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Search of human proteins with 167621456
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|167621456 kinase suppressor of ras 2 [Homo sapiens]
(921 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|167621456 kinase suppressor of ras 2 [Homo sapiens] 1914 0.0
gi|75677325 kinase suppressor of ras [Homo sapiens] 653 0.0
gi|33188459 B-Raf [Homo sapiens] 203 7e-52
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 179 1e-44
gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Hom... 178 2e-44
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 114 3e-25
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 114 3e-25
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 109 1e-23
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 109 1e-23
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 108 2e-23
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 108 3e-23
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 103 7e-22
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 102 1e-21
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 102 1e-21
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 102 1e-21
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 102 1e-21
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 100 1e-20
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 100 1e-20
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 99 2e-20
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 97 9e-20
gi|4503787 fyn-related kinase [Homo sapiens] 95 3e-19
gi|187475373 c-src tyrosine kinase [Homo sapiens] 93 1e-18
gi|4758078 c-src tyrosine kinase [Homo sapiens] 93 1e-18
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 93 1e-18
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 91 4e-18
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 91 4e-18
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 91 4e-18
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 91 4e-18
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 91 6e-18
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 91 6e-18
>gi|167621456 kinase suppressor of ras 2 [Homo sapiens]
Length = 921
Score = 1914 bits (4957), Expect = 0.0
Identities = 921/921 (100%), Positives = 921/921 (100%)
Query: 1 MIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGF 60
MIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGF
Sbjct: 1 MIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGF 60
Query: 61 PQLRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLS 120
PQLRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLS
Sbjct: 61 PQLRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLS 120
Query: 121 CLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHY 180
CLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHY
Sbjct: 121 CLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHY 180
Query: 181 CHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVT 240
CHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVT
Sbjct: 181 CHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVT 240
Query: 241 TVTPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPK 300
TVTPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPK
Sbjct: 241 TVTPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPK 300
Query: 301 AKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFS 360
AKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFS
Sbjct: 301 AKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFS 360
Query: 361 ANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKC 420
ANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKC
Sbjct: 361 ANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKC 420
Query: 421 TKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHI 480
TKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHI
Sbjct: 421 TKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHI 480
Query: 481 PVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKY 540
PVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKY
Sbjct: 481 PVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKY 540
Query: 541 KQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESE 600
KQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESE
Sbjct: 541 KQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESE 600
Query: 601 DDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEV 660
DDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEV
Sbjct: 601 DDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEV 660
Query: 661 AIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYS 720
AIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYS
Sbjct: 661 AIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYS 720
Query: 721 VVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSI 780
VVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSI
Sbjct: 721 VVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSI 780
Query: 781 SGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHA 840
SGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHA
Sbjct: 781 SGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHA 840
Query: 841 REWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLE 900
REWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLE
Sbjct: 841 REWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLE 900
Query: 901 KLPKRNRRLSHPGHFWKSAEL 921
KLPKRNRRLSHPGHFWKSAEL
Sbjct: 901 KLPKRNRRLSHPGHFWKSAEL 921
>gi|75677325 kinase suppressor of ras [Homo sapiens]
Length = 762
Score = 653 bits (1684), Expect = 0.0
Identities = 336/577 (58%), Positives = 423/577 (73%), Gaps = 36/577 (6%)
