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Search of human proteins with 16262452
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16262452 cingulin [Homo sapiens]
(1203 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16262452 cingulin [Homo sapiens] 2295 0.0
gi|31982906 cingulin-like 1 [Homo sapiens] 468 e-131
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 281 2e-75
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 274 3e-73
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 274 3e-73
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 271 2e-72
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 271 2e-72
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 256 9e-68
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 244 5e-64
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 244 5e-64
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 244 5e-64
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 191 4e-48
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 187 4e-47
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 187 4e-47
gi|156104908 myosin heavy chain 6 [Homo sapiens] 186 9e-47
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 186 9e-47
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 186 1e-46
gi|148746195 trichohyalin [Homo sapiens] 186 1e-46
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 185 3e-46
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 184 6e-46
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 179 1e-44
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 173 8e-43
gi|21735548 centrosomal protein 2 [Homo sapiens] 173 1e-42
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 171 3e-42
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 164 4e-40
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 164 5e-40
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 164 5e-40
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 164 5e-40
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 164 5e-40
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 164 5e-40
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 2295 bits (5947), Expect = 0.0
Identities = 1203/1203 (100%), Positives = 1203/1203 (100%)
Query: 1 MEQAPNMAEPRGPVDHGVQIRFITEPVSGAEMGTLRRGGRRPAKDARASTYGVAVRVQGI 60
MEQAPNMAEPRGPVDHGVQIRFITEPVSGAEMGTLRRGGRRPAKDARASTYGVAVRVQGI
Sbjct: 1 MEQAPNMAEPRGPVDHGVQIRFITEPVSGAEMGTLRRGGRRPAKDARASTYGVAVRVQGI 60
Query: 61 AGQPFVVLNSGEKGGDSFGVQIKGANDQGASGALSSDLELPENPYSQVKGFPAPSQSSTS 120
AGQPFVVLNSGEKGGDSFGVQIKGANDQGASGALSSDLELPENPYSQVKGFPAPSQSSTS
Sbjct: 61 AGQPFVVLNSGEKGGDSFGVQIKGANDQGASGALSSDLELPENPYSQVKGFPAPSQSSTS 120
Query: 121 DEEPGAYWNGKLLRSHSQASLAGPGPVDPSNRSNSMLELAPKVASPGSTIDTAPLSSVDS 180
DEEPGAYWNGKLLRSHSQASLAGPGPVDPSNRSNSMLELAPKVASPGSTIDTAPLSSVDS
Sbjct: 121 DEEPGAYWNGKLLRSHSQASLAGPGPVDPSNRSNSMLELAPKVASPGSTIDTAPLSSVDS 180
Query: 181 LINKFDSQLGGQARGRTGRRTRMLPPEQRKRSKSLDSRLPRDTFEERERQSTNHWTSSTK 240
LINKFDSQLGGQARGRTGRRTRMLPPEQRKRSKSLDSRLPRDTFEERERQSTNHWTSSTK
Sbjct: 181 LINKFDSQLGGQARGRTGRRTRMLPPEQRKRSKSLDSRLPRDTFEERERQSTNHWTSSTK 240
Query: 241 YDNHVGTSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLR 300
YDNHVGTSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLR
Sbjct: 241 YDNHVGTSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLR 300
Query: 301 DQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAG 360
DQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAG
Sbjct: 301 DQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAG 360
Query: 361 QGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQS 420
QGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQS
Sbjct: 361 QGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQS 420
Query: 421 NKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVL 480
NKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVL
Sbjct: 421 NKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVL 480
Query: 481 EGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDH 540
EGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDH
Sbjct: 481 EGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDH 540
Query: 541 AVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEME 600
AVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEME
Sbjct: 541 AVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEME 600
Query: 601 EELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDR 660
EELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDR
Sbjct: 601 EELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDR 660
Query: 661 ELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAA 720
ELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAA
Sbjct: 661 ELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAA 720
Query: 721 VETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEA 780
VETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEA
Sbjct: 721 VETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEA 780
Query: 781 LNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAEL 840
LNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAEL
Sbjct: 781 LNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAEL 840
Query: 841 EEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASE 900
EEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASE
Sbjct: 841 EEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASE 900
Query: 901 AEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDR 960
AEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDR
Sbjct: 901 AEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDR 960
Query: 961 ARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDK 1020
ARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDK
Sbjct: 961 ARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDK 1020
Query: 1021 ISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLER 1080
ISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLER
Sbjct: 1021 ISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLER 1080
Query: 1081 KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHE 1140
KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHE
Sbjct: 1081 KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHE 1140
Query: 1141 VNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTESNLQT 1200
VNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTESNLQT
Sbjct: 1141 VNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTESNLQT 1200
Query: 1201 SSC 1203
SSC
Sbjct: 1201 SSC 1203
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 468 bits (1203), Expect = e-131
Identities = 280/741 (37%), Positives = 464/741 (62%), Gaps = 16/741 (2%)
Query: 449 QNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRV--EEQLRLRERELTALKGALKE 506
Q +L E AK++L L E ++ + K + E+ L+ R + +G
Sbjct: 543 QQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQG--NN 600
Query: 507 EVASRDQEVEHVRQQYQR---DTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEE 563
+ + EV+ + +Q + + +L+R +Q ++ ++ ER++M A + L+ + E
Sbjct: 601 QACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNE 660
Query: 564 TSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEE---LGEKIEVLQRELEQARAS 620
EE Q ++++ +LR +EL Q++ME+E+ + E L +++ + EL+ A+ S
Sbjct: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRS 720
Query: 621 AGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVE-ADRGREL 679
+ R+ L +ELL+ +++L++L ++ QE R R+REL L+ E + +E+
Sbjct: 721 --EDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEM 778
Query: 680 EEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRI 739
++ Q LQ LR+ EEA+K V + + Q +A E ++ QEEN++ + R
Sbjct: 779 DKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRS 838
Query: 740 LGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALE 799
LE+++ + + ++ + EA+ ++ L++ E E +QLEEAL +++EE +A+RALE
Sbjct: 839 EELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALE 898
Query: 800 ARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELE 859
LE AQ L++ QEQ+ L+ L+EE +Q+E LRR K E+E ++ L +T+++L KE+
Sbjct: 899 NELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMA 958
Query: 860 KIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLR 919
I E S+ + +LQ QL++YKEK RRE+A+ QRQ K+ EAEK+ ++QDE++ +
Sbjct: 959 DIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLME 1018
Query: 920 QALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELD 979
+ L+ Q +D A ++LL Q L+ LE E E K +DDR+R +K +E+KVS+LE EL+
Sbjct: 1019 EELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELE 1078
Query: 980 EEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEG 1039
EE+N +LL++R++R R+Q++QLR EL+QER+ARQDLECDKISLERQNKDLK+R+ EG
Sbjct: 1079 EERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEG 1138
Query: 1040 FQKPSAS--LSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVN 1097
+ S + Q+E++ L++RL++EER++ LQ +NR+LERKVKEL +Q++DE +
Sbjct: 1139 SYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLT 1198
Query: 1098 DQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKD-S 1156
DQKDQLSLR+KA+KRQV+EAEEEI+RL+ +KK QRE+EEQ ++NE LQ ++ S++KD
Sbjct: 1199 DQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLR 1258
Query: 1157 WRKASRSAAESALKNEGLSSD 1177
+K + ++ LS+D
Sbjct: 1259 LKKLPSKVLDDMDDDDDLSTD 1279
Score = 242 bits (617), Expect = 2e-63
Identities = 204/778 (26%), Positives = 386/778 (49%), Gaps = 86/778 (11%)
Query: 287 PTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQP 346
P+ ++TPDLL+ QQE + + K +Y L+EGS++++ + +RKV+LV EK+Q
Sbjct: 528 PSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQT 587
Query: 347 LVMVSSGSTKA--------------VAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGL 392
L ++GS + + + +LT +V ELQR+L EVK +Q ++ + +
Sbjct: 588 LKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERM 647
Query: 393 ERQLE-------EKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQV 445
LE EK EE S LQ+ LE +GE +++ +EL +K +Q + L+ Q+
Sbjct: 648 RANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQL 707
Query: 446 MELQNKLKHVQGPEP-AKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGAL 504
E+ ++L + E K L+++LL+ ++ L+++L K+ E+ LR RERELTALKGAL
Sbjct: 708 SEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGAL 767
Query: 505 KEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVL-------EAERQKMSALVRGL 557
KEEV+S DQE++ +++QY + + LR S+++AT++ VL E ++ V+ L
Sbjct: 768 KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
Query: 558 QRE---LEETSEETGHWQSMFQKNKEDLRA----TKQELLQLRMEKEEMEEELGEKIEVL 610
Q E L+ SEE + Q+ EDL+ K+ L + E ++EE L +
Sbjct: 828 QEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEAL---VHAR 884
Query: 611 QRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLR 670
+ E E A ++E + L +T +E K+L +E+ +E + + R L+
Sbjct: 885 KEEKEAVSARRALENELEAAQGNLSQTTQEQKQL-SEKLKEESEQKEQLRRLK------- 936
Query: 671 VEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQE 730
E+E + L KT+++L+++ + +A + E ++ L E +E
Sbjct: 937 ------NEMENERWHLGKTIEKLQKEMADIVEASRTSTLE----------LQNQLDEYKE 980
Query: 731 ENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGS 790
+N RR + +++QLKE + +++D+++ +E E + + A + + +
Sbjct: 981 KN---RRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQL 1037
Query: 791 LAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRT 850
L + LE LE + L ++ L + +E++ Q E+ ELEE++ D
Sbjct: 1038 LEQTLKDLEYELE----AKSHLKDDRSRLVKQMEDKVSQLEM------ELEEERNNSDLL 1087
Query: 851 VDRLNKELEKIGEDSKQALQQLQAQ--LEDYKEKARREVADAQRQAKDWASEAEKTSGGL 908
+R+++ E++ + + LQ+ A+ LE K R+ D + + + GL
Sbjct: 1088 SERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL 1147
Query: 909 -SRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQ---- 963
+++ I L L++ + +R +L L ++++ L + +++ S D+ Q
Sbjct: 1148 VVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLR 1207
Query: 964 LKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKI 1021
LK ++ +V E E+D +++ + L + D + L+ +L S ++DL K+
Sbjct: 1208 LKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQL---NSMKKDLRLKKL 1262
Score = 52.4 bits (124), Expect = 3e-06
Identities = 30/81 (37%), Positives = 49/81 (60%), Gaps = 14/81 (17%)
Query: 41 RPAKDARASTYGVAVRVQGIAGQPFVVLNSGEK--GGDSFGVQ--------IKGANDQGA 90
R +++++A +YGV++RVQGI G P++VLN+ E+ G SF I +
Sbjct: 30 RSSQNSKAGSYGVSIRVQGIDGHPYIVLNNTERCLAGTSFSENGPPFPPPVINNLPLHSS 89
Query: 91 SGAL----SSDLELPENPYSQ 107
+G++ S +L+LPENPY+Q
Sbjct: 90 NGSVPKENSEELQLPENPYAQ 110
Score = 50.4 bits (119), Expect = 1e-05
Identities = 60/258 (23%), Positives = 121/258 (46%), Gaps = 36/258 (13%)
Query: 946 LEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVN----------RG 995
L+ + E +++ ++ A+Q+ K + + D K V L+ +++ +G
Sbjct: 540 LKGQQELTQQTNEETAKQILYNYLKEGSTDND-DATKRKVNLVFEKIQTLKSRAAGSAQG 598
Query: 996 RDQVDQLRTELMQERSARQDLECDKISLERQNK-DLKTRLASSEGFQKPSASLSQLESQ- 1053
+Q +E+ + L + L+RQ + ++K + E ++ A+L +L SQ
Sbjct: 599 NNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQH 658
Query: 1054 NQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQ 1113
N+ ++E ++R L+ + +L + ++EL Q++ ER+ Q ++ L+ Q
Sbjct: 659 NEKVEENSTLQQR----LEESEGELRKNLEEL-FQVKMERE-------QHQTEIRDLQDQ 706
Query: 1114 VDEAEEEIERLDGLRKKAQRE----VEEQHEVNEQLQARI--KSLEKDSWRKASR--SAA 1165
+ E +E LD ++ RE +EE + + LQ + K ++D RK R +A
Sbjct: 707 LSEMHDE---LDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTAL 763
Query: 1166 ESALKNEGLSSDEEFDSV 1183
+ ALK E S D+E D +
Sbjct: 764 KGALKEEVSSHDQEMDKL 781
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 281 bits (720), Expect = 2e-75
Identities = 257/908 (28%), Positives = 440/908 (48%), Gaps = 140/908 (15%)
Query: 368 VEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNM 427
+ +L+ +L +E K RQ+LE ++ L+ + + ++ + LQ ++ K + + +ELQ
Sbjct: 1036 ISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGA 1095
Query: 428 KRLLDQGED----------LRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLE 477
L +G+D + L+ Q+ ELQ + + E +DL E E L+
Sbjct: 1096 ---LARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALK 1152
Query: 478 EVLEGK---QRVEEQLRL-RERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSM 533
LE +++LR RE+E+ LK AL+EE + + +++ +RQ++ E+L +
Sbjct: 1153 TELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQL 1212
Query: 534 QDATQDHAVLEAERQKMSALVRGLQRE---LEETSEETGHWQSMFQKNKEDLRATKQELL 590
+ A + A LE +Q + + L E L++ E+ H + ++L A E
Sbjct: 1213 EQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGD 1272
Query: 591 QLRMEKEEMEEELGEKIEVLQRELEQA-RASAGDTRQVEVLKKELLRTQEELKELQAERQ 649
+LR+E E +L +++ + LE+A + + L+ +L TQE L+E RQ
Sbjct: 1273 RLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQE--ETRQ 1330
Query: 650 SQEVAGRHRDRELEKQ-LAVLRVEADRGRE-LEEQNLQLQKTLQQLRQDCE--------- 698
++ R R E EK L + E + R+ LE+Q L LQ L ++ +
Sbjct: 1331 KLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESL 1390
Query: 699 EASKAKMVAEAEATVLGQRRAA-------VETTLRETQEENDEF-------RRRILGLEQ 744
E +K K++ +AEA L QR +E T Q+E D+ R+ LE+
Sbjct: 1391 EEAKKKLLKDAEA--LSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEK 1448
Query: 745 QLKETRGLVDGGEAVEARLRDKLQRLEAEKQQ-----------LEEALNASQEEEGS--- 790
+ K+ L+ +++ AR ++ R EAE ++ LEEAL A +E E
Sbjct: 1449 KQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQ 1508
Query: 791 ---------------------LAAAKRALEARLEEAQRGLARLGQE-QQTLNRALEEEGK 828
L +KRALE ++EE + L L E Q T + L E
Sbjct: 1509 LRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVN 1568
Query: 829 QREVLRRGKAEL-------EEQKRLLDRTVDRLNKELE---------------------- 859
+ + + + +L EE+KRLL + V L ELE
Sbjct: 1569 MQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKD 1628
Query: 860 ---------KIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSR 910
K ++ + L++LQAQ++DY+ RE+ +A+ + ++++++ L
Sbjct: 1629 LEAQIEAANKARDEVIKQLRKLQAQMKDYQ----RELEEARASRDEIFAQSKESEKKLKS 1684
Query: 911 LQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEK 970
L+ EI +L++ L +S+ R A +++ LA + A K D++ R LE +
Sbjct: 1685 LEAEILQLQEELASSERARRHAEQERDELADEITN---SASGKSALLDEKRR----LEAR 1737
Query: 971 VSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDL 1030
+++LE EL+EE++ +ELL DR + QVD L EL ERSA Q + + LERQNK+L
Sbjct: 1738 IAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKEL 1797
Query: 1031 KTRLASSEGFQKP--SASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQ 1088
K +L EG K A++S LE++ L+E+L+ E +E+ R+ E+K+KE+ +Q
Sbjct: 1798 KAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQ 1857
Query: 1089 IEDERQHVNDQKDQL---SLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQL 1145
+EDER+H + K+Q+ + R+K LKRQ++EAEEE R + R+K QRE+++ E NE L
Sbjct: 1858 VEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGL 1917
Query: 1146 QARIKSLE 1153
+ +L+
Sbjct: 1918 SREVSTLK 1925
Score = 179 bits (454), Expect = 1e-44
Identities = 212/938 (22%), Positives = 425/938 (45%), Gaps = 127/938 (13%)
Query: 340 VLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEV----KKRQKLEPSQVGLERQ 395
V K++PL+ V+ + A EL KV+E Q K++ E+ +K Q+L + L Q
Sbjct: 837 VFTKVKPLLQVTRQEEELQAKDEELL-KVKEKQTKVEGELEEMERKHQQLLEEKNILAEQ 895
Query: 396 LEEKTEECSRLQEL-----------------LERRKGEAQQSNKELQNMKR--------- 429
L+ +TE + +E+ LE R E ++ N+ LQN K+
Sbjct: 896 LQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDL 955
Query: 430 --LLDQGEDLRHGLETQVMELQNKLKHVQ------GPEPAKEVLLKDLLETR--ELLEEV 479
LD+ E R L+ + + + K+K ++ + +K + K L+E R E ++
Sbjct: 956 EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1015
Query: 480 LEGKQRVEEQLRLRERE---LTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQD- 535
E +++ + ++R ++ ++ L+ LK+E +R QE+E +++ +T L+ + +
Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTR-QELEKAKRKLDGETTDLQDQIAEL 1074
Query: 536 -ATQDHAVLE---AERQKMSALVRG----------------LQRELEETSEETGHWQSMF 575
A D L+ E + AL RG LQ ++ E E+ ++
Sbjct: 1075 QAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR 1134
Query: 576 QKNKEDLRATKQELLQLRMEKEE--------------MEEELGEKIEVLQRELEQARASA 621
K ++ R +EL L+ E E+ E+E+ E + L+ E + A
Sbjct: 1135 NKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQI 1194
Query: 622 GDTRQVEVLKKELLRTQ-EELKELQAERQSQEVAGRHRDRELEKQLAVL-RVEADRGREL 679
D RQ E L Q E+ K +A + + ++EL ++ VL +V+A E
Sbjct: 1195 QDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKA----ES 1250
Query: 680 EEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRI 739
E + +L +Q+L E + ++ +A+ L V T L E +++ +F +
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDA 1310
Query: 740 LGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALE 799
LE QL++T+ L+ + L ++++LE EK L+E +E +L AL+
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQ 1370
Query: 800 ARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELE 859
++L + ++ + ++L A ++ K E L + E L++T +RL +EL+
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430
Query: 860 KIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLR 919
+ D +Q+ + LE ++K + +A+ + + +A E ++ + + L
Sbjct: 1431 DLTVDLDHQ-RQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLA 1489
Query: 920 QAL-QASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETEL 978
+AL +A +A+ + R +K+L A + E+ S+DD + + LE+ LE ++
Sbjct: 1490 RALEEALEAKEEFERQNKQLRA--------DMEDLMSSKDDVGKNVHELEKSKRALEQQV 1541
Query: 979 DEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQ-NKDLKTRLASS 1037
+E R Q+++L EL A+ LE + +++ Q +DL+TR +
Sbjct: 1542 EEM--------------RTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQN 1587
Query: 1038 EGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVN 1097
E +K + Q+ L+ L+ E +++ + ++ +K+E +K+L QIE N
Sbjct: 1588 E--EKKRLLIKQVRE----LEAELEDERKQRALAVASKKKMEIDLKDLEAQIE----AAN 1637
Query: 1098 DQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSW 1157
+D++ +++ L+ Q+ + + E+E R + + +E + + L+A I L+++
Sbjct: 1638 KARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEE-- 1695
Query: 1158 RKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTE 1195
+++E A ++ DE D + + +S S L +
Sbjct: 1696 ----LASSERARRHAEQERDELADEITNSASGKSALLD 1729
Score = 132 bits (331), Expect = 3e-30
Identities = 181/737 (24%), Positives = 324/737 (43%), Gaps = 95/737 (12%)
Query: 468 DLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTE 527
++L + + ++GKQ E +R E + + + ++ R + H+ ++
Sbjct: 729 EILTPNAIPKGFMDGKQACERMIRALELDPNLYRIG-QSKIFFRAGVLAHLEEERDLKIT 787
Query: 528 QLRRSMQDATQDHAVLEA---ERQKMSALVRGLQRELEETSEETGHWQ--SMFQKNKEDL 582
+ Q + + +A ++Q++SAL + LQR + HWQ +F K K L
Sbjct: 788 DIIIFFQAVCRGYLARKAFAKKQQQLSAL-KVLQRNCAAYLK-LRHWQWWRVFTKVKPLL 845
Query: 583 RATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELK 642
+ T+QE EEL K E L + E+ G+ ++E ++LL + L
Sbjct: 846 QVTRQE------------EELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILA 893
Query: 643 E-LQAERQ----SQEVAGR--HRDRELEKQLAVLRV----EADRGRELEEQNLQLQKTLQ 691
E LQAE + ++E+ R + +ELE+ L L E +R + L+ + ++Q +Q
Sbjct: 894 EQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQ 953
Query: 692 QLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRG 751
L + +E A+ + E + +E + +++N +F + +E ++ E
Sbjct: 954 DLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSS 1013
Query: 752 LVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLA- 810
+ E L + E LEE L ++ L AKR L+ + Q +A
Sbjct: 1014 QLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAE 1073
Query: 811 ----------RLGQEQQTLNRALE-------EEGKQREVLRRGKAELEEQKRLLDRTVDR 853
+L ++++ L AL + +V+R +A++ E + +
Sbjct: 1074 LQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKAS 1133
Query: 854 LNKELEKIGEDSKQALQQLQAQLED----------YKEKARREVADAQRQAKDWASEAEK 903
NK EK D + L+ L+ +LED + K +EVA+ ++ + E+
Sbjct: 1134 RNK-AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE------EE 1186
Query: 904 TSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQ 963
T +++QD QR AL+ + + A+ K L + QGL E +NK + A +
Sbjct: 1187 TKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGL--ETDNK-----ELACE 1239
Query: 964 LKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISL 1023
+K L++ + E + + V+ L +V+ G D+LR EL ++ S Q+ E D +S
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAKVSEG----DRLRVELAEKASKLQN-ELDNVST 1294
Query: 1024 ---ERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLER 1080
E + K +K F K +AS LESQ Q QE LQ E R+K L S R+LE
Sbjct: 1295 LLEEAEKKGIK--------FAKDAAS---LESQLQDTQELLQEETRQKLNLSSRIRQLEE 1343
Query: 1081 KVKELSIQIEDE---RQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEE 1137
+ L Q E+E R+++ Q L ++ K++VD+ IE L+ +KK ++ E
Sbjct: 1344 EKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA 1403
Query: 1138 QHEVNEQLQARIKSLEK 1154
+ E+ LEK
Sbjct: 1404 LSQRLEEKALAYDKLEK 1420
Score = 131 bits (329), Expect = 4e-30
Identities = 167/699 (23%), Positives = 299/699 (42%), Gaps = 79/699 (11%)
Query: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECS-------RLQELLERRKG 415
+L + LQ + +EE + R+ LE + L+ QL + ++ L+E ++
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399
Query: 416 EAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKH----VQGPEPAKEVLLKDLLE 471
+A+ ++ L+ D+ E ++ L+ ++ +L L H E ++ + L E
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE 1459
Query: 472 TRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRR 531
+ + E + R E + R +E + +L AL+E + +++ E E +Q + D E L
Sbjct: 1460 EKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKE-EFERQNKQLRADMEDLMS 1518
Query: 532 SMQDATQDHAVLEAERQKMSALVRGLQRELEETSEE---TGHWQSMFQKNKEDLRATKQE 588
S D ++ LE ++ + V ++ +LEE +E T + + N + ++A +
Sbjct: 1519 SKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER 1578
Query: 589 LLQLRMEK-EEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAE 647
LQ R E+ EE + L +++ L+ ELE R R + V K+ + + +LK+L+A+
Sbjct: 1579 DLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ----RALAVASKK--KMEIDLKDLEAQ 1632
Query: 648 RQSQEVAGRHRDRELEKQLAVLRVEA-DRGRELEEQNLQLQKTLQQLRQDCEEASKAKMV 706
E A + RD E+ KQL L+ + D RELEE + Q + E+ K
Sbjct: 1633 I---EAANKARD-EVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK----ESEKKLKS 1684
Query: 707 AEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDK 766
EAE L + A+ E R ++E DE I + ++ L D+
Sbjct: 1685 LEAEILQLQEELASSERARRHAEQERDELADEITN--------------SASGKSALLDE 1730
Query: 767 LQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEE 826
+RLEA QLEE L +EE+ ++ L R + + L E A ++
Sbjct: 1731 KRRLEARIAQLEEEL---EEEQSNM----ELLNDRFRKTTLQVDTLNAELAAERSAAQKS 1783
Query: 827 GKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARRE 886
R+ L R EL+ + + L+ V K + AL+ QLE+ E+ +E
Sbjct: 1784 DNARQQLERQNKELKAKLQELEGAVKSKFKA-------TISALEAKIGQLEEQLEQEAKE 1836
Query: 887 VADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGL 946
A A + + + ++ +Q E +R Q E+ AR+ + L ++L+
Sbjct: 1837 RAAANKLVRRTEKKLKEIF-----MQVEDERRHADQYKEQMEKANARMKQ--LKRQLEEA 1889
Query: 947 EQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTEL 1006
E+EA S+ R+L E L E+ KN R+ RG
Sbjct: 1890 EEEATRANASRRKLQRELDDATEANEGLSREVSTLKN-------RLRRGGP------ISF 1936
Query: 1007 MQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSA 1045
RS R+ L + SLE + D +++ + Q P +
Sbjct: 1937 SSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQPPQS 1975
Score = 127 bits (318), Expect = 8e-29
Identities = 156/738 (21%), Positives = 308/738 (41%), Gaps = 82/738 (11%)
Query: 184 KFDSQLGG-QARGRTGRRTRMLPPEQRKRSKSLDSRLPRDT--FEERERQSTNHWTSSTK 240
K D+Q+ A+ G R R+ E +++ L + L + EE E++ +
Sbjct: 1256 KLDAQVQELHAKVSEGDRLRV---ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAAS 1312
Query: 241 YDNHVGTSKQPAQSQNLSPLSGFSRSRQTQDWV--LQSFEEPRRSAQDPTMLQFKSTPDL 298
++ + +++ Q + L+ SR RQ ++ LQ +E A+ Q +
Sbjct: 1313 LESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQ 1372
Query: 299 LRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAV 358
L D ++ VD TI E E++ + + + ++++ + K
Sbjct: 1373 LADTKK-----KVDDDLGTI-----ESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT- 1421
Query: 359 AGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQ 418
+ L +++++L LD + + LE Q ++ L E+ +R E +R + EA+
Sbjct: 1422 --KNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAR 1479
Query: 419 QSNKELQNMKRLLDQGEDLRHGLETQVMELQNKL-----------KHVQGPEPAKEVLLK 467
+ + ++ R L++ + + E Q +L+ + K+V E +K L +
Sbjct: 1480 EKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQ 1539
Query: 468 DLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTE 527
+ E R LEE+ + Q E+ E + A+K + ++ +RD++ E ++ +
Sbjct: 1540 QVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVR 1599
Query: 528 QLRRSMQDATQDHAVLEAERQKMSALVRGLQRELE-------ETSEETGHWQSM---FQK 577
+L ++D + A+ A ++KM ++ L+ ++E E ++ Q+ +Q+
Sbjct: 1600 ELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR 1659
Query: 578 NKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQREL---EQARASAGDTRQVEVLKKEL 634
E+ RA++ E+ E E+ + L +I LQ EL E+AR A R + L E+
Sbjct: 1660 ELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER--DELADEI 1717
Query: 635 LRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGR----------------- 677
+ L E++ E + ELE++ + + + DR R
Sbjct: 1718 TNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER 1777
Query: 678 -----------ELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLR 726
+LE QN +L+ LQ+L + SK K A +GQ +E +
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAVK--SKFKATISALEAKIGQLEEQLEQEAK 1835
Query: 727 ETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQE 786
E N RR E++LKE V+ + ++++++ A +QL+ L ++E
Sbjct: 1836 ERAAANKLVRRT----EKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEE 1891
Query: 787 EEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGK-QREVLRRGKAELEEQKR 845
E A++R L+ L++A L +E TL L G R G+ +L +
Sbjct: 1892 EATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGA 1951
Query: 846 LLDRTVDRLNKELEKIGE 863
L+ + D + + E
Sbjct: 1952 SLELSDDDTESKTSDVNE 1969
Score = 95.1 bits (235), Expect = 3e-19
Identities = 89/428 (20%), Positives = 186/428 (43%), Gaps = 20/428 (4%)
Query: 772 AEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQRE 831
A+KQQ AL Q + + R+ + L ++ ++++ L EE K +E
Sbjct: 807 AKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKE 866
Query: 832 VLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSK--QALQQLQAQLEDYKEKARREVAD 889
+ + ELEE +R + ++ N E++ +++ ++++A+L K++ + D
Sbjct: 867 KQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHD 926
Query: 890 AQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQE 949
+ + ++ + ++Q IQ L + L + R +L+K +++ +E+E
Sbjct: 927 LESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEE 986
Query: 950 AENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQE 1009
+ ++ K +E++++ ++L EE+ + L N+ + L L +E
Sbjct: 987 ILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKE 1046
Query: 1010 RSARQDLECDKISLERQNKDLKTRLASSEG-FQKPSASLSQLESQNQLLQERLQAEEREK 1068
RQ+LE K L+ + DL+ ++A + + L++ E + Q R E K
Sbjct: 1047 EKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHK 1106
Query: 1069 TVLQSTNRKLERKVKELSIQIEDE---RQHVNDQKDQLSLRVKALKRQVDEAEEEIERLD 1125
R+L+ ++ EL E E R QK LS ++ALK ++++ +
Sbjct: 1107 NNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ 1166
Query: 1126 GLRKKAQREVEE------------QHEVNEQLQARIKSLEK--DSWRKASRSAAESALKN 1171
LR K ++EV E + ++ + Q +LE+ + +A R A
Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226
Query: 1172 EGLSSDEE 1179
+GL +D +
Sbjct: 1227 QGLETDNK 1234
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 274 bits (701), Expect = 3e-73
Identities = 251/944 (26%), Positives = 431/944 (45%), Gaps = 148/944 (15%)
Query: 368 VEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNM 427
+ EL+ +L +E K RQ+LE + LE + E+ + LQ + K + + +ELQ
Sbjct: 1036 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095
Query: 428 KRLLDQGEDLRHGLETQVMELQNKLKHVQGP-----------EPAKEVLLKDLLETRELL 476
LD ++ ++ EL+ + +Q E K L ++L + L
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155
Query: 477 EEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDA 536
E+ L+ +E RE+E+T LK AL EE S + +V+ +RQ++ + E+L ++
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1215
Query: 537 TQDHAVLEAERQ---KMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLR 593
+ A L+ +Q K +A + G R L + +E H K+ L A QEL
Sbjct: 1216 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH-------KKKKLEAQVQELQSKC 1268
Query: 594 MEKEEMEEELGEKIEVLQRELEQARASAGDT--------RQVEVLKKELLRTQE------ 639
+ E EL +K+ LQ E+E + + V L +L TQE
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1328
Query: 640 --------ELKELQAER---QSQEVAGRHRDRELEKQLAVLRVEADRGRE---------- 678
+L++L+ ER Q Q + LE+ ++ L ++ ++
Sbjct: 1329 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1388
Query: 679 -LEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRR 737
LEE + QK ++ L Q EE + A E L Q + L ++ +
Sbjct: 1389 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1448
Query: 738 RILGLEQQLKETRGL----VDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGS--- 790
+ +Q L E + + D + EA R+K + + + LEEAL A +E E +
Sbjct: 1449 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1508
Query: 791 ---------------------LAAAKRALEARLEEAQRGLARLGQEQQTLNRA---LEE- 825
L +KRALE ++EE + L L E Q A LE
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568
Query: 826 ----EGKQREVLRRGKAELEEQKRLLDRTVDRLNKELE---------------------- 859
+G+ L+ + EE++R L R + ELE
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 860 ---------KIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSR 910
K E++ + L++LQAQ++D++ RE+ DA+ + + A++
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQ----RELEDARASRDEIFATAKENEKKAKS 1684
Query: 911 LQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEK 970
L+ ++ +L++ L A++ R A L+KE LA+ L + QD++ R LE +
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELAS---SLSGRNALQDEKRR----LEAR 1737
Query: 971 VSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDL 1030
+++LE EL+EE+ +E ++DRV + Q +QL EL ERS Q E + LERQNK+L
Sbjct: 1738 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1797
Query: 1031 KTRLASSEGFQKP--SASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQ 1088
+++L EG K ++++ LE++ L+E+++ E REK + ++ ++K+KE+ +Q
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Query: 1089 IEDERQHVNDQKDQL---SLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQL 1145
+EDER+ K+Q + RVK LKRQ++EAEEE +R++ R+K QRE++E E NE +
Sbjct: 1858 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Query: 1146 QARIKSLE-------KDSWRKASRSAAESALKNEGLSSDEEFDS 1182
+ +L+ + S+ + RS ++N S+EE D+
Sbjct: 1918 GREVNALKSKLRRGNETSFVPSRRSGGRRVIENAD-GSEEETDT 1960
Score = 179 bits (454), Expect = 1e-44
Identities = 185/841 (21%), Positives = 382/841 (45%), Gaps = 92/841 (10%)
Query: 359 AGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQ----------LEEKTEECSRLQE 408
A + ++ +++ +L+ +L+EE RQKL+ +V E + ++++ + S+ ++
Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 409 LLERRKGE----AQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEV 464
LLE R + + ++ +N+ +L ++ E + LE + L+ + K Q E K
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE---VRLKKEEKSRQELEKLKRK 1059
Query: 465 LLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQR 524
L D + E + ++ ++ QL +E EL A L +E+A ++ ++ +R + +
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEG 1118
Query: 525 DTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDL-- 582
L+ + E +++ + + L+ ELE+T + T Q + K ++++
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 583 --RATKQELLQLRMEKEEMEEELGEKIEVLQRELEQ-ARASAGDTRQVEVLKKELLRTQE 639
+A +E + +EM ++ + +E L +LEQ RA A + + L+KE
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238
Query: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE 699
EL+ L +Q E H+ ++LE Q+ L+ + G E +L + +L+ + E
Sbjct: 1239 ELRVLGQAKQEVE----HKKKKLEAQVQELQSKCSDG---ERARAELNDKVHKLQNEVES 1291
Query: 700 ASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAV 759
+ AE +A L + A++ + L++TQE E R+ L +
Sbjct: 1292 VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS---------------- 1335
Query: 760 EARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTL 819
KL++LE E+ L++ L+ E + +L L +L ++++ L + L
Sbjct: 1336 -----TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390
Query: 820 NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDY 879
+ K+ E L + E L++T +RL +EL+ + D +QL + LE
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKK 1449
Query: 880 KEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQAL-QASQAERDTARLDKEL 938
+ K + +A+ + + +A E ++ + + L +AL +A +A+ + R +K L
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 939 LAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQ 998
A E E+ S+DD + + LE+ LET+++E K Q
Sbjct: 1510 KA--------EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT--------------Q 1547
Query: 999 VDQLRTELMQERSARQDLECDKISLERQ-NKDLKTRLASSEGFQKPSASLSQLESQNQLL 1057
+++L EL A+ LE + +L+ Q +DL+ R +E ++ QL+ Q
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR------QLQRQLHEY 1601
Query: 1058 QERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEA 1117
+ L+ E +++ + + +KLE +K+L +Q + + +++ +++ L+ Q+ +
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK----GREEAIKQLRKLQAQMKDF 1657
Query: 1118 EEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSD 1177
+ E+E R + +E + + L+A + L++D +AAE A K L +
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED------LAAAERARKQADLEKE 1711
Query: 1178 E 1178
E
Sbjct: 1712 E 1712
Score = 136 bits (342), Expect = 1e-31
Identities = 165/682 (24%), Positives = 298/682 (43%), Gaps = 89/682 (13%)
Query: 545 AERQKMSALVRGLQRELEETSE-ETGHWQSMFQKNKEDLRATKQEL-LQLRMEKEEMEEE 602
A+RQ+ ++ +QR + W +F K K L+ T+QE +Q + ++ + +E
Sbjct: 807 AKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKE 866
Query: 603 LGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELK-ELQAERQSQEVAGRHRDRE 661
+K E +ELEQ + + +K LL+ Q + + EL AE + V + +E
Sbjct: 867 RQQKAENELKELEQKHSQLTE-------EKNLLQEQLQAETELYAEAEEMRVRLAAKKQE 919
Query: 662 LEKQL----AVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKA-------KMVAEAE 710
LE+ L A L E DRG++L+ + ++ + + L + EE A K+ AEA+
Sbjct: 920 LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 979
Query: 711 ATVLGQRRAAVETTLRETQEENDEFRRRILGL-------EQQLKETRGLVDGGEAVEARL 763
L ++ + +E RI L E++ K L + E++ + L
Sbjct: 980 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1039
Query: 764 RDKLQRLEAEKQQLEEALNASQEE-----------EGSLAAAKRALEARLEEAQRGLARL 812
+L++ E +Q+LE+ + + + +A K L + EE Q LARL
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099
Query: 813 GQEQQTLNRALE------------EEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEK 860
E N AL+ +E E R KA E+QKR L ++ L ELE
Sbjct: 1100 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA--EKQKRDLGEELEALKTELED 1157
Query: 861 IGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASE-AEKTSGGLSRLQDEIQRLR 919
DS Q+L+A+ E ++ + + R + E +K + + L +++++ +
Sbjct: 1158 T-LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1216
Query: 920 QALQASQAERDTARLDKELLAQRLQGL---EQEAENKKRSQDDRARQLKGLEEKVSRLET 976
+A + T + LA L+ L +QE E+KK K LE +V L++
Sbjct: 1217 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK----------KKLEAQVQELQS 1266
Query: 977 ELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLAS 1036
+ + + L D+V++ +++V+ + L + L D SL Q +D + L
Sbjct: 1267 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ-ELLQ 1325
Query: 1037 SEGFQK--PSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQ 1094
E QK S L QLE + LQ++L E K + LER + L+IQ+ D ++
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK-------QNLERHISTLNIQLSDSKK 1378
Query: 1095 HVND----------QKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQ 1144
+ D K + ++ L +Q +E ++L+ + + Q+E+++ +
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 1145 LQARIKSLEKDSWRKASRSAAE 1166
+ + +LEK RK + AE
Sbjct: 1439 QRQLVSNLEKKQ-RKFDQLLAE 1459
Score = 94.4 bits (233), Expect = 6e-19
Identities = 88/404 (21%), Positives = 182/404 (45%), Gaps = 9/404 (2%)
Query: 741 GLEQQLKETRGL--VDGGEAVEARLRDKLQRLE-AEKQQLEEALNASQEEEGSLAAAKRA 797
G+ L+E R L D A +A R L R A++QQ A+ Q + +
Sbjct: 773 GVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNW 832
Query: 798 LEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKE 857
RL + L ++ ++++ + +E K +E ++ + EL+E ++ + + N
Sbjct: 833 QWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 892
Query: 858 LEKIGEDSK--QALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEI 915
E++ +++ ++++ +L K++ + + + + ++ ++ ++ ++
Sbjct: 893 QEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM 952
Query: 916 QRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLE 975
L + L+ +A R +L+K +++ LE E + +++ K LEE++S L
Sbjct: 953 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1012
Query: 976 TELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLA 1035
T L EE+ + LT N+ + +L L +E +RQ+LE K LE D ++A
Sbjct: 1013 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA 1072
Query: 1036 SSEG-FQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQ 1094
+ + L++ E + Q RL E +K R+LE + +L ++ ER
Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1132
Query: 1095 HVN---DQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREV 1135
N QK L ++ALK ++++ + LR K ++EV
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV 1176
Score = 92.8 bits (229), Expect = 2e-18
Identities = 112/508 (22%), Positives = 216/508 (42%), Gaps = 71/508 (13%)
Query: 328 ESET---SVRRKVSLVLEKMQPLV----MVSSGSTKAVAGQGELTRKVEELQRKLDEEVK 380
E ET S+ R + LE + L M+ + V+ + ++ + V EL+ K
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE-------K 1532
Query: 381 KRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQ-NMKRLLDQGEDLRH 439
++ LE ++ QLEE +E ++ R + Q + + +++ +Q E+ R
Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1592
Query: 440 GLETQV----MELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRER 495
L+ Q+ EL+++ K AK+ L DL + + ++G++ +QLR +
Sbjct: 1593 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1652
Query: 496 ELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVR 555
++ + L++ ASRD E+ ++ ++ + L + +D A E R++
Sbjct: 1653 QMKDFQRELEDARASRD-EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL--- 1708
Query: 556 GLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELE 615
E EE +EE S +++ R + + QL +EE+EEE G +E + +
Sbjct: 1709 ----EKEELAEELASSLSGRNALQDEKRRLEARIAQL---EEELEEEQG-NMEAMSDRVR 1760
Query: 616 QARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADR 675
+A T+Q E L EL + ++ ++ RQ
Sbjct: 1761 KA------TQQAEQLSNELATERSTAQKNESARQ-------------------------- 1788
Query: 676 GRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEF 735
+LE QN +L+ L ++ + SK K A + Q VE RE Q
Sbjct: 1789 --QLERQNKELRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1844
Query: 736 RRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAK 795
+++ +++LKE V+ + + +++ ++ A +QL+ L ++EE + A +
Sbjct: 1845 KQK----DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1900
Query: 796 RALEARLEEAQRGLARLGQEQQTLNRAL 823
R L+ L+EA +G+E L L
Sbjct: 1901 RKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 84.7 bits (208), Expect = 5e-16
Identities = 76/311 (24%), Positives = 141/311 (45%), Gaps = 7/311 (2%)
Query: 869 LQQLQAQLEDY--KEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQ 926
L Q+ Q E+ KE ++ + Q++A++ E E+ L+ ++ +Q QA
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 927 AERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSR----LETELDEEK 982
AE + R+ Q L+ + E E + ++DR +QL+ +K+++ LE +L+EE+
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 983 NTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQK 1042
+ L ++ +L E++ L ++ LE + DL T LA E K
Sbjct: 964 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1023
Query: 1043 PSASL-SQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKD 1101
L ++ ES L+ RL+ EE+ + L+ RKLE + QI D + + + K
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 1102 QLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKAS 1161
QL+ + + L+ + ++EI + + KK + ++ E L + + K +K
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 1162 RSAAESALKNE 1172
ALK E
Sbjct: 1144 LGEELEALKTE 1154
Score = 67.8 bits (164), Expect = 6e-11
Identities = 59/280 (21%), Positives = 129/280 (46%), Gaps = 17/280 (6%)
Query: 917 RLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQL---KGLEEKVSR 973
+++ LQ ++ E + + EL Q+ + +Q+AEN+ + + + QL K L ++ +
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDEL--QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 897
Query: 974 LETELDEEKNTVEL-LTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKT 1032
ETEL E + + L + + + ++ L +E Q L+ ++ + +Q DL+
Sbjct: 898 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 1033 RLASSEGF-QKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIED 1091
+L E QK E++ + L++ + + + L + LE ++ +L+ + +
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 1092 ERQ---HVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQAR 1148
E + ++ K++ + L+ ++ + E+ + L+ L++K + + + HE LQA+
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 1149 IKSLEKDSWRKASRSAA-------ESALKNEGLSSDEEFD 1181
I L+ +K A E A KN L E +
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1117
Score = 67.0 bits (162), Expect = 1e-10
Identities = 87/407 (21%), Positives = 175/407 (42%), Gaps = 64/407 (15%)
Query: 256 NLSPLSG-FSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHM 314
N+ L G F R Q +D + EE RR Q + ++++ + R Q+ A
Sbjct: 1568 NMQALKGQFERDLQARD---EQNEEKRRQLQRQ-LHEYETELEDERKQRALAAAA----- 1618
Query: 315 KATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRK 374
K + G L++ +++++++ G +A+ +L ++++ QR+
Sbjct: 1619 KKKLEGDLKDLELQADSAIK------------------GREEAIKQLRKLQAQMKDFQRE 1660
Query: 375 LDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQG 434
L++ R ++ + E++ + + +LQE L + +Q++ E + + L
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1720
Query: 435 -------EDLRHGLETQVMELQNKLKHVQGPEPA-----------KEVLLKDLLETRELL 476
+D + LE ++ +L+ +L+ QG A E L +L R
Sbjct: 1721 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1780
Query: 477 EEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDA 536
++ +Q++E Q + +L ++GA+K + S +E Q + EQ R Q A
Sbjct: 1781 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1840
Query: 537 TQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEK 596
T+ L+ + +K+ ++ ++ E + M ++ KE + QL+ +
Sbjct: 1841 TKS---LKQKDKKLKEILLQVEDE-----------RKMAEQYKEQAEKGNARVKQLKRQL 1886
Query: 597 EEMEEE---LGEKIEVLQRELEQA-RASAGDTRQVEVLKKELLRTQE 639
EE EEE + LQREL++A ++ R+V LK +L R E
Sbjct: 1887 EEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 274 bits (701), Expect = 3e-73
Identities = 251/944 (26%), Positives = 431/944 (45%), Gaps = 148/944 (15%)
Query: 368 VEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNM 427
+ EL+ +L +E K RQ+LE + LE + E+ + LQ + K + + +ELQ
Sbjct: 1043 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102
Query: 428 KRLLDQGEDLRHGLETQVMELQNKLKHVQGP-----------EPAKEVLLKDLLETRELL 476
LD ++ ++ EL+ + +Q E K L ++L + L
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162
Query: 477 EEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDA 536
E+ L+ +E RE+E+T LK AL EE S + +V+ +RQ++ + E+L ++
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1222
Query: 537 TQDHAVLEAERQ---KMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLR 593
+ A L+ +Q K +A + G R L + +E H K+ L A QEL
Sbjct: 1223 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH-------KKKKLEAQVQELQSKC 1275
Query: 594 MEKEEMEEELGEKIEVLQRELEQARASAGDT--------RQVEVLKKELLRTQE------ 639
+ E EL +K+ LQ E+E + + V L +L TQE
Sbjct: 1276 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1335
Query: 640 --------ELKELQAER---QSQEVAGRHRDRELEKQLAVLRVEADRGRE---------- 678
+L++L+ ER Q Q + LE+ ++ L ++ ++
Sbjct: 1336 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1395
Query: 679 -LEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRR 737
LEE + QK ++ L Q EE + A E L Q + L ++ +
Sbjct: 1396 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1455
Query: 738 RILGLEQQLKETRGL----VDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGS--- 790
+ +Q L E + + D + EA R+K + + + LEEAL A +E E +
Sbjct: 1456 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1515
Query: 791 ---------------------LAAAKRALEARLEEAQRGLARLGQEQQTLNRA---LEE- 825
L +KRALE ++EE + L L E Q A LE
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1575
Query: 826 ----EGKQREVLRRGKAELEEQKRLLDRTVDRLNKELE---------------------- 859
+G+ L+ + EE++R L R + ELE
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 860 ---------KIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSR 910
K E++ + L++LQAQ++D++ RE+ DA+ + + A++
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQ----RELEDARASRDEIFATAKENEKKAKS 1691
Query: 911 LQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEK 970
L+ ++ +L++ L A++ R A L+KE LA+ L + QD++ R LE +
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELAS---SLSGRNALQDEKRR----LEAR 1744
Query: 971 VSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDL 1030
+++LE EL+EE+ +E ++DRV + Q +QL EL ERS Q E + LERQNK+L
Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1804
Query: 1031 KTRLASSEGFQKP--SASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQ 1088
+++L EG K ++++ LE++ L+E+++ E REK + ++ ++K+KE+ +Q
Sbjct: 1805 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Query: 1089 IEDERQHVNDQKDQL---SLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQL 1145
+EDER+ K+Q + RVK LKRQ++EAEEE +R++ R+K QRE++E E NE +
Sbjct: 1865 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Query: 1146 QARIKSLE-------KDSWRKASRSAAESALKNEGLSSDEEFDS 1182
+ +L+ + S+ + RS ++N S+EE D+
Sbjct: 1925 GREVNALKSKLRRGNETSFVPSRRSGGRRVIENAD-GSEEETDT 1967
Score = 179 bits (454), Expect = 1e-44
Identities = 185/841 (21%), Positives = 382/841 (45%), Gaps = 92/841 (10%)
Query: 359 AGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQ----------LEEKTEECSRLQE 408
A + ++ +++ +L+ +L+EE RQKL+ +V E + ++++ + S+ ++
Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 409 LLERRKGE----AQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEV 464
LLE R + + ++ +N+ +L ++ E + LE + L+ + K Q E K
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE---VRLKKEEKSRQELEKLKRK 1066
Query: 465 LLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQR 524
L D + E + ++ ++ QL +E EL A L +E+A ++ ++ +R + +
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEG 1125
Query: 525 DTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDL-- 582
L+ + E +++ + + L+ ELE+T + T Q + K ++++
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 583 --RATKQELLQLRMEKEEMEEELGEKIEVLQRELEQ-ARASAGDTRQVEVLKKELLRTQE 639
+A +E + +EM ++ + +E L +LEQ RA A + + L+KE
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245
Query: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE 699
EL+ L +Q E H+ ++LE Q+ L+ + G E +L + +L+ + E
Sbjct: 1246 ELRVLGQAKQEVE----HKKKKLEAQVQELQSKCSDG---ERARAELNDKVHKLQNEVES 1298
Query: 700 ASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAV 759
+ AE +A L + A++ + L++TQE E R+ L +
Sbjct: 1299 VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS---------------- 1342
Query: 760 EARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTL 819
KL++LE E+ L++ L+ E + +L L +L ++++ L + L
Sbjct: 1343 -----TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397
Query: 820 NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDY 879
+ K+ E L + E L++T +RL +EL+ + D +QL + LE
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKK 1456
Query: 880 KEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQAL-QASQAERDTARLDKEL 938
+ K + +A+ + + +A E ++ + + L +AL +A +A+ + R +K L
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 939 LAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQ 998
A E E+ S+DD + + LE+ LET+++E K Q
Sbjct: 1517 KA--------EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT--------------Q 1554
Query: 999 VDQLRTELMQERSARQDLECDKISLERQ-NKDLKTRLASSEGFQKPSASLSQLESQNQLL 1057
+++L EL A+ LE + +L+ Q +DL+ R +E ++ QL+ Q
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR------QLQRQLHEY 1608
Query: 1058 QERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEA 1117
+ L+ E +++ + + +KLE +K+L +Q + + +++ +++ L+ Q+ +
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK----GREEAIKQLRKLQAQMKDF 1664
Query: 1118 EEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSD 1177
+ E+E R + +E + + L+A + L++D +AAE A K L +
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED------LAAAERARKQADLEKE 1718
Query: 1178 E 1178
E
Sbjct: 1719 E 1719
Score = 136 bits (342), Expect = 1e-31
Identities = 165/682 (24%), Positives = 298/682 (43%), Gaps = 89/682 (13%)
Query: 545 AERQKMSALVRGLQRELEETSE-ETGHWQSMFQKNKEDLRATKQEL-LQLRMEKEEMEEE 602
A+RQ+ ++ +QR + W +F K K L+ T+QE +Q + ++ + +E
Sbjct: 814 AKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKE 873
Query: 603 LGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELK-ELQAERQSQEVAGRHRDRE 661
+K E +ELEQ + + +K LL+ Q + + EL AE + V + +E
Sbjct: 874 RQQKAENELKELEQKHSQLTE-------EKNLLQEQLQAETELYAEAEEMRVRLAAKKQE 926
Query: 662 LEKQL----AVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKA-------KMVAEAE 710
LE+ L A L E DRG++L+ + ++ + + L + EE A K+ AEA+
Sbjct: 927 LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 986
Query: 711 ATVLGQRRAAVETTLRETQEENDEFRRRILGL-------EQQLKETRGLVDGGEAVEARL 763
L ++ + +E RI L E++ K L + E++ + L
Sbjct: 987 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1046
Query: 764 RDKLQRLEAEKQQLEEALNASQEE-----------EGSLAAAKRALEARLEEAQRGLARL 812
+L++ E +Q+LE+ + + + +A K L + EE Q LARL
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106
Query: 813 GQEQQTLNRALE------------EEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEK 860
E N AL+ +E E R KA E+QKR L ++ L ELE
Sbjct: 1107 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA--EKQKRDLGEELEALKTELED 1164
Query: 861 IGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASE-AEKTSGGLSRLQDEIQRLR 919
DS Q+L+A+ E ++ + + R + E +K + + L +++++ +
Sbjct: 1165 T-LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1223
Query: 920 QALQASQAERDTARLDKELLAQRLQGL---EQEAENKKRSQDDRARQLKGLEEKVSRLET 976
+A + T + LA L+ L +QE E+KK K LE +V L++
Sbjct: 1224 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK----------KKLEAQVQELQS 1273
Query: 977 ELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLAS 1036
+ + + L D+V++ +++V+ + L + L D SL Q +D + L
Sbjct: 1274 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ-ELLQ 1332
Query: 1037 SEGFQK--PSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQ 1094
E QK S L QLE + LQ++L E K + LER + L+IQ+ D ++
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK-------QNLERHISTLNIQLSDSKK 1385
Query: 1095 HVND----------QKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQ 1144
+ D K + ++ L +Q +E ++L+ + + Q+E+++ +
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 1145 LQARIKSLEKDSWRKASRSAAE 1166
+ + +LEK RK + AE
Sbjct: 1446 QRQLVSNLEKKQ-RKFDQLLAE 1466
Score = 94.4 bits (233), Expect = 6e-19
Identities = 88/404 (21%), Positives = 182/404 (45%), Gaps = 9/404 (2%)
Query: 741 GLEQQLKETRGL--VDGGEAVEARLRDKLQRLE-AEKQQLEEALNASQEEEGSLAAAKRA 797
G+ L+E R L D A +A R L R A++QQ A+ Q + +
Sbjct: 780 GVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNW 839
Query: 798 LEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKE 857
RL + L ++ ++++ + +E K +E ++ + EL+E ++ + + N
Sbjct: 840 QWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 899
Query: 858 LEKIGEDSK--QALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEI 915
E++ +++ ++++ +L K++ + + + + ++ ++ ++ ++
Sbjct: 900 QEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM 959
Query: 916 QRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLE 975
L + L+ +A R +L+K +++ LE E + +++ K LEE++S L
Sbjct: 960 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1019
Query: 976 TELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLA 1035
T L EE+ + LT N+ + +L L +E +RQ+LE K LE D ++A
Sbjct: 1020 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA 1079
Query: 1036 SSEG-FQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQ 1094
+ + L++ E + Q RL E +K R+LE + +L ++ ER
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1139
Query: 1095 HVN---DQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREV 1135
N QK L ++ALK ++++ + LR K ++EV
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV 1183
Score = 92.8 bits (229), Expect = 2e-18
Identities = 112/508 (22%), Positives = 216/508 (42%), Gaps = 71/508 (13%)
Query: 328 ESET---SVRRKVSLVLEKMQPLV----MVSSGSTKAVAGQGELTRKVEELQRKLDEEVK 380
E ET S+ R + LE + L M+ + V+ + ++ + V EL+ K
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE-------K 1539
Query: 381 KRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQ-NMKRLLDQGEDLRH 439
++ LE ++ QLEE +E ++ R + Q + + +++ +Q E+ R
Sbjct: 1540 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1599
Query: 440 GLETQV----MELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRER 495
L+ Q+ EL+++ K AK+ L DL + + ++G++ +QLR +
Sbjct: 1600 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1659
Query: 496 ELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVR 555
++ + L++ ASRD E+ ++ ++ + L + +D A E R++
Sbjct: 1660 QMKDFQRELEDARASRD-EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL--- 1715
Query: 556 GLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELE 615
E EE +EE S +++ R + + QL +EE+EEE G +E + +
Sbjct: 1716 ----EKEELAEELASSLSGRNALQDEKRRLEARIAQL---EEELEEEQG-NMEAMSDRVR 1767
Query: 616 QARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADR 675
+A T+Q E L EL + ++ ++ RQ
Sbjct: 1768 KA------TQQAEQLSNELATERSTAQKNESARQ-------------------------- 1795
Query: 676 GRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEF 735
+LE QN +L+ L ++ + SK K A + Q VE RE Q
Sbjct: 1796 --QLERQNKELRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1851
Query: 736 RRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAK 795
+++ +++LKE V+ + + +++ ++ A +QL+ L ++EE + A +
Sbjct: 1852 KQK----DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1907
Query: 796 RALEARLEEAQRGLARLGQEQQTLNRAL 823
R L+ L+EA +G+E L L
Sbjct: 1908 RKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 84.7 bits (208), Expect = 5e-16
Identities = 76/311 (24%), Positives = 141/311 (45%), Gaps = 7/311 (2%)
Query: 869 LQQLQAQLEDY--KEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQ 926
L Q+ Q E+ KE ++ + Q++A++ E E+ L+ ++ +Q QA
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 927 AERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSR----LETELDEEK 982
AE + R+ Q L+ + E E + ++DR +QL+ +K+++ LE +L+EE+
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 983 NTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQK 1042
+ L ++ +L E++ L ++ LE + DL T LA E K
Sbjct: 971 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030
Query: 1043 PSASL-SQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKD 1101
L ++ ES L+ RL+ EE+ + L+ RKLE + QI D + + + K
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 1102 QLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKAS 1161
QL+ + + L+ + ++EI + + KK + ++ E L + + K +K
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 1162 RSAAESALKNE 1172
ALK E
Sbjct: 1151 LGEELEALKTE 1161
Score = 67.8 bits (164), Expect = 6e-11
Identities = 59/280 (21%), Positives = 129/280 (46%), Gaps = 17/280 (6%)
Query: 917 RLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQL---KGLEEKVSR 973
+++ LQ ++ E + + EL Q+ + +Q+AEN+ + + + QL K L ++ +
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDEL--QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 904
Query: 974 LETELDEEKNTVEL-LTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKT 1032
ETEL E + + L + + + ++ L +E Q L+ ++ + +Q DL+
Sbjct: 905 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 1033 RLASSEGF-QKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIED 1091
+L E QK E++ + L++ + + + L + LE ++ +L+ + +
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 1092 ERQ---HVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQAR 1148
E + ++ K++ + L+ ++ + E+ + L+ L++K + + + HE LQA+
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 1149 IKSLEKDSWRKASRSAA-------ESALKNEGLSSDEEFD 1181
I L+ +K A E A KN L E +
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1124
Score = 67.0 bits (162), Expect = 1e-10
Identities = 87/407 (21%), Positives = 175/407 (42%), Gaps = 64/407 (15%)
Query: 256 NLSPLSG-FSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHM 314
N+ L G F R Q +D + EE RR Q + ++++ + R Q+ A
Sbjct: 1575 NMQALKGQFERDLQARD---EQNEEKRRQLQRQ-LHEYETELEDERKQRALAAAA----- 1625
Query: 315 KATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRK 374
K + G L++ +++++++ G +A+ +L ++++ QR+
Sbjct: 1626 KKKLEGDLKDLELQADSAIK------------------GREEAIKQLRKLQAQMKDFQRE 1667
Query: 375 LDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQG 434
L++ R ++ + E++ + + +LQE L + +Q++ E + + L
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1727
Query: 435 -------EDLRHGLETQVMELQNKLKHVQGPEPA-----------KEVLLKDLLETRELL 476
+D + LE ++ +L+ +L+ QG A E L +L R
Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTA 1787
Query: 477 EEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDA 536
++ +Q++E Q + +L ++GA+K + S +E Q + EQ R Q A
Sbjct: 1788 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1847
Query: 537 TQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEK 596
T+ L+ + +K+ ++ ++ E + M ++ KE + QL+ +
Sbjct: 1848 TKS---LKQKDKKLKEILLQVEDE-----------RKMAEQYKEQAEKGNARVKQLKRQL 1893
Query: 597 EEMEEE---LGEKIEVLQRELEQA-RASAGDTRQVEVLKKELLRTQE 639
EE EEE + LQREL++A ++ R+V LK +L R E
Sbjct: 1894 EEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 271 bits (694), Expect = 2e-72
Identities = 243/908 (26%), Positives = 416/908 (45%), Gaps = 140/908 (15%)
Query: 368 VEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNM 427
+ EL+ +L +E K RQ+LE + LE + E+ + LQ + K + + +ELQ
Sbjct: 1043 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102
Query: 428 KRLLDQGEDLRHGLETQVMELQNKLKHVQGP-----------EPAKEVLLKDLLETRELL 476
LD ++ ++ EL+ + +Q E K L ++L + L
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162
Query: 477 EEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDA 536
E+ L+ +E RE+E+T LK AL EE S + +V+ +RQ++ + E+L ++
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1222
Query: 537 TQDHAVLEAERQ---KMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLR 593
+ A L+ +Q K +A + G R L + +E H K+ L A QEL
Sbjct: 1223 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH-------KKKKLEAQVQELQSKC 1275
Query: 594 MEKEEMEEELGEKIEVLQRELEQARASAGDT--------RQVEVLKKELLRTQE------ 639
+ E EL +K+ LQ E+E + + V L +L TQE
Sbjct: 1276 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1335
Query: 640 --------ELKELQAER---QSQEVAGRHRDRELEKQLAVLRVEADRGRE---------- 678
+L++L+ ER Q Q + LE+ ++ L ++ ++
Sbjct: 1336 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1395
Query: 679 -LEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRR 737
LEE + QK ++ L Q EE + A E L Q + L ++ +
Sbjct: 1396 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1455
Query: 738 RILGLEQQLKETRGL----VDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGS--- 790
+ +Q L E + + D + EA R+K + + + LEEAL A +E E +
Sbjct: 1456 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1515
Query: 791 ---------------------LAAAKRALEARLEEAQRGLARLGQEQQTLNRA---LEE- 825
L +KRALE ++EE + L L E Q A LE
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1575
Query: 826 ----EGKQREVLRRGKAELEEQKRLLDRTVDRLNKELE---------------------- 859
+G+ L+ + EE++R L R + ELE
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 860 ---------KIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSR 910
K E++ + L++LQAQ++D++ RE+ DA+ + + A++
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQ----RELEDARASRDEIFATAKENEKKAKS 1691
Query: 911 LQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEK 970
L+ ++ +L++ L A++ R A L+KE LA+ L + QD++ R LE +
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELAS---SLSGRNALQDEKRR----LEAR 1744
Query: 971 VSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDL 1030
+++LE EL+EE+ +E ++DRV + Q +QL EL ERS Q E + LERQNK+L
Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1804
Query: 1031 KTRLASSEGFQKP--SASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQ 1088
+++L EG K ++++ LE++ L+E+++ E REK + ++ ++K+KE+ +Q
Sbjct: 1805 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Query: 1089 IEDERQHVNDQKDQL---SLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQL 1145
+EDER+ K+Q + RVK LKRQ++EAEEE +R++ R+K QRE++E E NE +
Sbjct: 1865 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Query: 1146 QARIKSLE 1153
+ +L+
