Search of human proteins with 163644316

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|163644316 hypothetical protein LOC23255 [Homo sapiens]
         (1586 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|163644316 hypothetical protein LOC23255 [Homo sapiens]            3197   0.0  
gi|66773344 hypothetical protein LOC140710 [Homo sapiens]             601   e-171
gi|59806361 hypothetical protein LOC387104 [Homo sapiens]             570   e-162
gi|239756018 PREDICTED: similar to hCG1790963 [Homo sapiens]          133   2e-30
gi|239750538 PREDICTED: hypothetical protein XP_002347438 [Homo ...   133   2e-30
gi|239744837 PREDICTED: hypothetical protein XP_002343283 [Homo ...   130   8e-30
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     79   3e-14
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             75   7e-13
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        73   2e-12
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        73   2e-12
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         73   2e-12
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         73   2e-12
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         73   2e-12
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         73   2e-12
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         73   2e-12
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         73   2e-12
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         64   1e-09
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    64   1e-09
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    64   1e-09
gi|22749429 coiled-coil domain containing 89 [Homo sapiens]            63   3e-09
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           62   4e-09
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           62   4e-09
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           62   4e-09
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                62   4e-09
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    62   4e-09
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    62   4e-09
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    62   4e-09
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    62   4e-09
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...    62   6e-09
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    61   1e-08

>gi|163644316 hypothetical protein LOC23255 [Homo sapiens]
          Length = 1586

 Score = 3197 bits (8288), Expect = 0.0
 Identities = 1586/1586 (100%), Positives = 1586/1586 (100%)

Query: 1    MEEMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRS 60
            MEEMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRS
Sbjct: 1    MEEMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRS 60

Query: 61   LEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKES 120
            LEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKES
Sbjct: 61   LEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKES 120

Query: 121  SLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKY 180
            SLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKY
Sbjct: 121  SLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKY 180

Query: 181  KSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEME 240
            KSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEME
Sbjct: 181  KSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEME 240

Query: 241  DMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNR 300
            DMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNR
Sbjct: 241  DMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNR 300

Query: 301  QLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENH 360
            QLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENH
Sbjct: 301  QLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENH 360

Query: 361  ALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEE 420
            ALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEE
Sbjct: 361  ALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEE 420

Query: 421  MFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLH 480
            MFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLH
Sbjct: 421  MFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLH 480

Query: 481  DAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGL 540
            DAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGL
Sbjct: 481  DAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGL 540

Query: 541  SPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLR 600
            SPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLR
Sbjct: 541  SPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLR 600

Query: 601  LRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEE 660
            LRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEE
Sbjct: 601  LRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEE 660

Query: 661  TETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQQELRSLKQNIFL 720
            TETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQQELRSLKQNIFL
Sbjct: 661  TETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQQELRSLKQNIFL 720

Query: 721  FYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCG 780
            FYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCG
Sbjct: 721  FYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCG 780

Query: 781  FPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFSAFKALLEDFRAELREDERA 840
            FPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFSAFKALLEDFRAELREDERA
Sbjct: 781  FPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFSAFKALLEDFRAELREDERA 840

Query: 841  RLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELGSSAESKGALKKEREVHQKL 900
            RLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELGSSAESKGALKKEREVHQKL
Sbjct: 841  RLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELGSSAESKGALKKEREVHQKL 900

Query: 901  LADSHSLVMDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQKENSP 960
            LADSHSLVMDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQKENSP
Sbjct: 901  LADSHSLVMDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQKENSP 960

Query: 961  RRGGSFLCDQKDGNVRPFPHQGSLRMPRPVAMWPCADADSIPFEDRPLSKLKESDRCSAS 1020
            RRGGSFLCDQKDGNVRPFPHQGSLRMPRPVAMWPCADADSIPFEDRPLSKLKESDRCSAS
Sbjct: 961  RRGGSFLCDQKDGNVRPFPHQGSLRMPRPVAMWPCADADSIPFEDRPLSKLKESDRCSAS 1020

Query: 1021 ENLYLDALSLDDEPEEPPAHRPEREFRNRLPEEEENHKGNLQRAVSVSSMSEFQRLMDIS 1080
            ENLYLDALSLDDEPEEPPAHRPEREFRNRLPEEEENHKGNLQRAVSVSSMSEFQRLMDIS
Sbjct: 1021 ENLYLDALSLDDEPEEPPAHRPEREFRNRLPEEEENHKGNLQRAVSVSSMSEFQRLMDIS 1080

Query: 1081 PFLPEKGLPSTSSKEDVTPPLSPDDLKYIEEFNKSWDYTPNRGHNGGGPDLWADRTEVGR 1140
            PFLPEKGLPSTSSKEDVTPPLSPDDLKYIEEFNKSWDYTPNRGHNGGGPDLWADRTEVGR
Sbjct: 1081 PFLPEKGLPSTSSKEDVTPPLSPDDLKYIEEFNKSWDYTPNRGHNGGGPDLWADRTEVGR 1140

Query: 1141 AGHEDSTEPFPDSSWYLTTSVTMTTDTMTSPEHCQKQPLRSHVLTEQSGLRVLHSPPAVR 1200
            AGHEDSTEPFPDSSWYLTTSVTMTTDTMTSPEHCQKQPLRSHVLTEQSGLRVLHSPPAVR
Sbjct: 1141 AGHEDSTEPFPDSSWYLTTSVTMTTDTMTSPEHCQKQPLRSHVLTEQSGLRVLHSPPAVR 1200

Query: 1201 RVDSITAAGGEGPFPTSRARGSPGDTKGGPPEPMLSRWPCTSPRHSRDYVEGARRPLDSP 1260
            RVDSITAAGGEGPFPTSRARGSPGDTKGGPPEPMLSRWPCTSPRHSRDYVEGARRPLDSP
Sbjct: 1201 RVDSITAAGGEGPFPTSRARGSPGDTKGGPPEPMLSRWPCTSPRHSRDYVEGARRPLDSP 1260

Query: 1261 LCTSLGFASPLHSLEMSKNLSDDMKEVAFSVRNAICSGPGELQVKDMACQTNGSRTMGTQ 1320
            LCTSLGFASPLHSLEMSKNLSDDMKEVAFSVRNAICSGPGELQVKDMACQTNGSRTMGTQ
Sbjct: 1261 LCTSLGFASPLHSLEMSKNLSDDMKEVAFSVRNAICSGPGELQVKDMACQTNGSRTMGTQ 1320

Query: 1321 TVQTISVGLQTEALRGSGVTSSPHKCLTPKAGGGATPVSSPSRSLRSRQVAPAIEKVQAK 1380
            TVQTISVGLQTEALRGSGVTSSPHKCLTPKAGGGATPVSSPSRSLRSRQVAPAIEKVQAK
Sbjct: 1321 TVQTISVGLQTEALRGSGVTSSPHKCLTPKAGGGATPVSSPSRSLRSRQVAPAIEKVQAK 1380

Query: 1381 FERTCCSPKYGSPKLQRKPLPKADQPNNRTSPGMAQKGYSESAWARSTTTRESPVHTTIN 1440
            FERTCCSPKYGSPKLQRKPLPKADQPNNRTSPGMAQKGYSESAWARSTTTRESPVHTTIN
Sbjct: 1381 FERTCCSPKYGSPKLQRKPLPKADQPNNRTSPGMAQKGYSESAWARSTTTRESPVHTTIN 1440

Query: 1441 DGLSSLFNIIDHSPVVQDPFQKGLRAGSRSRSAEPRPELGPGQETGTNSRGRSPSPIGVG 1500
            DGLSSLFNIIDHSPVVQDPFQKGLRAGSRSRSAEPRPELGPGQETGTNSRGRSPSPIGVG
Sbjct: 1441 DGLSSLFNIIDHSPVVQDPFQKGLRAGSRSRSAEPRPELGPGQETGTNSRGRSPSPIGVG 1500

Query: 1501 SEMCREEGGEGTPVKQDLSAPPGYTLTENVARILNKKLLEHALKEERRQAAHGPPGLHSD 1560
            SEMCREEGGEGTPVKQDLSAPPGYTLTENVARILNKKLLEHALKEERRQAAHGPPGLHSD
Sbjct: 1501 SEMCREEGGEGTPVKQDLSAPPGYTLTENVARILNKKLLEHALKEERRQAAHGPPGLHSD 1560

Query: 1561 SHSLGDTAEPGPMENQTVLLTAPWGL 1586
            SHSLGDTAEPGPMENQTVLLTAPWGL
Sbjct: 1561 SHSLGDTAEPGPMENQTVLLTAPWGL 1586


>gi|66773344 hypothetical protein LOC140710 [Homo sapiens]
          Length = 1016

 Score =  601 bits (1549), Expect = e-171
 Identities = 394/973 (40%), Positives = 553/973 (56%), Gaps = 104/973 (10%)

Query: 1   MEEMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRS 60
           M EMRD Y+EEDVYQLQELR++LD+A+K CRILQYRLRKAE++SL+ A+TGQVDGELIR 
Sbjct: 1   MLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRG 60

Query: 61  LEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKES 120
           LEQD+KV+KD+S+RLH EL+ VE+KRA+ E+ENE LRQ++IE E++KQ LQ ELER +E 
Sbjct: 61  LEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREH 120

Query: 121 SLKRRSTREMYK-EKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQK 179
           SLK+R TR + K +KKT  Q+DSADL+CQL FAKEE+ LM KK+ KL +E D +++EL K
Sbjct: 121 SLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLK 180

Query: 180 YKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEM 239
           Y+SLYGD+DS L   E    P +RE ELK+ LKLVEEEAN+L R+IVELEVENRGL+AEM
Sbjct: 181 YRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEM 240

Query: 240 EDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHN 299
           +DM+      G G +   +      G+  ES  ELRRHLQFVEEEAELLRRS +E+ED N
Sbjct: 241 DDMKDHGGGCG-GPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQN 299

Query: 300 RQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHEN 359
           + L +EL+KF+ E   +     +  S  +    P QEEL +A+LQI ELSGKV KLQ+EN
Sbjct: 300 KLLLNELAKFRSEHELDVALSEDSCSVLS---EPSQEELAAAKLQIGELSGKVKKLQYEN 356

Query: 360 HALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSE 419
             LLSN+QRCDLA+    R     D++A   A           +P P             
Sbjct: 357 RVLLSNLQRCDLASCQSTRPMLETDAEAGDSA---------QCVPAPL------------ 395

Query: 420 EMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFL 479
                          E  E     L +ARE +E L  L+ +A  + + ++ L+ D + F 
Sbjct: 396 --------------GETHESHAVRLCRARE-AEVLPGLREQAALVSKAIDVLVADANGFT 440

Query: 480 HDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDG 539
               L          L    +  EG  ++ +L+  I  ++   ++EL AF  + + +  G
Sbjct: 441 AGLRLCLDNECADFRLHEAPDNSEG-PRDTKLIHAILVRLSVLQQELNAFTRKADAV-LG 498

Query: 540 LSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQ-----------SRLKEQLEWQL 588
            S +    ES S L  + S      I  L K+LG D Q            R++E      
Sbjct: 499 CS-VKEQQESFSSLPPLGSQGLSKEI-LLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGD 556

Query: 589 GPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQG 648
             ++ D   S R       +R  D D+ +  +       L+L    VL E   S+  LQ 
Sbjct: 557 LDSKPDPSRSFR------PYRAEDNDSYASEIK-----ELQL----VLAEAHDSLRGLQE 601

Query: 649 QLVQAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQ 708
           QL Q  +L +EE + F  K+ +++E+   AL  +E E+ SL+LQ  L ++ WS EKN++ 
Sbjct: 602 QLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLV 661

Query: 709 QELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQA 768
           QE +  K N  L ++KLRW LK WRQGK +  EG++F E      ++ + EL +    + 
Sbjct: 662 QESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLE------VNSMKELYLLMEEEE 715

Query: 769 DGPDHDSDRGC-GFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFSAFKALL 827
               H  ++ C G    +++P+  +                         +  +  K  L
Sbjct: 716 INAQHSDNKACTGDSWTQNTPNEYI-------------------------KTLADMKVTL 750

Query: 828 EDFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELGSSAESK 887
           ++    LR++ R    LQQQ+A  KA W+ E A LK    Q+E KT    GE  +  + K
Sbjct: 751 KELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGE-RAGPDWK 809

Query: 888 GALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEF 947
            AL++ERE  Q LLA+S+S VM+L  Q+  SE+NW++EK++L++RL  ++Q+ E+Q KE 
Sbjct: 810 AALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKEL 869

Query: 948 LWRIEQLQKENSP 960
             R+ QLQK   P
Sbjct: 870 QNRLSQLQKAADP 882


>gi|59806361 hypothetical protein LOC387104 [Homo sapiens]
          Length = 947

 Score =  570 bits (1469), Expect = e-162
 Identities = 313/539 (58%), Positives = 400/539 (74%), Gaps = 29/539 (5%)

Query: 1   MEEMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRS 60
           M+EMRD++ EED  QLQE+R EL+RANKNCRILQYRLRKAE+K L+ A+TG++DGEL+RS
Sbjct: 377 MDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRS 436

Query: 61  LEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKES 120
           LEQDLKVAKDVSVRLHHEL+ VEEKR   EDENE LRQQ+IEVEI+KQALQNELE++KE 
Sbjct: 437 LEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKEL 496

Query: 121 SLKRRSTREMYKEKK----TFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQE 176
           SLKRR ++++ K +K    T  ++D+ DL+CQLQF KEEA LMRKKMAK+ +EKD  E E
Sbjct: 497 SLKRRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHE 556

Query: 177 LQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLK 236
           LQKY+S YGD+DSPLP GEAGGPPSTREAELKLRL+LVEEEANILGRKIVELEVENRGLK
Sbjct: 557 LQKYRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLK 616

Query: 237 AEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIE 296
           AE++D+RG         D           +  ES +ELR+HLQ VE+E ELLRR+++++E
Sbjct: 617 AELDDLRG---------DDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLE 667

Query: 297 DHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQ 356
           + N+++T EL+K+K+    + G               LQEELK+ARLQI+ELSGKV++LQ
Sbjct: 668 EQNKRITAELNKYKY----KSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQ 723

Query: 357 HENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGES 416
           +EN  L+SN+QR DLA+HLG+R  SPRDSDAESDAGKKESD ++SR P  KREGP+GGES
Sbjct: 724 YENRVLMSNMQRYDLASHLGIRG-SPRDSDAESDAGKKESD-DDSRPPHRKREGPIGGES 781

Query: 417 DSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTD 476
           DSEE+           P+ +  P P    K+  D + +  ++ EA+RL +T++RLI DT 
Sbjct: 782 DSEEV----RNIRCLTPTRSFYPAPGPWPKSFSDRQQMKDIRSEAERLGKTIDRLIADTS 837

Query: 477 SFLHDAGL--RGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQV 533
           + + +A +    G      GL  EE+ G    +E +LL  INA+MKAF+KELQ F++++
Sbjct: 838 TIITEARIYVANGDLF---GLMDEEDDG-SRIREHELLYRINAQMKAFRKELQTFIDRL 892



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 70/300 (23%), Positives = 136/300 (45%), Gaps = 39/300 (13%)

Query: 78  ELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTF 137
           E + ++E+  K  +ENETL+              NE++ L+          EM + + TF
Sbjct: 348 EQEEMQEEMEKLREENETLK--------------NEIDELR---------TEMDEMRDTF 384

Query: 138 NQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAG 197
            ++D+    CQLQ  + E     K    L     + E++  +Y    G++D  L      
Sbjct: 385 FEEDA----CQLQEMRHELERANKNCRILQYRLRKAERKRLRYAQT-GEIDGELLRSLEQ 439

Query: 198 GPPSTREAELKLRLKL---------VEEEANILGRKIVELEVENRGLKAEMEDMRGQQER 248
                ++  ++L  +L          E+E   L ++++E+E+  + L+ E+E M+    +
Sbjct: 440 DLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLK 499

Query: 249 EGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSK 308
               +D   S   +    + E + +L+  LQFV+EEA L+R+ +++I+    +  HEL K
Sbjct: 500 RRGSKDLPKSEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQK 559

Query: 309 FK--FEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNI 366
           ++  +     P   GE   P +   A L+  L+    + + L  K+++L+ EN  L + +
Sbjct: 560 YRSFYGDLDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAEL 619


>gi|239756018 PREDICTED: similar to hCG1790963 [Homo sapiens]
          Length = 196

 Score =  133 bits (334), Expect = 2e-30
 Identities = 63/72 (87%), Positives = 66/72 (91%)

Query: 1503 MCREEGGEGTPVKQDLSAPPGYTLTENVARILNKKLLEHALKEERRQAAHGPPGLHSDSH 1562
            MCREEGGEGTP +QDL AP GYTLTENVARILN+KLLEHA+KEERRQAAHGPPG HSDSH
Sbjct: 1    MCREEGGEGTPARQDLPAPRGYTLTENVARILNRKLLEHAVKEERRQAAHGPPGPHSDSH 60

Query: 1563 SLGDTAEPGPME 1574
            SL DTAEPG ME
Sbjct: 61   SLRDTAEPGAME 72


>gi|239750538 PREDICTED: hypothetical protein XP_002347438 [Homo
            sapiens]
          Length = 196

 Score =  133 bits (334), Expect = 2e-30
 Identities = 63/72 (87%), Positives = 66/72 (91%)

Query: 1503 MCREEGGEGTPVKQDLSAPPGYTLTENVARILNKKLLEHALKEERRQAAHGPPGLHSDSH 1562
            MCREEGGEGTP +QDL AP GYTLTENVARILN+KLLEHA+KEERRQAAHGPPG HSDSH
Sbjct: 1    MCREEGGEGTPARQDLPAPRGYTLTENVARILNRKLLEHAVKEERRQAAHGPPGPHSDSH 60

Query: 1563 SLGDTAEPGPME 1574
            SL DTAEPG ME
Sbjct: 61   SLRDTAEPGAME 72


>gi|239744837 PREDICTED: hypothetical protein XP_002343283 [Homo
            sapiens]
          Length = 196

 Score =  130 bits (328), Expect = 8e-30
 Identities = 62/72 (86%), Positives = 66/72 (91%)

Query: 1503 MCREEGGEGTPVKQDLSAPPGYTLTENVARILNKKLLEHALKEERRQAAHGPPGLHSDSH 1562
            MCREEGGEGTP +QDL AP GYTLTENVARILN+KLLE+A+KEERRQAAHGPPG HSDSH
Sbjct: 1    MCREEGGEGTPARQDLPAPRGYTLTENVARILNRKLLEYAVKEERRQAAHGPPGPHSDSH 60

Query: 1563 SLGDTAEPGPME 1574
            SL DTAEPG ME
Sbjct: 61   SLRDTAEPGAME 72


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 195/997 (19%), Positives = 384/997 (38%), Gaps = 121/997 (12%)

Query: 9    LEEDVYQLQELRRELDRANK--NCRILQY--RLRKAEQKSLKVAETGQVDGELIRSLEQD 64
            LEE+   L++   +L +  K    RI ++   L + E+KS  +A+       +I  LE+ 
Sbjct: 976  LEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEER 1035

Query: 65   LKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKR 124
            L+       R   + + +E+ R K E ++  L  Q+ E++     L+ +L + +E     
Sbjct: 1036 LR-------REEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAA 1088

Query: 125  RSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLY 184
             +  E    +K        +L  Q+   +E+    R    K  ++K +L +EL+  K+  
Sbjct: 1089 LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL 1148

Query: 185  GD-VDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMR 243
             D +DS     E     S RE E+ +  K +EEEA     +I E+  ++     E+ +  
Sbjct: 1149 EDTLDSTAAQQELR---SKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQL 1205

Query: 244  GQQEREGPGRDHAPSIPTSPFGDS-------LESSTELRRHLQFVEEEAELLRRSISEIE 296
             Q +R     + A     +  G+        L+   +     + VE + + L+   +E E
Sbjct: 1206 EQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGE 1265

Query: 297  DHNRQLTHELSKFKFEPPREPGWLGEGASPGA----------GGGAPLQEELKSARLQIS 346
                +L  +++K + E     G L +  S  +                QE L+    Q  
Sbjct: 1266 RVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKL 1325

Query: 347  ELSGKVLKLQHENHALLSNIQRCDLAAH-LGLRAPSPRDSDAESDAGKKESDGEESRLPQ 405
             LS K+ +++ E ++    ++  + A H L  +  +     A+     ++S G      +
Sbjct: 1326 SLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385

Query: 406  PKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQ--- 462
             KR+     E  S+   EK + +      +  E   T L +  +D   LV L H+ Q   
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAY------DKLEKTKTRLQQELDD--LLVDLDHQRQSAC 1437

Query: 463  ---RLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKM 519
               + ++  ++L+ +  +                    E ++ E + +E +      A+ 
Sbjct: 1438 NLEKKQKKFDQLLAEEKTI-------------SAKYAEERDRAEAEAREKETKALSLARA 1484

Query: 520  KAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSR 579
                 E +A LE++N+           TE    +S+   V +        K         
Sbjct: 1485 LEEAMEQKAELERLNK--------QFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEE 1536

Query: 580  LKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLP-- 637
            +K QLE      +  E   LRL    E++ +A        L G+   S E +   V    
Sbjct: 1537 MKTQLEELEDELQATEDAKLRL----EVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVR 1592

Query: 638  --EQSVSIEELQGQLVQAARLHQE----ETETFTNKIHKMEEEHLYALRWKELEMHSLAL 691
              E  +  E  Q  +  AAR   E    + E   +  +K  +E +  LR  + +M     
Sbjct: 1593 EMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR 1652

Query: 692  QNTLHERTWSDEKNLMQ-----QELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEE-GEEF 745
            +  L +   S E+ L Q     ++L+S++  +     +L    +  RQ +Q  +E  +E 
Sbjct: 1653 E--LDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1710

Query: 746  TEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTAD 805
                    L+   +  ++        + + ++G    + +    + +QI   +  L   +
Sbjct: 1711 ANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNL-E 1769

Query: 806  RGQPHKQVVENQQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCR 865
            R    K     QQL               R+++  +++LQ+   + K+ +      L+ +
Sbjct: 1770 RSHAQKNENARQQLE--------------RQNKELKVKLQEMEGTVKSKYKASITALEAK 1815

Query: 866  LEQLEEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNRE 925
            + QLEE+ +N+      + E + A K+ R   +KL         D+  Q+    +N  + 
Sbjct: 1816 IAQLEEQLDNE------TKERQAACKQVRRTEKKL--------KDVLLQVDDERRNAEQY 1861

Query: 926  KVELLDRLDRDRQEWERQKKEFLWRIEQLQKENSPRR 962
            K    D+ D+     ++ K++     E+ Q+ N+ RR
Sbjct: 1862 K----DQADKASTRLKQLKRQLEEAEEEAQRANASRR 1894



 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 206/991 (20%), Positives = 372/991 (37%), Gaps = 140/991 (14%)

Query: 15   QLQELRRELDRANKN----CRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKD 70
            + +ELR  L    +     C  L+ R+ + E++   +    +   + I+ LE+ L+  + 
Sbjct: 898  EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEES 957

Query: 71   VSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRSTREM 130
               +L  E  T E K  K E+E   L  Q  ++   K+ L++ +     +  +     + 
Sbjct: 958  ARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKS 1017

Query: 131  YKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSP 190
              + K  ++    DL  +L+  +++   + K   KL  +  +L  ++ + ++   ++   
Sbjct: 1018 LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQ 1077

Query: 191  LPTGEAGGPPSTREAELKLRLKLVEEEA---NILGRKIVELEVENRGLKAEMEDMRGQQE 247
            L         + +E EL+  L  VEEEA   N+  +KI ELE +   L+ ++E  R  + 
Sbjct: 1078 L---------AKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRN 1128

Query: 248  R-EGPGRDHAPSIPT--SPFGDSLESST---ELRRHLQ--------FVEEEAELLRRSIS 293
            + E   RD    +    +   D+L+S+    ELR   +         +EEEA+     I 
Sbjct: 1129 KAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188

Query: 294  EIEDHNRQLTHELS--------------KFKFEPPREPGWLGEGASPGAGGGAPLQEELK 339
            E+   + Q   EL+              K K     E G L         G    + + K
Sbjct: 1189 EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRK 1248

Query: 340  SARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGE 399
                Q+ EL  K  + +     L   + +  L   L         SD++S    K+    
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTK--LQVELDNVTGLLSQSDSKSSKLTKDFSAL 1306

Query: 400  ESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKH 459
            ES+L   +       E   EE  +K S     K  E  +    E L+  E++      KH
Sbjct: 1307 ESQLQDTQ-------ELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEA------KH 1353

Query: 460  EAQRLERTVERLITDTDSFLHDA-GLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAK 518
              ++   T+   + D    + D+ G    A      LQ   +  EG  Q  +       K
Sbjct: 1354 NLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ---KDLEGLSQRHEEKVAAYDK 1410

Query: 519  MKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQS 578
            ++  K  LQ  L+      D L  L H  +S+  L        +       + L  +   
Sbjct: 1411 LEKTKTRLQQELD------DLLVDLDHQRQSACNL--------EKKQKKFDQLLAEEKTI 1456

Query: 579  RLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPE 638
              K   E     A   E+E+  L  AR L    +       L  Q  F  E+     L  
Sbjct: 1457 SAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQ--FRTEMED---LMS 1511

Query: 639  QSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHER 698
                + +   +L ++ R  +++ E    ++ ++E+E       +  E   L L+  L   
Sbjct: 1512 SKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDE------LQATEDAKLRLEVNLQAM 1565

Query: 699  TWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLG 758
                E++L  ++ +S ++   L            RQ ++ME E E+  +       +R  
Sbjct: 1566 KAQFERDLQGRDEQSEEKKKQLV-----------RQVREMEAELEDERKQRSMAVAARKK 1614

Query: 759  -ELGVQG-GHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQ--TADRGQPHKQVV 814
             E+ ++      D  + + D        +     + Q+ D    L    A R +   Q  
Sbjct: 1615 LEMDLKDLEAHIDSANKNRDEAI-----KQLRKLQAQMKDCMRELDDTRASREEILAQAK 1669

Query: 815  ENQQLFSAFKALLEDFRAELREDERARLRLQQQ---------YASDKAAWDV-EWAVLKC 864
            EN++   + +A +   + EL   ERA+ + QQ+          +S K A  + E   L+ 
Sbjct: 1670 ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEA 1729

Query: 865  RLEQLEEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNR 924
            R+ QLEE+ E    E G++      LKK              +  DL  +  H++KN N 
Sbjct: 1730 RIAQLEEELEE---EQGNTELINDRLKKAN-------LQIDQINTDLNLERSHAQKNENA 1779

Query: 925  EKVELLDRLDRDRQEWERQKKEFLWRIEQLQ 955
                        RQ+ ERQ KE   ++++++
Sbjct: 1780 ------------RQQLERQNKELKVKLQEME 1798



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 76/365 (20%), Positives = 151/365 (41%), Gaps = 46/365 (12%)

Query: 10   EEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQ---DLK 66
            EE++ +++E +   +        LQ +L     + L++ E  Q + EL    E+    L 
Sbjct: 851  EEELVKVREKQLAAENRLTEMETLQSQLMA---EKLQLQEQLQAETELCAEAEELRARLT 907

Query: 67   VAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRS 126
              K     + H+L+      A+ E+E E  R Q ++ E  K+ +Q  ++ L+E   +  S
Sbjct: 908  AKKQELEEICHDLE------ARVEEEEE--RCQHLQAE--KKKMQQNIQELEEQLEEEES 957

Query: 127  TREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKY-KSLYG 185
             R+  + +K   +        +L+  +EE  ++  +  KL +EK  LE  + ++  +L  
Sbjct: 958  ARQKLQLEKVTTE-------AKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTE 1010

Query: 186  DVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQ 245
            + +      +          +L+ RL+  E++   L +   +LE ++  L  ++ +++ Q
Sbjct: 1011 EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ 1070

Query: 246  ----------QEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEI 295
                      +E E            +    +L+   EL   +  ++E+ E  R S ++ 
Sbjct: 1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKA 1130

Query: 296  EDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKL 355
            E   R L  EL   K E       L +     A      Q+EL+S R Q   +  K L+ 
Sbjct: 1131 EKQKRDLGEELEALKTE-------LEDTLDSTAA-----QQELRSKREQEVNILKKTLEE 1178

Query: 356  QHENH 360
            + + H
Sbjct: 1179 EAKTH 1183



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 78/412 (18%), Positives = 155/412 (37%), Gaps = 77/412 (18%)

Query: 74   RLHHELKTVEEKRAKAEDENETLRQQMIEVE-------ISKQALQNELERLKESSLKRRS 126
            R   E+   EE+  K  ++      ++ E+E         K  LQ +L+   E   +   
Sbjct: 842  RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEE 901

Query: 127  TREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGD 186
             R     KK   ++   DL  +++  +E    ++ +  K+ +   ELE++L++ +S    
Sbjct: 902  LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK 961

Query: 187  VDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQ 246
            +     T EA             +LK +EEE  IL  +  +L  E + L+  + +     
Sbjct: 962  LQLEKVTTEA-------------KLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEF---- 1004

Query: 247  EREGPGRDHAPSIPTSPFGDSLESSTEL----RRHLQFVEEEAELLRRSISEIEDHNRQL 302
                          T+   +  E S  L     +H   + +  E LRR     E+  RQ 
Sbjct: 1005 --------------TTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRR-----EEKQRQ- 1044

Query: 303  THELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHAL 362
              E ++ K E                G    L +++   + QI+EL  ++ K + E  A 
Sbjct: 1045 ELEKTRRKLE----------------GDSTDLSDQIAELQAQIAELKMQLAKKEEELQAA 1088

Query: 363  LSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMF 422
            L+ ++      ++ L+    +  + ES   + + D E  R  + K       E    ++ 
Sbjct: 1089 LARVEEEAAQKNMALK----KIRELESQISELQEDLESERASRNK------AEKQKRDLG 1138

Query: 423  EKTSGFGSGKPSEASEPCPTELLKAREDSEYLV---TLKHEAQRLERTVERL 471
            E+     +            + L+++ + E  +   TL+ EA+  E  ++ +
Sbjct: 1139 EELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEM 1190



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 51/191 (26%), Positives = 82/191 (42%), Gaps = 28/191 (14%)

Query: 1    MEEMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRS 60
            +EE R   LE  + QL+E   EL+    N  ++  RL+KA  +  ++      D  L RS
Sbjct: 1721 LEEKRR--LEARIAQLEE---ELEEEQGNTELINDRLKKANLQIDQI----NTDLNLERS 1771

Query: 61   LEQDLKVAKDVSVRLHHELK--------TVEEK--------RAKAEDENETLRQQMIEVE 104
              Q  + A+    R + ELK        TV+ K         AK     E L  +  E +
Sbjct: 1772 HAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQ 1831

Query: 105  ISKQALQNELERLKESSLK---RRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRK 161
             + + ++   ++LK+  L+    R   E YK++          L+ QL+ A+EEA     
Sbjct: 1832 AACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANA 1891

Query: 162  KMAKLGREKDE 172
               KL RE ++
Sbjct: 1892 SRRKLQRELED 1902


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 74.7 bits (182), Expect = 7e-13
 Identities = 181/1014 (17%), Positives = 389/1014 (38%), Gaps = 157/1014 (15%)

Query: 3    EMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLE 62
            ++ + + EE V + + ++  L + + +C+ LQ RL  +E    ++       GE  + L+
Sbjct: 320  KLEEKHNEESVSK-KNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLK 378

Query: 63   QDLKVAKDVSVRLHHELKTVEEKRAKAED-------ENETLRQQMIEVE----------- 104
            ++L   +     L  E K ++++R + E        E   L  +++E E           
Sbjct: 379  EELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLK 438

Query: 105  ----ISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMR 160
                +S + L ++ +++ +  LK     E  KEK T + +    L    Q  +E+  L +
Sbjct: 439  EQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQ 498

Query: 161  KKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANI 220
               AKL   +++LEQ L++     GD D  +   EA    S      K  + L+E+E   
Sbjct: 499  STTAKLREAQNDLEQVLRQ----IGDKDQKIQNLEALLQKS------KENISLLEKERED 548

Query: 221  LGRKIV----------ELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLES 270
            L  KI           +L+ +N  L+ ++  +  + + +      A         +  + 
Sbjct: 549  LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE-------NLHDQ 601

Query: 271  STELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGG 330
              E + HL+  ++    L  S++E+     +   ++S+   +   +   L    +     
Sbjct: 602  VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ 661

Query: 331  GAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQ----RC-DLAAHL-----GLRAP 380
             A LQ  L +A+  + +   ++ K+  +   + + +Q     C  L +HL        + 
Sbjct: 662  RADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL 721

Query: 381  SPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPC 440
              +  + E    K E+D  E +  + +    +  +       E  +   S +     E  
Sbjct: 722  EQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV 781

Query: 441  PTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEE 500
             +  L  ++ SE L ++K +  + E   + L  D ++   +  ++             EE
Sbjct: 782  SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQ------------HEE 829

Query: 501  QGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVS 560
                 Q     L  +  + +A   EL    ++++++ D L       E  +       + 
Sbjct: 830  LNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILD 889

Query: 561  RDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGL 620
             +     L  +L   +++ LKEQ E               L+ + E  + A     SH L
Sbjct: 890  LEKTCKELKHQLQVQMENTLKEQKE---------------LKKSLEKEKEA-----SHQL 929

Query: 621  GGQTCFSLELRGPPVLPEQSVSIEELQGQLVQA---ARLHQEETETFTNKIHKMEEEHLY 677
                                + +  +Q QL+QA    + +++E +     I+++++    
Sbjct: 930  -------------------KLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSS-- 968

Query: 678  ALRWKELEMHSLALQNTLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQ 737
              + K++E     L+  + ++T  + +N +QQ+L    Q +     K+  L  ++ + ++
Sbjct: 969  EQKKKQIEALQGELKIAVLQKT--ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQE 1026

Query: 738  MEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDH 797
              ++ +    G   E L+   +L                          S   ++ +   
Sbjct: 1027 TFKQLQSDFYGRESELLATRQDL-------------------------KSVEEKLSLAQE 1061

Query: 798  SLRLQTADRGQPHKQVVENQQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDV 857
             L       G  +K +   Q+L +A KA LE   A+  +  + R +  Q    +K+  + 
Sbjct: 1062 DLISNRNQIGNQNKLI---QELKTA-KATLEQDSAKKEQQLQERCKALQDIQKEKSLKEK 1117

Query: 858  EWAVLKCRLEQLEE---KTENKLGELGSSAESKGALKKEREVHQKLLADSHSLV----MD 910
            E    K +L ++EE   + E ++ +L    +S   L+  +E+    L D+  L+    ++
Sbjct: 1118 ELVNEKSKLAEIEEIKCRQEKEITKLNEELKSH-KLESIKEITN--LKDAKQLLIQQKLE 1174

Query: 911  LRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQKENSPRRGG 964
            L+ +    +    +EK       D+ ++E E  KKEF+ +  +L  E   +  G
Sbjct: 1175 LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVG 1228



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 182/950 (19%), Positives = 373/950 (39%), Gaps = 120/950 (12%)

Query: 83  EEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDS 142
           E   A   D+   LRQ++ +++ S +  +   E LK+   K +  ++   +      D S
Sbjct: 75  ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134

Query: 143 ADLRC---QLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGP 199
           A+L+    QL+ A+ E F +++      ++  +L  E+   KS Y +  S     E    
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194

Query: 200 PSTREAELK------LRLKLVE----EEANILGRKIVELE--VENRGLKAEMEDMRGQQE 247
             T E   +      L+ +L++    E+  +L +++V+++  ++N  L+ E E  + + E
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254

Query: 248 REGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVE---EEAELLRRSISEIEDHNRQLTH 304
            +     +A S  T       +  +EL +  Q V    +E + L+ S++E+   N+ LT 
Sbjct: 255 CKKLQSQYASSEATIS-----QLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTE 309

Query: 305 ELSKFKFEPPREPGWLGEGASPGAGGGAPL-QEELKSARLQISELSGKVLKLQHENHALL 363
            L K + +  +      E +       A L Q++L   +LQ S LS     L H  H  L
Sbjct: 310 NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQ-SRLSASETSL-HRIHVEL 367

Query: 364 SNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGG---ESDSEE 420
           S           G      ++  +E +   +    E  +L Q + E    G   +S+  +
Sbjct: 368 SE---------KGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQ 418

Query: 421 MF------EKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITD 474
           +       E+  G   G+  E  +    +L+   +  + +  L+ +  RLE  ++  +T+
Sbjct: 419 LHSKLLETERQLGEAHGRLKEQRQLSSEKLM---DKEQQVADLQLKLSRLEEQLKEKVTN 475

Query: 475 TDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVN 534
           +    H                  ++  +  Q++  L  +  AK++  + +L+  L Q+ 
Sbjct: 476 STELQHQL----------------DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIG 519

Query: 535 RIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGP-----DLQSR---LKEQLEW 586
                +  L  L + S    ++    R+     +    G       LQ +   L+EQ+  
Sbjct: 520 DKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVT- 578

Query: 587 QLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEEL 646
           QL     ++ ES + +A   LH +                SLE            S+ EL
Sbjct: 579 QLTEKLKNQSESHK-QAQENLHDQVQEQKAHLRAAQDRVLSLE-----------TSVNEL 626

Query: 647 QGQLVQAA-RLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKN 705
             QL ++  ++ Q + +        +  E     +  +L+ H    QN L ++       
Sbjct: 627 NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK------- 679

Query: 706 LMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGG 765
             QQEL  +   +     KL+   +H  Q +   +E +E       +T    G++     
Sbjct: 680 --QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL-- 735

Query: 766 HQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRL-QTADRGQPHKQVVENQQLFSAFK 824
            +AD  +  + +       +     R    D  LR  + + + +  K++V + +L    K
Sbjct: 736 -EADSLEVKASKEQAL---QDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK 791

Query: 825 A-LLEDFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLE---------QLEEKT- 873
           +  LE  + +L + E  +  L+Q + +      ++   L  R++         ++E++  
Sbjct: 792 SEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEAL 851

Query: 874 -------ENKLGELGSSAE-SKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNRE 925
                  ++KL ++  S + SK   +KE +  +  + D      +L+ Q+    +N  +E
Sbjct: 852 MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911

Query: 926 KVELLDRLDRDRQEWERQKKEFLWRIEQLQKENSPRRGGSFLCDQKDGNV 975
           + EL   L+++++   + K E     EQL +  +  +       Q  GN+
Sbjct: 912 QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNI 961



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 135/770 (17%), Positives = 302/770 (39%), Gaps = 101/770 (13%)

Query: 9    LEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGEL-IRSLEQDLKV 67
            L+E V QL E  +    ++K  +   +   + ++  L+ A+   +  E  +  L   L  
Sbjct: 573  LQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNE 632

Query: 68   AKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIE-VEISKQALQNELERLKESSLKRRS 126
            +K+   +L  ++K   E    AE      R  +   ++ ++ ALQ++ + L + + +   
Sbjct: 633  SKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQ 692

Query: 127  TREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELE------------ 174
                 ++K    Q+  + L   L+  KE+   + +K  +L  +  +LE            
Sbjct: 693  VTAKLQDK----QEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ 748

Query: 175  --QELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVEN 232
              Q+LQ+ + L  D++              R  EL    K +E E  I+    ++L+ ++
Sbjct: 749  ALQDLQQQRQLNTDLE-------------LRATELS---KQLEMEKEIVSSTRLDLQKKS 792

Query: 233  RGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRR---HLQFVEEEAELLR 289
              L++  + +  Q+E +   +    ++         E +  ++     LQ V+ E E L 
Sbjct: 793  EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALM 852

Query: 290  RSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELS 349
              +S ++D   +++  L   K E  +E          G      L++  K  + Q+    
Sbjct: 853  TELSTVKDKLSKVSDSLKNSKSEFEKEN-------QKGKAAILDLEKTCKELKHQLQVQM 905

Query: 350  GKVLKLQHENHALLSNIQRCDLAAH-LGLRAPSPRDSDAESDAGKKESDGEESRLPQPKR 408
               LK Q E   L  ++++   A+H L L   S ++   ++    K+++ EE +L     
Sbjct: 906  ENTLKEQKE---LKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL----- 957

Query: 409  EGPVGGESDSEEMFEKTSGFGSGK-------PSEASEPCPTELLKARED----SEYLVTL 457
            +G +     S E  +K      G+        +E       +L +A ++     E +  L
Sbjct: 958  QGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVL 1017

Query: 458  KHEAQRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINA 517
            ++  ++ + T ++L +D                      G E +    +Q+   L ++  
Sbjct: 1018 QNNYEKSQETFKQLQSD--------------------FYGRESELLATRQD---LKSVEE 1054

Query: 518  KMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQ 577
            K+   +++L   +   N+IG+    +  L  + + L    S  ++  +    K L    +
Sbjct: 1055 KLSLAQEDL---ISNRNQIGNQNKLIQELKTAKATLEQ-DSAKKEQQLQERCKALQDIQK 1110

Query: 578  SRLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLP 637
             +  ++ E     ++  E E ++ R  +E+  + + +  SH L      +       +L 
Sbjct: 1111 EKSLKEKELVNEKSKLAEIEEIKCRQEKEI-TKLNEELKSHKLESIKEITNLKDAKQLLI 1169

Query: 638  EQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHE 697
            +Q + ++     L  A    +   +   +++ K EEE       KE ++HS   +  +  
Sbjct: 1170 QQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGM 1229

Query: 698  RTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTE 747
            +   + +  +  ++ +L +N       L  + K W+  ++   E E+ T+
Sbjct: 1230 KKHEENEAKLTMQITALNEN-------LGTVKKEWQSSQRRVSELEKQTD 1272



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 194/989 (19%), Positives = 382/989 (38%), Gaps = 130/989 (13%)

Query: 2   EEMRD--SYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIR 59
           +E++D  + L+E+ +  +EL++EL++           L++ E K   +      +   ++
Sbjct: 90  QEVQDLQASLKEEKWYSEELKKELEKYQG--------LQQQEAKPDGLVTDSSAE---LQ 138

Query: 60  SLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKE 119
           SLEQ L+ A+  +  +       E+K A+   E   ++ +  E    ++A + ++ RL E
Sbjct: 139 SLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTE 198

Query: 120 SSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQK 179
             L + +T     + +   +    D+    +   +   LM     +  RE ++L+ E +K
Sbjct: 199 -ELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKK 257

Query: 180 YKSLYGDVD---SPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLK 236
            +S Y   +   S L +  A GP     A     L+ ++   N L +K   L      L 
Sbjct: 258 LQSQYASSEATISQLRSELAKGPQEV--AVYVQELQKLKSSVNELTQKNQTL---TENLL 312

Query: 237 AEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIE 296
            + +D    +E+         +I  +     L+   +L+  L   E     +   +SE  
Sbjct: 313 KKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ-QLQSRLSASETSLHRIHVELSEKG 371

Query: 297 DHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQ 356
           +  ++L  ELS+ + +                     L+ E K  + Q  E     L+LQ
Sbjct: 372 EATQKLKEELSEVETKYQH------------------LKAEFKQLQQQREEKEQHGLQLQ 413

Query: 357 HE---NHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGE--ESRLPQPKREGP 411
            E    H+ L   +R    AH  L+      S+   D  ++ +D +   SRL +  +E  
Sbjct: 414 SEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKE-K 472

Query: 412 VGGESDSEEMFEKT----------SGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEA 461
           V   ++ +   +KT              + K  EA       L +  +  + +  L+   
Sbjct: 473 VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 532

Query: 462 QRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKA 521
           Q+ +  +  L  + +     A ++ G        Q +E+     +Q  QL   +  + ++
Sbjct: 533 QKSKENISLLEKEREDLY--AKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSES 590

Query: 522 FKKELQAFLEQVNRIGDGLSPLPHLTESSS-FLSTVTSVSRDSPIGNLGKELGPDLQSRL 580
            K+  +   +QV           HL  +    LS  TSV+  +   N  KE    L  ++
Sbjct: 591 HKQAQENLHDQVQ------EQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQI 644

Query: 581 KEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPV---LP 637
           K + E  L        E+ +     +L    D    +     Q    +  +   V   L 
Sbjct: 645 KAKTELLL------SAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ 698

Query: 638 EQSVSIEELQGQLVQAARLH---QEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNT 694
           ++     +L+  L +    +   +++TE    +I K+E + L     KE  +  L  Q  
Sbjct: 699 DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQ 758

Query: 695 LHE----RTWSDEKNL-MQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGE 749
           L+     R     K L M++E+ S  +   L   K    L+  +Q    +EE ++  + +
Sbjct: 759 LNTDLELRATELSKQLEMEKEIVSSTR---LDLQKKSEALESIKQKLTKQEEEKQILKQD 815

Query: 750 HPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQP 809
             ETLS+                                 +++Q  + + R+QT    + 
Sbjct: 816 F-ETLSQ--------------------------------ETKIQHEELNNRIQTTVT-EL 841