Query: 370 SPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHL 429
SPQ+ RRD+G S+ HRFSTK W+SQ C VC K M+FG+KCK+C+LKCHNKCTKEAP C +
Sbjct: 197 SPQMVRRDIGLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRI 256
Query: 430 LIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSS 489
+ RL RTESVP DINNP+ R ++ H TLPK K+H P DSS
Sbjct: 257 SFLPL---TRLRRTESVPSDINNPV---DRAAEPHFG-TLPKA-LTKKEHPPAMNHLDSS 308
Query: 490 SNPSSTTSSTPSSPAPPLPPSATPPSPLHP-SPQCTRQQKNFNLPASHYYKYKQQFIFPD 548
SNPSSTTSSTPSSPAP P S+ P S P +P ++ FN PA+++ ++QQFIFP
Sbjct: 309 SNPSSTTSSTPSSPAP-FPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFP- 366
Query: 549 VVP----------VPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHD---- 594
VP + E+ I + P+ E +++ +P ++ E H+
Sbjct: 367 -VPSAGHCWKCLLIAESLKENAFNISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAE 425
Query: 595 -------EAEESEDDFEEMNLSLLSARS-FPRKASQTSIFLQEWDIPFEQLEIGELIGKG 646
EAE+ ED+ +++ S R RKASQTS++LQEWDIPFEQ+E+GE IG+G
Sbjct: 426 EPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQG 485
Query: 647 RFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHL 706
R+G+V+ GRWHGEVAIRL++++ N+D LK FK+EVM YRQTRHENVVLFMGACM+PPHL
Sbjct: 486 RWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHL 545
Query: 707 AIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYD 766
AIITS CKGRTL+S VRD K LD+NKTRQIAQEI+KGMGYLHAKGI+HKDLKSKNVFYD
Sbjct: 546 AIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYD 605
Query: 767 NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHS 826
NGKVVITDFGLF ISGV++ GRRE++L++ + WLC+LAPEI+R+++P +ED+LPFSK +
Sbjct: 606 NGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAA 665
Query: 827 DVFALGTIWYELHAREWPFKTQPAEAIIWQMGT--GMKPNLSQIGMGKEISDILLFCWAF 884
DV+A GT+WYEL AR+WP K Q AEA IWQ+G+ GMK L+ + +GKE+S+IL CWAF
Sbjct: 666 DVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAF 725
Query: 885 EQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL 921
+ +ERP+F+ LMDMLEKLPK NRRLSHPGHFWKSAEL
Sbjct: 726 DLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSAEL 762
Score = 94.7 bits (234), Expect = 3e-19
Identities = 74/214 (34%), Positives = 101/214 (47%), Gaps = 40/214 (18%)
Query: 93 MTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQD--WTI--------QWP 142
M + +V ET+ + GA+ +EC RL +L+CLR V GG K+D W+ P
Sbjct: 1 MNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGE-HKEDSSWSSLDARRESGSGP 59
Query: 143 TTETGKENNPVCPPEPTPWIRT-HLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVD 201
+T+T + PP + R + +Q PR S SPTP +
Sbjct: 60 STDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALP-ASDSPTPSFS----------E 108
Query: 202 AYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGT 261
C P H S +PR H+ +TPP TP +R+ KLKPP T
Sbjct: 109 GLSDTCIPL-----HASGRLTPRALHSF------------ITPPTTPQLRRHTKLKPPRT 151
Query: 262 PPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDE 295
PPP SRK+ L+P F L RSKSHE QLG+R+D+
Sbjct: 152 PPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDD 185
>gi|33188459 B-Raf [Homo sapiens]
Length = 766
Score = 203 bits (516), Expect = 7e-52
Identities = 158/555 (28%), Positives = 262/555 (47%), Gaps = 84/555 (15%)
Query: 384 HRFSTKYWMSQT-CTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVR 442
H F K + + C C K + G +C+ C K H +C+ E P L+ D L
Sbjct: 235 HNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVP----LMCVNYDQLDL-- 288
Query: 443 TESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSS 502
L +S+ +H P+P + S + + T+ S+PS+
Sbjct: 289 --------------------LFVSKFF--------EHHPIPQEEASLAETALTSGSSPSA 320
Query: 503 PAP----------PLPPSATP-PSPLHPSPQCTRQQ-----KNFNLPASHYYKYKQQFIF 546
PA P P + P P P P+ + R Q ++ + P H + I
Sbjct: 321 PASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNI- 379
Query: 547 PDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEM 606
D++ T L G+ L ++ S + ++ S +D M
Sbjct: 380 DDLIRDQGFRGDGGSTTGLSATPPASLPGS-LTNVKALQKSPGPQRERKSSSSSEDRNRM 438
Query: 607 NLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLID 666
++ R+ S +W+IP Q+ +G+ IG G FG VY G+WHG+VA+++++
Sbjct: 439 -------KTLGRRDSS-----DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLN 486
Query: 667 IERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAK 726
+ QL+AFK EV R+TRH N++LFMG + P LAI+T C+G +LY + +
Sbjct: 487 VTAPTPQQLQAFKNEVGVLRKTRHVNILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHIIE 545
Query: 727 IVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVF-YDNGKVVITDFGLFSISGVLQ 785
++ K IA++ +GM YLHAK I+H+DLKS N+F +++ V I DFGL ++
Sbjct: 546 TKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS 605
Query: 786 AGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPF 845
+ ++L +G + +APE+IR +DK P+S SDV+A G + YEL + P+
Sbjct: 606 GSHQFEQL---SGSILWMAPEVIRM------QDKNPYSFQSDVYAFGIVLYELMTGQLPY 656
Query: 846 KT-QPAEAIIWQMGTG-MKPNLSQI--GMGKEISDILLFCWAFEQEERPTFTKLMDMLE- 900
+ II+ +G G + P+LS++ K + ++ C +++ERP F +++ +E
Sbjct: 657 SNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIEL 716
Query: 901 ---KLPKRNRRLSHP 912
LPK +R S P
Sbjct: 717 LARSLPKIHRSASEP 731
>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
sapiens]
Length = 648
Score = 179 bits (454), Expect = 1e-44
Identities = 159/572 (27%), Positives = 244/572 (42%), Gaps = 130/572 (22%)
Query: 384 HRFSTKYWMSQT-CTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPC--------HLLIIHR 434
H F+ K ++ C +C K +L G +C+ C K H C+ + P LL+
Sbjct: 139 HNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPN 198
Query: 435 ---GD------PARLVRT--ESVPCDINNPLRKPPRYSDLH--------------ISQTL 469
GD P+ +R ESV P+ RYS H +SQ