Sbjct: 1925 GREVNALK 1932
Score = 179 bits (454), Expect = 1e-44
Identities = 185/841 (21%), Positives = 382/841 (45%), Gaps = 92/841 (10%)
Query: 359 AGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQ----------LEEKTEECSRLQE 408
A + ++ +++ +L+ +L+EE RQKL+ +V E + ++++ + S+ ++
Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 409 LLERRKGE----AQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEV 464
LLE R + + ++ +N+ +L ++ E + LE + L+ + K Q E K
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE---VRLKKEEKSRQELEKLKRK 1066
Query: 465 LLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQR 524
L D + E + ++ ++ QL +E EL A L +E+A ++ ++ +R + +
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEG 1125
Query: 525 DTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDL-- 582
L+ + E +++ + + L+ ELE+T + T Q + K ++++
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 583 --RATKQELLQLRMEKEEMEEELGEKIEVLQRELEQ-ARASAGDTRQVEVLKKELLRTQE 639
+A +E + +EM ++ + +E L +LEQ RA A + + L+KE
Sbjct: 1186 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1245
Query: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE 699
EL+ L +Q E H+ ++LE Q+ L+ + G E +L + +L+ + E
Sbjct: 1246 ELRVLGQAKQEVE----HKKKKLEAQVQELQSKCSDG---ERARAELNDKVHKLQNEVES 1298
Query: 700 ASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAV 759
+ AE +A L + A++ + L++TQE E R+ L +
Sbjct: 1299 VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS---------------- 1342
Query: 760 EARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTL 819
KL++LE E+ L++ L+ E + +L L +L ++++ L + L
Sbjct: 1343 -----TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397
Query: 820 NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDY 879
+ K+ E L + E L++T +RL +EL+ + D +QL + LE
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKK 1456
Query: 880 KEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQAL-QASQAERDTARLDKEL 938
+ K + +A+ + + +A E ++ + + L +AL +A +A+ + R +K L
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 939 LAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQ 998
A E E+ S+DD + + LE+ LET+++E K Q
Sbjct: 1517 KA--------EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT--------------Q 1554
Query: 999 VDQLRTELMQERSARQDLECDKISLERQ-NKDLKTRLASSEGFQKPSASLSQLESQNQLL 1057
+++L EL A+ LE + +L+ Q +DL+ R +E ++ QL+ Q
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR------QLQRQLHEY 1608
Query: 1058 QERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEA 1117
+ L+ E +++ + + +KLE +K+L +Q + + +++ +++ L+ Q+ +
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK----GREEAIKQLRKLQAQMKDF 1664
Query: 1118 EEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSD 1177
+ E+E R + +E + + L+A + L++D +AAE A K L +
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED------LAAAERARKQADLEKE 1718
Query: 1178 E 1178
E
Sbjct: 1719 E 1719
Score = 178 bits (451), Expect = 3e-44
Identities = 213/960 (22%), Positives = 414/960 (43%), Gaps = 145/960 (15%)
Query: 343 KMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVK----KRQKLEPSQVGLERQLEE 398
K++PL+ V+ + A + EL +K +E Q+K + E+K K +L + L+ QL+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDEL-QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 399 KTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLET-------QVMELQNK 451
+TE + +E+ R + Q+ + L M+ L++ ED L+ Q+++L+ +
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 452 LKHVQGPEPA----------------KEVLLKD-----LLETRELLEE--------VLEG 482
L+ + E+L+ D L + R+LLEE + E
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 483 KQRVEEQLRLRERE---LTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQD 539
+++ + +L+ + ++ L+ LK+E SR QE+E ++++ + D + D
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 540 HAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKE------DLRATKQELLQLR 593
A L+ + K LQ L +E + +K +E DL+ R
Sbjct: 1085 IAELKMQLAKKE---EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 594 MEKEEMEEELGEKIEVLQRELE--------QARASAGDTRQVEVLKKEL----------- 634
+ E+ + +LGE++E L+ ELE Q A ++V VLKK L
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201
Query: 635 -------LRTQEELKELQAERQSQEVAGRHRDRE-LEKQLA----VLRVEADRGRELEEQ 682
+ EEL E Q E+ + A ++++ LEK+ A LRV +E+E +
Sbjct: 1202 QEMRQKHAQAVEELTE-QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 683 NLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGL 742
+L+ +Q+L+ C + +A+ + L +V L E + + + + + L
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 743 EQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARL 802
QL++T+ L+ + + KL++LE E+ L++ L+ E + +L L +L
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1380
Query: 803 EEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIG 862
++++ L + L + K+ E L + E L++T +RL +EL+ +
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440
Query: 863 EDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQAL 922
D +QL + LE + K + +A+ + + +A E ++ + + L +AL
Sbjct: 1441 VDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499
Query: 923 Q-ASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEE 981
+ A +A+ + R +K L A E E+ S+DD + + LE+ LET+++E
Sbjct: 1500 EEALEAKEELERTNKMLKA--------EMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551
Query: 982 KNTVELLTDRVNRGRD------------------------------------QVDQLRTE 1005
K +E L D + D Q+ + TE
Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1611
Query: 1006 LMQERSARQDLECDKISLERQNKDLKTRLASS-EGFQKPSASLSQLESQNQLLQERLQAE 1064
L ER R K LE KDL+ + S+ +G ++ L +L++Q + Q L+
Sbjct: 1612 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671
Query: 1065 EREKTVLQSTNRKLERKVKELSIQI----------EDERQHVNDQKDQLSLRVKALKRQV 1114
+ + +T ++ E+K K L + E R+ + +K++L+ + +
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731
Query: 1115 DEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAE--SALKNE 1172
+ ++E RL+ + + E+EE+ E + R++ + + + ++ A E +A KNE
Sbjct: 1732 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791
Score = 136 bits (342), Expect = 1e-31
Identities = 165/682 (24%), Positives = 298/682 (43%), Gaps = 89/682 (13%)
Query: 545 AERQKMSALVRGLQRELEETSE-ETGHWQSMFQKNKEDLRATKQEL-LQLRMEKEEMEEE 602
A+RQ+ ++ +QR + W +F K K L+ T+QE +Q + ++ + +E
Sbjct: 814 AKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKE 873
Query: 603 LGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELK-ELQAERQSQEVAGRHRDRE 661
+K E +ELEQ + + +K LL+ Q + + EL AE + V + +E
Sbjct: 874 RQQKAENELKELEQKHSQLTE-------EKNLLQEQLQAETELYAEAEEMRVRLAAKKQE 926
Query: 662 LEKQL----AVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKA-------KMVAEAE 710
LE+ L A L E DRG++L+ + ++ + + L + EE A K+ AEA+
Sbjct: 927 LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 986
Query: 711 ATVLGQRRAAVETTLRETQEENDEFRRRILGL-------EQQLKETRGLVDGGEAVEARL 763
L ++ + +E RI L E++ K L + E++ + L
Sbjct: 987 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1046
Query: 764 RDKLQRLEAEKQQLEEALNASQEE-----------EGSLAAAKRALEARLEEAQRGLARL 812
+L++ E +Q+LE+ + + + +A K L + EE Q LARL
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106
Query: 813 GQEQQTLNRALE------------EEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEK 860
E N AL+ +E E R KA E+QKR L ++ L ELE
Sbjct: 1107 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA--EKQKRDLGEELEALKTELED 1164
Query: 861 IGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASE-AEKTSGGLSRLQDEIQRLR 919
DS Q+L+A+ E ++ + + R + E +K + + L +++++ +
Sbjct: 1165 T-LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1223
Query: 920 QALQASQAERDTARLDKELLAQRLQGL---EQEAENKKRSQDDRARQLKGLEEKVSRLET 976
+A + T + LA L+ L +QE E+KK K LE +V L++
Sbjct: 1224 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK----------KKLEAQVQELQS 1273
Query: 977 ELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLAS 1036
+ + + L D+V++ +++V+ + L + L D SL Q +D + L
Sbjct: 1274 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ-ELLQ 1332
Query: 1037 SEGFQK--PSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQ 1094
E QK S L QLE + LQ++L E K + LER + L+IQ+ D ++
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK-------QNLERHISTLNIQLSDSKK 1385
Query: 1095 HVND----------QKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQ 1144
+ D K + ++ L +Q +E ++L+ + + Q+E+++ +
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 1145 LQARIKSLEKDSWRKASRSAAE 1166
+ + +LEK RK + AE
Sbjct: 1446 QRQLVSNLEKKQ-RKFDQLLAE 1466
Score = 132 bits (331), Expect = 3e-30
Identities = 148/698 (21%), Positives = 294/698 (42%), Gaps = 55/698 (7%)
Query: 191 GQARGRTGRRTRMLPPE-QRKRSKSLDSRLPRDTFEERERQSTNHWTSSTKYDNHV---- 245
GQA+ + + L + Q +SK D R ++ + N S T N
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 246 --------GTSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPD 297
S Q +Q L L +R + L+ EE R S QD + ++ +
Sbjct: 1311 IKLAKDVASLSSQLQDTQEL--LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Query: 298 LLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKA 357
L R S K + E E + ++++ + ++ + ++ K
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK---AAAYDKL 1425
Query: 358 VAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEA 417
+ L +++++L LD + + LE Q ++ L E+ S+ + +R + EA
Sbjct: 1426 EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1485
Query: 418 QQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKL-----------KHVQGPEPAKEVLL 466
++ + ++ R L++ + + LE L+ ++ K+V E +K L
Sbjct: 1486 REKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1545
Query: 467 KDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDT 526
+ E + LEE+ + Q E+ E + ALKG + ++ +RD++ E R+Q QR
Sbjct: 1546 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605
Query: 527 EQLRRSMQDATQDHAVLEAERQKMSALVRGLQREL-------EETSEETGHWQSM---FQ 576
+ ++D + A+ A ++K+ ++ L+ + EE ++ Q+ FQ
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Query: 577 KNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQA-RASAGDTRQVEVLKKELL 635
+ ED RA++ E+ E E+ + L + LQ +L A RA + E L +EL
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 636 RTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQ 695
+ LQ E++ E + ELE++ + +DR R+ +Q QL L R
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 696 DCEEASKAKMVAEAEATVL--------GQRRAAVETTLRETQEENDEFRRRILGLEQQLK 747
++ A+ E + L G ++ ++T+ + + + ++ EQ+ +
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV---EQEAR 1842
Query: 748 ETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQR 807
E + + + +L++ L ++E E++ E+ Q E+G+ A + L+ +LEEA+
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQY--KEQAEKGN--ARVKQLKRQLEEAEE 1898
Query: 808 GLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKR 845
R+ ++ L R L+E + E + R L+ + R
Sbjct: 1899 ESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 123 bits (309), Expect = 9e-28
Identities = 169/796 (21%), Positives = 324/796 (40%), Gaps = 134/796 (16%)
Query: 311 VDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE 370
++ +K + L +++ E +R+ + + K S + + + + VEE
Sbjct: 1155 LEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1214
Query: 371 LQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRL 430
L +L++ + + L+ ++ LE++ + E L + + + + ++ ++Q ++
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274
Query: 431 LDQGEDLRHGLETQVMELQNKLKHVQGP---------EPAKEV--LLKDLLETRELLEEV 479
GE R L +V +LQN+++ V G + AK+V L L +T+ELL+E
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1334
Query: 480 LEGKQRVEEQLRLRERELTALKGALKEEVASRD--------------------------- 512
K V +LR E E +L+ L EE+ ++
Sbjct: 1335 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394
Query: 513 -----------QEVEHVRQQYQRDT------EQLRRSMQDATQDHAV-LEAERQKMSALV 554
+E+E++ QQY+ E+ + +Q D V L+ +RQ +S L
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1454
Query: 555 RGLQRELEETSEETGHWQSMF--QKNKEDLRATKQELLQLRM-----EKEEMEEELGEKI 607
+ QR+ ++ E + S + ++++ + A ++E L + E E +EEL
Sbjct: 1455 KK-QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1513
Query: 608 EVLQRELEQARASAGDT----RQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELE 663
++L+ E+E +S D ++E K+ L EE+K E + + A LE
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573
Query: 664 KQLAVLRVEADRGREL-----EEQNLQLQKTLQQLRQDCEEASKAKMVA----------- 707
+ L+ + +R + EE+ QLQ+ L + + E+ K + +A
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633
Query: 708 -----EAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEAR 762
+A++ + G+ A + LR+ Q + +F+R + E E
Sbjct: 1634 KDLELQADSAIKGREEAIKQ--LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691
Query: 763 LRDKLQRLEA--------------EKQQLEEALNASQEEEGSLAAAKRALEAR------- 801
L L +L+ EK++L E L +S +L KR LEAR
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Query: 802 LEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEK- 860
LEE Q + + + + E+ + R + E ++ L+R L +L +
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811
Query: 861 ---IGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQR 917
+ K + L+A++ +E+ +E + Q K + +K L +++DE +
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1871
Query: 918 LRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETE 977
Q QAE+ AR+ K+L Q LE+ E +R +R +L+ E
Sbjct: 1872 AEQ--YKEQAEKGNARV-KQLKRQ----LEEAEEESQRINANR-----------RKLQRE 1913
Query: 978 LDEEKNTVELLTDRVN 993
LDE + E + VN
Sbjct: 1914 LDEATESNEAMGREVN 1929
Score = 122 bits (306), Expect = 2e-27
Identities = 146/689 (21%), Positives = 291/689 (42%), Gaps = 85/689 (12%)
Query: 317 TIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE----LQ 372
++ G+L E ++ + + V+ + ++Q + T+ R++EE LQ
Sbjct: 1298 SVTGMLNEAEGKA-IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356
Query: 373 RKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLD 432
+LDEE++ +Q LE L QL + ++ +E + ++ KE++N+ + +
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416
Query: 433 QG-----------EDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLE 481
+ L+ L+ V++L N+ + V E + + L E + + + +
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476
Query: 482 GKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHA 541
+ R E + R +E + +L AL+E + +++ E+E + + + E L S D ++
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 542 VLEAERQKMSALVRGLQRELEETSEE---TGHWQSMFQKNKEDLRATKQELLQLRMEKEE 598
LE ++ + + ++ +LEE +E T + + N + L+ + LQ R E+ E
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 599 MEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQE-ELKELQAERQSQEVAGRH 657
EK LQR+L + D R+ L + E +LK+L+ + S + GR
Sbjct: 1596 ------EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA-IKGRE 1648
Query: 658 RDRELEKQLAVLRVEA-DRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQ 716
E KQL L+ + D RELE+ + + E KAK + EA+ L +
Sbjct: 1649 ---EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK---ENEKKAKSL-EADLMQLQE 1701
Query: 717 RRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQ 776
AA E ++ E +E +E + G A L+ EK++
Sbjct: 1702 DLAAAERARKQADLEKEELA----------EELASSLSGRNA-----------LQDEKRR 1740
Query: 777 LEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRG 836
LE + +EE A+ R+ +A + +L E T ++ R+ L R
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1800
Query: 837 KAELEEQ--------KRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARR--- 885
EL + K T+ L ++ ++ E +Q ++ QA + K+K ++
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 886 ---EVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQR 942
+V D ++ A+ + +AEK + + +L+ +++ + Q A R
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR------------- 1907
Query: 943 LQGLEQEAENKKRSQDDRARQLKGLEEKV 971
+ L++E + S + R++ L+ K+
Sbjct: 1908 -RKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 94.4 bits (233), Expect = 6e-19
Identities = 88/404 (21%), Positives = 182/404 (45%), Gaps = 9/404 (2%)
Query: 741 GLEQQLKETRGL--VDGGEAVEARLRDKLQRLE-AEKQQLEEALNASQEEEGSLAAAKRA 797
G+ L+E R L D A +A R L R A++QQ A+ Q + +
Sbjct: 780 GVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNW 839
Query: 798 LEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKE 857
RL + L ++ ++++ + +E K +E ++ + EL+E ++ + + N
Sbjct: 840 QWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 899
Query: 858 LEKIGEDSK--QALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEI 915
E++ +++ ++++ +L K++ + + + + ++ ++ ++ ++
Sbjct: 900 QEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM 959
Query: 916 QRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLE 975
L + L+ +A R +L+K +++ LE E + +++ K LEE++S L
Sbjct: 960 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1019
Query: 976 TELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLA 1035
T L EE+ + LT N+ + +L L +E +RQ+LE K LE D ++A
Sbjct: 1020 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA 1079
Query: 1036 SSEG-FQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQ 1094
+ + L++ E + Q RL E +K R+LE + +L ++ ER
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1139
Query: 1095 HVN---DQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREV 1135
N QK L ++ALK ++++ + LR K ++EV
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV 1183
Score = 67.8 bits (164), Expect = 6e-11
Identities = 59/280 (21%), Positives = 129/280 (46%), Gaps = 17/280 (6%)
Query: 917 RLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQL---KGLEEKVSR 973
+++ LQ ++ E + + EL Q+ + +Q+AEN+ + + + QL K L ++ +
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDEL--QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 904
Query: 974 LETELDEEKNTVEL-LTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKT 1032
ETEL E + + L + + + ++ L +E Q L+ ++ + +Q DL+
Sbjct: 905 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 1033 RLASSEGF-QKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIED 1091
+L E QK E++ + L++ + + + L + LE ++ +L+ + +
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 1092 ERQ---HVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQAR 1148
E + ++ K++ + L+ ++ + E+ + L+ L++K + + + HE LQA+
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 1149 IKSLEKDSWRKASRSAA-------ESALKNEGLSSDEEFD 1181
I L+ +K A E A KN L E +
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1124
Score = 55.5 bits (132), Expect = 3e-07
Identities = 47/256 (18%), Positives = 107/256 (41%), Gaps = 25/256 (9%)
Query: 326 SSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKL 385
+ E+E + + +++ + L +A + EL ++ + ++++L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 386 EPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQV 445
E LE +LEE+ + + + + +A+Q + EL + + E R LE Q
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1801
Query: 446 MELQNKLKHVQGPEPAK-----EVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTAL 500
EL++KL ++G +K L + + E +E+ KQ + L+ ++++L +
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1861
Query: 501 KGALKEEVASRDQ--------------------EVEHVRQQYQRDTEQLRRSMQDATQDH 540
+++E +Q E E Q+ + +L+R + +AT+ +
Sbjct: 1862 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1921
Query: 541 AVLEAERQKMSALVRG 556
+ E + + +RG
Sbjct: 1922 EAMGREVNALKSKLRG 1937
Score = 37.7 bits (86), Expect = 0.066
Identities = 27/141 (19%), Positives = 69/141 (48%), Gaps = 13/141 (9%)
Query: 320 GILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEV 379
G ++ + ++ K++ + E+++ +TK++ + +K++E+ ++++E
Sbjct: 1813 GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLK---QKDKKLKEILLQVEDER 1869
Query: 380 KKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRH 439
K ++ + Q E+ +L+ LE + E+Q+ N + ++R LD+ +
Sbjct: 1870 KMAEQYK-------EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Query: 440 GLETQVMELQNKLKHVQGPEP 460
+ +V L++KL+ GP P
Sbjct: 1923 AMGREVNALKSKLR---GPPP 1940
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 271 bits (694), Expect = 2e-72
Identities = 243/908 (26%), Positives = 416/908 (45%), Gaps = 140/908 (15%)
Query: 368 VEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNM 427
+ EL+ +L +E K RQ+LE + LE + E+ + LQ + K + + +ELQ
Sbjct: 1036 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095
Query: 428 KRLLDQGEDLRHGLETQVMELQNKLKHVQGP-----------EPAKEVLLKDLLETRELL 476
LD ++ ++ EL+ + +Q E K L ++L + L
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155
Query: 477 EEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDA 536
E+ L+ +E RE+E+T LK AL EE S + +V+ +RQ++ + E+L ++
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1215
Query: 537 TQDHAVLEAERQ---KMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLR 593
+ A L+ +Q K +A + G R L + +E H K+ L A QEL
Sbjct: 1216 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH-------KKKKLEAQVQELQSKC 1268
Query: 594 MEKEEMEEELGEKIEVLQRELEQARASAGDT--------RQVEVLKKELLRTQE------ 639
+ E EL +K+ LQ E+E + + V L +L TQE
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1328
Query: 640 --------ELKELQAER---QSQEVAGRHRDRELEKQLAVLRVEADRGRE---------- 678
+L++L+ ER Q Q + LE+ ++ L ++ ++
Sbjct: 1329 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE 1388
Query: 679 -LEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRR 737
LEE + QK ++ L Q EE + A E L Q + L ++ +
Sbjct: 1389 ALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1448
Query: 738 RILGLEQQLKETRGL----VDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGS--- 790
+ +Q L E + + D + EA R+K + + + LEEAL A +E E +
Sbjct: 1449 KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1508
Query: 791 ---------------------LAAAKRALEARLEEAQRGLARLGQEQQTLNRA---LEE- 825
L +KRALE ++EE + L L E Q A LE
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568
Query: 826 ----EGKQREVLRRGKAELEEQKRLLDRTVDRLNKELE---------------------- 859
+G+ L+ + EE++R L R + ELE
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 860 ---------KIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSR 910
K E++ + L++LQAQ++D++ RE+ DA+ + + A++
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQ----RELEDARASRDEIFATAKENEKKAKS 1684
Query: 911 LQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEK 970
L+ ++ +L++ L A++ R A L+KE LA+ L + QD++ R LE +
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELAS---SLSGRNALQDEKRR----LEAR 1737
Query: 971 VSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDL 1030
+++LE EL+EE+ +E ++DRV + Q +QL EL ERS Q E + LERQNK+L
Sbjct: 1738 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1797
Query: 1031 KTRLASSEGFQKP--SASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQ 1088
+++L EG K ++++ LE++ L+E+++ E REK + ++ ++K+KE+ +Q
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Query: 1089 IEDERQHVNDQKDQL---SLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQL 1145
+EDER+ K+Q + RVK LKRQ++EAEEE +R++ R+K QRE++E E NE +
Sbjct: 1858 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Query: 1146 QARIKSLE 1153
+ +L+
Sbjct: 1918 GREVNALK 1925
Score = 179 bits (454), Expect = 1e-44
Identities = 185/841 (21%), Positives = 382/841 (45%), Gaps = 92/841 (10%)
Query: 359 AGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQ----------LEEKTEECSRLQE 408
A + ++ +++ +L+ +L+EE RQKL+ +V E + ++++ + S+ ++
Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 409 LLERRKGE----AQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEV 464
LLE R + + ++ +N+ +L ++ E + LE + L+ + K Q E K
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE---VRLKKEEKSRQELEKLKRK 1059
Query: 465 LLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQR 524
L D + E + ++ ++ QL +E EL A L +E+A ++ ++ +R + +
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEG 1118
Query: 525 DTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDL-- 582
L+ + E +++ + + L+ ELE+T + T Q + K ++++
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 583 --RATKQELLQLRMEKEEMEEELGEKIEVLQRELEQ-ARASAGDTRQVEVLKKELLRTQE 639
+A +E + +EM ++ + +E L +LEQ RA A + + L+KE
Sbjct: 1179 LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAG 1238
Query: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE 699
EL+ L +Q E H+ ++LE Q+ L+ + G E +L + +L+ + E
Sbjct: 1239 ELRVLGQAKQEVE----HKKKKLEAQVQELQSKCSDG---ERARAELNDKVHKLQNEVES 1291
Query: 700 ASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAV 759
+ AE +A L + A++ + L++TQE E R+ L +
Sbjct: 1292 VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS---------------- 1335
Query: 760 EARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTL 819
KL++LE E+ L++ L+ E + +L L +L ++++ L + L
Sbjct: 1336 -----TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390
Query: 820 NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDY 879
+ K+ E L + E L++T +RL +EL+ + D +QL + LE
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ-RQLVSNLEKK 1449
Query: 880 KEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQAL-QASQAERDTARLDKEL 938
+ K + +A+ + + +A E ++ + + L +AL +A +A+ + R +K L
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 939 LAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQ 998
A E E+ S+DD + + LE+ LET+++E K Q
Sbjct: 1510 KA--------EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT--------------Q 1547
Query: 999 VDQLRTELMQERSARQDLECDKISLERQ-NKDLKTRLASSEGFQKPSASLSQLESQNQLL 1057
+++L EL A+ LE + +L+ Q +DL+ R +E ++ QL+ Q
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR------QLQRQLHEY 1601
Query: 1058 QERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEA 1117
+ L+ E +++ + + +KLE +K+L +Q + + +++ +++ L+ Q+ +
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK----GREEAIKQLRKLQAQMKDF 1657
Query: 1118 EEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSD 1177
+ E+E R + +E + + L+A + L++D +AAE A K L +
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED------LAAAERARKQADLEKE 1711
Query: 1178 E 1178
E
Sbjct: 1712 E 1712
Score = 178 bits (451), Expect = 3e-44
Identities = 213/960 (22%), Positives = 414/960 (43%), Gaps = 145/960 (15%)
Query: 343 KMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVK----KRQKLEPSQVGLERQLEE 398
K++PL+ V+ + A + EL +K +E Q+K + E+K K +L + L+ QL+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDEL-QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 399 KTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLET-------QVMELQNK 451
+TE + +E+ R + Q+ + L M+ L++ ED L+ Q+++L+ +
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958
Query: 452 LKHVQGPEPA----------------KEVLLKD-----LLETRELLEE--------VLEG 482
L+ + E+L+ D L + R+LLEE + E
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018
Query: 483 KQRVEEQLRLRERE---LTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQD 539
+++ + +L+ + ++ L+ LK+E SR QE+E ++++ + D + D
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 540 HAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKE------DLRATKQELLQLR 593
A L+ + K LQ L +E + +K +E DL+ R
Sbjct: 1078 IAELKMQLAKKE---EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 594 MEKEEMEEELGEKIEVLQRELE--------QARASAGDTRQVEVLKKEL----------- 634
+ E+ + +LGE++E L+ ELE Q A ++V VLKK L
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194
Query: 635 -------LRTQEELKELQAERQSQEVAGRHRDRE-LEKQLA----VLRVEADRGRELEEQ 682
+ EEL E Q E+ + A ++++ LEK+ A LRV +E+E +
Sbjct: 1195 QEMRQKHAQAVEELTE-QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 683 NLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGL 742
+L+ +Q+L+ C + +A+ + L +V L E + + + + + L
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 743 EQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARL 802
QL++T+ L+ + + KL++LE E+ L++ L+ E + +L L +L
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1373
Query: 803 EEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIG 862
++++ L + L + K+ E L + E L++T +RL +EL+ +
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433
Query: 863 EDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQAL 922
D +QL + LE + K + +A+ + + +A E ++ + + L +AL
Sbjct: 1434 VDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492
Query: 923 Q-ASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEE 981
+ A +A+ + R +K L A E E+ S+DD + + LE+ LET+++E
Sbjct: 1493 EEALEAKEELERTNKMLKA--------EMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544
Query: 982 KNTVELLTDRVNRGRD------------------------------------QVDQLRTE 1005
K +E L D + D Q+ + TE
Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1604
Query: 1006 LMQERSARQDLECDKISLERQNKDLKTRLASS-EGFQKPSASLSQLESQNQLLQERLQAE 1064
L ER R K LE KDL+ + S+ +G ++ L +L++Q + Q L+
Sbjct: 1605 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1664
Query: 1065 EREKTVLQSTNRKLERKVKELSIQI----------EDERQHVNDQKDQLSLRVKALKRQV 1114
+ + +T ++ E+K K L + E R+ + +K++L+ + +
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 1115 DEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAE--SALKNE 1172
+ ++E RL+ + + E+EE+ E + R++ + + + ++ A E +A KNE
Sbjct: 1725 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1784
Score = 136 bits (342), Expect = 1e-31
Identities = 165/682 (24%), Positives = 298/682 (43%), Gaps = 89/682 (13%)
Query: 545 AERQKMSALVRGLQRELEETSE-ETGHWQSMFQKNKEDLRATKQEL-LQLRMEKEEMEEE 602
A+RQ+ ++ +QR + W +F K K L+ T+QE +Q + ++ + +E
Sbjct: 807 AKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKE 866
Query: 603 LGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELK-ELQAERQSQEVAGRHRDRE 661
+K E +ELEQ + + +K LL+ Q + + EL AE + V + +E
Sbjct: 867 RQQKAENELKELEQKHSQLTE-------EKNLLQEQLQAETELYAEAEEMRVRLAAKKQE 919
Query: 662 LEKQL----AVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKA-------KMVAEAE 710
LE+ L A L E DRG++L+ + ++ + + L + EE A K+ AEA+
Sbjct: 920 LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 979
Query: 711 ATVLGQRRAAVETTLRETQEENDEFRRRILGL-------EQQLKETRGLVDGGEAVEARL 763
L ++ + +E RI L E++ K L + E++ + L
Sbjct: 980 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1039
Query: 764 RDKLQRLEAEKQQLEEALNASQEE-----------EGSLAAAKRALEARLEEAQRGLARL 812
+L++ E +Q+LE+ + + + +A K L + EE Q LARL
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099
Query: 813 GQEQQTLNRALE------------EEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEK 860
E N AL+ +E E R KA E+QKR L ++ L ELE
Sbjct: 1100 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA--EKQKRDLGEELEALKTELED 1157
Query: 861 IGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASE-AEKTSGGLSRLQDEIQRLR 919
DS Q+L+A+ E ++ + + R + E +K + + L +++++ +
Sbjct: 1158 T-LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1216
Query: 920 QALQASQAERDTARLDKELLAQRLQGL---EQEAENKKRSQDDRARQLKGLEEKVSRLET 976
+A + T + LA L+ L +QE E+KK K LE +V L++
Sbjct: 1217 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK----------KKLEAQVQELQS 1266
Query: 977 ELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLAS 1036
+ + + L D+V++ +++V+ + L + L D SL Q +D + L
Sbjct: 1267 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ-ELLQ 1325
Query: 1037 SEGFQK--PSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQ 1094
E QK S L QLE + LQ++L E K + LER + L+IQ+ D ++
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK-------QNLERHISTLNIQLSDSKK 1378
Query: 1095 HVND----------QKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQ 1144
+ D K + ++ L +Q +E ++L+ + + Q+E+++ +
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 1145 LQARIKSLEKDSWRKASRSAAE 1166
+ + +LEK RK + AE
Sbjct: 1439 QRQLVSNLEKKQ-RKFDQLLAE 1459
Score = 132 bits (331), Expect = 3e-30
Identities = 148/698 (21%), Positives = 294/698 (42%), Gaps = 55/698 (7%)
Query: 191 GQARGRTGRRTRMLPPE-QRKRSKSLDSRLPRDTFEERERQSTNHWTSSTKYDNHV---- 245
GQA+ + + L + Q +SK D R ++ + N S T N
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 246 --------GTSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPD 297
S Q +Q L L +R + L+ EE R S QD + ++ +
Sbjct: 1304 IKLAKDVASLSSQLQDTQEL--LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1361
Query: 298 LLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKA 357
L R S K + E E + ++++ + ++ + ++ K
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK---AAAYDKL 1418
Query: 358 VAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEA 417
+ L +++++L LD + + LE Q ++ L E+ S+ + +R + EA
Sbjct: 1419 EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1478
Query: 418 QQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKL-----------KHVQGPEPAKEVLL 466
++ + ++ R L++ + + LE L+ ++ K+V E +K L
Sbjct: 1479 REKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1538
Query: 467 KDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDT 526
+ E + LEE+ + Q E+ E + ALKG + ++ +RD++ E R+Q QR
Sbjct: 1539 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 527 EQLRRSMQDATQDHAVLEAERQKMSALVRGLQREL-------EETSEETGHWQSM---FQ 576
+ ++D + A+ A ++K+ ++ L+ + EE ++ Q+ FQ
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Query: 577 KNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQA-RASAGDTRQVEVLKKELL 635
+ ED RA++ E+ E E+ + L + LQ +L A RA + E L +EL
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 636 RTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQ 695
+ LQ E++ E + ELE++ + +DR R+ +Q QL L R
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 696 DCEEASKAKMVAEAEATVL--------GQRRAAVETTLRETQEENDEFRRRILGLEQQLK 747
++ A+ E + L G ++ ++T+ + + + ++ EQ+ +
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV---EQEAR 1835
Query: 748 ETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQR 807
E + + + +L++ L ++E E++ E+ Q E+G+ A + L+ +LEEA+
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQY--KEQAEKGN--ARVKQLKRQLEEAEE 1891
Query: 808 GLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKR 845
R+ ++ L R L+E + E + R L+ + R
Sbjct: 1892 ESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 123 bits (309), Expect = 9e-28
Identities = 169/796 (21%), Positives = 324/796 (40%), Gaps = 134/796 (16%)
Query: 311 VDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE 370
++ +K + L +++ E +R+ + + K S + + + + VEE
Sbjct: 1148 LEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207
Query: 371 LQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRL 430
L +L++ + + L+ ++ LE++ + E L + + + + ++ ++Q ++
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Query: 431 LDQGEDLRHGLETQVMELQNKLKHVQGP---------EPAKEV--LLKDLLETRELLEEV 479
GE R L +V +LQN+++ V G + AK+V L L +T+ELL+E
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1327
Query: 480 LEGKQRVEEQLRLRERELTALKGALKEEVASRD--------------------------- 512
K V +LR E E +L+ L EE+ ++
Sbjct: 1328 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387
Query: 513 -----------QEVEHVRQQYQRDT------EQLRRSMQDATQDHAV-LEAERQKMSALV 554
+E+E++ QQY+ E+ + +Q D V L+ +RQ +S L
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1447
Query: 555 RGLQRELEETSEETGHWQSMF--QKNKEDLRATKQELLQLRM-----EKEEMEEELGEKI 607
+ QR+ ++ E + S + ++++ + A ++E L + E E +EEL
Sbjct: 1448 KK-QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1506
Query: 608 EVLQRELEQARASAGDT----RQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELE 663
++L+ E+E +S D ++E K+ L EE+K E + + A LE
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566
Query: 664 KQLAVLRVEADRGREL-----EEQNLQLQKTLQQLRQDCEEASKAKMVA----------- 707
+ L+ + +R + EE+ QLQ+ L + + E+ K + +A
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1626
Query: 708 -----EAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEAR 762
+A++ + G+ A + LR+ Q + +F+R + E E
Sbjct: 1627 KDLELQADSAIKGREEAIKQ--LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684
Query: 763 LRDKLQRLEA--------------EKQQLEEALNASQEEEGSLAAAKRALEAR------- 801
L L +L+ EK++L E L +S +L KR LEAR
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 802 LEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEK- 860
LEE Q + + + + E+ + R + E ++ L+R L +L +
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804
Query: 861 ---IGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQR 917
+ K + L+A++ +E+ +E + Q K + +K L +++DE +
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1864
Query: 918 LRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETE 977
Q QAE+ AR+ K+L Q LE+ E +R +R +L+ E
Sbjct: 1865 AEQ--YKEQAEKGNARV-KQLKRQ----LEEAEEESQRINANR-----------RKLQRE 1906
Query: 978 LDEEKNTVELLTDRVN 993
LDE + E + VN
Sbjct: 1907 LDEATESNEAMGREVN 1922
Score = 122 bits (306), Expect = 2e-27
Identities = 146/689 (21%), Positives = 291/689 (42%), Gaps = 85/689 (12%)
Query: 317 TIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE----LQ 372
++ G+L E ++ + + V+ + ++Q + T+ R++EE LQ
Sbjct: 1291 SVTGMLNEAEGKA-IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 373 RKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLD 432
+LDEE++ +Q LE L QL + ++ +E + ++ KE++N+ + +
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409
Query: 433 QG-----------EDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLE 481
+ L+ L+ V++L N+ + V E + + L E + + + +
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469
Query: 482 GKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHA 541
+ R E + R +E + +L AL+E + +++ E+E + + + E L S D ++
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKNVH 1528
Query: 542 VLEAERQKMSALVRGLQRELEETSEE---TGHWQSMFQKNKEDLRATKQELLQLRMEKEE 598
LE ++ + + ++ +LEE +E T + + N + L+ + LQ R E+ E
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 599 MEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQE-ELKELQAERQSQEVAGRH 657
EK LQR+L + D R+ L + E +LK+L+ + S + GR
Sbjct: 1589 ------EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA-IKGRE 1641
Query: 658 RDRELEKQLAVLRVEA-DRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQ 716
E KQL L+ + D RELE+ + + E KAK + EA+ L +
Sbjct: 1642 ---EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK---ENEKKAKSL-EADLMQLQE 1694
Query: 717 RRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQ 776
AA E ++ E +E +E + G A L+ EK++
Sbjct: 1695 DLAAAERARKQADLEKEELA----------EELASSLSGRNA-----------LQDEKRR 1733
Query: 777 LEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRG 836
LE + +EE A+ R+ +A + +L E T ++ R+ L R
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1793
Query: 837 KAELEEQ--------KRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARR--- 885
EL + K T+ L ++ ++ E +Q ++ QA + K+K ++
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 886 ---EVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQR 942
+V D ++ A+ + +AEK + + +L+ +++ + Q A R
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR------------- 1900
Query: 943 LQGLEQEAENKKRSQDDRARQLKGLEEKV 971
+ L++E + S + R++ L+ K+
Sbjct: 1901 -RKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 94.4 bits (233), Expect = 6e-19
Identities = 88/404 (21%), Positives = 182/404 (45%), Gaps = 9/404 (2%)
Query: 741 GLEQQLKETRGL--VDGGEAVEARLRDKLQRLE-AEKQQLEEALNASQEEEGSLAAAKRA 797
G+ L+E R L D A +A R L R A++QQ A+ Q + +
Sbjct: 773 GVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNW 832
Query: 798 LEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKE 857
RL + L ++ ++++ + +E K +E ++ + EL+E ++ + + N
Sbjct: 833 QWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 892
Query: 858 LEKIGEDSK--QALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEI 915
E++ +++ ++++ +L K++ + + + + ++ ++ ++ ++
Sbjct: 893 QEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM 952
Query: 916 QRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLE 975
L + L+ +A R +L+K +++ LE E + +++ K LEE++S L
Sbjct: 953 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT 1012
Query: 976 TELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLA 1035
T L EE+ + LT N+ + +L L +E +RQ+LE K LE D ++A
Sbjct: 1013 TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA 1072
Query: 1036 SSEG-FQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQ 1094
+ + L++ E + Q RL E +K R+LE + +L ++ ER
Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1132
Query: 1095 HVN---DQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREV 1135
N QK L ++ALK ++++ + LR K ++EV
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEV 1176
Score = 67.8 bits (164), Expect = 6e-11
Identities = 59/280 (21%), Positives = 129/280 (46%), Gaps = 17/280 (6%)
Query: 917 RLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQL---KGLEEKVSR 973
+++ LQ ++ E + + EL Q+ + +Q+AEN+ + + + QL K L ++ +
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDEL--QKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 897
Query: 974 LETELDEEKNTVEL-LTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKT 1032
ETEL E + + L + + + ++ L +E Q L+ ++ + +Q DL+
Sbjct: 898 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 1033 RLASSEGF-QKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIED 1091
+L E QK E++ + L++ + + + L + LE ++ +L+ + +
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 1092 ERQ---HVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQAR 1148
E + ++ K++ + L+ ++ + E+ + L+ L++K + + + HE LQA+
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 1149 IKSLEKDSWRKASRSAA-------ESALKNEGLSSDEEFD 1181
I L+ +K A E A KN L E +
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1117
Score = 55.5 bits (132), Expect = 3e-07
Identities = 47/256 (18%), Positives = 107/256 (41%), Gaps = 25/256 (9%)
Query: 326 SSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKL 385
+ E+E + + +++ + L +A + EL ++ + ++++L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 386 EPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQV 445
E LE +LEE+ + + + + +A+Q + EL + + E R LE Q
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 446 MELQNKLKHVQGPEPAK-----EVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTAL 500
EL++KL ++G +K L + + E +E+ KQ + L+ ++++L +
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1854
Query: 501 KGALKEEVASRDQ--------------------EVEHVRQQYQRDTEQLRRSMQDATQDH 540
+++E +Q E E Q+ + +L+R + +AT+ +
Sbjct: 1855 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1914
Query: 541 AVLEAERQKMSALVRG 556
+ E + + +RG
Sbjct: 1915 EAMGREVNALKSKLRG 1930
Score = 37.7 bits (86), Expect = 0.066
Identities = 27/141 (19%), Positives = 69/141 (48%), Gaps = 13/141 (9%)
Query: 320 GILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEV 379
G ++ + ++ K++ + E+++ +TK++ + +K++E+ ++++E
Sbjct: 1806 GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLK---QKDKKLKEILLQVEDER 1862
Query: 380 KKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRH 439
K ++ + Q E+ +L+ LE + E+Q+ N + ++R LD+ +
Sbjct: 1863 KMAEQYK-------EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 440 GLETQVMELQNKLKHVQGPEP 460
+ +V L++KL+ GP P
Sbjct: 1916 AMGREVNALKSKLR---GPPP 1933
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 256 bits (654), Expect = 9e-68
Identities = 224/877 (25%), Positives = 423/877 (48%), Gaps = 86/877 (9%)
Query: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQ-------VGLERQLEEKTEECSRLQELLERRKG 415
EL ++ ELQ L+ E R K E + L+ +LE+ + + QEL +R+
Sbjct: 1108 ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQ 1167
Query: 416 EAQQSNKELQNMKRLLD-QGEDLRHGLETQVMELQNKLKHVQ----GPEPAKEVLLKDLL 470
E K L+ + + Q +++R V EL +L+ + E AK+ L +
Sbjct: 1168 EVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERG 1227
Query: 471 ETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLR 530
E ++ +L+GK E + + E +L +E+ + E E VR + +L+
Sbjct: 1228 ELANEVKVLLQGKGDSEHKRKKVEAQL--------QELQVKFNEGERVRTELADKVTKLQ 1279
Query: 531 RSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELL 590
+ + T + +++ K++ L+ +L++T E + Q+ + +L
Sbjct: 1280 VELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQE-------LLQEENRQKLSLSTKLK 1332
Query: 591 QLRMEKEEMEEELGEKIEV---LQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAE 647
Q+ EK E+L E+ E L++++ A D ++ L T EE+K + +
Sbjct: 1333 QVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKR-KLQ 1391
Query: 648 RQSQEVAGRHRDR------------ELEKQLAVLRVEADRGRE----LEEQNLQLQKTLQ 691
+ + ++ RH ++ L+++L L V+ D R+ LE++ + + L
Sbjct: 1392 KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLA 1451
Query: 692 QLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEE-------NDEFRRRILGLEQ 744
+ + + ++ + AEAEA + ++ L E E+ N +FR + L
Sbjct: 1452 EEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMS 1511
Query: 745 QLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEE----EGSLAAAK----R 796
+ V E + L +++ ++ + ++LE+ L A+++ E +L A K R
Sbjct: 1512 SKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER 1571
Query: 797 ALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNK 856
L+ R E+++ +L ++ + + LE+E KQR + + +LE + L+ +D NK
Sbjct: 1572 DLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANK 1631
Query: 857 ELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQ 916
+ ++ + L++LQAQ++D RE+ D + ++ ++A++ L ++ E+
Sbjct: 1632 NRD----EAIKQLRKLQAQMKD----CMRELDDTRASREEILAQAKENEKKLKSMEAEMI 1683
Query: 917 RLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLET 976
+L++ L A++ + A+ +++ LA E N + + LE ++++LE
Sbjct: 1684 QLQEELAAAERAKRQAQQERDELAD-------EIANSSGKGALALEEKRRLEARIAQLEE 1736
Query: 977 ELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLAS 1036
EL+EE+ EL+ DR+ + Q+DQ+ T+L ERS Q E + LERQNK+LK +L
Sbjct: 1737 ELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQE 1796
Query: 1037 SEGF--QKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQ 1094
EG K AS++ LE++ L+E+L E +E+ R+ E+K+K++ +Q++DER+
Sbjct: 1797 MEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERR 1856
Query: 1095 HV---NDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKS 1151
+ DQ D+ S R+K LKRQ++EAEEE +R + R+K QRE+E+ E + + + S
Sbjct: 1857 NAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSS 1916
Query: 1152 LEKDSWRKASRS---AAESALKNEGLSSDEEFDSVYD 1185
L K+ R+ A K G SDEE D D
Sbjct: 1917 L-KNKLRRGDLPFVVPRRMARKGAGDGSDEEVDGKAD 1952
Score = 187 bits (476), Expect = 4e-47
Identities = 206/928 (22%), Positives = 409/928 (44%), Gaps = 113/928 (12%)
Query: 343 KMQPLVMVSSGSTKAVAGQGELTRKVEE---LQRKLDEEVKKRQKLEPSQVGLERQLEEK 399
K++PL+ VS + +A + EL + E+ + +L E + +L ++ L+ QL+ +
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 400 TEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPE 459
TE C+ +EL R + Q+ E++ H LE +V E + + +H+Q
Sbjct: 893 TELCAEAEELRARLTAKKQEL--------------EEICHDLEARVEEEEERCQHLQA-- 936
Query: 460 PAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVR 519
K+ + +++ E E LEE +Q+++ + E +L L+ +E++ DQ + +
Sbjct: 937 -EKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLE---EEQIILEDQNCKLAK 992
Query: 520 QQ------------YQRDTEQLRRSMQDATQDHAVL-----------EAERQKMSALVRG 556
++ + E+ +S+ H + E +RQ++ R
Sbjct: 993 EKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRK 1052
Query: 557 LQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEME-----------EELGE 605
L+ + + S++ Q+ + K L A K+E LQ + + E E EL
Sbjct: 1053 LEGDSTDLSDQIAELQAQIAELKMQL-AKKEEELQAALARVEEEAAQKNMALKKIRELES 1111
Query: 606 KIEVLQRELEQARASAGDT-RQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEK 664
+I LQ +LE RAS +Q L +EL + EL++ +Q+ R++E+
Sbjct: 1112 QISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI 1171
Query: 665 QLAVLRVEA-DRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVET 723
L EA +++E + + +++L + E+ + K E L R +
Sbjct: 1172 LKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELAN 1231
Query: 724 TLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNA 783
++ + + + +E QL+E + + GE V L DK+ +L+ E + L+
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 784 SQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQ 843
S + L ALE++L++ Q L +++ +L+ L++ ++ R E EE
Sbjct: 1292 SDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEA 1351
Query: 844 KRLLDRTVDRLN---KELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASE 900
K L++ + L+ +++K EDS L+ E+ K K ++++ ++ ++ +
Sbjct: 1352 KHNLEKQIATLHAQVADMKKKMEDSVGCLE----TAEEVKRKLQKDLEGLSQRHEEKVAA 1407
Query: 901 AEKTSGGLSRLQDEIQRL-----RQALQASQAERDTARLDKELLAQRLQGLEQEAENKKR 955
+K +RLQ E+ L Q A E+ + D+ L ++ + E +
Sbjct: 1408 YDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRA 1467
Query: 956 SQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQD 1015
+ R ++ K L ++R E E+K +E R+N+ Q RTE+ S++ D
Sbjct: 1468 EAEAREKETKAL--SLARALEEAMEQKAELE----RLNK------QFRTEMEDLMSSKDD 1515
Query: 1016 -------LECDKISLERQNKDLKTRLASSEG-FQKPSASLSQLESQNQLLQERLQAEERE 1067
LE K +LE+Q +++KT+L E Q + +LE Q ++ + + + +
Sbjct: 1516 VGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQG 1575
Query: 1068 KTVLQSTNRK-LERKVKELSIQIEDERQHVN-----------DQKDQLSLRVKALKRQVD 1115
+ +K L R+V+E+ ++EDER+ + D KD L + + + D
Sbjct: 1576 RDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKD-LEAHIDSANKNRD 1634
Query: 1116 EAEEEIERLDGLRKKAQREVEEQHEVNEQLQA-------RIKSLEKDSWR-KASRSAAES 1167
EA +++ +L K RE+++ E++ A ++KS+E + + + +AAE
Sbjct: 1635 EAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAER 1694
Query: 1168 ALKNEGLSSDEEFDSVYDPSSIASLLTE 1195
A + DE D + + S +L E
Sbjct: 1695 AKRQAQQERDELADEIANSSGKGALALE 1722
Score = 135 bits (339), Expect = 3e-31
Identities = 155/652 (23%), Positives = 304/652 (46%), Gaps = 72/652 (11%)
Query: 545 AERQKMSALVRGLQRELEETSE-ETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEEL 603
A+RQ+ ++ LQR + W +F K K LLQ+ ++EEM +
Sbjct: 800 AKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKP--------LLQVSRQEEEMMAKE 851
Query: 604 GEKIEVLQRELE-QARASAGDTRQVEVLKKELLRTQEELK---ELQAERQSQEVAGRHRD 659
E ++V +++L + R + +T Q +++ E L+ QE+L+ EL AE + +
Sbjct: 852 EELVKVREKQLAAENRLTEMETLQSQLMA-EKLQLQEQLQAETELCAEAEELRARLTAKK 910
Query: 660 RELEKQL----AVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKA-------KMVAE 708
+ELE+ A + E +R + L+ + ++Q+ +Q+L + EE A K+ E
Sbjct: 911 QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE 970
Query: 709 AEATVLGQRRAAVETTLRETQEEND-------EFRRRILGLEQQLKETRGLVDGGEAVEA 761
A+ L + + +E + +E EF + E++ K L + EA+
Sbjct: 971 AKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMIT 1030
Query: 762 RLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNR 821
L ++L+R E ++Q+LE+ + + L+ L+A++ E + LA+ +E Q
Sbjct: 1031 DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALA 1090
Query: 822 ALEEEGKQREVLRRGKAELEEQKRLLDRTVD---RLNKELEKIGEDSKQALQQLQAQLED 878
+EEE Q+ + + ELE Q L ++ + EK D + L+ L+ +LED
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150
Query: 879 YKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKEL 938
+ AQ++ + S+ + E+ L++ L+ +A+ A++ +E+
Sbjct: 1151 TLDSTA-----AQQELR-------------SKREQEVNILKKTLE-EEAKTHEAQI-QEM 1190
Query: 939 LAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTD-------R 991
+ Q +E+ AE ++++ +A LE+ LE E E N V++L +
Sbjct: 1191 RQKHSQAVEELAEQLEQTKRVKA----NLEKAKQTLENERGELANEVKVLLQGKGDSEHK 1246
Query: 992 VNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQ--KPSASLSQ 1049
+ Q+ +L+ + + R +L DK++ + D T L S + K + S
Sbjct: 1247 RKKVEAQLQELQVKFNEGERVRTEL-ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA 1305
Query: 1050 LESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQ---LSLR 1106
LESQ Q QE LQ E R+K L + +++E + Q+E+E + ++ + Q L +
Sbjct: 1306 LESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQ 1365
Query: 1107 VKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWR 1158
V +K++++++ +E + +++K Q+++E + +E+ A LEK R
Sbjct: 1366 VADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTR 1417
Score = 67.8 bits (164), Expect = 6e-11
Identities = 63/278 (22%), Positives = 127/278 (45%), Gaps = 14/278 (5%)
Query: 311 VDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE 370
+D +A+ IL + + E+E ++ + +++ + L +A + EL ++
Sbjct: 1654 LDDTRASREEILAQ-AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIAN 1712
Query: 371 LQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRL 430
K ++++++LE LE +LEE+ + + L++ + Q N +L +
Sbjct: 1713 SSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSH 1772
Query: 431 LDQGEDLRHGLETQVMELQNKLKHVQGPEPAK-----EVLLKDLLETRELLEEVLEGKQR 485
+ E+ R LE Q EL+ KL+ ++G +K L + + E L+ + +Q
Sbjct: 1773 AQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQA 1832
Query: 486 VEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEA 545
+Q+R E++L + + +E + +Q + + R +QL+R +++A E
Sbjct: 1833 ACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTR-LKQLKRQLEEA-------EE 1884
Query: 546 ERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLR 583
E Q+ +A R LQRELE+ +E K LR
Sbjct: 1885 EAQRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922
Score = 66.6 bits (161), Expect = 1e-10
Identities = 93/428 (21%), Positives = 177/428 (41%), Gaps = 46/428 (10%)
Query: 279 EPRRSAQDPTMLQFKSTPDLLRDQQEAAPPG------SVDHMKATIYGILREGSSESETS 332
E + A + + + K+ + L D+ +A ++ MKA L+ +SE
Sbjct: 1524 EKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEK 1583
Query: 333 VRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGL 392
++ V V E L + AVA + +L +++L+ +D K R + L
Sbjct: 1584 KKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL 1643
Query: 393 ERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQ-------GEDLRHGLETQV 445
+ Q+++ E + E +A+++ K+L++M+ + Q E + + +
Sbjct: 1644 QAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQER 1703
Query: 446 MELQNKLKHVQGPE----PAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALK 501
EL +++ + G K L + + E LEE + + ++L+ ++ +
Sbjct: 1704 DELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQIN 1763
Query: 502 GALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDA--------TQDHAVLEA-------- 545
L E S Q+ E+ RQQ +R ++L+ +Q+ LEA
Sbjct: 1764 TDLNLE-RSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQ 1822
Query: 546 ------ERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEM 599
ERQ VR +++L++ + + ++ K+ L QL+ + EE
Sbjct: 1823 LDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEA 1882
Query: 600 EEE---LGEKIEVLQRELEQARASA-GDTRQVEVLKKELLRTQEELKELQAERQSQEVAG 655
EEE LQRELE A +A R+V LK +L R +L + R +++ AG
Sbjct: 1883 EEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR--GDLPFVVPRRMARKGAG 1940
Query: 656 RHRDRELE 663
D E++
Sbjct: 1941 DGSDEEVD 1948
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 244 bits (622), Expect = 5e-64
Identities = 246/950 (25%), Positives = 433/950 (45%), Gaps = 137/950 (14%)
Query: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 422
E + + E + K+ K R K E + +E +L ++ + L++L R GE+ + +
Sbjct: 1035 EFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE 1094
Query: 423 ELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLE- 481
++ ++ + E+LR L + ELQ L + A+ LLK L E + L E E
Sbjct: 1095 QMVEQQQ---RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1151
Query: 482 ------GKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQD 535
+ + E+Q R EL AL+G L++ + S + + E +R + +++ +L++++++
Sbjct: 1152 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE-LRSKREQEVTELKKTLEE 1210
Query: 536 ATQDH-AVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRM 594
T+ H A ++ RQ+ + L +LE+ G W+ + ++ + EL L+
Sbjct: 1211 ETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQT 1270
Query: 595 EKEEMEE------------------------ELGEKIEVLQRELEQARASAGDTRQVEV- 629
++E E+ E EK++ Q ELE + + +
Sbjct: 1271 ARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIR 1330
Query: 630 LKKELLRTQEEL---KELQAERQSQEVAGRHRDRELEKQLAVLRVEADR--------GRE 678
L KEL T+ +L +EL E ++A R R +E + A LR + + GRE
Sbjct: 1331 LSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRE 1390
Query: 679 LEEQNLQLQKTLQQLRQDC---EEASKAKMVAEAEATVLGQRRAAVETTL-------RET 728
L+ QL + ++ ++ E +A+ A EA L QR A T+ R
Sbjct: 1391 LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRL 1450
Query: 729 QEENDEF-------RRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLE--- 778
Q+E D+ R+ + LE++ ++ L+ +A R ++ +R EAE ++ E
Sbjct: 1451 QQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARA 1510
Query: 779 ----EALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLR 834
AL QE L RAL A LE +G+ L RA + LR
Sbjct: 1511 LSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLR 1570
Query: 835 RGKAELE-------EQKRLLDRTVDRLNKELEK-------IGEDSKQAL--QQLQAQLED 878
ELE + K L+ TV L + E+ GE+ ++ L Q A++E
Sbjct: 1571 AQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVER 1630
Query: 879 YKEKARREVADAQRQAKDWASE---AEKTSGG---------LSRLQDEIQRLRQALQASQ 926
+E+ +R +A A R+ + E A+ S G L ++Q +++ L + ++ ++
Sbjct: 1631 DEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR 1690
Query: 927 AERDTARLDKELLAQRLQGLEQEA-----------ENKKRSQDDR--------------- 960
R+ +RL+GLE E ++++Q DR
Sbjct: 1691 TSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKA 1750
Query: 961 --ARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLEC 1018
+ + LE ++ +LE EL+EE++ ELL DR + QV+ L TEL ERS E
Sbjct: 1751 AILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAES 1810
Query: 1019 DKISLERQNKDLKTRLASSEGFQKP--SASLSQLESQNQLLQERLQAEEREKTVLQSTNR 1076
+ LERQ ++L+ RL + + +++ LES+ +E+L+ E RE+ + R
Sbjct: 1811 GRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1870
Query: 1077 KLERKVKELSIQIEDERQHVNDQKDQL---SLRVKALKRQVDEAEEEIERLDGLRKKAQR 1133
+ E+++KE+ +Q+E+ER+ + +DQL +LRVK LKRQ++EAEEE R R++ QR
Sbjct: 1871 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1930
Query: 1134 EVEEQHEVNEQLQARIKSLEKDSWRK----ASRSAAESALKNEGLSSDEE 1179
E+E+ E E + + +L R +R+ + EG++SDEE
Sbjct: 1931 ELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEE 1980
Score = 172 bits (436), Expect = 2e-42
Identities = 225/943 (23%), Positives = 403/943 (42%), Gaps = 142/943 (15%)
Query: 343 KMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQ----KLEPSQVGLERQLEE 398
K++PL+ V+ A EL +KV+ELQ++ EV + Q +LE + L QL
Sbjct: 865 KVKPLLQVTRQDEVLQARAQEL-QKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRA 923
Query: 399 KTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLK----H 454
+ E C+ +E R Q+ + ++ + + E+ ++T+ LQ ++ H
Sbjct: 924 EAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAH 983
Query: 455 VQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQE 514
++ E A++ L + + T +++ E +E+Q +E L+ L E + +E
Sbjct: 984 LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE 1043
Query: 515 VEHVRQ--QYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQ 572
E V+ + + E M+D + E RQ++ L R L E E E+
Sbjct: 1044 EEKVKSLNKLRLKYEATIADMEDRLRKE---EKGRQELEKLKRRLDGESSELQEQ----- 1095
Query: 573 SMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKK 632
+++ + EE+ +LG K E LQ L +A G Q L K
Sbjct: 1096 ----------------MVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQ---LLK 1136
Query: 633 ELLRTQEELKELQAERQSQEVA---GRHRDRELEKQLAVLRVE-------ADRGREL--- 679
L Q L E Q + +S+ VA + R+L ++L LR E + +EL
Sbjct: 1137 SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSK 1196
Query: 680 -EEQNLQLQKTL-----------QQLRQDCEEA------------------SKAKMVAEA 709
E++ +L+KTL Q+LRQ +A K ++ EA
Sbjct: 1197 REQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEA 1256
Query: 710 EATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQR 769
E + L ++++T ++E ++ RRR LE QL+E +G GE A +KLQR
Sbjct: 1257 EVSELRAELSSLQT----ARQEGEQRRRR---LELQLQEVQGRAGDGERARAEAAEKLQR 1309
Query: 770 LEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQ-------RGLARLGQ-------E 815
+AE + + ALN ++ + L+ + EA+L +AQ R LG E
Sbjct: 1310 AQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAE 1369
Query: 816 QQTLNRALEEEGKQRE----VLRRGKAELEEQKRLLDRTVDRL--NKELEKIGEDSKQAL 869
L LEEE RE L+ +A+L E +R + L +E + +AL
Sbjct: 1370 AAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1429
Query: 870 QQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQA-- 927
Q A+ + ++ R Q++ D + E+ +S L+ + ++ Q L +A
Sbjct: 1430 TQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV 1489
Query: 928 -----ERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEK 982
ER+ A + R L + E ++ ++++ RQ + L ++ L + D+
Sbjct: 1490 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVG 1549
Query: 983 NTVELL-------TDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQN-KDLKTRL 1034
+V L N R QV +L EL A+ LE +L+ Q+ +DL+ R
Sbjct: 1550 KSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRD 1609
Query: 1035 ASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQ 1094
+ E ++ QL Q + + E +++T+ + +KLE +++EL Q+ Q
Sbjct: 1610 EAGEERRR------QLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ 1663
Query: 1095 HVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEK 1154
K++ +++ ++ Q+ E E+E + + EE N + + R+K LE
Sbjct: 1664 ----GKEEAVKQLRKMQAQMKELWREVE-------ETRTSREEIFSQNRESEKRLKGLEA 1712
Query: 1155 DSWR-KASRSAAESALKNEGLSSDEEFDSVYDPS-SIASLLTE 1195
+ R + +A++ A + DE D V + + S A++L E
Sbjct: 1713 EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEE 1755
Score = 118 bits (296), Expect = 3e-26
Identities = 159/665 (23%), Positives = 289/665 (43%), Gaps = 91/665 (13%)
Query: 318 IYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE----LQR 373
+ G L E S++ + +++S ++ + T+A G R +E L+
Sbjct: 1317 VSGALNEAESKT-IRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1375
Query: 374 KLDEEVKKRQK----LEPSQVGLERQLEEKTEECSRLQ---ELLERRKGEAQQSNKELQN 426
+L+EE R++ L+ +Q L + EE L+ E R EA+ + L
Sbjct: 1376 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAE 1435
Query: 427 MKRLLDQGE----DLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEG 482
+D+ E L+ L+ M+L+ + + V E + + L E + + +E
Sbjct: 1436 KTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1495
Query: 483 KQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAV 542
++R E + R RE +L AL+EE +R +E+E + + + E L S D +
Sbjct: 1496 RERAEAEGREREARALSLTRALEEEQEAR-EELERQNRALRAELEALLSSKDDVGKSVHE 1554
Query: 543 LEAERQKMSALVRGLQRELEETSEE-------------------TGHWQSMFQKNKEDLR 583
LE + L+ ++ E +E T H + + +++
Sbjct: 1555 LERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEE 1614
Query: 584 ATKQELLQLRMEKEEMEEE---------LGEKIEVLQRELEQARASAGDTRQVEVLKKEL 634
+Q QLR + E +EE +K+E EL+ ASAG ++ V K+L
Sbjct: 1615 RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAV--KQL 1672
Query: 635 LRTQEELKELQAERQSQEVAGRH---RDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQ 691
+ Q ++KEL E + + ++RE EK+L L E R L+E+ + +
Sbjct: 1673 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLR---LQEELAASDRARR 1729
Query: 692 QLRQDCEE---------ASKAKMVAEAEATV--LGQRRAAVETTLRETQEENDEFRRRIL 740
Q +QD +E SKA ++ E LGQ +E ++ ND +R+ +L
Sbjct: 1730 QAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLL 1789
Query: 741 GLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAK---RA 797
+E E + + A+ Q+LE + Q+L L +E+ G+ A K A
Sbjct: 1790 QVESLTTE----LSAERSFSAKAESGRQQLERQIQELRGRL--GEEDAGARARHKMTIAA 1843
Query: 798 LEARLEEAQRGLARLGQEQQTLNRALEEEGKQR--EVLRRGKAELEEQKRLLDRTVDRLN 855
LE++L +A+ L EQ+T R L + +R + L+ ++EE++R+ D+ D+L
Sbjct: 1844 LESKLAQAEEQL-----EQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLE 1898
Query: 856 KELEKIGEDSKQALQQLQAQLEDYKEKARREVAD---AQRQAKDWASEAEKTSGGLSRLQ 912
K ++QL+ QLE+ +E+A R A QR+ +D AE + ++ L+
Sbjct: 1899 K--------GNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLR 1950
Query: 913 DEIQR 917
