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Search of human proteins with 11095441
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
(535 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 1067 0.0
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 223 3e-58
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 223 4e-58
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 221 1e-57
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 221 2e-57
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 220 2e-57
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 217 2e-56
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 206 3e-53
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 198 9e-51
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 189 5e-48
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 188 9e-48
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 184 2e-46
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 181 1e-45
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 180 3e-45
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 173 4e-43
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 155 1e-37
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 105 1e-22
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 103 5e-22
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 103 5e-22
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 103 5e-22
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 94 2e-19
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens] 94 2e-19
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 94 4e-19
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 94 4e-19
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 89 8e-18
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 89 8e-18
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 89 8e-18
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 84 3e-16
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 84 3e-16
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 84 3e-16
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 1067 bits (2760), Expect = 0.0
Identities = 535/535 (100%), Positives = 535/535 (100%)
Query: 1 MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIH 60
MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIH
Sbjct: 1 MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIH 60
Query: 61 NPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIA 120
NPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIA
Sbjct: 61 NPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIA 120
Query: 121 KLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCA 180
KLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCA
Sbjct: 121 KLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCA 180
Query: 181 GIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHG 240
GIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHG
Sbjct: 181 GIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHG 240
Query: 241 QHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKEN 300
QHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKEN
Sbjct: 241 QHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKEN 300
Query: 301 TLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLIT 360
TLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLIT
Sbjct: 301 TLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLIT 360
Query: 361 PQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFG 420
PQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFG
Sbjct: 361 PQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFG 420
Query: 421 PVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLP 480
PVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLP
Sbjct: 421 PVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLP 480
Query: 481 MFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR 535
MFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR
Sbjct: 481 MFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR 535
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 223 bits (569), Expect = 3e-58
Identities = 150/478 (31%), Positives = 237/478 (49%), Gaps = 13/478 (2%)
Query: 43 FIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQ 102
FI GKF+ S +ID ++P+T EV RVP + K E++AA+ + + AFP+W+ S R
Sbjct: 13 FIDGKFLPCSS--YIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERS 70
Query: 103 QVLLRYQQLIKENLKEIAKLITLEQGKTLADAEG-DVFRGLQVVEHACSVTSLMMGETMP 161
+VL + L++++L+E A+ + +QGKTLA A D+ R +Q S + E
Sbjct: 71 RVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQ 130
Query: 162 SITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLL 221
Y+ R P+GV I+P+N P + W AM GNT + KPSE +L
Sbjct: 131 MDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWML 190
Query: 222 AKLLQDSGAPDGTLNIIHGQHEAV-NFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRV 280
KLL +G P G +NI+ G V + HP++ ISF GS E I + + H K++
Sbjct: 191 CKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKL 250
Query: 281 QANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTA-VLVGEAKKWLPELVEH 339
+G KN ++ DAN + + V ++F G+ C+ S V ++L VE
Sbjct: 251 SLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEA 310
Query: 340 AKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASIL----LDGRKIKVKGYEN 395
+ +V P +G LI+ E+V + + EGA I +D + + +
Sbjct: 311 TRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARN-QA 369
Query: 396 GNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGA 455
G F+ PT+I+++K C EEIFGPV V+ ++ +E I+ NN YG ++++N
Sbjct: 370 GYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVG 429
Query: 456 TARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTIT 513
+ A + G V N + L + F G +SS G K F+T++KTIT
Sbjct: 430 RVHRVAKKLQSGLVWTNCWLIRELNL-PFGGMKSSGIGREG--AKDSYDFFTEIKTIT 484
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 223 bits (567), Expect = 4e-58
Identities = 151/486 (31%), Positives = 244/486 (50%), Gaps = 19/486 (3%)
Query: 37 VPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPA---W 93
V K+FI ++ ESKS K NP+T E I V + K ++D A+ + + AF W
Sbjct: 29 VKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPW 88
Query: 94 ADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRG-LQVVEHACSVT 152
LSR ++L + L++ + +A L T++ GK A G ++ + +
Sbjct: 89 RRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWA 148
Query: 153 SLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSE 212
+ G+T+P+ ++ ++ P+GVC I P+NFP ++ +W A+ CGNT ++KP+E
Sbjct: 149 DKIQGKTIPT-DDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAE 207
