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Search of human proteins with 110735402
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110735402 protein tyrosine phosphatase, receptor type, U
isoform 3 precursor [Homo sapiens]
(1446 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110735402 protein tyrosine phosphatase, receptor type, U isof... 2968 0.0
gi|110735404 protein tyrosine phosphatase, receptor type, U isof... 2936 0.0
gi|110735406 protein tyrosine phosphatase, receptor type, U isof... 2929 0.0
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 1773 0.0
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 1766 0.0
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 1582 0.0
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 1577 0.0
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 1564 0.0
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 1554 0.0
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 462 e-129
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 461 e-129
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 461 e-129
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 453 e-127
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 449 e-126
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 449 e-126
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 449 e-126
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 449 e-126
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 445 e-124
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 445 e-124
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 445 e-124
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 404 e-112
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 404 e-112
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 404 e-112
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 377 e-104
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo... 377 e-104
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 346 1e-94
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 340 8e-93
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 317 5e-86
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 317 5e-86
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 317 5e-86
>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
precursor [Homo sapiens]
Length = 1446
Score = 2968 bits (7694), Expect = 0.0
Identities = 1446/1446 (100%), Positives = 1446/1446 (100%)
Query: 1 MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT 60
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT
Sbjct: 1 MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT 60
Query: 61 RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY 120
RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY
Sbjct: 61 RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY 120
Query: 121 VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL 180
VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
Sbjct: 121 VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL 180
Query: 181 LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI 240
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI
Sbjct: 181 LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI 240
Query: 241 SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT 300
SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT
Sbjct: 241 SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT 300
Query: 301 YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT 360
YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
Sbjct: 301 YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT 360
Query: 361 RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS 420
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS
Sbjct: 361 RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS 420
Query: 421 LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480
LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ
Sbjct: 421 LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480
Query: 481 TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540
TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR
Sbjct: 481 TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540
Query: 541 RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP 600
RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP
Sbjct: 541 RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP 600
Query: 601 LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG 660
LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG
Sbjct: 601 LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG 660
Query: 661 LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC 720
LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC
Sbjct: 661 LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC 720
Query: 721 IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYS 780
IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYS
Sbjct: 721 IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYS 780
Query: 781 YYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRS 840
YYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRS
Sbjct: 781 YYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRS 840
Query: 841 GGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYES 900
GGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYES
Sbjct: 841 GGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYES 900
Query: 901 FFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIA 960
FFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIA
Sbjct: 901 FFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIA 960
Query: 961 TQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTE 1020
TQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTE
Sbjct: 961 TQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTE 1020
Query: 1021 TLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGP 1080
TLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGP
Sbjct: 1021 TLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGP 1080
Query: 1081 IVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA 1140
IVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA
Sbjct: 1081 IVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA 1140
Query: 1141 ILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALL 1200
ILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALL
Sbjct: 1141 ILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALL 1200
Query: 1201 PRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPD 1260
PRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPD
Sbjct: 1201 PRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPD 1260
Query: 1261 FWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARV 1320
FWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARV
Sbjct: 1261 FWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARV 1320
Query: 1321 FRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHC 1380
FRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHC
Sbjct: 1321 FRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHC 1380
Query: 1381 LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1440
LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
Sbjct: 1381 LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1440
Query: 1441 EGLESR 1446
EGLESR
Sbjct: 1441 EGLESR 1446
>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
precursor [Homo sapiens]
Length = 1436
Score = 2936 bits (7611), Expect = 0.0
Identities = 1436/1446 (99%), Positives = 1436/1446 (99%), Gaps = 10/1446 (0%)
Query: 1 MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT 60
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT
Sbjct: 1 MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT 60
Query: 61 RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY 120
RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY
Sbjct: 61 RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY 120
Query: 121 VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL 180
VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
Sbjct: 121 VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL 180
Query: 181 LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI 240
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI
Sbjct: 181 LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI 240
Query: 241 SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT 300
SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT
Sbjct: 241 SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT 300
Query: 301 YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT 360
YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
Sbjct: 301 YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT 360
Query: 361 RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS 420
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS
Sbjct: 361 RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS 420
Query: 421 LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480
LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ
Sbjct: 421 LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480
Query: 481 TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540
TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR
Sbjct: 481 TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540
Query: 541 RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP 600
RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP
Sbjct: 541 RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP 600
Query: 601 LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG 660
LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG
Sbjct: 601 LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG 660
Query: 661 LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC 720
LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC
Sbjct: 661 LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC 720
Query: 721 IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYS 780
IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKG
Sbjct: 721 IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKG------- 773
Query: 781 YYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRS 840
KPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRS
Sbjct: 774 ---KPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRS 830
Query: 841 GGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYES 900
GGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYES
Sbjct: 831 GGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYES 890
Query: 901 FFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIA 960
FFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIA
Sbjct: 891 FFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIA 950
Query: 961 TQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTE 1020
TQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTE
Sbjct: 951 TQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTE 1010
Query: 1021 TLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGP 1080
TLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGP
Sbjct: 1011 TLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGP 1070
Query: 1081 IVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA 1140
IVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA
Sbjct: 1071 IVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA 1130
Query: 1141 ILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALL 1200
ILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALL
Sbjct: 1131 ILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALL 1190
Query: 1201 PRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPD 1260
PRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPD
Sbjct: 1191 PRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPD 1250
Query: 1261 FWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARV 1320
FWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARV
Sbjct: 1251 FWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARV 1310
Query: 1321 FRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHC 1380
FRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHC
Sbjct: 1311 FRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHC 1370
Query: 1381 LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1440
LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
Sbjct: 1371 LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1430
Query: 1441 EGLESR 1446
EGLESR
Sbjct: 1431 EGLESR 1436
>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
precursor [Homo sapiens]
Length = 1442
Score = 2929 bits (7594), Expect = 0.0
Identities = 1436/1452 (98%), Positives = 1436/1452 (98%), Gaps = 16/1452 (1%)
Query: 1 MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT 60
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT
Sbjct: 1 MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT 60
Query: 61 RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY 120
RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY
Sbjct: 61 RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY 120
Query: 121 VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL 180
VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
Sbjct: 121 VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL 180
Query: 181 LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI 240
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI
Sbjct: 181 LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI 240
Query: 241 SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT 300
SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT
Sbjct: 241 SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT 300
Query: 301 YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT 360
YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
Sbjct: 301 YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT 360
Query: 361 RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS 420
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS
Sbjct: 361 RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS 420
Query: 421 LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480
LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ
Sbjct: 421 LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480
Query: 481 TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540
TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR
Sbjct: 481 TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540
Query: 541 RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP 600
RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP
Sbjct: 541 RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP 600
Query: 601 LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG 660
LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG
Sbjct: 601 LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG 660
Query: 661 LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC 720
LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC
Sbjct: 661 LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC 720
Query: 721 IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYS 780
IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKG
Sbjct: 721 IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKG------- 773
Query: 781 YYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRS 840
KPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRS
Sbjct: 774 ---KPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRS 830
Query: 841 GGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYES 900
GGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYES
Sbjct: 831 GGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYES 890
Query: 901 FFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYID------GYHR 954
FFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYID GYHR
Sbjct: 891 FFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHR 950
Query: 955 SNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKI 1014
SNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKI
Sbjct: 951 SNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKI 1010
Query: 1015 MLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKAST 1074
MLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKAST
Sbjct: 1011 MLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKAST 1070
Query: 1075 PPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQY 1134
PPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQY
Sbjct: 1071 PPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQY 1130
Query: 1135 IFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEE 1194
IFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEE
Sbjct: 1131 IFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEE 1190
Query: 1195 CSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPL 1254
CSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPL
Sbjct: 1191 CSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPL 1250
Query: 1255 QSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADE 1314
QSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADE
Sbjct: 1251 QSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADE 1310
Query: 1315 DLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDG 1374
DLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDG
Sbjct: 1311 DLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDG 1370
Query: 1375 RTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYD 1434
RTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYD
Sbjct: 1371 RTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYD 1430
Query: 1435 VALEYLEGLESR 1446
VALEYLEGLESR
Sbjct: 1431 VALEYLEGLESR 1442
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 1773 bits (4592), Expect = 0.0
Identities = 860/1426 (60%), Positives = 1067/1426 (74%), Gaps = 28/1426 (1%)
Query: 24 AAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQ 83
A GCTF++ C+Y Q YDDF+W V P ++P GSY++V++S H PG+
Sbjct: 33 AGGCTFDDGPGA---CDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGE 89
Query: 84 RAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQW 143
+A + ++ ENDTHC+ FSY LYS+ G +PGTL + VRVN GPL + +WN+TG GR W
Sbjct: 90 KARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDW 149
Query: 144 HQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAG 203
+AELAVSTFWPNEYQV+FEA +S R GY+ +DDI +LSYPC K+PHF RLGDVEVNAG
Sbjct: 150 LRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAG 209
Query: 204 QNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYR 263
QNA+FQC+A GR A + LQR++G +P A ++I+HRRF A+F L V++ +QDLYR
Sbjct: 210 QNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYR 269
Query: 264 CVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIE 323
CV+Q+ RG+GVSNFA+LIV+EPP PIAPPQLL GPTYL+IQLN NSIIGDGPI+ KE+E
Sbjct: 270 CVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVE 329
Query: 324 YRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEP 383
YRM G W E HAV+ TYKLWHLDPDTEYEI VLLTRPG+GGTG PGPPLI+RTKCAEP
Sbjct: 330 YRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEP 389
Query: 384 MRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQ 443
MR PK L AEIQAR++ + WE LGYN+TRCHT+ V++CYHY G HN++ +C+ +
Sbjct: 390 MRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRG--HNESKADCLDMDP 447
Query: 444 GVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMI 503
++ + +L PY NV ++++LTNPEGRKE +E QTDEDVP + +SL T E+ I
Sbjct: 448 KAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKI 507
Query: 504 FLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTY 563
FL W+EP +PNG+ITQYEISY SI S DPAV V GP +T+S L N T+HVF +LHPGTTY
Sbjct: 508 FLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTY 567
Query: 564 LFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPI 622
F +RA T KGFG A +TTNISAP+ DY + + L E+ TITVLLRPAQ +GAPI
Sbjct: 568 QFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPI 627
Query: 623 SVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAMPFTV 682
S YQ++VEE R +RE G +C+ VP+T++ A++ G +YF AEL +LPE PFTV
Sbjct: 628 SAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTV 687
Query: 683 GDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPL-EVSQR 741
GDN+TY+GFWNPPL PRK Y IYFQA S ++ ET+ C+RIA KAA E + + +++
Sbjct: 688 GDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQ 747
Query: 742 SEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYPKPVNMTKATVNYRQEKTH 801
++ + I GI AG + V ILLL +I+I++K + A N RQE TH
Sbjct: 748 TDRVVKIAGISAG-ILVFILLLLVVILIVKKSK---------LAKKRKDAMGNTRQEMTH 797
Query: 802 MMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRK 861
M++A+DRS+ DQSTL ++ L ++FMD H +S R + S T SS L PR C
Sbjct: 798 MVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSA--TAESSRLLDVPRYLCEGT 855
Query: 862 GSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGS 917
SPY TGQLHPA+RVADLLQHIN MKT++ YGFK+EYESFFEG WD KK +
Sbjct: 856 ESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKN 915
Query: 918 RQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVW 977