+ ++R
Sbjct: 1951 NRLRR 1955
Score = 111 bits (277), Expect = 5e-24
Identities = 151/611 (24%), Positives = 266/611 (43%), Gaps = 78/611 (12%)
Query: 246 GTSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPT------MLQFKSTPDLL 299
G Q AQ+Q LS + R ++ + L++ EE RR A + + T D L
Sbjct: 1388 GRELQTAQAQ----LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1443
Query: 300 ----RDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGST 355
R Q+ ++D + R+ S E R+ L+ E+ ++
Sbjct: 1444 ERGRRRLQQELDDATMDLEQQ------RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERE 1497
Query: 356 KAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKG 415
+A A E + L R L+EE + R++LE L +L E L K
Sbjct: 1498 RAEAEGREREARALSLTRALEEEQEAREELERQNRALRAEL-----------EALLSSKD 1546
Query: 416 EAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETREL 475
+ +S EL+ R+ +Q + L QV EL+++L + + EV ++ L+T+
Sbjct: 1547 DVGKSVHELERACRVAEQA---ANDLRAQVTELEDELTAAEDAKLRLEVTVQ-ALKTQH- 1601
Query: 476 LEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEH------VRQQYQRDTEQL 529
E L+G+ E+ R R+L L++ RD+E + R++ + + E+L
Sbjct: 1602 -ERDLQGRDEAGEE---RRRQLAK---QLRDAEVERDEERKQRTLAVAARKKLEGELEEL 1654
Query: 530 RRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQEL 589
+ M A Q + +KM A ++ L RE+EET S +++++ L+ + E+
Sbjct: 1655 KAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEV 1714
Query: 590 LQL----------RMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQE 639
L+L R + ++ +E+ + EV L +A A + RQ+E L + +E
Sbjct: 1715 LRLQEELAASDRARRQAQQDRDEMAD--EVANGNLSKA-AILEEKRQLE---GRLGQLEE 1768
Query: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADR--GRELEEQNLQLQKTLQQLR--- 694
EL+E Q+ S+ + R+R L+ + + A+R + E QL++ +Q+LR
Sbjct: 1769 ELEEEQS--NSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1826
Query: 695 --QDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGL 752
+D ++ KM A + L Q +E RE RR E++LKE
Sbjct: 1827 GEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRR----AEKRLKEVVLQ 1882
Query: 753 VDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARL 812
V+ V +LRD+L++ +QL+ L ++EE A +R L+ LE+ +
Sbjct: 1883 VEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESM 1942
Query: 813 GQEQQTLNRAL 823
+E TL L
Sbjct: 1943 NREVTTLRNRL 1953
Score = 82.4 bits (202), Expect = 2e-15
Identities = 110/473 (23%), Positives = 214/473 (45%), Gaps = 60/473 (12%)
Query: 741 GLEQQLKETRGL--VDGGEAVEARLRDKLQRLEAEK-QQLEEALNASQEEEGSLAAAKRA 797
G+ QL+E R L D + +A R L R +K QQ + AL Q + +
Sbjct: 798 GVLAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHW 857
Query: 798 LEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKE 857
RL + L ++ ++ + L +E K +E+ ++ E+ E L V +L +E
Sbjct: 858 QWWRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGE----LQGRVAQLEEE 913
Query: 858 LEKIGEDSKQALQQLQAQLEDYK-----EKARREVADAQRQAKDWASEAEKTSGGLS--- 909
++ E + A +L A+ E+ + K E+ ++ +A+ E E+ S +
Sbjct: 914 RARLAEQLR-AEAELCAEAEETRGRLAARKQELELVVSELEAR--VGEEEECSRQMQTEK 970
Query: 910 -RLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLE 968
RLQ IQ L L+A + R +L+K +++ E++ + +++ K LE
Sbjct: 971 KRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLE 1030
Query: 969 EKVSRLETELDEEKNTVELLT--------------DRV---NRGRDQVDQLRTEL----- 1006
++++ ++ EE+ V+ L DR+ +GR ++++L+ L
Sbjct: 1031 DRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS 1090
Query: 1007 -MQERSARQDLECDKI--SLERQNKDLKTRL--ASSEGFQKPSASLSQLESQNQL--LQE 1059
+QE+ Q +++ L R+ ++L+ L A EG + S E+Q L QE
Sbjct: 1091 ELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQE 1150
Query: 1060 RLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEE 1119
L++E +T + R L +++ L ++ED N Q++ S R +++V E ++
Sbjct: 1151 DLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKR----EQEVTELKK 1206
Query: 1120 EIERLDGLRKKAQREVEEQH-----EVNEQLQARIKSLEKDSWRKASRSAAES 1167
+E + + A +E+ ++H E+ EQL+ + K +W K +R A E+
Sbjct: 1207 TLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG--KGAWEK-TRLALEA 1256
Score = 75.5 bits (184), Expect = 3e-13
Identities = 103/429 (24%), Positives = 195/429 (45%), Gaps = 56/429 (13%)
Query: 750 RGLVDGGEAVEARLR-----DKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEE 804
+G +DG +A E ++ L R+ K + A EEE L + +
Sbjct: 763 KGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTD--IIVSFQA 820
Query: 805 AQRG-LARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGE 863
A RG LAR RA ++ +Q+ LR + +L RL +++ + +
Sbjct: 821 AARGYLAR---------RAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQ 871
Query: 864 DSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQ 923
++Q + LQA+ ++ ++ V + Q+Q+ A E + G +++L++E RL + L+
Sbjct: 872 VTRQD-EVLQARAQELQK-----VQELQQQS---AREVGELQGRVAQLEEERARLAEQLR 922
Query: 924 ASQAERDTARLDKELLAQRLQGLE---QEAENKKRSQDDRARQL----KGLEEKVSRLET 976
A A + LA R Q LE E E + +++ +RQ+ K L++ + LE
Sbjct: 923 AEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEA 982
Query: 977 ELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDL--ECDKISLERQNKDLKTRL 1034
L+ E+ + L Q++++ TE ++ L E L ++ K L+ RL
Sbjct: 983 HLEAEEGARQKL---------QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1033
Query: 1035 A--SSEGFQKPSA--SLSQLESQNQL----LQERLQAEEREKTVLQSTNRKLERKVKELS 1086
A SS+ ++ SL++L + + +++RL+ EE+ + L+ R+L+ + EL
Sbjct: 1034 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1093
Query: 1087 IQIEDERQHVNDQKDQLSLRVK----ALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVN 1142
Q+ +++Q + + QL + + AL R DE + L LR+ E Q ++
Sbjct: 1094 EQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLE 1153
Query: 1143 EQLQARIKS 1151
+ AR K+
Sbjct: 1154 SERVARTKA 1162
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 244 bits (622), Expect = 5e-64
Identities = 246/950 (25%), Positives = 433/950 (45%), Gaps = 137/950 (14%)
Query: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 422
E + + E + K+ K R K E + +E +L ++ + L++L R GE+ + +
Sbjct: 1027 EFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE 1086
Query: 423 ELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLE- 481
++ ++ + E+LR L + ELQ L + A+ LLK L E + L E E
Sbjct: 1087 QMVEQQQ---RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1143
Query: 482 ------GKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQD 535
+ + E+Q R EL AL+G L++ + S + + E +R + +++ +L++++++
Sbjct: 1144 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE-LRSKREQEVTELKKTLEE 1202
Query: 536 ATQDH-AVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRM 594
T+ H A ++ RQ+ + L +LE+ G W+ + ++ + EL L+
Sbjct: 1203 ETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQT 1262
Query: 595 EKEEMEE------------------------ELGEKIEVLQRELEQARASAGDTRQVEV- 629
++E E+ E EK++ Q ELE + + +
Sbjct: 1263 ARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIR 1322
Query: 630 LKKELLRTQEEL---KELQAERQSQEVAGRHRDRELEKQLAVLRVEADR--------GRE 678
L KEL T+ +L +EL E ++A R R +E + A LR + + GRE
Sbjct: 1323 LSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRE 1382
Query: 679 LEEQNLQLQKTLQQLRQDC---EEASKAKMVAEAEATVLGQRRAAVETTL-------RET 728
L+ QL + ++ ++ E +A+ A EA L QR A T+ R
Sbjct: 1383 LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRL 1442
Query: 729 QEENDEF-------RRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLE--- 778
Q+E D+ R+ + LE++ ++ L+ +A R ++ +R EAE ++ E
Sbjct: 1443 QQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARA 1502
Query: 779 ----EALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLR 834
AL QE L RAL A LE +G+ L RA + LR
Sbjct: 1503 LSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLR 1562
Query: 835 RGKAELE-------EQKRLLDRTVDRLNKELEK-------IGEDSKQAL--QQLQAQLED 878
ELE + K L+ TV L + E+ GE+ ++ L Q A++E
Sbjct: 1563 AQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVER 1622
Query: 879 YKEKARREVADAQRQAKDWASE---AEKTSGG---------LSRLQDEIQRLRQALQASQ 926
+E+ +R +A A R+ + E A+ S G L ++Q +++ L + ++ ++
Sbjct: 1623 DEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR 1682
Query: 927 AERDTARLDKELLAQRLQGLEQEA-----------ENKKRSQDDR--------------- 960
R+ +RL+GLE E ++++Q DR
Sbjct: 1683 TSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKA 1742
Query: 961 --ARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLEC 1018
+ + LE ++ +LE EL+EE++ ELL DR + QV+ L TEL ERS E
Sbjct: 1743 AILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAES 1802
Query: 1019 DKISLERQNKDLKTRLASSEGFQKP--SASLSQLESQNQLLQERLQAEEREKTVLQSTNR 1076
+ LERQ ++L+ RL + + +++ LES+ +E+L+ E RE+ + R
Sbjct: 1803 GRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1862
Query: 1077 KLERKVKELSIQIEDERQHVNDQKDQL---SLRVKALKRQVDEAEEEIERLDGLRKKAQR 1133
+ E+++KE+ +Q+E+ER+ + +DQL +LRVK LKRQ++EAEEE R R++ QR
Sbjct: 1863 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1922
Query: 1134 EVEEQHEVNEQLQARIKSLEKDSWRK----ASRSAAESALKNEGLSSDEE 1179
E+E+ E E + + +L R +R+ + EG++SDEE
Sbjct: 1923 ELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEE 1972
Score = 172 bits (436), Expect = 2e-42
Identities = 225/943 (23%), Positives = 403/943 (42%), Gaps = 142/943 (15%)
Query: 343 KMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQ----KLEPSQVGLERQLEE 398
K++PL+ V+ A EL +KV+ELQ++ EV + Q +LE + L QL
Sbjct: 857 KVKPLLQVTRQDEVLQARAQEL-QKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRA 915
Query: 399 KTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLK----H 454
+ E C+ +E R Q+ + ++ + + E+ ++T+ LQ ++ H
Sbjct: 916 EAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAH 975
Query: 455 VQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQE 514
++ E A++ L + + T +++ E +E+Q +E L+ L E + +E
Sbjct: 976 LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE 1035
Query: 515 VEHVRQ--QYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQ 572
E V+ + + E M+D + E RQ++ L R L E E E+
Sbjct: 1036 EEKVKSLNKLRLKYEATIADMEDRLRKE---EKGRQELEKLKRRLDGESSELQEQ----- 1087
Query: 573 SMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKK 632
+++ + EE+ +LG K E LQ L +A G Q L K
Sbjct: 1088 ----------------MVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQ---LLK 1128
Query: 633 ELLRTQEELKELQAERQSQEVA---GRHRDRELEKQLAVLRVE-------ADRGREL--- 679
L Q L E Q + +S+ VA + R+L ++L LR E + +EL
Sbjct: 1129 SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSK 1188
Query: 680 -EEQNLQLQKTL-----------QQLRQDCEEA------------------SKAKMVAEA 709
E++ +L+KTL Q+LRQ +A K ++ EA
Sbjct: 1189 REQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEA 1248
Query: 710 EATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQR 769
E + L ++++T ++E ++ RRR LE QL+E +G GE A +KLQR
Sbjct: 1249 EVSELRAELSSLQT----ARQEGEQRRRR---LELQLQEVQGRAGDGERARAEAAEKLQR 1301
Query: 770 LEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQ-------RGLARLGQ-------E 815
+AE + + ALN ++ + L+ + EA+L +AQ R LG E
Sbjct: 1302 AQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAE 1361
Query: 816 QQTLNRALEEEGKQRE----VLRRGKAELEEQKRLLDRTVDRL--NKELEKIGEDSKQAL 869
L LEEE RE L+ +A+L E +R + L +E + +AL
Sbjct: 1362 AAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1421
Query: 870 QQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQA-- 927
Q A+ + ++ R Q++ D + E+ +S L+ + ++ Q L +A
Sbjct: 1422 TQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV 1481
Query: 928 -----ERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEK 982
ER+ A + R L + E ++ ++++ RQ + L ++ L + D+
Sbjct: 1482 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVG 1541
Query: 983 NTVELL-------TDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQN-KDLKTRL 1034
+V L N R QV +L EL A+ LE +L+ Q+ +DL+ R
Sbjct: 1542 KSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRD 1601
Query: 1035 ASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQ 1094
+ E ++ QL Q + + E +++T+ + +KLE +++EL Q+ Q
Sbjct: 1602 EAGEERRR------QLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ 1655
Query: 1095 HVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEK 1154
K++ +++ ++ Q+ E E+E + + EE N + + R+K LE
Sbjct: 1656 ----GKEEAVKQLRKMQAQMKELWREVE-------ETRTSREEIFSQNRESEKRLKGLEA 1704
Query: 1155 DSWR-KASRSAAESALKNEGLSSDEEFDSVYDPS-SIASLLTE 1195
+ R + +A++ A + DE D V + + S A++L E
Sbjct: 1705 EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEE 1747
Score = 118 bits (296), Expect = 3e-26
Identities = 159/665 (23%), Positives = 289/665 (43%), Gaps = 91/665 (13%)
Query: 318 IYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE----LQR 373
+ G L E S++ + +++S ++ + T+A G R +E L+
Sbjct: 1309 VSGALNEAESKT-IRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1367
Query: 374 KLDEEVKKRQK----LEPSQVGLERQLEEKTEECSRLQ---ELLERRKGEAQQSNKELQN 426
+L+EE R++ L+ +Q L + EE L+ E R EA+ + L
Sbjct: 1368 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAE 1427
Query: 427 MKRLLDQGE----DLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEG 482
+D+ E L+ L+ M+L+ + + V E + + L E + + +E
Sbjct: 1428 KTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1487
Query: 483 KQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAV 542
++R E + R RE +L AL+EE +R +E+E + + + E L S D +
Sbjct: 1488 RERAEAEGREREARALSLTRALEEEQEAR-EELERQNRALRAELEALLSSKDDVGKSVHE 1546
Query: 543 LEAERQKMSALVRGLQRELEETSEE-------------------TGHWQSMFQKNKEDLR 583
LE + L+ ++ E +E T H + + +++
Sbjct: 1547 LERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEE 1606
Query: 584 ATKQELLQLRMEKEEMEEE---------LGEKIEVLQRELEQARASAGDTRQVEVLKKEL 634
+Q QLR + E +EE +K+E EL+ ASAG ++ V K+L
Sbjct: 1607 RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAV--KQL 1664
Query: 635 LRTQEELKELQAERQSQEVAGRH---RDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQ 691
+ Q ++KEL E + + ++RE EK+L L E R L+E+ + +
Sbjct: 1665 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLR---LQEELAASDRARR 1721
Query: 692 QLRQDCEE---------ASKAKMVAEAEATV--LGQRRAAVETTLRETQEENDEFRRRIL 740
Q +QD +E SKA ++ E LGQ +E ++ ND +R+ +L
Sbjct: 1722 QAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLL 1781
Query: 741 GLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAK---RA 797
+E E + + A+ Q+LE + Q+L L +E+ G+ A K A
Sbjct: 1782 QVESLTTE----LSAERSFSAKAESGRQQLERQIQELRGRL--GEEDAGARARHKMTIAA 1835
Query: 798 LEARLEEAQRGLARLGQEQQTLNRALEEEGKQR--EVLRRGKAELEEQKRLLDRTVDRLN 855
LE++L +A+ L EQ+T R L + +R + L+ ++EE++R+ D+ D+L
Sbjct: 1836 LESKLAQAEEQL-----EQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLE 1890
Query: 856 KELEKIGEDSKQALQQLQAQLEDYKEKARREVAD---AQRQAKDWASEAEKTSGGLSRLQ 912
K ++QL+ QLE+ +E+A R A QR+ +D AE + ++ L+
Sbjct: 1891 K--------GNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLR 1942
Query: 913 DEIQR 917
+ ++R
Sbjct: 1943 NRLRR 1947
Score = 111 bits (277), Expect = 5e-24
Identities = 151/611 (24%), Positives = 266/611 (43%), Gaps = 78/611 (12%)
Query: 246 GTSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPT------MLQFKSTPDLL 299
G Q AQ+Q LS + R ++ + L++ EE RR A + + T D L
Sbjct: 1380 GRELQTAQAQ----LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1435
Query: 300 ----RDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGST 355
R Q+ ++D + R+ S E R+ L+ E+ ++
Sbjct: 1436 ERGRRRLQQELDDATMDLEQQ------RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERE 1489
Query: 356 KAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKG 415
+A A E + L R L+EE + R++LE L +L E L K
Sbjct: 1490 RAEAEGREREARALSLTRALEEEQEAREELERQNRALRAEL-----------EALLSSKD 1538
Query: 416 EAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETREL 475
+ +S EL+ R+ +Q + L QV EL+++L + + EV ++ L+T+
Sbjct: 1539 DVGKSVHELERACRVAEQA---ANDLRAQVTELEDELTAAEDAKLRLEVTVQ-ALKTQH- 1593
Query: 476 LEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEH------VRQQYQRDTEQL 529
E L+G+ E+ R R+L L++ RD+E + R++ + + E+L
Sbjct: 1594 -ERDLQGRDEAGEE---RRRQLAK---QLRDAEVERDEERKQRTLAVAARKKLEGELEEL 1646
Query: 530 RRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQEL 589
+ M A Q + +KM A ++ L RE+EET S +++++ L+ + E+
Sbjct: 1647 KAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEV 1706
Query: 590 LQL----------RMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQE 639
L+L R + ++ +E+ + EV L +A A + RQ+E L + +E
Sbjct: 1707 LRLQEELAASDRARRQAQQDRDEMAD--EVANGNLSKA-AILEEKRQLE---GRLGQLEE 1760
Query: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADR--GRELEEQNLQLQKTLQQLR--- 694
EL+E Q+ S+ + R+R L+ + + A+R + E QL++ +Q+LR
Sbjct: 1761 ELEEEQS--NSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1818
Query: 695 --QDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGL 752
+D ++ KM A + L Q +E RE RR E++LKE
Sbjct: 1819 GEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRR----AEKRLKEVVLQ 1874
Query: 753 VDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARL 812
V+ V +LRD+L++ +QL+ L ++EE A +R L+ LE+ +
Sbjct: 1875 VEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESM 1934
Query: 813 GQEQQTLNRAL 823
+E TL L
Sbjct: 1935 NREVTTLRNRL 1945
Score = 82.4 bits (202), Expect = 2e-15
Identities = 110/473 (23%), Positives = 214/473 (45%), Gaps = 60/473 (12%)
Query: 741 GLEQQLKETRGL--VDGGEAVEARLRDKLQRLEAEK-QQLEEALNASQEEEGSLAAAKRA 797
G+ QL+E R L D + +A R L R +K QQ + AL Q + +
Sbjct: 790 GVLAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHW 849
Query: 798 LEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKE 857
RL + L ++ ++ + L +E K +E+ ++ E+ E L V +L +E
Sbjct: 850 QWWRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGE----LQGRVAQLEEE 905
Query: 858 LEKIGEDSKQALQQLQAQLEDYK-----EKARREVADAQRQAKDWASEAEKTSGGLS--- 909
++ E + A +L A+ E+ + K E+ ++ +A+ E E+ S +
Sbjct: 906 RARLAEQLR-AEAELCAEAEETRGRLAARKQELELVVSELEAR--VGEEEECSRQMQTEK 962
Query: 910 -RLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLE 968
RLQ IQ L L+A + R +L+K +++ E++ + +++ K LE
Sbjct: 963 KRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLE 1022
Query: 969 EKVSRLETELDEEKNTVELLT--------------DRV---NRGRDQVDQLRTEL----- 1006
++++ ++ EE+ V+ L DR+ +GR ++++L+ L
Sbjct: 1023 DRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS 1082
Query: 1007 -MQERSARQDLECDKI--SLERQNKDLKTRL--ASSEGFQKPSASLSQLESQNQL--LQE 1059
+QE+ Q +++ L R+ ++L+ L A EG + S E+Q L QE
Sbjct: 1083 ELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQE 1142
Query: 1060 RLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEE 1119
L++E +T + R L +++ L ++ED N Q++ S R +++V E ++
Sbjct: 1143 DLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKR----EQEVTELKK 1198
Query: 1120 EIERLDGLRKKAQREVEEQH-----EVNEQLQARIKSLEKDSWRKASRSAAES 1167
+E + + A +E+ ++H E+ EQL+ + K +W K +R A E+
Sbjct: 1199 TLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG--KGAWEK-TRLALEA 1248
Score = 75.5 bits (184), Expect = 3e-13
Identities = 103/429 (24%), Positives = 195/429 (45%), Gaps = 56/429 (13%)
Query: 750 RGLVDGGEAVEARLR-----DKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEE 804
+G +DG +A E ++ L R+ K + A EEE L + +
Sbjct: 755 KGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTD--IIVSFQA 812
Query: 805 AQRG-LARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGE 863
A RG LAR RA ++ +Q+ LR + +L RL +++ + +
Sbjct: 813 AARGYLAR---------RAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQ 863
Query: 864 DSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQ 923
++Q + LQA+ ++ ++ V + Q+Q+ A E + G +++L++E RL + L+
Sbjct: 864 VTRQD-EVLQARAQELQK-----VQELQQQS---AREVGELQGRVAQLEEERARLAEQLR 914
Query: 924 ASQAERDTARLDKELLAQRLQGLE---QEAENKKRSQDDRARQL----KGLEEKVSRLET 976
A A + LA R Q LE E E + +++ +RQ+ K L++ + LE
Sbjct: 915 AEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEA 974
Query: 977 ELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDL--ECDKISLERQNKDLKTRL 1034
L+ E+ + L Q++++ TE ++ L E L ++ K L+ RL
Sbjct: 975 HLEAEEGARQKL---------QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1025
Query: 1035 A--SSEGFQKPSA--SLSQLESQNQL----LQERLQAEEREKTVLQSTNRKLERKVKELS 1086
A SS+ ++ SL++L + + +++RL+ EE+ + L+ R+L+ + EL
Sbjct: 1026 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1085
Query: 1087 IQIEDERQHVNDQKDQLSLRVK----ALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVN 1142
Q+ +++Q + + QL + + AL R DE + L LR+ E Q ++
Sbjct: 1086 EQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLE 1145
Query: 1143 EQLQARIKS 1151
+ AR K+
Sbjct: 1146 SERVARTKA 1154
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 244 bits (622), Expect = 5e-64
Identities = 246/950 (25%), Positives = 433/950 (45%), Gaps = 137/950 (14%)
Query: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 422
E + + E + K+ K R K E + +E +L ++ + L++L R GE+ + +
Sbjct: 1068 EFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE 1127
Query: 423 ELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLE- 481
++ ++ + E+LR L + ELQ L + A+ LLK L E + L E E
Sbjct: 1128 QMVEQQQ---RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1184
Query: 482 ------GKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQD 535
+ + E+Q R EL AL+G L++ + S + + E +R + +++ +L++++++
Sbjct: 1185 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE-LRSKREQEVTELKKTLEE 1243
Query: 536 ATQDH-AVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRM 594
T+ H A ++ RQ+ + L +LE+ G W+ + ++ + EL L+
Sbjct: 1244 ETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQT 1303
Query: 595 EKEEMEE------------------------ELGEKIEVLQRELEQARASAGDTRQVEV- 629
++E E+ E EK++ Q ELE + + +
Sbjct: 1304 ARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIR 1363
Query: 630 LKKELLRTQEEL---KELQAERQSQEVAGRHRDRELEKQLAVLRVEADR--------GRE 678
L KEL T+ +L +EL E ++A R R +E + A LR + + GRE
Sbjct: 1364 LSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRE 1423
Query: 679 LEEQNLQLQKTLQQLRQDC---EEASKAKMVAEAEATVLGQRRAAVETTL-------RET 728
L+ QL + ++ ++ E +A+ A EA L QR A T+ R
Sbjct: 1424 LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRL 1483
Query: 729 QEENDEF-------RRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLE--- 778
Q+E D+ R+ + LE++ ++ L+ +A R ++ +R EAE ++ E
Sbjct: 1484 QQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARA 1543
Query: 779 ----EALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLR 834
AL QE L RAL A LE +G+ L RA + LR
Sbjct: 1544 LSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLR 1603
Query: 835 RGKAELE-------EQKRLLDRTVDRLNKELEK-------IGEDSKQAL--QQLQAQLED 878
ELE + K L+ TV L + E+ GE+ ++ L Q A++E
Sbjct: 1604 AQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVER 1663
Query: 879 YKEKARREVADAQRQAKDWASE---AEKTSGG---------LSRLQDEIQRLRQALQASQ 926
+E+ +R +A A R+ + E A+ S G L ++Q +++ L + ++ ++
Sbjct: 1664 DEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR 1723
Query: 927 AERDTARLDKELLAQRLQGLEQEA-----------ENKKRSQDDR--------------- 960
R+ +RL+GLE E ++++Q DR
Sbjct: 1724 TSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKA 1783
Query: 961 --ARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLEC 1018
+ + LE ++ +LE EL+EE++ ELL DR + QV+ L TEL ERS E
Sbjct: 1784 AILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAES 1843
Query: 1019 DKISLERQNKDLKTRLASSEGFQKP--SASLSQLESQNQLLQERLQAEEREKTVLQSTNR 1076
+ LERQ ++L+ RL + + +++ LES+ +E+L+ E RE+ + R
Sbjct: 1844 GRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1903
Query: 1077 KLERKVKELSIQIEDERQHVNDQKDQL---SLRVKALKRQVDEAEEEIERLDGLRKKAQR 1133
+ E+++KE+ +Q+E+ER+ + +DQL +LRVK LKRQ++EAEEE R R++ QR
Sbjct: 1904 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1963
Query: 1134 EVEEQHEVNEQLQARIKSLEKDSWRK----ASRSAAESALKNEGLSSDEE 1179
E+E+ E E + + +L R +R+ + EG++SDEE
Sbjct: 1964 ELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEE 2013
Score = 172 bits (436), Expect = 2e-42
Identities = 225/943 (23%), Positives = 403/943 (42%), Gaps = 142/943 (15%)
Query: 343 KMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQ----KLEPSQVGLERQLEE 398
K++PL+ V+ A EL +KV+ELQ++ EV + Q +LE + L QL
Sbjct: 898 KVKPLLQVTRQDEVLQARAQEL-QKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRA 956
Query: 399 KTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLK----H 454
+ E C+ +E R Q+ + ++ + + E+ ++T+ LQ ++ H
Sbjct: 957 EAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAH 1016
Query: 455 VQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQE 514
++ E A++ L + + T +++ E +E+Q +E L+ L E + +E
Sbjct: 1017 LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEE 1076
Query: 515 VEHVRQ--QYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQ 572
E V+ + + E M+D + E RQ++ L R L E E E+
Sbjct: 1077 EEKVKSLNKLRLKYEATIADMEDRLRKE---EKGRQELEKLKRRLDGESSELQEQ----- 1128
Query: 573 SMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKK 632
+++ + EE+ +LG K E LQ L +A G Q L K
Sbjct: 1129 ----------------MVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQ---LLK 1169
Query: 633 ELLRTQEELKELQAERQSQEVA---GRHRDRELEKQLAVLRVE-------ADRGREL--- 679
L Q L E Q + +S+ VA + R+L ++L LR E + +EL
Sbjct: 1170 SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSK 1229
Query: 680 -EEQNLQLQKTL-----------QQLRQDCEEA------------------SKAKMVAEA 709
E++ +L+KTL Q+LRQ +A K ++ EA
Sbjct: 1230 REQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEA 1289
Query: 710 EATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQR 769
E + L ++++T ++E ++ RRR LE QL+E +G GE A +KLQR
Sbjct: 1290 EVSELRAELSSLQT----ARQEGEQRRRR---LELQLQEVQGRAGDGERARAEAAEKLQR 1342
Query: 770 LEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQ-------RGLARLGQ-------E 815
+AE + + ALN ++ + L+ + EA+L +AQ R LG E
Sbjct: 1343 AQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAE 1402
Query: 816 QQTLNRALEEEGKQRE----VLRRGKAELEEQKRLLDRTVDRL--NKELEKIGEDSKQAL 869
L LEEE RE L+ +A+L E +R + L +E + +AL
Sbjct: 1403 AAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1462
Query: 870 QQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQA-- 927
Q A+ + ++ R Q++ D + E+ +S L+ + ++ Q L +A
Sbjct: 1463 TQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV 1522
Query: 928 -----ERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEK 982
ER+ A + R L + E ++ ++++ RQ + L ++ L + D+
Sbjct: 1523 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVG 1582
Query: 983 NTVELL-------TDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQN-KDLKTRL 1034
+V L N R QV +L EL A+ LE +L+ Q+ +DL+ R
Sbjct: 1583 KSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRD 1642
Query: 1035 ASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQ 1094
+ E ++ QL Q + + E +++T+ + +KLE +++EL Q+ Q
Sbjct: 1643 EAGEERRR------QLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ 1696
Query: 1095 HVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEK 1154
K++ +++ ++ Q+ E E+E + + EE N + + R+K LE
Sbjct: 1697 ----GKEEAVKQLRKMQAQMKELWREVE-------ETRTSREEIFSQNRESEKRLKGLEA 1745
Query: 1155 DSWR-KASRSAAESALKNEGLSSDEEFDSVYDPS-SIASLLTE 1195
+ R + +A++ A + DE D V + + S A++L E
Sbjct: 1746 EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEE 1788
Score = 118 bits (296), Expect = 3e-26
Identities = 159/665 (23%), Positives = 289/665 (43%), Gaps = 91/665 (13%)
Query: 318 IYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE----LQR 373
+ G L E S++ + +++S ++ + T+A G R +E L+
Sbjct: 1350 VSGALNEAESKT-IRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1408
Query: 374 KLDEEVKKRQK----LEPSQVGLERQLEEKTEECSRLQ---ELLERRKGEAQQSNKELQN 426
+L+EE R++ L+ +Q L + EE L+ E R EA+ + L
Sbjct: 1409 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAE 1468
Query: 427 MKRLLDQGE----DLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEG 482
+D+ E L+ L+ M+L+ + + V E + + L E + + +E
Sbjct: 1469 KTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1528
Query: 483 KQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAV 542
++R E + R RE +L AL+EE +R +E+E + + + E L S D +
Sbjct: 1529 RERAEAEGREREARALSLTRALEEEQEAR-EELERQNRALRAELEALLSSKDDVGKSVHE 1587
Query: 543 LEAERQKMSALVRGLQRELEETSEE-------------------TGHWQSMFQKNKEDLR 583
LE + L+ ++ E +E T H + + +++
Sbjct: 1588 LERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEE 1647
Query: 584 ATKQELLQLRMEKEEMEEE---------LGEKIEVLQRELEQARASAGDTRQVEVLKKEL 634
+Q QLR + E +EE +K+E EL+ ASAG ++ V K+L
Sbjct: 1648 RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAV--KQL 1705
Query: 635 LRTQEELKELQAERQSQEVAGRH---RDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQ 691
+ Q ++KEL E + + ++RE EK+L L E R L+E+ + +
Sbjct: 1706 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLR---LQEELAASDRARR 1762
Query: 692 QLRQDCEE---------ASKAKMVAEAEATV--LGQRRAAVETTLRETQEENDEFRRRIL 740
Q +QD +E SKA ++ E LGQ +E ++ ND +R+ +L
Sbjct: 1763 QAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLL 1822
Query: 741 GLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAK---RA 797
+E E + + A+ Q+LE + Q+L L +E+ G+ A K A
Sbjct: 1823 QVESLTTE----LSAERSFSAKAESGRQQLERQIQELRGRL--GEEDAGARARHKMTIAA 1876
Query: 798 LEARLEEAQRGLARLGQEQQTLNRALEEEGKQR--EVLRRGKAELEEQKRLLDRTVDRLN 855
LE++L +A+ L EQ+T R L + +R + L+ ++EE++R+ D+ D+L
Sbjct: 1877 LESKLAQAEEQL-----EQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLE 1931
Query: 856 KELEKIGEDSKQALQQLQAQLEDYKEKARREVAD---AQRQAKDWASEAEKTSGGLSRLQ 912
K ++QL+ QLE+ +E+A R A QR+ +D AE + ++ L+
Sbjct: 1932 K--------GNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLR 1983
Query: 913 DEIQR 917
+ ++R
Sbjct: 1984 NRLRR 1988
Score = 111 bits (277), Expect = 5e-24
Identities = 151/611 (24%), Positives = 266/611 (43%), Gaps = 78/611 (12%)
Query: 246 GTSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPT------MLQFKSTPDLL 299
G Q AQ+Q LS + R ++ + L++ EE RR A + + T D L
Sbjct: 1421 GRELQTAQAQ----LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1476
Query: 300 ----RDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGST 355
R Q+ ++D + R+ S E R+ L+ E+ ++
Sbjct: 1477 ERGRRRLQQELDDATMDLEQQ------RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERE 1530
Query: 356 KAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKG 415
+A A E + L R L+EE + R++LE L +L E L K
Sbjct: 1531 RAEAEGREREARALSLTRALEEEQEAREELERQNRALRAEL-----------EALLSSKD 1579
Query: 416 EAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETREL 475
+ +S EL+ R+ +Q + L QV EL+++L + + EV ++ L+T+
Sbjct: 1580 DVGKSVHELERACRVAEQA---ANDLRAQVTELEDELTAAEDAKLRLEVTVQ-ALKTQH- 1634
Query: 476 LEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEH------VRQQYQRDTEQL 529
E L+G+ E+ R R+L L++ RD+E + R++ + + E+L
Sbjct: 1635 -ERDLQGRDEAGEE---RRRQLAK---QLRDAEVERDEERKQRTLAVAARKKLEGELEEL 1687
Query: 530 RRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQEL 589
+ M A Q + +KM A ++ L RE+EET S +++++ L+ + E+
Sbjct: 1688 KAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEV 1747
Query: 590 LQL----------RMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQE 639
L+L R + ++ +E+ + EV L +A A + RQ+E L + +E
Sbjct: 1748 LRLQEELAASDRARRQAQQDRDEMAD--EVANGNLSKA-AILEEKRQLE---GRLGQLEE 1801
Query: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADR--GRELEEQNLQLQKTLQQLR--- 694
EL+E Q+ S+ + R+R L+ + + A+R + E QL++ +Q+LR
Sbjct: 1802 ELEEEQS--NSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1859
Query: 695 --QDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGL 752
+D ++ KM A + L Q +E RE RR E++LKE
Sbjct: 1860 GEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRR----AEKRLKEVVLQ 1915
Query: 753 VDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARL 812
V+ V +LRD+L++ +QL+ L ++EE A +R L+ LE+ +
Sbjct: 1916 VEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESM 1975
Query: 813 GQEQQTLNRAL 823
+E TL L
Sbjct: 1976 NREVTTLRNRL 1986
Score = 82.4 bits (202), Expect = 2e-15
Identities = 110/473 (23%), Positives = 214/473 (45%), Gaps = 60/473 (12%)
Query: 741 GLEQQLKETRGL--VDGGEAVEARLRDKLQRLEAEK-QQLEEALNASQEEEGSLAAAKRA 797
G+ QL+E R L D + +A R L R +K QQ + AL Q + +
Sbjct: 831 GVLAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHW 890
Query: 798 LEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKE 857
RL + L ++ ++ + L +E K +E+ ++ E+ E L V +L +E
Sbjct: 891 QWWRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGE----LQGRVAQLEEE 946
Query: 858 LEKIGEDSKQALQQLQAQLEDYK-----EKARREVADAQRQAKDWASEAEKTSGGLS--- 909
++ E + A +L A+ E+ + K E+ ++ +A+ E E+ S +
Sbjct: 947 RARLAEQLR-AEAELCAEAEETRGRLAARKQELELVVSELEAR--VGEEEECSRQMQTEK 1003
Query: 910 -RLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLE 968
RLQ IQ L L+A + R +L+K +++ E++ + +++ K LE
Sbjct: 1004 KRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLE 1063
Query: 969 EKVSRLETELDEEKNTVELLT--------------DRV---NRGRDQVDQLRTEL----- 1006
++++ ++ EE+ V+ L DR+ +GR ++++L+ L
Sbjct: 1064 DRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS 1123
Query: 1007 -MQERSARQDLECDKI--SLERQNKDLKTRL--ASSEGFQKPSASLSQLESQNQL--LQE 1059
+QE+ Q +++ L R+ ++L+ L A EG + S E+Q L QE
Sbjct: 1124 ELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQE 1183
Query: 1060 RLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEE 1119
L++E +T + R L +++ L ++ED N Q++ S R +++V E ++
Sbjct: 1184 DLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKR----EQEVTELKK 1239
Query: 1120 EIERLDGLRKKAQREVEEQH-----EVNEQLQARIKSLEKDSWRKASRSAAES 1167
+E + + A +E+ ++H E+ EQL+ + K +W K +R A E+
Sbjct: 1240 TLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRG--KGAWEK-TRLALEA 1289
Score = 75.5 bits (184), Expect = 3e-13
Identities = 103/429 (24%), Positives = 195/429 (45%), Gaps = 56/429 (13%)
Query: 750 RGLVDGGEAVEARLR-----DKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEE 804
+G +DG +A E ++ L R+ K + A EEE L + +
Sbjct: 796 KGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTD--IIVSFQA 853
Query: 805 AQRG-LARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGE 863
A RG LAR RA ++ +Q+ LR + +L RL +++ + +
Sbjct: 854 AARGYLAR---------RAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQ 904
Query: 864 DSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQ 923
++Q + LQA+ ++ ++ V + Q+Q+ A E + G +++L++E RL + L+
Sbjct: 905 VTRQD-EVLQARAQELQK-----VQELQQQS---AREVGELQGRVAQLEEERARLAEQLR 955
Query: 924 ASQAERDTARLDKELLAQRLQGLE---QEAENKKRSQDDRARQL----KGLEEKVSRLET 976
A A + LA R Q LE E E + +++ +RQ+ K L++ + LE
Sbjct: 956 AEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEA 1015
Query: 977 ELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDL--ECDKISLERQNKDLKTRL 1034
L+ E+ + L Q++++ TE ++ L E L ++ K L+ RL
Sbjct: 1016 HLEAEEGARQKL---------QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1066
Query: 1035 A--SSEGFQKPSA--SLSQLESQNQL----LQERLQAEEREKTVLQSTNRKLERKVKELS 1086
A SS+ ++ SL++L + + +++RL+ EE+ + L+ R+L+ + EL
Sbjct: 1067 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1126
Query: 1087 IQIEDERQHVNDQKDQLSLRVK----ALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVN 1142
Q+ +++Q + + QL + + AL R DE + L LR+ E Q ++
Sbjct: 1127 EQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLE 1186
Query: 1143 EQLQARIKS 1151
+ AR K+
Sbjct: 1187 SERVARTKA 1195
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 191 bits (485), Expect = 4e-48
Identities = 193/851 (22%), Positives = 377/851 (44%), Gaps = 66/851 (7%)
Query: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 422
EL ++EEL+ +L+ E R K+E + L R+LEE +E RL+E + + + K
Sbjct: 1110 ELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISE---RLEEAGGATSVQIEMNKK 1166
Query: 423 ---ELQNMKRLLDQGE--------DLRHGLETQVMELQNKLKHVQGP----EPAKEVLLK 467
E Q M+R L++ LR V EL ++ ++Q E K
Sbjct: 1167 REAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL 1226
Query: 468 DLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTE 527
+L + +E++++ K +E+ R E ++ + +E S + ++ R + Q +
Sbjct: 1227 ELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN-DLTSQRAKLQTENG 1285
Query: 528 QLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQ 587
+L R + + + L + + + L+R+LEE + Q + D ++
Sbjct: 1286 ELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLRE 1345
Query: 588 ELLQLRMEKEEMEEELGE-KIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQA 646
+ + K E++ L + EV Q + + T ++E KK+L + +E +E
Sbjct: 1346 QYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVE 1405
Query: 647 ERQSQEVAGRHRDRELEKQLAVLRVEADRGRE----LEEQNLQLQKTLQQLRQDCEEASK 702
++ + L+ ++ L V+ +R L+++ K L + +Q EE+
Sbjct: 1406 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1465
Query: 703 AKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKE-TRGLVDGGEAVEA 761
++ EA L ++ E+ E + F+R L++++ + T L G+ +
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIH- 1524
Query: 762 RLRDKLQRLEAEKQQLEEALNASQ----EEEGSLAAAKRALEARLEEAQRGLARLGQEQQ 817
L ++LEAEK +L+ AL ++ EEG + A+ E +R LA +E +
Sbjct: 1525 ELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEME 1584
Query: 818 -----------TLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSK 866
+L +L+ E + R R K ++E ++ + N+ + +++
Sbjct: 1585 QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANR----MAAEAQ 1640
Query: 867 QALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQ 926
+ ++ LQ+ L+D + ++ DA R D + LQ E++ LR ++ ++
Sbjct: 1641 KQVKSLQSLLKD----TQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE 1696
Query: 927 AERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVE 986
R A + ++R+Q L + Q K ++ +S+L+TE++E
Sbjct: 1697 RSRKLAEQELIETSERVQLLHSQ-------NTSLINQKKKMDADLSQLQTEVEEAVQECR 1749
Query: 987 LLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE--GFQKPS 1044
++ + + EL +E+ LE K ++E+ KDL+ RL +E +
Sbjct: 1750 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGK 1809
Query: 1045 ASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQH---VNDQKD 1101
L +LE++ + L+ L+AE++ RK ER++KEL+ Q E++R++ + D D
Sbjct: 1810 KQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVD 1869
Query: 1102 QLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKAS 1161
+L L+VKA KRQ +EAEE+ +K Q E++E E + ++++ L R S
Sbjct: 1870 KLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL-----RAKS 1924
Query: 1162 RSAAESALKNE 1172
R L E
Sbjct: 1925 RDIGTKGLNEE 1935
Score = 152 bits (383), Expect = 2e-36
Identities = 194/883 (21%), Positives = 386/883 (43%), Gaps = 112/883 (12%)
Query: 343 KMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEE 402
K++PL+ + + + + E TR L+ L++ +R++LE V L L+EK +
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTR----LKEALEKSEARRKELEEKMVSL---LQEKNDL 887
Query: 403 CSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAK 462
++Q A+Q N L + + DQ + LE +V E+ +L E +
Sbjct: 888 QLQVQ---------AEQDN--LADAEERCDQLIKNKIQLEAKVKEMNERL------EDEE 930
Query: 463 EVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEV---EHVR 519
E+ + + R+L +E E K+ +++ L L ++ K A + +V + +E+ + +
Sbjct: 931 EMNAELTAKKRKLEDECSELKRDIDD-LELTLAKVEKEKHATENKVKNLTEEMAGLDEII 989
Query: 520 QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRG----------LQRELEETSEETG 569
+ ++ + L+ + Q A D L+AE K++ L + L+ LE+ +
Sbjct: 990 AKLTKEKKALQEAHQQALDD---LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRM 1046
Query: 570 HWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEK---IEVLQRELEQARASAGDTRQ 626
+ +K + DL+ T++ ++ L +K++++E L +K + L +E +A Q
Sbjct: 1047 DLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGS---Q 1103
Query: 627 VEVLKKELLRTQEELKE-LQAERQSQEVAGRHRD---RELEKQLAVLRVEADRGRELEEQ 682
++ KEL EEL+E L+AER ++ + R RELE+ L E
Sbjct: 1104 LQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEM 1163
Query: 683 NLQLQKTLQQLRQDCEEASKAKMVAEA--------EATVLGQRRAAVETTLRETQEENDE 734
N + + Q++R+D EEA+ A LG++ ++ ++ ++E E
Sbjct: 1164 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1223
Query: 735 FRRRI----LGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNAS---QEE 787
F+ + +EQ +K L +E ++ + + E ++ + + + Q E
Sbjct: 1224 FKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283
Query: 788 EGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQR--------------EVL 833
G L+ EA + + RG Q+ + L R LEEE K + ++L
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 834 RRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQ 893
R E E K L R + + N E+ + + Q +LE+ K+K + + +A+
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEA 1403
Query: 894 AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDK------ELLAQRLQGLE 947
+ ++ RLQ+EI+ L ++ S A A LDK ++LA+ Q E
Sbjct: 1404 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA--AAALDKKQRNFDKILAEWKQKYE 1461
Query: 948 QEAENKKRSQDDRARQL--------KGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQV 999
E++++ S AR L EE + LET E KN E ++D +Q+
Sbjct: 1462 -ESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLT----EQL 1516
Query: 1000 DQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEG--------FQKPSASLSQLE 1051
+ + R+ LE +K+ L+ ++ + L EG F + A + +
Sbjct: 1517 GSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL 1576
Query: 1052 SQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALK 1111
++ +E QA+ V+ S L+ + + + + +++ D +++ +++
Sbjct: 1577 AEKD--EEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGD-LNEMEIQLSHAN 1633
Query: 1112 RQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEK 1154
R EA+++++ L L K Q ++++ N+ L+ I +E+
Sbjct: 1634 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVER 1676
Score = 71.6 bits (174), Expect = 4e-12
Identities = 76/326 (23%), Positives = 143/326 (43%), Gaps = 29/326 (8%)
Query: 898 ASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLE---QEAENKK 954
++E EK ++ +++E RL++AL+ S+A R L Q L+ Q ++
Sbjct: 842 SAEREKE---MASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNL 898
Query: 955 RSQDDRARQLKG----LEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQER 1010
++R QL LE KV + L++E+ LT + + D+ +L+ ++
Sbjct: 899 ADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE 958
Query: 1011 SARQDLECDKISLERQNKDLKTRLAS-SEGFQKPSASLSQLESQNQLLQERLQAEEREKT 1069
+E +K + E + K+L +A E K + L+ +Q + LQAEE +
Sbjct: 959 LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVN 1018
Query: 1070 VLQSTNRKLERKVKELSIQIEDE---RQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDG 1126
L KLE++V +L +E E R + K +L +K + + + E + ++LD
Sbjct: 1019 TLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDE 1078
Query: 1127 LRKKAQRE-------VEEQHEVNEQLQ-------ARIKSLEKD-SWRKASRSAAESALKN 1171
KK E +E++ + QLQ ARI+ LE++ + +R+ E +
Sbjct: 1079 RLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSD 1138
Query: 1172 EGLSSDEEFDSVYDPSSIASLLTESN 1197
+E + + + S+ E N
Sbjct: 1139 LSRELEEISERLEEAGGATSVQIEMN 1164
Score = 51.2 bits (121), Expect = 6e-06
Identities = 62/279 (22%), Positives = 128/279 (45%), Gaps = 39/279 (13%)
Query: 906 GGLSRLQDE-IQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQL 964
G L ++DE + R+ +QA Q+ AR++ + L +R L N + +
Sbjct: 771 GLLEEMRDERLSRIITRIQA-QSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPW 829
Query: 965 KGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLE 1024
L K+ L + EK + +++ +L+ L + + R++LE +SL
Sbjct: 830 MKLYFKIKPLLKSAEREKEMASM--------KEEFTRLKEALEKSEARRKELEEKMVSLL 881
Query: 1025 RQNKDLKTRLASSEGFQKPSASLSQLESQ-NQLLQERLQAEEREKTVLQSTNRKLERKVK 1083
++ DL+ ++ + + +L+ E + +QL++ ++Q LE KVK
Sbjct: 882 QEKNDLQLQVQAEQD------NLADAEERCDQLIKNKIQ---------------LEAKVK 920
Query: 1084 ELSIQIEDERQ---HVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHE 1140
E++ ++EDE + + +K +L LKR +D+ E + +++ + + +V+ E
Sbjct: 921 EMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTE 980
Query: 1141 VNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEE 1179
L I L K+ +KA + A + AL + L ++E+
Sbjct: 981 EMAGLDEIIAKLTKE--KKALQEAHQQAL--DDLQAEED 1015
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 187 bits (476), Expect = 4e-47
Identities = 187/830 (22%), Positives = 372/830 (44%), Gaps = 51/830 (6%)
Query: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 422
EL ++EEL+ +++ E R K E + L R+LEE +E RL+E + + + K
Sbjct: 1116 ELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISE---RLEEAGGATSAQIEMNKK 1172
Query: 423 ---ELQNMKRLLDQGE--------DLRHGLETQVMELQNKLKHVQGP----EPAKEVLLK 467
E Q M+R L++ LR V EL ++ ++Q E K +
Sbjct: 1173 REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKM 1232
Query: 468 DLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTE 527
++ + +E V + K +E+ R E +L+ LK +EE ++ R + Q ++
Sbjct: 1233 EIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSK-EEEQQRLINDLTAQRGRLQTESG 1291
Query: 528 QLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQ 587
+ R + + + L +Q + + L+R+LEE + Q ++ D ++
Sbjct: 1292 EFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLRE 1351
Query: 588 ELLQLRMEKEEMEEELGE-KIEVLQRELEQARASAGDTRQVEVLKKELLR----TQEELK 642
+ + + K E++ L + EV Q + + T ++E KK+L + +E ++
Sbjct: 1352 QYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVE 1411
Query: 643 ELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASK 702
+ A+ S E + E+E + + L+++ K L + +Q CEE
Sbjct: 1412 AVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHA 1471
Query: 703 AKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKE-TRGLVDGGEAVEA 761
++ EA LG ++ E+ ++ + +R L+Q++ + T + +GG+ +
Sbjct: 1472 ELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE 1531
Query: 762 RLRDKLQRLEAEKQQLEEALNASQ----EEEGSLAAAKRALEARLEEAQRGLARLGQEQQ 817
+ K Q +E EK +L+ AL ++ EEG + + L E R +A +E
Sbjct: 1532 LEKIKKQ-VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590
Query: 818 TLNR----ALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQ 873
L R +E + R + + K+ ++ ++ + +L + +AL+ +
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYR 1650
Query: 874 AQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTAR 933
+ + + + DA R +D + + LQ EI+ LR L+ Q ER
Sbjct: 1651 -NTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLE--QTERSRKI 1707
Query: 934 LDKELL--AQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDR 991
++ELL ++R+Q L + + ++ K LE +S+++ E+++ ++
Sbjct: 1708 AEQELLDASERVQLLHTQNTSLINTK-------KKLETDISQMQGEMEDILQEARNAEEK 1760
Query: 992 VNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE--GFQKPSASLSQ 1049
+ + EL +E+ LE K ++E+ KDL+ RL +E + + +
Sbjct: 1761 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQK 1820
Query: 1050 LESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHV---NDQKDQLSLR 1106
LE++ + L+ +++E++ RK ER+VKEL+ Q E++R+++ D D+L +
Sbjct: 1821 LEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAK 1880
Query: 1107 VKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDS 1156
VK+ KRQ +EAEE+ +K Q E+EE E + ++++ L S
Sbjct: 1881 VKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKS 1930
Score = 142 bits (357), Expect = 2e-33
Identities = 199/914 (21%), Positives = 386/914 (42%), Gaps = 155/914 (16%)
Query: 342 EKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTE 401
EKM L+ + V + E EE + D+ +K + +LE + + E++ E
Sbjct: 881 EKMVTLLKEKNDLQLQVQAEAEGLADAEE---RCDQLIKTKIQLEAKIKEVTERAEDEEE 937
Query: 402 ECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPA 461
+ L + + E + K++ +++ L + E +H E +V +N + + G +
Sbjct: 938 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV---KNLTEEMAGLDET 994
Query: 462 KEVLLKDLLETRELLEEVLEGKQRVEEQLRLR-------ERELTALKGALKEEVASRDQE 514
L K+ +E ++ L+ Q E+++ E+++ L+G+L++E R +
Sbjct: 995 IAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLR-MD 1053
Query: 515 VEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSM 574
+E +++ + D + + S+ D + L+ + +K + LQ ++E+
Sbjct: 1054 LERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIED----------- 1102
Query: 575 FQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARAS-AGDTRQVEVLKKE 633
++ L ++++K+ +EL +IE L+ E+E RAS A +Q L +E
Sbjct: 1103 ------------EQALGIQLQKKI--KELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1148
Query: 634 LLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQL 693
L E L+E +Q + R+ E +K R+LEE LQ + T L
Sbjct: 1149 LEEISERLEEAGGATSAQIEMNKKREAEFQKMR----------RDLEEATLQHEATAATL 1198
Query: 694 RQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLV 753
R+ A VAE LG++ ++ ++ ++E E + I L ++
Sbjct: 1199 RK-----KHADSVAE-----LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248
Query: 754 DGGEAVEARLRDKLQRLEAEKQQLEEALN-------ASQEEEGSLAAAKRALEARLEEAQ 806
E + L D+L L++++++ + +N Q E G + EA + +
Sbjct: 1249 GNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLS 1308
Query: 807 RGLARLGQEQQTLNRALEEEGKQR--------------EVLRRGKAELEEQKRLLDRTVD 852
RG Q+ + L R LEEE K + ++LR E +E K L R +
Sbjct: 1309 RGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALS 1368
Query: 853 RLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQ 912
+ N E+ + + Q +LE+ K+K + + A+ + ++ RLQ
Sbjct: 1369 KANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ 1428
Query: 913 DEIQRLRQALQASQAERDTARLDK------ELLAQRLQGLEQEAENKKRSQDDRARQL-- 964
+E++ L L + A LDK ++LA+ Q E+ + SQ + AR L
Sbjct: 1429 NEVEDL--MLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKE-ARSLGT 1485
Query: 965 ------KGLEEKVSRLETELDEEKN---TVELLTDRVNRGRDQV---DQLRTELMQERSA 1012
EE + +LET E KN + LT+++ G ++ ++++ ++ QE+
Sbjct: 1486 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545
Query: 1013 RQ-DLECDKISLE-RQNKDLKTRLASSEGFQKPSASLSQLESQ-NQL----------LQE 1059
Q LE + SLE + K L+ +L ++ + +++ + + +QL +Q
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQS 1605
Query: 1060 RLQAEEREKTVLQSTNRKLERKVKELSIQ---------------------IEDERQHVND 1098
L AE R + +K+E + E+ IQ ++D + H++D
Sbjct: 1606 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD 1665
Query: 1099 Q-------KDQLSL---RVKALKRQVDEAEEEIERLDGLRKKAQRE-------VEEQHEV 1141
K+QL++ R L+ +++E +E+ + RK A++E V+ H
Sbjct: 1666 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1725
Query: 1142 NEQLQARIKSLEKD 1155
N L K LE D
Sbjct: 1726 NTSLINTKKKLETD 1739
Score = 118 bits (295), Expect = 4e-26
Identities = 136/631 (21%), Positives = 292/631 (46%), Gaps = 82/631 (12%)
Query: 571 WQSMFQKNKEDLRA--TKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVE 628
W +F K K L++ T++E+ ++ E +++++EL K E ++ELE+ +
Sbjct: 835 WMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELA-KSEAKRKELEEKMVT-------- 885
Query: 629 VLKKELLRTQEELK-ELQAERQSQEVAGRHRDRELEKQL---AVLRVEADRGRELEEQNL 684
LL+ + +L+ ++QAE + A D+ ++ ++ A ++ +R + EE N
Sbjct: 886 -----LLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINA 940
Query: 685 QLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQ 744
+L ++L +C E K + + E T+ A VE T+ + + GL++
Sbjct: 941 ELTAKKRKLEDECSELKKD--IDDLELTL-----AKVEKEKHATENKVKNLTEEMAGLDE 993
Query: 745 QLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEE 804
+ A+L + + L+ QQ + L A +++ +L AK LE ++++
Sbjct: 994 TI--------------AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD 1039
Query: 805 AQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKEL------ 858
+ L + + + L RA + ++ + ++E +K+ LD + + E+
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSK 1099
Query: 859 ----EKIGEDSKQALQQLQAQLEDYKEKARREVAD---AQRQAKDWASEAEKTS------ 905
+ +G ++ +++LQA++E+ +E+ E A A++Q D + E E+ S
Sbjct: 1100 IEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEA 1159
Query: 906 GGLSRLQDEIQRLRQA-LQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQL 964
GG + Q E+ + R+A Q + + + A L E A L+ ++ + Q D +++
Sbjct: 1160 GGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV 1219
Query: 965 KG-LEEKVSRLETELDEEKNTVELLT------DRVNRG-RDQVDQLRTELMQERSARQDL 1016
K LE++ S ++ E+D+ + VE ++ +++ R DQ+ +L+++ +++ DL
Sbjct: 1220 KQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDL 1279
Query: 1017 ECDKISLERQNKDLKTRLASSEGF-----QKPSASLSQLESQNQLLQERLQAEEREKTVL 1071
+ L+ ++ + +L E + A Q+E + L+E ++A+ L
Sbjct: 1280 TAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHAL 1339
Query: 1072 QSTNRKLERKVKELSIQIEDERQHVNDQKDQLS---LRVKALKRQVD-EAEEEIERLDGL 1127
QS+ + L Q E+E++ + + LS V + + + +A + E L+
Sbjct: 1340 QSSRHDCDL----LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEA 1395
Query: 1128 RKKAQREVEEQHEVNEQLQARIKSLEKDSWR 1158
+KK + ++ E E + A+ SLEK R
Sbjct: 1396 KKKLAQRLQAAEEHVEAVNAKCASLEKTKQR 1426
Score = 117 bits (292), Expect = 9e-26
Identities = 170/817 (20%), Positives = 335/817 (41%), Gaps = 176/817 (21%)
Query: 356 KAVAGQGELTRKVEELQRKLDE-------EVKKRQKLEPSQVGLERQLEEKTEECSRLQE 408
KA + +L+R++EE+ +L+E +++ +K E + R LEE T +
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196
Query: 409 LLERRKGEA-QQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLK 467
L ++ ++ + +++ N++R+ + E + ++ ME+ + +V+ AK L K
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK---MEIDDLASNVETVSKAKGNLEK 1253
Query: 468 DLLETRELLEEVLEGKQRVEEQLRLRERELTALKGAL-------------KEEVASR--- 511
R L +++ E K + EEQ RL +LTA +G L KE + S+
Sbjct: 1254 ---MCRTLEDQLSELKSKEEEQQRLIN-DLTAQRGRLQTESGEFSRQLDEKEALVSQLSR 1309
Query: 512 -----DQEVEHVRQQYQRDTEQ---LRRSMQDATQDHAVLEAERQKMSALVRGLQRELEE 563
Q++E +++Q + + + L ++Q + D +L + ++ LQR L +
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369
Query: 564 TSEETGHWQSMFQ----KNKEDLRATKQELLQLRMEKEEMEEELGEKI-------EVLQR 612
+ E W++ ++ + E+L K++L Q EE E + K + LQ
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQN 1429
Query: 613 ELEQ---------ARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELE 663
E+E A +A D +Q K L +++ +E AE ++ + R EL
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRN-FDKILAEWKQKCEETHAELEASQKEARSLGTELF 1488
Query: 664 KQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVET 723
K D+ L+ +N LQ+ + L + E K E + Q + ++
Sbjct: 1489 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA 1548
Query: 724 TLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQR------------LE 771
L E + + +IL ++ +L + + VD A + D+L+R L+
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD 1608
Query: 772 AEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQRE 831
AE + +A+ ++ EG L +E +L A R A + + L++ +
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDL----NEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD 1664
Query: 832 VLRRGKAELEEQKRLLDRTVDRLNKELE-------------KIGE----DSKQALQ---- 870
R + +L+EQ +++R + L E+E KI E D+ + +Q
Sbjct: 1665 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1724
Query: 871 -----------------QLQAQLEDY-------KEKARREVADAQRQAKDWASEAEKTSG 906
Q+Q ++ED +EKA++ + DA A++ E + TS
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQD-TSA 1783
Query: 907 GLSRLQDEIQRLRQALQ-----ASQAERDTARLDKELLAQRLQGLEQEAENKKR------ 955
L R++ +++ + LQ A Q + + L R++ LE E E++++
Sbjct: 1784 HLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843
Query: 956 ----------------SQDDRA--------------------RQLKGLEE-------KVS 972
+++DR RQ + EE K
Sbjct: 1844 KGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFR 1903
Query: 973 RLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQE 1009
+L+ EL+E + ++ +VN+ R + ++ T+++ E
Sbjct: 1904 KLQHELEEAEERADIAESQVNKLRVKSREVHTKVISE 1940
Score = 90.9 bits (224), Expect = 7e-18
Identities = 99/432 (22%), Positives = 193/432 (44%), Gaps = 30/432 (6%)
Query: 735 FRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQ-QLEEALNASQEEEGSLAA 793
F+ +LGL +++++ + L +AR R L R+E ++ + EA+ Q S
Sbjct: 771 FKAGLLGLLEEMRDDK-LAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMN 829
Query: 794 AKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKA---ELEEQKRLLDRT 850
K +L + L + + ++ + EE K ++ L + +A ELEE+ L +
Sbjct: 830 VKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKE 889
Query: 851 VDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSR 910
+ L +++ E A ++ QL K + ++ + +A+D + + +
Sbjct: 890 KNDLQLQVQAEAEGLADAEERCD-QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK 948
Query: 911 LQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEK 970
L+DE L++ + + +K +++ L +E + ++ K L+E
Sbjct: 949 LEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEA 1008
Query: 971 VSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDL 1030
+ +L E++ V LT + QVD L L QE+ R DLE K LE DL
Sbjct: 1009 HQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG---DL 1065
Query: 1031 KTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNR-------KLERKVK 1083
K S+ +E++ Q L E+L+ +E E + LQS +L++K+K
Sbjct: 1066 KLA----------QESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIK 1115
Query: 1084 ELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNE 1143
EL +IE+ + + ++ + R KA K++ D E+E + ++A Q E+N+
Sbjct: 1116 ELQARIEELEEEIEAER---ASRAKAEKQRSD-LSRELEEISERLEEAGGATSAQIEMNK 1171
Query: 1144 QLQARIKSLEKD 1155
+ +A + + +D
Sbjct: 1172 KREAEFQKMRRD 1183
Score = 73.9 bits (180), Expect = 8e-13
Identities = 99/464 (21%), Positives = 187/464 (40%), Gaps = 49/464 (10%)
Query: 770 LEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQ 829
L A+ +Q + LNAS EG +K+A E L ++ + G
Sbjct: 720 LYADFKQRYKVLNASAIPEGQFIDSKKASEKLLASID------------IDHTQYKFGHT 767
Query: 830 REVLRRGKAELEEQKR------LLDRTVDRLNKELEKIG----EDSKQALQQLQAQLEDY 879
+ + G L E+ R L+ RT R L ++ + ++A+ +Q + +
Sbjct: 768 KVFFKAGLLGLLEEMRDDKLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSF 827
Query: 880 KEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERD-------TA 932
+ K AE T ++ +++E Q+++ L S+A+R T
Sbjct: 828 MNVKHWPWMKLFFKIKPLLKSAE-TEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTL 886
Query: 933 RLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRV 992
+K L ++Q + + + D + LE K+ + ++E+ LT +
Sbjct: 887 LKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKK 946
Query: 993 NRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLAS-SEGFQKPSASLSQLE 1051
+ D+ +L+ ++ +E +K + E + K+L +A E K + L+
Sbjct: 947 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1006
Query: 1052 SQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDE---RQHVNDQKDQLSLRVK 1108
+Q + LQAEE + L KLE++V +L +E E R + K +L +K
Sbjct: 1007 EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLK 1066
Query: 1109 ALKRQVDEAEEEIERLDGLRKK-------AQREVEEQHEVNEQLQARIKSL--------E 1153
+ + + E E ++LD KK Q ++E++ + QLQ +IK L E
Sbjct: 1067 LAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEE 1126
Query: 1154 KDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTESN 1197
+ +ASR+ AE + +E + + + S E N
Sbjct: 1127 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN 1170
Score = 70.9 bits (172), Expect = 7e-12
Identities = 84/406 (20%), Positives = 170/406 (41%), Gaps = 30/406 (7%)
Query: 322 LREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELT--------RKVEELQR 373
L+ E+E S+ + +L L V S + +A + E R VE +Q
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQS 1605
Query: 374 KLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQ 433
LD E++ R + +E L E + + + + + L++ + LD
Sbjct: 1606 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD 1665
Query: 434 GEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLE-EVLEGKQRVEEQLRL 492
+ L+ Q+ ++ + +Q L+ +R++ E E+L+ +RV+ L
Sbjct: 1666 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ-LLHT 1724
Query: 493 RERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDAT---------QD-HAV 542
+ L K L+ +++ E+E + Q+ + E+ ++++ DA QD A
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1784
Query: 543 LEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEE 602
LE ++ M V+ LQ L+E Q + K+ ++ + + +L E E ++
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAE------QLALKGGKKQIQKLEARVRELEGEVESEQKR 1838
Query: 603 LGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDREL 662
E ++ L++ + + T Q E +K +LR Q+ + +LQA+ +S + + +
Sbjct: 1839 NAEAVKGLRKHERRVKEL---TYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895
Query: 663 EKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAE 708
LA R E EE+ + + +LR E K+++E
Sbjct: 1896 NTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV-HTKVISE 1940
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 187 bits (476), Expect = 4e-47
Identities = 187/830 (22%), Positives = 372/830 (44%), Gaps = 51/830 (6%)
Query: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 422
EL ++EEL+ +++ E R K E + L R+LEE +E RL+E + + + K
Sbjct: 1116 ELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISE---RLEEAGGATSAQIEMNKK 1172
Query: 423 ---ELQNMKRLLDQGE--------DLRHGLETQVMELQNKLKHVQGP----EPAKEVLLK 467
E Q M+R L++ LR V EL ++ ++Q E K +
Sbjct: 1173 REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKM 1232
Query: 468 DLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTE 527
++ + +E V + K +E+ R E +L+ LK +EE ++ R + Q ++
Sbjct: 1233 EIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSK-EEEQQRLINDLTAQRGRLQTESG 1291
Query: 528 QLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQ 587
+ R + + + L +Q + + L+R+LEE + Q ++ D ++
Sbjct: 1292 EFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLRE 1351
Query: 588 ELLQLRMEKEEMEEELGE-KIEVLQRELEQARASAGDTRQVEVLKKELLR----TQEELK 642
+ + + K E++ L + EV Q + + T ++E KK+L + +E ++
Sbjct: 1352 QYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVE 1411
Query: 643 ELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASK 702
+ A+ S E + E+E + + L+++ K L + +Q CEE
Sbjct: 1412 AVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHA 1471
Query: 703 AKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKE-TRGLVDGGEAVEA 761
++ EA LG ++ E+ ++ + +R L+Q++ + T + +GG+ +
Sbjct: 1472 ELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE 1531
Query: 762 RLRDKLQRLEAEKQQLEEALNASQ----EEEGSLAAAKRALEARLEEAQRGLARLGQEQQ 817
+ K Q +E EK +L+ AL ++ EEG + + L E R +A +E
Sbjct: 1532 LEKIKKQ-VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590
Query: 818 TLNR----ALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQ 873
L R +E + R + + K+ ++ ++ + +L + +AL+ +
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYR 1650
Query: 874 AQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTAR 933
+ + + + DA R +D + + LQ EI+ LR L+ Q ER
Sbjct: 1651 -NTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLE--QTERSRKI 1707
Query: 934 LDKELL--AQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDR 991
++ELL ++R+Q L + + ++ K LE +S+++ E+++ ++
Sbjct: 1708 AEQELLDASERVQLLHTQNTSLINTK-------KKLETDISQMQGEMEDILQEARNAEEK 1760
Query: 992 VNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE--GFQKPSASLSQ 1049
+ + EL +E+ LE K ++E+ KDL+ RL +E + + +
Sbjct: 1761 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQK 1820
Query: 1050 LESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHV---NDQKDQLSLR 1106
LE++ + L+ +++E++ RK ER+VKEL+ Q E++R+++ D D+L +
Sbjct: 1821 LEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAK 1880
Query: 1107 VKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDS 1156
VK+ KRQ +EAEE+ +K Q E+EE E + ++++ L S
Sbjct: 1881 VKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKS 1930
Score = 142 bits (357), Expect = 2e-33
Identities = 199/914 (21%), Positives = 386/914 (42%), Gaps = 155/914 (16%)
Query: 342 EKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTE 401
EKM L+ + V + E EE + D+ +K + +LE + + E++ E
Sbjct: 881 EKMVTLLKEKNDLQLQVQAEAEGLADAEE---RCDQLIKTKIQLEAKIKEVTERAEDEEE 937
Query: 402 ECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPA 461
+ L + + E + K++ +++ L + E +H E +V +N + + G +