Query: 810 HKQVVENQQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAA-WDVEWAVLKCRLEQ 868
            K  +E + L +    + +         + ++   +++    KAA  D+E    + +  Q
Sbjct: 842 QKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK-HQ 900

Query: 869 LEEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVE 928
           L+ + EN L E     E K +L+KE+E   +L  + +S+   L  Q  ++ K   +E+ +
Sbjct: 901 LQVQMENTLKE---QKELKKSLEKEKEASHQLKLELNSMQEQL-IQAQNTLKQNEKEEQQ 956

Query: 929 LLDRLDRDRQEWERQKKEFLWRIEQLQKE 957
           L   ++  +Q  E++KK+    IE LQ E
Sbjct: 957 LQGNINELKQSSEQKKKQ----IEALQGE 981


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 228/1154 (19%), Positives = 435/1154 (37%), Gaps = 146/1154 (12%)

Query: 9    LEEDV----YQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETG-----QVDGELIR 59
            +EE++     QL+   R+   A    + L+ R  +AE +  +  E       QV  E  R
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509

Query: 60   SLEQDLKVAKDVSVRLH------HELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNE 113
              + ++++A  V             L+ +EE R +AE+    LRQ  +E     Q     
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1569

Query: 114  LERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDEL 173
             +R  E+ L  +S R  + EK    +    +    +   +EEA    ++ A+  R ++E 
Sbjct: 1570 AQRSAEAEL--QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627

Query: 174  EQELQKYKSLYG----------DVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGR 223
            E+EL++++              +V       +A       EAE + R +   EE  +  R
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687

Query: 224  KIVELEVE----------NRGLKAEMEDMR-------GQQEREGPGRDHAPSIPTSPFGD 266
            ++ E E+E           + L AE E +R       G+Q+R+    + A          
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL--QREAAA 1745

Query: 267  SLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASP 326
            + +   EL   L  V  E E+L  S +  E+ +R  T E SK + E   E G   E A  
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRS-TSEKSKQRLE--AEAGRFRELAEE 1802

Query: 327  GAGGGAPLQEELKSARLQISELSGK----VLKLQHENHALLSNIQRCDLAAHLGLRAPSP 382
             A   A L EE K  R    E + +      ++  E  A +    R    A + L     
Sbjct: 1803 AARLRA-LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL----- 1856

Query: 383  RDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPT 442
            ++ +AE++  ++ ++ +E+   +   E     ++D EE   +       +          
Sbjct: 1857 KEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915

Query: 443  ELLKAREDSEYLVTLKHEAQR-------LERTVERLITDTDSFLHDAGLRGGAPLPGPGL 495
             L + R+  E ++ LK   ++       LE  + R+ ++ +  L               L
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975

Query: 496  QGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLST 555
              EEE+   + +E ++  ++ A+ +A  ++ +A LE+V R+   +     L E +   S 
Sbjct: 1976 AAEEERRRREAEE-RVQKSLAAEEEA-ARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033

Query: 556  ---------------VTSVSRDSPIGNLGKELGPDLQSR--LKEQLEWQLGPAR--GDER 596
                               +    +    +EL   LQ    + +QL  +   AR   +E 
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093

Query: 597  ESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQ-----GQLV 651
            E  R++A RE  +       +  L        + R       + +  E  Q      Q  
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153

Query: 652  QAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQQEL 711
            QAA   ++  +    K  K  E+ L      E E+ +L LQ  L E     +KNL+ +EL
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ--LEET--DHQKNLLDEEL 2209

Query: 712  RSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL-GELGVQG------ 764
            + LK              +  RQ  Q+EE  E F+     E LS+L   +  +       
Sbjct: 2210 QRLKAE----------ATEAARQRSQVEE--ELFSVRVQMEELSKLKARIEAENRALILR 2257

Query: 765  ---------GHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVE 815
                       +A+     ++      V         Q+ +  L  Q A   +  K+ ++
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2317

Query: 816  NQQLFSAFKALLE--DFRAELREDERARLRLQQQYASDKAAWDVEW---AVLKCRLEQLE 870
              Q  +  KA  E    + EL +++  RL+  ++  + + A + +     +   R  QLE
Sbjct: 2318 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377

Query: 871  EKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELL 930
               E +  +L  +  S+   + E +  +           ++  ++H +E    +EKV L+
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQR-----FRKQAEEIGEKLHRTELA-TQEKVTLV 2431

Query: 931  DRLDRDRQEWERQKKEFLWRIEQLQKENSPRRGGSFLCDQKDGNVRPFPHQGSLRMPRPV 990
              L+  RQ+ +   +     I +L++E    +  + L   K   ++    +  L+  + +
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2491

Query: 991  AMWPCADADSIPFEDRPLSKLKESDRCSASENLYLDALSLDDEPEEPPAHRPEREFRNRL 1050
                 ++ DS          L + +R    E   L+ L  D+  +       ++  + ++
Sbjct: 2492 QQSFLSEKDS----------LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541

Query: 1051 PEEEENHKGNLQRA 1064
             +E +    +++ A
Sbjct: 2542 EQERQRLVASMEEA 2555



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 176/928 (18%), Positives = 340/928 (36%), Gaps = 93/928 (10%)

Query: 25   RANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLH-HELKTVE 83
            +A +  + LQ R+++   +  + A   Q     I+   Q L+ + +  ++    + +  E
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1444

Query: 84   EKRAKAEDENETLRQQMIEVEISKQALQNELE----RLKESSLKRRSTREMYKEKKTFNQ 139
              R + E+E   +R Q+   E  +   + EL+    R +E+  ++R  +E  +  +   Q
Sbjct: 1445 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504

Query: 140  DDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGP 199
            D+S   R     A+ E     K  A+  REK    Q L++ +    + +  L   E    
Sbjct: 1505 DESQRKR----QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1560

Query: 200  PSTR----------EAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQERE 249
               +          EAEL+ +     E+   L R + E  V    L+ E E    QQ   
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620

Query: 250  GPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKF 309
               R+              E+  EL R  Q    EA  LR    E+         E  K 
Sbjct: 1621 ERARE--------------EAERELER-WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1665

Query: 310  KFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRC 369
            K E  RE    G+            ++EL+  R      + + L  + E   L +  ++ 
Sbjct: 1666 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725

Query: 370  DLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFG 429
            +    L     +    +A +   K++    E    + + E  +  ++ +EE    TS   
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785

Query: 430  -------SGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDA 482
                   +G+  E +E        A E        + +A R     ER++ +  + + +A
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1845

Query: 483  -GLRGGAPLPGPGLQGEEEQ----GEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIG 537
              L+  A +     + E E+     E +  + + L    A+ KA   +++  L Q+ +  
Sbjct: 1846 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERLAQLRKAS 1902

Query: 538  DGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERE 597
            D       L      +       R      L  +   +  +  K +LE +LG  R +  +
Sbjct: 1903 DS-----ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957

Query: 598  SLR------LRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSV--SIEELQGQ 649
            +LR      L AAR+    A+ +        +   SL          ++    +E L+ +
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017

Query: 650  LVQAARLH-----------QEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTL-HE 697
            + +A RL            Q   E    ++   E+ H +A++ KE E     LQ TL  E
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-----LQQTLQQE 2072

Query: 698  RTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL 757
            ++  D+     +  R   +      V+     +   Q ++  EE E   +    +  +R 
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARA 2129

Query: 758  GELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQ 817
                     + +     + R       E +   + Q  D  +        Q  +Q  + +
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRA----QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185

Query: 818  QLFSAFKALLE--DFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTEN 875
            Q  +  +  LE  D +  L ++E  RL+ +   A+ + +  VE  +   R+ Q+EE ++ 
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS-QVEEELFSVRV-QMEELSKL 2243

Query: 876  KLGELGSSAESKGALKKEREVHQKLLAD 903
            K       AE++  + ++++  Q+ L +
Sbjct: 2244 K---ARIEAENRALILRDKDNTQRFLQE 2268



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 137/623 (21%), Positives = 247/623 (39%), Gaps = 75/623 (12%)

Query: 11   EDVYQLQELRRELDRANKNCRILQYRLRK-AEQKSLKVAETGQVDGELIRSLEQDLKVAK 69
            E+  +L++   E  +A    +    +LRK AEQ++ + A+  Q       +L Q  K A 
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA------ALRQ--KQAA 2163

Query: 70   DVSVRLHHEL--KTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRST 127
            D  +  H +   +T+ +K A+ E E  TLR Q+ E +  K  L  EL+RLK  +      
Sbjct: 2164 DAEMEKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA------ 2216

Query: 128  REMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDV 187
                         ++A  R Q++   EE F +R +M +L + K  +E E +    +  D 
Sbjct: 2217 ------------TEAARQRSQVE---EELFSVRVQMEELSKLKARIEAENRAL--ILRDK 2259

Query: 188  DSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQE 247
            D+     +       + AE   RL +  +EA  L +   E   + R L  +M   + Q  
Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2319

Query: 248  REGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELS 307
            +E         +         E + E  R LQ  E++ ++ ++   E +   R L  E  
Sbjct: 2320 QEATRLKAEAEL----LQQQKELAQEQARRLQ--EDKEQMAQQLAEETQGFQRTLEAERQ 2373

Query: 308  KFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQ 367
            + + E   E   L    +  +   A  +E+ +  R Q  E+  K+ + +      ++ +Q
Sbjct: 2374 R-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432

Query: 368  RCDLAAHLGLRAPSPRDSDAESDA-----GKKESDGEESRLPQPKRE--GPVGGESDSEE 420
              ++      R  S  D++   +A      +KE   +E++L Q K E    V  E   +E
Sbjct: 2433 TLEIQ-----RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487

Query: 421  MFEKTSGFGSGKPSEASEPCPTELLKAR------EDSEYLVTLKHEAQRLERTVERLITD 474
                   F S K S        E  KA+      ++      L+ E QR ++ +E+    
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2547

Query: 475  TDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQ--QEPQLLGTINAKMKAFKKELQAFLEQ 532
              + + +A  R      G   + EE Q    Q  Q+ +LL   N ++   +++LQ  LE+
Sbjct: 2548 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL---REQLQ-LLEE 2603

Query: 533  VNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPAR 592
             +R          L  S    ++  + ++  P G    + GP  ++  +   +       
Sbjct: 2604 QHRAA--------LAHSEEVTASQVAATKTLPNGRDALD-GPAAEAEPEHSFDGLRRKVS 2654

Query: 593  GDERESLRLRAARELHRRADGDT 615
                +   + +A EL R A G T
Sbjct: 2655 AQRLQEAGILSAEELQRLAQGHT 2677



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 204/988 (20%), Positives = 374/988 (37%), Gaps = 196/988 (19%)

Query: 36   RLRKAEQKSLKVAETGQVDGELIRSLEQDL---KVAKDVSVRLHHELKTVEEKRAKAEDE 92
            RL    +K L + E       L   LE  L   +  + +S     +LKT+       +  
Sbjct: 1042 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1101

Query: 93   NETLR---QQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQL 149
             E LR   +Q+ E +     L  ELE  K S  K R+  E   ++ TF+      LR +L
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEA--QQPTFDA-----LRDEL 1153

Query: 150  QFAKEEAFLMRKKMAK----LGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREA 205
            + A+E    ++++  +    + R ++ + Q L++++++    D              R+ 
Sbjct: 1154 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD-------------VRQR 1200

Query: 206  ELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFG 265
            EL+            LGR++         L A ++D R +QE+          I   P  
Sbjct: 1201 ELEQ-----------LGRQLRYYRESADPLGAWLQDARRRQEQ----------IQAMPLA 1239

Query: 266  DSLESSTELR----------RHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPR 315
            DS     +LR          RH + VEE     ++ I+ I+D+  QL     K + EP  
Sbjct: 1240 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV--TYKAQLEPVA 1297

Query: 316  EPGWLGEGASPGAGGGAPLQE--ELKSARLQISELSGKVLKL------QHENHALLSNIQ 367
             P    +     +G  + +QE  +L++   +++ L+ + +K       + E    L+  Q
Sbjct: 1298 SP---AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1354

Query: 368  RCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSG 427
            R +    L        + +A  +  ++ ++       Q +RE     +   EE+  +   
Sbjct: 1355 RAEERERLA-------EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1407

Query: 428  FGSGKPSEASEPCPTELLKAREDSEYLVTLK-HEAQRLERTVERLITDTDSFLHDAGLRG 486
                +  + S     EL + R+ SE  +  K  +A+  ER+  R+    +  +    L+ 
Sbjct: 1408 AVDAQQQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRI----EEEIRVVRLQ- 1460

Query: 487  GAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHL 546
                    L+  E Q  G + E Q L     + +A K++ Q   E++ R           
Sbjct: 1461 --------LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR----------- 1501

Query: 547  TESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDER-----ESLRL 601
                        V  +S      ++   +L SR+K + E     AR  +R     E LRL
Sbjct: 1502 -----------QVQDES---QRKRQAEVELASRVKAEAE----AAREKQRALQALEELRL 1543

Query: 602  RAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEET 661
            + A E  RR                   LR   V   + V +     Q    A L Q + 
Sbjct: 1544 Q-AEEAERR-------------------LRQAEVERARQVQVALETAQRSAEAEL-QSKR 1582

Query: 662  ETFTNKIHKME----EEHLYALRWKELEMHSLALQNTLHERTWSD-EKNLMQQELRSLKQ 716
             +F  K  ++E    EEH+   + +E E    A Q    ER   + E+ L + +L++ + 
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLRE-EAERRAQQQAEAERAREEAERELERWQLKANEA 1641

Query: 717  NIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSD 776
                  ++LR   +   Q K + +   E  + E      R G+   Q   Q +  + + +
Sbjct: 1642 ------LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1695

Query: 777  RGCGFPVGEHSPHSRVQIGDHSLRLQT-ADRGQPHKQVVENQ------------QLFSAF 823
            +     + E +   R+      +RL+   ++G+  +Q++E +            Q     
Sbjct: 1696 K--QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753

Query: 824  KALLEDFRAEL----------REDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKT 873
            +A L   RAE+           E+ R+     +Q    +A    E A    RL  L E+ 
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1813

Query: 874  ENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELL--- 930
            + +  +L     ++   + ER + +KL A   +  +    +I   EK    E++  L   
Sbjct: 1814 KRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872

Query: 931  DRLDRDRQEWE--RQKKEFLWRIEQLQK 956
            +   R R E +  + K +   R+ QL+K
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLRK 1900



 Score = 38.9 bits (89), Expect = 0.040
 Identities = 87/408 (21%), Positives = 169/408 (41%), Gaps = 56/408 (13%)

Query: 577  QSRLKEQLE-WQLGPARGDERESLRLRAAREL-HRRADGDTGSHGLGGQTCFSLELRGPP 634
            + R+ + LE WQ   A+ D R+    +  R+L + R   D     L        +++  P
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 635  VLPEQSVSIEELQGQ-LVQAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQN 693
            +   Q+V  +  Q Q L++    H E+ E    +  +  ++++ A++  EL++ +   Q 
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVE----ECQRFAKQYINAIKDYELQLVTYKAQL 1293

Query: 694  TLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRW-----------LLKHWRQGKQMEEEG 742
               E   S  K   + +++S  +++   YV LR             +K   +  +  EE 
Sbjct: 1294 ---EPVASPAK---KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE 1347

Query: 743  EEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQ 802
            E   E +  E   RL E  V+   +      ++           +   + ++ +  +R +
Sbjct: 1348 ERLAEQQRAEERERLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1405

Query: 803  TA--DRGQPHKQVVEN-QQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEW 859
             A  D  Q  + + E  QQL  + +A ++    +    ER+RLR+++           E 
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE-----------EI 1454

Query: 860  AVLKCRLEQLEEK---TENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIH 916
             V++ +LE  E +    E +L  L + AE   A K++ +   +           LR Q+ 
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE----------RLRRQVQ 1504

Query: 917  HSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQ--LQKENSPRR 962
               +   + +VEL  R+ +   E  R+K+  L  +E+  LQ E + RR
Sbjct: 1505 DESQRKRQAEVELASRV-KAEAEAAREKQRALQALEELRLQAEEAERR 1551


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 228/1154 (19%), Positives = 435/1154 (37%), Gaps = 146/1154 (12%)

Query: 9    LEEDV----YQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETG-----QVDGELIR 59
            +EE++     QL+   R+   A    + L+ R  +AE +  +  E       QV  E  R
Sbjct: 1454 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513

Query: 60   SLEQDLKVAKDVSVRLH------HELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNE 113
              + ++++A  V             L+ +EE R +AE+    LRQ  +E     Q     
Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1573

Query: 114  LERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDEL 173
             +R  E+ L  +S R  + EK    +    +    +   +EEA    ++ A+  R ++E 
Sbjct: 1574 AQRSAEAEL--QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1631

Query: 174  EQELQKYKSLYG----------DVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGR 223
            E+EL++++              +V       +A       EAE + R +   EE  +  R
Sbjct: 1632 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1691

Query: 224  KIVELEVE----------NRGLKAEMEDMR-------GQQEREGPGRDHAPSIPTSPFGD 266
            ++ E E+E           + L AE E +R       G+Q+R+    + A          
Sbjct: 1692 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL--QREAAA 1749

Query: 267  SLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASP 326
            + +   EL   L  V  E E+L  S +  E+ +R  T E SK + E   E G   E A  
Sbjct: 1750 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRS-TSEKSKQRLE--AEAGRFRELAEE 1806

Query: 327  GAGGGAPLQEELKSARLQISELSGK----VLKLQHENHALLSNIQRCDLAAHLGLRAPSP 382
             A   A L EE K  R    E + +      ++  E  A +    R    A + L     
Sbjct: 1807 AARLRA-LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL----- 1860

Query: 383  RDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPT 442
            ++ +AE++  ++ ++ +E+   +   E     ++D EE   +       +          
Sbjct: 1861 KEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1919

Query: 443  ELLKAREDSEYLVTLKHEAQR-------LERTVERLITDTDSFLHDAGLRGGAPLPGPGL 495
             L + R+  E ++ LK   ++       LE  + R+ ++ +  L               L
Sbjct: 1920 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1979

Query: 496  QGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLST 555
              EEE+   + +E ++  ++ A+ +A  ++ +A LE+V R+   +     L E +   S 
Sbjct: 1980 AAEEERRRREAEE-RVQKSLAAEEEA-ARQRKAALEEVERLKAKVEEARRLRERAEQESA 2037

Query: 556  ---------------VTSVSRDSPIGNLGKELGPDLQSR--LKEQLEWQLGPAR--GDER 596
                               +    +    +EL   LQ    + +QL  +   AR   +E 
Sbjct: 2038 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2097

Query: 597  ESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQ-----GQLV 651
            E  R++A RE  +       +  L        + R       + +  E  Q      Q  
Sbjct: 2098 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2157

Query: 652  QAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQQEL 711
            QAA   ++  +    K  K  E+ L      E E+ +L LQ  L E     +KNL+ +EL
Sbjct: 2158 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ--LEET--DHQKNLLDEEL 2213

Query: 712  RSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL-GELGVQG------ 764
            + LK              +  RQ  Q+EE  E F+     E LS+L   +  +       
Sbjct: 2214 QRLKAE----------ATEAARQRSQVEE--ELFSVRVQMEELSKLKARIEAENRALILR 2261

Query: 765  ---------GHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVE 815
                       +A+     ++      V         Q+ +  L  Q A   +  K+ ++
Sbjct: 2262 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2321

Query: 816  NQQLFSAFKALLE--DFRAELREDERARLRLQQQYASDKAAWDVEW---AVLKCRLEQLE 870
              Q  +  KA  E    + EL +++  RL+  ++  + + A + +     +   R  QLE
Sbjct: 2322 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2381

Query: 871  EKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELL 930
               E +  +L  +  S+   + E +  +           ++  ++H +E    +EKV L+
Sbjct: 2382 MSAEAERLKLRVAEMSRAQARAEEDAQR-----FRKQAEEIGEKLHRTELA-TQEKVTLV 2435

Query: 931  DRLDRDRQEWERQKKEFLWRIEQLQKENSPRRGGSFLCDQKDGNVRPFPHQGSLRMPRPV 990
              L+  RQ+ +   +     I +L++E    +  + L   K   ++    +  L+  + +
Sbjct: 2436 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2495

Query: 991  AMWPCADADSIPFEDRPLSKLKESDRCSASENLYLDALSLDDEPEEPPAHRPEREFRNRL 1050
                 ++ DS          L + +R    E   L+ L  D+  +       ++  + ++
Sbjct: 2496 QQSFLSEKDS----------LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2545

Query: 1051 PEEEENHKGNLQRA 1064
             +E +    +++ A
Sbjct: 2546 EQERQRLVASMEEA 2559



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 176/928 (18%), Positives = 340/928 (36%), Gaps = 93/928 (10%)

Query: 25   RANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLH-HELKTVE 83
            +A +  + LQ R+++   +  + A   Q     I+   Q L+ + +  ++    + +  E
Sbjct: 1389 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1448

Query: 84   EKRAKAEDENETLRQQMIEVEISKQALQNELE----RLKESSLKRRSTREMYKEKKTFNQ 139
              R + E+E   +R Q+   E  +   + EL+    R +E+  ++R  +E  +  +   Q
Sbjct: 1449 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1508

Query: 140  DDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGP 199
            D+S   R     A+ E     K  A+  REK    Q L++ +    + +  L   E    
Sbjct: 1509 DESQRKR----QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1564

Query: 200  PSTR----------EAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQERE 249
               +          EAEL+ +     E+   L R + E  V    L+ E E    QQ   
Sbjct: 1565 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1624

Query: 250  GPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKF 309
               R+              E+  EL R  Q    EA  LR    E+         E  K 
Sbjct: 1625 ERARE--------------EAERELER-WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1669

Query: 310  KFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRC 369
            K E  RE    G+            ++EL+  R      + + L  + E   L +  ++ 
Sbjct: 1670 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1729

Query: 370  DLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFG 429
            +    L     +    +A +   K++    E    + + E  +  ++ +EE    TS   
Sbjct: 1730 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1789

Query: 430  -------SGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDA 482
                   +G+  E +E        A E        + +A R     ER++ +  + + +A
Sbjct: 1790 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1849

Query: 483  -GLRGGAPLPGPGLQGEEEQ----GEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIG 537
              L+  A +     + E E+     E +  + + L    A+ KA   +++  L Q+ +  
Sbjct: 1850 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERLAQLRKAS 1906

Query: 538  DGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERE 597
            D       L      +       R      L  +   +  +  K +LE +LG  R +  +
Sbjct: 1907 DS-----ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1961

Query: 598  SLR------LRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSV--SIEELQGQ 649
            +LR      L AAR+    A+ +        +   SL          ++    +E L+ +
Sbjct: 1962 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2021

Query: 650  LVQAARLH-----------QEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTL-HE 697
            + +A RL            Q   E    ++   E+ H +A++ KE E     LQ TL  E
Sbjct: 2022 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-----LQQTLQQE 2076

Query: 698  RTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL 757
            ++  D+     +  R   +      V+     +   Q ++  EE E   +    +  +R 
Sbjct: 2077 QSVLDQLRGEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARA 2133

Query: 758  GELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQ 817
                     + +     + R       E +   + Q  D  +        Q  +Q  + +
Sbjct: 2134 QAQAAAEKLRKEAEQEAARRA----QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2189

Query: 818  QLFSAFKALLE--DFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTEN 875
            Q  +  +  LE  D +  L ++E  RL+ +   A+ + +  VE  +   R+ Q+EE ++ 
Sbjct: 2190 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS-QVEEELFSVRV-QMEELSKL 2247

Query: 876  KLGELGSSAESKGALKKEREVHQKLLAD 903
            K       AE++  + ++++  Q+ L +
Sbjct: 2248 K---ARIEAENRALILRDKDNTQRFLQE 2272



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 137/623 (21%), Positives = 247/623 (39%), Gaps = 75/623 (12%)

Query: 11   EDVYQLQELRRELDRANKNCRILQYRLRK-AEQKSLKVAETGQVDGELIRSLEQDLKVAK 69
            E+  +L++   E  +A    +    +LRK AEQ++ + A+  Q       +L Q  K A 
Sbjct: 2116 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA------ALRQ--KQAA 2167

Query: 70   DVSVRLHHEL--KTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRST 127
            D  +  H +   +T+ +K A+ E E  TLR Q+ E +  K  L  EL+RLK  +      
Sbjct: 2168 DAEMEKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA------ 2220

Query: 128  REMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDV 187
                         ++A  R Q++   EE F +R +M +L + K  +E E +    +  D 
Sbjct: 2221 ------------TEAARQRSQVE---EELFSVRVQMEELSKLKARIEAENRAL--ILRDK 2263

Query: 188  DSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQE 247
            D+     +       + AE   RL +  +EA  L +   E   + R L  +M   + Q  
Sbjct: 2264 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2323

Query: 248  REGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELS 307
            +E         +         E + E  R LQ  E++ ++ ++   E +   R L  E  
Sbjct: 2324 QEATRLKAEAEL----LQQQKELAQEQARRLQ--EDKEQMAQQLAEETQGFQRTLEAERQ 2377

Query: 308  KFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQ 367
            + + E   E   L    +  +   A  +E+ +  R Q  E+  K+ + +      ++ +Q
Sbjct: 2378 R-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2436

Query: 368  RCDLAAHLGLRAPSPRDSDAESDA-----GKKESDGEESRLPQPKRE--GPVGGESDSEE 420
              ++      R  S  D++   +A      +KE   +E++L Q K E    V  E   +E
Sbjct: 2437 TLEIQ-----RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2491

Query: 421  MFEKTSGFGSGKPSEASEPCPTELLKAR------EDSEYLVTLKHEAQRLERTVERLITD 474
                   F S K S        E  KA+      ++      L+ E QR ++ +E+    
Sbjct: 2492 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2551

Query: 475  TDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQ--QEPQLLGTINAKMKAFKKELQAFLEQ 532
              + + +A  R      G   + EE Q    Q  Q+ +LL   N ++   +++LQ  LE+
Sbjct: 2552 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL---REQLQ-LLEE 2607

Query: 533  VNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPAR 592
             +R          L  S    ++  + ++  P G    + GP  ++  +   +       
Sbjct: 2608 QHRAA--------LAHSEEVTASQVAATKTLPNGRDALD-GPAAEAEPEHSFDGLRRKVS 2658

Query: 593  GDERESLRLRAARELHRRADGDT 615
                +   + +A EL R A G T
Sbjct: 2659 AQRLQEAGILSAEELQRLAQGHT 2681



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 204/988 (20%), Positives = 374/988 (37%), Gaps = 196/988 (19%)

Query: 36   RLRKAEQKSLKVAETGQVDGELIRSLEQDL---KVAKDVSVRLHHELKTVEEKRAKAEDE 92
            RL    +K L + E       L   LE  L   +  + +S     +LKT+       +  
Sbjct: 1046 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1105

Query: 93   NETLR---QQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQL 149
             E LR   +Q+ E +     L  ELE  K S  K R+  E   ++ TF+      LR +L
Sbjct: 1106 EEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEA--QQPTFDA-----LRDEL 1157

Query: 150  QFAKEEAFLMRKKMAK----LGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREA 205
            + A+E    ++++  +    + R ++ + Q L++++++    D              R+ 
Sbjct: 1158 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD-------------VRQR 1204

Query: 206  ELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFG 265
            EL+            LGR++         L A ++D R +QE+          I   P  
Sbjct: 1205 ELEQ-----------LGRQLRYYRESADPLGAWLQDARRRQEQ----------IQAMPLA 1243

Query: 266  DSLESSTELR----------RHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPR 315
            DS     +LR          RH + VEE     ++ I+ I+D+  QL     K + EP  
Sbjct: 1244 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV--TYKAQLEPVA 1301

Query: 316  EPGWLGEGASPGAGGGAPLQE--ELKSARLQISELSGKVLKL------QHENHALLSNIQ 367
             P    +     +G  + +QE  +L++   +++ L+ + +K       + E    L+  Q
Sbjct: 1302 SP---AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1358

Query: 368  RCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSG 427
            R +    L        + +A  +  ++ ++       Q +RE     +   EE+  +   
Sbjct: 1359 RAEERERLA-------EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1411

Query: 428  FGSGKPSEASEPCPTELLKAREDSEYLVTLK-HEAQRLERTVERLITDTDSFLHDAGLRG 486
                +  + S     EL + R+ SE  +  K  +A+  ER+  R+    +  +    L+ 
Sbjct: 1412 AVDAQQQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRI----EEEIRVVRLQ- 1464

Query: 487  GAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHL 546
                    L+  E Q  G + E Q L     + +A K++ Q   E++ R           
Sbjct: 1465 --------LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR----------- 1505

Query: 547  TESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDER-----ESLRL 601
                        V  +S      ++   +L SR+K + E     AR  +R     E LRL
Sbjct: 1506 -----------QVQDES---QRKRQAEVELASRVKAEAE----AAREKQRALQALEELRL 1547

Query: 602  RAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEET 661
            + A E  RR                   LR   V   + V +     Q    A L Q + 
Sbjct: 1548 Q-AEEAERR-------------------LRQAEVERARQVQVALETAQRSAEAEL-QSKR 1586

Query: 662  ETFTNKIHKME----EEHLYALRWKELEMHSLALQNTLHERTWSD-EKNLMQQELRSLKQ 716
             +F  K  ++E    EEH+   + +E E    A Q    ER   + E+ L + +L++ + 
Sbjct: 1587 ASFAEKTAQLERSLQEEHVAVAQLRE-EAERRAQQQAEAERAREEAERELERWQLKANEA 1645

Query: 717  NIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSD 776
                  ++LR   +   Q K + +   E  + E      R G+   Q   Q +  + + +
Sbjct: 1646 ------LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1699

Query: 777  RGCGFPVGEHSPHSRVQIGDHSLRLQT-ADRGQPHKQVVENQ------------QLFSAF 823
            +     + E +   R+      +RL+   ++G+  +Q++E +            Q     
Sbjct: 1700 K--QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757

Query: 824  KALLEDFRAEL----------REDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKT 873
            +A L   RAE+           E+ R+     +Q    +A    E A    RL  L E+ 
Sbjct: 1758 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1817

Query: 874  ENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELL--- 930
            + +  +L     ++   + ER + +KL A   +  +    +I   EK    E++  L   
Sbjct: 1818 KRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1876

Query: 931  DRLDRDRQEWE--RQKKEFLWRIEQLQK 956
            +   R R E +  + K +   R+ QL+K
Sbjct: 1877 EAFQRRRLEEQAAQHKADIEERLAQLRK 1904



 Score = 38.9 bits (89), Expect = 0.040
 Identities = 87/408 (21%), Positives = 169/408 (41%), Gaps = 56/408 (13%)

Query: 577  QSRLKEQLE-WQLGPARGDERESLRLRAAREL-HRRADGDTGSHGLGGQTCFSLELRGPP 634
            + R+ + LE WQ   A+ D R+    +  R+L + R   D     L        +++  P
Sbjct: 1182 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1241

Query: 635  VLPEQSVSIEELQGQ-LVQAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQN 693
            +   Q+V  +  Q Q L++    H E+ E    +  +  ++++ A++  EL++ +   Q 
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVE----ECQRFAKQYINAIKDYELQLVTYKAQL 1297

Query: 694  TLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRW-----------LLKHWRQGKQMEEEG 742
               E   S  K   + +++S  +++   YV LR             +K   +  +  EE 
Sbjct: 1298 ---EPVASPAK---KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE 1351

Query: 743  EEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQ 802
            E   E +  E   RL E  V+   +      ++           +   + ++ +  +R +
Sbjct: 1352 ERLAEQQRAEERERLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1409

Query: 803  TA--DRGQPHKQVVEN-QQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEW 859
             A  D  Q  + + E  QQL  + +A ++    +    ER+RLR+++           E 
Sbjct: 1410 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE-----------EI 1458

Query: 860  AVLKCRLEQLEEK---TENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIH 916
             V++ +LE  E +    E +L  L + AE   A K++ +   +           LR Q+ 
Sbjct: 1459 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE----------RLRRQVQ 1508

Query: 917  HSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQ--LQKENSPRR 962
               +   + +VEL  R+ +   E  R+K+  L  +E+  LQ E + RR
Sbjct: 1509 DESQRKRQAEVELASRV-KAEAEAAREKQRALQALEELRLQAEEAERR 1555


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 228/1154 (19%), Positives = 435/1154 (37%), Gaps = 146/1154 (12%)

Query: 9    LEEDV----YQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETG-----QVDGELIR 59
            +EE++     QL+   R+   A    + L+ R  +AE +  +  E       QV  E  R
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509

Query: 60   SLEQDLKVAKDVSVRLH------HELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNE 113
              + ++++A  V             L+ +EE R +AE+    LRQ  +E     Q     
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1569

Query: 114  LERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDEL 173
             +R  E+ L  +S R  + EK    +    +    +   +EEA    ++ A+  R ++E 
Sbjct: 1570 AQRSAEAEL--QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627

Query: 174  EQELQKYKSLYG----------DVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGR 223
            E+EL++++              +V       +A       EAE + R +   EE  +  R
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687

Query: 224  KIVELEVE----------NRGLKAEMEDMR-------GQQEREGPGRDHAPSIPTSPFGD 266
            ++ E E+E           + L AE E +R       G+Q+R+    + A          
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL--QREAAA 1745

Query: 267  SLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASP 326
            + +   EL   L  V  E E+L  S +  E+ +R  T E SK + E   E G   E A  
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRS-TSEKSKQRLE--AEAGRFRELAEE 1802

Query: 327  GAGGGAPLQEELKSARLQISELSGK----VLKLQHENHALLSNIQRCDLAAHLGLRAPSP 382
             A   A L EE K  R    E + +      ++  E  A +    R    A + L     
Sbjct: 1803 AARLRA-LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL----- 1856

Query: 383  RDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPT 442
            ++ +AE++  ++ ++ +E+   +   E     ++D EE   +       +          
Sbjct: 1857 KEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915

Query: 443  ELLKAREDSEYLVTLKHEAQR-------LERTVERLITDTDSFLHDAGLRGGAPLPGPGL 495
             L + R+  E ++ LK   ++       LE  + R+ ++ +  L               L
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975

Query: 496  QGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLST 555
              EEE+   + +E ++  ++ A+ +A  ++ +A LE+V R+   +     L E +   S 
Sbjct: 1976 AAEEERRRREAEE-RVQKSLAAEEEA-ARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033

Query: 556  ---------------VTSVSRDSPIGNLGKELGPDLQSR--LKEQLEWQLGPAR--GDER 596
                               +    +    +EL   LQ    + +QL  +   AR   +E 
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093

Query: 597  ESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQ-----GQLV 651
            E  R++A RE  +       +  L        + R       + +  E  Q      Q  
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153

Query: 652  QAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQQEL 711
            QAA   ++  +    K  K  E+ L      E E+ +L LQ  L E     +KNL+ +EL
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ--LEET--DHQKNLLDEEL 2209

Query: 712  RSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL-GELGVQG------ 764
            + LK              +  RQ  Q+EE  E F+     E LS+L   +  +       
Sbjct: 2210 QRLKAE----------ATEAARQRSQVEE--ELFSVRVQMEELSKLKARIEAENRALILR 2257

Query: 765  ---------GHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVE 815
                       +A+     ++      V         Q+ +  L  Q A   +  K+ ++
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2317

Query: 816  NQQLFSAFKALLE--DFRAELREDERARLRLQQQYASDKAAWDVEW---AVLKCRLEQLE 870
              Q  +  KA  E    + EL +++  RL+  ++  + + A + +     +   R  QLE
Sbjct: 2318 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377

Query: 871  EKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELL 930
               E +  +L  +  S+   + E +  +           ++  ++H +E    +EKV L+
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQR-----FRKQAEEIGEKLHRTELA-TQEKVTLV 2431

Query: 931  DRLDRDRQEWERQKKEFLWRIEQLQKENSPRRGGSFLCDQKDGNVRPFPHQGSLRMPRPV 990
              L+  RQ+ +   +     I +L++E    +  + L   K   ++    +  L+  + +
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2491

Query: 991  AMWPCADADSIPFEDRPLSKLKESDRCSASENLYLDALSLDDEPEEPPAHRPEREFRNRL 1050
                 ++ DS          L + +R    E   L+ L  D+  +       ++  + ++
Sbjct: 2492 QQSFLSEKDS----------LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541

Query: 1051 PEEEENHKGNLQRA 1064
             +E +    +++ A
Sbjct: 2542 EQERQRLVASMEEA 2555



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 176/928 (18%), Positives = 340/928 (36%), Gaps = 93/928 (10%)

Query: 25   RANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLH-HELKTVE 83
            +A +  + LQ R+++   +  + A   Q     I+   Q L+ + +  ++    + +  E
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1444

Query: 84   EKRAKAEDENETLRQQMIEVEISKQALQNELE----RLKESSLKRRSTREMYKEKKTFNQ 139
              R + E+E   +R Q+   E  +   + EL+    R +E+  ++R  +E  +  +   Q
Sbjct: 1445 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504

Query: 140  DDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGP 199
            D+S   R     A+ E     K  A+  REK    Q L++ +    + +  L   E    
Sbjct: 1505 DESQRKR----QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1560

Query: 200  PSTR----------EAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQERE 249
               +          EAEL+ +     E+   L R + E  V    L+ E E    QQ   
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620

Query: 250  GPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKF 309
               R+              E+  EL R  Q    EA  LR    E+         E  K 
Sbjct: 1621 ERARE--------------EAERELER-WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1665

Query: 310  KFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRC 369
            K E  RE    G+            ++EL+  R      + + L  + E   L +  ++ 
Sbjct: 1666 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725

Query: 370  DLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFG 429
            +    L     +    +A +   K++    E    + + E  +  ++ +EE    TS   
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785

Query: 430  -------SGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDA 482
                   +G+  E +E        A E        + +A R     ER++ +  + + +A
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1845

Query: 483  -GLRGGAPLPGPGLQGEEEQ----GEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIG 537
              L+  A +     + E E+     E +  + + L    A+ KA   +++  L Q+ +  
Sbjct: 1846 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERLAQLRKAS 1902

Query: 538  DGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERE 597
            D       L      +       R      L  +   +  +  K +LE +LG  R +  +
Sbjct: 1903 DS-----ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957

Query: 598  SLR------LRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSV--SIEELQGQ 649
            +LR      L AAR+    A+ +        +   SL          ++    +E L+ +
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017

Query: 650  LVQAARLH-----------QEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTL-HE 697
            + +A RL            Q   E    ++   E+ H +A++ KE E     LQ TL  E
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-----LQQTLQQE 2072

Query: 698  RTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL 757
            ++  D+     +  R   +      V+     +   Q ++  EE E   +    +  +R 
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARA 2129

Query: 758  GELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQ 817
                     + +     + R       E +   + Q  D  +        Q  +Q  + +
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRA----QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185

Query: 818  QLFSAFKALLE--DFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTEN 875
            Q  +  +  LE  D +  L ++E  RL+ +   A+ + +  VE  +   R+ Q+EE ++ 
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS-QVEEELFSVRV-QMEELSKL 2243

Query: 876  KLGELGSSAESKGALKKEREVHQKLLAD 903
            K       AE++  + ++++  Q+ L +
Sbjct: 2244 K---ARIEAENRALILRDKDNTQRFLQE 2268



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 137/623 (21%), Positives = 247/623 (39%), Gaps = 75/623 (12%)

Query: 11   EDVYQLQELRRELDRANKNCRILQYRLRK-AEQKSLKVAETGQVDGELIRSLEQDLKVAK 69
            E+  +L++   E  +A    +    +LRK AEQ++ + A+  Q       +L Q  K A 
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA------ALRQ--KQAA 2163

Query: 70   DVSVRLHHEL--KTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRST 127
            D  +  H +   +T+ +K A+ E E  TLR Q+ E +  K  L  EL+RLK  +      
Sbjct: 2164 DAEMEKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA------ 2216

Query: 128  REMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDV 187
                         ++A  R Q++   EE F +R +M +L + K  +E E +    +  D 
Sbjct: 2217 ------------TEAARQRSQVE---EELFSVRVQMEELSKLKARIEAENRAL--ILRDK 2259

Query: 188  DSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQE 247
            D+     +       + AE   RL +  +EA  L +   E   + R L  +M   + Q  
Sbjct: 2260 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2319

Query: 248  REGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELS 307
            +E         +         E + E  R LQ  E++ ++ ++   E +   R L  E  
Sbjct: 2320 QEATRLKAEAEL----LQQQKELAQEQARRLQ--EDKEQMAQQLAEETQGFQRTLEAERQ 2373

Query: 308  KFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQ 367
            + + E   E   L    +  +   A  +E+ +  R Q  E+  K+ + +      ++ +Q
Sbjct: 2374 R-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432

Query: 368  RCDLAAHLGLRAPSPRDSDAESDA-----GKKESDGEESRLPQPKRE--GPVGGESDSEE 420
              ++      R  S  D++   +A      +KE   +E++L Q K E    V  E   +E
Sbjct: 2433 TLEIQ-----RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487

Query: 421  MFEKTSGFGSGKPSEASEPCPTELLKAR------EDSEYLVTLKHEAQRLERTVERLITD 474
                   F S K S        E  KA+      ++      L+ E QR ++ +E+    
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2547

Query: 475  TDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQ--QEPQLLGTINAKMKAFKKELQAFLEQ 532
              + + +A  R      G   + EE Q    Q  Q+ +LL   N ++   +++LQ  LE+
Sbjct: 2548 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL---REQLQ-LLEE 2603

Query: 533  VNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPAR 592
             +R          L  S    ++  + ++  P G    + GP  ++  +   +       
Sbjct: 2604 QHRAA--------LAHSEEVTASQVAATKTLPNGRDALD-GPAAEAEPEHSFDGLRRKVS 2654

Query: 593  GDERESLRLRAARELHRRADGDT 615
                +   + +A EL R A G T
Sbjct: 2655 AQRLQEAGILSAEELQRLAQGHT 2677



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 204/988 (20%), Positives = 374/988 (37%), Gaps = 196/988 (19%)

Query: 36   RLRKAEQKSLKVAETGQVDGELIRSLEQDL---KVAKDVSVRLHHELKTVEEKRAKAEDE 92
            RL    +K L + E       L   LE  L   +  + +S     +LKT+       +  
Sbjct: 1042 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1101

Query: 93   NETLR---QQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQL 149
             E LR   +Q+ E +     L  ELE  K S  K R+  E   ++ TF+      LR +L
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEA--QQPTFDA-----LRDEL 1153

Query: 150  QFAKEEAFLMRKKMAK----LGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREA 205
            + A+E    ++++  +    + R ++ + Q L++++++    D              R+ 
Sbjct: 1154 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD-------------VRQR 1200

Query: 206  ELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFG 265
            EL+            LGR++         L A ++D R +QE+          I   P  
Sbjct: 1201 ELEQ-----------LGRQLRYYRESADPLGAWLQDARRRQEQ----------IQAMPLA 1239

Query: 266  DSLESSTELR----------RHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPR 315
            DS     +LR          RH + VEE     ++ I+ I+D+  QL     K + EP  
Sbjct: 1240 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV--TYKAQLEPVA 1297

Query: 316  EPGWLGEGASPGAGGGAPLQE--ELKSARLQISELSGKVLKL------QHENHALLSNIQ 367
             P    +     +G  + +QE  +L++   +++ L+ + +K       + E    L+  Q
Sbjct: 1298 SP---AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1354

Query: 368  RCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSG 427
            R +    L        + +A  +  ++ ++       Q +RE     +   EE+  +   
Sbjct: 1355 RAEERERLA-------EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1407

Query: 428  FGSGKPSEASEPCPTELLKAREDSEYLVTLK-HEAQRLERTVERLITDTDSFLHDAGLRG 486
                +  + S     EL + R+ SE  +  K  +A+  ER+  R+    +  +    L+ 
Sbjct: 1408 AVDAQQQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRI----EEEIRVVRLQ- 1460

Query: 487  GAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHL 546
                    L+  E Q  G + E Q L     + +A K++ Q   E++ R           
Sbjct: 1461 --------LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR----------- 1501

Query: 547  TESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDER-----ESLRL 601
                        V  +S      ++   +L SR+K + E     AR  +R     E LRL
Sbjct: 1502 -----------QVQDES---QRKRQAEVELASRVKAEAE----AAREKQRALQALEELRL 1543

Query: 602  RAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEET 661
            + A E  RR                   LR   V   + V +     Q    A L Q + 
Sbjct: 1544 Q-AEEAERR-------------------LRQAEVERARQVQVALETAQRSAEAEL-QSKR 1582

Query: 662  ETFTNKIHKME----EEHLYALRWKELEMHSLALQNTLHERTWSD-EKNLMQQELRSLKQ 716
             +F  K  ++E    EEH+   + +E E    A Q    ER   + E+ L + +L++ + 
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLRE-EAERRAQQQAEAERAREEAERELERWQLKANEA 1641

Query: 717  NIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSD 776
                  ++LR   +   Q K + +   E  + E      R G+   Q   Q +  + + +
Sbjct: 1642 ------LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1695