Query: 213 RVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVN-FICDHPDIKAISFVGSNKAGEYIFE 271
+ P + L L++++G P G +NI+ G V I HP I I+F GS + G+ + E
Sbjct: 208 QTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKE 267
Query: 272 RGSRHG-KRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEA- 329
SR KRV +G KN +V DA+ + + F GQ C A S + +
Sbjct: 268 AASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVY 327
Query: 330 KKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIK 389
+++ VE+AK V + GP I + +++ LI+SG KEGA + G ++
Sbjct: 328 SEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAME 387
Query: 390 VKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAI 449
KG F+ PT+ S V NM KEEIFGPV +L+ ++++E I+ N+ YG A+
Sbjct: 388 DKGL----FIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAV 443
Query: 450 FTTNGATARKYAHLVDVGQVGVNV--PIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYT 507
FT N A K A ++ G V +N + P F S G+ G+ + YT
Sbjct: 444 FTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMS-----GNGRELGEYALAEYT 498
Query: 508 QLKTIT 513
++KT+T
Sbjct: 499 EVKTVT 504
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 221 bits (563), Expect = 1e-57
Identities = 155/517 (29%), Positives = 252/517 (48%), Gaps = 15/517 (2%)
Query: 4 LLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPA 63
+L A R LQ + SS + + +P +LFI ++ ++ S K NP
Sbjct: 1 MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT 60
Query: 64 TNEVIGRVPQATKAEMDAAIASCKRAF---PAWADTSVLSRQQVLLRYQQLIKENLKEIA 120
T EVIG V + +A++D A+ + + AF W R ++L R L++ + +A
Sbjct: 61 TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLA 120
Query: 121 KLITLEQGKTLADAEG-DVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVC 179
L TL+ GK ++ D+ ++V + G+T+P + ++ P+GVC
Sbjct: 121 SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHF-CFTRHEPVGVC 179
Query: 180 AGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIH 239
I P+NFP ++ W A+ GNT +MK +E+ P + + LA L++++G P G +NII
Sbjct: 180 GQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIIT 239
Query: 240 GQHEAVN-FICDHPDIKAISFVGSNKAGEYIFE-RGSRHGKRVQANMGAKNHGVVMPDAN 297
G I H D+ ++F GS + G I + G + KRV +G K+ +V+ DA+
Sbjct: 240 GYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADAD 299
Query: 298 KENTLNQLVGAAFGAAGQRCMALS-TAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLG 356
E+ + Q A F GQ C A S T V ++L VE AK +V + G
Sbjct: 300 MEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQG 359
Query: 357 PLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKE 416
P + + ERV I G KEGA +L G + +G+ F+ PT+ V+ +M KE
Sbjct: 360 PQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGF----FIKPTVFGGVQDDMRIAKE 415
Query: 417 EIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIP 476
EIFGPV + + + ++E ++ NN YG A+FT + A + + G V VN
Sbjct: 416 EIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNT-YN 474
Query: 477 VPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTIT 513
+ F G + S G+ G+ G++ YT++KT+T
Sbjct: 475 IVTCHTPFGGFKES--GNGRELGEDGLKAYTEVKTVT 509
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 221 bits (562), Expect = 2e-57
Identities = 150/489 (30%), Positives = 251/489 (51%), Gaps = 17/489 (3%)
Query: 41 KLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPA---WADTS 97
K+FI ++ +S S K + NPAT E + +V + K ++D A+ + ++AF W
Sbjct: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81
Query: 98 VLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAE-GDVFRGLQVVEHACSVTSLMM 156
R ++L + LI+ + +A + ++ GK ++A D+ ++ + + +
Sbjct: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141
Query: 157 GETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPG 216
G T+P I + Y+ P+GVC I P+NFP ++ +W A+ CGNT ++KP+E+ P
Sbjct: 142 GRTIP-IDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200
Query: 217 ATMLLAKLLQDSGAPDGTLNIIHGQHEAVN-FICDHPDIKAISFVGSNKAGEYIFE-RGS 274
+ +A L++++G P G +NI+ G I H DI ++F GS + G+ I E G
Sbjct: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK 260
Query: 275 RHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEA--KKW 332
+ KRV +G K+ +V+ DA+ +N + F GQ C+A S + V E+ ++
Sbjct: 261 SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAAS-RIFVEESIYDEF 319
Query: 333 LPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKG 392
+ VE AK + PG GP I + +++ +LI+SG KEGA + G KG
Sbjct: 320 VRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKG 379
Query: 393 YENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTT 452
Y FV PT+ SNV M KEEIFGPV +++ ++LD+ I+ NN YG +FT
Sbjct: 380 Y----FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435
Query: 453 NGATARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTI 512
+ A + + G V VN V F G + S G+ G+ G YT++KT+
Sbjct: 436 DIDKAITISSALQAGTVWVNC-YGVVSAQCPFGGFKMS--GNGRELGEYGFHEYTEVKTV 492
Query: 513 TSQWKEEDA 521
T + ++++
Sbjct: 493 TVKISQKNS 501
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 220 bits (561), Expect = 2e-57
Identities = 151/512 (29%), Positives = 253/512 (49%), Gaps = 16/512 (3%)
Query: 10 VRARILQVSSKVKS-SPTWYSASSFSSSVPTVKL-FIGGKFVESKSDKWID-IHNPATNE 66
+RA + +S ++S P+ +A S + V + L + GG VE + PAT
Sbjct: 3 LRAGLAALSPLLRSLRPSPVAAMSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGR 62
Query: 67 VIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLE 126
VI + + E++ A+ + K AF W+ S + R ++LL ++I+E EIA + +
Sbjct: 63 VIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECIN 122
Query: 127 QGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFN 186
GK++ +A D+ Q +E+ + + M GE + + Y+ R PLGVC GI +N
Sbjct: 123 NGKSIFEARLDIDISWQCLEYYAGLAASMAGEHI-QLPGGSFGYTRREPLGVCVGIGAWN 181
Query: 187 FPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVN 246
+P I W A+ CGN + KPS P + +LLA++ ++G P G N++ G
Sbjct: 182 YPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQ 241
Query: 247 FICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLV 306
F+C HPD+ +SF GS G I E ++ K V +G K+ ++ D + N + +
Sbjct: 242 FLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGAL 301
Query: 307 GAAFGAAGQRCMALSTAVLVGE--AKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAK 364
A F GQ C T V V + K+ E+V+ + +++ +GPLI
Sbjct: 302 MANFLTQGQVC-CNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHL 360
Query: 365 ERVCNLIDSGTKEGASILLDGRKIKVKG--YENGNFVGPTIISNVKPNMTCYKEEIFGPV 422
ERV + ++GA +L G + ++G ++ P +++N + +MTC KEEIFGPV
Sbjct: 361 ERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPV 420
Query: 423 LVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVN--VPIPVPLP 480
+ +L +T E ++ N+ +G +FT + A + + G +N PV LP
