Search of human proteins with 163914396

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
         (936 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]       1892   0.0  
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]         1667   0.0  
gi|62530386 fucose-1-phosphate guanyltransferase [Homo sapiens]       231   2e-60
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   164   4e-40
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   159   2e-38
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        158   3e-38
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       157   3e-38
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        157   3e-38
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        157   3e-38
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        157   3e-38
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        157   3e-38
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       157   6e-38
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        157   6e-38
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        157   6e-38
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H...   155   2e-37
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso...   155   2e-37
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso...   155   2e-37
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso...   155   2e-37
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof...   155   2e-37
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]               141   2e-33
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]               141   2e-33
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho...   139   2e-32
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    137   5e-32
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho...   135   1e-31
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  135   2e-31
gi|62420875 integrin-linked kinase [Homo sapiens]                     134   5e-31
gi|62420873 integrin-linked kinase [Homo sapiens]                     134   5e-31
gi|4758606 integrin-linked kinase [Homo sapiens]                      134   5e-31
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   131   3e-30
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    131   3e-30

>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
          Length = 936

 Score = 1892 bits (4902), Expect = 0.0
 Identities = 936/936 (100%), Positives = 936/936 (100%)

Query: 1   MAAARDPPEVSLREATQRKLRRFSELRGKLVARGEFWDIVAITAADEKQELAYNQQLSEK 60
           MAAARDPPEVSLREATQRKLRRFSELRGKLVARGEFWDIVAITAADEKQELAYNQQLSEK
Sbjct: 1   MAAARDPPEVSLREATQRKLRRFSELRGKLVARGEFWDIVAITAADEKQELAYNQQLSEK 60

Query: 61  LKRKELPLGVQYHVFVDPAGAKIGNGGSTLCALQCLEKLYGDKWNSFTILLIHSDEWKKK 120
           LKRKELPLGVQYHVFVDPAGAKIGNGGSTLCALQCLEKLYGDKWNSFTILLIHSDEWKKK
Sbjct: 61  LKRKELPLGVQYHVFVDPAGAKIGNGGSTLCALQCLEKLYGDKWNSFTILLIHSDEWKKK 120

Query: 121 VSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGG 180
           VSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGG
Sbjct: 121 VSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGG 180

Query: 181 KKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALH 240
           KKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALH
Sbjct: 181 KKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALH 240

Query: 241 IATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEV 300
           IATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEV
Sbjct: 241 IATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEV 300

Query: 301 GDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDL 360
           GDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDL
Sbjct: 301 GDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDL 360

Query: 361 EVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSI 420
           EVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSI
Sbjct: 361 EVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSI 420

Query: 421 DLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGE 480
           DLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGE
Sbjct: 421 DLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGE 480

Query: 481 KDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMT 540
           KDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMT
Sbjct: 481 KDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMT 540

Query: 541 KEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCS 600
           KEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCS
Sbjct: 541 KEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCS 600

Query: 601 KSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILD 660
           KSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILD
Sbjct: 601 KSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILD 660

Query: 661 LQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDED 720
           LQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDED
Sbjct: 661 LQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDED 720

Query: 721 NMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAY 780
           NMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAY
Sbjct: 721 NMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAY 780

Query: 781 HHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPASSNSSGS 840
           HHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPASSNSSGS
Sbjct: 781 HHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPASSNSSGS 840

Query: 841 LSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAALSQSAGQYSSQGLSLEEMK 900
           LSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAALSQSAGQYSSQGLSLEEMK
Sbjct: 841 LSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAALSQSAGQYSSQGLSLEEMK 900

Query: 901 RSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS 936
           RSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS
Sbjct: 901 RSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS 936


>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
          Length = 835

 Score = 1667 bits (4317), Expect = 0.0
 Identities = 822/823 (99%), Positives = 823/823 (100%)

Query: 114 SDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLH 173
           +DEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLH
Sbjct: 13  TDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLH 72

Query: 174 LCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGY 233
           LCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGY
Sbjct: 73  LCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGY 132

Query: 234 GGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGAD 293
           GGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGAD
Sbjct: 133 GGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGAD 192

Query: 294 VNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVK 353
           VNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVK
Sbjct: 193 VNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVK 252

Query: 354 YLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSA 413
           YLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSA
Sbjct: 253 YLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSA 312

Query: 414 CTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACD 473
           CTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACD
Sbjct: 313 CTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACD 372

Query: 474 PSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPL 533
           PSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPL
Sbjct: 373 PSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPL 432

Query: 534 GKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRY 593
           GKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRY
Sbjct: 433 GKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRY 492

Query: 594 RANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH 653
           RANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH
Sbjct: 493 RANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH 552

Query: 654 EQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRF 713
           EQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRF
Sbjct: 553 EQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRF 612

Query: 714 LQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAA 773
           LQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAA
Sbjct: 613 LQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAA 672

Query: 774 AAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPA 833
           AAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPA
Sbjct: 673 AAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPA 732

Query: 834 SSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAALSQSAGQYSSQG 893
           SSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAALSQSAGQYSSQG
Sbjct: 733 SSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAALSQSAGQYSSQG 792

Query: 894 LSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS 936
           LSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS
Sbjct: 793 LSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS 835


>gi|62530386 fucose-1-phosphate guanyltransferase [Homo sapiens]
          Length = 594

 Score =  231 bits (589), Expect = 2e-60
 Identities = 114/121 (94%), Positives = 118/121 (97%)

Query: 1   MAAARDPPEVSLREATQRKLRRFSELRGKLVARGEFWDIVAITAADEKQELAYNQQLSEK 60
           MAAARDPPEVSLREATQRKLRRFSELRGKLVARGEFWDIVAITAADEKQELAYNQQLSEK
Sbjct: 1   MAAARDPPEVSLREATQRKLRRFSELRGKLVARGEFWDIVAITAADEKQELAYNQQLSEK 60

Query: 61  LKRKELPLGVQYHVFVDPAGAKIGNGGSTLCALQCLEKLYGDKWNSFTILLIHSDEWKKK 120
           LKRKELPLGVQYHVFVDPAGAKIGNGGSTLCALQCLEKLYGDKWNSFTILLIHS  + ++
Sbjct: 61  LKRKELPLGVQYHVFVDPAGAKIGNGGSTLCALQCLEKLYGDKWNSFTILLIHSGGYSQR 120

Query: 121 V 121
           +
Sbjct: 121 L 121


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  164 bits (415), Expect = 4e-40
 Identities = 112/347 (32%), Positives = 171/347 (49%), Gaps = 17/347 (4%)

Query: 156 FSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNA 215
           F K ++N++     + LH     G  +  I  L+L G R +       T LH AV   + 
Sbjct: 29  FKKEDVNFQDNEKRTPLHAAAYLGDAEI-IELLILSGARVNAKDSKWLTPLHRAVASCSE 87

Query: 216 ELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIA 275
           E +  LL   AD+        T LHIA     ++ A+ L+   +NVN+ D    T LH A
Sbjct: 88  EAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHA 147

Query: 276 AYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNE 335
           A+ GH ++ +LLL  GA++N   +   R +H A+  G + + KLL+  G  A+V  +D +
Sbjct: 148 AFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHG--AEVTCKDKK 205

Query: 336 DHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG 395
            + PLH  +  G   +VKYLL  DL V  +  N YG+TPLH+ACYNG+  V  E+I    
Sbjct: 206 SYTPLHAAASSGMISVVKYLL--DLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263

Query: 396 TESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIR 455
             +   E  F+   F +A T+G    L   LL  N  ++N + +DG T LH    HG   
Sbjct: 264 IVNQKNEKGFTPLHFAAASTHGA---LCLELLVGNGADVNMKSKDGKTPLHMTALHGRFS 320

Query: 456 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
             Q ++ +GA   ++ C+      +K+  T L  A   GH+ ++  L
Sbjct: 321 RSQTIIQSGA---VIDCE------DKNGNTPLHIAARYGHELLINTL 358



 Score =  116 bits (290), Expect = 1e-25
 Identities = 84/269 (31%), Positives = 126/269 (46%), Gaps = 7/269 (2%)

Query: 200 RNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGA 259
           R G TALH A +  + E++  LL  GA+I         A+H A   GH+E   +L+ HGA
Sbjct: 138 RAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 197

Query: 260 NVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKL 319
            V  +D   +TPLH AA  G   V + LL  G D+N     G+ PLH+A   G   +   
Sbjct: 198 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNE 257

Query: 320 LMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLAC 379
           L++ G  A VN ++ +   PLHF +   H  +   LL  +     ++ +  G TPLH+  
Sbjct: 258 LIDCG--AIVNQKNEKGFTPLHFAAASTHGALCLELLVGN-GADVNMKSKDGKTPLHMTA 314

Query: 380 YNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGR 439
            +G+F  ++ IIQ         +N    T  H A  YG  + L+  L+     +   +G 
Sbjct: 315 LHGRFSRSQTIIQSGAVIDCEDKN--GNTPLHIAARYGHEL-LINTLITSGA-DTAKRGI 370

Query: 440 DGHTGLHSACYHGHIRLVQFLLDNGADMN 468
            G   LH A   G     + LL +G D++
Sbjct: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDID 399



 Score =  113 bits (282), Expect = 9e-25
 Identities = 103/358 (28%), Positives = 163/358 (45%), Gaps = 30/358 (8%)

Query: 146 LRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTA 205
           LR + G+ E  + V++  +  NG + L L  +  G    + +L+ KG       + G TA
Sbjct: 633 LRLLIGNAEPQNAVDI--QDGNGQTPLMLS-VLNGHTDCVYSLLNKGANVDAKDKWGRTA 689

Query: 206 LHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQD 265
           LH      + E + +LL  GA        G T +H++   GH+     LLQ  A+++   
Sbjct: 690 LHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANP 749

Query: 266 AVF----FTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLM 321
           A      +T LH A Y GHE    LLL+        G     PLH A        A++L+
Sbjct: 750 ATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFS-PLHCAVINDNEGAAEMLI 808

Query: 322 EEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYN 381
           +    + VNA D++   PLH  +   H + ++ LL  + +V  + V+  G TPL +A  N
Sbjct: 809 DTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQV--NSVDSTGKTPLMMAAEN 866

Query: 382 GKFEVAKEIIQISGTESLTKENIFSETAFHSACTYG---KSIDLVKFLLDQNVININHQG 438
           G+     E++  S +  LT ++    TA H AC+ G    ++ +++ + D+N+IN  +  
Sbjct: 867 GQTNTV-EMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAA 925

Query: 439 RDGHTGLHSACYHGHIRLVQFLLDNGADMNLV---------ACDPSRSSGEKDEQTCL 487
               T LH A  +G   +VQ LL  GA +  V         AC P+     KD   CL
Sbjct: 926 L--QTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPN-----KDVADCL 976



 Score =  112 bits (280), Expect = 2e-24
 Identities = 93/319 (29%), Positives = 157/319 (49%), Gaps = 18/319 (5%)

Query: 160 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 219
           ++N ++++G + LH+  +  G+ S  +T++  G       +NG T LH+A    +  LI 
Sbjct: 298 DVNMKSKDGKTPLHMTAL-HGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLIN 356

Query: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279
           +L+ SGAD  + G  G+  LH+A ++G  +    LL  G +++  D    T LH AA  G
Sbjct: 357 TLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGG 416

Query: 280 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 339
           + +   LLL  GAD N   + G  PLH A+A    N   L    GS A VN  D     P
Sbjct: 417 NLECLNLLLNTGADFNKKDKFGRSPLHYAAAN--CNYQCLFALVGSGASVNDLDERGCTP 474

Query: 340 LHFCSRFG-HHDIVKYLLQSDLEVQPHVVNIYGDTPLHL-ACYNGKF---EVAKE----- 389
           LH+ +        ++YLL++D    P + +  G   +H  A Y  +     +A E     
Sbjct: 475 LHYAATSDTDGKCLEYLLRND--ANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDV 532

Query: 390 IIQISGTESLT-KENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSA 448
           +++ SGT+ L+  +N  + +  H A  +G    L   +L Q++++++ +   G T L  A
Sbjct: 533 LMETSGTDMLSDSDNRATISPLHLAAYHGHHQALE--VLVQSLLDLDVRNSSGRTPLDLA 590

Query: 449 CYHGHIRLVQFLLDNGADM 467
            + GH+  V  L++ GA +
Sbjct: 591 AFKGHVECVDVLINQGASI 609



 Score =  108 bits (271), Expect = 2e-23
 Identities = 93/343 (27%), Positives = 143/343 (41%), Gaps = 55/343 (16%)

Query: 200 RNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGA 259
           R   + LHLA Y  + + +  L+ S  D+      G T L +A   GH+E  DVL+  GA
Sbjct: 548 RATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA 607

Query: 260 NVNIQDAVF-FTPLHIAAYYGHEQVTRL-------------------------------- 286
           ++ ++D +   TP+H AA  GH +  RL                                
Sbjct: 608 SILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTD 667

Query: 287 ----LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 342
               LL  GA+V+   + G   LH  +  G       L++ G+K  +  +D+    P+H 
Sbjct: 668 CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLL--RDSRGRTPIHL 725

Query: 343 CSRFGHHDIVKYLLQS--DLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLT 400
            +  GH  ++  LLQS   ++  P   + +G T LH ACYNG  E   E++        T
Sbjct: 726 SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNG-HETCVELLLEQEVFQKT 784

Query: 401 KENIFSETAFHSACTYGKSIDLVKFLLDQ-NVININHQGRDGHTGLHSACYHGHIRLVQF 459
           + N FS    H A     +    + L+D      +N     G T LH+A +  H+  +Q 
Sbjct: 785 EGNAFS--PLHCA-VINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL 841

Query: 460 LLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
           LL + A +N V         +   +T LM A E G    V +L
Sbjct: 842 LLSHNAQVNSV---------DSTGKTPLMMAAENGQTNTVEML 875



 Score =  105 bits (263), Expect = 2e-22
 Identities = 124/483 (25%), Positives = 179/483 (37%), Gaps = 120/483 (24%)

Query: 135 DLQIKEKE------LTELRNIFGSDEAF--SKVNLNYRTENGLSLLHLCCICGGKKSHIR 186
           D+ +K K+      +T L   F   +    S   ++   +NG + LH+    G +   I 
Sbjct: 298 DVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELL-IN 356

Query: 187 TLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAG 246
           TL+  G   ++   +G   LHLA     ++    LL SG DI      G T LH A   G
Sbjct: 357 TLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGG 416

Query: 247 HLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLH 306
           +LE  ++LL  GA+ N +D    +PLH AA   + Q    L+  GA VN   E G  PLH
Sbjct: 417 NLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLH 476

Query: 307 LASA-----------------------KGFLNI--------------------AKLLMEE 323
            A+                        +G+  +                      +LME 
Sbjct: 477 YAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMET 536

Query: 324 GSKADVNAQDNEDHV-PLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNG 382
                ++  DN   + PLH  +  GHH  ++ L+QS L++   V N  G TPL LA + G
Sbjct: 537 SGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLD--VRNSSGRTPLDLAAFKG 594

Query: 383 KFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKS----------------------- 419
             E    +I   G   L K+ I   T  H+A T G S                       
Sbjct: 595 HVECVDVLIN-QGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNG 653

Query: 420 ------------IDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADM 467
                        D V  LL++   N++ + + G T LH     GH   V  LL +GA  
Sbjct: 654 QTPLMLSVLNGHTDCVYSLLNKGA-NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKC 712

Query: 468 NL------------VAC----------------DPSRSSGEKDEQTCLMWAYEKGHDAIV 499
            L             AC                D + ++ +    T L WA   GH+  V
Sbjct: 713 LLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCV 772

Query: 500 TLL 502
            LL
Sbjct: 773 ELL 775



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 91/353 (25%), Positives = 146/353 (41%), Gaps = 26/353 (7%)

Query: 161 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 220
           +N + E G + LH           +  L+  G   +  +++G T LH+           +
Sbjct: 265 VNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQT 324

Query: 221 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 280
           ++ SGA I      G T LHIA   GH    + L+  GA+   +      PLH+AA  G 
Sbjct: 325 IIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGF 384

Query: 281 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPL 340
               R LL  G D++   + G   LH A+A G L    LL+  G  AD N +D     PL
Sbjct: 385 SDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTG--ADFNKKDKFGRSPL 442

Query: 341 HFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLT 400
           H+ +   ++  +  L+ S   V    ++  G TPLH A  +       E +  +      
Sbjct: 443 HYAAANCNYQCLFALVGSGASVND--LDERGCTPLHYAATSDTDGKCLEYLLRNDANPGI 500

Query: 401 KENIFSETAFHSACTYGKSIDLVKFLLDQNVINI-----------NHQGRDGHTGLHSAC 449
           ++      A H +  YG  + L + +  +  +++           +   R   + LH A 
Sbjct: 501 RDK-QGYNAVHYSAAYGHRLCL-QLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 558

Query: 450 YHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
           YHGH + ++ L+ +  D+     D   SSG    +T L  A  KGH   V +L
Sbjct: 559 YHGHHQALEVLVQSLLDL-----DVRNSSG----RTPLDLAAFKGHVECVDVL 602


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  159 bits (401), Expect = 2e-38
 Identities = 105/332 (31%), Positives = 164/332 (49%), Gaps = 17/332 (5%)

Query: 172 LHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQV 231
           LH+    G  +  I  L+L G R +       T LH AV   + E +  L+   AD+   
Sbjct: 20  LHVAAFLGDAEI-IELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNAR 78

Query: 232 GYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFG 291
                T LH+A     ++ A+V++   ++VN+ D    T LH AA  GH ++  LLL  G
Sbjct: 79  DKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKG 138

Query: 292 ADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDI 351
           A++N   +   R LH A+  G L++  LL+  G  A+V  +D + + PLH  +  G  ++
Sbjct: 139 ANINAFDKKDRRALHWAAYMGHLDVVALLINHG--AEVTCKDKKGYTPLHAAASNGQINV 196

Query: 352 VKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFH 411
           VK+LL   +E+    +N+YG+T LH+ACYNG+  V  E+I      +    N F+   F 
Sbjct: 197 VKHLLNLGVEIDE--INVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFA 254

Query: 412 SACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVA 471
           +A T+G    L   LL  N  ++N Q +DG + LH    HG     Q L+ NG +++ V 
Sbjct: 255 AASTHGA---LCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCV- 310

Query: 472 CDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLK 503
                   +KD  T L  A   GH+ ++  L+
Sbjct: 311 --------DKDGNTPLHVAARYGHELLINTLR 334



 Score =  107 bits (266), Expect = 7e-23
 Identities = 86/323 (26%), Positives = 141/323 (43%), Gaps = 36/323 (11%)

Query: 168 GLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL-HSGA 226
           G + LH+ C   G+ + +  L+  G   ++   NGFT LH A    +  L   LL ++GA
Sbjct: 214 GNTALHIACY-NGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGA 272

Query: 227 DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRL 286
           D+      G + LH+  + G    +  L+Q+G  ++  D    TPLH+AA YGHE +   
Sbjct: 273 DVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINT 332

Query: 287 LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRF 346
           L   GAD    G     PLHLA+     +  + L+  G   +++  D      LH  +  
Sbjct: 333 LRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSG--FEIDTPDKFGRTCLHAAAAG 390

Query: 347 GHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFS 406
           G+ + +K L  S  +   H  +  G TPLH A  N  F   + ++      + T +  + 
Sbjct: 391 GNVECIKLLQSSGADF--HKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDD--WG 446

Query: 407 ETAFHSACT---------YGKSID------------------LVKFLLDQNVININHQGR 439
            TA H A            G + D                   ++FLL QN  N + + +
Sbjct: 447 RTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLL-QNDANPSIRDK 505

Query: 440 DGHTGLHSACYHGHIRLVQFLLD 462
           +G+  +H A  +GH + ++ LL+
Sbjct: 506 EGYNSIHYAAAYGHRQCLELLLE 528



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 87/360 (24%), Positives = 158/360 (43%), Gaps = 39/360 (10%)

Query: 160 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 219
           ++N ++++G S LH+  +  G+ +  +TL+  G     + ++G T LH+A    +  LI 
Sbjct: 273 DVNIQSKDGKSPLHMTAV-HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLIN 331

Query: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279
           +L  SGAD  + G   +  LH+A +  H +    LL  G  ++  D    T LH AA  G
Sbjct: 332 TLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGG 391

Query: 280 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 339
           + +  +LL   GAD +   + G  PLH A+A    +  + L+  G  A+VN  D+     
Sbjct: 392 NVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTG--ANVNETDDWGRTA 449

Query: 340 LHFCSRF----------GHHD------------------IVKYLLQSDLEVQPHVVNIYG 371
           LH+ +              HD                   +++LLQ+D    P + +  G
Sbjct: 450 LHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQND--ANPSIRDKEG 507

Query: 372 DTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNV 431
              +H A   G  +  + +++ + +     ++  +++  H A   G    L   L  Q++
Sbjct: 508 YNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLL--QSL 565

Query: 432 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADM----NLVACDPSRSSGEKDEQTCL 487
           ++++ +   G T L  A + GH   V+ L++ GA +    N+    P  +S       CL
Sbjct: 566 VDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCL 625



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 97/367 (26%), Positives = 161/367 (43%), Gaps = 25/367 (6%)

Query: 157 SKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLR---PSRLTRNGFTALHLAVYKD 213
           S V+L+ R E G + L L    G  +  +  L+  G        +T+   T LH +V   
Sbjct: 564 SLVDLDIRDEKGRTALDLAAFKGHTEC-VEALINPGASIFVKDNVTKR--TPLHASVING 620

Query: 214 NAELITSLLHSGADIQQVGYG---GLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFT 270
           +   +  LL    + + V      G T L +A   GH++A  +LL+  ANV+  D +  T
Sbjct: 621 HTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCT 680

Query: 271 PLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLN-IAKLLMEEGSKADV 329
            LH     GHE+  ++LL+    +      G  PLH A+A+G    +++LL    S+ D 
Sbjct: 681 ALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDC 740

Query: 330 NAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKE 389
             +DN+ + PLH+    G+ + ++ LL+     +  + N +  TPLH A  N     A  
Sbjct: 741 CFKDNQGYTPLHWACYNGNENCIEVLLEQKC-FRKFIGNPF--TPLHCAIINDHGNCASL 797

Query: 390 IIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSAC 449
           ++    +  ++  +    T   +A  +   ++ ++ LL ++   +N     G T L  A 
Sbjct: 798 LLGAIDSSIVSCRDDKGRTPLRAA-AFADHVECLQLLL-RHSAPVNAVDNSGKTALMMAA 855

Query: 450 YHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQ 509
            +G    V  L+ N A  +L   D       KD  T L  A  KGH+    L+    + Q
Sbjct: 856 ENGQAGAVDILV-NSAQADLTVKD-------KDLNTPLHLACSKGHEKCALLI--LDKIQ 905

Query: 510 DELPCNE 516
           DE   NE
Sbjct: 906 DESLINE 912



 Score = 90.5 bits (223), Expect = 7e-18
 Identities = 93/349 (26%), Positives = 146/349 (41%), Gaps = 35/349 (10%)

Query: 180 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 239
           G +  I TL   G   ++   +    LHLA    +++    LL SG +I      G T L
Sbjct: 325 GHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCL 384

Query: 240 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGE 299
           H A   G++E   +L   GA+ + +D    TPLH AA   H      L+  GA+VN + +
Sbjct: 385 HAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDD 444

Query: 300 VGDRPLHLASAKGF----------------LNIAKLLMEE----------GSKADVNAQD 333
            G   LH A+A                   L  A+ L E+           + A+ + +D
Sbjct: 445 WGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRD 504

Query: 334 NEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQI 393
            E +  +H+ + +GH   ++ LL+          +    +PLHLA YNG  +  + ++Q 
Sbjct: 505 KEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQS 564

Query: 394 SGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGH 453
                +  E     TA   A   G + + V+ L++              T LH++  +GH
Sbjct: 565 LVDLDIRDEK--GRTALDLAAFKGHT-ECVEALINPGASIFVKDNVTKRTPLHASVINGH 621

Query: 454 IRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
              ++ LL+  AD N  A D   + G    QT LM A   GH   V+LL
Sbjct: 622 TLCLRLLLEI-AD-NPEAVDVKDAKG----QTPLMLAVAYGHIDAVSLL 664



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 73/249 (29%), Positives = 110/249 (44%), Gaps = 41/249 (16%)

