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Search of human proteins with 16876435
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16876435 G protein-coupled receptor 101 [Homo sapiens]
(508 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16876435 G protein-coupled receptor 101 [Homo sapiens] 1023 0.0
gi|24476016 G protein-coupled receptor 161 isoform 2 [Homo sapiens] 129 8e-30
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 120 4e-27
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 114 2e-25
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 114 2e-25
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 114 2e-25
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 114 2e-25
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 103 3e-22
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 100 2e-21
gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens] 100 5e-21
gi|4503383 dopamine receptor D1 [Homo sapiens] 97 3e-20
gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens] 97 3e-20
gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens] 97 3e-20
gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens] 97 3e-20
gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens] 97 3e-20
gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens] 97 3e-20
gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens] 97 3e-20
gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens] 97 3e-20
gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens] 97 3e-20
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 96 8e-20
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 96 8e-20
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 96 8e-20
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens] 95 1e-19
gi|4503385 dopamine receptor D2 isoform long [Homo sapiens] 94 2e-19
gi|15150803 opsin 4 isoform 1 [Homo sapiens] 92 1e-18
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 91 3e-18
gi|5730019 peropsin [Homo sapiens] 91 3e-18
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 90 4e-18
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 89 7e-18
gi|31083315 G protein-coupled receptor 45 [Homo sapiens] 89 9e-18
>gi|16876435 G protein-coupled receptor 101 [Homo sapiens]
Length = 508
Score = 1023 bits (2644), Expect = 0.0
Identities = 508/508 (100%), Positives = 508/508 (100%)
Query: 1 MTSTCTNSTRESNSSHTCMPLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKP 60
MTSTCTNSTRESNSSHTCMPLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKP
Sbjct: 1 MTSTCTNSTRESNSSHTCMPLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKP 60
Query: 61 QLLQVTNRFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVN 120
QLLQVTNRFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVN
Sbjct: 61 QLLQVTNRFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVN 120
Query: 121 TIVVVSVDRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGWGQAAFDERNA 180
TIVVVSVDRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGWGQAAFDERNA
Sbjct: 121 TIVVVSVDRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGWGQAAFDERNA 180
Query: 181 LCSMIWGASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQHALLYNVKRHSLEVRVKD 240
LCSMIWGASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQHALLYNVKRHSLEVRVKD
Sbjct: 181 LCSMIWGASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQHALLYNVKRHSLEVRVKD 240
Query: 241 CVENEDEEGAEKKEEFQDESEFRRQHEGEVKAKEGRMEAKDGSLKAKEGSTGTSESSVEA 300
CVENEDEEGAEKKEEFQDESEFRRQHEGEVKAKEGRMEAKDGSLKAKEGSTGTSESSVEA
Sbjct: 241 CVENEDEEGAEKKEEFQDESEFRRQHEGEVKAKEGRMEAKDGSLKAKEGSTGTSESSVEA 300
Query: 301 RGSEEVRESSTVASDGSMEGKEGSTKVEENSMKADKGRTEVNQCSIDLGEDDMEFGEDDI 360
RGSEEVRESSTVASDGSMEGKEGSTKVEENSMKADKGRTEVNQCSIDLGEDDMEFGEDDI
Sbjct: 301 RGSEEVRESSTVASDGSMEGKEGSTKVEENSMKADKGRTEVNQCSIDLGEDDMEFGEDDI 360
Query: 361 NFSEDDVEAVNIPESLPPSRRNSNSNPPLPRCYQCKAAKVIFIIIFSYVLSLGPYCFLAV 420
NFSEDDVEAVNIPESLPPSRRNSNSNPPLPRCYQCKAAKVIFIIIFSYVLSLGPYCFLAV
Sbjct: 361 NFSEDDVEAVNIPESLPPSRRNSNSNPPLPRCYQCKAAKVIFIIIFSYVLSLGPYCFLAV 420
Query: 421 LAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYGYMHKTIKKEIQDMLKKFFCKEKPPK 480
LAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYGYMHKTIKKEIQDMLKKFFCKEKPPK
Sbjct: 421 LAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYGYMHKTIKKEIQDMLKKFFCKEKPPK 480
Query: 481 EDSHPDLPGTEGGTEGKIVPSYDSATFP 508
EDSHPDLPGTEGGTEGKIVPSYDSATFP
Sbjct: 481 EDSHPDLPGTEGGTEGKIVPSYDSATFP 508
>gi|24476016 G protein-coupled receptor 161 isoform 2 [Homo sapiens]
Length = 529
Score = 129 bits (323), Expect = 8e-30
Identities = 63/192 (32%), Positives = 107/192 (55%), Gaps = 2/192 (1%)
Query: 31 GIIRSTVLVIFLAASFV--GNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWV 88
G+I + + I + FV GN+V+ + L +K LL ++N+F+F+L +++ L LV P+V
Sbjct: 25 GVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFV 84
Query: 89 VATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKMTQRRG 148
V +S+ W +C L L + AS+ T+ V+++DRY ++++P+ YP K+T R
Sbjct: 85 VTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRA 144
Query: 149 YLLLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIWGASPSYTILSVVSFIVIPLIVM 208
+ L W+ +++ PPL+GW FDE +C W P YT + + P +VM
Sbjct: 145 VMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVM 204
Query: 209 IACYSVVFCAAR 220
+ CY +F AR
Sbjct: 205 LVCYGFIFRVAR 216
Score = 48.1 bits (113), Expect = 2e-05
Identities = 25/76 (32%), Positives = 43/76 (56%), Gaps = 3/76 (3%)
Query: 394 QCKAAKVIFIIIFSYVLSLGPYCF-LAVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPY 452
QCKA I +++ +++++ GPY +A A+W ++ V + T WL F HP