Query: 777  RGCGFPVGEHSPHSRVQIGDHSLRLQT-ADRGQPHKQVVENQ------------QLFSAF 823
            +     + E +   R+      +RL+   ++G+  +Q++E +            Q     
Sbjct: 1696 K--QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753

Query: 824  KALLEDFRAEL----------REDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKT 873
            +A L   RAE+           E+ R+     +Q    +A    E A    RL  L E+ 
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1813

Query: 874  ENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELL--- 930
            + +  +L     ++   + ER + +KL A   +  +    +I   EK    E++  L   
Sbjct: 1814 KRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872

Query: 931  DRLDRDRQEWE--RQKKEFLWRIEQLQK 956
            +   R R E +  + K +   R+ QL+K
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLRK 1900



 Score = 38.9 bits (89), Expect = 0.040
 Identities = 87/408 (21%), Positives = 169/408 (41%), Gaps = 56/408 (13%)

Query: 577  QSRLKEQLE-WQLGPARGDERESLRLRAAREL-HRRADGDTGSHGLGGQTCFSLELRGPP 634
            + R+ + LE WQ   A+ D R+    +  R+L + R   D     L        +++  P
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 635  VLPEQSVSIEELQGQ-LVQAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQN 693
            +   Q+V  +  Q Q L++    H E+ E    +  +  ++++ A++  EL++ +   Q 
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVE----ECQRFAKQYINAIKDYELQLVTYKAQL 1293

Query: 694  TLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRW-----------LLKHWRQGKQMEEEG 742
               E   S  K   + +++S  +++   YV LR             +K   +  +  EE 
Sbjct: 1294 ---EPVASPAK---KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE 1347

Query: 743  EEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQ 802
            E   E +  E   RL E  V+   +      ++           +   + ++ +  +R +
Sbjct: 1348 ERLAEQQRAEERERLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1405

Query: 803  TA--DRGQPHKQVVEN-QQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEW 859
             A  D  Q  + + E  QQL  + +A ++    +    ER+RLR+++           E 
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE-----------EI 1454

Query: 860  AVLKCRLEQLEEK---TENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIH 916
             V++ +LE  E +    E +L  L + AE   A K++ +   +           LR Q+ 
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE----------RLRRQVQ 1504

Query: 917  HSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQ--LQKENSPRR 962
               +   + +VEL  R+ +   E  R+K+  L  +E+  LQ E + RR
Sbjct: 1505 DESQRKRQAEVELASRV-KAEAEAAREKQRALQALEELRLQAEEAERR 1551


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 228/1154 (19%), Positives = 435/1154 (37%), Gaps = 146/1154 (12%)

Query: 9    LEEDV----YQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETG-----QVDGELIR 59
            +EE++     QL+   R+   A    + L+ R  +AE +  +  E       QV  E  R
Sbjct: 1418 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477

Query: 60   SLEQDLKVAKDVSVRLH------HELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNE 113
              + ++++A  V             L+ +EE R +AE+    LRQ  +E     Q     
Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1537

Query: 114  LERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDEL 173
             +R  E+ L  +S R  + EK    +    +    +   +EEA    ++ A+  R ++E 
Sbjct: 1538 AQRSAEAEL--QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1595

Query: 174  EQELQKYKSLYG----------DVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGR 223
            E+EL++++              +V       +A       EAE + R +   EE  +  R
Sbjct: 1596 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1655

Query: 224  KIVELEVE----------NRGLKAEMEDMR-------GQQEREGPGRDHAPSIPTSPFGD 266
            ++ E E+E           + L AE E +R       G+Q+R+    + A          
Sbjct: 1656 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL--QREAAA 1713

Query: 267  SLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASP 326
            + +   EL   L  V  E E+L  S +  E+ +R  T E SK + E   E G   E A  
Sbjct: 1714 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRS-TSEKSKQRLE--AEAGRFRELAEE 1770

Query: 327  GAGGGAPLQEELKSARLQISELSGK----VLKLQHENHALLSNIQRCDLAAHLGLRAPSP 382
             A   A L EE K  R    E + +      ++  E  A +    R    A + L     
Sbjct: 1771 AARLRA-LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL----- 1824

Query: 383  RDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPT 442
            ++ +AE++  ++ ++ +E+   +   E     ++D EE   +       +          
Sbjct: 1825 KEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1883

Query: 443  ELLKAREDSEYLVTLKHEAQR-------LERTVERLITDTDSFLHDAGLRGGAPLPGPGL 495
             L + R+  E ++ LK   ++       LE  + R+ ++ +  L               L
Sbjct: 1884 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1943

Query: 496  QGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLST 555
              EEE+   + +E ++  ++ A+ +A  ++ +A LE+V R+   +     L E +   S 
Sbjct: 1944 AAEEERRRREAEE-RVQKSLAAEEEA-ARQRKAALEEVERLKAKVEEARRLRERAEQESA 2001

Query: 556  ---------------VTSVSRDSPIGNLGKELGPDLQSR--LKEQLEWQLGPAR--GDER 596
                               +    +    +EL   LQ    + +QL  +   AR   +E 
Sbjct: 2002 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2061

Query: 597  ESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQ-----GQLV 651
            E  R++A RE  +       +  L        + R       + +  E  Q      Q  
Sbjct: 2062 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2121

Query: 652  QAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQQEL 711
            QAA   ++  +    K  K  E+ L      E E+ +L LQ  L E     +KNL+ +EL
Sbjct: 2122 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ--LEET--DHQKNLLDEEL 2177

Query: 712  RSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL-GELGVQG------ 764
            + LK              +  RQ  Q+EE  E F+     E LS+L   +  +       
Sbjct: 2178 QRLKAE----------ATEAARQRSQVEE--ELFSVRVQMEELSKLKARIEAENRALILR 2225

Query: 765  ---------GHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVE 815
                       +A+     ++      V         Q+ +  L  Q A   +  K+ ++
Sbjct: 2226 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2285

Query: 816  NQQLFSAFKALLE--DFRAELREDERARLRLQQQYASDKAAWDVEW---AVLKCRLEQLE 870
              Q  +  KA  E    + EL +++  RL+  ++  + + A + +     +   R  QLE
Sbjct: 2286 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2345

Query: 871  EKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELL 930
               E +  +L  +  S+   + E +  +           ++  ++H +E    +EKV L+
Sbjct: 2346 MSAEAERLKLRVAEMSRAQARAEEDAQR-----FRKQAEEIGEKLHRTELA-TQEKVTLV 2399

Query: 931  DRLDRDRQEWERQKKEFLWRIEQLQKENSPRRGGSFLCDQKDGNVRPFPHQGSLRMPRPV 990
              L+  RQ+ +   +     I +L++E    +  + L   K   ++    +  L+  + +
Sbjct: 2400 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2459

Query: 991  AMWPCADADSIPFEDRPLSKLKESDRCSASENLYLDALSLDDEPEEPPAHRPEREFRNRL 1050
                 ++ DS          L + +R    E   L+ L  D+  +       ++  + ++
Sbjct: 2460 QQSFLSEKDS----------LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2509

Query: 1051 PEEEENHKGNLQRA 1064
             +E +    +++ A
Sbjct: 2510 EQERQRLVASMEEA 2523



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 176/928 (18%), Positives = 340/928 (36%), Gaps = 93/928 (10%)

Query: 25   RANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLH-HELKTVE 83
            +A +  + LQ R+++   +  + A   Q     I+   Q L+ + +  ++    + +  E
Sbjct: 1353 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1412

Query: 84   EKRAKAEDENETLRQQMIEVEISKQALQNELE----RLKESSLKRRSTREMYKEKKTFNQ 139
              R + E+E   +R Q+   E  +   + EL+    R +E+  ++R  +E  +  +   Q
Sbjct: 1413 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1472

Query: 140  DDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGP 199
            D+S   R     A+ E     K  A+  REK    Q L++ +    + +  L   E    
Sbjct: 1473 DESQRKR----QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1528

Query: 200  PSTR----------EAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQERE 249
               +          EAEL+ +     E+   L R + E  V    L+ E E    QQ   
Sbjct: 1529 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1588

Query: 250  GPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKF 309
               R+              E+  EL R  Q    EA  LR    E+         E  K 
Sbjct: 1589 ERARE--------------EAERELER-WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1633

Query: 310  KFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRC 369
            K E  RE    G+            ++EL+  R      + + L  + E   L +  ++ 
Sbjct: 1634 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1693

Query: 370  DLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFG 429
            +    L     +    +A +   K++    E    + + E  +  ++ +EE    TS   
Sbjct: 1694 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1753

Query: 430  -------SGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDA 482
                   +G+  E +E        A E        + +A R     ER++ +  + + +A
Sbjct: 1754 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1813

Query: 483  -GLRGGAPLPGPGLQGEEEQ----GEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIG 537
              L+  A +     + E E+     E +  + + L    A+ KA   +++  L Q+ +  
Sbjct: 1814 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERLAQLRKAS 1870

Query: 538  DGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERE 597
            D       L      +       R      L  +   +  +  K +LE +LG  R +  +
Sbjct: 1871 DS-----ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1925

Query: 598  SLR------LRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSV--SIEELQGQ 649
            +LR      L AAR+    A+ +        +   SL          ++    +E L+ +
Sbjct: 1926 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1985

Query: 650  LVQAARLH-----------QEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTL-HE 697
            + +A RL            Q   E    ++   E+ H +A++ KE E     LQ TL  E
Sbjct: 1986 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-----LQQTLQQE 2040

Query: 698  RTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL 757
            ++  D+     +  R   +      V+     +   Q ++  EE E   +    +  +R 
Sbjct: 2041 QSVLDQLRGEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARA 2097

Query: 758  GELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQ 817
                     + +     + R       E +   + Q  D  +        Q  +Q  + +
Sbjct: 2098 QAQAAAEKLRKEAEQEAARRA----QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2153

Query: 818  QLFSAFKALLE--DFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTEN 875
            Q  +  +  LE  D +  L ++E  RL+ +   A+ + +  VE  +   R+ Q+EE ++ 
Sbjct: 2154 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS-QVEEELFSVRV-QMEELSKL 2211

Query: 876  KLGELGSSAESKGALKKEREVHQKLLAD 903
            K       AE++  + ++++  Q+ L +
Sbjct: 2212 K---ARIEAENRALILRDKDNTQRFLQE 2236



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 137/623 (21%), Positives = 247/623 (39%), Gaps = 75/623 (12%)

Query: 11   EDVYQLQELRRELDRANKNCRILQYRLRK-AEQKSLKVAETGQVDGELIRSLEQDLKVAK 69
            E+  +L++   E  +A    +    +LRK AEQ++ + A+  Q       +L Q  K A 
Sbjct: 2080 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA------ALRQ--KQAA 2131

Query: 70   DVSVRLHHEL--KTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRST 127
            D  +  H +   +T+ +K A+ E E  TLR Q+ E +  K  L  EL+RLK  +      
Sbjct: 2132 DAEMEKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA------ 2184

Query: 128  REMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDV 187
                         ++A  R Q++   EE F +R +M +L + K  +E E +    +  D 
Sbjct: 2185 ------------TEAARQRSQVE---EELFSVRVQMEELSKLKARIEAENRAL--ILRDK 2227

Query: 188  DSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQE 247
            D+     +       + AE   RL +  +EA  L +   E   + R L  +M   + Q  
Sbjct: 2228 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2287

Query: 248  REGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELS 307
            +E         +         E + E  R LQ  E++ ++ ++   E +   R L  E  
Sbjct: 2288 QEATRLKAEAEL----LQQQKELAQEQARRLQ--EDKEQMAQQLAEETQGFQRTLEAERQ 2341

Query: 308  KFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQ 367
            + + E   E   L    +  +   A  +E+ +  R Q  E+  K+ + +      ++ +Q
Sbjct: 2342 R-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2400

Query: 368  RCDLAAHLGLRAPSPRDSDAESDA-----GKKESDGEESRLPQPKRE--GPVGGESDSEE 420
              ++      R  S  D++   +A      +KE   +E++L Q K E    V  E   +E
Sbjct: 2401 TLEIQ-----RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2455

Query: 421  MFEKTSGFGSGKPSEASEPCPTELLKAR------EDSEYLVTLKHEAQRLERTVERLITD 474
                   F S K S        E  KA+      ++      L+ E QR ++ +E+    
Sbjct: 2456 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2515

Query: 475  TDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQ--QEPQLLGTINAKMKAFKKELQAFLEQ 532
              + + +A  R      G   + EE Q    Q  Q+ +LL   N ++   +++LQ  LE+
Sbjct: 2516 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL---REQLQ-LLEE 2571

Query: 533  VNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPAR 592
             +R          L  S    ++  + ++  P G    + GP  ++  +   +       
Sbjct: 2572 QHRAA--------LAHSEEVTASQVAATKTLPNGRDALD-GPAAEAEPEHSFDGLRRKVS 2622

Query: 593  GDERESLRLRAARELHRRADGDT 615
                +   + +A EL R A G T
Sbjct: 2623 AQRLQEAGILSAEELQRLAQGHT 2645



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 204/988 (20%), Positives = 374/988 (37%), Gaps = 196/988 (19%)

Query: 36   RLRKAEQKSLKVAETGQVDGELIRSLEQDL---KVAKDVSVRLHHELKTVEEKRAKAEDE 92
            RL    +K L + E       L   LE  L   +  + +S     +LKT+       +  
Sbjct: 1010 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1069

Query: 93   NETLR---QQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQL 149
             E LR   +Q+ E +     L  ELE  K S  K R+  E   ++ TF+      LR +L
Sbjct: 1070 EEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEA--QQPTFDA-----LRDEL 1121

Query: 150  QFAKEEAFLMRKKMAK----LGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREA 205
            + A+E    ++++  +    + R ++ + Q L++++++    D              R+ 
Sbjct: 1122 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD-------------VRQR 1168

Query: 206  ELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFG 265
            EL+            LGR++         L A ++D R +QE+          I   P  
Sbjct: 1169 ELEQ-----------LGRQLRYYRESADPLGAWLQDARRRQEQ----------IQAMPLA 1207

Query: 266  DSLESSTELR----------RHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPR 315
            DS     +LR          RH + VEE     ++ I+ I+D+  QL     K + EP  
Sbjct: 1208 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV--TYKAQLEPVA 1265

Query: 316  EPGWLGEGASPGAGGGAPLQE--ELKSARLQISELSGKVLKL------QHENHALLSNIQ 367
             P    +     +G  + +QE  +L++   +++ L+ + +K       + E    L+  Q
Sbjct: 1266 SP---AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1322

Query: 368  RCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSG 427
            R +    L        + +A  +  ++ ++       Q +RE     +   EE+  +   
Sbjct: 1323 RAEERERLA-------EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1375

Query: 428  FGSGKPSEASEPCPTELLKAREDSEYLVTLK-HEAQRLERTVERLITDTDSFLHDAGLRG 486
                +  + S     EL + R+ SE  +  K  +A+  ER+  R+    +  +    L+ 
Sbjct: 1376 AVDAQQQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRI----EEEIRVVRLQ- 1428

Query: 487  GAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHL 546
                    L+  E Q  G + E Q L     + +A K++ Q   E++ R           
Sbjct: 1429 --------LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR----------- 1469

Query: 547  TESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDER-----ESLRL 601
                        V  +S      ++   +L SR+K + E     AR  +R     E LRL
Sbjct: 1470 -----------QVQDES---QRKRQAEVELASRVKAEAE----AAREKQRALQALEELRL 1511

Query: 602  RAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEET 661
            + A E  RR                   LR   V   + V +     Q    A L Q + 
Sbjct: 1512 Q-AEEAERR-------------------LRQAEVERARQVQVALETAQRSAEAEL-QSKR 1550

Query: 662  ETFTNKIHKME----EEHLYALRWKELEMHSLALQNTLHERTWSD-EKNLMQQELRSLKQ 716
             +F  K  ++E    EEH+   + +E E    A Q    ER   + E+ L + +L++ + 
Sbjct: 1551 ASFAEKTAQLERSLQEEHVAVAQLRE-EAERRAQQQAEAERAREEAERELERWQLKANEA 1609

Query: 717  NIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSD 776
                  ++LR   +   Q K + +   E  + E      R G+   Q   Q +  + + +
Sbjct: 1610 ------LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1663

Query: 777  RGCGFPVGEHSPHSRVQIGDHSLRLQT-ADRGQPHKQVVENQ------------QLFSAF 823
            +     + E +   R+      +RL+   ++G+  +Q++E +            Q     
Sbjct: 1664 K--QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721

Query: 824  KALLEDFRAEL----------REDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKT 873
            +A L   RAE+           E+ R+     +Q    +A    E A    RL  L E+ 
Sbjct: 1722 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1781

Query: 874  ENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELL--- 930
            + +  +L     ++   + ER + +KL A   +  +    +I   EK    E++  L   
Sbjct: 1782 KRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1840

Query: 931  DRLDRDRQEWE--RQKKEFLWRIEQLQK 956
            +   R R E +  + K +   R+ QL+K
Sbjct: 1841 EAFQRRRLEEQAAQHKADIEERLAQLRK 1868



 Score = 38.9 bits (89), Expect = 0.040
 Identities = 87/408 (21%), Positives = 169/408 (41%), Gaps = 56/408 (13%)

Query: 577  QSRLKEQLE-WQLGPARGDERESLRLRAAREL-HRRADGDTGSHGLGGQTCFSLELRGPP 634
            + R+ + LE WQ   A+ D R+    +  R+L + R   D     L        +++  P
Sbjct: 1146 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1205

Query: 635  VLPEQSVSIEELQGQ-LVQAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQN 693
            +   Q+V  +  Q Q L++    H E+ E    +  +  ++++ A++  EL++ +   Q 
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVE----ECQRFAKQYINAIKDYELQLVTYKAQL 1261

Query: 694  TLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRW-----------LLKHWRQGKQMEEEG 742
               E   S  K   + +++S  +++   YV LR             +K   +  +  EE 
Sbjct: 1262 ---EPVASPAK---KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE 1315

Query: 743  EEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQ 802
            E   E +  E   RL E  V+   +      ++           +   + ++ +  +R +
Sbjct: 1316 ERLAEQQRAEERERLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1373

Query: 803  TA--DRGQPHKQVVEN-QQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEW 859
             A  D  Q  + + E  QQL  + +A ++    +    ER+RLR+++           E 
Sbjct: 1374 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE-----------EI 1422

Query: 860  AVLKCRLEQLEEK---TENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIH 916
             V++ +LE  E +    E +L  L + AE   A K++ +   +           LR Q+ 
Sbjct: 1423 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE----------RLRRQVQ 1472

Query: 917  HSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQ--LQKENSPRR 962
               +   + +VEL  R+ +   E  R+K+  L  +E+  LQ E + RR
Sbjct: 1473 DESQRKRQAEVELASRV-KAEAEAAREKQRALQALEELRLQAEEAERR 1519


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 228/1154 (19%), Positives = 435/1154 (37%), Gaps = 146/1154 (12%)

Query: 9    LEEDV----YQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETG-----QVDGELIR 59
            +EE++     QL+   R+   A    + L+ R  +AE +  +  E       QV  E  R
Sbjct: 1587 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646

Query: 60   SLEQDLKVAKDVSVRLH------HELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNE 113
              + ++++A  V             L+ +EE R +AE+    LRQ  +E     Q     
Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1706

Query: 114  LERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDEL 173
             +R  E+ L  +S R  + EK    +    +    +   +EEA    ++ A+  R ++E 
Sbjct: 1707 AQRSAEAEL--QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1764

Query: 174  EQELQKYKSLYG----------DVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGR 223
            E+EL++++              +V       +A       EAE + R +   EE  +  R
Sbjct: 1765 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1824

Query: 224  KIVELEVE----------NRGLKAEMEDMR-------GQQEREGPGRDHAPSIPTSPFGD 266
            ++ E E+E           + L AE E +R       G+Q+R+    + A          
Sbjct: 1825 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL--QREAAA 1882

Query: 267  SLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASP 326
            + +   EL   L  V  E E+L  S +  E+ +R  T E SK + E   E G   E A  
Sbjct: 1883 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRS-TSEKSKQRLE--AEAGRFRELAEE 1939

Query: 327  GAGGGAPLQEELKSARLQISELSGK----VLKLQHENHALLSNIQRCDLAAHLGLRAPSP 382
             A   A L EE K  R    E + +      ++  E  A +    R    A + L     
Sbjct: 1940 AARLRA-LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL----- 1993

Query: 383  RDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPT 442
            ++ +AE++  ++ ++ +E+   +   E     ++D EE   +       +          
Sbjct: 1994 KEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 2052

Query: 443  ELLKAREDSEYLVTLKHEAQR-------LERTVERLITDTDSFLHDAGLRGGAPLPGPGL 495
             L + R+  E ++ LK   ++       LE  + R+ ++ +  L               L
Sbjct: 2053 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2112

Query: 496  QGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLST 555
              EEE+   + +E ++  ++ A+ +A  ++ +A LE+V R+   +     L E +   S 
Sbjct: 2113 AAEEERRRREAEE-RVQKSLAAEEEA-ARQRKAALEEVERLKAKVEEARRLRERAEQESA 2170

Query: 556  ---------------VTSVSRDSPIGNLGKELGPDLQSR--LKEQLEWQLGPAR--GDER 596
                               +    +    +EL   LQ    + +QL  +   AR   +E 
Sbjct: 2171 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2230

Query: 597  ESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQ-----GQLV 651
            E  R++A RE  +       +  L        + R       + +  E  Q      Q  
Sbjct: 2231 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2290

Query: 652  QAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQQEL 711
            QAA   ++  +    K  K  E+ L      E E+ +L LQ  L E     +KNL+ +EL
Sbjct: 2291 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ--LEET--DHQKNLLDEEL 2346

Query: 712  RSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL-GELGVQG------ 764
            + LK              +  RQ  Q+EE  E F+     E LS+L   +  +       
Sbjct: 2347 QRLKAE----------ATEAARQRSQVEE--ELFSVRVQMEELSKLKARIEAENRALILR 2394

Query: 765  ---------GHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVE 815
                       +A+     ++      V         Q+ +  L  Q A   +  K+ ++
Sbjct: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2454

Query: 816  NQQLFSAFKALLE--DFRAELREDERARLRLQQQYASDKAAWDVEW---AVLKCRLEQLE 870
              Q  +  KA  E    + EL +++  RL+  ++  + + A + +     +   R  QLE
Sbjct: 2455 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514

Query: 871  EKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELL 930
               E +  +L  +  S+   + E +  +           ++  ++H +E    +EKV L+
Sbjct: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQR-----FRKQAEEIGEKLHRTELA-TQEKVTLV 2568

Query: 931  DRLDRDRQEWERQKKEFLWRIEQLQKENSPRRGGSFLCDQKDGNVRPFPHQGSLRMPRPV 990
              L+  RQ+ +   +     I +L++E    +  + L   K   ++    +  L+  + +
Sbjct: 2569 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2628

Query: 991  AMWPCADADSIPFEDRPLSKLKESDRCSASENLYLDALSLDDEPEEPPAHRPEREFRNRL 1050
                 ++ DS          L + +R    E   L+ L  D+  +       ++  + ++
Sbjct: 2629 QQSFLSEKDS----------LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2678

Query: 1051 PEEEENHKGNLQRA 1064
             +E +    +++ A
Sbjct: 2679 EQERQRLVASMEEA 2692



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 176/928 (18%), Positives = 340/928 (36%), Gaps = 93/928 (10%)

Query: 25   RANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLH-HELKTVE 83
            +A +  + LQ R+++   +  + A   Q     I+   Q L+ + +  ++    + +  E
Sbjct: 1522 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1581

Query: 84   EKRAKAEDENETLRQQMIEVEISKQALQNELE----RLKESSLKRRSTREMYKEKKTFNQ 139
              R + E+E   +R Q+   E  +   + EL+    R +E+  ++R  +E  +  +   Q
Sbjct: 1582 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1641

Query: 140  DDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGP 199
            D+S   R     A+ E     K  A+  REK    Q L++ +    + +  L   E    
Sbjct: 1642 DESQRKR----QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1697

Query: 200  PSTR----------EAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQERE 249
               +          EAEL+ +     E+   L R + E  V    L+ E E    QQ   
Sbjct: 1698 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1757

Query: 250  GPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKF 309
               R+              E+  EL R  Q    EA  LR    E+         E  K 
Sbjct: 1758 ERARE--------------EAERELER-WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1802

Query: 310  KFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRC 369
            K E  RE    G+            ++EL+  R      + + L  + E   L +  ++ 
Sbjct: 1803 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1862

Query: 370  DLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFG 429
            +    L     +    +A +   K++    E    + + E  +  ++ +EE    TS   
Sbjct: 1863 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1922

Query: 430  -------SGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDA 482
                   +G+  E +E        A E        + +A R     ER++ +  + + +A
Sbjct: 1923 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1982

Query: 483  -GLRGGAPLPGPGLQGEEEQ----GEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIG 537
              L+  A +     + E E+     E +  + + L    A+ KA   +++  L Q+ +  
Sbjct: 1983 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERLAQLRKAS 2039

Query: 538  DGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERE 597
            D       L      +       R      L  +   +  +  K +LE +LG  R +  +
Sbjct: 2040 DS-----ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 2094

Query: 598  SLR------LRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSV--SIEELQGQ 649
            +LR      L AAR+    A+ +        +   SL          ++    +E L+ +
Sbjct: 2095 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154

Query: 650  LVQAARLH-----------QEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTL-HE 697
            + +A RL            Q   E    ++   E+ H +A++ KE E     LQ TL  E
Sbjct: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-----LQQTLQQE 2209

Query: 698  RTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL 757
            ++  D+     +  R   +      V+     +   Q ++  EE E   +    +  +R 
Sbjct: 2210 QSVLDQLRGEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARA 2266

Query: 758  GELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQ 817
                     + +     + R       E +   + Q  D  +        Q  +Q  + +
Sbjct: 2267 QAQAAAEKLRKEAEQEAARRA----QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2322

Query: 818  QLFSAFKALLE--DFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTEN 875
            Q  +  +  LE  D +  L ++E  RL+ +   A+ + +  VE  +   R+ Q+EE ++ 
Sbjct: 2323 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS-QVEEELFSVRV-QMEELSKL 2380

Query: 876  KLGELGSSAESKGALKKEREVHQKLLAD 903
            K       AE++  + ++++  Q+ L +
Sbjct: 2381 K---ARIEAENRALILRDKDNTQRFLQE 2405



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 137/623 (21%), Positives = 247/623 (39%), Gaps = 75/623 (12%)

Query: 11   EDVYQLQELRRELDRANKNCRILQYRLRK-AEQKSLKVAETGQVDGELIRSLEQDLKVAK 69
            E+  +L++   E  +A    +    +LRK AEQ++ + A+  Q       +L Q  K A 
Sbjct: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA------ALRQ--KQAA 2300

Query: 70   DVSVRLHHEL--KTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRST 127
            D  +  H +   +T+ +K A+ E E  TLR Q+ E +  K  L  EL+RLK  +      
Sbjct: 2301 DAEMEKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA------ 2353

Query: 128  REMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDV 187
                         ++A  R Q++   EE F +R +M +L + K  +E E +    +  D 
Sbjct: 2354 ------------TEAARQRSQVE---EELFSVRVQMEELSKLKARIEAENRAL--ILRDK 2396

Query: 188  DSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQE 247
            D+     +       + AE   RL +  +EA  L +   E   + R L  +M   + Q  
Sbjct: 2397 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2456

Query: 248  REGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELS 307
            +E         +         E + E  R LQ  E++ ++ ++   E +   R L  E  
Sbjct: 2457 QEATRLKAEAEL----LQQQKELAQEQARRLQ--EDKEQMAQQLAEETQGFQRTLEAERQ 2510

Query: 308  KFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQ 367
            + + E   E   L    +  +   A  +E+ +  R Q  E+  K+ + +      ++ +Q
Sbjct: 2511 R-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2569

Query: 368  RCDLAAHLGLRAPSPRDSDAESDA-----GKKESDGEESRLPQPKRE--GPVGGESDSEE 420
              ++      R  S  D++   +A      +KE   +E++L Q K E    V  E   +E
Sbjct: 2570 TLEIQ-----RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2624

Query: 421  MFEKTSGFGSGKPSEASEPCPTELLKAR------EDSEYLVTLKHEAQRLERTVERLITD 474
                   F S K S        E  KA+      ++      L+ E QR ++ +E+    
Sbjct: 2625 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2684

Query: 475  TDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQ--QEPQLLGTINAKMKAFKKELQAFLEQ 532
              + + +A  R      G   + EE Q    Q  Q+ +LL   N ++   +++LQ  LE+
Sbjct: 2685 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL---REQLQ-LLEE 2740

Query: 533  VNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPAR 592
             +R          L  S    ++  + ++  P G    + GP  ++  +   +       
Sbjct: 2741 QHRAA--------LAHSEEVTASQVAATKTLPNGRDALD-GPAAEAEPEHSFDGLRRKVS 2791

Query: 593  GDERESLRLRAARELHRRADGDT 615
                +   + +A EL R A G T
Sbjct: 2792 AQRLQEAGILSAEELQRLAQGHT 2814



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 204/988 (20%), Positives = 374/988 (37%), Gaps = 196/988 (19%)

Query: 36   RLRKAEQKSLKVAETGQVDGELIRSLEQDL---KVAKDVSVRLHHELKTVEEKRAKAEDE 92
            RL    +K L + E       L   LE  L   +  + +S     +LKT+       +  
Sbjct: 1179 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1238

Query: 93   NETLR---QQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQL 149
             E LR   +Q+ E +     L  ELE  K S  K R+  E   ++ TF+      LR +L
Sbjct: 1239 EEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEA--QQPTFDA-----LRDEL 1290

Query: 150  QFAKEEAFLMRKKMAK----LGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREA 205
            + A+E    ++++  +    + R ++ + Q L++++++    D              R+ 
Sbjct: 1291 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD-------------VRQR 1337

Query: 206  ELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFG 265
            EL+            LGR++         L A ++D R +QE+          I   P  
Sbjct: 1338 ELEQ-----------LGRQLRYYRESADPLGAWLQDARRRQEQ----------IQAMPLA 1376

Query: 266  DSLESSTELR----------RHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPR 315
            DS     +LR          RH + VEE     ++ I+ I+D+  QL     K + EP  
Sbjct: 1377 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV--TYKAQLEPVA 1434

Query: 316  EPGWLGEGASPGAGGGAPLQE--ELKSARLQISELSGKVLKL------QHENHALLSNIQ 367
             P    +     +G  + +QE  +L++   +++ L+ + +K       + E    L+  Q
Sbjct: 1435 SP---AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1491

Query: 368  RCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSG 427
            R +    L        + +A  +  ++ ++       Q +RE     +   EE+  +   
Sbjct: 1492 RAEERERLA-------EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1544

Query: 428  FGSGKPSEASEPCPTELLKAREDSEYLVTLK-HEAQRLERTVERLITDTDSFLHDAGLRG 486
                +  + S     EL + R+ SE  +  K  +A+  ER+  R+    +  +    L+ 
Sbjct: 1545 AVDAQQQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRI----EEEIRVVRLQ- 1597

Query: 487  GAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHL 546
                    L+  E Q  G + E Q L     + +A K++ Q   E++ R           
Sbjct: 1598 --------LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR----------- 1638

Query: 547  TESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDER-----ESLRL 601
                        V  +S      ++   +L SR+K + E     AR  +R     E LRL
Sbjct: 1639 -----------QVQDES---QRKRQAEVELASRVKAEAE----AAREKQRALQALEELRL 1680

Query: 602  RAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEET 661
            + A E  RR                   LR   V   + V +     Q    A L Q + 
Sbjct: 1681 Q-AEEAERR-------------------LRQAEVERARQVQVALETAQRSAEAEL-QSKR 1719

Query: 662  ETFTNKIHKME----EEHLYALRWKELEMHSLALQNTLHERTWSD-EKNLMQQELRSLKQ 716
             +F  K  ++E    EEH+   + +E E    A Q    ER   + E+ L + +L++ + 
Sbjct: 1720 ASFAEKTAQLERSLQEEHVAVAQLRE-EAERRAQQQAEAERAREEAERELERWQLKANEA 1778

Query: 717  NIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSD 776
                  ++LR   +   Q K + +   E  + E      R G+   Q   Q +  + + +
Sbjct: 1779 ------LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1832

Query: 777  RGCGFPVGEHSPHSRVQIGDHSLRLQT-ADRGQPHKQVVENQ------------QLFSAF 823
            +     + E +   R+      +RL+   ++G+  +Q++E +            Q     
Sbjct: 1833 K--QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1890

Query: 824  KALLEDFRAEL----------REDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKT 873
            +A L   RAE+           E+ R+     +Q    +A    E A    RL  L E+ 
Sbjct: 1891 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1950

Query: 874  ENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELL--- 930
            + +  +L     ++   + ER + +KL A   +  +    +I   EK    E++  L   
Sbjct: 1951 KRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 2009

Query: 931  DRLDRDRQEWE--RQKKEFLWRIEQLQK 956
            +   R R E +  + K +   R+ QL+K
Sbjct: 2010 EAFQRRRLEEQAAQHKADIEERLAQLRK 2037



 Score = 38.9 bits (89), Expect = 0.040
 Identities = 87/408 (21%), Positives = 169/408 (41%), Gaps = 56/408 (13%)

Query: 577  QSRLKEQLE-WQLGPARGDERESLRLRAAREL-HRRADGDTGSHGLGGQTCFSLELRGPP 634
            + R+ + LE WQ   A+ D R+    +  R+L + R   D     L        +++  P
Sbjct: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374

Query: 635  VLPEQSVSIEELQGQ-LVQAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQN 693
            +   Q+V  +  Q Q L++    H E+ E    +  +  ++++ A++  EL++ +   Q 
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVE----ECQRFAKQYINAIKDYELQLVTYKAQL 1430

Query: 694  TLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRW-----------LLKHWRQGKQMEEEG 742
               E   S  K   + +++S  +++   YV LR             +K   +  +  EE 
Sbjct: 1431 ---EPVASPAK---KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE 1484

Query: 743  EEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQ 802
            E   E +  E   RL E  V+   +      ++           +   + ++ +  +R +
Sbjct: 1485 ERLAEQQRAEERERLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1542

Query: 803  TA--DRGQPHKQVVEN-QQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEW 859
             A  D  Q  + + E  QQL  + +A ++    +    ER+RLR+++           E 
Sbjct: 1543 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE-----------EI 1591

Query: 860  AVLKCRLEQLEEK---TENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIH 916
             V++ +LE  E +    E +L  L + AE   A K++ +   +           LR Q+ 
Sbjct: 1592 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE----------RLRRQVQ 1641

Query: 917  HSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQ--LQKENSPRR 962
               +   + +VEL  R+ +   E  R+K+  L  +E+  LQ E + RR
Sbjct: 1642 DESQRKRQAEVELASRV-KAEAEAAREKQRALQALEELRLQAEEAERR 1688


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 228/1154 (19%), Positives = 435/1154 (37%), Gaps = 146/1154 (12%)

Query: 9    LEEDV----YQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETG-----QVDGELIR 59
            +EE++     QL+   R+   A    + L+ R  +AE +  +  E       QV  E  R
Sbjct: 1428 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487

Query: 60   SLEQDLKVAKDVSVRLH------HELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNE 113
              + ++++A  V             L+ +EE R +AE+    LRQ  +E     Q     
Sbjct: 1488 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1547

Query: 114  LERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDEL 173
             +R  E+ L  +S R  + EK    +    +    +   +EEA    ++ A+  R ++E 
Sbjct: 1548 AQRSAEAEL--QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1605

Query: 174  EQELQKYKSLYG----------DVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGR 223
            E+EL++++              +V       +A       EAE + R +   EE  +  R
Sbjct: 1606 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1665

Query: 224  KIVELEVE----------NRGLKAEMEDMR-------GQQEREGPGRDHAPSIPTSPFGD 266
            ++ E E+E           + L AE E +R       G+Q+R+    + A          
Sbjct: 1666 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL--QREAAA 1723

Query: 267  SLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASP 326
            + +   EL   L  V  E E+L  S +  E+ +R  T E SK + E   E G   E A  
Sbjct: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRS-TSEKSKQRLE--AEAGRFRELAEE 1780

Query: 327  GAGGGAPLQEELKSARLQISELSGK----VLKLQHENHALLSNIQRCDLAAHLGLRAPSP 382
             A   A L EE K  R    E + +      ++  E  A +    R    A + L     
Sbjct: 1781 AARLRA-LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL----- 1834

Query: 383  RDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPT 442
            ++ +AE++  ++ ++ +E+   +   E     ++D EE   +       +          
Sbjct: 1835 KEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1893

Query: 443  ELLKAREDSEYLVTLKHEAQR-------LERTVERLITDTDSFLHDAGLRGGAPLPGPGL 495
             L + R+  E ++ LK   ++       LE  + R+ ++ +  L               L
Sbjct: 1894 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1953

Query: 496  QGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLST 555
              EEE+   + +E ++  ++ A+ +A  ++ +A LE+V R+   +     L E +   S 
Sbjct: 1954 AAEEERRRREAEE-RVQKSLAAEEEA-ARQRKAALEEVERLKAKVEEARRLRERAEQESA 2011

Query: 556  ---------------VTSVSRDSPIGNLGKELGPDLQSR--LKEQLEWQLGPAR--GDER 596
                               +    +    +EL   LQ    + +QL  +   AR   +E 
Sbjct: 2012 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2071

Query: 597  ESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQ-----GQLV 651
            E  R++A RE  +       +  L        + R       + +  E  Q      Q  
Sbjct: 2072 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2131

Query: 652  QAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQQEL 711
            QAA   ++  +    K  K  E+ L      E E+ +L LQ  L E     +KNL+ +EL
Sbjct: 2132 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ--LEET--DHQKNLLDEEL 2187

Query: 712  RSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL-GELGVQG------ 764
            + LK              +  RQ  Q+EE  E F+     E LS+L   +  +       
Sbjct: 2188 QRLKAE----------ATEAARQRSQVEE--ELFSVRVQMEELSKLKARIEAENRALILR 2235

Query: 765  ---------GHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVE 815
                       +A+     ++      V         Q+ +  L  Q A   +  K+ ++
Sbjct: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2295

Query: 816  NQQLFSAFKALLE--DFRAELREDERARLRLQQQYASDKAAWDVEW---AVLKCRLEQLE 870
              Q  +  KA  E    + EL +++  RL+  ++  + + A + +     +   R  QLE
Sbjct: 2296 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2355

Query: 871  EKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELL 930
               E +  +L  +  S+   + E +  +           ++  ++H +E    +EKV L+
Sbjct: 2356 MSAEAERLKLRVAEMSRAQARAEEDAQR-----FRKQAEEIGEKLHRTELA-TQEKVTLV 2409

Query: 931  DRLDRDRQEWERQKKEFLWRIEQLQKENSPRRGGSFLCDQKDGNVRPFPHQGSLRMPRPV 990
              L+  RQ+ +   +     I +L++E    +  + L   K   ++    +  L+  + +
Sbjct: 2410 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2469

Query: 991  AMWPCADADSIPFEDRPLSKLKESDRCSASENLYLDALSLDDEPEEPPAHRPEREFRNRL 1050
                 ++ DS          L + +R    E   L+ L  D+  +       ++  + ++
Sbjct: 2470 QQSFLSEKDS----------LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2519

Query: 1051 PEEEENHKGNLQRA 1064
             +E +    +++ A
Sbjct: 2520 EQERQRLVASMEEA 2533



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 176/928 (18%), Positives = 340/928 (36%), Gaps = 93/928 (10%)

Query: 25   RANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLH-HELKTVE 83
            +A +  + LQ R+++   +  + A   Q     I+   Q L+ + +  ++    + +  E
Sbjct: 1363 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1422

Query: 84   EKRAKAEDENETLRQQMIEVEISKQALQNELE----RLKESSLKRRSTREMYKEKKTFNQ 139
              R + E+E   +R Q+   E  +   + EL+    R +E+  ++R  +E  +  +   Q
Sbjct: 1423 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1482

Query: 140  DDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGP 199
            D+S   R     A+ E     K  A+  REK    Q L++ +    + +  L   E    
Sbjct: 1483 DESQRKR----QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1538

Query: 200  PSTR----------EAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQERE 249
               +          EAEL+ +     E+   L R + E  V    L+ E E    QQ   
Sbjct: 1539 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1598

Query: 250  GPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKF 309
               R+              E+  EL R  Q    EA  LR    E+         E  K 
Sbjct: 1599 ERARE--------------EAERELER-WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1643

Query: 310  KFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRC 369
            K E  RE    G+            ++EL+  R      + + L  + E   L +  ++ 
Sbjct: 1644 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1703

Query: 370  DLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFG 429
            +    L     +    +A +   K++    E    + + E  +  ++ +EE    TS   
Sbjct: 1704 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1763

Query: 430  -------SGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDA 482
                   +G+  E +E        A E        + +A R     ER++ +  + + +A
Sbjct: 1764 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1823

Query: 483  -GLRGGAPLPGPGLQGEEEQ----GEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIG 537
              L+  A +     + E E+     E +  + + L    A+ KA   +++  L Q+ +  
Sbjct: 1824 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERLAQLRKAS 1880

Query: 538  DGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERE 597
            D       L      +       R      L  +   +  +  K +LE +LG  R +  +
Sbjct: 1881 DS-----ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1935

Query: 598  SLR------LRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSV--SIEELQGQ 649
            +LR      L AAR+    A+ +        +   SL          ++    +E L+ +
Sbjct: 1936 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995

Query: 650  LVQAARLH-----------QEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTL-HE 697
            + +A RL            Q   E    ++   E+ H +A++ KE E     LQ TL  E
Sbjct: 1996 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-----LQQTLQQE 2050

Query: 698  RTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL 757
            ++  D+     +  R   +      V+     +   Q ++  EE E   +    +  +R 
Sbjct: 2051 QSVLDQLRGEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARA 2107

Query: 758  GELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQ 817
                     + +     + R       E +   + Q  D  +        Q  +Q  + +
Sbjct: 2108 QAQAAAEKLRKEAEQEAARRA----QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2163

Query: 818  QLFSAFKALLE--DFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTEN 875
            Q  +  +  LE  D +  L ++E  RL+ +   A+ + +  VE  +   R+ Q+EE ++ 
Sbjct: 2164 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS-QVEEELFSVRV-QMEELSKL 2221

Query: 876  KLGELGSSAESKGALKKEREVHQKLLAD 903
            K       AE++  + ++++  Q+ L +
Sbjct: 2222 K---ARIEAENRALILRDKDNTQRFLQE 2246



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 137/623 (21%), Positives = 247/623 (39%), Gaps = 75/623 (12%)

Query: 11   EDVYQLQELRRELDRANKNCRILQYRLRK-AEQKSLKVAETGQVDGELIRSLEQDLKVAK 69
            E+  +L++   E  +A    +    +LRK AEQ++ + A+  Q       +L Q  K A 
Sbjct: 2090 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA------ALRQ--KQAA 2141

Query: 70   DVSVRLHHEL--KTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRST 127
            D  +  H +   +T+ +K A+ E E  TLR Q+ E +  K  L  EL+RLK  +      
Sbjct: 2142 DAEMEKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA------ 2194

Query: 128  REMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDV 187
                         ++A  R Q++   EE F +R +M +L + K  +E E +    +  D 
Sbjct: 2195 ------------TEAARQRSQVE---EELFSVRVQMEELSKLKARIEAENRAL--ILRDK 2237

Query: 188  DSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQE 247
            D+     +       + AE   RL +  +EA  L +   E   + R L  +M   + Q  
Sbjct: 2238 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2297

Query: 248  REGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELS 307
            +E         +         E + E  R LQ  E++ ++ ++   E +   R L  E  
Sbjct: 2298 QEATRLKAEAEL----LQQQKELAQEQARRLQ--EDKEQMAQQLAEETQGFQRTLEAERQ 2351

Query: 308  KFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQ 367
            + + E   E   L    +  +   A  +E+ +  R Q  E+  K+ + +      ++ +Q
Sbjct: 2352 R-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2410

Query: 368  RCDLAAHLGLRAPSPRDSDAESDA-----GKKESDGEESRLPQPKRE--GPVGGESDSEE 420
              ++      R  S  D++   +A      +KE   +E++L Q K E    V  E   +E
Sbjct: 2411 TLEIQ-----RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2465

Query: 421  MFEKTSGFGSGKPSEASEPCPTELLKAR------EDSEYLVTLKHEAQRLERTVERLITD 474
                   F S K S        E  KA+      ++      L+ E QR ++ +E+    
Sbjct: 2466 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2525

Query: 475  TDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQ--QEPQLLGTINAKMKAFKKELQAFLEQ 532
              + + +A  R      G   + EE Q    Q  Q+ +LL   N ++   +++LQ  LE+
Sbjct: 2526 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL---REQLQ-LLEE 2581