Query: 253 VLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKG 312
           +L+    +VN  D+   TPLH+AA+ G  ++  LL+  GA VN    +   PLH A A  
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 313 FLNIAKLLMEEGSKADVNAQDNEDHVPLHF--------CSRF------------------ 346
                ++L++    ADVNA+D     PLH         C+                    
Sbjct: 61  SEEAVQVLIKH--SADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTA 118

Query: 347 -------GHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESL 399
                  GH ++V  LL     +  +  +      LH A Y G  +V   +I   G E  
Sbjct: 119 LHHAALNGHVEMVNLLLAKGANI--NAFDKKDRRALHWAAYMGHLDVVALLIN-HGAEVT 175

Query: 400 TKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQF 459
            K+     T  H+A + G+ I++VK LL+  V  I+     G+T LH ACY+G   +V  
Sbjct: 176 CKDK-KGYTPLHAAASNGQ-INVVKHLLNLGV-EIDEINVYGNTALHIACYNGQDAVVNE 232

Query: 460 LLDNGADMN 468
           L+D GA++N
Sbjct: 233 LIDYGANVN 241


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  158 bits (399), Expect = 3e-38
 Identities = 102/301 (33%), Positives = 162/301 (53%), Gaps = 10/301 (3%)

Query: 180 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 239
           GK   ++ L+ +G  P+  T +G+T LHL+  + + ++   LL  GA +      G T L
Sbjct: 510 GKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPL 569

Query: 240 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGE 299
           H+A   G LE A++LLQ  A+ +       TPLH+AA+Y +++V  LLL  GA  + + +
Sbjct: 570 HVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAK 629

Query: 300 VGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD 359
            G  PLH+A+ K  ++IA  L+E G  AD NA   +    +H  ++ GH D+V  LL  +
Sbjct: 630 NGYTPLHIAAKKNQMDIATTLLEYG--ADANAVTRQGIASVHLAAQEGHVDMVSLLLGRN 687

Query: 360 LEVQPHVVNIYGDTPLHLACYNGKFEVAKEII-QISGTESLTKENIFSETAFHSACTYGK 418
             V  ++ N  G TPLHLA    +  VA+ ++ Q +  ++ TK      T  H  C YG 
Sbjct: 688 ANV--NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK---MGYTPLHVGCHYG- 741

Query: 419 SIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSS 478
           +I +V FLL Q+   +N + ++G+T LH A   GH  ++  LL N A  N +  + + + 
Sbjct: 742 NIKIVNFLL-QHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTAL 800

Query: 479 G 479
           G
Sbjct: 801 G 801



 Score =  152 bits (385), Expect = 1e-36
 Identities = 107/338 (31%), Positives = 164/338 (48%), Gaps = 18/338 (5%)

Query: 165 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 224
           T + L+ LH+   CG  K   + L+ K   P+    NGFT LH+A  K+  +++  LL  
Sbjct: 364 TNDYLTALHVAAHCGHYKV-AKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKH 422

Query: 225 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 284
           GA IQ V   GLT +H+A   GH+     L+ HGA+ N  +    T LH+AA  G  +V 
Sbjct: 423 GASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVV 482

Query: 285 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 344
           R L++ GA V    +    PLH+++  G  +I + L+++G  A  NA     + PLH  +
Sbjct: 483 RYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQG--ASPNAATTSGYTPLHLSA 540

Query: 345 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 404
           R GH D+  +LL     +   +    G TPLH+A   GK EVA  ++Q S +     ++ 
Sbjct: 541 REGHEDVAAFLLDHGASLS--ITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKS- 597

Query: 405 FSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNG 464
              T  H A  Y     +   LLDQ   + +   ++G+T LH A     + +   LL+ G
Sbjct: 598 -GLTPLHVAAHYDNQ-KVALLLLDQGA-SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG 654

Query: 465 ADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
           AD N V          +     +  A ++GH  +V+LL
Sbjct: 655 ADANAVT---------RQGIASVHLAAQEGHVDMVSLL 683



 Score =  150 bits (378), Expect = 7e-36
 Identities = 108/384 (28%), Positives = 177/384 (46%), Gaps = 51/384 (13%)

Query: 165 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 224
           TE+GL+ +H+    G   + +  LM  G  P+     G TALH+A     AE++  L+  
Sbjct: 430 TESGLTPIHVAAFMG-HVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488

Query: 225 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 284
           GA ++       T LHI+   G  +    LLQ GA+ N      +TPLH++A  GHE V 
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548

Query: 285 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 344
             LL  GA ++++ + G  PLH+A+  G L +A LL+++ +  D  A       PLH  +
Sbjct: 549 AFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD--AAGKSGLTPLHVAA 606

Query: 345 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQI-SGTESLTKEN 403
            + +  +   LL  D    PH     G TPLH+A    + ++A  +++  +   ++T++ 
Sbjct: 607 HYDNQKVALLLL--DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQG 664

Query: 404 IFSETAFHSACTYGKSIDLVKFLLDQNV-------------------------------- 431
           I S    H A   G  +D+V  LL +N                                 
Sbjct: 665 IAS---VHLAAQEG-HVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG 720

Query: 432 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAY 491
            +++ Q + G+T LH  C++G+I++V FLL + A +N         +  K+  T L  A 
Sbjct: 721 AHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN---------AKTKNGYTPLHQAA 771

Query: 492 EKGHDAIVTLLKHYKRPQDELPCN 515
           ++GH  I+ +L       +EL  N
Sbjct: 772 QQGHTHIINVLLQNNASPNELTVN 795



 Score =  145 bits (366), Expect = 2e-34
 Identities = 110/397 (27%), Positives = 182/397 (45%), Gaps = 33/397 (8%)

Query: 161 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 220
           +++   N ++ LH+     G  + ++ L+ +G +    TR+G T LH      + +++  
Sbjct: 261 VDFTARNDITPLHVASK-RGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEM 319

Query: 221 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 280
           LL   A I      GL+ LH+AT   HL    +LLQH   V+     + T LH+AA+ GH
Sbjct: 320 LLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGH 379

Query: 281 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPL 340
            +V ++LL   A+ N     G  PLH+A  K  + + +LL++ G  A + A       P+
Sbjct: 380 YKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHG--ASIQAVTESGLTPI 437

Query: 341 HFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESL 399
           H  +  GH +IV  L+       P+  N+ G+T LH+A  +G+ EV + ++Q     E+ 
Sbjct: 438 HVAAFMGHVNIVSQLMHHG--ASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAK 495

Query: 400 TKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQF 459
            K++   +T  H +   GK+ D+V+ LL Q   + N     G+T LH +   GH  +  F
Sbjct: 496 AKDD---QTPLHISARLGKA-DIVQQLLQQGA-SPNAATTSGYTPLHLSAREGHEDVAAF 550

Query: 460 LLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQ 519
           LLD+GA +++                      +KG   +    K+ K     L   + + 
Sbjct: 551 LLDHGASLSITT--------------------KKGFTPLHVAAKYGKLEVANLLLQKSAS 590

Query: 520 PGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSH 556
           P   G   S  +PL        +K  +LLL  G   H
Sbjct: 591 PDAAGK--SGLTPLHVAAHYDNQKVALLLLDQGASPH 625



 Score =  137 bits (345), Expect = 5e-32
 Identities = 106/318 (33%), Positives = 155/318 (48%), Gaps = 22/318 (6%)

Query: 200 RNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGA 259
           +NG  ALHLA  + + E+++ LL   A++      G TALHIA++AG  E   VL+ +GA
Sbjct: 72  QNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGA 131

Query: 260 NVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKL 319
           NVN Q    FTPL++AA   H +V + LL  GA  +++ E G  PL +A  +G   +  L
Sbjct: 132 NVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSL 191

Query: 320 LMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLAC 379
           L+E  +K  V          LH  +R         LLQ+D      V +  G TPLH+A 
Sbjct: 192 LLENDTKGKVRLP------ALHIAARKDDTKAAALLLQNDNNAD--VESKSGFTPLHIAA 243

Query: 380 YNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGR 439
           + G   VA  ++  +     T  N    T  H A   G + ++VK LLD+    I+ + R
Sbjct: 244 HYGNINVATLLLNRAAAVDFTARN--DITPLHVASKRGNA-NMVKLLLDRGA-KIDAKTR 299

Query: 440 DGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIV 499
           DG T LH     GH ++V+ LLD  A +          S  K+  + L  A +  H   V
Sbjct: 300 DGLTPLHCGARSGHEQVVEMLLDRAAPI---------LSKTKNGLSPLHMATQGDHLNCV 350

Query: 500 TLLKHYKRPQDELPCNEY 517
            LL  +  P D++  N+Y
Sbjct: 351 QLLLQHNVPVDDV-TNDY 367



 Score =  129 bits (323), Expect = 2e-29
 Identities = 101/346 (29%), Positives = 163/346 (47%), Gaps = 46/346 (13%)

Query: 159 VNLNYRTENGLSLLHLCCICGGKKSHIRT---LMLKGLRPSRLTRNGFTALHLAVYKDNA 215
           V++N   +NGL+ LHL      K+ H+     L+ +       T+ G TALH+A     A
Sbjct: 65  VDINICNQNGLNALHLA----SKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQA 120

Query: 216 ELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIA 275
           E++  L+ +GA++      G T L++A    HLE    LL +GA+ ++     FTPL +A
Sbjct: 121 EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180

Query: 276 AYYGHEQVTRLLLKFGA-----------------------------DVNVSGEVGDRPLH 306
              GH+QV  LLL+                                + +V  + G  PLH
Sbjct: 181 LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLH 240

Query: 307 LASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHV 366
           +A+  G +N+A LL+   +  D  A++  D  PLH  S+ G+ ++VK LL    ++    
Sbjct: 241 IAAHYGNINVATLLLNRAAAVDFTARN--DITPLHVASKRGNANMVKLLLDRGAKIDAKT 298

Query: 367 VNIYGDTPLHLACYNGKFEVAKEII-QISGTESLTKENIFSETAFHSACTYGKSIDLVKF 425
            +  G TPLH    +G  +V + ++ + +   S TK  +   +  H A T G  ++ V+ 
Sbjct: 299 RD--GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGL---SPLHMA-TQGDHLNCVQL 352

Query: 426 LLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVA 471
           LL  NV  ++    D  T LH A + GH ++ + LLD  A+ N  A
Sbjct: 353 LLQHNV-PVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKA 397



 Score =  123 bits (308), Expect = 9e-28
 Identities = 89/305 (29%), Positives = 147/305 (48%), Gaps = 19/305 (6%)

Query: 199 TRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHG 258
           +++GFT LH+A +  N  + T LL+  A +       +T LH+A+  G+     +LL  G
Sbjct: 232 SKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRG 291

Query: 259 ANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAK 318
           A ++ +     TPLH  A  GHEQV  +LL   A +    + G  PLH+A+    LN  +
Sbjct: 292 AKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQ 351

Query: 319 LLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLA 378
           LL++      V+   N+    LH  +  GH+ + K LL  D +  P+   + G TPLH+A
Sbjct: 352 LLLQH--NVPVDDVTNDYLTALHVAAHCGHYKVAKVLL--DKKANPNAKALNGFTPLHIA 407

Query: 379 CYNGKFEVAKEIIQISGT-ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQ 437
           C   + +V + +++   + +++T+  +   T  H A   G  +++V  L+     + N  
Sbjct: 408 CKKNRIKVMELLLKHGASIQAVTESGL---TPIHVAAFMG-HVNIVSQLMHHGA-SPNTT 462

Query: 438 GRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDA 497
              G T LH A   G   +V++L+ +GA +   A         KD+QT L  +   G   
Sbjct: 463 NVRGETALHMAARSGQAEVVRYLVQDGAQVEAKA---------KDDQTPLHISARLGKAD 513

Query: 498 IVTLL 502
           IV  L
Sbjct: 514 IVQQL 518



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 79/261 (30%), Positives = 129/261 (49%), Gaps = 21/261 (8%)

Query: 242 ATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVG 301
           A  AGHLE A   +++G ++NI +      LH+A+  GH +V   LL+  A+V+ + + G
Sbjct: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107

Query: 302 DRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLE 361
           +  LH+AS  G   + K+L+  G  A+VNAQ      PL+  ++  H ++VK+LL  D  
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNG--ANVNAQSQNGFTPLYMAAQENHLEVVKFLL--DNG 163

Query: 362 VQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSID 421
               +    G TPL +A   G  +V   ++     E+ TK  +    A H A    K   
Sbjct: 164 ASQSLATEDGFTPLAVALQQGHDQVVSLLL-----ENDTKGKV-RLPALHIAAR--KDDT 215

Query: 422 LVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEK 481
               LL QN  N + + + G T LH A ++G+I +   LL+  A ++  A         +
Sbjct: 216 KAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA---------R 266

Query: 482 DEQTCLMWAYEKGHDAIVTLL 502
           ++ T L  A ++G+  +V LL
Sbjct: 267 NDITPLHVASKRGNANMVKLL 287



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 50/181 (27%), Positives = 86/181 (47%), Gaps = 4/181 (2%)

Query: 162 NYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSL 221
           N  T  G++ +HL     G    +  L+ +    +   ++G T LHLA  +D   +   L
Sbjct: 658 NAVTRQGIASVHLAAQ-EGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVL 716

Query: 222 LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE 281
           ++ GA +      G T LH+    G+++  + LLQH A VN +    +TPLH AA  GH 
Sbjct: 717 VNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHT 776

Query: 282 QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIA---KLLMEEGSKADVNAQDNEDHV 338
            +  +LL+  A  N     G+  L +A   G++++    K++ EE        + ++ +V
Sbjct: 777 HIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNV 836

Query: 339 P 339
           P
Sbjct: 837 P 837


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  157 bits (398), Expect = 3e-38
 Identities = 108/336 (32%), Positives = 166/336 (49%), Gaps = 46/336 (13%)

Query: 164 RTENGLSLLHLCCICGGKKSHIRT---LMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 220
           +T++ L+ LH    C  +  H+R    L+  G      T+NG + +H+A   D+ + +  
Sbjct: 301 KTKDELTPLH----CAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 356

Query: 221 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 280
           LL   A+I  +    LT LH+A   GH   A VLL  GA  N +    FTPLHIA    H
Sbjct: 357 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 416

Query: 281 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEG---------------- 324
            +V  LLLK GA ++   E G  PLH+AS  G L I K L++ G                
Sbjct: 417 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 476

Query: 325 ---------------SKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 369
                          +KA VNA+  +D  PLH  +R GH ++VK LL+++    P++   
Sbjct: 477 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN--ANPNLATT 534

Query: 370 YGDTPLHLACYNGKFEVAKEIIQISGTES-LTKENIFSETAFHSACTYGKSIDLVKFLLD 428
            G TPLH+A   G  E    +++   +++ +TK+     T  H A  YGK + + + LL+
Sbjct: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF---TPLHVAAKYGK-VRVAELLLE 590

Query: 429 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNG 464
           ++  + N  G++G T LH A +H ++ +V+ LL  G
Sbjct: 591 RDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 625



 Score =  157 bits (397), Expect = 4e-38
 Identities = 120/373 (32%), Positives = 173/373 (46%), Gaps = 50/373 (13%)

Query: 165 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 224
           T + L+ LH+   CG  +   + L+ KG +P+    NGFT LH+A  K++  ++  LL +
Sbjct: 368 TLDHLTPLHVAAHCGHHRV-AKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 426

Query: 225 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 284
           GA I  V   GLT LH+A+  GHL     LLQ GA+ N+ +    TPLH+AA  GH +V 
Sbjct: 427 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 486

Query: 285 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 344
           + LL+  A VN   +    PLH A+  G  N+ KLL+E  + A+ N      H PLH  +
Sbjct: 487 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE--NNANPNLATTAGHTPLHIAA 544

Query: 345 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 404
           R GH + V  LL+   E     +   G TPLH+A   GK  VA+ +++     +   +N 
Sbjct: 545 REGHVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN- 601

Query: 405 FSETAFHSACTYGKSIDLVKFLL---------------------DQNVINI--------- 434
              T  H A  +  ++D+VK LL                      QN + +         
Sbjct: 602 -GLTPLHVA-VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 659

Query: 435 --NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYE 492
             N +   G T LH A   GH  +V  LL   A+ NL         G K   T L    +
Sbjct: 660 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---------GNKSGLTPLHLVAQ 710

Query: 493 KGHDAIV-TLLKH 504
           +GH  +   L+KH
Sbjct: 711 EGHVPVADVLIKH 723



 Score =  154 bits (388), Expect = 5e-37
 Identities = 104/306 (33%), Positives = 156/306 (50%), Gaps = 9/306 (2%)

Query: 160 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 219
           ++N+  +NG++ LH+     G    +R L+ +G +    T++  T LH A    +  +  
Sbjct: 264 SVNFTPQNGITPLHIASR-RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 322

Query: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279
            LL  GA IQ     GL+ +H+A    HL+   +LLQ+ A ++       TPLH+AA+ G
Sbjct: 323 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 382

Query: 280 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 339
           H +V ++LL  GA  N     G  PLH+A  K  + + +LL++ G  A ++A       P
Sbjct: 383 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG--ASIDAVTESGLTP 440

Query: 340 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESL 399
           LH  S  GH  IVK LLQ      P+V N+  +TPLH+A   G  EVAK ++Q     + 
Sbjct: 441 LHVASFMGHLPIVKNLLQRG--ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 498

Query: 400 TKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQF 459
             ++   +T  H A   G + ++VK LL+ N  N N     GHT LH A   GH+  V  
Sbjct: 499 KAKD--DQTPLHCAARIGHT-NMVKLLLENNA-NPNLATTAGHTPLHIAAREGHVETVLA 554

Query: 460 LLDNGA 465
           LL+  A
Sbjct: 555 LLEKEA 560



 Score =  141 bits (355), Expect = 3e-33
 Identities = 96/341 (28%), Positives = 160/341 (46%), Gaps = 38/341 (11%)

Query: 161 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKG-LRPSRLTRNGFTALHLAVYKDNAELIT 219
           +NY T+  + L  L        +    ++L+    P  L++ GFT LH+A + +N  +  
Sbjct: 197 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 256

Query: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279
            LL+ GA +      G+T LHIA+  G++    +LL  GA +  +     TPLH AA  G
Sbjct: 257 LLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNG 316

Query: 280 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 339
           H +++ +LL  GA +    + G  P+H+A+    L+  +LL++  ++ D    D+    P
Sbjct: 317 HVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--LTP 374

Query: 340 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY----------------------------- 370
           LH  +  GHH + K LL    +     +N +                             
Sbjct: 375 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 434

Query: 371 --GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD 428
             G TPLH+A + G   + K ++Q   + +++  N+  ET  H A   G + ++ K+LL 
Sbjct: 435 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPLHMAARAGHT-EVAKYLL- 490

Query: 429 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 469
           QN   +N + +D  T LH A   GH  +V+ LL+N A+ NL
Sbjct: 491 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 531



 Score =  140 bits (353), Expect = 6e-33
 Identities = 118/407 (28%), Positives = 182/407 (44%), Gaps = 84/407 (20%)

Query: 162 NYRTENGLSLLHLCCICGGKKSHIRT--LMLK-GLRPSRLTRNGFTALHLAVYKDNAELI 218
           N R  NG + LH+ C    KK+H+R   L+LK G     +T +G T LH+A +  +  ++
Sbjct: 398 NSRALNGFTPLHIAC----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 453

Query: 219 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 278
            +LL  GA          T LH+A  AGH E A  LLQ+ A VN +     TPLH AA  
Sbjct: 454 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 513

Query: 279 GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHV 338
           GH  + +LLL+  A+ N++   G  PLH+A+ +G +     L+E+  +A       +   
Sbjct: 514 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK--EASQACMTKKGFT 571

Query: 339 PLHFCSRFGHHDIVKYLLQSD----------------------LEV---------QPHVV 367
           PLH  +++G   + + LL+ D                      L++          PH  
Sbjct: 572 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 631

Query: 368 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL 427
              G TPLH+A    + EVA+ ++Q  G  S   E++   T  H A   G + ++V  LL
Sbjct: 632 AWNGYTPLHIAAKQNQVEVARSLLQYGG--SANAESVQGVTPLHLAAQEGHA-EMVALLL 688

Query: 428 DQNV--------------------------------ININHQGRDGHTGLHSACYHGHIR 455
            +                                  + ++   R G+T LH A ++G+I+
Sbjct: 689 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 748

Query: 456 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
           LV+FLL + AD+N         +  K   + L  A ++GH  IVTLL
Sbjct: 749 LVKFLLQHQADVN---------AKTKLGYSPLHQAAQQGHTDIVTLL 786



 Score =  140 bits (352), Expect = 7e-33
 Identities = 98/317 (30%), Positives = 157/317 (49%), Gaps = 9/317 (2%)

Query: 157 SKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAE 216
           +K  +N + ++  + LH C    G  + ++ L+     P+  T  G T LH+A  + + E
Sbjct: 492 NKAKVNAKAKDDQTPLH-CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 550

Query: 217 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 276
            + +LL   A    +   G T LH+A   G +  A++LL+  A+ N       TPLH+A 
Sbjct: 551 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 610

Query: 277 YYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 336
           ++ +  + +LLL  G   +     G  PLH+A+ +  + +A+ L++ G  A  NA+  + 
Sbjct: 611 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQG 668

Query: 337 HVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGT 396
             PLH  ++ GH ++V  LL    +   ++ N  G TPLHL    G   VA  +I+    
Sbjct: 669 VTPLHLAAQEGHAEMVALLLSK--QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 726

Query: 397 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 456
              T       T  H A  YG +I LVKFLL Q+  ++N + + G++ LH A   GH  +
Sbjct: 727 VDATTR--MGYTPLHVASHYG-NIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDI 782

Query: 457 VQFLLDNGADMNLVACD 473
           V  LL NGA  N V+ D
Sbjct: 783 VTLLLKNGASPNEVSSD 799



 Score =  136 bits (343), Expect = 8e-32
 Identities = 94/274 (34%), Positives = 141/274 (51%), Gaps = 12/274 (4%)

Query: 192 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAA 251
           G+  +   +NG   LHLA  + + +++  LLH    ++     G TALHIA +AG  E  
Sbjct: 68  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 127

Query: 252 DVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAK 311
             L+ +GANVN Q    FTPL++AA   H +V + LL+ GA+ NV+ E G  PL +A  +
Sbjct: 128 RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 187

Query: 312 GFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYG 371
           G  N+   L+  G+K  V          LH  +R         LLQ+D    P V++  G
Sbjct: 188 GHENVVAHLINYGTKGKVRLP------ALHIAARNDDTRTAAVLLQND--PNPDVLSKTG 239

Query: 372 DTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNV 431
            TPLH+A +     VA+ ++    + + T +N    T  H A   G  I +V+ LLD+  
Sbjct: 240 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASRRGNVI-MVRLLLDRGA 296

Query: 432 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGA 465
             I  + +D  T LH A  +GH+R+ + LLD+GA
Sbjct: 297 -QIETKTKDELTPLHCAARNGHVRISEILLDHGA 329



 Score =  136 bits (342), Expect = 1e-31
 Identities = 102/343 (29%), Positives = 170/343 (49%), Gaps = 40/343 (11%)

Query: 158 KVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAEL 217
           ++ L   T+ G + LH+  + G +   +R L+  G   +  ++ GFT L++A  +++ E+
Sbjct: 101 EIILETTTKKGNTALHIAALAG-QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 159

Query: 218 ITSLLHSGAD---------------IQQ---------VGYG-----GLTALHIATIAGHL 248
           +  LL +GA+               +QQ         + YG      L ALHIA      
Sbjct: 160 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 219

Query: 249 EAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLA 308
             A VLLQ+  N ++     FTPLHIAA+Y +  V +LLL  GA VN + + G  PLH+A
Sbjct: 220 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 279

Query: 309 SAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVN 368
           S +G + + +LL++ G++ +   +D  +  PLH  +R GH  I + LL     +Q    N
Sbjct: 280 SRRGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337

Query: 369 IYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFSETAFHSACTYGKSIDLVKFLL 427
             G +P+H+A      +  + ++Q     + +T +++   T  H A   G    + K LL
Sbjct: 338 --GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHH-RVAKVLL 391

Query: 428 DQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLV 470
           D+     N +  +G T LH AC   H+R+++ LL  GA ++ V
Sbjct: 392 DKGA-KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 433



 Score =  129 bits (323), Expect = 2e-29
 Identities = 107/362 (29%), Positives = 164/362 (45%), Gaps = 55/362 (15%)

