Guide to the Human Genome
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Search of human proteins with 111118992

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo
sapiens]
         (466 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]    946   0.0  
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]    865   0.0  
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]    858   0.0  
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]    858   0.0  
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]                453   e-127
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]                433   e-121
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]   221   1e-57
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]   220   2e-57
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]    220   2e-57
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap...   218   1e-56
gi|4557265 beta-1-adrenergic receptor [Homo sapiens]                  212   5e-55
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]      211   1e-54
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa...   210   3e-54
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap...   209   4e-54
gi|4503383 dopamine receptor D1 [Homo sapiens]                        207   2e-53
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]               202   7e-52
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap...   201   9e-52
gi|4503391 dopamine receptor D5 [Homo sapiens]                        201   1e-51
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]           201   2e-51
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]            201   2e-51
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]             198   8e-51
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]            194   1e-49
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]             188   8e-48
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]         178   1e-44
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]         177   2e-44
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]         174   1e-43
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]         174   1e-43
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]         174   1e-43
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]         174   1e-43
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]         174   1e-43

>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
          Length = 466

 Score =  946 bits (2445), Expect = 0.0
 Identities = 466/466 (100%), Positives = 466/466 (100%)

Query: 1   MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60
           MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
Sbjct: 1   MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60

Query: 61  THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120
           THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
Sbjct: 61  THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120

Query: 121 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE 180
           SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
Sbjct: 121 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE 180

Query: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN 240
           EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
Sbjct: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN 240

Query: 241 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD 300
           APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
Sbjct: 241 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD 300

Query: 301 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL 360
           FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
Sbjct: 301 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL 360

Query: 361 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT 420
           HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
Sbjct: 361 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT 420

Query: 421 TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV 466
           TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
Sbjct: 421 TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV 466


>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
          Length = 475

 Score =  865 bits (2234), Expect = 0.0
 Identities = 426/434 (98%), Positives = 430/434 (99%)

Query: 1   MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60
           MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
Sbjct: 1   MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60

Query: 61  THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120
           THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
Sbjct: 61  THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120

Query: 121 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE 180
           SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
Sbjct: 121 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE 180

Query: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN 240
           EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
Sbjct: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN 240

Query: 241 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD 300
           APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
Sbjct: 241 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD 300

Query: 301 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL 360
           FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
Sbjct: 301 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL 360

Query: 361 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT 420
           HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
Sbjct: 361 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT 420

Query: 421 TARVRSKSFLQVCC 434
           TAR +S+S  ++ C
Sbjct: 421 TARTKSRSVTRLEC 434


>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
          Length = 455

 Score =  858 bits (2217), Expect = 0.0
 Identities = 423/423 (100%), Positives = 423/423 (100%)

Query: 1   MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60
           MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
Sbjct: 1   MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60

Query: 61  THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120
           THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
Sbjct: 61  THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120

Query: 121 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE 180
           SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
Sbjct: 121 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE 180

Query: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN 240
           EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
Sbjct: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN 240

Query: 241 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD 300
           APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
Sbjct: 241 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD 300

Query: 301 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL 360
           FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
Sbjct: 301 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL 360

Query: 361 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT 420
           HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
Sbjct: 361 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT 420

Query: 421 TAR 423
           TAR
Sbjct: 421 TAR 423


>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
          Length = 429

 Score =  858 bits (2217), Expect = 0.0
 Identities = 423/423 (100%), Positives = 423/423 (100%)

Query: 1   MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60
           MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
Sbjct: 1   MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60

Query: 61  THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120
           THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
Sbjct: 61  THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120

Query: 121 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE 180
           SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
Sbjct: 121 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE 180

Query: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN 240
           EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
Sbjct: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN 240

Query: 241 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD 300
           APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
Sbjct: 241 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD 300

Query: 301 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL 360
           FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
Sbjct: 301 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL 360

Query: 361 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT 420
           HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
Sbjct: 361 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT 420

Query: 421 TAR 423
           TAR
Sbjct: 421 TAR 423


>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
          Length = 520

 Score =  453 bits (1166), Expect = e-127
 Identities = 223/369 (60%), Positives = 283/369 (76%), Gaps = 15/369 (4%)

Query: 5   SGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYY 64
           +G    SSN T P   ++I++AI +G++LG  ILF ++GNILVILSVAC+RHL + T+Y+
Sbjct: 26  TGPNQTSSNSTLPQ--LDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYF 83

Query: 65  IVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR 124
           IVNLA+ADLLL+ TVLPFSA  EVLGYW  GR+FC+IWAAVDVLCCTASI+ LC ISIDR
Sbjct: 84  IVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDR 143

Query: 125 YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY 184
           YIGV Y L+YPT+VT+R+ ++ALL VW LS VISIGPL GW++PAP D+  C + EEP Y
Sbjct: 144 YIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFY 203

Query: 185 VLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAG 244
            LFS+LGSFY+PLA+ILVMYCRVY+VAKR ++ L++G+  + S+S+++TLRIH KN    
Sbjct: 204 ALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHE- 262

Query: 245 GSGMASAKTKTH-----FSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP 299
              ++S K K H      +V+L KFSREKKAAKTLGIVVG F+LCWLPFF+ +P+GS F 
Sbjct: 263 -DTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFS 321

Query: 300 DFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCL---CRKQSSKHAL 356
             KP + VFK+VFWLGY NSC+NPIIYPCSS+EFK+AF  +L  QC     R++  +  L
Sbjct: 322 TLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRL 381