Query: 533  VNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPAR 592
             +R          L  S    ++  + ++  P G    + GP  ++  +   +       
Sbjct: 2582 QHRAA--------LAHSEEVTASQVAATKTLPNGRDALD-GPAAEAEPEHSFDGLRRKVS 2632

Query: 593  GDERESLRLRAARELHRRADGDT 615
                +   + +A EL R A G T
Sbjct: 2633 AQRLQEAGILSAEELQRLAQGHT 2655



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 204/988 (20%), Positives = 374/988 (37%), Gaps = 196/988 (19%)

Query: 36   RLRKAEQKSLKVAETGQVDGELIRSLEQDL---KVAKDVSVRLHHELKTVEEKRAKAEDE 92
            RL    +K L + E       L   LE  L   +  + +S     +LKT+       +  
Sbjct: 1020 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1079

Query: 93   NETLR---QQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQL 149
             E LR   +Q+ E +     L  ELE  K S  K R+  E   ++ TF+      LR +L
Sbjct: 1080 EEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEA--QQPTFDA-----LRDEL 1131

Query: 150  QFAKEEAFLMRKKMAK----LGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREA 205
            + A+E    ++++  +    + R ++ + Q L++++++    D              R+ 
Sbjct: 1132 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD-------------VRQR 1178

Query: 206  ELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFG 265
            EL+            LGR++         L A ++D R +QE+          I   P  
Sbjct: 1179 ELEQ-----------LGRQLRYYRESADPLGAWLQDARRRQEQ----------IQAMPLA 1217

Query: 266  DSLESSTELR----------RHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPR 315
            DS     +LR          RH + VEE     ++ I+ I+D+  QL     K + EP  
Sbjct: 1218 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV--TYKAQLEPVA 1275

Query: 316  EPGWLGEGASPGAGGGAPLQE--ELKSARLQISELSGKVLKL------QHENHALLSNIQ 367
             P    +     +G  + +QE  +L++   +++ L+ + +K       + E    L+  Q
Sbjct: 1276 SP---AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1332

Query: 368  RCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSG 427
            R +    L        + +A  +  ++ ++       Q +RE     +   EE+  +   
Sbjct: 1333 RAEERERLA-------EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1385

Query: 428  FGSGKPSEASEPCPTELLKAREDSEYLVTLK-HEAQRLERTVERLITDTDSFLHDAGLRG 486
                +  + S     EL + R+ SE  +  K  +A+  ER+  R+    +  +    L+ 
Sbjct: 1386 AVDAQQQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRI----EEEIRVVRLQ- 1438

Query: 487  GAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHL 546
                    L+  E Q  G + E Q L     + +A K++ Q   E++ R           
Sbjct: 1439 --------LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR----------- 1479

Query: 547  TESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDER-----ESLRL 601
                        V  +S      ++   +L SR+K + E     AR  +R     E LRL
Sbjct: 1480 -----------QVQDES---QRKRQAEVELASRVKAEAE----AAREKQRALQALEELRL 1521

Query: 602  RAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEET 661
            + A E  RR                   LR   V   + V +     Q    A L Q + 
Sbjct: 1522 Q-AEEAERR-------------------LRQAEVERARQVQVALETAQRSAEAEL-QSKR 1560

Query: 662  ETFTNKIHKME----EEHLYALRWKELEMHSLALQNTLHERTWSD-EKNLMQQELRSLKQ 716
             +F  K  ++E    EEH+   + +E E    A Q    ER   + E+ L + +L++ + 
Sbjct: 1561 ASFAEKTAQLERSLQEEHVAVAQLRE-EAERRAQQQAEAERAREEAERELERWQLKANEA 1619

Query: 717  NIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSD 776
                  ++LR   +   Q K + +   E  + E      R G+   Q   Q +  + + +
Sbjct: 1620 ------LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1673

Query: 777  RGCGFPVGEHSPHSRVQIGDHSLRLQT-ADRGQPHKQVVENQ------------QLFSAF 823
            +     + E +   R+      +RL+   ++G+  +Q++E +            Q     
Sbjct: 1674 K--QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1731

Query: 824  KALLEDFRAEL----------REDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKT 873
            +A L   RAE+           E+ R+     +Q    +A    E A    RL  L E+ 
Sbjct: 1732 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1791

Query: 874  ENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELL--- 930
            + +  +L     ++   + ER + +KL A   +  +    +I   EK    E++  L   
Sbjct: 1792 KRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1850

Query: 931  DRLDRDRQEWE--RQKKEFLWRIEQLQK 956
            +   R R E +  + K +   R+ QL+K
Sbjct: 1851 EAFQRRRLEEQAAQHKADIEERLAQLRK 1878



 Score = 38.9 bits (89), Expect = 0.040
 Identities = 87/408 (21%), Positives = 169/408 (41%), Gaps = 56/408 (13%)

Query: 577  QSRLKEQLE-WQLGPARGDERESLRLRAAREL-HRRADGDTGSHGLGGQTCFSLELRGPP 634
            + R+ + LE WQ   A+ D R+    +  R+L + R   D     L        +++  P
Sbjct: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215

Query: 635  VLPEQSVSIEELQGQ-LVQAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQN 693
            +   Q+V  +  Q Q L++    H E+ E    +  +  ++++ A++  EL++ +   Q 
Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVE----ECQRFAKQYINAIKDYELQLVTYKAQL 1271

Query: 694  TLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRW-----------LLKHWRQGKQMEEEG 742
               E   S  K   + +++S  +++   YV LR             +K   +  +  EE 
Sbjct: 1272 ---EPVASPAK---KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE 1325

Query: 743  EEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQ 802
            E   E +  E   RL E  V+   +      ++           +   + ++ +  +R +
Sbjct: 1326 ERLAEQQRAEERERLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1383

Query: 803  TA--DRGQPHKQVVEN-QQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEW 859
             A  D  Q  + + E  QQL  + +A ++    +    ER+RLR+++           E 
Sbjct: 1384 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE-----------EI 1432

Query: 860  AVLKCRLEQLEEK---TENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIH 916
             V++ +LE  E +    E +L  L + AE   A K++ +   +           LR Q+ 
Sbjct: 1433 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE----------RLRRQVQ 1482

Query: 917  HSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQ--LQKENSPRR 962
               +   + +VEL  R+ +   E  R+K+  L  +E+  LQ E + RR
Sbjct: 1483 DESQRKRQAEVELASRV-KAEAEAAREKQRALQALEELRLQAEEAERR 1529


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 228/1154 (19%), Positives = 435/1154 (37%), Gaps = 146/1154 (12%)

Query: 9    LEEDV----YQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETG-----QVDGELIR 59
            +EE++     QL+   R+   A    + L+ R  +AE +  +  E       QV  E  R
Sbjct: 1436 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1495

Query: 60   SLEQDLKVAKDVSVRLH------HELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNE 113
              + ++++A  V             L+ +EE R +AE+    LRQ  +E     Q     
Sbjct: 1496 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1555

Query: 114  LERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDEL 173
             +R  E+ L  +S R  + EK    +    +    +   +EEA    ++ A+  R ++E 
Sbjct: 1556 AQRSAEAEL--QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1613

Query: 174  EQELQKYKSLYG----------DVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGR 223
            E+EL++++              +V       +A       EAE + R +   EE  +  R
Sbjct: 1614 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1673

Query: 224  KIVELEVE----------NRGLKAEMEDMR-------GQQEREGPGRDHAPSIPTSPFGD 266
            ++ E E+E           + L AE E +R       G+Q+R+    + A          
Sbjct: 1674 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL--QREAAA 1731

Query: 267  SLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASP 326
            + +   EL   L  V  E E+L  S +  E+ +R  T E SK + E   E G   E A  
Sbjct: 1732 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRS-TSEKSKQRLE--AEAGRFRELAEE 1788

Query: 327  GAGGGAPLQEELKSARLQISELSGK----VLKLQHENHALLSNIQRCDLAAHLGLRAPSP 382
             A   A L EE K  R    E + +      ++  E  A +    R    A + L     
Sbjct: 1789 AARLRA-LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL----- 1842

Query: 383  RDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPT 442
            ++ +AE++  ++ ++ +E+   +   E     ++D EE   +       +          
Sbjct: 1843 KEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1901

Query: 443  ELLKAREDSEYLVTLKHEAQR-------LERTVERLITDTDSFLHDAGLRGGAPLPGPGL 495
             L + R+  E ++ LK   ++       LE  + R+ ++ +  L               L
Sbjct: 1902 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1961

Query: 496  QGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLST 555
              EEE+   + +E ++  ++ A+ +A  ++ +A LE+V R+   +     L E +   S 
Sbjct: 1962 AAEEERRRREAEE-RVQKSLAAEEEA-ARQRKAALEEVERLKAKVEEARRLRERAEQESA 2019

Query: 556  ---------------VTSVSRDSPIGNLGKELGPDLQSR--LKEQLEWQLGPAR--GDER 596
                               +    +    +EL   LQ    + +QL  +   AR   +E 
Sbjct: 2020 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2079

Query: 597  ESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQ-----GQLV 651
            E  R++A RE  +       +  L        + R       + +  E  Q      Q  
Sbjct: 2080 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2139

Query: 652  QAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQQEL 711
            QAA   ++  +    K  K  E+ L      E E+ +L LQ  L E     +KNL+ +EL
Sbjct: 2140 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ--LEET--DHQKNLLDEEL 2195

Query: 712  RSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL-GELGVQG------ 764
            + LK              +  RQ  Q+EE  E F+     E LS+L   +  +       
Sbjct: 2196 QRLKAE----------ATEAARQRSQVEE--ELFSVRVQMEELSKLKARIEAENRALILR 2243

Query: 765  ---------GHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVE 815
                       +A+     ++      V         Q+ +  L  Q A   +  K+ ++
Sbjct: 2244 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2303

Query: 816  NQQLFSAFKALLE--DFRAELREDERARLRLQQQYASDKAAWDVEW---AVLKCRLEQLE 870
              Q  +  KA  E    + EL +++  RL+  ++  + + A + +     +   R  QLE
Sbjct: 2304 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2363

Query: 871  EKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELL 930
               E +  +L  +  S+   + E +  +           ++  ++H +E    +EKV L+
Sbjct: 2364 MSAEAERLKLRVAEMSRAQARAEEDAQR-----FRKQAEEIGEKLHRTELA-TQEKVTLV 2417

Query: 931  DRLDRDRQEWERQKKEFLWRIEQLQKENSPRRGGSFLCDQKDGNVRPFPHQGSLRMPRPV 990
              L+  RQ+ +   +     I +L++E    +  + L   K   ++    +  L+  + +
Sbjct: 2418 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2477

Query: 991  AMWPCADADSIPFEDRPLSKLKESDRCSASENLYLDALSLDDEPEEPPAHRPEREFRNRL 1050
                 ++ DS          L + +R    E   L+ L  D+  +       ++  + ++
Sbjct: 2478 QQSFLSEKDS----------LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2527

Query: 1051 PEEEENHKGNLQRA 1064
             +E +    +++ A
Sbjct: 2528 EQERQRLVASMEEA 2541



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 176/928 (18%), Positives = 340/928 (36%), Gaps = 93/928 (10%)

Query: 25   RANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLH-HELKTVE 83
            +A +  + LQ R+++   +  + A   Q     I+   Q L+ + +  ++    + +  E
Sbjct: 1371 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1430

Query: 84   EKRAKAEDENETLRQQMIEVEISKQALQNELE----RLKESSLKRRSTREMYKEKKTFNQ 139
              R + E+E   +R Q+   E  +   + EL+    R +E+  ++R  +E  +  +   Q
Sbjct: 1431 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1490

Query: 140  DDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGP 199
            D+S   R     A+ E     K  A+  REK    Q L++ +    + +  L   E    
Sbjct: 1491 DESQRKR----QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1546

Query: 200  PSTR----------EAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQERE 249
               +          EAEL+ +     E+   L R + E  V    L+ E E    QQ   
Sbjct: 1547 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1606

Query: 250  GPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKF 309
               R+              E+  EL R  Q    EA  LR    E+         E  K 
Sbjct: 1607 ERARE--------------EAERELER-WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1651

Query: 310  KFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRC 369
            K E  RE    G+            ++EL+  R      + + L  + E   L +  ++ 
Sbjct: 1652 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1711

Query: 370  DLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFG 429
            +    L     +    +A +   K++    E    + + E  +  ++ +EE    TS   
Sbjct: 1712 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1771

Query: 430  -------SGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDA 482
                   +G+  E +E        A E        + +A R     ER++ +  + + +A
Sbjct: 1772 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1831

Query: 483  -GLRGGAPLPGPGLQGEEEQ----GEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIG 537
              L+  A +     + E E+     E +  + + L    A+ KA   +++  L Q+ +  
Sbjct: 1832 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERLAQLRKAS 1888

Query: 538  DGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERE 597
            D       L      +       R      L  +   +  +  K +LE +LG  R +  +
Sbjct: 1889 DS-----ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1943

Query: 598  SLR------LRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSV--SIEELQGQ 649
            +LR      L AAR+    A+ +        +   SL          ++    +E L+ +
Sbjct: 1944 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2003

Query: 650  LVQAARLH-----------QEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTL-HE 697
            + +A RL            Q   E    ++   E+ H +A++ KE E     LQ TL  E
Sbjct: 2004 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-----LQQTLQQE 2058

Query: 698  RTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL 757
            ++  D+     +  R   +      V+     +   Q ++  EE E   +    +  +R 
Sbjct: 2059 QSVLDQLRGEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARA 2115

Query: 758  GELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQ 817
                     + +     + R       E +   + Q  D  +        Q  +Q  + +
Sbjct: 2116 QAQAAAEKLRKEAEQEAARRA----QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2171

Query: 818  QLFSAFKALLE--DFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTEN 875
            Q  +  +  LE  D +  L ++E  RL+ +   A+ + +  VE  +   R+ Q+EE ++ 
Sbjct: 2172 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS-QVEEELFSVRV-QMEELSKL 2229

Query: 876  KLGELGSSAESKGALKKEREVHQKLLAD 903
            K       AE++  + ++++  Q+ L +
Sbjct: 2230 K---ARIEAENRALILRDKDNTQRFLQE 2254



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 137/623 (21%), Positives = 247/623 (39%), Gaps = 75/623 (12%)

Query: 11   EDVYQLQELRRELDRANKNCRILQYRLRK-AEQKSLKVAETGQVDGELIRSLEQDLKVAK 69
            E+  +L++   E  +A    +    +LRK AEQ++ + A+  Q       +L Q  K A 
Sbjct: 2098 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA------ALRQ--KQAA 2149

Query: 70   DVSVRLHHEL--KTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRST 127
            D  +  H +   +T+ +K A+ E E  TLR Q+ E +  K  L  EL+RLK  +      
Sbjct: 2150 DAEMEKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA------ 2202

Query: 128  REMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDV 187
                         ++A  R Q++   EE F +R +M +L + K  +E E +    +  D 
Sbjct: 2203 ------------TEAARQRSQVE---EELFSVRVQMEELSKLKARIEAENRAL--ILRDK 2245

Query: 188  DSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQE 247
            D+     +       + AE   RL +  +EA  L +   E   + R L  +M   + Q  
Sbjct: 2246 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2305

Query: 248  REGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELS 307
            +E         +         E + E  R LQ  E++ ++ ++   E +   R L  E  
Sbjct: 2306 QEATRLKAEAEL----LQQQKELAQEQARRLQ--EDKEQMAQQLAEETQGFQRTLEAERQ 2359

Query: 308  KFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQ 367
            + + E   E   L    +  +   A  +E+ +  R Q  E+  K+ + +      ++ +Q
Sbjct: 2360 R-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2418

Query: 368  RCDLAAHLGLRAPSPRDSDAESDA-----GKKESDGEESRLPQPKRE--GPVGGESDSEE 420
              ++      R  S  D++   +A      +KE   +E++L Q K E    V  E   +E
Sbjct: 2419 TLEIQ-----RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2473

Query: 421  MFEKTSGFGSGKPSEASEPCPTELLKAR------EDSEYLVTLKHEAQRLERTVERLITD 474
                   F S K S        E  KA+      ++      L+ E QR ++ +E+    
Sbjct: 2474 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2533

Query: 475  TDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQ--QEPQLLGTINAKMKAFKKELQAFLEQ 532
              + + +A  R      G   + EE Q    Q  Q+ +LL   N ++   +++LQ  LE+
Sbjct: 2534 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL---REQLQ-LLEE 2589

Query: 533  VNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPAR 592
             +R          L  S    ++  + ++  P G    + GP  ++  +   +       
Sbjct: 2590 QHRAA--------LAHSEEVTASQVAATKTLPNGRDALD-GPAAEAEPEHSFDGLRRKVS 2640

Query: 593  GDERESLRLRAARELHRRADGDT 615
                +   + +A EL R A G T
Sbjct: 2641 AQRLQEAGILSAEELQRLAQGHT 2663



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 204/988 (20%), Positives = 374/988 (37%), Gaps = 196/988 (19%)

Query: 36   RLRKAEQKSLKVAETGQVDGELIRSLEQDL---KVAKDVSVRLHHELKTVEEKRAKAEDE 92
            RL    +K L + E       L   LE  L   +  + +S     +LKT+       +  
Sbjct: 1028 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1087

Query: 93   NETLR---QQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQL 149
             E LR   +Q+ E +     L  ELE  K S  K R+  E   ++ TF+      LR +L
Sbjct: 1088 EEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEA--QQPTFDA-----LRDEL 1139

Query: 150  QFAKEEAFLMRKKMAK----LGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREA 205
            + A+E    ++++  +    + R ++ + Q L++++++    D              R+ 
Sbjct: 1140 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD-------------VRQR 1186

Query: 206  ELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFG 265
            EL+            LGR++         L A ++D R +QE+          I   P  
Sbjct: 1187 ELEQ-----------LGRQLRYYRESADPLGAWLQDARRRQEQ----------IQAMPLA 1225

Query: 266  DSLESSTELR----------RHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPR 315
            DS     +LR          RH + VEE     ++ I+ I+D+  QL     K + EP  
Sbjct: 1226 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV--TYKAQLEPVA 1283

Query: 316  EPGWLGEGASPGAGGGAPLQE--ELKSARLQISELSGKVLKL------QHENHALLSNIQ 367
             P    +     +G  + +QE  +L++   +++ L+ + +K       + E    L+  Q
Sbjct: 1284 SP---AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1340

Query: 368  RCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSG 427
            R +    L        + +A  +  ++ ++       Q +RE     +   EE+  +   
Sbjct: 1341 RAEERERLA-------EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1393

Query: 428  FGSGKPSEASEPCPTELLKAREDSEYLVTLK-HEAQRLERTVERLITDTDSFLHDAGLRG 486
                +  + S     EL + R+ SE  +  K  +A+  ER+  R+    +  +    L+ 
Sbjct: 1394 AVDAQQQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRI----EEEIRVVRLQ- 1446

Query: 487  GAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHL 546
                    L+  E Q  G + E Q L     + +A K++ Q   E++ R           
Sbjct: 1447 --------LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR----------- 1487

Query: 547  TESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDER-----ESLRL 601
                        V  +S      ++   +L SR+K + E     AR  +R     E LRL
Sbjct: 1488 -----------QVQDES---QRKRQAEVELASRVKAEAE----AAREKQRALQALEELRL 1529

Query: 602  RAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEET 661
            + A E  RR                   LR   V   + V +     Q    A L Q + 
Sbjct: 1530 Q-AEEAERR-------------------LRQAEVERARQVQVALETAQRSAEAEL-QSKR 1568

Query: 662  ETFTNKIHKME----EEHLYALRWKELEMHSLALQNTLHERTWSD-EKNLMQQELRSLKQ 716
             +F  K  ++E    EEH+   + +E E    A Q    ER   + E+ L + +L++ + 
Sbjct: 1569 ASFAEKTAQLERSLQEEHVAVAQLRE-EAERRAQQQAEAERAREEAERELERWQLKANEA 1627

Query: 717  NIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSD 776
                  ++LR   +   Q K + +   E  + E      R G+   Q   Q +  + + +
Sbjct: 1628 ------LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1681

Query: 777  RGCGFPVGEHSPHSRVQIGDHSLRLQT-ADRGQPHKQVVENQ------------QLFSAF 823
            +     + E +   R+      +RL+   ++G+  +Q++E +            Q     
Sbjct: 1682 K--QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1739

Query: 824  KALLEDFRAEL----------REDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKT 873
            +A L   RAE+           E+ R+     +Q    +A    E A    RL  L E+ 
Sbjct: 1740 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1799

Query: 874  ENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELL--- 930
            + +  +L     ++   + ER + +KL A   +  +    +I   EK    E++  L   
Sbjct: 1800 KRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1858

Query: 931  DRLDRDRQEWE--RQKKEFLWRIEQLQK 956
            +   R R E +  + K +   R+ QL+K
Sbjct: 1859 EAFQRRRLEEQAAQHKADIEERLAQLRK 1886



 Score = 38.9 bits (89), Expect = 0.040
 Identities = 87/408 (21%), Positives = 169/408 (41%), Gaps = 56/408 (13%)

Query: 577  QSRLKEQLE-WQLGPARGDERESLRLRAAREL-HRRADGDTGSHGLGGQTCFSLELRGPP 634
            + R+ + LE WQ   A+ D R+    +  R+L + R   D     L        +++  P
Sbjct: 1164 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1223

Query: 635  VLPEQSVSIEELQGQ-LVQAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQN 693
            +   Q+V  +  Q Q L++    H E+ E    +  +  ++++ A++  EL++ +   Q 
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVE----ECQRFAKQYINAIKDYELQLVTYKAQL 1279

Query: 694  TLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRW-----------LLKHWRQGKQMEEEG 742
               E   S  K   + +++S  +++   YV LR             +K   +  +  EE 
Sbjct: 1280 ---EPVASPAK---KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE 1333

Query: 743  EEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQ 802
            E   E +  E   RL E  V+   +      ++           +   + ++ +  +R +
Sbjct: 1334 ERLAEQQRAEERERLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1391

Query: 803  TA--DRGQPHKQVVEN-QQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEW 859
             A  D  Q  + + E  QQL  + +A ++    +    ER+RLR+++           E 
Sbjct: 1392 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE-----------EI 1440

Query: 860  AVLKCRLEQLEEK---TENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIH 916
             V++ +LE  E +    E +L  L + AE   A K++ +   +           LR Q+ 
Sbjct: 1441 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE----------RLRRQVQ 1490

Query: 917  HSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQ--LQKENSPRR 962
               +   + +VEL  R+ +   E  R+K+  L  +E+  LQ E + RR
Sbjct: 1491 DESQRKRQAEVELASRV-KAEAEAAREKQRALQALEELRLQAEEAERR 1537


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 228/1154 (19%), Positives = 435/1154 (37%), Gaps = 146/1154 (12%)

Query: 9    LEEDV----YQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETG-----QVDGELIR 59
            +EE++     QL+   R+   A    + L+ R  +AE +  +  E       QV  E  R
Sbjct: 1477 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536

Query: 60   SLEQDLKVAKDVSVRLH------HELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNE 113
              + ++++A  V             L+ +EE R +AE+    LRQ  +E     Q     
Sbjct: 1537 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1596

Query: 114  LERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDEL 173
             +R  E+ L  +S R  + EK    +    +    +   +EEA    ++ A+  R ++E 
Sbjct: 1597 AQRSAEAEL--QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1654

Query: 174  EQELQKYKSLYG----------DVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGR 223
            E+EL++++              +V       +A       EAE + R +   EE  +  R
Sbjct: 1655 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1714

Query: 224  KIVELEVE----------NRGLKAEMEDMR-------GQQEREGPGRDHAPSIPTSPFGD 266
            ++ E E+E           + L AE E +R       G+Q+R+    + A          
Sbjct: 1715 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL--QREAAA 1772

Query: 267  SLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASP 326
            + +   EL   L  V  E E+L  S +  E+ +R  T E SK + E   E G   E A  
Sbjct: 1773 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRS-TSEKSKQRLE--AEAGRFRELAEE 1829

Query: 327  GAGGGAPLQEELKSARLQISELSGK----VLKLQHENHALLSNIQRCDLAAHLGLRAPSP 382
             A   A L EE K  R    E + +      ++  E  A +    R    A + L     
Sbjct: 1830 AARLRA-LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL----- 1883

Query: 383  RDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPT 442
            ++ +AE++  ++ ++ +E+   +   E     ++D EE   +       +          
Sbjct: 1884 KEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1942

Query: 443  ELLKAREDSEYLVTLKHEAQR-------LERTVERLITDTDSFLHDAGLRGGAPLPGPGL 495
             L + R+  E ++ LK   ++       LE  + R+ ++ +  L               L
Sbjct: 1943 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2002

Query: 496  QGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLST 555
              EEE+   + +E ++  ++ A+ +A  ++ +A LE+V R+   +     L E +   S 
Sbjct: 2003 AAEEERRRREAEE-RVQKSLAAEEEA-ARQRKAALEEVERLKAKVEEARRLRERAEQESA 2060

Query: 556  ---------------VTSVSRDSPIGNLGKELGPDLQSR--LKEQLEWQLGPAR--GDER 596
                               +    +    +EL   LQ    + +QL  +   AR   +E 
Sbjct: 2061 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2120

Query: 597  ESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQ-----GQLV 651
            E  R++A RE  +       +  L        + R       + +  E  Q      Q  
Sbjct: 2121 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2180

Query: 652  QAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQQEL 711
            QAA   ++  +    K  K  E+ L      E E+ +L LQ  L E     +KNL+ +EL
Sbjct: 2181 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ--LEET--DHQKNLLDEEL 2236

Query: 712  RSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL-GELGVQG------ 764
            + LK              +  RQ  Q+EE  E F+     E LS+L   +  +       
Sbjct: 2237 QRLKAE----------ATEAARQRSQVEE--ELFSVRVQMEELSKLKARIEAENRALILR 2284

Query: 765  ---------GHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVE 815
                       +A+     ++      V         Q+ +  L  Q A   +  K+ ++
Sbjct: 2285 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2344

Query: 816  NQQLFSAFKALLE--DFRAELREDERARLRLQQQYASDKAAWDVEW---AVLKCRLEQLE 870
              Q  +  KA  E    + EL +++  RL+  ++  + + A + +     +   R  QLE
Sbjct: 2345 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2404

Query: 871  EKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELL 930
               E +  +L  +  S+   + E +  +           ++  ++H +E    +EKV L+
Sbjct: 2405 MSAEAERLKLRVAEMSRAQARAEEDAQR-----FRKQAEEIGEKLHRTELA-TQEKVTLV 2458

Query: 931  DRLDRDRQEWERQKKEFLWRIEQLQKENSPRRGGSFLCDQKDGNVRPFPHQGSLRMPRPV 990
              L+  RQ+ +   +     I +L++E    +  + L   K   ++    +  L+  + +
Sbjct: 2459 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2518

Query: 991  AMWPCADADSIPFEDRPLSKLKESDRCSASENLYLDALSLDDEPEEPPAHRPEREFRNRL 1050
                 ++ DS          L + +R    E   L+ L  D+  +       ++  + ++
Sbjct: 2519 QQSFLSEKDS----------LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2568

Query: 1051 PEEEENHKGNLQRA 1064
             +E +    +++ A
Sbjct: 2569 EQERQRLVASMEEA 2582



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 176/928 (18%), Positives = 340/928 (36%), Gaps = 93/928 (10%)

Query: 25   RANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLH-HELKTVE 83
            +A +  + LQ R+++   +  + A   Q     I+   Q L+ + +  ++    + +  E
Sbjct: 1412 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1471

Query: 84   EKRAKAEDENETLRQQMIEVEISKQALQNELE----RLKESSLKRRSTREMYKEKKTFNQ 139
              R + E+E   +R Q+   E  +   + EL+    R +E+  ++R  +E  +  +   Q
Sbjct: 1472 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1531

Query: 140  DDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGP 199
            D+S   R     A+ E     K  A+  REK    Q L++ +    + +  L   E    
Sbjct: 1532 DESQRKR----QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1587

Query: 200  PSTR----------EAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQERE 249
               +          EAEL+ +     E+   L R + E  V    L+ E E    QQ   
Sbjct: 1588 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1647

Query: 250  GPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKF 309
               R+              E+  EL R  Q    EA  LR    E+         E  K 
Sbjct: 1648 ERARE--------------EAERELER-WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1692

Query: 310  KFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRC 369
            K E  RE    G+            ++EL+  R      + + L  + E   L +  ++ 
Sbjct: 1693 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1752

Query: 370  DLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFG 429
            +    L     +    +A +   K++    E    + + E  +  ++ +EE    TS   
Sbjct: 1753 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1812

Query: 430  -------SGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDA 482
                   +G+  E +E        A E        + +A R     ER++ +  + + +A
Sbjct: 1813 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1872

Query: 483  -GLRGGAPLPGPGLQGEEEQ----GEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIG 537
              L+  A +     + E E+     E +  + + L    A+ KA   +++  L Q+ +  
Sbjct: 1873 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERLAQLRKAS 1929

Query: 538  DGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERE 597
            D       L      +       R      L  +   +  +  K +LE +LG  R +  +
Sbjct: 1930 DS-----ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1984

Query: 598  SLR------LRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSV--SIEELQGQ 649
            +LR      L AAR+    A+ +        +   SL          ++    +E L+ +
Sbjct: 1985 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2044

Query: 650  LVQAARLH-----------QEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTL-HE 697
            + +A RL            Q   E    ++   E+ H +A++ KE E     LQ TL  E
Sbjct: 2045 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-----LQQTLQQE 2099

Query: 698  RTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL 757
            ++  D+     +  R   +      V+     +   Q ++  EE E   +    +  +R 
Sbjct: 2100 QSVLDQLRGEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARA 2156

Query: 758  GELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQ 817
                     + +     + R       E +   + Q  D  +        Q  +Q  + +
Sbjct: 2157 QAQAAAEKLRKEAEQEAARRA----QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2212

Query: 818  QLFSAFKALLE--DFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTEN 875
            Q  +  +  LE  D +  L ++E  RL+ +   A+ + +  VE  +   R+ Q+EE ++ 
Sbjct: 2213 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS-QVEEELFSVRV-QMEELSKL 2270

Query: 876  KLGELGSSAESKGALKKEREVHQKLLAD 903
            K       AE++  + ++++  Q+ L +
Sbjct: 2271 K---ARIEAENRALILRDKDNTQRFLQE 2295



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 137/623 (21%), Positives = 247/623 (39%), Gaps = 75/623 (12%)

Query: 11   EDVYQLQELRRELDRANKNCRILQYRLRK-AEQKSLKVAETGQVDGELIRSLEQDLKVAK 69
            E+  +L++   E  +A    +    +LRK AEQ++ + A+  Q       +L Q  K A 
Sbjct: 2139 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA------ALRQ--KQAA 2190

Query: 70   DVSVRLHHEL--KTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRST 127
            D  +  H +   +T+ +K A+ E E  TLR Q+ E +  K  L  EL+RLK  +      
Sbjct: 2191 DAEMEKHKKFAEQTLRQK-AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA------ 2243

Query: 128  REMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDV 187
                         ++A  R Q++   EE F +R +M +L + K  +E E +    +  D 
Sbjct: 2244 ------------TEAARQRSQVE---EELFSVRVQMEELSKLKARIEAENRAL--ILRDK 2286

Query: 188  DSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQE 247
            D+     +       + AE   RL +  +EA  L +   E   + R L  +M   + Q  
Sbjct: 2287 DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV 2346

Query: 248  REGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELS 307
            +E         +         E + E  R LQ  E++ ++ ++   E +   R L  E  
Sbjct: 2347 QEATRLKAEAEL----LQQQKELAQEQARRLQ--EDKEQMAQQLAEETQGFQRTLEAERQ 2400

Query: 308  KFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQ 367
            + + E   E   L    +  +   A  +E+ +  R Q  E+  K+ + +      ++ +Q
Sbjct: 2401 R-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2459

Query: 368  RCDLAAHLGLRAPSPRDSDAESDA-----GKKESDGEESRLPQPKRE--GPVGGESDSEE 420
              ++      R  S  D++   +A      +KE   +E++L Q K E    V  E   +E
Sbjct: 2460 TLEIQ-----RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2514

Query: 421  MFEKTSGFGSGKPSEASEPCPTELLKAR------EDSEYLVTLKHEAQRLERTVERLITD 474
                   F S K S        E  KA+      ++      L+ E QR ++ +E+    
Sbjct: 2515 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2574

Query: 475  TDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQ--QEPQLLGTINAKMKAFKKELQAFLEQ 532
              + + +A  R      G   + EE Q    Q  Q+ +LL   N ++   +++LQ  LE+
Sbjct: 2575 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL---REQLQ-LLEE 2630

Query: 533  VNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPAR 592
             +R          L  S    ++  + ++  P G    + GP  ++  +   +       
Sbjct: 2631 QHRAA--------LAHSEEVTASQVAATKTLPNGRDALD-GPAAEAEPEHSFDGLRRKVS 2681

Query: 593  GDERESLRLRAARELHRRADGDT 615
                +   + +A EL R A G T
Sbjct: 2682 AQRLQEAGILSAEELQRLAQGHT 2704



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 204/988 (20%), Positives = 374/988 (37%), Gaps = 196/988 (19%)

Query: 36   RLRKAEQKSLKVAETGQVDGELIRSLEQDL---KVAKDVSVRLHHELKTVEEKRAKAEDE 92
            RL    +K L + E       L   LE  L   +  + +S     +LKT+       +  
Sbjct: 1069 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1128

Query: 93   NETLR---QQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQL 149
             E LR   +Q+ E +     L  ELE  K S  K R+  E   ++ TF+      LR +L
Sbjct: 1129 EEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEA--QQPTFDA-----LRDEL 1180

Query: 150  QFAKEEAFLMRKKMAK----LGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREA 205
            + A+E    ++++  +    + R ++ + Q L++++++    D              R+ 
Sbjct: 1181 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD-------------VRQR 1227

Query: 206  ELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFG 265
            EL+            LGR++         L A ++D R +QE+          I   P  
Sbjct: 1228 ELEQ-----------LGRQLRYYRESADPLGAWLQDARRRQEQ----------IQAMPLA 1266

Query: 266  DSLESSTELR----------RHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPR 315
            DS     +LR          RH + VEE     ++ I+ I+D+  QL     K + EP  
Sbjct: 1267 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLV--TYKAQLEPVA 1324

Query: 316  EPGWLGEGASPGAGGGAPLQE--ELKSARLQISELSGKVLKL------QHENHALLSNIQ 367
             P    +     +G  + +QE  +L++   +++ L+ + +K       + E    L+  Q
Sbjct: 1325 SP---AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1381

Query: 368  RCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSG 427
            R +    L        + +A  +  ++ ++       Q +RE     +   EE+  +   
Sbjct: 1382 RAEERERLA-------EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1434

Query: 428  FGSGKPSEASEPCPTELLKAREDSEYLVTLK-HEAQRLERTVERLITDTDSFLHDAGLRG 486
                +  + S     EL + R+ SE  +  K  +A+  ER+  R+    +  +    L+ 
Sbjct: 1435 AVDAQQQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRI----EEEIRVVRLQ- 1487

Query: 487  GAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHL 546
                    L+  E Q  G + E Q L     + +A K++ Q   E++ R           
Sbjct: 1488 --------LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR----------- 1528

Query: 547  TESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDER-----ESLRL 601
                        V  +S      ++   +L SR+K + E     AR  +R     E LRL
Sbjct: 1529 -----------QVQDES---QRKRQAEVELASRVKAEAE----AAREKQRALQALEELRL 1570

Query: 602  RAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEET 661
            + A E  RR                   LR   V   + V +     Q    A L Q + 
Sbjct: 1571 Q-AEEAERR-------------------LRQAEVERARQVQVALETAQRSAEAEL-QSKR 1609

Query: 662  ETFTNKIHKME----EEHLYALRWKELEMHSLALQNTLHERTWSD-EKNLMQQELRSLKQ 716
             +F  K  ++E    EEH+   + +E E    A Q    ER   + E+ L + +L++ + 
Sbjct: 1610 ASFAEKTAQLERSLQEEHVAVAQLRE-EAERRAQQQAEAERAREEAERELERWQLKANEA 1668

Query: 717  NIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSD 776
                  ++LR   +   Q K + +   E  + E      R G+   Q   Q +  + + +
Sbjct: 1669 ------LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1722

Query: 777  RGCGFPVGEHSPHSRVQIGDHSLRLQT-ADRGQPHKQVVENQ------------QLFSAF 823
            +     + E +   R+      +RL+   ++G+  +Q++E +            Q     
Sbjct: 1723 K--QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1780

Query: 824  KALLEDFRAEL----------REDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKT 873
            +A L   RAE+           E+ R+     +Q    +A    E A    RL  L E+ 
Sbjct: 1781 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1840

Query: 874  ENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELL--- 930
            + +  +L     ++   + ER + +KL A   +  +    +I   EK    E++  L   
Sbjct: 1841 KRQ-RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1899

Query: 931  DRLDRDRQEWE--RQKKEFLWRIEQLQK 956
            +   R R E +  + K +   R+ QL+K
Sbjct: 1900 EAFQRRRLEEQAAQHKADIEERLAQLRK 1927



 Score = 38.9 bits (89), Expect = 0.040
 Identities = 87/408 (21%), Positives = 169/408 (41%), Gaps = 56/408 (13%)

Query: 577  QSRLKEQLE-WQLGPARGDERESLRLRAAREL-HRRADGDTGSHGLGGQTCFSLELRGPP 634
            + R+ + LE WQ   A+ D R+    +  R+L + R   D     L        +++  P
Sbjct: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264

Query: 635  VLPEQSVSIEELQGQ-LVQAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQN 693
            +   Q+V  +  Q Q L++    H E+ E    +  +  ++++ A++  EL++ +   Q 
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVE----ECQRFAKQYINAIKDYELQLVTYKAQL 1320

Query: 694  TLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRW-----------LLKHWRQGKQMEEEG 742
               E   S  K   + +++S  +++   YV LR             +K   +  +  EE 
Sbjct: 1321 ---EPVASPAK---KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE 1374

Query: 743  EEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQ 802
            E   E +  E   RL E  V+   +      ++           +   + ++ +  +R +
Sbjct: 1375 ERLAEQQRAEERERLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1432

Query: 803  TA--DRGQPHKQVVEN-QQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEW 859
             A  D  Q  + + E  QQL  + +A ++    +    ER+RLR+++           E 
Sbjct: 1433 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE-----------EI 1481

Query: 860  AVLKCRLEQLEEK---TENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIH 916
             V++ +LE  E +    E +L  L + AE   A K++ +   +           LR Q+ 
Sbjct: 1482 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE----------RLRRQVQ 1531

Query: 917  HSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQ--LQKENSPRR 962
               +   + +VEL  R+ +   E  R+K+  L  +E+  LQ E + RR
Sbjct: 1532 DESQRKRQAEVELASRV-KAEAEAAREKQRALQALEELRLQAEEAERR 1578


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 211/965 (21%), Positives = 369/965 (38%), Gaps = 184/965 (19%)

Query: 49   ETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQ 108
            ++ Q + +     ++ L   K+   +   EL+  +EK A  E  +E        ++IS+Q
Sbjct: 819  DSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSE--------LQISRQ 870

Query: 109  ALQNELERLKESSLKRRSTREMYKEKKTFN-QDDSADLRCQLQFAKEEAFLMRKKMAKLG 167
              QNEL  L  ++L R   +   KE +     DD + L+ ++    +E   +   + K G
Sbjct: 871  --QNELAEL-HANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAG 927

Query: 168  REKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVE 227
             +++   +EL K  +  GD        + G    + +A L+     +E EA  +G ++  
Sbjct: 928  EQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQA----MEREAEQMGNELER 983

Query: 228  LEVENRGLKAEMEDMRGQQERE------GPGRDHAPSIPTSPFGDSLESSTELRRHLQFV 281
            L       + + ++ RGQQERE        GR  A           LE   +   + Q V
Sbjct: 984  LRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRV 1043

Query: 282  E-----------------EEAELLR---------RSISEIEDHNRQLTHELSKFKFEPPR 315
            E                 ++ EL +         + + E+    +QL  +L+K + E   
Sbjct: 1044 EFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHAS 1103

Query: 316  EPGWLGEGA-SPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAH 374
                 G GA S  AG   P   +L++ R ++S+L  +  K Q +  +L  +++     A 
Sbjct: 1104 -----GSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLE-----AE 1153

Query: 375  LGLRAPSPRDSDAESDAGKKESDGEE-----SRLPQPKRE-----GPVGGESDSEEMF-- 422
               RA   RDS  E+  G+ E   +E     S L   +RE       V   S +E+ +  
Sbjct: 1154 RASRA--ERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKA 1211

Query: 423  ---------EKTSGFGSGKPSEASEPCPTELLKAREDSE---YLVTLKHEAQRLERTVER 470
                     E+ +   S    E S      L K  E  E    ++    ++Q+LE  +  
Sbjct: 1212 QVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRL 1271

Query: 471  LITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKM---------KA 521
            L  +T S    A  R  A         EE Q   ++ E Q + + N +          + 
Sbjct: 1272 LQAETASNSARAAERSSA-------LREEVQSLREEAEKQRVASENLRQELTSQAERAEE 1324

Query: 522  FKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPD---LQS 578
              +EL+A+ E+  +    LS L          ST   VS   P  +L ++L  +    + 
Sbjct: 1325 LGQELKAWQEKFFQKEQALSTL-----QLEHTSTQALVSELLPAKHLCQQLQAEQAAAEK 1379

Query: 579  RLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPE 638
            R +E+LE Q   A G  R  L LRA REL                        G  +   
Sbjct: 1380 RHREELE-QSKQAAGGLRAEL-LRAQREL------------------------GELIPLR 1413

Query: 639  QSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEHLYAL--------RWKELEMHSLA 690
            Q V+ +E   Q ++A +    E  +   K H +  E    L        ++ E+E+    
Sbjct: 1414 QKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAR 1473

Query: 691  ---LQNTLHERTWSDEKNL-MQQELRSLKQNIFLFYVKLRWLLKHWRQGKQME--EEGEE 744
               +Q     R  ++ +   +Q+E +S  + + +   K         +G +++  EE + 
Sbjct: 1474 EKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKY--------EGAKVKVLEERQR 1525

Query: 745  FTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTA 804
            F E E  +  +++ +L V    Q    +  S +     + +    S+VQ     L+   A
Sbjct: 1526 FQE-ERQKLTAQVEQLEVFQREQTKQVEELSKK-----LADSDQASKVQ--QQKLKAVQA 1577

Query: 805  DRGQPHKQVVENQQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDV------E 858
              G       E+QQ     +A L + +A+L + E+A    + Q    K  +D       E
Sbjct: 1578 QGG-------ESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQE 1630

Query: 859  WAVLKCRLEQLEEKTENKLGE---LGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQI 915
                   LEQL+++ +    E   LG   +  G   KE E   + L    + V  L  Q+
Sbjct: 1631 LQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLT---AQVRSLEAQV 1687

Query: 916  HHSEK 920
             H+++
Sbjct: 1688 AHADQ 1692



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 207/994 (20%), Positives = 378/994 (38%), Gaps = 170/994 (17%)

Query: 15   QLQELRRELDRANKNCRILQYRL----RKAEQKSLKVAETGQVDGELIRSL--------- 61
            Q+  L  EL   N   +     L    ++A++K  ++A+T Q   +  + L         
Sbjct: 499  QVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSS 558

Query: 62   -----EQDLK--VAKDVSVRLHH--ELKTVEEKRAKAEDENETLRQQMIEVEISKQA--- 109
                 EQ LK    K  + R  H  +L T  E+R  +  E +   +Q+  +E  K A   
Sbjct: 559  SLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLE 618

Query: 110  -LQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKL-- 166
             LQ +L+   E+    +++    + +K        +L+  ++ A++E    + ++A+L  
Sbjct: 619  ILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELEL 678

Query: 167  ---------------GREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRL 211
                            +EKD+L+++LQ  K         L            E E +   
Sbjct: 679  QLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSL------------EEEKRRAA 726

Query: 212  KLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESS 271
              +EE+     R I EL+ E R L  + +  R + E E  GR              LE+ 
Sbjct: 727  DALEEQQ----RCISELKAETRSLVEQHKRERKELEEERAGR------------KGLEA- 769

Query: 272  TELRRHLQFVEEEAELLRRSISE-------IEDHNRQLTHELSKF--KFEPPREPGWLGE 322
              L++  +  + E E+LRR ++E        E    QL  E++ +  ++E  ++     E
Sbjct: 770  -RLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ-----E 823

Query: 323  GASPGA---GGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRA 379
             A  GA        L+EE + AR ++ E   KV  ++  +   +S  Q      H  L  
Sbjct: 824  EAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLAR 883

Query: 380  PSPRDSDAESDAGKKESD------------GEESRLPQPKREGPVGGESDSEEMFEKTSG 427
               +  + E  A K   D             E +RL    R+     E+ S E+ ++ + 
Sbjct: 884  ALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPAR 943