Sbjct: 421 MSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELP 480
Query: 481 MFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTI 512
F G + S G N G+ I++Y+QLKT+
Sbjct: 481 ---FGGYKKSGFGREN--GRVTIEYYSQLKTV 507
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 217 bits (553), Expect = 2e-56
Identities = 150/516 (29%), Positives = 254/516 (49%), Gaps = 28/516 (5%)
Query: 15 LQVSSKVKSSPTWYSASSFSSSVPT-------VKLFIGGKFVESKSDKWIDIHNPATNEV 67
+++ +VK+ P AS PT K+FI ++ S+S + ++NPAT E
Sbjct: 6 IEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQ 65
Query: 68 IGRVPQATKAEMDAAIASCKRAFP---AWADTSVLSRQQVLLRYQQLIKENLKEIAKLIT 124
+ V +A KA++D A+ + + AF W R ++L + L++ + +A + +
Sbjct: 66 VCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMES 125
Query: 125 LEQGKTLADAEGDVFRG-LQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIA 183
L GK A +G ++ + + G T+P + D ++ P+GVC I
Sbjct: 126 LNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIP-VDGDYFTFTRHEPIGVCGQII 184
Query: 184 PFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHE 243
P+NFP ++ W A+ CGNT ++KP+E+ P + + + L++++G P G +NI+ G
Sbjct: 185 PWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGP 244
Query: 244 AVN-FICDHPDIKAISFVGSNKAGEYIFERGSRHG-KRVQANMGAKNHGVVMPDANKENT 301
I H I I+F GS + G+ I E R KRV +G K+ ++ DA+ +
Sbjct: 245 TAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYA 304
Query: 302 LNQLVGAAFGAAGQRCMALSTAVLVGEA--KKWLPELVEHAKNLRVNAGDQPGADLGPLI 359
+ Q F GQ C A + + V E+ ++++ VE AK V + P + GP I
Sbjct: 305 VEQAHQGVFFNQGQCCTA-GSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQI 363
Query: 360 TPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIF 419
+ ++ LI SG EGA + G+ + KG+ F+ PT+ SNV +M KEEIF
Sbjct: 364 DKKQYNKILELIQSGVAEGAKLECGGKGLGRKGF----FIEPTVFSNVTDDMRIAKEEIF 419
Query: 420 GPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNV--PIPV 477
GPV +L +T+DE I+ NN+ +G A+FT + A + + G V +N +
Sbjct: 420 GPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNA 479
Query: 478 PLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTIT 513
P F S G+ G+ G++ Y+++KT+T
Sbjct: 480 QSPFGGFKMS-----GNGREMGEFGLREYSEVKTVT 510
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 206 bits (525), Expect = 3e-53
Identities = 145/485 (29%), Positives = 239/485 (49%), Gaps = 25/485 (5%)
Query: 41 KLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPA---WADTS 97
++FI ++ ++ S K NP+T EVI +V + K ++D A+ + + AF W
Sbjct: 38 QIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMD 97
Query: 98 VLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAE-GDVFRGLQVVEHACSVTSLMM 156
R ++L R LI+ + +A L TL+ GK + D+ L+ + +
Sbjct: 98 ASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYH 157
Query: 157 GETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPG 216
G+T+P I D Y+ P+GVC I P+NFP ++ W A+ GN +MK +E+ P
Sbjct: 158 GKTIP-IDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPL 216
Query: 217 ATMLLAKLLQDSGAPDGTLNIIHGQHEAVNF-ICDHPDIKAISFVGSNKAGEYI-FERGS 274
+ +A L++++G P G +NI+ G I H D+ ++F GS + G I GS
Sbjct: 217 TALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGS 276
Query: 275 RHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALS-TAVLVGEAKKWL 333
+ KRV +G K+ ++M DA+ + + Q A F GQ C A S T V +++
Sbjct: 277 SNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFV 336
Query: 334 PELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGY 393
V AK+ V + GP + +++ I++G +EGA +L G +GY
Sbjct: 337 ERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGY 396
Query: 394 ENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTN 453
F+ PT+ +V+ MT KEEIFGPV+ +L+ +T++E + NN+ YG A+FT +
Sbjct: 397 ----FIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKD 452
Query: 454 GATARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSSF-----RGDTNFYGKQGIQFYTQ 508
A + + G V VN + G++S F G G+ G+Q YT+
Sbjct: 453 LDKANYLSQALQAGTVWVN--------CYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTE 504
Query: 509 LKTIT 513
+KT+T
Sbjct: 505 VKTVT 509
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 198 bits (504), Expect = 9e-51
Identities = 138/489 (28%), Positives = 231/489 (47%), Gaps = 17/489 (3%)
Query: 31 SSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAF 90
+ S+++ F+GG+++ + + + +PA+ +G V E AA+ + AF
Sbjct: 52 AGLSAALLRTDSFVGGRWLPAAAT--FPVQDPASGAALGMVADCGVREARAAVRAAYEAF 109
Query: 91 PAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRGLQVVEHACS 150
W + S R +L ++ L+ +N ++A++IT E GK L +A G++ +E
Sbjct: 110 CRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSE 169
Query: 151 VTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKP 210
+ G+ + + KD + P+GV A I P+NFP+ + A+ G T ++KP
Sbjct: 170 EARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKP 229
Query: 211 SERVPGATMLLAKLLQDSGAPDGTLNII----HGQHEAVNFICDHPDIKAISFVGSNKAG 266
+E P + + LA+L +G P G N+I E IC P + ISF GS G
Sbjct: 230 AEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTG 289
Query: 267 EYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLV 326
+ + + KRV +G +V AN + + + + F GQ C+ S LV
Sbjct: 290 KILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVC-SNQFLV 348
Query: 327 --GEAKKWLPELVE-HAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILL 383
G ++ E KNLRV G + G GPLI +A E+V ++ +GA+++
Sbjct: 349 QRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVT 408
Query: 384 DGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPY 443
G++ ++ NF PT++ NV +M C EE FGP+ V++ +T +EAI I N
Sbjct: 409 GGKRHQL----GKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADV 464
Query: 444 GNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGI 503
G ++ + A + A ++VG VGVN + + F G + S G K GI
Sbjct: 465 GLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL-ISSVECPFGGVKQSGLGREG--SKYGI 521
Query: 504 QFYTQLKTI 512
Y +LK +
Sbjct: 522 DEYLELKYV 530
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 189 bits (480), Expect = 5e-48
Identities = 138/502 (27%), Positives = 231/502 (46%), Gaps = 30/502 (5%)
Query: 31 SSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAF 90
+ S+++ F+GG+++ + + + +PA+ +G V E AA+ + AF
Sbjct: 52 AGLSAALLRTDSFVGGRWLPAAAT--FPVQDPASGAALGMVADCGVREARAAVRAAYEAF 109
Query: 91 PAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRGLQVVEHACS 150
W + S R +L ++ L+ +N ++A++IT E GK L +A G++ +E
Sbjct: 110 CRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSE 169
Query: 151 VTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKP 210
+ G+ + + KD + P+GV A I P+NFP+ + A+ G T ++KP
Sbjct: 170 EARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKP 229