Query: 357 G---YTLHP 362
           G   YT  P
Sbjct: 382 GGCAYTYRP 390


>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
          Length = 572

 Score =  433 bits (1113), Expect = e-121
 Identities = 203/333 (60%), Positives = 259/333 (77%), Gaps = 6/333 (1%)

Query: 24  SKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFS 83
           ++ + +GV L   IL  V GN+LVILSVAC+RHL +VT+Y+IVNLAVADLLL++TVLPFS
Sbjct: 94  AQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFS 153

Query: 84  AIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRG 143
           A  EVLG+WAFGR FC++WAAVDVLCCTASI+ LC IS+DRY+GV + L+YP I+T+R+ 
Sbjct: 154 ATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKA 213

Query: 144 LMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVM 203
              L  +W ++LV+S+GPL GW++P P DE  C I EE GY +FS++ SFYLP+A+I+VM
Sbjct: 214 AAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVM 273

Query: 204 YCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS---GMASAKTKT---HF 257
           YCRVYVVA+  +R L++G+K ++  + +V LRIH + A  G     GM SAK  T     
Sbjct: 274 YCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSL 333

Query: 258 SVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYL 317
           SVRLLKFSREKKAAKTL IVVG FVLCW PFF V+P+GS FP  KPSE VFK++FWLGY 
Sbjct: 334 SVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYF 393

Query: 318 NSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ 350
           NSC+NP+IYPCSS+EFK+AF  +LR QC  R++
Sbjct: 394 NSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR 426


>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
          Length = 479

 Score =  221 bits (563), Expect = 1e-57
 Identities = 132/376 (35%), Positives = 204/376 (54%), Gaps = 10/376 (2%)

Query: 27  ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86
           +++G IL  + L  + GN LV++SV   + L   ++Y IV+LA+ADL +   V+PF ++ 
Sbjct: 82  VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141

Query: 87  EVLG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145
           +++G  W FG  FCN++ A+DV+CCTASIM LC+ISIDRY+G++ PL YP     +    
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201

Query: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYC 205
            +L VW LS  I++ PLFGW Q    D+ +C I+++ GY ++S   +FY+P++++L MY 
Sbjct: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260

Query: 206 RVYVVAKRESRGLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF 264
           ++Y  A++ +   K  G    + DS      I +           S   K H    +  F
Sbjct: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIF 319

Query: 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPS---ETVFKIVFWLGYLNSCI 321
            RE+KAA TLGI+VG F +CWLPFFL+     F      S     V +   WLGY NS I
Sbjct: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLI 379

Query: 322 NPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGS 381
           NP IY   +++ +  ++++L  QC  R  + K +    +H   +  E   +    +   +
Sbjct: 380 NPFIYAFFNRDLRTTYRSLL--QCQYRNINRKLSAA-GMHEALKLAERPERPEFVLRACT 436

Query: 382 RETFYRISKTDGVCEW 397
           R    R  K   V  W
Sbjct: 437 RRVLLRPEKRPPVSVW 452


>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
          Length = 432

 Score =  220 bits (561), Expect = 2e-57
 Identities = 122/323 (37%), Positives = 188/323 (58%), Gaps = 7/323 (2%)

Query: 27  ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86
           +++G IL  + L  + GN LV++SV   + L   ++Y IV+LA+ADL +   V+PF ++ 
Sbjct: 82  VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141

Query: 87  EVLG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145
           +++G  W FG  FCN++ A+DV+CCTASIM LC+ISIDRY+G++ PL YP     +    
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201

Query: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYC 205
            +L VW LS  I++ PLFGW Q    D+ +C I+++ GY ++S   +FY+P++++L MY 
Sbjct: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260

Query: 206 RVYVVAKRESRGLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF 264
           ++Y  A++ +   K  G    + DS      I +           S   K H    +  F
Sbjct: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIF 319

Query: 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPS---ETVFKIVFWLGYLNSCI 321
            RE+KAA TLGI+VG F +CWLPFFL+     F      S     V +   WLGY NS I
Sbjct: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLI 379

Query: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344
           NP IY   +++ +  ++++L+ Q
Sbjct: 380 NPFIYAFFNRDLRTTYRSLLQCQ 402


>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
          Length = 445

 Score =  220 bits (561), Expect = 2e-57
 Identities = 122/323 (37%), Positives = 188/323 (58%), Gaps = 7/323 (2%)

Query: 27  ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86
           +++G IL  + L  + GN LV++SV   + L   ++Y IV+LA+ADL +   V+PF ++ 
Sbjct: 82  VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141

Query: 87  EVLG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145
           +++G  W FG  FCN++ A+DV+CCTASIM LC+ISIDRY+G++ PL YP     +    
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201

Query: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYC 205
            +L VW LS  I++ PLFGW Q    D+ +C I+++ GY ++S   +FY+P++++L MY 
Sbjct: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260

Query: 206 RVYVVAKRESRGLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF 264
           ++Y  A++ +   K  G    + DS      I +           S   K H    +  F
Sbjct: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIF 319

Query: 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPS---ETVFKIVFWLGYLNSCI 321
            RE+KAA TLGI+VG F +CWLPFFL+     F      S     V +   WLGY NS I
Sbjct: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLI 379

Query: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344
           NP IY   +++ +  ++++L+ Q
Sbjct: 380 NPFIYAFFNRDLRTTYRSLLQCQ 402


>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
           sapiens]
          Length = 390

