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Search of human proteins with 16306574
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16306574 F-box and leucine-rich repeat protein 5 isoform 2
[Homo sapiens]
(565 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16306574 F-box and leucine-rich repeat protein 5 isoform 2 [H... 1174 0.0
gi|16306572 F-box and leucine-rich repeat protein 5 isoform 1 [H... 1174 0.0
gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens] 57 3e-08
gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens] 57 5e-08
gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens] 50 4e-06
gi|15834621 F-box only protein 4 isoform 2 [Homo sapiens] 50 6e-06
gi|15834619 F-box only protein 4 isoform 1 [Homo sapiens] 50 6e-06
gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 ... 48 2e-05
gi|27312027 F-box only protein 16 [Homo sapiens] 47 4e-05
gi|30089926 F-box only protein 11 isoform 1 [Homo sapiens] 47 6e-05
gi|30089924 F-box only protein 11 isoform 2 [Homo sapiens] 47 6e-05
gi|30089922 F-box only protein 11 isoform 3 [Homo sapiens] 47 6e-05
gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1 ... 45 1e-04
gi|118150678 epithelial cell transforming sequence 2 oncogene-li... 42 0.001
gi|219281831 F-box protein 15 isoform 2 [Homo sapiens] 41 0.003
gi|22749363 F-box protein 15 isoform 1 [Homo sapiens] 41 0.003
gi|30795121 F-box and WD repeat domain containing 8 isoform 2 [H... 40 0.004
gi|30795123 F-box and WD repeat domain containing 8 isoform 1 [H... 40 0.004
gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens] 40 0.006
gi|8923179 F-box and leucine-rich repeat protein 12 [Homo sapiens] 39 0.010
gi|48928044 F-box only protein 8 [Homo sapiens] 38 0.022
gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens] 38 0.028
gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens] 38 0.028
gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo ... 37 0.048
gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo ... 37 0.048
gi|30520327 F-box protein 27 [Homo sapiens] 37 0.063
gi|190194416 F-box and leucine-rich repeat protein 15 [Homo sapi... 36 0.082
gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens] 36 0.082
gi|157168349 F-box and leucine-rich repeat protein 19 [Homo sapi... 36 0.11
gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [... 35 0.14
>gi|16306574 F-box and leucine-rich repeat protein 5 isoform 2 [Homo
sapiens]
Length = 565
Score = 1174 bits (3036), Expect = 0.0
Identities = 565/565 (100%), Positives = 565/565 (100%)
Query: 1 MKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNHAEERQKFFKY 60
MKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNHAEERQKFFKY
Sbjct: 1 MKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNHAEERQKFFKY 60
Query: 61 SVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWK 120
SVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWK
Sbjct: 61 SVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWK 120
Query: 121 HLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIA 180
HLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIA
Sbjct: 121 HLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIA 180
Query: 181 ISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQT 240
ISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQT
Sbjct: 181 ISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQT 240
Query: 241 DISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKI 300
DISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKI
Sbjct: 241 DISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKI 300
Query: 301 TSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAED 360
TSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAED
Sbjct: 301 TSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAED 360
Query: 361 LADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVCWQQHCASPAFAYC 420
LADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVCWQQHCASPAFAYC
Sbjct: 361 LADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVCWQQHCASPAFAYC 420
Query: 421 GHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLS 480
GHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLS
Sbjct: 421 GHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLS 480
Query: 481 GCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNIN 540
GCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNIN
Sbjct: 481 GCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNIN 540
Query: 541 GPHADTASGCQNLQCGFRACCRSGE 565
GPHADTASGCQNLQCGFRACCRSGE
Sbjct: 541 GPHADTASGCQNLQCGFRACCRSGE 565
>gi|16306572 F-box and leucine-rich repeat protein 5 isoform 1 [Homo
sapiens]
Length = 691
Score = 1174 bits (3036), Expect = 0.0
Identities = 565/565 (100%), Positives = 565/565 (100%)
Query: 1 MKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNHAEERQKFFKY 60
MKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNHAEERQKFFKY
Sbjct: 127 MKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNHAEERQKFFKY 186
Query: 61 SVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWK 120
SVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWK
Sbjct: 187 SVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWK 246