Query: 211 SERVPGATMLLAK-------------LLQDSGAPDGTLNII----HGQHEAVNFICDHPD 253
+E P + + LA+ L +G P G N+I E IC P
Sbjct: 230 AEDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPL 289
Query: 254 IKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAA 313
+ ISF GS G+ + + KRV +G +V AN + + + + F
Sbjct: 290 VSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNT 349
Query: 314 GQRCMALSTAVLV--GEAKKWLPELVE-HAKNLRVNAGDQPGADLGPLITPQAKERVCNL 370
GQ C+ S LV G ++ E KNLRV G + G GPLI +A E+V
Sbjct: 350 GQTCVC-SNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQ 408
Query: 371 IDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETET 430
++ +GA+++ G++ ++ NF PT++ NV +M C EE FGP+ V++ +T
Sbjct: 409 VNDAVSKGATVVTGGKRHQL----GKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDT 464
Query: 431 LDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSS 490
+EAI I N G ++ + A + A ++VG VGVN + + F G + S
Sbjct: 465 EEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL-ISSVECPFGGVKQS 523
Query: 491 FRGDTNFYGKQGIQFYTQLKTI 512
G K GI Y +LK +
Sbjct: 524 GLGREG--SKYGIDEYLELKYV 543
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 188 bits (478), Expect = 9e-48
Identities = 133/488 (27%), Positives = 240/488 (49%), Gaps = 24/488 (4%)
Query: 43 FIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFP--AWADTSVLS 100
FI G+F ++ K D NP I +V A+ A++D A+A+ K AF W +
Sbjct: 446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARE 505
Query: 101 RQQVLLRYQQLIKENLKEIAKLITLEQGKTLADA-EGDVFRGLQVVEHACSVTSLMMGET 159
R +++ R L++EN +E+A + L+ G A + + +Q + + G T
Sbjct: 506 RGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGST 565
Query: 160 MP--SITKDMDL-YSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPG 216
+P + +L ++ + PLGVCA I P+N+P M+ W + GNT ++KP++ P
Sbjct: 566 IPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPL 625
Query: 217 ATMLLAKLLQDSGAPDGTLNIIHGQHE-AVNFICDHPDIKAISFVGSNKAGEYIFER-GS 274
+ A+L +G P G +NII G A + +HPDI+ + F GS G+ I +
Sbjct: 626 TALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAV 685
Query: 275 RHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEA--KKW 332
+ K+V +G K+ ++ D + + +GA F G+ C+A + + V E+ ++
Sbjct: 686 SNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIA-AGRLFVEESIHDEF 744
Query: 333 LPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKG 392
+ +VE K +++ D GP E++ ++G KEGA+++ GR+++ G
Sbjct: 745 VTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPG 804
Query: 393 YENGNFVGPTIISNVKPNMTCYKEEIFGPVLVV--LETETLDEAIQIVNNNPYGNGTAIF 450
+ F+ PT+ ++V+ M KEE FGP++V+ + +D +Q N+ YG + +F
Sbjct: 805 F----FMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVF 860
Query: 451 TTNGATARKYAHLVDVGQVGVNV--PIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQ 508
T + A + ++ G V +N V P F G + S G G++ + Y +
Sbjct: 861 TRDINKAMYVSEKLEAGTVFINTYNKTDVAAP---FGGVKQS--GFGKDLGEEALNEYLK 915
Query: 509 LKTITSQW 516
KT+T ++
Sbjct: 916 TKTVTLEY 923
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 184 bits (467), Expect = 2e-46
Identities = 140/473 (29%), Positives = 216/473 (45%), Gaps = 57/473 (12%)
Query: 43 FIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQ 102
FI GKF+ S +ID ++P+T EV RVP + K E++AA+ + + AFP+W+ S R
Sbjct: 13 FIDGKFLPCSS--YIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERS 70
Query: 103 QVLLRYQQLIKENLKEIAKLITLEQGKTLADAEG-DVFRGLQVVEHACSVTSLMMGETMP 161
+VL + L++++L+E A+ + +QGKTLA A D+ R +Q S + E
Sbjct: 71 RVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQ 130
Query: 162 SITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLL 221
Y+ R P+GV I+P+N P + W AM GNT + KPSE +L
Sbjct: 131 MDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWML 190
Query: 222 AKLLQDSGAPDGTLNIIHGQHEAV-NFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRV 280
KLL +G P G +NI+ G V + HP++ ISF GS E I + + H K++
Sbjct: 191 CKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKL 250
Query: 281 QANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHA 340
+G KN ++ DAN + + V ++F A Q + A+ G A+ W E V+
Sbjct: 251 SLELGGKNPAIIFEDANLDECIPATVRSSF--ANQVRSYVKRALAEG-AQIWCGEGVD-- 305
Query: 341 KNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVG 400
L + A +Q G + P + K+ C
Sbjct: 306 -KLSLPARNQAGYFMLPTVITDIKDESC-------------------------------- 332
Query: 401 PTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKY 460
C EEIFGPV V+ ++ +E I+ NN YG ++++N +
Sbjct: 333 ------------CMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRV 380
Query: 461 AHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTIT 513
A + G V N + L + F G +SS G K F+T++KTIT
Sbjct: 381 AKKLQSGLVWTNCWLIRELNL-PFGGMKSSGIGREG--AKDSYDFFTEIKTIT 430
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 181 bits (459), Expect = 1e-45
Identities = 124/420 (29%), Positives = 209/420 (49%), Gaps = 18/420 (4%)
Query: 101 RQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRG-LQVVEHACSVTSLMMGET 159
R ++L + L++ + +A + +L GK A +G ++ + + G T
Sbjct: 6 RGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMT 65
Query: 160 MPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATM 219
+P + D ++ P+GVC I P+NFP ++ W A+ CGNT ++KP+E+ P + +
Sbjct: 66 IP-VDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSAL 124
Query: 220 LLAKLLQDSGAPDGTLNIIHGQHEAVN-FICDHPDIKAISFVGSNKAGEYIFERGSRHG- 277
+ L++++G P G +NI+ G I H I I+F GS + G+ I E R
Sbjct: 125 YMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNL 184
Query: 278 KRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEA--KKWLPE 335
KRV +G K+ ++ DA+ + + Q F GQ C A + + V E+ ++++
Sbjct: 185 KRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTA-GSRIFVEESIYEEFVRR 243
Query: 336 LVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYEN 395
VE AK V + P + GP I + ++ LI SG EGA + G+ + KG+
Sbjct: 244 SVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGF-- 301
Query: 396 GNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGA 455
F+ PT+ SNV +M KEEIFGPV +L +T+DE I+ NN+ +G A+FT +
Sbjct: 302 --FIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDIN 359
Query: 456 TARKYAHLVDVGQVGVNV--PIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTIT 513
A + + G V +N + P F S G+ G+ G++ Y+++KT+T
Sbjct: 360 KALTVSSAMQAGTVWINCYNALNAQSPFGGFKMS-----GNGREMGEFGLREYSEVKTVT 414
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 180 bits (456), Expect = 3e-45
Identities = 137/515 (26%), Positives = 236/515 (45%), Gaps = 64/515 (12%)
Query: 15 LQVSSKVKSSPTWYSASSFSSSVPT-------VKLFIGGKFVESKSDKWIDIHNPATNEV 67
+++ +VK+ P AS PT K+FI ++ S+S + ++NPAT E
Sbjct: 6 IEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQ 65