 Score =  218 bits (554), Expect = 1e-56
 Identities = 131/366 (35%), Positives = 205/366 (56%), Gaps = 30/366 (8%)

Query: 7   NASDSSNCTQPPA----PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTH 62
           +++ S NC+         +++   +LL ++L  + L   L N  VI +V   R LH+  +
Sbjct: 26  SSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPAN 85

Query: 63  YYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
           Y I +LAV DLL++  V+P S ++ V G W  G+V C+ W + D+ CCTASI+ LC+I++
Sbjct: 86  YLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIAL 145

Query: 123 DRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDE-TICQIN-E 180
           DRY  ++  + Y    T +R  + +  VW  S+ IS+ P F WRQ   E+E + C +N +
Sbjct: 146 DRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFF-WRQAKAEEEVSECVVNTD 204

Query: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRE----------SRGLKSGLKTDKSDSE 230
              Y ++S +G+FY P  +++ +Y R+YV A+             R  ++ L TD   S 
Sbjct: 205 HILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGST 264

Query: 231 QVTLRIHRK--NAPA-GGSGMASAKTKTHFSVRLLK-----FSREKKAAKTLGIVVGCFV 282
                I+ +  + P+  GS +   + K   S  LL+      +RE+KA KTLGI++G F+
Sbjct: 265 SSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFI 324

Query: 283 LCWLPFF---LVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN 339
           +CWLPFF   LVMPI      F  +  +F    WLGYLNS INPIIY  S+++FK+AF  
Sbjct: 325 VCWLPFFIISLVMPICKDACWFHLA--IFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHK 382

Query: 340 VLRIQC 345
           ++R +C
Sbjct: 383 LIRFKC 388


>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
          Length = 477

 Score =  212 bits (540), Expect = 5e-55
 Identities = 128/362 (35%), Positives = 199/362 (54%), Gaps = 26/362 (7%)

Query: 15  TQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLL 74
           ++ P P++      +G+++  ++L  V GN+LVI+++A    L ++T+ +I++LA ADL+
Sbjct: 47  SESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLV 106

Query: 75  LTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRY 134
           +   V+PF A   V G W +G  FC +W +VDVLC TASI  LC+I++DRY+ ++ P RY
Sbjct: 107 MGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRY 166

Query: 135 PTIVTQRRGLMALLCVWALSLVISIGPLF--GWRQPAPE------DETICQINEEPGYVL 186
            +++T+ R    +  VWA+S ++S  P+    WR  + E      D   C       Y +
Sbjct: 167 QSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAI 226

Query: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKS-------GLKTDKSDSEQVTLR---- 235
            S++ SFY+PL I+  +Y RV+  A+++ + + S       G     S S          
Sbjct: 227 ASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPP 286

Query: 236 --IHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMP 293
               R  A A  + +A+ +       RL+   RE+KA KTLGI++G F LCWLPFFL   
Sbjct: 287 PGPPRPAAAAATAPLANGRAGKRRPSRLVAL-REQKALKTLGIIMGVFTLCWLPFFLANV 345

Query: 294 IGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSK 353
           + +F  +  P + +F    WLGY NS  NPIIY C S +F+KAFQ +L   C  R    +
Sbjct: 346 VKAFHRELVP-DRLFVFFNWLGYANSAFNPIIY-CRSPDFRKAFQGLL--CCARRAARRR 401

Query: 354 HA 355
           HA
Sbjct: 402 HA 403


>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
          Length = 413

 Score =  211 bits (537), Expect = 1e-54
 Identities = 125/352 (35%), Positives = 196/352 (55%), Gaps = 29/352 (8%)

Query: 29  LGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEV 88
           +G+++  ++L  V GN+LVI ++A    L +VT+Y+I +LA ADL++   V+PF A   +
Sbjct: 36  MGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHIL 95

Query: 89  LGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALL 148
           +  W FG  +C  W ++DVLC TASI  LC+I++DRY  ++ P +Y +++T+ +  + +L
Sbjct: 96  MKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIIL 155

Query: 149 CVWALSLVISIGPL-FGWRQPAPED-------ETICQINEEPGYVLFSALGSFYLPLAII 200
            VW +S + S  P+   W +   ++       ET C       Y + S++ SFY+PL I+
Sbjct: 156 MVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIM 215

Query: 201 LVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVR 260
           + +Y RV+  AKR+ +      K DKS+      R H +N     S +       H   R
Sbjct: 216 VFVYSRVFQEAKRQLQ------KIDKSEG-----RFHVQNL----SQVEQDGRTGHGLRR 260

Query: 261 LLKFS-REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNS 319
             KF  +E KA KTLGI++G F LCWLPFF+V  I     D    + V+ ++ W+GY+NS
Sbjct: 261 SSKFCLKEHKALKTLGIIMGTFTLCWLPFFIV-NIVHVIQDNLIRKEVYILLNWIGYVNS 319

Query: 320 CINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQH 371
             NP+IY C S +F+ AFQ +L   CL R     +  GY+ +  +    G H
Sbjct: 320 GFNPLIY-CRSPDFRIAFQELL---CLRRSSLKAYGNGYSSNGNTGEQSGYH 367


>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
           sapiens]
          Length = 366

 Score =  210 bits (534), Expect = 3e-54
 Identities = 129/370 (34%), Positives = 194/370 (52%), Gaps = 39/370 (10%)

