q+ +  M + E+
Sbjct: 336 GHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKES 395

Query: 364 LRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKK 422
           LR +P V+ V+R C +DI++ +G  IPKG+  +V IY  HH+P  W + + + P RF   
Sbjct: 396 LRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPD 455

Query: 423 NKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPI 482
           N        Y+PF AGPRNCIG  FA+  +++ V   L  F     +  ++  K +   I
Sbjct: 456 NPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPE--LI 513

Query: 483 LQPEKPIVLKV 493
           L+ E  + LKV
Sbjct: 514 LRTENGLWLKV 524


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  162 bits (410), Expect = 7e-40
 Identities = 121/461 (26%), Positives = 222/461 (48%), Gaps = 44/461 (9%)

Query: 63  ECNEKYGEM--WGLYEGQQPMLVIMDPDMIKTVLVK----ECYSVFTNQMPLGPMGFLKS 116
           E  E+Y  M    L+ G  PM+ + + + ++ +L      +  S++    P   +G L S
Sbjct: 79  EYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTS 138

Query: 117 ALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFF 176
                   +W+  R +L+P F     ++ + I+++  ++LV+ L +   N ++ N   + 
Sbjct: 139 T-----GNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHI-NQEAFNCFFYI 192

Query: 177 GAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLD---PFLLLISLFPFLTPVF 233
               +D+I  T  G N+ + +N    +++ + ++ ++ F     P+L L   +      +
Sbjct: 193 TLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGW 252

Query: 234 EALNIGLFPKDVTHFLKNSI--ERMKESRL--------------KDKQKHRVDFFQQMID 277
           E          + H   NS+  ER  E                 K+K++  +D    + D
Sbjct: 253 EHKK----SLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTD 308

Query: 278 SQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDA 337
            + ++       LS  ++  +    +F  +DTT+  + + +Y L ++P+VQ+K+  E+D 
Sbjct: 309 DEGNR-------LSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDD 361

Query: 338 VL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMV 396
           V   +  P T + L ++ YL+ V+ ETLRLFP V    R   +D E+ G  + KG   ++
Sbjct: 362 VFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVI 421

Query: 397 PIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAV 456
             YALH DP+Y+  PE+F PERF  +N      Y Y+PF AGPRNCIG +FA+   K  +
Sbjct: 422 IPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTIL 481

Query: 457 IRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRD 497
              L++F  +  ++ +  L L+   IL+P   I +K+  R+
Sbjct: 482 SCILRHFWIESNQKRE-ELGLEGQLILRPSNGIWIKLKRRN 521


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score =  156 bits (394), Expect = 5e-38
 Identities = 106/407 (26%), Positives = 194/407 (47%), Gaps = 29/407 (7%)

Query: 80  PMLVIMDPDMIKTVL-----VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLS 134
           P++ +  PD++++V+     + +   VF   +      +L   L  +  ++W+  R LL+
Sbjct: 97  PIINLCHPDIVRSVINTSDAITDKDIVFYKTLK----PWLGDGLLLSVGDKWRHHRRLLT 152

Query: 135 PAFTSVKFKEMVPIISQCGDML-VRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNL 193
           PAF     K  + I S+  +++  +  R   E S  +++ +     T+D +   +F  + 
Sbjct: 153 PAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDS 212

Query: 194 DSLNNPQDPFLKNMK-KLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNS 252
           +    P +     M+   L +   + F        FLTP     +           + + 
Sbjct: 213 NCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFH------RACRLVHDF 266

Query: 253 IERMKESRLKDKQKHRVDFFQQ---------MIDSQNSKETKSHKALSDLELVAQSIIII 303
            + + + R +      VD F Q          ID     E K+ K LSD ++ A++   +
Sbjct: 267 TDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFM 326

Query: 304 FAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP--VTYDALVQMEYLDMVVN 361
           F  +DTT++ L +++Y LA HP+ Q++ ++E+  +L ++ P  + +D L Q+ +L M + 
Sbjct: 327 FGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLK 386

Query: 362 ETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS 420
           E+LRL P +    R C +D+ + +   IPKG    + I+A+HH+P  W +PE + P RF 
Sbjct: 387 ESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFD 446

Query: 421 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKP 467
            +N        +IPF AGPRNCIG +FA+  +K+ +   L  F   P
Sbjct: 447 PENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILP 493