Query: 68 IGRVPQATKAEMDAAIASCKRAFP---AWADTSVLSRQQVLLRYQQLIKENLKEIAKLIT 124
+ V +A KA++D A+ + + AF W R ++L + L++ + +A + +
Sbjct: 66 VCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMES 125
Query: 125 LEQGKTLADAEGDVFRG-LQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIA 183
L GK A +G ++ + + G T+P + D ++ P+GVC I
Sbjct: 126 LNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIP-VDGDYFTFTRHEPIGVCGQII 184
Query: 184 PFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHE 243
P+NFP ++ W A+ CGNT ++KP+E+ P + + + L+++
Sbjct: 185 PWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE---------------- 228
Query: 244 AVNFICDHPDIKAISFVGSNKAGEYIFERGSRHG-KRVQANMGAKNHGVVMPDANKENTL 302
G+ I E R KRV +G K+ ++ DA+ + +
Sbjct: 229 ---------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAV 267
Query: 303 NQLVGAAFGAAGQRCMALSTAVLVGEA--KKWLPELVEHAKNLRVNAGDQPGADLGPLIT 360
Q F GQ C A + + V E+ ++++ VE AK V + P + GP I
Sbjct: 268 EQAHQGVFFNQGQCCTA-GSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQID 326
Query: 361 PQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFG 420
+ ++ LI SG EGA + G+ + KG+ F+ PT+ SNV +M KEEIFG
Sbjct: 327 KKQYNKILELIQSGVAEGAKLECGGKGLGRKGF----FIEPTVFSNVTDDMRIAKEEIFG 382
Query: 421 PVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNV--PIPVP 478
PV +L +T+DE I+ NN+ +G A+FT + A + + G V +N +
Sbjct: 383 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ 442
Query: 479 LPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTIT 513
P F S G+ G+ G++ Y+++KT+T
Sbjct: 443 SPFGGFKMS-----GNGREMGEFGLREYSEVKTVT 472
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 173 bits (438), Expect = 4e-43
Identities = 126/490 (25%), Positives = 231/490 (47%), Gaps = 24/490 (4%)
Query: 41 KLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFP--AWADTSV 98
+LFIGG+FV+++ K + NP VI +V A ++D A+A+ K AF W S
Sbjct: 423 QLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISA 482
Query: 99 LSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADA-EGDVFRGLQVVEHACSVTSLMMG 157
R +++ R L++++ +E+A + L+ G A + V +Q + + G
Sbjct: 483 RDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQG 542
Query: 158 ETMP----SITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSER 213
T+P +++ L + + P+GVC I P+N+P M+ W + GNT ++KP++
Sbjct: 543 STIPINQARPNRNLTL-TRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQV 601
Query: 214 VPGATMLLAKLLQDSGAPDGTLNIIHGQHEAV-NFICDHPDIKAISFVGSNKAGEYIFER 272
P + A+L +G P G +N++ G V + DHPD++ I F GS + G++I +
Sbjct: 602 TPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKS 661
Query: 273 -GSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEA-K 330
+ K+V +G K+ ++ D + + + + F G+ C+A +
Sbjct: 662 CAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHD 721
Query: 331 KWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKV 390
+++ +VE + ++V D GP ++ G KEGA+++ G ++
Sbjct: 722 EFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPR 781
Query: 391 KGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVV--LETETLDEAIQIVNNNPYGNGTA 448
G+ F PT+ ++V+ +M KEE FGPV+++ LD + N +G +
Sbjct: 782 PGF----FFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASG 837
Query: 449 IFTTNGATARKYAHLVDVGQVGVNV--PIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFY 506
+FT + A + + G V VN V P F +S F D G+ + Y
Sbjct: 838 VFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGF--KQSGFGKD---LGEAALNEY 892
Query: 507 TQLKTITSQW 516
++KT+T ++
Sbjct: 893 LRVKTVTFEY 902
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 155 bits (391), Expect = 1e-37
Identities = 113/430 (26%), Positives = 194/430 (45%), Gaps = 21/430 (4%)
Query: 57 IDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENL 116
I + PA NE I RV QA+ A+ + + + A+ WAD R +++ + ++E +
Sbjct: 66 ITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKI 125
Query: 117 KEIAKLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPL 176
+ + L++LE GK L + G+V + + ++A ++ ++ G +PS L P+
Sbjct: 126 QVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPV 185
Query: 177 GVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVP----GATMLLAKLLQDSGAPD 232
G+ I FNFP + W +AM+CGN L K + T ++AK+L+D+ P
Sbjct: 186 GLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPG 245
Query: 233 GTLNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVV 292
++ G + + + +SF GS + G+ + R +G N +
Sbjct: 246 AICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIA 305
Query: 293 MPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAK----NLRVNAG 348
DA+ + + AA G AGQRC +TA + + E+V K +RV
Sbjct: 306 FEDADLSLVVPSALFAAVGTAGQRC---TTARRLFIHESIHDEVVNRLKKAYAQIRVGNP 362
Query: 349 DQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVK 408
P GPL T QA ++ KEG +++ G+ + GN+V PTI++ +
Sbjct: 363 WDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMD----RPGNYVEPTIVTGLG 418
Query: 409 PNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHL----V 464
+ + E F P+L V + + +E N G ++IFT + R + L
Sbjct: 419 HDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKD--LGRIFRWLGPKGS 476
Query: 465 DVGQVGVNVP 474
D G V VN+P
Sbjct: 477 DCGIVNVNIP 486
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 105 bits (261), Expect = 1e-22
Identities = 97/435 (22%), Positives = 189/435 (43%), Gaps = 29/435 (6%)
Query: 43 FIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQ 102
++ GK+++ + + +P T E + QA ++ AA+ + + AF W+ + R
Sbjct: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRA 102
Query: 103 QVLLRYQQLIKENLKEIAKLITLEQGKTLADA-EGDVFRGLQVVEHACSVTSLMMGETMP 161
Q L R ++I+++ + + L +L G+ + + +GDV Q++ + +
Sbjct: 103 QHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHY----------HAIQ 152
Query: 162 SITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTF--LMKPSERVPGATM 219
+ T++ L + P+GV I P F + +W A+ G T L+ P+ P +
Sbjct: 153 ASTQEEALAGWE-PMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAP---L 208
Query: 220 LLAKLLQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKR 279
LLA+L + G G LN++ G V + P I+ ++F G+ + G + +
Sbjct: 209 LLAQLAGELGPFPGILNVLSGPASLVPILASQPGIRKVAFCGAPEEGRALRRSLAGECAE 268
Query: 280 VQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEH 339
+ +G ++ ++ A+ ++ + +V AA+ G + L V + + L E
Sbjct: 269 LGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGLRLLIQESVWDEA--MRRLQER 326
Query: 340 AKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGN-- 397
LR G D+G C+L+ +E S G ++ G
Sbjct: 327 MGRLRSGRGLDGAVDMGA-----RGAAACDLVQRFVREAQS---QGAQVFQAGDVPSERP 378
Query: 398 FVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATA 457
F PT++SN+ P C + E+ PV+V T EA+ + N P G ++++ A