Sbjct: 199 STIGDSGVPALPSLTMRRMRESVS---RMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQ 255
Query: 470 PKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKN 529
T+ N + DS + S + S+ PSA SP + SP Q K
Sbjct: 256 RSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESAS-----PSALSSSPNNLSPTGWSQPKT 310
Query: 530 FNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSEN 589
PVP RAP V T E
Sbjct: 311 ---------------------PVPAQRERAP----------------------VSGTQEK 327
Query: 590 EEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFG 649
++ PR +S + W+I ++ + IG G FG
Sbjct: 328 NKIR-----------------------PRGQRDSSYY---WEIEASEVMLSTRIGSGSFG 361
Query: 650 QVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAII 709
VY G+WHG+VA++++ + +Q +AF+ EV R+TRH N++LFMG M+ +LAI+
Sbjct: 362 TVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMG-YMTKDNLAIV 420
Query: 710 TSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGK 769
T C+G +LY + + + + IA++ +GM YLHAK I+H+D+KS N+F G
Sbjct: 421 TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL 480
Query: 770 VV-ITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDV 828
V I DFGL ++ ++ ++ G + +APE+IR +D PFS SDV
Sbjct: 481 TVKIGDFGLATVKSRWSGSQQVEQ---PTGSVLWMAPEVIRM------QDNNPFSFQSDV 531
Query: 829 FALGTIWYELHAREWPFK-TQPAEAIIWQMGTG-MKPNLSQI--GMGKEISDILLFCWAF 884
++ G + YEL E P+ + II+ +G G P+LS++ K + ++ C
Sbjct: 532 YSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKK 591
Query: 885 EQEERPTFTKLMDMLE----KLPKRNRRLSHP 912
+EERP F +++ +E LPK NR S P
Sbjct: 592 VKEERPLFPQILSSIELLQHSLPKINRSASEP 623
>gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Homo
sapiens]
Length = 606
Score = 178 bits (452), Expect = 2e-44
Identities = 106/292 (36%), Positives = 166/292 (56%), Gaps = 19/292 (6%)
Query: 630 WDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTR 689
W++P ++++ + IG G FG V+ GRWHG+VA++++ + + +Q +AFK E+ R+TR
Sbjct: 303 WEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTR 362
Query: 690 HENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLH 749
H N++LFMG M+ P AIIT C+G +LY + A D+ + +A++ +GM YLH
Sbjct: 363 HVNILLFMG-FMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLH 421
Query: 750 AKGILHKDLKSKNVFYDNGKVV-ITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEII 808
AK I+H+DLKS N+F G V I DFGL ++ + L +G + +A E+I
Sbjct: 422 AKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQ---PLEQPSGSVLWMAAEVI 478
Query: 809 RQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFK-TQPAEAIIWQMGTG-MKPNLS 866
R P+ P+S SDV+A G + YEL P+ + II+ +G G + P+LS
Sbjct: 479 RMQDPN------PYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLS 532
Query: 867 QIGMG--KEISDILLFCWAFEQEERPTFTKLMDMLE----KLPKRNRRLSHP 912
+I K + +L C F++EERP F +++ +E LPK R S P
Sbjct: 533 KISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEP 584
Score = 35.0 bits (79), Expect = 0.32
Identities = 30/126 (23%), Positives = 54/126 (42%), Gaps = 15/126 (11%)
Query: 384 HRFSTKYWMSQT-CTVCGKGMLFGLKCKNCKLKCHNKCTKEAPP-CHLLIIHRGDPARLV 441
H F K + S C C K + G +C+ C K H C+ + P C + +R V
Sbjct: 99 HNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSV 158
Query: 442 RTESVPCDINNPLRKPPRYSDLHISQTL------PKTNKINKDHIPVPYQPDSSSNPSST 495
+ D++ R+ S+ +++ L P+T + +H P P P ++
Sbjct: 159 Q------DLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFP-APANAPLQRIR 211
Query: 496 TSSTPS 501
++STP+
Sbjct: 212 STSTPN 217
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 114 bits (286), Expect = 3e-25
Identities = 89/279 (31%), Positives = 142/279 (50%), Gaps = 24/279 (8%)
Query: 632 IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDN----EDQLKAFKREVMAYRQ 687
+ ++E E+IG G FG+VY GR ++ I R N + + F REV Q
Sbjct: 458 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVA--IKRYRANTYCSKSDVDMFCREVSILCQ 515
Query: 688 TRHENVVLFMGACMSPP-HLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMG 746
H V+ F+GAC++ P AI+T G +L+S++ + K +LD+ IA ++ KGM
Sbjct: 516 LNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGME 575
Query: 747 YLH--AKGILHKDLKSKNV-FYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHL 803
YLH + I+H+DL S N+ Y++G V+ DFG S LQ+ ED + Q G L +
Sbjct: 576 YLHNLTQPIIHRDLNSHNILLYEDGHAVVADFG---ESRFLQS-LDEDNMTKQPGNLRWM 631
Query: 804 APEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPF-KTQPAEAIIWQMGTGMK 862
APE+ Q + ++ +DVF+ +E+ E PF +PA A ++
Sbjct: 632 APEVFTQCT--------RYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIR 683
Query: 863 PNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEK 901
P + + K IS +L+ W E RP F++++ LE+
Sbjct: 684 PPIG-YSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEE 721
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 114 bits (286), Expect = 3e-25
Identities = 89/279 (31%), Positives = 142/279 (50%), Gaps = 24/279 (8%)
Query: 632 IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDN----EDQLKAFKREVMAYRQ 687
+ ++E E+IG G FG+VY GR ++ I R N + + F REV Q
Sbjct: 559 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVA--IKRYRANTYCSKSDVDMFCREVSILCQ 616
Query: 688 TRHENVVLFMGACMSPP-HLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMG 746
H V+ F+GAC++ P AI+T G +L+S++ + K +LD+ IA ++ KGM
Sbjct: 617 LNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGME 676
Query: 747 YLH--AKGILHKDLKSKNV-FYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHL 803
YLH + I+H+DL S N+ Y++G V+ DFG S LQ+ ED + Q G L +
Sbjct: 677 YLHNLTQPIIHRDLNSHNILLYEDGHAVVADFG---ESRFLQS-LDEDNMTKQPGNLRWM 732
Query: 804 APEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPF-KTQPAEAIIWQMGTGMK 862
APE+ Q + ++ +DVF+ +E+ E PF +PA A ++
Sbjct: 733 APEVFTQCT--------RYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIR 784