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  155 bits (392), Expect = 8e-38
 Identities = 114/415 (27%), Positives = 201/415 (48%), Gaps = 45/415 (10%)

Query: 80  PMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLK----SALSFAEDEEWKRIRTLLSP 135
           P+L++  PD+I+ +      +V    M     GFLK      L  +  ++W R R +L+P
Sbjct: 97  PLLILCHPDIIRPITSASA-AVAPKDMIF--YGFLKPWLGDGLLLSGGDKWSRHRRMLTP 153

Query: 136 AFTSVKFKEMVPIISQCGDMLV-RSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLD 194
           AF     K  + I ++  +++  +  R  +E S  +++ +     T+D +   +F    +
Sbjct: 154 AFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESN 213

Query: 195 SLNNPQDPFL-----------KNMKKLLKLDFL-------DPFLLLISLF-PFLTPVFEA 235
               P +              +N + LL  DFL         F     L   F   V + 
Sbjct: 214 CQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQE 273

Query: 236 LNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLEL 295
               L  + +  FLKN          K K K  +DF   ++ S++    +  K LSD ++
Sbjct: 274 RRCTLPTQGIDDFLKN----------KAKSK-TLDFIDVLLLSKD----EDGKELSDEDI 318

Query: 296 VAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVT--YDALVQM 353
            A++   +F  +DTT++ L +++Y LA HP+ Q++ ++E+  +L ++ P+   +D L Q+
Sbjct: 319 RAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQL 378

Query: 354 EYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPE 412
            +L M + E+LRL P V  ++R C +D  + +G  IPKG+  ++ I  +H++P  W +PE
Sbjct: 379 PFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPE 438

Query: 413 KFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKP 467
            + P RF ++N        +IPF AGPRNCIG  FA+  +K+ +   L +F   P
Sbjct: 439 VYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILP 493


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  155 bits (392), Expect = 8e-38
 Identities = 114/415 (27%), Positives = 201/415 (48%), Gaps = 45/415 (10%)

Query: 80  PMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLK----SALSFAEDEEWKRIRTLLSP 135
           P+L++  PD+I+ +      +V    M     GFLK      L  +  ++W R R +L+P
Sbjct: 97  PLLILCHPDIIRPITSASA-AVAPKDMIF--YGFLKPWLGDGLLLSGGDKWSRHRRMLTP 153

Query: 136 AFTSVKFKEMVPIISQCGDMLV-RSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLD 194
           AF     K  + I ++  +++  +  R  +E S  +++ +     T+D +   +F    +
Sbjct: 154 AFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESN 213

Query: 195 SLNNPQDPFL-----------KNMKKLLKLDFL-------DPFLLLISLF-PFLTPVFEA 235
               P +              +N + LL  DFL         F     L   F   V + 
Sbjct: 214 CQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQE 273

Query: 236 LNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLEL 295
               L  + +  FLKN          K K K  +DF   ++ S++    +  K LSD ++
Sbjct: 274 RRCTLPTQGIDDFLKN----------KAKSK-TLDFIDVLLLSKD----EDGKELSDEDI 318

Query: 296 VAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVT--YDALVQM 353
            A++   +F  +DTT++ L +++Y LA HP+ Q++ ++E+  +L ++ P+   +D L Q+
Sbjct: 319 RAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQL 378

Query: 354 EYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPE 412
            +L M + E+LRL P V  ++R C +D  + +G  IPKG+  ++ I  +H++P  W +PE
Sbjct: 379 PFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPE 438

Query: 413 KFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKP 467
            + P RF ++N        +IPF AGPRNCIG  FA+  +K+ +   L +F   P
Sbjct: 439 VYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILP 493


>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
           [Homo sapiens]
          Length = 520

 Score =  155 bits (391), Expect = 1e-37
 Identities = 114/420 (27%), Positives = 200/420 (47%), Gaps = 30/420 (7%)

Query: 68  YGEMWGLYEGQQPMLV-IMDPDMIKTVLVKECYSVFTNQMPLGPMG-FLKSALSFAEDEE 125
           +G+M   + G    +V I  P  IK VL      V  +++    +  +L   L  +  E+
Sbjct: 84  FGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEK 143

Query: 126 WKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEA-ENSKSINLKDFFGAYTMDVI 184
           W R R +L+PAF     K  + I ++  +++    +  A E S  +++ +     T+D +
Sbjct: 144 WSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSL 203