Query: 428  FGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDAGLRGG 487
             G  +P         E L+ ++  ++  T +   Q +ER  E++  + +        R  
Sbjct: 944  AGDRQP---------EWLEEQQGRQFCST-QAALQAMEREAEQMGNELE--------RLR 985

Query: 488  APLPGPGLQGEEEQGEGDQQEPQLL---GTINAKM---KAFKKELQAFLEQVNRIGDGLS 541
            A L     Q +EE+G+ +++  +L    G   A +   KA + EL+  L+  N + +   
Sbjct: 986  AALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ--NALNEQRV 1043

Query: 542  PLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLRL 601
                L E+ +   T     ++     L K  G +  +++KE  E +         + L+ 
Sbjct: 1044 EFATLQEALAHALT----EKEGKDQELAKLRGLE-AAQIKELEELR------QTVKQLKE 1092

Query: 602  RAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEET 661
            + A++    A G        G+T    E  GP         +E L+ ++ +  +  Q++ 
Sbjct: 1093 QLAKKEKEHASGSGAQSEAAGRT----EPTGP--------KLEALRAEVSKLEQQCQKQQ 1140

Query: 662  ETFTNKIHKMEEEHL-YALRWKELEMHSLALQNTLHERTWSDEKNLMQQELRSLKQNIFL 720
            E   +    +E E    A R   LE     LQ  L E+  + E    Q  L S ++ +  
Sbjct: 1141 EQADSLERSLEAERASRAERDSALE----TLQGQLEEK--AQELGHSQSALASAQRELAA 1194

Query: 721  FYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCG 780
            F  K++   K   + K     G +  E ++    S   E+ +    Q    + +S     
Sbjct: 1195 FRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSIL-NRQVLEKEGESKELKR 1253

Query: 781  FPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFSAFKALLEDFRAELREDERA 840
              + E     ++   +  LRL  A+      +  E     SA +  ++  R E  +   A
Sbjct: 1254 LVMAESEKSQKL---EERLRLLQAETASNSARAAERS---SALREEVQSLREEAEKQRVA 1307

Query: 841  RLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELGSSAESKGALKKE----REV 896
               L+Q+  S     +     LK   E+  +K E  L  L     S  AL  E    + +
Sbjct: 1308 SENLRQELTSQAERAEELGQELKAWQEKFFQK-EQALSTLQLEHTSTQALVSELLPAKHL 1366

Query: 897  HQKLLADSHSLVMDLRWQIHHSEKNWNREKVELL 930
             Q+L A+  +     R ++  S++     + ELL
Sbjct: 1367 CQQLQAEQAAAEKRHREELEQSKQAAGGLRAELL 1400



 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 156/838 (18%), Positives = 316/838 (37%), Gaps = 175/838 (20%)

Query: 108 QALQNELERLKESSLKRRSTR-----EMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKK 162
           Q  Q ++ RLK+     RS R     E+ + +K   + D+     Q +   +   L+ +K
Sbjct: 210 QTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRI--DRLALLNEK 267

Query: 163 MAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILG 222
            A    E  ELE+   K +SL                 + R  E   + + ++ E + + 
Sbjct: 268 QAASPLEPKELEELRDKNESL-----------------TMRLHETLKQCQDLKTEKSQMD 310

Query: 223 RKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHL---- 278
           RKI +L  EN  L  ++ +     ++     +      +    + LE   +L + L    
Sbjct: 311 RKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAAL 370

Query: 279 ---QFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQ 335
              + +EE+ E+L+  +S++E+H       LS+ +  PP+E G                 
Sbjct: 371 QDKKCLEEKNEILQGKLSQLEEH-------LSQLQDNPPQEKG----------------- 406

Query: 336 EELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKE 395
            E+    LQ+  L  +   L   N  L + ++  +            +++   ++ G  E
Sbjct: 407 -EVLGDVLQLETLKQEAATLAANNTQLQARVEMLETER-------GQQEAKLLAERGHFE 458

Query: 396 SDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTEL----LKAREDS 451
            + ++        +  +   S ++E  E+ S     + +       +EL       ++  
Sbjct: 459 EEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQD 518

Query: 452 EYLVTLKHEAQRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGE--GDQQE- 508
           + L  LK +A+  +  + + +   +      GLR         L+ +E+Q +   ++QE 
Sbjct: 519 QELAGLKQQAKEKQAQLAQTLQQQEQ--ASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEA 576

Query: 509 -----PQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDS 563
                 Q L T   + +A  +E  A L+Q+  +    +    + +    ++     S  +
Sbjct: 577 TRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQT 636

Query: 564 PIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQ 623
            +    +E      SR  E+L+  +  AR ++ E+    A  EL  R++           
Sbjct: 637 SVTQAQREKAE--LSRKVEELQACVETARQEQHEAQAQVAELELQLRSE----------- 683

Query: 624 TCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEHLYALRWKE 683
                                  Q +  +  R+ QE+ +          +E L AL+ + 
Sbjct: 684 -----------------------QQKATEKERVAQEKDQL---------QEQLQALK-ES 710

Query: 684 LEMHSLALQNTLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRWLL-KHWRQGKQMEEEG 742
           L++   +L+         +EK      L   ++ I     + R L+ +H R+ K++EEE 
Sbjct: 711 LKVTKGSLE---------EEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE- 760

Query: 743 EEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQ 802
                        R G  G++   Q  G  H ++          +   R ++ +      
Sbjct: 761 -------------RAGRKGLEARLQQLGEAHQAE----------TEVLRRELAEAMAAQH 797

Query: 803 TADR--GQPHKQVV-------ENQQLFSAFKALLEDFRAELRED-ERARLRLQQQYASDK 852
           TA+    Q  K+V        ++QQ  + + A+ ++    L+E+ E+AR  LQ+  A +K
Sbjct: 798 TAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQE--AKEK 855

Query: 853 AAWDVEWAVLKCRLEQLEEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMD 910
            A       ++   E    + +N+L EL ++        +E+EV  + LAD  S + +
Sbjct: 856 VAG------IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQE 907



 Score = 35.8 bits (81), Expect = 0.34
 Identities = 37/232 (15%), Positives = 101/232 (43%), Gaps = 29/232 (12%)

Query: 24   DRANKNCRILQYRLRKAEQKSLKVAETGQVDGE-----LIRSLEQDLKVAKDVSVRLHHE 78
            +RAN   + L+  L +A +K ++     + D E     + R  +   +  + ++ +    
Sbjct: 1456 ERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGA 1515

Query: 79   LKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFN 138
               V E+R + ++E + L  Q+ ++E+ ++    ++E L +         ++ ++K    
Sbjct: 1516 KVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAV 1575

Query: 139  QDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGG 198
            Q    + + + Q  + +   ++ ++++  +  +  + +++K K+ Y              
Sbjct: 1576 QAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYD------------- 1622

Query: 199  PPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREG 250
                +  EL+ +L+ +E+           L+ EN+ L+AE E +  + ++ G
Sbjct: 1623 AKKQQNQELQEQLRSLEQ-----------LQKENKELRAEAERLGHELQQAG 1663



 Score = 35.8 bits (81), Expect = 0.34
 Identities = 36/139 (25%), Positives = 61/139 (43%), Gaps = 5/139 (3%)

Query: 15   QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDV--- 71
            QL EL+ +L +  +     + ++ KA+       +  Q   E +RSLEQ  K  K++   
Sbjct: 1592 QLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAE 1651

Query: 72   SVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRS--TRE 129
            + RL HEL+    K  +AE     L  Q+  +E        +L  L +  +   +  +RE
Sbjct: 1652 AERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSRE 1711

Query: 130  MYKEKKTFNQDDSADLRCQ 148
               + +     DS DL C+
Sbjct: 1712 PQAKPQLDLSIDSLDLSCE 1730


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 169/763 (22%), Positives = 306/763 (40%), Gaps = 105/763 (13%)

Query: 9    LEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVA-ETGQVDGEL------IRSL 61
            LE  + Q ++LR +L+RA +    L+  L+ A++  + +  E  Q+D +L      I +L
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRK---LEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNL 1096

Query: 62   EQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNEL----ERL 117
            +  ++  + + ++L  ++K ++ +  + E+E E  R    + E  +  L  EL    ERL
Sbjct: 1097 QSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1156

Query: 118  KESSLKRRSTREMYKEKKTFNQDDSADL-RCQLQFAKEEAFLMRK---KMAKLGREKDEL 173
            +E+     +  EM K+++   Q    DL    LQ     A L +K    +A+LG + D L
Sbjct: 1157 EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNL 1216

Query: 174  E---QELQKYKS-LYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELE 229
            +   Q+L+K KS +  ++D      E     S  +  L+   + +E++ + L  K    E
Sbjct: 1217 QRVKQKLEKEKSEMKMEIDDLASNVET---VSKAKGNLEKMCRTLEDQLSELKSK----E 1269

Query: 230  VENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESS----TELRRHLQFVEEEA 285
             E + L  ++   RG+ + E           +  F   L+      ++L R  Q   ++ 
Sbjct: 1270 EEQQRLINDLTAQRGRLQTE-----------SGEFSRQLDEKEALVSQLSRGKQAFTQQI 1318

Query: 286  ELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQI 345
            E L+R + E       L H L   +     +   L E         A LQ  L  A  ++
Sbjct: 1319 EELKRQLEEEIKAKNALAHALQSSR----HDCDLLREQYEEEQESKAELQRALSKANTEV 1374

Query: 346  SELSGK-----VLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEE 400
            ++   K     + + +    A     QR   AA   + A + + +  E    + +++ E+
Sbjct: 1375 AQWRTKYETDAIQRTEELEEAKKKLAQRLQ-AAEEHVEAVNAKCASLEKTKQRLQNEVED 1433

Query: 401  SRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEA----------SEPCPTELLKAR-- 448
              L   +           +  F+K       K  E           +    TEL K +  
Sbjct: 1434 LMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNA 1493

Query: 449  --EDSEYLVTLKHEAQRLERTVERL---ITDTDSFLHD-AGLRGGAPLPGPGLQGEEEQG 502
              E  + L TLK E + L++ +  L   I +    +H+   ++         LQ   E+ 
Sbjct: 1494 YEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEA 1553

Query: 503  EG--DQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSV- 559
            E   + +E ++L  I  ++   K E+   + + +   D L    H+    S  ST+ +  
Sbjct: 1554 EASLEHEEGKIL-RIQLELNQVKSEVDRKIAEKDEEIDQLK-RNHIRIVESMQSTLDAEI 1611

Query: 560  -SRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLRLRAARELHRRADG---DT 615
             SR+  I  L K++  DL      ++E QL  A     E+LR       +R   G   DT
Sbjct: 1612 RSRNDAI-RLKKKMEGDL-----NEMEIQLNHANRMAAEALR------NYRNTQGILKDT 1659

Query: 616  GSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEH 675
              H           LR    L EQ   +E  +  L+QA       T   T +  K+ E+ 
Sbjct: 1660 QIH-------LDDALRSQEDLKEQLAMVER-RANLLQAEIEELRATLEQTERSRKIAEQE 1711

Query: 676  LY--ALRWKELEMHSLALQNTLHERTWSDEKNLMQQELRSLKQ 716
            L   + R + L   + +L NT  ++    + + MQ E+  + Q
Sbjct: 1712 LLDASERVQLLHTQNTSLINT--KKKLETDISQMQGEMEDILQ 1752



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 109/538 (20%), Positives = 205/538 (38%), Gaps = 89/538 (16%)

Query: 15   QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVR 74
            ++++L  +++R N  C  L  + R  ++    +AE  Q   E    LE   K A+ +   
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRNFDKI---LAEWKQKCEETHAELEASQKEARSLGTE 1486

Query: 75   LHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKR-RSTREMYKE 133
            L       EE      D+ ETL+++        + LQ E+  L E   +  +   E+ K 
Sbjct: 1487 LFKIKNAYEESL----DQLETLKRE-------NKNLQQEISDLTEQIAEGGKRIHELEKI 1535

Query: 134  KKTFNQDDSADLRCQLQFAKEEAFL-MRKKMAKLGREKDELEQELQKYKSLYGDVDSPLP 192
            KK   Q+     +C+LQ A EEA   +  +  K+ R + EL Q   +      + D  + 
Sbjct: 1536 KKQVEQE-----KCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590

Query: 193  TGEAG------GPPSTREAELKLRLKLVEEEANILGRKIVELEVE-NRGLKAEMEDMRGQ 245
              +           ST +AE++ R   +  +  + G  + E+E++ N   +   E +R  
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG-DLNEMEIQLNHANRMAAEALRNY 1649

Query: 246  QEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHE 305
            +  +G  +D    +      D+L S  +L+  L  VE  A LL+  I E+     Q    
Sbjct: 1650 RNTQGILKDTQIHLD-----DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQT--- 1701

Query: 306  LSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSN 365
                                         +   K A  ++ + S +V  L  +N +L++ 
Sbjct: 1702 -----------------------------ERSRKIAEQELLDASERVQLLHTQNTSLINT 1732

Query: 366  IQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKT 425
             ++ +              +D     G+ E   +E+R  + K +  +   +   E  +K 
Sbjct: 1733 KKKLE--------------TDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKE 1778

Query: 426  SGFGSG--KPSEASEPCPTELLKAREDSEYLVTL--KHEAQRLERTVERLITDTDSFLHD 481
                +   +  +  E    +L    +++E L     K + Q+LE  V  L  + +S    
Sbjct: 1779 QDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKR 1838

Query: 482  -----AGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVN 534
                  GLR             EE  +   +   L+  + AK+K++K++ +   EQ N
Sbjct: 1839 NAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1896



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 175/1001 (17%), Positives = 383/1001 (38%), Gaps = 168/1001 (16%)

Query: 15   QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVR 74
            +  EL++++D        ++      E K   + E      E I  L ++ K  ++   +
Sbjct: 952  ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011

Query: 75   LHHELKTVEEK-----------RAKAEDENETLRQQM---IEVEISKQALQNELERLKES 120
               +L+  E+K             + +D   +L Q+    +++E +K+ L+ +L+  +ES
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071

Query: 121  SLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKY 180
             +   + ++   EK    + + ++L+ +++  +     ++KK+ +L    +ELE+E++  
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE 1131

Query: 181  KSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKI---VELEVENRGLKA 237
            ++            +A    S    EL+   + +EE       +I    + E E + ++ 
Sbjct: 1132 RA---------SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1182

Query: 238  EMEDMRGQQEREGP--GRDHAPSIPTSPFGDSLES-----------STELRRHLQFVEEE 284
            ++E+   Q E       + HA S+  +  G+ +++            +E++  +  +   
Sbjct: 1183 DLEEATLQHEATAATLRKKHADSV--AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN 1240

Query: 285  AELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQ 344
             E + ++   +E   R L  +LS+ K +   +   + +  +        LQ E      Q
Sbjct: 1241 VETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQ----RGRLQTESGEFSRQ 1296

Query: 345  ISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSP-----RDSDAESDAGKKESDGE 399
            + E    V +L     A    I+         ++A +      + S  + D  +++ + E
Sbjct: 1297 LDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEE 1356

Query: 400  -ESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLK 458
             ES+    +       E        +T      +  E ++    + L+A E  E++  + 
Sbjct: 1357 QESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAE--EHVEAVN 1414

Query: 459  HEAQRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAK 518
             +   LE+T +RL  + +  + D      A         +++Q   D    ++L     K
Sbjct: 1415 AKCASLEKTKQRLQNEVEDLMLDVERTNAA-----CAALDKKQRNFD----KILAEWKQK 1465

Query: 519  MKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQS 578
             +    EL+A  ++   +G  L  + +  E S  L  + ++ R++   NL +E+  DL  
Sbjct: 1466 CEETHAELEASQKEARSLGTELFKIKNAYEES--LDQLETLKRENK--NLQQEIS-DLTE 1520

Query: 579  RLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPE 638
            ++ E      G  R  E E ++ +  +E                      EL+    L E
Sbjct: 1521 QIAE------GGKRIHELEKIKKQVEQE--------------------KCELQA--ALEE 1552

Query: 639  QSVSIEELQGQLVQ-AARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHE 697
               S+E  +G++++    L+Q ++E    KI + +EE              +      H 
Sbjct: 1553 AEASLEHEEGKILRIQLELNQVKSEV-DRKIAEKDEE--------------IDQLKRNHI 1597

Query: 698  RTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL 757
            R     ++ +  E+RS    I              R  K+ME +               L
Sbjct: 1598 RIVESMQSTLDAEIRSRNDAI--------------RLKKKMEGD---------------L 1628

Query: 758  GELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQP--HKQVVE 815
             E+ +Q  H        ++R     +  +  +++  + D  + L  A R Q    +Q+  
Sbjct: 1629 NEMEIQLNH--------ANRMAAEALRNYR-NTQGILKDTQIHLDDALRSQEDLKEQLAM 1679

Query: 816  NQQLFSAFKALLEDFRAELREDERARLRLQQQY--ASDKA----AWDVEWAVLKCRLEQL 869
             ++  +  +A +E+ RA L + ER+R   +Q+   AS++       +      K +LE  
Sbjct: 1680 VERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD 1739

Query: 870  EEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVEL 929
              + + ++ ++   A +     K+      ++A+      D    +   +KN  +   +L
Sbjct: 1740 ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDL 1799

Query: 930  LDRLD-----------RDRQEWERQKKEFLWRIEQLQKENS 959
              RLD           +  Q+ E + +E    +E  QK N+
Sbjct: 1800 QLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNA 1840



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 65/308 (21%), Positives = 126/308 (40%), Gaps = 42/308 (13%)

Query: 102  EVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRK 161
            E E     ++ E +++K+   K  + R+  +EK      +  DL+ Q+Q   E      +
Sbjct: 850  ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909

Query: 162  KMAKLGREKDELEQELQKYKSLYGD---VDSPLPTGEAGGPPSTREA-----ELKLRLKL 213
            +  +L + K +LE ++++      D   +++ L   +        E      +L+L L  
Sbjct: 910  RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 969

Query: 214  VEEEANILGRKIVELEVENRGL------------------KAEMEDMRGQQEREGPGRDH 255
            VE+E +    K+  L  E  GL                  +  ++D++ ++++       
Sbjct: 970  VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT-- 1027

Query: 256  APSIPTSPFGDSLESSTELRRHLQF--------VEEEAELLRRSISEIEDHNRQLTHELS 307
               I      D LE S E  + L+         +E + +L + SI +IE+  +QL  +L 
Sbjct: 1028 KAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLK 1087

Query: 308  KFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQ 367
            K +FE       L          G  LQ+++K  + +I EL  ++ + +  + A     Q
Sbjct: 1088 KKEFEISN----LQSKIEDEQALGIQLQKKIKELQARIEELEEEI-EAERASRAKAEK-Q 1141

Query: 368  RCDLAAHL 375
            R DL+  L
Sbjct: 1142 RSDLSREL 1149



 Score = 32.7 bits (73), Expect = 2.9
 Identities = 80/353 (22%), Positives = 142/353 (40%), Gaps = 40/353 (11%)

Query: 142  SADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPS 201
            SA+   ++   KEE   ++ ++AK   ++ ELE+++        D+   +   EA G   
Sbjct: 848  SAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV-QAEAEGLAD 906

Query: 202  TRE---------AELKLRLKLV------EEEANI-LGRKIVELEVENRGLKAEMEDMR-- 243
              E          +L+ ++K V      EEE N  L  K  +LE E   LK +++D+   
Sbjct: 907  AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 966

Query: 244  -GQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQL 302
              + E+E    ++     T       E+  +L +  + ++E  +     +   ED    L
Sbjct: 967  LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026

Query: 303  THELSKFKFEPPREPGWLG---------EGASPGAGGGAPL-QEELKSARLQISELSGKV 352
            T    K + +     G L          E A     G   L QE +     +  +L  K+
Sbjct: 1027 TKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKL 1086

Query: 353  LKLQHENHALLSNIQ-RCDLAAHLGLRAPSP-RDSDAESDAGKKESDGEE-SRLPQPKRE 409
             K + E    +SN+Q + +    LG++     ++  A  +  ++E + E  SR    K+ 
Sbjct: 1087 KKKEFE----ISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1142

Query: 410  GPVGGE-SDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEA 461
              +  E  +  E  E+  G  S +  E ++    E  K R D E   TL+HEA
Sbjct: 1143 SDLSRELEEISERLEEAGGATSAQ-IEMNKKREAEFQKMRRDLEE-ATLQHEA 1193


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 169/763 (22%), Positives = 306/763 (40%), Gaps = 105/763 (13%)

Query: 9    LEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVA-ETGQVDGEL------IRSL 61
            LE  + Q ++LR +L+RA +    L+  L+ A++  + +  E  Q+D +L      I +L
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRK---LEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNL 1096

Query: 62   EQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNEL----ERL 117
            +  ++  + + ++L  ++K ++ +  + E+E E  R    + E  +  L  EL    ERL
Sbjct: 1097 QSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1156

Query: 118  KESSLKRRSTREMYKEKKTFNQDDSADL-RCQLQFAKEEAFLMRK---KMAKLGREKDEL 173
            +E+     +  EM K+++   Q    DL    LQ     A L +K    +A+LG + D L
Sbjct: 1157 EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNL 1216

Query: 174  E---QELQKYKS-LYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELE 229
            +   Q+L+K KS +  ++D      E     S  +  L+   + +E++ + L  K    E
Sbjct: 1217 QRVKQKLEKEKSEMKMEIDDLASNVET---VSKAKGNLEKMCRTLEDQLSELKSK----E 1269

Query: 230  VENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESS----TELRRHLQFVEEEA 285
             E + L  ++   RG+ + E           +  F   L+      ++L R  Q   ++ 
Sbjct: 1270 EEQQRLINDLTAQRGRLQTE-----------SGEFSRQLDEKEALVSQLSRGKQAFTQQI 1318

Query: 286  ELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQI 345
            E L+R + E       L H L   +     +   L E         A LQ  L  A  ++
Sbjct: 1319 EELKRQLEEEIKAKNALAHALQSSR----HDCDLLREQYEEEQESKAELQRALSKANTEV 1374

Query: 346  SELSGK-----VLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEE 400
            ++   K     + + +    A     QR   AA   + A + + +  E    + +++ E+
Sbjct: 1375 AQWRTKYETDAIQRTEELEEAKKKLAQRLQ-AAEEHVEAVNAKCASLEKTKQRLQNEVED 1433

Query: 401  SRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEA----------SEPCPTELLKAR-- 448
              L   +           +  F+K       K  E           +    TEL K +  
Sbjct: 1434 LMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNA 1493

Query: 449  --EDSEYLVTLKHEAQRLERTVERL---ITDTDSFLHD-AGLRGGAPLPGPGLQGEEEQG 502
              E  + L TLK E + L++ +  L   I +    +H+   ++         LQ   E+ 
Sbjct: 1494 YEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEA 1553

Query: 503  EG--DQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSV- 559
            E   + +E ++L  I  ++   K E+   + + +   D L    H+    S  ST+ +  
Sbjct: 1554 EASLEHEEGKIL-RIQLELNQVKSEVDRKIAEKDEEIDQLK-RNHIRIVESMQSTLDAEI 1611

Query: 560  -SRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLRLRAARELHRRADG---DT 615
             SR+  I  L K++  DL      ++E QL  A     E+LR       +R   G   DT
Sbjct: 1612 RSRNDAI-RLKKKMEGDL-----NEMEIQLNHANRMAAEALR------NYRNTQGILKDT 1659

Query: 616  GSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEH 675
              H           LR    L EQ   +E  +  L+QA       T   T +  K+ E+ 
Sbjct: 1660 QIH-------LDDALRSQEDLKEQLAMVER-RANLLQAEIEELRATLEQTERSRKIAEQE 1711

Query: 676  LY--ALRWKELEMHSLALQNTLHERTWSDEKNLMQQELRSLKQ 716
            L   + R + L   + +L NT  ++    + + MQ E+  + Q
Sbjct: 1712 LLDASERVQLLHTQNTSLINT--KKKLETDISQMQGEMEDILQ 1752



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 109/538 (20%), Positives = 205/538 (38%), Gaps = 89/538 (16%)

Query: 15   QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVR 74
            ++++L  +++R N  C  L  + R  ++    +AE  Q   E    LE   K A+ +   
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRNFDKI---LAEWKQKCEETHAELEASQKEARSLGTE 1486

Query: 75   LHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKR-RSTREMYKE 133
            L       EE      D+ ETL+++        + LQ E+  L E   +  +   E+ K 
Sbjct: 1487 LFKIKNAYEESL----DQLETLKRE-------NKNLQQEISDLTEQIAEGGKRIHELEKI 1535

Query: 134  KKTFNQDDSADLRCQLQFAKEEAFL-MRKKMAKLGREKDELEQELQKYKSLYGDVDSPLP 192
            KK   Q+     +C+LQ A EEA   +  +  K+ R + EL Q   +      + D  + 
Sbjct: 1536 KKQVEQE-----KCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590

Query: 193  TGEAG------GPPSTREAELKLRLKLVEEEANILGRKIVELEVE-NRGLKAEMEDMRGQ 245
              +           ST +AE++ R   +  +  + G  + E+E++ N   +   E +R  
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG-DLNEMEIQLNHANRMAAEALRNY 1649

Query: 246  QEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHE 305
            +  +G  +D    +      D+L S  +L+  L  VE  A LL+  I E+     Q    
Sbjct: 1650 RNTQGILKDTQIHLD-----DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQT--- 1701

Query: 306  LSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSN 365
                                         +   K A  ++ + S +V  L  +N +L++ 
Sbjct: 1702 -----------------------------ERSRKIAEQELLDASERVQLLHTQNTSLINT 1732

Query: 366  IQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKT 425
             ++ +              +D     G+ E   +E+R  + K +  +   +   E  +K 
Sbjct: 1733 KKKLE--------------TDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKE 1778

Query: 426  SGFGSG--KPSEASEPCPTELLKAREDSEYLVTL--KHEAQRLERTVERLITDTDSFLHD 481
                +   +  +  E    +L    +++E L     K + Q+LE  V  L  + +S    
Sbjct: 1779 QDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKR 1838

Query: 482  -----AGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVN 534
                  GLR             EE  +   +   L+  + AK+K++K++ +   EQ N
Sbjct: 1839 NAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1896



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 175/1001 (17%), Positives = 383/1001 (38%), Gaps = 168/1001 (16%)

Query: 15   QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVR 74
            +  EL++++D        ++      E K   + E      E I  L ++ K  ++   +
Sbjct: 952  ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011

Query: 75   LHHELKTVEEK-----------RAKAEDENETLRQQM---IEVEISKQALQNELERLKES 120
               +L+  E+K             + +D   +L Q+    +++E +K+ L+ +L+  +ES
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071

Query: 121  SLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKY 180
             +   + ++   EK    + + ++L+ +++  +     ++KK+ +L    +ELE+E++  
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE 1131

Query: 181  KSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKI---VELEVENRGLKA 237
            ++            +A    S    EL+   + +EE       +I    + E E + ++ 
Sbjct: 1132 RA---------SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1182

Query: 238  EMEDMRGQQEREGP--GRDHAPSIPTSPFGDSLES-----------STELRRHLQFVEEE 284
            ++E+   Q E       + HA S+  +  G+ +++            +E++  +  +   
Sbjct: 1183 DLEEATLQHEATAATLRKKHADSV--AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN 1240

Query: 285  AELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQ 344
             E + ++   +E   R L  +LS+ K +   +   + +  +        LQ E      Q
Sbjct: 1241 VETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQ----RGRLQTESGEFSRQ 1296

Query: 345  ISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSP-----RDSDAESDAGKKESDGE 399
            + E    V +L     A    I+         ++A +      + S  + D  +++ + E
Sbjct: 1297 LDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEE 1356

Query: 400  -ESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLK 458
             ES+    +       E        +T      +  E ++    + L+A E  E++  + 
Sbjct: 1357 QESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAE--EHVEAVN 1414

Query: 459  HEAQRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAK 518
             +   LE+T +RL  + +  + D      A         +++Q   D    ++L     K
Sbjct: 1415 AKCASLEKTKQRLQNEVEDLMLDVERTNAA-----CAALDKKQRNFD----KILAEWKQK 1465

Query: 519  MKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQS 578
             +    EL+A  ++   +G  L  + +  E S  L  + ++ R++   NL +E+  DL  
Sbjct: 1466 CEETHAELEASQKEARSLGTELFKIKNAYEES--LDQLETLKRENK--NLQQEIS-DLTE 1520

Query: 579  RLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPE 638
            ++ E      G  R  E E ++ +  +E                      EL+    L E
Sbjct: 1521 QIAE------GGKRIHELEKIKKQVEQE--------------------KCELQA--ALEE 1552

Query: 639  QSVSIEELQGQLVQ-AARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHE 697
               S+E  +G++++    L+Q ++E    KI + +EE              +      H 
Sbjct: 1553 AEASLEHEEGKILRIQLELNQVKSEV-DRKIAEKDEE--------------IDQLKRNHI 1597

Query: 698  RTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRL 757
            R     ++ +  E+RS    I              R  K+ME +               L
Sbjct: 1598 RIVESMQSTLDAEIRSRNDAI--------------RLKKKMEGD---------------L 1628

Query: 758  GELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQP--HKQVVE 815
             E+ +Q  H        ++R     +  +  +++  + D  + L  A R Q    +Q+  
Sbjct: 1629 NEMEIQLNH--------ANRMAAEALRNYR-NTQGILKDTQIHLDDALRSQEDLKEQLAM 1679

Query: 816  NQQLFSAFKALLEDFRAELREDERARLRLQQQY--ASDKA----AWDVEWAVLKCRLEQL 869
             ++  +  +A +E+ RA L + ER+R   +Q+   AS++       +      K +LE  
Sbjct: 1680 VERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD 1739

Query: 870  EEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVEL 929
              + + ++ ++   A +     K+      ++A+      D    +   +KN  +   +L
Sbjct: 1740 ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDL 1799

Query: 930  LDRLD-----------RDRQEWERQKKEFLWRIEQLQKENS 959
              RLD           +  Q+ E + +E    +E  QK N+
Sbjct: 1800 QLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNA 1840



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 65/308 (21%), Positives = 126/308 (40%), Gaps = 42/308 (13%)

Query: 102  EVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRK 161
            E E     ++ E +++K+   K  + R+  +EK      +  DL+ Q+Q   E      +
Sbjct: 850  ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909

Query: 162  KMAKLGREKDELEQELQKYKSLYGD---VDSPLPTGEAGGPPSTREA-----ELKLRLKL 213
            +  +L + K +LE ++++      D   +++ L   +        E      +L+L L  
Sbjct: 910  RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 969

Query: 214  VEEEANILGRKIVELEVENRGL------------------KAEMEDMRGQQEREGPGRDH 255
            VE+E +    K+  L  E  GL                  +  ++D++ ++++       
Sbjct: 970  VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT-- 1027

Query: 256  APSIPTSPFGDSLESSTELRRHLQF--------VEEEAELLRRSISEIEDHNRQLTHELS 307
               I      D LE S E  + L+         +E + +L + SI +IE+  +QL  +L 
Sbjct: 1028 KAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLK 1087

Query: 308  KFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQ 367
            K +FE       L          G  LQ+++K  + +I EL  ++ + +  + A     Q
Sbjct: 1088 KKEFEISN----LQSKIEDEQALGIQLQKKIKELQARIEELEEEI-EAERASRAKAEK-Q 1141

Query: 368  RCDLAAHL 375
            R DL+  L
Sbjct: 1142 RSDLSREL 1149



 Score = 32.7 bits (73), Expect = 2.9
 Identities = 80/353 (22%), Positives = 142/353 (40%), Gaps = 40/353 (11%)

Query: 142  SADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPS 201
            SA+   ++   KEE   ++ ++AK   ++ ELE+++        D+   +   EA G   
Sbjct: 848  SAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV-QAEAEGLAD 906

Query: 202  TRE---------AELKLRLKLV------EEEANI-LGRKIVELEVENRGLKAEMEDMR-- 243
              E          +L+ ++K V      EEE N  L  K  +LE E   LK +++D+   
Sbjct: 907  AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 966

Query: 244  -GQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQL 302
              + E+E    ++     T       E+  +L +  + ++E  +     +   ED    L
Sbjct: 967  LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026

Query: 303  THELSKFKFEPPREPGWLG---------EGASPGAGGGAPL-QEELKSARLQISELSGKV 352
            T    K + +     G L          E A     G   L QE +     +  +L  K+
Sbjct: 1027 TKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKL 1086

Query: 353  LKLQHENHALLSNIQ-RCDLAAHLGLRAPSP-RDSDAESDAGKKESDGEE-SRLPQPKRE 409
             K + E    +SN+Q + +    LG++     ++  A  +  ++E + E  SR    K+ 
Sbjct: 1087 KKKEFE----ISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1142

Query: 410  GPVGGE-SDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEA 461
              +  E  +  E  E+  G  S +  E ++    E  K R D E   TL+HEA
Sbjct: 1143 SDLSRELEEISERLEEAGGATSAQ-IEMNKKREAEFQKMRRDLEE-ATLQHEA 1193


>gi|22749429 coiled-coil domain containing 89 [Homo sapiens]
          Length = 374

 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 80/322 (24%), Positives = 133/322 (41%), Gaps = 51/322 (15%)

Query: 4   MRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQ 63
           M  S +EE    +  L+R  D A + C+IL+    + E+K ++ AE  +  GE  R LE+
Sbjct: 65  MLRSRIEEQSQLICILKRRSDEALERCQILELLNAELEEKMMQEAEKLKAQGEYSRKLEE 124

Query: 64  ---DLKVAKDVSVRLHHELKT----VEEKRAKAEDENETLRQQMIEVEISK--------Q 108
               L    ++ +R   E K+    + E+  K   EN +L  Q ++ E +K        +
Sbjct: 125 RFMTLAANHELMLRFKDEYKSENIKLREENEKLRLENSSLFSQALKDEEAKVLQLTVRCE 184

Query: 109 ALQNELERLKE--------SSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMR 160
           AL  ELE LKE        +  + +   E+  ++   +  ++  LR QLQ  K++     
Sbjct: 185 ALTGELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQTLKQQHQQAV 244

Query: 161 KKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANI 220
           +++AK       L QELQ                 A     TRE E  L+L +  E   +
Sbjct: 245 EQIAKAEETHSSLSQELQ-----------------ARLQTVTREKEELLQLSI--ERGKV 285

Query: 221 LGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQF 280
           L  K  E+      L+   ED +   ER       A ++      DS     EL+R +  
Sbjct: 286 LQNKQAEICQLEEKLEIANEDRKHALER---FEQEAVAV------DSNLRVRELQRKVDG 336

Query: 281 VEEEAELLRRSISEIEDHNRQL 302
           +++  + LR      + H+  L
Sbjct: 337 IQKAYDELRLQSEAFKKHSLDL 358


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 129/588 (21%), Positives = 241/588 (40%), Gaps = 84/588 (14%)

Query: 7    SYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLK 66
            S  E  ++  QEL +E  RA      L  R+R  E ++  + E  + +        ++L+
Sbjct: 1336 SSTEAQLHDAQELLQEETRAKL---ALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQ 1392

Query: 67   VAK----DVSVRLHHE---LKTVEEKRAKAEDENETLRQQMIE-------VEISKQALQN 112
             A+    +   R   E   L+  EE R +A  E E L Q++ E       +E  ++ LQ 
Sbjct: 1393 TAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ 1452

Query: 113  ELE-RLKESSLKRRSTREMYKEKKTFNQ----DDSADLRCQLQFAKEEAFLMRKKMAKLG 167
            EL+    +   +R+    + K+++ F+Q    + +A LR   +  + EA    ++   L 
Sbjct: 1453 ELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALS 1512

Query: 168  -----REKDELEQELQKY-KSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANIL 221
                  E+ E  +EL++  ++L  ++++ L + +  G       EL+   ++ E+ AN L
Sbjct: 1513 LTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH---ELERACRVAEQAANDL 1569

Query: 222  GRKIVELEVENRG-------LKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTEL 274
              ++ ELE E          L+  ++ ++ Q ER+  GRD A            E   +L
Sbjct: 1570 RAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGE----------ERRRQL 1619

Query: 275  RRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPL 334
             + L+  E E +  R+  +      ++L  EL + K           + AS G G    +
Sbjct: 1620 AKQLRDAEVERDEERKQRTLAVAARKKLEGELEELK----------AQMASAGQGKEEAV 1669

Query: 335  QEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSD--AESDAG 392
            ++ L+  + Q+ EL  +V + +     + S  +  +     GL A   R  +  A SD  
Sbjct: 1670 KQ-LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK-GLEAEVLRLQEELAASDRA 1727

Query: 393  KKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTELLKARE--- 449
            ++++  +   +      G +   +  EE  +     G  +     E   +ELL  R    
Sbjct: 1728 RRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKL 1787

Query: 450  -----------DSEYLVTLKHEA--QRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQ 496
                        +E   + K E+  Q+LER ++ L         DAG R    +    L+
Sbjct: 1788 LLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGE--EDAGARARHKMTIAALE 1845

Query: 497  GE----EEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGL 540
             +    EEQ E + +E  L G +  + +   KE+   +E+  R+ D L
Sbjct: 1846 SKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQL 1893



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 207/980 (21%), Positives = 367/980 (37%), Gaps = 120/980 (12%)

Query: 37   LRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETL 96
            L+   Q+  KV E  Q     +  L+  +   ++   RL  +L+   E  A+AE+    L
Sbjct: 879  LQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRL 938

Query: 97   RQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEA 156
              +  E+E+    L+  +   +E S      R+M  EKK          R Q    + EA
Sbjct: 939  AARKQELELVVSELEARVGEEEECS------RQMQTEKK----------RLQQHIQELEA 982

Query: 157  FLMRKKMA--KLGREKDELEQELQKYKS---LYGDVDSPLPTGEAGGPPSTREAELKLRL 211
             L  ++ A  KL  EK   E +++K++    L  D +S L         S     L+ RL
Sbjct: 983  HLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKL---------SKERKLLEDRL 1033

Query: 212  KLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESS 271
                 +A     K+  L       +A + DM  +  +E  GR     +     G+    S
Sbjct: 1034 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGE----S 1089

Query: 272  TELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGG 331
            +EL+  +   ++ AE LR  +   E+   +L   L++ + E       L +         
Sbjct: 1090 SELQEQMVEQQQRAEELRAQLGRKEE---ELQAALARAEDEGGARAQLL-KSLREAQAAL 1145

Query: 332  APLQEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDA 391
            A  QE+L+S R+  ++   +   L  E  AL   ++    + +      S R+ +     
Sbjct: 1146 AEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE-- 1203

Query: 392  GKKESDGEESRLPQP------KREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTELL 445
              K++  EE+R+ +       +R G   GE  +E++ +   G G+ + +  +     E+ 
Sbjct: 1204 -LKKTLEEETRIHEAAVQELRQRHGQALGEL-AEQLEQARRGKGAWEKTRLA--LEAEVS 1259

Query: 446  KAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDA-GLRGGAPLPGPGLQGEEEQGEG 504
            + R +   L T + E ++  R +E  + +      D    R  A       Q E E   G
Sbjct: 1260 ELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSG 1319

Query: 505  DQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSP 564
               E +      +K     KEL +   Q++   D    L   T +   L +         
Sbjct: 1320 ALNEAE------SKTIRLSKELSSTEAQLH---DAQELLQEETRAKLALGSRVRAMEAEA 1370

Query: 565  IG---NLGKE------LGPDLQSRLKEQLEWQLGPARGDERESLRLRAARELHRR----A 611
             G    L +E       G +LQ+   +  EW+    R  E E+  L A  E  RR    A
Sbjct: 1371 AGLREQLEEEAAARERAGRELQTAQAQLSEWR----RRQEEEAGALEAGEEARRRAAREA 1426

Query: 612  DGDTGSHGLGGQTCFSLE---LRGPPVLPEQSVSIEELQGQLVQAARLHQEE-----TET 663
            +  T       +T   LE    R    L + ++ +E+ Q QLV      Q +      E 
Sbjct: 1427 EALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQ-QRQLVSTLEKKQRKFDQLLAEE 1485

Query: 664  FTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEK-----NLMQQELRSLKQNI 718
                +  +EE        +E E  +L+L   L E   + E+       ++ EL +L  + 
Sbjct: 1486 KAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSK 1545

Query: 719  FLFYVKLRWLLKHWRQGKQMEEE-GEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDR 777
                  +  L +  R  +Q   +   + TE E   T +   +L ++   QA    H+ D 
Sbjct: 1546 DDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDL 1605

Query: 778  GCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFSAFKALLEDFRAEL--- 834
                  GE     R Q+    LR    +R +  KQ           +  LE+ +A++   
Sbjct: 1606 QGRDEAGE---ERRRQLA-KQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASA 1661

Query: 835  -REDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELGSSAESKGALKKE 893
             +  E A  +L++  A  K  W     V + R  + E  ++N+     S    KG   + 
Sbjct: 1662 GQGKEEAVKQLRKMQAQMKELWR---EVEETRTSREEIFSQNR----ESEKRLKGLEAEV 1714

Query: 894  REVHQKLLADSHS--LVMDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRI 951
              + ++L A   +       R ++     N N  K  +L+           +K++   R+
Sbjct: 1715 LRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE-----------EKRQLEGRL 1763

Query: 952  EQLQKENSPRRGGSFLCDQK 971
             QL++E    +  S L + +
Sbjct: 1764 GQLEEELEEEQSNSELLNDR 1783



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 215/1077 (19%), Positives = 395/1077 (36%), Gaps = 218/1077 (20%)

Query: 33   LQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAK---- 88
            L+ R+ + E+ S ++    +   + I+ LE  L+  +    +L  E  T E K  K    
Sbjct: 952  LEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEED 1011

Query: 89   ---AEDENETL--RQQMIE---VEISKQALQNE--LERLKESSLKRRST----------- 127
                ED+N  L   ++++E    E S QA + E  ++ L +  LK  +T           
Sbjct: 1012 LLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKE 1071

Query: 128  ---REMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLY 184
               R+  ++ K     +S++L+ Q+   ++ A  +R   A+LGR+++EL+  L + +   
Sbjct: 1072 EKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR---AQLGRKEEELQAALARAEDEG 1128

Query: 185  GDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRG 244
            G          A    S REA+  L     + E+  + R   + E + R L  E+E +RG
Sbjct: 1129 G--------ARAQLLKSLREAQAALAEAQEDLESERVAR--TKAEKQRRDLGEELEALRG 1178

Query: 245  QQE--------------------------REGPGRDHAPSIPT------SPFGDSLESST 272
            + E                           E   R H  ++           G+  E   
Sbjct: 1179 ELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLE 1238

Query: 273  ELRR-------HLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGAS 325
            + RR           +E E   LR  +S ++   ++      + + +     G  G+G  
Sbjct: 1239 QARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGER 1298

Query: 326  PGAGGGAPLQE---ELKSARLQISELSGKVLKLQ----------HENHALLSNIQRCDLA 372
              A     LQ    EL++    ++E   K ++L           H+   LL    R  LA
Sbjct: 1299 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLA 1358

Query: 373  AHLGLRAPSPRDS----DAESDAGKKESDGEESRLPQP-------KREGPVGGESDSEEM 421
                +RA     +      E +A  +E  G E +  Q        ++E   G     EE 
Sbjct: 1359 LGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEA 1418

Query: 422  FEKTSGFGSGKPSEASEPCPT-------------ELLKAREDSEYLVTLKHEAQRLERTV 468
              + +          +E   T             EL  A  D E    L    ++ +R  
Sbjct: 1419 RRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKF 1478

Query: 469  ERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQG------EGDQQEPQLLGTINAKMKAF 522
            ++L+ +  +    A LR          +G E +          ++E +    +  + +A 
Sbjct: 1479 DQLLAEEKA----AVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRAL 1534

Query: 523  KKELQAFLEQVNRIGDGLSPLPHLTE-----SSSFLSTVTSVSRDSPIGNLGKELGPDLQ 577
            + EL+A L   + +G  +  L          ++   + VT +  +       K       
Sbjct: 1535 RAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTV 1594

Query: 578  SRLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLP 637
              LK Q E  L   R +  E  R + A++L    D +        Q   ++  R      
Sbjct: 1595 QALKTQHERDL-QGRDEAGEERRRQLAKQLR---DAEVERDEERKQRTLAVAAR-----K 1645

Query: 638  EQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHE 697
            +    +EEL+ Q+  A +  +E  +       +M+E       W+E+E        T  E
Sbjct: 1646 KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE------LWREVEE-----TRTSRE 1694

Query: 698  RTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQ-MEEEGEEFTEG-------- 748
              +S  +   ++ L+ L+  +     +L    +  RQ +Q  +E  +E   G        
Sbjct: 1695 EIFSQNRE-SEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAIL 1753

Query: 749  -EHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQ-TADR 806
             E  +   RLG+L  +   +    +  +DR           + ++ +   SL  + +A+R
Sbjct: 1754 EEKRQLEGRLGQLEEELEEEQSNSELLNDR-----------YRKLLLQVESLTTELSAER 1802