Sbjct: 265 QCKALITILVVLGAFMVTWGPYMVVIASEALWG--KSSVSPSLETWATWLSFASAVCHPL 322
Query: 453 VYGYMHKTIKKEIQDM 468
+YG +KT++KE+ M
Sbjct: 323 IYGLWNKTVRKELLGM 338
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 120 bits (300), Expect = 4e-27
Identities = 101/455 (22%), Positives = 190/455 (41%), Gaps = 67/455 (14%)
Query: 26 ISLAHGIIRSTVLVIFLAASFVGN--IVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISL 83
+++++ +I S +L + + +GN +V A+ L+R Q V N I +L VTDL+ L
Sbjct: 31 VTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQ--NVANYLIGSLAVTDLMVSVL 88
Query: 84 VAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKM 143
V P V W L C ++L L +S+ + +++DRY +I P+ Y +K
Sbjct: 89 VLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKR 148
Query: 144 TQRRGYLLLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIWGASPSYTILSVVSFIVI 203
T RR L+ TW++ L S PP+ GW ++R+ + YTI S I
Sbjct: 149 TPRRAAALISLTWLIGFLISIPPMLGWRTP--EDRSDPDACTISKDHGYTIYSTFGAFYI 206
Query: 204 PLIVMIACYSVVFCAARRQHALLYNVKRHSLEVRVKDCVENEDEEGAEKKEEFQDESEFR 263
PL++M+ Y +F AAR R++ V+ ++ GA+ + + +
Sbjct: 207 PLLLMLVLYGRIFRAAR---------------FRIRKTVKKVEKTGADTRHGASPAPQPK 251
Query: 264 RQHEGEVKAKEGRM--EAKDGSLKAKEGSTGTSESSVEARGSEEVRESSTVASDGSMEGK 321
+ GE ++ R+ E+K G G+ VR+ A+ +E
Sbjct: 252 KSVNGESGSRNWRLGVESKAGGALCANGA---------------VRQGDDGAALEVIEVH 296
Query: 322 EGSTKVEENSMKADKGRTEVNQCSIDLGEDDMEFGEDDINFSEDDVEAVNIPESLPPSRR 381
E + ++ G T S + + R
Sbjct: 297 RVGNSKEHLPLPSEAGPTPCAPASFE-----------------------------RKNER 327
Query: 382 NSNSNPPLPRCYQCKAAKVIFIIIFSYVLSLGPYCFLAVLAVWVDVETQVPQWVITIIIW 441
N+ + + + K K + II+ +++L P+ +A++ + + +P + II W
Sbjct: 328 NAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINW 387
Query: 442 LFFLQCCIHPYVYGYMHKTIKKEIQDMLKKFFCKE 476
L + ++P +Y Y +K + + ++K FC++
Sbjct: 388 LGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ 422
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 114 bits (286), Expect = 2e-25
Identities = 65/215 (30%), Positives = 112/215 (52%), Gaps = 5/215 (2%)
Query: 8 STRESNSSHTCMPLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVTN 67
S S+SS+ P + P++++ I+ +L + +GNI++ L + L VT+
Sbjct: 5 SGNASDSSNCTQPPA--PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTH 62
Query: 68 RFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSV 127
+I NL V DLL S V P+ V +W FC ++ L AS+ + ++S+
Sbjct: 63 YYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
Query: 128 DRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIWG 187
DRY+ + +PL YP+ +TQRRG + L W ++++ S PL+GW Q A E +C +
Sbjct: 123 DRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPA-PEDETICQI--N 179
Query: 188 ASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQ 222
P Y + S + +PL +++ Y V+ A+R+
Sbjct: 180 EEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRE 214
Score = 42.7 bits (99), Expect = 8e-04
Identities = 27/102 (26%), Positives = 50/102 (49%), Gaps = 6/102 (5%)
Query: 396 KAAKVIFIIIFSYVLSLGPYCFLAVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYG 455
KAAK + I++ +VL P+ + + + + + + V I+ WL +L CI+P +Y
Sbjct: 269 KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP-DFKPSETVFKIVFWLGYLNSCINPIIYP 327
Query: 456 YMHKTIKKEIQDMLK-KFFCKEKPPKE----DSHPDLPGTEG 492
+ KK Q++L+ + C+++ K HP EG
Sbjct: 328 CSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEG 369
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 114 bits (286), Expect = 2e-25
Identities = 65/215 (30%), Positives = 112/215 (52%), Gaps = 5/215 (2%)
Query: 8 STRESNSSHTCMPLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVTN 67
S S+SS+ P + P++++ I+ +L + +GNI++ L + L VT+
Sbjct: 5 SGNASDSSNCTQPPA--PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTH 62
Query: 68 RFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSV 127
+I NL V DLL S V P+ V +W FC ++ L AS+ + ++S+
Sbjct: 63 YYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
Query: 128 DRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIWG 187
DRY+ + +PL YP+ +TQRRG + L W ++++ S PL+GW Q A E +C +
Sbjct: 123 DRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPA-PEDETICQI--N 179
Query: 188 ASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQ 222
P Y + S + +PL +++ Y V+ A+R+
Sbjct: 180 EEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRE 214
Score = 42.7 bits (99), Expect = 8e-04
Identities = 27/102 (26%), Positives = 50/102 (49%), Gaps = 6/102 (5%)
Query: 396 KAAKVIFIIIFSYVLSLGPYCFLAVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYG 455
KAAK + I++ +VL P+ + + + + + + V I+ WL +L CI+P +Y
Sbjct: 269 KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP-DFKPSETVFKIVFWLGYLNSCINPIIYP 327
Query: 456 YMHKTIKKEIQDMLK-KFFCKEKPPKE----DSHPDLPGTEG 492
+ KK Q++L+ + C+++ K HP EG
Sbjct: 328 CSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEG 369
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 114 bits (286), Expect = 2e-25
Identities = 65/215 (30%), Positives = 112/215 (52%), Gaps = 5/215 (2%)
Query: 8 STRESNSSHTCMPLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVTN 67
S S+SS+ P + P++++ I+ +L + +GNI++ L + L VT+
Sbjct: 5 SGNASDSSNCTQPPA--PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTH 62
Query: 68 RFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSV 127
+I NL V DLL S V P+ V +W FC ++ L AS+ + ++S+
Sbjct: 63 YYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
Query: 128 DRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIWG 187
DRY+ + +PL YP+ +TQRRG + L W ++++ S PL+GW Q A E +C +
Sbjct: 123 DRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPA-PEDETICQI--N 179
