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Search of human proteins with 111118992
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo
sapiens]
(466 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 946 0.0
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 865 0.0
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 858 0.0
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 858 0.0
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 453 e-127
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 433 e-121
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 221 1e-57
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 220 2e-57
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 220 2e-57
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 218 1e-56
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 212 5e-55
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 211 1e-54
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 210 3e-54
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 209 4e-54
gi|4503383 dopamine receptor D1 [Homo sapiens] 207 2e-53
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 202 7e-52
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 201 9e-52
gi|4503391 dopamine receptor D5 [Homo sapiens] 201 1e-51
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 201 2e-51
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 201 2e-51
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 198 8e-51
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 194 1e-49
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 188 8e-48
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 178 1e-44
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 177 2e-44
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 174 1e-43
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 174 1e-43
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 174 1e-43
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 174 1e-43
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 174 1e-43
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 946 bits (2445), Expect = 0.0
Identities = 466/466 (100%), Positives = 466/466 (100%)
Query: 1 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
Sbjct: 1 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60
Query: 61 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
Sbjct: 61 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120
Query: 121 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE 180
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
Sbjct: 121 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE 180
Query: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN 240
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
Sbjct: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN 240
Query: 241 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD 300
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
Sbjct: 241 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD 300
Query: 301 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL 360
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
Sbjct: 301 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL 360
Query: 361 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT 420
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
Sbjct: 361 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT 420
Query: 421 TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV 466
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
Sbjct: 421 TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV 466
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 865 bits (2234), Expect = 0.0
Identities = 426/434 (98%), Positives = 430/434 (99%)
Query: 1 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
Sbjct: 1 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60
Query: 61 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
Sbjct: 61 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120
Query: 121 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE 180
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
Sbjct: 121 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE 180
Query: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN 240
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
Sbjct: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN 240
Query: 241 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD 300
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
Sbjct: 241 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD 300
Query: 301 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL 360
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
Sbjct: 301 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL 360
Query: 361 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT 420
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
Sbjct: 361 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT 420
Query: 421 TARVRSKSFLQVCC 434
TAR +S+S ++ C
Sbjct: 421 TARTKSRSVTRLEC 434
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 858 bits (2217), Expect = 0.0
Identities = 423/423 (100%), Positives = 423/423 (100%)
Query: 1 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
Sbjct: 1 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60
Query: 61 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
Sbjct: 61 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120