Query: 121 HLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIA 180
HLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIA
Sbjct: 247 HLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIA 306
Query: 181 ISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQT 240
ISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQT
Sbjct: 307 ISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQT 366
Query: 241 DISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKI 300
DISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKI
Sbjct: 367 DISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKI 426
Query: 301 TSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAED 360
TSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAED
Sbjct: 427 TSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAED 486
Query: 361 LADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVCWQQHCASPAFAYC 420
LADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVCWQQHCASPAFAYC
Sbjct: 487 LADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVCWQQHCASPAFAYC 546
Query: 421 GHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLS 480
GHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLS
Sbjct: 547 GHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLS 606
Query: 481 GCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNIN 540
GCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNIN
Sbjct: 607 GCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNIN 666
Query: 541 GPHADTASGCQNLQCGFRACCRSGE 565
GPHADTASGCQNLQCGFRACCRSGE
Sbjct: 667 GPHADTASGCQNLQCGFRACCRSGE 691
>gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens]
Length = 423
Score = 57.4 bits (137), Expect = 3e-08
Identities = 52/199 (26%), Positives = 80/199 (40%), Gaps = 62/199 (31%)
Query: 82 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPATELD 141
LP E++L IFS+L+ LCRC+Q+S W+ L GS +W R D ++ ++D
Sbjct: 15 LPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGS--------NWQRIDLFN---FQID 63
Query: 142 TEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPY 201
E ++ N+
Sbjct: 64 VEGR------------------------------------------------VVENISKR 75
Query: 202 VGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQ-TDISDSAFDSWSWLGCCQSLR 260
G ++ L L V ++ + C N+EHL+L T I+DS S S C L+
Sbjct: 76 CGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRF--CSKLK 133
Query: 261 HLDLSGCEKITDVALEKIS 279
HLDL+ C IT+ +L+ IS
Sbjct: 134 HLDLTSCVSITNSSLKGIS 152
Score = 41.2 bits (95), Expect = 0.003
Identities = 27/93 (29%), Positives = 47/93 (50%), Gaps = 3/93 (3%)
Query: 463 SEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLV 522
S K+ + R + L+L+GC +ITD +L L+HL+L+ C++IT + L+ +
Sbjct: 95 SLKTFAQNCRNIEHLNLNGCTKITDS--TCYSLSRFCSKLKHLDLTSCVSITNSSLKGIS 152
Query: 523 SACPSLNDEYFYYCDNINGPHADT-ASGCQNLQ 554
C +L +CD I + GC+ L+
Sbjct: 153 EGCRNLEYLNLSWCDQITKDGIEALVRGCRGLK 185
Score = 36.6 bits (83), Expect = 0.063
Identities = 23/55 (41%), Positives = 30/55 (54%), Gaps = 2/55 (3%)
Query: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSL 528
L+ L+L C +ITD G V+ + G L+ L LSGC +T A L L CP L
Sbjct: 210 LVSLNLQSCSRITDEG--VVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRL 262
Score = 32.3 bits (72), Expect = 1.2
Identities = 22/58 (37%), Positives = 30/58 (51%), Gaps = 2/58 (3%)
Query: 229 CPNLEHLDLTQTD-ISDSAFDSWSWLGCC-QSLRHLDLSGCEKITDVALEKISRALGI 284
CP L+ L L+ + I+D S C + LR L+L C ITDVALE + G+
Sbjct: 311 CPKLQALSLSHCELITDDGILHLSNSTCGHERLRVLELDNCLLITDVALEHLENCRGL 368
Score = 32.0 bits (71), Expect = 1.6
Identities = 12/25 (48%), Positives = 18/25 (72%)
Query: 256 CQSLRHLDLSGCEKITDVALEKISR 280
C+++ HL+L+GC KITD +SR
Sbjct: 103 CRNIEHLNLNGCTKITDSTCYSLSR 127
Score = 30.4 bits (67), Expect = 4.5
Identities = 24/83 (28%), Positives = 33/83 (39%), Gaps = 5/83 (6%)
Query: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
L L + C +TD G +L LE ++L C+ IT + L L CP L
Sbjct: 262 LQILEAARCSHLTDAGFTLLARN--CHELEKMDLEECILITDSTLIQLSIHCPKLQALSL 319
Query: 534 YYCDNINGPHADTASGCQNLQCG 556
+C+ I D N CG
Sbjct: 320 SHCELITD---DGILHLSNSTCG 339
Score = 30.0 bits (66), Expect = 5.9
Identities = 37/125 (29%), Positives = 43/125 (34%), Gaps = 27/125 (21%)
Query: 463 SEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLG---------GGLPYLEH--------- 504
S K E R L +L+LS C QIT G+ L G G LE
Sbjct: 147 SLKGISEGCRNLEYLNLSWCDQITKDGIEALVRGCRGLKALLLRGCTQLEDEALKHIQNY 206
Query: 505 ------LNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINGPHADTASG--CQNLQCG 556
LNL C IT G+ + C L C N+ TA G C LQ
Sbjct: 207 CHELVSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCSNLTDASL-TALGLNCPRLQIL 265
Query: 557 FRACC 561
A C
Sbjct: 266 EAARC 270
>gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens]
Length = 436
Score = 57.0 bits (136), Expect = 5e-08
Identities = 53/205 (25%), Positives = 80/205 (39%), Gaps = 62/205 (30%)
Query: 82 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPATELD 141
LP E++L IFS+L+ LCRC+QVS W+ L GS +W R D +
Sbjct: 28 LPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGS--------NWQRIDLF-------- 71
Query: 142 TEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPY 201
D DI+ ++ N+
Sbjct: 72 ---------------------DFQRDIEGR----------------------VVENISKR 88