Query: 188 ASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQ 222
P Y + S + +PL +++ Y V+ A+R+
Sbjct: 180 EEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRE 214
Score = 42.7 bits (99), Expect = 8e-04
Identities = 27/102 (26%), Positives = 50/102 (49%), Gaps = 6/102 (5%)
Query: 396 KAAKVIFIIIFSYVLSLGPYCFLAVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYG 455
KAAK + I++ +VL P+ + + + + + + V I+ WL +L CI+P +Y
Sbjct: 269 KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP-DFKPSETVFKIVFWLGYLNSCINPIIYP 327
Query: 456 YMHKTIKKEIQDMLK-KFFCKEKPPKE----DSHPDLPGTEG 492
+ KK Q++L+ + C+++ K HP EG
Sbjct: 328 CSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEG 369
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 114 bits (286), Expect = 2e-25
Identities = 65/215 (30%), Positives = 112/215 (52%), Gaps = 5/215 (2%)
Query: 8 STRESNSSHTCMPLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVTN 67
S S+SS+ P + P++++ I+ +L + +GNI++ L + L VT+
Sbjct: 5 SGNASDSSNCTQPPA--PVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTH 62
Query: 68 RFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSV 127
+I NL V DLL S V P+ V +W FC ++ L AS+ + ++S+
Sbjct: 63 YYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISI 122
Query: 128 DRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIWG 187
DRY+ + +PL YP+ +TQRRG + L W ++++ S PL+GW Q A E +C +
Sbjct: 123 DRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPA-PEDETICQI--N 179
Query: 188 ASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQ 222
P Y + S + +PL +++ Y V+ A+R+
Sbjct: 180 EEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRE 214
Score = 42.7 bits (99), Expect = 8e-04
Identities = 27/102 (26%), Positives = 50/102 (49%), Gaps = 6/102 (5%)
Query: 396 KAAKVIFIIIFSYVLSLGPYCFLAVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYG 455
KAAK + I++ +VL P+ + + + + + + V I+ WL +L CI+P +Y
Sbjct: 269 KAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP-DFKPSETVFKIVFWLGYLNSCINPIIYP 327
Query: 456 YMHKTIKKEIQDMLK-KFFCKEKPPKE----DSHPDLPGTEG 492
+ KK Q++L+ + C+++ K HP EG
Sbjct: 328 CSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEG 369
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 103 bits (258), Expect = 3e-22
Identities = 64/193 (33%), Positives = 96/193 (49%), Gaps = 5/193 (2%)
Query: 29 AHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWV 88
A G+ L F+ + GN+++ L + L VTN FI NL V DLL + V P+
Sbjct: 94 AQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFS 153
Query: 89 VATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKMTQRRG 148
V FW FC ++ L AS+ ++ +SVDRY+ + H L YP+ MT+R+
Sbjct: 154 ATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKA 213
Query: 149 YLLLYGTWIVAILQSTPPLYGWGQ-AAFDERNALCSMIWGASPSYTILSVVSFIVIPLIV 207
+L W+VA++ S PL GW + DER C + A Y + S V +P+ V
Sbjct: 214 AAILALLWVVALVVSVGPLLGWKEPVPPDER--FCGITEEA--GYAVFSSVCSFYLPMAV 269
Query: 208 MIACYSVVFCAAR 220
++ Y V+ AR
Sbjct: 270 IVVMYCRVYVVAR 282
Score = 36.6 bits (83), Expect = 0.055
Identities = 19/75 (25%), Positives = 37/75 (49%), Gaps = 1/75 (1%)
Query: 396 KAAKVIFIIIFSYVLSLGPYCFLAVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYG 455
KAAK + I++ +VL P+ F+ L + + + V +I WL + C++P +Y
Sbjct: 345 KAAKTLAIVVGVFVLCWFPFFFVLPLGSLFP-QLKPSEGVFKVIFWLGYFNSCVNPLIYP 403
Query: 456 YMHKTIKKEIQDMLK 470
+ K+ +L+
Sbjct: 404 CSSREFKRAFLRLLR 418
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 100 bits (250), Expect = 2e-21
Identities = 63/208 (30%), Positives = 108/208 (51%), Gaps = 7/208 (3%)
Query: 14 SSHTCMPLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVTNRFIFNL 73
SS++ +P + +++ G+ VL F+ + VGNI++ L + L TN FI NL
Sbjct: 32 SSNSTLPQLDITRAISVGL----VLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNL 87
Query: 74 LVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSI 133
+ DLL V P+ A V +W L FC ++ L AS+ ++ +S+DRY+ +
Sbjct: 88 AMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGV 147
Query: 134 IHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIWGASPSYT 193
+ L YP+ +T+R+ L L W+++ + S PL GW + A ++ + C + P Y
Sbjct: 148 RYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPND-DKECGVT--EEPFYA 204
Query: 194 ILSVVSFIVIPLIVMIACYSVVFCAARR 221
+ S + IPL V++ Y V+ A+R
Sbjct: 205 LFSSLGSFYIPLAVILVMYCRVYIVAKR 232
Score = 35.8 bits (81), Expect = 0.095
Identities = 25/103 (24%), Positives = 47/103 (45%), Gaps = 4/103 (3%)
Query: 361 NFSEDDVEAVNIPESLPPSRRNSNSNPPLPRCYQCKAAKVIFIIIFSYVLSLGPYCFLAV 420
NF ED + + P R+S + + KAAK + I++ ++L P+ F+A+
Sbjct: 259 NFHEDTLSSTKAKGHNP---RSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPF-FIAL 314
Query: 421 LAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYGYMHKTIKK 463
+ + P V ++ WL + C++P +Y K K+
Sbjct: 315 PLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKR 357
>gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]
Length = 479
Score = 99.8 bits (247), Expect = 5e-21
Identities = 93/464 (20%), Positives = 198/464 (42%), Gaps = 54/464 (11%)
Query: 36 TVLVIFLAA--------SFVGNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPW 87
TV ++F+A + VGNI++ L ++ QL V N F+F+L DL+ +
Sbjct: 29 TVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNL 88
Query: 88 VVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKMTQRR 147
+ +WPL + C ++L ++ + ASV ++++S DRY + PL+YP++ T +
Sbjct: 89 YTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKM 148
Query: 148 GYLLLYGTWIVAILQSTPPLYGWGQAAFDERNA---LCSMIWGASPSYTILSVVSFIVIP 204
L++ W+++ + P + W Q +R C + + ++P+ T + ++ +P
Sbjct: 149 AGLMIAAAWVLSFVLWAPAILFW-QFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLP 207