Query: 121 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE 180
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
Sbjct: 121 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE 180
Query: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN 240
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
Sbjct: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN 240
Query: 241 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD 300
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
Sbjct: 241 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD 300
Query: 301 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL 360
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
Sbjct: 301 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL 360
Query: 361 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT 420
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
Sbjct: 361 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT 420
Query: 421 TAR 423
TAR
Sbjct: 421 TAR 423
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 858 bits (2217), Expect = 0.0
Identities = 423/423 (100%), Positives = 423/423 (100%)
Query: 1 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
Sbjct: 1 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60
Query: 61 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
Sbjct: 61 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII 120
Query: 121 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE 180
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
Sbjct: 121 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE 180
Query: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN 240
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
Sbjct: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN 240
Query: 241 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD 300
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
Sbjct: 241 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD 300
Query: 301 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL 360
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
Sbjct: 301 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL 360
Query: 361 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT 420
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
Sbjct: 361 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT 420
Query: 421 TAR 423
TAR
Sbjct: 421 TAR 423
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 453 bits (1166), Expect = e-127
Identities = 223/369 (60%), Positives = 283/369 (76%), Gaps = 15/369 (4%)
Query: 5 SGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYY 64
+G SSN T P ++I++AI +G++LG ILF ++GNILVILSVAC+RHL + T+Y+
Sbjct: 26 TGPNQTSSNSTLPQ--LDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYF 83
Query: 65 IVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR 124
IVNLA+ADLLL+ TVLPFSA EVLGYW GR+FC+IWAAVDVLCCTASI+ LC ISIDR
Sbjct: 84 IVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDR 143
Query: 125 YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGY 184
YIGV Y L+YPT+VT+R+ ++ALL VW LS VISIGPL GW++PAP D+ C + EEP Y
Sbjct: 144 YIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFY 203
Query: 185 VLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAG 244
LFS+LGSFY+PLA+ILVMYCRVY+VAKR ++ L++G+ + S+S+++TLRIH KN
Sbjct: 204 ALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHE- 262
Query: 245 GSGMASAKTKTH-----FSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP 299
++S K K H +V+L KFSREKKAAKTLGIVVG F+LCWLPFF+ +P+GS F
Sbjct: 263 -DTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFS 321
Query: 300 DFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCL---CRKQSSKHAL 356
KP + VFK+VFWLGY NSC+NPIIYPCSS+EFK+AF +L QC R++ + L
Sbjct: 322 TLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRL 381
Query: 357 G---YTLHP 362
G YT P
Sbjct: 382 GGCAYTYRP 390
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 433 bits (1113), Expect = e-121
Identities = 203/333 (60%), Positives = 259/333 (77%), Gaps = 6/333 (1%)
Query: 24 SKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFS 83
++ + +GV L IL V GN+LVILSVAC+RHL +VT+Y+IVNLAVADLLL++TVLPFS
Sbjct: 94 AQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFS 153
Query: 84 AIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRG 143
A EVLG+WAFGR FC++WAAVDVLCCTASI+ LC IS+DRY+GV + L+YP I+T+R+
Sbjct: 154 ATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKA 213
Query: 144 LMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVM 203
L +W ++LV+S+GPL GW++P P DE C I EE GY +FS++ SFYLP+A+I+VM
Sbjct: 214 AAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVM 273
Query: 204 YCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS---GMASAKTKT---HF 257
YCRVYVVA+ +R L++G+K ++ + +V LRIH + A G GM SAK T
Sbjct: 274 YCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSL 333
Query: 258 SVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYL 317
SVRLLKFSREKKAAKTL IVVG FVLCW PFF V+P+GS FP KPSE VFK++FWLGY
Sbjct: 334 SVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYF 393
Query: 318 NSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ 350
NSC+NP+IYPCSS+EFK+AF +LR QC R++
Sbjct: 394 NSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR 426
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 221 bits (563), Expect = 1e-57
Identities = 132/376 (35%), Positives = 204/376 (54%), Gaps = 10/376 (2%)
Query: 27 ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86