Sbjct: 938 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV---KNLTEEMAGLDET 994
Query: 462 KEVLLKDLLETRELLEEVLEGKQRVEEQLRLR-------ERELTALKGALKEEVASRDQE 514
L K+ +E ++ L+ Q E+++ E+++ L+G+L++E R +
Sbjct: 995 IAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLR-MD 1053
Query: 515 VEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSM 574
+E +++ + D + + S+ D + L+ + +K + LQ ++E+
Sbjct: 1054 LERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIED----------- 1102
Query: 575 FQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARAS-AGDTRQVEVLKKE 633
++ L ++++K+ +EL +IE L+ E+E RAS A +Q L +E
Sbjct: 1103 ------------EQALGIQLQKKI--KELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1148
Query: 634 LLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQL 693
L E L+E +Q + R+ E +K R+LEE LQ + T L
Sbjct: 1149 LEEISERLEEAGGATSAQIEMNKKREAEFQKMR----------RDLEEATLQHEATAATL 1198
Query: 694 RQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLV 753
R+ A VAE LG++ ++ ++ ++E E + I L ++
Sbjct: 1199 RK-----KHADSVAE-----LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248
Query: 754 DGGEAVEARLRDKLQRLEAEKQQLEEALN-------ASQEEEGSLAAAKRALEARLEEAQ 806
E + L D+L L++++++ + +N Q E G + EA + +
Sbjct: 1249 GNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLS 1308
Query: 807 RGLARLGQEQQTLNRALEEEGKQR--------------EVLRRGKAELEEQKRLLDRTVD 852
RG Q+ + L R LEEE K + ++LR E +E K L R +
Sbjct: 1309 RGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALS 1368
Query: 853 RLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQ 912
+ N E+ + + Q +LE+ K+K + + A+ + ++ RLQ
Sbjct: 1369 KANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ 1428
Query: 913 DEIQRLRQALQASQAERDTARLDK------ELLAQRLQGLEQEAENKKRSQDDRARQL-- 964
+E++ L L + A LDK ++LA+ Q E+ + SQ + AR L
Sbjct: 1429 NEVEDL--MLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKE-ARSLGT 1485
Query: 965 ------KGLEEKVSRLETELDEEKN---TVELLTDRVNRGRDQV---DQLRTELMQERSA 1012
EE + +LET E KN + LT+++ G ++ ++++ ++ QE+
Sbjct: 1486 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545
Query: 1013 RQ-DLECDKISLE-RQNKDLKTRLASSEGFQKPSASLSQLESQ-NQL----------LQE 1059
Q LE + SLE + K L+ +L ++ + +++ + + +QL +Q
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQS 1605
Query: 1060 RLQAEEREKTVLQSTNRKLERKVKELSIQ---------------------IEDERQHVND 1098
L AE R + +K+E + E+ IQ ++D + H++D
Sbjct: 1606 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD 1665
Query: 1099 Q-------KDQLSL---RVKALKRQVDEAEEEIERLDGLRKKAQRE-------VEEQHEV 1141
K+QL++ R L+ +++E +E+ + RK A++E V+ H
Sbjct: 1666 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1725
Query: 1142 NEQLQARIKSLEKD 1155
N L K LE D
Sbjct: 1726 NTSLINTKKKLETD 1739
Score = 118 bits (295), Expect = 4e-26
Identities = 136/631 (21%), Positives = 292/631 (46%), Gaps = 82/631 (12%)
Query: 571 WQSMFQKNKEDLRA--TKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVE 628
W +F K K L++ T++E+ ++ E +++++EL K E ++ELE+ +
Sbjct: 835 WMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELA-KSEAKRKELEEKMVT-------- 885
Query: 629 VLKKELLRTQEELK-ELQAERQSQEVAGRHRDRELEKQL---AVLRVEADRGRELEEQNL 684
LL+ + +L+ ++QAE + A D+ ++ ++ A ++ +R + EE N
Sbjct: 886 -----LLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINA 940
Query: 685 QLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQ 744
+L ++L +C E K + + E T+ A VE T+ + + GL++
Sbjct: 941 ELTAKKRKLEDECSELKKD--IDDLELTL-----AKVEKEKHATENKVKNLTEEMAGLDE 993
Query: 745 QLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEE 804
+ A+L + + L+ QQ + L A +++ +L AK LE ++++
Sbjct: 994 TI--------------AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD 1039
Query: 805 AQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKEL------ 858
+ L + + + L RA + ++ + ++E +K+ LD + + E+
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSK 1099
Query: 859 ----EKIGEDSKQALQQLQAQLEDYKEKARREVAD---AQRQAKDWASEAEKTS------ 905
+ +G ++ +++LQA++E+ +E+ E A A++Q D + E E+ S
Sbjct: 1100 IEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEA 1159
Query: 906 GGLSRLQDEIQRLRQA-LQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQL 964
GG + Q E+ + R+A Q + + + A L E A L+ ++ + Q D +++
Sbjct: 1160 GGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV 1219
Query: 965 KG-LEEKVSRLETELDEEKNTVELLT------DRVNRG-RDQVDQLRTELMQERSARQDL 1016
K LE++ S ++ E+D+ + VE ++ +++ R DQ+ +L+++ +++ DL
Sbjct: 1220 KQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDL 1279
Query: 1017 ECDKISLERQNKDLKTRLASSEGF-----QKPSASLSQLESQNQLLQERLQAEEREKTVL 1071
+ L+ ++ + +L E + A Q+E + L+E ++A+ L
Sbjct: 1280 TAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHAL 1339
Query: 1072 QSTNRKLERKVKELSIQIEDERQHVNDQKDQLS---LRVKALKRQVD-EAEEEIERLDGL 1127
QS+ + L Q E+E++ + + LS V + + + +A + E L+
Sbjct: 1340 QSSRHDCDL----LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEA 1395
Query: 1128 RKKAQREVEEQHEVNEQLQARIKSLEKDSWR 1158
+KK + ++ E E + A+ SLEK R
Sbjct: 1396 KKKLAQRLQAAEEHVEAVNAKCASLEKTKQR 1426
Score = 117 bits (292), Expect = 9e-26
Identities = 170/817 (20%), Positives = 335/817 (41%), Gaps = 176/817 (21%)
Query: 356 KAVAGQGELTRKVEELQRKLDE-------EVKKRQKLEPSQVGLERQLEEKTEECSRLQE 408
KA + +L+R++EE+ +L+E +++ +K E + R LEE T +
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196
Query: 409 LLERRKGEA-QQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLK 467
L ++ ++ + +++ N++R+ + E + ++ ME+ + +V+ AK L K
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK---MEIDDLASNVETVSKAKGNLEK 1253
Query: 468 DLLETRELLEEVLEGKQRVEEQLRLRERELTALKGAL-------------KEEVASR--- 511
R L +++ E K + EEQ RL +LTA +G L KE + S+
Sbjct: 1254 ---MCRTLEDQLSELKSKEEEQQRLIN-DLTAQRGRLQTESGEFSRQLDEKEALVSQLSR 1309
Query: 512 -----DQEVEHVRQQYQRDTEQ---LRRSMQDATQDHAVLEAERQKMSALVRGLQRELEE 563
Q++E +++Q + + + L ++Q + D +L + ++ LQR L +
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369
Query: 564 TSEETGHWQSMFQ----KNKEDLRATKQELLQLRMEKEEMEEELGEKI-------EVLQR 612
+ E W++ ++ + E+L K++L Q EE E + K + LQ
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQN 1429
Query: 613 ELEQ---------ARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELE 663
E+E A +A D +Q K L +++ +E AE ++ + R EL
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRN-FDKILAEWKQKCEETHAELEASQKEARSLGTELF 1488
Query: 664 KQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVET 723
K D+ L+ +N LQ+ + L + E K E + Q + ++
Sbjct: 1489 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA 1548
Query: 724 TLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQR------------LE 771
L E + + +IL ++ +L + + VD A + D+L+R L+
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD 1608
Query: 772 AEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQRE 831
AE + +A+ ++ EG L +E +L A R A + + L++ +
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDL----NEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD 1664
Query: 832 VLRRGKAELEEQKRLLDRTVDRLNKELE-------------KIGE----DSKQALQ---- 870
R + +L+EQ +++R + L E+E KI E D+ + +Q
Sbjct: 1665 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1724
Query: 871 -----------------QLQAQLEDY-------KEKARREVADAQRQAKDWASEAEKTSG 906
Q+Q ++ED +EKA++ + DA A++ E + TS
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQD-TSA 1783
Query: 907 GLSRLQDEIQRLRQALQ-----ASQAERDTARLDKELLAQRLQGLEQEAENKKR------ 955
L R++ +++ + LQ A Q + + L R++ LE E E++++
Sbjct: 1784 HLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843
Query: 956 ----------------SQDDRA--------------------RQLKGLEE-------KVS 972
+++DR RQ + EE K
Sbjct: 1844 KGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFR 1903
Query: 973 RLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQE 1009
+L+ EL+E + ++ +VN+ R + ++ T+++ E
Sbjct: 1904 KLQHELEEAEERADIAESQVNKLRVKSREVHTKVISE 1940
Score = 90.9 bits (224), Expect = 7e-18
Identities = 99/432 (22%), Positives = 193/432 (44%), Gaps = 30/432 (6%)
Query: 735 FRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQ-QLEEALNASQEEEGSLAA 793
F+ +LGL +++++ + L +AR R L R+E ++ + EA+ Q S
Sbjct: 771 FKAGLLGLLEEMRDDK-LAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMN 829
Query: 794 AKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKA---ELEEQKRLLDRT 850
K +L + L + + ++ + EE K ++ L + +A ELEE+ L +
Sbjct: 830 VKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKE 889
Query: 851 VDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSR 910
+ L +++ E A ++ QL K + ++ + +A+D + + +
Sbjct: 890 KNDLQLQVQAEAEGLADAEERCD-QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK 948
Query: 911 LQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEK 970
L+DE L++ + + +K +++ L +E + ++ K L+E
Sbjct: 949 LEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEA 1008
Query: 971 VSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDL 1030
+ +L E++ V LT + QVD L L QE+ R DLE K LE DL
Sbjct: 1009 HQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG---DL 1065
Query: 1031 KTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNR-------KLERKVK 1083
K S+ +E++ Q L E+L+ +E E + LQS +L++K+K
Sbjct: 1066 KLA----------QESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIK 1115
Query: 1084 ELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNE 1143
EL +IE+ + + ++ + R KA K++ D E+E + ++A Q E+N+
Sbjct: 1116 ELQARIEELEEEIEAER---ASRAKAEKQRSD-LSRELEEISERLEEAGGATSAQIEMNK 1171
Query: 1144 QLQARIKSLEKD 1155
+ +A + + +D
Sbjct: 1172 KREAEFQKMRRD 1183
Score = 73.9 bits (180), Expect = 8e-13
Identities = 99/464 (21%), Positives = 187/464 (40%), Gaps = 49/464 (10%)
Query: 770 LEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQ 829
L A+ +Q + LNAS EG +K+A E L ++ + G
Sbjct: 720 LYADFKQRYKVLNASAIPEGQFIDSKKASEKLLASID------------IDHTQYKFGHT 767
Query: 830 REVLRRGKAELEEQKR------LLDRTVDRLNKELEKIG----EDSKQALQQLQAQLEDY 879
+ + G L E+ R L+ RT R L ++ + ++A+ +Q + +
Sbjct: 768 KVFFKAGLLGLLEEMRDDKLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSF 827
Query: 880 KEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERD-------TA 932
+ K AE T ++ +++E Q+++ L S+A+R T
Sbjct: 828 MNVKHWPWMKLFFKIKPLLKSAE-TEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTL 886
Query: 933 RLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRV 992
+K L ++Q + + + D + LE K+ + ++E+ LT +
Sbjct: 887 LKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKK 946
Query: 993 NRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLAS-SEGFQKPSASLSQLE 1051
+ D+ +L+ ++ +E +K + E + K+L +A E K + L+
Sbjct: 947 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1006
Query: 1052 SQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDE---RQHVNDQKDQLSLRVK 1108
+Q + LQAEE + L KLE++V +L +E E R + K +L +K
Sbjct: 1007 EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLK 1066
Query: 1109 ALKRQVDEAEEEIERLDGLRKK-------AQREVEEQHEVNEQLQARIKSL--------E 1153
+ + + E E ++LD KK Q ++E++ + QLQ +IK L E
Sbjct: 1067 LAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEE 1126
Query: 1154 KDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTESN 1197
+ +ASR+ AE + +E + + + S E N
Sbjct: 1127 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN 1170
Score = 70.9 bits (172), Expect = 7e-12
Identities = 84/406 (20%), Positives = 170/406 (41%), Gaps = 30/406 (7%)
Query: 322 LREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELT--------RKVEELQR 373
L+ E+E S+ + +L L V S + +A + E R VE +Q
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQS 1605
Query: 374 KLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQ 433
LD E++ R + +E L E + + + + + L++ + LD
Sbjct: 1606 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD 1665
Query: 434 GEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLE-EVLEGKQRVEEQLRL 492
+ L+ Q+ ++ + +Q L+ +R++ E E+L+ +RV+ L
Sbjct: 1666 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ-LLHT 1724
Query: 493 RERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDAT---------QD-HAV 542
+ L K L+ +++ E+E + Q+ + E+ ++++ DA QD A
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1784
Query: 543 LEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEE 602
LE ++ M V+ LQ L+E Q + K+ ++ + + +L E E ++
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAE------QLALKGGKKQIQKLEARVRELEGEVESEQKR 1838
Query: 603 LGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDREL 662
E ++ L++ + + T Q E +K +LR Q+ + +LQA+ +S + + +
Sbjct: 1839 NAEAVKGLRKHERRVKEL---TYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895
Query: 663 EKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAE 708
LA R E EE+ + + +LR E K+++E
Sbjct: 1896 NTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV-HTKVISE 1940
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 186 bits (473), Expect = 9e-47
Identities = 192/834 (23%), Positives = 374/834 (44%), Gaps = 67/834 (8%)
Query: 367 KVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK---E 423
++EEL+ +L+ E R K+E + L R+LEE +E RL+E + + + K E
Sbjct: 1116 RIEELEEELEAERTARAKVEKLRSDLSRELEEISE---RLEEAGGATSVQIEMNKKREAE 1172
Query: 424 LQNMKRLLDQGE--------DLRHGLETQVMELQNKLKHVQGP----EPAKEVLLKDLLE 471
Q M+R L++ LR V EL ++ ++Q E K +L +
Sbjct: 1173 FQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDD 1232
Query: 472 TRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRR 531
+E++++ K +E+ R E + + L+E S + R + Q + +L R
Sbjct: 1233 VTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQ-RAKLQTENGELAR 1291
Query: 532 SMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQ 591
+++ + L + + + L+R+LEE + Q + D +++ +
Sbjct: 1292 QLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEE 1351
Query: 592 LRMEKEEMEEELGE-KIEVLQRELEQARASAGDTRQVEVLKKEL---LRTQEELKELQAE 647
K E++ L + EV Q + + T ++E KK+L L+ EE E
Sbjct: 1352 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNA 1411
Query: 648 RQSQEVAGRHRDRELEKQLAVLRVEADRGRE----LEEQNLQLQKTLQQLRQDCEEASKA 703
+ S +HR L+ ++ L V+ +R L+++ K L + +Q EE+
Sbjct: 1412 KCSSLEKTKHR---LQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1468
Query: 704 KMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKE-TRGLVDGGEAVEAR 762
++ EA L ++ E+ E + F+R L++++ + T L +GG+ V
Sbjct: 1469 LESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVH-E 1527
Query: 763 LRDKLQRLEAEKQQLEEALNASQ----EEEGSLAAAKRALEARLEEAQRGLARLGQEQQ- 817
L ++LE EK +L+ AL ++ EEG + A+ E +R LA +E +
Sbjct: 1528 LEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 1587
Query: 818 ----------TLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQ 867
+L +L+ E + R + R K ++E ++ + N+ + ++++
Sbjct: 1588 AKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANR----MAAEAQK 1643
Query: 868 ALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQA 927
++ LQ+ L+D + ++ DA R D + LQ E++ LR ++ ++
Sbjct: 1644 QVKSLQSLLKD----TQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTER 1699
Query: 928 ERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVEL 987
R A + ++R+Q L + Q K +E +++L++E++E
Sbjct: 1700 SRKLAEQELIETSERVQLLHSQ-------NTSLINQKKKMESDLTQLQSEVEEAVQECRN 1752
Query: 988 LTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE--GFQKPSA 1045
++ + + EL +E+ LE K ++E+ KDL+ RL +E +
Sbjct: 1753 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1812
Query: 1046 SLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQH---VNDQKDQ 1102
L +LE++ + L+ L+AE++ RK ER++KEL+ Q E+++++ + D D+
Sbjct: 1813 QLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDK 1872
Query: 1103 LSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDS 1156
L L+VKA KRQ +EAEE+ +K Q E++E E + ++++ L S
Sbjct: 1873 LQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKS 1926
Score = 168 bits (426), Expect = 2e-41
Identities = 202/896 (22%), Positives = 382/896 (42%), Gaps = 135/896 (15%)
Query: 319 YGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEE 378
+G ++E +SE RRK + EKM L+ + V + + EE + D+
Sbjct: 858 FGRIKETLEKSEA--RRKE--LEEKMVSLLQEKNDLQLQVQAEQDNLNDAEE---RCDQL 910
Query: 379 VKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLR 438
+K + +LE + +LE++ E + L + + E + K++ +++ L + E +
Sbjct: 911 IKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEK 970
Query: 439 HGLETQVMELQNKL-----------KHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVE 487
H E +V L ++ K + + A + L DL + + + + K ++E
Sbjct: 971 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLE 1030
Query: 488 EQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAER 547
+Q+ L+G+L++E R ++E +++ + D + + S+ D D LE +
Sbjct: 1031 QQV-------DDLEGSLEQEKKVR-MDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKL 1082
Query: 548 QKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKI 607
+K F N+++ + +++L L+++K+ E + +I
Sbjct: 1083 KKKE-----------------------FDINQQNSKIEDEQVLALQLQKKLKENQA--RI 1117
Query: 608 EVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLA 667
E L+ ELE R + +VE L+ +L R EE+ E E +++ E +
Sbjct: 1118 EELEEELEAERTARA---KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ 1174
Query: 668 VLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRE 727
+R R+LEE LQ + T LR+ A VAE LG++ ++ ++
Sbjct: 1175 KMR------RDLEEATLQHEATAAALRK-----KHADSVAE-----LGEQIDNLQRVKQK 1218
Query: 728 TQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALN----- 782
++E EF+ + + +++ E V L D+ + ++ + +LN
Sbjct: 1219 LEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQ 1278
Query: 783 --ASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQR---------- 830
Q E G LA EA + + RG Q+ + L R LEEEGK +
Sbjct: 1279 RAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSA 1338
Query: 831 ----EVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARRE 886
++LR E E K L R + + N E+ + + Q +LE+ K+K +
Sbjct: 1339 RHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1398
Query: 887 VADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDK------ELLA 940
+ DA+ + ++ RLQ+EI+ L ++ S A A LDK ++LA
Sbjct: 1399 LQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA--AAALDKKQRNFDKILA 1456
Query: 941 QRLQGLEQEAENKKRSQDDRARQL--------KGLEEKVSRLETELDEEKNTVEL---LT 989
+ Q E E++++ S AR L EE + LET E KN E LT
Sbjct: 1457 EWKQKYE-ESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLT 1515
Query: 990 DRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQ 1049
+++ G V +L R+ LE +K+ L+ ++ + L EG +Q
Sbjct: 1516 EQLGEGGKNVHEL-------EKVRKQLEVEKLELQSALEEAEASLEHEEG----KILRAQ 1564
Query: 1050 LE-SQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVND---------- 1098
LE +Q + ER AE+ E+ ++ R +R V L ++ E + N+
Sbjct: 1565 LEFNQIKAEIERKLAEKDEE--MEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEG 1622
Query: 1099 QKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEK 1154
+++ +++ R EA+++++ L L K Q ++++ N+ L+ I +E+
Sbjct: 1623 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVER 1678
Score = 120 bits (302), Expect = 6e-27
Identities = 155/770 (20%), Positives = 323/770 (41%), Gaps = 86/770 (11%)
Query: 160 APKVASPGSTIDTAPLSSVDSLINKFDSQLGGQARGRTGRRTRMLPPEQR--KRSKSLDS 217
A VA G ID L V + K S+ + T +++ + K S++L+
Sbjct: 1199 ADSVAELGEQIDN--LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLED 1256
Query: 218 RLP--RDTFEERERQSTNHWTSSTKYDNHVGTSKQPAQSQN--LSPLSG--FSRSRQTQD 271
+ R EE +R + T K G + + + +S L+ S ++Q +D
Sbjct: 1257 QANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMED 1316
Query: 272 WVLQSFEEPR-RSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSES- 329
Q EE + ++A + + DLLR+Q E KA + +L + +SE
Sbjct: 1317 LKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEA-----KAELQRVLSKANSEVA 1371
Query: 330 ------ETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQ 383
ET ++ + E + L + +AV +E+ + +L E++
Sbjct: 1372 QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1431
Query: 384 -----------KLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLD 432
L+ Q ++ L E ++ Q LE + EA+ + EL +K +
Sbjct: 1432 VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE 1491
Query: 433 QGEDLRH---------GLETQVMELQNKL----KHVQGPEPAKEVLLKDLLETRELLEEV 479
E L H L+ ++ +L +L K+V E ++ L + LE + LEE
Sbjct: 1492 --ESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEA 1549
Query: 480 LEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQD 539
+ E ++ + E +K ++ ++A +D+E+E ++ +QR + L+ S+ T+
Sbjct: 1550 EASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRS 1609
Query: 540 HAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEM 599
+ ++KM + ++ +L + Q + + L+ T+ +L +++
Sbjct: 1610 RNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1669
Query: 600 EEELG---EKIEVLQRELEQARASAGDT-RQVEVLKKELLRTQEELKELQAERQSQEVAG 655
+E + + +LQ ELE+ RA T R ++ ++EL+ T E ++ L ++ S
Sbjct: 1670 KENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL---- 1725
Query: 656 RHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLG 715
++ +++E QLQ +++ Q+C A + A +A ++
Sbjct: 1726 -----------------INQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMA 1768
Query: 716 QRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEAR-LRDKLQRLEAEK 774
+ L++ Q+ + R +EQ +K+ + +D E + + + +LQ+LEA
Sbjct: 1769 EE-------LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARV 1821
Query: 775 QQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLR 834
++LE L A Q+ R E R++E + ++++ L R + K + ++
Sbjct: 1822 RELEGELEAEQKRNAESVKGMRKSERRIKEL---TYQTEEDKKNLLRLQDLVDKLQLKVK 1878
Query: 835 RGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKAR 884
K + EE + + + + K ++ E ++A ++Q+ + K+R
Sbjct: 1879 AYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA-DIAESQVNKLRAKSR 1927
Score = 109 bits (273), Expect = 1e-23
Identities = 152/731 (20%), Positives = 289/731 (39%), Gaps = 131/731 (17%)
Query: 558 QRELEETSEETGHWQSMFQ----------------------------------------- 576
++E+ EE G + +
Sbjct: 848 EKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERC 907
Query: 577 ----KNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTR-QVEVLK 631
KNK L A +E+ + ++EEM EL K L+ E + + D + ++
Sbjct: 908 DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVE 967
Query: 632 KELLRTQEELKELQAERQSQE--VAGRHRDREL-----EKQLAVLRVEADRGRELEEQNL 684
KE T+ ++K L E + +A ++++ ++ L L+VE D+ L + +
Sbjct: 968 KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKV 1027
Query: 685 QLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQ 744
+L++ + L E+ K +M E + + +E L+ TQE + L LE+
Sbjct: 1028 KLEQQVDDLEGSLEQEKKVRMDLE-------RAKRKLEGDLKLTQESIMDLENDKLQLEE 1080
Query: 745 QLK-------ETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRA 797
+LK + ++ + + +L+ KL+ +A ++LEE L A + + +
Sbjct: 1081 KLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSD 1140
Query: 798 LEARLEEAQRGLARLG--------------QEQQTLNRALEEE----------------- 826
L LEE L G E Q + R LEE
Sbjct: 1141 LSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD 1200
Query: 827 -----GKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKE 881
G+Q + L+R K +LE++K +D + +E+I + +K L+++ LED
Sbjct: 1201 SVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIK-AKANLEKVSRTLEDQAN 1259
Query: 882 KARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQ 941
+ R ++ +AQR D+ ++ K LQ E L + L+ +A K Q
Sbjct: 1260 EYRVKLEEAQRSLNDFTTQRAK-------LQTENGELARQLEEKEALISQLTRGKLSYTQ 1312
Query: 942 RLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQ 1001
+++ L+++ E + ++++ A L+ L + +EE L +++ +V Q
Sbjct: 1313 QMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ 1372
Query: 1002 LRTELMQERSARQDLECDKISLERQNKDLKTRLA-SSEGFQKPSASLSQLESQNQLLQER 1060
RT+ + R + LE K L RL + E + +A S LE LQ
Sbjct: 1373 WRTKYETDAIQRTE------ELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNE 1426
Query: 1061 L-------QAEEREKTVLQSTNRKLERKVKELSIQIEDERQHV-NDQKDQLSLRVKALKR 1112
+ + L R ++ + E + E+ + + + QK+ SL + K
Sbjct: 1427 IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1486
Query: 1113 QVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSL-EKDSWRK---ASRSAAESA 1168
+ + EE +E L+ +++ + EE ++ EQL K++ E + RK + +SA
Sbjct: 1487 K-NAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSA 1545
Query: 1169 LKNEGLSSDEE 1179
L+ S + E
Sbjct: 1546 LEEAEASLEHE 1556
Score = 100 bits (248), Expect = 1e-20
Identities = 131/592 (22%), Positives = 252/592 (42%), Gaps = 103/592 (17%)
Query: 658 RDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDC-EEASKAKMVAEAEATVLGQ 716
+ E EK++A ++ E R +E E++ +K L++ +E + ++ +AE
Sbjct: 843 KSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAE------ 896
Query: 717 RRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQ 776
+ L + +E D+ + + LE ++KE ++ E + A L K ++LE E +
Sbjct: 897 -----QDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSE 951
Query: 777 LEEAL----------------------NASQEEEG------SLAAAKRAL---------- 798
L++ + N ++E G L K+AL
Sbjct: 952 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDD 1011
Query: 799 ----EARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELE-----EQKRLLDR 849
E ++ + +L Q+ L +LE+E K R L R K +LE Q+ ++D
Sbjct: 1012 LQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1071
Query: 850 TVDRL-------------NKELEKIGEDSKQALQ------QLQAQLEDYKEKARRE---V 887
D+L N++ KI ++ ALQ + QA++E+ +E+ E
Sbjct: 1072 ENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTAR 1131
Query: 888 ADAQRQAKDWASEAEKTS------GGLSRLQDEIQRLRQA-LQASQAERDTARLDKELLA 940
A ++ D + E E+ S GG + +Q E+ + R+A Q + + + A L E A
Sbjct: 1132 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATA 1191
Query: 941 QRLQGLEQEAENKKRSQDDRARQLK-GLEEKVSRLETELDEEKNTVELL------TDRVN 993
L+ ++ + Q D +++K LE++ S + ELD+ + +E + ++V+
Sbjct: 1192 AALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVS 1251
Query: 994 RG-RDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGF--QKPSASLSQL 1050
R DQ ++ R +L + + + D + L+ +N +L +L E Q LS
Sbjct: 1252 RTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYT 1311
Query: 1051 ESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKAL 1110
+ Q + L+ +L+ E + K L + L Q E+E + + + LS +
Sbjct: 1312 Q-QMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEV 1370
Query: 1111 ----KRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWR 1158
+ +A + E L+ +KK + +++ E E + A+ SLEK R
Sbjct: 1371 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHR 1422
Score = 69.3 bits (168), Expect = 2e-11
Identities = 86/402 (21%), Positives = 171/402 (42%), Gaps = 26/402 (6%)
Query: 322 LREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELT--------RKVEELQR 373
L+ E+E S+ + +L + + + +A + E R V+ LQ
Sbjct: 1542 LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQT 1601
Query: 374 KLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKR---- 429
LD E + R ++ + +E L E + S R EAQ+ K LQ++ +
Sbjct: 1602 SLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHAN----RMAAEAQKQVKSLQSLLKDTQI 1657
Query: 430 LLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLE-EVLEGKQRVEE 488
LD L+ + ++ + +Q +++ +R+L E E++E +RV+
Sbjct: 1658 QLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQ- 1716
Query: 489 QLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQ 548
L + L K ++ ++ EVE Q+ + E+ ++++ DA L+ E Q
Sbjct: 1717 LLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKE-Q 1775
Query: 549 KMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIE 608
SA + +++ +E+T ++ H + + + L+ K++L +L E+E EL + +
Sbjct: 1776 DTSAHLERMKKNMEQTIKDLQH--RLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQK 1833
Query: 609 VLQRELEQARASAGD----TRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEK 664
++ R S T Q E KK LLR Q+ + +LQ + ++ + + +
Sbjct: 1834 RNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANT 1893
Query: 665 QLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE-ASKAKM 705
L+ R E EE+ + + +LR + +K KM
Sbjct: 1894 NLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKQKM 1935
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 186 bits (473), Expect = 9e-47
Identities = 225/1008 (22%), Positives = 450/1008 (44%), Gaps = 114/1008 (11%)
Query: 215 LDSRLPRDTFEERERQSTNHWT----SSTKYDNHVGTSKQPAQSQNLSPLSGFSRSRQTQ 270
LD + + + E++ Q T+ T + + ++ T + Q + L G S + +
Sbjct: 988 LDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEG---SLEQE 1044
Query: 271 DWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSES- 329
+ E +R + L +ST D+ D+Q+ ++ + I ++ + E
Sbjct: 1045 KKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDE--KLEKKEFEISNLISKIEDEQA 1102
Query: 330 -ETSVRRKVSLVLEKMQPL----VMVSSGSTKAVAGQGELTRKVEELQRKLDE------- 377
E +++K+ + +++ L + KA + +L+R++EE+ +L+E
Sbjct: 1103 VEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSA 1162
Query: 378 EVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQ-QSNKELQNMKRLLDQGED 436
+V+ +K E L R LEE T + + L ++ ++ + +++ N++R+ + E
Sbjct: 1163 QVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEK 1222
Query: 437 LRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERE 496
+ L+ + +L + + + + E + R L ++V E K + EEQ RL +
Sbjct: 1223 EKSELKMETDDLSSNAEAISKAKGNLEKMC------RSLEDQVSELKTKEEEQQRLIN-D 1275
Query: 497 LTALKGALKEEVASRDQEVEHVRQQYQRDT--EQLRRSMQDATQDHAVLEAERQKMSALV 554
LTA + L+ E E+ RQ ++D QL RS Q +TQ +
Sbjct: 1276 LTAQRARLQTEAG------EYSRQLDEKDALVSQLSRSKQASTQQ--------------I 1315
Query: 555 RGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGE-KIEVLQRE 613
L+ +LEE ++ Q ++ D +++ + + K E++ L + EV Q
Sbjct: 1316 EELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWR 1375
Query: 614 LEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRE-LEKQLAVLRVE 672
+ + T ++E KK+L + +E +E E + + A + ++ L+ ++ L ++
Sbjct: 1376 TKYETDAIQRTEELEEAKKKLAQRLQEAEE-HVEAVNAKCASLEKTKQRLQNEVEDLMLD 1434
Query: 673 ADRGRE----LEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRET 728
+R L+++ K L + +Q EE ++ E+ L V+ E+
Sbjct: 1435 VERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEES 1494
Query: 729 QEENDEFRRRILGLEQQLKE-TRGLVDGGEAVEARLRDKLQRLEAEKQQ----LEEALNA 783
++ + RR L+Q++ + T + +GG+ + + K Q +E EK + LEEA +
Sbjct: 1495 LDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQ-VEQEKCEIQAALEEAEAS 1553
Query: 784 SQEEEGSLAAAKRALEARLEEAQRGLARLGQE---------------QQTLNRALEEEGK 828
+ EEG + + L E R +A +E Q TL+ +
Sbjct: 1554 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRND 1613
Query: 829 QREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDY---KEKARR 885
V ++ + +L E + L+ +RL E + +++ L++ Q L+D +E +
Sbjct: 1614 ALRVKKKMEGDLNEMEIQLNHA-NRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKE 1672
Query: 886 EVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELL--AQRL 943
++A +R+A + LQ EI+ L L+ Q ER ++ELL ++R+
Sbjct: 1673 QLAIVERRA--------------NLLQAEIEELWATLE--QTERSRKIAEQELLDASERV 1716
Query: 944 QGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLR 1003
Q L + + ++ K LE VS+L++E++E ++ + +
Sbjct: 1717 QLLHTQNTSLINTK-------KKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMA 1769
Query: 1004 TELMQERSARQDLECDKISLERQNKDLKTRLASSE--GFQKPSASLSQLESQNQLLQERL 1061
EL +E+ LE K +LE+ KDL+ RL +E + + +LE++ + L+ +
Sbjct: 1770 EELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEV 1829
Query: 1062 QAEEREKTVLQSTNRKLERKVKELSIQIEDERQHV---NDQKDQLSLRVKALKRQVDEAE 1118
+ E++ RK ER+VKEL+ Q E++R++V D D+L +VK+ KRQ +EAE
Sbjct: 1830 ENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAE 1889
Query: 1119 EEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAE 1166
E+ +K Q E+EE E + ++++ L S ++ +AE
Sbjct: 1890 EQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKISAE 1937
Score = 140 bits (352), Expect = 9e-33
Identities = 201/941 (21%), Positives = 405/941 (43%), Gaps = 136/941 (14%)
Query: 361 QGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQEL-----LERRK- 414
+ +L +V+ L + ++ ++L +++ LE +++E TE +E+ ++RK
Sbjct: 887 KNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKL 946
Query: 415 -GEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETR 473
E + K++ +++ L + E +H E +V +N + + G + L K+ +
Sbjct: 947 EDECSELKKDIDDLELTLAKVEKEKHATENKV---KNLTEEMAGLDETIAKLSKEKKALQ 1003
Query: 474 ELLEEVLEGKQRVEEQLRLR-------ERELTALKGALKEEVASRDQEVEHVRQQYQRDT 526
E ++ L+ Q E+++ + E+++ L+G+L++E R ++E +++ + D
Sbjct: 1004 ETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLR-MDLERAKRKLEGDL 1062
Query: 527 EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATK 586
+ + S D D L+ + +K + L ++E+ + QK ++L+A
Sbjct: 1063 KLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAV----EIQLQKKIKELQARI 1118
Query: 587 QELLQ-------LRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQE 639
+EL + R + E+ +L ++E + LE+A + + QVE+ KK +
Sbjct: 1119 EELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT--SAQVELNKKR----EA 1172
Query: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVE-ADRGRELEEQNLQLQKTLQQLRQDCE 698
E ++L+ R +E +H E +A LR + AD EL EQ LQ+ Q+L ++
Sbjct: 1173 EFQKLR--RDLEEATLQH-----EAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKS 1225
Query: 699 EASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEA 758
E + A + + + +E R +++ E L+ + +E + L++ A
Sbjct: 1226 ELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSE-------LKTKEEEQQRLINDLTA 1278
Query: 759 VEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQT 818
ARL + E + L+ L+ +K+A ++EE + L + +
Sbjct: 1279 QRARL-------QTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNA 1331
Query: 819 LNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLED 878
L AL+ ++LR E +E K L R + + N E+ + + Q +LE+
Sbjct: 1332 LAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEE 1391
Query: 879 YKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQA-----ERDTAR 933
K+K + + +A+ + ++ RLQ+E++ L ++ S A ++
Sbjct: 1392 AKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRN 1451
Query: 934 LDKELLAQRLQGLEQEAE-----NKKRSQDDRARQLKGL-EEKVSRLETELDEEKN---T 984
DK L + + E +AE + RS ++K + EE + +LET E KN
Sbjct: 1452 FDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQE 1511
Query: 985 VELLTDRVNRGRDQV---DQLRTELMQERSARQ-DLECDKISLE-RQNKDLKTRLASSE- 1038
+ LT+++ G Q+ ++++ ++ QE+ Q LE + SLE + K L+ +L ++
Sbjct: 1512 ISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQV 1571
Query: 1039 ------GFQKPSASLSQLESQN----QLLQERLQAEEREKTVLQSTNRKLERKVKELSIQ 1088
+ + QL+ + + +Q L AE R + +K+E + E+ IQ
Sbjct: 1572 KSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQ 1631
Query: 1089 ----------------------------IEDERQHVNDQKDQLSL---RVKALKRQVDEA 1117
++D + D K+QL++ R L+ +++E
Sbjct: 1632 LNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEEL 1691
Query: 1118 EEEIERLDGLRKKAQRE-------VEEQHEVNEQLQARIKSLEKDSWR---------KAS 1161
+E+ + RK A++E V+ H N L K LE D + + S
Sbjct: 1692 WATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQES 1751
Query: 1162 RSAAESALK--NEGLSSDEEFDSVYDPSSIASLLTESNLQT 1200
R+A E A K + EE D S+ + ++ QT
Sbjct: 1752 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT 1792
Score = 103 bits (256), Expect = 1e-21
Identities = 119/507 (23%), Positives = 227/507 (44%), Gaps = 62/507 (12%)
Query: 684 LQLQKTLQQLRQDCEEASKAK-MVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGL 742
L+ +T +++ EE K K +A++EA +R+ E + +E+ND L L
Sbjct: 843 LKSAETEKEMATMKEEFQKTKDELAKSEA----KRKELEEKMVTLLKEKND------LQL 892
Query: 743 EQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARL 802
+ Q E L D E E +++K+Q LEA+ +++ E +E L A KR LE
Sbjct: 893 QVQ-SEADSLADAEERCEQLIKNKIQ-LEAKIKEVTERAEEEEEINAELTAKKRKLEDEC 950
Query: 803 EEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIG 862
E ++ + L L + K++ L E+ LD T+ +L+KE + +
Sbjct: 951 SELKKDI-------DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQ 1003
Query: 863 EDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQAL 922
E +Q L LQA+ ED + ++Q D E+ L+ ++L L
Sbjct: 1004 ETHQQTLDDLQAE-EDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL 1062
Query: 923 QASQAERDTARLDKELLAQRLQGLEQEAENK-KRSQDDRA------RQLKGLEEKVSRLE 975
+ +Q DK+ L ++L+ E E N + +D++A +++K L+ ++ L
Sbjct: 1063 KLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELG 1122
Query: 976 TELDEEKNT---VELLTDRVNRGRDQVDQ----------LRTELMQERSA-----RQDLE 1017
E++ E+ + E ++R +++ + + EL ++R A R+DLE
Sbjct: 1123 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLE 1182
Query: 1018 CDKISLERQNKDLKTRLASSEG------------FQKPSASLSQLESQNQLLQERLQAEE 1065
+ E L+ + A S QK S+L+ + L +A
Sbjct: 1183 EATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAIS 1242
Query: 1066 REKTVLQSTNRKLERKVKELSIQIEDERQHVND---QKDQLSLRVKALKRQVDEAEEEIE 1122
+ K L+ R LE +V EL + E++++ +ND Q+ +L RQ+DE + +
Sbjct: 1243 KAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVS 1302
Query: 1123 RLDGLRKKAQREVEE-QHEVNEQLQAR 1148
+L ++ + +++EE +H++ E+ +A+
Sbjct: 1303 QLSRSKQASTQQIEELKHQLEEETKAK 1329
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 186 bits (472), Expect = 1e-46
Identities = 191/834 (22%), Positives = 379/834 (45%), Gaps = 67/834 (8%)
Query: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEEC-------SRLQELLERRKG 415
EL ++EEL+ +++ E R K E + R+LEE +E S EL ++R+
Sbjct: 1111 ELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREA 1170
Query: 416 EAQQSNKELQN--------MKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLK 467
E + ++L+ + L + D L Q+ LQ + ++ + ++ +
Sbjct: 1171 EFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEID 1230
Query: 468 DLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTE 527
DL + +E V + K +E+ R E +L+ +G EE+ E+ + + Q +
Sbjct: 1231 DLSSS---MESVSKSKANLEKICRTLEDQLSEARGK-NEEIQRSLSELTTQKSRLQTEAG 1286
Query: 528 QLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQ 587
+L R +++ + L +Q + L+R+LEE ++ Q ++ D ++
Sbjct: 1287 ELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLRE 1346
Query: 588 ELLQLRMEKEEMEEELGE-KIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQA 646
+ + + K E++ L + EV Q + + T ++E KK+L + ++ +E Q
Sbjct: 1347 QYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEE-QV 1405
Query: 647 ERQSQEVAGRHRDRE-LEKQLAVLRVEADRGREL----EEQNLQLQKTLQQLRQDCEEAS 701
E + + A + ++ L+ ++ L V+ +R L +++ K L + + CEE+
Sbjct: 1406 EAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQ 1465
Query: 702 KAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKE-TRGLVDGGEAVE 760
+ E+ L ++ E ++ + +R LEQ++ + T + + G+ +
Sbjct: 1466 AELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIH 1525
Query: 761 ARLRDKLQRLEAEKQQ----LEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQ 816
L +++E EK LEEA A + EE + + L E R +A +E
Sbjct: 1526 -ELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEI 1584
Query: 817 QTLNR-----------ALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDS 865
+ L R AL+ E + R R K ++E ++ + N++ ++
Sbjct: 1585 EQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQ----AAET 1640
Query: 866 KQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQAS 925
+ L+ +Q QL+D + + DA R +D + + LQ E++ LR L+
Sbjct: 1641 LKHLRSVQGQLKD----TQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLE-- 1694
Query: 926 QAERDTARLDKELLA--QRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKN 983
Q ER ++ELL +R+Q L + + ++ K LE + +L++E+++
Sbjct: 1695 QTERARKLAEQELLDSNERVQLLHTQNTSLIHTK-------KKLETDLMQLQSEVEDASR 1747
Query: 984 TVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE--GFQ 1041
++ + + EL +E+ LE K +LE+ KDL+ RL +E +
Sbjct: 1748 DARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK 1807
Query: 1042 KPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHV---ND 1098
+ +LE++ + L+ L+ E+++ T RK ER+VKEL+ Q E++R++V D
Sbjct: 1808 GGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQD 1867
Query: 1099 QKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSL 1152
D+L ++VK+ KRQ +EA+E+ +KAQ E+EE E + ++++ L
Sbjct: 1868 LVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKL 1921
Score = 149 bits (377), Expect = 1e-35
Identities = 232/917 (25%), Positives = 395/917 (43%), Gaps = 139/917 (15%)
Query: 343 KMQPLVMVSSGSTKAVAGQGELTRKVEELQRK-------LDEEVKKRQKLEPSQVGLERQ 395
K++ L SG + +A +LTR+ + LQ L E K L ++ LE+Q
Sbjct: 975 KVKNLTEELSGLDETIA---KLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQ 1031
Query: 396 ---LEEKTEECSRLQELLERRKGE-------AQQSNKELQNMKRLLDQGEDLRHGLETQV 445
LE E+ +L+ LER K + AQ+S +L+N K+ LD+ + + +
Sbjct: 1032 VEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKK---DFEY 1088
Query: 446 MELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQ----RVEEQLRLRERELTALK 501
+LQ+K++ Q + +K+L E LEE +E ++ + E+Q REL L
Sbjct: 1089 CQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELS 1148
Query: 502 GALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQREL 561
L+E ++E + ++ + + +LRR +++AT H + A +K A +
Sbjct: 1149 ERLEEAGGVTSTQIE-LNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHA------DSV 1201
Query: 562 EETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELG--EKI-EVLQRELEQAR 618
E E+ + Q + QK +++ K E+ L E + + EKI L+ +L +AR
Sbjct: 1202 AELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEAR 1261
Query: 619 ASAGDT-RQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGR 677
+ R + L + R Q E EL + + +E R KQ + E + R
Sbjct: 1262 GKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRS--KQAFTQQTE-ELKR 1318
Query: 678 ELEEQNLQ---LQKTLQQLRQDC---------EEASKAKM---VAEAEATVLGQRRAAVE 722
+LEE+N L LQ R DC E+ KA++ +++A + V Q R E
Sbjct: 1319 QLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEV-AQWRTKYE 1377
Query: 723 TTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALN 782
T + EE +E +++ L Q+L+++ V+ A A L QRL+ E E L
Sbjct: 1378 TDAIQRTEELEEAKKK---LAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEV----EDLM 1430
Query: 783 ASQEEEGSLAAAK------------------RALEARLEEAQRGLARLGQEQQTLNRALE 824
E SLAAA +A LE + + L E L A E
Sbjct: 1431 VDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYE 1490
Query: 825 EEGKQREVLRRGK-------AELEEQKRLLDRTVDRLNK-----ELEKIG-----EDSKQ 867
E Q E ++R A+L EQ +T+ L K ELEK E+++
Sbjct: 1491 EALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEA 1550
Query: 868 ALQ-------QLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLS-------RLQD 913
AL+ ++Q +L K + R++A+ + + ++T + R ++
Sbjct: 1551 ALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRN 1610
Query: 914 EIQRLRQAL---------QASQAERDTARLDKEL--LAQRLQGLEQEAENKKRSQDDRAR 962
E RL++ + Q S A R A K L + +L+ + ++ R Q+D
Sbjct: 1611 EAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKE 1670
Query: 963 QLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKIS 1022
QL +E + + L+ E++E + T+E + R R +Q EL+ Q L S
Sbjct: 1671 QLAIVERRANLLQAEVEELRATLE----QTERARKLAEQ---ELLDSNERVQLLHTQNTS 1723
Query: 1023 LERQNKDLKT---RLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLE 1079
L K L+T +L S A ++ +++ + + AEE +K Q T+ LE
Sbjct: 1724 LIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKE--QDTSAHLE 1781
Query: 1080 RKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQH 1139
R K L ++D QH D+ +QL+L K K+Q+ + E I L+ + Q++ E
Sbjct: 1782 RMKKNLEQTVKD-LQHRLDEAEQLAL--KGGKKQIQKLETRIRELEFELEGEQKKNTESV 1838
Query: 1140 EVNEQLQARIKSLEKDS 1156
+ + + R+K L S
Sbjct: 1839 KGLRKYERRVKELTYQS 1855
Score = 146 bits (368), Expect = 1e-34
Identities = 198/940 (21%), Positives = 380/940 (40%), Gaps = 139/940 (14%)
Query: 355 TKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRL-------- 406
TK + E RK EL+ KL V+++ L+ L + E C +L
Sbjct: 860 TKDELAKSEAKRK--ELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLE 917
Query: 407 ---QELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKE 463
+E+ ER + E ++ N EL KR L ED L+ + +L+ L V+ + A E
Sbjct: 918 AKIKEVTERAEDE-EEINAELTAKKRKL---EDECSELKKDIDDLELTLAKVEKEKHATE 973
Query: 464 VLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQ 523
+K+L E L+E + R E+ L+E AL EE + + + + +
Sbjct: 974 NKVKNLTEELSGLDETIAKLTR--EKKALQEAHQQALDDLQAEE--DKVNSLNKTKSKLE 1029
Query: 524 RDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKED-- 581
+ E L S++ + LE ++K+ ++ Q + + + +K +
Sbjct: 1030 QQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYC 1089
Query: 582 -LRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDT-RQVEVLKKELLRTQE 639
L++ ++ L ++ ++ +EL +IE L+ E+E RA+ T +Q +EL E
Sbjct: 1090 QLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSE 1149
Query: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLR----- 694
L+E +Q + R+ E K LR R+LEE LQ + + LR
Sbjct: 1150 RLEEAGGVTSTQIELNKKREAEFLK----LR------RDLEEATLQHEAMVAALRKKHAD 1199
Query: 695 ------QDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKE 748
+ + + K E E + + +++ + + LE QL E
Sbjct: 1200 SVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSE 1259
Query: 749 TRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRG 808
RG + + + L + RL+ E +L L + L+ +K+A + EE +R
Sbjct: 1260 ARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQ 1319
Query: 809 LARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQA 868
L + + L AL+ ++LR E +E K L R + + N E+ + +
Sbjct: 1320 LEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETD 1379
Query: 869 LQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRL-----RQALQ 923
Q +LE+ K+K + + D++ Q + ++ RLQ E++ L R
Sbjct: 1380 AIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSL 1439
Query: 924 ASQAERDTARLDKELLAQRLQGLEQEAE-----NKKRSQDDRARQLK-GLEEKVSRLETE 977
A+ ++ DK L + + E +AE + RS +LK EE + +LET
Sbjct: 1440 AAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETV 1499
Query: 978 LDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASS 1037
E KN + + D +Q+ + + + +R+ +E +K ++ ++ + L
Sbjct: 1500 KRENKNLEQEIADLT----EQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHE 1555
Query: 1038 EG-FQKPSASLSQLESQ----------------------NQLLQERLQAEEREKTVLQST 1074
E + L+Q++S+ + +Q L AE R +
Sbjct: 1556 EAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRL 1615
Query: 1075 NRKLERKVKELSI---------------------QIEDERQHVNDQ-------KDQLSL- 1105
+K+E + E+ I Q++D + H++D K+QL++
Sbjct: 1616 KKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIV 1675
Query: 1106 --RVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNE-------------------- 1143
R L+ +V+E +E+ + RK A++E+ + +E +
Sbjct: 1676 ERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDL 1735
Query: 1144 -QLQARIKSLEKD---SWRKASRSAAESALKNEGLSSDEE 1179
QLQ+ ++ +D + KA ++ ++A+ E L +++
Sbjct: 1736 MQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQD 1775
Score = 117 bits (294), Expect = 5e-26
Identities = 134/596 (22%), Positives = 267/596 (44%), Gaps = 44/596 (7%)
Query: 620 SAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGREL 679
SA +++ +K+E +T++EL + +A+R +ELE++L L E + +L
Sbjct: 843 SAETEKEMATMKEEFQKTKDELAKSEAKR-----------KELEEKLVTLVQEKN---DL 888
Query: 680 EEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRI 739
+ Q + L + C++ KAK EA+ + +R + +E N E +
Sbjct: 889 QLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTER-------AEDEEEINAELTAKK 941
Query: 740 LGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALE 799
LE + E + +D E A++ + E + + L E L+ E L K+AL+
Sbjct: 942 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQ 1001
Query: 800 ARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRL---LDRTVDRLNK 856
E Q+ L L E+ +N + + K + + ++ LE++K+L L+R +L
Sbjct: 1002 ---EAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEG 1058
Query: 857 ELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQ 916
+L K+ ++S L+ + QL++ +K E Q + +D + + + LQ I+
Sbjct: 1059 DL-KLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIE 1117
Query: 917 RLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLET 976
L + ++A +A R + A+ L+ L + E + K E + +L
Sbjct: 1118 ELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRR 1177
Query: 977 ELDEEKNTVELLTDRVNRGR-DQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLA 1035
+L+E E + + + D V +L ++ + +Q LE +K + + DL +
Sbjct: 1178 DLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLS---S 1234
Query: 1036 SSEGFQKPSASLSQL--ESQNQLLQERLQAEEREKTVLQSTNRK--LERKVKELSIQIED 1091
S E K A+L ++ ++QL + R + EE ++++ + T +K L+ + ELS Q+E+
Sbjct: 1235 SMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEE 1294
Query: 1092 ERQHVND---QKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQAR 1148
+ V+ K + + + LKRQ++E + L + ++ + + E E+ Q
Sbjct: 1295 KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEG 1354
Query: 1149 IKSLEKDSWRKASRSAAESALKNE--GLSSDEEFDSVYDPSSIASLLTESNLQTSS 1202
L++ + KA+ A+ K E + EE + +A L +S Q +
Sbjct: 1355 KAELQR-ALSKANSEVAQWRTKYETDAIQRTEELEEA--KKKLAQRLQDSEEQVEA 1407
Score = 116 bits (290), Expect = 1e-25
Identities = 139/652 (21%), Positives = 293/652 (44%), Gaps = 72/652 (11%)
Query: 579 KEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQ 638
KE+ + TK EL + +++E+EE+L ++ Q +A + + E +L++
Sbjct: 854 KEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKA- 912
Query: 639 EELKELQAERQSQEVAGRHRD-RELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDC 697
+ Q E + +EV R D E+ +L + R+LE++ +L+K + L
Sbjct: 913 ----KFQLEAKIKEVTERAEDEEEINAELTA------KKRKLEDECSELKKDIDDLELTL 962
Query: 698 EEASKAKMVAEAEATVLGQRRAAVETTL----RETQEENDEFRRRILGLEQQLKETRGLV 753
+ K K E + L + + ++ T+ RE + + ++ + L+ + + L
Sbjct: 963 AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLN 1022
Query: 754 DGGEAVEARLRDKLQRLEAE----------KQQLEEALNASQEEEGSLAAAKRALEARLE 803
+E ++ D LE E K++LE L +QE L K+ L+ RL+
Sbjct: 1023 KTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLK 1082
Query: 804 EAQRGLARLG---QEQQT-----------LNRALEEEGKQREVLRRGKAELEEQKRLLDR 849
+ +L +++QT L +EE ++ E R +A+ E+Q+ R
Sbjct: 1083 KKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYAR 1142
Query: 850 TVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDW-ASEAEKTSGGL 908
++ L++ LE+ G + + +L + E K RR++ +A Q + A+ +K + +
Sbjct: 1143 ELEELSERLEEAGGVTSTQI-ELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSV 1201
Query: 909 SRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKK---RSQDDRARQLK 965
+ L ++I L++ Q + E+ +L+ + L+ ++ + + N + R+ +D+ + +
Sbjct: 1202 AELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEAR 1261
Query: 966 GLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSA-RQDLECDKISLE 1024
G E++ R +EL +K+ ++ ++R ++ + + ++L + + A Q E K LE
Sbjct: 1262 GKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLE 1321
Query: 1025 RQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKE 1084
+NK K LA +L LL+E+ + E+ K LQ K +V +
Sbjct: 1322 EENK-AKNALAH---------ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQ 1371
Query: 1085 LSIQIEDE----RQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHE 1140
+ E + + + + K +L+ R++ + QV+ + L+ +++ Q EVE+
Sbjct: 1372 WRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMV 1431
Query: 1141 VNEQLQARIKSLEKD---------SWR---KASRSAAESALKNEGLSSDEEF 1180
E+ + +L+K W+ + S++ E++LK S E F
Sbjct: 1432 DVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELF 1483
Score = 100 bits (249), Expect = 8e-21
Identities = 106/476 (22%), Positives = 217/476 (45%), Gaps = 49/476 (10%)
Query: 684 LQLQKTLQQLRQDCEEASKAK-MVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGL 742
L+ +T +++ EE K K +A++EA +R+ E + QE+ND L L
Sbjct: 841 LKSAETEKEMATMKEEFQKTKDELAKSEA----KRKELEEKLVTLVQEKND------LQL 890
Query: 743 EQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARL 802
+ Q E+ L+D E + ++ K Q LEA+ +++ E +E L A KR LE
Sbjct: 891 QVQA-ESENLLDAEERCDQLIKAKFQ-LEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 948
Query: 803 EEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIG 862
E ++ + L L + K++ L E+ LD T+ +L +E + +
Sbjct: 949 SELKKDI-------DDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQ 1001
Query: 863 EDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQAL 922
E +QAL LQA+ ED + + ++Q +D S E+ +L+ +++R ++ L
Sbjct: 1002 EAHQQALDDLQAE-EDKVNSLNKTKSKLEQQVEDLESSLEQE----KKLRVDLERNKRKL 1056
Query: 923 QASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEK 982
+ D +L + + L EN K+ D+R LK + + +L++++++E+
Sbjct: 1057 EG----------DLKLAQESILDL----ENDKQQLDER---LKKKDFEYCQLQSKVEDEQ 1099
Query: 983 NTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQK 1042
++ + ++++L E+ ER+ R E + R+ ++L RL + G
Sbjct: 1100 TLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTS 1159
Query: 1043 PSASLSQLESQNQLLQERLQAEE---REKTVLQSTNRKLERKVKELSIQIED---ERQHV 1096
L++ + + + L+ R EE + + ++ + +K V EL QI++ +Q +
Sbjct: 1160 TQIELNK-KREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKL 1218
Query: 1097 NDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSL 1152
+K + L + L ++ + L+ + + + ++ E NE++Q + L
Sbjct: 1219 EKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSEL 1274
Score = 73.6 bits (179), Expect = 1e-12
Identities = 90/402 (22%), Positives = 178/402 (44%), Gaps = 61/402 (15%)
Query: 361 QGELTRKVEELQRKLDEEVKK--RQKLEPSQVG--LERQLEEKTEECSRLQELLERRKGE 416
+ ++ +EE + L+ E K R +LE +QV ++R++ EK EE +L+ +R E
Sbjct: 1538 KADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTV-E 1596
Query: 417 AQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHV--QGPEPAKEV--LLKDLLET 472
QS + + R ++ L+ +E + E++ +L H Q E K + + L +T
Sbjct: 1597 TMQSALDAEVRSR--NEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDT 1654
Query: 473 RELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQ------------------- 513
+ L++ L G++ ++EQL + ER L+ ++E A+ +Q
Sbjct: 1655 QLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERV 1714
Query: 514 --------EVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETS 565
+ H +++ + D QL+ ++DA++D E + +K + EL++
Sbjct: 1715 QLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQ 1774
Query: 566 EETGHWQSMFQKNKEDL------RATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARA 619
+ + H + M +KN E R + E L L+ K+++++ L +I L+ ELE +
Sbjct: 1775 DTSAHLERM-KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK-LETRIRELEFELEGEQK 1832
Query: 620 SAGD---------------TRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEK 664
+ T Q E +K +LR Q+ + +LQ + +S + D +
Sbjct: 1833 KNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANA 1892
Query: 665 QLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMV 706
L R E EE+ + + +LR + + ++MV
Sbjct: 1893 HLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMV 1934
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 186 bits (472), Expect = 1e-46
Identities = 251/1053 (23%), Positives = 459/1053 (43%), Gaps = 125/1053 (11%)
Query: 192 QARGRTGRRTRMLPPEQ-RKRSKSLDSRLPRDTFEERERQSTNH--WTSSTKYDNHVGTS 248
Q G+R R EQ R+ ++ + ++ E+R+RQ + W ++
Sbjct: 128 QLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQER---E 184
Query: 249 KQPAQSQNLSPLSGFSRSRQTQDWVLQSFE--EPRRSAQDPTMLQFKSTPDLLRDQQEAA 306
++ A+ + L G + L+ E E RR ++ Q + D + ++E
Sbjct: 185 ERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEK 244
Query: 307 PPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVS-SGSTKAVAGQGELT 365
+ T+ E E E +R++ E+++ L + Q +
Sbjct: 245 EW----RKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL 300
Query: 366 RKVEELQRKLDEE------------VKKRQKLEPSQVGLERQLEEKTEECSRLQELLERR 413
R+ ++L+RK +EE ++ Q+ E + L R+ EE+ E+ R ++ ERR
Sbjct: 301 RREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERR 360
Query: 414 KGEAQQSNKELQNMKRL-----LDQGEDLRHGLE---TQVMELQNKLKHVQGPEPAKEVL 465
+ + ++ +E + ++L L + + LR + Q + + +L+ Q +++
Sbjct: 361 EQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 420
Query: 466 LKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRD 525
+ L RE EE E K E + + +RE + LK E + E E +QQ +RD
Sbjct: 421 REQQLR-REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD 479
Query: 526 TEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRAT 585
E+ RR ++ E R++ + L+RE EE E+ Q ++ ++ LR+
Sbjct: 480 QEEERRERWLKLEE----EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE 535
Query: 586 KQELLQLRMEKEEMEEEL---GEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELK 642
+ QLR E+EE E+L E+ + Q EQ + R+ ++LK+E R Q+ LK
Sbjct: 536 Q----QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLK 591
Query: 643 ELQAERQSQ-----EVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDC 697
Q ER Q EV ++ E++L E +R ++L + Q ++ QQLR++
Sbjct: 592 REQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQ 651
Query: 698 EEASKAKMVAEAEATVLGQR--------RAAVETTLRETQEENDEFRRRILGLEQQLKE- 748
+E + ++ E E L QR R E E ++ + + RI + QL+
Sbjct: 652 QERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESE 711
Query: 749 ---------TRGLVDGGEAVEARLRDKLQRLEAEKQ-QLEEALNASQEEEGSLAAAKRAL 798
+R G+ +K +R E+E Q Q EE + Q+EE
Sbjct: 712 ADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQW 771
Query: 799 EARLEEAQRGLARLGQ----EQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRL 854
+A E+++RG RL +Q + EE +QRE + E +EQ+R R
Sbjct: 772 QAE-EKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR---RQRRER 827
Query: 855 NKELEKIGEDS----KQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSR 910
KEL+ + E+ ++ QQLQ + + +E R + QR+ + W +
Sbjct: 828 EKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQ---------- 877
Query: 911 LQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEK 970
L++E +R R L A A ++ R +++LL + + L++E K+R Q+ +E+
Sbjct: 878 LEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQE---------QER 928
Query: 971 VSRLETELDEEKNTVELLTDRVNRGRDQVD-QLRTELMQERSARQDLECDKISLERQNKD 1029
R E +L +E+ + L +R R R + + Q R + ++ Q L + RQ ++
Sbjct: 929 QYREEEQLQQEEEQL-LREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE 987
Query: 1030 LKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQI 1089
K R E + Q +E+L EEREK Q R+ RK EL
Sbjct: 988 KKYR----------------EEEELQQEEEQLLREEREKRRRQEWERQY-RKKDELQ--- 1027
Query: 1090 EDERQHVNDQKDQLSLRVKALK-RQVDEAEEEIERLDGLRKKAQR--EVEEQHEVNEQLQ 1146
++E Q + +++++ L+ + + R+ +E ++E E+L G ++ +R E+E Q+ E+LQ
Sbjct: 1028 QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQ 1087
Query: 1147 ARIKSLEKDSWRKASRSAAESALKNEGLSSDEE 1179
+ L ++ K R E + E EE
Sbjct: 1088 QEEEQLLREEPEKRRRQERERQCREEEELQQEE 1120
Score = 159 bits (402), Expect = 2e-38
Identities = 236/1059 (22%), Positives = 458/1059 (43%), Gaps = 157/1059 (14%)
Query: 175 LSSVDSLINKFDSQLGGQARGRTGRRTRMLPPEQRKRSKSLDSRLPRDTFEERERQSTNH 234
L L+ + + +L + R + R+ + + ++ + + +L R+ E+R RQ
Sbjct: 899 LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER 958
Query: 235 WTSSTKYDNHVGTSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKS 294
K K + + L R RQ ++ + EE ++ +
Sbjct: 959 QYRKDK--------KLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQ-------- 1002
Query: 295 TPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGS 354
LLR+++E + E E R+K L E+ Q ++
Sbjct: 1003 ---LLREERE------------------KRRRQEWERQYRKKDELQQEEEQ--LLREERE 1039
Query: 355 TKAVAGQGELTRKVEELQRKLDE------EVKKRQKLEPSQVGLERQLEEKTEECSRLQE 408
+ + + R+ EELQ++ ++ E ++RQ+LE Q E +L+++ E+ R +E
Sbjct: 1040 KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELE-RQYRKEEELQQEEEQLLR-EE 1097
Query: 409 LLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQV-MELQNKLKHVQGPEPAKEVLLK 467
+RR+ E ++ +E + +++ ++ + LR E + EL+ + + + + +E LL+
Sbjct: 1098 PEKRRRQERERQCREEEELQQ--EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155
Query: 468 DLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHV--------- 518
+ E R E LE + R EE+L+ E +L L+EE R QE E
Sbjct: 1156 EEPEKRRRQE--LERQYREEEELQQEEEQL------LREEQEKRRQERERQYREEEELQR 1207
Query: 519 --RQQYQRDTEQL-------RRSMQDATQDHAVL------EAERQKMSALVRGLQRELE- 562
R+Q RD +Q ++A +D+ V E RQ + +R Q + +
Sbjct: 1208 QKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDL 1267
Query: 563 ----------ETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEE---LGEKIEV 609
+ +E WQ + E+ + ++E + + + +EE L E+ E
Sbjct: 1268 QHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREE 1327
Query: 610 LQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVL 669
+R E R + + ++ +++ LR QE ++ + E + GR + LE++ +
Sbjct: 1328 KRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGR---KFLEEEQRLR 1384
Query: 670 RVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQ 729
R E +R EEQ L+ Q+ QQLRQD + + E E + Q R + RE +
Sbjct: 1385 RQERERKFLKEEQQLRCQEREQQLRQD-----RDRKFREEEQQLSRQER---DRKFREEE 1436
Query: 730 EE--NDEFRRRILGLEQQLKETRG--LVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQ 785
++ E R+ L EQQL++ R + + ++ R +L R E +++ LEE +
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR 1496
Query: 786 EEEG---------SLAAAKRALEARLE-EAQRGLARLGQEQQTLNRALEEEGKQREVLRR 835
+E S ++ LE + Q+ + QE+Q L R +E G+QR R
Sbjct: 1497 QERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRR--QERGQQRRQDRD 1554
Query: 836 GKAELEEQKRLLDRTVDRLNKELE----KIGEDSKQALQQLQAQLEDYKEKARREVADAQ 891
K EEQ R +R +L+++ ++ E + +Q + +ED ++ R+E
Sbjct: 1555 RKFREEEQLRQ-EREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQL 1613
Query: 892 RQAKDWASEA------EKTSGGLSRLQDEIQRLRQALQASQAERDTA-RLDKELLAQRLQ 944
RQ +D E+ L R + + + L + Q + ER+ R D++ + +
Sbjct: 1614 RQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEE 1673
Query: 945 GLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRT 1004
L QE E ++ + +R R+ + E+++ R E E + +L + R + +QLR
Sbjct: 1674 QLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQ 1733
Query: 1005 ELMQERSARQDL------------ECDKISLERQNKDLKTRLASSEGFQKPSASLSQLES 1052
E QE+ RQ+ E ++ L RQ +D K R ++ L ES
Sbjct: 1734 ETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQES 1793
Query: 1053 QNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKD-------QLSL 1105
+ +E +ERE+ L+ R + + +E +Q+E++ Q + ++D Q +
Sbjct: 1794 DRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFAT 1853
Query: 1106 RVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQ 1144
+ K+ + + + +EE ++ R++ +R++ E+H +Q
Sbjct: 1854 QEKSRREEQELWQEEEQK---RRQERERKLREEHIRRQQ 1889
Score = 149 bits (375), Expect = 2e-35
Identities = 233/1047 (22%), Positives = 449/1047 (42%), Gaps = 112/1047 (10%)
Query: 187 SQLGGQARGRTGRRTRMLPPEQRKRSKSL-----DSRLPRDTFEERERQS-TNHWTSSTK 240
S++ + R + G+R R E+R+R +S + R R EE +R+ T W + K
Sbjct: 717 SKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEK 776
Query: 241 YDNHVG--TSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTM---LQFKST 295
+ +++ P + Q L R ++ Q ++ + E+ +R Q LQF
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 296 PDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGST 355
+ L+ ++ A ++ G L+E + +R+ +++ +
Sbjct: 837 EEQLQRRERA------QQLQEEEDG-LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL 889
Query: 356 KAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELL--ERR 413
A E RK ++L ++ +EE+++ ++ + + ERQ E+ + ++LL ER
Sbjct: 890 YAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREERE 949
Query: 414 KGEAQQSNKELQNMKRLLDQGEDL--RHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLE 471
K Q+ ++ + K+L + E L + + E + K + + + +E LL++ E
Sbjct: 950 KRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE 1009
Query: 472 TRELLEEVLEGK-----QRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDT 526
R E + + Q+ EEQL ERE L+ +E ++E++ +Q +
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQE--RERQYREEEELQQEEEQLLGEE 1067
Query: 527 EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQ-KNKEDLRAT 585
+ RR + LE + +K L + ++ L E E+ + Q + +E+L+