Query: 140 EKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIR---TLMLKGLRPS 196
           +K L  LRN          V++N   +NGL+ LHL      K+ H++    L+ K +   
Sbjct: 59  DKALDHLRN---------GVDINTCNQNGLNGLHL----ASKEGHVKMVVELLHKEIILE 105

Query: 197 RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQ 256
             T+ G TALH+A      E++  L++ GA++      G T L++A    HLE    LL+
Sbjct: 106 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 165

Query: 257 HGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA------------------------ 292
           +GAN N+     FTPL +A   GHE V   L+ +G                         
Sbjct: 166 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 225

Query: 293 -----DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 347
                + +V  + G  PLH+A+    LN+A+LL+  G  A VN        PLH  SR G
Sbjct: 226 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG--ASVNFTPQNGITPLHIASRRG 283

Query: 348 HHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFS 406
           +  +V+ LL    +++    +    TPLH A  NG   +++ ++      ++ TK  +  
Sbjct: 284 NVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-- 339

Query: 407 ETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGAD 466
            +  H A   G  +D V+ LL  +   I+    D  T LH A + GH R+ + LLD GA 
Sbjct: 340 -SPIHMA-AQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 396

Query: 467 MN 468
            N
Sbjct: 397 PN 398



 Score =  124 bits (310), Expect = 5e-28
 Identities = 79/266 (29%), Positives = 132/266 (49%), Gaps = 7/266 (2%)

Query: 165 TENGLSLLHLCCICGGKKSHIRTLML-KGLRPSRLTRNGFTALHLAVYKDNAELITSLLH 223
           T+ G + LH+    G  K  +  L+L +   P+   +NG T LH+AV+ +N +++  LL 
Sbjct: 566 TKKGFTPLHVAAKYG--KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 623

Query: 224 SGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQV 283
            G       + G T LHIA     +E A  LLQ+G + N +     TPLH+AA  GH ++
Sbjct: 624 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 683

Query: 284 TRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFC 343
             LLL   A+ N+  + G  PLHL + +G + +A +L++ G   D  A     + PLH  
Sbjct: 684 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD--ATTRMGYTPLHVA 741

Query: 344 SRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKEN 403
           S +G+  +VK+LLQ   +V  +     G +PLH A   G  ++   +++   + +    +
Sbjct: 742 SHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 799

Query: 404 IFSETAFHSACTYGKSIDLVKFLLDQ 429
             +  A      Y    D++K + D+
Sbjct: 800 GTTPLAIAKRLGYISVTDVLKVVTDE 825



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 54/210 (25%), Positives = 86/210 (40%), Gaps = 54/210 (25%)

Query: 302 DRPLHLASAKGFL------NIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYL 355
           DR     +A  FL      N+ K L    +  D+N  +      LH  S+ GH  +V  L
Sbjct: 38  DRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 97

Query: 356 LQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACT 415
           L  ++ ++       G+T LH+A   G+ EV +E++                        
Sbjct: 98  LHKEIILETTTKK--GNTALHIAALAGQDEVVRELVN----------------------- 132

Query: 416 YGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPS 475
           YG               N+N Q + G T L+ A    H+ +V+FLL+NGA+ N+      
Sbjct: 133 YGA--------------NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT---- 174

Query: 476 RSSGEKDEQTCLMWAYEKGHDAIVTLLKHY 505
                +D  T L  A ++GH+ +V  L +Y
Sbjct: 175 -----EDGFTPLAVALQQGHENVVAHLINY 199


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  157 bits (398), Expect = 3e-38
 Identities = 108/336 (32%), Positives = 166/336 (49%), Gaps = 46/336 (13%)

Query: 164 RTENGLSLLHLCCICGGKKSHIRT---LMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 220
           +T++ L+ LH    C  +  H+R    L+  G      T+NG + +H+A   D+ + +  
Sbjct: 268 KTKDELTPLH----CAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 221 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 280
           LL   A+I  +    LT LH+A   GH   A VLL  GA  N +    FTPLHIA    H
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383

Query: 281 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEG---------------- 324
            +V  LLLK GA ++   E G  PLH+AS  G L I K L++ G                
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443

Query: 325 ---------------SKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 369
                          +KA VNA+  +D  PLH  +R GH ++VK LL+++    P++   
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN--ANPNLATT 501

Query: 370 YGDTPLHLACYNGKFEVAKEIIQISGTES-LTKENIFSETAFHSACTYGKSIDLVKFLLD 428
            G TPLH+A   G  E    +++   +++ +TK+     T  H A  YGK + + + LL+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF---TPLHVAAKYGK-VRVAELLLE 557

Query: 429 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNG 464
           ++  + N  G++G T LH A +H ++ +V+ LL  G
Sbjct: 558 RDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592



 Score =  157 bits (397), Expect = 4e-38
 Identities = 120/373 (32%), Positives = 173/373 (46%), Gaps = 50/373 (13%)

Query: 165 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 224
           T + L+ LH+   CG  +   + L+ KG +P+    NGFT LH+A  K++  ++  LL +
Sbjct: 335 TLDHLTPLHVAAHCGHHRV-AKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393

Query: 225 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 284
           GA I  V   GLT LH+A+  GHL     LLQ GA+ N+ +    TPLH+AA  GH +V 
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453

Query: 285 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 344
           + LL+  A VN   +    PLH A+  G  N+ KLL+E  + A+ N      H PLH  +
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE--NNANPNLATTAGHTPLHIAA 511

Query: 345 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 404
           R GH + V  LL+   E     +   G TPLH+A   GK  VA+ +++     +   +N 
Sbjct: 512 REGHVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN- 568

Query: 405 FSETAFHSACTYGKSIDLVKFLL---------------------DQNVINI--------- 434
              T  H A  +  ++D+VK LL                      QN + +         
Sbjct: 569 -GLTPLHVA-VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626

Query: 435 --NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYE 492
             N +   G T LH A   GH  +V  LL   A+ NL         G K   T L    +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---------GNKSGLTPLHLVAQ 677

Query: 493 KGHDAIV-TLLKH 504
           +GH  +   L+KH
Sbjct: 678 EGHVPVADVLIKH 690



 Score =  154 bits (388), Expect = 5e-37
 Identities = 104/306 (33%), Positives = 156/306 (50%), Gaps = 9/306 (2%)

Query: 160 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 219
           ++N+  +NG++ LH+     G    +R L+ +G +    T++  T LH A    +  +  
Sbjct: 231 SVNFTPQNGITPLHIASR-RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289

Query: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279
            LL  GA IQ     GL+ +H+A    HL+   +LLQ+ A ++       TPLH+AA+ G
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349

Query: 280 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 339
           H +V ++LL  GA  N     G  PLH+A  K  + + +LL++ G  A ++A       P
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG--ASIDAVTESGLTP 407

Query: 340 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESL 399
           LH  S  GH  IVK LLQ      P+V N+  +TPLH+A   G  EVAK ++Q     + 
Sbjct: 408 LHVASFMGHLPIVKNLLQRG--ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465

Query: 400 TKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQF 459
             ++   +T  H A   G + ++VK LL+ N  N N     GHT LH A   GH+  V  
Sbjct: 466 KAKD--DQTPLHCAARIGHT-NMVKLLLENNA-NPNLATTAGHTPLHIAAREGHVETVLA 521

Query: 460 LLDNGA 465
           LL+  A
Sbjct: 522 LLEKEA 527



 Score =  141 bits (355), Expect = 3e-33
 Identities = 96/341 (28%), Positives = 160/341 (46%), Gaps = 38/341 (11%)

Query: 161 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKG-LRPSRLTRNGFTALHLAVYKDNAELIT 219
           +NY T+  + L  L        +    ++L+    P  L++ GFT LH+A + +N  +  
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223

Query: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279
            LL+ GA +      G+T LHIA+  G++    +LL  GA +  +     TPLH AA  G
Sbjct: 224 LLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNG 283

Query: 280 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 339
           H +++ +LL  GA +    + G  P+H+A+    L+  +LL++  ++ D    D+    P
Sbjct: 284 HVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--LTP 341

Query: 340 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY----------------------------- 370
           LH  +  GHH + K LL    +     +N +                             
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 371 --GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD 428
             G TPLH+A + G   + K ++Q   + +++  N+  ET  H A   G + ++ K+LL 
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPLHMAARAGHT-EVAKYLL- 457

Query: 429 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 469
           QN   +N + +D  T LH A   GH  +V+ LL+N A+ NL
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498



 Score =  140 bits (353), Expect = 6e-33
 Identities = 118/407 (28%), Positives = 182/407 (44%), Gaps = 84/407 (20%)

Query: 162 NYRTENGLSLLHLCCICGGKKSHIRT--LMLK-GLRPSRLTRNGFTALHLAVYKDNAELI 218
           N R  NG + LH+ C    KK+H+R   L+LK G     +T +G T LH+A +  +  ++
Sbjct: 365 NSRALNGFTPLHIAC----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 219 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 278
            +LL  GA          T LH+A  AGH E A  LLQ+ A VN +     TPLH AA  
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 279 GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHV 338
           GH  + +LLL+  A+ N++   G  PLH+A+ +G +     L+E+  +A       +   
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK--EASQACMTKKGFT 538

Query: 339 PLHFCSRFGHHDIVKYLLQSD----------------------LEV---------QPHVV 367
           PLH  +++G   + + LL+ D                      L++          PH  
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598

Query: 368 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL 427
              G TPLH+A    + EVA+ ++Q  G  S   E++   T  H A   G + ++V  LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGG--SANAESVQGVTPLHLAAQEGHA-EMVALLL 655

Query: 428 DQNV--------------------------------ININHQGRDGHTGLHSACYHGHIR 455
            +                                  + ++   R G+T LH A ++G+I+
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715

Query: 456 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
           LV+FLL + AD+N         +  K   + L  A ++GH  IVTLL
Sbjct: 716 LVKFLLQHQADVN---------AKTKLGYSPLHQAAQQGHTDIVTLL 753



 Score =  140 bits (352), Expect = 7e-33
 Identities = 98/317 (30%), Positives = 157/317 (49%), Gaps = 9/317 (2%)

Query: 157 SKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAE 216
           +K  +N + ++  + LH C    G  + ++ L+     P+  T  G T LH+A  + + E
Sbjct: 459 NKAKVNAKAKDDQTPLH-CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517

Query: 217 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 276
            + +LL   A    +   G T LH+A   G +  A++LL+  A+ N       TPLH+A 
Sbjct: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577

Query: 277 YYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 336
           ++ +  + +LLL  G   +     G  PLH+A+ +  + +A+ L++ G  A  NA+  + 
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQG 635

Query: 337 HVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGT 396
             PLH  ++ GH ++V  LL    +   ++ N  G TPLHL    G   VA  +I+    
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSK--QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 397 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 456
              T       T  H A  YG +I LVKFLL Q+  ++N + + G++ LH A   GH  +
Sbjct: 694 VDATTR--MGYTPLHVASHYG-NIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDI 749

Query: 457 VQFLLDNGADMNLVACD 473
           V  LL NGA  N V+ D
Sbjct: 750 VTLLLKNGASPNEVSSD 766



 Score =  136 bits (343), Expect = 8e-32
 Identities = 94/274 (34%), Positives = 141/274 (51%), Gaps = 12/274 (4%)

Query: 192 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAA 251
           G+  +   +NG   LHLA  + + +++  LLH    ++     G TALHIA +AG  E  
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 252 DVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAK 311
             L+ +GANVN Q    FTPL++AA   H +V + LL+ GA+ NV+ E G  PL +A  +
Sbjct: 95  RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154

Query: 312 GFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYG 371
           G  N+   L+  G+K  V          LH  +R         LLQ+D    P V++  G
Sbjct: 155 GHENVVAHLINYGTKGKVRLP------ALHIAARNDDTRTAAVLLQND--PNPDVLSKTG 206

Query: 372 DTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNV 431
            TPLH+A +     VA+ ++    + + T +N    T  H A   G  I +V+ LLD+  
Sbjct: 207 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASRRGNVI-MVRLLLDRGA 263

Query: 432 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGA 465
             I  + +D  T LH A  +GH+R+ + LLD+GA
Sbjct: 264 -QIETKTKDELTPLHCAARNGHVRISEILLDHGA 296



 Score =  136 bits (342), Expect = 1e-31
 Identities = 102/343 (29%), Positives = 170/343 (49%), Gaps = 40/343 (11%)

Query: 158 KVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAEL 217
           ++ L   T+ G + LH+  + G +   +R L+  G   +  ++ GFT L++A  +++ E+
Sbjct: 68  EIILETTTKKGNTALHIAALAG-QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126

Query: 218 ITSLLHSGAD---------------IQQ---------VGYG-----GLTALHIATIAGHL 248
           +  LL +GA+               +QQ         + YG      L ALHIA      
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186

Query: 249 EAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLA 308
             A VLLQ+  N ++     FTPLHIAA+Y +  V +LLL  GA VN + + G  PLH+A
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246

Query: 309 SAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVN 368
           S +G + + +LL++ G++ +   +D  +  PLH  +R GH  I + LL     +Q    N
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304

Query: 369 IYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFSETAFHSACTYGKSIDLVKFLL 427
             G +P+H+A      +  + ++Q     + +T +++   T  H A   G    + K LL
Sbjct: 305 --GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHH-RVAKVLL 358

Query: 428 DQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLV 470
           D+     N +  +G T LH AC   H+R+++ LL  GA ++ V
Sbjct: 359 DKGA-KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400



 Score =  129 bits (323), Expect = 2e-29
 Identities = 107/362 (29%), Positives = 164/362 (45%), Gaps = 55/362 (15%)

Query: 140 EKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIR---TLMLKGLRPS 196
           +K L  LRN          V++N   +NGL+ LHL      K+ H++    L+ K +   
Sbjct: 26  DKALDHLRN---------GVDINTCNQNGLNGLHL----ASKEGHVKMVVELLHKEIILE 72

Query: 197 RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQ 256
             T+ G TALH+A      E++  L++ GA++      G T L++A    HLE    LL+
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 257 HGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA------------------------ 292
           +GAN N+     FTPL +A   GHE V   L+ +G                         
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 293 -----DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 347
                + +V  + G  PLH+A+    LN+A+LL+  G  A VN        PLH  SR G
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG--ASVNFTPQNGITPLHIASRRG 250

Query: 348 HHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFS 406
           +  +V+ LL    +++    +    TPLH A  NG   +++ ++      ++ TK  +  
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-- 306

Query: 407 ETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGAD 466
            +  H A   G  +D V+ LL  +   I+    D  T LH A + GH R+ + LLD GA 
Sbjct: 307 -SPIHMA-AQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363

Query: 467 MN 468
            N
Sbjct: 364 PN 365



 Score =  124 bits (310), Expect = 5e-28
 Identities = 79/266 (29%), Positives = 132/266 (49%), Gaps = 7/266 (2%)

Query: 165 TENGLSLLHLCCICGGKKSHIRTLML-KGLRPSRLTRNGFTALHLAVYKDNAELITSLLH 223
           T+ G + LH+    G  K  +  L+L +   P+   +NG T LH+AV+ +N +++  LL 
Sbjct: 533 TKKGFTPLHVAAKYG--KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 224 SGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQV 283
            G       + G T LHIA     +E A  LLQ+G + N +     TPLH+AA  GH ++
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650

Query: 284 TRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFC 343
             LLL   A+ N+  + G  PLHL + +G + +A +L++ G   D  A     + PLH  
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD--ATTRMGYTPLHVA 708

Query: 344 SRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKEN 403
           S +G+  +VK+LLQ   +V  +     G +PLH A   G  ++   +++   + +    +
Sbjct: 709 SHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766

Query: 404 IFSETAFHSACTYGKSIDLVKFLLDQ 429
             +  A      Y    D++K + D+
Sbjct: 767 GTTPLAIAKRLGYISVTDVLKVVTDE 792



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 49/191 (25%), Positives = 80/191 (41%), Gaps = 48/191 (25%)

Query: 315 NIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTP 374
           N+ K L    +  D+N  +      LH  S+ GH  +V  LL  ++ ++       G+T 
Sbjct: 24  NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK--GNTA 81

Query: 375 LHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVINI 434
           LH+A   G+ EV +E++                        YG               N+
Sbjct: 82  LHIAALAGQDEVVRELVN-----------------------YGA--------------NV 104

Query: 435 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 494
           N Q + G T L+ A    H+ +V+FLL+NGA+ N+           +D  T L  A ++G
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT---------EDGFTPLAVALQQG 155

Query: 495 HDAIVTLLKHY 505
           H+ +V  L +Y
Sbjct: 156 HENVVAHLINY 166


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  157 bits (398), Expect = 3e-38
 Identities = 108/336 (32%), Positives = 166/336 (49%), Gaps = 46/336 (13%)

Query: 164 RTENGLSLLHLCCICGGKKSHIRT---LMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 220
           +T++ L+ LH    C  +  H+R    L+  G      T+NG + +H+A   D+ + +  
Sbjct: 268 KTKDELTPLH----CAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 221 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 280
           LL   A+I  +    LT LH+A   GH   A VLL  GA  N +    FTPLHIA    H
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383

Query: 281 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEG---------------- 324
            +V  LLLK GA ++   E G  PLH+AS  G L I K L++ G                
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443

Query: 325 ---------------SKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 369
                          +KA VNA+  +D  PLH  +R GH ++VK LL+++    P++   
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN--ANPNLATT 501

Query: 370 YGDTPLHLACYNGKFEVAKEIIQISGTES-LTKENIFSETAFHSACTYGKSIDLVKFLLD 428
            G TPLH+A   G  E    +++   +++ +TK+     T  H A  YGK + + + LL+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF---TPLHVAAKYGK-VRVAELLLE 557

Query: 429 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNG 464
           ++  + N  G++G T LH A +H ++ +V+ LL  G
Sbjct: 558 RDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592



 Score =  157 bits (397), Expect = 4e-38
 Identities = 120/373 (32%), Positives = 173/373 (46%), Gaps = 50/373 (13%)

Query: 165 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 224
           T + L+ LH+   CG  +   + L+ KG +P+    NGFT LH+A  K++  ++  LL +
Sbjct: 335 TLDHLTPLHVAAHCGHHRV-AKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393

Query: 225 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 284
           GA I  V   GLT LH+A+  GHL     LLQ GA+ N+ +    TPLH+AA  GH +V 
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453

Query: 285 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 344
           + LL+  A VN   +    PLH A+  G  N+ KLL+E  + A+ N      H PLH  +
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE--NNANPNLATTAGHTPLHIAA 511

Query: 345 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 404
           R GH + V  LL+   E     +   G TPLH+A   GK  VA+ +++     +   +N 
Sbjct: 512 REGHVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN- 568

Query: 405 FSETAFHSACTYGKSIDLVKFLL---------------------DQNVINI--------- 434
              T  H A  +  ++D+VK LL                      QN + +         
Sbjct: 569 -GLTPLHVA-VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626

Query: 435 --NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYE 492
             N +   G T LH A   GH  +V  LL   A+ NL         G K   T L    +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---------GNKSGLTPLHLVAQ 677

Query: 493 KGHDAIV-TLLKH 504
           +GH  +   L+KH
Sbjct: 678 EGHVPVADVLIKH 690



 Score =  154 bits (388), Expect = 5e-37
 Identities = 104/306 (33%), Positives = 156/306 (50%), Gaps = 9/306 (2%)

Query: 160 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 219
           ++N+  +NG++ LH+     G    +R L+ +G +    T++  T LH A    +  +  
Sbjct: 231 SVNFTPQNGITPLHIASR-RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289

Query: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279
            LL  GA IQ     GL+ +H+A    HL+   +LLQ+ A ++       TPLH+AA+ G
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349

Query: 280 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 339
           H +V ++LL  GA  N     G  PLH+A  K  + + +LL++ G  A ++A       P
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG--ASIDAVTESGLTP 407

Query: 340 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESL 399
           LH  S  GH  IVK LLQ      P+V N+  +TPLH+A   G  EVAK ++Q     + 
Sbjct: 408 LHVASFMGHLPIVKNLLQRG--ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465

Query: 400 TKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQF 459
             ++   +T  H A   G + ++VK LL+ N  N N     GHT LH A   GH+  V  
Sbjct: 466 KAKD--DQTPLHCAARIGHT-NMVKLLLENNA-NPNLATTAGHTPLHIAAREGHVETVLA 521

Query: 460 LLDNGA 465
           LL+  A
Sbjct: 522 LLEKEA 527



 Score =  141 bits (355), Expect = 3e-33
 Identities = 96/341 (28%), Positives = 160/341 (46%), Gaps = 38/341 (11%)

Query: 161 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKG-LRPSRLTRNGFTALHLAVYKDNAELIT 219
           +NY T+  + L  L        +    ++L+    P  L++ GFT LH+A + +N  +  
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223

Query: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279
            LL+ GA +      G+T LHIA+  G++    +LL  GA +  +     TPLH AA  G
Sbjct: 224 LLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNG 283

Query: 280 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 339
           H +++ +LL  GA +    + G  P+H+A+    L+  +LL++  ++ D    D+    P
Sbjct: 284 HVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--LTP 341

Query: 340 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY----------------------------- 370
           LH  +  GHH + K LL    +     +N +                             
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 371 --GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD 428
             G TPLH+A + G   + K ++Q   + +++  N+  ET  H A   G + ++ K+LL 
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPLHMAARAGHT-EVAKYLL- 457

Query: 429 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 469
           QN   +N + +D  T LH A   GH  +V+ LL+N A+ NL
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498



 Score =  140 bits (353), Expect = 6e-33
 Identities = 118/407 (28%), Positives = 182/407 (44%), Gaps = 84/407 (20%)

Query: 162 NYRTENGLSLLHLCCICGGKKSHIRT--LMLK-GLRPSRLTRNGFTALHLAVYKDNAELI 218
           N R  NG + LH+ C    KK+H+R   L+LK G     +T +G T LH+A +  +  ++
Sbjct: 365 NSRALNGFTPLHIAC----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 219 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 278
            +LL  GA          T LH+A  AGH E A  LLQ+ A VN +     TPLH AA  
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 279 GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHV 338
           GH  + +LLL+  A+ N++   G  PLH+A+ +G +     L+E+  +A       +   
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK--EASQACMTKKGFT 538

Query: 339 PLHFCSRFGHHDIVKYLLQSD----------------------LEV---------QPHVV 367
           PLH  +++G   + + LL+ D                      L++          PH  
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598

Query: 368 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL 427
              G TPLH+A    + EVA+ ++Q  G  S   E++   T  H A   G + ++V  LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGG--SANAESVQGVTPLHLAAQEGHA-EMVALLL 655

Query: 428 DQNV--------------------------------ININHQGRDGHTGLHSACYHGHIR 455
            +                                  + ++   R G+T LH A ++G+I+
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715

Query: 456 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
           LV+FLL + AD+N         +  K   + L  A ++GH  IVTLL
Sbjct: 716 LVKFLLQHQADVN---------AKTKLGYSPLHQAAQQGHTDIVTLL 753



 Score =  140 bits (352), Expect = 7e-33
 Identities = 98/317 (30%), Positives = 157/317 (49%), Gaps = 9/317 (2%)

Query: 157 SKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAE 216
           +K  +N + ++  + LH C    G  + ++ L+     P+  T  G T LH+A  + + E
Sbjct: 459 NKAKVNAKAKDDQTPLH-CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517

Query: 217 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 276
            + +LL   A    +   G T LH+A   G +  A++LL+  A+ N       TPLH+A 
Sbjct: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577

Query: 277 YYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 336
           ++ +  + +LLL  G   +     G  PLH+A+ +  + +A+ L++ G  A  NA+  + 
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQG 635

Query: 337 HVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGT 396
             PLH  ++ GH ++V  LL    +   ++ N  G TPLHL    G   VA  +I+    
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSK--QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 397 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 456
              T       T  H A  YG +I LVKFLL Q+  ++N + + G++ LH A   GH  +
Sbjct: 694 VDATTR--MGYTPLHVASHYG-NIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDI 749

Query: 457 VQFLLDNGADMNLVACD 473
           V  LL NGA  N V+ D
Sbjct: 750 VTLLLKNGASPNEVSSD 766



 Score =  136 bits (343), Expect = 8e-32
 Identities = 94/274 (34%), Positives = 141/274 (51%), Gaps = 12/274 (4%)

Query: 192 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAA 251
           G+  +   +NG   LHLA  + + +++  LLH    ++     G TALHIA +AG  E  
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 252 DVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAK 311
             L+ +GANVN Q    FTPL++AA   H +V + LL+ GA+ NV+ E G  PL +A  +
Sbjct: 95  RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154