Query: 205 LIVMIACYSVVFCAARRQHALLYNVKRHSLEVRVKDCVENEDEEGAEKKEEFQDESEFRR 264
+++M Y + A+R + V +H E +E K F ++
Sbjct: 208 VVIMTVLYIHISLASRSR------VHKHRPE---------GPKEKKAKTLAFLKSPLMKQ 252
Query: 265 QHEGEVKAKEGRMEAKDGSLK-------------------AKEGSTGTSESSVEARGSEE 305
+ + R E ++G L+ + E S+G++ + + R + E
Sbjct: 253 SVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATE 312
Query: 306 VRESSTVASDGSMEGKEGSTKVEENSMKADKGRTEVNQCSIDLGEDDMEFGEDDINFSED 365
+ S+T A+ +M + ++ ++ +++ + G + + E
Sbjct: 313 L--STTEATTPAMP----APPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAG 366
Query: 366 DVEAVNIPESLPPSRRNSNSNPPLPRCYQCKAAKVIFIIIFSYVLSLGPYCFLAVLAVWV 425
A N+ RN + K + IF I+ +++L+ PY + ++ +
Sbjct: 367 MRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTF- 425
Query: 426 DVETQVPQWVITIIIWLFFLQCCIHPYVYGYMHKTIKKEIQDML 469
++ +P V +I WL ++ I+P Y + T KK + +L
Sbjct: 426 -CQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLL 468
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 97.4 bits (241), Expect = 3e-20
Identities = 74/252 (29%), Positives = 124/252 (49%), Gaps = 18/252 (7%)
Query: 32 IIRSTVLVIFLAASFVGN-IVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWVVA 90
I+ + L + + ++ +GN +V A V++ + +VTN F+ +L V+DLL LV PW
Sbjct: 24 ILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAV 83
Query: 91 TSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKMTQRRGYL 150
+ FWP S FC V+ + + AS+ + V+SVDRY +I P Y KMT + ++
Sbjct: 84 AEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFI 142
Query: 151 LLYGTWIVAILQSTPPL-YGWGQA---------AFDERNALCSMIWGASPSYTILSVVSF 200
L+ W +++L S P+ W +A A + + S +Y I S V
Sbjct: 143 LISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVIS 202
Query: 201 IVIPLIVMIACYSVVFCAARRQHALLYNVKRHSLEVRVKDCVENEDEEGAEKKEE-FQDE 259
IP+ +MI Y+ ++ A++Q + ++R + V K+C + G K E Q E
Sbjct: 203 FYIPVAIMIVTYTRIYRIAQKQIRRIAALERAA--VHAKNC---QTTTGNGKPVECSQPE 257
Query: 260 SEFRRQHEGEVK 271
S F+ + E K
Sbjct: 258 SSFKMSFKRETK 269
>gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 97.1 bits (240), Expect = 3e-20
Identities = 93/471 (19%), Positives = 198/471 (42%), Gaps = 26/471 (5%)
Query: 7 NSTRESNSSHTCM-PLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQV 65
NST SN+S P + + S LV + +GNI++ + ++ L V
Sbjct: 3 NSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLV-----TIIGNILVMVSIKVNRHLQTV 57
Query: 66 TNRFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVV 125
N F+F+L DL+ +V +WPL C ++L ++ + ASV ++++
Sbjct: 58 NNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLII 117
Query: 126 SVDRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGW----GQAAFDERNAL 181
S DRY + PL+YP K T + +++ W+++ + P + W G ++
Sbjct: 118 SFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGE-- 175
Query: 182 CSMIWGASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQHALLYNVKRHSLE-VRVKD 240
C + + ++ + T + ++ +P+I+M Y + A++ + +K+ E V +D
Sbjct: 176 CYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSR------IKKDKKEPVANQD 229
Query: 241 CVENEDEEG--AEKKEEFQDESEFRRQHEGEVKAKEGRMEAKDGSLKAKEGSTGTSESSV 298
V +G + S+ +H K R + ++ +E + +SV
Sbjct: 230 PVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSV 289
Query: 299 EARGSEEVRESSTVASDGSMEGKEGSTKVEENSMKADKGRTEVNQCSIDLGEDDMEFGED 358
A S +R+ + ++ G +K E + + T+ + +
Sbjct: 290 SAVAS-NMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVG 348
Query: 359 DINFSEDDVEAVNIPESLPPSRRNSNSNPPLPRCYQCKAAKVIFIIIFSYVLSLGPYCFL 418
+ D+ + + + + +++ + PP R + K + I I+ +++++ PY +
Sbjct: 349 SSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSR--EKKVTRTILAILLAFIITWAPYNVM 406
Query: 419 AVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYGYMHKTIKKEIQDML 469
++ + +P V TI WL ++ I+P Y + T KK + +L
Sbjct: 407 VLINTF--CAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 97.1 bits (240), Expect = 3e-20
Identities = 93/471 (19%), Positives = 198/471 (42%), Gaps = 26/471 (5%)
Query: 7 NSTRESNSSHTCM-PLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQV 65
NST SN+S P + + S LV + +GNI++ + ++ L V
Sbjct: 3 NSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLV-----TIIGNILVMVSIKVNRHLQTV 57
Query: 66 TNRFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVV 125
N F+F+L DL+ +V +WPL C ++L ++ + ASV ++++
Sbjct: 58 NNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLII 117
Query: 126 SVDRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGW----GQAAFDERNAL 181
S DRY + PL+YP K T + +++ W+++ + P + W G ++
Sbjct: 118 SFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGE-- 175
Query: 182 CSMIWGASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQHALLYNVKRHSLE-VRVKD 240
C + + ++ + T + ++ +P+I+M Y + A++ + +K+ E V +D
Sbjct: 176 CYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSR------IKKDKKEPVANQD 229
Query: 241 CVENEDEEG--AEKKEEFQDESEFRRQHEGEVKAKEGRMEAKDGSLKAKEGSTGTSESSV 298
V +G + S+ +H K R + ++ +E + +SV
Sbjct: 230 PVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSV 289
Query: 299 EARGSEEVRESSTVASDGSMEGKEGSTKVEENSMKADKGRTEVNQCSIDLGEDDMEFGED 358
A S +R+ + ++ G +K E + + T+ + +
Sbjct: 290 SAVAS-NMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVG 348
Query: 359 DINFSEDDVEAVNIPESLPPSRRNSNSNPPLPRCYQCKAAKVIFIIIFSYVLSLGPYCFL 418
+ D+ + + + + +++ + PP R + K + I I+ +++++ PY +
Sbjct: 349 SSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSR--EKKVTRTILAILLAFIITWAPYNVM 406
Query: 419 AVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYGYMHKTIKKEIQDML 469
++ + +P V TI WL ++ I+P Y + T KK + +L
Sbjct: 407 VLINTF--CAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 97.1 bits (240), Expect = 3e-20