Query: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFL-----DPFLLLISLFPFLTPVFEALNIG 239
              +F  +      P +     +  +L+L  L        LL I    +LTP  +     
Sbjct: 204 QKCVFSFDSHCQEKPSE----YIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRF--- 256

Query: 240 LFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQ---------MIDSQNSKETKSHKAL 290
              +     + +  + + + R +      VD F Q          ID     + +  K L
Sbjct: 257 ---RRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKL 313

Query: 291 SDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP--VTYD 348
           SD ++ A++   +F  +DTT++ L +++Y LA HP+ Q++ ++E+  +L ++ P  + +D
Sbjct: 314 SDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWD 373

Query: 349 ALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKY 407
            L Q+ +L M + E+LRL P V  V+R C +DI + +G  IPKG+  ++ ++  HH+P  
Sbjct: 374 DLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAV 433

Query: 408 WTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKP 467
           W +PE + P RF  KN        +IPF AGPRNCIG  FA+  +K+ +   L  F   P
Sbjct: 434 WPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLP 493


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score =  155 bits (391), Expect = 1e-37
 Identities = 104/404 (25%), Positives = 199/404 (49%), Gaps = 23/404 (5%)

Query: 80  PMLVIMDPDMIKTVL-VKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFT 138
           P +V+  PD I+++       +   N        +L   +  +  ++W R R +L+PAF 
Sbjct: 97  PFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFH 156

Query: 139 SVKFKEMVPIISQCGDMLVRSLRQEA-ENSKSINLKDFFGAYTMDVITGTLFGVNLDSLN 197
               K  + I ++  ++++   +  A E S  +++ +     T+D +   +F  +     
Sbjct: 157 FNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQE 216

Query: 198 NPQDPFLKNMKKLLKLDFLDPFLLL-ISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERM 256
            P +     ++    ++     +L  +    +L+      +       + H   +++ R 
Sbjct: 217 RPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRAC---RLVHDFTDAVIRE 273

Query: 257 KESRL---------KDKQKHR-VDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAA 306
           +   L         KDK K + +DF   ++ S++    +  KALSD ++ A++   +F  
Sbjct: 274 RRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKD----EDGKALSDEDIRAEADTFMFGG 329

Query: 307 YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP--VTYDALVQMEYLDMVVNETL 364
           +DTT++ L +++Y LA HP+ Q++ ++E+  +L ++ P  + +D L Q+ +L M V E+L
Sbjct: 330 HDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESL 389

Query: 365 RLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKN 423
           RL P    ++R C +DI + +G  IPKG+  ++ I  +HH+P  W +PE + P RF  +N
Sbjct: 390 RLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPEN 449

Query: 424 KDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKP 467
                   +IPF AGPRNCIG  FA+  +K+ +   L +F F P
Sbjct: 450 SKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLP 493


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score =  145 bits (367), Expect = 6e-35
 Identities = 104/407 (25%), Positives = 194/407 (47%), Gaps = 29/407 (7%)

Query: 80  PMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMG-FLKSALSFAEDEEWKRIRTLLSPAFT 138
           P+L +  PD+I++V+         ++     +  +L   L  +  ++W R R +L+PAF 
Sbjct: 97  PLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFH 156

Query: 139 SVKFKEMVPIISQCGDMLVRSLRQEA-ENSKSINLKDFFGAYTMDVITGTLFGVNLDSLN 197
               K  + I ++  +++    +  A E S  +++ +     T+D +   +F  +     
Sbjct: 157 FNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQE 216

Query: 198 NPQDPFLKNMKKLLKLDFL-----DPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNS 252
            P +     +  +L+L  L        LL I    +LTP  +        +     + + 
Sbjct: 217 KPSE----YIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRF------RRACRLVHDF 266

Query: 253 IERMKESRLKDKQKHRVDFFQQ---------MIDSQNSKETKSHKALSDLELVAQSIIII 303
            + + + R +      VD F Q          ID     + +  K LSD ++ A++   +
Sbjct: 267 TDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFM 326

Query: 304 FAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAP--VTYDALVQMEYLDMVVN 361
           F  +DTT++ L +++Y LA HP+ Q++ ++E+  +L ++ P  + +D L  + +L M + 
Sbjct: 327 FEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMK 386