R + AYD RV L P+ DP++DYINANYIDGY R +H+IATQGP E VYDFWRM+W
Sbjct: 916 RYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIW 975
Query: 978 QEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGY 1037
QE + IVM+T LVEVGRVKC +YWP+D++ YGD K+ V+ E LAEYVVRTF LERRGY
Sbjct: 976 QEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGY 1035
Query: 1038 SARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIV 1097
+ EV+QFHFT WP+HGVPYHATGLL+FIRRVK S PP AGPIV+HCSAG GRTGCYIV
Sbjct: 1036 NEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIV 1095
Query: 1098 LDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEF 1157
+D+MLDMAE EGVVDIYNCVK L SRR+NM+QTEEQYIFIHDAILEACLCGET IPV EF
Sbjct: 1096 IDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEF 1155
Query: 1158 KATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR 1217
KA Y +MIRID Q+NSS L++EFQTLNSVTP L E+CSIA LPRN DKNR MD+LPPDR
Sbjct: 1156 KAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDR 1215
Query: 1218 CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLN 1277
CLPFLI+ DG+S+NYINAAL DSY + AAFIVT +PL +T DFWRLVYDYGCTSIVMLN
Sbjct: 1216 CLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLN 1275
Query: 1278 QLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVR 1337
+++ S C QYWPE G +YG ++VE MS + D D++ R+FR+ N++R QEG+L+V+
Sbjct: 1276 EVDLSQG---CPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQ 1332
Query: 1338 HFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQ--AESGDGRTIVHCLNGGGRSGTFCACAT 1395
FQ+L W+++R+ P SK++FL L+ +V+KWQ E G+GRTI+HCLNGGGRSG FCA
Sbjct: 1333 QFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGI 1392
Query: 1396 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1441
V+EM++ N+VDVF A KTLRN KPNMVE +QY FCYDVALEYLE
Sbjct: 1393 VVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1438
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 1766 bits (4575), Expect = 0.0
Identities = 860/1432 (60%), Positives = 1067/1432 (74%), Gaps = 34/1432 (2%)
Query: 24 AAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQ 83
A GCTF++ C+Y Q YDDF+W V P ++P GSY++V++S H PG+
Sbjct: 33 AGGCTFDDGPGA---CDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGE 89
Query: 84 RAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQW 143
+A + ++ ENDTHC+ FSY LYS+ G +PGTL + VRVN GPL + +WN+TG GR W
Sbjct: 90 KARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDW 149
Query: 144 HQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAG 203
+AELAVSTFWPNEYQV+FEA +S R GY+ +DDI +LSYPC K+PHF RLGDVEVNAG
Sbjct: 150 LRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAG 209
Query: 204 QNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYR 263
QNA+FQC+A GR A + LQR++G +P A ++I+HRRF A+F L V++ +QDLYR
Sbjct: 210 QNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYR 269
Query: 264 CVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIE 323
CV+Q+ RG+GVSNFA+LIV+EPP PIAPPQLL GPTYL+IQLN NSIIGDGPI+ KE+E
Sbjct: 270 CVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVE 329
Query: 324 YRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEP 383
YRM G W E HAV+ TYKLWHLDPDTEYEI VLLTRPG+GGTG PGPPLI+RTKCAEP
Sbjct: 330 YRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEP 389
Query: 384 MRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQ 443
MR PK L AEIQAR++ + WE LGYN+TRCHT+ V++CYHY G HN++ +C+ +
Sbjct: 390 MRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRG--HNESKADCLDMDP 447
Query: 444 GVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMI 503
++ + +L PY NV ++++LTNPEGRKE +E QTDEDVP + +SL T E+ I
Sbjct: 448 KAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKI 507
Query: 504 FLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTY 563
FL W+EP +PNG+ITQYEISY SI S DPAV V GP +T+S L N T+HVF +LHPGTTY
Sbjct: 508 FLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTY 567
Query: 564 LFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPI 622
F +RA T KGFG A +TTNISAP+ DY + + L E+ TITVLLRPAQ +GAPI
Sbjct: 568 QFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPI 627
Query: 623 SVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAMPFTV 682
S YQ++VEE R +RE G +C+ VP+T++ A++ G +YF AEL +LPE PFTV
Sbjct: 628 SAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTV 687
Query: 683 GDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPL-EVSQR 741
GDN+TY+GFWNPPL PRK Y IYFQA S ++ ET+ C+RIA KAA E + + +++
Sbjct: 688 GDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQ 747
Query: 742 SEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYPKPVNMTKATVNYRQEKTH 801
++ + I GI A G+ V ILLL +I+I++K + A N RQE TH
Sbjct: 748 TDRVVKIAGISA-GILVFILLLLVVILIVKKSK---------LAKKRKDAMGNTRQEMTH 797
Query: 802 MMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRK 861
M++A+DRS+ DQSTL ++ L ++FMD H +S R + S T SS L PR C
Sbjct: 798 MVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHS--ATAESSRLLDVPRYLCEGT 855
Query: 862 GSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGS 917
SPY TGQLHPA+RVADLLQHIN MKT++ YGFK+EYESFFEG WD KK +
Sbjct: 856 ESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKN 915
Query: 918 RQEPMPAYDRHRVKLHPMLGDPNADYINANYI------DGYHRSNHFIATQGPKPEMVYD 971
R + AYD RV L P+ DP++DYINANYI DGY R +H+IATQGP E VYD
Sbjct: 916 RYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYD 975
Query: 972 FWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFA 1031
FWRM+WQE + IVM+T LVEVGRVKC +YWP+D++ YGD K+ V+ E LAEYVVRTF
Sbjct: 976 FWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFT 1035
Query: 1032 LERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGR 1091
LERRGY+ EV+QFHFT WP+HGVPYHATGLL+FIRRVK S PP AGPIV+HCSAG GR
Sbjct: 1036 LERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGR 1095
Query: 1092 TGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETT 1151
TGCYIV+D+MLDMAE EGVVDIYNCVK L SRR+NM+QTEEQYIFIHDAILEACLCGET
Sbjct: 1096 TGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETA 1155
Query: 1152 IPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMD 1211
IPV EFKA Y +MIRID Q+NSS L++EFQTLNSVTP L E+CSIA LPRN DKNR MD
Sbjct: 1156 IPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMD 1215
Query: 1212 VLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCT 1271
+LPPDRCLPFLI+ DG+S+NYINAAL DSY + AAFIVT +PL +T DFWRLVYDYGCT
Sbjct: 1216 MLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCT 1275
Query: 1272 SIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQE 1331
SIVMLN+++ S C QYWPE G +YG ++VE MS + D D++ R+FR+ N++R QE
Sbjct: 1276 SIVMLNEVDLSQG---CPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQE 1332
Query: 1332 GHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQ--AESGDGRTIVHCLNGGGRSGT 1389
G+L+V+ FQ+L W+++R+ P SK++FL L+ +V+KWQ E G+GRTI+HCLNGGGRSG
Sbjct: 1333 GYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGM 1392
Query: 1390 FCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1441
FCA V+EM++ N+VDVF A KTLRN KPNMVE +QY FCYDVALEYLE
Sbjct: 1393 FCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1444
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 1582 bits (4096), Expect = 0.0
Identities = 771/1453 (53%), Positives = 1018/1453 (70%), Gaps = 57/1453 (3%)
Query: 21 ETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHA 80
ET + GC F+E P C YSQ++ DDF WEQV + +P GS+++VN S
Sbjct: 21 ETFSGGCLFDE---PYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRP 77
Query: 81 PGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHG 140
GQRAH++ L ENDTHC+ F YF+ S+ PG L VYV+VN GPLG+ +WN++G
Sbjct: 78 EGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPT 137
Query: 141 RQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEV 200
R W++AELA+STFWPN YQV+FE + S +GY+ +D++ +L +PC + PHF R+ +VEV
Sbjct: 138 RTWNRAELAISTFWPNFYQVIFEVITS-GHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEV 196
Query: 201 NAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQD 260
NAGQ A+FQC A GR +R LQ P ++ S RRF+A+F + ++ +
Sbjct: 197 NAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAG 256
Query: 261 LYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRK 320
YRC+ + G G+SN+AEL+VKEPP PIAPPQL G TYL IQLN NSI GDGPIV +
Sbjct: 257 KYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAR 316
Query: 321 EIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKC 380
E+EY A G W + V +YK+ HLDPDTEYEISVLLTRPG+GGTG PGP L +RTKC
Sbjct: 317 EVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKC 376
Query: 381 AEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440
A+PMR P+ L E+++RQ+T++WEP GYNVTRCH+Y +++ Y Y +G + +RE V
Sbjct: 377 ADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGG--QEQVREEVS 434
Query: 441 --TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
TE ++TI NL PY NV V+L+L NPEGRKE +E+ QTDED+P + ES+ +
Sbjct: 435 WDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGST 494
Query: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
E+ IFL+W EP + G+IT YEI+Y+++ S DP +++ +SKL NET+ +F L+
Sbjct: 495 FEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLY 554
Query: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGR 618
PGTTY F++RA T KGFG A + TT ISAPS ++ +PL +++NT+TV+L+PA R
Sbjct: 555 PGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614
Query: 619 GAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAM 678
GAP+SVYQ++VEEER RR ++ C+PVP+ F+ A +YF AE A SL A
Sbjct: 615 GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQ 674
Query: 679 PFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEV 738
PFT+GDN+TY G+WN PL P K+Y IYFQAAS GET+++C+++A K A P E
Sbjct: 675 PFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKPVP-EP 733
Query: 739 SQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYPKPVNMTKATV-NYRQ 797
++++ I G+ AG L +I+ LG ++V+ ++ K K T+ + RQ
Sbjct: 734 EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKR-----------KLAKKRKETMSSTRQ 782
Query: 798 EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRG--------------------- 836
E T M++++D+S+ +Q T ++ SFMDTH + R
Sbjct: 783 EMTVMVNSMDKSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNS 839
Query: 837 ---DQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYG 893
D+ ++ SSL+ + PY TGQLHPA+RVADLLQHI QMK AEGYG
Sbjct: 840 YYPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYG 899
Query: 894 FKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYI 949
FK+EYESFFEG WD+ KK + +R + AYD RV+L + GD N+DYIN NYI
Sbjct: 900 FKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYI 959
Query: 950 DGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTY 1009
DGYHR NH+IATQGP E +YDFWRMVW E+ +SI+M+T LVEVGRVKC +YWP+D++ Y
Sbjct: 960 DGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIY 1019
Query: 1010 GDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRR 1069
DIK+ L++TE LAEYV+RTFA+E+RG E+RQFHFT WP+HGVPYHATGLL F+R+
Sbjct: 1020 KDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQ 1079
Query: 1070 VKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQ 1129
VK+ +PP AGP+V+HCSAG GRTGC+IV+D+MLDMAE EGVVDIYNCV+ L SRRVNM+Q
Sbjct: 1080 VKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQ 1139
Query: 1130 TEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPP 1189
TEEQY+FIHDAILEACLCG+T++P S+ ++ Y +M ++DPQ+NSSQ++EEF+TLN VTP
Sbjct: 1140 TEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPT 1199
Query: 1190 LDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIV 1249
L VE+CSIALLPRN +KNR MD+LPPDRCLPFLI+ DG+S+NYINAAL DSY + +AFIV
Sbjct: 1200 LRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIV 1259
Query: 1250 TLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMS 1309
T HPL +T DFWRLV DY CTS+VMLN + + A C QYWPE G ++G ++VEF+S
Sbjct: 1260 TQHPLPNTVKDFWRLVLDYHCTSVVMLNDV---DPAQLCPQYWPENGVHRHGPIQVEFVS 1316
Query: 1310 GTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQA 1369
+ED+++R+FR+ N +R Q+G+ +V+ FQFL W YRDTP SK++FL L+ +VDKWQ
Sbjct: 1317 ADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQE 1376
Query: 1370 E--SGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMD 1427
E G+GRT+VHCLNGGGRSGTFCA + V EM+R VDVF A KTLRN KPNMV+ +D
Sbjct: 1377 EYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLD 1436
Query: 1428 QYHFCYDVALEYL 1440
QY FCY+VALEYL
Sbjct: 1437 QYKFCYEVALEYL 1449
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 1577 bits (4083), Expect = 0.0
Identities = 771/1466 (52%), Positives = 1018/1466 (69%), Gaps = 70/1466 (4%)
Query: 21 ETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHA 80
ET + GC F+E P C YSQ++ DDF WEQV + +P GS+++VN S
Sbjct: 21 ETFSGGCLFDE---PYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRP 77
Query: 81 PGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHG 140
GQRAH++ L ENDTHC+ F YF+ S+ PG L VYV+VN GPLG+ +WN++G
Sbjct: 78 EGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPT 137
Query: 141 RQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEV 200
R W++AELA+STFWPN YQV+FE + S +GY+ +D++ +L +PC + PHF R+ +VEV
Sbjct: 138 RTWNRAELAISTFWPNFYQVIFEVITS-GHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEV 196
Query: 201 NAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQD 260
NAGQ A+FQC A GR +R LQ P ++ S RRF+A+F + ++ +
Sbjct: 197 NAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAG 256
Query: 261 LYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRK 320
YRC+ + G G+SN+AEL+VKEPP PIAPPQL G TYL IQLN NSI GDGPIV +
Sbjct: 257 KYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAR 316
Query: 321 EIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKC 380
E+EY A G W + V +YK+ HLDPDTEYEISVLLTRPG+GGTG PGP L +RTKC
Sbjct: 317 EVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKC 376
Query: 381 AEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440
A+PMR P+ L E+++RQ+T++WEP GYNVTRCH+Y +++ Y Y +G + +RE V
Sbjct: 377 ADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQ--EQVREEVS 434
Query: 441 --TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
TE ++TI NL PY NV V+L+L NPEGRKE +E+ QTDED+P + ES+ +
Sbjct: 435 WDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGST 494
Query: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
E+ IFL+W EP + G+IT YEI+Y+++ S DP +++ +SKL NET+ +F L+
Sbjct: 495 FEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLY 554
Query: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGR 618
PGTTY F++RA T KGFG A + TT ISAPS ++ +PL +++NT+TV+L+PA R
Sbjct: 555 PGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614
Query: 619 GAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAM 678
GAP+SVYQ++VEEER RR ++ C+PVP+ F+ A +YF AE A SL A
Sbjct: 615 GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQ 674
Query: 679 PFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEV 738
PFT+GDN+TY G+WN PL P K+Y IYFQAAS GET+++C+++A K A P E
Sbjct: 675 PFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKPVP-EP 733
Query: 739 SQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYPKPVNMTKATVNY-RQ 797
++++ I G+ AG L +I+ LG ++V+ ++ K K T++ RQ
Sbjct: 734 EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKR-----------KLAKKRKETMSSTRQ 782
Query: 798 EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRG--------------------- 836
E T M++++D+S+ +Q T ++ SFMDTH + R
Sbjct: 783 EMTVMVNSMDKSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNS 839
Query: 837 ----------------DQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLL 880
D+ ++ SSL+ + PY TGQLHPA+RVADLL
Sbjct: 840 YYPDPFVPTAILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLL 899
Query: 881 QHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPML 936
QHI QMK AEGYGFK+EYESFFEG WD+ KK + +R + AYD RV+L +
Sbjct: 900 QHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIE 959
Query: 937 GDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRV 996
GD N+DYIN NYIDGYHR NH+IATQGP E +YDFWRMVW E+ +SI+M+T LVEVGRV
Sbjct: 960 GDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRV 1019
Query: 997 KCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGV 1056
KC +YWP+D++ Y DIK+ L++TE LAEYV+RTFA+E+RG E+RQFHFT WP+HGV
Sbjct: 1020 KCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGV 1079
Query: 1057 PYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNC 1116
PYHATGLL F+R+VK+ +PP AGP+V+HCSAG GRTGC+IV+D+MLDMAE EGVVDIYNC
Sbjct: 1080 PYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNC 1139
Query: 1117 VKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQL 1176
V+ L SRRVNM+QTEEQY+FIHDAILEACLCG+T++P S+ ++ Y +M ++DPQ+NSSQ+
Sbjct: 1140 VRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQI 1199
Query: 1177 REEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAA 1236
+EEF+TLN VTP L VE+CSIALLPRN +KNR MD+LPPDRCLPFLI+ DG+S+NYINAA
Sbjct: 1200 KEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAA 1259
Query: 1237 LTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPG 1296
L DSY + +AFIVT HPL +T DFWRLV DY CTS+VMLN + + A C QYWPE G
Sbjct: 1260 LMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV---DPAQLCPQYWPENG 1316
Query: 1297 RQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKA 1356
++G ++VEF+S +ED+++R+FR+ N +R Q+G+ +V+ FQFL W YRDTP SK++
Sbjct: 1317 VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRS 1376
Query: 1357 FLHLLAEVDKWQAE--SGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKT 1414
FL L+ +VDKWQ E G+GRT+VHCLNGGGRSGTFCA + V EM+R VDVF A KT
Sbjct: 1377 FLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKT 1436
Query: 1415 LRNYKPNMVETMDQYHFCYDVALEYL 1440
LRN KPNMV+ +DQY FCY+VALEYL
Sbjct: 1437 LRNNKPNMVDLLDQYKFCYEVALEYL 1462
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 1564 bits (4049), Expect = 0.0
Identities = 758/1452 (52%), Positives = 1019/1452 (70%), Gaps = 26/1452 (1%)
Query: 1 MARAQALVLALTFQLCAP-----ETETPAAGCTFEEASDPAVPCEYSQAQ-YDDFQWEQV 54
MA AL L+L +L P ++ A GC+F+E C YS A + F WEQ+
Sbjct: 1 MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSN---CGYSVALGTNGFTWEQI 57
Query: 55 RIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSP 114
+P GS++MVN+S A GQ+AH++ +L ENDTHC+ F Y+ SRD SP
Sbjct: 58 NTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSP 117
Query: 115 GTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYM 174
G L VYV+VNGGP G+ VWN++G W +AELA+STFWP+ YQV+FE++ GY+
Sbjct: 118 GALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYI 177
Query: 175 GLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPA 234
+D++ +L++PC KAPHF RL +VEVN GQNA+FQC+A G+ ++ ++ LQ+ +G
Sbjct: 178 AVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTAL 237
Query: 235 AGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQL 294
R ++HRRF AT +A ++ YRCV ++ G+GVSN+AELIVKEPPTPIAPP+L
Sbjct: 238 MVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPEL 297
Query: 295 LRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYE 354
L G TYL I+ N NSIIGDGPI+ KE+EYR G WAE H V YKLWHLDPD EYE
Sbjct: 298 LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357
Query: 355 ISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRC 414
I VLLTRPG+GGTG PGPPL +RTKCA+P+ P+ + +I+ARQLTLQWEP GY VTRC
Sbjct: 358 IRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRC 417
Query: 415 HTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEG 474
H+Y +++ Y Y NQ E + Q S YT++ L P+ + +RL+L+NPEGR E
Sbjct: 418 HSYNLTVQYQYVF----NQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMES 473
Query: 475 KEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAV 534
+E+ QT+EDVP + ES+ P E+ I+++W+ P E NG+IT YEI+Y+++ S DP+
Sbjct: 474 EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSA 533
Query: 535 NVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDY 594
++ R + KLRNET+H+F L+PGTTY F+++A T KGFG T I T ISAPS
Sbjct: 534 DLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPE 593
Query: 595 ADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFE 654
D +PL E++ TITV+L+PAQ RGAP+SVYQ++V+EER ++ RR +CF VP+++
Sbjct: 594 YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
Query: 655 AALARGLVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKG 714
A + +HYF AEL ++LP PFTVGDN+TY G+WNPPL P K+Y IYFQA S G
Sbjct: 654 NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713
Query: 715 ETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGR 774
ET++NC+R+A K A ++ +E ++ + + G+ AG L +I+LLG ++ I R+ R
Sbjct: 714 ETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRR-R 772
Query: 775 DHYAYSYYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYST 834
+ Y+YSYY K K T + Q + +++ D+ T S + DE S D +G++
Sbjct: 773 NAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFT- 831
Query: 835 RGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGF 894
D G +++ + + P R C Y Q PA+RVADLLQHI QMK +GYGF
Sbjct: 832 --DGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGF 889
Query: 895 KQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYID 950
K+EYE+ EG WD K+ + +R + +YD RV+L + GDP++DYINANYID
Sbjct: 890 KEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYID 949
Query: 951 GYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYG 1010
GYHR H+IATQGP E V DFWRM+WQE+ +SIVM+T LVEVGRVKC RYWP+D++ YG
Sbjct: 950 GYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYG 1009
Query: 1011 DIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRV 1070