Query: 863 PNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEK 901
P + + K IS +L+ W E RP F++++ LE+
Sbjct: 785 PPIG-YSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEE 822
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 109 bits (273), Expect = 1e-23
Identities = 81/271 (29%), Positives = 132/271 (48%), Gaps = 31/271 (11%)
Query: 630 WDIPFEQLEIGELIGKGRFGQVYHGRWHG-EVAIRLIDIERDNEDQLKAFKREVMAYRQT 688
W++PFE++ + +G G G V+ GR+HG EVA++ + RD ++ ++ R+
Sbjct: 118 WEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKV---RDLKE------TDIKHLRKL 168
Query: 689 RHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYL 748
+H N++ F G C P I+ C LY V+R + V + + I GM YL
Sbjct: 169 KHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTP-SLLVDWSMGIAGGMNYL 227
Query: 749 HAKGILHKDLKSKNVFYDNGKVV-ITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEI 807
H I+H+DLKS N+ VV I+DFG + + K+ G + +APE+
Sbjct: 228 HLHKIIHRDLKSPNMLITYDDVVKISDFGTSK-----ELSDKSTKMSFA-GTVAWMAPEV 281
Query: 808 IRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGM--KPNL 865
IR P S+ D+++ G + +EL E P+K + AIIW +G+ P
Sbjct: 282 IR---------NEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVP 332
Query: 866 SQIGMGKEISDILLFCWAFEQEERPTFTKLM 896
S G +I +L CW + RP+F +++
Sbjct: 333 SSCPDGFKI--LLRQCWNSKPRNRPSFRQIL 361
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 109 bits (273), Expect = 1e-23
Identities = 85/296 (28%), Positives = 135/296 (45%), Gaps = 44/296 (14%)
Query: 632 IPFEQLEIGELIGKGRFGQVYHGRWHG-EVAIRLI--DIERDNEDQLKAFKREVMAYRQT 688
+ FE+LE+ ELIG G FGQVY W G EVA++ D E+D ++ +RE +
Sbjct: 119 VAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAML 178
Query: 689 RHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLD-----VNKTRQI------ 737
RH N++ G C+ PHL ++ +G L + A D + R+I
Sbjct: 179 RHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLV 238
Query: 738 --AQEIVKGMGYLHAKG---ILHKDLKSKNVF------YD---NGKVVITDFGLFSISGV 783
A +I +GM YLH + ILH+DLKS N+ +D N + ITDFGL
Sbjct: 239 NWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGL------ 292
Query: 784 LQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREW 843
+ R K+ G +APE+I+ FSK SD+++ G + +EL E
Sbjct: 293 AREWHRTTKMSTA-GTYAWMAPEVIKSSL---------FSKGSDIWSYGVLLWELLTGEV 342
Query: 844 PFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDML 899
P++ A+ + + + + ++ CW + RP+F +++ L
Sbjct: 343 PYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQL 398
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 108 bits (271), Expect = 2e-23
Identities = 82/288 (28%), Positives = 135/288 (46%), Gaps = 33/288 (11%)
Query: 627 LQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG-EVAIRLI--DIERDNEDQLKAFKREVM 683
+Q +I F +L + E+IG G FG+VY W G EVA++ D + D ++ ++E
Sbjct: 134 IQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAK 193
Query: 684 AYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVK 743
+ +H N++ G C+ P+L ++ +G L V+ +I D+ A +I +
Sbjct: 194 LFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDI--LVNWAVQIAR 251
Query: 744 GMGYLHAKG---ILHKDLKSKNVF----YDNGK-----VVITDFGLFSISGVLQAGRRED 791
GM YLH + I+H+DLKS N+ +NG + ITDFGL + R
Sbjct: 252 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGL------AREWHRTT 305
Query: 792 KLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAE 851
K+ G +APE+IR FSK SDV++ G + +EL E PF+
Sbjct: 306 KMSAA-GTYAWMAPEVIRASM---------FSKGSDVWSYGVLLWELLTGEVPFRGIDGL 355
Query: 852 AIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDML 899
A+ + + + + ++ CW + RP+FT ++D L
Sbjct: 356 AVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL 403
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 108 bits (269), Expect = 3e-23
Identities = 84/285 (29%), Positives = 136/285 (47%), Gaps = 33/285 (11%)
Query: 631 DIPFEQLEIGELIGKGRFGQVYHGRWHGE-VAIRL--IDIERDNEDQLKAFKREVMAYRQ 687
+IPF +L++ E+IG G FG+VY W GE VA++ +D E+D + +E +
Sbjct: 92 EIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGA 151
Query: 688 TRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGY 747
+H N++ GAC++PPHL ++ +G L V+ ++ V A ++ +GM Y
Sbjct: 152 LQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHV--LVNWAVQVARGMNY 209
Query: 748 LHAKG---ILHKDLKSKNVF----YDNGKVV-----ITDFGLFSISGVLQAGRREDKLRI 795
LH I+H+DLKS N+ +N + ITDFGL + + K+
Sbjct: 210 LHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGL------AREWHKTTKMSA 263
Query: 796 QNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIW 855
G +APE+IR LS FSK SDV++ G + +EL E P++ A A+ +
Sbjct: 264 A-GTYAWMAPEVIR-LS--------LFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAY 313
Query: 856 QMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLE 900
+ + + +L CW + RP F ++ LE
Sbjct: 314 GVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLE 358
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 103 bits (257), Expect = 7e-22
Identities = 102/400 (25%), Positives = 170/400 (42%), Gaps = 45/400 (11%)
Query: 518 HPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAP------QVILHPVTSNP 571
HPSP+ Q+ + + + + V+ +R Q+ H +
Sbjct: 37 HPSPKLLEDQQEKGMVRTELIESVHSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETA 96
Query: 572 ILEGNPLLQIEVEPTSENEEVHDEAEESEDD----FEEMNLSLLSARSFPRKASQTSIFL 627
+ +GN ++ E TS E++ + S E + L + KA T L
Sbjct: 97 VSQGNSNT-VDGESTSGTEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKL 155
Query: 628 QE---WDIPFEQLEIGELIGKGRFGQVYHGRWHGE-VAIRLIDIERDNEDQLKAFKREVM 683
Q+ W++PFE++ + +G G G V+ G++ E VAI+ + NE +K
Sbjct: 156 QQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIK--KVREQNETDIKHL----- 208
Query: 684 AYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVK 743
R+ +H N++ F G C P II C LY V+R + + + I