Sbjct: 379 FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQA 438
Query: 458 RKYAHLVDVGQVGVN 472
+ + + VG V +N
Sbjct: 439 LELGYGLQVGTVWIN 453
Score = 68.2 bits (165), Expect = 2e-11
Identities = 62/254 (24%), Positives = 110/254 (43%), Gaps = 9/254 (3%)
Query: 35 SSVPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWA 94
S P LF+GG+F + I + + N + G V + ++ A+ + +AFP WA
Sbjct: 523 SPAPPYGLFVGGRFQAPGARSSRPIRDSSGN-LHGYVAEGGAKDIRGAVEAAHQAFPGWA 581
Query: 95 DTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRGLQVVEHACSVTSL 154
S +R +L ++ +A + QG L AE +V + + A
Sbjct: 582 GQSPGARAALLWALAAALERRKSTLASRLE-RQGAELKAAEAEVELSARRLR-AWGARVQ 639
Query: 155 MMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERV 214
G T+ + R PLGV A + P +P + + + A+ GNT +M PS
Sbjct: 640 AQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAAC 699
Query: 215 PGATMLLAKLLQDSGA--PDGTLNIIHGQHE-AVNFICDHPDIKAISFVGSNKAGEYIFE 271
P +L ++ QD P G N++ G + + H D++A+ + GS + +++
Sbjct: 700 P---LLALEVCQDMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEW 756
Query: 272 RGSRHGKRVQANMG 285
+ + K V A+ G
Sbjct: 757 ASAGNLKPVWASRG 770
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 103 bits (256), Expect = 5e-22
Identities = 103/441 (23%), Positives = 188/441 (42%), Gaps = 21/441 (4%)
Query: 77 AEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAE- 135
+++ A+ + AF + + R Q L Q+LI+E +E+ + + K +A
Sbjct: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61
Query: 136 GDVFRGLQVVEHACSVTSLMMG----ETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMI 191
+V L+ +E+ E P +D +LY + PLGV I +N+P +
Sbjct: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQD-ELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 192 PLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICDH 251
+ A+ GN+ ++KPSE LLA ++ D I G E + +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
Query: 252 PDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFG 311
D I + GS G+ I ++H V +G K+ V + + + ++ F
Sbjct: 181 FD--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238
Query: 312 AAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLI 371
+GQ C+A + + + E ++ + + D G +I+ + +RV LI
Sbjct: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLI 298
Query: 372 DSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETL 431
EG + G G ++ PTI+++V P +EEIFGPVL ++ +L
Sbjct: 299 -----EGQKVAYGGT-----GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348
Query: 432 DEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVN-VPIPVPLPMFSFTGSRSS 490
+EAIQ +N +F++N +K G V N V + + L F G +S
Sbjct: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408
Query: 491 FRGDTNFYGKQGIQFYTQLKT 511
G +++GK+ + ++ ++
Sbjct: 409 GMG--SYHGKKSFETFSHRRS 427
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 103 bits (256), Expect = 5e-22
Identities = 103/441 (23%), Positives = 188/441 (42%), Gaps = 21/441 (4%)
Query: 77 AEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAE- 135
+++ A+ + AF + + R Q L Q+LI+E +E+ + + K +A
Sbjct: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61
Query: 136 GDVFRGLQVVEHACSVTSLMMG----ETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMI 191
+V L+ +E+ E P +D +LY + PLGV I +N+P +
Sbjct: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQD-ELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 192 PLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICDH 251
+ A+ GN+ ++KPSE LLA ++ D I G E + +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
Query: 252 PDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFG 311
D I + GS G+ I ++H V +G K+ V + + + ++ F
Sbjct: 181 FD--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238
Query: 312 AAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLI 371
+GQ C+A + + + E ++ + + D G +I+ + +RV LI
Sbjct: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLI 298
Query: 372 DSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETL 431
EG + G G ++ PTI+++V P +EEIFGPVL ++ +L
Sbjct: 299 -----EGQKVAYGGT-----GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348
Query: 432 DEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVN-VPIPVPLPMFSFTGSRSS 490
+EAIQ +N +F++N +K G V N V + + L F G +S
Sbjct: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408
Query: 491 FRGDTNFYGKQGIQFYTQLKT 511
G +++GK+ + ++ ++
Sbjct: 409 GMG--SYHGKKSFETFSHRRS 427
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 103 bits (256), Expect = 5e-22
Identities = 103/441 (23%), Positives = 188/441 (42%), Gaps = 21/441 (4%)
Query: 77 AEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAE- 135
+++ A+ + AF + + R Q L Q+LI+E +E+ + + K +A
Sbjct: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61
Query: 136 GDVFRGLQVVEHACSVTSLMMG----ETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMI 191
+V L+ +E+ E P +D +LY + PLGV I +N+P +
Sbjct: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQD-ELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 192 PLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICDH 251
+ A+ GN+ ++KPSE LLA ++ D I G E + +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
Query: 252 PDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFG 311
D I + GS G+ I ++H V +G K+ V + + + ++ F
Sbjct: 181 FD--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238
Query: 312 AAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLI 371
+GQ C+A + + + E ++ + + D G +I+ + +RV LI
Sbjct: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLI 298
Query: 372 DSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETL 431
EG + G G ++ PTI+++V P +EEIFGPVL ++ +L
Sbjct: 299 -----EGQKVAYGGT-----GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348
Query: 432 DEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVN-VPIPVPLPMFSFTGSRSS 490
+EAIQ +N +F++N +K G V N V + + L F G +S
Sbjct: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408
Query: 491 FRGDTNFYGKQGIQFYTQLKT 511
G +++GK+ + ++ ++
Sbjct: 409 GMG--SYHGKKSFETFSHRRS 427
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 94.4 bits (233), Expect = 2e-19
Identities = 67/304 (22%), Positives = 135/304 (44%), Gaps = 12/304 (3%)
Query: 169 LYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDS 228
++ ++ P G+ IAP+N+P + L + A+ G+ ++KPSE G +LA++L
Sbjct: 17 VFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY 76
Query: 229 GAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKN 288
++ G + + +H + I F GS + G+ + ++H V +G KN
Sbjct: 77 -LDQSCFAVVLGGPQETGQLLEHK-LDYIFFTGSPRVGKIVMTAATKHLTPVTLELGGKN 134
Query: 289 HGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAG 348