DIK+ L++TE LAEYV+RTF ++++GY E+R FHFT+WP+HGVP +ATGLL F+R+V
Sbjct: 1010 DIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQV 1069
Query: 1071 KASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQT 1130
K PP+AGPIV+HCSAG GRTGC+I +D MLDMAE EGVVDI+NCV+ L ++RVN++QT
Sbjct: 1070 KFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQT 1129
Query: 1131 EEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPL 1190
EEQY+F+HDAILEACLCG T IPV EF++ Y + R+DPQ+NSSQ+++EFQTLN VTP +
Sbjct: 1130 EEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRV 1189
Query: 1191 DVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVT 1250
E+CSI LLPRN DKNRSMDVLP DRCLPFLIS DG+S+NYINAAL DS+ + AAF+VT
Sbjct: 1190 RPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVT 1249
Query: 1251 LHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSG 1310
HPL +T DFWRLV+DY C+S+VMLN++ ++A C+QYWPE YG ++VEF+S
Sbjct: 1250 QHPLPNTVADFWRLVFDYNCSSVVMLNEM---DTAQFCMQYWPEKTSGCYGPIQVEFVSA 1306
Query: 1311 TADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQA- 1369
DED++ R+FR+ N++R Q+G+ +V+H Q++ W AYRDTP SK++ L ++ ++KWQ
Sbjct: 1307 DIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQ 1366
Query: 1370 -ESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQ 1428
+ +GRT+VHCLNGGGRSGTFCA +V EMI+ N++DVF KTLRN K NMVET++Q
Sbjct: 1367 YDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQ 1426
Query: 1429 YHFCYDVALEYL 1440
Y F Y+VALEYL
Sbjct: 1427 YKFVYEVALEYL 1438
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 1554 bits (4023), Expect = 0.0
Identities = 759/1471 (51%), Positives = 1020/1471 (69%), Gaps = 45/1471 (3%)
Query: 1 MARAQALVLALTFQLCAP-----ETETPAAGCTFEEASDPAVPCEYSQAQ-YDDFQWEQV 54
MA AL L+L +L P ++ A GC+F+E C YS A + F WEQ+
Sbjct: 1 MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSN---CGYSVALGTNGFTWEQI 57
Query: 55 RIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSP 114
+P GS++MVN+S A GQ+AH++ +L ENDTHC+ F Y+ SRD SP
Sbjct: 58 NTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSP 117
Query: 115 GTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYM 174
G L VYV+VNGGP G+ VWN++G W +AELA+STFWP+ YQV+FE++ GY+
Sbjct: 118 GALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYI 177
Query: 175 GLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPA 234
+D++ +L++PC KAPHF RL +VEVN GQNA+FQC+A G+ ++ ++ LQ+ +G
Sbjct: 178 AVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTAL 237
Query: 235 AGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQL 294
R ++HRRF AT +A ++ YRCV ++ G+GVSN+AELIVKEPPTPIAPP+L
Sbjct: 238 MVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPEL 297
Query: 295 LRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYE 354
L G TYL I+ N NSIIGDGPI+ KE+EYR G WAE H V YKLWHLDPD EYE
Sbjct: 298 LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357
Query: 355 ISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRC 414
I VLLTRPG+GGTG PGPPL +RTKCA+P+ P+ + +I+ARQLTLQWEP GY VTRC
Sbjct: 358 IRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRC 417
Query: 415 HTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEG 474
H+Y +++ Y Y NQ E + Q S YT++ L P+ + +RL+L+NPEGR E
Sbjct: 418 HSYNLTVQYQYVF----NQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMES 473
Query: 475 KEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAV 534
+E+ QT+EDVP + ES+ P E+ I+++W+ P E NG+IT YEI+Y+++ S DP+
Sbjct: 474 EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSA 533
Query: 535 NVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDY 594
++ R + KLRNET+H+F L+PGTTY F+++A T KGFG T I T ISAPS
Sbjct: 534 DLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPE 593
Query: 595 ADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFE 654
D +PL E++ TITV+L+PAQ RGAP+SVYQ++V+EER ++ RR +CF VP+++
Sbjct: 594 YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
Query: 655 AALARGLVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKG 714
A + +HYF AEL ++LP PFTVGDN+TY G+WNPPL P K+Y IYFQA S G
Sbjct: 654 NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713
Query: 715 ETRLNCIRIARKA-------------------ACKESKRPLEVSQRSEEMGLILGICAGG 755
ET++NC+R+A KA A ++ +E ++ + + G+ AG
Sbjct: 714 ETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGL 773
Query: 756 LAVLILLLGAIIVIIRKGRDHYAYSYYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQST 815
L +I+LLG ++ I R+ R+ Y+YSYY K K T + Q + +++ D+ T S
Sbjct: 774 LMFIIILLGVMLTIKRR-RNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSA 832
Query: 816 LQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVR 875
+ DE S D +G++ D G +++ + + P R C Y Q PA+R
Sbjct: 833 SRNDEGFSSSSQDVNGFT---DGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIR 889
Query: 876 VADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVK 931
VADLLQHI QMK +GYGFK+EYE+ EG WD K+ + +R + +YD RV+
Sbjct: 890 VADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVR 949
Query: 932 LHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLV 991
L + GDP++DYINANYIDGYHR H+IATQGP E V DFWRM+WQE+ +SIVM+T LV
Sbjct: 950 LLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLV 1009
Query: 992 EVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAW 1051
EVGRVKC RYWP+D++ YGDIK+ L++TE LAEYV+RTF ++++GY E+R FHFT+W
Sbjct: 1010 EVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSW 1069
Query: 1052 PEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVV 1111
P+HGVP +ATGLL F+R+VK PP+AGPIV+HCSAG GRTGC+I +D MLDMAE EGVV
Sbjct: 1070 PDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVV 1129
Query: 1112 DIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQS 1171
DI+NCV+ L ++RVN++QTEEQY+F+HDAILEACLCG T IPV EF++ Y + R+DPQ+
Sbjct: 1130 DIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQT 1189
Query: 1172 NSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNN 1231
NSSQ+++EFQTLN VTP + E+CSI LLPRN DKNRSMDVLP DRCLPFLIS DG+S+N
Sbjct: 1190 NSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSN 1249
Query: 1232 YINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQY 1291
YINAAL DS+ + AAF+VT HPL +T DFWRLV+DY C+S+VMLN++ ++A C+QY
Sbjct: 1250 YINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM---DTAQFCMQY 1306
Query: 1292 WPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTP 1351
WPE YG ++VEF+S DED++ R+FR+ N++R Q+G+ +V+H Q++ W AYRDTP
Sbjct: 1307 WPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTP 1366
Query: 1352 DSKKAFLHLLAEVDKWQA--ESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVF 1409
SK++ L ++ ++KWQ + +GRT+VHCLNGGGRSGTFCA +V EMI+ N++DVF
Sbjct: 1367 PSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVF 1426
Query: 1410 FAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1440
KTLRN K NMVET++QY F Y+VALEYL
Sbjct: 1427 HIVKTLRNNKSNMVETLEQYKFVYEVALEYL 1457
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 462 bits (1188), Expect = e-129
Identities = 357/1144 (31%), Positives = 525/1144 (45%), Gaps = 146/1144 (12%)
Query: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
W + + Q + +L P Y + VL T GDG TG PG PL +
Sbjct: 463 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 520
Query: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
AEP + L W P R T L Y H + R
Sbjct: 521 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 558
Query: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
+ E G S Y ++ L P + RL +P+G G + + S A
Sbjct: 559 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGL--GASTAEISARTMQSMFAKNFHVKAV 615
Query: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
++ + L WE P+ N + ++I Y + V G T + NL
Sbjct: 616 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 662
Query: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
P +Y F + T +G L T +AP P+ +G++ + ITV L P
Sbjct: 663 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 717
Query: 617 GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
I Y +I+ ++ R + ++ + L E + R + Y G E+
Sbjct: 718 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 776
Query: 674 LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
A FT+GD++ Y GF N L+ + Y ++F A E+++
Sbjct: 777 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 835
Query: 728 ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYPKPVN 787
P ++ EE GLI + G + ++ ++ +I I+ Y KP
Sbjct: 836 VVSMDLDPQPITD--EEEGLIWVV--GPVLAVVFIICIVIAILL---------YKSKP-- 880
Query: 788 MTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEAS 847
DR + D R +
Sbjct: 881 -------------------DRKRAES-----------------------DSRKSSIPNNK 898
Query: 848 SLLGGSPRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG- 904
+ P P + + T + HP + + +L HI ++K + F QEYES G
Sbjct: 899 EIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ 958
Query: 905 ---WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIAT 961
W+ + + +R + AYD RV L + G P +DY+NANYIDGY + N +IAT
Sbjct: 959 QFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIAT 1018
Query: 962 QGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTE 1020
QG PE DFWRM+W++ +++VM+TKL E RVKC +YWP ++T+G +++ L+ T
Sbjct: 1019 QGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTV 1078
Query: 1021 TLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGP 1080
LA Y VRTFAL + G S + EVRQF FTAWP+HGVP H T LAF+RRVK PPDAGP
Sbjct: 1079 ELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGP 1138
Query: 1081 IVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA 1140
+V+HCSAG GRTGC+IV+D ML+ + E VDIY V + ++R M+QTE+QYIFIHDA
Sbjct: 1139 MVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDA 1198
Query: 1141 ILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALL 1200
+LEA CG T +P A +++ +I+ N + + EF+ L S A L
Sbjct: 1199 LLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SKAHTSRFISANL 1256
Query: 1201 PRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQST 1257
P N+ KNR ++++P + CL + +G ++YINA+ D Y + A+I T PL T
Sbjct: 1257 PCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKAYIATQGPLAET 1314
Query: 1258 TPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLV 1317
T DFWR+++++ T +VML +L + C QYWP +Y V+ M+ +
Sbjct: 1315 TEDFWRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1373
Query: 1318 ARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRT 1376
R F+V + Q VR FQF W + P S + F+ + +V K + + G DG
Sbjct: 1374 LREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1430
Query: 1377 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1436
VHC G GR+G F + VLE +R +VD+F K LR +P MV+T DQY F Y A
Sbjct: 1431 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAA 1490
Query: 1437 LEYL 1440
LEYL
Sbjct: 1491 LEYL 1494
Score = 62.8 bits (151), Expect = 2e-09
Identities = 76/342 (22%), Positives = 136/342 (39%), Gaps = 43/342 (12%)
Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Y CV+ + G + A++ VK P P P + + T + + ++ + P+
Sbjct: 297 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 352
Query: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
I+++ + E+ V+ Y + L P ++YE V+ + G G P P++++T
Sbjct: 353 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 410
Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
P AP+ + + + + +QW EP G YT+ H HN
Sbjct: 411 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 470
Query: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
+ TI NL+P + V+++ G + +D V +G+ +
Sbjct: 471 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 516
Query: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
L F E I L W P+ + I YE+ Y+ E G + I+ + T
Sbjct: 517 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 565
Query: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF 592
+ L P + Y F + AR+ +G G A+ EI+ F
Sbjct: 566 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSMF 606
Score = 62.4 bits (150), Expect = 3e-09
Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)
Query: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
E K GV+ RY++ L PY + R+V N GR E V QT E PS +
Sbjct: 362 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 421
Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
I ++W+EP+EPNG I Y + Y + DP +V + + +
Sbjct: 422 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 475
Query: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
NL P TY V A T G G ++ ++ T P PL E E+ +
Sbjct: 476 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 528
Query: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
+LL R I+ Y+++ E +R+ EPG
Sbjct: 529 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 564
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 461 bits (1185), Expect = e-129
Identities = 342/1088 (31%), Positives = 513/1088 (47%), Gaps = 133/1088 (12%)
Query: 383 PMRAPKGLAFAEIQARQLTLQWEP--LGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440
P P+ L + L W+P L R +YTV ++Q + +
Sbjct: 915 PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTV------VFRDINSQQELQNIT 968
Query: 441 TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLE 500
T+ +R+T+ L P +++ +G V A ++
Sbjct: 969 TD---TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1025
Query: 501 DMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPG 560
+ L WE P + ++I Y +V V G ++ KL ++L P
Sbjct: 1026 TSVLLSWEVPDSYKSAVP-FKILYNG-----QSVEVDG--HSMRKL-------IADLQPN 1070
Query: 561 TTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRG 619
T Y F + R G L I T AP + +P+ + + + Q
Sbjct: 1071 TEYSFVLMNRGSSAGGLQHLVSIRT---APDLLPHKPLPASAYIEDGRFDLSMPHVQDPS 1127
Query: 620 APISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAAL----------------ARGLVH 663
Y V+V +R P P L + L A L
Sbjct: 1128 LVRWFYIVVVPIDRVGGSMLTPRWST--PEELELDELLEAIEQGGEEQRRRRRQAERLKP 1185
Query: 664 YFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRI 723
Y A+L LPE FT+GD + YRGF+N PL P +Y + A+ + + R
Sbjct: 1186 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RY 1237
Query: 724 ARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYP 783
A E + +Q+ EE + L + LAV++++L I +++
Sbjct: 1238 ASSPYSDEIVVQVTPAQQQEEPEM-LWVTGPVLAVILIILIVIAILL------------- 1283
Query: 784 KPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGV 843
+++++TH S+ D ++ +GL
Sbjct: 1284 -----------FKRKRTHSPSSKD-----------EQSIGLK------------------ 1303
Query: 844 TEASSLLGGSPRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESF 901
SLL S P + Y T + HP + + DL +I ++K +G F QEYES
Sbjct: 1304 ---DSLLAHSSD-PVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESI 1359
Query: 902 FEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNH 957
G W+ + + +R + AYD RV L + G P +DYINANYIDGY + N
Sbjct: 1360 DPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNA 1419
Query: 958 FIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIML 1016
+IATQGP PE + DFWRMVW++ +++VM+T+L E RVKC +YWP ++T G I++ L
Sbjct: 1420 YIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTL 1479
Query: 1017 VKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPP 1076
+ T LA Y VRTFAL + G S + E+RQF F AWP+HGVP + T +LAF+RRVKA P
Sbjct: 1480 LDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPL 1539
Query: 1077 DAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIF 1136
DAGP+V+HCSAG GRTGC+IV+D ML+ + E VDIY V + S+R M+QTE+QY+F
Sbjct: 1540 DAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVF 1599
Query: 1137 IHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECS 1196
IH+A+LEA CG T +P A +++ ++ P + + + EF+ L S
Sbjct: 1600 IHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFI 1657
Query: 1197 IALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHP 1253
A LP N+ KNR ++++P + CL + +G ++YINA+ D Y + A+I T P
Sbjct: 1658 SANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEG--SDYINASFLDGYRQQKAYIATQGP 1715
Query: 1254 LQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTAD 1313
L +T DFWR+++++ T IVML +L + C QYWP +Y V+ M+
Sbjct: 1716 LAESTEDFWRMLWEHNSTIIVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNM 1774
Query: 1314 EDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG- 1372
+ R F+V + Q +R FQF W + P + + F+ + +V K + + G
Sbjct: 1775 PQYILREFKVTDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFIDFIGQVHKTKEQFGQ 1831
Query: 1373 DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFC 1432
DG VHC G GR+G F + VLE +R +VD+F KTLR +P MV+T DQY C
Sbjct: 1832 DGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLC 1891
Query: 1433 YDVALEYL 1440
Y ALEYL
Sbjct: 1892 YRAALEYL 1899
Score = 70.5 bits (171), Expect = 1e-11
Identities = 100/385 (25%), Positives = 149/385 (38%), Gaps = 31/385 (8%)
Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Y CV+ + G + A++ VK P P P L+ T + L +S + P+
Sbjct: 296 YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE-PVTYYG 351
Query: 322 IEYRMA--RGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
I+YR A GP+ EV V+ Y + L P +EY VL G G P + +RT
Sbjct: 352 IQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSEAVRARTG 409
Query: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECV 439
P P+ + + A + +QWEP Y V +YT S
Sbjct: 410 EQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV----YYTPDSRRPPNAWHKH 465
Query: 440 KTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
T+ G+ T+ +LLP +R L T + +T + VP+ A+
Sbjct: 466 NTDAGLLT-TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ-PADFQAEVE 523
Query: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
+ I L W P P I YE+ Y + E D V + + +L
Sbjct: 524 SDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKV--------TFDPTSSYTLEDLK 573
Query: 559 PGTTYLFSVRARTGKGFGQAALT-EITTNISAPSF-DYADMPSPLGESENTITVLLRPAQ 616
P T Y F + AR+ G G T E T S PS M +G + ++ + PA
Sbjct: 574 PDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPAD 633
Query: 617 GRGAPISVYQVIVE----EERARRL 637
R I+ Y V E E+R R +
Sbjct: 634 SRNGVITQYSVAYEAVDGEDRGRHV 658
Score = 60.5 bits (145), Expect = 1e-08
Identities = 65/260 (25%), Positives = 103/260 (39%), Gaps = 17/260 (6%)
Query: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400
+Y L L PDT Y L D G G P + +RT + P P+ + + + +
Sbjct: 566 SYTLEDLKPDTLYRFQ--LAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTV 623
Query: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460
+ W P + S+ Y G + + + + E S + + L +
Sbjct: 624 RVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREH--SSWDLVGLEKWTEYR 681
Query: 461 VRLVLTNPEGR-KEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEPQEPNG 515
V + G E V +TDEDVPSG + E L T + ++ K P + +G
Sbjct: 682 VWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVH--VYWKLPVPSKQHG 739
Query: 516 LITQYEISYQSIESSDP-----AVNVPGPRRTISKLRNETYH-VFSNLHPGTTYLFSVRA 569
I Y+++Y +E+ +P +V +E Y S L P TTY +V A
Sbjct: 740 QIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAA 799
Query: 570 RTGKGFGQAALTEITTNISA 589
T KG G + +I T A
Sbjct: 800 YTTKGDGARSKPKIVTTTGA 819
Score = 57.0 bits (136), Expect = 1e-07
Identities = 73/273 (26%), Positives = 104/273 (38%), Gaps = 47/273 (17%)
Query: 316 PIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLL-TRPGDGGTGRPGPPL 374
PI++ + +A W + +T + L P+T Y ++V T GDG +P
Sbjct: 760 PIIQ---DVMLAEAQWRPEESEDYET-TISGLTPETTYSVTVAAYTTKGDGARSKPK--- 812
Query: 375 ISRTKCAEPMRAPKGLAFAEIQARQLTLQWEP--------LGYNVTRCHTYTVSLCYHYT 426
I T A P R ++ + LQW P LGY + C
Sbjct: 813 IVTTTGAVPGRPTMMISTTAMNTA--LLQWHPPKELPGELLGYRLQYCRA---------- 860
Query: 427 LGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVP 486
+ TI + K +Q +T+ L RL N G E E +T ED+P
Sbjct: 861 -DEARPNTI-DFGKDDQ---HFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLP 915
Query: 487 SGIAAESLTFTPLEDMIF-LKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTI 543
SG ++L T L L W+ P E NG I Y + ++ I S N+
Sbjct: 916 SGFP-QNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNIT------ 968
Query: 544 SKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576
+T + L P TTY VRA T KG G
Sbjct: 969 ----TDTRFTLTGLKPDTTYDIKVRAWTSKGSG 997
Score = 50.1 bits (118), Expect = 2e-05
Identities = 54/200 (27%), Positives = 83/200 (41%), Gaps = 12/200 (6%)
Query: 446 SRYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAESLTFTPLEDMIF 504
+RY+I L P+ R++ N GR E V +T E PS +
Sbjct: 372 TRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTML 431
Query: 505 LKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYL 564
++WE P+EPNGL+ Y + Y P N T + L +L PG TY
Sbjct: 432 VQWEPPEEPNGLVRGYRVYYTPDSRRPP--NAWHKHNTDAGLLT----TVGSLLPGITYS 485
Query: 565 FSVRARTGKGFGQAALT-EITTNISAPSFDYADMPSPLGESENTITV--LLRPAQGRGAP 621
V A T G G + T ++ T P+ AD + + ES+ I + LL P +
Sbjct: 486 LRVLAFTAVGDGPPSPTIQVKTQQGVPA-QPADFQAEV-ESDTRIQLSWLLPPQERIIMY 543
Query: 622 ISVYQVIVEEERARRLRREP 641
VY +E++ ++ +P
Sbjct: 544 ELVYWAAEDEDQQHKVTFDP 563
Score = 48.9 bits (115), Expect = 4e-05
Identities = 79/360 (21%), Positives = 124/360 (34%), Gaps = 49/360 (13%)
Query: 261 LYRCVSQAPRGAGVSNFAELIVKEPP--TPIAPPQLLRA----GPTYLIIQLNTNSIIGD 314
LYR A GV F I TP APPQ + T + + + +
Sbjct: 577 LYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRN 636
Query: 315 GPIVRKEIEYRMARGPWAEVHAVS-----LQTYKLWHLDPDTEYEISVLLTRPGDGGTGR 369
G I + + Y G H V ++ L L+ TEY + V D G G
Sbjct: 637 GVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT--DVGPGP 694
Query: 370 PGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE-PL---------GYNVTRCHTYTV 419