Query: 807  GQPHKQVVENQQLFSAFKALLEDFRAEL-REDERARLRLQQQYASDKAAWDVEWAVLKCR 865
                           +F A  E  R +L R+ +  R RL ++ A  +A   +  A L+ +
Sbjct: 1803 ---------------SFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESK 1847

Query: 866  L----EQLEEKTENKL--GELGSSAESK-----GALKKEREVHQKL---LADSHSLVMDL 911
            L    EQLE++T  ++  G+L   AE +       +++ER V  +L   L   +  V  L
Sbjct: 1848 LAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQL 1907

Query: 912  RWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQKE-----NSPRRG 963
            + Q+  +E        E   R    R+  +R+ ++     E + +E     N  RRG
Sbjct: 1908 KRQLEEAE--------EEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRG 1956



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 76/350 (21%), Positives = 139/350 (39%), Gaps = 80/350 (22%)

Query: 15   QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQD---------- 64
            +++E R   +      R  + RL+  E + L++ E         R  +QD          
Sbjct: 1685 EVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVAN 1744

Query: 65   --------LKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELER 116
                    L+  + +  RL    + +EE+++ +E  N+  R+ +++VE    +L  EL  
Sbjct: 1745 GNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVE----SLTTELSA 1800

Query: 117  LKESSLKRRSTREMYKEK------KTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREK 170
             +  S K  S R+  + +      +   +D  A  R ++  A  E        +KL + +
Sbjct: 1801 ERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALE--------SKLAQAE 1852

Query: 171  DELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLR--LKLVEEEANILGRKIVEL 228
            ++LEQE ++ + L G +               R AE +L+  +  VEEE  +  +   +L
Sbjct: 1853 EQLEQETRE-RILSGKL--------------VRRAEKRLKEVVLQVEEERRVADQLRDQL 1897

Query: 229  EVEN---RGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEA 285
            E  N   + LK ++E+   +  R   GR                    L+R L+ V E A
Sbjct: 1898 EKGNLRVKQLKRQLEEAEEEASRAQAGR------------------RRLQRELEDVTESA 1939

Query: 286  ELLRRSISEIEDHNRQ--LTHEL----SKFKFEPPREPGWLGEGASPGAG 329
            E + R ++ + +  R+  LT         F+ E         E A PG+G
Sbjct: 1940 ESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQPGSG 1989


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 129/588 (21%), Positives = 241/588 (40%), Gaps = 84/588 (14%)

Query: 7    SYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLK 66
            S  E  ++  QEL +E  RA      L  R+R  E ++  + E  + +        ++L+
Sbjct: 1328 SSTEAQLHDAQELLQEETRAKL---ALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQ 1384

Query: 67   VAK----DVSVRLHHE---LKTVEEKRAKAEDENETLRQQMIE-------VEISKQALQN 112
             A+    +   R   E   L+  EE R +A  E E L Q++ E       +E  ++ LQ 
Sbjct: 1385 TAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ 1444

Query: 113  ELE-RLKESSLKRRSTREMYKEKKTFNQ----DDSADLRCQLQFAKEEAFLMRKKMAKLG 167
            EL+    +   +R+    + K+++ F+Q    + +A LR   +  + EA    ++   L 
Sbjct: 1445 ELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALS 1504

Query: 168  -----REKDELEQELQKY-KSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANIL 221
                  E+ E  +EL++  ++L  ++++ L + +  G       EL+   ++ E+ AN L
Sbjct: 1505 LTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH---ELERACRVAEQAANDL 1561

Query: 222  GRKIVELEVENRG-------LKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTEL 274
              ++ ELE E          L+  ++ ++ Q ER+  GRD A            E   +L
Sbjct: 1562 RAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGE----------ERRRQL 1611

Query: 275  RRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPL 334
             + L+  E E +  R+  +      ++L  EL + K           + AS G G    +
Sbjct: 1612 AKQLRDAEVERDEERKQRTLAVAARKKLEGELEELK----------AQMASAGQGKEEAV 1661

Query: 335  QEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSD--AESDAG 392
            ++ L+  + Q+ EL  +V + +     + S  +  +     GL A   R  +  A SD  
Sbjct: 1662 KQ-LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK-GLEAEVLRLQEELAASDRA 1719

Query: 393  KKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTELLKARE--- 449
            ++++  +   +      G +   +  EE  +     G  +     E   +ELL  R    
Sbjct: 1720 RRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKL 1779

Query: 450  -----------DSEYLVTLKHEA--QRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQ 496
                        +E   + K E+  Q+LER ++ L         DAG R    +    L+
Sbjct: 1780 LLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGE--EDAGARARHKMTIAALE 1837

Query: 497  GE----EEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGL 540
             +    EEQ E + +E  L G +  + +   KE+   +E+  R+ D L
Sbjct: 1838 SKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQL 1885



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 207/980 (21%), Positives = 367/980 (37%), Gaps = 120/980 (12%)

Query: 37   LRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETL 96
            L+   Q+  KV E  Q     +  L+  +   ++   RL  +L+   E  A+AE+    L
Sbjct: 871  LQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRL 930

Query: 97   RQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEA 156
              +  E+E+    L+  +   +E S      R+M  EKK          R Q    + EA
Sbjct: 931  AARKQELELVVSELEARVGEEEECS------RQMQTEKK----------RLQQHIQELEA 974

Query: 157  FLMRKKMA--KLGREKDELEQELQKYKS---LYGDVDSPLPTGEAGGPPSTREAELKLRL 211
             L  ++ A  KL  EK   E +++K++    L  D +S L         S     L+ RL
Sbjct: 975  HLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKL---------SKERKLLEDRL 1025

Query: 212  KLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESS 271
                 +A     K+  L       +A + DM  +  +E  GR     +     G+    S
Sbjct: 1026 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGE----S 1081

Query: 272  TELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGG 331
            +EL+  +   ++ AE LR  +   E+   +L   L++ + E       L +         
Sbjct: 1082 SELQEQMVEQQQRAEELRAQLGRKEE---ELQAALARAEDEGGARAQLL-KSLREAQAAL 1137

Query: 332  APLQEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDA 391
            A  QE+L+S R+  ++   +   L  E  AL   ++    + +      S R+ +     
Sbjct: 1138 AEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE-- 1195

Query: 392  GKKESDGEESRLPQP------KREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTELL 445
              K++  EE+R+ +       +R G   GE  +E++ +   G G+ + +  +     E+ 
Sbjct: 1196 -LKKTLEEETRIHEAAVQELRQRHGQALGEL-AEQLEQARRGKGAWEKTRLA--LEAEVS 1251

Query: 446  KAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDA-GLRGGAPLPGPGLQGEEEQGEG 504
            + R +   L T + E ++  R +E  + +      D    R  A       Q E E   G
Sbjct: 1252 ELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSG 1311

Query: 505  DQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSP 564
               E +      +K     KEL +   Q++   D    L   T +   L +         
Sbjct: 1312 ALNEAE------SKTIRLSKELSSTEAQLH---DAQELLQEETRAKLALGSRVRAMEAEA 1362

Query: 565  IG---NLGKE------LGPDLQSRLKEQLEWQLGPARGDERESLRLRAARELHRR----A 611
             G    L +E       G +LQ+   +  EW+    R  E E+  L A  E  RR    A
Sbjct: 1363 AGLREQLEEEAAARERAGRELQTAQAQLSEWR----RRQEEEAGALEAGEEARRRAAREA 1418

Query: 612  DGDTGSHGLGGQTCFSLE---LRGPPVLPEQSVSIEELQGQLVQAARLHQEE-----TET 663
            +  T       +T   LE    R    L + ++ +E+ Q QLV      Q +      E 
Sbjct: 1419 EALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQ-QRQLVSTLEKKQRKFDQLLAEE 1477

Query: 664  FTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEK-----NLMQQELRSLKQNI 718
                +  +EE        +E E  +L+L   L E   + E+       ++ EL +L  + 
Sbjct: 1478 KAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSK 1537

Query: 719  FLFYVKLRWLLKHWRQGKQMEEE-GEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDR 777
                  +  L +  R  +Q   +   + TE E   T +   +L ++   QA    H+ D 
Sbjct: 1538 DDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDL 1597

Query: 778  GCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFSAFKALLEDFRAEL--- 834
                  GE     R Q+    LR    +R +  KQ           +  LE+ +A++   
Sbjct: 1598 QGRDEAGE---ERRRQLA-KQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASA 1653

Query: 835  -REDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELGSSAESKGALKKE 893
             +  E A  +L++  A  K  W     V + R  + E  ++N+     S    KG   + 
Sbjct: 1654 GQGKEEAVKQLRKMQAQMKELWR---EVEETRTSREEIFSQNR----ESEKRLKGLEAEV 1706

Query: 894  REVHQKLLADSHS--LVMDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRI 951
              + ++L A   +       R ++     N N  K  +L+           +K++   R+
Sbjct: 1707 LRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE-----------EKRQLEGRL 1755

Query: 952  EQLQKENSPRRGGSFLCDQK 971
             QL++E    +  S L + +
Sbjct: 1756 GQLEEELEEEQSNSELLNDR 1775



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 215/1077 (19%), Positives = 395/1077 (36%), Gaps = 218/1077 (20%)

Query: 33   LQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAK---- 88
            L+ R+ + E+ S ++    +   + I+ LE  L+  +    +L  E  T E K  K    
Sbjct: 944  LEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEED 1003

Query: 89   ---AEDENETL--RQQMIE---VEISKQALQNE--LERLKESSLKRRST----------- 127
                ED+N  L   ++++E    E S QA + E  ++ L +  LK  +T           
Sbjct: 1004 LLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKE 1063

Query: 128  ---REMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLY 184
               R+  ++ K     +S++L+ Q+   ++ A  +R   A+LGR+++EL+  L + +   
Sbjct: 1064 EKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR---AQLGRKEEELQAALARAEDEG 1120

Query: 185  GDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRG 244
            G          A    S REA+  L     + E+  + R   + E + R L  E+E +RG
Sbjct: 1121 G--------ARAQLLKSLREAQAALAEAQEDLESERVAR--TKAEKQRRDLGEELEALRG 1170

Query: 245  QQE--------------------------REGPGRDHAPSIPT------SPFGDSLESST 272
            + E                           E   R H  ++           G+  E   
Sbjct: 1171 ELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLE 1230

Query: 273  ELRR-------HLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGAS 325
            + RR           +E E   LR  +S ++   ++      + + +     G  G+G  
Sbjct: 1231 QARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGER 1290

Query: 326  PGAGGGAPLQE---ELKSARLQISELSGKVLKLQ----------HENHALLSNIQRCDLA 372
              A     LQ    EL++    ++E   K ++L           H+   LL    R  LA
Sbjct: 1291 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLA 1350

Query: 373  AHLGLRAPSPRDS----DAESDAGKKESDGEESRLPQP-------KREGPVGGESDSEEM 421
                +RA     +      E +A  +E  G E +  Q        ++E   G     EE 
Sbjct: 1351 LGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEA 1410

Query: 422  FEKTSGFGSGKPSEASEPCPT-------------ELLKAREDSEYLVTLKHEAQRLERTV 468
              + +          +E   T             EL  A  D E    L    ++ +R  
Sbjct: 1411 RRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKF 1470

Query: 469  ERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQG------EGDQQEPQLLGTINAKMKAF 522
            ++L+ +  +    A LR          +G E +          ++E +    +  + +A 
Sbjct: 1471 DQLLAEEKA----AVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRAL 1526

Query: 523  KKELQAFLEQVNRIGDGLSPLPHLTE-----SSSFLSTVTSVSRDSPIGNLGKELGPDLQ 577
            + EL+A L   + +G  +  L          ++   + VT +  +       K       
Sbjct: 1527 RAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTV 1586

Query: 578  SRLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLP 637
              LK Q E  L   R +  E  R + A++L    D +        Q   ++  R      
Sbjct: 1587 QALKTQHERDL-QGRDEAGEERRRQLAKQLR---DAEVERDEERKQRTLAVAAR-----K 1637

Query: 638  EQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHE 697
            +    +EEL+ Q+  A +  +E  +       +M+E       W+E+E        T  E
Sbjct: 1638 KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE------LWREVEE-----TRTSRE 1686

Query: 698  RTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQ-MEEEGEEFTEG-------- 748
              +S  +   ++ L+ L+  +     +L    +  RQ +Q  +E  +E   G        
Sbjct: 1687 EIFSQNRE-SEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAIL 1745

Query: 749  -EHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQ-TADR 806
             E  +   RLG+L  +   +    +  +DR           + ++ +   SL  + +A+R
Sbjct: 1746 EEKRQLEGRLGQLEEELEEEQSNSELLNDR-----------YRKLLLQVESLTTELSAER 1794

Query: 807  GQPHKQVVENQQLFSAFKALLEDFRAEL-REDERARLRLQQQYASDKAAWDVEWAVLKCR 865
                           +F A  E  R +L R+ +  R RL ++ A  +A   +  A L+ +
Sbjct: 1795 ---------------SFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESK 1839

Query: 866  L----EQLEEKTENKL--GELGSSAESK-----GALKKEREVHQKL---LADSHSLVMDL 911
            L    EQLE++T  ++  G+L   AE +       +++ER V  +L   L   +  V  L
Sbjct: 1840 LAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQL 1899

Query: 912  RWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQKE-----NSPRRG 963
            + Q+  +E        E   R    R+  +R+ ++     E + +E     N  RRG
Sbjct: 1900 KRQLEEAE--------EEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRG 1948



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 76/350 (21%), Positives = 139/350 (39%), Gaps = 80/350 (22%)

Query: 15   QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQD---------- 64
            +++E R   +      R  + RL+  E + L++ E         R  +QD          
Sbjct: 1677 EVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVAN 1736

Query: 65   --------LKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELER 116
                    L+  + +  RL    + +EE+++ +E  N+  R+ +++VE    +L  EL  
Sbjct: 1737 GNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVE----SLTTELSA 1792

Query: 117  LKESSLKRRSTREMYKEK------KTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREK 170
             +  S K  S R+  + +      +   +D  A  R ++  A  E        +KL + +
Sbjct: 1793 ERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALE--------SKLAQAE 1844

Query: 171  DELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLR--LKLVEEEANILGRKIVEL 228
            ++LEQE ++ + L G +               R AE +L+  +  VEEE  +  +   +L
Sbjct: 1845 EQLEQETRE-RILSGKL--------------VRRAEKRLKEVVLQVEEERRVADQLRDQL 1889

Query: 229  EVEN---RGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEA 285
            E  N   + LK ++E+   +  R   GR                    L+R L+ V E A
Sbjct: 1890 EKGNLRVKQLKRQLEEAEEEASRAQAGR------------------RRLQRELEDVTESA 1931

Query: 286  ELLRRSISEIEDHNRQ--LTHEL----SKFKFEPPREPGWLGEGASPGAG 329
            E + R ++ + +  R+  LT         F+ E         E A PG+G
Sbjct: 1932 ESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQPGSG 1981


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 129/588 (21%), Positives = 241/588 (40%), Gaps = 84/588 (14%)

Query: 7    SYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLK 66
            S  E  ++  QEL +E  RA      L  R+R  E ++  + E  + +        ++L+
Sbjct: 1369 SSTEAQLHDAQELLQEETRAKL---ALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQ 1425

Query: 67   VAK----DVSVRLHHE---LKTVEEKRAKAEDENETLRQQMIE-------VEISKQALQN 112
             A+    +   R   E   L+  EE R +A  E E L Q++ E       +E  ++ LQ 
Sbjct: 1426 TAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ 1485

Query: 113  ELE-RLKESSLKRRSTREMYKEKKTFNQ----DDSADLRCQLQFAKEEAFLMRKKMAKLG 167
            EL+    +   +R+    + K+++ F+Q    + +A LR   +  + EA    ++   L 
Sbjct: 1486 ELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALS 1545

Query: 168  -----REKDELEQELQKY-KSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANIL 221
                  E+ E  +EL++  ++L  ++++ L + +  G       EL+   ++ E+ AN L
Sbjct: 1546 LTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH---ELERACRVAEQAANDL 1602

Query: 222  GRKIVELEVENRG-------LKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTEL 274
              ++ ELE E          L+  ++ ++ Q ER+  GRD A            E   +L
Sbjct: 1603 RAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGE----------ERRRQL 1652

Query: 275  RRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPL 334
             + L+  E E +  R+  +      ++L  EL + K           + AS G G    +
Sbjct: 1653 AKQLRDAEVERDEERKQRTLAVAARKKLEGELEELK----------AQMASAGQGKEEAV 1702

Query: 335  QEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSD--AESDAG 392
            ++ L+  + Q+ EL  +V + +     + S  +  +     GL A   R  +  A SD  
Sbjct: 1703 KQ-LRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK-GLEAEVLRLQEELAASDRA 1760

Query: 393  KKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTELLKARE--- 449
            ++++  +   +      G +   +  EE  +     G  +     E   +ELL  R    
Sbjct: 1761 RRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKL 1820

Query: 450  -----------DSEYLVTLKHEA--QRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQ 496
                        +E   + K E+  Q+LER ++ L         DAG R    +    L+
Sbjct: 1821 LLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGE--EDAGARARHKMTIAALE 1878

Query: 497  GE----EEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGL 540
             +    EEQ E + +E  L G +  + +   KE+   +E+  R+ D L
Sbjct: 1879 SKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQL 1926



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 207/980 (21%), Positives = 367/980 (37%), Gaps = 120/980 (12%)

Query: 37   LRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETL 96
            L+   Q+  KV E  Q     +  L+  +   ++   RL  +L+   E  A+AE+    L
Sbjct: 912  LQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRL 971

Query: 97   RQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEA 156
              +  E+E+    L+  +   +E S      R+M  EKK          R Q    + EA
Sbjct: 972  AARKQELELVVSELEARVGEEEECS------RQMQTEKK----------RLQQHIQELEA 1015

Query: 157  FLMRKKMA--KLGREKDELEQELQKYKS---LYGDVDSPLPTGEAGGPPSTREAELKLRL 211
             L  ++ A  KL  EK   E +++K++    L  D +S L         S     L+ RL
Sbjct: 1016 HLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKL---------SKERKLLEDRL 1066

Query: 212  KLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESS 271
                 +A     K+  L       +A + DM  +  +E  GR     +     G+    S
Sbjct: 1067 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGE----S 1122

Query: 272  TELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGG 331
            +EL+  +   ++ AE LR  +   E+   +L   L++ + E       L +         
Sbjct: 1123 SELQEQMVEQQQRAEELRAQLGRKEE---ELQAALARAEDEGGARAQLL-KSLREAQAAL 1178

Query: 332  APLQEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDA 391
            A  QE+L+S R+  ++   +   L  E  AL   ++    + +      S R+ +     
Sbjct: 1179 AEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE-- 1236

Query: 392  GKKESDGEESRLPQP------KREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTELL 445
              K++  EE+R+ +       +R G   GE  +E++ +   G G+ + +  +     E+ 
Sbjct: 1237 -LKKTLEEETRIHEAAVQELRQRHGQALGEL-AEQLEQARRGKGAWEKTRLA--LEAEVS 1292

Query: 446  KAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDA-GLRGGAPLPGPGLQGEEEQGEG 504
            + R +   L T + E ++  R +E  + +      D    R  A       Q E E   G
Sbjct: 1293 ELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSG 1352

Query: 505  DQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSP 564
               E +      +K     KEL +   Q++   D    L   T +   L +         
Sbjct: 1353 ALNEAE------SKTIRLSKELSSTEAQLH---DAQELLQEETRAKLALGSRVRAMEAEA 1403

Query: 565  IG---NLGKE------LGPDLQSRLKEQLEWQLGPARGDERESLRLRAARELHRR----A 611
             G    L +E       G +LQ+   +  EW+    R  E E+  L A  E  RR    A
Sbjct: 1404 AGLREQLEEEAAARERAGRELQTAQAQLSEWR----RRQEEEAGALEAGEEARRRAAREA 1459

Query: 612  DGDTGSHGLGGQTCFSLE---LRGPPVLPEQSVSIEELQGQLVQAARLHQEE-----TET 663
            +  T       +T   LE    R    L + ++ +E+ Q QLV      Q +      E 
Sbjct: 1460 EALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQ-QRQLVSTLEKKQRKFDQLLAEE 1518

Query: 664  FTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEK-----NLMQQELRSLKQNI 718
                +  +EE        +E E  +L+L   L E   + E+       ++ EL +L  + 
Sbjct: 1519 KAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSK 1578

Query: 719  FLFYVKLRWLLKHWRQGKQMEEE-GEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDR 777
                  +  L +  R  +Q   +   + TE E   T +   +L ++   QA    H+ D 
Sbjct: 1579 DDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDL 1638

Query: 778  GCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFSAFKALLEDFRAEL--- 834
                  GE     R Q+    LR    +R +  KQ           +  LE+ +A++   
Sbjct: 1639 QGRDEAGE---ERRRQLA-KQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASA 1694

Query: 835  -REDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELGSSAESKGALKKE 893
             +  E A  +L++  A  K  W     V + R  + E  ++N+     S    KG   + 
Sbjct: 1695 GQGKEEAVKQLRKMQAQMKELWR---EVEETRTSREEIFSQNR----ESEKRLKGLEAEV 1747

Query: 894  REVHQKLLADSHS--LVMDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRI 951
              + ++L A   +       R ++     N N  K  +L+           +K++   R+
Sbjct: 1748 LRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE-----------EKRQLEGRL 1796

Query: 952  EQLQKENSPRRGGSFLCDQK 971
             QL++E    +  S L + +
Sbjct: 1797 GQLEEELEEEQSNSELLNDR 1816



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 215/1077 (19%), Positives = 395/1077 (36%), Gaps = 218/1077 (20%)

Query: 33   LQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAK---- 88
            L+ R+ + E+ S ++    +   + I+ LE  L+  +    +L  E  T E K  K    
Sbjct: 985  LEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEED 1044

Query: 89   ---AEDENETL--RQQMIE---VEISKQALQNE--LERLKESSLKRRST----------- 127
                ED+N  L   ++++E    E S QA + E  ++ L +  LK  +T           
Sbjct: 1045 LLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKE 1104

Query: 128  ---REMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLY 184
               R+  ++ K     +S++L+ Q+   ++ A  +R   A+LGR+++EL+  L + +   
Sbjct: 1105 EKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR---AQLGRKEEELQAALARAEDEG 1161

Query: 185  GDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRG 244
            G          A    S REA+  L     + E+  + R   + E + R L  E+E +RG
Sbjct: 1162 G--------ARAQLLKSLREAQAALAEAQEDLESERVAR--TKAEKQRRDLGEELEALRG 1211

Query: 245  QQE--------------------------REGPGRDHAPSIPT------SPFGDSLESST 272
            + E                           E   R H  ++           G+  E   
Sbjct: 1212 ELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLE 1271

Query: 273  ELRR-------HLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGAS 325
            + RR           +E E   LR  +S ++   ++      + + +     G  G+G  
Sbjct: 1272 QARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGER 1331

Query: 326  PGAGGGAPLQE---ELKSARLQISELSGKVLKLQ----------HENHALLSNIQRCDLA 372
              A     LQ    EL++    ++E   K ++L           H+   LL    R  LA
Sbjct: 1332 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLA 1391

Query: 373  AHLGLRAPSPRDS----DAESDAGKKESDGEESRLPQP-------KREGPVGGESDSEEM 421
                +RA     +      E +A  +E  G E +  Q        ++E   G     EE 
Sbjct: 1392 LGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEA 1451

Query: 422  FEKTSGFGSGKPSEASEPCPT-------------ELLKAREDSEYLVTLKHEAQRLERTV 468
              + +          +E   T             EL  A  D E    L    ++ +R  
Sbjct: 1452 RRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKF 1511

Query: 469  ERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQG------EGDQQEPQLLGTINAKMKAF 522
            ++L+ +  +    A LR          +G E +          ++E +    +  + +A 
Sbjct: 1512 DQLLAEEKA----AVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRAL 1567

Query: 523  KKELQAFLEQVNRIGDGLSPLPHLTE-----SSSFLSTVTSVSRDSPIGNLGKELGPDLQ 577
            + EL+A L   + +G  +  L          ++   + VT +  +       K       
Sbjct: 1568 RAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTV 1627

Query: 578  SRLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLP 637
              LK Q E  L   R +  E  R + A++L    D +        Q   ++  R      
Sbjct: 1628 QALKTQHERDL-QGRDEAGEERRRQLAKQLR---DAEVERDEERKQRTLAVAAR-----K 1678

Query: 638  EQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHE 697
            +    +EEL+ Q+  A +  +E  +       +M+E       W+E+E        T  E
Sbjct: 1679 KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE------LWREVEE-----TRTSRE 1727

Query: 698  RTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQ-MEEEGEEFTEG-------- 748
              +S  +   ++ L+ L+  +     +L    +  RQ +Q  +E  +E   G        
Sbjct: 1728 EIFSQNRE-SEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAIL 1786

Query: 749  -EHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQ-TADR 806
             E  +   RLG+L  +   +    +  +DR           + ++ +   SL  + +A+R
Sbjct: 1787 EEKRQLEGRLGQLEEELEEEQSNSELLNDR-----------YRKLLLQVESLTTELSAER 1835

Query: 807  GQPHKQVVENQQLFSAFKALLEDFRAEL-REDERARLRLQQQYASDKAAWDVEWAVLKCR 865
                           +F A  E  R +L R+ +  R RL ++ A  +A   +  A L+ +
Sbjct: 1836 ---------------SFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESK 1880

Query: 866  L----EQLEEKTENKL--GELGSSAESK-----GALKKEREVHQKL---LADSHSLVMDL 911
            L    EQLE++T  ++  G+L   AE +       +++ER V  +L   L   +  V  L
Sbjct: 1881 LAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQL 1940

Query: 912  RWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQKE-----NSPRRG 963
            + Q+  +E        E   R    R+  +R+ ++     E + +E     N  RRG
Sbjct: 1941 KRQLEEAE--------EEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRG 1989



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 76/350 (21%), Positives = 139/350 (39%), Gaps = 80/350 (22%)

Query: 15   QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQD---------- 64
            +++E R   +      R  + RL+  E + L++ E         R  +QD          
Sbjct: 1718 EVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVAN 1777

Query: 65   --------LKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELER 116
                    L+  + +  RL    + +EE+++ +E  N+  R+ +++VE    +L  EL  
Sbjct: 1778 GNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVE----SLTTELSA 1833

Query: 117  LKESSLKRRSTREMYKEK------KTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREK 170
             +  S K  S R+  + +      +   +D  A  R ++  A  E        +KL + +
Sbjct: 1834 ERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALE--------SKLAQAE 1885

Query: 171  DELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLR--LKLVEEEANILGRKIVEL 228
            ++LEQE ++ + L G +               R AE +L+  +  VEEE  +  +   +L
Sbjct: 1886 EQLEQETRE-RILSGKL--------------VRRAEKRLKEVVLQVEEERRVADQLRDQL 1930

Query: 229  EVEN---RGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEA 285
            E  N   + LK ++E+   +  R   GR                    L+R L+ V E A
Sbjct: 1931 EKGNLRVKQLKRQLEEAEEEASRAQAGR------------------RRLQRELEDVTESA 1972

Query: 286  ELLRRSISEIEDHNRQ--LTHEL----SKFKFEPPREPGWLGEGASPGAG 329
            E + R ++ + +  R+  LT         F+ E         E A PG+G
Sbjct: 1973 ESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQPGSG 2022


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 222/1016 (21%), Positives = 381/1016 (37%), Gaps = 134/1016 (13%)

Query: 15   QLQELRRELDRANKNCRILQYRLRKAE-QKSLKVAETGQVDGELIR--------SLEQDL 65
            +L E+R  L RA     +LQ    KAE  ++L  AE G+V+ EL          SL+  L
Sbjct: 681  ELVEVREALSRATLQRDMLQ--AEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSL 738

Query: 66   KVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRR 125
                 ++  L  +   +    A+ E+E   L+ +  + E      + E ERL+E  L++ 
Sbjct: 739  SKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQE 798

Query: 126  STREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQEL-QKYKSLY 184
              R+  +      +     L  QL   + E   +++++A+L R+    EQEL Q  +   
Sbjct: 799  VARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQ 858

Query: 185  GDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLK-------- 236
              V++           +   A L ++L   E E   L  +   L +E   L+        
Sbjct: 859  RQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQR 918

Query: 237  --AEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEA----ELLRR 290
              A++E  R Q E EG     A    T            LR+ +   +E+A    EL+ +
Sbjct: 919  QLAQLEARREQLEAEGQALLLAKETLTGELAG-------LRQQIIATQEKASLDKELMAQ 971

Query: 291  SISEIED------HNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKS--AR 342
             + + E         ++  HE    + +  +E  W  E  +  A   + LQ E +   AR
Sbjct: 972  KLVQAEREAQASLREQRAAHEEDLQRLQREKEAAW-RELEAERAQLQSQLQREQEELLAR 1030

Query: 343  LQI--SELSGKVLKLQHE-NHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGE 399
            L+    ELS ++  LQ E +  LL  +   +    L L+  S + + +E   G + S   
Sbjct: 1031 LEAEKEELSEEIAALQQERDEGLL--LAESEKQQALSLK-ESEKTALSEKLMGTRHSLAT 1087

Query: 400  ES-RLPQPKREGPVGGESDSEEMFEKTSGFGS--GKPSEASEPCPTELLKAREDSEYLVT 456
             S  + + KR+     E D   +   TS       +  EA+     E+ + +E +  L  
Sbjct: 1088 ISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGK 1147

Query: 457  LK----HEAQRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLL 512
             +     EA+ L RT  RL+ D    L    L     L         E  EG + + Q  
Sbjct: 1148 QRDSCLREAEEL-RTQLRLLEDARDGLRRELLEAQRKL--------RESQEGREVQRQEA 1198

Query: 513  GTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNL---- 568
            G +   +    KE +A    + R  + L       ES      + +  ++  +  L    
Sbjct: 1199 GELRRSLGEGAKEREA----LRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEAR 1254

Query: 569  ---GKELG---PDLQ----SRLKEQLEWQLGPARGDERESLRLRAAREL----HRRADGD 614
               GKE G     LQ    SRL+ + E Q    +    +S   R  REL     R A G+
Sbjct: 1255 TAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGE 1314

Query: 615  TGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEETETFTNKIHKM--- 671
                    +T   L LR    L +   S+E ++ +L  A R  QE+   F  +  ++   
Sbjct: 1315 RAEKESRRET---LGLR--QRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGS 1369

Query: 672  -------EEEHLYALRWKELEMHSL---ALQNTLHERTWSDEKNLMQQELRSLKQNIFLF 721
                   E++ L   R  EL++ +    A +  L           ++ EL  ++      
Sbjct: 1370 LEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAA 1429

Query: 722  YVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGF 781
              +L  L    R+G  +         G  P    R     V G    D P   S  G   
Sbjct: 1430 EAQLGGLRSALRRGLGL---------GRAPSPAPR----PVPGSPARDAPAEGSGEGLNS 1476

Query: 782  PVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFSAFKALLEDFRAELREDERAR 841
            P       S ++    S          P    ++ + +  A +  L++ R+  RE +  R
Sbjct: 1477 P-------STLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELR 1529

Query: 842  LR---LQQQYASDKAAWDVEWA---VLKCRLEQLEEKTENKLGELGSSAESKGALKKE-- 893
             +   L +Q A  +A  D   +    L+  + + EE   +  G L S  +++ AL++E  
Sbjct: 1530 TQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRL-SGVQAELALQEESV 1588

Query: 894  -REVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFL 948
             R   ++         ++   Q   SE   ++EK+  +   +   +  +R+ KE L
Sbjct: 1589 RRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVL 1644



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 227/1052 (21%), Positives = 411/1052 (39%), Gaps = 193/1052 (18%)

Query: 1    MEEMRDSYLEE-DVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIR 59
            ++E + SY  +   YQ  + R+         +ILQY+ R +E +   +  +G+++ + +R
Sbjct: 148  LQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLR 207

Query: 60   SLE--QDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERL 117
              E  QDL+ A    +RL  E    +++ A     N  LR+Q+ +   + QAL  ++ ++
Sbjct: 208  DTEHSQDLESAL---IRLEEE----QQRSASLAQVNAMLREQLDQAGSANQALSEDIRKV 260

Query: 118  KESSLKRRSTRE-----MYKEKKTFNQDDSAD-LRCQLQFAKEEAFLMRKKMAKLGREKD 171
                 + R   E       +E+++FN   S +  R  L + +   F       K+  E+D
Sbjct: 261  TNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERD 320

Query: 172  --ELEQELQKYKSLYGDVDSPLPTG--------EAGGPPST---REAELKLRLKLVEEEA 218
              +L  EL +      +    L TG        EA          + E +LR K++ E+ 
Sbjct: 321  LLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKD 380

Query: 219  NILGRKIVELEVENRGLKAEMEDMR---GQQEREGPGRDHAPSIPTSPFGDSLESSTELR 275
              L ++ ++ +++   L A + ++     + E++   +D      T    ++LE S  L+
Sbjct: 381  --LAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKL-EALE-SLRLQ 436

Query: 276  RHLQFVEEEAELLRRSISEI--------------------EDHNRQLTHELSKFKFEPPR 315
                   E+ E L++++ ++                     D +      LS  +   P 
Sbjct: 437  EQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPP 496

Query: 316  EPGWLGEGASPGAGGG---------APLQEELKSARLQISELSGKVLKLQHENHALLSNI 366
                 G G SP  G           A +   L   +LQ+ ++ G+       +  LL  +
Sbjct: 497  RRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGR----YEASQDLLGTL 552

Query: 367  QRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTS 426
            ++              + SD+ES+    E   E+ +  + K +G +    D++   ++  
Sbjct: 553  RK--------------QLSDSESERRALE---EQLQRLRDKTDGAMQAHEDAQREVQRLR 595

Query: 427  GFG---SGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDAG 483
                  S + S  +        +A E  +    L+   + L R  +RL  + +  + D G
Sbjct: 596  SANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQD-G 654

Query: 484  LRGGAPLPGPGLQGEEEQGEGD-----------------------QQEPQLLGTINAKMK 520
             R    L     Q E+ +G+                         Q E   +     K +
Sbjct: 655  ARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE 714

Query: 521  AFKKELQAFLEQVN----RIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDL 576
            A + EL+  + ++      + D LS L  L ES +       +  +  +  L +E    L
Sbjct: 715  AGRVELELSMTKLRAEEASLQDSLSKLSALNESLA----QDKLDLNRLVAQLEEEKSA-L 769

Query: 577  QSRLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVL 636
            Q R + Q E +   AR ++     LR  +E+ R+  G  GS  +  Q   +LE + P + 
Sbjct: 770  QGR-QRQAEQEATVAREEQERLEELRLEQEVARQ--GLEGSLRVAEQAQEALEQQLPTLR 826

Query: 637  PEQSVSIEELQGQLVQAARL---HQEETETFTNKIHKMEEEHLYALRWKEL---EMHSLA 690
             E+S    +LQ QL Q +R     ++E E    +  +  E    A R KE    E   LA
Sbjct: 827  HERS----QLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLA 882

Query: 691  LQNTLHE---RTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTE 747
            +Q    E   RT S+E   ++ E  +L+ ++F      R L +   + +Q+E EG+    
Sbjct: 883  VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQ---RQLAQLEARREQLEAEGQALLL 939

Query: 748  GEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRG 807
             +  ETL+  GEL                                  G     + T ++ 
Sbjct: 940  AK--ETLT--GELA---------------------------------GLRQQIIATQEKA 962

Query: 808  QPHKQVVENQQLFSAFKALLEDFRAELREDERARLR-LQQQYASDKAAW---DVEWAVLK 863
               K+++  Q+L  A +    + +A LRE   A    LQ+     +AAW   + E A L+
Sbjct: 963  SLDKELMA-QKLVQAER----EAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQ 1017

Query: 864  CRLEQLEEKTENKL-GELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNW 922
             +L++ +E+   +L  E    +E   AL++ER+    LLA+S          +  SEK  
Sbjct: 1018 SQLQREQEELLARLEAEKEELSEEIAALQQERD-EGLLLAESEK---QQALSLKESEKTA 1073

Query: 923  NREK-VELLDRLDRDRQEWERQKKEFLWRIEQ 953
              EK +     L     E ERQK++   R EQ
Sbjct: 1074 LSEKLMGTRHSLATISLEMERQKRDAQSRQEQ 1105



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 83/369 (22%), Positives = 152/369 (41%), Gaps = 49/369 (13%)

Query: 78   ELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLK------------------- 118
            EL++ + +R +   +   L +Q+ E+E  + +  +   +L+                   
Sbjct: 1517 ELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSG 1576

Query: 119  ---ESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQ 175
               E +L+  S R   +E++    D  A L   LQ  + E    ++K++K+   + +LE 
Sbjct: 1577 VQAELALQEESVRRSERERRA-TLDQVATLERSLQATESELRASQEKISKMKANETKLEG 1635

Query: 176  ELQKYKSLYGDVDSPLPTGEAGGPPSTREAEL-KLRLKLVEEEA---------NILGRKI 225
            + ++ K +    +S   T +      + E EL + RL L + EA         + L R++
Sbjct: 1636 DKRRLKEVLDASES--RTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV 1693

Query: 226  VELEVENRGLKAEMEDMRGQ----QEREGPGRDHAPSI--PTSPFGDSLESSTELRRHLQ 279
             + EV+   L+  +E + G     +E EG  RD    +    +    SL S+ +   HLQ
Sbjct: 1694 ADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQ 1753

Query: 280  FVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELK 339
                  E  R+ + E  D  RQ   E  K       +   LGE      G  A L+ +  
Sbjct: 1754 KALTACEHDRQVLQERLDAARQALSEARK-------QSSSLGEQVQTLRGEVADLELQRV 1806

Query: 340  SARLQISELSGKVLKLQHENHALLSNIQRC-DLAAHLGLRAPSPRDSDAESDAGKKESDG 398
             A  Q+ +L   + + Q    A L+ +Q+  D    L  R  S + + A+ +A K+E + 
Sbjct: 1807 EAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVER 1866

Query: 399  EESRLPQPK 407
               RL + +
Sbjct: 1867 SALRLEKDR 1875



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 199/957 (20%), Positives = 343/957 (35%), Gaps = 193/957 (20%)

Query: 75   LHHELKTVEEKRAKAEDENE---TLRQQMIEVEISKQALQNELERLKESS---------- 121
            LH     V++ R + E   +   TLR+Q+ + E  ++AL+ +L+RL++ +          
Sbjct: 528  LHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDA 587

Query: 122  ----LKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQEL 177
                 + RS  E+   +K       ++L   LQ A+++A  +R++  KL   ++EL ++ 
Sbjct: 588  QREVQRLRSANELLSREK-------SNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQR 640

Query: 178  QKYKSLYGDVDSPLPTGEAGGPPSTREAELKLR-LKLVEEEANILGRKIVELEVENRGLK 236
             + +    D           G    RE E   R L+ +E + ++L +++VE+  E     
Sbjct: 641  DRLEEEQED-------AVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVR-EALSRA 692

Query: 237  AEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIE 296
                DM   ++ E      A ++  +  G       EL   +  +  E   L+ S+S++ 
Sbjct: 693  TLQRDMLQAEKAE-----VAEALTKAEAG-----RVELELSMTKLRAEEASLQDSLSKLS 742

Query: 297  DHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQ 356
              N  L  +    K +  R    L E  S   G     ++E   AR +   L  + L+L+
Sbjct: 743  ALNESLAQD----KLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERL--EELRLE 796

Query: 357  HENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGES 416
             E              A  GL        +      ++  +  E +LP  + E      S
Sbjct: 797  QE-------------VARQGL--------EGSLRVAEQAQEALEQQLPTLRHE-----RS 830

Query: 417  DSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTD 476
              +E   + S   SG+  E                  L   + EAQR    +ER   + +
Sbjct: 831  QLQEQLAQLSRQLSGREQE------------------LEQARREAQRQVEALERAAREKE 872

Query: 477  SFLHD-AGL--------RGGAPL--PGPGLQGEEEQGEGDQQEPQ-LLGTINAKMKAFKK 524
            +   + AGL        R G  L      L+ E+E  EG   E Q  L  + A+ +  + 
Sbjct: 873  ALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEA 932

Query: 525  ELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQL 584
            E QA L     +   L+ L         ++T    S D       KEL      + + + 
Sbjct: 933  EGQALLLAKETLTGELAGL-----RQQIIATQEKASLD-------KELMAQKLVQAEREA 980

Query: 585  EWQLGPARGDERESL-RLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSI 643
            +  L   R    E L RL+  +E   R            Q    L+     +L       
Sbjct: 981  QASLREQRAAHEEDLQRLQREKEAAWRE-----LEAERAQLQSQLQREQEELLARLEAEK 1035

Query: 644  EELQGQLVQAARLHQEETETFTNKIHKMEEEHLYALRWKELE-----------MHSLALQ 692
            EEL  ++   A L QE  E     +   E E   AL  KE E            HSLA  
Sbjct: 1036 EELSEEI---AALQQERDE----GLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATI 1088

Query: 693  NTLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPE 752
            +   ER   D ++  +Q+  ++             L    R  +   EE        H +
Sbjct: 1089 SLEMERQKRDAQSRQEQDRSTVNA-----------LTSELRDLRAQREE----AAAAHAQ 1133

Query: 753  TLSRLGELGVQGGHQADGPDHDS-----------DRGCGFPVGEHSPHSRVQIGDHSLRL 801
             + RL E     G Q D    ++           D   G          +++       +
Sbjct: 1134 EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREV 1193

Query: 802  QTADRGQPHKQVVENQQLFSAFKALLEDFRAELR--EDERARLRLQQQYASDKAAWDVEW 859
            Q  + G+  + + E  +   A +   E+ R+ ++  E ER  L+L  +    K A     
Sbjct: 1194 QRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLA----- 1248

Query: 860  AVLKCRLEQLEEKTENKLGEL--GSSAESKGALKKEREV----HQKLLADSHSL-----V 908
                  LE+       + GEL  G     +  L+  RE+     Q  + DS +      +
Sbjct: 1249 -----LLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGREL 1303

Query: 909  MDLRWQI---HHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQKENSPRR 962
             +L+ ++     +EK   RE + L  RL +     E  ++E      +LQ++    R
Sbjct: 1304 AELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFR 1360



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 167/810 (20%), Positives = 286/810 (35%), Gaps = 130/810 (16%)

Query: 56   ELIRSLEQDLKVAKDVSVRLHHELKTVEEKR--------------AKAEDENETLRQQMI 101
            +L+ +L + L  ++     L  +L+ + +K                +    NE L ++  
Sbjct: 547  DLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKS 606

Query: 102  EVEISKQALQNELERLKESSLK-------RRSTREMYKEKKTFNQDDSADLRCQLQFAKE 154
             +  S Q  Q + E L++   K        R  R+  +E++     D A +R +L+ +  
Sbjct: 607  NLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHR 666

Query: 155  EAFLMRKKMAKLGREKDELEQELQK-------YKSLYGDVDSPLPTGEAGGPPSTREAEL 207
            +   +  K + L +E  E+ + L +        ++   +V   L   EAG        EL
Sbjct: 667  QLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAG------RVEL 720

Query: 208  KLRL-KLVEEEANI--------------------LGRKIVELEVENRGL-----KAEMED 241
            +L + KL  EEA++                    L R + +LE E   L     +AE E 
Sbjct: 721  ELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEA 780

Query: 242  MRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQ-FVEEEAELLRRSISEIEDHNR 300
               ++E+E   R     +        LE S  +    Q  +E++   LR   S++++   
Sbjct: 781  TVAREEQE---RLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLA 837

Query: 301  QLTHELS------------------------KFKFEPPREPGWLGEGASPGAGGGAPLQE 336
            QL+ +LS                        + K    +E   L          G  L E
Sbjct: 838  QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSE 897

Query: 337  ELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSD---------A 387
            E    RL+   L G + ++Q +   L +  ++ +      L A      +         A
Sbjct: 898  EATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIA 957

Query: 388  ESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSE----ASEPCPTE 443
              +    + +    +L Q +RE             E        K +      +E    +
Sbjct: 958  TQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQ 1017

Query: 444  LLKAREDSEYLVTLKHEAQRLERTVERLITDTDS--FLHDAGLRGGAPLPGPGLQGEEEQ 501
                RE  E L  L+ E + L   +  L  + D    L ++  +    L         E+
Sbjct: 1018 SQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEK 1077

Query: 502  GEGDQQEPQLLGTINAKMKAFKKELQAFLEQ----VNRIGDGLSPLPHLTESSSFLSTVT 557
              G +     L TI+ +M+  K++ Q+  EQ    VN +   L  L    E ++      
Sbjct: 1078 LMGTRHS---LATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQE 1134

Query: 558  SVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLR---LRAARELHRRADGD 614
                     +LGK+   D   R  E+L  QL     D R+ LR   L A R+L    +G 
Sbjct: 1135 VRRLQEQARDLGKQ--RDSCLREAEELRTQLRLLE-DARDGLRRELLEAQRKLRESQEGR 1191