Query: 202 VGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQ-TDISDSAFDSWSWLGCCQSLR 260
G ++ L L V +R + C N+E L+L T +D+ S S C LR
Sbjct: 89 CGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKF--CSKLR 146
Query: 261 HLDLSGCEKITDVALEKISRALGIL 285
HLDL+ C IT+++L+ +S +L
Sbjct: 147 HLDLASCTSITNMSLKALSEGCPLL 171
Score = 41.2 bits (95), Expect = 0.003
Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 2/66 (3%)
Query: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
L L L+ C IT+ L+ L+ G P LE LN+S C +T G+Q LV C L +
Sbjct: 145 LRHLDLASCTSITNMSLKALS--EGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFL 202
Query: 534 YYCDNI 539
C +
Sbjct: 203 KGCTQL 208
Score = 39.7 bits (91), Expect = 0.007
Identities = 30/82 (36%), Positives = 37/82 (45%), Gaps = 3/82 (3%)
Query: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
L+ L+L C QITD GL +T+ G L+ L SGC IT A L L CP L
Sbjct: 223 LVTLNLQTCLQITDEGL--ITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEV 280
Query: 534 YYCDNINGPHADT-ASGCQNLQ 554
C + T A C L+
Sbjct: 281 ARCSQLTDVGFTTLARNCHELE 302
Score = 38.5 bits (88), Expect = 0.017
Identities = 24/63 (38%), Positives = 28/63 (44%), Gaps = 2/63 (3%)
Query: 477 LSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYC 536
L L GC Q+ D L+ + G P L LNL CL IT GL + C L C
Sbjct: 200 LFLKGCTQLEDEALKYI--GAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGC 257
Query: 537 DNI 539
NI
Sbjct: 258 SNI 260
Score = 37.4 bits (85), Expect = 0.037
Identities = 29/67 (43%), Positives = 32/67 (47%), Gaps = 2/67 (2%)
Query: 474 LLFLSLSGCYQITDHGLRVLTLGG-GLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEY 532
L LSLS C ITD G+R L G LE + L C IT A L+ L S C SL
Sbjct: 327 LQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKS-CHSLERIE 385
Query: 533 FYYCDNI 539
Y C I
Sbjct: 386 LYDCQQI 392
Score = 36.2 bits (82), Expect = 0.082
Identities = 29/92 (31%), Positives = 36/92 (39%), Gaps = 3/92 (3%)
Query: 464 EKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVS 523
E + G L LSL GC + D+ LR T +E LNL+GC T A L
Sbjct: 83 ENISKRCGGFLRKLSLRGCLGVGDNALR--TFAQNCRNIEVLNLNGCTKTTDATCTSLSK 140
Query: 524 ACPSLNDEYFYYCDNINGPHADTAS-GCQNLQ 554
C L C +I S GC L+
Sbjct: 141 FCSKLRHLDLASCTSITNMSLKALSEGCPLLE 172
Score = 32.7 bits (73), Expect = 0.91
Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 2/66 (3%)
Query: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
L L ++ C Q+TD G TL LE ++L C+ IT + L L CP L
Sbjct: 275 LRILEVARCSQLTDVGFT--TLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSL 332
Query: 534 YYCDNI 539
+C+ I
Sbjct: 333 SHCELI 338
>gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]
Length = 491
Score = 50.4 bits (119), Expect = 4e-06
Identities = 92/453 (20%), Positives = 157/453 (34%), Gaps = 109/453 (24%)
Query: 74 EHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWY 133
+ I LP M+ IFS+L +LCRC++V +W Y + W W
Sbjct: 109 KEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRW-------------YNLAWDPRLW- 154
Query: 134 SGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHG 193
R E ++D + + + +RL
Sbjct: 155 -----------------------RTIRLTGETINVDRA-----------LKVLTRRLCQD 180
Query: 194 LIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQT-DISDSAFDSWSW 252
P V ++T+ ++ ++ + + I + CP L L+++ +IS+ A +
Sbjct: 181 T-----PNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAV--FDV 233
Query: 253 LGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITM 312
+ C +L HLD+SGC K+T ++L T + I + K I++
Sbjct: 234 VSLCPNLEHLDVSGCSKVTCISL-------------------TREASIKLSPLHGKQISI 274
Query: 313 QSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRH 372
+ C +++E T T Y + V
Sbjct: 275 RYLDMTDCF----------VLEDEGLHTIAAHCTQLTHLY-----------LRRCVRLTD 313
Query: 373 RNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALR 432
+ L V+ AS S S C GLR + + A+CG T +R
Sbjct: 314 EGLRYL-VIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGR---VTDVGIR 369
Query: 433 TMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRV 492
++ C K + + G E + + L L + C ++D GL
Sbjct: 370 YVAK------YCSKLRYLNARGCEGITDHGVEYLAKNCTK-LKSLDIGKCPLVSDTGLEC 422
Query: 493 LTLGGGLPYLEHLNLSGCLTITGAGLQDLVSAC 525
L L L+ L+L C +ITG GLQ + + C
Sbjct: 423 LAL--NCFNLKRLSLKSCESITGQGLQIVAANC 453
Score = 47.4 bits (111), Expect = 4e-05
Identities = 32/91 (35%), Positives = 44/91 (48%), Gaps = 19/91 (20%)
Query: 468 QETGRVLLFL---SLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSA 524
Q+T V L L ++SGC ++TD GL T+ P L L +SGC I+ + D+VS
Sbjct: 179 QDTPNVCLMLETVTVSGCRRLTDRGL--YTIAQCCPELRRLEVSGCYNISNEAVFDVVSL 236
Query: 525 CPSLNDEYFYYCDNINGPHADTASGCQNLQC 555
CP+L H D SGC + C
Sbjct: 237 CPNLE-------------HLD-VSGCSKVTC 253
Score = 37.4 bits (85), Expect = 0.037
Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 3/82 (3%)
Query: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
L +L+ GC ITDHG+ L L+ L++ C ++ GL+ L C +L
Sbjct: 378 LRYLNARGCEGITDHGVEY--LAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSL 435
Query: 534 YYCDNINGPHAD-TASGCQNLQ 554
C++I G A+ C +LQ
Sbjct: 436 KSCESITGQGLQIVAANCFDLQ 457
Score = 35.8 bits (81), Expect = 0.11
Identities = 18/55 (32%), Positives = 29/55 (52%), Gaps = 2/55 (3%)
Query: 476 FLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLND 530
+L ++ C+ + D GL T+ L HL L C+ +T GL+ LV C S+ +