Sbjct: 209 --RKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITP-RLLVDWSTGIAS 265
Query: 744 GMGYLHAKGILHKDLKSKNVFYDNGKVV-ITDFGLFSISGVLQAGRREDKLRIQNGWLCH 802
GM YLH I+H+DLKS NV + V I+DFG + + K+ G +
Sbjct: 266 GMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSK-----ELSDKSTKMSFA-GTVAW 319
Query: 803 LAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGM- 861
+APE+IR P S+ D+++ G + +EL E P+K + AIIW +G+
Sbjct: 320 MAPEVIR---------NEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL 370
Query: 862 -KPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLE 900
P S G +I ++ W + RP+F + + L+
Sbjct: 371 HLPVPSTCPDGFKI--LMKQTWQSKPRNRPSFRQTLMHLD 408
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 102 bits (255), Expect = 1e-21
Identities = 78/296 (26%), Positives = 145/296 (48%), Gaps = 38/296 (12%)
Query: 631 DIPFEQLEIGELIGKGRFGQVYHGRWHG-EVAIRLIDIERDNEDQLKAFKREVMAYRQTR 689
+I ++++E+ E++G+G FG V +W +VAI+ I ++E + KAF E+ +
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQI----ESESERKAFIVELRQLSRVN 85
Query: 690 HENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIA--QEIVKGMGY 747
H N+V GAC++P + ++ +G +LY+V+ A+ + ++ + +G+ Y
Sbjct: 86 HPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAY 143
Query: 748 LHA---KGILHKDLKSKNVFYDNGKVV--ITDFGLFSISGVLQAGRREDKLRIQNGWLCH 802
LH+ K ++H+DLK N+ G V I DFG A + + G
Sbjct: 144 LHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFG--------TACDIQTHMTNNKGSAAW 195
Query: 803 LAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKT--QPAEAIIWQMGTG 860
+APE+ + +S+ DVF+ G I +E+ R PF PA I+W + G
Sbjct: 196 MAPEVFEGSN---------YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNG 246
Query: 861 MKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL----PKRNRRLSHP 912
+P L + + K I ++ CW+ + +RP+ +++ ++ L P + L +P
Sbjct: 247 TRPPLIK-NLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYP 301
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 102 bits (255), Expect = 1e-21
Identities = 78/296 (26%), Positives = 145/296 (48%), Gaps = 38/296 (12%)
Query: 631 DIPFEQLEIGELIGKGRFGQVYHGRWHG-EVAIRLIDIERDNEDQLKAFKREVMAYRQTR 689
+I ++++E+ E++G+G FG V +W +VAI+ I ++E + KAF E+ +
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQI----ESESERKAFIVELRQLSRVN 85
Query: 690 HENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIA--QEIVKGMGY 747
H N+V GAC++P + ++ +G +LY+V+ A+ + ++ + +G+ Y
Sbjct: 86 HPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAY 143
Query: 748 LHA---KGILHKDLKSKNVFYDNGKVV--ITDFGLFSISGVLQAGRREDKLRIQNGWLCH 802
LH+ K ++H+DLK N+ G V I DFG A + + G
Sbjct: 144 LHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFG--------TACDIQTHMTNNKGSAAW 195
Query: 803 LAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKT--QPAEAIIWQMGTG 860
+APE+ + +S+ DVF+ G I +E+ R PF PA I+W + G
Sbjct: 196 MAPEVFEGSN---------YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNG 246
Query: 861 MKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL----PKRNRRLSHP 912
+P L + + K I ++ CW+ + +RP+ +++ ++ L P + L +P
Sbjct: 247 TRPPLIK-NLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYP 301
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 102 bits (255), Expect = 1e-21
Identities = 78/296 (26%), Positives = 145/296 (48%), Gaps = 38/296 (12%)
Query: 631 DIPFEQLEIGELIGKGRFGQVYHGRWHG-EVAIRLIDIERDNEDQLKAFKREVMAYRQTR 689
+I ++++E+ E++G+G FG V +W +VAI+ I ++E + KAF E+ +
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQI----ESESERKAFIVELRQLSRVN 85
Query: 690 HENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIA--QEIVKGMGY 747
H N+V GAC++P + ++ +G +LY+V+ A+ + ++ + +G+ Y
Sbjct: 86 HPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAY 143
Query: 748 LHA---KGILHKDLKSKNVFYDNGKVV--ITDFGLFSISGVLQAGRREDKLRIQNGWLCH 802
LH+ K ++H+DLK N+ G V I DFG A + + G
Sbjct: 144 LHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFG--------TACDIQTHMTNNKGSAAW 195
Query: 803 LAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKT--QPAEAIIWQMGTG 860
+APE+ + +S+ DVF+ G I +E+ R PF PA I+W + G
Sbjct: 196 MAPEVFEGSN---------YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNG 246
Query: 861 MKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL----PKRNRRLSHP 912
+P L + + K I ++ CW+ + +RP+ +++ ++ L P + L +P
Sbjct: 247 TRPPLIK-NLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYP 301
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 102 bits (255), Expect = 1e-21
Identities = 78/296 (26%), Positives = 145/296 (48%), Gaps = 38/296 (12%)
Query: 631 DIPFEQLEIGELIGKGRFGQVYHGRWHG-EVAIRLIDIERDNEDQLKAFKREVMAYRQTR 689
+I ++++E+ E++G+G FG V +W +VAI+ I ++E + KAF E+ +
Sbjct: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQI----ESESERKAFIVELRQLSRVN 85
Query: 690 HENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIA--QEIVKGMGY 747
H N+V GAC++P + ++ +G +LY+V+ A+ + ++ + +G+ Y
Sbjct: 86 HPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAY 143
Query: 748 LHA---KGILHKDLKSKNVFYDNGKVV--ITDFGLFSISGVLQAGRREDKLRIQNGWLCH 802
LH+ K ++H+DLK N+ G V I DFG A + + G
Sbjct: 144 LHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFG--------TACDIQTHMTNNKGSAAW 195
Query: 803 LAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKT--QPAEAIIWQMGTG 860
+APE+ + +S+ DVF+ G I +E+ R PF PA I+W + G
Sbjct: 196 MAPEVFEGSN---------YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNG 246
Query: 861 MKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL----PKRNRRLSHP 912
+P L + + K I ++ CW+ + +RP+ +++ ++ L P + L +P
Sbjct: 247 TRPPLIK-NLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYP 301
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 99.8 bits (247), Expect = 1e-20