+++G IL + L + GN LV++SV + L ++Y IV+LA+ADL + V+PF ++
Sbjct: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141
Query: 87 EVLG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145
+++G W FG FCN++ A+DV+CCTASIM LC+ISIDRY+G++ PL YP +
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201
Query: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYC 205
+L VW LS I++ PLFGW Q D+ +C I+++ GY ++S +FY+P++++L MY
Sbjct: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260
Query: 206 RVYVVAKRESRGLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF 264
++Y A++ + K G + DS I + S K H + F
Sbjct: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIF 319
Query: 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPS---ETVFKIVFWLGYLNSCI 321
RE+KAA TLGI+VG F +CWLPFFL+ F S V + WLGY NS I
Sbjct: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLI 379
Query: 322 NPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGS 381
NP IY +++ + ++++L QC R + K + +H + E + + +
Sbjct: 380 NPFIYAFFNRDLRTTYRSLL--QCQYRNINRKLSAA-GMHEALKLAERPERPEFVLRACT 436
Query: 382 RETFYRISKTDGVCEW 397
R R K V W
Sbjct: 437 RRVLLRPEKRPPVSVW 452
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 220 bits (561), Expect = 2e-57
Identities = 122/323 (37%), Positives = 188/323 (58%), Gaps = 7/323 (2%)
Query: 27 ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86
+++G IL + L + GN LV++SV + L ++Y IV+LA+ADL + V+PF ++
Sbjct: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141
Query: 87 EVLG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145
+++G W FG FCN++ A+DV+CCTASIM LC+ISIDRY+G++ PL YP +
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201
Query: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYC 205
+L VW LS I++ PLFGW Q D+ +C I+++ GY ++S +FY+P++++L MY
Sbjct: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260
Query: 206 RVYVVAKRESRGLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF 264
++Y A++ + K G + DS I + S K H + F
Sbjct: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIF 319
Query: 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPS---ETVFKIVFWLGYLNSCI 321
RE+KAA TLGI+VG F +CWLPFFL+ F S V + WLGY NS I
Sbjct: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLI 379
Query: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344
NP IY +++ + ++++L+ Q
Sbjct: 380 NPFIYAFFNRDLRTTYRSLLQCQ 402
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 220 bits (561), Expect = 2e-57
Identities = 122/323 (37%), Positives = 188/323 (58%), Gaps = 7/323 (2%)
Query: 27 ILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIF 86
+++G IL + L + GN LV++SV + L ++Y IV+LA+ADL + V+PF ++
Sbjct: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141
Query: 87 EVLG-YWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145
+++G W FG FCN++ A+DV+CCTASIM LC+ISIDRY+G++ PL YP +
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201
Query: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYC 205
+L VW LS I++ PLFGW Q D+ +C I+++ GY ++S +FY+P++++L MY
Sbjct: 202 MILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYY 260
Query: 206 RVYVVAKRESRGLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF 264
++Y A++ + K G + DS I + S K H + F
Sbjct: 261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIF 319
Query: 265 SREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPS---ETVFKIVFWLGYLNSCI 321
RE+KAA TLGI+VG F +CWLPFFL+ F S V + WLGY NS I
Sbjct: 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLI 379
Query: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344
NP IY +++ + ++++L+ Q
Sbjct: 380 NPFIYAFFNRDLRTTYRSLLQCQ 402
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 218 bits (554), Expect = 1e-56
Identities = 131/366 (35%), Positives = 205/366 (56%), Gaps = 30/366 (8%)
Query: 7 NASDSSNCTQPPA----PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTH 62
+++ S NC+ +++ +LL ++L + L L N VI +V R LH+ +
Sbjct: 26 SSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPAN 85
Query: 63 YYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
Y I +LAV DLL++ V+P S ++ V G W G+V C+ W + D+ CCTASI+ LC+I++
Sbjct: 86 YLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIAL 145
Query: 123 DRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDE-TICQIN-E 180
DRY ++ + Y T +R + + VW S+ IS+ P F WRQ E+E + C +N +
Sbjct: 146 DRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFF-WRQAKAEEEVSECVVNTD 204
Query: 181 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRE----------SRGLKSGLKTDKSDSE 230
Y ++S +G+FY P +++ +Y R+YV A+ R ++ L TD S
Sbjct: 205 HILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGST 264
Query: 231 QVTLRIHRK--NAPA-GGSGMASAKTKTHFSVRLLK-----FSREKKAAKTLGIVVGCFV 282
I+ + + P+ GS + + K S LL+ +RE+KA KTLGI++G F+
Sbjct: 265 SSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFI 324
Query: 283 LCWLPFF---LVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN 339
+CWLPFF LVMPI F + +F WLGYLNS INPIIY S+++FK+AF
Sbjct: 325 VCWLPFFIISLVMPICKDACWFHLA--IFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHK 382
Query: 340 VLRIQC 345
++R +C
Sbjct: 383 LIRFKC 388
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 212 bits (540), Expect = 5e-55
Identities = 128/362 (35%), Positives = 199/362 (54%), Gaps = 26/362 (7%)
Query: 15 TQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLL 74
++ P P++ +G+++ ++L V GN+LVI+++A L ++T+ +I++LA ADL+
Sbjct: 47 SESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLV 106
Query: 75 LTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRY 134