Sbjct: 276 YLDMTDCFVLEDEGLH--TIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKE 328
Score = 35.8 bits (81), Expect = 0.11
Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 6/82 (7%)
Query: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
L +LS++ C ++TD G+R + L +LN GC IT G++ L C L
Sbjct: 352 LRYLSIAHCGRVTDVGIRY--VAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDI 409
Query: 534 YYCDNINGPHADTASGCQNLQC 555
C + +DT C L C
Sbjct: 410 GKCPLV----SDTGLECLALNC 427
>gi|15834621 F-box only protein 4 isoform 2 [Homo sapiens]
Length = 307
Score = 50.1 bits (118), Expect = 6e-06
Identities = 25/86 (29%), Positives = 44/86 (51%), Gaps = 3/86 (3%)
Query: 65 KSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLY- 123
++ EV E ++ +T LP +V L I S+L+P +LC+ + W++ + LW++
Sbjct: 45 RTTSREEVDEAASTLTRLPIDVQLYILSFLSPHDLCQLGSTNHYWNETVRDPILWRYFLL 104
Query: 124 --PVHWARGDWYSGPATELDTEPDDE 147
W+ DW S P E+ +P E
Sbjct: 105 RDLPSWSSVDWKSLPDLEILKKPISE 130
>gi|15834619 F-box only protein 4 isoform 1 [Homo sapiens]
Length = 387
Score = 50.1 bits (118), Expect = 6e-06
Identities = 25/86 (29%), Positives = 44/86 (51%), Gaps = 3/86 (3%)
Query: 65 KSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLY- 123
++ EV E ++ +T LP +V L I S+L+P +LC+ + W++ + LW++
Sbjct: 45 RTTSREEVDEAASTLTRLPIDVQLYILSFLSPHDLCQLGSTNHYWNETVRDPILWRYFLL 104
Query: 124 --PVHWARGDWYSGPATELDTEPDDE 147
W+ DW S P E+ +P E
Sbjct: 105 RDLPSWSSVDWKSLPDLEILKKPISE 130
>gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2
[Homo sapiens]
Length = 690
Score = 48.1 bits (113), Expect = 2e-05
Identities = 121/565 (21%), Positives = 211/565 (37%), Gaps = 73/565 (12%)
Query: 30 AQHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEH--------STGITH 81
A+H S+K EL+ L + + K + E+S+ S I+
Sbjct: 98 ARHKSKKKEDELILKHELQLKKWKNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISL 157
Query: 82 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLW--------KHLYPVHWARGDWY 133
LP +L IF YL+ +++ C QV+ W +T+ SLW K++ P +
Sbjct: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQ 217
Query: 134 SGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESI--------AISIAQ 185
L ++ + S + ++ ++ + +ES+ +
Sbjct: 218 RWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLN 277
Query: 186 MEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILEL---CPNLEHLDLTQ-TD 241
+ + +LP +++ L LAY + K + Q L L C L +LDL+ T
Sbjct: 278 LSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGL-QYLNLGNGCHKLIYLDLSGCTQ 336
Query: 242 ISDSAFDSWSWLGCCQSLRHLDLSGCEKITD----VALEKISRALGIL---TSHQSG--F 292
IS F + C + HL ++ +TD +EK SR ++ H S F
Sbjct: 337 ISVQGFRYIA--NSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTF 394
Query: 293 LKTSTSKITSTAWK-NKDITMQSTK-------QYACLHDLTNKGIGEEIDNEHPWTKPVS 344
S K+ ++ NK +T S K + ++ KGI + K ++
Sbjct: 395 RALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLT 454
Query: 345 SENFTS-PYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLR 403
N + + + + D ++ R N+ S CV + ++ + C + + + LR
Sbjct: 455 VLNLANCVRIGDMGLKQFLDGPASMRIRELNL-SNCVRLSDASVMKLSERCPNLNYLSLR 513
Query: 404 TSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGS 463
+H + Y + F ++ S+ S L R K L
Sbjct: 514 NC----EHLTAQGIGYIVNIF--------SLVSIDLSGTDISNEGLNVLSRHKKL----K 557
Query: 464 EKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVS 523
E S E R+ QITD + +L+ YL L++SGC+ +T L+DL
Sbjct: 558 ELSVSECYRI-----TDDGIQITDSAMEMLS--AKCHYLHILDISGCVLLTDQILEDLQI 610
Query: 524 ACPSLNDEYFYYCDNINGPHADTAS 548
C L YC NI+ A S
Sbjct: 611 GCKQLRILKMQYCTNISKKAAQRMS 635
Score = 32.3 bits (72), Expect = 1.2
Identities = 21/78 (26%), Positives = 35/78 (44%), Gaps = 2/78 (2%)
Query: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
L++L LSGC QI+ G R + + HL ++ T+T ++ LV C + F
Sbjct: 326 LIYLDLSGCTQISVQGFRY--IANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVF 383
Query: 534 YYCDNINGPHADTASGCQ 551
+I+ S C+
Sbjct: 384 TGAPHISDCTFRALSACK 401
>gi|27312027 F-box only protein 16 [Homo sapiens]
Length = 292
Score = 47.4 bits (111), Expect = 4e-05
Identities = 29/80 (36%), Positives = 39/80 (48%), Gaps = 9/80 (11%)
Query: 54 RQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLT 113
+QKF + EK EA T LP + L IFS+L+P+ LCRC+QV W L
Sbjct: 69 QQKFCCRKLQEKIPAEA-----LDFTTKLPRVLSLYIFSFLDPRSLCRCAQVCWHWKNLA 123
Query: 114 KTGSLWKHLYPVHWARGDWY 133
+ LW + R +WY
Sbjct: 124 ELDQLWM----LKCLRFNWY 139
>gi|30089926 F-box only protein 11 isoform 1 [Homo sapiens]
Length = 843
Score = 46.6 bits (109), Expect = 6e-05
Identities = 22/42 (52%), Positives = 28/42 (66%)
Query: 82 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLY 123
LP EV+L IFSYL Q+LCR + V ++S+L LWK LY
Sbjct: 75 LPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLY 116
>gi|30089924 F-box only protein 11 isoform 2 [Homo sapiens]
Length = 686
Score = 46.6 bits (109), Expect = 6e-05
Identities = 22/42 (52%), Positives = 28/42 (66%)
Query: 82 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLY 123
LP EV+L IFSYL Q+LCR + V ++S+L LWK LY
Sbjct: 75 LPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLY 116
>gi|30089922 F-box only protein 11 isoform 3 [Homo sapiens]
Length = 585
Score = 46.6 bits (109), Expect = 6e-05
Identities = 22/42 (52%), Positives = 28/42 (66%)