Identities = 73/281 (25%), Positives = 128/281 (45%), Gaps = 38/281 (13%)
Query: 632 IPFEQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDNEDQLKAFKREVMAYRQT 688
I F+ L+ E G G FG VY +W EVA++ +L ++E
Sbjct: 11 IKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVK----------KLLKIEKEAEILSVL 60
Query: 689 RHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKI-VLDVNKTRQIAQEIVKGMGY 747
H N++ F G + PP+ I+T +LY + + +D++ A ++ KGM Y
Sbjct: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120
Query: 748 LHAKG---ILHKDLKSKN-VFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQN--GWLC 801
LH + ++H+DLKS+N V +G + I DFG A R + + G
Sbjct: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFG---------ASRFHNHTTHMSLVGTFP 171
Query: 802 HLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGM 861
+APE+I+ LP S+ D ++ G + +E+ RE PFK + W +
Sbjct: 172 WMAPEVIQ---------SLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKN 222
Query: 862 KPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL 902
+ + +++L CW + ++RP+F +++ +LE +
Sbjct: 223 ERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESM 263
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 99.8 bits (247), Expect = 1e-20
Identities = 73/281 (25%), Positives = 128/281 (45%), Gaps = 38/281 (13%)
Query: 632 IPFEQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDNEDQLKAFKREVMAYRQT 688
I F+ L+ E G G FG VY +W EVA++ +L ++E
Sbjct: 11 IKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVK----------KLLKIEKEAEILSVL 60
Query: 689 RHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKI-VLDVNKTRQIAQEIVKGMGY 747
H N++ F G + PP+ I+T +LY + + +D++ A ++ KGM Y
Sbjct: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120
Query: 748 LHAKG---ILHKDLKSKN-VFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQN--GWLC 801
LH + ++H+DLKS+N V +G + I DFG A R + + G
Sbjct: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFG---------ASRFHNHTTHMSLVGTFP 171
Query: 802 HLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGM 861
+APE+I+ LP S+ D ++ G + +E+ RE PFK + W +
Sbjct: 172 WMAPEVIQ---------SLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKN 222
Query: 862 KPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL 902
+ + +++L CW + ++RP+F +++ +LE +
Sbjct: 223 ERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESM 263
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 99.0 bits (245), Expect = 2e-20
Identities = 74/286 (25%), Positives = 127/286 (44%), Gaps = 37/286 (12%)
Query: 634 FEQLEIGELIGKGRFGQVYHGRWHGE-VAIRLI--DIERDNEDQLKAFKREVMAYRQTRH 690
F++L + E+IG G FG+VY G W GE VA++ D + D ++ ++E + H
Sbjct: 114 FQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAH 173
Query: 691 ENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHA 750
N++ C+ P+L ++ G L + ++ V A +I +GM YLH
Sbjct: 174 PNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHV--LVNWAVQIARGMHYLHC 231
Query: 751 KG---ILHKDLKSKNVF---------YDNGKVVITDFGLFSISGVLQAGRREDKLRIQN- 797
+ ++H+DLKS N+ ++ + ITDFGL R K +
Sbjct: 232 EALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGL---------AREWHKTTQMSA 282
Query: 798 -GWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQ 856
G +APE+I+ + FSK SDV++ G + +EL E P++ A+ +
Sbjct: 283 AGTYAWMAPEVIKAST---------FSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYG 333
Query: 857 MGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL 902
+ + + ++ CWA + RP F ++ LE L
Sbjct: 334 VAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEAL 379
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 96.7 bits (239), Expect = 9e-20
Identities = 72/281 (25%), Positives = 133/281 (47%), Gaps = 17/281 (6%)
Query: 628 QEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKA-FKREVMAYR 686
++W + E + +GEL+GKG FG+VY G + ++ + + D +LK F +E +
Sbjct: 554 KKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILK 613
Query: 687 QTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMG 746
Q H N+V +G C + II L G + +R K L + + + + + GM
Sbjct: 614 QYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGML 673
Query: 747 YLHAKGILHKDLKSKNVFY-DNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAP 805
YL +K +H+DL ++N +N + I+DFG+ R+ED + L +
Sbjct: 674 YLESKNCIHRDLAARNCLVGENNVLKISDFGM---------SRQEDGGVYSSSGLKQIP- 723
Query: 806 EIIRQLSPDTEEDKLPFSKHSDVFALG-TIWYELHAREWPFKTQPAEAIIWQMGTGMKPN 864
I+ +P+ + +S SDV++ G +W P+ + Q+ G + +
Sbjct: 724 --IKWTAPEA-LNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMS 780
Query: 865 LSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKR 905
Q ++IS I++ CW ++ E RP F++L L + ++
Sbjct: 781 APQ-HCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRK 820
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 94.7 bits (234), Expect = 3e-19
Identities = 74/297 (24%), Positives = 134/297 (45%), Gaps = 25/297 (8%)
Query: 627 LQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYR 686
+ +W+I +++ + +G G+FG+V+ G W+ + + ++ + D F RE +
Sbjct: 224 VDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDP-NDFLREAQIMK 282
Query: 687 QTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVR-DAKIVLDVNKTRQIAQEIVKGM 745
RH ++ C + IIT L + +L ++ D + + + +A ++ GM
Sbjct: 283 NLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGM 342
Query: 746 GYLHAKGILHKDLKSKNVFYDNGKVV-ITDFGLFSISGV----LQAGRREDKLRIQNGWL 800
YL ++ +H+DL ++NV + + DFGL + V + R E KL ++ W
Sbjct: 343 AYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVK--W- 399
Query: 801 CHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHA-REWPFKTQPAEAIIWQMGT 859
APE IR FS SDV++ G + YE+ + P+ +I +
Sbjct: 400 --TAPEAIRSNK---------FSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQ 448