Query: 312 GFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYG 371
           G  N+   L+  G+K  V          LH  +R         LLQ+D    P V++  G
Sbjct: 155 GHENVVAHLINYGTKGKVRLP------ALHIAARNDDTRTAAVLLQND--PNPDVLSKTG 206

Query: 372 DTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNV 431
            TPLH+A +     VA+ ++    + + T +N    T  H A   G  I +V+ LLD+  
Sbjct: 207 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASRRGNVI-MVRLLLDRGA 263

Query: 432 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGA 465
             I  + +D  T LH A  +GH+R+ + LLD+GA
Sbjct: 264 -QIETKTKDELTPLHCAARNGHVRISEILLDHGA 296



 Score =  136 bits (342), Expect = 1e-31
 Identities = 102/343 (29%), Positives = 170/343 (49%), Gaps = 40/343 (11%)

Query: 158 KVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAEL 217
           ++ L   T+ G + LH+  + G +   +R L+  G   +  ++ GFT L++A  +++ E+
Sbjct: 68  EIILETTTKKGNTALHIAALAG-QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126

Query: 218 ITSLLHSGAD---------------IQQ---------VGYG-----GLTALHIATIAGHL 248
           +  LL +GA+               +QQ         + YG      L ALHIA      
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186

Query: 249 EAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLA 308
             A VLLQ+  N ++     FTPLHIAA+Y +  V +LLL  GA VN + + G  PLH+A
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246

Query: 309 SAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVN 368
           S +G + + +LL++ G++ +   +D  +  PLH  +R GH  I + LL     +Q    N
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304

Query: 369 IYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFSETAFHSACTYGKSIDLVKFLL 427
             G +P+H+A      +  + ++Q     + +T +++   T  H A   G    + K LL
Sbjct: 305 --GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHH-RVAKVLL 358

Query: 428 DQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLV 470
           D+     N +  +G T LH AC   H+R+++ LL  GA ++ V
Sbjct: 359 DKGA-KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400



 Score =  129 bits (323), Expect = 2e-29
 Identities = 107/362 (29%), Positives = 164/362 (45%), Gaps = 55/362 (15%)

Query: 140 EKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIR---TLMLKGLRPS 196
           +K L  LRN          V++N   +NGL+ LHL      K+ H++    L+ K +   
Sbjct: 26  DKALDHLRN---------GVDINTCNQNGLNGLHL----ASKEGHVKMVVELLHKEIILE 72

Query: 197 RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQ 256
             T+ G TALH+A      E++  L++ GA++      G T L++A    HLE    LL+
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 257 HGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA------------------------ 292
           +GAN N+     FTPL +A   GHE V   L+ +G                         
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 293 -----DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 347
                + +V  + G  PLH+A+    LN+A+LL+  G  A VN        PLH  SR G
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG--ASVNFTPQNGITPLHIASRRG 250

Query: 348 HHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFS 406
           +  +V+ LL    +++    +    TPLH A  NG   +++ ++      ++ TK  +  
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-- 306

Query: 407 ETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGAD 466
            +  H A   G  +D V+ LL  +   I+    D  T LH A + GH R+ + LLD GA 
Sbjct: 307 -SPIHMA-AQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363

Query: 467 MN 468
            N
Sbjct: 364 PN 365



 Score =  124 bits (310), Expect = 5e-28
 Identities = 79/266 (29%), Positives = 132/266 (49%), Gaps = 7/266 (2%)

Query: 165 TENGLSLLHLCCICGGKKSHIRTLML-KGLRPSRLTRNGFTALHLAVYKDNAELITSLLH 223
           T+ G + LH+    G  K  +  L+L +   P+   +NG T LH+AV+ +N +++  LL 
Sbjct: 533 TKKGFTPLHVAAKYG--KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 224 SGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQV 283
            G       + G T LHIA     +E A  LLQ+G + N +     TPLH+AA  GH ++
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650

Query: 284 TRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFC 343
             LLL   A+ N+  + G  PLHL + +G + +A +L++ G   D  A     + PLH  
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD--ATTRMGYTPLHVA 708

Query: 344 SRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKEN 403
           S +G+  +VK+LLQ   +V  +     G +PLH A   G  ++   +++   + +    +
Sbjct: 709 SHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766

Query: 404 IFSETAFHSACTYGKSIDLVKFLLDQ 429
             +  A      Y    D++K + D+
Sbjct: 767 GTTPLAIAKRLGYISVTDVLKVVTDE 792



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 49/191 (25%), Positives = 80/191 (41%), Gaps = 48/191 (25%)

Query: 315 NIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTP 374
           N+ K L    +  D+N  +      LH  S+ GH  +V  LL  ++ ++       G+T 
Sbjct: 24  NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK--GNTA 81

Query: 375 LHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVINI 434
           LH+A   G+ EV +E++                        YG               N+
Sbjct: 82  LHIAALAGQDEVVRELVN-----------------------YGA--------------NV 104

Query: 435 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 494
           N Q + G T L+ A    H+ +V+FLL+NGA+ N+           +D  T L  A ++G
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT---------EDGFTPLAVALQQG 155

Query: 495 HDAIVTLLKHY 505
           H+ +V  L +Y
Sbjct: 156 HENVVAHLINY 166


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  157 bits (398), Expect = 3e-38
 Identities = 108/336 (32%), Positives = 166/336 (49%), Gaps = 46/336 (13%)

Query: 164 RTENGLSLLHLCCICGGKKSHIRT---LMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 220
           +T++ L+ LH    C  +  H+R    L+  G      T+NG + +H+A   D+ + +  
Sbjct: 268 KTKDELTPLH----CAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 221 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 280
           LL   A+I  +    LT LH+A   GH   A VLL  GA  N +    FTPLHIA    H
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383

Query: 281 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEG---------------- 324
            +V  LLLK GA ++   E G  PLH+AS  G L I K L++ G                
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443

Query: 325 ---------------SKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 369
                          +KA VNA+  +D  PLH  +R GH ++VK LL+++    P++   
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN--ANPNLATT 501

Query: 370 YGDTPLHLACYNGKFEVAKEIIQISGTES-LTKENIFSETAFHSACTYGKSIDLVKFLLD 428
            G TPLH+A   G  E    +++   +++ +TK+     T  H A  YGK + + + LL+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF---TPLHVAAKYGK-VRVAELLLE 557

Query: 429 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNG 464
           ++  + N  G++G T LH A +H ++ +V+ LL  G
Sbjct: 558 RDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592



 Score =  157 bits (397), Expect = 4e-38
 Identities = 120/373 (32%), Positives = 173/373 (46%), Gaps = 50/373 (13%)

Query: 165 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 224
           T + L+ LH+   CG  +   + L+ KG +P+    NGFT LH+A  K++  ++  LL +
Sbjct: 335 TLDHLTPLHVAAHCGHHRV-AKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393

Query: 225 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 284
           GA I  V   GLT LH+A+  GHL     LLQ GA+ N+ +    TPLH+AA  GH +V 
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453

Query: 285 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 344
           + LL+  A VN   +    PLH A+  G  N+ KLL+E  + A+ N      H PLH  +
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE--NNANPNLATTAGHTPLHIAA 511

Query: 345 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 404
           R GH + V  LL+   E     +   G TPLH+A   GK  VA+ +++     +   +N 
Sbjct: 512 REGHVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN- 568

Query: 405 FSETAFHSACTYGKSIDLVKFLL---------------------DQNVINI--------- 434
              T  H A  +  ++D+VK LL                      QN + +         
Sbjct: 569 -GLTPLHVA-VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626

Query: 435 --NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYE 492
             N +   G T LH A   GH  +V  LL   A+ NL         G K   T L    +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---------GNKSGLTPLHLVAQ 677

Query: 493 KGHDAIV-TLLKH 504
           +GH  +   L+KH
Sbjct: 678 EGHVPVADVLIKH 690



 Score =  154 bits (388), Expect = 5e-37
 Identities = 104/306 (33%), Positives = 156/306 (50%), Gaps = 9/306 (2%)

Query: 160 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 219
           ++N+  +NG++ LH+     G    +R L+ +G +    T++  T LH A    +  +  
Sbjct: 231 SVNFTPQNGITPLHIASR-RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289

Query: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279
            LL  GA IQ     GL+ +H+A    HL+   +LLQ+ A ++       TPLH+AA+ G
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349

Query: 280 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 339
           H +V ++LL  GA  N     G  PLH+A  K  + + +LL++ G  A ++A       P
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG--ASIDAVTESGLTP 407

Query: 340 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESL 399
           LH  S  GH  IVK LLQ      P+V N+  +TPLH+A   G  EVAK ++Q     + 
Sbjct: 408 LHVASFMGHLPIVKNLLQRG--ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465

Query: 400 TKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQF 459
             ++   +T  H A   G + ++VK LL+ N  N N     GHT LH A   GH+  V  
Sbjct: 466 KAKD--DQTPLHCAARIGHT-NMVKLLLENNA-NPNLATTAGHTPLHIAAREGHVETVLA 521

Query: 460 LLDNGA 465
           LL+  A
Sbjct: 522 LLEKEA 527



 Score =  141 bits (355), Expect = 3e-33
 Identities = 96/341 (28%), Positives = 160/341 (46%), Gaps = 38/341 (11%)

Query: 161 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKG-LRPSRLTRNGFTALHLAVYKDNAELIT 219
           +NY T+  + L  L        +    ++L+    P  L++ GFT LH+A + +N  +  
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223

Query: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279
            LL+ GA +      G+T LHIA+  G++    +LL  GA +  +     TPLH AA  G
Sbjct: 224 LLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNG 283

Query: 280 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 339
           H +++ +LL  GA +    + G  P+H+A+    L+  +LL++  ++ D    D+    P
Sbjct: 284 HVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--LTP 341

Query: 340 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY----------------------------- 370
           LH  +  GHH + K LL    +     +N +                             
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 371 --GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD 428
             G TPLH+A + G   + K ++Q   + +++  N+  ET  H A   G + ++ K+LL 
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPLHMAARAGHT-EVAKYLL- 457

Query: 429 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 469
           QN   +N + +D  T LH A   GH  +V+ LL+N A+ NL
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498



 Score =  140 bits (353), Expect = 6e-33
 Identities = 118/407 (28%), Positives = 182/407 (44%), Gaps = 84/407 (20%)

Query: 162 NYRTENGLSLLHLCCICGGKKSHIRT--LMLK-GLRPSRLTRNGFTALHLAVYKDNAELI 218
           N R  NG + LH+ C    KK+H+R   L+LK G     +T +G T LH+A +  +  ++
Sbjct: 365 NSRALNGFTPLHIAC----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 219 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 278
            +LL  GA          T LH+A  AGH E A  LLQ+ A VN +     TPLH AA  
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 279 GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHV 338
           GH  + +LLL+  A+ N++   G  PLH+A+ +G +     L+E+  +A       +   
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK--EASQACMTKKGFT 538

Query: 339 PLHFCSRFGHHDIVKYLLQSD----------------------LEV---------QPHVV 367
           PLH  +++G   + + LL+ D                      L++          PH  
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598

Query: 368 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL 427
              G TPLH+A    + EVA+ ++Q  G  S   E++   T  H A   G + ++V  LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGG--SANAESVQGVTPLHLAAQEGHA-EMVALLL 655

Query: 428 DQNV--------------------------------ININHQGRDGHTGLHSACYHGHIR 455
            +                                  + ++   R G+T LH A ++G+I+
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715

Query: 456 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
           LV+FLL + AD+N         +  K   + L  A ++GH  IVTLL
Sbjct: 716 LVKFLLQHQADVN---------AKTKLGYSPLHQAAQQGHTDIVTLL 753



 Score =  140 bits (352), Expect = 7e-33
 Identities = 98/317 (30%), Positives = 157/317 (49%), Gaps = 9/317 (2%)

Query: 157 SKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAE 216
           +K  +N + ++  + LH C    G  + ++ L+     P+  T  G T LH+A  + + E
Sbjct: 459 NKAKVNAKAKDDQTPLH-CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517

Query: 217 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 276
            + +LL   A    +   G T LH+A   G +  A++LL+  A+ N       TPLH+A 
Sbjct: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577

Query: 277 YYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 336
           ++ +  + +LLL  G   +     G  PLH+A+ +  + +A+ L++ G  A  NA+  + 
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQG 635

Query: 337 HVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGT 396
             PLH  ++ GH ++V  LL    +   ++ N  G TPLHL    G   VA  +I+    
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSK--QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 397 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 456
              T       T  H A  YG +I LVKFLL Q+  ++N + + G++ LH A   GH  +
Sbjct: 694 VDATTR--MGYTPLHVASHYG-NIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDI 749

Query: 457 VQFLLDNGADMNLVACD 473
           V  LL NGA  N V+ D
Sbjct: 750 VTLLLKNGASPNEVSSD 766



 Score =  136 bits (343), Expect = 8e-32
 Identities = 94/274 (34%), Positives = 141/274 (51%), Gaps = 12/274 (4%)

Query: 192 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAA 251
           G+  +   +NG   LHLA  + + +++  LLH    ++     G TALHIA +AG  E  
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 252 DVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAK 311
             L+ +GANVN Q    FTPL++AA   H +V + LL+ GA+ NV+ E G  PL +A  +
Sbjct: 95  RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154

Query: 312 GFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYG 371
           G  N+   L+  G+K  V          LH  +R         LLQ+D    P V++  G
Sbjct: 155 GHENVVAHLINYGTKGKVRLP------ALHIAARNDDTRTAAVLLQND--PNPDVLSKTG 206

Query: 372 DTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNV 431
            TPLH+A +     VA+ ++    + + T +N    T  H A   G  I +V+ LLD+  
Sbjct: 207 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASRRGNVI-MVRLLLDRGA 263

Query: 432 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGA 465
             I  + +D  T LH A  +GH+R+ + LLD+GA
Sbjct: 264 -QIETKTKDELTPLHCAARNGHVRISEILLDHGA 296



 Score =  136 bits (342), Expect = 1e-31
 Identities = 102/343 (29%), Positives = 170/343 (49%), Gaps = 40/343 (11%)

Query: 158 KVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAEL 217
           ++ L   T+ G + LH+  + G +   +R L+  G   +  ++ GFT L++A  +++ E+
Sbjct: 68  EIILETTTKKGNTALHIAALAG-QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126

Query: 218 ITSLLHSGAD---------------IQQ---------VGYG-----GLTALHIATIAGHL 248
           +  LL +GA+               +QQ         + YG      L ALHIA      
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186

Query: 249 EAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLA 308
             A VLLQ+  N ++     FTPLHIAA+Y +  V +LLL  GA VN + + G  PLH+A
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246

Query: 309 SAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVN 368
           S +G + + +LL++ G++ +   +D  +  PLH  +R GH  I + LL     +Q    N
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304

Query: 369 IYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFSETAFHSACTYGKSIDLVKFLL 427
             G +P+H+A      +  + ++Q     + +T +++   T  H A   G    + K LL
Sbjct: 305 --GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHH-RVAKVLL 358

Query: 428 DQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLV 470
           D+     N +  +G T LH AC   H+R+++ LL  GA ++ V
Sbjct: 359 DKGA-KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400



 Score =  129 bits (323), Expect = 2e-29
 Identities = 107/362 (29%), Positives = 164/362 (45%), Gaps = 55/362 (15%)

Query: 140 EKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIR---TLMLKGLRPS 196
           +K L  LRN          V++N   +NGL+ LHL      K+ H++    L+ K +   
Sbjct: 26  DKALDHLRN---------GVDINTCNQNGLNGLHL----ASKEGHVKMVVELLHKEIILE 72

Query: 197 RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQ 256
             T+ G TALH+A      E++  L++ GA++      G T L++A    HLE    LL+
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 257 HGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA------------------------ 292
           +GAN N+     FTPL +A   GHE V   L+ +G                         
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 293 -----DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 347
                + +V  + G  PLH+A+    LN+A+LL+  G  A VN        PLH  SR G
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG--ASVNFTPQNGITPLHIASRRG 250

Query: 348 HHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFS 406
           +  +V+ LL    +++    +    TPLH A  NG   +++ ++      ++ TK  +  
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-- 306

Query: 407 ETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGAD 466
            +  H A   G  +D V+ LL  +   I+    D  T LH A + GH R+ + LLD GA 
Sbjct: 307 -SPIHMA-AQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363

Query: 467 MN 468
            N
Sbjct: 364 PN 365



 Score =  124 bits (310), Expect = 5e-28
 Identities = 79/266 (29%), Positives = 132/266 (49%), Gaps = 7/266 (2%)

Query: 165 TENGLSLLHLCCICGGKKSHIRTLML-KGLRPSRLTRNGFTALHLAVYKDNAELITSLLH 223
           T+ G + LH+    G  K  +  L+L +   P+   +NG T LH+AV+ +N +++  LL 
Sbjct: 533 TKKGFTPLHVAAKYG--KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 224 SGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQV 283
            G       + G T LHIA     +E A  LLQ+G + N +     TPLH+AA  GH ++
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650

Query: 284 TRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFC 343
             LLL   A+ N+  + G  PLHL + +G + +A +L++ G   D  A     + PLH  
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD--ATTRMGYTPLHVA 708

Query: 344 SRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKEN 403
           S +G+  +VK+LLQ   +V  +     G +PLH A   G  ++   +++   + +    +
Sbjct: 709 SHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766

Query: 404 IFSETAFHSACTYGKSIDLVKFLLDQ 429
             +  A      Y    D++K + D+
Sbjct: 767 GTTPLAIAKRLGYISVTDVLKVVTDE 792



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 49/191 (25%), Positives = 80/191 (41%), Gaps = 48/191 (25%)

Query: 315 NIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTP 374
           N+ K L    +  D+N  +      LH  S+ GH  +V  LL  ++ ++       G+T 
Sbjct: 24  NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK--GNTA 81

Query: 375 LHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVINI 434
           LH+A   G+ EV +E++                        YG               N+
Sbjct: 82  LHIAALAGQDEVVRELVN-----------------------YGA--------------NV 104

Query: 435 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 494
           N Q + G T L+ A    H+ +V+FLL+NGA+ N+           +D  T L  A ++G
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT---------EDGFTPLAVALQQG 155

Query: 495 HDAIVTLLKHY 505
           H+ +V  L +Y
Sbjct: 156 HENVVAHLINY 166


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  157 bits (398), Expect = 3e-38
 Identities = 108/336 (32%), Positives = 166/336 (49%), Gaps = 46/336 (13%)

Query: 164 RTENGLSLLHLCCICGGKKSHIRT---LMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 220
           +T++ L+ LH    C  +  H+R    L+  G      T+NG + +H+A   D+ + +  
Sbjct: 268 KTKDELTPLH----CAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 221 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 280
           LL   A+I  +    LT LH+A   GH   A VLL  GA  N +    FTPLHIA    H
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383

Query: 281 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEG---------------- 324
            +V  LLLK GA ++   E G  PLH+AS  G L I K L++ G                
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443

Query: 325 ---------------SKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 369
                          +KA VNA+  +D  PLH  +R GH ++VK LL+++    P++   
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN--ANPNLATT 501

Query: 370 YGDTPLHLACYNGKFEVAKEIIQISGTES-LTKENIFSETAFHSACTYGKSIDLVKFLLD 428
            G TPLH+A   G  E    +++   +++ +TK+     T  H A  YGK + + + LL+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF---TPLHVAAKYGK-VRVAELLLE 557

Query: 429 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNG 464
           ++  + N  G++G T LH A +H ++ +V+ LL  G
Sbjct: 558 RDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592



 Score =  157 bits (397), Expect = 4e-38
 Identities = 120/373 (32%), Positives = 173/373 (46%), Gaps = 50/373 (13%)

Query: 165 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 224
           T + L+ LH+   CG  +   + L+ KG +P+    NGFT LH+A  K++  ++  LL +
Sbjct: 335 TLDHLTPLHVAAHCGHHRV-AKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393

Query: 225 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 284
           GA I  V   GLT LH+A+  GHL     LLQ GA+ N+ +    TPLH+AA  GH +V 
Sbjct: 394 GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVA 453

Query: 285 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 344
           + LL+  A VN   +    PLH A+  G  N+ KLL+E  + A+ N      H PLH  +
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE--NNANPNLATTAGHTPLHIAA 511

Query: 345 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 404
           R GH + V  LL+   E     +   G TPLH+A   GK  VA+ +++     +   +N 
Sbjct: 512 REGHVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN- 568

Query: 405 FSETAFHSACTYGKSIDLVKFLL---------------------DQNVINI--------- 434
              T  H A  +  ++D+VK LL                      QN + +         
Sbjct: 569 -GLTPLHVA-VHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626

Query: 435 --NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYE 492
             N +   G T LH A   GH  +V  LL   A+ NL         G K   T L    +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL---------GNKSGLTPLHLVAQ 677

Query: 493 KGHDAIV-TLLKH 504
           +GH  +   L+KH
Sbjct: 678 EGHVPVADVLIKH 690



 Score =  154 bits (388), Expect = 5e-37
 Identities = 104/306 (33%), Positives = 156/306 (50%), Gaps = 9/306 (2%)

Query: 160 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 219
           ++N+  +NG++ LH+     G    +R L+ +G +    T++  T LH A    +  +  
Sbjct: 231 SVNFTPQNGITPLHIASR-RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289

Query: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279
            LL  GA IQ     GL+ +H+A    HL+   +LLQ+ A ++       TPLH+AA+ G
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349

Query: 280 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 339
           H +V ++LL  GA  N     G  PLH+A  K  + + +LL++ G  A ++A       P
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG--ASIDAVTESGLTP 407

Query: 340 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESL 399
           LH  S  GH  IVK LLQ      P+V N+  +TPLH+A   G  EVAK ++Q     + 
Sbjct: 408 LHVASFMGHLPIVKNLLQRG--ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465

Query: 400 TKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQF 459
             ++   +T  H A   G + ++VK LL+ N  N N     GHT LH A   GH+  V  
Sbjct: 466 KAKD--DQTPLHCAARIGHT-NMVKLLLENNA-NPNLATTAGHTPLHIAAREGHVETVLA 521

Query: 460 LLDNGA 465
           LL+  A
Sbjct: 522 LLEKEA 527



 Score =  141 bits (355), Expect = 3e-33
 Identities = 96/341 (28%), Positives = 160/341 (46%), Gaps = 38/341 (11%)

Query: 161 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKG-LRPSRLTRNGFTALHLAVYKDNAELIT 219
           +NY T+  + L  L        +    ++L+    P  L++ GFT LH+A + +N  +  
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223

Query: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279
            LL+ GA +      G+T LHIA+  G++    +LL  GA +  +     TPLH AA  G
Sbjct: 224 LLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNG 283

Query: 280 HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 339
           H +++ +LL  GA +    + G  P+H+A+    L+  +LL++  ++ D    D+    P
Sbjct: 284 HVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH--LTP 341

Query: 340 LHFCSRFGHHDIVKYLLQSDLEVQPHVVNIY----------------------------- 370
           LH  +  GHH + K LL    +     +N +                             
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401

Query: 371 --GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLD 428
             G TPLH+A + G   + K ++Q   + +++  N+  ET  H A   G + ++ K+LL 
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPLHMAARAGHT-EVAKYLL- 457

Query: 429 QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 469
           QN   +N + +D  T LH A   GH  +V+ LL+N A+ NL
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498



 Score =  140 bits (353), Expect = 6e-33
 Identities = 118/407 (28%), Positives = 182/407 (44%), Gaps = 84/407 (20%)

Query: 162 NYRTENGLSLLHLCCICGGKKSHIRT--LMLK-GLRPSRLTRNGFTALHLAVYKDNAELI 218
           N R  NG + LH+ C    KK+H+R   L+LK G     +T +G T LH+A +  +  ++
Sbjct: 365 NSRALNGFTPLHIAC----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 219 TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY 278
            +LL  GA          T LH+A  AGH E A  LLQ+ A VN +     TPLH AA  
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 279 GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHV 338
           GH  + +LLL+  A+ N++   G  PLH+A+ +G +     L+E+  +A       +   
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK--EASQACMTKKGFT 538

Query: 339 PLHFCSRFGHHDIVKYLLQSD----------------------LEV---------QPHVV 367
           PLH  +++G   + + LL+ D                      L++          PH  
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598

Query: 368 NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLL 427
              G TPLH+A    + EVA+ ++Q  G  S   E++   T  H A   G + ++V  LL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGG--SANAESVQGVTPLHLAAQEGHA-EMVALLL 655