Query: 82 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLY 123
LP EV+L IFSYL Q+LCR + V ++S+L LWK LY
Sbjct: 75 LPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLY 116
>gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1
[Homo sapiens]
Length = 735
Score = 45.4 bits (106), Expect = 1e-04
Identities = 27/75 (36%), Positives = 39/75 (52%), Gaps = 2/75 (2%)
Query: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
L LS++GC +ITD + +L+ YL L++SGC+ +T L+DL C L
Sbjct: 608 LTSLSIAGCPKITDSAMEMLS--AKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKM 665
Query: 534 YYCDNINGPHADTAS 548
YC NI+ A S
Sbjct: 666 QYCTNISKKAAQRMS 680
Score = 43.5 bits (101), Expect = 5e-04
Identities = 21/52 (40%), Positives = 32/52 (61%)
Query: 477 LSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSL 528
LSL+ C + TD GL+ L LG G L +L+LSGC I+ G + + ++C +
Sbjct: 301 LSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGI 352
Score = 41.2 bits (95), Expect = 0.003
Identities = 21/66 (31%), Positives = 34/66 (51%)
Query: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
L L+L+ C +I D GL+ G + LNLS C+ ++ A + L CP+LN
Sbjct: 453 LTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSL 512
Query: 534 YYCDNI 539
C+++
Sbjct: 513 RNCEHL 518
Score = 38.1 bits (87), Expect = 0.022
Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 8/98 (8%)
Query: 30 AQHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEH--------STGITH 81
A+H S+K EL+ L + + K + E+S+ S I+
Sbjct: 98 ARHKSKKKEDELILKHELQLKKWKNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISL 157
Query: 82 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLW 119
LP +L IF YL+ +++ C QV+ W +T+ SLW
Sbjct: 158 LPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLW 195
Score = 36.6 bits (83), Expect = 0.063
Identities = 24/71 (33%), Positives = 37/71 (52%), Gaps = 3/71 (4%)
Query: 209 LVLAYSSAVSSKMVRQILELCPNLEHLDLTQTD-ISDSAFDSWSWLGCCQSLRHLDLSGC 267
L ++Y S +S +++ + C NL L + I+DSA + S C L LD+SGC
Sbjct: 585 LDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLS--AKCHYLHILDISGC 642
Query: 268 EKITDVALEKI 278
+TD LE +
Sbjct: 643 VLLTDQILEDL 653
Score = 35.8 bits (81), Expect = 0.11
Identities = 35/135 (25%), Positives = 57/135 (42%), Gaps = 13/135 (9%)
Query: 392 SGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTR 451
+GC ++ L S C Q + F Y +S CTG T++ +P + C KA +
Sbjct: 321 NGCHK--LIYLDLSGCTQ--ISVQGFRYIANS--CTGIMHLTINDMPTLTDNCVKALVEK 374
Query: 452 LPRGKDLIYFGSEKSDQETGRVLLFLSL-----SGCYQITDHGLRVLTLGGGLPYLEHLN 506
R L++ G+ T R L L G ++TD + + P L H+
Sbjct: 375 CSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKF--IDKNYPNLSHIY 432
Query: 507 LSGCLTITGAGLQDL 521
++ C IT + L+ L
Sbjct: 433 MADCKGITDSSLRSL 447
Score = 33.5 bits (75), Expect = 0.53
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 6/81 (7%)
Query: 477 LSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYC 536
LS+S CY+ITD G++ + LEHL++S C ++ ++ L C +L C
Sbjct: 559 LSVSECYRITDDGIQAFCKSSLI--LEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGC 616
Query: 537 DNINGPHADTASGCQNLQCGF 557
I D+A + +C +
Sbjct: 617 PKI----TDSAMEMLSAKCHY 633
Score = 32.7 bits (73), Expect = 0.91
Identities = 19/49 (38%), Positives = 30/49 (61%), Gaps = 3/49 (6%)
Query: 232 LEHLDLTQ-TDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKIS 279
LEHLD++ + +SD + + C +L L ++GC KITD A+E +S
Sbjct: 582 LEHLDVSYCSQLSDMIIKALAIY--CINLTSLSIAGCPKITDSAMEMLS 628
Score = 32.3 bits (72), Expect = 1.2
Identities = 21/78 (26%), Positives = 35/78 (44%), Gaps = 2/78 (2%)
Query: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
L++L LSGC QI+ G R + + HL ++ T+T ++ LV C + F
Sbjct: 326 LIYLDLSGCTQISVQGFRY--IANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVF 383
Query: 534 YYCDNINGPHADTASGCQ 551
+I+ S C+
Sbjct: 384 TGAPHISDCTFRALSACK 401
>gi|118150678 epithelial cell transforming sequence 2 oncogene-like
[Homo sapiens]
Length = 904
Score = 42.4 bits (98), Expect = 0.001
Identities = 19/40 (47%), Positives = 26/40 (65%)
Query: 80 THLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLW 119
T LP + L IFS+L+P++LC +QVS W LT+ LW
Sbjct: 79 TVLPRFISLYIFSFLSPKDLCAAAQVSWPWKFLTEQDCLW 118
>gi|219281831 F-box protein 15 isoform 2 [Homo sapiens]
Length = 510
Score = 41.2 bits (95), Expect = 0.003
Identities = 49/197 (24%), Positives = 79/197 (40%), Gaps = 39/197 (19%)
Query: 82 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHW--ARGDWYSGPATE 139
+P E++L IFSYL+ L VS ++ L +W +Y + AR +W +
Sbjct: 77 MPSEILLKIFSYLDAVSLLCTGCVSRRFYHLANDNFIWIGIYSTAFSPARSNWKFNSVEK 136
Query: 140 LDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVL 199
+ V+++ E+ +E I IA + K L ++ V
Sbjct: 137 IAMSMSFLSVQDK-----------------EAGYWKKEYITKQIASV-KAALADILKPVN 178
Query: 200 PYVGTSVKT------LVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWL 253
PY G VKT L ++ + K ++ + +EH+DL+ D S + W
Sbjct: 179 PYTGLPVKTKEALRIFGLGWAIILKEKGGKEYI-----MEHVDLSINDTSVTVI----WY 229
Query: 254 G----CCQSLRHLDLSG 266
G C SL LDL G
Sbjct: 230 GKKWPCLASLSTLDLCG 246
>gi|22749363 F-box protein 15 isoform 1 [Homo sapiens]
Length = 434
Score = 41.2 bits (95), Expect = 0.003
Identities = 49/197 (24%), Positives = 79/197 (40%), Gaps = 39/197 (19%)