Query: 860 GMK-PNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHF 915
+ P S ++ +I+L CW E +ERPTF L LE + + S +F
Sbjct: 449 NYRLPQPS--NCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNF 503
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 93.2 bits (230), Expect = 1e-18
Identities = 73/288 (25%), Positives = 136/288 (47%), Gaps = 27/288 (9%)
Query: 620 ASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG-EVAIRLIDIERDNEDQLKAF 678
A+Q + W + ++L++ + IGKG FG V G + G +VA++ I N+ +AF
Sbjct: 178 AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCI----KNDATAQAF 233
Query: 679 KREVMAYRQTRHENVVLFMGACMSPP-HLAIITS-LCKGRTLYSVVRDAKIVLDVNKTRQ 736
E Q RH N+V +G + L I+T + KG + + + VL + +
Sbjct: 234 LAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLK 293
Query: 737 IAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVV-ITDFGLFSISGVLQAGRREDKLRI 795
+ ++ + M YL +H+DL ++NV V ++DFGL +A +D ++
Sbjct: 294 FSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGL-----TKEASSTQDTGKL 348
Query: 796 QNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHA-REWPFKTQPAEAII 854
W APE +R+ FS SDV++ G + +E+++ P+ P + ++
Sbjct: 349 PVKW---TAPEALREKK---------FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV 396
Query: 855 WQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL 902
++ G K + G + +++ CW + RP+F +L + LE +
Sbjct: 397 PRVEKGYKMDAPD-GCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHI 443
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 93.2 bits (230), Expect = 1e-18
Identities = 73/288 (25%), Positives = 136/288 (47%), Gaps = 27/288 (9%)
Query: 620 ASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG-EVAIRLIDIERDNEDQLKAF 678
A+Q + W + ++L++ + IGKG FG V G + G +VA++ I N+ +AF
Sbjct: 178 AAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCI----KNDATAQAF 233
Query: 679 KREVMAYRQTRHENVVLFMGACMSPP-HLAIITS-LCKGRTLYSVVRDAKIVLDVNKTRQ 736
E Q RH N+V +G + L I+T + KG + + + VL + +
Sbjct: 234 LAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLK 293
Query: 737 IAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVV-ITDFGLFSISGVLQAGRREDKLRI 795
+ ++ + M YL +H+DL ++NV V ++DFGL +A +D ++
Sbjct: 294 FSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGL-----TKEASSTQDTGKL 348
Query: 796 QNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHA-REWPFKTQPAEAII 854
W APE +R+ FS SDV++ G + +E+++ P+ P + ++
Sbjct: 349 PVKW---TAPEALREKK---------FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV 396
Query: 855 WQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL 902
++ G K + G + +++ CW + RP+F +L + LE +
Sbjct: 397 PRVEKGYKMDAPD-GCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHI 443
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 93.2 bits (230), Expect = 1e-18
Identities = 67/274 (24%), Positives = 129/274 (47%), Gaps = 18/274 (6%)
Query: 629 EWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQT 688
+W+ P E+ + +G G FG+V+ G W V + + I RDN + + E+ A ++
Sbjct: 183 DWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKL 242
Query: 689 RHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDA-KIVLDVNKTRQIAQEIVKGMGY 747
RH++++ + IIT L +L ++RD+ + VL V++ IA ++ +GM Y
Sbjct: 243 RHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCY 302
Query: 748 LHAKGILHKDLKSKNVFY-DNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPE 806
L ++ +H+DL ++N+ +N + DFGL + + + I W APE
Sbjct: 303 LESQNYIHRDLAARNILVGENTLCKVGDFGLARL--IKEDVYLSHDHNIPYKW---TAPE 357
Query: 807 IIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAR-EWPFKTQPAEAIIWQMGTGMKPNL 865
+ + +S SDV++ G + +E+ +R + P+ ++ G +
Sbjct: 358 AL---------SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMP- 407
Query: 866 SQIGMGKEISDILLFCWAFEQEERPTFTKLMDML 899
+ + ++L CW + E+RP F L + L
Sbjct: 408 CPLECPPSVHKLMLTCWCRDPEQRPCFKALRERL 441
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 91.3 bits (225), Expect = 4e-18
Identities = 79/290 (27%), Positives = 131/290 (45%), Gaps = 31/290 (10%)
Query: 629 EWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDN-EDQLKA-FKREVMAYR 686
+W + E L +GE IG+G FG+V+ GR + + + R+ LKA F +E +
Sbjct: 425 KWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILK 484
Query: 687 QTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMG 746
Q H N+V +G C + I+ L +G + +R L V Q+ + GM
Sbjct: 485 QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGME 544
Query: 747 YLHAKGILHKDLKSKNVFYDNGKVV-ITDFGLF--SISGVLQA--GRREDKLRIQNGWLC 801
YL +K +H+DL ++N V+ I+DFG+ GV A G R+ ++ W
Sbjct: 545 YLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVK----W-- 598
Query: 802 HLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYE---LHAREWP-FKTQPAEAIIWQM 857
APE + +S SDV++ G + +E L A +P Q + +
Sbjct: 599 -TAPEALNYGR---------YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKG 648
Query: 858 GTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNR 907
G P L + ++ CWA+E +RP+F+ + L+ + KR+R
Sbjct: 649 GRLPCPELCP----DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 694
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 91.3 bits (225), Expect = 4e-18
Identities = 79/290 (27%), Positives = 131/290 (45%), Gaps = 31/290 (10%)
Query: 629 EWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDN-EDQLKA-FKREVMAYR 686
+W + E L +GE IG+G FG+V+ GR + + + R+ LKA F +E +
Sbjct: 483 KWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILK 542
Query: 687 QTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMG 746
Q H N+V +G C + I+ L +G + +R L V Q+ + GM
Sbjct: 543 QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGME 602
Query: 747 YLHAKGILHKDLKSKNVFYDNGKVV-ITDFGLF--SISGVLQA--GRREDKLRIQNGWLC 801
YL +K +H+DL ++N V+ I+DFG+ GV A G R+ ++ W