+ V+PF A V G W +G FC +W +VDVLC TASI LC+I++DRY+ ++ P RY
Sbjct: 107 MGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRY 166
Query: 135 PTIVTQRRGLMALLCVWALSLVISIGPLF--GWRQPAPE------DETICQINEEPGYVL 186
+++T+ R + VWA+S ++S P+ WR + E D C Y +
Sbjct: 167 QSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAI 226
Query: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKS-------GLKTDKSDSEQVTLR---- 235
S++ SFY+PL I+ +Y RV+ A+++ + + S G S S
Sbjct: 227 ASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPP 286
Query: 236 --IHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMP 293
R A A + +A+ + RL+ RE+KA KTLGI++G F LCWLPFFL
Sbjct: 287 PGPPRPAAAAATAPLANGRAGKRRPSRLVAL-REQKALKTLGIIMGVFTLCWLPFFLANV 345
Query: 294 IGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSK 353
+ +F + P + +F WLGY NS NPIIY C S +F+KAFQ +L C R +
Sbjct: 346 VKAFHRELVP-DRLFVFFNWLGYANSAFNPIIY-CRSPDFRKAFQGLL--CCARRAARRR 401
Query: 354 HA 355
HA
Sbjct: 402 HA 403
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 211 bits (537), Expect = 1e-54
Identities = 125/352 (35%), Positives = 196/352 (55%), Gaps = 29/352 (8%)
Query: 29 LGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEV 88
+G+++ ++L V GN+LVI ++A L +VT+Y+I +LA ADL++ V+PF A +
Sbjct: 36 MGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHIL 95
Query: 89 LGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALL 148
+ W FG +C W ++DVLC TASI LC+I++DRY ++ P +Y +++T+ + + +L
Sbjct: 96 MKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIIL 155
Query: 149 CVWALSLVISIGPL-FGWRQPAPED-------ETICQINEEPGYVLFSALGSFYLPLAII 200
VW +S + S P+ W + ++ ET C Y + S++ SFY+PL I+
Sbjct: 156 MVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIM 215
Query: 201 LVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVR 260
+ +Y RV+ AKR+ + K DKS+ R H +N S + H R
Sbjct: 216 VFVYSRVFQEAKRQLQ------KIDKSEG-----RFHVQNL----SQVEQDGRTGHGLRR 260
Query: 261 LLKFS-REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNS 319
KF +E KA KTLGI++G F LCWLPFF+V I D + V+ ++ W+GY+NS
Sbjct: 261 SSKFCLKEHKALKTLGIIMGTFTLCWLPFFIV-NIVHVIQDNLIRKEVYILLNWIGYVNS 319
Query: 320 CINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQH 371
NP+IY C S +F+ AFQ +L CL R + GY+ + + G H
Sbjct: 320 GFNPLIY-CRSPDFRIAFQELL---CLRRSSLKAYGNGYSSNGNTGEQSGYH 367
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 210 bits (534), Expect = 3e-54
Identities = 129/370 (34%), Positives = 194/370 (52%), Gaps = 39/370 (10%)
Query: 7 NASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIV 66
N+SD N T + IL+ + L GL L N LVI ++ R LH +Y I
Sbjct: 5 NSSDQ-NLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLIC 63
Query: 67 NLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYI 126
+LAV D L+ V+PFS ++ V W G+V C+IW +VD+ CCT SI+ L I++DRY
Sbjct: 64 SLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYR 123
Query: 127 GVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVL 186
++ + Y T + + + VW +S+ IS+ PLF Q D+ ++ +
Sbjct: 124 AITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTI 183
Query: 187 FSALGSFYLPLAIILVMYCRVY-------------VVAKRESRG---LKSGLKTDKSDSE 230
+S G+FY+PLA+IL++Y ++Y +AK E G L+SG K+ KS S
Sbjct: 184 YSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVST 243
Query: 231 QVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF---------------SREKKAAKTLG 275
L S ++ K H +VR L+ +RE+KAA TLG
Sbjct: 244 SYVLE-------KSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLG 296
Query: 276 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKK 335
+++G FV+CWLPFF+ + + K SE + + WLGYLNS INP+IY +++FKK
Sbjct: 297 LILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKK 356
Query: 336 AFQNVLRIQC 345
AFQ ++R +C
Sbjct: 357 AFQKLVRCRC 366
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 209 bits (532), Expect = 4e-54
Identities = 125/356 (35%), Positives = 196/356 (55%), Gaps = 26/356 (7%)
Query: 7 NASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIV 66
NA+++S P + I L V+L + L VL N V+ ++ R LH+ +Y I
Sbjct: 21 NATETSEAWDPRTLQALK--ISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIG 78
Query: 67 NLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYI 126
+LA DLL++ V+P S + + W FG++ C+IW + D+ CCTASI+ LC+I++DRY
Sbjct: 79 SLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYW 138
Query: 127 GVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQ-PAPEDETICQIN-EEPGY 184
++ L Y T + VWA+S+ ISI PLF WRQ A E+ + C +N + Y
Sbjct: 139 AITDALEYSKRRTAGHAATMIAIVWAISICISIPPLF-WRQAKAQEEMSDCLVNTSQISY 197
Query: 185 VLFSALGSFYLPLAIILVMYCRVYVVAKRE---------SRGLKSGLKTDKSDSEQVTLR 235
++S G+FY+P +++++Y R+Y A+ R + L T + S +L
Sbjct: 198 TIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLN 257
Query: 236 --IHRKNAPAGGSGMASAKTKTHFSVRLLK-----FSREKKAAKTLGIVVGCFVLCWLPF 288
+H ++ + GS + K + L+ +RE+KA K LGI++G F++CWLPF
Sbjct: 258 SSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPF 317
Query: 289 F---LVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
F LV+PI P+ +F WLGYLNS INPIIY ++EF++AFQ ++
Sbjct: 318 FVVSLVLPICRDSCWIHPA--LFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 207 bits (527), Expect = 2e-53
Identities = 124/348 (35%), Positives = 190/348 (54%), Gaps = 37/348 (10%)
Query: 22 NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-VTHYYIVNLAVADLLLTSTVL 80
+ S IL L LIL +LGN LV +V RHL S VT++++++LAV+DLL+ V+
Sbjct: 19 DFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVM 78
Query: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ 140
P+ A+ E+ G+W FG FCNIW A D++C TASI+ LC+IS+DRY +S P RY +T