Query: 362 ETLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS 420
           E+LRL P V  ++R   +DI + +G  IPKG+  ++ ++  HH+P  W +PE + P RF 
Sbjct: 387 ESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFD 446

Query: 421 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKP 467
            +N        +IPF AGPRNCIG  FA+  +K+ +   L  F   P
Sbjct: 447 PENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLP 493


>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
           [Homo sapiens]
          Length = 519

 Score =  144 bits (364), Expect = 1e-34
 Identities = 109/432 (25%), Positives = 207/432 (47%), Gaps = 32/432 (7%)

Query: 77  GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPA 136
           G +  + + DPD +K +L +       +   L P  ++   L     + W + R +L+PA
Sbjct: 92  GGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAP--WIGYGLLLLNGQTWFQHRRMLTPA 149

Query: 137 FTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG----VN 192
           F     K  V +++    +++    +       + +       T+D I    F     + 
Sbjct: 150 FHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQ 209

Query: 193 LDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPK---DVTHFL 249
           +D  +      + ++  L+       F  + + F     ++   + G +      + H  
Sbjct: 210 VDRNSQSYIQAISDLNNLV-------FSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQH 262

Query: 250 KNSIERMKESRL-------KDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIII 302
            + + ++++++L       K K+K  +DF   ++ ++     ++   LSD +L A+    
Sbjct: 263 TDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEVDTF 318

Query: 303 IFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNE 362
           +F  +DTT++ + +I+Y LATHP  Q++ +EEI ++L + A +T++ L QM Y  M + E
Sbjct: 319 MFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKE 378

Query: 363 TLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421
            LRL+P V  + R     +   +G  +PKG+ V++ IY LHH+PK W  PE F P RF+ 
Sbjct: 379 ALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAP 438

Query: 422 KNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 481
            +      + ++PF  G RNCIG +FA+  +K+A    L  F   P   T+IP+ +  L 
Sbjct: 439 GSAQ--HSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP-DPTRIPIPIARL- 494

Query: 482 ILQPEKPIVLKV 493
           +L+ +  I L++
Sbjct: 495 VLKSKNGIHLRL 506


>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform a [Homo sapiens]
          Length = 512

 Score =  143 bits (360), Expect = 4e-34
 Identities = 107/422 (25%), Positives = 198/422 (46%), Gaps = 45/422 (10%)

Query: 82  LVIMDPDMIKTVLVK------ECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSP 135
           L I +PD  K V  +      + Y  F   +  G        L   E  +W + R LL+P
Sbjct: 92  LNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRG--------LLVLEGPKWLQHRKLLTP 143

Query: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDS 195
            F     K  V + ++   +++    ++A   KS ++    G   ++ +    FG     
Sbjct: 144 GFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTG 203

Query: 196 LNNPQDPF---------LKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVT 246
           L + +D           L   ++L+   + + F+       +LTP        L    V 
Sbjct: 204 LGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIY------WLTPHGRRF---LRACQVA 254

Query: 247 HFLKNSIERMKESRLKDKQ-------KHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS 299
           H   + + R +++ L+D++       +  +DF   ++ +++  + K    LSD +L A+ 
Sbjct: 255 HDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK----LSDADLRAEV 310

Query: 300 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMV 359
              +F  +DTT++ + + +Y +A +P+ Q + +EE+  +L ++    +D L +M YL M 
Sbjct: 311 DTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMC 370

Query: 360 VNETLRLFPVVSRVTRVCKKDIE-INGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418
           + E+ RL+P V +V R   K +  ++G  +P G  + + IYALH +   W +PE F   R
Sbjct: 371 IKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLR 430

Query: 419 FSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLD 478
           FS +N      + ++PF AGPRNCIG +FA++ +K+     L  F F     +++P+K+ 
Sbjct: 431 FSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFS-LDPSRLPIKMP 489

Query: 479 NL 480
            L
Sbjct: 490 QL 491


>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
           [Homo sapiens]
          Length = 519

 Score =  142 bits (359), Expect = 5e-34
 Identities = 108/432 (25%), Positives = 206/432 (47%), Gaps = 32/432 (7%)

Query: 77  GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPA 136
           G +  + + DPD +K +L +       +   L P   +   L     + W + R +L+PA
Sbjct: 92  GGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPR--IGYGLLLLNGQTWFQHRRMLTPA 149