Sbjct: 1068 RETRRRQE--------LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQE 1119
Query: 586 KQELLQLRMEK---EEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELK 642
+++LL+ EK +E+E + E+ EV Q E + R R+ E+ ++ R +EEL+
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQ--YREEEELQ 1177
Query: 643 --ELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEA 700
E Q R+ QE + R+R+ ++ + R + + E+Q L+ + +++
Sbjct: 1178 QEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRD 1237
Query: 701 SKA-------KMVAEAEATVLGQRRAA--VETTLRETQE-ENDEFRRRILGLEQQLKETR 750
+K + + E + L R++ ++ L E QE + ++ RRR ++ E
Sbjct: 1238 NKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEE 1297
Query: 751 GLVDGGEAVEARLRDK--------LQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARL 802
L + E EA+ RD+ L+ EK++ +E +EEE L + R
Sbjct: 1298 QL-EREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356
Query: 803 EEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIG 862
E ++ + Q+ + LEEE + R R K EEQ+ +L ++ ++
Sbjct: 1357 ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR-- 1414
Query: 863 EDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQAL 922
++ QQL Q D K + + Q + + + E ++ R E ++L Q
Sbjct: 1415 -KFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQER 1473
Query: 923 QASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEK 982
+ Q R D++ L + Q QE + K R Q+ R+++ E K E +L ++
Sbjct: 1474 EEQQLHRQ--ERDRKFLEEEQQLRRQERDRKFREQELRSQE---PERKFLEEEQQLHRQQ 1528
Query: 983 NTVELLTD-----RVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASS 1037
+ L + R RG+ + + +E RQ+ E ++S RQ +D K RL
Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS--RQERDRKFRLEEQ 1586
Query: 1038 E--------GFQKPSASLSQLESQNQLLQER----------LQAEEREKTVLQSTNRK-L 1078
+ F + L + E Q QL QER LQ E ++ Q +RK L
Sbjct: 1587 KVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFL 1646
Query: 1079 ERKVKELSIQIEDERQHVNDQK-----------DQLSLRVKALKRQVDEAEEEIERLDGL 1127
E + + + E + +H D+K ++ LR + R+ E E+++ R +
Sbjct: 1647 EEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE 1706
Query: 1128 RKKAQREVEEQHEVNEQLQARIKSLEK 1154
RK Q EEQ ++L+ + + E+
Sbjct: 1707 RKFLQ---EEQQLRRQELERKFREEEQ 1730
Score = 140 bits (354), Expect = 6e-33
Identities = 230/988 (23%), Positives = 434/988 (43%), Gaps = 105/988 (10%)
Query: 179 DSLINKFDSQLGGQARGRTGRRTRMLPPEQRKRSKSLDSRLPRDTFEERERQSTNHWTSS 238
D + + + QL G+ + R+ R + + + + +L R EERE++ W
Sbjct: 963 DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLR---EEREKRRRQEWERQ 1019
Query: 239 TKYDNHVGTSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDL 298
+ K Q + L R+ Q+ Q EE ++ +L + +
Sbjct: 1020 YR-------KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER--ET 1070
Query: 299 LRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAV 358
R Q+ + ++ +LRE + R + E++Q +
Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREK 1130
Query: 359 AGQGELTRKV---EELQRK----LDEEVKKRQKLEPSQVGLERQLEEKTE----ECSRLQ 407
+ EL R+ EE+Q++ L EE +KR++ E LERQ E+ E E L+
Sbjct: 1131 RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQE-----LERQYREEEELQQEEEQLLR 1185
Query: 408 ELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLK 467
E E+R+ E ++ +E + ++R Q R+ E Q +L+ + EP KE ++
Sbjct: 1186 EEQEKRRQERERQYREEEELQR---QKRKQRYRDEDQRSDLKWQW------EPEKENAVR 1236
Query: 468 DLLETRELLEEVLEGKQ-RVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDT 526
D ++ + E +Q R E +LR+R+ L E RD+E E R Q QRD
Sbjct: 1237 D----NKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQ-QRDR 1291
Query: 527 -----EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKED 581
EQL R Q + E +++ R +R +ET + + + Q+ +E
Sbjct: 1292 HFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE- 1350
Query: 582 LRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKEL-LRTQEE 640
Q L + +++ EEEL + E ++ LE+ + R+ + LK+E LR QE
Sbjct: 1351 -----QPLRRQERDRKFREEELRHQ-EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER 1404
Query: 641 LKELQAER------QSQEVAGRHRDREL-EKQLAVLRVEADRGRELEEQNLQLQKTL--- 690
++L+ +R + Q+++ + RDR+ E++ V R E +R EEQ L+ ++
Sbjct: 1405 EQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFR 1464
Query: 691 --QQLRQDCEEASKAKMVAEAEATVLGQ--RRAAVETTLRETQEENDEFRRRILGLEQQL 746
+QL Q+ EE + + + Q RR + RE + + E R+ L EQQL
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524
Query: 747 ---KETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLE 803
+ R + + + + R + +R + +++ EE + EE L+ +R + RLE
Sbjct: 1525 HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLE 1584
Query: 804 EA----QRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELE 859
E Q + +++Q L R +EG+Q+ R + E+++ L +R +L+++
Sbjct: 1585 EQKVRRQEQERKFMEDEQQLRR---QEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641
Query: 860 K---IGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQ 916
+ E+ + Q+ + QL +++ RE ++ ++ ++ + +++
Sbjct: 1642 DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLR 1701
Query: 917 RLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLET 976
R + + Q E+ R + E + + L QE E ++ + +R R++ LEE+ R E
Sbjct: 1702 RQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKI--LEEEQLRPER 1759
Query: 977 ELDEEKNTVELLTDRVNRGRDQVDQLRTE--LMQERSARQDLECDKISLERQNKDLKTRL 1034
E E+ DR R +Q+ Q R E L + S R+ E +++ ER+ + L+ +
Sbjct: 1760 E---EQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQ- 1815
Query: 1035 ASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQ----STNRKLERKVKELSIQIE 1090
+G + QLE Q Q L+ +ER++ +T K R+ +EL + E
Sbjct: 1816 -QRDGKYRWEEEQLQLEEQEQRLR-----QERDRQYRAEEQFATQEKSRREEQELWQEEE 1869
Query: 1091 DERQHVNDQKDQLSLRVKALKRQVDEAE 1118
+R+ ++K LR + ++RQ E +
Sbjct: 1870 QKRRQERERK----LREEHIRRQQKEEQ 1893
Score = 138 bits (347), Expect = 4e-32
Identities = 172/687 (25%), Positives = 309/687 (44%), Gaps = 86/687 (12%)
Query: 504 LKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEE 563
L EE +R E + Q +++ +Q R +D + + RQK +REL E
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQ----ERELAE 150
Query: 564 TSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGD 623
E++ + + Q++++ +EL + R E +E EE E+ E LQ D
Sbjct: 151 GEEQSEKQERLEQRDRQ---RRDEELWRQRQEWQEREERRAEE-EQLQSCKGHETEEFPD 206
Query: 624 TRQVEVLKKELL---RTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELE 680
Q+ ++ELL R E K+ Q + V ++E K+ VLR E ++ L+
Sbjct: 207 EEQLR--RRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK---LQ 261
Query: 681 EQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRIL 740
E+ Q Q+ LQ+ + + + ++ E + Q+R E LR QEE RR
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEE----RR-- 315
Query: 741 GLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEA 800
+Q +E R + E E R +L+R + E++ E+ L QEEE
Sbjct: 316 ---EQQEERREQQERREQQEERREQQLRREQEERR--EQQLRREQEEE------------ 358
Query: 801 RLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEK 860
+ +Q L R EEE +++++ R + E+Q R +L +E +
Sbjct: 359 -------------RREQQLRREQEEERREQQLRREQQLRREQQLR----REQQLRREQQL 401
Query: 861 IGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQ 920
E + QQL+ + + +E+ R + +R + E + RL+ E + R
Sbjct: 402 RREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE-----QRLKREQEERRD 456
Query: 921 ALQASQAERDTARLDKELLAQRLQGLEQEAENKKR-----------SQDDRARQLKGLEE 969
L+ E +T R ++E Q+L+ +QE E ++R Q+ R +QL+ +E
Sbjct: 457 WLKR---EEETERHEQERRKQQLKR-DQEEERRERWLKLEEEERREQQERREQQLRREQE 512
Query: 970 --KVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQN 1027
+ RL+ + +EE+ L +++ R R+Q ++ L +E R + E + L+R+
Sbjct: 513 ERREQRLKRQEEEERLQQRLRSEQQLR-REQEERREQLLKREEEKRLEQERREQRLKREQ 571
Query: 1028 KDLKTRLASSEGFQKPS-ASLSQLESQNQLLQ----ERLQAEEREKTVLQSTNRKLERKV 1082
++ + +L E ++ Q E Q L+ ERL+ EER + L+ + ER+
Sbjct: 572 EERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQ 631
Query: 1083 KELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVN 1142
+ L + ++ER+ +++Q R + LKR+ +E E +RL ++ +RE E E
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE-QRLKREHEEERREQELAEEEQ 690
Query: 1143 EQLQARIKS-LEKDSWRKASRSAAESA 1168
EQ + RIKS + K W+ S + A +
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQS 717
Score = 118 bits (296), Expect = 3e-26
Identities = 162/639 (25%), Positives = 281/639 (43%), Gaps = 59/639 (9%)
Query: 366 RKVEELQRKLDEEVKKRQ----KLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSN 421
R+ E+L ++ +E+ +RQ K ++ + Q + EE RL+ RK ++
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Query: 422 KELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPA--KEVLLKDLLETRELLEEV 479
Q ++ L Q D + E Q + Q + + + E ++ + LE + L +
Sbjct: 1399 LRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQE 1458
Query: 480 LEGKQRVEEQLRLRERELTAL------KGALKEEVASRDQEVEH-VRQQYQRDTEQLRRS 532
K R EEQL L+ERE L + L+EE R QE + R+Q R E R+
Sbjct: 1459 RHRKFREEEQL-LQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKF 1517
Query: 533 MQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQL 592
+++ Q H +RQ+ + LQ E + +E G Q+ ++D +E QL
Sbjct: 1518 LEEEQQLH---RQQRQR-----KFLQEEQQLRRQERG------QQRRQDRDRKFREEEQL 1563
Query: 593 RMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQE 652
R E+EE + E+ + E ++ R + + +E ++ LR QE ++L+ ER +
Sbjct: 1564 RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFME--DEQQLRRQEGQQQLRQERDRKF 1621
Query: 653 VAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEA--SKAKMVAEAE 710
+E E+Q + R E DR EE L+ Q+ QQLR D + + +++ E E
Sbjct: 1622 REDEQLLQEREEQ-QLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE 1680
Query: 711 ATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKET---RGLVDGGEAVEARLRDKL 767
L ++ + E Q E R+ L EQQL+ R + + + +++L
Sbjct: 1681 EQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL 1740
Query: 768 QRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEG 827
+R E ++ LEE + EE L +R + R EE R + +EQQ ++ + +
Sbjct: 1741 RRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLR---QEREEQQLRSQESDRKF 1797
Query: 828 KQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREV 887
++ E LR+ E EEQ +L D K ++ Q QLE+ +++ R+E
Sbjct: 1798 REEEQLRQ---EREEQ-------------QLRPQQRDGKYRWEEEQLQLEEQEQRLRQE- 1840
Query: 888 ADAQRQAKDWASEAEKTSGGLSRL-QDEIQRLRQALQASQAERDTARLDKELLAQRLQG- 945
D Q +A++ + EK+ L Q+E Q+ RQ + E R KE R G
Sbjct: 1841 RDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGE 1900
Query: 946 -LEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKN 983
QE + R + Q + + S L + E+++
Sbjct: 1901 IKSQEGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQRS 1939
Score = 66.2 bits (160), Expect = 2e-10
Identities = 99/443 (22%), Positives = 184/443 (41%), Gaps = 40/443 (9%)
Query: 186 DSQLGGQARGRT----GRRTRMLPPEQRKRSKSLDSRLPRDTFEERERQSTNHWTSSTKY 241
+ QL Q R R ++ R +++ R + L S+ P F E E+Q
Sbjct: 1475 EQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFL 1534
Query: 242 DNHVGTSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRD 301
+Q Q R + ++ + Q EE + S Q+ +F+ +R
Sbjct: 1535 QEEQQLRRQERGQQRRQDRD---RKFREEEQLRQEREEQQLSRQERDR-KFRLEEQKVR- 1589
Query: 302 QQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQ 361
+QE D + ++ E + R L+ E+ + + K + +
Sbjct: 1590 RQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEE 1649
Query: 362 GELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKT------EECSRLQELLERRKG 415
+L R+ E Q + D + K R++ + Q G E+QL + EE +L+ RK
Sbjct: 1650 PQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKF 1709
Query: 416 EAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETREL 475
++ Q ++R + E LR E + + Q + + + +E L+ E ++L
Sbjct: 1710 LQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKI-----LEEEQLRPEREEQQL 1764
Query: 476 LEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQD 535
+ + K R EEQLR +ERE L+ +E + +E E +RQ+ R+ +QLR +D
Sbjct: 1765 RRQERDRKFREEEQLR-QEREEQQLRS---QESDRKFREEEQLRQE--REEQQLRPQQRD 1818
Query: 536 AT----QDHAVLEAERQKMSALVRGLQRELEET--------SEETGHWQSMFQKNKEDL- 582
++ LE + Q++ R Q EE EE WQ QK +++
Sbjct: 1819 GKYRWEEEQLQLEEQEQRLRQ-ERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERE 1877
Query: 583 RATKQELLQLRMEKEEMEEELGE 605
R ++E ++ + ++E+ ++GE
Sbjct: 1878 RKLREEHIRRQQKEEQRHRQVGE 1900
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 185 bits (469), Expect = 3e-46
Identities = 229/910 (25%), Positives = 405/910 (44%), Gaps = 137/910 (15%)
Query: 364 LTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLE-------EKTEECSRLQELLERRKGE 416
L ++VE+L+ L++E K R E ++ LE L+ + ++ +L+E L+++ E
Sbjct: 1076 LEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSE 1135
Query: 417 AQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGP----EPAKEVLLKDLLET 472
Q + +++ + L Q + L+ + EL+ +L+ + E + ++L E
Sbjct: 1136 LSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEEL 1195
Query: 473 RELLEEVLEGKQRVEEQLRLRERELTALKGALKE---------------------EVASR 511
E LEE E R RE EL L+ L+E E+ +
Sbjct: 1196 SERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQ 1255
Query: 512 DQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETS---EET 568
++ VRQ+ +++ +LR + D + L + L R + +L E EE
Sbjct: 1256 VDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEEL 1315
Query: 569 GHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELG-------EKIEVLQRELEQ-ARAS 620
+ + L+ EL +L EKE + +L + +E L+R+LE+ ++A
Sbjct: 1316 QRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAK 1375
Query: 621 AGDTRQVEVLKKE--LLRTQ-EELKELQAE---------------RQSQEVAGRHRDREL 662
+ V+ L+ + LLR Q EE E QAE R E R EL
Sbjct: 1376 SALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEEL 1435
Query: 663 E---KQLAVLRVEADRGRELEEQNLQ-LQKTLQQLRQDCEEASKAKMVAEAEATVLGQRR 718
E K+LA+ EA+ G E L+K +L+ + E+ + A + A L +++
Sbjct: 1436 EEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQ 1495
Query: 719 AAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDG--------GEAVEA--RLRDKLQ 768
+E L E + + +E +R LE +E+RGL EA+EA L+ + +
Sbjct: 1496 RHLERALEERRRQEEEMQRE---LEAAQRESRGLGTELFRLRHGHEEALEALETLKRENK 1552
Query: 769 RLEAEKQQLEEALNASQEEEGSLAAAKRALE-------ARLEEAQRGLA----------- 810
L+ E L + ++ S + L K+ALE A LEEA+ L
Sbjct: 1553 NLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQL 1612
Query: 811 RLGQEQQTLNRALEEEGKQREVLRRG--------KAELEEQKRLLDRTVDRLNKELE--- 859
L Q + ++R L E+ ++ LRR +A L+ + R + + RL K++E
Sbjct: 1613 ELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEAL-RLKKKMEGDL 1671
Query: 860 -----KIGEDSKQALQQ------LQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGL 908
++G ++QA + +QAQL++ E+A R+ + QR A + +A+
Sbjct: 1672 NDLELQLGHATRQATEAQAATRLMQAQLKE--EQAGRD--EEQRLAAELHEQAQALERRA 1727
Query: 909 SRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRA-RQLKGL 967
S L E++ LR AL+ Q ER ++ELL E N SQ+ Q K L
Sbjct: 1728 SLLAAELEELRAALE--QGERSRRLAEQELLEAT------ERLNLLHSQNTGLLNQKKKL 1779
Query: 968 EEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQN 1027
E +++L E++E ++ + + EL +E+ LE K +LE+
Sbjct: 1780 EADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTV 1839
Query: 1028 KDLKTRLASSE--GFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKEL 1085
++L+ RL +E + + +LE++ + L+ L AE+++ RK ER+VKEL
Sbjct: 1840 RELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKEL 1899
Query: 1086 SIQIEDERQH---VNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVN 1142
+ Q E++R++ + D D+L +VK+ KRQ +EAE++ +KAQ E+++ E
Sbjct: 1900 AYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERA 1959
Query: 1143 EQLQARIKSL 1152
+ + + L
Sbjct: 1960 DMAETQANKL 1969
Score = 160 bits (406), Expect = 5e-39
Identities = 206/899 (22%), Positives = 392/899 (43%), Gaps = 106/899 (11%)
Query: 363 ELTRKVEELQRKLDEEVKKRQKLE-------PSQVGLERQLEEKTEECSRLQELLERRKG 415
EL + +++L+ L + K++Q E L+ + T+E LQE ++ G
Sbjct: 998 ELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALG 1057
Query: 416 EAQQSNKELQNMK----RLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLE 471
+ Q + + RL Q EDL LE + KL+ E AK L DL
Sbjct: 1058 DLQAEEDRVSALTKAKLRLEQQVEDLECSLEQE-----KKLR--MDTERAKRKLEGDLKL 1110
Query: 472 TRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRR 531
T+E + + + KQ++EE+L+ ++ EL+ L +++E Q + +++ R E+L
Sbjct: 1111 TQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQAR-AEELEE 1169
Query: 532 SMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQ 591
++ A +E +R + + + L LEE + + +K + +L ++EL +
Sbjct: 1170 ELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEE 1229
Query: 592 -----------LRMEKEEMEEELGEKIEVLQRELEQARASAGDTR-QVEVLK---KELLR 636
LR ++ E ELGE+++ LQR ++ + R +V+ L + L R
Sbjct: 1230 AALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTR 1289
Query: 637 TQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADR--------GRELEEQNLQLQK 688
+ ++L + Q + + EL++QLA + R R LEE+ + +
Sbjct: 1290 AKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQ 1349
Query: 689 ----------TLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRR 738
+L++LR+ EE SKAK L + E E E +R
Sbjct: 1350 LSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRL 1409
Query: 739 ILGLEQQLKETRGLVDGGEAVEA--RLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKR 796
+ ++ + R + +A++ L + ++L Q+ EE + A+ + SL AK
Sbjct: 1410 LSKANAEVAQWRSKYEA-DAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKL 1468
Query: 797 ALEAR-------LEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDR 849
L+ LE A A L ++Q+ L RALEE +Q E ++R + + R L
Sbjct: 1469 RLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGT 1528
Query: 850 TVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLS 909
+ RL E++ +AL+ L+ + ++ +E+ ++ D + E EKT L
Sbjct: 1529 ELFRLRHG----HEEALEALETLKRENKNLQEEIS-DLTDQVSLSGKSIQELEKTKKALE 1583
Query: 910 RLQDEIQR-LRQALQASQAERD-TARLDKEL------LAQRLQGLEQEAENKKRSQDDRA 961
+ EIQ L +A A + E T R+ EL + ++L ++E N +R+
Sbjct: 1584 GEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAV 1643
Query: 962 RQLKG-------LEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQ----LRTELMQER 1010
L+ + RL+ +++ + N +EL R + ++ +L +E+
Sbjct: 1644 ESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQ 1703
Query: 1011 SARQDLECDKISLERQNKDLKTR--LASSEGFQKPSASLSQLESQNQLL-QERLQAEER- 1066
+ R + + L Q + L+ R L ++E ++ A+L Q E +L QE L+A ER
Sbjct: 1704 AGRDEEQRLAAELHEQAQALERRASLLAAE-LEELRAALEQGERSRRLAEQELLEATERL 1762
Query: 1067 -----EKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEI 1121
+ T L + +KLE + +LS ++E+ Q + +++ + +E ++E
Sbjct: 1763 NLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQ 1822
Query: 1122 E---RLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSD 1177
+ L+ ++K ++ V E LQAR++ E+ + R + + K L ++
Sbjct: 1823 DTSAHLERMKKTLEQTVRE-------LQARLEEAEQAALRGGKKQVQKLEAKVRELEAE 1874
Score = 157 bits (396), Expect = 7e-38
Identities = 196/846 (23%), Positives = 360/846 (42%), Gaps = 117/846 (13%)
Query: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 422
+L KV+EL +L++E +++ R+LE+ EC+ L++ ++ K ++ K
Sbjct: 963 QLEGKVKELSERLEDE----EEVNADLAARRRKLED---ECTELKKDIDDLKLTLAKAEK 1015
Query: 423 ELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEG 482
E Q + + + L+ V L + K +Q A + L DL + + + +
Sbjct: 1016 EKQATENKVKNLTEEMAALDESVARLTKEKKALQ---EAHQQALGDLQAEEDRVSALTKA 1072
Query: 483 KQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAV 542
K R+E+Q+ L+ +L++E R + E +++ + D + + S+ DA QD
Sbjct: 1073 KLRLEQQVE-------DLECSLEQEKKLR-MDTERAKRKLEGDLKLTQESVADAAQDKQQ 1124
Query: 543 LEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEE 602
LE + +K + EL + S LR ++LL +M+K+ +E
Sbjct: 1125 LEEKLKKKDS-------ELSQLS----------------LRVEDEQLLGAQMQKKI--KE 1159
Query: 603 LGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDREL 662
L + E L+ ELE RA+ +VE + E R EEL E E R R+
Sbjct: 1160 LQARAEELEEELEAERAARA---RVEKQRAEAARELEELSERLEEAGGASAGQREGCRKR 1216
Query: 663 EKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVE 722
E +L LR RELEE L+ + T+ LR+ E A LG++ +++
Sbjct: 1217 EAELGRLR------RELEEAALRHEATVAALRRKQAEG----------AAELGEQVDSLQ 1260
Query: 723 TTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALN 782
++ ++E E R + L ++ E + D+L + + ++L+ L
Sbjct: 1261 RVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLA 1320
Query: 783 ASQEEEGSLAAAKRALEARLEEAQ-------RGLARLGQEQQTLNRALEEEGKQR----- 830
+ + G L L LEE + RG A Q + L R LEEE K +
Sbjct: 1321 DASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAH 1380
Query: 831 ---------EVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKE 881
++LR E E + L R + + N E+ + + Q +LE+ K+
Sbjct: 1381 AVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKK 1440
Query: 882 KARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQ 941
K + +A+ + ++ RLQ E + + L+ +A A LDK
Sbjct: 1441 KLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDV--TLELERATSAAAALDK----- 1493
Query: 942 RLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETEL-------DEEKNTVELLTDRVNR 994
+ + LE+ E ++R +++ R+L+ + + L TEL +E +E L
Sbjct: 1494 KQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKN 1553
Query: 995 GRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEG---FQKPSASLSQLE 1051
++++ L ++ + Q+LE K +LE + +++ L +EG ++ QLE
Sbjct: 1554 LQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLE 1613
Query: 1052 -SQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVND----------QK 1100
SQ + +R AE+ E+ + R +R V+ L ++ E + N+
Sbjct: 1614 LSQVKAEVDRKLAEKDEECA--NLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDL 1671
Query: 1101 DQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKA 1160
+ L L++ RQ EA+ + K+ Q +E+ + +L + ++LE R+A
Sbjct: 1672 NDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALE----RRA 1727
Query: 1161 SRSAAE 1166
S AAE
Sbjct: 1728 SLLAAE 1733
Score = 129 bits (325), Expect = 1e-29
Identities = 182/792 (22%), Positives = 339/792 (42%), Gaps = 97/792 (12%)
Query: 281 RRSAQDPTMLQFKSTPDLLRDQQEAAPP--GSVDHMKATIYGILREGSSESETSVRRKVS 338
RR ++ + + L R Q E A VD ++ +R+ + ++ +R +V
Sbjct: 1224 RRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQR-----VRQKLEKEKSELRMEVD 1278
Query: 339 LVLEKMQPLVMVSSGSTKAVAGQ----GELTRKVEELQRKLDEEVKKRQKLEPSQVGLER 394
+ ++ L + + K E KVEELQR+L + +R +L+ L R
Sbjct: 1279 DLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSR 1338
Query: 395 QLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNK--- 451
LEEK EC L L R K A QS L+ ++R L++ + L V L++
Sbjct: 1339 LLEEK--EC--LISQLSRGKALAAQS---LEELRRQLEEESKAKSALAHAVQALRHDCDL 1391
Query: 452 LKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASR 511
L+ E + L+ LL EV + + + E R EL K L +
Sbjct: 1392 LREQHEEEAEAQAELQRLLSKANA--EVAQWRSKYEADAIQRTEELEEAKKKLALRLQEA 1449
Query: 512 DQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALV-----RGLQRELEETSE 566
++ VE + E+ + +Q ++D LE ER +A R L+R LEE
Sbjct: 1450 EEGVEAANAKCS-SLEKAKLRLQTESED-VTLELERATSAAAALDKKQRHLERALEERRR 1507
Query: 567 ETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGD-TR 625
+ Q + + + R EL +LR EE E L E L+RE + + D T
Sbjct: 1508 QEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEAL----ETLKRENKNLQEEISDLTD 1563
Query: 626 QVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELE-KQLAVLRVEADRGRELEEQNL 684
QV + K + ++ K L+ E+ + A + LE ++ LR++ EL +
Sbjct: 1564 QVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQL----ELSQVKA 1619
Query: 685 QLQKTLQQLRQDCEEASK--AKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGL 742
++ + L + ++C + + V +A++ + RA E + + E D + L
Sbjct: 1620 EVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGD-----LNDL 1674
Query: 743 EQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQL---EEALNASQEEEGSLAAAKRA-- 797
E QL +A EA+ +L + + +++Q EE A++ E + A +RA
Sbjct: 1675 ELQLGHATR-----QATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASL 1729
Query: 798 LEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKE 857
L A LEE + L + + ++ + L E ++ +L L QK+ L+ + +L+ E
Sbjct: 1730 LAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGE 1789
Query: 858 LEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQR 917
+E+ ++ ++A +EKA++ + DA A++ E + TS L R++ +++
Sbjct: 1790 VEEAAQERREA-----------EEKAKKAITDAAMMAEELKKEQD-TSAHLERMKKTLEQ 1837
Query: 918 LRQALQASQAERDTARL-----DKELLAQRLQGLEQE--AENKKRSQ------------- 957
+ LQA E + A L + L +++ LE E AE KK ++
Sbjct: 1838 TVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVK 1897
Query: 958 ------DDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTEL--MQE 1009
++ + L +++ V +L++++ K E + N + + + EL +E
Sbjct: 1898 ELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEE 1957
Query: 1010 RSARQDLECDKI 1021
R+ + + +K+
Sbjct: 1958 RADMAETQANKL 1969
Score = 111 bits (278), Expect = 4e-24
Identities = 153/617 (24%), Positives = 265/617 (42%), Gaps = 75/617 (12%)
Query: 620 SAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGREL 679
SA ++ L+ EL + L +A+RQ E +E L+ E D +
Sbjct: 891 SAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADA 950
Query: 680 EEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRI 739
EE+ L K+ QL +E S+ E L RR +E E +++ D+ + +
Sbjct: 951 EERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTL 1010
Query: 740 LGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALE 799
E++ + T V A L + + RL EK+ L+E A Q+ G L +A E
Sbjct: 1011 AKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQE---AHQQALGDL----QAEE 1063
Query: 800 ARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELE 859
R+ + RL Q+ + L +LE+E K R R K +LE +L +V ++ +
Sbjct: 1064 DRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQ 1123
Query: 860 KIGEDSKQ---ALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQ 916
++ E K+ L QL ++ED ++ AQ Q K + LQ +
Sbjct: 1124 QLEEKLKKKDSELSQLSLRVED------EQLLGAQMQKK------------IKELQARAE 1165
Query: 917 RLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGL---EEKVSR 973
L + L+A +A R AR++K+ A+ + LE+ +E + + A Q +G E ++ R
Sbjct: 1166 ELEEELEAERAAR--ARVEKQ-RAEAARELEELSERLEEAGGASAGQREGCRKREAELGR 1222
Query: 974 LETELDE----EKNTVELLTDRVNRGR----DQVDQLRTELMQERSARQDLECDKISLER 1025
L EL+E + TV L + G +QVD L + RQ LE +K L
Sbjct: 1223 LRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSL-------QRVRQKLEKEKSELRM 1275
Query: 1026 QNKDLKTRLASSEGFQKPSASLSQL--ESQNQLLQERLQAEEREKTVLQSTNR--KLERK 1081
+ DL A+ E + AS +L ++QL + +++ EE ++ + ++ + +L+ +
Sbjct: 1276 EVDDL---AANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTE 1332
Query: 1082 VKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQR------EV 1135
ELS +E++ ++ +L ++L+ + EEE + L Q +
Sbjct: 1333 SGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLL 1392
Query: 1136 EEQHEVNEQLQARIKSL------EKDSWRKASRSAA-------ESALKNEGLSSDEEFDS 1182
EQHE + QA ++ L E WR + A E A K L E +
Sbjct: 1393 REQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEG 1452
Query: 1183 VYDPSSIASLLTESNLQ 1199
V ++ S L ++ L+
Sbjct: 1453 VEAANAKCSSLEKAKLR 1469
Score = 75.1 bits (183), Expect = 4e-13
Identities = 110/448 (24%), Positives = 194/448 (43%), Gaps = 49/448 (10%)
Query: 328 ESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQ-GELTRKVEELQRKLDEEVKK--RQK 384
E + + +VSL + +Q L + KA+ G+ E+ +EE + L+ E K R +
Sbjct: 1556 EEISDLTDQVSLSGKSIQEL----EKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQ 1611
Query: 385 LEPSQVGLE--RQLEEKTEECSRL----QELLERRKGEAQQSNKELQNMKRLLDQGEDLR 438
LE SQV E R+L EK EEC+ L Q +E + + RL + E
Sbjct: 1612 LELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDL 1671
Query: 439 HGLETQVMELQNKLKHVQGPEPAKEVLLKDLL----ETRELLEEVLEGKQRVEEQLRLRE 494
+ LE Q+ + Q + LK+ E + L E+ E Q +E + L
Sbjct: 1672 NDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLA 1731
Query: 495 RELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALV 554
EL L+ AL++ SR Q+ TE+L T L +++K+ A +
Sbjct: 1732 AELEELRAALEQGERSR----RLAEQELLEATERLNLLHSQNTG----LLNQKKKLEADL 1783
Query: 555 RGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLR---MEKEEMEEELGEKIEVLQ 611
L E+EE ++E + +K D +EL + + E M++ L + + LQ
Sbjct: 1784 AQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQ 1843
Query: 612 RELEQARASAGDTRQVEVLKKELLRTQEELKELQAE------RQSQEVAGRHRDRELEKQ 665
LE+A +A + KK++ + + +++EL+AE + ++ + G + K+
Sbjct: 1844 ARLEEAEQAA-----LRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKE 1898
Query: 666 LAVLRVEADRGRELEEQNL--QLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVET 723
LA + E DR Q+L +LQ ++ ++ EEA + +A + R+A E
Sbjct: 1899 LA-YQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQ-----QANTNLAKYRKAQHE- 1951
Query: 724 TLRETQEENDEFRRRILGLEQQLKETRG 751
L + +E D + L + ++ G
Sbjct: 1952 -LDDAEERADMAETQANKLRARTRDALG 1978
Score = 63.2 bits (152), Expect = 1e-09
Identities = 80/357 (22%), Positives = 158/357 (44%), Gaps = 49/357 (13%)
Query: 324 EGSSESETSVRRKVSLVLEKMQ--------PLVMVSSGSTKAVAGQGELTRKVEELQRKL 375
+ S ++ET R + + +KM+ L + +T+A A + +++E Q
Sbjct: 1647 QASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGR 1706
Query: 376 DEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGE 435
DEE + L +L E+ + R LL EL+ ++ L+QGE
Sbjct: 1707 DEEQR-----------LAAELHEQAQALERRASLLA----------AELEELRAALEQGE 1745
Query: 436 DLRHGLETQVMELQNKLK--HVQ--GPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLR 491
R E +++E +L H Q G K+ L DL + +EE + ++ EE+ +
Sbjct: 1746 RSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAK 1805
Query: 492 LRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAER---Q 548
+ + LK+E +E +++ ++ +L+ +++A Q A L + Q
Sbjct: 1806 KAITDAAMMAEELKKE-QDTSAHLERMKKTLEQTVRELQARLEEAEQ--AALRGGKKQVQ 1862
Query: 549 KMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEK------EEMEEE 602
K+ A VR L+ EL+ +E+ H +++ K + R K+ Q ++ +++ ++
Sbjct: 1863 KLEAKVRELEAELD--AEQKKHAEALKGVRKHE-RRVKELAYQAEEDRKNLARMQDLVDK 1919
Query: 603 LGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRD 659
L K++ +R+ E+A A +T + K + E + AE Q+ ++ R RD
Sbjct: 1920 LQSKVKSYKRQFEEAEQQA-NTNLAKYRKAQHELDDAEERADMAETQANKLRARTRD 1975
Score = 38.9 bits (89), Expect = 0.030
Identities = 47/203 (23%), Positives = 86/203 (42%), Gaps = 45/203 (22%)
Query: 278 EEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKV 337
E+ +++ D M+ +L ++Q +A ++ MK T+ +RE + E + + +
Sbjct: 1802 EKAKKAITDAAMM----AEELKKEQDTSA---HLERMKKTLEQTVRELQARLEEAEQAAL 1854
Query: 338 SLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKR-------QKLEPSQV 390
G K V +L KV EL+ +LD E KK +K E
Sbjct: 1855 R--------------GGKKQVQ---KLEAKVRELEAELDAEQKKHAEALKGVRKHERRVK 1897
Query: 391 GLERQLEEKTEECSRLQELLERRKGEA-----------QQSNKELQNMKRL---LDQGED 436
L Q EE + +R+Q+L+++ + + QQ+N L ++ LD E+
Sbjct: 1898 ELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEE 1957
Query: 437 LRHGLETQVMELQNKLKHVQGPE 459
ETQ +L+ + + GP+
Sbjct: 1958 RADMAETQANKLRARTRDALGPK 1980
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 184 bits (466), Expect = 6e-46
Identities = 189/835 (22%), Positives = 379/835 (45%), Gaps = 61/835 (7%)
Query: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 422
EL ++EEL+ +++ E R K E + L R+LEE +E RL+E + + + K
Sbjct: 1114 ELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISE---RLEEAGGATSAQIEMNKK 1170
Query: 423 ---ELQNMKRLLDQGE--------DLRHGLETQVMELQNKLKHVQGP----EPAKEVLLK 467
E Q M+R L++ LR V EL ++ ++Q E K +
Sbjct: 1171 REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKM 1230
Query: 468 DLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASR-DQEVEHVRQQYQRDT 526
++ + +E V + K +E+ R E +L+ +K KEE R ++ R + Q ++
Sbjct: 1231 EIDDLASNMETVSKAKGNLEKMCRALEDQLSEIK--TKEEEQQRLINDLTAQRARLQTES 1288
Query: 527 EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATK 586
+ R + + + L +Q + + L+R+LEE + Q ++ D +
Sbjct: 1289 GEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLR 1348
Query: 587 QELLQLRMEKEEMEEELGE-KIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQ 645
++ + + K E++ + + EV Q + + T ++E KK+L + ++ +E
Sbjct: 1349 EQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEE-H 1407
Query: 646 AERQSQEVAGRHRDRE-LEKQLAVLRVEADRGRE----LEEQNLQLQKTLQQLRQDCEEA 700
E + + A + ++ L+ ++ L ++ +R L+++ K L + +Q CEE
Sbjct: 1408 VEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEET 1467
Query: 701 SKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKE-TRGLVDGGEAV 759
++ E+ L ++ E+ ++ + +R L+Q++ + T + +GG+ +
Sbjct: 1468 HAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRI 1527
Query: 760 EARLRDKLQRLEAEKQQLEEALNASQ----EEEGSLAAAKRALEARLEEAQRGLARLGQE 815
+ K Q +E EK +L+ AL ++ EEG + + L E R +A +E
Sbjct: 1528 HELEKIKKQ-VEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1586
Query: 816 QQTLNR----ALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQ 871
+ R +E + R + + K+ ++ ++ + +L + +AL+
Sbjct: 1587 IDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRN 1646
Query: 872 L---QAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAE 928
QA L+D + + DA R +D + + LQ EI+ LR L+ Q E
Sbjct: 1647 YRNTQAILKD----TQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLE--QTE 1700
Query: 929 RDTARLDKELL--AQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVE 986
R ++ELL ++R+Q L + + ++ K LE +S+++ E+++
Sbjct: 1701 RSRKIAEQELLDASERVQLLHTQNTSLINTK-------KKLETDISQIQGEMEDIIQEAR 1753
Query: 987 LLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE--GFQKPS 1044
++ + + EL +E+ LE K +LE+ KDL+ RL +E +
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK 1813
Query: 1045 ASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHV---NDQKD 1101
+ +LE++ + L+ +++E++ RK ERKVKEL+ Q E++R+++ D D
Sbjct: 1814 KQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVD 1873
Query: 1102 QLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDS 1156
+L +VK+ KRQ +EAEE+ ++ Q E+EE E + ++++ L S
Sbjct: 1874 KLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKS 1928
Score = 148 bits (374), Expect = 3e-35
Identities = 199/916 (21%), Positives = 383/916 (41%), Gaps = 135/916 (14%)
Query: 329 SETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPS 388
++T +RK + EKM L+ + V + + EE + D+ +K + +LE
Sbjct: 868 AKTEAKRKE--LEEKMVTLMQEKNDLQLQVQAEADSLADAEE---RCDQLIKTKIQLEAK 922
Query: 389 QVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMEL 448
+ + E++ E + L + + E + K++ +++ L + E +H E +V
Sbjct: 923 IKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV--- 979
Query: 449 QNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLR-------ERELTALK 501
+N + + G + L K+ +E ++ L+ Q E+++ E+++ L+
Sbjct: 980 KNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLE 1039
Query: 502 GALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQREL 561
G+L++E R ++E +++ + D + + S D D L+ + +K + GLQ ++
Sbjct: 1040 GSLEQEKKIR-MDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKI 1098
Query: 562 EETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARAS- 620
E+ L M+ ++ +EL +IE L+ E+E RAS
Sbjct: 1099 EDEQA-------------------------LGMQLQKKIKELQARIEELEEEIEAERASR 1133
Query: 621 AGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELE 680
A +Q L +EL E L+E +Q + R+ E +K R+LE
Sbjct: 1134 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMR----------RDLE 1183
Query: 681 EQNLQLQKTLQQLR-----------QDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQ 729
E LQ + T LR + + + K E E + + + + +
Sbjct: 1184 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVS 1243
Query: 730 EENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEG 789
+ + LE QL E + + + + L + RL+ E + L+
Sbjct: 1244 KAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVS 1303
Query: 790 SLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDR 849
L+ K+A ++EE +R L + + L AL+ ++LR E +E K L R
Sbjct: 1304 QLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQR 1363
Query: 850 TVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLS 909
+ + N E+ + + Q +LE+ K+K + + DA+ + ++
Sbjct: 1364 AMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQ 1423
Query: 910 RLQDEIQRLRQALQASQAERDTARLDK------ELLAQRLQGLEQ-----EAENKK-RSQ 957
RLQ+E++ L ++ + A A LDK ++LA+ Q E+ EA K+ RS
Sbjct: 1424 RLQNEVEDLMIDVERTNAA--CAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSL 1481
Query: 958 DDRARQLK-GLEEKVSRLETELDEEKN---TVELLTDRVNRGRDQV---DQLRTELMQER 1010
++K EE + +LET E KN + LT+++ G ++ ++++ ++ QE+
Sbjct: 1482 STELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEK 1541
Query: 1011 SARQ-DLECDKISLE-RQNKDLKTRL----ASSEGFQKPSASLSQLESQN-------QLL 1057
S Q LE + SLE + K L+ +L SE +K + +++ + +
Sbjct: 1542 SELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESM 1601
Query: 1058 QERLQAEEREKTVLQSTNRKLERKVKELSIQ---------------------IEDERQHV 1096
Q L AE R + +K+E + E+ IQ ++D + H+
Sbjct: 1602 QSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHL 1661
Query: 1097 NDQ-------KDQLSL---RVKALKRQVDEAEEEIERLDGLRKKAQRE-------VEEQH 1139
+D K+QL++ R L+ +++E +E+ + RK A++E V+ H
Sbjct: 1662 DDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLH 1721
Query: 1140 EVNEQLQARIKSLEKD 1155
N L K LE D
Sbjct: 1722 TQNTSLINTKKKLETD 1737
Score = 127 bits (318), Expect = 8e-29
Identities = 155/763 (20%), Positives = 329/763 (43%), Gaps = 107/763 (14%)
Query: 509 ASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEET 568
A ++E+ ++++++++ E+L ++ + + Q+ + L +Q E + ++
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAE 906
Query: 569 GHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTR-QV 627
+ K K L A +E+ + ++EE+ EL K L+ E + + D +
Sbjct: 907 ERCDQLI-KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965
Query: 628 EVLKKELLRTQEELKELQAERQS--QEVAGRHRDREL-----EKQLAVLRVEADRGRELE 680
++KE T+ ++K L E + +A ++++ ++ L L+ E D+ L
Sbjct: 966 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1025
Query: 681 EQNLQLQKTLQQLRQDCEEASKAKMVAE-AEATVLGQRRAAVETTLRETQEENDEFRRRI 739
+ ++L++ + L E+ K +M E A+ + G + A E+T+ + + + + ++
Sbjct: 1026 KAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTM-DIENDKQQLDEKL 1084
Query: 740 LGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALE 799
E ++ + ++ +A+ +L+ K++ L+A ++LEE + A +RA
Sbjct: 1085 KKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEA-----------ERASR 1133
Query: 800 ARLEEAQRGLARLGQEQQTLNRALEEEG----KQREVLRRGKAELEEQKRLLDRTV---D 852
A+ E+ + L+R E + ++ LEE G Q E+ ++ +AE ++ +R L+ +
Sbjct: 1134 AKAEKQRSDLSR---ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHE 1190
Query: 853 RLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQ 912
L K DS L + L+ K+K +E ++ + + D AS E S L+
Sbjct: 1191 ATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLE 1250
Query: 913 DEIQRLRQAL-QASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDR-------ARQL 964
+ L L + E + RL +L AQR + L+ E+ R D++ +R
Sbjct: 1251 KMCRALEDQLSEIKTKEEEQQRLINDLTAQRAR-LQTESGEYSRQLDEKDTLVSQLSRGK 1309
Query: 965 KGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDL-------- 1016
+ +++ L+ +L+EE L + R D LR + +E+ A+ +L
Sbjct: 1310 QAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKAN 1369
Query: 1017 ----------ECDKISLERQNKDLKTRLA-----SSEGFQKPSASLSQLESQNQLLQ--- 1058
E D I + ++ K +LA + E + +A + LE Q LQ
Sbjct: 1370 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEV 1429
Query: 1059 ------------------------ERLQAEEREKTVLQSTNRKLERKVKELS------IQ 1088
+++ AE ++K + T+ +LE KE +
Sbjct: 1430 EDLMIDVERTNAACAALDKKQRNFDKILAEWKQKC--EETHAELEASQKESRSLSTELFK 1487
Query: 1089 IEDERQHVNDQKDQLSLRVKALKRQVDEAEEEI----ERLDGLRKKAQREVEEQHEVNEQ 1144
I++ + DQ + L K L++++ + E+I +R+ L K ++ +E+ E+
Sbjct: 1488 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAA 1547
Query: 1145 LQARIKSLEKDSWR----KASRSAAESALKNEGLSSDEEFDSV 1183
L+ SLE + + + + +S + + DEE D +
Sbjct: 1548 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQM 1590
Score = 123 bits (308), Expect = 1e-27
Identities = 134/601 (22%), Positives = 270/601 (44%), Gaps = 63/601 (10%)
Query: 606 KIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQ 665
KI+ L + E + A + E K+EL +T+ + KEL E + + D +L+ Q
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKEL--EEKMVTLMQEKNDLQLQVQ 896
Query: 666 LAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTL 725
EAD + EE+ QL KT QL +E ++ E L ++ +E
Sbjct: 897 -----AEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 951
Query: 726 RETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEA----- 780
E +++ D+ + +E++ T V A L + + +L EK+ L+EA
Sbjct: 952 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTL 1011
Query: 781 --LNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKA 838
L A +++ +L AK LE ++++ + L + + + L RA + ++ +
Sbjct: 1012 DDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTM 1071
Query: 839 ELEEQKRLLDRTVDRLNKELEKIGEDSK------------QALQQLQAQLEDYKEKARRE 886
++E K+ LD + + KE E G SK + +++LQA++E+ +E+ E
Sbjct: 1072 DIENDKQQLDEKLKK--KEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAE 1129
Query: 887 VAD---AQRQAKDWASEAEKTS------GGLSRLQDEIQRLRQA-LQASQAERDTARLDK 936
A A++Q D + E E+ S GG + Q E+ + R+A Q + + + A L
Sbjct: 1130 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQH 1189
Query: 937 ELLAQRLQGLEQEAENKKRSQDDRARQLKG-LEEKVSRLETELDEEKNTVELLT------ 989
E A L+ ++ + Q D +++K LE++ S ++ E+D+ + +E ++
Sbjct: 1190 EATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNL 1249
Query: 990 DRVNRG-RDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGF-----QKP 1043
+++ R DQ+ +++T+ +++ DL + L+ ++ + +L + +
Sbjct: 1250 EKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGK 1309
Query: 1044 SASLSQLESQNQLLQERLQAEEREKTVLQSTN------RKLERKVKELSIQIEDERQHVN 1097
A Q+E + L+E ++A+ LQS+ R+ + +E +++ N
Sbjct: 1310 QAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKAN 1369
Query: 1098 DQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSW 1157
+ Q + + +A + E L+ +KK + +++ E E + A+ SLEK
Sbjct: 1370 SEVAQWRTKYET------DAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQ 1423
Query: 1158 R 1158
R
Sbjct: 1424 R 1424
Score = 121 bits (304), Expect = 3e-27
Identities = 171/915 (18%), Positives = 368/915 (40%), Gaps = 169/915 (18%)
Query: 255 QNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHM 314
Q + L G S + + + E +R + L +ST D+ D+Q+
Sbjct: 1033 QQVDDLEG---SLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEF 1089
Query: 315 KATIYGILREGSSESETSVRRKVSLV---LEKMQPLVMVSSGS-TKAVAGQGELTRKVEE 370
+ + E +++K+ + +E+++ + S KA + +L+R++EE
Sbjct: 1090 EMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1149
Query: 371 LQRKLDE-------EVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEA-QQSNK 422
+ +L+E +++ +K E + R LEE T + L ++ ++ + +
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1209
Query: 423 ELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEG 482
++ N++R+ + E + ++ ++ +L + ++ V + E + + L + ++ E
Sbjct: 1210 QIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEE 1269
Query: 483 KQRVEEQLRLRERELTALKGALKEEVASRD--------------QEVEHVRQQYQRDTEQ 528
+QR+ L + L G ++ +D Q++E +++Q + + +
Sbjct: 1270 QQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKA 1329
Query: 529 ---LRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQ----KNKED 581
L ++Q + D +L + ++ LQR + + + E W++ ++ + E+
Sbjct: 1330 KSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEE 1389
Query: 582 LRATKQELLQLRMEKEEMEEELGEKI-------EVLQRELEQ---------ARASAGDTR 625
L K++L Q + EE E + K + LQ E+E A +A D +
Sbjct: 1390 LEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKK 1449
Query: 626 QVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQ 685
Q K L +++ +E AE ++ + R EL K D+ L+ +N
Sbjct: 1450 QRN-FDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKN 1508
Query: 686 LQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQ 745
LQ+ + L + E K E + Q ++ ++ L E + + +IL ++ +
Sbjct: 1509 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLE 1568
Query: 746 LKETRGLVDGGEAVEARLRDKLQR------------LEAEKQQLEEALNASQEEEGSLAA 793
L + + VD A + D+++R L+AE + +A+ ++ EG L
Sbjct: 1569 LNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDL-- 1626
Query: 794 AKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDR 853
+E +L A R A + + L++ + R + +L+EQ +++R +
Sbjct: 1627 --NEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANL 1684
Query: 854 LNKELE-------------KIGE----DSKQALQ---------------------QLQAQ 875
L E+E KI E D+ + +Q Q+Q +
Sbjct: 1685 LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGE 1744
Query: 876 LEDY-------KEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQ----- 923
+ED +EKA++ + DA A++ E + TS L R++ +++ + LQ
Sbjct: 1745 MEDIIQEARNAEEKAKKAITDAAMMAEELKKEQD-TSAHLERMKKNLEQTVKDLQHRLDE 1803
Query: 924 ASQAERDTARLDKELLAQRLQGLEQEAENKKR----------------------SQDDRA 961
A Q + + L R++ LE E E++++ +++DR
Sbjct: 1804 AEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRK 1863
Query: 962 --------------------RQLKGLEE-------KVSRLETELDEEKNTVELLTDRVNR 994
RQ + EE K R++ EL+E + ++ +VN+
Sbjct: 1864 NILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNK 1923
Query: 995 GRDQVDQLRTELMQE 1009
R + ++ T+++ E
Sbjct: 1924 LRVKSREVHTKIISE 1938
Score = 88.6 bits (218), Expect = 3e-17
Identities = 95/431 (22%), Positives = 194/431 (45%), Gaps = 28/431 (6%)
Query: 735 FRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQ-QLEEALNASQEEEGSLAA 793
F+ +LGL +++++ + L +A R L R+E +K + E++ Q +
Sbjct: 769 FKAGLLGLLEEMRDEK-LAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAFMN 827
Query: 794 AKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEE-QKRLLDRTVD 852
K +L + L + + ++ + EE K +E L + +A+ +E +++++ +
Sbjct: 828 VKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQE 887
Query: 853 RLNKELEKIGE-DSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRL 911
+ + +L+ E DS ++ QL K + ++ + +A+D + + +L
Sbjct: 888 KNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKL 947
Query: 912 QDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKV 971
+DE L++ + + +K +++ L +E + ++ K L+E
Sbjct: 948 EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1007
Query: 972 SRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLK 1031
+ +L E++ V LT + QVD L L QE+ R DLE K LE DLK
Sbjct: 1008 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEG---DLK 1064
Query: 1032 TRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQST-------NRKLERKVKE 1084
S+ +E+ Q L E+L+ +E E + LQS +L++K+KE
Sbjct: 1065 LAQEST----------MDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKE 1114
Query: 1085 LSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQ 1144
L +IE+ + + ++ + R KA K++ D E+E + ++A Q E+N++
Sbjct: 1115 LQARIEELEEEIEAER---ASRAKAEKQRSD-LSRELEEISERLEEAGGATSAQIEMNKK 1170
Query: 1145 LQARIKSLEKD 1155
+A + + +D
Sbjct: 1171 REAEFQKMRRD 1181
Score = 61.2 bits (147), Expect = 6e-09
Identities = 62/292 (21%), Positives = 125/292 (42%), Gaps = 26/292 (8%)
Query: 879 YKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKEL 938
+K K + A+ +++ + E EKT L++ + + + L + + E++ +L +
Sbjct: 838 FKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQA 897
Query: 939 LAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQ 998
A L E+ + +++ ++K + E+ DEE+ EL T + + D+
Sbjct: 898 EADSLADAEERCDQLIKTKIQLEAKIKEVTERAE------DEEEINAEL-TAKKRKLEDE 950
Query: 999 VDQLRTELMQERSARQDLECDKISLERQNKDLKTRLAS-SEGFQKPSASLSQLESQNQLL 1057
+L+ ++ +E +K + E + K+L +A E K + L+ +Q
Sbjct: 951 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1010
Query: 1058 QERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEA 1117
+ LQAEE + L KLE++V +L +E E K ++ ++ A
Sbjct: 1011 LDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE---------------KKIRMDLERA 1055
Query: 1118 EEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESAL 1169
+ ++E G K AQ + +QL ++K E + S+ E AL
Sbjct: 1056 KRKLE---GDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQAL 1104
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 179 bits (454), Expect = 1e-44
Identities = 181/829 (21%), Positives = 367/829 (44%), Gaps = 49/829 (5%)
Query: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 422
EL ++EEL+ +++ E R K E + L R+LEE +E RL+E + + + K
Sbjct: 1114 ELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISE---RLEEAGGATSAQIEMNKK 1170
Query: 423 ---ELQNMKRLLDQGE--------DLRHGLETQVMELQNKLKHVQGP----EPAKEVLLK 467
E Q M+R L++ LR V EL ++ +Q E K L
Sbjct: 1171 REAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKM 1230
Query: 468 DLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASR-DQEVEHVRQQYQRDT 526
++ + +E V + K E+ R E +L+ +K KEE R E+ + + ++
Sbjct: 1231 EINDLASNMETVSKAKANFEKMCRTLEDQLSEIK--TKEEEQQRLINELSAQKARLHTES 1288
Query: 527 EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATK 586
+ R + + + L +Q + + L+R+LEE ++ Q + D +
Sbjct: 1289 GEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLR 1348
Query: 587 QELLQLRMEKEEMEEELGE-KIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQ 645
++ + + K E++ + + EV Q + + T ++E KK+L + ++ +E
Sbjct: 1349 EQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHV 1408
Query: 646 AERQSQEVAGRHRDRELEKQLAVLRVEADRGRE----LEEQNLQLQKTLQQLRQDCEEAS 701
S+ + + L+ ++ L ++ +R L+++ K L + +Q EE
Sbjct: 1409 EAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQ 1468
Query: 702 KAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKE-TRGLVDGGEAVE 760
++ E+ L V+ E+ + + +R L+Q++ + T + +GG+ +
Sbjct: 1469 AELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIH 1528
Query: 761 ARLRDKLQRLEAEKQQL----EEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQ 816
+ K Q L+ EK +L EEA + + EEG + + L E R +A +E
Sbjct: 1529 ELEKVKKQ-LDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEL 1587
Query: 817 QTLNR----ALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQL 872
L R +E + R + + K+ ++ ++ + +L + +AL+ L
Sbjct: 1588 DQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNL 1647
Query: 873 QAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTA 932
+ + + + + DA R D + + +Q E++ LR +L+ ++ R A
Sbjct: 1648 R-NTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMA 1706
Query: 933 RLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRV 992
+ ++R+Q L + + ++ K LE +S+++ E+++ ++
Sbjct: 1707 EQELLDASERVQLLHTQNTSLINTK-------KKLETDISQIQGEMEDIVQEARNAEEKA 1759
Query: 993 NRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE--GFQKPSASLSQL 1050
+ + EL +E+ LE K ++E+ KDL+ RL +E + + +L
Sbjct: 1760 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKL 1819
Query: 1051 ESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHV---NDQKDQLSLRV 1107
E++ + L+ +++E++ RK ER+VKEL+ Q E++R+++ D D+L +V
Sbjct: 1820 EARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKV 1879
Query: 1108 KALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDS 1156
KA KRQ +EAEE+ +K Q E+EE E + ++++ L S
Sbjct: 1880 KAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKS 1928
Score = 154 bits (388), Expect = 6e-37
Identities = 197/913 (21%), Positives = 374/913 (40%), Gaps = 129/913 (14%)
Query: 329 SETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPS 388
++T +RK + EKM L+ + V + + EE + D+ +K + +LE
Sbjct: 868 AKTEAKRKE--LEEKMVTLMQEKNDLQLQVQAEADALADAEE---RCDQLIKTKIQLEAK 922
Query: 389 QVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMEL 448
+ + E++ E + L + + E + K++ +++ L + E +H E +V
Sbjct: 923 IKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV--- 979
Query: 449 QNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEV 508
+N + + G + L K+ +E ++ L+ Q E+++ + T L+ + +
Sbjct: 980 KNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLE 1039
Query: 509 ASRDQE------VEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELE 562
S +QE +E +++ + D + + S D D L + +K + LQ ++E
Sbjct: 1040 GSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIE 1099
Query: 563 ETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARAS-A 621
+ ++ L ++++K+ +EL +IE L+ E+E RAS A
Sbjct: 1100 D-----------------------EQALAIQLQKKI--KELQARIEELEEEIEAERASRA 1134
Query: 622 GDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEE 681
+Q L +EL E L+E +Q + R+ E +K R+LEE
Sbjct: 1135 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMR----------RDLEE 1184
Query: 682 QNLQLQKTLQQLR-----------QDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQE 730
LQ + T LR + + + K E E + L + + + +
Sbjct: 1185 STLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSK 1244
Query: 731 ENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGS 790
F + LE QL E + + + + L + RL E + L+
Sbjct: 1245 AKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQ 1304
Query: 791 LAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRT 850
L+ K+A ++EE +R L + + TL AL+ ++LR E +E K L R
Sbjct: 1305 LSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRG 1364
Query: 851 VDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSR 910
+ + N E+ + + Q +LE+ K+K + + DA+ + S+ R
Sbjct: 1365 MSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQR 1424
Query: 911 LQDEIQRLRQALQASQA-----ERDTARLDKELLAQRLQGLEQEAENKKRSQDDRA---- 961
LQ+E++ L ++ S A ++ DK L + + E +AE + ++ R+
Sbjct: 1425 LQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTE 1484
Query: 962 --RQLKGLEEKVSRLETELDEEKN---TVELLTDRVNRGRDQVDQL---RTELMQERSAR 1013
+ EE + LET E KN + LT+++ G + +L + +L E+S
Sbjct: 1485 LFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSEL 1544
Query: 1014 Q-DLECDKISLE-RQNKDLKTRLASSE-------GFQKPSASLSQLESQN----QLLQER 1060
Q LE + SLE + K L+ +L ++ + L QL+ + + +Q
Sbjct: 1545 QTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQST 1604
Query: 1061 LQAEEREKTVLQSTNRKLERKVKELSIQ---------------------IEDERQHVNDQ 1099
L AE R + +K+E + E+ IQ ++D + H++D
Sbjct: 1605 LDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDA 1664
Query: 1100 -------KDQLSL---RVKALKRQVDEAEEEIERLDGLRKKAQRE-------VEEQHEVN 1142
K+QL++ R ++ +V+E +ER + RK A++E V+ H N
Sbjct: 1665 IRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQN 1724
Query: 1143 EQLQARIKSLEKD 1155
L K LE D
Sbjct: 1725 TSLINTKKKLETD 1737
Score = 149 bits (375), Expect = 2e-35
Identities = 212/963 (22%), Positives = 407/963 (42%), Gaps = 130/963 (13%)
Query: 328 ESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEP 387
+++ + K+ V E+ + +++ T A + +L + EL++ +D+ K+E
Sbjct: 914 KTKIQLEAKIKEVTERAEDEEEINAELT---AKKRKLEDECSELKKDIDDLELTLAKVEK 970
Query: 388 SQVGLERQLEEKTEECSRLQELLERRKGEA-------QQSNKELQNMKRLLDQGEDLRHG 440
+ E +++ TEE + L E + + E QQ+ +LQ + ++ +
Sbjct: 971 EKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTK 1030
Query: 441 LETQVMELQNKL----KHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERE 496
LE QV +L+ L K E AK L DL +E + KQ++ E+L+ +E E
Sbjct: 1031 LEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFE 1090
Query: 497 LTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRG 556
++ L+G +++E A Q + +++ R E+L ++ A E +R +S +
Sbjct: 1091 MSNLQGKIEDEQALAIQLQKKIKELQAR-IEELEEEIEAERASRAKAEKQRSDLSRELEE 1149
Query: 557 LQRELEETSEETGHWQSMFQKNKEDLRATKQELLQ-----------LRMEKEEMEEELGE 605
+ LEE T M +K + + + +++L + LR + + ELGE
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGE 1209
Query: 606 KIEVLQR---ELEQ-------------------ARASAGDTRQVEVLKKEL--LRTQEE- 640
+I+ LQR +LE+ ++A A + L+ +L ++T+EE
Sbjct: 1210 QIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEE 1269
Query: 641 ----LKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRE-----LEEQNLQLQK--- 688
+ EL A++ R+L+++ A++ + RG++ +EE QL++
Sbjct: 1270 QQRLINELSAQKARLHTESGEFSRQLDEKDAMVS-QLSRGKQAFTQQIEELKRQLEEETK 1328
Query: 689 -------TLQQLRQDCE---EASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRR 738
LQ R DC+ E + + A+AE G +A E T+ E D +R
Sbjct: 1329 AKSTLAHALQSARHDCDLLREQYEEEQEAKAELQ-RGMSKANSEVAQWRTKYETDAIQRT 1387
Query: 739 ILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRAL 798
E + K + L D E VEA + K LE KQ+L+ + + AA AL
Sbjct: 1388 EELEEAKKKLAQRLQDAEEHVEA-VNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIAL 1446
Query: 799 EARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKEL 858
+ + + LA Q+ + LE K+ L EL + K + ++D L + L
Sbjct: 1447 DKKQRNFDKVLAEWKQKYEETQAELEASQKESRSL---STELFKVKNAYEESLDHL-ETL 1502
Query: 859 EKIGEDSKQALQQLQAQ----------LEDYKEKARREVADAQRQAKDWASEAEKTSGGL 908
++ ++ +Q + L Q LE K++ E ++ Q ++ + E G +
Sbjct: 1503 KRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKI 1562
Query: 909 SRLQDEIQRLRQALQASQAERDTARLD--KELLAQRLQGLEQEAENKKRSQDDRARQLKG 966
R+Q E+ +++ + AE+D LD K + ++ ++ + + RS++D R K
Sbjct: 1563 LRIQLELNQVKSEIDRKIAEKDE-ELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKK 1621
Query: 967 LEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQ 1026
+E ++ +E +L N Q + L + +D + R
Sbjct: 1622 MEGDLNEMEIQL--------------NHANRQAAEALRNLRNTQGILKDTQLHLDDAIRG 1667
Query: 1027 NKDLKTRLASSEG--------FQKPSASLSQLESQNQLL-QERLQAEER------EKTVL 1071
DLK +LA E ++ ASL + E ++ QE L A ER + T L
Sbjct: 1668 QDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSL 1727
Query: 1072 QSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEA--EEEIERLDGLRK 1129
+T +KLE + ++ ++ED Q + ++ KA K D A EE+++
Sbjct: 1728 INTKKKLETDISQIQGEMEDIVQEARNAEE------KAKKAITDAAMMAEELKKEQDTSA 1781
Query: 1130 KAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSI 1189
+R + + + LQ R+ E+ + + + + + L S+ E + ++ ++
Sbjct: 1782 HLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAV 1841
Query: 1190 ASL 1192
L
Sbjct: 1842 KGL 1844
Score = 132 bits (331), Expect = 3e-30
Identities = 177/924 (19%), Positives = 373/924 (40%), Gaps = 171/924 (18%)
Query: 247 TSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQEAA 306
T + Q + L G S + + + E +R + L +ST D D+Q+
Sbjct: 1025 TKAKTKLEQQVDDLEG---SLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLN 1081
Query: 307 PPGSVDHMKATIYGILR-EGSSESETSVRRKVSLVLEKMQPLV--------MVSSGSTKA 357
+ +K + + +G E E ++ ++ ++++Q + + KA
Sbjct: 1082 -----EKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKA 1136
Query: 358 VAGQGELTRKVEELQRKLDE-------EVKKRQKLEPSQVGLERQLEEKTEECSRLQELL 410
+ +L+R++EE+ +L+E +++ +K E + R LEE T + L
Sbjct: 1137 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAAL 1196
Query: 411 ERRKGEA-QQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDL 469
++ ++ + +++ +++R+ + E + L+ ++ +L + ++ V + E + + L
Sbjct: 1197 RKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTL 1256
Query: 470 LETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRD--------------QEV 515
+ ++ E +QR+ +L ++ L G ++ +D Q++
Sbjct: 1257 EDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQI 1316
Query: 516 EHVRQQYQRDTEQ---LRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQ 572
E +++Q + +T+ L ++Q A D +L + ++ LQR + + + E W+
Sbjct: 1317 EELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWR 1376
Query: 573 SMFQ----KNKEDLRATKQELLQLRMEKEEMEEELGEK--------------IEVLQREL 614
+ ++ + E+L K++L Q + EE E + K +E L ++
Sbjct: 1377 TKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDV 1436
Query: 615 EQARAS--AGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVE 672
E++ A+ A D +Q K L +++ +E QAE ++ + R EL K
Sbjct: 1437 ERSNAACIALDKKQRN-FDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEES 1495
Query: 673 ADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEEN 732
D L+ +N LQ+ + L + E K E L ++ ++T+L E +
Sbjct: 1496 LDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASL 1555
Query: 733 DEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQR------------LEAEKQQLEEA 780
+ +IL ++ +L + + +D A + D+L+R L+AE + +A
Sbjct: 1556 EHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDA 1615
Query: 781 LNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRA---LEEEGKQREVLRRGK 837
L ++ EG L + L +A L L Q L L++ + ++ L+
Sbjct: 1616 LRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQL 1675
Query: 838 AELEEQKRLLDRTVDRLNKELEKIGEDSKQALQ--------------------------- 870
A +E + L+ V+ L LE+ K A Q
Sbjct: 1676 AMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLE 1735
Query: 871 ----QLQAQLEDY-------KEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLR 919
Q+Q ++ED +EKA++ + DA A++ E + TS L R++ +++
Sbjct: 1736 TDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQD-TSAHLERMKKNMEQTV 1794
Query: 920 QALQ-----ASQAERDTARLDKELLAQRLQGLEQEAENKKR------------------- 955
+ LQ A Q + + L R++ LE E E++++
Sbjct: 1795 KDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKEL 1854
Query: 956 ---SQDDRA--------------------RQLKGLEE-------KVSRLETELDEEKNTV 985
+++DR RQ + EE K +L+ EL+E K
Sbjct: 1855 TYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERA 1914
Query: 986 ELLTDRVNRGRDQVDQLRTELMQE 1009
++ +VN+ R + ++ T+++ E
Sbjct: 1915 DIAESQVNKLRVKSREVHTKVISE 1938
Score = 124 bits (312), Expect = 4e-28
Identities = 143/659 (21%), Positives = 291/659 (44%), Gaps = 76/659 (11%)
Query: 563 ETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELE----QAR 618
ET +E + + F+K KE+L T E +EL EK+ L +E Q +
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKT-----------EAKRKELEEKMVTLMQEKNDLQLQVQ 896
Query: 619 ASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRD-RELEKQLAVLRVEADRGR 677
A A E +L++T ++Q E + +EV R D E+ +L + R
Sbjct: 897 AEADALADAEERCDQLIKT-----KIQLEAKIKEVTERAEDEEEINAELTA------KKR 945
Query: 678 ELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEE----ND 733
+LE++ +L+K + L + K K E + L + A ++ T+ + +E +
Sbjct: 946 KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1005
Query: 734 EFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAA 793
++ + L+ + + L +E ++ D LE EK+ + A ++ EG L
Sbjct: 1006 AHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKL 1065
Query: 794 AKRA------------------------LEARLEEAQRGLARLGQEQQTLNRALEEEGKQ 829
A+ + L+ ++E+ Q +L ++ + L +EE ++
Sbjct: 1066 AQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEE 1125
Query: 830 REVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVAD 889
E R +A+ E+Q+ L R ++ +++ LE+ G + A ++ + E +K RR++ +
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISERLEEAG-GATSAQIEMNKKREAEFQKMRRDLEE 1184
Query: 890 AQRQAKDWASE-AEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQ 948
+ Q + A+ +K + ++ L ++I L++ Q + E+ +++ LA ++ + +
Sbjct: 1185 STLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSK 1244
Query: 949 EAENKK---RSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTE 1005
N + R+ +D+ ++K EE+ RL EL +K + + +R D+ D + ++
Sbjct: 1245 AKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQ 1304
Query: 1006 LMQERSA-RQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAE 1064
L + + A Q +E K LE + K K+ LA +L LL+E+ + E
Sbjct: 1305 LSRGKQAFTQQIEELKRQLEEETK-AKSTLAH---------ALQSARHDCDLLREQYEEE 1354
Query: 1065 EREKTVLQSTNRKLERKVKELSIQIEDE----RQHVNDQKDQLSLRVKALKRQVDEAEEE 1120
+ K LQ K +V + + E + + + + K +L+ R++ + V+ +
Sbjct: 1355 QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSK 1414
Query: 1121 IERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEE 1179
L+ +++ Q EVE+ E+ A +L+K R + AE K E ++ E
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQ-RNFDKVLAEWKQKYEETQAELE 1472
Score = 123 bits (309), Expect = 9e-28
Identities = 195/885 (22%), Positives = 366/885 (41%), Gaps = 159/885 (17%)
Query: 343 KMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVK---KRQKLEPSQVGLERQ---- 395
K++PL+ K+ + E+ EE ++ +E K KR++LE V L ++
Sbjct: 839 KIKPLL-------KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDL 891