Query: 7   NASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIV 66
           N+SD  N T       +   IL+ + L GL L     N LVI ++   R LH   +Y I 
Sbjct: 5   NSSDQ-NLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLIC 63

Query: 67  NLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYI 126
           +LAV D L+   V+PFS ++ V   W  G+V C+IW +VD+ CCT SI+ L  I++DRY 
Sbjct: 64  SLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYR 123

Query: 127 GVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVL 186
            ++  + Y    T +   + +  VW +S+ IS+ PLF   Q    D+     ++     +
Sbjct: 124 AITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTI 183

Query: 187 FSALGSFYLPLAIILVMYCRVY-------------VVAKRESRG---LKSGLKTDKSDSE 230
           +S  G+FY+PLA+IL++Y ++Y              +AK E  G   L+SG K+ KS S 
Sbjct: 184 YSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVST 243

Query: 231 QVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF---------------SREKKAAKTLG 275
              L           S  ++   K H +VR L+                +RE+KAA TLG
Sbjct: 244 SYVLE-------KSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLG 296

Query: 276 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
           +++G FV+CWLPFF+   + +     K SE +   + WLGYLNS INP+IY   +++FKK
Sbjct: 297 LILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKK 356

Query: 336 AFQNVLRIQC 345
           AFQ ++R +C
Sbjct: 357 AFQKLVRCRC 366


>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
           sapiens]
          Length = 377

 Score =  209 bits (532), Expect = 4e-54
 Identities = 125/356 (35%), Positives = 196/356 (55%), Gaps = 26/356 (7%)

Query: 7   NASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIV 66
           NA+++S    P     +   I L V+L  + L  VL N  V+ ++   R LH+  +Y I 
Sbjct: 21  NATETSEAWDPRTLQALK--ISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIG 78

Query: 67  NLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYI 126
           +LA  DLL++  V+P S  + +   W FG++ C+IW + D+ CCTASI+ LC+I++DRY 
Sbjct: 79  SLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYW 138

Query: 127 GVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQ-PAPEDETICQIN-EEPGY 184
            ++  L Y    T       +  VWA+S+ ISI PLF WRQ  A E+ + C +N  +  Y
Sbjct: 139 AITDALEYSKRRTAGHAATMIAIVWAISICISIPPLF-WRQAKAQEEMSDCLVNTSQISY 197

Query: 185 VLFSALGSFYLPLAIILVMYCRVYVVAKRE---------SRGLKSGLKTDKSDSEQVTLR 235
            ++S  G+FY+P  +++++Y R+Y  A+            R   + L T  + S   +L 
Sbjct: 198 TIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLN 257

Query: 236 --IHRKNAPAGGSGMASAKTKTHFSVRLLK-----FSREKKAAKTLGIVVGCFVLCWLPF 288
             +H  ++ + GS +     K   +   L+      +RE+KA K LGI++G F++CWLPF
Sbjct: 258 SSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPF 317

Query: 289 F---LVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
           F   LV+PI        P+  +F    WLGYLNS INPIIY   ++EF++AFQ ++
Sbjct: 318 FVVSLVLPICRDSCWIHPA--LFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371


>gi|4503383 dopamine receptor D1 [Homo sapiens]
          Length = 446

 Score =  207 bits (527), Expect = 2e-53
 Identities = 124/348 (35%), Positives = 190/348 (54%), Gaps = 37/348 (10%)

Query: 22  NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-VTHYYIVNLAVADLLLTSTVL 80
           + S  IL    L  LIL  +LGN LV  +V   RHL S VT++++++LAV+DLL+   V+
Sbjct: 19  DFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVM 78

Query: 81  PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140
           P+ A+ E+ G+W FG  FCNIW A D++C TASI+ LC+IS+DRY  +S P RY   +T 
Sbjct: 79  PWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTP 137

Query: 141 RRGLMALLCVWALSLVISIGPL-FGWRQPAPED----------ETI--CQINEEPGYVLF 187
           +   + +   W LS++IS  P+   W +  P            ETI  C  +    Y + 
Sbjct: 138 KAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAIS 197

Query: 188 SALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN---APAG 244
           S++ SFY+P+AI++V Y R+Y +A+++ R + +  +            +H KN       
Sbjct: 198 SSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERA----------AVHAKNCQTTTGN 247

Query: 245 GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF-----FP 299
           G  +  ++ ++ F    + F RE K  KTL +++G FV CWLPFF++  I  F       
Sbjct: 248 GKPVECSQPESSFK---MSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQ 304

Query: 300 DFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLC 347
            F      F +  W G+ NS +NPIIY  ++ +F+KAF  +L    LC
Sbjct: 305 PFCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGCYRLC 351


>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
          Length = 408

 Score =  202 bits (513), Expect = 7e-52
 Identities = 120/335 (35%), Positives = 176/335 (52%), Gaps = 13/335 (3%)

Query: 25  KAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSA 84
           +A L G +L   +L  V GN+LVI+++A    L ++T+ ++ +LA ADL++   V+P +A
Sbjct: 36  EAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAA 95

Query: 85  IFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGL 144
              + G+W  G   C +W +VDVLC TASI  LC +++DRY+ V+ PLRY  +VT+R   
Sbjct: 96  TLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCAR 155

Query: 145 MALLCVWALSLVISIGPLFG--WRQPAPEDETICQIN-------EEPGYVLFSALGSFYL 195
            A++ VW +S  +S  P+    WR  A  +   C  N           YVL S+  SFYL
Sbjct: 156 TAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYL 215