Query: 428 DQNV--------------------------------ININHQGRDGHTGLHSACYHGHIR 455
            +                                  + ++   R G+T LH A ++G+I+
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715

Query: 456 LVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
           LV+FLL + AD+N         +  K   + L  A ++GH  IVTLL
Sbjct: 716 LVKFLLQHQADVN---------AKTKLGYSPLHQAAQQGHTDIVTLL 753



 Score =  140 bits (352), Expect = 7e-33
 Identities = 98/317 (30%), Positives = 157/317 (49%), Gaps = 9/317 (2%)

Query: 157 SKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAE 216
           +K  +N + ++  + LH C    G  + ++ L+     P+  T  G T LH+A  + + E
Sbjct: 459 NKAKVNAKAKDDQTPLH-CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517

Query: 217 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAA 276
            + +LL   A    +   G T LH+A   G +  A++LL+  A+ N       TPLH+A 
Sbjct: 518 TVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577

Query: 277 YYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNED 336
           ++ +  + +LLL  G   +     G  PLH+A+ +  + +A+ L++ G  A  NA+  + 
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQG 635

Query: 337 HVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGT 396
             PLH  ++ GH ++V  LL    +   ++ N  G TPLHL    G   VA  +I+    
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSK--QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 397 ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL 456
              T       T  H A  YG +I LVKFLL Q+  ++N + + G++ LH A   GH  +
Sbjct: 694 VDATTR--MGYTPLHVASHYG-NIKLVKFLL-QHQADVNAKTKLGYSPLHQAAQQGHTDI 749

Query: 457 VQFLLDNGADMNLVACD 473
           V  LL NGA  N V+ D
Sbjct: 750 VTLLLKNGASPNEVSSD 766



 Score =  136 bits (343), Expect = 8e-32
 Identities = 94/274 (34%), Positives = 141/274 (51%), Gaps = 12/274 (4%)

Query: 192 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAA 251
           G+  +   +NG   LHLA  + + +++  LLH    ++     G TALHIA +AG  E  
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 252 DVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAK 311
             L+ +GANVN Q    FTPL++AA   H +V + LL+ GA+ NV+ E G  PL +A  +
Sbjct: 95  RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ 154

Query: 312 GFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYG 371
           G  N+   L+  G+K  V          LH  +R         LLQ+D    P V++  G
Sbjct: 155 GHENVVAHLINYGTKGKVRLP------ALHIAARNDDTRTAAVLLQND--PNPDVLSKTG 206

Query: 372 DTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNV 431
            TPLH+A +     VA+ ++    + + T +N    T  H A   G  I +V+ LLD+  
Sbjct: 207 FTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASRRGNVI-MVRLLLDRGA 263

Query: 432 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGA 465
             I  + +D  T LH A  +GH+R+ + LLD+GA
Sbjct: 264 -QIETKTKDELTPLHCAARNGHVRISEILLDHGA 296



 Score =  136 bits (342), Expect = 1e-31
 Identities = 102/343 (29%), Positives = 170/343 (49%), Gaps = 40/343 (11%)

Query: 158 KVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAEL 217
           ++ L   T+ G + LH+  + G +   +R L+  G   +  ++ GFT L++A  +++ E+
Sbjct: 68  EIILETTTKKGNTALHIAALAG-QDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126

Query: 218 ITSLLHSGAD---------------IQQ---------VGYG-----GLTALHIATIAGHL 248
           +  LL +GA+               +QQ         + YG      L ALHIA      
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186

Query: 249 EAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLA 308
             A VLLQ+  N ++     FTPLHIAA+Y +  V +LLL  GA VN + + G  PLH+A
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246

Query: 309 SAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVN 368
           S +G + + +LL++ G++ +   +D  +  PLH  +R GH  I + LL     +Q    N
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304

Query: 369 IYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFSETAFHSACTYGKSIDLVKFLL 427
             G +P+H+A      +  + ++Q     + +T +++   T  H A   G    + K LL
Sbjct: 305 --GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHH-RVAKVLL 358

Query: 428 DQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLV 470
           D+     N +  +G T LH AC   H+R+++ LL  GA ++ V
Sbjct: 359 DKGA-KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400



 Score =  129 bits (323), Expect = 2e-29
 Identities = 107/362 (29%), Positives = 164/362 (45%), Gaps = 55/362 (15%)

Query: 140 EKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIR---TLMLKGLRPS 196
           +K L  LRN          V++N   +NGL+ LHL      K+ H++    L+ K +   
Sbjct: 26  DKALDHLRN---------GVDINTCNQNGLNGLHL----ASKEGHVKMVVELLHKEIILE 72

Query: 197 RLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQ 256
             T+ G TALH+A      E++  L++ GA++      G T L++A    HLE    LL+
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 257 HGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA------------------------ 292
           +GAN N+     FTPL +A   GHE V   L+ +G                         
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 293 -----DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFG 347
                + +V  + G  PLH+A+    LN+A+LL+  G  A VN        PLH  SR G
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG--ASVNFTPQNGITPLHIASRRG 250

Query: 348 HHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFS 406
           +  +V+ LL    +++    +    TPLH A  NG   +++ ++      ++ TK  +  
Sbjct: 251 NVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-- 306

Query: 407 ETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGAD 466
            +  H A   G  +D V+ LL  +   I+    D  T LH A + GH R+ + LLD GA 
Sbjct: 307 -SPIHMA-AQGDHLDCVRLLLQYDA-EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363

Query: 467 MN 468
            N
Sbjct: 364 PN 365



 Score =  124 bits (310), Expect = 5e-28
 Identities = 79/266 (29%), Positives = 132/266 (49%), Gaps = 7/266 (2%)

Query: 165 TENGLSLLHLCCICGGKKSHIRTLML-KGLRPSRLTRNGFTALHLAVYKDNAELITSLLH 223
           T+ G + LH+    G  K  +  L+L +   P+   +NG T LH+AV+ +N +++  LL 
Sbjct: 533 TKKGFTPLHVAAKYG--KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 224 SGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQV 283
            G       + G T LHIA     +E A  LLQ+G + N +     TPLH+AA  GH ++
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650

Query: 284 TRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFC 343
             LLL   A+ N+  + G  PLHL + +G + +A +L++ G   D  A     + PLH  
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD--ATTRMGYTPLHVA 708

Query: 344 SRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKEN 403
           S +G+  +VK+LLQ   +V  +     G +PLH A   G  ++   +++   + +    +
Sbjct: 709 SHYGNIKLVKFLLQHQADV--NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 766

Query: 404 IFSETAFHSACTYGKSIDLVKFLLDQ 429
             +  A      Y    D++K + D+
Sbjct: 767 GTTPLAIAKRLGYISVTDVLKVVTDE 792



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 49/191 (25%), Positives = 80/191 (41%), Gaps = 48/191 (25%)

Query: 315 NIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTP 374
           N+ K L    +  D+N  +      LH  S+ GH  +V  LL  ++ ++       G+T 
Sbjct: 24  NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK--GNTA 81

Query: 375 LHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVINI 434
           LH+A   G+ EV +E++                        YG               N+
Sbjct: 82  LHIAALAGQDEVVRELVN-----------------------YGA--------------NV 104

Query: 435 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 494
           N Q + G T L+ A    H+ +V+FLL+NGA+ N+           +D  T L  A ++G
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT---------EDGFTPLAVALQQG 155

Query: 495 HDAIVTLLKHY 505
           H+ +V  L +Y
Sbjct: 156 HENVVAHLINY 166


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  157 bits (396), Expect = 6e-38
 Identities = 115/376 (30%), Positives = 172/376 (45%), Gaps = 47/376 (12%)

Query: 161 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 220
           ++ +T +GL+ LH C    G    +  L+ +G      T+NG + LH+A   D+ E +  
Sbjct: 271 IDAKTRDGLTPLH-CAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 329

Query: 221 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 280
           LL   A +  V    LTALH+A   GH     +LL   AN N +    FTPLHIA     
Sbjct: 330 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 389

Query: 281 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD------------ 328
            +V  LL+K+GA +    E G  P+H+A+  G LNI  LL++ G+  D            
Sbjct: 390 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 449

Query: 329 -------------------VNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 369
                              V+A+  E+  PLH  SR G  +IV+ LLQ      P     
Sbjct: 450 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH--MAHPDAATT 507

Query: 370 YGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQ 429
            G TPLH++   G+ +VA  +++     SL  +  F  T  H A  YG S+D+ K LL +
Sbjct: 508 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF--TPLHVAAKYG-SLDVAKLLLQR 564

Query: 430 NVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMW 489
                +  G++G T LH A ++ + ++   LL+ GA  +  A         K+  T L  
Sbjct: 565 RAA-ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA---------KNGYTPLHI 614

Query: 490 AYEKGHDAIVTLLKHY 505
           A +K    I + L +Y
Sbjct: 615 AAKKNQMQIASTLLNY 630



 Score =  148 bits (374), Expect = 2e-35
 Identities = 104/324 (32%), Positives = 158/324 (48%), Gaps = 17/324 (5%)

Query: 180 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 239
           GK   ++ L+     P   T NG+T LH++  +   ++ + LL +GA        G T L
Sbjct: 487 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 546

Query: 240 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGE 299
           H+A   G L+ A +LLQ  A  +       TPLH+AA+Y +++V  LLL+ GA  + + +
Sbjct: 547 HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK 606

Query: 300 VGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD 359
            G  PLH+A+ K  + IA  L+  G  A+ N    +   PLH  S+ GH D+V  LL   
Sbjct: 607 NGYTPLHIAAKKNQMQIASTLLNYG--AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 664

Query: 360 LEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKS 419
             +  H+    G T LHLA    K  VA +I+   G +      +   T    AC YG +
Sbjct: 665 ANI--HMSTKSGLTSLHLAAQEDKVNVA-DILTKHGADQDAHTKL-GYTPLIVACHYG-N 719

Query: 420 IDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSG 479
           + +V FLL Q   N+N + ++G+T LH A   GH  ++  LL +GA  N    + +    
Sbjct: 720 VKMVNFLLKQGA-NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGN---- 774

Query: 480 EKDEQTCLMWAYEKGHDAIVTLLK 503
                T L  A   G+ ++V  LK
Sbjct: 775 -----TALAIAKRLGYISVVDTLK 793



 Score =  139 bits (349), Expect = 2e-32
 Identities = 113/420 (26%), Positives = 188/420 (44%), Gaps = 89/420 (21%)

Query: 158 KVNLNYRTENGLSLLHLCCICGGKKSHIRTLML---KGLRPSRLTRNGFTALHLAVYKDN 214
           + N N R  NG + LH+ C    KK+ I+ + L    G     +T +G T +H+A +  +
Sbjct: 367 RANPNARALNGFTPLHIAC----KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGH 422

Query: 215 AELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHI 274
             ++  LL +GA        G TALH+A  AG +E    LL++GA V+ +     TPLHI
Sbjct: 423 LNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 482

Query: 275 AAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDN 334
           A+  G  ++ +LLL+  A  + +   G  PLH+++ +G +++A +L+E G+   +  +  
Sbjct: 483 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK-- 540

Query: 335 EDHVPLHFCSRFGHHDIVKYLLQS-------------------------------DLEVQ 363
           +   PLH  +++G  D+ K LLQ                                +    
Sbjct: 541 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 600

Query: 364 PHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFSETAFHSACTYGKSIDL 422
           PH     G TPLH+A    + ++A  ++     T  +TK+ +   T  H A   G + D+
Sbjct: 601 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV---TPLHLASQEGHT-DM 656

Query: 423 VKFLLDQNVININHQGRDGHTGLH---------------------------------SAC 449
           V  LLD+   NI+   + G T LH                                  AC
Sbjct: 657 VTLLLDKGA-NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVAC 715

Query: 450 YHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIV-TLLKHYKRP 508
           ++G++++V FLL  GA++N         +  K+  T L  A ++GH  I+  LL+H  +P
Sbjct: 716 HYGNVKMVNFLLKQGANVN---------AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 766



 Score =  137 bits (344), Expect = 6e-32
 Identities = 101/324 (31%), Positives = 159/324 (49%), Gaps = 19/324 (5%)

Query: 196 SRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLL 255
           +R T +GFT LH+A +  N  + T LL+ GA +      G+T LH+A+  G+     +LL
Sbjct: 206 NRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLL 265

Query: 256 QHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLN 315
             G  ++ +     TPLH AA  GH+QV  LLL+ GA +    + G  PLH+A+    + 
Sbjct: 266 DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE 325

Query: 316 IAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL 375
             K L++   KA V+    +    LH  +  GH+ + K LL  D    P+   + G TPL
Sbjct: 326 CVKHLLQH--KAPVDDVTLDYLTALHVAAHCGHYRVTKLLL--DKRANPNARALNGFTPL 381

Query: 376 HLACYNGKFEVAKEIIQISGT-ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVINI 434
           H+AC   + +V + +++   + +++T+  +   T  H A   G  +++V  LL QN  + 
Sbjct: 382 HIACKKNRIKVMELLVKYGASIQAITESGL---TPIHVAAFMGH-LNIVLLLL-QNGASP 436

Query: 435 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 494
           +     G T LH A   G + +V+ LL NGA ++  A         ++EQT L  A   G
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA---------REEQTPLHIASRLG 487

Query: 495 HDAIVTLLKHYKRPQDELPCNEYS 518
              IV LL  +    D    N Y+
Sbjct: 488 KTEIVQLLLQHMAHPDAATTNGYT 511



 Score =  132 bits (332), Expect = 2e-30
 Identities = 104/327 (31%), Positives = 156/327 (47%), Gaps = 25/327 (7%)

Query: 192 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAA 251
           G+  +   +NG  ALHLA  + +  L+  LL  G+ +      G TALHIA++AG  E  
Sbjct: 33  GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVV 92

Query: 252 DVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAK 311
            VL++ GAN+N Q    FTPL++AA   H  V + LL+ GA+ + + E G  PL +A  +
Sbjct: 93  KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQ 152

Query: 312 GFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD--LEVQPHVV-- 367
           G      +L+E  +K  V          LH  +R         LLQ+D   +VQ  ++  
Sbjct: 153 GHNQAVAILLENDTKGKVRLP------ALHIAARKDDTKSAALLLQNDHNADVQSKMMVN 206

Query: 368 --NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKF 425
                G TPLH+A + G   VA  ++        T  N    T  H A   G + ++VK 
Sbjct: 207 RTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN--GITPLHVASKRGNT-NMVKL 263

Query: 426 LLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQT 485
           LLD+    I+ + RDG T LH A   GH ++V+ LL+ GA +          +  K+  +
Sbjct: 264 LLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL---------LARTKNGLS 313

Query: 486 CLMWAYEKGHDAIVTLLKHYKRPQDEL 512
            L  A +  H   V  L  +K P D++
Sbjct: 314 PLHMAAQGDHVECVKHLLQHKAPVDDV 340



 Score =  123 bits (309), Expect = 7e-28
 Identities = 102/350 (29%), Positives = 160/350 (45%), Gaps = 52/350 (14%)

Query: 159 VNLNYRTENGLSLLHLCCICGGKKSHI---RTLMLKGLRPSRLTRNGFTALHLAVYKDNA 215
           +++N   +NGL+ LHL      K+ H+   + L+ +G      T+ G TALH+A     A
Sbjct: 34  IDINTCNQNGLNALHLAA----KEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 89

Query: 216 ELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIA 275
           E++  L+  GA+I      G T L++A    H++    LL++GAN +      FTPL +A
Sbjct: 90  EVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 149

Query: 276 AYYGHEQVTRLLLK-------------------------------FGAD------VNVSG 298
              GH Q   +LL+                                 AD      VN + 
Sbjct: 150 LQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTT 209

Query: 299 EVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQS 358
           E G  PLH+A+  G +N+A LL+  G+  D  A++     PLH  S+ G+ ++VK LL  
Sbjct: 210 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG--ITPLHVASKRGNTNMVKLLLDR 267

Query: 359 DLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGK 418
             ++     +  G TPLH A  +G  +V + +++         +N  S    H A   G 
Sbjct: 268 GGQIDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS--PLHMA-AQGD 322

Query: 419 SIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 468
            ++ VK LL Q+   ++    D  T LH A + GH R+ + LLD  A+ N
Sbjct: 323 HVECVKHLL-QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 371



 Score =  115 bits (289), Expect = 1e-25
 Identities = 78/265 (29%), Positives = 123/265 (46%), Gaps = 5/265 (1%)

Query: 165 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 224
           T+ G + LH+    G      + L+ +        +NG T LH+A + DN ++   LL  
Sbjct: 539 TKKGFTPLHVAAKYGSLDV-AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 597

Query: 225 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 284
           GA        G T LHIA     ++ A  LL +GA  NI      TPLH+A+  GH  + 
Sbjct: 598 GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMV 657

Query: 285 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 344
            LLL  GA++++S + G   LHLA+ +  +N+A +L + G  AD +A     + PL    
Sbjct: 658 TLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG--ADQDAHTKLGYTPLIVAC 715

Query: 345 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 404
            +G+  +V +LL+    V     N  G TPLH A   G   +   ++Q     + T  N 
Sbjct: 716 HYGNVKMVNFLLKQGANVNAKTKN--GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 773

Query: 405 FSETAFHSACTYGKSIDLVKFLLDQ 429
            +  A      Y   +D +K + ++
Sbjct: 774 NTALAIAKRLGYISVVDTLKVVTEE 798



 Score =  107 bits (268), Expect = 4e-23
 Identities = 72/235 (30%), Positives = 119/235 (50%), Gaps = 15/235 (6%)

Query: 166 ENGLSLLHLCCICGGKKSHIR---TLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL 222
           +NG + LH+      KK+ ++   TL+  G   + +T+ G T LHLA  + + +++T LL
Sbjct: 606 KNGYTPLHIAA----KKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 661

Query: 223 HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQ 282
             GA+I      GLT+LH+A     +  AD+L +HGA+ +    + +TPL +A +YG+ +
Sbjct: 662 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 721

Query: 283 VTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 342
           +   LLK GA+VN   + G  PLH A+ +G  +I  +L++ G+K   NA     +  L  
Sbjct: 722 MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP--NATTANGNTALAI 779

Query: 343 CSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTE 397
             R G+  +V  L     EV      I     L++       E   E++ +S  E
Sbjct: 780 AKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVP------ETMTEVLDVSDEE 828



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 82/296 (27%), Positives = 134/296 (45%), Gaps = 50/296 (16%)

Query: 242 ATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVG 301
           A  AG+L+     L+ G ++N  +      LH+AA  GH  + + LL  G+ V+ + + G
Sbjct: 17  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76

Query: 302 DRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLE 361
           +  LH+AS  G   + K+L++EG  A++NAQ      PL+  ++  H D+VKYLL++   
Sbjct: 77  NTALHIASLAGQAEVVKVLVKEG--ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 134

Query: 362 VQPHVVNIYGDTPLHLACYNG-------------KFEVAKEIIQISGTESLTKE------ 402
                 +  G TPL +A   G             K +V    + I+  +  TK       
Sbjct: 135 QSTATED--GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 192

Query: 403 -------------NIFSETAF---HSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLH 446
                        N  +E+ F   H A  YG ++++   LL++    ++   R+G T LH
Sbjct: 193 NDHNADVQSKMMVNRTTESGFTPLHIAAHYG-NVNVATLLLNRGAA-VDFTARNGITPLH 250

Query: 447 SACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
            A   G+  +V+ LLD G  ++         +  +D  T L  A   GHD +V LL
Sbjct: 251 VASKRGNTNMVKLLLDRGGQID---------AKTRDGLTPLHCAARSGHDQVVELL 297


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  157 bits (396), Expect = 6e-38
 Identities = 115/376 (30%), Positives = 172/376 (45%), Gaps = 47/376 (12%)

Query: 161 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 220
           ++ +T +GL+ LH C    G    +  L+ +G      T+NG + LH+A   D+ E +  
Sbjct: 292 IDAKTRDGLTPLH-CAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350

Query: 221 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 280
           LL   A +  V    LTALH+A   GH     +LL   AN N +    FTPLHIA     
Sbjct: 351 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 410

Query: 281 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD------------ 328
            +V  LL+K+GA +    E G  P+H+A+  G LNI  LL++ G+  D            
Sbjct: 411 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 470

Query: 329 -------------------VNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 369
                              V+A+  E+  PLH  SR G  +IV+ LLQ      P     
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH--MAHPDAATT 528

Query: 370 YGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQ 429
            G TPLH++   G+ +VA  +++     SL  +  F  T  H A  YG S+D+ K LL +
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF--TPLHVAAKYG-SLDVAKLLLQR 585

Query: 430 NVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMW 489
                +  G++G T LH A ++ + ++   LL+ GA  +  A         K+  T L  
Sbjct: 586 RAA-ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA---------KNGYTPLHI 635

Query: 490 AYEKGHDAIVTLLKHY 505
           A +K    I + L +Y
Sbjct: 636 AAKKNQMQIASTLLNY 651



 Score =  148 bits (374), Expect = 2e-35
 Identities = 104/324 (32%), Positives = 158/324 (48%), Gaps = 17/324 (5%)

Query: 180 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 239
           GK   ++ L+     P   T NG+T LH++  +   ++ + LL +GA        G T L
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 567

Query: 240 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGE 299
           H+A   G L+ A +LLQ  A  +       TPLH+AA+Y +++V  LLL+ GA  + + +
Sbjct: 568 HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK 627

Query: 300 VGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD 359
            G  PLH+A+ K  + IA  L+  G  A+ N    +   PLH  S+ GH D+V  LL   
Sbjct: 628 NGYTPLHIAAKKNQMQIASTLLNYG--AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 685

Query: 360 LEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKS 419
             +  H+    G T LHLA    K  VA +I+   G +      +   T    AC YG +
Sbjct: 686 ANI--HMSTKSGLTSLHLAAQEDKVNVA-DILTKHGADQDAHTKL-GYTPLIVACHYG-N 740

Query: 420 IDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSG 479
           + +V FLL Q   N+N + ++G+T LH A   GH  ++  LL +GA  N    + +    
Sbjct: 741 VKMVNFLLKQGA-NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGN---- 795

Query: 480 EKDEQTCLMWAYEKGHDAIVTLLK 503
                T L  A   G+ ++V  LK
Sbjct: 796 -----TALAIAKRLGYISVVDTLK 814



 Score =  139 bits (349), Expect = 2e-32
 Identities = 113/420 (26%), Positives = 188/420 (44%), Gaps = 89/420 (21%)

Query: 158 KVNLNYRTENGLSLLHLCCICGGKKSHIRTLML---KGLRPSRLTRNGFTALHLAVYKDN 214
           + N N R  NG + LH+ C    KK+ I+ + L    G     +T +G T +H+A +  +
Sbjct: 388 RANPNARALNGFTPLHIAC----KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGH 443

Query: 215 AELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHI 274
             ++  LL +GA        G TALH+A  AG +E    LL++GA V+ +     TPLHI
Sbjct: 444 LNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503

Query: 275 AAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDN 334
           A+  G  ++ +LLL+  A  + +   G  PLH+++ +G +++A +L+E G+   +  +  
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK-- 561

Query: 335 EDHVPLHFCSRFGHHDIVKYLLQS-------------------------------DLEVQ 363
           +   PLH  +++G  D+ K LLQ                                +    
Sbjct: 562 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 621

Query: 364 PHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFSETAFHSACTYGKSIDL 422
           PH     G TPLH+A    + ++A  ++     T  +TK+ +   T  H A   G + D+
Sbjct: 622 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV---TPLHLASQEGHT-DM 677

Query: 423 VKFLLDQNVININHQGRDGHTGLH---------------------------------SAC 449
           V  LLD+   NI+   + G T LH                                  AC
Sbjct: 678 VTLLLDKGA-NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVAC 736

Query: 450 YHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIV-TLLKHYKRP 508
           ++G++++V FLL  GA++N         +  K+  T L  A ++GH  I+  LL+H  +P
Sbjct: 737 HYGNVKMVNFLLKQGANVN---------AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787



 Score =  137 bits (344), Expect = 6e-32
 Identities = 101/324 (31%), Positives = 159/324 (49%), Gaps = 19/324 (5%)

Query: 196 SRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLL 255
           +R T +GFT LH+A +  N  + T LL+ GA +      G+T LH+A+  G+     +LL
Sbjct: 227 NRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLL 286

Query: 256 QHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLN 315
             G  ++ +     TPLH AA  GH+QV  LLL+ GA +    + G  PLH+A+    + 
Sbjct: 287 DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE 346