Query: 137 FTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFG----VN 192
           F +   K  V +++    +++    +       + +       T+D I  + F     + 
Sbjct: 150 FHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQ 209

Query: 193 LDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPK---DVTHFL 249
           +D  +      + ++  L+       F  + + F     ++   + G +      + H  
Sbjct: 210 VDRNSQSYIQAISDLNSLV-------FCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQH 262

Query: 250 KNSIERMKESRL-------KDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIII 302
            + + ++++++L       K K+K  +DF   ++ ++     ++   LSD +L A+    
Sbjct: 263 TDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEVDTF 318

Query: 303 IFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNE 362
           +F  +DTT++ + +I+Y LATHP  Q++ +EEI  +L + A +T++ L QM Y  M + E
Sbjct: 319 MFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKE 378

Query: 363 TLRLFPVVSRVTRVCKKDIEI-NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421
            LRL+P V  + R     +   +G  +PKG+ V++ IY LHH+PK W   E F P RF+ 
Sbjct: 379 ALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAP 438

Query: 422 KNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 481
            +      + ++PF  G RNCIG +FA+  +K+A    L  F   P   T+IP+ +  L 
Sbjct: 439 GSAQ--HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLP-DPTRIPIPMARL- 494

Query: 482 ILQPEKPIVLKV 493
           +L+ +  I L++
Sbjct: 495 VLKSKNGIHLRL 506


>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform b [Homo sapiens]
          Length = 511

 Score =  142 bits (358), Expect = 7e-34
 Identities = 106/421 (25%), Positives = 197/421 (46%), Gaps = 44/421 (10%)

Query: 82  LVIMDPDMIKTVLVK------ECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSP 135
           L I +PD  K V  +      + Y  F   +  G        L   E  +W + R LL+P
Sbjct: 92  LNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRG--------LLVLEGPKWLQHRKLLTP 143

Query: 136 AFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDS 195
            F     K  V + ++   +++    ++A   KS ++    G   ++ +    FG     
Sbjct: 144 GFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTG 203

Query: 196 LNNPQDPF--------LKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTH 247
           L +    +        L   ++L+   + + F+       +LTP        L    V H
Sbjct: 204 LGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIY------WLTPHGRRF---LRACQVAH 254

Query: 248 FLKNSIERMKESRLKDKQ-------KHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300
              + + R +++ L+D++       +  +DF   ++ +++  + K    LSD +L A+  
Sbjct: 255 DHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK----LSDADLRAEVD 310

Query: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360
             +F  +DTT++ + + +Y +A +P+ Q + +EE+  +L ++    +D L +M YL M +
Sbjct: 311 TFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCI 370

Query: 361 NETLRLFPVVSRVTRVCKKDIE-INGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERF 419
            E+ RL+P V +V R   K +  ++G  +P G  + + IYALH +   W +PE F   RF
Sbjct: 371 KESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRF 430

Query: 420 SKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDN 479
           S +N      + ++PF AGPRNCIG +FA++ +K+     L  F F     +++P+K+  
Sbjct: 431 STENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFS-LDPSRLPIKMPQ 489

Query: 480 L 480
           L
Sbjct: 490 L 490


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  129 bits (325), Expect = 5e-30
 Identities = 113/452 (25%), Positives = 205/452 (45%), Gaps = 28/452 (6%)

Query: 39  PGPTPLPFLGTILFYLRGLWNFDRECN---EKYGEMWGLYEGQQPMLVIMDPDMIKTVLV 95
           PGP  LPFLG   F+L        E     +KYG ++ L  G    ++I    +IK  L+
Sbjct: 45  PGPWRLPFLGN--FFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALI 102

Query: 96  KECYSVFTNQMPLGPMG---FLKSALSFAEDEEWKRIRTLLSPAFTSVKF--KEMVPIIS 150
               + F N+ P+ PM    F K+ L  +  + WK  R     A  +     K +   I 
Sbjct: 103 HMDQN-FGNR-PVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQ 160

Query: 151 QCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKL 210
           +    L  ++++E  N +  +          ++I    FG   +     QD + + + KL
Sbjct: 161 EEAQHLTEAIKEE--NGQPFDPHFKINNAVSNIICSITFGERFEY----QDSWFQQLLKL 214