Sbjct: 79 PWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTP 137
Query: 141 RRGLMALLCVWALSLVISIGPL-FGWRQPAPED----------ETI--CQINEEPGYVLF 187
+ + + W LS++IS P+ W + P ETI C + Y +
Sbjct: 138 KAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAIS 197
Query: 188 SALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN---APAG 244
S++ SFY+P+AI++V Y R+Y +A+++ R + + + +H KN
Sbjct: 198 SSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERA----------AVHAKNCQTTTGN 247
Query: 245 GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF-----FP 299
G + ++ ++ F + F RE K KTL +++G FV CWLPFF++ I F
Sbjct: 248 GKPVECSQPESSFK---MSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQ 304
Query: 300 DFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLC 347
F F + W G+ NS +NPIIY ++ +F+KAF +L LC
Sbjct: 305 PFCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFSTLLGCYRLC 351
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 202 bits (513), Expect = 7e-52
Identities = 120/335 (35%), Positives = 176/335 (52%), Gaps = 13/335 (3%)
Query: 25 KAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSA 84
+A L G +L +L V GN+LVI+++A L ++T+ ++ +LA ADL++ V+P +A
Sbjct: 36 EAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAA 95
Query: 85 IFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGL 144
+ G+W G C +W +VDVLC TASI LC +++DRY+ V+ PLRY +VT+R
Sbjct: 96 TLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCAR 155
Query: 145 MALLCVWALSLVISIGPLFG--WRQPAPEDETICQIN-------EEPGYVLFSALGSFYL 195
A++ VW +S +S P+ WR A + C N YVL S+ SFYL
Sbjct: 156 TAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYL 215
Query: 196 PLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKT 255
PL ++L +Y RV+VVA R+ R L+ L + AP G
Sbjct: 216 PLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPAC 275
Query: 256 HFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLG 315
L RE +A TLG+++G F LCWLPFFL + + F + WLG
Sbjct: 276 GRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLG 335
Query: 316 YLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ 350
Y NS NP+IY C S +F+ AF+ R+ C C ++
Sbjct: 336 YANSAFNPLIY-CRSPDFRSAFR---RLLCRCGRR 366
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 201 bits (512), Expect = 9e-52
Identities = 123/370 (33%), Positives = 194/370 (52%), Gaps = 38/370 (10%)
Query: 12 SNCTQPPA----PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVN 67
+NCT + P I++ +L+ + L + L N+ VI+++ + LH +Y I +
Sbjct: 4 TNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICS 63
Query: 68 LAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIG 127
LAV DLL+ V+P S I+ V+ W G C +W +VD+ CCT SI+ LC+I++DRY
Sbjct: 64 LAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWA 123
Query: 128 VSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWR-----QPAPEDETICQINEEP 182
++ + Y T +R + +L VW +S+ IS+ PLF WR P P TI ++
Sbjct: 124 ITNAIEYARKRTAKRAALMILTVWTISIFISMPPLF-WRSHRRLSPPPSQCTI--QHDHV 180
Query: 183 GYVLFSALGSFYLPLAIILVMYCRVYVVAKR--ESRGLKSGLKTDKSDSEQVTLRIHRKN 240
Y ++S LG+FY+PL +IL++Y R+Y AK + RG L +DS+
Sbjct: 181 IYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQ 240
Query: 241 APAGGSGMASAKT----KTHFSVRLLKF---------------SREKKAAKTLGIVVGCF 281
S T K H S+R+ F +RE+KAA+ LG+++G F
Sbjct: 241 TFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAF 300
Query: 282 VLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
+L WLPFF+ I + S V + WLGY+NS INP++Y +++FK AF+ ++
Sbjct: 301 ILSWLPFFIKELIVG-LSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLI 359
Query: 342 RIQCLCRKQS 351
R CR+ +
Sbjct: 360 R----CREHT 365
>gi|4503391 dopamine receptor D5 [Homo sapiens]
Length = 477
Score = 201 bits (511), Expect = 1e-51
Identities = 131/381 (34%), Positives = 197/381 (51%), Gaps = 60/381 (15%)
Query: 6 GNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-VTHYY 64
GNA S P P + A LL + LI++ +LGN+LV ++ RHL + +T+ +
Sbjct: 24 GNAVGGSAGAPPLGPSQVVTACLLTL----LIIWTLLGNVLVCAAIVRSRHLRANMTNVF 79
Query: 65 IVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR 124
IV+LAV+DL + V+P+ A+ EV GYW FG FC++W A D++C TASI+ LC+IS+DR
Sbjct: 80 IVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVISVDR 138
Query: 125 YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ---------------- 167
Y +S P RY +TQR L+ + W LS++IS P+ W +
Sbjct: 139 YWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLA 198
Query: 168 ---PAPEDETICQINEE-------PGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRG 217
P ED +N E Y + S+L SFY+P+AI++V Y R+Y +A+ + R
Sbjct: 199 NWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRR 258
Query: 218 LKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIV 277
+ S + A S +SA S+R +E K KTL ++
Sbjct: 259 ISS----------------LERAAEHAQSCRSSAACAPDTSLR-ASIKKETKVLKTLSVI 301
Query: 278 VGCFVLCWLPFFL---VMPIGSFFPDFKP------SETVFKIVFWLGYLNSCINPIIYPC 328
+G FV CWLPFF+ ++P S P+ P SET F + W G+ NS +NP+IY
Sbjct: 302 MGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAF 361
Query: 329 SSQEFKKAFQNVLRIQCLCRK 349
++ +F+K F +L C +
Sbjct: 362 NA-DFQKVFAQLLGCSHFCSR 381
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 201 bits (510), Expect = 2e-51
Identities = 122/359 (33%), Positives = 185/359 (51%), Gaps = 48/359 (13%)
Query: 4 LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
++ N + SS C A I + V+L LIL V GN++V L+V +R L ++T+
Sbjct: 1 MAPNGTASSFCLDSTAC-----KITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNC 55
Query: 64 YIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISID 123