Query: 82 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHW--ARGDWYSGPATE 139
+P E++L IFSYL+ L VS ++ L +W +Y + AR +W +
Sbjct: 1 MPSEILLKIFSYLDAVSLLCTGCVSRRFYHLANDNFIWIGIYSTAFSPARSNWKFNSVEK 60
Query: 140 LDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVL 199
+ V+++ E+ +E I IA + K L ++ V
Sbjct: 61 IAMSMSFLSVQDK-----------------EAGYWKKEYITKQIASV-KAALADILKPVN 102
Query: 200 PYVGTSVKT------LVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWL 253
PY G VKT L ++ + K ++ + +EH+DL+ D S + W
Sbjct: 103 PYTGLPVKTKEALRIFGLGWAIILKEKGGKEYI-----MEHVDLSINDTSVTVI----WY 153
Query: 254 G----CCQSLRHLDLSG 266
G C SL LDL G
Sbjct: 154 GKKWPCLASLSTLDLCG 170
>gi|30795121 F-box and WD repeat domain containing 8 isoform 2 [Homo
sapiens]
Length = 532
Score = 40.4 bits (93), Expect = 0.004
Identities = 18/41 (43%), Positives = 26/41 (63%)
Query: 82 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHL 122
LP E+ ++IF YL+ +EL RC+QVS W + + LW L
Sbjct: 53 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 93
>gi|30795123 F-box and WD repeat domain containing 8 isoform 1 [Homo
sapiens]
Length = 598
Score = 40.4 bits (93), Expect = 0.004
Identities = 18/41 (43%), Positives = 26/41 (63%)
Query: 82 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHL 122
LP E+ ++IF YL+ +EL RC+QVS W + + LW L
Sbjct: 119 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 159
>gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens]
Length = 621
Score = 40.0 bits (92), Expect = 0.006
Identities = 32/104 (30%), Positives = 50/104 (48%), Gaps = 5/104 (4%)
Query: 205 SVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGC-CQSLRHLD 263
S+K LVL Y + V + IL C L+HL L + + S +G C+ LR LD
Sbjct: 427 SLKRLVL-YRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLD 485
Query: 264 LSGCEKITDVALEKISRALGILTSHQSGF---LKTSTSKITSTA 304
L C+ IT+ + +++ +L G+ L++ST T A
Sbjct: 486 LWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLA 529
Score = 32.3 bits (72), Expect = 1.2
Identities = 26/97 (26%), Positives = 39/97 (40%), Gaps = 23/97 (23%)
Query: 199 LPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTD-ISDSAFDS-------- 249
L G+ + L L+ S ++ + I E+CPNL+ L+L+ D + AF+
Sbjct: 370 LKVCGSELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLK 429
Query: 250 --------------WSWLGCCQSLRHLDLSGCEKITD 272
S L C L+HL L C I D
Sbjct: 430 RLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIED 466
>gi|8923179 F-box and leucine-rich repeat protein 12 [Homo sapiens]
Length = 326
Score = 39.3 bits (90), Expect = 0.010
Identities = 17/44 (38%), Positives = 26/44 (59%)
Query: 79 ITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHL 122
+ LP V+L IFSYL ++ R S+V +W +L LW+H+
Sbjct: 4 LVELPDSVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHV 47
>gi|48928044 F-box only protein 8 [Homo sapiens]
Length = 319
Score = 38.1 bits (87), Expect = 0.022
Identities = 21/67 (31%), Positives = 31/67 (46%), Gaps = 3/67 (4%)
Query: 68 KEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHW 127
++++ E + LPPE+ +I SYLN +LC S V W L LW+ L W
Sbjct: 60 RKSKEQEGFINLEMLPPELSFTILSYLNATDLCLASCV---WQDLANDELLWQGLCKSTW 116
Query: 128 ARGDWYS 134
Y+
Sbjct: 117 GHCSIYN 123
>gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens]
Length = 223
Score = 37.7 bits (86), Expect = 0.028
Identities = 35/139 (25%), Positives = 64/139 (46%), Gaps = 11/139 (7%)
Query: 164 EDADIDESEESAEESIA-----ISIAQMEKRLLHGLIHNVLPYVGT---SVKTLVLAYSS 215
++ D+ + + S+A + + Q+ LL L N L V S++ L L++ S
Sbjct: 78 QELDLTACSKLTDASLAKVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSHCS 137
Query: 216 AVSSKMVRQILELCPNLEHLDLTQ-TDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVA 274
+S K Q P L+HL+L+ + + + D+ C+ LR LD++ C I A
Sbjct: 138 RLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIG--QACRQLRVLDVATCPGINMAA 195
Query: 275 LEKISRALGILTSHQSGFL 293
+ + L ++ QS F+
Sbjct: 196 VRRFQAQLPQVSCVQSRFV 214
Score = 37.7 bits (86), Expect = 0.028
Identities = 32/105 (30%), Positives = 46/105 (43%), Gaps = 8/105 (7%)
Query: 463 SEKSDQETGRVLLFL-----SLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAG 517
S+ +D +VL FL SLS ++TD+GL + + G P LEHL LS C ++ G
Sbjct: 86 SKLTDASLAKVLQFLQLRQLSLSLLPELTDNGL--VAVARGCPSLEHLALSHCSRLSDKG 143
Query: 518 LQDLVSACPSLNDEYFYYCDNINGPHADT-ASGCQNLQCGFRACC 561
S+ P L C + D C+ L+ A C
Sbjct: 144 WAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATC 188
Score = 32.3 bits (72), Expect = 1.2
Identities = 21/64 (32%), Positives = 28/64 (43%), Gaps = 2/64 (3%)
Query: 477 LSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYC 536
L+LS C +++D G P L+HLNLS C + L + AC L C
Sbjct: 131 LALSHCSRLSDKGWA--QAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATC 188
Query: 537 DNIN 540
IN
Sbjct: 189 PGIN 192
>gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens]
Length = 223
Score = 37.7 bits (86), Expect = 0.028
Identities = 35/139 (25%), Positives = 64/139 (46%), Gaps = 11/139 (7%)
Query: 164 EDADIDESEESAEESIA-----ISIAQMEKRLLHGLIHNVLPYVGT---SVKTLVLAYSS 215
++ D+ + + S+A + + Q+ LL L N L V S++ L L++ S
Sbjct: 78 QELDLTACSKLTDASLAKVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSHCS 137
Query: 216 AVSSKMVRQILELCPNLEHLDLTQ-TDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVA 274
+S K Q P L+HL+L+ + + + D+ C+ LR LD++ C I A