V + + + N++ + AGQ C+A + E ++ L ++
Sbjct: 135 PCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDD 194
Query: 349 DQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVK 408
Q +LG +I + +R+ L+ G + + G+ E+ ++ PT++ +V+
Sbjct: 195 PQSSPNLGRIINQKQFQRLRALLGCGR-----VAIGGQS-----NESDRYIAPTVLVDVQ 244
Query: 409 PNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQ 468
+EEIFGP+L ++ +++DEAI+ +N F+ + + G
Sbjct: 245 ETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGS 304
Query: 469 VGVN 472
G N
Sbjct: 305 FGGN 308
>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 94.4 bits (233), Expect = 2e-19
Identities = 67/304 (22%), Positives = 135/304 (44%), Gaps = 12/304 (3%)
Query: 169 LYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDS 228
++ ++ P G+ IAP+N+P + L + A+ G+ ++KPSE G +LA++L
Sbjct: 17 VFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY 76
Query: 229 GAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKN 288
++ G + + +H + I F GS + G+ + ++H V +G KN
Sbjct: 77 -LDQSCFAVVLGGPQETGQLLEHK-LDYIFFTGSPRVGKIVMTAATKHLTPVTLELGGKN 134
Query: 289 HGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAG 348
V + + + N++ + AGQ C+A + E ++ L ++
Sbjct: 135 PCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDD 194
Query: 349 DQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVK 408
Q +LG +I + +R+ L+ G + + G+ E+ ++ PT++ +V+
Sbjct: 195 PQSSPNLGRIINQKQFQRLRALLGCGR-----VAIGGQS-----NESDRYIAPTVLVDVQ 244
Query: 409 PNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQ 468
+EEIFGP+L ++ +++DEAI+ +N F+ + + G
Sbjct: 245 ETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGS 304
Query: 469 VGVN 472
G N
Sbjct: 305 FGGN 308
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 93.6 bits (231), Expect = 4e-19
Identities = 101/455 (22%), Positives = 185/455 (40%), Gaps = 32/455 (7%)
Query: 79 MDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDV 138
M+ + ++AF + + R Q L +++++E K+I I + L +E +V
Sbjct: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAAD----LCKSEFNV 56
Query: 139 FRGLQVV---EHACSVTSLMMGETMPSITKDM-----DLYSYRLPLGVCAGIAPFNFPAM 190
+ + E + +L T + K++ + Y PLGV I +N+P +
Sbjct: 57 YSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFV 116
Query: 191 IPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICD 250
+ + A+ GN ++KPSE +LAKLL D + I G E +
Sbjct: 117 LTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQ 176
Query: 251 HPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAF 310
D I + G+ G+ + E ++H V +G K+ + D + + ++ +
Sbjct: 177 RFD--HIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKY 234
Query: 311 GAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNL 370
GQ C+A + + + ++ + D +I + +R+ +L
Sbjct: 235 MNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSL 294
Query: 371 IDSGTKEGASILLDGRKIKVKGY--ENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLET 428
L+G+KI G E ++ PT++++V P +EEIFGP+L ++
Sbjct: 295 ------------LEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPV 342
Query: 429 ETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQV-GVNVPIPVPLPMFSFTGS 487
+ +DEAI +N +F+ N ++ G V G +V + L F F G
Sbjct: 343 KNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGV 402
Query: 488 RSSFRGDTNFYGKQGIQ-FYTQLKTITSQWKEEDA 521
SS G ++GK F Q + K E A
Sbjct: 403 GSSGMG--AYHGKHSFDTFSHQRPCLLKSLKREGA 435
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 93.6 bits (231), Expect = 4e-19
Identities = 101/455 (22%), Positives = 185/455 (40%), Gaps = 32/455 (7%)
Query: 79 MDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDV 138
M+ + ++AF + + R Q L +++++E K+I I + L +E +V
Sbjct: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAAD----LCKSEFNV 56
Query: 139 FRGLQVV---EHACSVTSLMMGETMPSITKDM-----DLYSYRLPLGVCAGIAPFNFPAM 190
+ + E + +L T + K++ + Y PLGV I +N+P +
Sbjct: 57 YSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFV 116
Query: 191 IPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICD 250
+ + A+ GN ++KPSE +LAKLL D + I G E +
Sbjct: 117 LTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQ 176
Query: 251 HPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAF 310
D I + G+ G+ + E ++H V +G K+ + D + + ++ +
Sbjct: 177 RFD--HIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKY 234
Query: 311 GAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNL 370
GQ C+A + + + ++ + D +I + +R+ +L
Sbjct: 235 MNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSL 294
Query: 371 IDSGTKEGASILLDGRKIKVKGY--ENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLET 428
L+G+KI G E ++ PT++++V P +EEIFGP+L ++
Sbjct: 295 ------------LEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPV 342
Query: 429 ETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQV-GVNVPIPVPLPMFSFTGS 487
+ +DEAI +N +F+ N ++ G V G +V + L F F G
Sbjct: 343 KNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGV 402
Query: 488 RSSFRGDTNFYGKQGIQ-FYTQLKTITSQWKEEDA 521
SS G ++GK F Q + K E A
Sbjct: 403 GSSGMG--AYHGKHSFDTFSHQRPCLLKSLKREGA 435
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 89.4 bits (220), Expect = 8e-18
Identities = 64/265 (24%), Positives = 121/265 (45%), Gaps = 12/265 (4%)
Query: 175 PLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGT 234
P G+ IAP+N+P + L A+ GN ++KPSE +LA++L
Sbjct: 104 PFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSC 162
Query: 235 LNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMP 294
++ G + + +H I F GS + G+ + ++H V +G KN V
Sbjct: 163 FAVVLGGPQETGQLLEHR-FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDD 221
Query: 295 DANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGAD 354
+ + + N++ + AGQ C+A + E ++ L ++ Q +
Sbjct: 222 NCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPN 281
Query: 355 LGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCY 414
LG +I + +R+ L+ G + + G+ E+ ++ PT++ +V+
Sbjct: 282 LGRIINQKQFQRLRALLGCGR-----VAIGGQSD-----ESDRYIAPTVLVDVQEMEPVM 331
Query: 415 KEEIFGPVLVVLETETLDEAIQIVN 439
+EEIFGP+L ++ ++LDEAI+ +N
Sbjct: 332 QEEIFGPILPIVNVQSLDEAIEFIN 356
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 89.4 bits (220), Expect = 8e-18
Identities = 64/265 (24%), Positives = 121/265 (45%), Gaps = 12/265 (4%)
Query: 175 PLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGT 234
P G+ IAP+N+P + L A+ GN ++KPSE +LA++L
Sbjct: 67 PFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSC 125
Query: 235 LNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMP 294
++ G + + +H I F GS + G+ + ++H V +G KN V
Sbjct: 126 FAVVLGGPQETGQLLEHR-FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDD 184