Query: 316 IAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL 375
             K L++   KA V+    +    LH  +  GH+ + K LL  D    P+   + G TPL
Sbjct: 347 CVKHLLQH--KAPVDDVTLDYLTALHVAAHCGHYRVTKLLL--DKRANPNARALNGFTPL 402

Query: 376 HLACYNGKFEVAKEIIQISGT-ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVINI 434
           H+AC   + +V + +++   + +++T+  +   T  H A   G  +++V  LL QN  + 
Sbjct: 403 HIACKKNRIKVMELLVKYGASIQAITESGL---TPIHVAAFMGH-LNIVLLLL-QNGASP 457

Query: 435 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 494
           +     G T LH A   G + +V+ LL NGA ++  A         ++EQT L  A   G
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA---------REEQTPLHIASRLG 508

Query: 495 HDAIVTLLKHYKRPQDELPCNEYS 518
              IV LL  +    D    N Y+
Sbjct: 509 KTEIVQLLLQHMAHPDAATTNGYT 532



 Score =  132 bits (332), Expect = 2e-30
 Identities = 104/327 (31%), Positives = 156/327 (47%), Gaps = 25/327 (7%)

Query: 192 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAA 251
           G+  +   +NG  ALHLA  + +  L+  LL  G+ +      G TALHIA++AG  E  
Sbjct: 54  GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVV 113

Query: 252 DVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAK 311
            VL++ GAN+N Q    FTPL++AA   H  V + LL+ GA+ + + E G  PL +A  +
Sbjct: 114 KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQ 173

Query: 312 GFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD--LEVQPHVV-- 367
           G      +L+E  +K  V          LH  +R         LLQ+D   +VQ  ++  
Sbjct: 174 GHNQAVAILLENDTKGKVRLP------ALHIAARKDDTKSAALLLQNDHNADVQSKMMVN 227

Query: 368 --NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKF 425
                G TPLH+A + G   VA  ++        T  N    T  H A   G + ++VK 
Sbjct: 228 RTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN--GITPLHVASKRGNT-NMVKL 284

Query: 426 LLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQT 485
           LLD+    I+ + RDG T LH A   GH ++V+ LL+ GA +          +  K+  +
Sbjct: 285 LLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL---------LARTKNGLS 334

Query: 486 CLMWAYEKGHDAIVTLLKHYKRPQDEL 512
            L  A +  H   V  L  +K P D++
Sbjct: 335 PLHMAAQGDHVECVKHLLQHKAPVDDV 361



 Score =  123 bits (309), Expect = 7e-28
 Identities = 102/350 (29%), Positives = 160/350 (45%), Gaps = 52/350 (14%)

Query: 159 VNLNYRTENGLSLLHLCCICGGKKSHI---RTLMLKGLRPSRLTRNGFTALHLAVYKDNA 215
           +++N   +NGL+ LHL      K+ H+   + L+ +G      T+ G TALH+A     A
Sbjct: 55  IDINTCNQNGLNALHLAA----KEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 110

Query: 216 ELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIA 275
           E++  L+  GA+I      G T L++A    H++    LL++GAN +      FTPL +A
Sbjct: 111 EVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170

Query: 276 AYYGHEQVTRLLLK-------------------------------FGAD------VNVSG 298
              GH Q   +LL+                                 AD      VN + 
Sbjct: 171 LQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTT 230

Query: 299 EVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQS 358
           E G  PLH+A+  G +N+A LL+  G+  D  A++     PLH  S+ G+ ++VK LL  
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG--ITPLHVASKRGNTNMVKLLLDR 288

Query: 359 DLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGK 418
             ++     +  G TPLH A  +G  +V + +++         +N  S    H A   G 
Sbjct: 289 GGQIDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS--PLHMA-AQGD 343

Query: 419 SIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 468
            ++ VK LL Q+   ++    D  T LH A + GH R+ + LLD  A+ N
Sbjct: 344 HVECVKHLL-QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 392



 Score =  115 bits (289), Expect = 1e-25
 Identities = 78/265 (29%), Positives = 123/265 (46%), Gaps = 5/265 (1%)

Query: 165 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 224
           T+ G + LH+    G      + L+ +        +NG T LH+A + DN ++   LL  
Sbjct: 560 TKKGFTPLHVAAKYGSLDV-AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 618

Query: 225 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 284
           GA        G T LHIA     ++ A  LL +GA  NI      TPLH+A+  GH  + 
Sbjct: 619 GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMV 678

Query: 285 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 344
            LLL  GA++++S + G   LHLA+ +  +N+A +L + G  AD +A     + PL    
Sbjct: 679 TLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG--ADQDAHTKLGYTPLIVAC 736

Query: 345 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 404
            +G+  +V +LL+    V     N  G TPLH A   G   +   ++Q     + T  N 
Sbjct: 737 HYGNVKMVNFLLKQGANVNAKTKN--GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794

Query: 405 FSETAFHSACTYGKSIDLVKFLLDQ 429
            +  A      Y   +D +K + ++
Sbjct: 795 NTALAIAKRLGYISVVDTLKVVTEE 819



 Score =  107 bits (268), Expect = 4e-23
 Identities = 72/235 (30%), Positives = 119/235 (50%), Gaps = 15/235 (6%)

Query: 166 ENGLSLLHLCCICGGKKSHIR---TLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL 222
           +NG + LH+      KK+ ++   TL+  G   + +T+ G T LHLA  + + +++T LL
Sbjct: 627 KNGYTPLHIAA----KKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682

Query: 223 HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQ 282
             GA+I      GLT+LH+A     +  AD+L +HGA+ +    + +TPL +A +YG+ +
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 742

Query: 283 VTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 342
           +   LLK GA+VN   + G  PLH A+ +G  +I  +L++ G+K   NA     +  L  
Sbjct: 743 MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP--NATTANGNTALAI 800

Query: 343 CSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTE 397
             R G+  +V  L     EV      I     L++       E   E++ +S  E
Sbjct: 801 AKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVP------ETMTEVLDVSDEE 849



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 82/296 (27%), Positives = 134/296 (45%), Gaps = 50/296 (16%)

Query: 242 ATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVG 301
           A  AG+L+     L+ G ++N  +      LH+AA  GH  + + LL  G+ V+ + + G
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 302 DRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLE 361
           +  LH+AS  G   + K+L++EG  A++NAQ      PL+  ++  H D+VKYLL++   
Sbjct: 98  NTALHIASLAGQAEVVKVLVKEG--ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155

Query: 362 VQPHVVNIYGDTPLHLACYNG-------------KFEVAKEIIQISGTESLTKE------ 402
                 +  G TPL +A   G             K +V    + I+  +  TK       
Sbjct: 156 QSTATED--GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213

Query: 403 -------------NIFSETAF---HSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLH 446
                        N  +E+ F   H A  YG ++++   LL++    ++   R+G T LH
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYG-NVNVATLLLNRGAA-VDFTARNGITPLH 271

Query: 447 SACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
            A   G+  +V+ LLD G  ++         +  +D  T L  A   GHD +V LL
Sbjct: 272 VASKRGNTNMVKLLLDRGGQID---------AKTRDGLTPLHCAARSGHDQVVELL 318


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  157 bits (396), Expect = 6e-38
 Identities = 115/376 (30%), Positives = 172/376 (45%), Gaps = 47/376 (12%)

Query: 161 LNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITS 220
           ++ +T +GL+ LH C    G    +  L+ +G      T+NG + LH+A   D+ E +  
Sbjct: 292 IDAKTRDGLTPLH-CAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350

Query: 221 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGH 280
           LL   A +  V    LTALH+A   GH     +LL   AN N +    FTPLHIA     
Sbjct: 351 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 410

Query: 281 EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD------------ 328
            +V  LL+K+GA +    E G  P+H+A+  G LNI  LL++ G+  D            
Sbjct: 411 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHM 470

Query: 329 -------------------VNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 369
                              V+A+  E+  PLH  SR G  +IV+ LLQ      P     
Sbjct: 471 AARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH--MAHPDAATT 528

Query: 370 YGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQ 429
            G TPLH++   G+ +VA  +++     SL  +  F  T  H A  YG S+D+ K LL +
Sbjct: 529 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF--TPLHVAAKYG-SLDVAKLLLQR 585

Query: 430 NVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMW 489
                +  G++G T LH A ++ + ++   LL+ GA  +  A         K+  T L  
Sbjct: 586 RAA-ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA---------KNGYTPLHI 635

Query: 490 AYEKGHDAIVTLLKHY 505
           A +K    I + L +Y
Sbjct: 636 AAKKNQMQIASTLLNY 651



 Score =  148 bits (374), Expect = 2e-35
 Identities = 104/324 (32%), Positives = 158/324 (48%), Gaps = 17/324 (5%)

Query: 180 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 239
           GK   ++ L+     P   T NG+T LH++  +   ++ + LL +GA        G T L
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 567

Query: 240 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGE 299
           H+A   G L+ A +LLQ  A  +       TPLH+AA+Y +++V  LLL+ GA  + + +
Sbjct: 568 HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK 627

Query: 300 VGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD 359
            G  PLH+A+ K  + IA  L+  G  A+ N    +   PLH  S+ GH D+V  LL   
Sbjct: 628 NGYTPLHIAAKKNQMQIASTLLNYG--AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 685

Query: 360 LEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKS 419
             +  H+    G T LHLA    K  VA +I+   G +      +   T    AC YG +
Sbjct: 686 ANI--HMSTKSGLTSLHLAAQEDKVNVA-DILTKHGADQDAHTKL-GYTPLIVACHYG-N 740

Query: 420 IDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSG 479
           + +V FLL Q   N+N + ++G+T LH A   GH  ++  LL +GA  N    + +    
Sbjct: 741 VKMVNFLLKQGA-NVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGN---- 795

Query: 480 EKDEQTCLMWAYEKGHDAIVTLLK 503
                T L  A   G+ ++V  LK
Sbjct: 796 -----TALAIAKRLGYISVVDTLK 814



 Score =  139 bits (349), Expect = 2e-32
 Identities = 113/420 (26%), Positives = 188/420 (44%), Gaps = 89/420 (21%)

Query: 158 KVNLNYRTENGLSLLHLCCICGGKKSHIRTLML---KGLRPSRLTRNGFTALHLAVYKDN 214
           + N N R  NG + LH+ C    KK+ I+ + L    G     +T +G T +H+A +  +
Sbjct: 388 RANPNARALNGFTPLHIAC----KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGH 443

Query: 215 AELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHI 274
             ++  LL +GA        G TALH+A  AG +E    LL++GA V+ +     TPLHI
Sbjct: 444 LNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503

Query: 275 AAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDN 334
           A+  G  ++ +LLL+  A  + +   G  PLH+++ +G +++A +L+E G+   +  +  
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK-- 561

Query: 335 EDHVPLHFCSRFGHHDIVKYLLQS-------------------------------DLEVQ 363
           +   PLH  +++G  D+ K LLQ                                +    
Sbjct: 562 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 621

Query: 364 PHVVNIYGDTPLHLACYNGKFEVAKEIIQISG-TESLTKENIFSETAFHSACTYGKSIDL 422
           PH     G TPLH+A    + ++A  ++     T  +TK+ +   T  H A   G + D+
Sbjct: 622 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV---TPLHLASQEGHT-DM 677

Query: 423 VKFLLDQNVININHQGRDGHTGLH---------------------------------SAC 449
           V  LLD+   NI+   + G T LH                                  AC
Sbjct: 678 VTLLLDKGA-NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVAC 736

Query: 450 YHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIV-TLLKHYKRP 508
           ++G++++V FLL  GA++N         +  K+  T L  A ++GH  I+  LL+H  +P
Sbjct: 737 HYGNVKMVNFLLKQGANVN---------AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787



 Score =  137 bits (344), Expect = 6e-32
 Identities = 101/324 (31%), Positives = 159/324 (49%), Gaps = 19/324 (5%)

Query: 196 SRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLL 255
           +R T +GFT LH+A +  N  + T LL+ GA +      G+T LH+A+  G+     +LL
Sbjct: 227 NRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLL 286

Query: 256 QHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLN 315
             G  ++ +     TPLH AA  GH+QV  LLL+ GA +    + G  PLH+A+    + 
Sbjct: 287 DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE 346

Query: 316 IAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL 375
             K L++   KA V+    +    LH  +  GH+ + K LL  D    P+   + G TPL
Sbjct: 347 CVKHLLQH--KAPVDDVTLDYLTALHVAAHCGHYRVTKLLL--DKRANPNARALNGFTPL 402

Query: 376 HLACYNGKFEVAKEIIQISGT-ESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVINI 434
           H+AC   + +V + +++   + +++T+  +   T  H A   G  +++V  LL QN  + 
Sbjct: 403 HIACKKNRIKVMELLVKYGASIQAITESGL---TPIHVAAFMGH-LNIVLLLL-QNGASP 457

Query: 435 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 494
           +     G T LH A   G + +V+ LL NGA ++  A         ++EQT L  A   G
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA---------REEQTPLHIASRLG 508

Query: 495 HDAIVTLLKHYKRPQDELPCNEYS 518
              IV LL  +    D    N Y+
Sbjct: 509 KTEIVQLLLQHMAHPDAATTNGYT 532



 Score =  132 bits (332), Expect = 2e-30
 Identities = 104/327 (31%), Positives = 156/327 (47%), Gaps = 25/327 (7%)

Query: 192 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAA 251
           G+  +   +NG  ALHLA  + +  L+  LL  G+ +      G TALHIA++AG  E  
Sbjct: 54  GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVV 113

Query: 252 DVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAK 311
            VL++ GAN+N Q    FTPL++AA   H  V + LL+ GA+ + + E G  PL +A  +
Sbjct: 114 KVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQ 173

Query: 312 GFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD--LEVQPHVV-- 367
           G      +L+E  +K  V          LH  +R         LLQ+D   +VQ  ++  
Sbjct: 174 GHNQAVAILLENDTKGKVRLP------ALHIAARKDDTKSAALLLQNDHNADVQSKMMVN 227

Query: 368 --NIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKF 425
                G TPLH+A + G   VA  ++        T  N    T  H A   G + ++VK 
Sbjct: 228 RTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN--GITPLHVASKRGNT-NMVKL 284

Query: 426 LLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQT 485
           LLD+    I+ + RDG T LH A   GH ++V+ LL+ GA +          +  K+  +
Sbjct: 285 LLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL---------LARTKNGLS 334

Query: 486 CLMWAYEKGHDAIVTLLKHYKRPQDEL 512
            L  A +  H   V  L  +K P D++
Sbjct: 335 PLHMAAQGDHVECVKHLLQHKAPVDDV 361



 Score =  123 bits (309), Expect = 7e-28
 Identities = 102/350 (29%), Positives = 160/350 (45%), Gaps = 52/350 (14%)

Query: 159 VNLNYRTENGLSLLHLCCICGGKKSHI---RTLMLKGLRPSRLTRNGFTALHLAVYKDNA 215
           +++N   +NGL+ LHL      K+ H+   + L+ +G      T+ G TALH+A     A
Sbjct: 55  IDINTCNQNGLNALHLAA----KEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 110

Query: 216 ELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIA 275
           E++  L+  GA+I      G T L++A    H++    LL++GAN +      FTPL +A
Sbjct: 111 EVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170

Query: 276 AYYGHEQVTRLLLK-------------------------------FGAD------VNVSG 298
              GH Q   +LL+                                 AD      VN + 
Sbjct: 171 LQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTT 230

Query: 299 EVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQS 358
           E G  PLH+A+  G +N+A LL+  G+  D  A++     PLH  S+ G+ ++VK LL  
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG--ITPLHVASKRGNTNMVKLLLDR 288

Query: 359 DLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGK 418
             ++     +  G TPLH A  +G  +V + +++         +N  S    H A   G 
Sbjct: 289 GGQIDAKTRD--GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS--PLHMA-AQGD 343

Query: 419 SIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 468
            ++ VK LL Q+   ++    D  T LH A + GH R+ + LLD  A+ N
Sbjct: 344 HVECVKHLL-QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN 392



 Score =  115 bits (289), Expect = 1e-25
 Identities = 78/265 (29%), Positives = 123/265 (46%), Gaps = 5/265 (1%)

Query: 165 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 224
           T+ G + LH+    G      + L+ +        +NG T LH+A + DN ++   LL  
Sbjct: 560 TKKGFTPLHVAAKYGSLDV-AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK 618

Query: 225 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT 284
           GA        G T LHIA     ++ A  LL +GA  NI      TPLH+A+  GH  + 
Sbjct: 619 GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMV 678

Query: 285 RLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCS 344
            LLL  GA++++S + G   LHLA+ +  +N+A +L + G  AD +A     + PL    
Sbjct: 679 TLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG--ADQDAHTKLGYTPLIVAC 736

Query: 345 RFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENI 404
            +G+  +V +LL+    V     N  G TPLH A   G   +   ++Q     + T  N 
Sbjct: 737 HYGNVKMVNFLLKQGANVNAKTKN--GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794

Query: 405 FSETAFHSACTYGKSIDLVKFLLDQ 429
            +  A      Y   +D +K + ++
Sbjct: 795 NTALAIAKRLGYISVVDTLKVVTEE 819



 Score =  107 bits (268), Expect = 4e-23
 Identities = 72/235 (30%), Positives = 119/235 (50%), Gaps = 15/235 (6%)

Query: 166 ENGLSLLHLCCICGGKKSHIR---TLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL 222
           +NG + LH+      KK+ ++   TL+  G   + +T+ G T LHLA  + + +++T LL
Sbjct: 627 KNGYTPLHIAA----KKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682

Query: 223 HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQ 282
             GA+I      GLT+LH+A     +  AD+L +HGA+ +    + +TPL +A +YG+ +
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 742

Query: 283 VTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHF 342
           +   LLK GA+VN   + G  PLH A+ +G  +I  +L++ G+K   NA     +  L  
Sbjct: 743 MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP--NATTANGNTALAI 800

Query: 343 CSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTE 397
             R G+  +V  L     EV      I     L++       E   E++ +S  E
Sbjct: 801 AKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVP------ETMTEVLDVSDEE 849



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 82/296 (27%), Positives = 134/296 (45%), Gaps = 50/296 (16%)

Query: 242 ATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVG 301
           A  AG+L+     L+ G ++N  +      LH+AA  GH  + + LL  G+ V+ + + G
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 302 DRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLE 361
           +  LH+AS  G   + K+L++EG  A++NAQ      PL+  ++  H D+VKYLL++   
Sbjct: 98  NTALHIASLAGQAEVVKVLVKEG--ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155

Query: 362 VQPHVVNIYGDTPLHLACYNG-------------KFEVAKEIIQISGTESLTKE------ 402
                 +  G TPL +A   G             K +V    + I+  +  TK       
Sbjct: 156 QSTATED--GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213

Query: 403 -------------NIFSETAF---HSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLH 446
                        N  +E+ F   H A  YG ++++   LL++    ++   R+G T LH
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYG-NVNVATLLLNRGAA-VDFTARNGITPLH 271

Query: 447 SACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
            A   G+  +V+ LLD G  ++         +  +D  T L  A   GHD +V LL
Sbjct: 272 VASKRGNTNMVKLLLDRGGQID---------AKTRDGLTPLHCAARSGHDQVVELL 318


>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
           sapiens]
          Length = 954

 Score =  155 bits (392), Expect = 2e-37
 Identities = 99/283 (34%), Positives = 149/283 (52%), Gaps = 21/283 (7%)

Query: 551 AGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKS-DVDMFCR 609
           AGL     +   E++  EIIG G FGKVY+   R + VA+K  R +     +   +  C+
Sbjct: 85  AGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQ 144

Query: 610 EVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLII-- 667
           E  +   L HP +I   GACLN P    +V +Y  GG+L  +L  ++    +   +++  
Sbjct: 145 EARLFGALQHPNIIALRGACLNPP-HLCLVMEYARGGALSRVLAGRR----VPPHVLVNW 199

Query: 668 AVDVAKGMEYLHN-LTQPIIHRDLNSHNILLYE--------DGHAVVADFGESRFLQSLD 718
           AV VA+GM YLHN    PIIHRDL S NIL+ E        D    + DFG +R      
Sbjct: 200 AVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR---EWH 256

Query: 719 EDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADM 778
           +       G   WMAPEV  + + ++  +DV+S+ + LWE+LTGE+P+  +   A A  +
Sbjct: 257 KTTKMSAAGTYAWMAPEVI-RLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGV 315

Query: 779 AYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLE 821
           A + +  PI  + P+P + LL   W+  P GRP+F  ++ +LE
Sbjct: 316 AMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLE 358


>gi|21735566 mitogen-activated protein kinase kinase kinase 7
           isoform D [Homo sapiens]
          Length = 491

 Score =  155 bits (391), Expect = 2e-37
 Identities = 96/264 (36%), Positives = 147/264 (55%), Gaps = 18/264 (6%)

Query: 559 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 618
           +   EIE  E++G G+FG V K + R K VAIK+       S+S+   F  E+  L ++N
Sbjct: 31  IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIE-----SESERKAFIVELRQLSRVN 85

Query: 619 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGME 676
           HP +++  GACLN      +V +Y  GGSL+++LH  E          +   +  ++G+ 
Sbjct: 86  HPNIVKLYGACLNP---VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142

Query: 677 YLHNLT-QPIIHRDLNSHNILLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAP 734
           YLH++  + +IHRDL   N+LL   G  + + DFG +  +Q+    +MT   G+  WMAP
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT----HMTNNKGSAAWMAP 198

Query: 735 EVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHH-IRPPIGYSIPK 793
           EVF + + Y+ K DVFS+ + LWE++T   PF  +   A     A H+  RPP+  ++PK
Sbjct: 199 EVF-EGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPK 257

Query: 794 PISSLLIRGWNACPEGRPEFSEVV 817
           PI SL+ R W+  P  RP   E+V
Sbjct: 258 PIESLMTRCWSKDPSQRPSMEEIV 281


>gi|21735564 mitogen-activated protein kinase kinase kinase 7
           isoform C [Homo sapiens]
          Length = 518

 Score =  155 bits (391), Expect = 2e-37
 Identities = 96/264 (36%), Positives = 147/264 (55%), Gaps = 18/264 (6%)

Query: 559 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 618
           +   EIE  E++G G+FG V K + R K VAIK+       S+S+   F  E+  L ++N
Sbjct: 31  IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIE-----SESERKAFIVELRQLSRVN 85

Query: 619 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGME 676
           HP +++  GACLN      +V +Y  GGSL+++LH  E          +   +  ++G+ 
Sbjct: 86  HPNIVKLYGACLNP---VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142

Query: 677 YLHNLT-QPIIHRDLNSHNILLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAP 734
           YLH++  + +IHRDL   N+LL   G  + + DFG +  +Q+    +MT   G+  WMAP
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT----HMTNNKGSAAWMAP 198

Query: 735 EVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHH-IRPPIGYSIPK 793
           EVF + + Y+ K DVFS+ + LWE++T   PF  +   A     A H+  RPP+  ++PK
Sbjct: 199 EVF-EGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPK 257

Query: 794 PISSLLIRGWNACPEGRPEFSEVV 817
           PI SL+ R W+  P  RP   E+V
Sbjct: 258 PIESLMTRCWSKDPSQRPSMEEIV 281


>gi|21735562 mitogen-activated protein kinase kinase kinase 7
           isoform B [Homo sapiens]
          Length = 606

 Score =  155 bits (391), Expect = 2e-37
 Identities = 96/264 (36%), Positives = 147/264 (55%), Gaps = 18/264 (6%)

Query: 559 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 618
           +   EIE  E++G G+FG V K + R K VAIK+       S+S+   F  E+  L ++N
Sbjct: 31  IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIE-----SESERKAFIVELRQLSRVN 85

Query: 619 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGME 676
           HP +++  GACLN      +V +Y  GGSL+++LH  E          +   +  ++G+ 
Sbjct: 86  HPNIVKLYGACLNP---VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142

Query: 677 YLHNLT-QPIIHRDLNSHNILLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAP 734
           YLH++  + +IHRDL   N+LL   G  + + DFG +  +Q+    +MT   G+  WMAP
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT----HMTNNKGSAAWMAP 198

Query: 735 EVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHH-IRPPIGYSIPK 793
           EVF + + Y+ K DVFS+ + LWE++T   PF  +   A     A H+  RPP+  ++PK
Sbjct: 199 EVF-EGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPK 257