Sbjct: 138 RLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIG--QACRQLRVLDVATCPGINMAA 195
Query: 275 LEKISRALGILTSHQSGFL 293
+ + L ++ QS F+
Sbjct: 196 VRRFQAQLPQVSCVQSRFV 214
Score = 37.7 bits (86), Expect = 0.028
Identities = 32/105 (30%), Positives = 46/105 (43%), Gaps = 8/105 (7%)
Query: 463 SEKSDQETGRVLLFL-----SLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAG 517
S+ +D +VL FL SLS ++TD+GL + + G P LEHL LS C ++ G
Sbjct: 86 SKLTDASLAKVLQFLQLRQLSLSLLPELTDNGL--VAVARGCPSLEHLALSHCSRLSDKG 143
Query: 518 LQDLVSACPSLNDEYFYYCDNINGPHADT-ASGCQNLQCGFRACC 561
S+ P L C + D C+ L+ A C
Sbjct: 144 WAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATC 188
Score = 32.3 bits (72), Expect = 1.2
Identities = 21/64 (32%), Positives = 28/64 (43%), Gaps = 2/64 (3%)
Query: 477 LSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYC 536
L+LS C +++D G P L+HLNLS C + L + AC L C
Sbjct: 131 LALSHCSRLSDKGWA--QAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATC 188
Query: 537 DNIN 540
IN
Sbjct: 189 PGIN 192
>gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo
sapiens]
Length = 424
Score = 37.0 bits (84), Expect = 0.048
Identities = 56/232 (24%), Positives = 87/232 (37%), Gaps = 37/232 (15%)
Query: 82 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPATELD 141
LP E++L IFS L EL + S V +W +L SLW+ L T +
Sbjct: 100 LPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTL-------------DLTGKN 146
Query: 142 TEPD--DEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVL 199
PD + R + + + + + +S + +E LHG++
Sbjct: 147 LHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGILSQCS 206
Query: 200 PYVGTSVKTLVLA----YSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGC 255
S++ L L+ + A +S +VR L C S F + L
Sbjct: 207 KLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGF------------SEFALQTLLSS 254
Query: 256 CQSLRHLDLSGC----EKITDVALEKISRALGILTSHQSGFLKTSTSKITST 303
C L L+LS C EK VA+ +S + L + SG+ K ST
Sbjct: 255 CSRLDELNLSWCFDFTEKHVQVAVAHVSETITQL--NLSGYRKNLQKSDLST 304
Score = 32.0 bits (71), Expect = 1.6
Identities = 16/46 (34%), Positives = 23/46 (50%)
Query: 502 LEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINGPHADTA 547
L LNLSGC + LQ L+S+C L++ +C + H A
Sbjct: 232 LVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVA 277
Score = 31.2 bits (69), Expect = 2.6
Identities = 26/106 (24%), Positives = 46/106 (43%), Gaps = 5/106 (4%)
Query: 201 YVGTSVKTLVLA-YSSAVSSKMVRQILELCPNLEHLDLTQT-DISDSAFDSWSWLGCCQS 258
+V ++ L L+ Y + + ++ CPNL HLDL+ + + + F + L
Sbjct: 280 HVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQL---NY 336
Query: 259 LRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKITSTA 304
L+HL LS C I L ++ + T G + T ++ A
Sbjct: 337 LQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDGTLQLLKEA 382
>gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo
sapiens]
Length = 410
Score = 37.0 bits (84), Expect = 0.048
Identities = 56/232 (24%), Positives = 87/232 (37%), Gaps = 37/232 (15%)
Query: 82 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPATELD 141
LP E++L IFS L EL + S V +W +L SLW+ L T +
Sbjct: 100 LPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTL-------------DLTGKN 146
Query: 142 TEPD--DEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVL 199
PD + R + + + + + +S + +E LHG++
Sbjct: 147 LHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGILSQCS 206
Query: 200 PYVGTSVKTLVLA----YSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGC 255
S++ L L+ + A +S +VR L C S F + L
Sbjct: 207 KLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGF------------SEFALQTLLSS 254
Query: 256 CQSLRHLDLSGC----EKITDVALEKISRALGILTSHQSGFLKTSTSKITST 303
C L L+LS C EK VA+ +S + L + SG+ K ST
Sbjct: 255 CSRLDELNLSWCFDFTEKHVQVAVAHVSETITQL--NLSGYRKNLQKSDLST 304
Score = 32.0 bits (71), Expect = 1.6
Identities = 16/46 (34%), Positives = 23/46 (50%)
Query: 502 LEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINGPHADTA 547
L LNLSGC + LQ L+S+C L++ +C + H A
Sbjct: 232 LVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVA 277
Score = 32.0 bits (71), Expect = 1.6
Identities = 24/83 (28%), Positives = 40/83 (48%), Gaps = 5/83 (6%)
Query: 201 YVGTSVKTLVLA-YSSAVSSKMVRQILELCPNLEHLDLTQT-DISDSAFDSWSWLGCCQS 258
+V ++ L L+ Y + + ++ CPNL HLDL+ + + + F + L
Sbjct: 280 HVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQL---NY 336
Query: 259 LRHLDLSGCEKITDVALEKISRA 281
L+HL LS C I L ++RA
Sbjct: 337 LQHLSLSRCYDIIPETLLLVTRA 359
>gi|30520327 F-box protein 27 [Homo sapiens]
Length = 283
Score = 36.6 bits (83), Expect = 0.063
Identities = 17/47 (36%), Positives = 27/47 (57%), Gaps = 1/47 (2%)
Query: 74 EHSTGITHLPPEVMLSIFSYLNPQELC-RCSQVSMKWSQLTKTGSLW 119
E + ++ LPPE++L + S++ P+ L RC QV W L +LW
Sbjct: 21 EEALDLSQLPPELLLVVLSHVPPRTLLGRCRQVCRGWRALVDGQALW 67
>gi|190194416 F-box and leucine-rich repeat protein 15 [Homo
sapiens]
Length = 300
Score = 36.2 bits (82), Expect = 0.082
Identities = 22/72 (30%), Positives = 34/72 (47%), Gaps = 2/72 (2%)
Query: 468 QETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPS 527
Q G L LSL+ + D ++ L P L HL+L+GCL + G++ L CP
Sbjct: 189 QRRGAGLRSLSLAVNANVGDAAVQ--ELARNCPELHHLDLTGCLRVGSDGVRTLAEYCPV 246
Query: 528 LNDEYFYYCDNI 539
L +C ++
Sbjct: 247 LRSLRVRHCHHV 258