Identities = 93/471 (19%), Positives = 198/471 (42%), Gaps = 26/471 (5%)
Query: 7 NSTRESNSSHTCM-PLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQV 65
NST SN+S P + + S LV + +GNI++ + ++ L V
Sbjct: 3 NSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLV-----TIIGNILVMVSIKVNRHLQTV 57
Query: 66 TNRFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVV 125
N F+F+L DL+ +V +WPL C ++L ++ + ASV ++++
Sbjct: 58 NNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLII 117
Query: 126 SVDRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGW----GQAAFDERNAL 181
S DRY + PL+YP K T + +++ W+++ + P + W G ++
Sbjct: 118 SFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGE-- 175
Query: 182 CSMIWGASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQHALLYNVKRHSLE-VRVKD 240
C + + ++ + T + ++ +P+I+M Y + A++ + +K+ E V +D
Sbjct: 176 CYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSR------IKKDKKEPVANQD 229
Query: 241 CVENEDEEG--AEKKEEFQDESEFRRQHEGEVKAKEGRMEAKDGSLKAKEGSTGTSESSV 298
V +G + S+ +H K R + ++ +E + +SV
Sbjct: 230 PVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSV 289
Query: 299 EARGSEEVRESSTVASDGSMEGKEGSTKVEENSMKADKGRTEVNQCSIDLGEDDMEFGED 358
A S +R+ + ++ G +K E + + T+ + +
Sbjct: 290 SAVAS-NMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVG 348
Query: 359 DINFSEDDVEAVNIPESLPPSRRNSNSNPPLPRCYQCKAAKVIFIIIFSYVLSLGPYCFL 418
+ D+ + + + + +++ + PP R + K + I I+ +++++ PY +
Sbjct: 349 SSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSR--EKKVTRTILAILLAFIITWAPYNVM 406
Query: 419 AVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYGYMHKTIKKEIQDML 469
++ + +P V TI WL ++ I+P Y + T KK + +L
Sbjct: 407 VLINTF--CAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 97.1 bits (240), Expect = 3e-20
Identities = 93/471 (19%), Positives = 198/471 (42%), Gaps = 26/471 (5%)
Query: 7 NSTRESNSSHTCM-PLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQV 65
NST SN+S P + + S LV + +GNI++ + ++ L V
Sbjct: 3 NSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLV-----TIIGNILVMVSIKVNRHLQTV 57
Query: 66 TNRFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVV 125
N F+F+L DL+ +V +WPL C ++L ++ + ASV ++++
Sbjct: 58 NNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLII 117
Query: 126 SVDRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGW----GQAAFDERNAL 181
S DRY + PL+YP K T + +++ W+++ + P + W G ++
Sbjct: 118 SFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGE-- 175
Query: 182 CSMIWGASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQHALLYNVKRHSLE-VRVKD 240
C + + ++ + T + ++ +P+I+M Y + A++ + +K+ E V +D
Sbjct: 176 CYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSR------IKKDKKEPVANQD 229
Query: 241 CVENEDEEG--AEKKEEFQDESEFRRQHEGEVKAKEGRMEAKDGSLKAKEGSTGTSESSV 298
V +G + S+ +H K R + ++ +E + +SV
Sbjct: 230 PVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSV 289
Query: 299 EARGSEEVRESSTVASDGSMEGKEGSTKVEENSMKADKGRTEVNQCSIDLGEDDMEFGED 358
A S +R+ + ++ G +K E + + T+ + +
Sbjct: 290 SAVAS-NMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVG 348
Query: 359 DINFSEDDVEAVNIPESLPPSRRNSNSNPPLPRCYQCKAAKVIFIIIFSYVLSLGPYCFL 418
+ D+ + + + + +++ + PP R + K + I I+ +++++ PY +
Sbjct: 349 SSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSR--EKKVTRTILAILLAFIITWAPYNVM 406
Query: 419 AVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYGYMHKTIKKEIQDML 469
++ + +P V TI WL ++ I+P Y + T KK + +L
Sbjct: 407 VLINTF--CAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 97.1 bits (240), Expect = 3e-20
Identities = 93/471 (19%), Positives = 198/471 (42%), Gaps = 26/471 (5%)
Query: 7 NSTRESNSSHTCM-PLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQV 65
NST SN+S P + + S LV + +GNI++ + ++ L V
Sbjct: 3 NSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLV-----TIIGNILVMVSIKVNRHLQTV 57
Query: 66 TNRFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVV 125
N F+F+L DL+ +V +WPL C ++L ++ + ASV ++++
Sbjct: 58 NNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLII 117
Query: 126 SVDRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGW----GQAAFDERNAL 181
S DRY + PL+YP K T + +++ W+++ + P + W G ++
Sbjct: 118 SFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGE-- 175
Query: 182 CSMIWGASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQHALLYNVKRHSLE-VRVKD 240
C + + ++ + T + ++ +P+I+M Y + A++ + +K+ E V +D
Sbjct: 176 CYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSR------IKKDKKEPVANQD 229
Query: 241 CVENEDEEG--AEKKEEFQDESEFRRQHEGEVKAKEGRMEAKDGSLKAKEGSTGTSESSV 298
V +G + S+ +H K R + ++ +E + +SV
Sbjct: 230 PVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSV 289
Query: 299 EARGSEEVRESSTVASDGSMEGKEGSTKVEENSMKADKGRTEVNQCSIDLGEDDMEFGED 358
A S +R+ + ++ G +K E + + T+ + +
Sbjct: 290 SAVAS-NMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVG 348
Query: 359 DINFSEDDVEAVNIPESLPPSRRNSNSNPPLPRCYQCKAAKVIFIIIFSYVLSLGPYCFL 418
+ D+ + + + + +++ + PP R + K + I I+ +++++ PY +
Sbjct: 349 SSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSR--EKKVTRTILAILLAFIITWAPYNVM 406
Query: 419 AVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYGYMHKTIKKEIQDML 469
++ + +P V TI WL ++ I+P Y + T KK + +L
Sbjct: 407 VLINTF--CAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 97.1 bits (240), Expect = 3e-20
Identities = 93/471 (19%), Positives = 198/471 (42%), Gaps = 26/471 (5%)
Query: 7 NSTRESNSSHTCM-PLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQV 65
NST SN+S P + + S LV + +GNI++ + ++ L V
Sbjct: 3 NSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLV-----TIIGNILVMVSIKVNRHLQTV 57