Query: 211 L-KLDFLDPFLL--LISLFPFLTPVFEALNIGLFP--KDVTHFLKNSIERMKESRLKDKQ 265
           L ++ +L+      L ++FP++       +  LF   K +  F+ + I++ ++     + 
Sbjct: 215 LDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAET 274

Query: 266 KHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHP 325
           +  +D + + +       T S     +  L+  ++ + FA  +TTSTTL + +  +A +P
Sbjct: 275 RDFIDAYLKEMSKHTGNPTSS---FHEENLICSTLDLFFAGTETTSTTLRWALLYMALYP 331

Query: 326 DVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVS-RVTRVCKKDIEIN 384
           ++Q+K+Q EID V+      +  A   M Y + V++E  R+  ++   V R    D  + 
Sbjct: 332 EIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLA 391

Query: 385 GVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIG 444
           G  +PKG  ++  + ALH DP  W  P+ F P+ F  +N        ++PF  G R C+G
Sbjct: 392 GYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHF-LENGQFKKREAFMPFSIGKRACLG 450

Query: 445 MRFALTNIKLAVIRALQNFSFKPCKETQIPLK 476
            + A T + +     +Q F+F+P    ++ LK
Sbjct: 451 EQLARTELFIFFTSLMQKFTFRPPNNEKLSLK 482


>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
          Length = 500

 Score =  128 bits (322), Expect = 1e-29
 Identities = 107/470 (22%), Positives = 207/470 (44%), Gaps = 36/470 (7%)

Query: 13  VLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDR---------- 62
           VL+A  L   +++   S    +   IPGP    FL   L +L   W  D           
Sbjct: 12  VLLAFGLCCTFVHRARS----RYEHIPGPPRPSFL---LGHLPCFWKKDEVGGRVLQDVF 64

Query: 63  -ECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTN-----QMPLGPMGFLKS 116
            +  +KYG +  +    +  +++  P+ +K  L+   Y+  +      Q   G   F + 
Sbjct: 65  LDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQG 124

Query: 117 ALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFF 176
            +S    E W + R ++  AF+      ++   ++  + LV  L  +A+    ++++D  
Sbjct: 125 LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDML 184

Query: 177 GAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEAL 236
               MD++    FG+    L   Q P  + +K +L+        L   L      + E  
Sbjct: 185 TYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVR 244

Query: 237 NIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELV 296
               F + V    ++ ++R +E+ LK  ++   D   Q++ ++         A  D  L+
Sbjct: 245 ESIRFLRQVG---RDWVQRRREA-LKRGEEVPADILTQILKAEEG-------AQDDEGLL 293

Query: 297 AQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYL 356
              +    A ++T++  L F + EL+  P++  +LQ E+D V+ +K  + ++ L +++YL
Sbjct: 294 DNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYL 353

Query: 357 DMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCP 416
             V+ E+LRL+P      R+ +++  I+GV +P    ++   Y +     Y+ +P  F P
Sbjct: 354 SQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNP 413

Query: 417 ERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFK 466
           +RF          + Y PF  G R+CIG +FA   +K+ + + LQ   F+
Sbjct: 414 DRFGPGAPK--PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR 461


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  128 bits (321), Expect = 1e-29
 Identities = 123/482 (25%), Positives = 221/482 (45%), Gaps = 27/482 (5%)

Query: 13  VLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEM 71
           VL  + L+LL ++   S +   KL  PGPTPLP +G IL   ++ +       ++ YG +
Sbjct: 8   VLCLSCLLLLSLWRQSSGR--GKLP-PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPV 64

Query: 72  WGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQ--MPLGPMGFLKSALSFAEDEEWKRI 129
           + LY G +P++V+   + +K  L+ +    F+ +   PL         + F+  ++WK I
Sbjct: 65  FTLYFGLKPIVVLHGYEAVKEALI-DLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEI 123

Query: 130 R-----TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
           R     TL +        ++ V   ++C   LV  LR+    +   +     G    +VI
Sbjct: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARC---LVEELRKT--KASPCDPTFILGCAPCNVI 178

Query: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD 244
              +F    D  +      ++ + + +K+    P++ + + F  +   F   +  L  K+
Sbjct: 179 CSIIFHKRFDYKDQQFLNLMEKLNENIKI-LSSPWIQICNNFSPIIDYFPGTHNKLL-KN 236