Query: 396 ----------LEEKTEECSRL-----------QELLERRKGEAQQSNKELQNMKRLLDQG 434
L + E C +L +E+ ER + E ++ N EL KR L
Sbjct: 892 QLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDE-EEINAELTAKKRKL--- 947
Query: 435 EDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRE 494
ED L+ + +L+ L V+ + A E +K+L E L+E + + +E+ L+E
Sbjct: 948 EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIA--KLTKEKKALQE 1005
Query: 495 RELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALV 554
L EE + + + + ++ + L S++ + LE ++K+ +
Sbjct: 1006 AHQQTLDDLQMEE--DKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDL 1063
Query: 555 RGLQRELEETSEETGHWQSMFQKNK---EDLRATKQELLQLRMEKEEMEEELGEKIEVLQ 611
+ Q +T + +K + +L+ ++ L ++ ++ +EL +IE L+
Sbjct: 1064 KLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELE 1123
Query: 612 RELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRV 671
E+E RAS + E + +L R EE+ E E A +++ E + +R
Sbjct: 1124 EEIEAERASRA---KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMR- 1179
Query: 672 EADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEE 731
R+LEE LQ + T LR+ A VAE LG++ +++ ++ ++E
Sbjct: 1180 -----RDLEESTLQHEATAAALRK-----KHADSVAE-----LGEQIDSLQRVKQKLEKE 1224
Query: 732 NDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSL 791
E + I L ++ E + L D+L ++ ++++ + +N ++ L
Sbjct: 1225 KSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARL 1284
Query: 792 AAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTV 851
+L+E +++L + +Q + +EE +Q E + K+ L +
Sbjct: 1285 HTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDC 1344
Query: 852 DRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRL 911
D L ++ E+ Q+ +A+L+ KA EVA W ++ E
Sbjct: 1345 DLLREQYEEE--------QEAKAELQRGMSKANSEVAQ-------WRTKYET-------- 1381
Query: 912 QDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQ--EAENKKRSQDDRARQLKGLEE 969
D IQR + +A K+ LAQRLQ E+ EA N K + ++ +Q
Sbjct: 1382 -DAIQRTEELEEA-----------KKKLAQRLQDAEEHVEAVNSKCASLEKTKQ------ 1423
Query: 970 KVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKD 1029
RL+ E+++ VE R N +D+ + DK+ E + K
Sbjct: 1424 ---RLQNEVEDLMIDVE----RSNAACIALDKKQRNF------------DKVLAEWKQKY 1464
Query: 1030 LKTRLASSEGFQKPSASLS-QLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQ 1088
+T+ A E QK S SLS +L +E L E L+ N+ L++++ +L+ Q
Sbjct: 1465 EETQ-AELEASQKESRSLSTELFKVKNAYEESLDHLE----TLKRENKNLQQEISDLTEQ 1519
Query: 1089 IEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEE-----QHEVNE 1143
I + +H++ E E+ ++LD + + Q +EE +HE +
Sbjct: 1520 IAEGGKHIH------------------ELEKVKKQLDHEKSELQTSLEEAEASLEHEEGK 1561
Query: 1144 --QLQARIKSLEKDSWRKASRSAAE-SALKNEGLSSDEEFDSVYD 1185
++Q + ++ + RK + E LK L E S D
Sbjct: 1562 ILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLD 1606
Score = 72.0 bits (175), Expect = 3e-12
Identities = 105/488 (21%), Positives = 199/488 (40%), Gaps = 92/488 (18%)
Query: 770 LEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQ----------------RGLARLG 813
L A+ +Q + LNAS EG +K+A E L + GL LG
Sbjct: 718 LYADFKQRYKVLNASAIPEGQFIDSKKASEKLLGSIEIDHTQYKFGHTKVFFKAGL--LG 775
Query: 814 QEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVD----RLN-------------- 855
++ + L + + + + RG E +++++R + N
Sbjct: 776 TLEEMRDEKLAQLITRTQAICRGFLMRVEFRKMMERRESIFCIQYNIRAFMNVKHWPWMK 835
Query: 856 -----KELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSR 910
K L K E K+ A +++ EK + E+A + + K+ + +
Sbjct: 836 LYFKIKPLLKSAETEKE-----MANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKND 890
Query: 911 LQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEK 970
LQ ++Q AL ++ D K L +++ + + AE+++ + + + LE++
Sbjct: 891 LQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 950
Query: 971 VSRLETELDE----------EKNTVELLTDRVNRGRDQVDQLRTELMQERSARQD----- 1015
S L+ ++D+ EK+ E + +D+ +L +E+ A Q+
Sbjct: 951 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1010
Query: 1016 -----LECDKIS--------LERQNKDLKTRLASSEGF-QKPSASLSQLESQNQLLQERL 1061
+E DK++ LE+Q DL+ L + + +LE +L QE
Sbjct: 1011 LDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQEST 1070
Query: 1062 QAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEI 1121
E +K L +K E ++ L +IEDE+ QL ++K L+ +++E EEEI
Sbjct: 1071 MDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQA----LAIQLQKKIKELQARIEELEEEI 1126
Query: 1122 ERLDGLRKKAQRE----VEEQHEVNEQL---------QARIKSLEKDSWRKASRSAAESA 1168
E R KA+++ E E++E+L Q + + ++K R ES
Sbjct: 1127 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEST 1186
Query: 1169 LKNEGLSS 1176
L++E ++
Sbjct: 1187 LQHEATAA 1194
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 173 bits (439), Expect = 8e-43
Identities = 220/1009 (21%), Positives = 433/1009 (42%), Gaps = 81/1009 (8%)
Query: 200 RTRMLPPEQRKRSKSLDSRLPRDTFEERERQSTNHWTSSTKYDNHVGTSKQPAQSQNLSP 259
R R L E + K +D E+E+++T H + T + ++++S
Sbjct: 951 RGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNL-------TEEVEFLNEDISK 1003
Query: 260 LSGFSR-----SRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRD--QQEAAPPGSVD 312
L+ ++ +QT D + EE + S+ L+ + D L +QE + +
Sbjct: 1004 LNRAAKVVQEAHQQTLDDL--HMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCE 1061
Query: 313 HMKATIYGIL---REGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVE 369
+ G L RE E+S R + +K L ++S +L + V+
Sbjct: 1062 RELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVK 1121
Query: 370 ELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEA-------QQSNK 422
ELQ ++ + +K + ++ +ER+ + T++ + L E LE G + ++
Sbjct: 1122 ELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQET 1181
Query: 423 ELQNMKRLLDQGE--------DLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDL-LETR 473
+ Q + R +++ L+ + EL+ +++++Q + E DL LE
Sbjct: 1182 KFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVD 1241
Query: 474 ELL---EEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLR 530
+LL E++ K E+ L E L L ++V ++ + + ++ +
Sbjct: 1242 DLLTRVEQMTRAKANAEKLCTLYEERLHEATAKL-DKVTQLANDLAAQKTKLWSESGEFL 1300
Query: 531 RSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELL 590
R +++ L E+ + + L+ +LE+ ++ QK + D +++
Sbjct: 1301 RRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYE 1360
Query: 591 QLRMEKEEMEEELGE-KIEVLQRELEQARASAGDTRQVEVLKKEL-LRTQEELKEL---Q 645
+ + K E+ L + E++Q ++ T +E KKEL +R QE + +
Sbjct: 1361 EEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVAN 1420
Query: 646 AERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKM 705
A S E A EL L+ L L+++ LQ K L +Q EE+
Sbjct: 1421 ARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLD 1480
Query: 706 VAEAEATVLGQRRAAVETTLRET-------QEENDEFRRRILGLEQQLKETRGLVDGGEA 758
++ E L ++ T E+ + EN + I L Q++E + E
Sbjct: 1481 ASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEK 1540
Query: 759 VEARLRDKLQRLEAEKQQLEEALNASQEE----EGSLAAAKRALEARLEEAQRGLARLGQ 814
V+ + ++ ++ ++ E AL ++ + + L AK LE +L E + +
Sbjct: 1541 VKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRR 1600
Query: 815 EQQ----TLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQ 870
+QQ +L +L+ E K R + R K ++EE ++ + N+++ ++ ++L
Sbjct: 1601 KQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVS----EATKSLG 1656
Query: 871 QLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERD 930
QLQ Q++D + ++ D+ + D + S LQ E++ LR + Q ER
Sbjct: 1657 QLQIQIKDLQ----MQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQE--QTERG 1710
Query: 931 TARLDKELLAQRLQGLEQEAENKKRSQDDRA-RQLKGLEEKVSRLETELDEEKNTVELLT 989
++ELL E N +Q+ Q K LE V+R++ E +E +
Sbjct: 1711 RRLSEEELLEAT------ERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAE 1764
Query: 990 DRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE--GFQKPSASL 1047
++ + + L EL +++ LE + ++E+ DL+ RLA +E +
Sbjct: 1765 EKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQI 1824
Query: 1048 SQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVN---DQKDQLS 1104
+LES+ + L+ L+ E R Q R+LER +KEL+ Q E+++++++ Q D+L
Sbjct: 1825 QKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQ 1884
Query: 1105 LRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLE 1153
L+V+ K+QV+ AE + + KK Q E+ E E E ++++ L+
Sbjct: 1885 LKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLK 1933
Score = 139 bits (349), Expect = 2e-32
Identities = 208/946 (21%), Positives = 406/946 (42%), Gaps = 122/946 (12%)
Query: 287 PTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQP 346
P M F L++ + + A + L + + E ++VSL EK
Sbjct: 840 PWMRLFFKIKPLVKSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDL 899
Query: 347 LVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRL 406
++ + + + E VEE L +K + +LE L ++EE+ E S L
Sbjct: 900 ILQLQA--------EQETLANVEEQCEWL---IKSKIQLEARVKELSERVEEEEEINSEL 948
Query: 407 QELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGP-------- 458
+ + E + KE+ +++ +L + E + E +V L +++ +
Sbjct: 949 TARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAA 1008
Query: 459 ---EPAKEVLLKDLLETRELLEEV-------------LEGKQRVEEQLRLR-ERELTALK 501
+ A + L DL E L + LEG E + R+ EREL L+
Sbjct: 1009 KVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLE 1068
Query: 502 GALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQREL 561
G LK + +E++ + E+LR+ + +Q ++ +E E +GL +L
Sbjct: 1069 GNLK----LNRESMENLESSQRHLAEELRKKELELSQMNSKVENE--------KGLVAQL 1116
Query: 562 EETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASA 621
++T +E Q+ + KE L A + ++ E+ ++ ++L + E L+ + A
Sbjct: 1117 QKTVKEL---QTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQL 1173
Query: 622 GDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRD--RELEKQLAVLRVEADRGREL 679
T++ E ++L R EE L E S + RH D ELE Q+ L+ ++L
Sbjct: 1174 EITKKQETKFQKLHRDMEE-ATLHFETTSASLKKRHADSLAELEGQVENLQ---QVKQKL 1229
Query: 680 EEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRI 739
E+ LQ + L E+ ++AK AE T+ +R L E + D+ +
Sbjct: 1230 EKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEER-------LHEATAKLDKVTQ-- 1280
Query: 740 LGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALE 799
L + ++T+ + GE L+RLE EK+ L +N E+ + L
Sbjct: 1281 LANDLAAQKTKLWSESGEF--------LRRLE-EKEAL---INQLSREKSNFTRQIEDLR 1328
Query: 800 ARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELE 859
+LE+ + Q L AL++ + ++LR E +E K L RT+ ++N E+
Sbjct: 1329 GQLEKETK-------SQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMV 1381
Query: 860 KIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQ-RL 918
+ + + Q LED A++E+A ++A + A + L R + ++Q L
Sbjct: 1382 QWRMKYENNVIQRTEDLED----AKKELAIRLQEAAEAMGVANARNASLERARHQLQLEL 1437
Query: 919 RQAL-QASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETE 977
AL + ARLD+ ++LQ + A+ K++ ++ +A L +++V L TE
Sbjct: 1438 GDALSDLGKVRSAAARLDQ----KQLQSGKALADWKQKHEESQA-LLDASQKEVQALSTE 1492
Query: 978 LDEEKNTV-------ELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDL 1030
L + KNT E L ++++ L ++ + ++E K +E + ++
Sbjct: 1493 LLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEV 1552
Query: 1031 KTRLASSEGFQKPSAS------LSQLESQNQLLQERLQAEE-------REKTVLQSTNRK 1077
+ L +EG + + S L LE++ +L ++ + +E +++ + S
Sbjct: 1553 QVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSS 1612
Query: 1078 LERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEE 1137
L+ + K I++ ++ + + +++ L++ RQV EA + + +L K Q ++++
Sbjct: 1613 LDSEAKS-RIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDD 1671
Query: 1138 QHEVNEQLQARIKSLEK-----DSWRKASRSAAESALKNEGLSSDE 1178
++N L+ ++ E+ S + RS E + LS +E
Sbjct: 1672 STQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEE 1717
Score = 109 bits (272), Expect = 2e-23
Identities = 163/748 (21%), Positives = 309/748 (41%), Gaps = 107/748 (14%)
Query: 324 EGSSESETSVRRKVS-----LVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEE 378
EG E+ V++K+ L LE L V T+A A +L EE +L E
Sbjct: 1216 EGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQ-MTRAKANAEKLCTLYEE---RLHEA 1271
Query: 379 VKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLR 438
K K+ L Q + E LE ++ Q ++E N R Q EDLR
Sbjct: 1272 TAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTR---QIEDLR 1328
Query: 439 HGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELT 498
LE + Q+ L H A + +D RE EE E K + L E+
Sbjct: 1329 GQLEKETKS-QSALAH------ALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMV 1381
Query: 499 ALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMS------- 551
+ + V R +++E +++ ++ +M A +A LE R ++
Sbjct: 1382 QWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDAL 1441
Query: 552 ---ALVRGLQRELEETSEETGH----W-------QSMFQKNKEDLRATKQELLQLRMEKE 597
VR L++ ++G W Q++ ++++++A ELL+L+ E
Sbjct: 1442 SDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYE 1501
Query: 598 EM---EEELGEKIEVLQRELE----QARASAGDTRQVEVLKKELLRTQEELKELQAERQS 650
E +E L + + LQ E+ Q R + ++E +KK + +EE E+Q +
Sbjct: 1502 ESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLI---EEEKTEVQVTLEE 1558
Query: 651 QEVA-GRHRDRELEKQLAVLRVEADRGRELEEQNLQLQK-------TLQQLRQDCE---- 698
E A R+ + L QL +L +A+ R+L E++ +++ T+ L+ +
Sbjct: 1559 TEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAK 1618
Query: 699 ---EASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGL--- 752
E ++ K E + + + + + E + + + +I L+ QL ++ L
Sbjct: 1619 SRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSD 1678
Query: 753 ----VDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEE--------------EGSLAAA 794
V E + L+ +L+ L + ++Q E S+EE SL +
Sbjct: 1679 LKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQ 1738
Query: 795 KRALEARLEEAQRGLARLGQE----QQTLNRALEEEGKQREVLRRGK---AELEEQKRLL 847
K+ LEA + Q+ + QE ++ +A E E L++ + A LE + +
Sbjct: 1739 KKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENM 1798
Query: 848 DRTVDRLNKELEKIGE----DSKQALQQLQAQLEDYKEKARREV---ADAQRQA------ 894
++T+ L K L + + S++ +Q+L++++ + + + E+ A+AQR A
Sbjct: 1799 EQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERC 1858
Query: 895 -KDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENK 953
K+ +AE+ LSR+Q ++ +L+ +Q + + + A + + + E
Sbjct: 1859 IKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEV 1918
Query: 954 KRSQDDRARQLKGLEEKVSRLETELDEE 981
K + Q+ L+ K ++ EE
Sbjct: 1919 KERAEVAESQVNKLKIKAREFGKKVQEE 1946
Score = 40.8 bits (94), Expect = 0.008
Identities = 40/163 (24%), Positives = 78/163 (47%), Gaps = 20/163 (12%)
Query: 1050 LESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQ---HVNDQ------- 1099
L+ + LQ+ L+ E ++ L++ L ++ +L +Q++ E++ +V +Q
Sbjct: 864 LKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKS 923
Query: 1100 KDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRK 1159
K QL RVK L +V+E EE L +K + E E + + L+ + EK+
Sbjct: 924 KIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKE---- 979
Query: 1160 ASRSAAESALKNEGLSSDEEF--DSVYDPSSIASLLTESNLQT 1200
+ E +KN L+ + EF + + + A ++ E++ QT
Sbjct: 980 --KRTTEHKVKN--LTEEVEFLNEDISKLNRAAKVVQEAHQQT 1018
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 173 bits (438), Expect = 1e-42
Identities = 220/973 (22%), Positives = 410/973 (42%), Gaps = 165/973 (16%)
Query: 355 TKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRK 414
T A + ++ ++++LQR+L + +++ K E Q LE +L E E + LQ L R
Sbjct: 1274 TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRR-- 1331
Query: 415 GEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRE 474
A+ E Q + LL ++ L QV LQ + + A +L +DL R
Sbjct: 1332 --AELQRMEAQGERELLQAAKE---NLTAQVEHLQAAVVEARAQASAAGILEEDLRTARS 1386
Query: 475 LL-------EEVLEGKQRVEEQLRLRERELTALK---GALKEEVASRDQEVEHVRQQYQR 524
L E E Q ++EQ L+ + AL+ L + +A R++EVE +R Q Q
Sbjct: 1387 ALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQE 1446
Query: 525 DTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQ-RELEETSEETGHWQSMFQKNKEDLR 583
+Q R MQ A + L+ +++ ++ Q +ELE+ H Q+ ++ L
Sbjct: 1447 LEKQ--REMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLT 1504
Query: 584 ATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRT------ 637
++++ +L ++E L ++ L+++ + + G QV+ LKK+L+
Sbjct: 1505 VQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRG---QVQDLKKQLVTLECLALE 1561
Query: 638 -----------QEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELE------ 680
Q+ +KEL+ +R++Q VA H +LE++ L+ ++ + +LE
Sbjct: 1562 LEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVL 1621
Query: 681 ---------------EQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTL 725
EQ +LQ+ + L QD E + M+ + VL +R L
Sbjct: 1622 ARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKIL 1681
Query: 726 RETQEE---NDEFRRRILGLEQQLKETRGLVDGGEAVEAR---------LRDKLQRLEAE 773
E E+ + R R L ++QL + R G + R LRDK + +E +
Sbjct: 1682 EEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQ 1741
Query: 774 ----------KQQLEEALNASQEEEG--SLAAAKR-----------------------AL 798
K QLE+ L + G SL ++R +L
Sbjct: 1742 QEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSL 1801
Query: 799 EARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKEL 858
+++L+EAQR LA+ QE + L + ++ Q E ++ L+ T+ + EL
Sbjct: 1802 QSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGEL 1861
Query: 859 EKIGEDSK-------------QALQQLQAQLEDYKEKARREVADAQRQAKDWASEAE--- 902
+ E ++ QAL+++ L + + + Q+Q + A E E
Sbjct: 1862 QDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVET 1921
Query: 903 --------KTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKK 954
+ L E++ LR Q+S+ + + AR E L + L + K+
Sbjct: 1922 RALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKE 1981
Query: 955 RSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTD--RVNRGRDQVDQLRTELMQERSA 1012
+ ++A + LE + L+ LD + L + R+ G Q LR +
Sbjct: 1982 QHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQ------- 2034
Query: 1013 RQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQ 1072
+D++ + +L +++++L+ + + +K SL+Q +N + +++ +ERE+ +
Sbjct: 2035 -EDVQQLQQALAQRDEELRHQQEREQLLEK---SLAQRVQENMIQEKQNLGQEREEEEI- 2089
Query: 1073 STNRKLERKVKELSIQIEDERQHVNDQKD-QLSLRVKAL--KRQVDEAEEEIERLDGLRK 1129
R L + V+EL + + + Q + + ++ Q ++AL + EE+ +LD L
Sbjct: 2090 ---RGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEP 2146
Query: 1130 KAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSI 1189
+ QRE+E Q +AR + WR+ ++ A S + + SV +
Sbjct: 2147 RLQRELERLQAALRQTEAR-----EIEWREKAQDLALSLAQTKA--------SVSSLQEV 2193
Query: 1190 ASLLTESNLQTSS 1202
A L S L+ S
Sbjct: 2194 AMFLQASVLERDS 2206
Score = 154 bits (390), Expect = 4e-37
Identities = 206/883 (23%), Positives = 389/883 (44%), Gaps = 130/883 (14%)
Query: 364 LTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKE 423
L V+E ++KL + ++ ++LE + LE + E + +++E ++G+ Q K+
Sbjct: 1492 LPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQ 1551
Query: 424 LQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGK 483
L ++ L + E+ H +E Q Q +K ++G + V L L LEE +
Sbjct: 1552 LVTLECLALELEENHHKMECQ----QKLIKELEGQRETQRVALTHLTLD---LEERSQEL 1604
Query: 484 QRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVL 543
Q Q+ E T L L+E RDQEV+ R+Q E+L+R + TQD L
Sbjct: 1605 QAQSSQIHDLESHSTVLARELQE----RDQEVKSQREQI----EELQRQKEHLTQD---L 1653
Query: 544 EAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEEL 603
E Q++ LQ+E + E+ + + +++L Q+++ E EL
Sbjct: 1654 ERRDQELM-----LQKERIQVLED---------QRTRQTKILEEDLEQIKLSLRERGREL 1699
Query: 604 GEKIEVLQRELEQ----ARASAGDTRQVEVL----KKELLRTQEELKELQA--ERQSQEV 653
+ +++Q E+ ++A G ++++ +KE+ QE + ELQ ++ Q++
Sbjct: 1700 TTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQL 1759
Query: 654 AGRHRD--------RELEKQLAVLRVEADRGRE---LEEQNLQLQ------------KTL 690
G HR + E+++ VL+ + RE L+EQ+LQ Q + L
Sbjct: 1760 QGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQEL 1819
Query: 691 QQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETR 750
+ L+Q+ ++A + + +A L TL+E E + + + LE++L
Sbjct: 1820 EALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVE- 1878
Query: 751 GLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLA----AAKRALEARLEEAQ 806
G V+A L + L L AE ++ E+AL A Q++ A RAL+ +AQ
Sbjct: 1879 -----GRRVQA-LEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQ 1932
Query: 807 RGLARLGQEQQTLNRALEEEGKQREVLRRGKAE-LEE------------QKRLLDRTVDR 853
L QE + L RA + + +E R +AE L+E ++ LL++
Sbjct: 1933 AVLKERDQELEAL-RAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQA--E 1989
Query: 854 LNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQD 913
L++ LE + +L QA +E R + + Q Q + + ++ L++ +
Sbjct: 1990 LSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDE 2049
Query: 914 EIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKK---RSQDDRARQLKGLEEK 970
E++ ++ Q E+ A+ +E + Q Q L QE E ++ Q R QL +++
Sbjct: 2050 ELRHQQEREQL--LEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKE 2107
Query: 971 VSRLETELDEEKNTVELL-----TDRVNRGRDQVDQLRTELMQE----RSARQDLECDKI 1021
LE +++N +E L T + ++D L L +E ++A + E +I
Sbjct: 2108 QEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREI 2167
Query: 1022 SLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQ----ERLQAEEREKTVLQSTNRK 1077
+ +DL LA ++ AS+S L+ LQ ER ++R + L+ T R
Sbjct: 2168 EWREKAQDLALSLAQTK------ASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRA 2221
Query: 1078 LERK---------VKELSIQIED-----ERQHVNDQKDQLSLRVKALKRQVDEAEEEIER 1123
LE++ EL + E E V + + ++ +++++ ++ + R
Sbjct: 2222 LEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVAR 2281
Query: 1124 LDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAE 1166
L+ R + QR + EQ++ + L++++ R A + E
Sbjct: 2282 LEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLE 2324
Score = 149 bits (375), Expect = 2e-35
Identities = 226/965 (23%), Positives = 443/965 (45%), Gaps = 191/965 (19%)
Query: 364 LTRKVEELQRKLDEEVKKRQKLEPSQVGLER-QLEEKTEECSRLQELLERRKGEAQQSNK 422
L K +EL+++ E ++ +L+ SQ LE+ +L+++ E S L ++Q+ N+
Sbjct: 249 LLAKTQELEKEAHERSQELIQLK-SQGDLEKAELQDRVTELSALLT-------QSQKQNE 300
Query: 423 ELQNMKRLLDQGEDLRHGLETQVMELQNKL-KHVQGPEPAKEVLLKDLLETRELLEE--- 478
+ + M + L + ++ T++ME + L ++ Q + + + ++KD+ T+ ++EE
Sbjct: 301 DYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDI--TQVMVEEGDN 358
Query: 479 VLEGK------------------QRVEEQLRLRERELTALKGA---LKEEVASRDQEVEH 517
+ +G Q ++ L L LT + A L++++A + V
Sbjct: 359 IAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNL 418
Query: 518 VRQQYQRDTEQ---LRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSM 574
++QQ+ + E+ LR+ +Q T ER ++ LQ E++ S+E Q
Sbjct: 419 LQQQHDQWEEEGKALRQRLQKLT-------GERDTLAGQTVDLQGEVDSLSKERELLQKA 471
Query: 575 FQKNKEDLRATKQELLQLRM--------------EKEEMEEELGEKIEVLQRELEQARAS 620
++ ++ L +QE +LR +KEE +EEL + V +RE Q
Sbjct: 472 REELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEEL--HLAVRERERLQEMLM 529
Query: 621 AGDTRQVEVLKKELLRTQEELK------ELQAERQSQEVAGRHR-----------DRELE 663
+ +Q E L EL+ +E L+ EL + Q++ A R + L+
Sbjct: 530 GLEAKQSESLS-ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLK 588
Query: 664 KQLAVLRVEADRGRELEE-----------QNLQLQKTLQQLRQDCEEASKAKMVAEAEAT 712
++A LR A + L E Q LQL++ Q + E A +A+ + +
Sbjct: 589 TEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLA 648
Query: 713 VLGQRRAAV-------ETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRD 765
+RR A+ E L++ +E E + + ++++ +E + + +
Sbjct: 649 EAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATT 708
Query: 766 KLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALE- 824
+L++L E ++ EE L + +E+ +L K ALE RL+ +R L ++ Q L+ A E
Sbjct: 709 QLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKEL 768
Query: 825 ------EEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLED 878
E +Q V+ K +LE Q + + + + + E+ + K L ++Q E
Sbjct: 769 LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCL----KLELDTERSQAEQ 824
Query: 879 YKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQA--ERDTAR--- 933
++ A R++A A+++ K A E +K + + E+ +LR+ + ++ +++ A+
Sbjct: 825 ERDAAARQLAQAEQEGKT-ALEQQKAAH-----EKEVNQLREKWEKERSWHQQELAKALE 878
Query: 934 -LDKELLAQRLQGLEQEAE--------NKKRSQDDRA---RQLKGLEEKVSRLETELDEE 981
L++E + ++ EQ+ E ++R+Q + A QL+ +E+VS LET L +
Sbjct: 879 SLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQ 938
Query: 982 KN---------------TVELLTDRVNRG--RDQVDQLRTELMQ-ERSARQDLEC----- 1018
K V+ L ++ G + Q+ + + EL + R R DL
Sbjct: 939 KELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEES 998
Query: 1019 -----DKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQ----ERLQAE-EREK 1068
DK+ L++Q +DLK++L + + Q+ L + E Q +L + R+Q E EREK
Sbjct: 999 SSLLQDKMDLQKQVEDLKSQLVAQDDSQR----LVEQEVQEKLRETQEYNRIQKELEREK 1054
Query: 1069 TVLQSTNRKLERKV-----------KELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEA 1117
L + + E+++ +ELS +D ++ +QK +LS +++ L+++V E
Sbjct: 1055 ASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQK-ELSAQMELLRQEVKEK 1113
Query: 1118 EEEIERLDGLRKKAQ--REVEEQHEVNEQLQARIKSLE-KDSWRKASRSAAESALKNEGL 1174
E D L ++AQ E+E H +QL+A + + E K + + + ES L E L
Sbjct: 1114 E-----ADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQL--EAL 1166
Query: 1175 SSDEE 1179
+++++
Sbjct: 1167 AAEQQ 1171
Score = 145 bits (365), Expect = 3e-34
Identities = 195/810 (24%), Positives = 378/810 (46%), Gaps = 82/810 (10%)
Query: 356 KAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLE--RR 413
K + L + +LQ ++D K+R+ L+ ++ L +QLE +E RL+ + +
Sbjct: 439 KLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQL 498
Query: 414 KGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETR 473
+G++ Q KE Q + L E R L+ +M L+ K Q ++ + L++ LE+
Sbjct: 499 QGDSAQGQKEEQQEELHLAVRE--RERLQEMLMGLEAK----QSESLSELITLREALESS 552
Query: 474 ELLEEVLEGKQ-RVEEQLRLRER---ELTALKGALKEEVA---SRDQEVEHVRQQYQRDT 526
L E+L +Q V L E+ EL++ + LK EVA + ++ + + D
Sbjct: 553 HLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDK 612
Query: 527 EQLRRSMQDATQDH----AVLEAERQKMSALVRGL---QRELEETSEETGHWQSMFQKNK 579
L + + +++ + +EA Q +AL L ++ E E+ H ++ QK +
Sbjct: 613 VGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAE 672
Query: 580 EDLRATKQELLQLRMEKEEMEEELGE---KIEVLQRELEQARASAGDTRQVEVL------ 630
E + +L ++ EKEE++++L E + E +LEQ A RQ EVL
Sbjct: 673 EAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEA--KRQEEVLARAVQE 730
Query: 631 KKELLRTQEELK-ELQA-ERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQK 688
K+ L+R + L+ LQA ER Q++A + + K+L + E ++QN ++
Sbjct: 731 KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSL-----FEAQQQNSVIEV 785
Query: 689 TLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKE 748
T QL + ++AK V + E L + ++T + ++E D R++ EQ+ K
Sbjct: 786 TKGQLEVQIQTVTQAKEVIQGEVRCL---KLELDTERSQAEQERDAAARQLAQAEQEGKT 842
Query: 749 TRGLVDGGEAVEA-RLRDKLQRLEA-EKQQLEEALNASQEEEGSLAAAKRALEARLE--E 804
E +LR+K ++ + +Q+L +AL + + E+ L + + +E +
Sbjct: 843 ALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902
Query: 805 AQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGED 864
AQR R E LE E ++ +L + L+ QK L D +++LE++ +D
Sbjct: 903 AQREEERTQAESALCQMQLETEKERVSLL---ETLLQTQKELAD-----ASQQLERLRQD 954
Query: 865 SKQALQQLQAQ-----LEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLR 919
K +Q+L+ Q L+ ++A+RE+ +A RQ +D + ++ S L + + ++Q+
Sbjct: 955 MK--VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQV 1012
Query: 920 QALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELD 979
+ L++ +D +QRL +EQE + K R + R K LE + + L L
Sbjct: 1013 EDLKSQLVAQDD--------SQRL--VEQEVQEKLRETQEYNRIQKELEREKASLTLSLM 1062
Query: 980 EEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEG 1039
E++ + +L + + + ++ LR ++ + + +++L L ++ K+ + + E
Sbjct: 1063 EKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQE- 1121
Query: 1040 FQKPSASLSQLESQN---QLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHV 1096
+ L +LE+ + Q L+ L A+E + LQ R E +++ L+ + + Q
Sbjct: 1122 ----AQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQ-- 1175
Query: 1097 NDQKDQLSLRVKALKRQVDEAEEEIERLDG 1126
+ QL+ AL++ + E L G
Sbjct: 1176 AQAQAQLASLYSALQQALGSVCESRPELSG 1205
Score = 125 bits (314), Expect = 2e-28
Identities = 172/842 (20%), Positives = 367/842 (43%), Gaps = 106/842 (12%)
Query: 401 EECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLR-------HGLETQVMELQNKLK 453
++ +L+E L + E Q + ELQ+++R L Q ++ + + LE+++MEL +
Sbjct: 1264 DQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMA 1323
Query: 454 HVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLR---LRERELTALKGALKEEVAS 510
+Q E+ + RELL+ E E L+ + R + G L+E++ +
Sbjct: 1324 SLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRT 1383
Query: 511 RDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGH 570
++ ++ + + E+ + + A +A ++ ++ L + L EE G
Sbjct: 1384 ARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQ 1443
Query: 571 WQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQ-VEV 629
Q + + + +++ ELL L ++K E +L + E +Q ELE+ R+ V+
Sbjct: 1444 IQEL--EKQREMQKAALELLSLDLKKRNQEVDLQQ--EQIQ-ELEKCRSVLEHLPMAVQE 1498
Query: 630 LKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKT 689
+++L +E+++EL+ +R++Q H+ ELEK+ ++ + + ++L++Q + L+
Sbjct: 1499 REQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECL 1558
Query: 690 LQQLRQDCEEAS-KAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKE 748
+L ++ + + K++ E E QR A TL + +E + E L+ Q +
Sbjct: 1559 ALELEENHHKMECQQKLIKELEGQRETQRVALTHLTL-DLEERSQE-------LQAQSSQ 1610
Query: 749 TRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRG 808
L + L+++ Q ++++++Q+EE L+ + E +
Sbjct: 1611 IHDLESHSTVLARELQERDQEVKSQREQIEE------------------LQRQKEHLTQD 1652
Query: 809 LARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQA 868
L R QE Q+E ++ + + Q ++L+ ++++ L + G +
Sbjct: 1653 LERRDQELML----------QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQ 1702
Query: 869 LQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAE 928
Q +Q + E+ K ++ AQR G L ++ ++ + ++ Q
Sbjct: 1703 RQLMQERAEEGKGPSK-----AQR-------------GSLEHMKLILRDKEKEVECQQEH 1744
Query: 929 RDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELL 988
+ K+ L Q+LQGL ++ R +++ L++++ + + ++ +++
Sbjct: 1745 IHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQ 1804
Query: 989 TDRVNRGRDQVDQLRTELMQERSARQDLE------CDKI--SLERQNKDLKTRLASSEGF 1040
D R Q DQ L QE+ Q E D + +LE+ + LK R +
Sbjct: 1805 LDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDH 1864
Query: 1041 QKPSASLSQ---LESQN-QLLQE-----RLQAEEREKTVL----QSTNRKLERKVKELSI 1087
++ + L + +E + Q L+E R ++ E+EK +L Q + E +V+ ++
Sbjct: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRAL 1924
Query: 1088 QIE-DERQHVNDQKDQ----LSLRVKALKRQVDEAEEEIERLDGLRKKA-------QREV 1135
Q + Q V ++DQ L ++ + Q + A E L KA ++ +
Sbjct: 1925 QDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHL 1984
Query: 1136 EEQHEVNEQLQARIKSLEK--DSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLL 1193
EQ E++ L+A +L+ D+ + SR E+ EG D++ D + L
Sbjct: 1985 LEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQAL 2044
Query: 1194 TE 1195
+
Sbjct: 2045 AQ 2046
Score = 123 bits (309), Expect = 9e-28
Identities = 185/864 (21%), Positives = 359/864 (41%), Gaps = 105/864 (12%)
Query: 384 KLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLET 443
K + Q+ LE Q+ ++ + Q R+ +Q++ + + R L Q + L++ +
Sbjct: 12 KPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKL-QAKVLQY--RS 68
Query: 444 QVMELQNKLKHVQGPEPAK-----EVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELT 498
EL+ +L+ GP P + E L +LL E ++ E V QLRL +
Sbjct: 69 WCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKAD 128
Query: 499 ALKGALKEEVASRDQEVEHVRQQYQRDTEQ----------------------------LR 530
+ AL+E+V + R + R Q R
Sbjct: 129 VVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFR 188
Query: 531 R---SMQDAT-QDHAVLEAERQKMSA--LVRGLQRELEETSEETGHWQSMFQKNKEDLRA 584
R M+ AT +D L+AE ++S L L+ + S E + D R
Sbjct: 189 RHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPN------GSGRMDGRE 242
Query: 585 TKQELLQLRMEKEEMEEELGEKIEVL-----QRELEQARASAGDTRQVEVLKKELLRTQE 639
Q LL L + +E+E+E E+ + L Q +LE+A T +L + + ++
Sbjct: 243 PAQ-LLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNED 301
Query: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQ---- 695
K ++A R++ E+ + +E EA R +E+ L LQ+ ++ + Q
Sbjct: 302 YEKMIKALRETVEILETNHTELMEH-------EASLSRNAQEEKLSLQQVIKDITQVMVE 354
Query: 696 ---DCEEASKAKMVAEAEATVLGQ--------RRAAVETTLRETQEENDEFRRRILGLEQ 744
+ + S + E ++++ Q V + L ++ + R+++ G ++
Sbjct: 355 EGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQE 414
Query: 745 QLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEE 804
+ + D E LR +LQ+L E+ L Q E SL+ + L+ EE
Sbjct: 415 AVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREE 474
Query: 805 AQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGED 864
++ L L QE L R E Q + + K E +E+ L R +RL + L +
Sbjct: 475 LRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAK 534
Query: 865 SKQALQQLQAQLEDYKEKARRE---VADAQRQAKDWASEAEKTSGGLS----RLQDEIQR 917
++L +L L + E + E + Q + + AE++ LS L+ E+
Sbjct: 535 QSESLSEL-ITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVAD 593
Query: 918 LRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETE 977
LR A A + LDK L Q+L LE+E ++ +++ E+ + L+ +
Sbjct: 594 LRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSV-------CSRMEAAEQARNALQVD 646
Query: 978 LDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASS 1037
L E + E L ++ L +L + A +L+ D ++ + ++++ +L+ S
Sbjct: 647 LAEAEKRREALWEKNT-------HLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSES 699
Query: 1038 EGFQKPSAS-LSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHV 1096
Q+ + + L QL + + +E L +EK L LE +++ +E +RQ +
Sbjct: 700 RHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQ----AVERDRQDL 755
Query: 1097 NDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIK--SLEK 1154
+Q LS + L+ + EA+++ ++ + + + +++ + E +Q ++ LE
Sbjct: 756 AEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL 815
Query: 1155 DSWRKASRSAAESALKNEGLSSDE 1178
D+ R + ++A + + E
Sbjct: 816 DTERSQAEQERDAAARQLAQAEQE 839
Score = 122 bits (305), Expect = 3e-27
Identities = 181/794 (22%), Positives = 333/794 (41%), Gaps = 153/794 (19%)
Query: 367 KVEELQRK---LDEEVKKR-QKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 422
++EELQR+ L +++++R Q+L + ++ +++T + L+E LE+ K ++ +
Sbjct: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGR 1697
Query: 423 ELQNMKRLLDQGED--------LRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRE 474
EL ++L+ + + R LE + L++K K V+ ++ + +L E ++
Sbjct: 1698 ELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE----CQQEHIHELQELKD 1753
Query: 475 LLEEVLEGKQRVEEQLRL----RERELTALK---------GALKEE------------VA 509
LE+ L+G R + L RE+E+ L+ G LKE+ +A
Sbjct: 1754 QLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALA 1813
Query: 510 SRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQ------RELEE 563
RDQE+E ++Q+ Q+ Q R + A LE + LQ R LEE
Sbjct: 1814 QRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEE 1873
Query: 564 TSEETGHWQSMFQKNKEDLRATKQE----LLQLRMEKEEMEEELGEKIEVLQ-------- 611
G ++ DLRA +E LL L+ + E +E + LQ
Sbjct: 1874 ELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQA 1933
Query: 612 ------RELEQARASAGDTR-QVEVLKKELLRTQEELKELQAERQSQE---VAGRHRDRE 661
+ELE RA + +R Q E + QE L + A Q +E + R
Sbjct: 1934 VLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRS 1993
Query: 662 LEKQLAVLRVEAD----RGRELEE----QNLQLQKTLQQLRQDCEEASKAKMVAEAEATV 713
LE A L+ D R+LEE Q ++Q + ++D ++ +A + E
Sbjct: 1994 LEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRH 2053
Query: 714 LGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAE 773
+R +E +L + +EN ++ LG E++ +E RGL ++ L K Q +
Sbjct: 2054 QQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEI--- 2110
Query: 774 KQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVL 833
LE R + + L L +T
Sbjct: 2111 ------------------------LELRETQQRNNLEALPHSHKT--------------- 2131
Query: 834 RRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKA---------- 883
+ +EEQ LD RL +ELE++ + AL+Q +A+ +++EKA
Sbjct: 2132 ----SPMEEQSLKLDSLEPRLQRELERL----QAALRQTEAREIEWREKAQDLALSLAQT 2183
Query: 884 RREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRL 943
+ V+ Q A + + RLQDE++ R+AL+ + A EL ++
Sbjct: 2184 KASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGE 2243
Query: 944 QGLE------QEAENKKRSQDDRA--RQLKGLEEKVSRLETELDE-EKNTVELLTDRVNR 994
QG++ EAE + ++ ++L+ L++ V+RLE + +++ V+L +
Sbjct: 2244 QGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRST---- 2299
Query: 995 GRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQN 1054
+QV++ R +L +R A + + + + + T+ + +++L+ +
Sbjct: 2300 -LEQVERERRKL--KREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEV 2356
Query: 1055 QLLQERLQAEEREK 1068
LLQ +L E ++K
Sbjct: 2357 VLLQAQLTLERKQK 2370
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 171 bits (434), Expect = 3e-42
Identities = 197/860 (22%), Positives = 373/860 (43%), Gaps = 91/860 (10%)
Query: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 422
EL ++EEL+ +++ E R K+E + L R+LEE +E RL+E + + + K
Sbjct: 1114 ELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISE---RLEEASGATSAQIEMNKK 1170
Query: 423 ---ELQNMKRLLDQGE--------DLRHGLETQVMELQNKLKHVQGP----EPAKEVLLK 467
E Q M+R L++ LR V EL ++ ++Q E K L
Sbjct: 1171 REAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKM 1230
Query: 468 DLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTE 527
++ + +E + + K +E R E + + +K A E+ ++ + + Q
Sbjct: 1231 EIDDMASNIEALSKSKSNIERTCRTVEDQFSEIK-AKDEQQTQLIHDLNMQKARLQTQNG 1289
Query: 528 QLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQ 587
+L +++ + L +Q ++ + L+R++EE ++ Q ++ D ++
Sbjct: 1290 ELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLRE 1349
Query: 588 ELLQLRMEKEEMEEELGE-KIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKE--- 643
+ + + K E++ L + EV Q + + T ++E KK+L + +E +E
Sbjct: 1350 QYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTE 1409
Query: 644 ------LQAERQSQEVAGRHRD--RELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQ 695
E+ Q + G D R+LE+ + R ++ + ++ L + +
Sbjct: 1410 TANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQA 1469
Query: 696 DCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDG 755
+ E A K E + V L + EN + I L +Q+ ET G
Sbjct: 1470 ELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAET-----G 1524
Query: 756 GEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAK-RALEARLEEAQRGLARLGQ 814
EA KL +E EK L+ AL +E EGSL + + L +LE L Q
Sbjct: 1525 KNLQEAEKTKKL--VEQEKSDLQVAL---EEVEGSLEHEESKILRVQLE--------LSQ 1571
Query: 815 EQQTLNRALEEEGKQREVLRRGKAELEEQ-KRLLDRTVD------RLNKELE-------- 859
+ L+R + E+ ++ E L+R E + +LD + RL K++E
Sbjct: 1572 VKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEI 1631
Query: 860 KIGEDSKQA------LQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQD 913
++G ++Q L+ +Q QL+D ++ + DA R +D + L +
Sbjct: 1632 QLGHSNRQMAETQKHLRTVQGQLKD----SQLHLDDALRSNEDLKEQLAIVERRNGLLLE 1687
Query: 914 EIQRLRQALQASQAERDTARLDKELL--AQRLQGLEQEAENKKRSQDDRARQLKGLEEKV 971
E++ ++ AL+ Q ER ++ELL + R+Q L + + ++ K LE +
Sbjct: 1688 ELEEMKVALE--QTERTRRLSEQELLDASDRVQLLHSQNTSLINTK-------KKLEADI 1738
Query: 972 SRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLK 1031
++ + E++ ++ + + EL +E+ LE K +LE+ KDL+
Sbjct: 1739 AQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQ 1798
Query: 1032 TRLASSE--GFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQI 1089
RL +E + + +LE++ + L+ L E++ K ERKVKE++ Q
Sbjct: 1799 HRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQA 1858
Query: 1090 EDERQHV---NDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQ 1146
E++ +++ D D+L +VK+ KRQ +EAEE+ ++ Q E+EE E + +
Sbjct: 1859 EEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAE 1918
Query: 1147 ARIKSLEKDSWRKASRSAAE 1166
+++ L S S+ E
Sbjct: 1919 SQVNKLRAKSRDVGSQKMEE 1938
Score = 156 bits (394), Expect = 1e-37
Identities = 199/907 (21%), Positives = 398/907 (43%), Gaps = 104/907 (11%)
Query: 290 LQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVM 349
L FK P L + E + + T + R + E + VSL+ EK +
Sbjct: 836 LFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELE-EKMVSLLQEKNDLQLQ 894
Query: 350 VSSGSTKAVAGQGE----------LTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEK 399
V S + + + L KV+EL +L+EE + +L V +R LE+K
Sbjct: 895 VQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSEL----VAKKRNLEDK 950
Query: 400 TEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPE 459
R + LE + ++ +N + L + LE + +L + K +Q
Sbjct: 951 CSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMT---ALEENISKLTKEKKSLQ--- 1004
Query: 460 PAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVR 519
A + L DL ++ E+ + G ++ +L E++ L+G+L++E R ++E +
Sbjct: 1005 EAHQQTLDDL----QVEEDKVNGLIKINAKL---EQQTDDLEGSLEQEKKLR-ADLERAK 1056
Query: 520 QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNK 579
++ + D + + S+ D D +E + +K + LQ ++++ + FQK
Sbjct: 1057 RKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHS----LQFQKKI 1112
Query: 580 EDLRATKQELLQ-------LRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKK 632
++L+A +EL + LR + E+ +L ++E + LE+A S + Q+E+ KK
Sbjct: 1113 KELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEA--SGATSAQIEMNKK 1170
Query: 633 ELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRV-EADRGRELEEQNLQLQKTLQ 691
Q+ ++L+ E +H E A LR +AD EL EQ LQ+ Q
Sbjct: 1171 REAEFQKMRRDLE------EATLQH-----EATAATLRKKQADSVAELGEQIDNLQRVKQ 1219
Query: 692 QLRQDCEEASKAKMVAEAEAT---VLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKE 748
+L + E S+ KM + A+ L + ++ +E T R +++ E + + EQQ
Sbjct: 1220 KLEK---EKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKD---EQQ--- 1270
Query: 749 TRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRG 808
T+ + D L + RL+ + +L + + L +K+AL +LEE +R
Sbjct: 1271 TQLIHD--------LNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQ 1322
Query: 809 LARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQA 868
+ + + + AL+ ++LR E +E K L R + + N E+ + +
Sbjct: 1323 MEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETD 1382
Query: 869 LQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAE 928
Q +LE+ K+K + + +A+ + S+ RLQ E++ L + L+ S
Sbjct: 1383 AIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA 1442
Query: 929 RDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELL 988
A LDK + + ++ K+ D+ +L+ +++ L TEL + +N E +
Sbjct: 1443 --CATLDK-----KQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEV 1495
Query: 989 TDRVNRGR-------DQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQ 1041
D++ R +++ L ++ + Q+ E K +E++ DL+ L EG
Sbjct: 1496 VDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSL 1555
Query: 1042 KPSAS--------LSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDER 1093
+ S LSQ++S +L ++ ++ +E + + +++ R E L +I
Sbjct: 1556 EHEESKILRVQLELSQVKS--ELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRN 1613
Query: 1094 QHVNDQK------DQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQA 1147
+ +K +++ +++ RQ+ E ++ + + G K +Q +++ NE L+
Sbjct: 1614 DALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKE 1673
Query: 1148 RIKSLEK 1154
++ +E+
Sbjct: 1674 QLAIVER 1680
Score = 50.8 bits (120), Expect = 8e-06
Identities = 43/181 (23%), Positives = 90/181 (49%), Gaps = 11/181 (6%)
Query: 1006 LMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQL-----LQER 1060
L++ A +++ K ER ++L A + ++ SL Q ++ QL +
Sbjct: 843 LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENL 902
Query: 1061 LQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVND---QKDQLSLRVKALKRQVDEA 1117
+ AEER + +++S LE KVKEL+ ++E+E + ++ +K L + +LKR +D+
Sbjct: 903 MDAEERCEGLIKS-KILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDL 961
Query: 1118 EEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSD 1177
E + +++ + + +V+ E L+ I L K+ +K+ + A + L + + D
Sbjct: 962 ELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKE--KKSLQEAHQQTLDDLQVEED 1019
Query: 1178 E 1178
+
Sbjct: 1020 K 1020
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 164 bits (416), Expect = 4e-40
Identities = 232/974 (23%), Positives = 425/974 (43%), Gaps = 131/974 (13%)
Query: 258 SPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLL--RDQQEAAPPGSVDHMK 315
SP+ ++ Q Q L+ RS +D L+ LL +D Q A +D +
Sbjct: 203 SPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRL- 261
Query: 316 ATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAG----QGELTRKVEEL 371
+L E + S + L +K + L M + K + ++ RK+ +L
Sbjct: 262 ----ALLNEKQAASPLEPKELEEL-RDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQL 316
Query: 372 QRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRL-QELLERRKGEAQQSNKELQNMKRL 430
+ + K ++ L+ L E TEE S+ QE LE++ ++ + LQ+ K L
Sbjct: 317 SEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCL 376
Query: 431 LDQGEDLRHGLETQVMELQNKLKHVQ-GPEPAKEVLLKDLLETRELLEE----------- 478
++ E L+ L +L+ L +Q P K +L D+L+ L +E
Sbjct: 377 EEKNEILQGKLS----QLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQL 432
Query: 479 -----VLEGKQRVEEQLRLRER--------ELTALKGALKEEVASRDQEVEHVRQQYQRD 525
+LE ++ +E L ER +L++L L+ +++ Q E + Q Q
Sbjct: 433 QARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAH 492
Query: 526 TEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRAT 585
+L + T + L A Q+ + GL+++ +E + ++ + LR
Sbjct: 493 GARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQ 552
Query: 586 KQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQ------E 639
++L +KE+ +E+ EK E +++ Q A+A + R+ + +++ Q E
Sbjct: 553 VEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE 612
Query: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE 699
+ +L+ +Q +VA RD R +A+ R++EE LQ ++ RQ+ E
Sbjct: 613 KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEE----LQACVETARQEQHE 668
Query: 700 ASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAV 759
A VAE E + +++ A E +E D+ + ++ L++ LK T+G ++ +
Sbjct: 669 AQ--AQVAELELQLRSEQQKATEK--ERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRR 724
Query: 760 EARLRDKLQR----LEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQE 815
A ++ QR L+AE + L E ++E A ++ LEARL++ LG+
Sbjct: 725 AADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQ-------LGEA 777
Query: 816 QQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKEL---EKIGEDSKQALQQL 872
Q + EVLRR AE + + ++L KE+ + EDS+Q Q
Sbjct: 778 HQA----------ETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQY 827
Query: 873 QAQ-------LEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLR----QA 921
A L++ EKAR+E+ +A+ + S +E +SR Q+E+ L +A
Sbjct: 828 GAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQ---ISRQQNELAELHANLARA 884
Query: 922 LQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEE 981
LQ Q +KE+ AQ+L A++ Q+ A K +V+RLET + +
Sbjct: 885 LQQVQ--------EKEVRAQKL------ADDLSTLQEKMAATSK----EVARLETLVRKA 926
Query: 982 KNTVELLTDRVNRGRDQVDQLRTELMQERSARQ--DLECDKISLERQNKDLKTRLASSEG 1039
E + + + + + E ++E+ RQ + ++ER+ + + L
Sbjct: 927 GEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL----- 981
Query: 1040 FQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDE---RQHV 1096
++ A+L +ESQ Q +ER Q E + Q R E + + E E + +
Sbjct: 982 -ERLRAAL--MESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1038
Query: 1097 NDQKDQLSLRVKALKRQVDEAE---EEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLE 1153
N+Q+ + + +AL + E E +E+ +L GL +E+EE + +QL+ ++ E
Sbjct: 1039 NEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKE 1098
Query: 1154 KDSWRKASRSAAES 1167
K+ AS S A+S
Sbjct: 1099 KE---HASGSGAQS 1109
Score = 153 bits (387), Expect = 8e-37
Identities = 219/966 (22%), Positives = 409/966 (42%), Gaps = 168/966 (17%)
Query: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 422
E K +L+++L ++ ++ LE L+ +L + E S+LQ+ + KGE
Sbjct: 354 EWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVL 413
Query: 423 ELQNMKR----LLDQGEDLR---HGLETQVMELQNKLKHVQGP-EPAKEVLLKDLLETRE 474
+L+ +K+ L L+ LET+ + + KL +G E K+ L + + +
Sbjct: 414 QLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQS 473
Query: 475 LLEEVLEGKQRVEEQLRLRERELTALKGALKEEVAS-------RDQEVEHVRQQYQRDTE 527
+ + + K+ +E+ + LTA +L E+ + +DQE+ ++QQ +
Sbjct: 474 SISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQA 533
Query: 528 QLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEET-----GHWQSMF---QKNK 579
QL +++Q Q L + +++S+ ++ +++L+E +E+ H Q + ++ +
Sbjct: 534 QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEERE 593
Query: 580 EDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVL-----KKEL 634
LR L QL E +E+E K+E+LQ++L+ A A D+ Q V K EL
Sbjct: 594 ASLRERDAALKQL----EALEKEKAAKLEILQQQLQVAN-EARDSAQTSVTQAQREKAEL 648
Query: 635 LRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLR 694
R EEL+ + ++ + + ELE QL + +A + ++ QLQ+ LQ L+
Sbjct: 649 SRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALK 708
Query: 695 QDCEEASKAKMVAEAE--ATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGL 752
+ + +K + E A L +++ + ET+ ++ +R LE++ +GL
Sbjct: 709 ESLK-VTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGL 767
Query: 753 VDGGEAVEARLRDKLQRLEAE----KQQLEEALNASQEEEGS---LAAAKRALEARLEEA 805
EARL+ + +AE +++L EA+ A E L A R E++
Sbjct: 768 -------EARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDS 820
Query: 806 QRGLARLGQEQQTLNRALEEE-GKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGED 864
Q+ A+ G Q L+EE K R+ L+ K ++ + + + R EL ++ +
Sbjct: 821 QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHAN 880
Query: 865 SKQALQQLQ---------------------------AQLE-------DYKEKARREVADA 890
+ALQQ+Q A+LE + +E A RE+
Sbjct: 881 LARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKE 940
Query: 891 QRQAKD----WASEAE-----KTSGGLSRLQ-------DEIQRLRQALQASQAERDTARL 934
+A D W E + T L ++ +E++RLR AL SQ ++ R
Sbjct: 941 PARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERG 1000
Query: 935 DKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNR 994
+E RL + + R+Q D A + E RL+ L+E++ L + +
Sbjct: 1001 QQEREVARL------TQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAH 1054
Query: 995 GRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE--------------GF 1040
+ + EL + R + L + K LK +LA E G
Sbjct: 1055 ALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGR 1114
Query: 1041 QKPS--------ASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDE 1092
+P+ A +S+LE Q Q QE+ + ER +++ + + ++ L Q+E++
Sbjct: 1115 TEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEK 1174
Query: 1093 RQHVNDQKDQLSLRVKAL-----------------KRQVDEAEEEIER------------ 1123
Q + + L+ + L K QV +E ER
Sbjct: 1175 AQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEV 1234
Query: 1124 ---------LDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSA-AESALKNEG 1173
+G K+ +R V + E +++L+ R++ L+ ++ ++R+A SAL+ E
Sbjct: 1235 SILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEV 1294
Query: 1174 LSSDEE 1179
S EE
Sbjct: 1295 QSLREE 1300
Score = 141 bits (356), Expect = 3e-33
Identities = 185/804 (23%), Positives = 355/804 (44%), Gaps = 108/804 (13%)
Query: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 422
++ ++E L+ L E ++Q+ Q ER++ T+E R Q L K +
Sbjct: 976 QMGNELERLRAALMESQGQQQEERGQQ---EREVARLTQERGRAQADLALEKAARAELEM 1032
Query: 423 ELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDL--LETREL--LEE 478
LQN L +Q + LQ L H + K+ L L LE ++ LEE
Sbjct: 1033 RLQNA--LNEQ--------RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEE 1082
Query: 479 VLEGKQRVEEQLRLRERELTALKGALKEEVASRDQ----EVEHVRQQYQRDTEQLRRSMQ 534
+ + ++++EQL +E+E + GA + E A R + ++E +R + + +Q ++ +
Sbjct: 1083 LRQTVKQLKEQLAKKEKEHASGSGA-QSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQE 1141
Query: 535 DATQDHAVLEAERQKMS---ALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQ 591
A LEAER + + + LQ +LEE ++E GH QS + +L A + ++
Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKV-- 1199
Query: 592 LRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQ-VEVLKKELLRTQEELKELQAERQS 650
+ + E+E ++ ++E E+ + + V +L +++L + E KEL+
Sbjct: 1200 --QDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKR---- 1253
Query: 651 QEVAGRHRDRELEKQLAVLRVE-ADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEA 709
+A + ++LE++L +L+ E A E++ L++ +Q LR++ E+ A
Sbjct: 1254 LVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQ 1313
Query: 710 EATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQR 769
E T +R + L+ QE+ + + + L+ + T+ LV E + A+ Q+
Sbjct: 1314 ELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVS--ELLPAK--HLCQQ 1369
Query: 770 LEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQ 829
L+AE+ E+ E+ A L A L AQR L L L + + E+ +
Sbjct: 1370 LQAEQAAAEKRHREELEQSKQAAGG---LRAELLRAQRELGEL----IPLRQKVAEQERT 1422
Query: 830 REVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVAD 889
+ LR KA EQ +L + L +E +GE + Q L+ +L+ +EK +E+A
Sbjct: 1423 AQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAA 1482
Query: 890 AQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQE 949
+ A+ L+ +Q E Q + L+ A+ + A++ +
Sbjct: 1483 VRADAET----------RLAEVQREAQSTARELEVMTAKYEGAKV-------------KV 1519
Query: 950 AENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQE 1009
E ++R Q++R + L +V +LE E+ VE L+ ++ DQ +++ + ++
Sbjct: 1520 LEERQRFQEERQK----LTAQVEQLEVFQREQTKQVEELSKKL-ADSDQASKVQQQKLKA 1574
Query: 1010 RSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKT 1069
A+ S + Q+ A L++L++Q L ++ QA E K
Sbjct: 1575 VQAQGG-------------------ESQQEAQRLQAQLNELQAQ---LSQKEQAAEHYKL 1612
Query: 1070 VLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRK 1129
++ + K + + Q + +Q L + L+++ E E ERL +
Sbjct: 1613 QMEKAKTHYDAK--------KQQNQELQEQLRSL----EQLQKENKELRAEAERLGHELQ 1660
Query: 1130 KAQREVEEQHEVNEQLQARIKSLE 1153
+A + +E + L A+++SLE
Sbjct: 1661 QAGLKTKEAEQTCRHLTAQVRSLE 1684
Score = 128 bits (321), Expect = 4e-29
Identities = 195/876 (22%), Positives = 365/876 (41%), Gaps = 97/876 (11%)
Query: 361 QGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQS 420
Q +L EE ++ E + ++K+ + E Q+ + E + L L R + Q+
Sbjct: 832 QEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEK 891
Query: 421 NKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHV-QGPEPAKEVLLKDLLETRELLEEV 479
Q + L ++ +V L+ ++ + E A L+K+ + E
Sbjct: 892 EVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEW 951
Query: 480 LEGKQ------------RVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTE 527
LE +Q +E + EL L+ AL E + +E R Q +R+
Sbjct: 952 LEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEE----RGQQEREVA 1007
Query: 528 QLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQ 587
+L + A D A+ +A R ++ LQ L E E Q + Q
Sbjct: 1008 RLTQERGRAQADLALEKAARAELEMR---LQNALNEQRVEFATLQEALAHALTEKEGKDQ 1064
Query: 588 ELLQLR-------MEKEEMEEELGE-KIEVLQRELEQARAS------AGDTR-------- 625
EL +LR E EE+ + + + K ++ ++E E A S AG T
Sbjct: 1065 ELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEA 1124
Query: 626 ---QVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQ 682
+V L+++ + QE+ L+ +++ + RD LE L +A +
Sbjct: 1125 LRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSA 1184
Query: 683 NLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGL 742
Q+ L R ++ SKA+ +A+ Q + + +EE R++L
Sbjct: 1185 LASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEK 1244
Query: 743 EQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARL 802
E + KE + LV +L ++L+ L+A E A N+++ E S +A + +++
Sbjct: 1245 EGESKELKRLVMAESEKSQKLEERLRLLQA-----ETASNSARAAERS-SALREEVQSLR 1298
Query: 803 EEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIG 862
EEA++ R+ E L + L + ++ E L + +E+ ++ + L E
Sbjct: 1299 EEAEK--QRVASE--NLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLE----- 1349
Query: 863 EDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGL-------SRLQDEI 915
S QAL + ++ + E A A+++ ++ ++++ +GGL R E+
Sbjct: 1350 HTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGEL 1409
Query: 916 QRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSR-- 973
LRQ + + R +K A++L L K++ A + +GL E+ +
Sbjct: 1410 IPLRQKVAEQERTAQQLRAEKASYAEQLSML-------KKAHGLLAEENRGLGERANLGR 1462
Query: 974 --LETELDE--EKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLE-RQNK 1028
LE ELD+ EK EL R D +L + +S ++LE E + K
Sbjct: 1463 QFLEVELDQAREKYVQELAAVRA----DAETRLAEVQREAQSTARELEVMTAKYEGAKVK 1518
Query: 1029 DLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQS--TNRKLERKVKELS 1086
L+ R E QK +A + QLE + ++ Q EE K + S ++ ++K+K +
Sbjct: 1519 VLEERQRFQEERQKLTAQVEQLEVFQR--EQTKQVEELSKKLADSDQASKVQQQKLKAVQ 1576
Query: 1087 IQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQ 1146
Q + +Q + +L ++ L+ Q+ + E+ E +KA+ + + + N++LQ
Sbjct: 1577 AQGGESQQ----EAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQ 1632
Query: 1147 ARIKSLEK-DSWRKASRSAAE---SALKNEGLSSDE 1178
+++SLE+ K R+ AE L+ GL + E
Sbjct: 1633 EQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKE 1668
Score = 105 bits (261), Expect = 3e-22
Identities = 152/640 (23%), Positives = 271/640 (42%), Gaps = 110/640 (17%)
Query: 367 KVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQN 426
+ + L+R L+ E R + + + L+ QLEEK +E Q L + E ++Q+
Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQD 1201
Query: 427 MKRLLDQGE-DLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLE----TRELLEEVL- 480
+ D+ + + G + E + K + E +L + +LE ++EL V+
Sbjct: 1202 HSKAEDEWKAQVARGRQ----EAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMA 1257
Query: 481 --EGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQ 538
E Q++EE+LRL + E + E ++ +EV+ +R++ ++ Q+ T
Sbjct: 1258 ESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTS 1317
Query: 539 DHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDL----------RATKQE 588
+AER EE +E WQ F + ++ L +A E
Sbjct: 1318 -----QAERA-------------EELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSE 1359
Query: 589 LLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKEL---- 644
LL + ++++ E + + ELEQ++ +AG L+ ELLR Q EL EL
Sbjct: 1360 LLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGG------LRAELLRAQRELGELIPLR 1413
Query: 645 ----QAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCE-- 698
+ ER +Q++ R +QL++L+ L E+N L + RQ E
Sbjct: 1414 QKVAEQERTAQQL--RAEKASYAEQLSMLKKAHGL---LAEENRGLGERANLGRQFLEVE 1468
Query: 699 -EASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGE 757
+ ++ K V E A RA ET L E Q E + +E + E
Sbjct: 1469 LDQAREKYVQELAAV-----RADAETRLAEVQRE----------AQSTARELEVMTAKYE 1513
Query: 758 AVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQ--- 814
+ ++ ++ QR + E+Q+L +Q E+ L +R ++EE + LA Q
Sbjct: 1514 GAKVKVLEERQRFQEERQKL-----TAQVEQ--LEVFQREQTKQVEELSKKLADSDQASK 1566
Query: 815 -EQQTLNRALEEEGKQREVLRRGKAELEEQKRLL---DRTVDRLNKELEKIG---EDSKQ 867
+QQ L + G+ ++ +R +A+L E + L ++ + ++EK + KQ
Sbjct: 1567 VQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQ 1626
Query: 868 ALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEK-----TSGGLSRLQDEIQRLRQAL 922
Q+LQ QL R + Q++ K+ +EAE+ GL + E
Sbjct: 1627 QNQELQEQL--------RSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTA 1678
Query: 923 QASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRAR 962
Q E A D++L R G Q A + +S++ +A+
Sbjct: 1679 QVRSLEAQVAHADQQL---RDLGKFQVATDALKSREPQAK 1715
Score = 90.5 bits (223), Expect = 9e-18
Identities = 122/534 (22%), Positives = 223/534 (41%), Gaps = 55/534 (10%)
Query: 660 RELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEA-TVLGQRR 718
R L+KQLA R D ELE + + +K L + ++A A M + +L +++
Sbjct: 217 RRLKKQLADERSNRD---ELELELAENRKLLTE-----KDAQIAMMQQRIDRLALLNEKQ 268
Query: 719 AAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLE 778
AA +E +E D+ + L + LK+ Q L+ EK Q++
Sbjct: 269 AASPLEPKELEELRDKNESLTMRLHETLKQC------------------QDLKTEKSQMD 310
Query: 779 EALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKA 838
+N EE G L+ R + L++ Q L L +E + E KQ ++ + A
Sbjct: 311 RKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLE--KQAQLEKELSA 368
Query: 839 ELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWA 898
L+++K L +E +I + L++ +QL+D + + EV Q +
Sbjct: 369 ALQDKKCL---------EEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLK 419
Query: 899 SEAEKTSGGLSRLQDEIQRLRQALQASQA----ERDTARLDKELLAQRLQGLEQEAENKK 954
EA + ++LQ ++ L +A ER +K+ L+ + L+ N
Sbjct: 420 QEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLS 479
Query: 955 RSQDD--RARQLKG--LEEKVSRLETELDEEKNTVEL----LTDRVNRGRDQVDQLRTEL 1006
+++++ +A Q G L +V+ L +EL T++ L + +++ QL L
Sbjct: 480 QAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTL 539
Query: 1007 MQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEER 1066
Q+ A Q L L K + +L E +K A+ Q E +A R
Sbjct: 540 QQQEQASQGLRHQVEQLSSSLKQKEQQL--KEVAEKQEATRQDHAQQLATAAEEREASLR 597
Query: 1067 EKTVLQSTNRKLER-KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLD 1125
E+ LE+ K +L I ++ + Q N+ +D V +R+ E ++E L
Sbjct: 598 ERDAALKQLEALEKEKAAKLEI-LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQ 656
Query: 1126 GLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEE 1179
+ A++E E +L+ +++S ++ + K R A E E L + +E
Sbjct: 657 ACVETARQEQHEAQAQVAELELQLRSEQQKATEK-ERVAQEKDQLQEQLQALKE 709
Score = 63.2 bits (152), Expect = 1e-09
Identities = 111/509 (21%), Positives = 199/509 (39%), Gaps = 97/509 (19%)
Query: 362 GELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKT---EECSRLQE----LLERRK 414
G L ++ QR+L E + RQK+ + ++ EK E+ S L++ L E +
Sbjct: 1393 GGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENR 1452
Query: 415 GEAQQSNKELQNMKRLLDQGED--------LRHGLETQVMELQNKL----KHVQGPEPAK 462
G +++N Q ++ LDQ + +R ET++ E+Q + + ++
Sbjct: 1453 GLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKY 1512
Query: 463 EVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQY 522
E +LE R+ +E + EQL + +RE T L +++A DQ + +Q+
Sbjct: 1513 EGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKL 1572
Query: 523 QRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDL 582
+ Q S Q+A Q++ A + LQ +L + + H++ +K K
Sbjct: 1573 KAVQAQGGESQQEA-----------QRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHY 1621
Query: 583 RATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKEL-------- 634
A KQ+ +E++E+L R +E L+KE
Sbjct: 1622 DAKKQQ-------NQELQEQL---------------------RSLEQLQKENKELRAEAE 1653
Query: 635 ----------LRTQE---ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEE 681
L+T+E + L A+ +S E H D++L + L +V D + E
Sbjct: 1654 RLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQL-RDLGKFQVATDALKSREP 1712
Query: 682 Q-NLQLQKTLQQLRQDCEEASKAKMVAEAEAT------VLGQRRAAVETTLRETQEENDE 734
Q QL ++ L CEE + + ++ T V G+ + + L E +
Sbjct: 1713 QAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPISQRLPPKVESLES 1772
Query: 735 F------RRRILGLEQQLKETRGL-VDGGEAVEARLRDKLQRLE---AEKQQLEEALNAS 784
R LE L + +D G + R Q + +K +EE +A+
Sbjct: 1773 LYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRRTTQIINITMTKKLDVEEPDSAN 1832
Query: 785 QEEEGSLAAAKRALEARLEEAQRGLARLG 813
+ +A R + + LARLG
Sbjct: 1833 SSFYSTRSAPASQASLRATSSTQSLARLG 1861