Query: 196 PLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKT 255
           PL ++L +Y RV+VVA R+ R L+  L     +            AP G           
Sbjct: 216 PLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPAC 275

Query: 256 HFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLG 315
                 L   RE +A  TLG+++G F LCWLPFFL   + +           F  + WLG
Sbjct: 276 GRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLG 335

Query: 316 YLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ 350
           Y NS  NP+IY C S +F+ AF+   R+ C C ++
Sbjct: 336 YANSAFNPLIY-CRSPDFRSAFR---RLLCRCGRR 366


>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
           sapiens]
          Length = 365

 Score =  201 bits (512), Expect = 9e-52
 Identities = 123/370 (33%), Positives = 194/370 (52%), Gaps = 38/370 (10%)

Query: 12  SNCTQPPA----PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVN 67
           +NCT   +    P  I++ +L+ + L  +     L N+ VI+++   + LH   +Y I +
Sbjct: 4   TNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICS 63

Query: 68  LAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIG 127
           LAV DLL+   V+P S I+ V+  W  G   C +W +VD+ CCT SI+ LC+I++DRY  
Sbjct: 64  LAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWA 123

Query: 128 VSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWR-----QPAPEDETICQINEEP 182
           ++  + Y    T +R  + +L VW +S+ IS+ PLF WR      P P   TI   ++  
Sbjct: 124 ITNAIEYARKRTAKRAALMILTVWTISIFISMPPLF-WRSHRRLSPPPSQCTI--QHDHV 180

Query: 183 GYVLFSALGSFYLPLAIILVMYCRVYVVAKR--ESRGLKSGLKTDKSDSEQVTLRIHRKN 240
            Y ++S LG+FY+PL +IL++Y R+Y  AK   + RG    L    +DS+          
Sbjct: 181 IYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQ 240

Query: 241 APAGGSGMASAKT----KTHFSVRLLKF---------------SREKKAAKTLGIVVGCF 281
                    S  T    K H S+R+  F               +RE+KAA+ LG+++G F
Sbjct: 241 TFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAF 300

Query: 282 VLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
           +L WLPFF+   I      +  S  V   + WLGY+NS INP++Y   +++FK AF+ ++
Sbjct: 301 ILSWLPFFIKELIVG-LSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLI 359

Query: 342 RIQCLCRKQS 351
           R    CR+ +
Sbjct: 360 R----CREHT 365


>gi|4503391 dopamine receptor D5 [Homo sapiens]
          Length = 477

 Score =  201 bits (511), Expect = 1e-51
 Identities = 131/381 (34%), Positives = 197/381 (51%), Gaps = 60/381 (15%)

Query: 6   GNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-VTHYY 64
           GNA   S    P  P  +  A LL +    LI++ +LGN+LV  ++   RHL + +T+ +
Sbjct: 24  GNAVGGSAGAPPLGPSQVVTACLLTL----LIIWTLLGNVLVCAAIVRSRHLRANMTNVF 79

Query: 65  IVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR 124
           IV+LAV+DL +   V+P+ A+ EV GYW FG  FC++W A D++C TASI+ LC+IS+DR
Sbjct: 80  IVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDR 138

Query: 125 YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ---------------- 167
           Y  +S P RY   +TQR  L+ +   W LS++IS  P+   W +                
Sbjct: 139 YWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLA 198

Query: 168 ---PAPEDETICQINEE-------PGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRG 217
              P  ED     +N E         Y + S+L SFY+P+AI++V Y R+Y +A+ + R 
Sbjct: 199 NWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRR 258

Query: 218 LKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIV 277
           + S                  + A    S  +SA      S+R     +E K  KTL ++
Sbjct: 259 ISS----------------LERAAEHAQSCRSSAACAPDTSLR-ASIKKETKVLKTLSVI 301

Query: 278 VGCFVLCWLPFFL---VMPIGSFFPDFKP------SETVFKIVFWLGYLNSCINPIIYPC 328
           +G FV CWLPFF+   ++P  S  P+  P      SET F +  W G+ NS +NP+IY  
Sbjct: 302 MGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAF 361

Query: 329 SSQEFKKAFQNVLRIQCLCRK 349
           ++ +F+K F  +L     C +
Sbjct: 362 NA-DFQKVFAQLLGCSHFCSR 381


>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
          Length = 397

 Score =  201 bits (510), Expect = 2e-51
 Identities = 122/359 (33%), Positives = 185/359 (51%), Gaps = 48/359 (13%)

Query: 4   LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
           ++ N + SS C    A       I + V+L  LIL  V GN++V L+V  +R L ++T+ 
Sbjct: 1   MAPNGTASSFCLDSTAC-----KITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNC 55

Query: 64  YIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISID 123
           +IV+LA+ DLLL   VLPFSAI+++   W+FG+VFCNI+ ++DV+ CTASI+ L +IS+D
Sbjct: 56  FIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLD 115

Query: 124 RYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWR-----QPAPEDETICQ 177
           RY  V  PLRYP +VT  R  ++L+ +W +S+ +S   +  GW             + C+
Sbjct: 116 RYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCK 175

Query: 178 INEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIH 237
           +     Y L   L +FYLPL I+ + Y R++ VA+ +                       
Sbjct: 176 VQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQ----------------------- 212

Query: 238 RKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF 297
                        AK   H S       RE KA  TL  V+G F++CW P+F        
Sbjct: 213 -------------AKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGL 259