Query: 615  TGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEE 674
                   G+   SL   G         S EEL+  + +A      E+E  + K+   ++E
Sbjct: 1192 EVQRQEAGELRRSLG-EGAKEREALRRSNEELRSAVKKA------ESERISLKLANEDKE 1244

Query: 675  HLYALRWKELEMHSLALQNTLHE-RTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWR 733
               AL    LE    A+     E RT   E    + E R   Q +      L    ++ R
Sbjct: 1245 QKLAL----LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLD--SENTR 1298

Query: 734  QGKQMEEEGEEFTEGEHPETLSRLGELGVQ 763
             G+++ E       GE  E  SR   LG++
Sbjct: 1299 LGRELAELQGRLALGERAEKESRRETLGLR 1328



 Score = 36.2 bits (82), Expect = 0.26
 Identities = 41/223 (18%), Positives = 98/223 (43%), Gaps = 24/223 (10%)

Query: 58   IRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERL 117
            + + E D +V ++        L    ++ +   ++ +TLR ++ ++E+ +   + +L++L
Sbjct: 1756 LTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQL 1815

Query: 118  KESSLKRR-------STREMYKEKKTFNQDDSADLR---CQLQFAKEEA----------- 156
            +E   +R+       +T +  ++++   Q+    L+    QL+  K E            
Sbjct: 1816 REVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDR 1875

Query: 157  FLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEE 216
              +R+ + K+ REK    ++  +  +  G +D  L   E     + R+ +      +V E
Sbjct: 1876 VALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLE 1935

Query: 217  EANILGRKIVELEVENRGLKAEMEDMR---GQQEREGPGRDHA 256
            +++   +  V+ + +   L+ E+E +R    Q ER    R+ A
Sbjct: 1936 QSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERA 1978



 Score = 33.1 bits (74), Expect = 2.2
 Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 19/160 (11%)

Query: 801  LQTADRGQPHKQVVENQQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEWA 860
            L T  + Q  ++++  Q+   + +  L    AE RE ER+ LRL++    D+ A      
Sbjct: 1830 LNTVQKLQDERRLL--QERLGSLQRALAQLEAEKREVERSALRLEK----DRVA------ 1877

Query: 861  VLKCRLEQLE-EKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSE 919
             L+  L+++E EK  +    +  SAE KG L +     +  LA++   +  L  Q+   E
Sbjct: 1878 -LRRTLDKVEREKLRSHEDTVRLSAE-KGRLDRTLTGAELELAEAQRQIQQLEAQVVVLE 1935

Query: 920  KNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQKENS 959
            ++ +  ++E    +D  +Q+ E Q++    R  Q Q E +
Sbjct: 1936 QSHSPAQLE----VDAQQQQLELQQEVERLRSAQAQTERT 1971


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 201/996 (20%), Positives = 383/996 (38%), Gaps = 108/996 (10%)

Query: 15   QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVR 74
            ++Q    EL +  +  +  +  L++ EQK  ++ E   +  E +++  +    A+++ VR
Sbjct: 853  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912

Query: 75   LHHELKTVEE--KRAKAEDENETLRQQMIEVEISKQA-----LQNELERLKESSLKRRST 127
            L  + + +EE     +A  E E  R Q ++ E  K A     L+ +LE  + +  K +  
Sbjct: 913  LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 972

Query: 128  REMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLG---REKDELEQELQKYKSLY 184
            +   + K    +D+   +  Q     +E  L+ ++++ L     E++E  + L K K+ +
Sbjct: 973  KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032

Query: 185  GDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRG 244
              + S L         S +E E KL+ KL E +A+    +I +L+ +   LK ++     
Sbjct: 1033 ESMISELEVRLKKEEKSRQELE-KLKRKL-EGDASDFHEQIADLQAQIAELKMQL----A 1086

Query: 245  QQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTH 304
            ++E E            +   ++L+   EL  H+  ++E+ +  R + ++ E   R L  
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146

Query: 305  ELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLS 364
            EL   K E       L +     A      Q+EL++ R Q   +  K L  +  +H    
Sbjct: 1147 ELEALKTE-------LEDTLDSTA-----TQQELRAKREQEVTVLKKALDEETRSHEAQV 1194

Query: 365  NIQRC-------DLAAHLGLRAPSPRDSDAESDAGKKES---DGEESRLPQPKREGPVGG 414
               R        +L   L     +  + D      +KE+    GE   L Q K+E     
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1254

Query: 415  ESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQ------------ 462
            +    ++ E  S    G+ + A      ++ K + + E +  + +EA+            
Sbjct: 1255 KKLEAQVQELQSKCSDGERARAE--LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312

Query: 463  ---RLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGE-EEQGEGDQQEPQLLGTINAK 518
               +L+ T E L  +T   L+ +            LQ + +E+ E  Q   + + T+N +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372

Query: 519  MKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQS 578
            +   KK+LQ F   V  + +G            F   + ++++        K    D   
Sbjct: 1373 LSDSKKKLQDFASTVEALEEG---------KKRFQKEIENLTQQYE----EKAAAYDKLE 1419

Query: 579  RLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLEL-RGPPVLP 637
            + K +L+ +L     D     +L +  E  +R      +      + ++ E  R      
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479

Query: 638  EQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEHLYALR------WKELEMHSLAL 691
            E+      L   L +A  L  +E    TNK+ K E E L + +        ELE    AL
Sbjct: 1480 EKETKALSLARALEEA--LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1537

Query: 692  QNTLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHP 751
            +  + E     E+  ++ EL++ +       V ++ L   + +  Q  +E  E    +  
Sbjct: 1538 ETQMEEMKTQLEE--LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595

Query: 752  ETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPH- 810
              L           ++ +  D    R                + D  L+  +A +G+   
Sbjct: 1596 RQLHE---------YETELEDERKQRAL---AAAAKKKLEGDLKDLELQADSAIKGREEA 1643

Query: 811  -KQVVENQQLFSAFKALLEDFRA---ELREDERARLRLQQQYASDKAAWDVEWAVLKCRL 866
             KQ+ + Q     F+  LED RA   E+    +   +  +   +D      + A  +   
Sbjct: 1644 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703

Query: 867  EQLEEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREK 926
            +Q + + E    EL SS   + AL+ E+   ++L A    L  +L       E+  N E 
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEK---RRLEARIAQLEEEL------EEEQGNMEA 1754

Query: 927  VELLDRLDRDRQEWERQKKEFLWRIEQLQKENSPRR 962
            +   DR+ +  Q+ E+   E        QK  S R+
Sbjct: 1755 MS--DRVRKATQQAEQLSNELATERSTAQKNESARQ 1788



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 88/398 (22%), Positives = 163/398 (40%), Gaps = 43/398 (10%)

Query: 6    DSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDL 65
            ++ LEE+  + Q+L+ E  +  +    L+ +L + E    K+          I+ LE ++
Sbjct: 928  EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 987

Query: 66   KVAKDVSVRLHHELKTVEEKRAKAED---ENETLRQQMIEVEISKQALQNELE-RLKESS 121
             V  D + +L  E K +EE+ +       E E   + + +++   +++ +ELE RLK+  
Sbjct: 988  LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK-- 1045

Query: 122  LKRRSTREMYKEKKTFNQDDS------ADLRCQL-----QFAKEEAFLMRKKMAKLGREK 170
             + +S +E+ K K+    D S      ADL+ Q+     Q AK+E  L     A L R  
Sbjct: 1046 -EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ----AALARLD 1100

Query: 171  DELEQE---LQKYKSLYG-------DVDSPLPTG--------EAGGPPSTREAELKLRLK 212
            DE+ Q+   L+K + L G       D+DS             + G      + EL+  L 
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160

Query: 213  LVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESST 272
                +  +  ++  E+ V  + L  E      Q +        A    T        +  
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220

Query: 273  ELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGA 332
             L ++ Q +E+E   L   +  +    +++ H+  K + +         +G    A    
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280

Query: 333  P---LQEELKSARLQISELSGKVLKLQHENHALLSNIQ 367
                LQ E++S    ++E  GK +KL  +  +L S +Q
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 181/927 (19%), Positives = 367/927 (39%), Gaps = 151/927 (16%)

Query: 56   ELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQM-IEVEISKQALQNEL 114
            E +++ E +L+  K+   +  +ELK +E+K ++  +E   L++Q+  E E+  +A   E 
Sbjct: 852  EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA---EE 908

Query: 115  ERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELE 174
             R++ ++ K+     +++ +    +++    + Q +         RKKMA   ++  +LE
Sbjct: 909  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE---------RKKMA---QQMLDLE 956

Query: 175  QELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRG 234
            ++L++ ++    +     T EA             ++K +E+E  ++  +  +L  E + 
Sbjct: 957  EQLEEEEAARQKLQLEKVTAEA-------------KIKKLEDEILVMDDQNNKLSKERKL 1003

Query: 235  LKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELR-RHLQFVEEEAELLRRSIS 293
            L+  + D+      E                +  ++ T+L+ +H   + E    L++   
Sbjct: 1004 LEERISDLTTNLAEE---------------EEKAKNLTKLKNKHESMISELEVRLKK--- 1045

Query: 294  EIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVL 353
              E+ +RQ   EL K K +                G  +   E++   + QI+EL  ++ 
Sbjct: 1046 --EEKSRQ---ELEKLKRKL--------------EGDASDFHEQIADLQAQIAELKMQLA 1086

Query: 354  KLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEE-SRLPQPKREGPV 412
            K + E  A L+ +   D  A         R+ +      +++ D E  +R    K++  +
Sbjct: 1087 KKEEELQAALARLD--DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144

Query: 413  GGESDS--EEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLE----- 465
            G E ++   E+ +      + +   A       +LK   D E   T  HEAQ  E     
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE---TRSHEAQVQEMRQKH 1201

Query: 466  -RTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKK 524
             + VE L    + F      R  A L     Q  E++      E ++LG    +++  KK
Sbjct: 1202 AQAVEELTEQLEQF-----KRAKANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255

Query: 525  ELQAFLEQV-NRIGDGLSPLPHLTES----SSFLSTVTSVSRDS---------PIGNLGK 570
            +L+A ++++ ++  DG      L +      + + +VT +  ++          + +L  
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315

Query: 571  ELGPDLQSRLKEQLEWQLGPAR-----GDERESLRLRAARELHRRADGDTGSHGLGGQTC 625
            +L  D Q  L+E+   +L  +       +ER SL+ +   E+  + + +     L  Q  
Sbjct: 1316 QL-QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374

Query: 626  FSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEHLYALRWKELE 685
             S +      L + + ++E L+    +  +  Q+E E  T +  +       A  + +LE
Sbjct: 1375 DSKK-----KLQDFASTVEALE----EGKKRFQKEIENLTQQYEEK------AAAYDKLE 1419

Query: 686  MHSLALQNTLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWR--QGKQMEEEGE 743
                 LQ  L      D+  +     R L  N+     K   LL   +    K  +E   
Sbjct: 1420 KTKNRLQQEL------DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473

Query: 744  EFTEGEHPET----LSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSL 799
               E    ET    L+R  E  ++   + +  +            E    S+  +G +  
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM-----EDLVSSKDDVGKNVH 1528

Query: 800  RLQTADRGQPHKQVVENQQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEW 859
             L+ +      K+ +E Q      K  LE+   EL+  E A+LRL+    + K  ++ + 
Sbjct: 1529 ELEKS------KRALETQ--MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD- 1579

Query: 860  AVLKCRLEQLEEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSE 919
              L+ R EQ EEK      +L          +K+R +           + DL  Q   + 
Sbjct: 1580 --LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637

Query: 920  KNWNREKVELLDRLDRDRQEWERQKKE 946
            K    E ++ L +L    ++++R+ ++
Sbjct: 1638 KG-REEAIKQLRKLQAQMKDFQRELED 1663



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 57/214 (26%), Positives = 95/214 (44%), Gaps = 27/214 (12%)

Query: 9    LEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAE---TGQVDGELIRSLEQDL 65
            LE  + QL+E   EL+    N   +  R+RKA Q++ +++    T +   +   S  Q L
Sbjct: 1734 LEARIAQLEE---ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1790

Query: 66   -KVAKDVSVRLHHELKTVEEK--------RAKAEDENETLRQQMIEVEISKQALQNELER 116
             +  K++  +LH     V+ K         AK     E + Q+  E + + ++L+ + ++
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850

Query: 117  LKESSLK---RRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDEL 173
            LKE  L+    R   E YKE+          L+ QL+ A+EE+  +     KL RE DE 
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910

Query: 174  ---------EQELQKYKSLYGDVDSPLPTGEAGG 198
                     E    K K   G+  S +P+  +GG
Sbjct: 1911 TESNEAMGREVNALKSKLRRGNETSFVPSRRSGG 1944



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 140/663 (21%), Positives = 259/663 (39%), Gaps = 92/663 (13%)

Query: 9    LEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVA 68
            L   +   QEL +E  R   N   +  +LR+ E++   + +    + E  ++LE+ +   
Sbjct: 1313 LSSQLQDTQELLQEETRQKLN---VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369

Query: 69   K----DVSVRLHHELKTVE---EKRAKAEDENETLRQQMIE-------VEISKQALQNEL 114
                 D   +L     TVE   E + + + E E L QQ  E       +E +K  LQ EL
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429

Query: 115  ERLK-ESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDEL 173
            + L  +   +R+    + K+++ F+Q              EE  +  K   +  R + E 
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQ-----------LLAEEKNISSKYADERDRAEAEA 1478

Query: 174  EQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENR 233
             ++  K  SL   ++  L   EA          LK  ++ +    + +G+ + ELE   R
Sbjct: 1479 REKETKALSLARALEEAL---EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535

Query: 234  GLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEE------EAEL 287
             L+ +ME+M+ Q E                  D L+++ + +  L+   +      E +L
Sbjct: 1536 ALETQMEEMKTQLEE---------------LEDELQATEDAKLRLEVNMQALKGQFERDL 1580

Query: 288  LRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQI-S 346
              R   + E+  RQL  +L +++ E   E     +  +  A     L+ +LK   LQ  S
Sbjct: 1581 QARD-EQNEEKRRQLQRQLHEYETELEDE----RKQRALAAAAKKKLEGDLKDLELQADS 1635

Query: 347  ELSGK--VLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLP 404
             + G+   +K   +  A + + QR      L     S  +  A +   +K++   E+ L 
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQR-----ELEDARASRDEIFATAKENEKKAKSLEADLM 1690

Query: 405  QPKREGPVG------GESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLK 458
            Q + +           + + EE+ E+ +   SG+ +   E    E   A+ + E    L+
Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE----LE 1746

Query: 459  HEAQRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQE-----PQLLG 513
             E   +E   +R+   T      +             +   +Q E   +E      ++ G
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806

Query: 514  TINAKMKAFKKELQAFLEQV-----NRIGDGLSPLPHLTESSSFLSTV-TSVSRDSPIGN 567
             + +K K+    L+A + Q+         +  +    L +    L  +   V  +  +  
Sbjct: 1807 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE 1866

Query: 568  LGKELGPDLQSRLKEQLEWQLGPARGDERESLRLRA-ARELHRRADGDTGSHGLGGQTCF 626
              KE      +R+K QL+ QL  A   E ES R+ A  R+L R  D  T S+   G+   
Sbjct: 1867 QYKEQAEKGNARVK-QLKRQLEEA---EEESQRINANRRKLQRELDEATESNEAMGREVN 1922

Query: 627  SLE 629
            +L+
Sbjct: 1923 ALK 1925



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 63/277 (22%), Positives = 116/277 (41%), Gaps = 58/277 (20%)

Query: 3    EMRDSYLEEDVYQLQELRRELDRANKNCRI------------------LQYRLRKAEQKS 44
            E +   LE D+ QLQE     +RA K   +                  LQ   R+ E + 
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1738

Query: 45   LKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTV-------EEKRAKAEDENETLR 97
             ++ E  + +   + ++   ++ A   + +L +EL T        E  R + E +N+ LR
Sbjct: 1739 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1798

Query: 98   QQMIEVEISKQ--------ALQNELERLKESSLKRRSTREMYKEKKTFNQDDS------- 142
             ++ E+E + +        AL+ ++ +L+E     +  RE     K+  Q D        
Sbjct: 1799 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ--VEQEAREKQAATKSLKQKDKKLKEILL 1856

Query: 143  --ADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKY----KSLYGDVDSPLPTGEA 196
               D R   +  KE+A     ++ +L R+ +E E+E Q+     + L  ++D    + EA
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1916

Query: 197  GGPPSTREAE-LKLRLKLVEEEANIL-----GRKIVE 227
             G    RE   LK +L+   E + +      GR+++E
Sbjct: 1917 MG----REVNALKSKLRRGNETSFVPSRRSGGRRVIE 1949


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 201/996 (20%), Positives = 383/996 (38%), Gaps = 108/996 (10%)

Query: 15   QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVR 74
            ++Q    EL +  +  +  +  L++ EQK  ++ E   +  E +++  +    A+++ VR
Sbjct: 860  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919

Query: 75   LHHELKTVEE--KRAKAEDENETLRQQMIEVEISKQA-----LQNELERLKESSLKRRST 127
            L  + + +EE     +A  E E  R Q ++ E  K A     L+ +LE  + +  K +  
Sbjct: 920  LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 979

Query: 128  REMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLG---REKDELEQELQKYKSLY 184
            +   + K    +D+   +  Q     +E  L+ ++++ L     E++E  + L K K+ +
Sbjct: 980  KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039

Query: 185  GDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRG 244
              + S L         S +E E KL+ KL E +A+    +I +L+ +   LK ++     
Sbjct: 1040 ESMISELEVRLKKEEKSRQELE-KLKRKL-EGDASDFHEQIADLQAQIAELKMQL----A 1093

Query: 245  QQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTH 304
            ++E E            +   ++L+   EL  H+  ++E+ +  R + ++ E   R L  
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153

Query: 305  ELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLS 364
            EL   K E       L +     A      Q+EL++ R Q   +  K L  +  +H    
Sbjct: 1154 ELEALKTE-------LEDTLDSTA-----TQQELRAKREQEVTVLKKALDEETRSHEAQV 1201

Query: 365  NIQRC-------DLAAHLGLRAPSPRDSDAESDAGKKES---DGEESRLPQPKREGPVGG 414
               R        +L   L     +  + D      +KE+    GE   L Q K+E     
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261

Query: 415  ESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQ------------ 462
            +    ++ E  S    G+ + A      ++ K + + E +  + +EA+            
Sbjct: 1262 KKLEAQVQELQSKCSDGERARAE--LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319

Query: 463  ---RLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGE-EEQGEGDQQEPQLLGTINAK 518
               +L+ T E L  +T   L+ +            LQ + +E+ E  Q   + + T+N +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379

Query: 519  MKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQS 578
            +   KK+LQ F   V  + +G            F   + ++++        K    D   
Sbjct: 1380 LSDSKKKLQDFASTVEALEEG---------KKRFQKEIENLTQQYE----EKAAAYDKLE 1426

Query: 579  RLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLEL-RGPPVLP 637
            + K +L+ +L     D     +L +  E  +R      +      + ++ E  R      
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486

Query: 638  EQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEHLYALR------WKELEMHSLAL 691
            E+      L   L +A  L  +E    TNK+ K E E L + +        ELE    AL
Sbjct: 1487 EKETKALSLARALEEA--LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1544

Query: 692  QNTLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHP 751
            +  + E     E+  ++ EL++ +       V ++ L   + +  Q  +E  E    +  
Sbjct: 1545 ETQMEEMKTQLEE--LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602

Query: 752  ETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPH- 810
              L           ++ +  D    R                + D  L+  +A +G+   
Sbjct: 1603 RQLHE---------YETELEDERKQRAL---AAAAKKKLEGDLKDLELQADSAIKGREEA 1650

Query: 811  -KQVVENQQLFSAFKALLEDFRA---ELREDERARLRLQQQYASDKAAWDVEWAVLKCRL 866
             KQ+ + Q     F+  LED RA   E+    +   +  +   +D      + A  +   
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710

Query: 867  EQLEEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREK 926
            +Q + + E    EL SS   + AL+ E+   ++L A    L  +L       E+  N E 
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEK---RRLEARIAQLEEEL------EEEQGNMEA 1761

Query: 927  VELLDRLDRDRQEWERQKKEFLWRIEQLQKENSPRR 962
            +   DR+ +  Q+ E+   E        QK  S R+
Sbjct: 1762 MS--DRVRKATQQAEQLSNELATERSTAQKNESARQ 1795



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 88/398 (22%), Positives = 163/398 (40%), Gaps = 43/398 (10%)

Query: 6    DSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDL 65
            ++ LEE+  + Q+L+ E  +  +    L+ +L + E    K+          I+ LE ++
Sbjct: 935  EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 994

Query: 66   KVAKDVSVRLHHELKTVEEKRAKAED---ENETLRQQMIEVEISKQALQNELE-RLKESS 121
             V  D + +L  E K +EE+ +       E E   + + +++   +++ +ELE RLK+  
Sbjct: 995  LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK-- 1052

Query: 122  LKRRSTREMYKEKKTFNQDDS------ADLRCQL-----QFAKEEAFLMRKKMAKLGREK 170
             + +S +E+ K K+    D S      ADL+ Q+     Q AK+E  L     A L R  
Sbjct: 1053 -EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ----AALARLD 1107

Query: 171  DELEQE---LQKYKSLYG-------DVDSPLPTG--------EAGGPPSTREAELKLRLK 212
            DE+ Q+   L+K + L G       D+DS             + G      + EL+  L 
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167

Query: 213  LVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESST 272
                +  +  ++  E+ V  + L  E      Q +        A    T        +  
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227

Query: 273  ELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGA 332
             L ++ Q +E+E   L   +  +    +++ H+  K + +         +G    A    
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287

Query: 333  P---LQEELKSARLQISELSGKVLKLQHENHALLSNIQ 367
                LQ E++S    ++E  GK +KL  +  +L S +Q
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 181/927 (19%), Positives = 367/927 (39%), Gaps = 151/927 (16%)

Query: 56   ELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQM-IEVEISKQALQNEL 114
            E +++ E +L+  K+   +  +ELK +E+K ++  +E   L++Q+  E E+  +A   E 
Sbjct: 859  EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA---EE 915

Query: 115  ERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELE 174
             R++ ++ K+     +++ +    +++    + Q +         RKKMA   ++  +LE
Sbjct: 916  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE---------RKKMA---QQMLDLE 963

Query: 175  QELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRG 234
            ++L++ ++    +     T EA             ++K +E+E  ++  +  +L  E + 
Sbjct: 964  EQLEEEEAARQKLQLEKVTAEA-------------KIKKLEDEILVMDDQNNKLSKERKL 1010

Query: 235  LKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELR-RHLQFVEEEAELLRRSIS 293
            L+  + D+      E                +  ++ T+L+ +H   + E    L++   
Sbjct: 1011 LEERISDLTTNLAEE---------------EEKAKNLTKLKNKHESMISELEVRLKK--- 1052

Query: 294  EIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVL 353
              E+ +RQ   EL K K +                G  +   E++   + QI+EL  ++ 
Sbjct: 1053 --EEKSRQ---ELEKLKRKL--------------EGDASDFHEQIADLQAQIAELKMQLA 1093

Query: 354  KLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEE-SRLPQPKREGPV 412
            K + E  A L+ +   D  A         R+ +      +++ D E  +R    K++  +
Sbjct: 1094 KKEEELQAALARLD--DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151

Query: 413  GGESDS--EEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLE----- 465
            G E ++   E+ +      + +   A       +LK   D E   T  HEAQ  E     
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE---TRSHEAQVQEMRQKH 1208

Query: 466  -RTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKK 524
             + VE L    + F      R  A L     Q  E++      E ++LG    +++  KK
Sbjct: 1209 AQAVEELTEQLEQF-----KRAKANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262

Query: 525  ELQAFLEQV-NRIGDGLSPLPHLTES----SSFLSTVTSVSRDS---------PIGNLGK 570
            +L+A ++++ ++  DG      L +      + + +VT +  ++          + +L  
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322

Query: 571  ELGPDLQSRLKEQLEWQLGPAR-----GDERESLRLRAARELHRRADGDTGSHGLGGQTC 625
            +L  D Q  L+E+   +L  +       +ER SL+ +   E+  + + +     L  Q  
Sbjct: 1323 QL-QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381

Query: 626  FSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEHLYALRWKELE 685
             S +      L + + ++E L+    +  +  Q+E E  T +  +       A  + +LE
Sbjct: 1382 DSKK-----KLQDFASTVEALE----EGKKRFQKEIENLTQQYEEK------AAAYDKLE 1426

Query: 686  MHSLALQNTLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWR--QGKQMEEEGE 743
                 LQ  L      D+  +     R L  N+     K   LL   +    K  +E   
Sbjct: 1427 KTKNRLQQEL------DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480

Query: 744  EFTEGEHPET----LSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSL 799
               E    ET    L+R  E  ++   + +  +            E    S+  +G +  
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM-----EDLVSSKDDVGKNVH 1535

Query: 800  RLQTADRGQPHKQVVENQQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEW 859
             L+ +      K+ +E Q      K  LE+   EL+  E A+LRL+    + K  ++ + 
Sbjct: 1536 ELEKS------KRALETQ--MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD- 1586

Query: 860  AVLKCRLEQLEEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSE 919
              L+ R EQ EEK      +L          +K+R +           + DL  Q   + 
Sbjct: 1587 --LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644

Query: 920  KNWNREKVELLDRLDRDRQEWERQKKE 946
            K    E ++ L +L    ++++R+ ++
Sbjct: 1645 KG-REEAIKQLRKLQAQMKDFQRELED 1670



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 57/214 (26%), Positives = 95/214 (44%), Gaps = 27/214 (12%)

Query: 9    LEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAE---TGQVDGELIRSLEQDL 65
            LE  + QL+E   EL+    N   +  R+RKA Q++ +++    T +   +   S  Q L
Sbjct: 1741 LEARIAQLEE---ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1797

Query: 66   -KVAKDVSVRLHHELKTVEEK--------RAKAEDENETLRQQMIEVEISKQALQNELER 116
             +  K++  +LH     V+ K         AK     E + Q+  E + + ++L+ + ++
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857

Query: 117  LKESSLK---RRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDEL 173
            LKE  L+    R   E YKE+          L+ QL+ A+EE+  +     KL RE DE 
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917

Query: 174  ---------EQELQKYKSLYGDVDSPLPTGEAGG 198
                     E    K K   G+  S +P+  +GG
Sbjct: 1918 TESNEAMGREVNALKSKLRRGNETSFVPSRRSGG 1951



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 140/663 (21%), Positives = 259/663 (39%), Gaps = 92/663 (13%)

Query: 9    LEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVA 68
            L   +   QEL +E  R   N   +  +LR+ E++   + +    + E  ++LE+ +   
Sbjct: 1320 LSSQLQDTQELLQEETRQKLN---VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376

Query: 69   K----DVSVRLHHELKTVE---EKRAKAEDENETLRQQMIE-------VEISKQALQNEL 114
                 D   +L     TVE   E + + + E E L QQ  E       +E +K  LQ EL
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436

Query: 115  ERLK-ESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDEL 173
            + L  +   +R+    + K+++ F+Q              EE  +  K   +  R + E 
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQ-----------LLAEEKNISSKYADERDRAEAEA 1485

Query: 174  EQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENR 233
             ++  K  SL   ++  L   EA          LK  ++ +    + +G+ + ELE   R
Sbjct: 1486 REKETKALSLARALEEAL---EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542

Query: 234  GLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEE------EAEL 287
             L+ +ME+M+ Q E                  D L+++ + +  L+   +      E +L
Sbjct: 1543 ALETQMEEMKTQLEE---------------LEDELQATEDAKLRLEVNMQALKGQFERDL 1587

Query: 288  LRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQI-S 346
              R   + E+  RQL  +L +++ E   E     +  +  A     L+ +LK   LQ  S
Sbjct: 1588 QARD-EQNEEKRRQLQRQLHEYETELEDE----RKQRALAAAAKKKLEGDLKDLELQADS 1642

Query: 347  ELSGK--VLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLP 404
             + G+   +K   +  A + + QR      L     S  +  A +   +K++   E+ L 
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQR-----ELEDARASRDEIFATAKENEKKAKSLEADLM 1697

Query: 405  QPKREGPVG------GESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLK 458
            Q + +           + + EE+ E+ +   SG+ +   E    E   A+ + E    L+
Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE----LE 1753

Query: 459  HEAQRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQE-----PQLLG 513
             E   +E   +R+   T      +             +   +Q E   +E      ++ G
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813

Query: 514  TINAKMKAFKKELQAFLEQV-----NRIGDGLSPLPHLTESSSFLSTV-TSVSRDSPIGN 567
             + +K K+    L+A + Q+         +  +    L +    L  +   V  +  +  
Sbjct: 1814 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE 1873

Query: 568  LGKELGPDLQSRLKEQLEWQLGPARGDERESLRLRA-ARELHRRADGDTGSHGLGGQTCF 626
              KE      +R+K QL+ QL  A   E ES R+ A  R+L R  D  T S+   G+   
Sbjct: 1874 QYKEQAEKGNARVK-QLKRQLEEA---EEESQRINANRRKLQRELDEATESNEAMGREVN 1929

Query: 627  SLE 629
            +L+
Sbjct: 1930 ALK 1932



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 63/277 (22%), Positives = 116/277 (41%), Gaps = 58/277 (20%)

Query: 3    EMRDSYLEEDVYQLQELRRELDRANKNCRI------------------LQYRLRKAEQKS 44
            E +   LE D+ QLQE     +RA K   +                  LQ   R+ E + 
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1745

Query: 45   LKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTV-------EEKRAKAEDENETLR 97
             ++ E  + +   + ++   ++ A   + +L +EL T        E  R + E +N+ LR
Sbjct: 1746 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1805

Query: 98   QQMIEVEISKQ--------ALQNELERLKESSLKRRSTREMYKEKKTFNQDDS------- 142
             ++ E+E + +        AL+ ++ +L+E     +  RE     K+  Q D        
Sbjct: 1806 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ--VEQEAREKQAATKSLKQKDKKLKEILL 1863

Query: 143  --ADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKY----KSLYGDVDSPLPTGEA 196
               D R   +  KE+A     ++ +L R+ +E E+E Q+     + L  ++D    + EA
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1923

Query: 197  GGPPSTREAE-LKLRLKLVEEEANIL-----GRKIVE 227
             G    RE   LK +L+   E + +      GR+++E
Sbjct: 1924 MG----REVNALKSKLRRGNETSFVPSRRSGGRRVIE 1956


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 201/996 (20%), Positives = 383/996 (38%), Gaps = 108/996 (10%)

Query: 15   QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVR 74
            ++Q    EL +  +  +  +  L++ EQK  ++ E   +  E +++  +    A+++ VR
Sbjct: 860  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919

Query: 75   LHHELKTVEE--KRAKAEDENETLRQQMIEVEISKQA-----LQNELERLKESSLKRRST 127
            L  + + +EE     +A  E E  R Q ++ E  K A     L+ +LE  + +  K +  
Sbjct: 920  LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 979

Query: 128  REMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLG---REKDELEQELQKYKSLY 184
            +   + K    +D+   +  Q     +E  L+ ++++ L     E++E  + L K K+ +
Sbjct: 980  KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039

Query: 185  GDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRG 244
              + S L         S +E E KL+ KL E +A+    +I +L+ +   LK ++     
Sbjct: 1040 ESMISELEVRLKKEEKSRQELE-KLKRKL-EGDASDFHEQIADLQAQIAELKMQL----A 1093

Query: 245  QQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTH 304
            ++E E            +   ++L+   EL  H+  ++E+ +  R + ++ E   R L  
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153

Query: 305  ELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLS 364
            EL   K E       L +     A      Q+EL++ R Q   +  K L  +  +H    
Sbjct: 1154 ELEALKTE-------LEDTLDSTA-----TQQELRAKREQEVTVLKKALDEETRSHEAQV 1201

Query: 365  NIQRC-------DLAAHLGLRAPSPRDSDAESDAGKKES---DGEESRLPQPKREGPVGG 414
               R        +L   L     +  + D      +KE+    GE   L Q K+E     
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261

Query: 415  ESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQ------------ 462
            +    ++ E  S    G+ + A      ++ K + + E +  + +EA+            
Sbjct: 1262 KKLEAQVQELQSKCSDGERARAE--LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319

Query: 463  ---RLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGE-EEQGEGDQQEPQLLGTINAK 518
               +L+ T E L  +T   L+ +            LQ + +E+ E  Q   + + T+N +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379

Query: 519  MKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQS 578
            +   KK+LQ F   V  + +G            F   + ++++        K    D   
Sbjct: 1380 LSDSKKKLQDFASTVEALEEG---------KKRFQKEIENLTQQYE----EKAAAYDKLE 1426

Query: 579  RLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLEL-RGPPVLP 637
            + K +L+ +L     D     +L +  E  +R      +      + ++ E  R      
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486

Query: 638  EQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEHLYALR------WKELEMHSLAL 691
            E+      L   L +A  L  +E    TNK+ K E E L + +        ELE    AL
Sbjct: 1487 EKETKALSLARALEEA--LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1544

Query: 692  QNTLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHP 751
            +  + E     E+  ++ EL++ +       V ++ L   + +  Q  +E  E    +  
Sbjct: 1545 ETQMEEMKTQLEE--LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602

Query: 752  ETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPH- 810
              L           ++ +  D    R                + D  L+  +A +G+   
Sbjct: 1603 RQLHE---------YETELEDERKQRAL---AAAAKKKLEGDLKDLELQADSAIKGREEA 1650

Query: 811  -KQVVENQQLFSAFKALLEDFRA---ELREDERARLRLQQQYASDKAAWDVEWAVLKCRL 866
             KQ+ + Q     F+  LED RA   E+    +   +  +   +D      + A  +   
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710

Query: 867  EQLEEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREK 926
            +Q + + E    EL SS   + AL+ E+   ++L A    L  +L       E+  N E 
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEK---RRLEARIAQLEEEL------EEEQGNMEA 1761

Query: 927  VELLDRLDRDRQEWERQKKEFLWRIEQLQKENSPRR 962
            +   DR+ +  Q+ E+   E        QK  S R+
Sbjct: 1762 MS--DRVRKATQQAEQLSNELATERSTAQKNESARQ 1795



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 88/398 (22%), Positives = 163/398 (40%), Gaps = 43/398 (10%)

Query: 6    DSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDL 65
            ++ LEE+  + Q+L+ E  +  +    L+ +L + E    K+          I+ LE ++
Sbjct: 935  EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 994

Query: 66   KVAKDVSVRLHHELKTVEEKRAKAED---ENETLRQQMIEVEISKQALQNELE-RLKESS 121
             V  D + +L  E K +EE+ +       E E   + + +++   +++ +ELE RLK+  
Sbjct: 995  LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK-- 1052

Query: 122  LKRRSTREMYKEKKTFNQDDS------ADLRCQL-----QFAKEEAFLMRKKMAKLGREK 170
             + +S +E+ K K+    D S      ADL+ Q+     Q AK+E  L     A L R  
Sbjct: 1053 -EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ----AALARLD 1107

Query: 171  DELEQE---LQKYKSLYG-------DVDSPLPTG--------EAGGPPSTREAELKLRLK 212
            DE+ Q+   L+K + L G       D+DS             + G      + EL+  L 
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167

Query: 213  LVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESST 272
                +  +  ++  E+ V  + L  E      Q +        A    T        +  
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227

Query: 273  ELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGA 332
             L ++ Q +E+E   L   +  +    +++ H+  K + +         +G    A    
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287

Query: 333  P---LQEELKSARLQISELSGKVLKLQHENHALLSNIQ 367
                LQ E++S    ++E  GK +KL  +  +L S +Q
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 181/927 (19%), Positives = 367/927 (39%), Gaps = 151/927 (16%)

Query: 56   ELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQM-IEVEISKQALQNEL 114
            E +++ E +L+  K+   +  +ELK +E+K ++  +E   L++Q+  E E+  +A   E 
Sbjct: 859  EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA---EE 915

Query: 115  ERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELE 174
             R++ ++ K+     +++ +    +++    + Q +         RKKMA   ++  +LE
Sbjct: 916  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE---------RKKMA---QQMLDLE 963

Query: 175  QELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRG 234
            ++L++ ++    +     T EA             ++K +E+E  ++  +  +L  E + 
Sbjct: 964  EQLEEEEAARQKLQLEKVTAEA-------------KIKKLEDEILVMDDQNNKLSKERKL 1010

Query: 235  LKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELR-RHLQFVEEEAELLRRSIS 293
            L+  + D+      E                +  ++ T+L+ +H   + E    L++   
Sbjct: 1011 LEERISDLTTNLAEE---------------EEKAKNLTKLKNKHESMISELEVRLKK--- 1052

Query: 294  EIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVL 353
              E+ +RQ   EL K K +                G  +   E++   + QI+EL  ++ 
Sbjct: 1053 --EEKSRQ---ELEKLKRKL--------------EGDASDFHEQIADLQAQIAELKMQLA 1093

Query: 354  KLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEE-SRLPQPKREGPV 412
            K + E  A L+ +   D  A         R+ +      +++ D E  +R    K++  +
Sbjct: 1094 KKEEELQAALARLD--DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151

Query: 413  GGESDS--EEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLE----- 465
            G E ++   E+ +      + +   A       +LK   D E   T  HEAQ  E     
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE---TRSHEAQVQEMRQKH 1208

Query: 466  -RTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKK 524
             + VE L    + F      R  A L     Q  E++      E ++LG    +++  KK
Sbjct: 1209 AQAVEELTEQLEQF-----KRAKANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262

Query: 525  ELQAFLEQV-NRIGDGLSPLPHLTES----SSFLSTVTSVSRDS---------PIGNLGK 570
            +L+A ++++ ++  DG      L +      + + +VT +  ++          + +L  
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322

Query: 571  ELGPDLQSRLKEQLEWQLGPAR-----GDERESLRLRAARELHRRADGDTGSHGLGGQTC 625
            +L  D Q  L+E+   +L  +       +ER SL+ +   E+  + + +     L  Q  
Sbjct: 1323 QL-QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381

Query: 626  FSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEHLYALRWKELE 685
             S +      L + + ++E L+    +  +  Q+E E  T +  +       A  + +LE
Sbjct: 1382 DSKK-----KLQDFASTVEALE----EGKKRFQKEIENLTQQYEEK------AAAYDKLE 1426

Query: 686  MHSLALQNTLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWR--QGKQMEEEGE 743
                 LQ  L      D+  +     R L  N+     K   LL   +    K  +E   
Sbjct: 1427 KTKNRLQQEL------DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480

Query: 744  EFTEGEHPET----LSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSL 799
               E    ET    L+R  E  ++   + +  +            E    S+  +G +  
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM-----EDLVSSKDDVGKNVH 1535

Query: 800  RLQTADRGQPHKQVVENQQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEW 859
             L+ +      K+ +E Q      K  LE+   EL+  E A+LRL+    + K  ++ + 
Sbjct: 1536 ELEKS------KRALETQ--MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD- 1586

Query: 860  AVLKCRLEQLEEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSE 919
              L+ R EQ EEK      +L          +K+R +           + DL  Q   + 
Sbjct: 1587 --LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644

Query: 920  KNWNREKVELLDRLDRDRQEWERQKKE 946
            K    E ++ L +L    ++++R+ ++
Sbjct: 1645 KG-REEAIKQLRKLQAQMKDFQRELED 1670



 Score = 54.7 bits (130), Expect = 7e-07
 Identities = 145/670 (21%), Positives = 264/670 (39%), Gaps = 94/670 (14%)

Query: 9    LEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVA 68
            L   +   QEL +E  R   N   +  +LR+ E++   + +    + E  ++LE+ +   
Sbjct: 1320 LSSQLQDTQELLQEETRQKLN---VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376

Query: 69   K----DVSVRLHHELKTVE---EKRAKAEDENETLRQQMIE-------VEISKQALQNEL 114
                 D   +L     TVE   E + + + E E L QQ  E       +E +K  LQ EL
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436

Query: 115  ERLK-ESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDEL 173
            + L  +   +R+    + K+++ F+Q              EE  +  K   +  R + E 
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQ-----------LLAEEKNISSKYADERDRAEAEA 1485

Query: 174  EQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENR 233
             ++  K  SL   ++  L   EA          LK  ++ +    + +G+ + ELE   R
Sbjct: 1486 REKETKALSLARALEEAL---EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542

Query: 234  GLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEE------EAEL 287
             L+ +ME+M+ Q E                  D L+++ + +  L+   +      E +L
Sbjct: 1543 ALETQMEEMKTQLEE---------------LEDELQATEDAKLRLEVNMQALKGQFERDL 1587

Query: 288  LRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQI-S 346
              R   + E+  RQL  +L +++ E   E     +  +  A     L+ +LK   LQ  S
Sbjct: 1588 QARD-EQNEEKRRQLQRQLHEYETELEDE----RKQRALAAAAKKKLEGDLKDLELQADS 1642

Query: 347  ELSGK--VLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLP 404
             + G+   +K   +  A + + QR      L     S  +  A +   +K++   E+ L 
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQR-----ELEDARASRDEIFATAKENEKKAKSLEADLM 1697

Query: 405  QPKREGPVG------GESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLK 458
            Q + +           + + EE+ E+ +   SG+ +   E    E   A+ + E    L+
Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE----LE 1753

Query: 459  HEAQRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQE-----PQLLG 513
             E   +E   +R+   T      +             +   +Q E   +E      ++ G
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813

Query: 514  TINAKMKAFKKELQAFLEQV-----NRIGDGLSPLPHLTESSSFLSTV-TSVSRDSPIGN 567
             + +K K+    L+A + Q+         +  +    L +    L  +   V  +  +  
Sbjct: 1814 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE 1873

Query: 568  LGKELGPDLQSRLKEQLEWQLGPARGDERESLRLRA-ARELHRRADGDTGSHGLGGQTCF 626
              KE      +R+K QL+ QL  A   E ES R+ A  R+L R  D  T S+   G+   
Sbjct: 1874 QYKEQAEKGNARVK-QLKRQLEEA---EEESQRINANRRKLQRELDEATESNEAMGREVN 1929

Query: 627  SL--ELRGPP 634
            +L  +LRGPP
Sbjct: 1930 ALKSKLRGPP 1939



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 54/242 (22%), Positives = 100/242 (41%), Gaps = 48/242 (19%)

Query: 3    EMRDSYLEEDVYQLQELRRELDRANKNCRI------------------LQYRLRKAEQKS 44
            E +   LE D+ QLQE     +RA K   +                  LQ   R+ E + 
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1745

Query: 45   LKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTV-------EEKRAKAEDENETLR 97
             ++ E  + +   + ++   ++ A   + +L +EL T        E  R + E +N+ LR
Sbjct: 1746 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1805

Query: 98   QQMIEVEISKQ--------ALQNELERLKESSLKRRSTREMYKEKKTFNQDDS------- 142
             ++ E+E + +        AL+ ++ +L+E     +  RE     K+  Q D        
Sbjct: 1806 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ--VEQEAREKQAATKSLKQKDKKLKEILL 1863

Query: 143  --ADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKY----KSLYGDVDSPLPTGEA 196
               D R   +  KE+A     ++ +L R+ +E E+E Q+     + L  ++D    + EA
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1923

Query: 197  GG 198
             G
Sbjct: 1924 MG 1925


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 201/996 (20%), Positives = 383/996 (38%), Gaps = 108/996 (10%)

Query: 15   QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVR 74
            ++Q    EL +  +  +  +  L++ EQK  ++ E   +  E +++  +    A+++ VR
Sbjct: 853  EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912

Query: 75   LHHELKTVEE--KRAKAEDENETLRQQMIEVEISKQA-----LQNELERLKESSLKRRST 127
            L  + + +EE     +A  E E  R Q ++ E  K A     L+ +LE  + +  K +  
Sbjct: 913  LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 972

Query: 128  REMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLG---REKDELEQELQKYKSLY 184
            +   + K    +D+   +  Q     +E  L+ ++++ L     E++E  + L K K+ +
Sbjct: 973  KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032

Query: 185  GDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRG 244
              + S L         S +E E KL+ KL E +A+    +I +L+ +   LK ++     
Sbjct: 1033 ESMISELEVRLKKEEKSRQELE-KLKRKL-EGDASDFHEQIADLQAQIAELKMQL----A 1086

Query: 245  QQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTH 304
            ++E E            +   ++L+   EL  H+  ++E+ +  R + ++ E   R L  
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146

Query: 305  ELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLS 364
            EL   K E       L +     A      Q+EL++ R Q   +  K L  +  +H    
Sbjct: 1147 ELEALKTE-------LEDTLDSTA-----TQQELRAKREQEVTVLKKALDEETRSHEAQV 1194

Query: 365  NIQRC-------DLAAHLGLRAPSPRDSDAESDAGKKES---DGEESRLPQPKREGPVGG 414
               R        +L   L     +  + D      +KE+    GE   L Q K+E     
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1254