Query: 245 VTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIF 304
           V       +E++KE +      +  DF    +  +  KE  +  +   +E +  + + +F
Sbjct: 237 VAFMKSYILEKVKEHQESMDMNNPQDFIDCFL-MKMEKEKHNQPSEFTIESLENTAVDLF 295

Query: 305 AA-YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP-NKAPVTYDALVQMEYLDMVVNE 362
            A  +TTSTTL + +  L  HP+V  K+QEEI+ V+  N++P   D    M Y D VV+E
Sbjct: 296 GAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRS-HMPYTDAVVHE 354

Query: 363 TLRLFPVV-SRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421
             R   ++ + +      DI+     IPKG  +++ + ++ HD K +  PE F P  F  
Sbjct: 355 VQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLD 414

Query: 422 KNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 481
           +  +      ++PF AG R C+G   A   + L +   LQNF+ K   +   P  LD  P
Sbjct: 415 EGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVD---PKNLDTTP 471

Query: 482 IL 483
           ++
Sbjct: 472 VV 473


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  127 bits (319), Expect = 2e-29
 Identities = 125/483 (25%), Positives = 218/483 (45%), Gaps = 29/483 (6%)

Query: 13  VLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEM 71
           VL  + L+LL I+   S +   KL  PGPTPLP +G IL   ++ +       ++ YG +
Sbjct: 8   VLCLSCLLLLSIWRQSSGR--GKLP-PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64

Query: 72  WGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQ--MPLGPMGFLKSALSFAEDEEWKRI 129
           + LY G + M+V+   +++K  L+ +    F+ +   PL         + F+  + WK I
Sbjct: 65  FTLYFGLERMVVLHGYEVVKEALI-DLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEI 123

Query: 130 R-----TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184
           R     TL +        ++ V   ++C   LV  LR+    +   +     G    +VI
Sbjct: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARC---LVEELRKT--KASPCDPTFILGCAPCNVI 178

Query: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFL--DPFLLLISLFPFLTPVFEALNIGLFP 242
              +F    D  +     FL  M+KL +   +   P++ + + FP +   F   +  L  
Sbjct: 179 CSIIFQKRFDYKDQQ---FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLL- 234

Query: 243 KDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIII 302
           K++     + +E++KE +      +  DF    +     ++       +   LV  +  +
Sbjct: 235 KNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADL 294

Query: 303 IFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP-NKAPVTYDALVQMEYLDMVVN 361
           + A  +TTSTTL + +  L  HP+V  K+QEEI+ V+  N++P   D    M Y D VV+
Sbjct: 295 LGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR-GHMPYTDAVVH 353

Query: 362 ETLRLFPVV-SRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS 420
           E  R   ++ + +      D++     IPKG  ++  + ++ HD K +  PE F P  F 
Sbjct: 354 EVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 413

Query: 421 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 480
            +  +      ++PF AG R C+G   A   + L +   LQNF+ K   +   P  LD  
Sbjct: 414 DEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID---PKDLDTT 470

Query: 481 PIL 483
           P++
Sbjct: 471 PVV 473


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  124 bits (312), Expect = 2e-28
 Identities = 113/446 (25%), Positives = 199/446 (44%), Gaps = 39/446 (8%)

Query: 39  PGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKE 97
           PGP PLP LG +L    RGL        EKYG+++ ++ G +P++++   + I+  LV +
Sbjct: 32  PGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDK 91

Query: 98  CYSVFTNQMPLGPMG--FLKSALSFAEDEEWKRIR-----TLLSPAFTSVKFKEMVPIIS 150
               F+ +  +  +   F    + FA    WK +R     T+          +E +   +
Sbjct: 92  A-EAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEA 150

Query: 151 QCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKL 210
           QC   L+  LR+       ++    F + T ++I   +FG       + QD   +   K+
Sbjct: 151 QC---LIEELRKS--KGALMDPTFLFQSITANIICSIVFGKRF----HYQD---QEFLKM 198

Query: 211 LKLDFLDPFLLLISLFPFLTPVFEALNIGLFP----------KDVTHFLKNSIERMKESR 260
           L L F   F L+ S+F  L  +F    +  FP          +++  ++ +S+E+ +E+ 
Sbjct: 199 LNL-FYQTFSLISSVFGQLFELFSGF-LKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL 256

Query: 261 LKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYE 320
                K  +D +   ++ + S    +H   S   L   ++ + FA  +TTSTTL +    
Sbjct: 257 DPSAPKDLIDTYLLHMEKEKSN---AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLL 313