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 164 bits (415), Expect = 5e-40
Identities = 245/1062 (23%), Positives = 442/1062 (41%), Gaps = 115/1062 (10%)
Query: 207 EQRKRSKSLDSRLPRDTFEERERQSTNHWTSSTKYDNHVGTSK------QPAQSQNLSPL 260
E +RS + + R +F E+ Q + + HV ++ + AQ Q +
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQ-----LERSLQEEHVAVAQLREEAERRAQQQAEAER 1622
Query: 261 SGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQ-EAAPPGSVDHMKATIY 319
+ R+ + W L++ E R Q + Q KS ++Q E A + KA
Sbjct: 1623 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1682
Query: 320 GILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE-----LQRK 374
+ + +E E +R+++ + + +A QGE R++ E LQR+
Sbjct: 1683 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Query: 375 LDEEVKKRQKLEPSQVGLERQLE------EKTEECSRL-----QELLERRKGEAQQSNKE 423
+KRQ+LE + ++E + EE SR ++ LE G ++ +E
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Query: 424 LQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAK-----------EVLLKDLLET 472
++ L ++ + R E + + + V + A E+ LK+
Sbjct: 1803 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1862
Query: 473 RELLEEVLEG----KQRVEEQLRLR----ERELTALKGALKEEVASRDQEVEHV---RQQ 521
E L + E ++R+EEQ E L L+ A E+ + VE R+Q
Sbjct: 1863 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1922
Query: 522 YQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKED 581
+ + L+ S + A A LE E ++ + R E+ E Q +E
Sbjct: 1923 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQLAAEEER 1981
Query: 582 LRATKQELLQLRMEKEE----MEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRT 637
R +E +Q + EE + E++E L+ ++E+AR Q + +L +
Sbjct: 1982 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2041
Query: 638 QEELKELQAERQSQEVAGRHRDRELEKQLAV-------LRVEADRGR----ELEEQNLQL 686
+ K LQAE ++ A + +++EL++ L LR EA+ R E EE +Q
Sbjct: 2042 AAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2100
Query: 687 QKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDE-FRRRILGLEQQ 745
++ Q R+ EEA + K AE +A Q +AA E +E ++E + L Q+
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2160
Query: 746 LKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEA 805
+ + E LR K Q +E E L L + ++ L + L+A EA
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQ-VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219
Query: 806 QRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLL-----DRTVDRLNKELEK 860
R +++ +E ++ +EE L + KA +E + R L D T L +E EK
Sbjct: 2220 ARQRSQVEEELFSVRVQMEE-------LSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2272
Query: 861 IGEDSKQALQQLQAQLED--YKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRL 918
+ + +++A + A E ++ A ++A + A+ E + +RL+ E + L
Sbjct: 2273 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332
Query: 919 RQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQD-DRARQLKGLEEKVSRLETE 977
+Q + +Q + + DKE +AQ+L +E + +R+ + +R RQL+ + + RL+
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLA---EETQGFQRTLEAERQRQLE-MSAEAERLKLR 2388
Query: 978 LDEEKNTVELLTDRVNRGRDQVDQL-----RTELMQERSAR--QDLECDKISLERQNKDL 1030
+ E + R R Q +++ RTEL + Q LE + + + L
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2448
Query: 1031 KTRLASSEGFQKP---SASLSQLES-------QNQLLQERLQAEER---EKTVLQSTNRK 1077
+ +A E ++ A L QL+S Q QLLQE ++ EK L R
Sbjct: 2449 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508
Query: 1078 LERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEE 1137
+E++ +L +DE +++ +RQ + E+E +RL ++A+R E
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQ-------QRQQQQMEQERQRLVASMEEARRRQHE 2561
Query: 1138 QHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEE 1179
E + Q ++ LE+ ++ A E+ E L EE
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2603
Score = 147 bits (370), Expect = 8e-35
Identities = 242/1007 (24%), Positives = 436/1007 (43%), Gaps = 137/1007 (13%)
Query: 270 QDWVLQSFE----EPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREG 325
+ W L +F E +R A L +++ LRD Q+A G D + A RE
Sbjct: 907 RSWSLATFRTLKPEEQRQALHSLELHYQA---FLRDSQDAGGFGPEDRLMAE-----REY 958
Query: 326 SSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGEL--------TRKVEELQRKLDE 377
S S +L+ ++ S + ++ ++ TR V L+ LD+
Sbjct: 959 GSCSH-----HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1013
Query: 378 E--------VKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKR 429
E + ++QK + GL + + + E ++ L E A EL+
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA-APTLRSELELTLG 1072
Query: 430 LLDQGEDLRHGLETQVMELQNKLKHVQGPEP---AKEVLLKDLLETRELLEEVLEGKQRV 486
L+Q L ++ + ++ QG E A E LK+ L E LE +
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKAS 1131
Query: 487 EEQLRLRERELTALKGALKEEVASRDQEVEHVRQQY-QRDTEQLR---RSMQDATQDHAV 542
++LR + AL++E+ + E ++Q++ +RD E R R Q + AV
Sbjct: 1132 LKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV 1191
Query: 543 L---EAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKE--------DLRATKQELLQ 591
L + ++++ L R L R E+++ G W ++ +E D +A +++L Q
Sbjct: 1192 LAQTDVRQRELEQLGRQL-RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1250
Query: 592 LRMEKEEMEEELGEKIEVLQRELEQARASAGDTR-QVEVLKKELLRTQEELKELQAERQS 650
+ EE+E GEK+E QR +Q + D Q+ K +L K+ + + S
Sbjct: 1251 EQALLEEIERH-GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309
Query: 651 QEVAGRHRD-RELEKQLAVL-------------------RVEADRGRELEEQNLQLQKTL 690
+ V + D R +L L R+ + E E+ +++ L
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1369
Query: 691 QQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETR 750
++ RQ E ++AK AE EA L QR E + + +R I QQL+++
Sbjct: 1370 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1429
Query: 751 GLVDGGEAVEARLRDKLQ-RLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGL 809
+A +A ++ + R+E E + + L A++ + G +AL AR EEA+
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489
Query: 810 ARLGQEQQTLNRALEEEGKQR-----EVLRRGKAELE---EQKRLLDRTVDRLNKELEKI 861
+ +E + L R +++E +++ E+ R KAE E E++R L + ++ L + E+
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL-QALEELRLQAEEA 1548
Query: 862 GEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDE---IQRL 918
+QA + Q++ E A+R A+A+ Q+K AS AEKT+ LQ+E + +L
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRS-AEAELQSKR-ASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 919 RQ-----ALQASQAERDTA-------------------RLDKELLAQRLQGLEQEAENKK 954
R+ A Q ++AER RL E +AQ+ + EAE +K
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 955 RSQDDRARQLKGLEEKVSR----LETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQER 1010
+ AR+ EE+ R E EL++++ E + ++ +LR E Q
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 1011 SARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQ-LLQERLQAEEREKT 1069
RQ LE + L+R+ A+++ Q+ A L+++ ++ + LL + +AEE ++
Sbjct: 1727 QQRQLLEEELARLQRE------AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 1070 VLQSTNRKLER---KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEI-ERLD 1125
+ + ++LE + +EL+ + R + K Q L + RQ EAE + E+L
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 1126 G------LRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAE 1166
L+ +A+ ++E+ NE+L+ R+ E R+ AA+
Sbjct: 1841 AIGEATRLKTEAEIALKEKEAENERLR-RLAEDEAFQRRRLEEQAAQ 1886
Score = 143 bits (361), Expect = 9e-34
Identities = 201/875 (22%), Positives = 370/875 (42%), Gaps = 125/875 (14%)
Query: 278 EEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKV 337
EE RS + + + ++ R+ E A ++A R+ E + R++
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAA-----RLRALAEEAKRQRQLAEEDAARQRA 1829
Query: 338 S---LVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLER 394
++ EK+ + + T+A E + E L+R ++E +R++LE +
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889
Query: 395 QLEEKTEECSRLQEL-LERRKG-------EAQQSNKELQNMK------------------ 428
+EE+ + + + LER+KG + +Q +E+ +K
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 429 RLLDQGEDLRHGLETQVMELQNKLKHVQGPE----PAKEVLLKDLLETREL-------LE 477
R+ ED E +E + + E A+E + K L E LE
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 478 EVLEGKQRVEEQLRLRER------------------ELTALKGALKEEVASRDQEVEHVR 519
EV K +VEE RLRER L A + A V ++QE++
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 520 QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNK 579
QQ Q +QLR + A + A EAE ++ A +RE ++ + + + Q +
Sbjct: 2070 QQEQSVLDQLRGEAEAARR--AAEEAEEARVQA-----EREAAQSRRQVEEAERLKQSAE 2122
Query: 580 EDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQE 639
E +A Q ++E E+E + + Q L Q +A+ + + + ++ LR +
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2182
Query: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE 699
++++ + Q H+ L+++L L+ EA E Q Q+++ L +R EE
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT---EAARQRSQVEEELFSVRVQMEE 2239
Query: 700 ASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRR------RILGLEQQLKETRGLV 753
SK K EAE L R + T R QEE ++ ++ R+ Q+ R L
Sbjct: 2240 LSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 754 DGGEA-----VEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRG 808
+ A E L++K+Q ++ + EA Q++E + A+R E + + AQ+
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ- 2356
Query: 809 LARLGQEQQTLNRALEEEGKQR-------EVLRRGKAELEEQKRLLDRTVDRLNKELEKI 861
L +E Q R LE E +++ E L+ AE+ + + R K+ E+I
Sbjct: 2357 ---LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 862 GE---------DSKQALQQ---LQAQLEDYK-EKARREVADAQRQAKDWASEAEKTSGGL 908
GE K L Q +Q Q D+ E+ R +A+ +R+ + EA+ L
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL----L 2469
Query: 909 SRLQDEIQRLRQA--LQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKG 966
+E+Q ++Q LQ +QA + + +K+ L QR + +EQE ++ D + +
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2529
Query: 967 LEEKVSRLETELDEEKN----TVELLTDRVNRGRDQVDQLRTELMQ-ERSARQDLECDKI 1021
L E+ R + ++++E+ ++E R + + V + + EL Q E+ RQ E
Sbjct: 2530 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL--- 2586
Query: 1022 SLERQNKDLKTRLASSEGFQKPSASLSQLESQNQL 1056
L +N+ L+ +L E + + + S+ + +Q+
Sbjct: 2587 -LAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2620
Score = 133 bits (335), Expect = 9e-31
Identities = 177/778 (22%), Positives = 330/778 (42%), Gaps = 101/778 (12%)
Query: 315 KATIYGILREGSSESETSVRRKVSLVLEKM-------QPLVMVSSGSTKAVAGQGELTRK 367
KA I L + S++ + R+ LV + + + ++ + + KA AG+ EL +
Sbjct: 1888 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1947
Query: 368 VEELQRKLDEEVKKRQKLEPSQVGLERQL-----EEKTEECSRLQELLERRKGEAQQSNK 422
+ ++ ++ ++ +++ E + +RQL + E R+Q+ L + A+Q
Sbjct: 1948 LGRIRSNAEDTLRSKEQAE-LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006
Query: 423 ELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEG 482
L+ ++RL + E+ R E E +L+ Q E A++ L E + V +
Sbjct: 2007 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--EAAQKRLQA---EEKAHAFAVQQK 2061
Query: 483 KQRVEEQLRLRERELTALKGALKEEVASRD-QEVEHVRQQYQRDTEQLRRSMQDATQDHA 541
+Q +++ L+ + L L+G + E A R +E E R Q +R+ Q RR +++A +
Sbjct: 2062 EQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119
Query: 542 VLEAERQ---KMSALVRGLQRELEETSEETGHWQ--SMFQKNKEDLRATK---------- 586
E + Q + A L++E E+ + + ++ QK D K
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 587 ------QELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEE 640
QEL LR++ EE + + E LQR +A +A QVE + EE
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Query: 641 LKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEA 700
L +L+A +++ A RD++ ++ L+ EA++ +++ E+ +L Q EA
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRF--LQEEAEKMKQVAEEAARLSVAAQ-------EA 2290
Query: 701 SKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVE 760
++ + +AE + L Q+RA E L+E + E R E ++ + ++
Sbjct: 2291 ARLRQLAEED---LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2347
Query: 761 ARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLN 820
Q+L E Q + L A ++ + ++A L+ R+ E R AR ++ Q
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2407
Query: 821 RALEEEGKQ----------------------------REVLRRGKAELEEQKRLLDRTVD 852
+ EE G++ E LR AELE +K L +
Sbjct: 2408 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2467
Query: 853 RLNKELEKIGE-DSKQALQQLQAQLEDYKEKA----------RREVADAQRQAKDWASEA 901
L + E++ +Q LQ+ QA + + + +E A ++ +D ++A
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527
Query: 902 EKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDD-- 959
++ R Q ++++ RQ L AS E + + E +R Q Q+ E ++R Q++
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587
Query: 960 -----RAR-QLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERS 1011
R R QL+ LEE+ +E + T + GRD +D E E S
Sbjct: 2588 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2645
Score = 111 bits (277), Expect = 5e-24
Identities = 151/762 (19%), Positives = 328/762 (43%), Gaps = 93/762 (12%)
Query: 200 RTRMLPPEQRKRSKSLDSRLPRDTFEERER--------QSTNHWTSSTKYDNHVGTSKQP 251
R R L E+ +R + + R+ + E E + + + + +
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2030
Query: 252 AQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQ-DPTMLQFKSTPDLLRDQQEAAPPGS 310
++ L ++ R + +F ++ + T+ Q +S D LR + EAA +
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Query: 311 VDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE 370
E + E+ R+ + +++ + + + + + E+
Sbjct: 2091 -------------EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 371 LQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRL 430
L+++ ++E +R + E + + ++ + + E+ + E R+K + +Q EL ++
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ---ELTTLRLQ 2194
Query: 431 LDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQL 490
L++ + ++ L+ ++ L+ + E ++L R +EE+ + K R+E +
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQVE---EELFSVRVQMEELSKLKARIEAEN 2251
Query: 491 R---LRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAER 547
R LR+++ T + L+EE Q E + +L + Q+A + + E +
Sbjct: 2252 RALILRDKDNT--QRFLQEEAEKMKQVAE--------EAARLSVAAQEAARLRQLAEEDL 2301
Query: 548 QKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKI 607
+ AL + +E + +E ++ + ++ +++ +L+ +KE+M ++L E+
Sbjct: 2302 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2361
Query: 608 EVLQRELEQARAS----AGDTRQVEVLKKELLRTQEELKE--LQAERQSQEVAGRHRDRE 661
+ QR LE R + + ++++ E+ R Q +E + +Q++E+ + E
Sbjct: 2362 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2421
Query: 662 LEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAV 721
L Q V V+ LE Q Q ++LR+ E + K + EA +L + +
Sbjct: 2422 LATQEKVTLVQT-----LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 722 ETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEAL 781
+T +E Q L+ET+ L + + L + + +E EK +LE+
Sbjct: 2477 QTVQQE----------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520
Query: 782 NASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQR----EVLRRGK 837
++E + A R EE QR ++ QE+Q L ++EE +++ E +RR +
Sbjct: 2521 ----QDEVAKAQQLR------EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570
Query: 838 AELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQ-----R 892
EL++ ++ + + L +E +++ E + +Q +A L +E +VA + R
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2630
Query: 893 QAKDW---ASEAEKTSGGLSRLQDEIQRLRQA--LQASQAER 929
A D +E E + GL R + QRL++A L A + +R
Sbjct: 2631 DALDGPAAEAEPEHSFDGLRR-KVSAQRLQEAGILSAEELQR 2671
Score = 103 bits (256), Expect = 1e-21
Identities = 185/831 (22%), Positives = 354/831 (42%), Gaps = 128/831 (15%)
Query: 397 EEKTEECSR-LQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHV 455
E + CS Q+LL+ + AQ+ ++ +R + + +D+R LE ++L+
Sbjct: 955 EREYGSCSHHYQQLLQSLEQGAQEESR----CQRCISELKDIRLQLEACETRTVHRLRLP 1010
Query: 456 QGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEV 515
EPA+E + + E ++ EV EG + +L ++ AL E
Sbjct: 1011 LDKEPARECAQR-IAEQQKAQAEV-EGLGKGVARLSAEAEKVLALP------------EP 1056
Query: 516 EHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQ--RELEETSEETGHWQS 573
+ + E ++ A+ + + +S ++RG Q E+ EE
Sbjct: 1057 SPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1116
Query: 574 MFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKE 633
+L ATK L +LR + E + + L+ EL A+ E
Sbjct: 1117 AVPATLPELEATKASLKKLRAQAEAQQPTF----DALRDELRGAQEVG-----------E 1161
Query: 634 LLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQ---KTL 690
L+ + ++++ ER + VA + LE+ AVL R RELE+ QL+ ++
Sbjct: 1162 RLQQRHGERDVEVERWRERVA-----QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1216
Query: 691 QQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETR 750
L ++A + + +A Q AV LR+ Q +E R +E+ + +
Sbjct: 1217 DPLGAWLQDARRRQEQIQAMPLADSQ---AVREQLRQEQALLEEIERHGEKVEECQRFAK 1273
Query: 751 GLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQE---EEGSLAAAKRALEARLEEAQR 807
++ ++D +L K QLE + +++ + GS + + ++ R ++
Sbjct: 1274 QYINA-------IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE- 1325
Query: 808 GLARLGQE-----QQTLNRALEEE-------GKQREVLRRGKAELEEQKRLLDR------ 849
L L + +TL R EEE ++RE L +A LE+Q++L +
Sbjct: 1326 -LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384
Query: 850 TVDRLNKEL-----------EKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWA 898
+R KEL E+ D++Q + +Q +L+ ++ + E+ QAK A
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI-----QAK--A 1437
Query: 899 SEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELL--------AQRLQGLEQEA 950
+AE R+++EI+ +R L+A++ +R A + + L AQ+ Q E+
Sbjct: 1438 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497
Query: 951 ENKKRSQDDRARQLKGLEEKVSRLETELD---EEKNTVELLTDRVNRGRDQVDQLR-TEL 1006
+++ QD+ R+ + E SR++ E + E++ ++ L + + + +LR E+
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1557
Query: 1007 MQERSARQDLECDKISLERQNKDLKTRLAS-----SEGFQKPSASLSQLESQNQLLQERL 1061
+ R + LE + S E + + + A Q+ +++QL + + R
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRA 1614
Query: 1062 QAEEREKTVLQSTNRKLER---KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAE 1118
Q + + + R+LER K E ++++ + + V QK SL ++Q +EAE
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANE-ALRLRLQAEEVAQQK---SLAQAEAEKQKEEAE 1670
Query: 1119 EEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESAL 1169
E R R KA+ + Q E+ EQ + + L + + ++ R AAE L
Sbjct: 1671 REARR----RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ--RLAAEQEL 1715
Score = 86.3 bits (212), Expect = 2e-16
Identities = 160/694 (23%), Positives = 301/694 (43%), Gaps = 78/694 (11%)
Query: 520 QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQS---MFQ 576
Q +RD QL RS AT E +RQ + +L Q L ++ + G M +
Sbjct: 897 QSLRRDV-QLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE 955
Query: 577 KNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLR 636
+ Q+LLQ +E+ EE ++ +++ + + A +TR V L+ L
Sbjct: 956 REYGSCSHHYQQLLQ-SLEQGAQEESRCQRCISELKDI-RLQLEACETRTVHRLRLPL-- 1011
Query: 637 TQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQD 696
+E +E A+R +++ + L K +A L EA++ L E + LR +
Sbjct: 1012 DKEPAREC-AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSE 1066
Query: 697 CE-EASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGL--- 752
E K + V A L ++ + +R TQ + R E+QLKE + +
Sbjct: 1067 LELTLGKLEQVRSLSAIYL-EKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPAT 1121
Query: 753 VDGGEAVEARLRDKLQRLEAEKQQ-----LEEALNASQEEEGSLAAAKRALEARLEEAQR 807
+ EA +A L K R +AE QQ L + L +QE L + +E +
Sbjct: 1122 LPELEATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1179
Query: 808 GLARLGQEQQTL-------NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEK 860
+A+L + Q + R LE+ G+Q R L + R +++
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1239
Query: 861 IGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQ 920
+ ++ L+Q QA LE+ E+ +V + QR AK + + + L + +++ +
Sbjct: 1240 DSQAVREQLRQEQALLEEI-ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-- 1296
Query: 921 ALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETE--L 978
AS A++ + E + Q L ++ +K + E + R+E E L
Sbjct: 1297 ---ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT---SQYIKFISETLRRMEEEERL 1350
Query: 979 DEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE 1038
E++ E R+++ ++ L ++R + K ER+ K+L+ R+ E
Sbjct: 1351 AEQQRAEE---------RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM-QEE 1400
Query: 1039 GFQKPSASLSQLESQNQLLQERL-----------QAEEREKTVLQSTNRKLERKVKELSI 1087
++ A++ + Q + +QE L QA+ R+ + + ++E +++ + +
Sbjct: 1401 VVRREEAAVDA-QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459
Query: 1088 QIE-DERQHVNDQKDQLSLRVKA--LKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQ 1144
Q+E ERQ + + +LR +A + Q +A+EE ER LR++ Q E + + + +
Sbjct: 1460 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER---LRRQVQDESQRKRQAEVE 1516
Query: 1145 LQARIKSLEKDSWRKASRSAAESALKNEGLSSDE 1178
L +R+K+ E ++ R+ R A AL+ L ++E
Sbjct: 1517 LASRVKA-EAEAAREKQR--ALQALEELRLQAEE 1547
Score = 62.4 bits (150), Expect = 3e-09
Identities = 86/427 (20%), Positives = 178/427 (41%), Gaps = 27/427 (6%)
Query: 285 QDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKM 344
+D T + + ++ E A SV +A L E + ++ K ++ EKM
Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK--MLKEKM 2316
Query: 345 QPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTE--- 401
Q + + +A Q + E+ +R +++ + Q+L G +R LE + +
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 402 ECSRLQELLERRKGEAQQSNKELQ-NMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEP 460
E S E L+ R E ++ + + +R Q E++ L + Q K+ VQ E
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 461 AKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHV-- 518
++ D RE + E+ K++++++ +L + + ++ +E++ Q ++
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 519 -----RQQYQRDTEQLRRSMQDATQDHAV----LEAERQKMSALVRGLQRELEETSEETG 569
Q +R EQ + ++ QD L E+Q+ + ++ L + EE
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556
Query: 570 HWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKI-EVLQRELEQARASAGDTRQVE 628
Q ++ + Q+L Q R ++EE+ E +++ E LQ EQ RA+ + +V
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616
Query: 629 VLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQK 688
+ +T ++ + + E H L ++++ R L+E + +
Sbjct: 2617 ASQVAATKTLPNGRD-ALDGPAAEAEPEHSFDGLRRKVSAQR--------LQEAGILSAE 2667
Query: 689 TLQQLRQ 695
LQ+L Q
Sbjct: 2668 ELQRLAQ 2674
Score = 48.1 bits (113), Expect = 5e-05
Identities = 126/582 (21%), Positives = 230/582 (39%), Gaps = 101/582 (17%)
Query: 455 VQGPEPAKEVLL---KDLLETRELLEEVLEGKQRVEEQLRLRE-RELTAL--------KG 502
V P+P ++ ++ L + + +V +G + E QLR +E REL L
Sbjct: 241 VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTA 300
Query: 503 ALKEE-VASRDQEVEHVRQQYQRDTEQ--------------LRRSMQDATQ--------D 539
A +E S +E+E + Q+ + E + +S++ A Q
Sbjct: 301 AFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG 360
Query: 540 HAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEM 599
+ L+ E++ V L+RE + SE E L ++ + +L+ME
Sbjct: 361 YHPLDVEKEWGKLHVAILEREKQLRSEF------------ERLECLQRIVTKLQMEAGLC 408
Query: 600 EEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRD 659
EE+L + +LQ ++ A R EV +++L + ++ L + Q+ + GRH
Sbjct: 409 EEQLNQADALLQSDVRLLAAGKVPQRAGEV-ERDLDKADSMIRLLFNDVQTLK-DGRHPQ 466
Query: 660 RELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRA 719
E + V R+ + L +T LR A+ A VA+ + +R
Sbjct: 467 GE-QMYRRVYRLH---------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPE 516
Query: 720 AVETTLRETQ------EEND------EFRRRILGLEQQLKETRGLVDGGEAVEARLR--- 764
++TLR Q EEN E+ + +E QL RGL E A++
Sbjct: 517 LEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR 576
Query: 765 -DKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRAL 823
D+ Q A + + L + L + +A LE +A +E LN
Sbjct: 577 SDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 636
Query: 824 EEE--------------GKQREVLRRGKAELEEQK-RLLDRTVDRLNKELEKIGEDSKQA 868
EEE K+ + EL+E+K + L DRL +E ++
Sbjct: 637 EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRE----DHPARPT 692
Query: 869 LQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAE 928
++ QA L+ + + K+ A+ + S + + ++Q+L++AL+ +
Sbjct: 693 VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQKLQEALRRKYS- 750
Query: 929 RDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEK 970
D+ RL+ L Q+A+++K ++ L GL ++
Sbjct: 751 -----CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 787
Score = 35.8 bits (81), Expect = 0.25
Identities = 117/542 (21%), Positives = 215/542 (39%), Gaps = 92/542 (16%)
Query: 626 QVEVLKKELLRTQE-ELKELQAER-------QSQEVAGR---------HRDRELEKQLAV 668
++E+L + L+ +E EL +A++ QS E A + + ++EK+
Sbjct: 313 EIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGK 372
Query: 669 LRV---EADRGRELEEQNLQ-LQKTLQQLRQD---CEEA-SKAKMVAEAEATVLG----- 715
L V E ++ E + L+ LQ+ + +L+ + CEE ++A + +++ +L
Sbjct: 373 LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVP 432
Query: 716 QRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQ 775
QR VE L ++ D R + Q LK+ R GE + R+ +RL A +
Sbjct: 433 QRAGEVERDL----DKADSMIRLLFNDVQTLKDGRH--PQGEQMYRRVYRLHERLVAIRT 486
Query: 776 QLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRR 835
+ L A G A A + + L+ QR R E TL L+
Sbjct: 487 EYNLRLKA-----GVAAPATQVAQVTLQSVQR---RPELEDSTLR-----------YLQD 527
Query: 836 GKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAK 895
A +EE + +D ++ + S + L Q +E+++ K R +D + Q
Sbjct: 528 LLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ---SIEEFRAKIERARSD-EGQLS 583
Query: 896 DWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGL-EQEAENKK 954
A + L RL + +L + +A ++ + L L E+E E
Sbjct: 584 PATRGAYRDC--LGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVG 641
Query: 955 RSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQ 1014
DR + +E S L EL+ ++ ++ L + +R L ++ AR
Sbjct: 642 FDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDR----------LLREDHPARP 691
Query: 1015 DLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQST 1074
+E + +L+ Q + E K +A+ Q S + +AE + + + ++
Sbjct: 692 TVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVR------EAEGQLQKLQEAL 745
Query: 1075 NRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQRE 1134
RK ++ED Q D+K+QL+ E L GL K+A+
Sbjct: 746 RRKYSCDRSATVTRLEDLLQDAQDEKEQLN--------------EYKGHLSGLAKRAKAV 791
Query: 1135 VE 1136
V+
Sbjct: 792 VQ 793
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 164 bits (415), Expect = 5e-40
Identities = 245/1062 (23%), Positives = 442/1062 (41%), Gaps = 115/1062 (10%)
Query: 207 EQRKRSKSLDSRLPRDTFEERERQSTNHWTSSTKYDNHVGTSK------QPAQSQNLSPL 260
E +RS + + R +F E+ Q + + HV ++ + AQ Q +
Sbjct: 1572 ETAQRSAEAELQSKRASFAEKTAQ-----LERSLQEEHVAVAQLREEAERRAQQQAEAER 1626
Query: 261 SGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQ-EAAPPGSVDHMKATIY 319
+ R+ + W L++ E R Q + Q KS ++Q E A + KA
Sbjct: 1627 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1686
Query: 320 GILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE-----LQRK 374
+ + +E E +R+++ + + +A QGE R++ E LQR+
Sbjct: 1687 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1746
Query: 375 LDEEVKKRQKLEPSQVGLERQLE------EKTEECSRL-----QELLERRKGEAQQSNKE 423
+KRQ+LE + ++E + EE SR ++ LE G ++ +E
Sbjct: 1747 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1806
Query: 424 LQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAK-----------EVLLKDLLET 472
++ L ++ + R E + + + V + A E+ LK+
Sbjct: 1807 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1866
Query: 473 RELLEEVLEG----KQRVEEQLRLR----ERELTALKGALKEEVASRDQEVEHV---RQQ 521
E L + E ++R+EEQ E L L+ A E+ + VE R+Q
Sbjct: 1867 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1926
Query: 522 YQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKED 581
+ + L+ S + A A LE E ++ + R E+ E Q +E
Sbjct: 1927 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQLAAEEER 1985
Query: 582 LRATKQELLQLRMEKEE----MEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRT 637
R +E +Q + EE + E++E L+ ++E+AR Q + +L +
Sbjct: 1986 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2045
Query: 638 QEELKELQAERQSQEVAGRHRDRELEKQLAV-------LRVEADRGR----ELEEQNLQL 686
+ K LQAE ++ A + +++EL++ L LR EA+ R E EE +Q
Sbjct: 2046 AAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2104
Query: 687 QKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDE-FRRRILGLEQQ 745
++ Q R+ EEA + K AE +A Q +AA E +E ++E + L Q+
Sbjct: 2105 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2164
Query: 746 LKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEA 805
+ + E LR K Q +E E L L + ++ L + L+A EA
Sbjct: 2165 QAADAEMEKHKKFAEQTLRQKAQ-VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2223
Query: 806 QRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLL-----DRTVDRLNKELEK 860
R +++ +E ++ +EE L + KA +E + R L D T L +E EK
Sbjct: 2224 ARQRSQVEEELFSVRVQMEE-------LSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2276
Query: 861 IGEDSKQALQQLQAQLED--YKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRL 918
+ + +++A + A E ++ A ++A + A+ E + +RL+ E + L
Sbjct: 2277 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2336
Query: 919 RQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQD-DRARQLKGLEEKVSRLETE 977
+Q + +Q + + DKE +AQ+L +E + +R+ + +R RQL+ + + RL+
Sbjct: 2337 QQQKELAQEQARRLQEDKEQMAQQLA---EETQGFQRTLEAERQRQLE-MSAEAERLKLR 2392
Query: 978 LDEEKNTVELLTDRVNRGRDQVDQL-----RTELMQERSAR--QDLECDKISLERQNKDL 1030
+ E + R R Q +++ RTEL + Q LE + + + L
Sbjct: 2393 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2452
Query: 1031 KTRLASSEGFQKP---SASLSQLES-------QNQLLQERLQAEER---EKTVLQSTNRK 1077
+ +A E ++ A L QL+S Q QLLQE ++ EK L R
Sbjct: 2453 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2512
Query: 1078 LERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEE 1137
+E++ +L +DE +++ +RQ + E+E +RL ++A+R E
Sbjct: 2513 IEQEKAKLEQLFQDEVAKAQQLREEQ-------QRQQQQMEQERQRLVASMEEARRRQHE 2565
Query: 1138 QHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEE 1179
E + Q ++ LE+ ++ A E+ E L EE
Sbjct: 2566 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2607
Score = 147 bits (370), Expect = 8e-35
Identities = 242/1007 (24%), Positives = 436/1007 (43%), Gaps = 137/1007 (13%)
Query: 270 QDWVLQSFE----EPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREG 325
+ W L +F E +R A L +++ LRD Q+A G D + A RE
Sbjct: 911 RSWSLATFRTLKPEEQRQALHSLELHYQA---FLRDSQDAGGFGPEDRLMAE-----REY 962
Query: 326 SSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGEL--------TRKVEELQRKLDE 377
S S +L+ ++ S + ++ ++ TR V L+ LD+
Sbjct: 963 GSCSH-----HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1017
Query: 378 E--------VKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKR 429
E + ++QK + GL + + + E ++ L E A EL+
Sbjct: 1018 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA-APTLRSELELTLG 1076
Query: 430 LLDQGEDLRHGLETQVMELQNKLKHVQGPEP---AKEVLLKDLLETRELLEEVLEGKQRV 486
L+Q L ++ + ++ QG E A E LK+ L E LE +
Sbjct: 1077 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKAS 1135
Query: 487 EEQLRLRERELTALKGALKEEVASRDQEVEHVRQQY-QRDTEQLR---RSMQDATQDHAV 542
++LR + AL++E+ + E ++Q++ +RD E R R Q + AV
Sbjct: 1136 LKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV 1195
Query: 543 L---EAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKE--------DLRATKQELLQ 591
L + ++++ L R L R E+++ G W ++ +E D +A +++L Q
Sbjct: 1196 LAQTDVRQRELEQLGRQL-RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1254
Query: 592 LRMEKEEMEEELGEKIEVLQRELEQARASAGDTR-QVEVLKKELLRTQEELKELQAERQS 650
+ EE+E GEK+E QR +Q + D Q+ K +L K+ + + S
Sbjct: 1255 EQALLEEIERH-GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1313
Query: 651 QEVAGRHRD-RELEKQLAVL-------------------RVEADRGRELEEQNLQLQKTL 690
+ V + D R +L L R+ + E E+ +++ L
Sbjct: 1314 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1373
Query: 691 QQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETR 750
++ RQ E ++AK AE EA L QR E + + +R I QQL+++
Sbjct: 1374 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1433
Query: 751 GLVDGGEAVEARLRDKLQ-RLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGL 809
+A +A ++ + R+E E + + L A++ + G +AL AR EEA+
Sbjct: 1434 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1493
Query: 810 ARLGQEQQTLNRALEEEGKQR-----EVLRRGKAELE---EQKRLLDRTVDRLNKELEKI 861
+ +E + L R +++E +++ E+ R KAE E E++R L + ++ L + E+
Sbjct: 1494 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL-QALEELRLQAEEA 1552
Query: 862 GEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDE---IQRL 918
+QA + Q++ E A+R A+A+ Q+K AS AEKT+ LQ+E + +L
Sbjct: 1553 ERRLRQAEVERARQVQVALETAQRS-AEAELQSKR-ASFAEKTAQLERSLQEEHVAVAQL 1610
Query: 919 RQ-----ALQASQAERDTA-------------------RLDKELLAQRLQGLEQEAENKK 954
R+ A Q ++AER RL E +AQ+ + EAE +K
Sbjct: 1611 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1670
Query: 955 RSQDDRARQLKGLEEKVSR----LETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQER 1010
+ AR+ EE+ R E EL++++ E + ++ +LR E Q
Sbjct: 1671 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1730
Query: 1011 SARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQ-LLQERLQAEEREKT 1069
RQ LE + L+R+ A+++ Q+ A L+++ ++ + LL + +AEE ++
Sbjct: 1731 QQRQLLEEELARLQRE------AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1784
Query: 1070 VLQSTNRKLER---KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEI-ERLD 1125
+ + ++LE + +EL+ + R + K Q L + RQ EAE + E+L
Sbjct: 1785 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1844
Query: 1126 G------LRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAE 1166
L+ +A+ ++E+ NE+L+ R+ E R+ AA+
Sbjct: 1845 AIGEATRLKTEAEIALKEKEAENERLR-RLAEDEAFQRRRLEEQAAQ 1890
Score = 143 bits (361), Expect = 9e-34
Identities = 201/875 (22%), Positives = 370/875 (42%), Gaps = 125/875 (14%)
Query: 278 EEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKV 337
EE RS + + + ++ R+ E A ++A R+ E + R++
Sbjct: 1779 EEESRSTSEKSKQRLEAEAGRFRELAEEAA-----RLRALAEEAKRQRQLAEEDAARQRA 1833
Query: 338 S---LVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLER 394
++ EK+ + + T+A E + E L+R ++E +R++LE +
Sbjct: 1834 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1893
Query: 395 QLEEKTEECSRLQEL-LERRKG-------EAQQSNKELQNMK------------------ 428
+EE+ + + + LER+KG + +Q +E+ +K
Sbjct: 1894 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1953
Query: 429 RLLDQGEDLRHGLETQVMELQNKLKHVQGPE----PAKEVLLKDLLETREL-------LE 477
R+ ED E +E + + E A+E + K L E LE
Sbjct: 1954 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2013
Query: 478 EVLEGKQRVEEQLRLRER------------------ELTALKGALKEEVASRDQEVEHVR 519
EV K +VEE RLRER L A + A V ++QE++
Sbjct: 2014 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2073
Query: 520 QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNK 579
QQ Q +QLR + A + A EAE ++ A +RE ++ + + + Q +
Sbjct: 2074 QQEQSVLDQLRGEAEAARR--AAEEAEEARVQA-----EREAAQSRRQVEEAERLKQSAE 2126
Query: 580 EDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQE 639
E +A Q ++E E+E + + Q L Q +A+ + + + ++ LR +
Sbjct: 2127 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2186
Query: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE 699
++++ + Q H+ L+++L L+ EA E Q Q+++ L +R EE
Sbjct: 2187 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT---EAARQRSQVEEELFSVRVQMEE 2243
Query: 700 ASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRR------RILGLEQQLKETRGLV 753
SK K EAE L R + T R QEE ++ ++ R+ Q+ R L
Sbjct: 2244 LSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2301
Query: 754 DGGEA-----VEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRG 808
+ A E L++K+Q ++ + EA Q++E + A+R E + + AQ+
Sbjct: 2302 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ- 2360
Query: 809 LARLGQEQQTLNRALEEEGKQR-------EVLRRGKAELEEQKRLLDRTVDRLNKELEKI 861
L +E Q R LE E +++ E L+ AE+ + + R K+ E+I
Sbjct: 2361 ---LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2417
Query: 862 GE---------DSKQALQQ---LQAQLEDYK-EKARREVADAQRQAKDWASEAEKTSGGL 908
GE K L Q +Q Q D+ E+ R +A+ +R+ + EA+ L
Sbjct: 2418 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL----L 2473
Query: 909 SRLQDEIQRLRQA--LQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKG 966
+E+Q ++Q LQ +QA + + +K+ L QR + +EQE ++ D + +
Sbjct: 2474 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2533
Query: 967 LEEKVSRLETELDEEKN----TVELLTDRVNRGRDQVDQLRTELMQ-ERSARQDLECDKI 1021
L E+ R + ++++E+ ++E R + + V + + EL Q E+ RQ E
Sbjct: 2534 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL--- 2590
Query: 1022 SLERQNKDLKTRLASSEGFQKPSASLSQLESQNQL 1056
L +N+ L+ +L E + + + S+ + +Q+
Sbjct: 2591 -LAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2624
Score = 133 bits (335), Expect = 9e-31
Identities = 177/778 (22%), Positives = 330/778 (42%), Gaps = 101/778 (12%)
Query: 315 KATIYGILREGSSESETSVRRKVSLVLEKM-------QPLVMVSSGSTKAVAGQGELTRK 367
KA I L + S++ + R+ LV + + + ++ + + KA AG+ EL +
Sbjct: 1892 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1951
Query: 368 VEELQRKLDEEVKKRQKLEPSQVGLERQL-----EEKTEECSRLQELLERRKGEAQQSNK 422
+ ++ ++ ++ +++ E + +RQL + E R+Q+ L + A+Q
Sbjct: 1952 LGRIRSNAEDTLRSKEQAE-LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2010
Query: 423 ELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEG 482
L+ ++RL + E+ R E E +L+ Q E A++ L E + V +
Sbjct: 2011 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--EAAQKRLQA---EEKAHAFAVQQK 2065
Query: 483 KQRVEEQLRLRERELTALKGALKEEVASRD-QEVEHVRQQYQRDTEQLRRSMQDATQDHA 541
+Q +++ L+ + L L+G + E A R +E E R Q +R+ Q RR +++A +
Sbjct: 2066 EQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2123
Query: 542 VLEAERQ---KMSALVRGLQRELEETSEETGHWQ--SMFQKNKEDLRATK---------- 586
E + Q + A L++E E+ + + ++ QK D K
Sbjct: 2124 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2183
Query: 587 ------QELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEE 640
QEL LR++ EE + + E LQR +A +A QVE + EE
Sbjct: 2184 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2243
Query: 641 LKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEA 700
L +L+A +++ A RD++ ++ L+ EA++ +++ E+ +L Q EA
Sbjct: 2244 LSKLKARIEAENRALILRDKDNTQRF--LQEEAEKMKQVAEEAARLSVAAQ-------EA 2294
Query: 701 SKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVE 760
++ + +AE + L Q+RA E L+E + E R E ++ + ++
Sbjct: 2295 ARLRQLAEED---LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2351
Query: 761 ARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLN 820
Q+L E Q + L A ++ + ++A L+ R+ E R AR ++ Q
Sbjct: 2352 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2411
Query: 821 RALEEEGKQ----------------------------REVLRRGKAELEEQKRLLDRTVD 852
+ EE G++ E LR AELE +K L +
Sbjct: 2412 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2471
Query: 853 RLNKELEKIGE-DSKQALQQLQAQLEDYKEKA----------RREVADAQRQAKDWASEA 901
L + E++ +Q LQ+ QA + + + +E A ++ +D ++A
Sbjct: 2472 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2531
Query: 902 EKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDD-- 959
++ R Q ++++ RQ L AS E + + E +R Q Q+ E ++R Q++
Sbjct: 2532 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2591
Query: 960 -----RAR-QLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERS 1011
R R QL+ LEE+ +E + T + GRD +D E E S
Sbjct: 2592 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2649
Score = 111 bits (277), Expect = 5e-24
Identities = 151/762 (19%), Positives = 328/762 (43%), Gaps = 93/762 (12%)
Query: 200 RTRMLPPEQRKRSKSLDSRLPRDTFEERER--------QSTNHWTSSTKYDNHVGTSKQP 251
R R L E+ +R + + R+ + E E + + + + +
Sbjct: 1975 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2034
Query: 252 AQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQ-DPTMLQFKSTPDLLRDQQEAAPPGS 310
++ L ++ R + +F ++ + T+ Q +S D LR + EAA +
Sbjct: 2035 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2094
Query: 311 VDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE 370
E + E+ R+ + +++ + + + + + E+
Sbjct: 2095 -------------EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2141
Query: 371 LQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRL 430
L+++ ++E +R + E + + ++ + + E+ + E R+K + +Q EL ++
Sbjct: 2142 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ---ELTTLRLQ 2198
Query: 431 LDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQL 490
L++ + ++ L+ ++ L+ + E ++L R +EE+ + K R+E +
Sbjct: 2199 LEETDHQKNLLDEELQRLKAEATEAARQRSQVE---EELFSVRVQMEELSKLKARIEAEN 2255
Query: 491 R---LRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAER 547
R LR+++ T + L+EE Q E + +L + Q+A + + E +
Sbjct: 2256 RALILRDKDNT--QRFLQEEAEKMKQVAE--------EAARLSVAAQEAARLRQLAEEDL 2305
Query: 548 QKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKI 607
+ AL + +E + +E ++ + ++ +++ +L+ +KE+M ++L E+
Sbjct: 2306 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2365
Query: 608 EVLQRELEQARAS----AGDTRQVEVLKKELLRTQEELKE--LQAERQSQEVAGRHRDRE 661
+ QR LE R + + ++++ E+ R Q +E + +Q++E+ + E
Sbjct: 2366 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2425
Query: 662 LEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAV 721
L Q V V+ LE Q Q ++LR+ E + K + EA +L + +
Sbjct: 2426 LATQEKVTLVQT-----LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2480
Query: 722 ETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEAL 781
+T +E Q L+ET+ L + + L + + +E EK +LE+
Sbjct: 2481 QTVQQE----------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2524
Query: 782 NASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQR----EVLRRGK 837
++E + A R EE QR ++ QE+Q L ++EE +++ E +RR +
Sbjct: 2525 ----QDEVAKAQQLR------EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2574
Query: 838 AELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQ-----R 892
EL++ ++ + + L +E +++ E + +Q +A L +E +VA + R
Sbjct: 2575 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2634
Query: 893 QAKDW---ASEAEKTSGGLSRLQDEIQRLRQA--LQASQAER 929
A D +E E + GL R + QRL++A L A + +R
Sbjct: 2635 DALDGPAAEAEPEHSFDGLRR-KVSAQRLQEAGILSAEELQR 2675
Score = 103 bits (256), Expect = 1e-21
Identities = 185/831 (22%), Positives = 354/831 (42%), Gaps = 128/831 (15%)
Query: 397 EEKTEECSR-LQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHV 455
E + CS Q+LL+ + AQ+ ++ +R + + +D+R LE ++L+
Sbjct: 959 EREYGSCSHHYQQLLQSLEQGAQEESR----CQRCISELKDIRLQLEACETRTVHRLRLP 1014
Query: 456 QGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEV 515
EPA+E + + E ++ EV EG + +L ++ AL E
Sbjct: 1015 LDKEPARECAQR-IAEQQKAQAEV-EGLGKGVARLSAEAEKVLALP------------EP 1060
Query: 516 EHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQ--RELEETSEETGHWQS 573
+ + E ++ A+ + + +S ++RG Q E+ EE
Sbjct: 1061 SPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1120
Query: 574 MFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKE 633
+L ATK L +LR + E + + L+ EL A+ E
Sbjct: 1121 AVPATLPELEATKASLKKLRAQAEAQQPTF----DALRDELRGAQEVG-----------E 1165
Query: 634 LLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQ---KTL 690
L+ + ++++ ER + VA + LE+ AVL R RELE+ QL+ ++
Sbjct: 1166 RLQQRHGERDVEVERWRERVA-----QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1220
Query: 691 QQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETR 750
L ++A + + +A Q AV LR+ Q +E R +E+ + +
Sbjct: 1221 DPLGAWLQDARRRQEQIQAMPLADSQ---AVREQLRQEQALLEEIERHGEKVEECQRFAK 1277
Query: 751 GLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQE---EEGSLAAAKRALEARLEEAQR 807
++ ++D +L K QLE + +++ + GS + + ++ R ++
Sbjct: 1278 QYINA-------IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE- 1329
Query: 808 GLARLGQE-----QQTLNRALEEE-------GKQREVLRRGKAELEEQKRLLDR------ 849
L L + +TL R EEE ++RE L +A LE+Q++L +
Sbjct: 1330 -LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1388
Query: 850 TVDRLNKEL-----------EKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWA 898
+R KEL E+ D++Q + +Q +L+ ++ + E+ QAK A
Sbjct: 1389 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI-----QAK--A 1441
Query: 899 SEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELL--------AQRLQGLEQEA 950
+AE R+++EI+ +R L+A++ +R A + + L AQ+ Q E+
Sbjct: 1442 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1501
Query: 951 ENKKRSQDDRARQLKGLEEKVSRLETELD---EEKNTVELLTDRVNRGRDQVDQLR-TEL 1006
+++ QD+ R+ + E SR++ E + E++ ++ L + + + +LR E+
Sbjct: 1502 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1561
Query: 1007 MQERSARQDLECDKISLERQNKDLKTRLAS-----SEGFQKPSASLSQLESQNQLLQERL 1061
+ R + LE + S E + + + A Q+ +++QL + + R
Sbjct: 1562 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRA 1618
Query: 1062 QAEEREKTVLQSTNRKLER---KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAE 1118
Q + + + R+LER K E ++++ + + V QK SL ++Q +EAE
Sbjct: 1619 QQQAEAERAREEAERELERWQLKANE-ALRLRLQAEEVAQQK---SLAQAEAEKQKEEAE 1674
Query: 1119 EEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESAL 1169
E R R KA+ + Q E+ EQ + + L + + ++ R AAE L
Sbjct: 1675 REARR----RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ--RLAAEQEL 1719
Score = 86.3 bits (212), Expect = 2e-16
Identities = 160/694 (23%), Positives = 301/694 (43%), Gaps = 78/694 (11%)
Query: 520 QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQS---MFQ 576
Q +RD QL RS AT E +RQ + +L Q L ++ + G M +
Sbjct: 901 QSLRRDV-QLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE 959
Query: 577 KNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLR 636
+ Q+LLQ +E+ EE ++ +++ + + A +TR V L+ L
Sbjct: 960 REYGSCSHHYQQLLQ-SLEQGAQEESRCQRCISELKDI-RLQLEACETRTVHRLRLPL-- 1015
Query: 637 TQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQD 696
+E +E A+R +++ + L K +A L EA++ L E + LR +
Sbjct: 1016 DKEPAREC-AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSE 1070
Query: 697 CE-EASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGL--- 752
E K + V A L ++ + +R TQ + R E+QLKE + +
Sbjct: 1071 LELTLGKLEQVRSLSAIYL-EKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPAT 1125
Query: 753 VDGGEAVEARLRDKLQRLEAEKQQ-----LEEALNASQEEEGSLAAAKRALEARLEEAQR 807
+ EA +A L K R +AE QQ L + L +QE L + +E +
Sbjct: 1126 LPELEATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1183
Query: 808 GLARLGQEQQTL-------NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEK 860
+A+L + Q + R LE+ G+Q R L + R +++
Sbjct: 1184 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1243
Query: 861 IGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQ 920
+ ++ L+Q QA LE+ E+ +V + QR AK + + + L + +++ +
Sbjct: 1244 DSQAVREQLRQEQALLEEI-ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-- 1300
Query: 921 ALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETE--L 978
AS A++ + E + Q L ++ +K + E + R+E E L
Sbjct: 1301 ---ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT---SQYIKFISETLRRMEEEERL 1354
Query: 979 DEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE 1038
E++ E R+++ ++ L ++R + K ER+ K+L+ R+ E
Sbjct: 1355 AEQQRAEE---------RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM-QEE 1404
Query: 1039 GFQKPSASLSQLESQNQLLQERL-----------QAEEREKTVLQSTNRKLERKVKELSI 1087
++ A++ + Q + +QE L QA+ R+ + + ++E +++ + +
Sbjct: 1405 VVRREEAAVDA-QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1463
Query: 1088 QIE-DERQHVNDQKDQLSLRVKA--LKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQ 1144
Q+E ERQ + + +LR +A + Q +A+EE ER LR++ Q E + + + +
Sbjct: 1464 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER---LRRQVQDESQRKRQAEVE 1520
Query: 1145 LQARIKSLEKDSWRKASRSAAESALKNEGLSSDE 1178
L +R+K+ E ++ R+ R A AL+ L ++E
Sbjct: 1521 LASRVKA-EAEAAREKQR--ALQALEELRLQAEE 1551
Score = 62.4 bits (150), Expect = 3e-09
Identities = 86/427 (20%), Positives = 178/427 (41%), Gaps = 27/427 (6%)
Query: 285 QDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKM 344
+D T + + ++ E A SV +A L E + ++ K ++ EKM
Sbjct: 2263 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK--MLKEKM 2320
Query: 345 QPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTE--- 401
Q + + +A Q + E+ +R +++ + Q+L G +R LE + +
Sbjct: 2321 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2380
Query: 402 ECSRLQELLERRKGEAQQSNKELQ-NMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEP 460
E S E L+ R E ++ + + +R Q E++ L + Q K+ VQ E
Sbjct: 2381 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2440
Query: 461 AKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHV-- 518
++ D RE + E+ K++++++ +L + + ++ +E++ Q ++
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2500
Query: 519 -----RQQYQRDTEQLRRSMQDATQDHAV----LEAERQKMSALVRGLQRELEETSEETG 569
Q +R EQ + ++ QD L E+Q+ + ++ L + EE
Sbjct: 2501 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2560
Query: 570 HWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKI-EVLQRELEQARASAGDTRQVE 628
Q ++ + Q+L Q R ++EE+ E +++ E LQ EQ RA+ + +V
Sbjct: 2561 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2620
Query: 629 VLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQK 688
+ +T ++ + + E H L ++++ R L+E + +
Sbjct: 2621 ASQVAATKTLPNGRD-ALDGPAAEAEPEHSFDGLRRKVSAQR--------LQEAGILSAE 2671
Query: 689 TLQQLRQ 695
LQ+L Q
Sbjct: 2672 ELQRLAQ 2678
Score = 48.1 bits (113), Expect = 5e-05
Identities = 126/582 (21%), Positives = 230/582 (39%), Gaps = 101/582 (17%)
Query: 455 VQGPEPAKEVLL---KDLLETRELLEEVLEGKQRVEEQLRLRE-RELTAL--------KG 502
V P+P ++ ++ L + + +V +G + E QLR +E REL L
Sbjct: 245 VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTA 304
Query: 503 ALKEE-VASRDQEVEHVRQQYQRDTEQ--------------LRRSMQDATQ--------D 539
A +E S +E+E + Q+ + E + +S++ A Q
Sbjct: 305 AFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG 364
Query: 540 HAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEM 599
+ L+ E++ V L+RE + SE E L ++ + +L+ME
Sbjct: 365 YHPLDVEKEWGKLHVAILEREKQLRSEF------------ERLECLQRIVTKLQMEAGLC 412
Query: 600 EEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRD 659
EE+L + +LQ ++ A R EV +++L + ++ L + Q+ + GRH
Sbjct: 413 EEQLNQADALLQSDVRLLAAGKVPQRAGEV-ERDLDKADSMIRLLFNDVQTLK-DGRHPQ 470
Query: 660 RELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRA 719
E + V R+ + L +T LR A+ A VA+ + +R
Sbjct: 471 GE-QMYRRVYRLH---------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPE 520
Query: 720 AVETTLRETQ------EEND------EFRRRILGLEQQLKETRGLVDGGEAVEARLR--- 764
++TLR Q EEN E+ + +E QL RGL E A++
Sbjct: 521 LEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR 580
Query: 765 -DKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRAL 823
D+ Q A + + L + L + +A LE +A +E LN
Sbjct: 581 SDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 640
Query: 824 EEE--------------GKQREVLRRGKAELEEQK-RLLDRTVDRLNKELEKIGEDSKQA 868
EEE K+ + EL+E+K + L DRL +E ++
Sbjct: 641 EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRE----DHPARPT 696
Query: 869 LQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAE 928
++ QA L+ + + K+ A+ + S + + ++Q+L++AL+ +
Sbjct: 697 VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQKLQEALRRKYS- 754
Query: 929 RDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEK 970
D+ RL+ L Q+A+++K ++ L GL ++
Sbjct: 755 -----CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 791
Score = 35.8 bits (81), Expect = 0.25
Identities = 117/542 (21%), Positives = 215/542 (39%), Gaps = 92/542 (16%)
Query: 626 QVEVLKKELLRTQE-ELKELQAER-------QSQEVAGR---------HRDRELEKQLAV 668
++E+L + L+ +E EL +A++ QS E A + + ++EK+
Sbjct: 317 EIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGK 376
Query: 669 LRV---EADRGRELEEQNLQ-LQKTLQQLRQD---CEEA-SKAKMVAEAEATVLG----- 715
L V E ++ E + L+ LQ+ + +L+ + CEE ++A + +++ +L
Sbjct: 377 LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVP 436
Query: 716 QRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQ 775
QR VE L ++ D R + Q LK+ R GE + R+ +RL A +
Sbjct: 437 QRAGEVERDL----DKADSMIRLLFNDVQTLKDGRH--PQGEQMYRRVYRLHERLVAIRT 490
Query: 776 QLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRR 835
+ L A G A A + + L+ QR R E TL L+
Sbjct: 491 EYNLRLKA-----GVAAPATQVAQVTLQSVQR---RPELEDSTLR-----------YLQD 531
Query: 836 GKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAK 895
A +EE + +D ++ + S + L Q +E+++ K R +D + Q
Sbjct: 532 LLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ---SIEEFRAKIERARSD-EGQLS 587
Query: 896 DWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGL-EQEAENKK 954
A + L RL + +L + +A ++ + L L E+E E
Sbjct: 588 PATRGAYRDC--LGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVG 645
Query: 955 RSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQ 1014
DR + +E S L EL+ ++ ++ L + +R L ++ AR
Sbjct: 646 FDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDR----------LLREDHPARP 695
Query: 1015 DLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQST 1074
+E + +L+ Q + E K +A+ Q S + +AE + + + ++
Sbjct: 696 TVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVR------EAEGQLQKLQEAL 749
Query: 1075 NRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQRE 1134
RK ++ED Q D+K+QL+ E L GL K+A+
Sbjct: 750 RRKYSCDRSATVTRLEDLLQDAQDEKEQLN--------------EYKGHLSGLAKRAKAV 795
Query: 1135 VE 1136
V+
Sbjct: 796 VQ 797
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 164 bits (415), Expect = 5e-40
Identities = 245/1062 (23%), Positives = 442/1062 (41%), Gaps = 115/1062 (10%)
Query: 207 EQRKRSKSLDSRLPRDTFEERERQSTNHWTSSTKYDNHVGTSK------QPAQSQNLSPL 260
E +RS + + R +F E+ Q + + HV ++ + AQ Q +
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQ-----LERSLQEEHVAVAQLREEAERRAQQQAEAER 1622
Query: 261 SGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQ-EAAPPGSVDHMKATIY 319
+ R+ + W L++ E R Q + Q KS ++Q E A + KA
Sbjct: 1623 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1682
Query: 320 GILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE-----LQRK 374
+ + +E E +R+++ + + +A QGE R++ E LQR+
Sbjct: 1683 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Query: 375 LDEEVKKRQKLEPSQVGLERQLE------EKTEECSRL-----QELLERRKGEAQQSNKE 423
+KRQ+LE + ++E + EE SR ++ LE G ++ +E
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Query: 424 LQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAK-----------EVLLKDLLET 472
++ L ++ + R E + + + V + A E+ LK+
Sbjct: 1803 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1862
Query: 473 RELLEEVLEG----KQRVEEQLRLR----ERELTALKGALKEEVASRDQEVEHV---RQQ 521
E L + E ++R+EEQ E L L+ A E+ + VE R+Q
Sbjct: 1863 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1922
Query: 522 YQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKED 581
+ + L+ S + A A LE E ++ + R E+ E Q +E
Sbjct: 1923 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQLAAEEER 1981
Query: 582 LRATKQELLQLRMEKEE----MEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRT 637
R +E +Q + EE + E++E L+ ++E+AR Q + +L +
Sbjct: 1982 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2041
Query: 638 QEELKELQAERQSQEVAGRHRDRELEKQLAV-------LRVEADRGR----ELEEQNLQL 686
+ K LQAE ++ A + +++EL++ L LR EA+ R E EE +Q
Sbjct: 2042 AAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2100
Query: 687 QKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDE-FRRRILGLEQQ 745
++ Q R+ EEA + K AE +A Q +AA E +E ++E + L Q+
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2160
Query: 746 LKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEA 805
+ + E LR K Q +E E L L + ++ L + L+A EA
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQ-VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219
Query: 806 QRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLL-----DRTVDRLNKELEK 860
R +++ +E ++ +EE L + KA +E + R L D T L +E EK
Sbjct: 2220 ARQRSQVEEELFSVRVQMEE-------LSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2272
Query: 861 IGEDSKQALQQLQAQLED--YKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRL 918
+ + +++A + A E ++ A ++A + A+ E + +RL+ E + L
Sbjct: 2273 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332
Query: 919 RQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQD-DRARQLKGLEEKVSRLETE 977
+Q + +Q + + DKE +AQ+L +E + +R+ + +R RQL+ + + RL+
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLA---EETQGFQRTLEAERQRQLE-MSAEAERLKLR 2388
Query: 978 LDEEKNTVELLTDRVNRGRDQVDQL-----RTELMQERSAR--QDLECDKISLERQNKDL 1030
+ E + R R Q +++ RTEL + Q LE + + + L
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2448
Query: 1031 KTRLASSEGFQKP---SASLSQLES-------QNQLLQERLQAEER---EKTVLQSTNRK 1077
+ +A E ++ A L QL+S Q QLLQE ++ EK L R
Sbjct: 2449 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508
Query: 1078 LERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEE 1137
+E++ +L +DE +++ +RQ + E+E +RL ++A+R E
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQ-------QRQQQQMEQERQRLVASMEEARRRQHE 2561
Query: 1138 QHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEE 1179
E + Q ++ LE+ ++ A E+ E L EE
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2603
Score = 147 bits (370), Expect = 8e-35
Identities = 242/1007 (24%), Positives = 436/1007 (43%), Gaps = 137/1007 (13%)
Query: 270 QDWVLQSFE----EPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREG 325
+ W L +F E +R A L +++ LRD Q+A G D + A RE
Sbjct: 907 RSWSLATFRTLKPEEQRQALHSLELHYQA---FLRDSQDAGGFGPEDRLMAE-----REY 958
Query: 326 SSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGEL--------TRKVEELQRKLDE 377
S S +L+ ++ S + ++ ++ TR V L+ LD+
Sbjct: 959 GSCSH-----HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1013
Query: 378 E--------VKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKR 429
E + ++QK + GL + + + E ++ L E A EL+
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA-APTLRSELELTLG 1072
Query: 430 LLDQGEDLRHGLETQVMELQNKLKHVQGPEP---AKEVLLKDLLETRELLEEVLEGKQRV 486
L+Q L ++ + ++ QG E A E LK+ L E LE +
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKAS 1131
Query: 487 EEQLRLRERELTALKGALKEEVASRDQEVEHVRQQY-QRDTEQLR---RSMQDATQDHAV 542
++LR + AL++E+ + E ++Q++ +RD E R R Q + AV
Sbjct: 1132 LKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV 1191
Query: 543 L---EAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKE--------DLRATKQELLQ 591
L + ++++ L R L R E+++ G W ++ +E D +A +++L Q
Sbjct: 1192 LAQTDVRQRELEQLGRQL-RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1250
Query: 592 LRMEKEEMEEELGEKIEVLQRELEQARASAGDTR-QVEVLKKELLRTQEELKELQAERQS 650
+ EE+E GEK+E QR +Q + D Q+ K +L K+ + + S
Sbjct: 1251 EQALLEEIERH-GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309
Query: 651 QEVAGRHRD-RELEKQLAVL-------------------RVEADRGRELEEQNLQLQKTL 690
+ V + D R +L L R+ + E E+ +++ L
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1369
Query: 691 QQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETR 750
++ RQ E ++AK AE EA L QR E + + +R I QQL+++
Sbjct: 1370 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1429
Query: 751 GLVDGGEAVEARLRDKLQ-RLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGL 809
+A +A ++ + R+E E + + L A++ + G +AL AR EEA+
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489
Query: 810 ARLGQEQQTLNRALEEEGKQR-----EVLRRGKAELE---EQKRLLDRTVDRLNKELEKI 861
+ +E + L R +++E +++ E+ R KAE E E++R L + ++ L + E+
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL-QALEELRLQAEEA 1548
Query: 862 GEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDE---IQRL 918
+QA + Q++ E A+R A+A+ Q+K AS AEKT+ LQ+E + +L
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRS-AEAELQSKR-ASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 919 RQ-----ALQASQAERDTA-------------------RLDKELLAQRLQGLEQEAENKK 954
R+ A Q ++AER RL E +AQ+ + EAE +K
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 955 RSQDDRARQLKGLEEKVSR----LETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQER 1010
+ AR+ EE+ R E EL++++ E + ++ +LR E Q
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 1011 SARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQ-LLQERLQAEEREKT 1069
RQ LE + L+R+ A+++ Q+ A L+++ ++ + LL + +AEE ++
Sbjct: 1727 QQRQLLEEELARLQRE------AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 1070 VLQSTNRKLER---KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEI-ERLD 1125
+ + ++LE + +EL+ + R + K Q L + RQ EAE + E+L
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 1126 G------LRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAE 1166
L+ +A+ ++E+ NE+L+ R+ E R+ AA+
Sbjct: 1841 AIGEATRLKTEAEIALKEKEAENERLR-RLAEDEAFQRRRLEEQAAQ 1886
Score = 143 bits (361), Expect = 9e-34
Identities = 201/875 (22%), Positives = 370/875 (42%), Gaps = 125/875 (14%)
Query: 278 EEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKV 337
EE RS + + + ++ R+ E A ++A R+ E + R++
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAA-----RLRALAEEAKRQRQLAEEDAARQRA 1829
Query: 338 S---LVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLER 394
++ EK+ + + T+A E + E L+R ++E +R++LE +
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889
Query: 395 QLEEKTEECSRLQEL-LERRKG-------EAQQSNKELQNMK------------------ 428
+EE+ + + + LER+KG + +Q +E+ +K
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 429 RLLDQGEDLRHGLETQVMELQNKLKHVQGPE----PAKEVLLKDLLETREL-------LE 477
R+ ED E +E + + E A+E + K L E LE
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 478 EVLEGKQRVEEQLRLRER------------------ELTALKGALKEEVASRDQEVEHVR 519
EV K +VEE RLRER L A + A V ++QE++
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 520 QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNK 579
QQ Q +QLR + A + A EAE ++ A +RE ++ + + + Q +
Sbjct: 2070 QQEQSVLDQLRGEAEAARR--AAEEAEEARVQA-----EREAAQSRRQVEEAERLKQSAE 2122
Query: 580 EDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQE 639
E +A Q ++E E+E + + Q L Q +A+ + + + ++ LR +
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2182
Query: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE 699
++++ + Q H+ L+++L L+ EA E Q Q+++ L +R EE
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT---EAARQRSQVEEELFSVRVQMEE 2239
Query: 700 ASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRR------RILGLEQQLKETRGLV 753
SK K EAE L R + T R QEE ++ ++ R+ Q+ R L
Sbjct: 2240 LSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 754 DGGEA-----VEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRG 808
+ A E L++K+Q ++ + EA Q++E + A+R E + + AQ+
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ- 2356
Query: 809 LARLGQEQQTLNRALEEEGKQR-------EVLRRGKAELEEQKRLLDRTVDRLNKELEKI 861
L +E Q R LE E +++ E L+ AE+ + + R K+ E+I
Sbjct: 2357 ---LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 862 GE---------DSKQALQQ---LQAQLEDYK-EKARREVADAQRQAKDWASEAEKTSGGL 908
GE K L Q +Q Q D+ E+ R +A+ +R+ + EA+ L
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL----L 2469
Query: 909 SRLQDEIQRLRQA--LQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKG 966
+E+Q ++Q LQ +QA + + +K+ L QR + +EQE ++ D + +
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2529
Query: 967 LEEKVSRLETELDEEKN----TVELLTDRVNRGRDQVDQLRTELMQ-ERSARQDLECDKI 1021
L E+ R + ++++E+ ++E R + + V + + EL Q E+ RQ E
Sbjct: 2530 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL--- 2586
Query: 1022 SLERQNKDLKTRLASSEGFQKPSASLSQLESQNQL 1056
L +N+ L+ +L E + + + S+ + +Q+
Sbjct: 2587 -LAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2620