+IV+LA+ DLLL VLPFSAI+++ W+FG+VFCNI+ ++DV+ CTASI+ L +IS+D
Sbjct: 56 FIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLD 115
Query: 124 RYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWR-----QPAPEDETICQ 177
RY V PLRYP +VT R ++L+ +W +S+ +S + GW + C+
Sbjct: 116 RYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCK 175
Query: 178 INEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIH 237
+ Y L L +FYLPL I+ + Y R++ VA+ +
Sbjct: 176 VQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQ----------------------- 212
Query: 238 RKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF 297
AK H S RE KA TL V+G F++CW P+F
Sbjct: 213 -------------AKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGL 259
Query: 298 FPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHAL 356
D +E + IV WLGY NS +NPI+Y +++F+ +Q + + L + S K +L
Sbjct: 260 RGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCR-LANRNSHKTSL 317
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 201 bits (510), Expect = 2e-51
Identities = 122/359 (33%), Positives = 185/359 (51%), Gaps = 48/359 (13%)
Query: 4 LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
++ N + SS C A I + V+L LIL V GN++V L+V +R L ++T+
Sbjct: 1 MAPNGTASSFCLDSTAC-----KITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNC 55
Query: 64 YIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISID 123
+IV+LA+ DLLL VLPFSAI+++ W+FG+VFCNI+ ++DV+ CTASI+ L +IS+D
Sbjct: 56 FIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLD 115
Query: 124 RYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWR-----QPAPEDETICQ 177
RY V PLRYP +VT R ++L+ +W +S+ +S + GW + C+
Sbjct: 116 RYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCK 175
Query: 178 INEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIH 237
+ Y L L +FYLPL I+ + Y R++ VA+ +
Sbjct: 176 VQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQ----------------------- 212
Query: 238 RKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF 297
AK H S RE KA TL V+G F++CW P+F
Sbjct: 213 -------------AKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGL 259
Query: 298 FPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHAL 356
D +E + IV WLGY NS +NPI+Y +++F+ +Q + + L + S K +L
Sbjct: 260 RGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCR-LANRNSHKTSL 317
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 198 bits (504), Expect = 8e-51
Identities = 120/333 (36%), Positives = 179/333 (53%), Gaps = 33/333 (9%)
Query: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAF 94
LIL V GN LV ++V R L + T+Y +V+LAVADLL+ + V+P+ EV G W F
Sbjct: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
Query: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ---RRGLMALLCVW 151
R+ C+++ +DV+ CTASI+ LC ISIDRY V P+ Y Q RR + + VW
Sbjct: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
Query: 152 ALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211
L+ +S LFG+ D T+C I+ P +V++S++ SFYLP + +++Y R+YVV
Sbjct: 159 VLAFAVSCPLLFGFNTTG--DPTVCSISN-PDFVIYSSVVSFYLPFGVTVLVYARIYVVL 215
Query: 212 KRESR------------GLKSGLKTDKSDSEQVTLRIHR-----KNAPAGGSGMASA--- 251
K+ R ++ G + L + R ++ GG G
Sbjct: 216 KQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGE 275
Query: 252 ---KTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVF 308
+ KT S+ L REKKA + + IV+G F++CWLPFFL + + S ++
Sbjct: 276 LKREEKTRNSLMPL---REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELY 332
Query: 309 KIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
WLGY+NS +NP+IY + EF+KAF +L
Sbjct: 333 SATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 365
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 194 bits (494), Expect = 1e-49
Identities = 113/339 (33%), Positives = 180/339 (53%), Gaps = 8/339 (2%)
Query: 4 LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
L N S + +P +P+ +L+ +LG L+ N+LV+ ++ R H V H
Sbjct: 18 LETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHN 77
Query: 64 YIVNLAVADLLLTSTVLPFSAIFEVLGY-WAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
+ ++AV+D+L+ + V+P S + E+ G W GR C +W A DVLCCTASI + I++
Sbjct: 78 LVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIAL 137
Query: 123 DRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGP-LFGWRQPAPEDETICQINEE 181
DRY ++ + Y + + + WALS VIS+ P LFGW + E CQ++ E
Sbjct: 138 DRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSRE 197
Query: 182 PGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNA 241
P Y +FS +G+FYLPL ++L +Y ++Y AK K+ + S++ +V
Sbjct: 198 PSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVK---DSAKQ 254
Query: 242 PAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDF 301
P + A + +E++AA +GI++G FVLCW+PFFL I
Sbjct: 255 PQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCD 314
Query: 302 KPSETVFKIVF-WLGYLNSCINPIIYPCSSQEFKKAFQN 339
P+ ++K +F WLGY NS NP+IY ++ + AF+N
Sbjct: 315 IPA--IWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKN 351
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 188 bits (478), Expect = 8e-48
Identities = 121/363 (33%), Positives = 181/363 (49%), Gaps = 60/363 (16%)
Query: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAF 94
LIL V GN LV ++V R L + T+Y +V+LAVADLL+ + V+P+ EV G W F
Sbjct: 39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNF 98
Query: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ---RRGLMALLCVW 151
R+ C+++ +DV+ CTASI+ LC ISIDRY V P+ Y Q RR + + VW
Sbjct: 99 SRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVW 158