Query: 298 FPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHAL 356
             D   +E +  IV WLGY NS +NPI+Y   +++F+  +Q +   + L  + S K +L
Sbjct: 260 RGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCR-LANRNSHKTSL 317


>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
          Length = 359

 Score =  201 bits (510), Expect = 2e-51
 Identities = 122/359 (33%), Positives = 185/359 (51%), Gaps = 48/359 (13%)

Query: 4   LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
           ++ N + SS C    A       I + V+L  LIL  V GN++V L+V  +R L ++T+ 
Sbjct: 1   MAPNGTASSFCLDSTAC-----KITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNC 55

Query: 64  YIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISID 123
           +IV+LA+ DLLL   VLPFSAI+++   W+FG+VFCNI+ ++DV+ CTASI+ L +IS+D
Sbjct: 56  FIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLD 115

Query: 124 RYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWR-----QPAPEDETICQ 177
           RY  V  PLRYP +VT  R  ++L+ +W +S+ +S   +  GW             + C+
Sbjct: 116 RYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCK 175

Query: 178 INEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIH 237
           +     Y L   L +FYLPL I+ + Y R++ VA+ +                       
Sbjct: 176 VQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQ----------------------- 212

Query: 238 RKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF 297
                        AK   H S       RE KA  TL  V+G F++CW P+F        
Sbjct: 213 -------------AKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGL 259

Query: 298 FPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHAL 356
             D   +E +  IV WLGY NS +NPI+Y   +++F+  +Q +   + L  + S K +L
Sbjct: 260 RGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCR-LANRNSHKTSL 317


>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
          Length = 367

 Score =  198 bits (504), Expect = 8e-51
 Identities = 120/333 (36%), Positives = 179/333 (53%), Gaps = 33/333 (9%)

Query: 36  LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAF 94
           LIL  V GN LV ++V   R L + T+Y +V+LAVADLL+ + V+P+    EV G  W F
Sbjct: 39  LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98

Query: 95  GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ---RRGLMALLCVW 151
            R+ C+++  +DV+ CTASI+ LC ISIDRY  V  P+ Y     Q   RR  + +  VW
Sbjct: 99  SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158

Query: 152 ALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211
            L+  +S   LFG+      D T+C I+  P +V++S++ SFYLP  + +++Y R+YVV 
Sbjct: 159 VLAFAVSCPLLFGFNTTG--DPTVCSISN-PDFVIYSSVVSFYLPFGVTVLVYARIYVVL 215

Query: 212 KRESR------------GLKSGLKTDKSDSEQVTLRIHR-----KNAPAGGSGMASA--- 251
           K+  R             ++ G        +   L + R     ++   GG G       
Sbjct: 216 KQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGE 275

Query: 252 ---KTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVF 308
              + KT  S+  L   REKKA + + IV+G F++CWLPFFL   + +       S  ++
Sbjct: 276 LKREEKTRNSLMPL---REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELY 332

Query: 309 KIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
               WLGY+NS +NP+IY   + EF+KAF  +L
Sbjct: 333 SATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 365


>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
          Length = 357

 Score =  194 bits (494), Expect = 1e-49
 Identities = 113/339 (33%), Positives = 180/339 (53%), Gaps = 8/339 (2%)

Query: 4   LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
           L  N S   +  +P +P+     +L+  +LG L+      N+LV+ ++   R  H V H 
Sbjct: 18  LETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHN 77

Query: 64  YIVNLAVADLLLTSTVLPFSAIFEVLGY-WAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
            + ++AV+D+L+ + V+P S + E+ G  W  GR  C +W A DVLCCTASI  +  I++
Sbjct: 78  LVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137

Query: 123 DRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGP-LFGWRQPAPEDETICQINEE 181
           DRY  ++  + Y     +    + +   WALS VIS+ P LFGW +   E    CQ++ E
Sbjct: 138 DRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSRE 197

Query: 182 PGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNA 241
           P Y +FS +G+FYLPL ++L +Y ++Y  AK      K+   +  S++ +V         
Sbjct: 198 PSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVK---DSAKQ 254

Query: 242 PAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDF 301
           P     +  A           +  +E++AA  +GI++G FVLCW+PFFL   I       
Sbjct: 255 PQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCD 314

Query: 302 KPSETVFKIVF-WLGYLNSCINPIIYPCSSQEFKKAFQN 339
            P+  ++K +F WLGY NS  NP+IY   ++ +  AF+N
Sbjct: 315 IPA--IWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKN 351


>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
          Length = 400

 Score =  188 bits (478), Expect = 8e-48
 Identities = 121/363 (33%), Positives = 181/363 (49%), Gaps = 60/363 (16%)

Query: 36  LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAF 94
           LIL  V GN LV ++V   R L + T+Y +V+LAVADLL+ + V+P+    EV G  W F
Sbjct: 39  LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98

Query: 95  GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ---RRGLMALLCVW 151
            R+ C+++  +DV+ CTASI+ LC ISIDRY  V  P+ Y     Q   RR  + +  VW
Sbjct: 99  SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158

Query: 152 ALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211
            L+  +S   LFG+      D T+C I+  P +V++S++ SFYLP  + +++Y R+YVV 
Sbjct: 159 VLAFAVSCPLLFGFNTTG--DPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVVL 215

Query: 212 KRESR------------GLKSGLKTDKSDSEQVTLRIHR-----KNAPAGGSGM------ 248
           K+  R             ++ G        +   L + R     ++   GG G       
Sbjct: 216 KQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGE 275