Query: 66 TNRFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVV 125
N F+F+L DL+ +V +WPL C ++L ++ + ASV ++++
Sbjct: 58 NNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLII 117
Query: 126 SVDRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGW----GQAAFDERNAL 181
S DRY + PL+YP K T + +++ W+++ + P + W G ++
Sbjct: 118 SFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGE-- 175
Query: 182 CSMIWGASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQHALLYNVKRHSLE-VRVKD 240
C + + ++ + T + ++ +P+I+M Y + A++ + +K+ E V +D
Sbjct: 176 CYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSR------IKKDKKEPVANQD 229
Query: 241 CVENEDEEG--AEKKEEFQDESEFRRQHEGEVKAKEGRMEAKDGSLKAKEGSTGTSESSV 298
V +G + S+ +H K R + ++ +E + +SV
Sbjct: 230 PVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSV 289
Query: 299 EARGSEEVRESSTVASDGSMEGKEGSTKVEENSMKADKGRTEVNQCSIDLGEDDMEFGED 358
A S +R+ + ++ G +K E + + T+ + +
Sbjct: 290 SAVAS-NMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVG 348
Query: 359 DINFSEDDVEAVNIPESLPPSRRNSNSNPPLPRCYQCKAAKVIFIIIFSYVLSLGPYCFL 418
+ D+ + + + + +++ + PP R + K + I I+ +++++ PY +
Sbjct: 349 SSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSR--EKKVTRTILAILLAFIITWAPYNVM 406
Query: 419 AVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYGYMHKTIKKEIQDML 469
++ + +P V TI WL ++ I+P Y + T KK + +L
Sbjct: 407 VLINTF--CAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 97.1 bits (240), Expect = 3e-20
Identities = 93/471 (19%), Positives = 198/471 (42%), Gaps = 26/471 (5%)
Query: 7 NSTRESNSSHTCM-PLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQV 65
NST SN+S P + + S LV + +GNI++ + ++ L V
Sbjct: 3 NSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLV-----TIIGNILVMVSIKVNRHLQTV 57
Query: 66 TNRFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVV 125
N F+F+L DL+ +V +WPL C ++L ++ + ASV ++++
Sbjct: 58 NNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLII 117
Query: 126 SVDRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGW----GQAAFDERNAL 181
S DRY + PL+YP K T + +++ W+++ + P + W G ++
Sbjct: 118 SFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGE-- 175
Query: 182 CSMIWGASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQHALLYNVKRHSLE-VRVKD 240
C + + ++ + T + ++ +P+I+M Y + A++ + +K+ E V +D
Sbjct: 176 CYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSR------IKKDKKEPVANQD 229
Query: 241 CVENEDEEG--AEKKEEFQDESEFRRQHEGEVKAKEGRMEAKDGSLKAKEGSTGTSESSV 298
V +G + S+ +H K R + ++ +E + +SV
Sbjct: 230 PVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSV 289
Query: 299 EARGSEEVRESSTVASDGSMEGKEGSTKVEENSMKADKGRTEVNQCSIDLGEDDMEFGED 358
A S +R+ + ++ G +K E + + T+ + +
Sbjct: 290 SAVAS-NMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVG 348
Query: 359 DINFSEDDVEAVNIPESLPPSRRNSNSNPPLPRCYQCKAAKVIFIIIFSYVLSLGPYCFL 418
+ D+ + + + + +++ + PP R + K + I I+ +++++ PY +
Sbjct: 349 SSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSR--EKKVTRTILAILLAFIITWAPYNVM 406
Query: 419 AVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYGYMHKTIKKEIQDML 469
++ + +P V TI WL ++ I+P Y + T KK + +L
Sbjct: 407 VLINTF--CAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 97.1 bits (240), Expect = 3e-20
Identities = 93/471 (19%), Positives = 198/471 (42%), Gaps = 26/471 (5%)
Query: 7 NSTRESNSSHTCM-PLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQV 65
NST SN+S P + + S LV + +GNI++ + ++ L V
Sbjct: 3 NSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLV-----TIIGNILVMVSIKVNRHLQTV 57
Query: 66 TNRFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVV 125
N F+F+L DL+ +V +WPL C ++L ++ + ASV ++++
Sbjct: 58 NNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLII 117
Query: 126 SVDRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGW----GQAAFDERNAL 181
S DRY + PL+YP K T + +++ W+++ + P + W G ++
Sbjct: 118 SFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGE-- 175
Query: 182 CSMIWGASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQHALLYNVKRHSLE-VRVKD 240
C + + ++ + T + ++ +P+I+M Y + A++ + +K+ E V +D
Sbjct: 176 CYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSR------IKKDKKEPVANQD 229
Query: 241 CVENEDEEG--AEKKEEFQDESEFRRQHEGEVKAKEGRMEAKDGSLKAKEGSTGTSESSV 298
V +G + S+ +H K R + ++ +E + +SV
Sbjct: 230 PVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSV 289
Query: 299 EARGSEEVRESSTVASDGSMEGKEGSTKVEENSMKADKGRTEVNQCSIDLGEDDMEFGED 358
A S +R+ + ++ G +K E + + T+ + +
Sbjct: 290 SAVAS-NMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVG 348
Query: 359 DINFSEDDVEAVNIPESLPPSRRNSNSNPPLPRCYQCKAAKVIFIIIFSYVLSLGPYCFL 418
+ D+ + + + + +++ + PP R + K + I I+ +++++ PY +
Sbjct: 349 SSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSR--EKKVTRTILAILLAFIITWAPYNVM 406
Query: 419 AVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYGYMHKTIKKEIQDML 469
++ + +P V TI WL ++ I+P Y + T KK + +L
Sbjct: 407 VLINTF--CAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 95.9 bits (237), Expect = 8e-20
Identities = 55/194 (28%), Positives = 97/194 (50%), Gaps = 5/194 (2%)
Query: 32 IIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWVVAT 91
++ ++L + + GN ++ + + +L Q +N I +L + DL V P+V T
Sbjct: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141
Query: 92 S-VPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKMTQRRGYL 150
+ W FC +++ + AS+ T+ V+S+DRYL I PL+YP + +
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201
Query: 151 LLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIWGASPSYTILSVVSFIVIPLIVMIA 210
++ W+++ + PPL+GW Q D++ L S +G YTI S IP+ VM+