Query: 152 ALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA 211
L+ +S LFG+ D T+C I+ P +V++S++ SFYLP + +++Y R+YVV
Sbjct: 159 VLAFAVSCPLLFGFNTTG--DPTVCSIS-NPDFVIYSSVVSFYLPFGVTVLVYARIYVVL 215
Query: 212 KRESR------------GLKSGLKTDKSDSEQVTLRIHR-----KNAPAGGSGM------ 248
K+ R ++ G + L + R ++ GG G
Sbjct: 216 KQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGE 275
Query: 249 --ASAKTKT--------HFSVRLLKFS--------------------REKKAAKTLGIVV 278
KT+ S+ + K S REKKA + + IV+
Sbjct: 276 LKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVL 335
Query: 279 GCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQ 338
G F++CWLPFFL + + S ++ WLGY+NS +NP+IY + EF+KAF
Sbjct: 336 GAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFL 395
Query: 339 NVL 341
+L
Sbjct: 396 KIL 398
>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
Length = 414
Score = 178 bits (451), Expect = 1e-44
Identities = 119/374 (31%), Positives = 185/374 (49%), Gaps = 73/374 (19%)
Query: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95
LI V GN+LV ++V+ + L + T+Y IV+LAVADLL+ + V+P+ EV+G W F
Sbjct: 44 LIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFS 103
Query: 96 RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALL-CVWALS 154
R+ C+I+ +DV+ CTASI+ LC ISIDRY V+ P+ Y T + +R + ++ VW LS
Sbjct: 104 RIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLS 163
Query: 155 LVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVV---- 210
IS LFG D+ C I P +V++S++ SFY+P + L++Y ++Y+V
Sbjct: 164 FTISCPLLFGLNN---ADQNEC-IIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRR 219
Query: 211 -----AKRESRGLKSGLKTDKSDS------------------------------EQVTL- 234
KR SR ++ L+ ++ Q+TL
Sbjct: 220 RKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLP 279
Query: 235 -----RIH-RKNAPA----GGSGMASAKTKTHFSVRLLKFSREKKAAKT----------- 273
+H ++PA G K F ++ + + + + KT
Sbjct: 280 DPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKE 339
Query: 274 ------LGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYP 327
L IV+G F++CWLPFF + I + D ++ WLGY+NS +NPIIY
Sbjct: 340 KKATQMLAIVLGVFIICWLPFF-ITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYT 398
Query: 328 CSSQEFKKAFQNVL 341
+ EF+KAF +L
Sbjct: 399 TFNIEFRKAFLKIL 412
>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
Length = 387
Score = 177 bits (448), Expect = 2e-44
Identities = 122/390 (31%), Positives = 188/390 (48%), Gaps = 61/390 (15%)
Query: 22 NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV-THYYIVNLAVADLLLTSTVL 80
++ K +LL L +IL +LGN+LV+++V R L + T+Y+IV+LA ADLL++ V+
Sbjct: 16 SVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVM 74
Query: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGV-SYPLRYPTIVT 139
PF AI V W +G VFC + ++DVL TASI LC IS+DRY + PL Y +T
Sbjct: 75 PFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134
Query: 140 QRRGLMALLCVWALSLVISIGPLF-GWRQPAPED------------ETICQINEEPGYVL 186
R + L W + IS P+ GW D T C Y +
Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194
Query: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS 246
++ +FY+P ++++ Y R+YV AK + ++ + R A +
Sbjct: 195 TCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ---------------MLQRAGASSESR 239
Query: 247 GMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSET 306
++ + TH + E KAAKTL I++GCF LCW PFF+ + F D+
Sbjct: 240 PQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI-DYTVPGQ 292
Query: 307 VFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL---------------RIQCLCRK-Q 350
V+ WLGY+NS +NP +Y ++ F++AF +L + C
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTIN 352
Query: 351 SSKHALGYT-LHPPSQAVEGQHKDMVRIPV 379
S H L YT LH G H+++ ++P+
Sbjct: 353 GSTHVLRYTVLH------RGHHQELEKLPI 376
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 174 bits (442), Expect = 1e-43
Identities = 111/335 (33%), Positives = 170/335 (50%), Gaps = 38/335 (11%)
Query: 22 NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV-THYYIVNLAVADLLLTSTVL 80
++ K +LL L +IL +LGN+LV+++V R L + T+Y+IV+LA ADLL++ V+
Sbjct: 16 SVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVM 74
Query: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGV-SYPLRYPTIVT 139
PF AI V W +G VFC + ++DVL TASI LC IS+DRY + PL Y +T
Sbjct: 75 PFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134
Query: 140 QRRGLMALLCVWALSLVISIGPLF-GWRQPAPED------------ETICQINEEPGYVL 186
R + L W + IS P+ GW D T C Y +
Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194
Query: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS 246
++ +FY+P ++++ Y R+YV AK + ++ + R A +
Sbjct: 195 TCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ---------------MLQRAGASSESR 239
Query: 247 GMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSET 306
++ + TH + E KAAKTL I++GCF LCW PFF+ + F D+
Sbjct: 240 PQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI-DYTVPGQ 292
Query: 307 VFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
V+ WLGY+NS +NP +Y ++ F++AF +L
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL 327
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 174 bits (442), Expect = 1e-43
Identities = 111/335 (33%), Positives = 170/335 (50%), Gaps = 38/335 (11%)
Query: 22 NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV-THYYIVNLAVADLLLTSTVL 80
++ K +LL L +IL +LGN+LV+++V R L + T+Y+IV+LA ADLL++ V+
Sbjct: 16 SVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVM 74
Query: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGV-SYPLRYPTIVT 139
PF AI V W +G VFC + ++DVL TASI LC IS+DRY + PL Y +T