Query: 321 LATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSR-VTRVCK 378
           +  +P V +++  EI+ V+ P++ P  +D   +M Y + V+ E  R   ++   V  +  
Sbjct: 314 MLKYPHVAERVYREIEQVIGPHRPPELHDR-AKMPYTEAVIYEIQRFSDLLPMGVPHIVT 372

Query: 379 KDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAG 438
           +     G  IPK   V + +    HDP Y+ +P+ F P+ F   N        +IPF  G
Sbjct: 373 QHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLG 432

Query: 439 PRNCIGMRFALTNIKLAVIRALQNFS 464
            R C+G   A   + L     LQNFS
Sbjct: 433 KRICLGEGIARAELFLFFTTILQNFS 458


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  122 bits (307), Expect = 6e-28
 Identities = 83/298 (27%), Positives = 151/298 (50%), Gaps = 8/298 (2%)

Query: 182 DVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFL--TPVFEALNIG 239
           ++I    FG   D  N+     L  M + L++  L+  +LL+++ P+L   P      + 
Sbjct: 230 NIICSLCFGQRFDYTNSEFKKMLGFMSRGLEI-CLNSQVLLVNICPWLYYLPFGPFKELR 288

Query: 240 LFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS 299
              KD+T FLK  I+  +ES  ++  +  +D +  ++  +  ++  S+ +  +  L    
Sbjct: 289 QIEKDITSFLKKIIKDHQESLDRENPQDFIDMY--LLHMEEERKNNSNSSFDEEYLFYII 346

Query: 300 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDM 358
             +  A  DTT+ +L + +  ++ +PDVQ+K+ EEI+ V+  N+AP   D   QM Y + 
Sbjct: 347 GDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDK-AQMPYTEA 405

Query: 359 VVNETLRLFPVVS-RVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE 417
            + E  RL  VV   +  +  ++  + G  IPKG  ++  ++++H DP  W +PE F P 
Sbjct: 406 TIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPN 465

Query: 418 RFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPL 475
           RF       I    +IPFG G R C+G + A   + L  +  +Q+F+F   ++++ PL
Sbjct: 466 RFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPL 523


>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
           [Homo sapiens]
          Length = 372

 Score =  121 bits (304), Expect = 1e-27
 Identities = 105/359 (29%), Positives = 175/359 (48%), Gaps = 39/359 (10%)

Query: 132 LLSPAFTSVKFKEMVPIISQCGDMLVRS--LRQEAENSKSI-NLKDFFGAYTMDVITGTL 188
           +L P   ++   E+  +I+   D++ R   LR +AE+ +++ N+ D F  Y+M+ +   L
Sbjct: 9   ILKPKDVAIYSGEVNQVIA---DLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATIL 65

Query: 189 FGVNLDSLNN--PQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVT 246
           +   L  L N  PQ          L +++++   L+ S+F        ++  G  P+ + 
Sbjct: 66  YESRLGCLENSIPQ----------LTVEYIEALELMFSMFK------TSMYAGAIPRWLR 109

Query: 247 HFLKNSIE---RMKESRLKDKQKHRVDFFQQMIDSQNSKETKSH----------KALSDL 293
            F+        R  +   K  Q H VD   + I  Q  +  +            +AL+  
Sbjct: 110 PFIPKPWREFCRSWDGLFKFSQIH-VDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQ 168

Query: 294 ELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQM 353
           E+ A    ++ A  DTTS TL + +Y LA HP+VQQ +  EI   L  +   T   + ++
Sbjct: 169 EIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKV 228

Query: 354 EYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEK 413
             +  ++ ETLRLFPV+    RV ++D+ I G  IPKG  + +  YA  +  + +   ++
Sbjct: 229 PLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKE 288

Query: 414 FCPERFSKK-NKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKET 471
           F PER+ +K + D +D +  IPFG G R+CIG R A   I L VI+ LQ+F  K   +T
Sbjct: 289 FRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQT 347


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.140    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,418,162
Number of Sequences: 37866
Number of extensions: 799501
Number of successful extensions: 2155
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1919
Number of HSP's gapped (non-prelim): 102
length of query: 503
length of database: 18,247,518
effective HSP length: 107
effective length of query: 396
effective length of database: 14,195,856
effective search space: 5621558976
effective search space used: 5621558976
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.