Sbjct: 202 MILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFG----YTIYSTAVAFYIPMSVMLF 257
Query: 211 CYSVVFCAARRQHA 224
Y ++ AAR+ A
Sbjct: 258 MYYQIYKAARKSAA 271
Score = 35.0 bits (79), Expect = 0.16
Identities = 16/77 (20%), Positives = 40/77 (51%), Gaps = 2/77 (2%)
Query: 396 KAAKVIFIIIFSYVLSLGPYCFLAVLAVWVDVETQ--VPQWVITIIIWLFFLQCCIHPYV 453
KAA + II+ ++ + P+ L+ ++ + +P WV +WL + I+P++
Sbjct: 324 KAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFI 383
Query: 454 YGYMHKTIKKEIQDMLK 470
Y + ++ ++ + +L+
Sbjct: 384 YAFFNRDLRTTYRSLLQ 400
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 95.9 bits (237), Expect = 8e-20
Identities = 55/194 (28%), Positives = 97/194 (50%), Gaps = 5/194 (2%)
Query: 32 IIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWVVAT 91
++ ++L + + GN ++ + + +L Q +N I +L + DL V P+V T
Sbjct: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141
Query: 92 S-VPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKMTQRRGYL 150
+ W FC +++ + AS+ T+ V+S+DRYL I PL+YP + +
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201
Query: 151 LLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIWGASPSYTILSVVSFIVIPLIVMIA 210
++ W+++ + PPL+GW Q D++ L S +G YTI S IP+ VM+
Sbjct: 202 MILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFG----YTIYSTAVAFYIPMSVMLF 257
Query: 211 CYSVVFCAARRQHA 224
Y ++ AAR+ A
Sbjct: 258 MYYQIYKAARKSAA 271
Score = 35.0 bits (79), Expect = 0.16
Identities = 16/77 (20%), Positives = 40/77 (51%), Gaps = 2/77 (2%)
Query: 396 KAAKVIFIIIFSYVLSLGPYCFLAVLAVWVDVETQ--VPQWVITIIIWLFFLQCCIHPYV 453
KAA + II+ ++ + P+ L+ ++ + +P WV +WL + I+P++
Sbjct: 324 KAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFI 383
Query: 454 YGYMHKTIKKEIQDMLK 470
Y + ++ ++ + +L+
Sbjct: 384 YAFFNRDLRTTYRSLLQ 400
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 95.9 bits (237), Expect = 8e-20
Identities = 55/194 (28%), Positives = 97/194 (50%), Gaps = 5/194 (2%)
Query: 32 IIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWVVAT 91
++ ++L + + GN ++ + + +L Q +N I +L + DL V P+V T
Sbjct: 82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT 141
Query: 92 S-VPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKMTQRRGYL 150
+ W FC +++ + AS+ T+ V+S+DRYL I PL+YP + +
Sbjct: 142 DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201
Query: 151 LLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIWGASPSYTILSVVSFIVIPLIVMIA 210
++ W+++ + PPL+GW Q D++ L S +G YTI S IP+ VM+
Sbjct: 202 MILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFG----YTIYSTAVAFYIPMSVMLF 257
Query: 211 CYSVVFCAARRQHA 224
Y ++ AAR+ A
Sbjct: 258 MYYQIYKAARKSAA 271
Score = 35.0 bits (79), Expect = 0.16
Identities = 16/77 (20%), Positives = 40/77 (51%), Gaps = 2/77 (2%)
Query: 396 KAAKVIFIIIFSYVLSLGPYCFLAVLAVWVDVETQ--VPQWVITIIIWLFFLQCCIHPYV 453
KAA + II+ ++ + P+ L+ ++ + +P WV +WL + I+P++
Sbjct: 324 KAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFI 383
Query: 454 YGYMHKTIKKEIQDMLK 470
Y + ++ ++ + +L+
Sbjct: 384 YAFFNRDLRTTYRSLLQ 400
>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
Length = 414
Score = 95.1 bits (235), Expect = 1e-19
Identities = 61/226 (26%), Positives = 112/226 (49%), Gaps = 11/226 (4%)
Query: 35 STVLVIFLAASFVGNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWVVATSVP 94
+T+L + +A GN+++ + + R+ L TN I +L V DLL +LV PWVV V
Sbjct: 38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 97
Query: 95 LFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSK-MTQRRGYLLLY 153
W + C V+L + AS+ + +S+DRY ++ P+ Y ++ ++RR +++
Sbjct: 98 GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 157
Query: 154 GTWIVAILQSTPPLYGWGQAAFDERNALCSMIWGASPSYTILSVVSFIVIPLIVMIACYS 213
W+++ S P L+G A D+ + A+P++ + S + +P IV + Y
Sbjct: 158 IVWVLSFTISCPLLFGLNNA--DQNECII-----ANPAFVVYSSIVSFYVPFIVTLLVYI 210
Query: 214 VVFCAARRQHALLYNVKRHSLEVRVKDCVENEDEEGAEKKEEFQDE 259
++ RR+ + N KR S R + +E A + +E + E
Sbjct: 211 KIYIVLRRRRKRV-NTKRSSRAFRAH--LRAPLKEAARRAQELEME 253
>gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]
Length = 443
Score = 94.4 bits (233), Expect = 2e-19
Identities = 57/204 (27%), Positives = 103/204 (50%), Gaps = 9/204 (4%)
Query: 35 STVLVIFLAASFVGNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWVVATSVP 94
+T+L + +A GN+++ + + R+ L TN I +L V DLL +LV PWVV V
Sbjct: 38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 97
Query: 95 LFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSK-MTQRRGYLLLY 153
W + C V+L + AS+ + +S+DRY ++ P+ Y ++ ++RR +++
Sbjct: 98 GEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 157
Query: 154 GTWIVAILQSTPPLYGWGQAAFDERNALCSMIWGASPSYTILSVVSFIVIPLIVMIACYS 213
W+++ S P L+G A D+ + A+P++ + S + +P IV + Y
Sbjct: 158 IVWVLSFTISCPLLFGLNNA--DQNECII-----ANPAFVVYSSIVSFYVPFIVTLLVYI 210
Query: 214 VVFCAARRQHALLYNVKRHSLEVR 237
++ RR+ + N KR S R
Sbjct: 211 KIYIVLRRRRKRV-NTKRSSRAFR 233
>gi|15150803 opsin 4 isoform 1 [Homo sapiens]
Length = 478
Score = 92.0 bits (227), Expect = 1e-18
Identities = 59/198 (29%), Positives = 92/198 (46%), Gaps = 9/198 (4%)
Query: 29 AHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWV 88
AH + + +L++ L +GN+ + R L N FI NL V+D L AP
Sbjct: 69 AHYTLGTVILLVGLTG-MLGNLTVIYTFCRSRSLRTPANMFIINLAVSDFLMSFTQAPVF 127
Query: 89 VATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKMTQRRG 148
+S+ W C LF +S+ T+ +++DRYL I PL+ ++RR
Sbjct: 128 FTSSLYKQWLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRA 187
Query: 149 YLLLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIWG------ASPSYTILSVVSFIV 202
+L G W+ A+ S PP +GW +A+ L S W A +YT+L
Sbjct: 188 AFVLLGVWLYALAWSLPPFFGW--SAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFF 245