Sbjct: 75 PFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134
Query: 140 QRRGLMALLCVWALSLVISIGPLF-GWRQPAPED------------ETICQINEEPGYVL 186
R + L W + IS P+ GW D T C Y +
Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194
Query: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS 246
++ +FY+P ++++ Y R+YV AK + ++ + R A +
Sbjct: 195 TCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ---------------MLQRAGASSESR 239
Query: 247 GMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSET 306
++ + TH + E KAAKTL I++GCF LCW PFF+ + F D+
Sbjct: 240 PQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI-DYTVPGQ 292
Query: 307 VFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
V+ WLGY+NS +NP +Y ++ F++AF +L
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL 327
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 174 bits (442), Expect = 1e-43
Identities = 111/335 (33%), Positives = 170/335 (50%), Gaps = 38/335 (11%)
Query: 22 NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV-THYYIVNLAVADLLLTSTVL 80
++ K +LL L +IL +LGN+LV+++V R L + T+Y+IV+LA ADLL++ V+
Sbjct: 16 SVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVM 74
Query: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGV-SYPLRYPTIVT 139
PF AI V W +G VFC + ++DVL TASI LC IS+DRY + PL Y +T
Sbjct: 75 PFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134
Query: 140 QRRGLMALLCVWALSLVISIGPLF-GWRQPAPED------------ETICQINEEPGYVL 186
R + L W + IS P+ GW D T C Y +
Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194
Query: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS 246
++ +FY+P ++++ Y R+YV AK + ++ + R A +
Sbjct: 195 TCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ---------------MLQRAGASSESR 239
Query: 247 GMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSET 306
++ + TH + E KAAKTL I++GCF LCW PFF+ + F D+
Sbjct: 240 PQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI-DYTVPGQ 292
Query: 307 VFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
V+ WLGY+NS +NP +Y ++ F++AF +L
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL 327
>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
Length = 378
Score = 174 bits (442), Expect = 1e-43
Identities = 111/335 (33%), Positives = 170/335 (50%), Gaps = 38/335 (11%)
Query: 22 NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV-THYYIVNLAVADLLLTSTVL 80
++ K +LL L +IL +LGN+LV+++V R L + T+Y+IV+LA ADLL++ V+
Sbjct: 16 SVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVM 74
Query: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGV-SYPLRYPTIVT 139
PF AI V W +G VFC + ++DVL TASI LC IS+DRY + PL Y +T
Sbjct: 75 PFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134
Query: 140 QRRGLMALLCVWALSLVISIGPLF-GWRQPAPED------------ETICQINEEPGYVL 186
R + L W + IS P+ GW D T C Y +
Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194
Query: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS 246
++ +FY+P ++++ Y R+YV AK + ++ + R A +
Sbjct: 195 TCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ---------------MLQRAGASSESR 239
Query: 247 GMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSET 306
++ + TH + E KAAKTL I++GCF LCW PFF+ + F D+
Sbjct: 240 PQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI-DYTVPGQ 292
Query: 307 VFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
V+ WLGY+NS +NP +Y ++ F++AF +L
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL 327
>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
Length = 388
Score = 174 bits (442), Expect = 1e-43
Identities = 111/335 (33%), Positives = 170/335 (50%), Gaps = 38/335 (11%)
Query: 22 NISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV-THYYIVNLAVADLLLTSTVL 80
++ K +LL L +IL +LGN+LV+++V R L + T+Y+IV+LA ADLL++ V+
Sbjct: 16 SVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVM 74
Query: 81 PFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGV-SYPLRYPTIVT 139
PF AI V W +G VFC + ++DVL TASI LC IS+DRY + PL Y +T
Sbjct: 75 PFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMT 134
Query: 140 QRRGLMALLCVWALSLVISIGPLF-GWRQPAPED------------ETICQINEEPGYVL 186
R + L W + IS P+ GW D T C Y +
Sbjct: 135 PLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAI 194
Query: 187 FSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGS 246
++ +FY+P ++++ Y R+YV AK + ++ + R A +
Sbjct: 195 TCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ---------------MLQRAGASSESR 239
Query: 247 GMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSET 306
++ + TH + E KAAKTL I++GCF LCW PFF+ + F D+
Sbjct: 240 PQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFI-DYTVPGQ 292
Query: 307 VFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
V+ WLGY+NS +NP +Y ++ F++AF +L
Sbjct: 293 VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL 327
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.139 0.436
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,647,776
Number of Sequences: 37866
Number of extensions: 746648
Number of successful extensions: 4359
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 637
Number of HSP's successfully gapped in prelim test: 132
Number of HSP's that attempted gapping in prelim test: 2239
Number of HSP's gapped (non-prelim): 1358
length of query: 466
length of database: 18,247,518
effective HSP length: 106
effective length of query: 360
effective length of database: 14,233,722
effective search space: 5124139920
effective search space used: 5124139920
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.