Query: 249 --ASAKTKT--------HFSVRLLKFS--------------------REKKAAKTLGIVV 278
                KT+           S+ + K S                    REKKA + + IV+
Sbjct: 276 LKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVL 335

Query: 279 GCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQ 338
           G F++CWLPFFL   + +       S  ++    WLGY+NS +NP+IY   + EF+KAF 
Sbjct: 336 GAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFL 395

Query: 339 NVL 341
            +L
Sbjct: 396 KIL 398


>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
          Length = 414

 Score =  178 bits (451), Expect = 1e-44
 Identities = 119/374 (31%), Positives = 185/374 (49%), Gaps = 73/374 (19%)

Query: 36  LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95
           LI   V GN+LV ++V+  + L + T+Y IV+LAVADLL+ + V+P+    EV+G W F 
Sbjct: 44  LIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFS 103

Query: 96  RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALL-CVWALS 154
           R+ C+I+  +DV+ CTASI+ LC ISIDRY  V+ P+ Y T  + +R +  ++  VW LS
Sbjct: 104 RIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLS 163

Query: 155 LVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVV---- 210
             IS   LFG       D+  C I   P +V++S++ SFY+P  + L++Y ++Y+V    
Sbjct: 164 FTISCPLLFGLNN---ADQNEC-IIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRR 219

Query: 211 -----AKRESRGLKSGLKTDKSDS------------------------------EQVTL- 234
                 KR SR  ++ L+    ++                               Q+TL 
Sbjct: 220 RKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLP 279

Query: 235 -----RIH-RKNAPA----GGSGMASAKTKTHFSVRLLKFSREKKAAKT----------- 273
                 +H   ++PA     G      K    F ++ +   + + + KT           
Sbjct: 280 DPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKE 339

Query: 274 ------LGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYP 327
                 L IV+G F++CWLPFF +  I +   D      ++    WLGY+NS +NPIIY 
Sbjct: 340 KKATQMLAIVLGVFIICWLPFF-ITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYT 398

Query: 328 CSSQEFKKAFQNVL 341
             + EF+KAF  +L
Sbjct: 399 TFNIEFRKAFLKIL 412


>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
          Length = 387

 Score =  177 bits (448), Expect = 2e-44
 Identities = 122/390 (31%), Positives = 188/390 (48%), Gaps = 61/390 (15%)

Query: 22  NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV-THYYIVNLAVADLLLTSTVL 80
           ++ K +LL   L  +IL  +LGN+LV+++V   R L  + T+Y+IV+LA ADLL++  V+
Sbjct: 16  SVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVM 74

Query: 81  PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGV-SYPLRYPTIVT 139
           PF AI  V   W +G VFC +  ++DVL  TASI  LC IS+DRY  +   PL Y   +T
Sbjct: 75  PFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134

Query: 140 QRRGLMALLCVWALSLVISIGPLF-GWRQPAPED------------ETICQINEEPGYVL 186
             R  + L   W +   IS  P+  GW      D             T C       Y +
Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194

Query: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS 246
             ++ +FY+P  ++++ Y R+YV AK  +  ++                + R  A +   
Sbjct: 195 TCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ---------------MLQRAGASSESR 239

Query: 247 GMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSET 306
             ++ +  TH      +   E KAAKTL I++GCF LCW PFF+   +  F  D+     
Sbjct: 240 PQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI-DYTVPGQ 292

Query: 307 VFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL---------------RIQCLCRK-Q 350
           V+    WLGY+NS +NP +Y   ++ F++AF  +L                + C      
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTIN 352

Query: 351 SSKHALGYT-LHPPSQAVEGQHKDMVRIPV 379
            S H L YT LH       G H+++ ++P+
Sbjct: 353 GSTHVLRYTVLH------RGHHQELEKLPI 376


>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
          Length = 359

 Score =  174 bits (442), Expect = 1e-43
 Identities = 111/335 (33%), Positives = 170/335 (50%), Gaps = 38/335 (11%)

Query: 22  NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV-THYYIVNLAVADLLLTSTVL 80
           ++ K +LL   L  +IL  +LGN+LV+++V   R L  + T+Y+IV+LA ADLL++  V+
Sbjct: 16  SVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVM 74

Query: 81  PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGV-SYPLRYPTIVT 139
           PF AI  V   W +G VFC +  ++DVL  TASI  LC IS+DRY  +   PL Y   +T
Sbjct: 75  PFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134

Query: 140 QRRGLMALLCVWALSLVISIGPLF-GWRQPAPED------------ETICQINEEPGYVL 186
             R  + L   W +   IS  P+  GW      D             T C       Y +
Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194

Query: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS 246
             ++ +FY+P  ++++ Y R+YV AK  +  ++                + R  A +   
Sbjct: 195 TCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ---------------MLQRAGASSESR 239

Query: 247 GMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSET 306
             ++ +  TH      +   E KAAKTL I++GCF LCW PFF+   +  F  D+     
Sbjct: 240 PQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI-DYTVPGQ 292

Query: 307 VFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
           V+    WLGY+NS +NP +Y   ++ F++AF  +L
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL 327


>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
          Length = 428

 Score =  174 bits (442), Expect = 1e-43
 Identities = 111/335 (33%), Positives = 170/335 (50%), Gaps = 38/335 (11%)

Query: 22  NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV-THYYIVNLAVADLLLTSTVL 80
           ++ K +LL   L  +IL  +LGN+LV+++V   R L  + T+Y+IV+LA ADLL++  V+
Sbjct: 16  SVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVM 74