Query: 794 PISSLLIRGWNACPEGRPEFSEVV 817
           PI SL+ R W+  P  RP   E+V
Sbjct: 258 PIESLMTRCWSKDPSQRPSMEEIV 281


>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
           A [Homo sapiens]
          Length = 579

 Score =  155 bits (391), Expect = 2e-37
 Identities = 96/264 (36%), Positives = 147/264 (55%), Gaps = 18/264 (6%)

Query: 559 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 618
           +   EIE  E++G G+FG V K + R K VAIK+       S+S+   F  E+  L ++N
Sbjct: 31  IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIE-----SESERKAFIVELRQLSRVN 85

Query: 619 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGME 676
           HP +++  GACLN      +V +Y  GGSL+++LH  E          +   +  ++G+ 
Sbjct: 86  HPNIVKLYGACLNP---VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142

Query: 677 YLHNLT-QPIIHRDLNSHNILLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAP 734
           YLH++  + +IHRDL   N+LL   G  + + DFG +  +Q+    +MT   G+  WMAP
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT----HMTNNKGSAAWMAP 198

Query: 735 EVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHH-IRPPIGYSIPK 793
           EVF + + Y+ K DVFS+ + LWE++T   PF  +   A     A H+  RPP+  ++PK
Sbjct: 199 EVF-EGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPK 257

Query: 794 PISSLLIRGWNACPEGRPEFSEVV 817
           PI SL+ R W+  P  RP   E+V
Sbjct: 258 PIESLMTRCWSKDPSQRPSMEEIV 281


>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
          Length = 455

 Score =  141 bits (356), Expect = 2e-33
 Identities = 93/271 (34%), Positives = 139/271 (51%), Gaps = 20/271 (7%)

Query: 555 SHFHLQLSEIEFHEIIGSGSFGKVYKGR--CRNKIVAIKRYRANTYCSKSDVDMFCREVS 612
           S   ++  +++F E  G GSFG VY+ +   ++K VA+K+                +E  
Sbjct: 7   SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----------KEAE 55

Query: 613 ILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQK-RILDLQSKLIIAVDV 671
           IL  L+H  +IQF G  L +P  + IVT+Y S GSL+  ++  +   +D+   +  A DV
Sbjct: 56  ILSVLSHRNIIQFYGVIL-EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDV 114

Query: 672 AKGMEYLH-NLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLR 730
           AKGM YLH      +IHRDL S N+++  DG   + DFG SRF       ++    G   
Sbjct: 115 AKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLV---GTFP 171

Query: 731 WMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS 790
           WMAPEV  Q    +   D +SY + LWE+LT E+PF  L+    A  +   + R  I  S
Sbjct: 172 WMAPEVI-QSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSS 230

Query: 791 IPKPISSLLIRGWNACPEGRPEFSEVVMKLE 821
            P+  + LL + W A  + RP F +++  LE
Sbjct: 231 CPRSFAELLHQCWEADAKKRPSFKQIISILE 261


>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
          Length = 800

 Score =  141 bits (356), Expect = 2e-33
 Identities = 93/271 (34%), Positives = 139/271 (51%), Gaps = 20/271 (7%)

Query: 555 SHFHLQLSEIEFHEIIGSGSFGKVYKGR--CRNKIVAIKRYRANTYCSKSDVDMFCREVS 612
           S   ++  +++F E  G GSFG VY+ +   ++K VA+K+                +E  
Sbjct: 7   SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----------KEAE 55

Query: 613 ILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQK-RILDLQSKLIIAVDV 671
           IL  L+H  +IQF G  L +P  + IVT+Y S GSL+  ++  +   +D+   +  A DV
Sbjct: 56  ILSVLSHRNIIQFYGVIL-EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDV 114

Query: 672 AKGMEYLH-NLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLR 730
           AKGM YLH      +IHRDL S N+++  DG   + DFG SRF       ++    G   
Sbjct: 115 AKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLV---GTFP 171

Query: 731 WMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS 790
           WMAPEV  Q    +   D +SY + LWE+LT E+PF  L+    A  +   + R  I  S
Sbjct: 172 WMAPEVI-QSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSS 230

Query: 791 IPKPISSLLIRGWNACPEGRPEFSEVVMKLE 821
            P+  + LL + W A  + RP F +++  LE
Sbjct: 231 CPRSFAELLHQCWEADAKKRPSFKQIISILE 261


>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
           sapiens]
          Length = 847

 Score =  139 bits (349), Expect = 2e-32
 Identities = 89/271 (32%), Positives = 140/271 (51%), Gaps = 21/271 (7%)

Query: 563 EIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKS-DVDMFCREVSILCQLNHPC 621
           E+   E+IG G FGKVY+G  R ++VA+K  R +     S   +   +E  +   L HP 
Sbjct: 116 ELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPN 175

Query: 622 VIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLII--AVDVAKGMEYLH 679
           +I     CL +P+   +V +Y +GG L   L  ++    +   +++  AV +A+GM YLH
Sbjct: 176 IIALKAVCLEEPN-LCLVMEYAAGGPLSRALAGRR----VPPHVLVNWAVQIARGMHYLH 230

Query: 680 -NLTQPIIHRDLNSHNILLY--------EDGHAVVADFGESRFLQSLDEDNMTKQPGNLR 730
                P+IHRDL S+NILL         E     + DFG +R      +       G   
Sbjct: 231 CEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAR---EWHKTTQMSAAGTYA 287

Query: 731 WMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS 790
           WMAPEV    T ++  +DV+S+ + LWE+LTGE+P+  +   A A  +A + +  PI  +
Sbjct: 288 WMAPEVIKAST-FSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPST 346

Query: 791 IPKPISSLLIRGWNACPEGRPEFSEVVMKLE 821
            P+P + L+   W   P  RP+F+ ++ +LE
Sbjct: 347 CPEPFAQLMADCWAQDPHRRPDFASILQQLE 377


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  137 bits (345), Expect = 5e-32
 Identities = 103/340 (30%), Positives = 167/340 (49%), Gaps = 19/340 (5%)

Query: 166 ENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSG 225
           ++G SLLHL  +  G++   + L+L    P+   R G T LH+AV +    ++  LL   
Sbjct: 436 DSGASLLHLA-VEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARK 494

Query: 226 ADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTR 285
             +        TALH A   G   +  +LL+  A+VN  D    TP+H+A  +G E + R
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554

Query: 286 LLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSR 345
           +LL+ G DV++ G+    PLH A+ +G L I KLL ++     VNAQ  +   PLH  ++
Sbjct: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPG-VSVNAQTLDGRTPLHLAAQ 613

Query: 346 FGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII-QISGTESLTKENI 404
            GH+ + + L+  DL    +V ++   TPLH+A   G    A+ ++ + +G E++T +  
Sbjct: 614 RGHYRVARILI--DLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGY 671

Query: 405 FSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNG 464
              TA H A   G  +  VK L+++   ++  +G    T LH A  HGH  +V+      
Sbjct: 672 ---TALHLAARNG-HLATVKLLVEEKA-DVLARGPLNQTALHLAAAHGHSEVVE------ 720

Query: 465 ADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKH 504
               LV+ D      E+      + A  +    + TLL+H
Sbjct: 721 ---ELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRH 757



 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 76/269 (28%), Positives = 129/269 (47%), Gaps = 18/269 (6%)

Query: 568 EIIGSGSFGKVYKGRCRN--KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQF 625
           E +GSG FG+VYK R  +    +AIK   +     +  +++   E   +       ++  
Sbjct: 26  EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELL-EEAKKMEMAKFRYILPV 84

Query: 626 VGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPI 685
            G C  +P    +V +Y+  GSL  LL  +    DL+ ++I   + A GM +LH +  P+
Sbjct: 85  YGIC-REP--VGLVMEYMETGSLEKLLASEPLPWDLRFRIIH--ETAVGMNFLHCMAPPL 139

Query: 686 IHRDLNSHNILLYEDGHAVVADFGESRF--LQSLDEDNMTKQPGNLRWMAPEVFTQCTR- 742
           +H DL   NILL    H  ++DFG ++   L    + +M    G + ++ PE   + +R 
Sbjct: 140 LHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRL 199

Query: 743 YTIKADVFSYALCLWEILTGEIPFA---HLKPAAAAADMAYHHIRPPIGYSIPKPIS--- 796
           +  K DV+S+A+ +W +LT + PFA   ++          +    PP+  + P+  S   
Sbjct: 200 FDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARPRACSHLI 259

Query: 797 SLLIRGWNACPEGRPEFSEVVMKLEECLC 825
            L+ R W   P  RP F E+  + E+ LC
Sbjct: 260 RLMQRCWQGDPRVRPTFQEITSETED-LC 287



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 38/117 (32%), Positives = 58/117 (49%), Gaps = 1/117 (0%)

Query: 180 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 239
           G  S  R L+ +G     +T +G+TALHLA    +   +  L+   AD+   G    TAL
Sbjct: 648 GHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTAL 707

Query: 240 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNV 296
           H+A   GH E  + L+     +++ D    + LH+AA   H Q    LL+ GA +N+
Sbjct: 708 HLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINL 763



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 8/107 (7%)

Query: 165 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNG---FTALHLAVYKDNAELITSL 221
           T +G + LHL      +  H+ T+ L     + +   G    TALHLA    ++E++  L
Sbjct: 667 TSDGYTALHLAA----RNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEEL 722

Query: 222 LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVF 268
           + +   I      GL+ALH+A    H +  + LL+HGA++N+Q   F
Sbjct: 723 VSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKF 768


>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
           sapiens]
          Length = 1118

 Score =  135 bits (341), Expect = 1e-31
 Identities = 95/277 (34%), Positives = 142/277 (51%), Gaps = 22/277 (7%)

Query: 559 LQLSEIEF-----HEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD-VDMFCREVS 612
           +QL EI+F      EIIG G FGKVY+       VA+K  R +     S  ++   +E  
Sbjct: 134 IQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAK 193

Query: 613 ILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVA 672
           +   L HP +I   G CL +P+   +V ++  GG L  +L  ++   D+      AV +A
Sbjct: 194 LFAMLKHPNIIALRGVCLKEPN-LCLVMEFARGGPLNRVLSGKRIPPDILVNW--AVQIA 250

Query: 673 KGMEYLHN-LTQPIIHRDLNSHNILLY---EDGHAV-----VADFGESRFLQSLDEDNMT 723
           +GM YLH+    PIIHRDL S NIL+    E+G        + DFG +R           
Sbjct: 251 RGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR---EWHRTTKM 307

Query: 724 KQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHI 783
              G   WMAPEV  + + ++  +DV+SY + LWE+LTGE+PF  +   A A  +A + +
Sbjct: 308 SAAGTYAWMAPEVI-RASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKL 366

Query: 784 RPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKL 820
             PI  + P+P + L+   WN  P  RP F+ ++ +L
Sbjct: 367 ALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL 403


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  135 bits (339), Expect = 2e-31
 Identities = 100/351 (28%), Positives = 163/351 (46%), Gaps = 49/351 (13%)

Query: 185 IRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATI 244
           +R+L+ +    + L +   T LH A Y  +  ++  LL SGA++       LT LH A  
Sbjct: 24  VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAA 83

Query: 245 AGHLEAADVLLQHGANVNIQDAVFFTPLHIAA---------------------------- 276
           + + +   +LL H A+VN +D ++ TPLH+AA                            
Sbjct: 84  SRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSA 143

Query: 277 -----YYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNA 331
                + GH +   LLL  GA +NV  +   +PLH A+  G L + KLL+  G  AD+  
Sbjct: 144 LHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARG--ADLGC 201

Query: 332 QDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII 391
           +D + +  LH  +  G  ++VKYLL+   E+     N +G+T LH+ACY G+  VA E++
Sbjct: 202 KDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEP--NAFGNTALHIACYLGQDAVAIELV 259

Query: 392 QISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYH 451
                 +   +  F+     +  T G    L   LL  N  ++N+Q ++G + LH A  H
Sbjct: 260 NAGANVNQPNDKGFTPLHVAAVSTNGA---LCLELLVNNGADVNYQSKEGKSPLHMAAIH 316

Query: 452 GHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
           G     Q L+ NG++++           +K   T L  A   GH+ +++ L
Sbjct: 317 GRFTRSQILIQNGSEID---------CADKFGNTPLHVAARYGHELLISTL 358



 Score =  114 bits (285), Expect = 4e-25
 Identities = 84/288 (29%), Positives = 136/288 (47%), Gaps = 32/288 (11%)

Query: 185 IRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATI 244
           ++ L+ +G       R G+  LH A      E++  LL  GA+I +    G TALHIA  
Sbjct: 189 LKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACY 248

Query: 245 AGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVT-RLLLKFGADVNVSGEVGDR 303
            G    A  L+  GANVN  +   FTPLH+AA   +  +   LL+  GADVN   + G  
Sbjct: 249 LGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKS 308

Query: 304 PLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQ 363
           PLH+A+  G    +++L++ GS+ D    D   + PLH  +R+GH  ++  L+ +  +  
Sbjct: 309 PLHMAAIHGRFTRSQILIQNGSEID--CADKFGNTPLHVAARYGHELLISTLMTNGADTA 366

Query: 364 PHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLV 423
                I+   PLHLA   G  +  ++++                       + G+   +V
Sbjct: 367 RR--GIHDMFPLHLAVLFGFSDCCRKLL-----------------------SSGQLYSIV 401

Query: 424 KFLLDQNVIN----INHQGRDGHTGLHSACYHGHIRLVQFLLDNGADM 467
             L +++V++    IN     G T LH+A   G++  +  LL +GAD+
Sbjct: 402 SSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADL 449



 Score =  110 bits (275), Expect = 6e-24
 Identities = 90/337 (26%), Positives = 147/337 (43%), Gaps = 46/337 (13%)

Query: 168 GLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLL-HSGA 226
           G + LH+ C  G     I  L+  G   ++    GFT LH+A    N  L   LL ++GA
Sbjct: 239 GNTALHIACYLGQDAVAIE-LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGA 297

Query: 227 DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRL 286
           D+      G + LH+A I G    + +L+Q+G+ ++  D    TPLH+AA YGHE +   
Sbjct: 298 DVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLIST 357

Query: 287 LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEG----------------SKADVN 330
           L+  GAD    G     PLHLA   GF +  + L+  G                +  D+N
Sbjct: 358 LMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDIN 417

Query: 331 AQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEI 390
             DN     LH  +  G+ + +  LL S  +++    + +G TPLH A  NG ++ A  +
Sbjct: 418 TPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRR--DKFGRTPLHYAAANGSYQCAVTL 475

Query: 391 IQ------------ISGTESLTKENIFSETAFHSACTYGKSID-------------LVKF 425
           +              S        + +     H+  ++    D              ++F
Sbjct: 476 VTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEF 535

Query: 426 LLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLD 462
           LLD N  + + + R G+T +H A  +G+ + ++ LL+
Sbjct: 536 LLD-NGADPSLRDRQGYTAVHYAAAYGNRQNLELLLE 571



 Score =  102 bits (254), Expect = 2e-21
 Identities = 95/334 (28%), Positives = 143/334 (42%), Gaps = 49/334 (14%)

Query: 206 LHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQD 265
           LHLA Y  + E + +L  +  ++    + G TAL +AT  G  E  +VL  HGA+  I++
Sbjct: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648

Query: 266 AV-FFTPLHIAAYYGHEQVTRLLLKFG--ADV-NVSGEVGDRPLHLASAKGFLNIAKLLM 321
               +TPLH AA  GH     LL+  G  AD+ +V    G  PL LA   G ++   LL+
Sbjct: 649 RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL 708

Query: 322 EEGSKAD-------------------------------VNAQDNEDHVPLHFCSRFGHHD 350
           E+GS AD                               V  +D +   P+H  S  GH  
Sbjct: 709 EKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTA 768

Query: 351 IVKYLLQSDLEVQP--HVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSET 408
           +++ LLQ+ L   P    V+  G +P+H A Y G  E   E++      S  + N F  T
Sbjct: 769 VLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTG-HEDCLELLLEHSPFSYLEGNPF--T 825

Query: 409 AFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 468
             H A    +       L       +N +   G T LH+A +  ++  ++ LL + A++N
Sbjct: 826 PLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVN 885

Query: 469 LVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
                    + +   +T LM A E G  A V  L
Sbjct: 886 ---------ATDHTGRTALMTAAENGQTAAVEFL 910



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 107/421 (25%), Positives = 161/421 (38%), Gaps = 89/421 (21%)

Query: 160 NLNYRTENGLSLLHLCCICG--------------------------------GKKSHIRT 187
           ++NY+++ G S LH+  I G                                G +  I T
Sbjct: 298 DVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLIST 357

Query: 188 LMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGA------------------DIQ 229
           LM  G   +R   +    LHLAV    ++    LL SG                   DI 
Sbjct: 358 LMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDIN 417

Query: 230 QVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLK 289
                G T LH A   G++E  ++LL  GA++  +D    TPLH AA  G  Q    L+ 
Sbjct: 418 TPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVT 477

Query: 290 FGADVNVSGEVGDRPLHLASAKGFLNIA----------------------------KLLM 321
            GA VN +   G  PLH A+A      A                            + L+
Sbjct: 478 AGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLL 537

Query: 322 EEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYN 381
           + G  AD + +D + +  +H+ + +G+   ++ LL+        V +    +PLHLA YN
Sbjct: 538 DNG--ADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYN 595

Query: 382 GKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDG 441
           G  E  K + +     +L   +    TA   A   G S + V+ L       +  + +  
Sbjct: 596 GHCEALKTLAET--LVNLDVRDHKGRTALFLATERG-STECVEVLTAHGASALIKERKRK 652

Query: 442 HTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTL 501
            T LH+A   GH   +  L+D+G   ++   D   + G    QT LM A   GH   V L
Sbjct: 653 WTPLHAAAASGHTDSLHLLIDSGERADIT--DVMDAYG----QTPLMLAIMNGHVDCVHL 706

Query: 502 L 502
           L
Sbjct: 707 L 707



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 77/288 (26%), Positives = 131/288 (45%), Gaps = 14/288 (4%)

Query: 221 LLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANV--NIQDAVFFTPLHIAAYY 278
           LL +GAD       G TA+H A   G+ +  ++LL+   N   +++  +  +PLH+AAY 
Sbjct: 536 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYN 595

Query: 279 GHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHV 338
           GH +  + L +   +++V    G   L LA+ +G     ++L   G+ A +  +  +   
Sbjct: 596 GHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRK-WT 654

Query: 339 PLHFCSRFGHHDIVKYLLQSDLEVQ-PHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTE 397
           PLH  +  GH D +  L+ S        V++ YG TPL LA  NG  +    +++   T 
Sbjct: 655 PLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTA 714

Query: 398 SLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLV 457
                ++   TA H     G   D +  LLD +   +    + G T +H A   GH  ++
Sbjct: 715 DAA--DLRGRTALHRGAVTGCE-DCLAALLDHDAFVLCRDFK-GRTPIHLASACGHTAVL 770

Query: 458 QFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH-DAIVTLLKH 504
           + LL        ++ DP  +  +    + + WA   GH D +  LL+H
Sbjct: 771 RTLLQAA-----LSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH 813



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 90/328 (27%), Positives = 135/328 (41%), Gaps = 23/328 (7%)

Query: 174  LCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGY 233
            +  I  G    +  L+ KG         G TALH        + + +LL   A +    +
Sbjct: 693  MLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDF 752

Query: 234  GGLTALHIATIAGHLEAADVLLQHGANVNIQDAVF----FTPLHIAAYYGHEQVTRLLLK 289
             G T +H+A+  GH      LLQ   + +  DA      ++P+H A+Y GHE    LLL+
Sbjct: 753  KGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE 812

Query: 290  FGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHH 349
                  + G     PLH A      +  ++L+       VN++D +   PLH  +   + 
Sbjct: 813  HSPFSYLEGN-PFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNV 871

Query: 350  DIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETA 409
              ++ LLQ   EV  +  +  G T L  A  NG+   A E +   G   LT  +    TA
Sbjct: 872  SGLRMLLQHQAEV--NATDHTGRTALMTAAENGQ-TAAVEFLLYRGKADLTVLDENKNTA 928

Query: 410  FHSACTYGKSIDLVKFLLD-QNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 468
             H AC+ G     +  L + Q++  IN         LH A  +G   +VQ LL +GA + 
Sbjct: 929  LHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVL 988

Query: 469  LV---------ACDPSRSSGEKDEQTCL 487
             V         AC P+     KD   CL
Sbjct: 989  AVDEEGHTPALACAPN-----KDVADCL 1011



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 77/279 (27%), Positives = 120/279 (43%), Gaps = 22/279 (7%)

Query: 202 GFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANV 261
           G T L LA+   + + +  LL  G+        G TALH   + G  +    LL H A V
Sbjct: 688 GQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFV 747

Query: 262 NIQDAVFFTPLHIAAYYGHEQVTRLLLK-------FGADVNVSGEVGDRPLHLASAKGFL 314
             +D    TP+H+A+  GH  V R LL+         A V+ SG     P+H AS  G  
Sbjct: 748 LCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGY---SPMHWASYTGHE 804

Query: 315 NIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVN---IYG 371
           +  +LL+E    +  +  +     PLH C+   + D    +L   L  +  +VN     G
Sbjct: 805 DCLELLLEH---SPFSYLEGNPFTPLH-CAVINNQDSTTEMLLGALGAK--IVNSRDAKG 858

Query: 372 DTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNV 431
            TPLH A +       + ++Q     + T       TA  +A   G++   V+FLL +  
Sbjct: 859 RTPLHAAAFADNVSGLRMLLQHQAEVNATDHT--GRTALMTAAENGQTA-AVEFLLYRGK 915

Query: 432 ININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLV 470
            ++     + +T LH AC  GH +    +L    D+ L+
Sbjct: 916 ADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLI 954



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 60/232 (25%), Positives = 94/232 (40%), Gaps = 50/232 (21%)

Query: 271 PLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVN 330
           PL  A +    +  R LL    ++NV  +    PLH A+  G + I +LL+  G  A+VN
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSG--ANVN 68

Query: 331 AQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEI 390
           A+D     PLH  +   +  ++  LL    +V     +    TPLH+A  N   + A+ +
Sbjct: 69  AKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNAR--DKLWQTPLHVAAANRATKCAEAL 126

Query: 391 IQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACY 450
             +                                     + ++N   R G + LH A +
Sbjct: 127 APL-------------------------------------LSSLNVADRSGRSALHHAVH 149

Query: 451 HGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
            GH+  V  LL+ GA +N+  CD       K E+  L WA   GH  ++ LL
Sbjct: 150 SGHLETVNLLLNKGASLNV--CD-------KKERQPLHWAAFLGHLEVLKLL 192


>gi|62420875 integrin-linked kinase [Homo sapiens]
          Length = 452

 Score =  134 bits (336), Expect = 5e-31
 Identities = 123/514 (23%), Positives = 220/514 (42%), Gaps = 86/514 (16%)

Query: 316 IAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL 375
           +A  L  + ++ D+N  D+    PLH+  R G   +V+ L+     +  +V+N   DTPL
Sbjct: 14  VAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI--NVMNRGDDTPL 71

Query: 376 HLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININ 435
           HLA  +G  ++ ++++Q                                +  D N +N  
Sbjct: 72  HLAASHGHRDIVQKLLQ--------------------------------YKADINAVN-- 97

Query: 436 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 495
                G+  LH AC+ G  ++ + L+ NGA +++         GE               
Sbjct: 98  ---EHGNVPLHYACFWGQDQVAEDLVANGALVSI-----CNKYGEMP------------- 136

Query: 496 DAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPS 555
                 +   K P  EL      + G + + +       K  + T+ +         L  
Sbjct: 137 ------VDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPR------NGTLNK 184

Query: 556 HFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILC 615
           H  +   ++ F   +     G+++KGR +   + +K  +   + ++   D F  E   L 
Sbjct: 185 HSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRD-FNEECPRLR 243

Query: 616 QLNHPCVIQFVGACLNDPSQF-AIVTQYISGGSLFSLLHEQKRILDLQSKLI-IAVDVAK 673
             +HP V+  +GAC + P+    ++T ++  GSL+++LHE    +  QS+ +  A+D+A+
Sbjct: 244 IFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMAR 303

Query: 674 GMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNL---R 730
           GM +LH L   I    LNS ++++ ED  A ++           D     + PG +    
Sbjct: 304 GMAFLHTLEPLIPRHALNSRSVMIDEDMTARIS---------MADVKFSFQCPGRMYAPA 354