P++ RT P P+ + + + + + W+ P+ GY VT
Sbjct: 695 ESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLEN- 753
Query: 420 SLCYHYTLGSSHNQTIRECVKTEQGVSR--------YTIKNLLPYRNVHVRLVLTNPEGR 471
G I + V + R TI L P V + +G
Sbjct: 754 --------GEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGD 805
Query: 472 KEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSD 531
+ T G ++ T + + L+W P+E G + Y + Y + +
Sbjct: 806 GARSKPKIVTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEAR 864
Query: 532 PAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591
P TI +++ + + LH GTTY+F + A+ G G+ EI T PS
Sbjct: 865 P--------NTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPS 916
Score = 32.3 bits (72), Expect = 3.4
Identities = 34/151 (22%), Positives = 62/151 (41%), Gaps = 11/151 (7%)
Query: 446 SRYTIKNLLPYRNVHVRLVLTNPEGRKE-GKEVTFQTDEDVPSGIAAESLTFTPLEDMIF 504
S YT+++L P +L + G + +T + PS + + + +
Sbjct: 565 SSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVR 624
Query: 505 LKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKL-RNETYHVFSNLHPGT 561
+ W P NG+ITQY ++Y++++ D R + + R + L T
Sbjct: 625 VSWVPPPADSRNGVITQYSVAYEAVDGEDRG------RHVVDGISREHSSWDLVGLEKWT 678
Query: 562 TYLFSVRARTGKGFG-QAALTEITTNISAPS 591
Y VRA T G G +++ + T+ PS
Sbjct: 679 EYRVWVRAHTDVGPGPESSPVLVRTDEDVPS 709
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 461 bits (1185), Expect = e-129
Identities = 342/1088 (31%), Positives = 513/1088 (47%), Gaps = 133/1088 (12%)
Query: 383 PMRAPKGLAFAEIQARQLTLQWEP--LGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440
P P+ L + L W+P L R +YTV ++Q + +
Sbjct: 906 PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTV------VFRDINSQQELQNIT 959
Query: 441 TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLE 500
T+ +R+T+ L P +++ +G V A ++
Sbjct: 960 TD---TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1016
Query: 501 DMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPG 560
+ L WE P + ++I Y +V V G ++ KL ++L P
Sbjct: 1017 TSVLLSWEVPDSYKSAVP-FKILYNG-----QSVEVDG--HSMRKL-------IADLQPN 1061
Query: 561 TTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYADMPSPLGESENTITVLLRPAQGRG 619
T Y F + R G L I T AP + +P+ + + + Q
Sbjct: 1062 TEYSFVLMNRGSSAGGLQHLVSIRT---APDLLPHKPLPASAYIEDGRFDLSMPHVQDPS 1118
Query: 620 APISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAAL----------------ARGLVH 663
Y V+V +R P P L + L A L
Sbjct: 1119 LVRWFYIVVVPIDRVGGSMLTPRWST--PEELELDELLEAIEQGGEEQRRRRRQAERLKP 1176
Query: 664 YFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRI 723
Y A+L LPE FT+GD + YRGF+N PL P +Y + A+ + + R
Sbjct: 1177 YVAAQLDV--LPET--FTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RY 1228
Query: 724 ARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYP 783
A E + +Q+ EE + L + LAV++++L I +++
Sbjct: 1229 ASSPYSDEIVVQVTPAQQQEEPEM-LWVTGPVLAVILIILIVIAILL------------- 1274
Query: 784 KPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGV 843
+++++TH S+ D ++ +GL
Sbjct: 1275 -----------FKRKRTHSPSSKD-----------EQSIGLK------------------ 1294
Query: 844 TEASSLLGGSPRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGFKQEYESF 901
SLL S P + Y T + HP + + DL +I ++K +G F QEYES
Sbjct: 1295 ---DSLLAHSSD-PVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESI 1350
Query: 902 FEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNH 957
G W+ + + +R + AYD RV L + G P +DYINANYIDGY + N
Sbjct: 1351 DPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNA 1410
Query: 958 FIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIML 1016
+IATQGP PE + DFWRMVW++ +++VM+T+L E RVKC +YWP ++T G I++ L
Sbjct: 1411 YIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTL 1470
Query: 1017 VKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPP 1076
+ T LA Y VRTFAL + G S + E+RQF F AWP+HGVP + T +LAF+RRVKA P
Sbjct: 1471 LDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPL 1530
Query: 1077 DAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIF 1136
DAGP+V+HCSAG GRTGC+IV+D ML+ + E VDIY V + S+R M+QTE+QY+F
Sbjct: 1531 DAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVF 1590
Query: 1137 IHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECS 1196
IH+A+LEA CG T +P A +++ ++ P + + + EF+ L S
Sbjct: 1591 IHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLAS--SKAHTSRFI 1648
Query: 1197 IALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHP 1253
A LP N+ KNR ++++P + CL + +G ++YINA+ D Y + A+I T P
Sbjct: 1649 SANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEG--SDYINASFLDGYRQQKAYIATQGP 1706
Query: 1254 LQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTAD 1313
L +T DFWR+++++ T IVML +L + C QYWP +Y V+ M+
Sbjct: 1707 LAESTEDFWRMLWEHNSTIIVMLTKLREMGRE-KCHQYWPAERSARYQYFVVDPMAEYNM 1765
Query: 1314 EDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESG- 1372
+ R F+V + Q +R FQF W + P + + F+ + +V K + + G
Sbjct: 1766 PQYILREFKVTDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFIDFIGQVHKTKEQFGQ 1822
Query: 1373 DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFC 1432
DG VHC G GR+G F + VLE +R +VD+F KTLR +P MV+T DQY C
Sbjct: 1823 DGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLC 1882
Query: 1433 YDVALEYL 1440
Y ALEYL
Sbjct: 1883 YRAALEYL 1890
Score = 70.5 bits (171), Expect = 1e-11
Identities = 100/385 (25%), Positives = 149/385 (38%), Gaps = 31/385 (8%)
Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Y CV+ + G + A++ VK P P P L+ T + L +S + P+
Sbjct: 296 YTCVAISSLGM-IEATAQVTVKALPKP--PIDLVVTETTATSVTLTWDSGNSE-PVTYYG 351
Query: 322 IEYRMA--RGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
I+YR A GP+ EV V+ Y + L P +EY VL G G P + +RT
Sbjct: 352 IQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAV--NSIGRGPPSEAVRARTG 409
Query: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECV 439
P P+ + + A + +QWEP Y V +YT S
Sbjct: 410 EQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV----YYTPDSRRPPNAWHKH 465
Query: 440 KTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
T+ G+ T+ +LLP +R L T + +T + VP+ A+
Sbjct: 466 NTDAGLLT-TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ-PADFQAEVE 523
Query: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
+ I L W P P I YE+ Y + E D V + + +L
Sbjct: 524 SDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKV--------TFDPTSSYTLEDLK 573
Query: 559 PGTTYLFSVRARTGKGFGQAALT-EITTNISAPSF-DYADMPSPLGESENTITVLLRPAQ 616
P T Y F + AR+ G G T E T S PS M +G + ++ + PA
Sbjct: 574 PDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPAD 633
Query: 617 GRGAPISVYQVIVE----EERARRL 637
R I+ Y V E E+R R +
Sbjct: 634 SRNGVITQYSVAYEAVDGEDRGRHV 658
Score = 56.2 bits (134), Expect = 2e-07
Identities = 68/242 (28%), Positives = 92/242 (38%), Gaps = 43/242 (17%)
Query: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405
L P+T Y ++V T GDG +P I T A P R ++ + LQW
Sbjct: 778 LTPETTYSVTVAAYTTKGDGARSKPK---IVTTTGAVPGRPTMMISTTAMNTA--LLQWH 832
Query: 406 P--------LGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYR 457
P LGY + C + TI + K +Q +T+ L
Sbjct: 833 PPKELPGELLGYRLQYCRA-----------DEARPNTI-DFGKDDQ---HFTVTGLHKGT 877
Query: 458 NVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIF-LKWEEP--QEPN 514
RL N G E E +T ED+PSG ++L T L L W+ P E N
Sbjct: 878 TYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFP-QNLHVTGLTTSTTELAWDPPVLAERN 936
Query: 515 GLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKG 574
G I Y + ++ I S N+ +T + L P TTY VRA T KG
Sbjct: 937 GRIISYTVVFRDINSQQELQNIT----------TDTRFTLTGLKPDTTYDIKVRAWTSKG 986
Query: 575 FG 576
G
Sbjct: 987 SG 988
Score = 51.6 bits (122), Expect = 5e-06
Identities = 78/352 (22%), Positives = 123/352 (34%), Gaps = 42/352 (11%)
Query: 261 LYRCVSQAPRGAGVSNFAELIVKEPP--TPIAPPQLLRA----GPTYLIIQLNTNSIIGD 314
LYR A GV F I TP APPQ + T + + + +
Sbjct: 577 LYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRN 636
Query: 315 GPIVRKEIEYRMARGPWAEVHAVS-----LQTYKLWHLDPDTEYEISVLLTRPGDGGTGR 369
G I + + Y G H V ++ L L+ TEY + V D G G
Sbjct: 637 GVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT--DVGPGP 694
Query: 370 PGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE-PL---------GYNVTRCHTYTV 419
P++ RT P P+ + + + + + W+ P+ GY VT
Sbjct: 695 ESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLEN- 753
Query: 420 SLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTF 479
G I + V + TI L P V + +G +
Sbjct: 754 --------GEPRGLPIIQDVMLAEA-QETTISGLTPETTYSVTVAAYTTKGDGARSKPKI 804
Query: 480 QTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGP 539
T G ++ T + + L+W P+E G + Y + Y + + P
Sbjct: 805 VTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARP------- 856
Query: 540 RRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591
TI +++ + + LH GTTY+F + A+ G G+ EI T PS
Sbjct: 857 -NTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPS 907
Score = 50.1 bits (118), Expect = 2e-05
Identities = 54/200 (27%), Positives = 83/200 (41%), Gaps = 12/200 (6%)
Query: 446 SRYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAESLTFTPLEDMIF 504
+RY+I L P+ R++ N GR E V +T E PS +
Sbjct: 372 TRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTML 431
Query: 505 LKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYL 564
++WE P+EPNGL+ Y + Y P N T + L +L PG TY
Sbjct: 432 VQWEPPEEPNGLVRGYRVYYTPDSRRPP--NAWHKHNTDAGLLT----TVGSLLPGITYS 485
Query: 565 FSVRARTGKGFGQAALT-EITTNISAPSFDYADMPSPLGESENTITV--LLRPAQGRGAP 621
V A T G G + T ++ T P+ AD + + ES+ I + LL P +
Sbjct: 486 LRVLAFTAVGDGPPSPTIQVKTQQGVPA-QPADFQAEV-ESDTRIQLSWLLPPQERIIMY 543
Query: 622 ISVYQVIVEEERARRLRREP 641
VY +E++ ++ +P
Sbjct: 544 ELVYWAAEDEDQQHKVTFDP 563
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 453 bits (1166), Expect = e-127
Identities = 327/992 (32%), Positives = 479/992 (48%), Gaps = 109/992 (10%)
Query: 478 TFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVP 537
TF D+ P + + ++ + L WE P N T Y+I Y + ++V
Sbjct: 1029 TFLRDQVSPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNGL-----TLDVD 1078
Query: 538 GPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYAD 596
G RT KL ++L P T Y F + T +G L + T +A + +
Sbjct: 1079 G--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTAWTAFNLLNGKP 1126
Query: 597 MPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAA 656
+P +++ I V L Q P+ Y +++ LR+ GGQ P+ +
Sbjct: 1127 SVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQFLTPLGSPEDMD 1180
Query: 657 LA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQTYRGFWNPPLEP 698
L R L H E+ S LP F GD + Y GF N LEP
Sbjct: 1181 LEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQYGGFDNRGLEP 1238
Query: 699 RKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAV 758
Y++ F A K E + ++ P + E + ++G LAV
Sbjct: 1239 GHRYVL-FVLAVLQKSEPTFAASPFSDPFQL-DNPDPQPIVDGEEGLIWVIGPV---LAV 1293
Query: 759 LILLLGAIIVIIRKGR-DHYAYSYYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQ 817
+ ++ I +++ K + D P+ TK +N H
Sbjct: 1294 VFIICIVIAILLYKNKPDSKRKDSEPR----TKCLLNNADLAPH---------------- 1333
Query: 818 EDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVA 877
H +R T S L R P G + + HP + +A
Sbjct: 1334 ------------HPKDPVEMRRINFQTPDSGL-----RSPLREPGFHFESMLSHPPIPIA 1376
Query: 878 DLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLH 933
D+ +H ++K + QEYES G W+ + + +R + AYD RV L
Sbjct: 1377 DMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQ 1436
Query: 934 PMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEV 993
P+ G +DYINANY+DGY N +IATQGP PE DFWRMVW++ ++IVM+T+L E
Sbjct: 1437 PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEK 1496
Query: 994 GRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWP 1052
R+KC +YWP ++TYG I++ L+ T LA + VRTF+L + G S + EVRQF FTAWP
Sbjct: 1497 SRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWP 1556
Query: 1053 EHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVD 1112
+HGVP + T LAF+RRVK PPDAGPIV+HCSAG GRTGC+IV+D ML+ + E VD
Sbjct: 1557 DHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVD 1616
Query: 1113 IYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSN 1172
+Y V + S+R M+QTE+QY FIH+A+LEA CG T +P A +++ +++P +
Sbjct: 1617 VYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEH 1676
Query: 1173 SSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDS 1229
+ + EF+ L A LP N+ KNR ++++P + CL + +G
Sbjct: 1677 VTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG-- 1732
Query: 1230 NNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCL 1289
++YINA+ D Y + A+I T PL TT DFWR++++ T +VML +L + C
Sbjct: 1733 SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGRE-KCH 1791
Query: 1290 QYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRD 1349
QYWP +Y V+ M+ + R F+V + Q VR FQF W +
Sbjct: 1792 QYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QG 1848
Query: 1350 TPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDV 1408
P S + F+ + +V K + + G DG VHC G GR+G F + VLE +R +VD+
Sbjct: 1849 VPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDI 1908
Query: 1409 FFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1440
F K LR +P MV+T D+Y FCY ALEYL
Sbjct: 1909 FQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1940
Score = 63.5 bits (153), Expect = 1e-09
Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)
Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Y CV+ + G + A++ VK P P + T + I ++ + P+
Sbjct: 309 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 364
Query: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
IEY+ GP+ ++ Y + L P++EYEI V + G G P +++RT
Sbjct: 365 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 422
Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437
P AP+ + + A + +QW EP+ N + R + ++ + +G+ + +
Sbjct: 423 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 482
Query: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493
+ T T+ +LL VR L T+ + +T + VP + AE+
Sbjct: 483 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 535
Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
+ E I L W P++ + I +YE+ ++ + P T +V
Sbjct: 536 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 580
Query: 554 FSNLHPGTTYLFSVRARTGKGFG 576
+L P T Y F + AR+ +G G
Sbjct: 581 VEDLKPNTEYAFRLAARSPQGLG 603
Score = 50.8 bits (120), Expect = 9e-06
Identities = 66/270 (24%), Positives = 102/270 (37%), Gaps = 37/270 (13%)
Query: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400
+Y + L P+TEY + P G G P + RT ++P P+ + +++ +
Sbjct: 578 SYVVEDLKPNTEYAFRLAARSPQ--GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAI 635
Query: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLP----- 455
+ W P S+ Y LGS + K G+ T + LL
Sbjct: 636 LVSWRPPPPETHNGALVGYSVRYR-PLGSEDPEP-----KEVNGIPPTTTQILLEALEKW 689
Query: 456 --YRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEE 509
YR V P E V +TDEDVPS + AE+L T + + +
Sbjct: 690 TQYRITTVAHTEVGPG--PESSPVVVRTDEDVPSAPPRKVEAEALNATAIR--VLWRSPA 745
Query: 510 PQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKL----------RNETYHVFSNLHP 559
P +G I Y++ Y +E ++ GP R + E V +NL P
Sbjct: 746 PGRQHGQIRGYQVHYVRMEGAEAR----GPPRIKDVMLADAQWETDDTAEYEMVITNLQP 801
Query: 560 GTTYLFSVRARTGKGFGQAALTEITTNISA 589
T Y +V A T KG G + ++ A
Sbjct: 802 ETAYSITVAAYTMKGDGARSKPKVVVTKGA 831
Score = 39.7 bits (91), Expect = 0.021
Identities = 55/244 (22%), Positives = 80/244 (32%), Gaps = 35/244 (14%)
Query: 346 HLDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEP----MRAPKGLAFAEIQARQL 400
+L P+T Y I+V T GDG +P + P + P+G A +
Sbjct: 798 NLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAG 857
Query: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460
T + + LGY + + T ++ RYT +
Sbjct: 858 TAEDQVLGYRLQF---------------GREDSTPLATLEFPPSEDRYTASGVHKGATYV 902
Query: 461 VRLVLTNPEGRKEGKEVTFQTDEDVPSG------IAAESLTFTPLEDMIFLKW--EEPQE 512
RL + G E ED P G A + T + L+W P E
Sbjct: 903 FRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGT-----VLLRWLPPVPAE 957
Query: 513 PNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTG 572
NG I +Y ++ + + PA P N L P T Y VRA T
Sbjct: 958 RNGAIVKYTVAVREAGALGPARETELPAAAEPGAENAL--TLQGLKPDTAYDLQVRAHTR 1015
Query: 573 KGFG 576
+G G
Sbjct: 1016 RGPG 1019
Score = 37.4 bits (85), Expect = 0.11
Identities = 85/412 (20%), Positives = 152/412 (36%), Gaps = 56/412 (13%)
Query: 262 YRCVSQAPRGAGVSNFAELIVKEP--PTPIAPPQLLRA---GPTYLII-------QLNTN 309
+R +++P+G G F ++ + P APPQ ++ T +++ + +
Sbjct: 592 FRLAARSPQGLGA--FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNG 649
Query: 310 SIIGDG----PIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDG 365
+++G P+ ++ E + G + L+ + W T+Y I+ + +
Sbjct: 650 ALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKW-----TQYRITTVAHT--EV 702
Query: 366 GTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPL--GYNVTRCHTYTVSLCY 423
G G P++ RT P P+ + + A + + W G + Y V
Sbjct: 703 GPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVR 762
Query: 424 HYTLGSSHNQTIRECVKTE-----QGVSRY--TIKNLLPYRNVHVRLVLTNPEGRKEGKE 476
+ I++ + + + Y I NL P + + +G +
Sbjct: 763 MEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSK 822
Query: 477 VTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQ-EPNGLITQYEISYQSIESSDPAVN 535
+ G S+ TP E + +WE P + Y + + +S+
Sbjct: 823 PKVVVTKGAVLGRPTLSVQQTP-EGSLLARWEPPAGTAEDQVLGYRLQFGREDST----- 876
Query: 536 VPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYA 595
P T+ +E + S +H G TY+F + AR+ G G+ E +S P
Sbjct: 877 ---PLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGE----EAAEVLSIPEDTPR 929
Query: 596 DMPSPLGESENTI--TVLLR-----PAQGRGAPISVYQVIVEEERARRLRRE 640
P L + N TVLLR PA+ GA I Y V V E A RE
Sbjct: 930 GHPQILEAAGNASAGTVLLRWLPPVPAERNGA-IVKYTVAVREAGALGPARE 980
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 449 bits (1156), Expect = e-126
Identities = 249/615 (40%), Positives = 351/615 (57%), Gaps = 19/615 (3%)
Query: 837 DQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGF 894
D R + + P P + + T + HP + + +L HI ++K + F
Sbjct: 1298 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 1357
Query: 895 KQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYID 950
QEYES G W+ + + +R + AYD RV L + G P +DY+NANYID
Sbjct: 1358 SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID 1417
Query: 951 GYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTY 1009
GY + N +IATQG PE DFWRM+W++ +++VM+TKL E RVKC +YWP ++T+
Sbjct: 1418 GYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH 1477
Query: 1010 GDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRR 1069
G +++ L+ T LA Y VRTFAL + G S + EVRQF FTAWP+HGVP H T LAF+RR
Sbjct: 1478 GLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRR 1537
Query: 1070 VKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQ 1129
VK PPDAGP+V+HCSAG GRTGC+IV+D ML+ + E VDIY V + ++R M+Q
Sbjct: 1538 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1597
Query: 1130 TEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPP 1189
TE+QYIFIHDA+LEA CG T +P A +++ +I+ N + + EF+ L S
Sbjct: 1598 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SK 1655
Query: 1190 LDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAA 1246
A LP N+ KNR ++++P + CL + +G ++YINA+ D Y + A
Sbjct: 1656 AHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKA 1713
Query: 1247 FIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVE 1306
+I T PL TT DFWR+++++ T +VML +L + C QYWP +Y V+
Sbjct: 1714 YIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVD 1772
Query: 1307 FMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDK 1366
M+ + R F+V + Q VR FQF W + P S + F+ + +V K
Sbjct: 1773 PMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHK 1829
Query: 1367 WQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVET 1425
+ + G DG VHC G GR+G F + VLE +R +VD+F K LR +P MV+T
Sbjct: 1830 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1889
Query: 1426 MDQYHFCYDVALEYL 1440
DQY F Y ALEYL
Sbjct: 1890 EDQYQFSYRAALEYL 1904
Score = 63.9 bits (154), Expect = 1e-09
Identities = 85/366 (23%), Positives = 148/366 (40%), Gaps = 46/366 (12%)
Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Y CV+ + G + A++ VK P P P + + T + + ++ + P+
Sbjct: 300 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 355
Query: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
I+++ + E+ V+ Y + L P ++YE V+ + G G P P++++T
Sbjct: 356 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 413
Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
P AP+ + + + + +QW EP G YT+ H HN
Sbjct: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473
Query: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
+ TI NL+P + V+++ G + +D V +G+ +
Sbjct: 474 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 519
Query: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
L F E I L W P+ + I YE+ Y+ E G + I+ + T
Sbjct: 520 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 568
Query: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEIT--TNISAPSFDYADMPSPLGESENTI 608
+ L P + Y F + AR+ +G G A+ EI+ T S PS D+ S S +I
Sbjct: 569 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSKPSAPPQDI-SCTSPSSTSI 626
Query: 609 TVLLRP 614
V +P
Sbjct: 627 LVSWQP 632
Score = 62.4 bits (150), Expect = 3e-09
Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)
Query: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
E K GV+ RY++ L PY + R+V N GR E V QT E PS +
Sbjct: 365 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 424
Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
I ++W+EP+EPNG I Y + Y + DP +V + + +
Sbjct: 425 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 478
Query: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
NL P TY V A T G G ++ ++ T P PL E E+ +
Sbjct: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 531
Query: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
+LL R I+ Y+++ E +R+ EPG
Sbjct: 532 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 567
Score = 59.7 bits (143), Expect = 2e-08
Identities = 71/277 (25%), Positives = 107/277 (38%), Gaps = 46/277 (16%)
Query: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
W + + Q + +L P Y + VL T GDG TG PG PL +
Sbjct: 466 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 523
Query: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
AEP + L W P R T L Y H + R
Sbjct: 524 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 561
Query: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGK-EVTFQTDEDVPSGIAAESLTFT 497
+ E G S Y ++ L P + RL +P+G E++ +T + PS + +
Sbjct: 562 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 620
Query: 498 PLEDMIFLKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFS 555
P I + W+ P ++ NG+IT+Y I Y +++ D P + + T ++
Sbjct: 621 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDK-----PHEILGIPSDTTKYLLE 675
Query: 556 NLHPGTTYLFSVRARTGKGFGQAALTE-ITTNISAPS 591
L T Y +V A T G G +L+ I TN PS
Sbjct: 676 QLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPS 712
Score = 54.7 bits (130), Expect = 6e-07
Identities = 55/262 (20%), Positives = 107/262 (40%), Gaps = 21/262 (8%)
Query: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400
+Y+L L P++ Y + P G G + +RT ++P P+ ++ + +
Sbjct: 569 SYRLQGLKPNSLYYFRLAARSPQ--GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSI 626
Query: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460
+ W+P V + + YT + E + ++Y ++ L +
Sbjct: 627 LVSWQPPP--VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYR 684
Query: 461 VRLVLTNPEGR-KEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP--QEP 513
+ + G E V +T+EDVPSG + E++ T ++ + W P +
Sbjct: 685 ITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVK----VSWRSPVPNKQ 740
Query: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNE----TYH--VFSNLHPGTTYLFSV 567
+G I Y++ Y +E+ +P ++ + E T H + S L P T+Y +V
Sbjct: 741 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTV 800
Query: 568 RARTGKGFGQAALTEITTNISA 589
A T KG G + ++ + A
Sbjct: 801 TAYTTKGDGARSKPKLVSTTGA 822
Score = 52.0 bits (123), Expect = 4e-06
Identities = 59/233 (25%), Positives = 86/233 (36%), Gaps = 22/233 (9%)
Query: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405
L P+T Y ++V T GDG R P L+S T L Q +QW
Sbjct: 790 LQPETSYSLTVTAYTTKGDGA--RSKPKLVSTTGAVP---GKPRLVINHTQMNTALIQWH 844
Query: 406 PLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVL 465
P T+ Y G + + +E+ +T ++ + RL
Sbjct: 845 P------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKE-DHFTATDIHKGASYVFRLSA 897
Query: 466 TNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEP--QEPNGLITQYEIS 523
N G E E+VP+G + + L W+ P E NG+IT+Y +
Sbjct: 898 RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLL 957
Query: 524 YQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576
Y+ I N+P + +T + L P TTY VRA T KG G
Sbjct: 958 YRDI-------NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG 1003
Score = 43.9 bits (102), Expect = 0.001
Identities = 68/351 (19%), Positives = 127/351 (36%), Gaps = 35/351 (9%)
Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPT-PIAPPQLLRA---GPTYLIIQLNTNSIIG-DGP 316
+R +++P+G G S AE+ + + P APPQ + T +++ + +G
Sbjct: 583 FRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 641
Query: 317 IVRKEIEYRMARGPWAEVHAV-----SLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPG 371
I I+Y G + H + Y L L+ TEY I+V T D G G
Sbjct: 642 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPES 699
Query: 372 PPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTL---G 428
++ RT P P+ + + + + + W N + H HY G
Sbjct: 700 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN--KQHGQIRGYQVHYVRMENG 757
Query: 429 SSHNQTIRECVKTEQGVSRYT--------IKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480
Q + + V + I L P + + + +G +
Sbjct: 758 EPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLV 817
Query: 481 TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540
+ G + T + + ++W P + G + Y + + + P
Sbjct: 818 STTGAVPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDME--------PL 868
Query: 541 RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591
T+ E + +++H G +Y+F + AR GFG+ + EI+ P+
Sbjct: 869 TTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 919
Score = 31.6 bits (70), Expect = 5.8
Identities = 63/285 (22%), Positives = 111/285 (38%), Gaps = 34/285 (11%)
Query: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
++ + L WE P+ N + ++I Y + V G T + NL
Sbjct: 1030 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 1076
Query: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
P +Y F + T +G L T +AP P+ +G++ + ITV L P
Sbjct: 1077 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 1131
Query: 617 GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
I Y +I+ ++ R + ++ + L E + R + Y G E+
Sbjct: 1132 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 1190
Query: 674 LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
A FT+GD++ Y GF N L+ + Y ++F A E+++
Sbjct: 1191 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 1249
Query: 728 ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRK 772
P ++ EE GLI + LAV+ ++ I +++ K
Sbjct: 1250 VVSMDLDPQPIT--DEEEGLI-WVVGPVLAVVFIICIVIAILLYK 1291
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 449 bits (1156), Expect = e-126
Identities = 249/615 (40%), Positives = 351/615 (57%), Gaps = 19/615 (3%)
Query: 837 DQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGF 894
D R + + P P + + T + HP + + +L HI ++K + F
Sbjct: 1285 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 1344
Query: 895 KQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYID 950
QEYES G W+ + + +R + AYD RV L + G P +DY+NANYID
Sbjct: 1345 SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID 1404
Query: 951 GYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTY 1009
GY + N +IATQG PE DFWRM+W++ +++VM+TKL E RVKC +YWP ++T+
Sbjct: 1405 GYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH 1464
Query: 1010 GDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRR 1069
G +++ L+ T LA Y VRTFAL + G S + EVRQF FTAWP+HGVP H T LAF+RR
Sbjct: 1465 GLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRR 1524
Query: 1070 VKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQ 1129
VK PPDAGP+V+HCSAG GRTGC+IV+D ML+ + E VDIY V + ++R M+Q
Sbjct: 1525 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1584
Query: 1130 TEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPP 1189
TE+QYIFIHDA+LEA CG T +P A +++ +I+ N + + EF+ L S
Sbjct: 1585 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SK 1642
Query: 1190 LDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAA 1246
A LP N+ KNR ++++P + CL + +G ++YINA+ D Y + A
Sbjct: 1643 AHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKA 1700
Query: 1247 FIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVE 1306
+I T PL TT DFWR+++++ T +VML +L + C QYWP +Y V+
Sbjct: 1701 YIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVD 1759
Query: 1307 FMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDK 1366
M+ + R F+V + Q VR FQF W + P S + F+ + +V K
Sbjct: 1760 PMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHK 1816
Query: 1367 WQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVET 1425
+ + G DG VHC G GR+G F + VLE +R +VD+F K LR +P MV+T
Sbjct: 1817 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1876
Query: 1426 MDQYHFCYDVALEYL 1440
DQY F Y ALEYL
Sbjct: 1877 EDQYQFSYRAALEYL 1891
Score = 63.9 bits (154), Expect = 1e-09
Identities = 85/366 (23%), Positives = 148/366 (40%), Gaps = 46/366 (12%)
Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Y CV+ + G + A++ VK P P P + + T + + ++ + P+
Sbjct: 287 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 342
Query: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
I+++ + E+ V+ Y + L P ++YE V+ + G G P P++++T
Sbjct: 343 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 400
Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
P AP+ + + + + +QW EP G YT+ H HN
Sbjct: 401 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 460
Query: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
+ TI NL+P + V+++ G + +D V +G+ +
Sbjct: 461 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 506
Query: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
L F E I L W P+ + I YE+ Y+ E G + I+ + T
Sbjct: 507 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 555
Query: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEIT--TNISAPSFDYADMPSPLGESENTI 608
+ L P + Y F + AR+ +G G A+ EI+ T S PS D+ S S +I
Sbjct: 556 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSKPSAPPQDI-SCTSPSSTSI 613
Query: 609 TVLLRP 614
V +P
Sbjct: 614 LVSWQP 619
Score = 62.4 bits (150), Expect = 3e-09
Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)
Query: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
E K GV+ RY++ L PY + R+V N GR E V QT E PS +
Sbjct: 352 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 411
Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
I ++W+EP+EPNG I Y + Y + DP +V + + +
Sbjct: 412 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 465
Query: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
NL P TY V A T G G ++ ++ T P PL E E+ +
Sbjct: 466 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 518
Query: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
+LL R I+ Y+++ E +R+ EPG
Sbjct: 519 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 554
Score = 59.7 bits (143), Expect = 2e-08
Identities = 71/277 (25%), Positives = 107/277 (38%), Gaps = 46/277 (16%)
Query: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
W + + Q + +L P Y + VL T GDG TG PG PL +
Sbjct: 453 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 510
Query: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
AEP + L W P R T L Y H + R
Sbjct: 511 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 548
Query: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGK-EVTFQTDEDVPSGIAAESLTFT 497
+ E G S Y ++ L P + RL +P+G E++ +T + PS + +
Sbjct: 549 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 607
Query: 498 PLEDMIFLKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFS 555
P I + W+ P ++ NG+IT+Y I Y +++ D P + + T ++
Sbjct: 608 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDK-----PHEILGIPSDTTKYLLE 662
Query: 556 NLHPGTTYLFSVRARTGKGFGQAALTE-ITTNISAPS 591
L T Y +V A T G G +L+ I TN PS
Sbjct: 663 QLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPS 699
Score = 54.7 bits (130), Expect = 6e-07
Identities = 55/262 (20%), Positives = 107/262 (40%), Gaps = 21/262 (8%)
Query: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400
+Y+L L P++ Y + P G G + +RT ++P P+ ++ + +
Sbjct: 556 SYRLQGLKPNSLYYFRLAARSPQ--GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSI 613
Query: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460
+ W+P V + + YT + E + ++Y ++ L +
Sbjct: 614 LVSWQPPP--VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYR 671
Query: 461 VRLVLTNPEGR-KEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP--QEP 513
+ + G E V +T+EDVPSG + E++ T ++ + W P +
Sbjct: 672 ITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVK----VSWRSPVPNKQ 727
Query: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNE----TYH--VFSNLHPGTTYLFSV 567
+G I Y++ Y +E+ +P ++ + E T H + S L P T+Y +V
Sbjct: 728 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTV 787
Query: 568 RARTGKGFGQAALTEITTNISA 589
A T KG G + ++ + A
Sbjct: 788 TAYTTKGDGARSKPKLVSTTGA 809
Score = 52.0 bits (123), Expect = 4e-06
Identities = 59/233 (25%), Positives = 86/233 (36%), Gaps = 22/233 (9%)
Query: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405
L P+T Y ++V T GDG R P L+S T L Q +QW
Sbjct: 777 LQPETSYSLTVTAYTTKGDGA--RSKPKLVSTTGAVP---GKPRLVINHTQMNTALIQWH 831
Query: 406 PLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVL 465
P T+ Y G + + +E+ +T ++ + RL
Sbjct: 832 P------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKE-DHFTATDIHKGASYVFRLSA 884
Query: 466 TNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEP--QEPNGLITQYEIS 523
N G E E+VP+G + + L W+ P E NG+IT+Y +
Sbjct: 885 RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLL 944
Query: 524 YQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576
Y+ I N+P + +T + L P TTY VRA T KG G
Sbjct: 945 YRDI-------NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG 990
Score = 43.9 bits (102), Expect = 0.001
Identities = 68/351 (19%), Positives = 127/351 (36%), Gaps = 35/351 (9%)
Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPT-PIAPPQLLRA---GPTYLIIQLNTNSIIG-DGP 316
+R +++P+G G S AE+ + + P APPQ + T +++ + +G
Sbjct: 570 FRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 628
Query: 317 IVRKEIEYRMARGPWAEVHAV-----SLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPG 371
I I+Y G + H + Y L L+ TEY I+V T D G G
Sbjct: 629 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPES 686
Query: 372 PPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTL---G 428
++ RT P P+ + + + + + W N + H HY G
Sbjct: 687 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN--KQHGQIRGYQVHYVRMENG 744
Query: 429 SSHNQTIRECVKTEQGVSRYT--------IKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ 480
Q + + V + I L P + + + +G +
Sbjct: 745 EPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLV 804
Query: 481 TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR 540
+ G + T + + ++W P + G + Y + + + P
Sbjct: 805 STTGAVPGKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDME--------PL 855
Query: 541 RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591
T+ E + +++H G +Y+F + AR GFG+ + EI+ P+
Sbjct: 856 TTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 906
Score = 31.6 bits (70), Expect = 5.8
Identities = 63/285 (22%), Positives = 111/285 (38%), Gaps = 34/285 (11%)
Query: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
++ + L WE P+ N + ++I Y + V G T + NL
Sbjct: 1017 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 1063
Query: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
P +Y F + T +G L T +AP P+ +G++ + ITV L P
Sbjct: 1064 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 1118
Query: 617 GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
I Y +I+ ++ R + ++ + L E + R + Y G E+
Sbjct: 1119 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 1177
Query: 674 LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
A FT+GD++ Y GF N L+ + Y ++F A E+++
Sbjct: 1178 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 1236
Query: 728 ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRK 772
P ++ EE GLI + LAV+ ++ I +++ K
Sbjct: 1237 VVSMDLDPQPIT--DEEEGLI-WVVGPVLAVVFIICIVIAILLYK 1278
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 449 bits (1156), Expect = e-126
Identities = 249/615 (40%), Positives = 351/615 (57%), Gaps = 19/615 (3%)
Query: 837 DQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGF 894
D R + + P P + + T + HP + + +L HI ++K + F
Sbjct: 1289 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 1348
Query: 895 KQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYID 950
QEYES G W+ + + +R + AYD RV L + G P +DY+NANYID
Sbjct: 1349 SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID 1408
Query: 951 GYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTY 1009
GY + N +IATQG PE DFWRM+W++ +++VM+TKL E RVKC +YWP ++T+
Sbjct: 1409 GYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH 1468
Query: 1010 GDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRR 1069
G +++ L+ T LA Y VRTFAL + G S + EVRQF FTAWP+HGVP H T LAF+RR
Sbjct: 1469 GLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRR 1528
Query: 1070 VKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQ 1129
VK PPDAGP+V+HCSAG GRTGC+IV+D ML+ + E VDIY V + ++R M+Q
Sbjct: 1529 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1588
Query: 1130 TEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPP 1189
TE+QYIFIHDA+LEA CG T +P A +++ +I+ N + + EF+ L S
Sbjct: 1589 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SK 1646
Query: 1190 LDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAA 1246
A LP N+ KNR ++++P + CL + +G ++YINA+ D Y + A
Sbjct: 1647 AHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKA 1704
Query: 1247 FIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVE 1306
+I T PL TT DFWR+++++ T +VML +L + C QYWP +Y V+
Sbjct: 1705 YIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVD 1763
Query: 1307 FMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDK 1366
M+ + R F+V + Q VR FQF W + P S + F+ + +V K
Sbjct: 1764 PMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHK 1820
Query: 1367 WQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVET 1425
+ + G DG VHC G GR+G F + VLE +R +VD+F K LR +P MV+T
Sbjct: 1821 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1880
Query: 1426 MDQYHFCYDVALEYL 1440
DQY F Y ALEYL
Sbjct: 1881 EDQYQFSYRAALEYL 1895
Score = 63.9 bits (154), Expect = 1e-09
Identities = 85/366 (23%), Positives = 148/366 (40%), Gaps = 46/366 (12%)
Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Y CV+ + G + A++ VK P P P + + T + + ++ + P+
Sbjct: 300 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 355
Query: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
I+++ + E+ V+ Y + L P ++YE V+ + G G P P++++T
Sbjct: 356 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 413
Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
P AP+ + + + + +QW EP G YT+ H HN
Sbjct: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473
Query: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
+ TI NL+P + V+++ G + +D V +G+ +
Sbjct: 474 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 519
Query: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
L F E I L W P+ + I YE+ Y+ E G + I+ + T
Sbjct: 520 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 568
Query: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEIT--TNISAPSFDYADMPSPLGESENTI 608
+ L P + Y F + AR+ +G G A+ EI+ T S PS D+ S S +I
Sbjct: 569 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSKPSAPPQDI-SCTSPSSTSI 626
Query: 609 TVLLRP 614
V +P
Sbjct: 627 LVSWQP 632
Score = 62.4 bits (150), Expect = 3e-09
Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)
Query: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
E K GV+ RY++ L PY + R+V N GR E V QT E PS +
Sbjct: 365 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 424
Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
I ++W+EP+EPNG I Y + Y + DP +V + + +
Sbjct: 425 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 478
Query: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
NL P TY V A T G G ++ ++ T P PL E E+ +
Sbjct: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 531
Query: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
+LL R I+ Y+++ E +R+ EPG
Sbjct: 532 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 567
Score = 59.7 bits (143), Expect = 2e-08
Identities = 71/277 (25%), Positives = 107/277 (38%), Gaps = 46/277 (16%)
Query: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
W + + Q + +L P Y + VL T GDG TG PG PL +
Sbjct: 466 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 523
Query: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
AEP + L W P R T L Y H + R
Sbjct: 524 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 561
Query: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGK-EVTFQTDEDVPSGIAAESLTFT 497
+ E G S Y ++ L P + RL +P+G E++ +T + PS + +
Sbjct: 562 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 620
Query: 498 PLEDMIFLKWEEP--QEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFS 555
P I + W+ P ++ NG+IT+Y I Y +++ D P + + T ++
Sbjct: 621 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDK-----PHEILGIPSDTTKYLLE 675
Query: 556 NLHPGTTYLFSVRARTGKGFGQAALTE-ITTNISAPS 591
L T Y +V A T G G +L+ I TN PS
Sbjct: 676 QLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPS 712
Score = 58.2 bits (139), Expect = 6e-08
Identities = 54/256 (21%), Positives = 104/256 (40%), Gaps = 18/256 (7%)
Query: 341 TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQL 400
+Y+L L P++ Y + P G G + +RT ++P P+ ++ + +
Sbjct: 569 SYRLQGLKPNSLYYFRLAARSPQ--GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSI 626
Query: 401 TLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVH 460
+ W+P V + + YT + E + ++Y ++ L +
Sbjct: 627 LVSWQPPP--VEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYR 684
Query: 461 VRLVLTNPEGR-KEGKEVTFQTDEDVPSG----IAAESLTFTPLEDMIFLKWEEP--QEP 513