Query: 203 IPLIVMIACYSVVFCAAR 220
+PL+++I CY +F A R
Sbjct: 246 LPLLIIIYCYIFIFRAIR 263
Score = 31.6 bits (70), Expect = 1.8
Identities = 12/29 (41%), Positives = 21/29 (72%)
Query: 394 QCKAAKVIFIIIFSYVLSLGPYCFLAVLA 422
+CK AK++ ++I +VLS PY +A++A
Sbjct: 291 ECKMAKIMLLVILLFVLSWAPYSAVALVA 319
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 90.5 bits (223), Expect = 3e-18
Identities = 57/192 (29%), Positives = 96/192 (50%), Gaps = 7/192 (3%)
Query: 37 VLVIFLAASFVGNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWVVATSVPLF 96
V+ + + A GN+++ + + +L VTN FI +L DL+ V P+ A +
Sbjct: 39 VMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKM 98
Query: 97 WPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKMTQRRGYLLLYGTW 156
W + +C S+ L AS+ T+ V++VDRY +I P Y S +T+ + +++ W
Sbjct: 99 WTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVW 158
Query: 157 IVAILQSTPPL-YGWGQAAFDE-----RNALCSMIWGASPSYTILSVVSFIVIPLIVMIA 210
IV+ L S P+ W +A E N C + + +Y I S + +PL++M+
Sbjct: 159 IVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFF-TNQAYAIASSIVSFYVPLVIMVF 217
Query: 211 CYSVVFCAARRQ 222
YS VF A+RQ
Sbjct: 218 VYSRVFQEAKRQ 229
>gi|5730019 peropsin [Homo sapiens]
Length = 337
Score = 90.5 bits (223), Expect = 3e-18
Identities = 62/227 (27%), Positives = 103/227 (45%), Gaps = 20/227 (8%)
Query: 30 HGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWVV 89
H I+ +T L++ S + NI++ + + +L TN I NL VTD+ S+ P
Sbjct: 25 HNIV-ATYLIMAGMISIISNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSA 83
Query: 90 ATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKMTQRRGY 149
A+ + W C L F AS+ + VV+VDRYL+I P +MT
Sbjct: 84 ASDLYGSWKFGYAGCQVYAGLNIFFGMASIGLLTVVAVDRYLTICLP-DVGRRMTTNTYI 142
Query: 150 LLLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIWGASP----SYTILSVVSFIVIPL 205
L+ G WI + + P+ GW A D A C++ W + SYT+ + ++PL
Sbjct: 143 GLILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDRSFVSYTMTVIAINFIVPL 202
Query: 206 IVMIACYSVVFCAARRQHALLYNVKRHSLEVRVKDCVENEDEEGAEK 252
VM CY + + ++K H+ DC E+ + + +++
Sbjct: 203 TVMFYCY----------YHVTLSIKHHT----TSDCTESLNRDWSDQ 235
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 90.1 bits (222), Expect = 4e-18
Identities = 66/228 (28%), Positives = 110/228 (48%), Gaps = 19/228 (8%)
Query: 20 PLSKMPISLAH------GIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVTNRFIFNL 73
P S+ P L+ G++ + ++++ +A GN+++ + + + P+L +TN FI +L
Sbjct: 45 PASESPEPLSQQWTAGMGLLMALIVLLIVA----GNVLVIVAIAKTPRLQTLTNLFIMSL 100
Query: 74 LVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSI 133
DL+ LV P+ V W S FC S+ L AS+ T+ V+++DRYL+I
Sbjct: 101 ASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAI 160
Query: 134 IHPLSYPSKMTQRRGYLLLYGTWIVAILQS-TPPLYGWGQAAFDERN------ALCSMIW 186
P Y S +T+ R L+ W ++ L S P L W +A DE C +
Sbjct: 161 TSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFV- 219
Query: 187 GASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQHALLYNVKRHSL 234
+ +Y I S V +PL +M Y VF A++Q + + +R L
Sbjct: 220 -TNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFL 266
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 89.4 bits (220), Expect = 7e-18
Identities = 56/200 (28%), Positives = 98/200 (49%), Gaps = 6/200 (3%)
Query: 33 IRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWVVATS 92
+ +L + + A+ GN+++ + + P+L +TN F+ +L DL+ LV P +
Sbjct: 39 LAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLA 98
Query: 93 VPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKMTQRRGYLLL 152
+ WPL + C S+ L AS+ T+ ++VDRYL++ +PL Y + +T+R +
Sbjct: 99 LTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAV 158
Query: 153 YGTWIVAILQSTPPLYG-WGQAAFDERNALC-----SMIWGASPSYTILSVVSFIVIPLI 206
W+V+ S P+ W + D C + ++ Y +LS +PL+
Sbjct: 159 VLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLL 218
Query: 207 VMIACYSVVFCAARRQHALL 226
VM+ Y+ VF A RQ LL
Sbjct: 219 VMLFVYARVFVVATRQLRLL 238
>gi|31083315 G protein-coupled receptor 45 [Homo sapiens]
Length = 372
Score = 89.0 bits (219), Expect = 9e-18
Identities = 56/234 (23%), Positives = 109/234 (46%), Gaps = 14/234 (5%)
Query: 7 NSTRESNSSHTCMPLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVT 66
N++ S+S T +P + + ISLA V+++ F+GN V+ +++ ++P +
Sbjct: 17 NTSNASDSGSTQLP-APLRISLA------IVMLLMTVVGFLGNTVVCIIVYQRPAMRSAI 69
Query: 67 NRFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVS 126
N + L +D++ P+ T + + W HFC +L F V ++++S
Sbjct: 70 NLLLATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIIS 129
Query: 127 VDRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIW 186
VDR+L I+ K+ RR +++ +W+++ + P L GW R C + +
Sbjct: 130 VDRFLIIV---QRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGY 186
Query: 187 GASP---SYTILSVVSFIVIPLIVMIACYSVVFCAARRQHALLYNVKRHSLEVR 237
P +Y + VV+ P VM+ Y + R+ ++N + SL++R
Sbjct: 187 TELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHN-QSDSLDLR 239
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,176,381
Number of Sequences: 37866
Number of extensions: 842507
Number of successful extensions: 7800
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 616
Number of HSP's successfully gapped in prelim test: 416
Number of HSP's that attempted gapping in prelim test: 5299
Number of HSP's gapped (non-prelim): 1919
length of query: 508
length of database: 18,247,518
effective HSP length: 107
effective length of query: 401
effective length of database: 14,195,856
effective search space: 5692538256
effective search space used: 5692538256
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.