Query: 295 DANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGAD 354
+ + + N++ + AGQ C+A + E ++ L ++ Q +
Sbjct: 185 NCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPN 244
Query: 355 LGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCY 414
LG +I + +R+ L+ G + + G+ E+ ++ PT++ +V+
Sbjct: 245 LGRIINQKQFQRLRALLGCGR-----VAIGGQSD-----ESDRYIAPTVLVDVQEMEPVM 294
Query: 415 KEEIFGPVLVVLETETLDEAIQIVN 439
+EEIFGP+L ++ ++LDEAI+ +N
Sbjct: 295 QEEIFGPILPIVNVQSLDEAIEFIN 319
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 89.4 bits (220), Expect = 8e-18
Identities = 64/265 (24%), Positives = 121/265 (45%), Gaps = 12/265 (4%)
Query: 175 PLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGT 234
P G+ IAP+N+P + L A+ GN ++KPSE +LA++L
Sbjct: 104 PFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSC 162
Query: 235 LNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMP 294
++ G + + +H I F GS + G+ + ++H V +G KN V
Sbjct: 163 FAVVLGGPQETGQLLEHR-FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDD 221
Query: 295 DANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGAD 354
+ + + N++ + AGQ C+A + E ++ L ++ Q +
Sbjct: 222 NCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPN 281
Query: 355 LGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCY 414
LG +I + +R+ L+ G + + G+ E+ ++ PT++ +V+
Sbjct: 282 LGRIINQKQFQRLRALLGCGR-----VAIGGQSD-----ESDRYIAPTVLVDVQEMEPVM 331
Query: 415 KEEIFGPVLVVLETETLDEAIQIVN 439
+EEIFGP+L ++ ++LDEAI+ +N
Sbjct: 332 QEEIFGPILPIVNVQSLDEAIEFIN 356
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 84.0 bits (206), Expect = 3e-16
Identities = 97/396 (24%), Positives = 169/396 (42%), Gaps = 26/396 (6%)
Query: 74 ATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLK-EIAKLITLEQGKTLA 132
A K+ ++ AI + A W + R Q+ L+ ++ + EI + QGKT+
Sbjct: 97 ADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVI 156
Query: 133 DAEGDVFRGL-QVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMI 191
AE D L + G+ S+ + YR G A I+PFNF A+
Sbjct: 157 QAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIG 216
Query: 192 PLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAV-NFICD 250
A++ GN L KPS+ A+ + ++L+++G P + + + +
Sbjct: 217 GNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTS 275
Query: 251 HPDIKAISFVGSNKAGEYIFERGSRH------GKRVQANMGAKNHGVVMPDANKENTLNQ 304
+ I+F GS ++++++ +++ R+ G KN V A+ E+ ++
Sbjct: 276 SEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSG 335
Query: 305 LVGAAFGAAGQRCMALSTAVLVGEAKKWLPE--LVEHAKNLRVNAGDQPGADLGP----L 358
+ +AF GQ+C A S + + L EH+ R+ GD P D G +
Sbjct: 336 TLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS---RIKVGD-PAEDFGTFFSAV 391
Query: 359 ITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEI 418
I ++ R+ ++ + +L G K G FV P I+ + P KEEI
Sbjct: 392 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSV---GYFVEPCIVESKDPQEPIMKEEI 448
Query: 419 FGPVL--VVLETETLDEAIQIVNN-NPYGNGTAIFT 451
FGPVL V + E +Q+V++ YG A+F+
Sbjct: 449 FGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFS 484
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 84.0 bits (206), Expect = 3e-16
Identities = 97/396 (24%), Positives = 169/396 (42%), Gaps = 26/396 (6%)
Query: 74 ATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLK-EIAKLITLEQGKTLA 132
A K+ ++ AI + A W + R Q+ L+ ++ + EI + QGKT+
Sbjct: 37 ADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVI 96
Query: 133 DAEGDVFRGL-QVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMI 191
AE D L + G+ S+ + YR G A I+PFNF A+
Sbjct: 97 QAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIG 156
Query: 192 PLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAV-NFICD 250
A++ GN L KPS+ A+ + ++L+++G P + + + +
Sbjct: 157 GNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTS 215
Query: 251 HPDIKAISFVGSNKAGEYIFERGSRH------GKRVQANMGAKNHGVVMPDANKENTLNQ 304
+ I+F GS ++++++ +++ R+ G KN V A+ E+ ++
Sbjct: 216 SEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSG 275
Query: 305 LVGAAFGAAGQRCMALSTAVLVGEAKKWLPE--LVEHAKNLRVNAGDQPGADLGP----L 358
+ +AF GQ+C A S + + L EH+ R+ GD P D G +
Sbjct: 276 TLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS---RIKVGD-PAEDFGTFFSAV 331
Query: 359 ITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEI 418
I ++ R+ ++ + +L G K G FV P I+ + P KEEI
Sbjct: 332 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSV---GYFVEPCIVESKDPQEPIMKEEI 388
Query: 419 FGPVL--VVLETETLDEAIQIVNN-NPYGNGTAIFT 451
FGPVL V + E +Q+V++ YG A+F+
Sbjct: 389 FGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFS 424
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 84.0 bits (206), Expect = 3e-16
Identities = 97/396 (24%), Positives = 169/396 (42%), Gaps = 26/396 (6%)
Query: 74 ATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLK-EIAKLITLEQGKTLA 132
A K+ ++ AI + A W + R Q+ L+ ++ + EI + QGKT+
Sbjct: 97 ADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVI 156
Query: 133 DAEGDVFRGL-QVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMI 191
AE D L + G+ S+ + YR G A I+PFNF A+
Sbjct: 157 QAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIG 216
Query: 192 PLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAV-NFICD 250
A++ GN L KPS+ A+ + ++L+++G P + + + +
Sbjct: 217 GNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTS 275
Query: 251 HPDIKAISFVGSNKAGEYIFERGSRH------GKRVQANMGAKNHGVVMPDANKENTLNQ 304
+ I+F GS ++++++ +++ R+ G KN V A+ E+ ++
Sbjct: 276 SEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSG 335
Query: 305 LVGAAFGAAGQRCMALSTAVLVGEAKKWLPE--LVEHAKNLRVNAGDQPGADLGP----L 358
+ +AF GQ+C A S + + L EH+ R+ GD P D G +
Sbjct: 336 TLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS---RIKVGD-PAEDFGTFFSAV 391
Query: 359 ITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEI 418
I ++ R+ ++ + +L G K G FV P I+ + P KEEI
Sbjct: 392 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSV---GYFVEPCIVESKDPQEPIMKEEI 448
Query: 419 FGPVL--VVLETETLDEAIQIVNN-NPYGNGTAIFT 451
FGPVL V + E +Q+V++ YG A+F+
Sbjct: 449 FGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFS 484
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,443,801
Number of Sequences: 37866
Number of extensions: 848699
Number of successful extensions: 2078
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1931
Number of HSP's gapped (non-prelim): 45
length of query: 535
length of database: 18,247,518
effective HSP length: 107
effective length of query: 428
effective length of database: 14,195,856
effective search space: 6075826368
effective search space used: 6075826368
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.