+ + G E V +T+EDVPSG + E++ T ++ + W P +
Sbjct: 685 ITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVK----VSWRSPVPNKQ 740
Query: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGK 573
+G I Y++ Y +E+ +P P L + + S L P T+Y +V A T K
Sbjct: 741 HGQIRGYQVHYVRMENGEPKGQ---PMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTK 797
Query: 574 GFGQAALTEITTNISA 589
G G + ++ + A
Sbjct: 798 GDGARSKPKLVSTTGA 813
Score = 52.0 bits (123), Expect = 4e-06
Identities = 59/233 (25%), Positives = 86/233 (36%), Gaps = 22/233 (9%)
Query: 347 LDPDTEYEISVLL-TRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWE 405
L P+T Y ++V T GDG R P L+S T L Q +QW
Sbjct: 781 LQPETSYSLTVTAYTTKGDGA--RSKPKLVSTTGAVP---GKPRLVINHTQMNTALIQWH 835
Query: 406 PLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVL 465
P T+ Y G + + +E+ +T ++ + RL
Sbjct: 836 P------PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKE-DHFTATDIHKGASYVFRLSA 888
Query: 466 TNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEP--QEPNGLITQYEIS 523
N G E E+VP+G + + L W+ P E NG+IT+Y +
Sbjct: 889 RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLL 948
Query: 524 YQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576
Y+ I N+P + +T + L P TTY VRA T KG G
Sbjct: 949 YRDI-------NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG 994
Score = 46.2 bits (108), Expect = 2e-04
Identities = 68/343 (19%), Positives = 126/343 (36%), Gaps = 28/343 (8%)
Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPT-PIAPPQLLRA---GPTYLIIQLNTNSIIG-DGP 316
+R +++P+G G S AE+ + + P APPQ + T +++ + +G
Sbjct: 583 FRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 641
Query: 317 IVRKEIEYRMARGPWAEVHAV-----SLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPG 371
I I+Y G + H + Y L L+ TEY I+V T D G G
Sbjct: 642 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPES 699
Query: 372 PPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTL---G 428
++ RT P P+ + + + + + W N + H HY G
Sbjct: 700 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPN--KQHGQIRGYQVHYVRMENG 757
Query: 429 SSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSG 488
Q + + V I L P + + + +G + + G
Sbjct: 758 EPKGQPMLKDVMLADAQDMI-ISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 816
Query: 489 IAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRN 548
+ T + + ++W P + G + Y + + + P T+
Sbjct: 817 KPRLVINHTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDME--------PLTTLEFSEK 867
Query: 549 ETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS 591
E + +++H G +Y+F + AR GFG+ + EI+ P+
Sbjct: 868 EDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 910
Score = 31.6 bits (70), Expect = 5.8
Identities = 63/285 (22%), Positives = 111/285 (38%), Gaps = 34/285 (11%)
Query: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
++ + L WE P+ N + ++I Y + V G T + NL
Sbjct: 1021 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 1067
Query: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
P +Y F + T +G L T +AP P+ +G++ + ITV L P
Sbjct: 1068 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 1122
Query: 617 GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
I Y +I+ ++ R + ++ + L E + R + Y G E+
Sbjct: 1123 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 1181
Query: 674 LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
A FT+GD++ Y GF N L+ + Y ++F A E+++
Sbjct: 1182 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 1240
Query: 728 ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRK 772
P ++ EE GLI + LAV+ ++ I +++ K
Sbjct: 1241 VVSMDLDPQPIT--DEEEGLI-WVVGPVLAVVFIICIVIAILLYK 1282
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 449 bits (1156), Expect = e-126
Identities = 249/615 (40%), Positives = 351/615 (57%), Gaps = 19/615 (3%)
Query: 837 DQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQL--HPAVRVADLLQHINQMKTAEGYGF 894
D R + + P P + + T + HP + + +L HI ++K + F
Sbjct: 887 DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKF 946
Query: 895 KQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYID 950
QEYES G W+ + + +R + AYD RV L + G P +DY+NANYID
Sbjct: 947 SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYID 1006
Query: 951 GYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPE-DSDTY 1009
GY + N +IATQG PE DFWRM+W++ +++VM+TKL E RVKC +YWP ++T+
Sbjct: 1007 GYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETH 1066
Query: 1010 GDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRR 1069
G +++ L+ T LA Y VRTFAL + G S + EVRQF FTAWP+HGVP H T LAF+RR
Sbjct: 1067 GLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRR 1126
Query: 1070 VKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQ 1129
VK PPDAGP+V+HCSAG GRTGC+IV+D ML+ + E VDIY V + ++R M+Q
Sbjct: 1127 VKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ 1186
Query: 1130 TEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPP 1189
TE+QYIFIHDA+LEA CG T +P A +++ +I+ N + + EF+ L S
Sbjct: 1187 TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLAS--SK 1244
Query: 1190 LDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALTDSYTRSAA 1246
A LP N+ KNR ++++P + CL + +G ++YINA+ D Y + A
Sbjct: 1245 AHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFIDGYRQQKA 1302
Query: 1247 FIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVE 1306
+I T PL TT DFWR+++++ T +VML +L + C QYWP +Y V+
Sbjct: 1303 YIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGRE-KCHQYWPAERSARYQYFVVD 1361
Query: 1307 FMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDK 1366
M+ + R F+V + Q VR FQF W + P S + F+ + +V K
Sbjct: 1362 PMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHK 1418
Query: 1367 WQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVET 1425
+ + G DG VHC G GR+G F + VLE +R +VD+F K LR +P MV+T
Sbjct: 1419 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1478
Query: 1426 MDQYHFCYDVALEYL 1440
DQY F Y ALEYL
Sbjct: 1479 EDQYQFSYRAALEYL 1493
Score = 62.8 bits (151), Expect = 2e-09
Identities = 76/342 (22%), Positives = 136/342 (39%), Gaps = 43/342 (12%)
Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Y CV+ + G + A++ VK P P P + + T + + ++ + P+
Sbjct: 300 YTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGN---PEPVSYYI 355
Query: 322 IEYRMARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
I+++ + E+ V+ Y + L P ++YE V+ + G G P P++++T
Sbjct: 356 IQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPVLTQTS 413
Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW----EPLGYNVTRCHTYTVSLCYHYTLGSSHNQTI 435
P AP+ + + + + +QW EP G YT+ H HN
Sbjct: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473
Query: 436 RECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV--PSGIAAES 493
+ TI NL+P + V+++ G + +D V +G+ +
Sbjct: 474 SQIT---------TIGNLVPQKTYSVKVLAFTSIG-----DGPLSSDIQVITQTGVPGQP 519
Query: 494 LTF---TPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNET 550
L F E I L W P+ + I YE+ Y+ E G + I+ + T
Sbjct: 520 LNFKAEPESETSILLSWTPPR--SDTIANYELVYKDGEH--------GEEQRIT-IEPGT 568
Query: 551 YHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF 592
+ L P + Y F + AR+ +G G A+ EI+ F
Sbjct: 569 SYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSMF 609
Score = 62.4 bits (150), Expect = 3e-09
Identities = 61/216 (28%), Positives = 90/216 (41%), Gaps = 23/216 (10%)
Query: 437 ECVKTEQGVS--RYTIKNLLPYRNVHVRLVLTNPEGRKEGKE-VTFQTDEDVPSGIAAES 493
E K GV+ RY++ L PY + R+V N GR E V QT E PS +
Sbjct: 365 ELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDV 424
Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
I ++W+EP+EPNG I Y + Y + DP +V + + +
Sbjct: 425 QARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMK--HNVADSQITT 478
Query: 554 FSNLHPGTTYLFSVRARTGKGFGQ-AALTEITTNISAPSFDYADMPSPL---GESENTIT 609
NL P TY V A T G G ++ ++ T P PL E E+ +
Sbjct: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-------QPLNFKAEPESETS 531
Query: 610 VLLRPAQGRGAPISVYQVIV---EEERARRLRREPG 642
+LL R I+ Y+++ E +R+ EPG
Sbjct: 532 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPG 567
Score = 41.6 bits (96), Expect = 0.006
Identities = 105/465 (22%), Positives = 169/465 (36%), Gaps = 73/465 (15%)
Query: 331 WAEVHAVSLQTYKLWHLDPDTEYEISVL-LTRPGDGG----------TGRPGPPLISRTK 379
W + + Q + +L P Y + VL T GDG TG PG PL +
Sbjct: 466 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-- 523
Query: 380 CAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYT-VSLCYHYTLGSSHNQTIREC 438
AEP + L W P R T L Y H + R
Sbjct: 524 -AEPE-----------SETSILLSWTP-----PRSDTIANYELVYK---DGEHGEEQR-- 561
Query: 439 VKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
+ E G S Y ++ L P + RL +P+G G + + S A
Sbjct: 562 ITIEPGTS-YRLQGLKPNSLYYFRLAARSPQGL--GASTAEISARTMQSMFAKNFHVKAV 618
Query: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
++ + L WE P+ N + ++I Y + V G T + NL
Sbjct: 619 MKTSVLLSWEIPENYNSAMP-FKILY---DDGKMVEEVDG---------RATQKLIVNLK 665
Query: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGES--ENTITVLLRPAQ 616
P +Y F + T +G L T +AP P+ +G++ + ITV L P
Sbjct: 666 PEKSYSFVL---TNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQL-PEV 720
Query: 617 GRGAPISVYQVIV---EEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASS 673
I Y +I+ ++ R + ++ + L E + R + Y G E+
Sbjct: 721 PANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRY-GREVELKP 779
Query: 674 LPEA------MPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKA 727
A FT+GD++ Y GF N L+ + Y ++F A E+++
Sbjct: 780 YIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATSPYSDP 838
Query: 728 ACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRK 772
P ++ EE GLI + LAV+ ++ I +++ K
Sbjct: 839 VVSMDLDPQPIT--DEEEGLI-WVVGPVLAVVFIICIVIAILLYK 880
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 445 bits (1145), Expect = e-124
Identities = 240/579 (41%), Positives = 340/579 (58%), Gaps = 17/579 (2%)
Query: 871 HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYD 926
HP + +AD+ +H ++K + QEYES G W+ + + +R + AYD
Sbjct: 927 HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 986
Query: 927 RHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVM 986
RV L P+ G +DYINANY+DGY N +IATQGP PE DFWRMVW++ ++IVM
Sbjct: 987 HSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVM 1046
Query: 987 ITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQ 1045
+T+L E R+KC +YWP ++TYG I++ L+ T LA + VRTF+L + G S + EVRQ
Sbjct: 1047 MTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1106
Query: 1046 FHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMA 1105
F FTAWP+HGVP + T LAF+RRVK PPDAGPIV+HCSAG GRTGC+IV+D ML+
Sbjct: 1107 FQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI 1166
Query: 1106 ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMI 1165
+ E VD+Y V + S+R M+QTE+QY FIH+A+LEA CG T +P A +++
Sbjct: 1167 KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA 1226
Query: 1166 RIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFL 1222
+++P + + + EF+ L A LP N+ KNR ++++P + CL +
Sbjct: 1227 QVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1284
Query: 1223 ISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQS 1282
+G ++YINA+ D Y + A+I T PL TT DFWR++++ T +VML +L +
Sbjct: 1285 RGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREM 1342
Query: 1283 NSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFL 1342
C QYWP +Y V+ M+ + R F+V + Q VR FQF
Sbjct: 1343 GRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFT 1399
Query: 1343 RWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIR 1401
W + P S + F+ + +V K + + G DG VHC G GR+G F + VLE +R
Sbjct: 1400 DWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMR 1458
Query: 1402 CHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1440
+VD+F K LR +P MV+T D+Y FCY ALEYL
Sbjct: 1459 YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1497
Score = 63.5 bits (153), Expect = 1e-09
Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)
Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Y CV+ + G + A++ VK P P + T + I ++ + P+
Sbjct: 300 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 355
Query: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
IEY+ GP+ ++ Y + L P++EYEI V + G G P +++RT
Sbjct: 356 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 413
Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437
P AP+ + + A + +QW EP+ N + R + ++ + +G+ + +
Sbjct: 414 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 473
Query: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493
+ T T+ +LL VR L T+ + +T + VP + AE+
Sbjct: 474 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 526
Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
+ E I L W P++ + I +YE+ ++ + P T +V
Sbjct: 527 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 571
Query: 554 FSNLHPGTTYLFSVRARTGKGFG 576
+L P T Y F + AR+ +G G
Sbjct: 572 VEDLKPNTEYAFRLAARSPQGLG 594
Score = 42.4 bits (98), Expect = 0.003
Identities = 91/381 (23%), Positives = 139/381 (36%), Gaps = 66/381 (17%)
Query: 350 DTEYEISVL-LTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLG 408
D Y + VL T GDG P+ +T+ P + P L +TL W P
Sbjct: 485 DETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPR 540
Query: 409 YNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNP 468
Y L RE +T + Y +++L P RL +P
Sbjct: 541 QESI----------IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSP 590
Query: 469 EGRKEGKEVTFQ-TDEDV-PSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQS 526
+G V Q T + + P + + ++ + L WE P N T Y+I Y
Sbjct: 591 QGLGAFTPVVRQRTLQSISPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNG 645
Query: 527 IESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTN 586
+ ++V G RT KL ++L P T Y F + T +G L + T
Sbjct: 646 L-----TLDVDG--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTA 688
Query: 587 ISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQD 645
+A + + +P +++ I V L Q P+ Y +++ LR+ GGQ
Sbjct: 689 WTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQF 742
Query: 646 CFPVPLTFEAALA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQT 687
P+ + L R L H E+ S LP F GD +
Sbjct: 743 LTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQ 800
Query: 688 YRGFWNPPLEPRKAYLIYFQA 708
Y GF N LEP Y+++ A
Sbjct: 801 YGGFDNRGLEPGHRYVLFVLA 821
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 445 bits (1145), Expect = e-124
Identities = 240/579 (41%), Positives = 340/579 (58%), Gaps = 17/579 (2%)
Query: 871 HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYD 926
HP + +AD+ +H ++K + QEYES G W+ + + +R + AYD
Sbjct: 1332 HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1391
Query: 927 RHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVM 986
RV L P+ G +DYINANY+DGY N +IATQGP PE DFWRMVW++ ++IVM
Sbjct: 1392 HSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVM 1451
Query: 987 ITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQ 1045
+T+L E R+KC +YWP ++TYG I++ L+ T LA + VRTF+L + G S + EVRQ
Sbjct: 1452 MTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1511
Query: 1046 FHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMA 1105
F FTAWP+HGVP + T LAF+RRVK PPDAGPIV+HCSAG GRTGC+IV+D ML+
Sbjct: 1512 FQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI 1571
Query: 1106 ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMI 1165
+ E VD+Y V + S+R M+QTE+QY FIH+A+LEA CG T +P A +++
Sbjct: 1572 KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA 1631
Query: 1166 RIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFL 1222
+++P + + + EF+ L A LP N+ KNR ++++P + CL +
Sbjct: 1632 QVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1689
Query: 1223 ISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQS 1282
+G ++YINA+ D Y + A+I T PL TT DFWR++++ T +VML +L +
Sbjct: 1690 RGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREM 1747
Query: 1283 NSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFL 1342
C QYWP +Y V+ M+ + R F+V + Q VR FQF
Sbjct: 1748 GRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFT 1804
Query: 1343 RWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIR 1401
W + P S + F+ + +V K + + G DG VHC G GR+G F + VLE +R
Sbjct: 1805 DWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMR 1863
Query: 1402 CHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1440
+VD+F K LR +P MV+T D+Y FCY ALEYL
Sbjct: 1864 YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1902
Score = 63.5 bits (153), Expect = 1e-09
Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)
Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Y CV+ + G + A++ VK P P + T + I ++ + P+
Sbjct: 296 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 351
Query: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
IEY+ GP+ ++ Y + L P++EYEI V + G G P +++RT
Sbjct: 352 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 409
Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437
P AP+ + + A + +QW EP+ N + R + ++ + +G+ + +
Sbjct: 410 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 469
Query: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493
+ T T+ +LL VR L T+ + +T + VP + AE+
Sbjct: 470 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 522
Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
+ E I L W P++ + I +YE+ ++ + P T +V
Sbjct: 523 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 567
Query: 554 FSNLHPGTTYLFSVRARTGKGFG 576
+L P T Y F + AR+ +G G
Sbjct: 568 VEDLKPNTEYAFRLAARSPQGLG 590
Score = 43.5 bits (101), Expect = 0.001
Identities = 77/350 (22%), Positives = 118/350 (33%), Gaps = 46/350 (13%)
Query: 251 LAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRA----GPTYLIIQL 306
L A+ + Q V+ G G + ++ + P APP+ + A ++
Sbjct: 670 LEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWR 729
Query: 307 NTNSIIGDGPIVRKEIEY-RM----ARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLL 359
+ G I ++ Y RM ARGP +V Q + +L P+T Y I+V
Sbjct: 730 SPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAA 789
Query: 360 -TRPGDGGTGRPGPPLISRTKCAEP----MRAPKGLAFAEIQARQLTLQWEPLGYNVTRC 414
T GDG +P + P + P+G A + T + + LGY +
Sbjct: 790 YTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQF- 848
Query: 415 HTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEG 474
+ T ++ RYT + RL + G E
Sbjct: 849 --------------GREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEE 894
Query: 475 KEVTFQTDEDVPSG------IAAESLTFTPLEDMIFLKW--EEPQEPNGLITQYEISYQS 526
ED P G A + T + L+W P E NG I +Y ++ +
Sbjct: 895 AAEVLSIPEDTPRGHPQILEAAGNASAGT-----VLLRWLPPVPAERNGAIVKYTVAVRE 949
Query: 527 IESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576
+ PA P N L P T Y VRA T +G G
Sbjct: 950 AGALGPARETELPAAAEPGAENAL--TLQGLKPDTAYDLQVRAHTRRGPG 997
Score = 40.4 bits (93), Expect = 0.012
Identities = 85/405 (20%), Positives = 146/405 (36%), Gaps = 51/405 (12%)
Query: 262 YRCVSQAPRGAGVSNFAELIVKEP--PTPIAPPQLLRA---GPTYLII-------QLNTN 309
+R +++P+G G F ++ + P APPQ ++ T +++ + +
Sbjct: 579 FRLAARSPQGLGA--FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNG 636
Query: 310 SIIGDG----PIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDG 365
+++G P+ ++ E + G + L+ + W T+Y I+ + +
Sbjct: 637 ALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKW-----TQYRITTVAHT--EV 689
Query: 366 GTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHY 425
G G P++ RT P P+ + + A + + W R H HY
Sbjct: 690 GPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPG--RQHGQIRGYQVHY 747
Query: 426 TLGSSHNQTIRECVKTEQ--GVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDE 483
+K I NL P + + +G + +
Sbjct: 748 VRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTK 807
Query: 484 DVPSGIAAESLTFTPLEDMIFLKWEEPQ-EPNGLITQYEISYQSIESSDPAVNVPGPRRT 542
G S+ TP E + +WE P + Y + + +S+ P T
Sbjct: 808 GAVLGRPTLSVQQTP-EGSLLARWEPPAGTAEDQVLGYRLQFGREDST--------PLAT 858
Query: 543 ISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLG 602
+ +E + S +H G TY+F + AR+ G G+ E +S P P L
Sbjct: 859 LEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGE----EAAEVLSIPEDTPRGHPQILE 914
Query: 603 ESENTI--TVLLR-----PAQGRGAPISVYQVIVEEERARRLRRE 640
+ N TVLLR PA+ GA I Y V V E A RE
Sbjct: 915 AAGNASAGTVLLRWLPPVPAERNGA-IVKYTVAVREAGALGPARE 958
Score = 36.2 bits (82), Expect = 0.24
Identities = 62/250 (24%), Positives = 96/250 (38%), Gaps = 49/250 (19%)
Query: 478 TFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVP 537
TF D+ P + + ++ + L WE P N T Y+I Y + ++V
Sbjct: 1007 TFLRDQVSPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNGL-----TLDVD 1056
Query: 538 GPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYAD 596
G RT KL ++L P T Y F + T +G L + T +A + +
Sbjct: 1057 G--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTAWTAFNLLNGKP 1104
Query: 597 MPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAA 656
+P +++ I V L Q P+ Y +++ LR+ GGQ P+ +
Sbjct: 1105 SVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQFLTPLGSPEDMD 1158
Query: 657 LA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQTYRGFWNPPLEP 698
L R L H E+ S LP F GD + Y GF N LEP
Sbjct: 1159 LEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQYGGFDNRGLEP 1216
Query: 699 RKAYLIYFQA 708
Y+++ A
Sbjct: 1217 GHRYVLFVLA 1226