Query: 415  ESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQ------------ 462
            +    ++ E  S    G+ + A      ++ K + + E +  + +EA+            
Sbjct: 1255 KKLEAQVQELQSKCSDGERARAE--LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312

Query: 463  ---RLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGE-EEQGEGDQQEPQLLGTINAK 518
               +L+ T E L  +T   L+ +            LQ + +E+ E  Q   + + T+N +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372

Query: 519  MKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQS 578
            +   KK+LQ F   V  + +G            F   + ++++        K    D   
Sbjct: 1373 LSDSKKKLQDFASTVEALEEG---------KKRFQKEIENLTQQYE----EKAAAYDKLE 1419

Query: 579  RLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLEL-RGPPVLP 637
            + K +L+ +L     D     +L +  E  +R      +      + ++ E  R      
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479

Query: 638  EQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEHLYALR------WKELEMHSLAL 691
            E+      L   L +A  L  +E    TNK+ K E E L + +        ELE    AL
Sbjct: 1480 EKETKALSLARALEEA--LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1537

Query: 692  QNTLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHP 751
            +  + E     E+  ++ EL++ +       V ++ L   + +  Q  +E  E    +  
Sbjct: 1538 ETQMEEMKTQLEE--LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595

Query: 752  ETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPH- 810
              L           ++ +  D    R                + D  L+  +A +G+   
Sbjct: 1596 RQLHE---------YETELEDERKQRAL---AAAAKKKLEGDLKDLELQADSAIKGREEA 1643

Query: 811  -KQVVENQQLFSAFKALLEDFRA---ELREDERARLRLQQQYASDKAAWDVEWAVLKCRL 866
             KQ+ + Q     F+  LED RA   E+    +   +  +   +D      + A  +   
Sbjct: 1644 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703

Query: 867  EQLEEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREK 926
            +Q + + E    EL SS   + AL+ E+   ++L A    L  +L       E+  N E 
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEK---RRLEARIAQLEEEL------EEEQGNMEA 1754

Query: 927  VELLDRLDRDRQEWERQKKEFLWRIEQLQKENSPRR 962
            +   DR+ +  Q+ E+   E        QK  S R+
Sbjct: 1755 MS--DRVRKATQQAEQLSNELATERSTAQKNESARQ 1788



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 88/398 (22%), Positives = 163/398 (40%), Gaps = 43/398 (10%)

Query: 6    DSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDL 65
            ++ LEE+  + Q+L+ E  +  +    L+ +L + E    K+          I+ LE ++
Sbjct: 928  EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 987

Query: 66   KVAKDVSVRLHHELKTVEEKRAKAED---ENETLRQQMIEVEISKQALQNELE-RLKESS 121
             V  D + +L  E K +EE+ +       E E   + + +++   +++ +ELE RLK+  
Sbjct: 988  LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK-- 1045

Query: 122  LKRRSTREMYKEKKTFNQDDS------ADLRCQL-----QFAKEEAFLMRKKMAKLGREK 170
             + +S +E+ K K+    D S      ADL+ Q+     Q AK+E  L     A L R  
Sbjct: 1046 -EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ----AALARLD 1100

Query: 171  DELEQE---LQKYKSLYG-------DVDSPLPTG--------EAGGPPSTREAELKLRLK 212
            DE+ Q+   L+K + L G       D+DS             + G      + EL+  L 
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160

Query: 213  LVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESST 272
                +  +  ++  E+ V  + L  E      Q +        A    T        +  
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220

Query: 273  ELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGA 332
             L ++ Q +E+E   L   +  +    +++ H+  K + +         +G    A    
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280

Query: 333  P---LQEELKSARLQISELSGKVLKLQHENHALLSNIQ 367
                LQ E++S    ++E  GK +KL  +  +L S +Q
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 181/927 (19%), Positives = 367/927 (39%), Gaps = 151/927 (16%)

Query: 56   ELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQM-IEVEISKQALQNEL 114
            E +++ E +L+  K+   +  +ELK +E+K ++  +E   L++Q+  E E+  +A   E 
Sbjct: 852  EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA---EE 908

Query: 115  ERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELE 174
             R++ ++ K+     +++ +    +++    + Q +         RKKMA   ++  +LE
Sbjct: 909  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE---------RKKMA---QQMLDLE 956

Query: 175  QELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRG 234
            ++L++ ++    +     T EA             ++K +E+E  ++  +  +L  E + 
Sbjct: 957  EQLEEEEAARQKLQLEKVTAEA-------------KIKKLEDEILVMDDQNNKLSKERKL 1003

Query: 235  LKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELR-RHLQFVEEEAELLRRSIS 293
            L+  + D+      E                +  ++ T+L+ +H   + E    L++   
Sbjct: 1004 LEERISDLTTNLAEE---------------EEKAKNLTKLKNKHESMISELEVRLKK--- 1045

Query: 294  EIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVL 353
              E+ +RQ   EL K K +                G  +   E++   + QI+EL  ++ 
Sbjct: 1046 --EEKSRQ---ELEKLKRKL--------------EGDASDFHEQIADLQAQIAELKMQLA 1086

Query: 354  KLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEE-SRLPQPKREGPV 412
            K + E  A L+ +   D  A         R+ +      +++ D E  +R    K++  +
Sbjct: 1087 KKEEELQAALARLD--DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144

Query: 413  GGESDS--EEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLE----- 465
            G E ++   E+ +      + +   A       +LK   D E   T  HEAQ  E     
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE---TRSHEAQVQEMRQKH 1201

Query: 466  -RTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKK 524
             + VE L    + F      R  A L     Q  E++      E ++LG    +++  KK
Sbjct: 1202 AQAVEELTEQLEQF-----KRAKANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255

Query: 525  ELQAFLEQV-NRIGDGLSPLPHLTES----SSFLSTVTSVSRDS---------PIGNLGK 570
            +L+A ++++ ++  DG      L +      + + +VT +  ++          + +L  
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315

Query: 571  ELGPDLQSRLKEQLEWQLGPAR-----GDERESLRLRAARELHRRADGDTGSHGLGGQTC 625
            +L  D Q  L+E+   +L  +       +ER SL+ +   E+  + + +     L  Q  
Sbjct: 1316 QL-QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374

Query: 626  FSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEHLYALRWKELE 685
             S +      L + + ++E L+    +  +  Q+E E  T +  +       A  + +LE
Sbjct: 1375 DSKK-----KLQDFASTVEALE----EGKKRFQKEIENLTQQYEEK------AAAYDKLE 1419

Query: 686  MHSLALQNTLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWR--QGKQMEEEGE 743
                 LQ  L      D+  +     R L  N+     K   LL   +    K  +E   
Sbjct: 1420 KTKNRLQQEL------DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473

Query: 744  EFTEGEHPET----LSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSL 799
               E    ET    L+R  E  ++   + +  +            E    S+  +G +  
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM-----EDLVSSKDDVGKNVH 1528

Query: 800  RLQTADRGQPHKQVVENQQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEW 859
             L+ +      K+ +E Q      K  LE+   EL+  E A+LRL+    + K  ++ + 
Sbjct: 1529 ELEKS------KRALETQ--MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD- 1579

Query: 860  AVLKCRLEQLEEKTENKLGELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSE 919
              L+ R EQ EEK      +L          +K+R +           + DL  Q   + 
Sbjct: 1580 --LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637

Query: 920  KNWNREKVELLDRLDRDRQEWERQKKE 946
            K    E ++ L +L    ++++R+ ++
Sbjct: 1638 KG-REEAIKQLRKLQAQMKDFQRELED 1663



 Score = 54.7 bits (130), Expect = 7e-07
 Identities = 145/670 (21%), Positives = 264/670 (39%), Gaps = 94/670 (14%)

Query: 9    LEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVA 68
            L   +   QEL +E  R   N   +  +LR+ E++   + +    + E  ++LE+ +   
Sbjct: 1313 LSSQLQDTQELLQEETRQKLN---VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369

Query: 69   K----DVSVRLHHELKTVE---EKRAKAEDENETLRQQMIE-------VEISKQALQNEL 114
                 D   +L     TVE   E + + + E E L QQ  E       +E +K  LQ EL
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429

Query: 115  ERLK-ESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDEL 173
            + L  +   +R+    + K+++ F+Q              EE  +  K   +  R + E 
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQ-----------LLAEEKNISSKYADERDRAEAEA 1478

Query: 174  EQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENR 233
             ++  K  SL   ++  L   EA          LK  ++ +    + +G+ + ELE   R
Sbjct: 1479 REKETKALSLARALEEAL---EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535

Query: 234  GLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEE------EAEL 287
             L+ +ME+M+ Q E                  D L+++ + +  L+   +      E +L
Sbjct: 1536 ALETQMEEMKTQLEE---------------LEDELQATEDAKLRLEVNMQALKGQFERDL 1580

Query: 288  LRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQI-S 346
              R   + E+  RQL  +L +++ E   E     +  +  A     L+ +LK   LQ  S
Sbjct: 1581 QARD-EQNEEKRRQLQRQLHEYETELEDE----RKQRALAAAAKKKLEGDLKDLELQADS 1635

Query: 347  ELSGK--VLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLP 404
             + G+   +K   +  A + + QR      L     S  +  A +   +K++   E+ L 
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQR-----ELEDARASRDEIFATAKENEKKAKSLEADLM 1690

Query: 405  QPKREGPVG------GESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLK 458
            Q + +           + + EE+ E+ +   SG+ +   E    E   A+ + E    L+
Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE----LE 1746

Query: 459  HEAQRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQE-----PQLLG 513
             E   +E   +R+   T      +             +   +Q E   +E      ++ G
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806

Query: 514  TINAKMKAFKKELQAFLEQV-----NRIGDGLSPLPHLTESSSFLSTV-TSVSRDSPIGN 567
             + +K K+    L+A + Q+         +  +    L +    L  +   V  +  +  
Sbjct: 1807 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE 1866

Query: 568  LGKELGPDLQSRLKEQLEWQLGPARGDERESLRLRA-ARELHRRADGDTGSHGLGGQTCF 626
              KE      +R+K QL+ QL  A   E ES R+ A  R+L R  D  T S+   G+   
Sbjct: 1867 QYKEQAEKGNARVK-QLKRQLEEA---EEESQRINANRRKLQRELDEATESNEAMGREVN 1922

Query: 627  SL--ELRGPP 634
            +L  +LRGPP
Sbjct: 1923 ALKSKLRGPP 1932



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 54/242 (22%), Positives = 100/242 (41%), Gaps = 48/242 (19%)

Query: 3    EMRDSYLEEDVYQLQELRRELDRANKNCRI------------------LQYRLRKAEQKS 44
            E +   LE D+ QLQE     +RA K   +                  LQ   R+ E + 
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1738

Query: 45   LKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTV-------EEKRAKAEDENETLR 97
             ++ E  + +   + ++   ++ A   + +L +EL T        E  R + E +N+ LR
Sbjct: 1739 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1798

Query: 98   QQMIEVEISKQ--------ALQNELERLKESSLKRRSTREMYKEKKTFNQDDS------- 142
             ++ E+E + +        AL+ ++ +L+E     +  RE     K+  Q D        
Sbjct: 1799 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ--VEQEAREKQAATKSLKQKDKKLKEILL 1856

Query: 143  --ADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKY----KSLYGDVDSPLPTGEA 196
               D R   +  KE+A     ++ +L R+ +E E+E Q+     + L  ++D    + EA
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1916

Query: 197  GG 198
             G
Sbjct: 1917 MG 1918


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 156/723 (21%), Positives = 288/723 (39%), Gaps = 107/723 (14%)

Query: 15   QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGEL---------------IR 59
            Q+ +L   L++  K C  L+   RK E   LK+A+   +D E                + 
Sbjct: 1034 QVDDLEGSLEQEKKLCMDLERAKRKLEG-DLKLAQESTMDTENDKQQLNEKLKKKEFEMS 1092

Query: 60   SLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNEL----E 115
            +L+  ++  + ++++L  ++K ++ +  + E+E E  R    + E  +  L  EL    E
Sbjct: 1093 NLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISE 1152

Query: 116  RLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKK----MAKLG---- 167
            RL+E+     +  EM K+++   Q    DL       +  A  +RKK    +A+LG    
Sbjct: 1153 RLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQID 1212

Query: 168  ---REKDELEQELQKYKSLYGDVDSPLPT---GEAGGPPSTREAELKL-RLKLVEEE--- 217
               R K +LE+E  + K    D+ S + T    +A      R  E +L  +K  EEE   
Sbjct: 1213 SLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQR 1272

Query: 218  -ANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTE--- 273
              N L  +   L  E+     ++++      +   G+  A +         LE  T+   
Sbjct: 1273 LINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGK-QAFTQQIEELKRQLEEETKAKS 1331

Query: 274  -LRRHLQFVEEEAELLRRSISEIEDHNRQLTHELS-----------KFKFEPPREPGWLG 321
             L   LQ    + +LLR    E ++   +L   +S           K++ +  +    L 
Sbjct: 1332 TLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELE 1391

Query: 322  EGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPS 381
            E     A      +E +++   + + L     +LQ+E   L+ +++R + AA + L    
Sbjct: 1392 EAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSN-AACIAL-DKK 1449

Query: 382  PRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCP 441
             R+ D      K++ +  ++ L   ++E      S S E+F+  + +             
Sbjct: 1450 QRNFDKVLAEWKQKYEETQAELEASQKE----SRSLSTELFKVKNAY------------- 1492

Query: 442  TELLKAREDSEYLVTLKHEAQRLERTVERL---ITDTDSFLHD-AGLRGGAPLPGPGLQG 497
                   E  ++L TLK E + L++ +  L   I +    +H+   ++         LQ 
Sbjct: 1493 ------EESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQT 1546

Query: 498  EEEQGEG--DQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLST 555
              E+ E   + +E ++L  I  ++   K E+   + + +   D L    HL    S  ST
Sbjct: 1547 SLEEAEASLEHEEGKIL-RIQLELNQVKSEIDRKIAEKDEELDQLK-RNHLRVVESMQST 1604

Query: 556  VTSVSRD-SPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLR-LRAARELHRRADG 613
            + +  R  +    + K++  DL      ++E QL  A     E+LR LR  + + +    
Sbjct: 1605 LDAEIRSRNDALRIKKKMEGDL-----NEMEIQLNHANRQAAEALRNLRNTQGILK---- 1655

Query: 614  DTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEE 673
            DT  H           +RG   L EQ   +E  +  L+QA       +   T +  KM E
Sbjct: 1656 DTQLH-------LDDAIRGQDDLKEQLAMVER-RANLMQAEVEELRASLERTERGRKMAE 1707

Query: 674  EHL 676
            + L
Sbjct: 1708 QEL 1710



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 181/1008 (17%), Positives = 370/1008 (36%), Gaps = 145/1008 (14%)

Query: 15   QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVR 74
            +  EL++++D        ++      E K   + E      E I  L ++ K  ++   +
Sbjct: 950  ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009

Query: 75   LHHELKTVEEK-------RAKAEDENETLRQQM-------IEVEISKQALQNELERLKES 120
               +L+  E+K       + K E + + L   +       +++E +K+ L+ +L+  +ES
Sbjct: 1010 TLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQES 1069

Query: 121  SLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKY 180
            ++   + ++   EK    + + ++L+ +++  +  A  ++KK+ +L    +ELE+E++  
Sbjct: 1070 TMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAE 1129

Query: 181  KSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKI---VELEVENRGLKA 237
            ++            +A    S    EL+   + +EE       +I    + E E + ++ 
Sbjct: 1130 RA---------SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1180

Query: 238  EMEDMRGQQEREGPG--RDHAPSIPTSPFGDSLES-----------STELRRHLQFVEEE 284
            ++E+   Q E       + HA S+  +  G+ ++S            +EL+  +  +   
Sbjct: 1181 DLEESTLQHEATAAALRKKHADSV--AELGEQIDSLQRVKQKLEKEKSELKMEINDLASN 1238

Query: 285  AELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQ 344
             E + ++ +  E   R L  +LS+ K +   +   + E ++      A L  E      Q
Sbjct: 1239 METVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQ----KARLHTESGEFSRQ 1294

Query: 345  ISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGK----KESDGEE 400
            + E    V +L     A    I+          +A S      +S        +E   EE
Sbjct: 1295 LDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEE 1354

Query: 401  SRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHE 460
                   + G     S+  +   K       +  E  E       + ++  E++  +  +
Sbjct: 1355 QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSK 1414

Query: 461  AQRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQG-------------EEEQG--EGD 505
               LE+T +RL  + +  + D      A +     Q              EE Q   E  
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEAS 1474

Query: 506  QQEPQLLG------------------TINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLT 547
            Q+E + L                   T+  + K  ++E+    EQ+   G  +  L  + 
Sbjct: 1475 QKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVK 1534

Query: 548  ESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLK-EQLEWQLGPARGDERESL------R 600
            +      +    S +    +L  E G  L+ +L+  Q++ ++     ++ E L       
Sbjct: 1535 KQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNH 1594

Query: 601  LRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEE 660
            LR    +    D +  S          ++ +    L E  + +     Q  +A R  +  
Sbjct: 1595 LRVVESMQSTLDAEIRSR----NDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRN- 1649

Query: 661  TETFTNKIHKMEEEHL-YALRWKELEMHSLALQNTLHERTWSDEKNLMQQELRSLKQNIF 719
                T  I K  + HL  A+R ++     L  Q  + ER      NLMQ E+  L+ ++ 
Sbjct: 1650 ----TQGILKDTQLHLDDAIRGQD----DLKEQLAMVER----RANLMQAEVEELRASL- 1696

Query: 720  LFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGC 779
                             +  E G +  E E  +   R+  L  Q     +          
Sbjct: 1697 -----------------ERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKK------ 1733

Query: 780  GFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFSAFKALLEDFRAELREDER 839
                   +  S++Q     +  +  +  +  K+ + +  + +      +D  A L   ER
Sbjct: 1734 -----LETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL---ER 1785

Query: 840  ARLRLQQQYASDKAAWD-VEWAVLKCRLEQLEEKTENKLGELGSSAESKGALKKEREVHQ 898
             +  ++Q     +   D  E   LK   +Q+ +K E ++ EL S  ES+   +K      
Sbjct: 1786 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQI-QKLEARVRELESEVESE---QKHNVEAV 1841

Query: 899  KLLADSHSLVMDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKE 946
            K L      V +L +Q     KN  R + +L+D+L    + ++RQ +E
Sbjct: 1842 KGLRKHERRVKELTYQTEEDRKNILRLQ-DLVDKLQTKVKAYKRQAEE 1888



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 179/873 (20%), Positives = 331/873 (37%), Gaps = 114/873 (13%)

Query: 102  EVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRK 161
            E E     ++ E E+ KE   K  + R+  +EK      +  DL+ Q+Q   +      +
Sbjct: 848  ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEE 907

Query: 162  KMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANIL 221
            +  +L + K +LE ++++      D +                AEL  + + +E+E + L
Sbjct: 908  RCDQLIKTKIQLEAKIKEVTERAEDEEE-------------INAELTAKKRKLEDECSEL 954

Query: 222  GRKIVELEVENRGLKAE---MEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHL 278
             + I +LE+    ++ E    E+       E  G D   +  T       E+  +    L
Sbjct: 955  KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1014

Query: 279  QFVEEEAELLRRSISEIE----------DHNRQLTHELSKFKFEPPREPGWLGEGASPGA 328
            Q  E++   L ++ +++E          +  ++L  +L + K +   +     E      
Sbjct: 1015 QMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTE 1074

Query: 329  GGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAE 388
                 L E+LK    ++S L GK+     +  AL   +Q+              ++  A 
Sbjct: 1075 NDKQQLNEKLKKKEFEMSNLQGKI----EDEQALAIQLQK------------KIKELQAR 1118

Query: 389  SDAGKKESDGEE-SRLPQPKREGPVGGE-SDSEEMFEKTSGFGSGKPSEASEPCPTELLK 446
             +  ++E + E  SR    K+   +  E  +  E  E+  G  S +  E ++    E  K
Sbjct: 1119 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQ-IEMNKKREAEFQK 1177

Query: 447  AREDSEYLVTLKHEA------QRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEE 500
             R D E   TL+HEA      ++   +V  L    DS                 LQ  ++
Sbjct: 1178 MRRDLEE-STLQHEATAAALRKKHADSVAELGEQIDS-----------------LQRVKQ 1219

Query: 501  QGEGDQQEPQL-LGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSV 559
            + E ++ E ++ +  + + M+   K    F +    + D LS +    E    L    S 
Sbjct: 1220 KLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSA 1279

Query: 560  SRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLRLRAARELHRRADGDTG--- 616
             +      L  E G +   +L E+       +RG +  + ++    EL R+ + +T    
Sbjct: 1280 QK----ARLHTESG-EFSRQLDEKDAMVSQLSRGKQAFTQQI---EELKRQLEEETKAKS 1331

Query: 617  --SHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEETETFTNKIHKMEE- 673
              +H L        +L       EQ    E  +G     + + Q  T+  T+ I + EE 
Sbjct: 1332 TLAHALQSAR-HDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEEL 1390

Query: 674  ---EHLYALRWKELEMHSLALQN------TLHERTWSDEKNLMQQELRSLKQNIFLFYVK 724
               +   A R ++ E H  A+ +         +R  ++ ++LM    RS    I L   K
Sbjct: 1391 EEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIAL-DKK 1449

Query: 725  LRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVG 784
             R   K   + KQ  EE +   E    E+ S   EL        +  DH         + 
Sbjct: 1450 QRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLE------TLK 1503

Query: 785  EHSPHSRVQIGDHSLRLQTADRGQP-HKQVVENQQL---FSAFKALLEDFRAELREDERA 840
              + + + +I D  L  Q A+ G+  H+     +QL    S  +  LE+  A L  +E  
Sbjct: 1504 RENKNLQQEISD--LTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGK 1561

Query: 841  RLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELGSSAESKGALKKEREVHQKL 900
             LR+Q +    K+  D + A    + E+L++   N L  + S   +  A  + R    ++
Sbjct: 1562 ILRIQLELNQVKSEIDRKIAE---KDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRI 1618

Query: 901  LADSHSLVMDLRWQIHHSEKNWNREKVELLDRL 933
                   + ++  Q++H+    NR+  E L  L
Sbjct: 1619 KKKMEGDLNEMEIQLNHA----NRQAAEALRNL 1647



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 97/551 (17%), Positives = 208/551 (37%), Gaps = 49/551 (8%)

Query: 3    EMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLE 62
            + R  Y  + + + +EL     +  +  +  +  +     K   + +T Q     +  L 
Sbjct: 1374 QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLM 1433

Query: 63   QDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSL 122
             D++ +    + L  + +  ++  A+ + + E  + ++   +   ++L  EL ++K +  
Sbjct: 1434 IDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYE 1493

Query: 123  KRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKS 182
            +     E  K +    Q + +DL  Q+    +    + K   +L  EK EL+  L++ ++
Sbjct: 1494 ESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEA 1553

Query: 183  LYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAE---- 238
                 +  +               L+++L+L + ++ I  RKI E + E   LK      
Sbjct: 1554 SLEHEEGKI---------------LRIQLELNQVKSEI-DRKIAEKDEELDQLKRNHLRV 1597

Query: 239  MEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDH 298
            +E M+   + E   R+ A  I     GD  E   +L    +   E    LR +   ++D 
Sbjct: 1598 VESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDT 1657

Query: 299  NRQL------THELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKV 352
               L        +L +      R    +              +   K A  ++ + S +V
Sbjct: 1658 QLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERV 1717

Query: 353  LKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPV 412
              L  +N +L++  ++               ++D     G+ E   +E+R  + K +  +
Sbjct: 1718 QLLHTQNTSLINTKKKL--------------ETDISQIQGEMEDIVQEARNAEEKAKKAI 1763

Query: 413  GGESDSEEMFEKTSGFGS--GKPSEASEPCPTELLKAREDSEYLVTL--KHEAQRLERTV 468
               +   E  +K     +   +  +  E    +L    +++E L     K + Q+LE  V
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARV 1823

Query: 469  ERLITDTDS-FLHDA----GLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFK 523
              L ++ +S   H+     GLR             EE  +   +   L+  +  K+KA+K
Sbjct: 1824 RELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYK 1883

Query: 524  KELQAFLEQVN 534
            ++ +   EQ N
Sbjct: 1884 RQAEEAEEQSN 1894



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 190/1042 (18%), Positives = 388/1042 (37%), Gaps = 176/1042 (16%)

Query: 1    MEEMRDSYLEEDVYQLQ----------ELRRELDRANKNCRILQYRLR-----------K 39
            +EEMRD  L + + + Q          E R+ ++R  ++   +QY +R           K
Sbjct: 777  LEEMRDEKLAQLITRTQAICRGFLMRVEFRKMMER-RESIFCIQYNIRAFMNVKHWPWMK 835

Query: 40   AEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKR------------- 86
               K   + ++ + + E+  +++++ +  K+   +   + K +EEK              
Sbjct: 836  LYFKIKPLLKSAETEKEMA-NMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQ 894

Query: 87   --------AKAEDENETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFN 138
                    A AE+  + L +  I++E   + +    E  +E + +  + +   +++ +  
Sbjct: 895  VQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 954

Query: 139  QDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGG 198
            + D  DL   L   ++E      K+  L  E   L++ + K             T E   
Sbjct: 955  KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL------------TKEKKA 1002

Query: 199  PPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPS 258
                 +  L   L++ E++ N L +   +LE        +++D+ G  E+E         
Sbjct: 1003 LQEAHQQTLD-DLQMEEDKVNTLTKAKTKLE-------QQVDDLEGSLEQE--------- 1045

Query: 259  IPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPG 318
                      +   +L R  + +E + +L + S  + E+  +QL  +L K +FE     G
Sbjct: 1046 ---------KKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQG 1096

Query: 319  WLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHL--- 375
             + +  +        LQ+++K  + +I EL  ++ + +  + A     QR DL+  L   
Sbjct: 1097 KIEDEQAL----AIQLQKKIKELQARIEELEEEI-EAERASRAKAEK-QRSDLSRELEEI 1150

Query: 376  ---------GLRAPSPRDSDAESDAGKKESDGEESRLPQPK-----REGPVGGESDSEEM 421
                        A    +   E++  K   D EES L         R+      ++  E 
Sbjct: 1151 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQ 1210

Query: 422  FEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHD 481
             +           E SE    E+     + E +   K   +++ RT+E  +++  +   +
Sbjct: 1211 IDSLQRVKQKLEKEKSE-LKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKT-KEE 1268

Query: 482  AGLRGGAPLPGPGLQGEEEQGEGDQQ---EPQLLGTINAKMKAFKKELQAFLEQVNRIGD 538
               R    L     +   E GE  +Q   +  ++  ++   +AF ++++    Q+     
Sbjct: 1269 EQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETK 1328

Query: 539  GLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQL-----GPARG 593
              S L H  +S+     +     +        EL   +     E  +W+         R 
Sbjct: 1329 AKSTLAHALQSARHDCDLLREQYEEE-QEAKAELQRGMSKANSEVAQWRTKYETDAIQRT 1387

Query: 594  DERESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQA 653
            +E E  + + A+ L    D +     +  + C SLE            + + LQ + V+ 
Sbjct: 1388 EELEEAKKKLAQRLQ---DAEEHVEAVNSK-CASLE-----------KTKQRLQNE-VED 1431

Query: 654  ARLHQEETETFTNKIHKMEEEHLYAL-RWKELEMHSLALQNTLHERTWSDEKNLMQQELR 712
              +  E +      + K +      L  WK+            +E T + E    Q+E R
Sbjct: 1432 LMIDVERSNAACIALDKKQRNFDKVLAEWKQ-----------KYEETQA-ELEASQKESR 1479

Query: 713  SLKQNIFLFYVKLRWLLKHW----RQGKQMEEEGEEFTE--GEHPETLSRLGELGVQGGH 766
            SL   +F         L H     R+ K +++E  + TE   E  + +  L ++  Q  H
Sbjct: 1480 SLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDH 1539

Query: 767  QADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFSAFKAL 826
            +        +        E     R+Q+  + ++ +  DR    K   E  QL      +
Sbjct: 1540 EKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSE-IDRKIAEKD-EELDQLKRNHLRV 1597

Query: 827  LEDFRAELREDERAR---LRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELGSS 883
            +E  ++ L  + R+R   LR++++   D    ++          QL          L + 
Sbjct: 1598 VESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEI----------QLNHANRQAAEALRNL 1647

Query: 884  AESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVEL------LDRLDRDR 937
              ++G L K+ ++H   L D+     DL+ Q+   E+  N  + E+      L+R +R R
Sbjct: 1648 RNTQGIL-KDTQLH---LDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGR 1703

Query: 938  QEWERQKKEFLWRIEQLQKENS 959
            +  E++  +   R++ L  +N+
Sbjct: 1704 KMAEQELLDASERVQLLHTQNT 1725



 Score = 38.5 bits (88), Expect = 0.052
 Identities = 66/333 (19%), Positives = 135/333 (40%), Gaps = 31/333 (9%)

Query: 1    MEEMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRS 60
            +++++ ++L         L  E+   N   RI +       +  +++    +   E +R+
Sbjct: 1587 LDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRN 1646

Query: 61   LEQDLKVAKDVSVR----------LHHELKTVEEKRAKAEDENETLRQQMIEVEISKQAL 110
            L     + KD  +           L  +L  VE +    + E E LR  +   E  ++  
Sbjct: 1647 LRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMA 1706

Query: 111  QNELERLKE--SSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGR 168
            + EL    E    L  ++T  +  +KK   + D + ++ +++   +EA    +K  K   
Sbjct: 1707 EQELLDASERVQLLHTQNTSLINTKKKL--ETDISQIQGEMEDIVQEARNAEEKAKKAIT 1764

Query: 169  EKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRK-IVE 227
            +   + +EL+K +    D  + L   +     + +  +L+LRL   E+ A   G+K I +
Sbjct: 1765 DAAMMAEELKKEQ----DTSAHLERMKKNMEQTVK--DLQLRLDEAEQLALKGGKKQIQK 1818

Query: 228  LEVENRGLKAEMEDMRGQQEREGPG-RDHAPSIPTSPFGDSLESSTELRRH--LQFVEEE 284
            LE   R L++E+E  +        G R H   +    +    +    LR    +  ++ +
Sbjct: 1819 LEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTK 1878

Query: 285  AELLRRSISEIEDHN-------RQLTHELSKFK 310
             +  +R   E E+ +       R+L HEL + K
Sbjct: 1879 VKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAK 1911


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 81/351 (23%), Positives = 157/351 (44%), Gaps = 57/351 (16%)

Query: 3    EMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGEL---IR 59
            E  +  LE++  QL++ +++L++ NK  R      ++AE K   + E     G L    +
Sbjct: 814  EKENKSLEQETSQLEKDKKQLEKENKRLR------QQAEIKDTTLEENNVKIGNLEKENK 867

Query: 60   SLEQDLKVAKDVSVRLHHELKTVEE--KRAKAEDEN-ETLRQQMIEVEISKQALQNELER 116
            +L +++ + K+  VRL    K  +E  KRA  + +   TLR+ ++  ++  Q + N+LE+
Sbjct: 868  TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927

Query: 117  LKESSLKRRSTRE--MYKEKKTFNQDDS----------ADLRCQLQFAKEEAFLMRKKMA 164
            L     K    +E  ++ E+ T   DDS          + L+  L+  +E+   +  ++ 
Sbjct: 928  LTHELEKIGLNKERLLHDEQST---DDSRYKLLESKLESTLKKSLEIKEEKIAALEARLE 984

Query: 165  KLGREKDELEQELQKYKSLYGDV-----------DSPLPTGEAG-----GPPSTREAELK 208
            +      +L QEL+  K  Y  +            SP  +GE          +TRE  LK
Sbjct: 985  ESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTREL-LK 1043

Query: 209  LRLKLVEEEAN---------ILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSI 259
            ++ +L+E E N          L  ++ +LE +N  L+A++  +   Q +    ++   ++
Sbjct: 1044 VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL---QRQTVSLQEQNTTL 1100

Query: 260  PTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFK 310
             T      +E+ST   +    + + A+LL +  S +E+ N  +  E    K
Sbjct: 1101 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQ-SSLENENESVIKEREDLK 1150



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 113/543 (20%), Positives = 217/543 (39%), Gaps = 68/543 (12%)

Query: 1    MEEMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLR-KAEQKSLKVAETGQVDGELIR 59
            +E+  ++  E    Q++ L +E +  N+    L+ R +  AE +   + +  ++  E I+
Sbjct: 538  LEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 597

Query: 60   SLEQDLKVAKDVSVRLHHELKTVEEKRAKAED----------ENETLRQQMIEVEISKQ- 108
                 L   +    ++  EL+  +EK  +AE+          ENE L++++  ++I+ + 
Sbjct: 598  ETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEK 657

Query: 109  --ALQNELERLKESSLKRRSTREMYKE--------KKTFNQDDSADLRCQLQFAKEEAFL 158
              AL+ E   L+  + K + T + +K         +K  +Q D  +L  +L+   E    
Sbjct: 658  IEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL--ELRRNVESLKC 715

Query: 159  MRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGE----AGGPPSTREAELKLRLKLV 214
               KMA+L  E  ELE E ++ K     + +     E    +          L+  L+  
Sbjct: 716  ASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENS 775

Query: 215  EEEANILGRKIVELEVENRGLKAEMEDMR------GQQEREGPGRDHAPSIPTSPFGDSL 268
             ++   L  ++ +LE+EN+ L+  +E+++       Q E+E    +   S          
Sbjct: 776  NKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE 835

Query: 269  ESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKF------EPPREPGWLGE 322
            + +  LR+  +  +   E     I  +E  N+ L+ E+  +K       E  +E   L +
Sbjct: 836  KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK 895

Query: 323  GASPGAGGGAPLQEELKSARLQISELSGKVLKLQHE-------NHALLSNIQRCD----- 370
             A+        L+E+L S +L+  +++  + KL HE          LL + Q  D     
Sbjct: 896  RATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYK 955

Query: 371  -----LAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQ-----PKREGPVGGESDSEE 420
                 L + L        +  A  +A  +ES     +L Q      K    +    D E 
Sbjct: 956  LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEER 1015

Query: 421  MFEKTSGFG--SGKPSEASEPCPTELLKAR----EDSEYLVTLKHEAQRLERTVERLITD 474
            M + +        K    S+    ELLK +    E      TL+ E Q L+  +++L T 
Sbjct: 1016 MVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ 1075

Query: 475  TDS 477
             ++
Sbjct: 1076 NNN 1078



 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 187/924 (20%), Positives = 350/924 (37%), Gaps = 139/924 (15%)

Query: 88   KAEDENETLRQQMIEVEISKQALQNELERLKESSLK-RRSTREMYKEKKTFNQDDS---A 143
            K  +  + L  ++ + +   + L+ ELE   E  L  ++   +M  E K   Q++    +
Sbjct: 241  KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300

Query: 144  DLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTR 203
            D R    + ++E   +R+K  ++    D+LE E+ +YK    D++      E     +  
Sbjct: 301  DARSARMY-RDELDALREKAVRV----DKLESEVSRYKERLHDIEFYKARVEELKEDNQV 355

Query: 204  EAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSP 263
              E K  L+   E       K+ ELE EN  LKA++ DM                     
Sbjct: 356  LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDM--------------------- 394

Query: 264  FGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEG 323
                              E E ++ R+ I E+ + N  L     K   +     GW  E 
Sbjct: 395  ------------------EMERDMDRKKIEELMEENMTL-EMAQKQSMDESLHLGWELEQ 435

Query: 324  ASPGAGGGAPLQEELKSARLQISEL-SGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSP 382
             S  +      Q   KS   +++EL S ++LKL+ EN +L   ++         LR    
Sbjct: 436  ISRTSELSEAPQ---KSLGHEVNELTSSRLLKLEMENQSLTKTVEE--------LRTTVD 484

Query: 383  RDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPT 442
                  S   K E + +         E  +  E  S +  +  S     + ++  +   T
Sbjct: 485  SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544

Query: 443  ELLKAREDSE-YLVTLKHEAQRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEE- 500
                 RE+SE  +  L+ E + L +TV  L         +A ++         ++ E + 
Sbjct: 545  ----LRENSERQIKILEQENEHLNQTVSSL-RQRSQISAEARVK--------DIEKENKI 591

Query: 501  QGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFL-STVTSV 559
              E  ++    L  I  + +  KKEL+ + E+  R  +  + L HL + +  L   +T++
Sbjct: 592  LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651

Query: 560  -----------SRDSPIGNLGKELGPDLQS--RLKEQLEWQLGPARGDERESLRLRAARE 606
                         +S +    ++L   L S   L  QLE         + E+L LR   E
Sbjct: 652  KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711

Query: 607  LHRRADGDTGSHGLGGQTCFSLE---LRGPPVLPEQSVSIEEL----QGQLVQAARLHQE 659
              + A        L  +   S +    +G  +L       E L    QG  ++  RL Q+
Sbjct: 712  SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRL-QK 770

Query: 660  ETETFTNKIHKMEEEHLYALRWKELEMHSLALQNTLHERTWSDEK-NLMQQELRSLKQNI 718
              E    KI ++E E       ++LEM +  LQ  L E   S ++   +++E +SL+Q  
Sbjct: 771  TLENSNKKIQQLESE------LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQET 824

Query: 719  FLFYVKLRWLLKHWRQGKQ------------------MEEEGEEFTE--GEHPETLSRLG 758
                   + L K  ++ +Q                  +E+E +  ++  G + E+  RL 
Sbjct: 825  SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884

Query: 759  ELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQ 818
            EL  +          D            S   + Q  ++ L   T +     +++  N++
Sbjct: 885  ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL----EKIGLNKE 940

Query: 819  LFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLG 878
                 +   +D R +L E      +L+          + + A L+ RLE+     +    
Sbjct: 941  RLLHDEQSTDDSRYKLLES-----KLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQ 995

Query: 879  ELGSSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELLDRL---DR 935
            EL +  ++  ALK+ ++  + + +       D +W+    E    RE +++ DRL   +R
Sbjct: 996  ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQET--TRELLKVKDRLIEVER 1053

Query: 936  DRQEWERQKKEFLWRIEQLQKENS 959
            +    + +K+    +++QL+ +N+
Sbjct: 1054 NNATLQAEKQALKTQLKQLETQNN 1077



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 78/395 (19%), Positives = 159/395 (40%), Gaps = 71/395 (17%)

Query: 17   QELRRELDRANKNCRILQYRLRKAEQ----------KSLKVAETGQVDGELIRSLE---Q 63
            +EL  E ++  K   +L+   +K E+          ++ ++ +T +   + I+ LE   Q
Sbjct: 728  KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQ 787

Query: 64   DLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSLK 123
            DL++      +   ELK   ++  + E EN++L Q+  ++E  K+ L+ E +RL++ +  
Sbjct: 788  DLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEI 847

Query: 124  RRST--------------------------------REMYKEKKTFNQDDSADLRCQLQF 151
            + +T                                +E+ KE K   +  + D++  L  
Sbjct: 848  KDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK-TLVT 906

Query: 152  AKEEAFLMRKKMAKLGREKDELEQELQKY----KSLYGDVDSPLPTGEAGGPPSTREAEL 207
             +E+    + K  ++  + ++L  EL+K     + L  D  S           S  E+ L
Sbjct: 907  LREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQS-TDDSRYKLLESKLESTL 965

Query: 208  KLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDS 267
            K  L++ EE+   L  ++ E    N+ L+ E++ ++   E     +D    + +SP    
Sbjct: 966  KKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISG 1025

Query: 268  LESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPG 327
             ++  E  R  Q    E   ++  + E+E +N  L  E    K +  +            
Sbjct: 1026 EDNKWE--RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQ------------ 1071

Query: 328  AGGGAPLQEELKSARLQISELSGKVLKLQHENHAL 362
                  L+ +  + + QI  L  + + LQ +N  L
Sbjct: 1072 ------LETQNNNLQAQILALQRQTVSLQEQNTTL 1100



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 200/1022 (19%), Positives = 388/1022 (37%), Gaps = 211/1022 (20%)

Query: 9    LEEDVYQLQ------ELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGEL----- 57
            LE++  QL+      E+ R++DR  K    L       E  +L++A+   +D  L     
Sbjct: 380  LEKENLQLKAKLHDMEMERDMDR--KKIEELM-----EENMTLEMAQKQSMDESLHLGWE 432

Query: 58   IRSLEQDLKVAKDVSVRLHHELKTVEEKRA-KAEDENETLRQQMIEVEISKQALQNELER 116
            +  + +  ++++     L HE+  +   R  K E EN++L + + E+  +  +++    +
Sbjct: 433  LEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASK 492

Query: 117  -LKESSLKRRSTREMYKEKKTFNQDDSADLRCQ---LQFAKEEAFLMRKKMAKLGREKDE 172
             LK     +R ++++   +    Q+  +   CQ       KE+A L  +K  +  RE  E
Sbjct: 493  ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL--EKTIETLRENSE 550

Query: 173  LEQEL--QKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEV 230
             + ++  Q+ + L   V S     +       R  +++   K++ E       K+ ++E 
Sbjct: 551  RQIKILEQENEHLNQTVSSLRQRSQISA--EARVKDIEKENKILHESIKETSSKLSKIEF 608

Query: 231  ENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRR----HLQFVEEEAE 286
            E R +K E+E  + + ER     +             LE   EL +    +L+   E+ E
Sbjct: 609  EKRQIKKELEHYKEKGERAEELENEL---------HHLEKENELLQKKITNLKITCEKIE 659

Query: 287  LLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQIS 346
             L +  SE+E  NR+L   L  F                             K+   Q+ 
Sbjct: 660  ALEQENSELERENRKLKKTLDSF-----------------------------KNLTFQLE 690

Query: 347  ELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQP 406
             L  +  +L  EN  L  N++    A+             A+     KE + E+ +L + 
Sbjct: 691  SLEKENSQLDEENLELRRNVESLKCASM----------KMAQLQLENKELESEKEQLKK- 739

Query: 407  KREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLER 466
                   G    +  F+KT                      R +  Y   L  E QRL++
Sbjct: 740  -------GLELLKASFKKTE---------------------RLEVSY-QGLDIENQRLQK 770

Query: 467  TVE---RLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFK 523
            T+E   + I   +S L D  +          LQ   E+ +   +  + L   N  ++   
Sbjct: 771  TLENSNKKIQQLESELQDLEMENQT------LQKNLEELKISSKRLEQLEKENKSLEQET 824

Query: 524  KELQAFLEQVNRIGDGLSPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQS--RLK 581
             +L+   +Q+ +    L     + +++   + V   + +     L KE+G   +S  RLK
Sbjct: 825  SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884

Query: 582  EQLEWQLGPARGDERESLRLRAARELHRRADGDTGSHGLGGQTCFSLELRGPPVLPEQSV 641
            E            E+E+      +EL +RA  D  +     +   S +L+   +  +   
Sbjct: 885  EL-----------EKEN------KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927

Query: 642  SIEELQGQLVQAARLHQEETETFTNKIHKMEEEHLYALRWKELEMHS---LALQNTLHER 698
               EL+   +   RL  +E  T  ++ +K+ E  L +   K LE+      AL+  L E 
Sbjct: 928  LTHELEKIGLNKERLLHDEQSTDDSR-YKLLESKLESTLKKSLEIKEEKIAALEARLEES 986

Query: 699  TWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLG 758
            T  +++  ++QEL+++K+N              +   KQ ++E                 
Sbjct: 987  TNYNQQ--LRQELKTVKKN--------------YEALKQRQDE----------------- 1013

Query: 759  ELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRG-QPHKQVVENQ 817
            E  VQ      G D+  +R       + +    +++ D  + ++  +   Q  KQ ++ Q
Sbjct: 1014 ERMVQSSPPISGEDNKWER-----ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ 1068

Query: 818  QLFSAFKALLEDFRAELREDERARLRLQQQ---YASDKAAWDVEWAVLKCRLEQLEEKTE 874
                  +    + +A++   +R  + LQ+Q     +  A   VE + L  +   L  +  
Sbjct: 1069 --LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNA 1126

Query: 875  NKLGELGSSAESKGALKKERE-----------VHQKL------LADSHSLVMDLRWQIHH 917
              L +  S      ++ KERE            H+KL       A  +  ++     +  
Sbjct: 1127 QLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKS 1186

Query: 918  SEKNWNREKVELLDRLDR-DRQEWERQKKEFLWRIEQ----LQKENSPRRGGSF--LCDQ 970
            + KN   E  +L DR ++  +Q+ + +  E + ++EQ    L+ +N       +  LC +
Sbjct: 1187 AHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGE 1246

Query: 971  KD 972
             D
Sbjct: 1247 ND 1248


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.130    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,144,331
Number of Sequences: 37866
Number of extensions: 3941636
Number of successful extensions: 21757
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 181
Number of HSP's successfully gapped in prelim test: 817
Number of HSP's that attempted gapping in prelim test: 15718
Number of HSP's gapped (non-prelim): 4845
length of query: 1586
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1470
effective length of database: 13,855,062
effective search space: 20366941140
effective search space used: 20366941140
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.