Score = 35.0 bits (79), Expect = 0.18
Identities = 36/159 (22%), Positives = 59/159 (37%), Gaps = 38/159 (23%)
Query: 160 HEWDEDADIDE--SEESAEESIAIS-IAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSA 216
HEW D D+ + S+A+ Q+ +R L L ++ L LA+
Sbjct: 98 HEWLSDEDLVPVLARNPQLRSVALGGCGQLSRRALGALAEGC-----PRLQRLSLAHCDW 152
Query: 217 VSSKMVRQILELCPNLEHLDLT----------------------------QTDISDSAFD 248
V +R + + CP LE LDLT ++ D+A
Sbjct: 153 VDGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDAAVQ 212
Query: 249 SWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTS 287
+ C L HLDL+GC ++ + ++ +L S
Sbjct: 213 ELA--RNCPELHHLDLTGCLRVGSDGVRTLAEYCPVLRS 249
Score = 35.0 bits (79), Expect = 0.18
Identities = 18/54 (33%), Positives = 29/54 (53%), Gaps = 2/54 (3%)
Query: 477 LSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLND 530
++L GC Q++ L L G P L+ L+L+ C + G L+ L CP+L +
Sbjct: 119 VALGGCGQLSRRALGALA--EGCPRLQRLSLAHCDWVDGLALRGLADRCPALEE 170
Score = 34.3 bits (77), Expect = 0.31
Identities = 20/78 (25%), Positives = 38/78 (48%), Gaps = 1/78 (1%)
Query: 203 GTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHL 262
G +++L LA ++ V V+++ CP L HLDLT + + + C LR L
Sbjct: 192 GAGLRSLSLAVNANVGDAAVQELARNCPELHHLDLTGC-LRVGSDGVRTLAEYCPVLRSL 250
Query: 263 DLSGCEKITDVALEKISR 280
+ C + + +L ++ +
Sbjct: 251 RVRHCHHVAESSLSRLRK 268
>gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens]
Length = 479
Score = 36.2 bits (82), Expect = 0.082
Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 15/74 (20%)
Query: 477 LSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDL-----------VSAC 525
L L C++IT+HG V+ + LP L L+LSGC +T G++ + +S C
Sbjct: 299 LRLLSCWEITNHG--VVNVVHSLPNLTALSLSGCSKVTDDGVELVAENLRKLRSLDLSWC 356
Query: 526 PSLNDEYFYY--CD 537
P + D Y CD
Sbjct: 357 PRITDMALEYVACD 370
Score = 33.5 bits (75), Expect = 0.53
Identities = 25/78 (32%), Positives = 41/78 (52%), Gaps = 3/78 (3%)
Query: 203 GTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQ-TDISDSAFDSWSWLGCCQSLRH 261
G S TL L +++ V ++ PNL L L+ + ++D + + + LR
Sbjct: 293 GHSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDDGVELVA--ENLRKLRS 350
Query: 262 LDLSGCEKITDVALEKIS 279
LDLS C +ITD+ALE ++
Sbjct: 351 LDLSWCPRITDMALEYVA 368
Score = 33.1 bits (74), Expect = 0.70
Identities = 27/90 (30%), Positives = 40/90 (44%), Gaps = 3/90 (3%)
Query: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYF 533
L LSLSGC ++TD G+ + + L L L+LS C IT L+ + L +
Sbjct: 322 LTALSLSGCSKVTDDGVEL--VAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVL 379
Query: 534 YYCDNINGPHADTASGCQNLQCGF-RACCR 562
C I S +L+ + R CC+
Sbjct: 380 DRCVRITDTGLSYLSTMSSLRSLYLRWCCQ 409
Score = 31.6 bits (70), Expect = 2.0
Identities = 57/257 (22%), Positives = 94/257 (36%), Gaps = 60/257 (23%)
Query: 85 EVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPATELDTEP 144
+++ +F Y + E C +QV W ++ W L PV A+ + P E
Sbjct: 100 KILNGLFWYFSACEKCVLAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGE----- 154
Query: 145 DDEWVKNRKDESRAFHEWD----EDADIDESEESAEES-----------IAISIAQMEKR 189
E+V + +R F + D DI E ++ S I+ A +E
Sbjct: 155 -KEFVNLQGFAARGFEGFCLVGVSDLDICEFIDNYALSKKGVKAMSLKRSTITDAGLEVM 213
Query: 190 L--LHGLIHNVLP----------YVGTSVKTLVLAYSSA--VSSKMVRQILELCPNLEHL 235
L + G++ L + S + L+ S V+ + I +L PNL L
Sbjct: 214 LEQMQGVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAEL 273
Query: 236 DLTQTDISDSAFDSWS-----------WLGCCQSLRH--------------LDLSGCEKI 270
L ++D+A ++ L C + H L LSGC K+
Sbjct: 274 SLQAYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKV 333
Query: 271 TDVALEKISRALGILTS 287
TD +E ++ L L S
Sbjct: 334 TDDGVELVAENLRKLRS 350
>gi|157168349 F-box and leucine-rich repeat protein 19 [Homo
sapiens]
Length = 694
Score = 35.8 bits (81), Expect = 0.11
Identities = 15/41 (36%), Positives = 21/41 (51%)
Query: 82 LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHL 122
LP L +F +L P+ELC C +V WS+ LW +
Sbjct: 424 LPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRM 464
Score = 31.2 bits (69), Expect = 2.6
Identities = 18/53 (33%), Positives = 28/53 (52%), Gaps = 3/53 (5%)
Query: 474 LLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACP 526
L+ L+L+GC+++TDH L L P L L+L C ++ L +A P
Sbjct: 629 LVHLNLAGCHRLTDH---CLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGP 678
>gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [Homo
sapiens]
Length = 1336
Score = 35.4 bits (80), Expect = 0.14
Identities = 14/38 (36%), Positives = 23/38 (60%)
Query: 85 EVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHL 122
EV +++FSYL+ Q+LC C +V W++ LW +
Sbjct: 1068 EVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRI 1105
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.131 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,372,635
Number of Sequences: 37866
Number of extensions: 990008
Number of successful extensions: 3606
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 3331
Number of HSP's gapped (non-prelim): 247
length of query: 565
length of database: 18,247,518
effective HSP length: 108
effective length of query: 457
effective length of database: 14,157,990
effective search space: 6470201430
effective search space used: 6470201430
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.