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 445 bits (1145), Expect = e-124
Identities = 240/579 (41%), Positives = 340/579 (58%), Gaps = 17/579 (2%)
Query: 871 HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYD 926
HP + +AD+ +H ++K + QEYES G W+ + + +R + AYD
Sbjct: 923 HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 982
Query: 927 RHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVM 986
RV L P+ G +DYINANY+DGY N +IATQGP PE DFWRMVW++ ++IVM
Sbjct: 983 HSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVM 1042
Query: 987 ITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQ 1045
+T+L E R+KC +YWP ++TYG I++ L+ T LA + VRTF+L + G S + EVRQ
Sbjct: 1043 MTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1102
Query: 1046 FHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMA 1105
F FTAWP+HGVP + T LAF+RRVK PPDAGPIV+HCSAG GRTGC+IV+D ML+
Sbjct: 1103 FQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI 1162
Query: 1106 ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMI 1165
+ E VD+Y V + S+R M+QTE+QY FIH+A+LEA CG T +P A +++
Sbjct: 1163 KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA 1222
Query: 1166 RIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFL 1222
+++P + + + EF+ L A LP N+ KNR ++++P + CL +
Sbjct: 1223 QVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1280
Query: 1223 ISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQS 1282
+G ++YINA+ D Y + A+I T PL TT DFWR++++ T +VML +L +
Sbjct: 1281 RGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREM 1338
Query: 1283 NSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFL 1342
C QYWP +Y V+ M+ + R F+V + Q VR FQF
Sbjct: 1339 GRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFT 1395
Query: 1343 RWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIR 1401
W + P S + F+ + +V K + + G DG VHC G GR+G F + VLE +R
Sbjct: 1396 DWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMR 1454
Query: 1402 CHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1440
+VD+F K LR +P MV+T D+Y FCY ALEYL
Sbjct: 1455 YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1493
Score = 63.5 bits (153), Expect = 1e-09
Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)
Query: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321
Y CV+ + G + A++ VK P P + T + I ++ + P+
Sbjct: 296 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 351
Query: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379
IEY+ GP+ ++ Y + L P++EYEI V + G G P +++RT
Sbjct: 352 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 409
Query: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437
P AP+ + + A + +QW EP+ N + R + ++ + +G+ + +
Sbjct: 410 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 469
Query: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493
+ T T+ +LL VR L T+ + +T + VP + AE+
Sbjct: 470 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 522
Query: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553
+ E I L W P++ + I +YE+ ++ + P T +V
Sbjct: 523 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 567
Query: 554 FSNLHPGTTYLFSVRARTGKGFG 576
+L P T Y F + AR+ +G G
Sbjct: 568 VEDLKPNTEYAFRLAARSPQGLG 590
Score = 42.4 bits (98), Expect = 0.003
Identities = 91/381 (23%), Positives = 139/381 (36%), Gaps = 66/381 (17%)
Query: 350 DTEYEISVL-LTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLG 408
D Y + VL T GDG P+ +T+ P + P L +TL W P
Sbjct: 481 DETYTVRVLAFTSVGDGPLS---DPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPR 536
Query: 409 YNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNP 468
Y L RE +T + Y +++L P RL +P
Sbjct: 537 QESI----------IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSP 586
Query: 469 EGRKEGKEVTFQ-TDEDV-PSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQS 526
+G V Q T + + P + + ++ + L WE P N T Y+I Y
Sbjct: 587 QGLGAFTPVVRQRTLQSISPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNG 641
Query: 527 IESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTN 586
+ ++V G RT KL ++L P T Y F + T +G L + T
Sbjct: 642 L-----TLDVDG--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTA 684
Query: 587 ISAPSF-DYADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQD 645
+A + + +P +++ I V L Q P+ Y +++ LR+ GGQ
Sbjct: 685 WTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQF 738
Query: 646 CFPVPLTFEAALA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQT 687
P+ + L R L H E+ S LP F GD +
Sbjct: 739 LTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQ 796
Query: 688 YRGFWNPPLEPRKAYLIYFQA 708
Y GF N LEP Y+++ A
Sbjct: 797 YGGFDNRGLEPGHRYVLFVLA 817
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 404 bits (1039), Expect = e-112
Identities = 214/586 (36%), Positives = 334/586 (56%), Gaps = 17/586 (2%)
Query: 867 TGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESF-----FEGWDATKKKDKVKGSRQEP 921
T + +P + V L + IN+ + F++E+ + +A K++ + +R
Sbjct: 205 TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 264
Query: 922 MPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHC 981
+ YD RV L P+ G P++DYINA++I+GY N FIA QGPK E V DFWRM+W+++
Sbjct: 265 ILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNT 324
Query: 982 SSIVMITKLVEVGRVKCSRYWPEDSD-TYGDIKIMLVKTETLAEYVVRTFALERRGYSAR 1040
++IVM+T L E KC++YWP+ TYG+I++ + L +Y VR F +++ G
Sbjct: 325 ATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 384
Query: 1041 HE----VRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYI 1096
+ + QFHFT+WP+ GVP+ G+L F+++VKA P AG IV+HCSAG GRTG ++
Sbjct: 385 RKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFV 444
Query: 1097 VLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSE 1156
V+D MLDM E VD+Y V + ++R M+QT+ QY+FI+ A+LE L G+T + V+
Sbjct: 445 VIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTS 504
Query: 1157 FKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD 1216
+ +++ P ++++ L EEF+ L S+ + ++ LP N KNR + ++P +
Sbjct: 505 LETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVLQIIPYE 562
Query: 1217 RCLPFLISTDGDSN-NYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVM 1275
+ G+ N +Y+NA+ D Y + ++I + PL T DFWR+++++ SIVM
Sbjct: 563 FNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVM 622
Query: 1276 LNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLL 1335
L +L + C QYWP G YG + VE E R V N +
Sbjct: 623 LTELEERGQE-KCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQ-- 679
Query: 1336 VRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAT 1395
+R F F W P K + ++A V K Q +SG+ VHC G GR+GTFCA +T
Sbjct: 680 IRQFHFHGWPEV-GIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALST 738
Query: 1396 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1441
VLE ++ ++DVF K+LR +P+MV+T++QY FCY V EY++
Sbjct: 739 VLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 404 bits (1039), Expect = e-112
Identities = 214/586 (36%), Positives = 334/586 (56%), Gaps = 17/586 (2%)
Query: 867 TGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESF-----FEGWDATKKKDKVKGSRQEP 921
T + +P + V L + IN+ + F++E+ + +A K++ + +R
Sbjct: 214 TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 273
Query: 922 MPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHC 981
+ YD RV L P+ G P++DYINA++I+GY N FIA QGPK E V DFWRM+W+++
Sbjct: 274 ILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNT 333
Query: 982 SSIVMITKLVEVGRVKCSRYWPEDSD-TYGDIKIMLVKTETLAEYVVRTFALERRGYSAR 1040
++IVM+T L E KC++YWP+ TYG+I++ + L +Y VR F +++ G
Sbjct: 334 ATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 393
Query: 1041 HE----VRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYI 1096
+ + QFHFT+WP+ GVP+ G+L F+++VKA P AG IV+HCSAG GRTG ++
Sbjct: 394 RKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFV 453
Query: 1097 VLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSE 1156
V+D MLDM E VD+Y V + ++R M+QT+ QY+FI+ A+LE L G+T + V+
Sbjct: 454 VIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTS 513
Query: 1157 FKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD 1216
+ +++ P ++++ L EEF+ L S+ + ++ LP N KNR + ++P +
Sbjct: 514 LETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVLQIIPYE 571
Query: 1217 RCLPFLISTDGDSN-NYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVM 1275
+ G+ N +Y+NA+ D Y + ++I + PL T DFWR+++++ SIVM
Sbjct: 572 FNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVM 631
Query: 1276 LNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLL 1335
L +L + C QYWP G YG + VE E R V N +
Sbjct: 632 LTELEERGQE-KCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQ-- 688
Query: 1336 VRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAT 1395
+R F F W P K + ++A V K Q +SG+ VHC G GR+GTFCA +T
Sbjct: 689 IRQFHFHGWPEV-GIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALST 747
Query: 1396 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1441
VLE ++ ++DVF K+LR +P+MV+T++QY FCY V EY++
Sbjct: 748 VLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 793
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 404 bits (1039), Expect = e-112
Identities = 214/586 (36%), Positives = 334/586 (56%), Gaps = 17/586 (2%)
Query: 867 TGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESF-----FEGWDATKKKDKVKGSRQEP 921
T + +P + V L + IN+ + F++E+ + +A K++ + +R
Sbjct: 205 TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVN 264
Query: 922 MPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHC 981
+ YD RV L P+ G P++DYINA++I+GY N FIA QGPK E V DFWRM+W+++
Sbjct: 265 ILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNT 324
Query: 982 SSIVMITKLVEVGRVKCSRYWPEDSD-TYGDIKIMLVKTETLAEYVVRTFALERRGYSAR 1040
++IVM+T L E KC++YWP+ TYG+I++ + L +Y VR F +++ G
Sbjct: 325 ATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTN 384
Query: 1041 HE----VRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYI 1096
+ + QFHFT+WP+ GVP+ G+L F+++VKA P AG IV+HCSAG GRTG ++
Sbjct: 385 RKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFV 444
Query: 1097 VLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSE 1156
V+D MLDM E VD+Y V + ++R M+QT+ QY+FI+ A+LE L G+T + V+
Sbjct: 445 VIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTS 504
Query: 1157 FKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD 1216
+ +++ P ++++ L EEF+ L S+ + ++ LP N KNR + ++P +
Sbjct: 505 LETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVLQIIPYE 562
Query: 1217 RCLPFLISTDGDSN-NYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVM 1275
+ G+ N +Y+NA+ D Y + ++I + PL T DFWR+++++ SIVM
Sbjct: 563 FNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVM 622
Query: 1276 LNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLL 1335
L +L + C QYWP G YG + VE E R V N +
Sbjct: 623 LTELEERGQE-KCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQ-- 679
Query: 1336 VRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAT 1395
+R F F W P K + ++A V K Q +SG+ VHC G GR+GTFCA +T
Sbjct: 680 IRQFHFHGWPEV-GIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALST 738
Query: 1396 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLE 1441
VLE ++ ++DVF K+LR +P+MV+T++QY FCY V EY++
Sbjct: 739 VLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 377 bits (967), Expect = e-104
Identities = 212/561 (37%), Positives = 313/561 (55%), Gaps = 17/561 (3%)
Query: 894 FKQEYESFFEG-----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANY 948
F++E+ S G ++ K++ + +R + D RV L + G P +DYINA+Y
Sbjct: 135 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 194
Query: 949 IDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSD- 1007
IDGY N FIA QGPK E V DFWRMVW++ ++IVM+T L E KC +YWP+
Sbjct: 195 IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 254
Query: 1008 TYGDIKIMLVKTETLAEYVVRTFALERR---GYSARHEVRQFHFTAWPEHGVPYHATGLL 1064
TYG+I++ + L +Y +R F ++ + G A V Q HFT+WP+ GVP+ G+L
Sbjct: 255 TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 314
Query: 1065 AFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRR 1124
F+++VK P AGPIV+HCSAG GRTG +IV+D M+ M E VD++ V + ++R
Sbjct: 315 KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 374
Query: 1125 VNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLN 1184
M+QT+ QY FI+ A+LE L G+T + VS + + M + L EEF+ L
Sbjct: 375 PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 434
Query: 1185 SVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG-DSNNYINAALTDSYTR 1243
+V + E LP N K R + ++P D L G + +YINA+ D Y +
Sbjct: 435 NVR--IMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 492
Query: 1244 SAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLM 1303
FI T PL T DFWR+++++ +IVML ++ Q C QYWP G +G +
Sbjct: 493 KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEV-QEREQDKCYQYWPTEGSVTHGEI 551
Query: 1304 EVEFMSGTADEDLVARVFRV---QNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHL 1360
+E + T E + R F V Q +R +E +VR F F W P K + L
Sbjct: 552 TIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDL 610
Query: 1361 LAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKP 1420
+A V K Q ++G+ VHC G GR+GTF A + +LE ++ L+DVF A K+LR +P
Sbjct: 611 IAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRP 670
Query: 1421 NMVETMDQYHFCYDVALEYLE 1441
+MV+T++QY FCY V ++++
Sbjct: 671 HMVQTLEQYEFCYKVVQDFID 691
Score = 131 bits (329), Expect = 5e-30
Identities = 96/284 (33%), Positives = 131/284 (46%), Gaps = 16/284 (5%)
Query: 1162 KEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPF 1221
+E IRI + Q REEF +L S E +A NR+KNR ++LP D
Sbjct: 121 EEEIRIRSADDCKQFREEFNSLPSGHIQGTFE---LANKEENREKNRYPNILPNDHSRVI 177
Query: 1222 LISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLN 1280
L DG ++YINA+ D Y FI P Q T DFWR+V++ +IVML L
Sbjct: 178 LSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLK 237
Query: 1281 QSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQ 1340
+ C QYWP+ G YG + V D R F +Q +L +G R
Sbjct: 238 ERKEE-KCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ--PQLPDGCKAPRLVS 294
Query: 1341 FLRWSAYRD-----TPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAT 1395
L ++++ D TP FL + ++ A G +VHC G GR+GTF
Sbjct: 295 QLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHA----GPIVVHCSAGVGRTGTFIVIDA 350
Query: 1396 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY 1439
++ M+ VDVF +RN +P MV+T QY F Y LEY
Sbjct: 351 MMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY 394
>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
[Homo sapiens]
Length = 642
Score = 377 bits (967), Expect = e-104
Identities = 212/561 (37%), Positives = 313/561 (55%), Gaps = 17/561 (3%)
Query: 894 FKQEYESFFEG-----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANY 948
F++E+ S G ++ K++ + +R + D RV L + G P +DYINA+Y
Sbjct: 77 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 136
Query: 949 IDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSD- 1007
IDGY N FIA QGPK E V DFWRMVW++ ++IVM+T L E KC +YWP+
Sbjct: 137 IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 196
Query: 1008 TYGDIKIMLVKTETLAEYVVRTFALERR---GYSARHEVRQFHFTAWPEHGVPYHATGLL 1064
TYG+I++ + L +Y +R F ++ + G A V Q HFT+WP+ GVP+ G+L
Sbjct: 197 TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 256
Query: 1065 AFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRR 1124
F+++VK P AGPIV+HCSAG GRTG +IV+D M+ M E VD++ V + ++R
Sbjct: 257 KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 316
Query: 1125 VNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLN 1184
M+QT+ QY FI+ A+LE L G+T + VS + + M + L EEF+ L
Sbjct: 317 PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 376
Query: 1185 SVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG-DSNNYINAALTDSYTR 1243
+V + E LP N K R + ++P D L G + +YINA+ D Y +
Sbjct: 377 NVR--IMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 434
Query: 1244 SAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLM 1303
FI T PL T DFWR+++++ +IVML ++ Q C QYWP G +G +
Sbjct: 435 KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEV-QEREQDKCYQYWPTEGSVTHGEI 493
Query: 1304 EVEFMSGTADEDLVARVFRV---QNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHL 1360
+E + T E + R F V Q +R +E +VR F F W P K + L
Sbjct: 494 TIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDL 552
Query: 1361 LAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKP 1420
+A V K Q ++G+ VHC G GR+GTF A + +LE ++ L+DVF A K+LR +P
Sbjct: 553 IAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRP 612
Query: 1421 NMVETMDQYHFCYDVALEYLE 1441
+MV+T++QY FCY V ++++
Sbjct: 613 HMVQTLEQYEFCYKVVQDFID 633
Score = 131 bits (329), Expect = 5e-30
Identities = 96/284 (33%), Positives = 131/284 (46%), Gaps = 16/284 (5%)
Query: 1162 KEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPF 1221
+E IRI + Q REEF +L S E +A NR+KNR ++LP D
Sbjct: 63 EEEIRIRSADDCKQFREEFNSLPSGHIQGTFE---LANKEENREKNRYPNILPNDHSRVI 119
Query: 1222 LISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLN 1280
L DG ++YINA+ D Y FI P Q T DFWR+V++ +IVML L
Sbjct: 120 LSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLK 179
Query: 1281 QSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQ 1340
+ C QYWP+ G YG + V D R F +Q +L +G R
Sbjct: 180 ERKEE-KCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ--PQLPDGCKAPRLVS 236
Query: 1341 FLRWSAYRD-----TPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAT 1395
L ++++ D TP FL + ++ A G +VHC G GR+GTF
Sbjct: 237 QLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHA----GPIVVHCSAGVGRTGTFIVIDA 292
Query: 1396 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY 1439
++ M+ VDVF +RN +P MV+T QY F Y LEY
Sbjct: 293 MMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY 336
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 346 bits (887), Expect = 1e-94
Identities = 211/597 (35%), Positives = 315/597 (52%), Gaps = 46/597 (7%)
Query: 873 AVRVADLLQHINQMKTAEGYGFKQEYESFFEGW--------------DATKKKDKVKGSR 918
A+ + +H+ + + G F +E+E+ E + D++ D +R
Sbjct: 1698 AIPIKHFPKHVADLHASSG--FTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNR 1755
Query: 919 QEPMPAYDRHRVKLHPMLGDPN--ADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMV 976
+ AYD RVKL + DYINANY+DGY+R +IA QGP DFWRM+
Sbjct: 1756 YINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMI 1815
Query: 977 WQEHCSSIVMITKLVEVGRVKCSRYWPED-SDTYGDIKIMLVKTETLAEYVVRTFALE-- 1033
W+ + IVMIT LVE GR KC +YWP D S+ YG+ + + LA Y VR F L
Sbjct: 1816 WEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNT 1875
Query: 1034 ------RRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSA 1087
++G + V Q+H+T WP+ GVP ++ +L F+R+ + GP+V+HCSA
Sbjct: 1876 KIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSA 1935
Query: 1088 GTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLC 1147
G GRTG YIVLD ML + EG V+I+ +K + S+R ++QTEEQY+FIHD ++EA L
Sbjct: 1936 GVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS 1995
Query: 1148 GETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKN 1207
ET + S A Y + I + ++L ++FQ L+ + + S AL NR+KN
Sbjct: 1996 KETEVLDSHIHA-YVNALLIPGPAGKTKLEKQFQLLSQSN--IQQSDYSAALKQCNREKN 2052
Query: 1208 RSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYD 1267
R+ ++P +R + S G+ +YINA+ Y +S FI+T HPL T DFWR+++D
Sbjct: 2053 RTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWD 2112
Query: 1268 YGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQ------QYGLMEVEFMSGTADEDLVARVF 1321
+ +VM+ + N A YWP + LM E + +E L+ + F
Sbjct: 2113 HNAQLVVMIP--DGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDF 2170
Query: 1322 RVQNISRLQEGHLL-VRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHC 1380
++ Q+ ++L VRHFQ +W PDS + L V K +A + DG IVH
Sbjct: 2171 ILE---ATQDDYVLEVRHFQCPKW----PNPDSPISKTFELISVIKEEAANRDGPMIVHD 2223
Query: 1381 LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVAL 1437
+GG +GTFCA T++ + N VDV+ AK + +P + ++QY F Y V L
Sbjct: 2224 EHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL 2280
Score = 115 bits (288), Expect = 3e-25
Identities = 82/291 (28%), Positives = 138/291 (47%), Gaps = 24/291 (8%)
Query: 1173 SSQLREEFQTLNSVTPPLDVEECSIAL--------LPRNRDKNRSMDVLPPDRC---LPF 1221
SS EEF+TL +V+ C++ L P N+ KNR ++++ D L
Sbjct: 1714 SSGFTEEFETLKEFYQ--EVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQ 1771
Query: 1222 LISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQ 1281
L DG +YINA D Y R A+I PL+ST DFWR+++++ IVM+ L +
Sbjct: 1772 LAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVE 1831
Query: 1282 SNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHL------- 1334
C QYWP G ++YG V S R F ++N +++++G
Sbjct: 1832 KGRR-KCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRN-TKIKKGSQKGRPSGR 1889
Query: 1335 LVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACA 1394
+V + + +W P+ L + + + G +VHC G GR+GT+
Sbjct: 1890 VVTQYHYTQWPDM-GVPEYSLPVLTFVRKA-AYAKRHAVGPVVVHCSAGVGRTGTYIVLD 1947
Query: 1395 TVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGLES 1445
++L+ I+ V++F K +R+ + +V+T +QY F +D +E + E+
Sbjct: 1948 SMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKET 1998
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 340 bits (871), Expect = 8e-93
Identities = 213/603 (35%), Positives = 322/603 (53%), Gaps = 43/603 (7%)
Query: 873 AVRVADLLQHINQMKTAEGYGFKQEYESF--------FEGWDATKKKDKVKGSRQEPMPA 924