Query: 81  PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGV-SYPLRYPTIVT 139
           PF AI  V   W +G VFC +  ++DVL  TASI  LC IS+DRY  +   PL Y   +T
Sbjct: 75  PFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134

Query: 140 QRRGLMALLCVWALSLVISIGPLF-GWRQPAPED------------ETICQINEEPGYVL 186
             R  + L   W +   IS  P+  GW      D             T C       Y +
Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194

Query: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS 246
             ++ +FY+P  ++++ Y R+YV AK  +  ++                + R  A +   
Sbjct: 195 TCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ---------------MLQRAGASSESR 239

Query: 247 GMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSET 306
             ++ +  TH      +   E KAAKTL I++GCF LCW PFF+   +  F  D+     
Sbjct: 240 PQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI-DYTVPGQ 292

Query: 307 VFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
           V+    WLGY+NS +NP +Y   ++ F++AF  +L
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL 327


>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
          Length = 360

 Score =  174 bits (442), Expect = 1e-43
 Identities = 111/335 (33%), Positives = 170/335 (50%), Gaps = 38/335 (11%)

Query: 22  NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV-THYYIVNLAVADLLLTSTVL 80
           ++ K +LL   L  +IL  +LGN+LV+++V   R L  + T+Y+IV+LA ADLL++  V+
Sbjct: 16  SVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVM 74

Query: 81  PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGV-SYPLRYPTIVT 139
           PF AI  V   W +G VFC +  ++DVL  TASI  LC IS+DRY  +   PL Y   +T
Sbjct: 75  PFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134

Query: 140 QRRGLMALLCVWALSLVISIGPLF-GWRQPAPED------------ETICQINEEPGYVL 186
             R  + L   W +   IS  P+  GW      D             T C       Y +
Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194

Query: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS 246
             ++ +FY+P  ++++ Y R+YV AK  +  ++                + R  A +   
Sbjct: 195 TCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ---------------MLQRAGASSESR 239

Query: 247 GMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSET 306
             ++ +  TH      +   E KAAKTL I++GCF LCW PFF+   +  F  D+     
Sbjct: 240 PQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI-DYTVPGQ 292

Query: 307 VFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
           V+    WLGY+NS +NP +Y   ++ F++AF  +L
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL 327


>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
          Length = 378

 Score =  174 bits (442), Expect = 1e-43
 Identities = 111/335 (33%), Positives = 170/335 (50%), Gaps = 38/335 (11%)

Query: 22  NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV-THYYIVNLAVADLLLTSTVL 80
           ++ K +LL   L  +IL  +LGN+LV+++V   R L  + T+Y+IV+LA ADLL++  V+
Sbjct: 16  SVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVM 74

Query: 81  PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGV-SYPLRYPTIVT 139
           PF AI  V   W +G VFC +  ++DVL  TASI  LC IS+DRY  +   PL Y   +T
Sbjct: 75  PFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134

Query: 140 QRRGLMALLCVWALSLVISIGPLF-GWRQPAPED------------ETICQINEEPGYVL 186
             R  + L   W +   IS  P+  GW      D             T C       Y +
Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194

Query: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS 246
             ++ +FY+P  ++++ Y R+YV AK  +  ++                + R  A +   
Sbjct: 195 TCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ---------------MLQRAGASSESR 239

Query: 247 GMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSET 306
             ++ +  TH      +   E KAAKTL I++GCF LCW PFF+   +  F  D+     
Sbjct: 240 PQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI-DYTVPGQ 292

Query: 307 VFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
           V+    WLGY+NS +NP +Y   ++ F++AF  +L
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL 327


>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
          Length = 388

 Score =  174 bits (442), Expect = 1e-43
 Identities = 111/335 (33%), Positives = 170/335 (50%), Gaps = 38/335 (11%)

Query: 22  NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV-THYYIVNLAVADLLLTSTVL 80
           ++ K +LL   L  +IL  +LGN+LV+++V   R L  + T+Y+IV+LA ADLL++  V+
Sbjct: 16  SVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVM 74

Query: 81  PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGV-SYPLRYPTIVT 139
           PF AI  V   W +G VFC +  ++DVL  TASI  LC IS+DRY  +   PL Y   +T
Sbjct: 75  PFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134

Query: 140 QRRGLMALLCVWALSLVISIGPLF-GWRQPAPED------------ETICQINEEPGYVL 186
             R  + L   W +   IS  P+  GW      D             T C       Y +
Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194

Query: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS 246
             ++ +FY+P  ++++ Y R+YV AK  +  ++                + R  A +   
Sbjct: 195 TCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ---------------MLQRAGASSESR 239

Query: 247 GMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSET 306
             ++ +  TH      +   E KAAKTL I++GCF LCW PFF+   +  F  D+     
Sbjct: 240 PQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI-DYTVPGQ 292

Query: 307 VFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
           V+    WLGY+NS +NP +Y   ++ F++AF  +L
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL 327


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.139    0.436 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,647,776
Number of Sequences: 37866
Number of extensions: 746648
Number of successful extensions: 4359
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 637
Number of HSP's successfully gapped in prelim test: 132
Number of HSP's that attempted gapping in prelim test: 2239
Number of HSP's gapped (non-prelim): 1358
length of query: 466
length of database: 18,247,518
effective HSP length: 106
effective length of query: 360
effective length of database: 14,233,722
effective search space: 5124139920
effective search space used: 5124139920
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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