Query: 731 WMAPEVFTQCTRYTIK--ADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIG 788
           W+APE   +    T +  AD++S+A+ LWE++T E+PFA L        +A   +RP I 
Sbjct: 355 WVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIP 414

Query: 789 YSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEE 822
             I   +  L+    N  P  RP+F  +V  LE+
Sbjct: 415 PGISPHVCKLMKICMNEDPAKRPKFDMIVPILEK 448



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 34/99 (34%), Positives = 59/99 (59%), Gaps = 4/99 (4%)

Query: 293 DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIV 352
           D+N   + G  PLH A  +G   + ++L+  G++  +N  +  D  PLH  +  GH DIV
Sbjct: 26  DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGAR--INVMNRGDDTPLHLAASHGHRDIV 83

Query: 353 KYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII 391
           + LLQ   ++  + VN +G+ PLH AC+ G+ +VA++++
Sbjct: 84  QKLLQYKADI--NAVNEHGNVPLHYACFWGQDQVAEDLV 120



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 41/130 (31%), Positives = 66/130 (50%), Gaps = 4/130 (3%)

Query: 201 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 260
           +GF+ LH A  +  + ++  L+  GA I  +  G  T LH+A   GH +    LLQ+ A+
Sbjct: 33  HGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKAD 92

Query: 261 VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLL 320
           +N  +     PLH A ++G +QV   L+  GA V++  + G+ P+  A A     + +LL
Sbjct: 93  INAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAP----LRELL 148

Query: 321 MEEGSKADVN 330
            E   K   N
Sbjct: 149 RERAEKMGQN 158



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 34/103 (33%), Positives = 55/103 (53%)

Query: 227 DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRL 286
           D+ Q    G + LH A   G     ++L+  GA +N+ +    TPLH+AA +GH  + + 
Sbjct: 26  DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQK 85

Query: 287 LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADV 329
           LL++ AD+N   E G+ PLH A   G   +A+ L+  G+   +
Sbjct: 86  LLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSI 128



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 40/136 (29%), Positives = 65/136 (47%), Gaps = 1/136 (0%)

Query: 160 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 219
           +LN   ++G S LH  C   G+ + +  L+++G R + + R   T LHLA    + +++ 
Sbjct: 26  DLNQGDDHGFSPLHWACR-EGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQ 84

Query: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279
            LL   ADI  V   G   LH A   G  + A+ L+ +GA V+I +     P+  A    
Sbjct: 85  KLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPL 144

Query: 280 HEQVTRLLLKFGADVN 295
            E +     K G ++N
Sbjct: 145 RELLRERAEKMGQNLN 160


>gi|62420873 integrin-linked kinase [Homo sapiens]
          Length = 452

 Score =  134 bits (336), Expect = 5e-31
 Identities = 123/514 (23%), Positives = 220/514 (42%), Gaps = 86/514 (16%)

Query: 316 IAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL 375
           +A  L  + ++ D+N  D+    PLH+  R G   +V+ L+     +  +V+N   DTPL
Sbjct: 14  VAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI--NVMNRGDDTPL 71

Query: 376 HLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININ 435
           HLA  +G  ++ ++++Q                                +  D N +N  
Sbjct: 72  HLAASHGHRDIVQKLLQ--------------------------------YKADINAVN-- 97

Query: 436 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 495
                G+  LH AC+ G  ++ + L+ NGA +++         GE               
Sbjct: 98  ---EHGNVPLHYACFWGQDQVAEDLVANGALVSI-----CNKYGEMP------------- 136

Query: 496 DAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPS 555
                 +   K P  EL      + G + + +       K  + T+ +         L  
Sbjct: 137 ------VDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPR------NGTLNK 184

Query: 556 HFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILC 615
           H  +   ++ F   +     G+++KGR +   + +K  +   + ++   D F  E   L 
Sbjct: 185 HSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRD-FNEECPRLR 243

Query: 616 QLNHPCVIQFVGACLNDPSQF-AIVTQYISGGSLFSLLHEQKRILDLQSKLI-IAVDVAK 673
             +HP V+  +GAC + P+    ++T ++  GSL+++LHE    +  QS+ +  A+D+A+
Sbjct: 244 IFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMAR 303

Query: 674 GMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNL---R 730
           GM +LH L   I    LNS ++++ ED  A ++           D     + PG +    
Sbjct: 304 GMAFLHTLEPLIPRHALNSRSVMIDEDMTARIS---------MADVKFSFQCPGRMYAPA 354

Query: 731 WMAPEVFTQCTRYTIK--ADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIG 788
           W+APE   +    T +  AD++S+A+ LWE++T E+PFA L        +A   +RP I 
Sbjct: 355 WVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIP 414

Query: 789 YSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEE 822
             I   +  L+    N  P  RP+F  +V  LE+
Sbjct: 415 PGISPHVCKLMKICMNEDPAKRPKFDMIVPILEK 448



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 34/99 (34%), Positives = 59/99 (59%), Gaps = 4/99 (4%)

Query: 293 DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIV 352
           D+N   + G  PLH A  +G   + ++L+  G++  +N  +  D  PLH  +  GH DIV
Sbjct: 26  DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGAR--INVMNRGDDTPLHLAASHGHRDIV 83

Query: 353 KYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII 391
           + LLQ   ++  + VN +G+ PLH AC+ G+ +VA++++
Sbjct: 84  QKLLQYKADI--NAVNEHGNVPLHYACFWGQDQVAEDLV 120



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 41/130 (31%), Positives = 66/130 (50%), Gaps = 4/130 (3%)

Query: 201 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 260
           +GF+ LH A  +  + ++  L+  GA I  +  G  T LH+A   GH +    LLQ+ A+
Sbjct: 33  HGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKAD 92

Query: 261 VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLL 320
           +N  +     PLH A ++G +QV   L+  GA V++  + G+ P+  A A     + +LL
Sbjct: 93  INAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAP----LRELL 148

Query: 321 MEEGSKADVN 330
            E   K   N
Sbjct: 149 RERAEKMGQN 158



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 34/103 (33%), Positives = 55/103 (53%)

Query: 227 DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRL 286
           D+ Q    G + LH A   G     ++L+  GA +N+ +    TPLH+AA +GH  + + 
Sbjct: 26  DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQK 85

Query: 287 LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADV 329
           LL++ AD+N   E G+ PLH A   G   +A+ L+  G+   +
Sbjct: 86  LLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSI 128



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 40/136 (29%), Positives = 65/136 (47%), Gaps = 1/136 (0%)

Query: 160 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 219
           +LN   ++G S LH  C   G+ + +  L+++G R + + R   T LHLA    + +++ 
Sbjct: 26  DLNQGDDHGFSPLHWACR-EGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQ 84

Query: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279
            LL   ADI  V   G   LH A   G  + A+ L+ +GA V+I +     P+  A    
Sbjct: 85  KLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPL 144

Query: 280 HEQVTRLLLKFGADVN 295
            E +     K G ++N
Sbjct: 145 RELLRERAEKMGQNLN 160


>gi|4758606 integrin-linked kinase [Homo sapiens]
          Length = 452

 Score =  134 bits (336), Expect = 5e-31
 Identities = 123/514 (23%), Positives = 220/514 (42%), Gaps = 86/514 (16%)

Query: 316 IAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL 375
           +A  L  + ++ D+N  D+    PLH+  R G   +V+ L+     +  +V+N   DTPL
Sbjct: 14  VAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI--NVMNRGDDTPL 71

Query: 376 HLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININ 435
           HLA  +G  ++ ++++Q                                +  D N +N  
Sbjct: 72  HLAASHGHRDIVQKLLQ--------------------------------YKADINAVN-- 97

Query: 436 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 495
                G+  LH AC+ G  ++ + L+ NGA +++         GE               
Sbjct: 98  ---EHGNVPLHYACFWGQDQVAEDLVANGALVSI-----CNKYGEMP------------- 136

Query: 496 DAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPS 555
                 +   K P  EL      + G + + +       K  + T+ +         L  
Sbjct: 137 ------VDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPR------NGTLNK 184

Query: 556 HFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILC 615
           H  +   ++ F   +     G+++KGR +   + +K  +   + ++   D F  E   L 
Sbjct: 185 HSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRD-FNEECPRLR 243

Query: 616 QLNHPCVIQFVGACLNDPSQF-AIVTQYISGGSLFSLLHEQKRILDLQSKLI-IAVDVAK 673
             +HP V+  +GAC + P+    ++T ++  GSL+++LHE    +  QS+ +  A+D+A+
Sbjct: 244 IFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMAR 303

Query: 674 GMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNL---R 730
           GM +LH L   I    LNS ++++ ED  A ++           D     + PG +    
Sbjct: 304 GMAFLHTLEPLIPRHALNSRSVMIDEDMTARIS---------MADVKFSFQCPGRMYAPA 354

Query: 731 WMAPEVFTQCTRYTIK--ADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIG 788
           W+APE   +    T +  AD++S+A+ LWE++T E+PFA L        +A   +RP I 
Sbjct: 355 WVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIP 414

Query: 789 YSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEE 822
             I   +  L+    N  P  RP+F  +V  LE+
Sbjct: 415 PGISPHVCKLMKICMNEDPAKRPKFDMIVPILEK 448



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 34/99 (34%), Positives = 59/99 (59%), Gaps = 4/99 (4%)

Query: 293 DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIV 352
           D+N   + G  PLH A  +G   + ++L+  G++  +N  +  D  PLH  +  GH DIV
Sbjct: 26  DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGAR--INVMNRGDDTPLHLAASHGHRDIV 83

Query: 353 KYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII 391
           + LLQ   ++  + VN +G+ PLH AC+ G+ +VA++++
Sbjct: 84  QKLLQYKADI--NAVNEHGNVPLHYACFWGQDQVAEDLV 120



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 41/130 (31%), Positives = 66/130 (50%), Gaps = 4/130 (3%)

Query: 201 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 260
           +GF+ LH A  +  + ++  L+  GA I  +  G  T LH+A   GH +    LLQ+ A+
Sbjct: 33  HGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKAD 92

Query: 261 VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLL 320
           +N  +     PLH A ++G +QV   L+  GA V++  + G+ P+  A A     + +LL
Sbjct: 93  INAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAP----LRELL 148

Query: 321 MEEGSKADVN 330
            E   K   N
Sbjct: 149 RERAEKMGQN 158



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 34/103 (33%), Positives = 55/103 (53%)

Query: 227 DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRL 286
           D+ Q    G + LH A   G     ++L+  GA +N+ +    TPLH+AA +GH  + + 
Sbjct: 26  DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQK 85

Query: 287 LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADV 329
           LL++ AD+N   E G+ PLH A   G   +A+ L+  G+   +
Sbjct: 86  LLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSI 128



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 40/136 (29%), Positives = 65/136 (47%), Gaps = 1/136 (0%)

Query: 160 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 219
           +LN   ++G S LH  C   G+ + +  L+++G R + + R   T LHLA    + +++ 
Sbjct: 26  DLNQGDDHGFSPLHWACR-EGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQ 84

Query: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYG 279
            LL   ADI  V   G   LH A   G  + A+ L+ +GA V+I +     P+  A    
Sbjct: 85  KLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPL 144

Query: 280 HEQVTRLLLKFGADVN 295
            E +     K G ++N
Sbjct: 145 RELLRERAEKMGQNLN 160


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score =  131 bits (330), Expect = 3e-30
 Identities = 116/363 (31%), Positives = 167/363 (46%), Gaps = 26/363 (7%)

Query: 170 SLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQ 229
           S L L C   G    +R L+  G      T    TAL  A    + E+   LL SGA + 
Sbjct: 374 SALTLACY-KGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 432

Query: 230 QVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLK 289
                  + L +A   GH+E A +L++ GAN+   +   +TPL  AA  GHE++  LLL 
Sbjct: 433 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492

Query: 290 FGADVNV-SGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGH 348
            GA++N  + E  +  L LA   GF  +A  L++ G+  ++         PL   S+ GH
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS-----TPLMEASQEGH 547

Query: 349 HDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSET 408
            ++VKYLL S   V  H     GDT L  AC NG  +VA  ++Q      L  E+    T
Sbjct: 548 LELVKYLLASGANV--HATTATGDTALTYACENGHTDVADVLLQAGA--DLEHESEGGRT 603

Query: 409 AFHSACTYGKSIDLVKFLLDQNVININH-QGRDGHTGLHSACYHGHIRLVQFLLDNGADM 467
               A   G  +  V+FL+ +   N+N     + HT +  AC  GH+ +V+ LL +GA  
Sbjct: 604 PLMKAARAG-HLCTVQFLISKGA-NVNRATANNDHTVVSLACAGGHLAVVELLLAHGA-- 659

Query: 468 NLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQ---PGGDG 524
                DP+     KD  T L+ A + GH  +V+ L  Y      +P  + SQ   P  D 
Sbjct: 660 -----DPTHRL--KDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQ 712

Query: 525 SYV 527
           S V
Sbjct: 713 SQV 715



 Score =  111 bits (277), Expect = 4e-24
 Identities = 106/370 (28%), Positives = 168/370 (45%), Gaps = 26/370 (7%)

Query: 156  FSKVNLNYRTE-NGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDN 214
            +  V+++  TE N  + L L C  GG +  +  L+ +  +     + GFT L LA    +
Sbjct: 1042 YPSVDIDAHTESNHDTALTLAC-AGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGH 1100

Query: 215  AELITSLLHSGADIQ-QVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLH 273
              ++  LL  G DI+ Q      T L +A   G  E  D+LL  GAN   ++   +TPL 
Sbjct: 1101 VGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLS 1160

Query: 274  IAAYYGHEQVTRLLLKFGADVN--VSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNA 331
            +AA  G+  + ++LL  GA++N     ++G  PL LA+  G +   KLL++ GS  D+NA
Sbjct: 1161 LAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS--DINA 1218

Query: 332  Q-DNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEI 390
            Q +   +  L      G  ++V  LL     V+       G TPL  A   G  EV + +
Sbjct: 1219 QIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKT--GLTPLMEAASGGYAEVGRVL 1276

Query: 391  IQISGTESLTKENIFSETAFHSACTYGKSIDLVKF--LLDQNVININHQGRDGHTGLHSA 448
            +      +        +TA   A   G      KF  LL     +I+ + + G+T L  A
Sbjct: 1277 LDKGADVNAPPVPSSRDTALTIAADKGH----YKFCELLIHRGAHIDVRNKKGNTPLWLA 1332

Query: 449  CYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVT-LLKHYKR 507
               GH  +VQ L+  GAD++         + +  + T LM A+ KGH  +V  L+K   +
Sbjct: 1333 SNGGHFDVVQLLVQAGADVD---------AADNRKITPLMSAFRKGHVKVVQYLVKEVNQ 1383

Query: 508  PQDELPCNEY 517
               ++ C  Y
Sbjct: 1384 FPSDIECMRY 1393



 Score =  107 bits (267), Expect = 5e-23
 Identities = 92/325 (28%), Positives = 153/325 (47%), Gaps = 18/325 (5%)

Query: 180 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGY-GGLTA 238
           G  + +R L+ +G   +  T  G + L LA      EL   LL   A+++  G  G +T 
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275

Query: 239 LHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSG 298
           L  A+  G+L+   +LL H A+VN Q A   T L  A   G   + ++LL  GA++    
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 299 EVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNE-DHVPLHFCSRFGHHDIVKYLLQ 357
           E G  PL  A++ G + +A++L++ G  A +N   NE     L      GH D+V++LL+
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHG--AGINTHSNEFKESALTLACYKGHLDMVRFLLE 393

Query: 358 SDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYG 417
           +  + +     ++  T L  AC +G  EVA+ ++  SG +     + F      +AC  G
Sbjct: 394 AGADQEHKTDEMH--TALMEACMDGHVEVARLLLD-SGAQVNMPADSFESPLTLAAC--G 448

Query: 418 KSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRS 477
             ++L   L+++   N+     +G+T L  A   GH  +V  LL  GA++N        +
Sbjct: 449 GHVELAALLIERGA-NLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN--------A 499

Query: 478 SGEKDEQTCLMWAYEKGHDAIVTLL 502
             E+ ++T L  A   G   +   L
Sbjct: 500 QTEETQETALTLACCGGFSEVADFL 524



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 78/298 (26%), Positives = 129/298 (43%), Gaps = 28/298 (9%)

Query: 210 VYKDNAELITSLLHSGADIQQVG---YGGLTALHIATIAGHLEAADVLLQHGANVNIQDA 266
           V K  +E+  S    GAD++ V       L AL  A   G L  AD            D 
Sbjct: 117 VLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTAD-------GKAFADP 169

Query: 267 VFFTPLHIAAYYGHEQVTRLLLKFGAD-VNVSGEVGDRPLHLASAKGFLNIAKLLMEEGS 325
                L  +     ++    L +  A+  + +G+V  R L  A + G +N  + L++EG 
Sbjct: 170 EVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGR 229

Query: 326 KADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGD-TPLHLACYNGKF 384
             + + ++ E  + L  CS  G++++ + LL     V+       GD TPL  A   G  
Sbjct: 230 SVNEHTEEGESLLCL-ACSA-GYYELAQVLLAMHANVEDR--GNKGDITPLMAASSGGYL 285

Query: 385 EVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTG 444
           ++ K  + +     +  ++    TA   AC  G  +D+VK LL++   NI     +GHT 
Sbjct: 286 DIVK--LLLLHDADVNSQSATGNTALTYACA-GGFVDIVKVLLNEGA-NIEDHNENGHTP 341

Query: 445 LHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
           L  A   GH+ + + LLD+GA +N        +   + +++ L  A  KGH  +V  L
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGIN--------THSNEFKESALTLACYKGHLDMVRFL 391


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  131 bits (330), Expect = 3e-30
 Identities = 116/363 (31%), Positives = 167/363 (46%), Gaps = 26/363 (7%)

Query: 170 SLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQ 229
           S L L C   G    +R L+  G      T    TAL  A    + E+   LL SGA + 
Sbjct: 374 SALTLACY-KGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 432

Query: 230 QVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLK 289
                  + L +A   GH+E A +L++ GAN+   +   +TPL  AA  GHE++  LLL 
Sbjct: 433 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492

Query: 290 FGADVNV-SGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGH 348
            GA++N  + E  +  L LA   GF  +A  L++ G+  ++         PL   S+ GH
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS-----TPLMEASQEGH 547

Query: 349 HDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSET 408
            ++VKYLL S   V  H     GDT L  AC NG  +VA  ++Q      L  E+    T
Sbjct: 548 LELVKYLLASGANV--HATTATGDTALTYACENGHTDVADVLLQAGA--DLEHESEGGRT 603

Query: 409 AFHSACTYGKSIDLVKFLLDQNVININH-QGRDGHTGLHSACYHGHIRLVQFLLDNGADM 467
               A   G  +  V+FL+ +   N+N     + HT +  AC  GH+ +V+ LL +GA  
Sbjct: 604 PLMKAARAG-HLCTVQFLISKGA-NVNRATANNDHTVVSLACAGGHLAVVELLLAHGA-- 659

Query: 468 NLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQ---PGGDG 524
                DP+     KD  T L+ A + GH  +V+ L  Y      +P  + SQ   P  D 
Sbjct: 660 -----DPTHRL--KDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQ 712

Query: 525 SYV 527
           S V
Sbjct: 713 SQV 715



 Score =  111 bits (277), Expect = 4e-24
 Identities = 106/370 (28%), Positives = 168/370 (45%), Gaps = 26/370 (7%)

Query: 156  FSKVNLNYRTE-NGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDN 214
            +  V+++  TE N  + L L C  GG +  +  L+ +  +     + GFT L LA    +
Sbjct: 1042 YPSVDIDAHTESNHDTALTLAC-AGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGH 1100

Query: 215  AELITSLLHSGADIQ-QVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLH 273
              ++  LL  G DI+ Q      T L +A   G  E  D+LL  GAN   ++   +TPL 
Sbjct: 1101 VGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLS 1160

Query: 274  IAAYYGHEQVTRLLLKFGADVN--VSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNA 331
            +AA  G+  + ++LL  GA++N     ++G  PL LA+  G +   KLL++ GS  D+NA
Sbjct: 1161 LAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS--DINA 1218

Query: 332  Q-DNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEI 390
            Q +   +  L      G  ++V  LL     V+       G TPL  A   G  EV + +
Sbjct: 1219 QIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKT--GLTPLMEAASGGYAEVGRVL 1276

Query: 391  IQISGTESLTKENIFSETAFHSACTYGKSIDLVKF--LLDQNVININHQGRDGHTGLHSA 448
            +      +        +TA   A   G      KF  LL     +I+ + + G+T L  A
Sbjct: 1277 LDKGADVNAPPVPSSRDTALTIAADKGH----YKFCELLIHRGAHIDVRNKKGNTPLWLA 1332

Query: 449  CYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVT-LLKHYKR 507
               GH  +VQ L+  GAD++         + +  + T LM A+ KGH  +V  L+K   +
Sbjct: 1333 SNGGHFDVVQLLVQAGADVD---------AADNRKITPLMSAFRKGHVKVVQYLVKEVNQ 1383

Query: 508  PQDELPCNEY 517
               ++ C  Y
Sbjct: 1384 FPSDIECMRY 1393



 Score =  107 bits (267), Expect = 5e-23
 Identities = 92/325 (28%), Positives = 153/325 (47%), Gaps = 18/325 (5%)

Query: 180 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGY-GGLTA 238
           G  + +R L+ +G   +  T  G + L LA      EL   LL   A+++  G  G +T 
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275

Query: 239 LHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSG 298
           L  A+  G+L+   +LL H A+VN Q A   T L  A   G   + ++LL  GA++    
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335

Query: 299 EVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNE-DHVPLHFCSRFGHHDIVKYLLQ 357
           E G  PL  A++ G + +A++L++ G  A +N   NE     L      GH D+V++LL+
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHG--AGINTHSNEFKESALTLACYKGHLDMVRFLLE 393

Query: 358 SDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYG 417
           +  + +     ++  T L  AC +G  EVA+ ++  SG +     + F      +AC  G
Sbjct: 394 AGADQEHKTDEMH--TALMEACMDGHVEVARLLLD-SGAQVNMPADSFESPLTLAAC--G 448

Query: 418 KSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRS 477
             ++L   L+++   N+     +G+T L  A   GH  +V  LL  GA++N        +
Sbjct: 449 GHVELAALLIERGA-NLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN--------A 499

Query: 478 SGEKDEQTCLMWAYEKGHDAIVTLL 502
             E+ ++T L  A   G   +   L
Sbjct: 500 QTEETQETALTLACCGGFSEVADFL 524



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 78/298 (26%), Positives = 129/298 (43%), Gaps = 28/298 (9%)

Query: 210 VYKDNAELITSLLHSGADIQQVG---YGGLTALHIATIAGHLEAADVLLQHGANVNIQDA 266
           V K  +E+  S    GAD++ V       L AL  A   G L  AD            D 
Sbjct: 117 VLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTAD-------GKAFADP 169

Query: 267 VFFTPLHIAAYYGHEQVTRLLLKFGAD-VNVSGEVGDRPLHLASAKGFLNIAKLLMEEGS 325
                L  +     ++    L +  A+  + +G+V  R L  A + G +N  + L++EG 
Sbjct: 170 EVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGR 229

Query: 326 KADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGD-TPLHLACYNGKF 384
             + + ++ E  + L  CS  G++++ + LL     V+       GD TPL  A   G  
Sbjct: 230 SVNEHTEEGESLLCL-ACSA-GYYELAQVLLAMHANVEDR--GNKGDITPLMAASSGGYL 285

Query: 385 EVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTG 444
           ++ K  + +     +  ++    TA   AC  G  +D+VK LL++   NI     +GHT 
Sbjct: 286 DIVK--LLLLHDADVNSQSATGNTALTYACA-GGFVDIVKVLLNEGA-NIEDHNENGHTP 341

Query: 445 LHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 502
           L  A   GH+ + + LLD+GA +N        +   + +++ L  A  KGH  +V  L
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGIN--------THSNEFKESALTLACYKGHLDMVRFL 391


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,459,407
Number of Sequences: 37866
Number of extensions: 1704838
Number of successful extensions: 11953
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 719
Number of HSP's successfully gapped in prelim test: 401
Number of HSP's that attempted gapping in prelim test: 4335
Number of HSP's gapped (non-prelim): 3208
length of query: 936
length of database: 18,247,518
effective HSP length: 112
effective length of query: 824
effective length of database: 14,006,526
effective search space: 11541377424
effective search space used: 11541377424
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.