A+ V ++HI ++ + +GF +++E + ++K K +R + A
Sbjct: 827 AIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHK-NRYINILA 885
Query: 925 YDRHRVKLHPMLG--DPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCS 982
YD RVKL P+ G ++DYINANY+DGY+++ +IATQGP DFWRM+W+++
Sbjct: 886 YDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTG 945
Query: 983 SIVMITKLVEVGRVKCSRYWP-EDSDTYGDIKIMLVKTETLAEYVVRTFALER------- 1034
IVMIT LVE GR KC +YWP E+S+ YG+I + L T+ A Y VR F++
Sbjct: 946 IIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQ 1005
Query: 1035 ----RGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTG 1090
+G V Q+H+T WP+ GVP +A +L F+RR A+ P+ GP+++HCSAG G
Sbjct: 1006 KGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVG 1065
Query: 1091 RTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGET 1150
RTG YIV+D ML + + V++ +K + ++R ++QTEEQYIFIHDA+LEA L ET
Sbjct: 1066 RTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET 1125
Query: 1151 TIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSM 1210
+ ++ +Y I I ++L ++F+ + EC A N++KNR+
Sbjct: 1126 EVSSNQLH-SYVNSILIPGVGGKTRLEKQFKLVTQCN--AKYVECFSAQKECNKEKNRNS 1182
Query: 1211 DVLPPDRCLPFLISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYG 1269
V+P +R L G +YINA+ Y RS FI+T HPL TT DFWR+++D+
Sbjct: 1183 SVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHN 1242
Query: 1270 CTSIVMLNQLNQSNSAWPCLQYWPEPGRQQ------YGLMEVEFMSGTADEDLVARVFRV 1323
IVML NQS A YWP L+ + + + +E ++ F +
Sbjct: 1243 AQIIVMLPD-NQS-LAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFIL 1300
Query: 1324 QNISRLQEGHLL-VRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLN 1382
+ Q+ ++L VRHFQ +W PD+ + L V K +A + DG TIVH
Sbjct: 1301 E---ATQDDYVLEVRHFQCPKW----PNPDAPISSTFELINVIKEEALTRDGPTIVHDEY 1353
Query: 1383 GGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEG 1442
G +G CA T+ + + N VDVF AK + +P + ++QY F Y L +
Sbjct: 1354 GAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST 1413
Query: 1443 LES 1445
E+
Sbjct: 1414 KEN 1416
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
precursor [Homo sapiens]
Length = 1256
Score = 317 bits (812), Expect = 5e-86
Identities = 208/599 (34%), Positives = 302/599 (50%), Gaps = 49/599 (8%)
Query: 877 ADLLQHINQMKTA-EGYGFKQEYESF------FEGWDATKKKDKVKGSRQEPMPAYDRHR 929
AD+L + K A EG F E++S F +A K ++ K + +P YD +R
Sbjct: 585 ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP-YDYNR 643
Query: 930 VKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITK 989
V+L + GD ++YINA+YIDG+ +IA QGP+ E V DFWRM+W++ + IVM+T+
Sbjct: 644 VELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTR 703
Query: 990 LVEVGRVKCSRYWP---EDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR-HEVRQ 1045
E R KC+ YWP E + +GD+ + + + + +Y+++ + + A EV
Sbjct: 704 CEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTH 763
Query: 1046 FHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMA 1105
FT+WP+HGVP LL RRV A + +GPIV+HCSAG GRTG YI +D ML+
Sbjct: 764 IQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGL 823
Query: 1106 ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMI 1165
E E VD+Y V L +R M+Q E QYI IH A++E GET + +SE M
Sbjct: 824 EAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMK 883
Query: 1166 RIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD-RCLPFL-- 1222
+ DP S S L EFQ L S I N+ KNR+ +V+P D +P
Sbjct: 884 KRDPPSEPSPLEAEFQRLPSYR---SWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHE 940
Query: 1223 ------------ISTDGDSNN-----YINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLV 1265
S+D DS++ YINA+ SY + I PL+ T DFW+++
Sbjct: 941 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1000
Query: 1266 YDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQN 1325
+ IVML +L + C QYW E G+Q YG +EV+ RVF +++
Sbjct: 1001 FQRKVKVIVMLTELKHGDQE-ICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRH 1058
Query: 1326 ISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKW--QAESGDGR-------T 1376
R + V +Q+ WS P K + ++ V + Q S +G
Sbjct: 1059 SKR--KDSRTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPL 1115
Query: 1377 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDV 1435
++HC +G ++G FCA +LE +VD+F K LR +P MV T +QY F YDV
Sbjct: 1116 LIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV 1174
Score = 137 bits (344), Expect = 1e-31
Identities = 88/273 (32%), Positives = 132/273 (48%), Gaps = 30/273 (10%)
Query: 898 YESFFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPML-------------GDPNAD-- 942
Y S+ ++++K K +P YD +RV L L D ++D
Sbjct: 904 YRSWRTQHIGNQEENKSKNRNSNVIP-YDYNRVPLKHELEMSKESEHDSDESSDDDSDSE 962
Query: 943 ----YINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKC 998
YINA++I Y + IA QGP E + DFW+M++Q IVM+T+L + C
Sbjct: 963 EPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEIC 1022
Query: 999 SRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPY 1058
++YW E TYGDI++ L T+ + Y +R F L V Q+ +T W +P
Sbjct: 1023 AQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPA 1082
Query: 1059 HATGLLAFIRRVKASTPPD----------AGPIVIHCSAGTGRTGCYIVLDVMLDMAECE 1108
L++ I+ VK P + P++IHC G+ +TG + L +L+ AE E
Sbjct: 1083 EPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETE 1142
Query: 1109 GVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAI 1141
VVDI+ VK L R M+ T EQY F++D I
Sbjct: 1143 EVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI 1175
Score = 114 bits (285), Expect = 7e-25
Identities = 97/363 (26%), Positives = 151/363 (41%), Gaps = 18/363 (4%)
Query: 1080 PIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHD 1139
P ++H S L ++ + +V +Y R N+ E+Q + D
Sbjct: 515 PFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNL--DEQQELVERD 572
Query: 1140 AILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIAL 1199
E L I TYK I EFQ++ V ++E A
Sbjct: 573 D--EKQLMNVEPIHADILLETYKRKIA----DEGRLFLAEFQSIPRVFSKFPIKE---AR 623
Query: 1200 LPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTT 1258
P N++KNR +D+LP D L +GD+ +NYINA+ D + +I P T
Sbjct: 624 KPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETV 683
Query: 1259 PDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWP--EPGRQQYGLMEVEFMSGTADEDL 1316
DFWR++++ T IVM+ + + N C +YWP E G + +G + V+ D
Sbjct: 684 DDFWRMIWEQKATVIVMVTRCEEGNRN-KCAEYWPSMEEGTRAFGDVVVKINQHKRCPDY 742
Query: 1317 VARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRT 1376
+ + + N G V H QF W + P+ L L V+ + + G
Sbjct: 743 IIQKLNIVNKKEKATGRE-VTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAF-SNFFSGPI 799
Query: 1377 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1436
+VHC G GR+GT+ +LE + N VDV+ LR + MV+ QY +
Sbjct: 800 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
Query: 1437 LEY 1439
+EY
Sbjct: 860 VEY 862
Score = 35.0 bits (79), Expect = 0.52
Identities = 50/212 (23%), Positives = 82/212 (38%), Gaps = 31/212 (14%)
Query: 454 LPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
+ YR ++ N E + E E + D S I + FT +I + P EP
Sbjct: 288 ITYRFQCGNMIFDNKEIKLENLEPEHEYKCD--SEILYNNHKFTNASKIIKTDFGSPGEP 345
Query: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKL----------------RNETYHVFSNL 557
+ + E ++Q + + +P P+R+ +N + NL
Sbjct: 346 QIIFCRSEAAHQGVITWNP------PQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNL 399
Query: 558 HPGTTYLFSVRA---RTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRP 614
P T Y+ S+ A + G AA+ TT SAP +M + S+N++ V RP
Sbjct: 400 KPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-SAPPSQVWNMTVSM-TSDNSMHVKCRP 457
Query: 615 AQGRGAPISVYQVIVEEERARRLRREPGGQDC 646
+ R P Y +E E L R ++C
Sbjct: 458 PRDRNGPHERYH--LEVEAGNTLVRNESHKNC 487
Score = 32.3 bits (72), Expect = 3.4
Identities = 27/133 (20%), Positives = 58/133 (43%), Gaps = 16/133 (12%)
Query: 397 ARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPY 456
A Q + W P + H +T LCY +T ++C+ ++ + +Y ++NL PY
Sbjct: 355 AHQGVITWNPPQRSF---HNFT--LCYI-------KETEKDCLNLDKNLIKYDLQNLKPY 402
Query: 457 RNVHVRL---VLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
+ L ++ + F T PS + +++ T ++ + +K P++
Sbjct: 403 TKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDR 461
Query: 514 NGLITQYEISYQS 526
NG +Y + ++
Sbjct: 462 NGPHERYHLEVEA 474
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
precursor [Homo sapiens]
Length = 1304
Score = 317 bits (812), Expect = 5e-86
Identities = 208/599 (34%), Positives = 302/599 (50%), Gaps = 49/599 (8%)
Query: 877 ADLLQHINQMKTA-EGYGFKQEYESF------FEGWDATKKKDKVKGSRQEPMPAYDRHR 929
AD+L + K A EG F E++S F +A K ++ K + +P YD +R
Sbjct: 633 ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP-YDYNR 691
Query: 930 VKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITK 989
V+L + GD ++YINA+YIDG+ +IA QGP+ E V DFWRM+W++ + IVM+T+
Sbjct: 692 VELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTR 751
Query: 990 LVEVGRVKCSRYWP---EDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR-HEVRQ 1045
E R KC+ YWP E + +GD+ + + + + +Y+++ + + A EV
Sbjct: 752 CEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTH 811
Query: 1046 FHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMA 1105
FT+WP+HGVP LL RRV A + +GPIV+HCSAG GRTG YI +D ML+
Sbjct: 812 IQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGL 871
Query: 1106 ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMI 1165
E E VD+Y V L +R M+Q E QYI IH A++E GET + +SE M
Sbjct: 872 EAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMK 931
Query: 1166 RIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD-RCLPFL-- 1222
+ DP S S L EFQ L S I N+ KNR+ +V+P D +P
Sbjct: 932 KRDPPSEPSPLEAEFQRLPSYR---SWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHE 988
Query: 1223 ------------ISTDGDSNN-----YINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLV 1265
S+D DS++ YINA+ SY + I PL+ T DFW+++
Sbjct: 989 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1048
Query: 1266 YDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQN 1325
+ IVML +L + C QYW E G+Q YG +EV+ RVF +++
Sbjct: 1049 FQRKVKVIVMLTELKHGDQE-ICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRH 1106
Query: 1326 ISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKW--QAESGDGR-------T 1376
R + V +Q+ WS P K + ++ V + Q S +G
Sbjct: 1107 SKR--KDSRTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPL 1163
Query: 1377 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDV 1435
++HC +G ++G FCA +LE +VD+F K LR +P MV T +QY F YDV
Sbjct: 1164 LIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV 1222
Score = 137 bits (344), Expect = 1e-31
Identities = 88/273 (32%), Positives = 132/273 (48%), Gaps = 30/273 (10%)
Query: 898 YESFFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPML-------------GDPNAD-- 942
Y S+ ++++K K +P YD +RV L L D ++D
Sbjct: 952 YRSWRTQHIGNQEENKSKNRNSNVIP-YDYNRVPLKHELEMSKESEHDSDESSDDDSDSE 1010
Query: 943 ----YINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKC 998
YINA++I Y + IA QGP E + DFW+M++Q IVM+T+L + C
Sbjct: 1011 EPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEIC 1070
Query: 999 SRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPY 1058
++YW E TYGDI++ L T+ + Y +R F L V Q+ +T W +P
Sbjct: 1071 AQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPA 1130
Query: 1059 HATGLLAFIRRVKASTPPD----------AGPIVIHCSAGTGRTGCYIVLDVMLDMAECE 1108
L++ I+ VK P + P++IHC G+ +TG + L +L+ AE E
Sbjct: 1131 EPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETE 1190
Query: 1109 GVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAI 1141
VVDI+ VK L R M+ T EQY F++D I
Sbjct: 1191 EVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI 1223
Score = 114 bits (285), Expect = 7e-25
Identities = 97/363 (26%), Positives = 151/363 (41%), Gaps = 18/363 (4%)
Query: 1080 PIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHD 1139
P ++H S L ++ + +V +Y R N+ E+Q + D
Sbjct: 563 PFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNL--DEQQELVERD 620
Query: 1140 AILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIAL 1199
E L I TYK I EFQ++ V ++E A
Sbjct: 621 D--EKQLMNVEPIHADILLETYKRKIA----DEGRLFLAEFQSIPRVFSKFPIKE---AR 671
Query: 1200 LPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTT 1258
P N++KNR +D+LP D L +GD+ +NYINA+ D + +I P T
Sbjct: 672 KPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETV 731
Query: 1259 PDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWP--EPGRQQYGLMEVEFMSGTADEDL 1316
DFWR++++ T IVM+ + + N C +YWP E G + +G + V+ D
Sbjct: 732 DDFWRMIWEQKATVIVMVTRCEEGNRN-KCAEYWPSMEEGTRAFGDVVVKINQHKRCPDY 790
Query: 1317 VARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRT 1376
+ + + N G V H QF W + P+ L L V+ + + G
Sbjct: 791 IIQKLNIVNKKEKATGRE-VTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAF-SNFFSGPI 847
Query: 1377 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1436
+VHC G GR+GT+ +LE + N VDV+ LR + MV+ QY +
Sbjct: 848 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907
Query: 1437 LEY 1439
+EY
Sbjct: 908 VEY 910
Score = 35.0 bits (79), Expect = 0.52
Identities = 50/212 (23%), Positives = 82/212 (38%), Gaps = 31/212 (14%)
Query: 454 LPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
+ YR ++ N E + E E + D S I + FT +I + P EP
Sbjct: 336 ITYRFQCGNMIFDNKEIKLENLEPEHEYKCD--SEILYNNHKFTNASKIIKTDFGSPGEP 393
Query: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKL----------------RNETYHVFSNL 557
+ + E ++Q + + +P P+R+ +N + NL
Sbjct: 394 QIIFCRSEAAHQGVITWNP------PQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNL 447
Query: 558 HPGTTYLFSVRA---RTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRP 614
P T Y+ S+ A + G AA+ TT SAP +M + S+N++ V RP
Sbjct: 448 KPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-SAPPSQVWNMTVSM-TSDNSMHVKCRP 505
Query: 615 AQGRGAPISVYQVIVEEERARRLRREPGGQDC 646
+ R P Y +E E L R ++C
Sbjct: 506 PRDRNGPHERYH--LEVEAGNTLVRNESHKNC 535
Score = 32.3 bits (72), Expect = 3.4
Identities = 27/133 (20%), Positives = 58/133 (43%), Gaps = 16/133 (12%)
Query: 397 ARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPY 456
A Q + W P + H +T LCY +T ++C+ ++ + +Y ++NL PY
Sbjct: 403 AHQGVITWNPPQRSF---HNFT--LCYI-------KETEKDCLNLDKNLIKYDLQNLKPY 450
Query: 457 RNVHVRL---VLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
+ L ++ + F T PS + +++ T ++ + +K P++
Sbjct: 451 TKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDR 509
Query: 514 NGLITQYEISYQS 526
NG +Y + ++
Sbjct: 510 NGPHERYHLEVEA 522
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
precursor [Homo sapiens]
Length = 1143
Score = 317 bits (812), Expect = 5e-86
Identities = 208/599 (34%), Positives = 302/599 (50%), Gaps = 49/599 (8%)
Query: 877 ADLLQHINQMKTA-EGYGFKQEYESF------FEGWDATKKKDKVKGSRQEPMPAYDRHR 929
AD+L + K A EG F E++S F +A K ++ K + +P YD +R
Sbjct: 472 ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILP-YDYNR 530
Query: 930 VKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITK 989
V+L + GD ++YINA+YIDG+ +IA QGP+ E V DFWRM+W++ + IVM+T+
Sbjct: 531 VELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTR 590
Query: 990 LVEVGRVKCSRYWP---EDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSAR-HEVRQ 1045
E R KC+ YWP E + +GD+ + + + + +Y+++ + + A EV
Sbjct: 591 CEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTH 650
Query: 1046 FHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMA 1105
FT+WP+HGVP LL RRV A + +GPIV+HCSAG GRTG YI +D ML+
Sbjct: 651 IQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGL 710
Query: 1106 ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMI 1165
E E VD+Y V L +R M+Q E QYI IH A++E GET + +SE M
Sbjct: 711 EAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMK 770
Query: 1166 RIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD-RCLPFL-- 1222
+ DP S S L EFQ L S I N+ KNR+ +V+P D +P
Sbjct: 771 KRDPPSEPSPLEAEFQRLPSYR---SWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHE 827
Query: 1223 ------------ISTDGDSNN-----YINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLV 1265
S+D DS++ YINA+ SY + I PL+ T DFW+++
Sbjct: 828 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 887
Query: 1266 YDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQN 1325
+ IVML +L + C QYW E G+Q YG +EV+ RVF +++
Sbjct: 888 FQRKVKVIVMLTELKHGDQE-ICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRH 945
Query: 1326 ISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKW--QAESGDGR-------T 1376
R + V +Q+ WS P K + ++ V + Q S +G
Sbjct: 946 SKR--KDSRTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPL 1002
Query: 1377 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDV 1435
++HC +G ++G FCA +LE +VD+F K LR +P MV T +QY F YDV
Sbjct: 1003 LIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV 1061
Score = 137 bits (344), Expect = 1e-31
Identities = 88/273 (32%), Positives = 132/273 (48%), Gaps = 30/273 (10%)
Query: 898 YESFFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPML-------------GDPNAD-- 942
Y S+ ++++K K +P YD +RV L L D ++D
Sbjct: 791 YRSWRTQHIGNQEENKSKNRNSNVIP-YDYNRVPLKHELEMSKESEHDSDESSDDDSDSE 849
Query: 943 ----YINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKC 998
YINA++I Y + IA QGP E + DFW+M++Q IVM+T+L + C
Sbjct: 850 EPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEIC 909
Query: 999 SRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPY 1058
++YW E TYGDI++ L T+ + Y +R F L V Q+ +T W +P
Sbjct: 910 AQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPA 969
Query: 1059 HATGLLAFIRRVKASTPPD----------AGPIVIHCSAGTGRTGCYIVLDVMLDMAECE 1108
L++ I+ VK P + P++IHC G+ +TG + L +L+ AE E
Sbjct: 970 EPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETE 1029
Query: 1109 GVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAI 1141
VVDI+ VK L R M+ T EQY F++D I
Sbjct: 1030 EVVDIFQVVKALRKARPGMVSTFEQYQFLYDVI 1062
Score = 114 bits (285), Expect = 7e-25
Identities = 97/363 (26%), Positives = 151/363 (41%), Gaps = 18/363 (4%)
Query: 1080 PIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHD 1139
P ++H S L ++ + +V +Y R N+ E+Q + D
Sbjct: 402 PFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNL--DEQQELVERD 459
Query: 1140 AILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIAL 1199
E L I TYK I EFQ++ V ++E A
Sbjct: 460 D--EKQLMNVEPIHADILLETYKRKIA----DEGRLFLAEFQSIPRVFSKFPIKE---AR 510
Query: 1200 LPRNRDKNRSMDVLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTT 1258
P N++KNR +D+LP D L +GD+ +NYINA+ D + +I P T
Sbjct: 511 KPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETV 570
Query: 1259 PDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWP--EPGRQQYGLMEVEFMSGTADEDL 1316
DFWR++++ T IVM+ + + N C +YWP E G + +G + V+ D
Sbjct: 571 DDFWRMIWEQKATVIVMVTRCEEGNRN-KCAEYWPSMEEGTRAFGDVVVKINQHKRCPDY 629
Query: 1317 VARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRT 1376
+ + + N G V H QF W + P+ L L V+ + + G
Sbjct: 630 IIQKLNIVNKKEKATGRE-VTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAF-SNFFSGPI 686
Query: 1377 IVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA 1436
+VHC G GR+GT+ +LE + N VDV+ LR + MV+ QY +
Sbjct: 687 VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
Query: 1437 LEY 1439
+EY
Sbjct: 747 VEY 749
Score = 35.0 bits (79), Expect = 0.52
Identities = 50/212 (23%), Positives = 82/212 (38%), Gaps = 31/212 (14%)
Query: 454 LPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
+ YR ++ N E + E E + D S I + FT +I + P EP
Sbjct: 175 ITYRFQCGNMIFDNKEIKLENLEPEHEYKCD--SEILYNNHKFTNASKIIKTDFGSPGEP 232
Query: 514 NGLITQYEISYQSIESSDPAVNVPGPRRTISKL----------------RNETYHVFSNL 557
+ + E ++Q + + +P P+R+ +N + NL
Sbjct: 233 QIIFCRSEAAHQGVITWNP------PQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNL 286
Query: 558 HPGTTYLFSVRA---RTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRP 614
P T Y+ S+ A + G AA+ TT SAP +M + S+N++ V RP
Sbjct: 287 KPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-SAPPSQVWNMTVSM-TSDNSMHVKCRP 344
Query: 615 AQGRGAPISVYQVIVEEERARRLRREPGGQDC 646
+ R P Y +E E L R ++C
Sbjct: 345 PRDRNGPHERYH--LEVEAGNTLVRNESHKNC 374
Score = 32.3 bits (72), Expect = 3.4
Identities = 27/133 (20%), Positives = 58/133 (43%), Gaps = 16/133 (12%)
Query: 397 ARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPY 456
A Q + W P + H +T LCY +T ++C+ ++ + +Y ++NL PY
Sbjct: 242 AHQGVITWNPPQRSF---HNFT--LCYI-------KETEKDCLNLDKNLIKYDLQNLKPY 289
Query: 457 RNVHVRL---VLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEP 513
+ L ++ + F T PS + +++ T ++ + +K P++
Sbjct: 290 TKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTS-DNSMHVKCRPPRDR 348
Query: 514 NGLITQYEISYQS 526
NG +Y + ++
Sbjct: 349 NGPHERYHLEVEA 361
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,403,302
Number of Sequences: 37866
Number of extensions: 2867951
Number of successful extensions: 8579
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 136
Number of HSP's successfully gapped in prelim test: 124
Number of HSP's that attempted gapping in prelim test: 6869
Number of HSP's gapped (non-prelim): 941
length of query: 1446
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1331
effective length of database: 13,892,928
effective search space: 18491487168
effective search space used: 18491487168
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.