Sbjct: 603 YLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVK----W-- 656
Query: 802 HLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYE---LHAREWP-FKTQPAEAIIWQM 857
APE + +S SDV++ G + +E L A +P Q + +
Sbjct: 657 -TAPEALNYGR---------YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKG 706
Query: 858 GTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNR 907
G P L + ++ CWA+E +RP+F+ + L+ + KR+R
Sbjct: 707 GRLPCPELCP----DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 752
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 91.3 bits (225), Expect = 4e-18
Identities = 79/290 (27%), Positives = 131/290 (45%), Gaps = 31/290 (10%)
Query: 629 EWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDN-EDQLKA-FKREVMAYR 686
+W + E L +GE IG+G FG+V+ GR + + + R+ LKA F +E +
Sbjct: 495 KWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILK 554
Query: 687 QTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMG 746
Q H N+V +G C + I+ L +G + +R L V Q+ + GM
Sbjct: 555 QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGME 614
Query: 747 YLHAKGILHKDLKSKNVFYDNGKVV-ITDFGLF--SISGVLQA--GRREDKLRIQNGWLC 801
YL +K +H+DL ++N V+ I+DFG+ GV A G R+ ++ W
Sbjct: 615 YLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVK----W-- 668
Query: 802 HLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYE---LHAREWP-FKTQPAEAIIWQM 857
APE + +S SDV++ G + +E L A +P Q + +
Sbjct: 669 -TAPEALNYGR---------YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKG 718
Query: 858 GTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNR 907
G P L + ++ CWA+E +RP+F+ + L+ + KR+R
Sbjct: 719 GRLPCPELCP----DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 764
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 91.3 bits (225), Expect = 4e-18
Identities = 79/290 (27%), Positives = 131/290 (45%), Gaps = 31/290 (10%)
Query: 629 EWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDN-EDQLKA-FKREVMAYR 686
+W + E L +GE IG+G FG+V+ GR + + + R+ LKA F +E +
Sbjct: 553 KWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILK 612
Query: 687 QTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMG 746
Q H N+V +G C + I+ L +G + +R L V Q+ + GM
Sbjct: 613 QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGME 672
Query: 747 YLHAKGILHKDLKSKNVFYDNGKVV-ITDFGLF--SISGVLQA--GRREDKLRIQNGWLC 801
YL +K +H+DL ++N V+ I+DFG+ GV A G R+ ++ W
Sbjct: 673 YLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVK----W-- 726
Query: 802 HLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYE---LHAREWP-FKTQPAEAIIWQM 857
APE + +S SDV++ G + +E L A +P Q + +
Sbjct: 727 -TAPEALNYGR---------YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKG 776
Query: 858 GTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNR 907
G P L + ++ CWA+E +RP+F+ + L+ + KR+R
Sbjct: 777 GRLPCPELCP----DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 90.5 bits (223), Expect = 6e-18
Identities = 67/274 (24%), Positives = 128/274 (46%), Gaps = 27/274 (9%)
Query: 630 WDIPFEQLEIGELIGKGRFGQVYHGRWHGE--VAIRLIDIERDNEDQLKAFKREVMAYRQ 687
W+I + L + +G G+FG V +G+W G+ VAI++I +ED+ F E
Sbjct: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDE---FIEEAKVMMN 451
Query: 688 TRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGY 747
HE +V G C + IIT L + +R+ + + ++ +++ + M Y
Sbjct: 452 LSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEY 511
Query: 748 LHAKGILHKDLKSKN-VFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPE 806
L +K LH+DL ++N + D G V ++DFGL + + + + + +
Sbjct: 512 LESKQFLHRDLAARNCLVNDQGVVKVSDFGL-------------SRYVLDDEYTSSVGSK 558
Query: 807 IIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHA-REWPFKTQPAEAIIWQMGTGM---K 862
+ SP FS SD++A G + +E+++ + P++ + G+ +
Sbjct: 559 FPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYR 618
Query: 863 PNLSQIGMGKEISDILLFCWAFEQEERPTFTKLM 896
P+L+ +++ I+ CW + +ERPTF L+
Sbjct: 619 PHLA----SEKVYTIMYSCWHEKADERPTFKILL 648
>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
Length = 1061
Score = 90.5 bits (223), Expect = 6e-18
Identities = 71/256 (27%), Positives = 124/256 (48%), Gaps = 23/256 (8%)
Query: 664 LIDIERDNEDQLKAFKR---EVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYS 720
L+ ++R N +++ ++ E+ R ++E++ F+GAC PP++ I+T C +L
Sbjct: 563 LVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQD 622
Query: 721 VVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGIL-HKDLKSKNVFYDNGKVV-ITDFGLF 778
++ + I LD + +IVKGM +LH I H +LKS N D V+ ITD+GL
Sbjct: 623 ILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLE 682
Query: 779 SISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYEL 838
S + + + + W APE++R SP S+ DV++ G I E+
Sbjct: 683 SFRDL--DPEQGHTVYAKKLW---TAPELLRMASPPVRG-----SQAGDVYSFGIILQEI 732
Query: 839 HAREWPFKTQ----PAEAIIWQMGTG----MKPNLSQIGMGKEISDILLFCWAFEQEERP 890
R F + + II ++ G +P+L+ +E+ ++ CWA + +ERP
Sbjct: 733 ALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERP 792
Query: 891 TFTKLMDMLEKLPKRN 906
F ++ L K + N
Sbjct: 793 PFQQIRLTLRKFNREN 808
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,136,076
Number of Sequences: 37866
Number of extensions: 2619945
Number of successful extensions: 30345
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 632
Number of HSP's successfully gapped in prelim test: 925
Number of HSP's that attempted gapping in prelim test: 18759
Number of HSP's gapped (non-prelim): 9102
length of query: 921
length of database: 18,247,518
effective HSP length: 112
effective length of query: 809
effective length of database: 14,006,526
effective search space: 11331279534
effective search space used: 11331279534
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.