Score = 133 bits (335), Expect = 9e-31
Identities = 177/778 (22%), Positives = 330/778 (42%), Gaps = 101/778 (12%)
Query: 315 KATIYGILREGSSESETSVRRKVSLVLEKM-------QPLVMVSSGSTKAVAGQGELTRK 367
KA I L + S++ + R+ LV + + + ++ + + KA AG+ EL +
Sbjct: 1888 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1947
Query: 368 VEELQRKLDEEVKKRQKLEPSQVGLERQL-----EEKTEECSRLQELLERRKGEAQQSNK 422
+ ++ ++ ++ +++ E + +RQL + E R+Q+ L + A+Q
Sbjct: 1948 LGRIRSNAEDTLRSKEQAE-LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006
Query: 423 ELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEG 482
L+ ++RL + E+ R E E +L+ Q E A++ L E + V +
Sbjct: 2007 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--EAAQKRLQA---EEKAHAFAVQQK 2061
Query: 483 KQRVEEQLRLRERELTALKGALKEEVASRD-QEVEHVRQQYQRDTEQLRRSMQDATQDHA 541
+Q +++ L+ + L L+G + E A R +E E R Q +R+ Q RR +++A +
Sbjct: 2062 EQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119
Query: 542 VLEAERQ---KMSALVRGLQRELEETSEETGHWQ--SMFQKNKEDLRATK---------- 586
E + Q + A L++E E+ + + ++ QK D K
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 587 ------QELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEE 640
QEL LR++ EE + + E LQR +A +A QVE + EE
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Query: 641 LKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEA 700
L +L+A +++ A RD++ ++ L+ EA++ +++ E+ +L Q EA
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRF--LQEEAEKMKQVAEEAARLSVAAQ-------EA 2290
Query: 701 SKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVE 760
++ + +AE + L Q+RA E L+E + E R E ++ + ++
Sbjct: 2291 ARLRQLAEED---LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2347
Query: 761 ARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLN 820
Q+L E Q + L A ++ + ++A L+ R+ E R AR ++ Q
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2407
Query: 821 RALEEEGKQ----------------------------REVLRRGKAELEEQKRLLDRTVD 852
+ EE G++ E LR AELE +K L +
Sbjct: 2408 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2467
Query: 853 RLNKELEKIGE-DSKQALQQLQAQLEDYKEKA----------RREVADAQRQAKDWASEA 901
L + E++ +Q LQ+ QA + + + +E A ++ +D ++A
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527
Query: 902 EKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDD-- 959
++ R Q ++++ RQ L AS E + + E +R Q Q+ E ++R Q++
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587
Query: 960 -----RAR-QLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERS 1011
R R QL+ LEE+ +E + T + GRD +D E E S
Sbjct: 2588 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2645
Score = 111 bits (277), Expect = 5e-24
Identities = 151/762 (19%), Positives = 328/762 (43%), Gaps = 93/762 (12%)
Query: 200 RTRMLPPEQRKRSKSLDSRLPRDTFEERER--------QSTNHWTSSTKYDNHVGTSKQP 251
R R L E+ +R + + R+ + E E + + + + +
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2030
Query: 252 AQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQ-DPTMLQFKSTPDLLRDQQEAAPPGS 310
++ L ++ R + +F ++ + T+ Q +S D LR + EAA +
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090
Query: 311 VDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE 370
E + E+ R+ + +++ + + + + + E+
Sbjct: 2091 -------------EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 371 LQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRL 430
L+++ ++E +R + E + + ++ + + E+ + E R+K + +Q EL ++
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ---ELTTLRLQ 2194
Query: 431 LDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQL 490
L++ + ++ L+ ++ L+ + E ++L R +EE+ + K R+E +
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQVE---EELFSVRVQMEELSKLKARIEAEN 2251
Query: 491 R---LRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAER 547
R LR+++ T + L+EE Q E + +L + Q+A + + E +
Sbjct: 2252 RALILRDKDNT--QRFLQEEAEKMKQVAE--------EAARLSVAAQEAARLRQLAEEDL 2301
Query: 548 QKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKI 607
+ AL + +E + +E ++ + ++ +++ +L+ +KE+M ++L E+
Sbjct: 2302 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2361
Query: 608 EVLQRELEQARAS----AGDTRQVEVLKKELLRTQEELKE--LQAERQSQEVAGRHRDRE 661
+ QR LE R + + ++++ E+ R Q +E + +Q++E+ + E
Sbjct: 2362 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2421
Query: 662 LEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAV 721
L Q V V+ LE Q Q ++LR+ E + K + EA +L + +
Sbjct: 2422 LATQEKVTLVQT-----LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 722 ETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEAL 781
+T +E Q L+ET+ L + + L + + +E EK +LE+
Sbjct: 2477 QTVQQE----------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520
Query: 782 NASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQR----EVLRRGK 837
++E + A R EE QR ++ QE+Q L ++EE +++ E +RR +
Sbjct: 2521 ----QDEVAKAQQLR------EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570
Query: 838 AELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQ-----R 892
EL++ ++ + + L +E +++ E + +Q +A L +E +VA + R
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2630
Query: 893 QAKDW---ASEAEKTSGGLSRLQDEIQRLRQA--LQASQAER 929
A D +E E + GL R + QRL++A L A + +R
Sbjct: 2631 DALDGPAAEAEPEHSFDGLRR-KVSAQRLQEAGILSAEELQR 2671
Score = 103 bits (256), Expect = 1e-21
Identities = 185/831 (22%), Positives = 354/831 (42%), Gaps = 128/831 (15%)
Query: 397 EEKTEECSR-LQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHV 455
E + CS Q+LL+ + AQ+ ++ +R + + +D+R LE ++L+
Sbjct: 955 EREYGSCSHHYQQLLQSLEQGAQEESR----CQRCISELKDIRLQLEACETRTVHRLRLP 1010
Query: 456 QGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEV 515
EPA+E + + E ++ EV EG + +L ++ AL E
Sbjct: 1011 LDKEPARECAQR-IAEQQKAQAEV-EGLGKGVARLSAEAEKVLALP------------EP 1056
Query: 516 EHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQ--RELEETSEETGHWQS 573
+ + E ++ A+ + + +S ++RG Q E+ EE
Sbjct: 1057 SPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1116
Query: 574 MFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKE 633
+L ATK L +LR + E + + L+ EL A+ E
Sbjct: 1117 AVPATLPELEATKASLKKLRAQAEAQQPTF----DALRDELRGAQEVG-----------E 1161
Query: 634 LLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQ---KTL 690
L+ + ++++ ER + VA + LE+ AVL R RELE+ QL+ ++
Sbjct: 1162 RLQQRHGERDVEVERWRERVA-----QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1216
Query: 691 QQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETR 750
L ++A + + +A Q AV LR+ Q +E R +E+ + +
Sbjct: 1217 DPLGAWLQDARRRQEQIQAMPLADSQ---AVREQLRQEQALLEEIERHGEKVEECQRFAK 1273
Query: 751 GLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQE---EEGSLAAAKRALEARLEEAQR 807
++ ++D +L K QLE + +++ + GS + + ++ R ++
Sbjct: 1274 QYINA-------IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE- 1325
Query: 808 GLARLGQE-----QQTLNRALEEE-------GKQREVLRRGKAELEEQKRLLDR------ 849
L L + +TL R EEE ++RE L +A LE+Q++L +
Sbjct: 1326 -LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384
Query: 850 TVDRLNKEL-----------EKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWA 898
+R KEL E+ D++Q + +Q +L+ ++ + E+ QAK A
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI-----QAK--A 1437
Query: 899 SEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELL--------AQRLQGLEQEA 950
+AE R+++EI+ +R L+A++ +R A + + L AQ+ Q E+
Sbjct: 1438 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497
Query: 951 ENKKRSQDDRARQLKGLEEKVSRLETELD---EEKNTVELLTDRVNRGRDQVDQLR-TEL 1006
+++ QD+ R+ + E SR++ E + E++ ++ L + + + +LR E+
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1557
Query: 1007 MQERSARQDLECDKISLERQNKDLKTRLAS-----SEGFQKPSASLSQLESQNQLLQERL 1061
+ R + LE + S E + + + A Q+ +++QL + + R
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRA 1614
Query: 1062 QAEEREKTVLQSTNRKLER---KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAE 1118
Q + + + R+LER K E ++++ + + V QK SL ++Q +EAE
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANE-ALRLRLQAEEVAQQK---SLAQAEAEKQKEEAE 1670
Query: 1119 EEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESAL 1169
E R R KA+ + Q E+ EQ + + L + + ++ R AAE L
Sbjct: 1671 REARR----RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ--RLAAEQEL 1715
Score = 86.3 bits (212), Expect = 2e-16
Identities = 160/694 (23%), Positives = 301/694 (43%), Gaps = 78/694 (11%)
Query: 520 QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQS---MFQ 576
Q +RD QL RS AT E +RQ + +L Q L ++ + G M +
Sbjct: 897 QSLRRDV-QLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE 955
Query: 577 KNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLR 636
+ Q+LLQ +E+ EE ++ +++ + + A +TR V L+ L
Sbjct: 956 REYGSCSHHYQQLLQ-SLEQGAQEESRCQRCISELKDI-RLQLEACETRTVHRLRLPL-- 1011
Query: 637 TQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQD 696
+E +E A+R +++ + L K +A L EA++ L E + LR +
Sbjct: 1012 DKEPAREC-AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSE 1066
Query: 697 CE-EASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGL--- 752
E K + V A L ++ + +R TQ + R E+QLKE + +
Sbjct: 1067 LELTLGKLEQVRSLSAIYL-EKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPAT 1121
Query: 753 VDGGEAVEARLRDKLQRLEAEKQQ-----LEEALNASQEEEGSLAAAKRALEARLEEAQR 807
+ EA +A L K R +AE QQ L + L +QE L + +E +
Sbjct: 1122 LPELEATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1179
Query: 808 GLARLGQEQQTL-------NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEK 860
+A+L + Q + R LE+ G+Q R L + R +++
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1239
Query: 861 IGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQ 920
+ ++ L+Q QA LE+ E+ +V + QR AK + + + L + +++ +
Sbjct: 1240 DSQAVREQLRQEQALLEEI-ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-- 1296
Query: 921 ALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETE--L 978
AS A++ + E + Q L ++ +K + E + R+E E L
Sbjct: 1297 ---ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT---SQYIKFISETLRRMEEEERL 1350
Query: 979 DEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE 1038
E++ E R+++ ++ L ++R + K ER+ K+L+ R+ E
Sbjct: 1351 AEQQRAEE---------RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM-QEE 1400
Query: 1039 GFQKPSASLSQLESQNQLLQERL-----------QAEEREKTVLQSTNRKLERKVKELSI 1087
++ A++ + Q + +QE L QA+ R+ + + ++E +++ + +
Sbjct: 1401 VVRREEAAVDA-QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459
Query: 1088 QIE-DERQHVNDQKDQLSLRVKA--LKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQ 1144
Q+E ERQ + + +LR +A + Q +A+EE ER LR++ Q E + + + +
Sbjct: 1460 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER---LRRQVQDESQRKRQAEVE 1516
Query: 1145 LQARIKSLEKDSWRKASRSAAESALKNEGLSSDE 1178
L +R+K+ E ++ R+ R A AL+ L ++E
Sbjct: 1517 LASRVKA-EAEAAREKQR--ALQALEELRLQAEE 1547
Score = 62.4 bits (150), Expect = 3e-09
Identities = 86/427 (20%), Positives = 178/427 (41%), Gaps = 27/427 (6%)
Query: 285 QDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKM 344
+D T + + ++ E A SV +A L E + ++ K ++ EKM
Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK--MLKEKM 2316
Query: 345 QPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTE--- 401
Q + + +A Q + E+ +R +++ + Q+L G +R LE + +
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 402 ECSRLQELLERRKGEAQQSNKELQ-NMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEP 460
E S E L+ R E ++ + + +R Q E++ L + Q K+ VQ E
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 461 AKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHV-- 518
++ D RE + E+ K++++++ +L + + ++ +E++ Q ++
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 519 -----RQQYQRDTEQLRRSMQDATQDHAV----LEAERQKMSALVRGLQRELEETSEETG 569
Q +R EQ + ++ QD L E+Q+ + ++ L + EE
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556
Query: 570 HWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKI-EVLQRELEQARASAGDTRQVE 628
Q ++ + Q+L Q R ++EE+ E +++ E LQ EQ RA+ + +V
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616
Query: 629 VLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQK 688
+ +T ++ + + E H L ++++ R L+E + +
Sbjct: 2617 ASQVAATKTLPNGRD-ALDGPAAEAEPEHSFDGLRRKVSAQR--------LQEAGILSAE 2667
Query: 689 TLQQLRQ 695
LQ+L Q
Sbjct: 2668 ELQRLAQ 2674
Score = 48.1 bits (113), Expect = 5e-05
Identities = 126/582 (21%), Positives = 230/582 (39%), Gaps = 101/582 (17%)
Query: 455 VQGPEPAKEVLL---KDLLETRELLEEVLEGKQRVEEQLRLRE-RELTAL--------KG 502
V P+P ++ ++ L + + +V +G + E QLR +E REL L
Sbjct: 241 VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTA 300
Query: 503 ALKEE-VASRDQEVEHVRQQYQRDTEQ--------------LRRSMQDATQ--------D 539
A +E S +E+E + Q+ + E + +S++ A Q
Sbjct: 301 AFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG 360
Query: 540 HAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEM 599
+ L+ E++ V L+RE + SE E L ++ + +L+ME
Sbjct: 361 YHPLDVEKEWGKLHVAILEREKQLRSEF------------ERLECLQRIVTKLQMEAGLC 408
Query: 600 EEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRD 659
EE+L + +LQ ++ A R EV +++L + ++ L + Q+ + GRH
Sbjct: 409 EEQLNQADALLQSDVRLLAAGKVPQRAGEV-ERDLDKADSMIRLLFNDVQTLK-DGRHPQ 466
Query: 660 RELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRA 719
E + V R+ + L +T LR A+ A VA+ + +R
Sbjct: 467 GE-QMYRRVYRLH---------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPE 516
Query: 720 AVETTLRETQ------EEND------EFRRRILGLEQQLKETRGLVDGGEAVEARLR--- 764
++TLR Q EEN E+ + +E QL RGL E A++
Sbjct: 517 LEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR 576
Query: 765 -DKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRAL 823
D+ Q A + + L + L + +A LE +A +E LN
Sbjct: 577 SDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 636
Query: 824 EEE--------------GKQREVLRRGKAELEEQK-RLLDRTVDRLNKELEKIGEDSKQA 868
EEE K+ + EL+E+K + L DRL +E ++
Sbjct: 637 EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRE----DHPARPT 692
Query: 869 LQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAE 928
++ QA L+ + + K+ A+ + S + + ++Q+L++AL+ +
Sbjct: 693 VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQKLQEALRRKYS- 750
Query: 929 RDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEK 970
D+ RL+ L Q+A+++K ++ L GL ++
Sbjct: 751 -----CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 787
Score = 35.8 bits (81), Expect = 0.25
Identities = 117/542 (21%), Positives = 215/542 (39%), Gaps = 92/542 (16%)
Query: 626 QVEVLKKELLRTQE-ELKELQAER-------QSQEVAGR---------HRDRELEKQLAV 668
++E+L + L+ +E EL +A++ QS E A + + ++EK+
Sbjct: 313 EIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGK 372
Query: 669 LRV---EADRGRELEEQNLQ-LQKTLQQLRQD---CEEA-SKAKMVAEAEATVLG----- 715
L V E ++ E + L+ LQ+ + +L+ + CEE ++A + +++ +L
Sbjct: 373 LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVP 432
Query: 716 QRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQ 775
QR VE L ++ D R + Q LK+ R GE + R+ +RL A +
Sbjct: 433 QRAGEVERDL----DKADSMIRLLFNDVQTLKDGRH--PQGEQMYRRVYRLHERLVAIRT 486
Query: 776 QLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRR 835
+ L A G A A + + L+ QR R E TL L+
Sbjct: 487 EYNLRLKA-----GVAAPATQVAQVTLQSVQR---RPELEDSTLR-----------YLQD 527
Query: 836 GKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAK 895
A +EE + +D ++ + S + L Q +E+++ K R +D + Q
Sbjct: 528 LLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ---SIEEFRAKIERARSD-EGQLS 583
Query: 896 DWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGL-EQEAENKK 954
A + L RL + +L + +A ++ + L L E+E E
Sbjct: 584 PATRGAYRDC--LGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVG 641
Query: 955 RSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQ 1014
DR + +E S L EL+ ++ ++ L + +R L ++ AR
Sbjct: 642 FDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDR----------LLREDHPARP 691
Query: 1015 DLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQST 1074
+E + +L+ Q + E K +A+ Q S + +AE + + + ++
Sbjct: 692 TVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVR------EAEGQLQKLQEAL 745
Query: 1075 NRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQRE 1134
RK ++ED Q D+K+QL+ E L GL K+A+
Sbjct: 746 RRKYSCDRSATVTRLEDLLQDAQDEKEQLN--------------EYKGHLSGLAKRAKAV 791
Query: 1135 VE 1136
V+
Sbjct: 792 VQ 793
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 164 bits (415), Expect = 5e-40
Identities = 245/1062 (23%), Positives = 442/1062 (41%), Gaps = 115/1062 (10%)
Query: 207 EQRKRSKSLDSRLPRDTFEERERQSTNHWTSSTKYDNHVGTSK------QPAQSQNLSPL 260
E +RS + + R +F E+ Q + + HV ++ + AQ Q +
Sbjct: 1536 ETAQRSAEAELQSKRASFAEKTAQ-----LERSLQEEHVAVAQLREEAERRAQQQAEAER 1590
Query: 261 SGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQ-EAAPPGSVDHMKATIY 319
+ R+ + W L++ E R Q + Q KS ++Q E A + KA
Sbjct: 1591 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1650
Query: 320 GILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE-----LQRK 374
+ + +E E +R+++ + + +A QGE R++ E LQR+
Sbjct: 1651 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1710
Query: 375 LDEEVKKRQKLEPSQVGLERQLE------EKTEECSRL-----QELLERRKGEAQQSNKE 423
+KRQ+LE + ++E + EE SR ++ LE G ++ +E
Sbjct: 1711 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1770
Query: 424 LQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAK-----------EVLLKDLLET 472
++ L ++ + R E + + + V + A E+ LK+
Sbjct: 1771 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1830
Query: 473 RELLEEVLEG----KQRVEEQLRLR----ERELTALKGALKEEVASRDQEVEHV---RQQ 521
E L + E ++R+EEQ E L L+ A E+ + VE R+Q
Sbjct: 1831 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1890
Query: 522 YQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKED 581
+ + L+ S + A A LE E ++ + R E+ E Q +E
Sbjct: 1891 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQLAAEEER 1949
Query: 582 LRATKQELLQLRMEKEE----MEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRT 637
R +E +Q + EE + E++E L+ ++E+AR Q + +L +
Sbjct: 1950 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2009
Query: 638 QEELKELQAERQSQEVAGRHRDRELEKQLAV-------LRVEADRGR----ELEEQNLQL 686
+ K LQAE ++ A + +++EL++ L LR EA+ R E EE +Q
Sbjct: 2010 AAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2068
Query: 687 QKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDE-FRRRILGLEQQ 745
++ Q R+ EEA + K AE +A Q +AA E +E ++E + L Q+
Sbjct: 2069 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2128
Query: 746 LKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEA 805
+ + E LR K Q +E E L L + ++ L + L+A EA
Sbjct: 2129 QAADAEMEKHKKFAEQTLRQKAQ-VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2187
Query: 806 QRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLL-----DRTVDRLNKELEK 860
R +++ +E ++ +EE L + KA +E + R L D T L +E EK
Sbjct: 2188 ARQRSQVEEELFSVRVQMEE-------LSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2240
Query: 861 IGEDSKQALQQLQAQLED--YKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRL 918
+ + +++A + A E ++ A ++A + A+ E + +RL+ E + L
Sbjct: 2241 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2300
Query: 919 RQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQD-DRARQLKGLEEKVSRLETE 977
+Q + +Q + + DKE +AQ+L +E + +R+ + +R RQL+ + + RL+
Sbjct: 2301 QQQKELAQEQARRLQEDKEQMAQQLA---EETQGFQRTLEAERQRQLE-MSAEAERLKLR 2356
Query: 978 LDEEKNTVELLTDRVNRGRDQVDQL-----RTELMQERSAR--QDLECDKISLERQNKDL 1030
+ E + R R Q +++ RTEL + Q LE + + + L
Sbjct: 2357 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2416
Query: 1031 KTRLASSEGFQKP---SASLSQLES-------QNQLLQERLQAEER---EKTVLQSTNRK 1077
+ +A E ++ A L QL+S Q QLLQE ++ EK L R
Sbjct: 2417 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2476
Query: 1078 LERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEE 1137
+E++ +L +DE +++ +RQ + E+E +RL ++A+R E
Sbjct: 2477 IEQEKAKLEQLFQDEVAKAQQLREEQ-------QRQQQQMEQERQRLVASMEEARRRQHE 2529
Query: 1138 QHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEE 1179
E + Q ++ LE+ ++ A E+ E L EE
Sbjct: 2530 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2571
Score = 147 bits (370), Expect = 8e-35
Identities = 242/1007 (24%), Positives = 436/1007 (43%), Gaps = 137/1007 (13%)
Query: 270 QDWVLQSFE----EPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREG 325
+ W L +F E +R A L +++ LRD Q+A G D + A RE
Sbjct: 875 RSWSLATFRTLKPEEQRQALHSLELHYQA---FLRDSQDAGGFGPEDRLMAE-----REY 926
Query: 326 SSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGEL--------TRKVEELQRKLDE 377
S S +L+ ++ S + ++ ++ TR V L+ LD+
Sbjct: 927 GSCSH-----HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 981
Query: 378 E--------VKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKR 429
E + ++QK + GL + + + E ++ L E A EL+
Sbjct: 982 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA-APTLRSELELTLG 1040
Query: 430 LLDQGEDLRHGLETQVMELQNKLKHVQGPEP---AKEVLLKDLLETRELLEEVLEGKQRV 486
L+Q L ++ + ++ QG E A E LK+ L E LE +
Sbjct: 1041 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKAS 1099
Query: 487 EEQLRLRERELTALKGALKEEVASRDQEVEHVRQQY-QRDTEQLR---RSMQDATQDHAV 542
++LR + AL++E+ + E ++Q++ +RD E R R Q + AV
Sbjct: 1100 LKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV 1159
Query: 543 L---EAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKE--------DLRATKQELLQ 591
L + ++++ L R L R E+++ G W ++ +E D +A +++L Q
Sbjct: 1160 LAQTDVRQRELEQLGRQL-RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1218
Query: 592 LRMEKEEMEEELGEKIEVLQRELEQARASAGDTR-QVEVLKKELLRTQEELKELQAERQS 650
+ EE+E GEK+E QR +Q + D Q+ K +L K+ + + S
Sbjct: 1219 EQALLEEIERH-GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1277
Query: 651 QEVAGRHRD-RELEKQLAVL-------------------RVEADRGRELEEQNLQLQKTL 690
+ V + D R +L L R+ + E E+ +++ L
Sbjct: 1278 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1337
Query: 691 QQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETR 750
++ RQ E ++AK AE EA L QR E + + +R I QQL+++
Sbjct: 1338 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1397
Query: 751 GLVDGGEAVEARLRDKLQ-RLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGL 809
+A +A ++ + R+E E + + L A++ + G +AL AR EEA+
Sbjct: 1398 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1457
Query: 810 ARLGQEQQTLNRALEEEGKQR-----EVLRRGKAELE---EQKRLLDRTVDRLNKELEKI 861
+ +E + L R +++E +++ E+ R KAE E E++R L + ++ L + E+
Sbjct: 1458 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL-QALEELRLQAEEA 1516
Query: 862 GEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDE---IQRL 918
+QA + Q++ E A+R A+A+ Q+K AS AEKT+ LQ+E + +L
Sbjct: 1517 ERRLRQAEVERARQVQVALETAQRS-AEAELQSKR-ASFAEKTAQLERSLQEEHVAVAQL 1574
Query: 919 RQ-----ALQASQAERDTA-------------------RLDKELLAQRLQGLEQEAENKK 954
R+ A Q ++AER RL E +AQ+ + EAE +K
Sbjct: 1575 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1634
Query: 955 RSQDDRARQLKGLEEKVSR----LETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQER 1010
+ AR+ EE+ R E EL++++ E + ++ +LR E Q
Sbjct: 1635 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1694
Query: 1011 SARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQ-LLQERLQAEEREKT 1069
RQ LE + L+R+ A+++ Q+ A L+++ ++ + LL + +AEE ++
Sbjct: 1695 QQRQLLEEELARLQRE------AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1748
Query: 1070 VLQSTNRKLER---KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEI-ERLD 1125
+ + ++LE + +EL+ + R + K Q L + RQ EAE + E+L
Sbjct: 1749 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1808
Query: 1126 G------LRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAE 1166
L+ +A+ ++E+ NE+L+ R+ E R+ AA+
Sbjct: 1809 AIGEATRLKTEAEIALKEKEAENERLR-RLAEDEAFQRRRLEEQAAQ 1854
Score = 143 bits (361), Expect = 9e-34
Identities = 201/875 (22%), Positives = 370/875 (42%), Gaps = 125/875 (14%)
Query: 278 EEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKV 337
EE RS + + + ++ R+ E A ++A R+ E + R++
Sbjct: 1743 EEESRSTSEKSKQRLEAEAGRFRELAEEAA-----RLRALAEEAKRQRQLAEEDAARQRA 1797
Query: 338 S---LVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLER 394
++ EK+ + + T+A E + E L+R ++E +R++LE +
Sbjct: 1798 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1857
Query: 395 QLEEKTEECSRLQEL-LERRKG-------EAQQSNKELQNMK------------------ 428
+EE+ + + + LER+KG + +Q +E+ +K
Sbjct: 1858 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1917
Query: 429 RLLDQGEDLRHGLETQVMELQNKLKHVQGPE----PAKEVLLKDLLETREL-------LE 477
R+ ED E +E + + E A+E + K L E LE
Sbjct: 1918 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1977
Query: 478 EVLEGKQRVEEQLRLRER------------------ELTALKGALKEEVASRDQEVEHVR 519
EV K +VEE RLRER L A + A V ++QE++
Sbjct: 1978 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2037
Query: 520 QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNK 579
QQ Q +QLR + A + A EAE ++ A +RE ++ + + + Q +
Sbjct: 2038 QQEQSVLDQLRGEAEAARR--AAEEAEEARVQA-----EREAAQSRRQVEEAERLKQSAE 2090
Query: 580 EDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQE 639
E +A Q ++E E+E + + Q L Q +A+ + + + ++ LR +
Sbjct: 2091 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2150
Query: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE 699
++++ + Q H+ L+++L L+ EA E Q Q+++ L +R EE
Sbjct: 2151 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT---EAARQRSQVEEELFSVRVQMEE 2207
Query: 700 ASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRR------RILGLEQQLKETRGLV 753
SK K EAE L R + T R QEE ++ ++ R+ Q+ R L
Sbjct: 2208 LSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2265
Query: 754 DGGEA-----VEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRG 808
+ A E L++K+Q ++ + EA Q++E + A+R E + + AQ+
Sbjct: 2266 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ- 2324
Query: 809 LARLGQEQQTLNRALEEEGKQR-------EVLRRGKAELEEQKRLLDRTVDRLNKELEKI 861
L +E Q R LE E +++ E L+ AE+ + + R K+ E+I
Sbjct: 2325 ---LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2381
Query: 862 GE---------DSKQALQQ---LQAQLEDYK-EKARREVADAQRQAKDWASEAEKTSGGL 908
GE K L Q +Q Q D+ E+ R +A+ +R+ + EA+ L
Sbjct: 2382 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL----L 2437
Query: 909 SRLQDEIQRLRQA--LQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKG 966
+E+Q ++Q LQ +QA + + +K+ L QR + +EQE ++ D + +
Sbjct: 2438 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2497
Query: 967 LEEKVSRLETELDEEKN----TVELLTDRVNRGRDQVDQLRTELMQ-ERSARQDLECDKI 1021
L E+ R + ++++E+ ++E R + + V + + EL Q E+ RQ E
Sbjct: 2498 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL--- 2554
Query: 1022 SLERQNKDLKTRLASSEGFQKPSASLSQLESQNQL 1056
L +N+ L+ +L E + + + S+ + +Q+
Sbjct: 2555 -LAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2588
Score = 133 bits (335), Expect = 9e-31
Identities = 177/778 (22%), Positives = 330/778 (42%), Gaps = 101/778 (12%)
Query: 315 KATIYGILREGSSESETSVRRKVSLVLEKM-------QPLVMVSSGSTKAVAGQGELTRK 367
KA I L + S++ + R+ LV + + + ++ + + KA AG+ EL +
Sbjct: 1856 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1915
Query: 368 VEELQRKLDEEVKKRQKLEPSQVGLERQL-----EEKTEECSRLQELLERRKGEAQQSNK 422
+ ++ ++ ++ +++ E + +RQL + E R+Q+ L + A+Q
Sbjct: 1916 LGRIRSNAEDTLRSKEQAE-LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1974
Query: 423 ELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEG 482
L+ ++RL + E+ R E E +L+ Q E A++ L E + V +
Sbjct: 1975 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--EAAQKRLQA---EEKAHAFAVQQK 2029
Query: 483 KQRVEEQLRLRERELTALKGALKEEVASRD-QEVEHVRQQYQRDTEQLRRSMQDATQDHA 541
+Q +++ L+ + L L+G + E A R +E E R Q +R+ Q RR +++A +
Sbjct: 2030 EQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2087
Query: 542 VLEAERQ---KMSALVRGLQRELEETSEETGHWQ--SMFQKNKEDLRATK---------- 586
E + Q + A L++E E+ + + ++ QK D K
Sbjct: 2088 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2147
Query: 587 ------QELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEE 640
QEL LR++ EE + + E LQR +A +A QVE + EE
Sbjct: 2148 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207
Query: 641 LKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEA 700
L +L+A +++ A RD++ ++ L+ EA++ +++ E+ +L Q EA
Sbjct: 2208 LSKLKARIEAENRALILRDKDNTQRF--LQEEAEKMKQVAEEAARLSVAAQ-------EA 2258
Query: 701 SKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVE 760
++ + +AE + L Q+RA E L+E + E R E ++ + ++
Sbjct: 2259 ARLRQLAEED---LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2315
Query: 761 ARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLN 820
Q+L E Q + L A ++ + ++A L+ R+ E R AR ++ Q
Sbjct: 2316 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2375
Query: 821 RALEEEGKQ----------------------------REVLRRGKAELEEQKRLLDRTVD 852
+ EE G++ E LR AELE +K L +
Sbjct: 2376 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2435
Query: 853 RLNKELEKIGE-DSKQALQQLQAQLEDYKEKA----------RREVADAQRQAKDWASEA 901
L + E++ +Q LQ+ QA + + + +E A ++ +D ++A
Sbjct: 2436 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2495
Query: 902 EKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDD-- 959
++ R Q ++++ RQ L AS E + + E +R Q Q+ E ++R Q++
Sbjct: 2496 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2555
Query: 960 -----RAR-QLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERS 1011
R R QL+ LEE+ +E + T + GRD +D E E S
Sbjct: 2556 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2613
Score = 111 bits (277), Expect = 5e-24
Identities = 151/762 (19%), Positives = 328/762 (43%), Gaps = 93/762 (12%)
Query: 200 RTRMLPPEQRKRSKSLDSRLPRDTFEERER--------QSTNHWTSSTKYDNHVGTSKQP 251
R R L E+ +R + + R+ + E E + + + + +
Sbjct: 1939 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 1998
Query: 252 AQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQ-DPTMLQFKSTPDLLRDQQEAAPPGS 310
++ L ++ R + +F ++ + T+ Q +S D LR + EAA +
Sbjct: 1999 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2058
Query: 311 VDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE 370
E + E+ R+ + +++ + + + + + E+
Sbjct: 2059 -------------EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2105
Query: 371 LQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRL 430
L+++ ++E +R + E + + ++ + + E+ + E R+K + +Q EL ++
Sbjct: 2106 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ---ELTTLRLQ 2162
Query: 431 LDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQL 490
L++ + ++ L+ ++ L+ + E ++L R +EE+ + K R+E +
Sbjct: 2163 LEETDHQKNLLDEELQRLKAEATEAARQRSQVE---EELFSVRVQMEELSKLKARIEAEN 2219
Query: 491 R---LRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAER 547
R LR+++ T + L+EE Q E + +L + Q+A + + E +
Sbjct: 2220 RALILRDKDNT--QRFLQEEAEKMKQVAE--------EAARLSVAAQEAARLRQLAEEDL 2269
Query: 548 QKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKI 607
+ AL + +E + +E ++ + ++ +++ +L+ +KE+M ++L E+
Sbjct: 2270 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2329
Query: 608 EVLQRELEQARAS----AGDTRQVEVLKKELLRTQEELKE--LQAERQSQEVAGRHRDRE 661
+ QR LE R + + ++++ E+ R Q +E + +Q++E+ + E
Sbjct: 2330 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2389
Query: 662 LEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAV 721
L Q V V+ LE Q Q ++LR+ E + K + EA +L + +
Sbjct: 2390 LATQEKVTLVQT-----LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2444
Query: 722 ETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEAL 781
+T +E Q L+ET+ L + + L + + +E EK +LE+
Sbjct: 2445 QTVQQE----------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2488
Query: 782 NASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQR----EVLRRGK 837
++E + A R EE QR ++ QE+Q L ++EE +++ E +RR +
Sbjct: 2489 ----QDEVAKAQQLR------EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2538
Query: 838 AELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQ-----R 892
EL++ ++ + + L +E +++ E + +Q +A L +E +VA + R
Sbjct: 2539 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2598
Query: 893 QAKDW---ASEAEKTSGGLSRLQDEIQRLRQA--LQASQAER 929
A D +E E + GL R + QRL++A L A + +R
Sbjct: 2599 DALDGPAAEAEPEHSFDGLRR-KVSAQRLQEAGILSAEELQR 2639
Score = 103 bits (256), Expect = 1e-21
Identities = 185/831 (22%), Positives = 354/831 (42%), Gaps = 128/831 (15%)
Query: 397 EEKTEECSR-LQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHV 455
E + CS Q+LL+ + AQ+ ++ +R + + +D+R LE ++L+
Sbjct: 923 EREYGSCSHHYQQLLQSLEQGAQEESR----CQRCISELKDIRLQLEACETRTVHRLRLP 978
Query: 456 QGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEV 515
EPA+E + + E ++ EV EG + +L ++ AL E
Sbjct: 979 LDKEPARECAQR-IAEQQKAQAEV-EGLGKGVARLSAEAEKVLALP------------EP 1024
Query: 516 EHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQ--RELEETSEETGHWQS 573
+ + E ++ A+ + + +S ++RG Q E+ EE
Sbjct: 1025 SPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1084
Query: 574 MFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKE 633
+L ATK L +LR + E + + L+ EL A+ E
Sbjct: 1085 AVPATLPELEATKASLKKLRAQAEAQQPTF----DALRDELRGAQEVG-----------E 1129
Query: 634 LLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQ---KTL 690
L+ + ++++ ER + VA + LE+ AVL R RELE+ QL+ ++
Sbjct: 1130 RLQQRHGERDVEVERWRERVA-----QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1184
Query: 691 QQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETR 750
L ++A + + +A Q AV LR+ Q +E R +E+ + +
Sbjct: 1185 DPLGAWLQDARRRQEQIQAMPLADSQ---AVREQLRQEQALLEEIERHGEKVEECQRFAK 1241
Query: 751 GLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQE---EEGSLAAAKRALEARLEEAQR 807
++ ++D +L K QLE + +++ + GS + + ++ R ++
Sbjct: 1242 QYINA-------IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE- 1293
Query: 808 GLARLGQE-----QQTLNRALEEE-------GKQREVLRRGKAELEEQKRLLDR------ 849
L L + +TL R EEE ++RE L +A LE+Q++L +
Sbjct: 1294 -LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1352
Query: 850 TVDRLNKEL-----------EKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWA 898
+R KEL E+ D++Q + +Q +L+ ++ + E+ QAK A
Sbjct: 1353 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI-----QAK--A 1405
Query: 899 SEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELL--------AQRLQGLEQEA 950
+AE R+++EI+ +R L+A++ +R A + + L AQ+ Q E+
Sbjct: 1406 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1465
Query: 951 ENKKRSQDDRARQLKGLEEKVSRLETELD---EEKNTVELLTDRVNRGRDQVDQLR-TEL 1006
+++ QD+ R+ + E SR++ E + E++ ++ L + + + +LR E+
Sbjct: 1466 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1525
Query: 1007 MQERSARQDLECDKISLERQNKDLKTRLAS-----SEGFQKPSASLSQLESQNQLLQERL 1061
+ R + LE + S E + + + A Q+ +++QL + + R
Sbjct: 1526 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRA 1582
Query: 1062 QAEEREKTVLQSTNRKLER---KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAE 1118
Q + + + R+LER K E ++++ + + V QK SL ++Q +EAE
Sbjct: 1583 QQQAEAERAREEAERELERWQLKANE-ALRLRLQAEEVAQQK---SLAQAEAEKQKEEAE 1638
Query: 1119 EEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESAL 1169
E R R KA+ + Q E+ EQ + + L + + ++ R AAE L
Sbjct: 1639 REARR----RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ--RLAAEQEL 1683
Score = 86.3 bits (212), Expect = 2e-16
Identities = 160/694 (23%), Positives = 301/694 (43%), Gaps = 78/694 (11%)
Query: 520 QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQS---MFQ 576
Q +RD QL RS AT E +RQ + +L Q L ++ + G M +
Sbjct: 865 QSLRRDV-QLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE 923
Query: 577 KNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLR 636
+ Q+LLQ +E+ EE ++ +++ + + A +TR V L+ L
Sbjct: 924 REYGSCSHHYQQLLQ-SLEQGAQEESRCQRCISELKDI-RLQLEACETRTVHRLRLPL-- 979
Query: 637 TQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQD 696
+E +E A+R +++ + L K +A L EA++ L E + LR +
Sbjct: 980 DKEPAREC-AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSE 1034
Query: 697 CE-EASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGL--- 752
E K + V A L ++ + +R TQ + R E+QLKE + +
Sbjct: 1035 LELTLGKLEQVRSLSAIYL-EKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPAT 1089
Query: 753 VDGGEAVEARLRDKLQRLEAEKQQ-----LEEALNASQEEEGSLAAAKRALEARLEEAQR 807
+ EA +A L K R +AE QQ L + L +QE L + +E +
Sbjct: 1090 LPELEATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1147
Query: 808 GLARLGQEQQTL-------NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEK 860
+A+L + Q + R LE+ G+Q R L + R +++
Sbjct: 1148 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1207
Query: 861 IGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQ 920
+ ++ L+Q QA LE+ E+ +V + QR AK + + + L + +++ +
Sbjct: 1208 DSQAVREQLRQEQALLEEI-ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-- 1264
Query: 921 ALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETE--L 978
AS A++ + E + Q L ++ +K + E + R+E E L
Sbjct: 1265 ---ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT---SQYIKFISETLRRMEEEERL 1318
Query: 979 DEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE 1038
E++ E R+++ ++ L ++R + K ER+ K+L+ R+ E
Sbjct: 1319 AEQQRAEE---------RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM-QEE 1368
Query: 1039 GFQKPSASLSQLESQNQLLQERL-----------QAEEREKTVLQSTNRKLERKVKELSI 1087
++ A++ + Q + +QE L QA+ R+ + + ++E +++ + +
Sbjct: 1369 VVRREEAAVDA-QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1427
Query: 1088 QIE-DERQHVNDQKDQLSLRVKA--LKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQ 1144
Q+E ERQ + + +LR +A + Q +A+EE ER LR++ Q E + + + +
Sbjct: 1428 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER---LRRQVQDESQRKRQAEVE 1484
Query: 1145 LQARIKSLEKDSWRKASRSAAESALKNEGLSSDE 1178
L +R+K+ E ++ R+ R A AL+ L ++E
Sbjct: 1485 LASRVKA-EAEAAREKQR--ALQALEELRLQAEE 1515
Score = 62.4 bits (150), Expect = 3e-09
Identities = 86/427 (20%), Positives = 178/427 (41%), Gaps = 27/427 (6%)
Query: 285 QDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKM 344
+D T + + ++ E A SV +A L E + ++ K ++ EKM
Sbjct: 2227 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK--MLKEKM 2284
Query: 345 QPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTE--- 401
Q + + +A Q + E+ +R +++ + Q+L G +R LE + +
Sbjct: 2285 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2344
Query: 402 ECSRLQELLERRKGEAQQSNKELQ-NMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEP 460
E S E L+ R E ++ + + +R Q E++ L + Q K+ VQ E
Sbjct: 2345 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2404
Query: 461 AKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHV-- 518
++ D RE + E+ K++++++ +L + + ++ +E++ Q ++
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2464
Query: 519 -----RQQYQRDTEQLRRSMQDATQDHAV----LEAERQKMSALVRGLQRELEETSEETG 569
Q +R EQ + ++ QD L E+Q+ + ++ L + EE
Sbjct: 2465 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2524
Query: 570 HWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKI-EVLQRELEQARASAGDTRQVE 628
Q ++ + Q+L Q R ++EE+ E +++ E LQ EQ RA+ + +V
Sbjct: 2525 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2584
Query: 629 VLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQK 688
+ +T ++ + + E H L ++++ R L+E + +
Sbjct: 2585 ASQVAATKTLPNGRD-ALDGPAAEAEPEHSFDGLRRKVSAQR--------LQEAGILSAE 2635
Query: 689 TLQQLRQ 695
LQ+L Q
Sbjct: 2636 ELQRLAQ 2642
Score = 48.1 bits (113), Expect = 5e-05
Identities = 126/582 (21%), Positives = 230/582 (39%), Gaps = 101/582 (17%)
Query: 455 VQGPEPAKEVLL---KDLLETRELLEEVLEGKQRVEEQLRLRE-RELTAL--------KG 502
V P+P ++ ++ L + + +V +G + E QLR +E REL L
Sbjct: 209 VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTA 268
Query: 503 ALKEE-VASRDQEVEHVRQQYQRDTEQ--------------LRRSMQDATQ--------D 539
A +E S +E+E + Q+ + E + +S++ A Q
Sbjct: 269 AFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG 328
Query: 540 HAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEM 599
+ L+ E++ V L+RE + SE E L ++ + +L+ME
Sbjct: 329 YHPLDVEKEWGKLHVAILEREKQLRSEF------------ERLECLQRIVTKLQMEAGLC 376
Query: 600 EEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRD 659
EE+L + +LQ ++ A R EV +++L + ++ L + Q+ + GRH
Sbjct: 377 EEQLNQADALLQSDVRLLAAGKVPQRAGEV-ERDLDKADSMIRLLFNDVQTLK-DGRHPQ 434
Query: 660 RELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRA 719
E + V R+ + L +T LR A+ A VA+ + +R
Sbjct: 435 GE-QMYRRVYRLH---------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPE 484
Query: 720 AVETTLRETQ------EEND------EFRRRILGLEQQLKETRGLVDGGEAVEARLR--- 764
++TLR Q EEN E+ + +E QL RGL E A++
Sbjct: 485 LEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR 544
Query: 765 -DKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRAL 823
D+ Q A + + L + L + +A LE +A +E LN
Sbjct: 545 SDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 604
Query: 824 EEE--------------GKQREVLRRGKAELEEQK-RLLDRTVDRLNKELEKIGEDSKQA 868
EEE K+ + EL+E+K + L DRL +E ++
Sbjct: 605 EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRE----DHPARPT 660
Query: 869 LQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAE 928
++ QA L+ + + K+ A+ + S + + ++Q+L++AL+ +
Sbjct: 661 VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQKLQEALRRKYS- 718
Query: 929 RDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEK 970
D+ RL+ L Q+A+++K ++ L GL ++
Sbjct: 719 -----CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 755
Score = 35.8 bits (81), Expect = 0.25
Identities = 117/542 (21%), Positives = 215/542 (39%), Gaps = 92/542 (16%)
Query: 626 QVEVLKKELLRTQE-ELKELQAER-------QSQEVAGR---------HRDRELEKQLAV 668
++E+L + L+ +E EL +A++ QS E A + + ++EK+
Sbjct: 281 EIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGK 340
Query: 669 LRV---EADRGRELEEQNLQ-LQKTLQQLRQD---CEEA-SKAKMVAEAEATVLG----- 715
L V E ++ E + L+ LQ+ + +L+ + CEE ++A + +++ +L
Sbjct: 341 LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVP 400
Query: 716 QRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQ 775
QR VE L ++ D R + Q LK+ R GE + R+ +RL A +
Sbjct: 401 QRAGEVERDL----DKADSMIRLLFNDVQTLKDGRH--PQGEQMYRRVYRLHERLVAIRT 454
Query: 776 QLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRR 835
+ L A G A A + + L+ QR R E TL L+
Sbjct: 455 EYNLRLKA-----GVAAPATQVAQVTLQSVQR---RPELEDSTLR-----------YLQD 495
Query: 836 GKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAK 895
A +EE + +D ++ + S + L Q +E+++ K R +D + Q
Sbjct: 496 LLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ---SIEEFRAKIERARSD-EGQLS 551
Query: 896 DWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGL-EQEAENKK 954
A + L RL + +L + +A ++ + L L E+E E
Sbjct: 552 PATRGAYRDC--LGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVG 609
Query: 955 RSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQ 1014
DR + +E S L EL+ ++ ++ L + +R L ++ AR
Sbjct: 610 FDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDR----------LLREDHPARP 659
Query: 1015 DLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQST 1074
+E + +L+ Q + E K +A+ Q S + +AE + + + ++
Sbjct: 660 TVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVR------EAEGQLQKLQEAL 713
Query: 1075 NRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQRE 1134
RK ++ED Q D+K+QL+ E L GL K+A+
Sbjct: 714 RRKYSCDRSATVTRLEDLLQDAQDEKEQLN--------------EYKGHLSGLAKRAKAV 759
Query: 1135 VE 1136
V+
Sbjct: 760 VQ 761
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 164 bits (415), Expect = 5e-40
Identities = 245/1062 (23%), Positives = 442/1062 (41%), Gaps = 115/1062 (10%)
Query: 207 EQRKRSKSLDSRLPRDTFEERERQSTNHWTSSTKYDNHVGTSK------QPAQSQNLSPL 260
E +RS + + R +F E+ Q + + HV ++ + AQ Q +
Sbjct: 1705 ETAQRSAEAELQSKRASFAEKTAQ-----LERSLQEEHVAVAQLREEAERRAQQQAEAER 1759
Query: 261 SGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQ-EAAPPGSVDHMKATIY 319
+ R+ + W L++ E R Q + Q KS ++Q E A + KA
Sbjct: 1760 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1819
Query: 320 GILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE-----LQRK 374
+ + +E E +R+++ + + +A QGE R++ E LQR+
Sbjct: 1820 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1879
Query: 375 LDEEVKKRQKLEPSQVGLERQLE------EKTEECSRL-----QELLERRKGEAQQSNKE 423
+KRQ+LE + ++E + EE SR ++ LE G ++ +E
Sbjct: 1880 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1939
Query: 424 LQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAK-----------EVLLKDLLET 472
++ L ++ + R E + + + V + A E+ LK+
Sbjct: 1940 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1999
Query: 473 RELLEEVLEG----KQRVEEQLRLR----ERELTALKGALKEEVASRDQEVEHV---RQQ 521
E L + E ++R+EEQ E L L+ A E+ + VE R+Q
Sbjct: 2000 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 2059
Query: 522 YQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKED 581
+ + L+ S + A A LE E ++ + R E+ E Q +E
Sbjct: 2060 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQLAAEEER 2118
Query: 582 LRATKQELLQLRMEKEE----MEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRT 637
R +E +Q + EE + E++E L+ ++E+AR Q + +L +
Sbjct: 2119 RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2178
Query: 638 QEELKELQAERQSQEVAGRHRDRELEKQLAV-------LRVEADRGR----ELEEQNLQL 686
+ K LQAE ++ A + +++EL++ L LR EA+ R E EE +Q
Sbjct: 2179 AAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2237
Query: 687 QKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDE-FRRRILGLEQQ 745
++ Q R+ EEA + K AE +A Q +AA E +E ++E + L Q+
Sbjct: 2238 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2297
Query: 746 LKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEA 805
+ + E LR K Q +E E L L + ++ L + L+A EA
Sbjct: 2298 QAADAEMEKHKKFAEQTLRQKAQ-VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2356
Query: 806 QRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLL-----DRTVDRLNKELEK 860
R +++ +E ++ +EE L + KA +E + R L D T L +E EK
Sbjct: 2357 ARQRSQVEEELFSVRVQMEE-------LSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2409
Query: 861 IGEDSKQALQQLQAQLED--YKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRL 918
+ + +++A + A E ++ A ++A + A+ E + +RL+ E + L
Sbjct: 2410 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2469
Query: 919 RQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQD-DRARQLKGLEEKVSRLETE 977
+Q + +Q + + DKE +AQ+L +E + +R+ + +R RQL+ + + RL+
Sbjct: 2470 QQQKELAQEQARRLQEDKEQMAQQLA---EETQGFQRTLEAERQRQLE-MSAEAERLKLR 2525
Query: 978 LDEEKNTVELLTDRVNRGRDQVDQL-----RTELMQERSAR--QDLECDKISLERQNKDL 1030
+ E + R R Q +++ RTEL + Q LE + + + L
Sbjct: 2526 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2585
Query: 1031 KTRLASSEGFQKP---SASLSQLES-------QNQLLQERLQAEER---EKTVLQSTNRK 1077
+ +A E ++ A L QL+S Q QLLQE ++ EK L R
Sbjct: 2586 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2645
Query: 1078 LERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEE 1137
+E++ +L +DE +++ +RQ + E+E +RL ++A+R E
Sbjct: 2646 IEQEKAKLEQLFQDEVAKAQQLREEQ-------QRQQQQMEQERQRLVASMEEARRRQHE 2698
Query: 1138 QHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEE 1179
E + Q ++ LE+ ++ A E+ E L EE
Sbjct: 2699 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2740
Score = 147 bits (370), Expect = 8e-35
Identities = 242/1007 (24%), Positives = 436/1007 (43%), Gaps = 137/1007 (13%)
Query: 270 QDWVLQSFE----EPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREG 325
+ W L +F E +R A L +++ LRD Q+A G D + A RE
Sbjct: 1044 RSWSLATFRTLKPEEQRQALHSLELHYQA---FLRDSQDAGGFGPEDRLMAE-----REY 1095
Query: 326 SSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGEL--------TRKVEELQRKLDE 377
S S +L+ ++ S + ++ ++ TR V L+ LD+
Sbjct: 1096 GSCSH-----HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1150
Query: 378 E--------VKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKR 429
E + ++QK + GL + + + E ++ L E A EL+
Sbjct: 1151 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA-APTLRSELELTLG 1209
Query: 430 LLDQGEDLRHGLETQVMELQNKLKHVQGPEP---AKEVLLKDLLETRELLEEVLEGKQRV 486
L+Q L ++ + ++ QG E A E LK+ L E LE +
Sbjct: 1210 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKAS 1268
Query: 487 EEQLRLRERELTALKGALKEEVASRDQEVEHVRQQY-QRDTEQLR---RSMQDATQDHAV 542
++LR + AL++E+ + E ++Q++ +RD E R R Q + AV
Sbjct: 1269 LKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV 1328
Query: 543 L---EAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKE--------DLRATKQELLQ 591
L + ++++ L R L R E+++ G W ++ +E D +A +++L Q
Sbjct: 1329 LAQTDVRQRELEQLGRQL-RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1387
Query: 592 LRMEKEEMEEELGEKIEVLQRELEQARASAGDTR-QVEVLKKELLRTQEELKELQAERQS 650
+ EE+E GEK+E QR +Q + D Q+ K +L K+ + + S
Sbjct: 1388 EQALLEEIERH-GEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1446
Query: 651 QEVAGRHRD-RELEKQLAVL-------------------RVEADRGRELEEQNLQLQKTL 690
+ V + D R +L L R+ + E E+ +++ L
Sbjct: 1447 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1506
Query: 691 QQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETR 750
++ RQ E ++AK AE EA L QR E + + +R I QQL+++
Sbjct: 1507 EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1566
Query: 751 GLVDGGEAVEARLRDKLQ-RLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGL 809
+A +A ++ + R+E E + + L A++ + G +AL AR EEA+
Sbjct: 1567 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1626
Query: 810 ARLGQEQQTLNRALEEEGKQR-----EVLRRGKAELE---EQKRLLDRTVDRLNKELEKI 861
+ +E + L R +++E +++ E+ R KAE E E++R L + ++ L + E+
Sbjct: 1627 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL-QALEELRLQAEEA 1685
Query: 862 GEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDE---IQRL 918
+QA + Q++ E A+R A+A+ Q+K AS AEKT+ LQ+E + +L
Sbjct: 1686 ERRLRQAEVERARQVQVALETAQRS-AEAELQSKR-ASFAEKTAQLERSLQEEHVAVAQL 1743
Query: 919 RQ-----ALQASQAERDTA-------------------RLDKELLAQRLQGLEQEAENKK 954
R+ A Q ++AER RL E +AQ+ + EAE +K
Sbjct: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803
Query: 955 RSQDDRARQLKGLEEKVSR----LETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQER 1010
+ AR+ EE+ R E EL++++ E + ++ +LR E Q
Sbjct: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863
Query: 1011 SARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQ-LLQERLQAEEREKT 1069
RQ LE + L+R+ A+++ Q+ A L+++ ++ + LL + +AEE ++
Sbjct: 1864 QQRQLLEEELARLQRE------AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1917
Query: 1070 VLQSTNRKLER---KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEI-ERLD 1125
+ + ++LE + +EL+ + R + K Q L + RQ EAE + E+L
Sbjct: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977
Query: 1126 G------LRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAE 1166
L+ +A+ ++E+ NE+L+ R+ E R+ AA+
Sbjct: 1978 AIGEATRLKTEAEIALKEKEAENERLR-RLAEDEAFQRRRLEEQAAQ 2023
Score = 143 bits (361), Expect = 9e-34
Identities = 201/875 (22%), Positives = 370/875 (42%), Gaps = 125/875 (14%)
Query: 278 EEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKV 337
EE RS + + + ++ R+ E A ++A R+ E + R++
Sbjct: 1912 EEESRSTSEKSKQRLEAEAGRFRELAEEAA-----RLRALAEEAKRQRQLAEEDAARQRA 1966
Query: 338 S---LVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLER 394
++ EK+ + + T+A E + E L+R ++E +R++LE +
Sbjct: 1967 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 2026
Query: 395 QLEEKTEECSRLQEL-LERRKG-------EAQQSNKELQNMK------------------ 428
+EE+ + + + LER+KG + +Q +E+ +K
Sbjct: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086
Query: 429 RLLDQGEDLRHGLETQVMELQNKLKHVQGPE----PAKEVLLKDLLETREL-------LE 477
R+ ED E +E + + E A+E + K L E LE
Sbjct: 2087 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2146
Query: 478 EVLEGKQRVEEQLRLRER------------------ELTALKGALKEEVASRDQEVEHVR 519
EV K +VEE RLRER L A + A V ++QE++
Sbjct: 2147 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2206
Query: 520 QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNK 579
QQ Q +QLR + A + A EAE ++ A +RE ++ + + + Q +
Sbjct: 2207 QQEQSVLDQLRGEAEAARR--AAEEAEEARVQA-----EREAAQSRRQVEEAERLKQSAE 2259
Query: 580 EDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQE 639
E +A Q ++E E+E + + Q L Q +A+ + + + ++ LR +
Sbjct: 2260 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2319
Query: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE 699
++++ + Q H+ L+++L L+ EA E Q Q+++ L +R EE
Sbjct: 2320 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT---EAARQRSQVEEELFSVRVQMEE 2376
Query: 700 ASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRR------RILGLEQQLKETRGLV 753
SK K EAE L R + T R QEE ++ ++ R+ Q+ R L
Sbjct: 2377 LSKLKARIEAENRALILRDK--DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2434
Query: 754 DGGEA-----VEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRG 808
+ A E L++K+Q ++ + EA Q++E + A+R E + + AQ+
Sbjct: 2435 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ- 2493
Query: 809 LARLGQEQQTLNRALEEEGKQR-------EVLRRGKAELEEQKRLLDRTVDRLNKELEKI 861
L +E Q R LE E +++ E L+ AE+ + + R K+ E+I
Sbjct: 2494 ---LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2550
Query: 862 GE---------DSKQALQQ---LQAQLEDYK-EKARREVADAQRQAKDWASEAEKTSGGL 908
GE K L Q +Q Q D+ E+ R +A+ +R+ + EA+ L
Sbjct: 2551 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL----L 2606
Query: 909 SRLQDEIQRLRQA--LQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKG 966
+E+Q ++Q LQ +QA + + +K+ L QR + +EQE ++ D + +
Sbjct: 2607 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2666
Query: 967 LEEKVSRLETELDEEKN----TVELLTDRVNRGRDQVDQLRTELMQ-ERSARQDLECDKI 1021
L E+ R + ++++E+ ++E R + + V + + EL Q E+ RQ E
Sbjct: 2667 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL--- 2723
Query: 1022 SLERQNKDLKTRLASSEGFQKPSASLSQLESQNQL 1056
L +N+ L+ +L E + + + S+ + +Q+
Sbjct: 2724 -LAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2757
Score = 133 bits (335), Expect = 9e-31
Identities = 177/778 (22%), Positives = 330/778 (42%), Gaps = 101/778 (12%)
Query: 315 KATIYGILREGSSESETSVRRKVSLVLEKM-------QPLVMVSSGSTKAVAGQGELTRK 367
KA I L + S++ + R+ LV + + + ++ + + KA AG+ EL +
Sbjct: 2025 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 2084
Query: 368 VEELQRKLDEEVKKRQKLEPSQVGLERQL-----EEKTEECSRLQELLERRKGEAQQSNK 422
+ ++ ++ ++ +++ E + +RQL + E R+Q+ L + A+Q
Sbjct: 2085 LGRIRSNAEDTLRSKEQAE-LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2143
Query: 423 ELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEG 482
L+ ++RL + E+ R E E +L+ Q E A++ L E + V +
Sbjct: 2144 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQ--EAAQKRLQA---EEKAHAFAVQQK 2198
Query: 483 KQRVEEQLRLRERELTALKGALKEEVASRD-QEVEHVRQQYQRDTEQLRRSMQDATQDHA 541
+Q +++ L+ + L L+G + E A R +E E R Q +R+ Q RR +++A +
Sbjct: 2199 EQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2256
Query: 542 VLEAERQ---KMSALVRGLQRELEETSEETGHWQ--SMFQKNKEDLRATK---------- 586
E + Q + A L++E E+ + + ++ QK D K
Sbjct: 2257 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2316
Query: 587 ------QELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEE 640
QEL LR++ EE + + E LQR +A +A QVE + EE
Sbjct: 2317 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376
Query: 641 LKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEA 700
L +L+A +++ A RD++ ++ L+ EA++ +++ E+ +L Q EA
Sbjct: 2377 LSKLKARIEAENRALILRDKDNTQRF--LQEEAEKMKQVAEEAARLSVAAQ-------EA 2427
Query: 701 SKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVE 760
++ + +AE + L Q+RA E L+E + E R E ++ + ++
Sbjct: 2428 ARLRQLAEED---LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2484
Query: 761 ARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLN 820
Q+L E Q + L A ++ + ++A L+ R+ E R AR ++ Q
Sbjct: 2485 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2544
Query: 821 RALEEEGKQ----------------------------REVLRRGKAELEEQKRLLDRTVD 852
+ EE G++ E LR AELE +K L +
Sbjct: 2545 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2604
Query: 853 RLNKELEKIGE-DSKQALQQLQAQLEDYKEKA----------RREVADAQRQAKDWASEA 901
L + E++ +Q LQ+ QA + + + +E A ++ +D ++A
Sbjct: 2605 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2664
Query: 902 EKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDD-- 959
++ R Q ++++ RQ L AS E + + E +R Q Q+ E ++R Q++
Sbjct: 2665 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2724
Query: 960 -----RAR-QLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERS 1011
R R QL+ LEE+ +E + T + GRD +D E E S
Sbjct: 2725 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS 2782
Score = 111 bits (277), Expect = 5e-24
Identities = 151/762 (19%), Positives = 328/762 (43%), Gaps = 93/762 (12%)
Query: 200 RTRMLPPEQRKRSKSLDSRLPRDTFEERER--------QSTNHWTSSTKYDNHVGTSKQP 251
R R L E+ +R + + R+ + E E + + + + +
Sbjct: 2108 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2167
Query: 252 AQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQ-DPTMLQFKSTPDLLRDQQEAAPPGS 310
++ L ++ R + +F ++ + T+ Q +S D LR + EAA +
Sbjct: 2168 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2227
Query: 311 VDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEE 370
E + E+ R+ + +++ + + + + + E+
Sbjct: 2228 -------------EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2274
Query: 371 LQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRL 430
L+++ ++E +R + E + + ++ + + E+ + E R+K + +Q EL ++
Sbjct: 2275 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ---ELTTLRLQ 2331
Query: 431 LDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQL 490
L++ + ++ L+ ++ L+ + E ++L R +EE+ + K R+E +
Sbjct: 2332 LEETDHQKNLLDEELQRLKAEATEAARQRSQVE---EELFSVRVQMEELSKLKARIEAEN 2388
Query: 491 R---LRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAER 547
R LR+++ T + L+EE Q E + +L + Q+A + + E +
Sbjct: 2389 RALILRDKDNT--QRFLQEEAEKMKQVAE--------EAARLSVAAQEAARLRQLAEEDL 2438
Query: 548 QKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKI 607
+ AL + +E + +E ++ + ++ +++ +L+ +KE+M ++L E+
Sbjct: 2439 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2498
Query: 608 EVLQRELEQARAS----AGDTRQVEVLKKELLRTQEELKE--LQAERQSQEVAGRHRDRE 661
+ QR LE R + + ++++ E+ R Q +E + +Q++E+ + E
Sbjct: 2499 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2558
Query: 662 LEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAV 721
L Q V V+ LE Q Q ++LR+ E + K + EA +L + +
Sbjct: 2559 LATQEKVTLVQT-----LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2613
Query: 722 ETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEAL 781
+T +E Q L+ET+ L + + L + + +E EK +LE+
Sbjct: 2614 QTVQQE----------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2657
Query: 782 NASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQR----EVLRRGK 837
++E + A R EE QR ++ QE+Q L ++EE +++ E +RR +
Sbjct: 2658 ----QDEVAKAQQLR------EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2707
Query: 838 AELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQ-----R 892
EL++ ++ + + L +E +++ E + +Q +A L +E +VA + R
Sbjct: 2708 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2767
Query: 893 QAKDW---ASEAEKTSGGLSRLQDEIQRLRQA--LQASQAER 929
A D +E E + GL R + QRL++A L A + +R
Sbjct: 2768 DALDGPAAEAEPEHSFDGLRR-KVSAQRLQEAGILSAEELQR 2808
Score = 103 bits (256), Expect = 1e-21
Identities = 185/831 (22%), Positives = 354/831 (42%), Gaps = 128/831 (15%)
Query: 397 EEKTEECSR-LQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHV 455
E + CS Q+LL+ + AQ+ ++ +R + + +D+R LE ++L+
Sbjct: 1092 EREYGSCSHHYQQLLQSLEQGAQEESR----CQRCISELKDIRLQLEACETRTVHRLRLP 1147
Query: 456 QGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEV 515
EPA+E + + E ++ EV EG + +L ++ AL E
Sbjct: 1148 LDKEPARECAQR-IAEQQKAQAEV-EGLGKGVARLSAEAEKVLALP------------EP 1193
Query: 516 EHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQ--RELEETSEETGHWQS 573
+ + E ++ A+ + + +S ++RG Q E+ EE
Sbjct: 1194 SPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1253
Query: 574 MFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKE 633
+L ATK L +LR + E + + L+ EL A+ E
Sbjct: 1254 AVPATLPELEATKASLKKLRAQAEAQQPTF----DALRDELRGAQEVG-----------E 1298
Query: 634 LLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQ---KTL 690
L+ + ++++ ER + VA + LE+ AVL R RELE+ QL+ ++
Sbjct: 1299 RLQQRHGERDVEVERWRERVA-----QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1353
Query: 691 QQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETR 750
L ++A + + +A Q AV LR+ Q +E R +E+ + +
Sbjct: 1354 DPLGAWLQDARRRQEQIQAMPLADSQ---AVREQLRQEQALLEEIERHGEKVEECQRFAK 1410
Query: 751 GLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQE---EEGSLAAAKRALEARLEEAQR 807
++ ++D +L K QLE + +++ + GS + + ++ R ++
Sbjct: 1411 QYINA-------IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE- 1462
Query: 808 GLARLGQE-----QQTLNRALEEE-------GKQREVLRRGKAELEEQKRLLDR------ 849
L L + +TL R EEE ++RE L +A LE+Q++L +
Sbjct: 1463 -LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1521
Query: 850 TVDRLNKEL-----------EKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWA 898
+R KEL E+ D++Q + +Q +L+ ++ + E+ QAK A
Sbjct: 1522 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI-----QAK--A 1574
Query: 899 SEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELL--------AQRLQGLEQEA 950
+AE R+++EI+ +R L+A++ +R A + + L AQ+ Q E+
Sbjct: 1575 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1634
Query: 951 ENKKRSQDDRARQLKGLEEKVSRLETELD---EEKNTVELLTDRVNRGRDQVDQLR-TEL 1006
+++ QD+ R+ + E SR++ E + E++ ++ L + + + +LR E+
Sbjct: 1635 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1694
Query: 1007 MQERSARQDLECDKISLERQNKDLKTRLAS-----SEGFQKPSASLSQLESQNQLLQERL 1061
+ R + LE + S E + + + A Q+ +++QL + + R
Sbjct: 1695 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE---AERRA 1751
Query: 1062 QAEEREKTVLQSTNRKLER---KVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAE 1118
Q + + + R+LER K E ++++ + + V QK SL ++Q +EAE
Sbjct: 1752 QQQAEAERAREEAERELERWQLKANE-ALRLRLQAEEVAQQK---SLAQAEAEKQKEEAE 1807
Query: 1119 EEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESAL 1169
E R R KA+ + Q E+ EQ + + L + + ++ R AAE L
Sbjct: 1808 REARR----RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ--RLAAEQEL 1852
Score = 86.3 bits (212), Expect = 2e-16
Identities = 160/694 (23%), Positives = 301/694 (43%), Gaps = 78/694 (11%)
Query: 520 QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQS---MFQ 576
Q +RD QL RS AT E +RQ + +L Q L ++ + G M +
Sbjct: 1034 QSLRRDV-QLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE 1092
Query: 577 KNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLR 636
+ Q+LLQ +E+ EE ++ +++ + + A +TR V L+ L
Sbjct: 1093 REYGSCSHHYQQLLQ-SLEQGAQEESRCQRCISELKDI-RLQLEACETRTVHRLRLPL-- 1148
Query: 637 TQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQD 696
+E +E A+R +++ + L K +A L EA++ L E + LR +
Sbjct: 1149 DKEPAREC-AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSE 1203
Query: 697 CE-EASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGL--- 752
E K + V A L ++ + +R TQ + R E+QLKE + +
Sbjct: 1204 LELTLGKLEQVRSLSAIYL-EKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPAT 1258
Query: 753 VDGGEAVEARLRDKLQRLEAEKQQ-----LEEALNASQEEEGSLAAAKRALEARLEEAQR 807
+ EA +A L K R +AE QQ L + L +QE L + +E +
Sbjct: 1259 LPELEATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1316
Query: 808 GLARLGQEQQTL-------NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEK 860
+A+L + Q + R LE+ G+Q R L + R +++
Sbjct: 1317 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1376
Query: 861 IGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQ 920
+ ++ L+Q QA LE+ E+ +V + QR AK + + + L + +++ +
Sbjct: 1377 DSQAVREQLRQEQALLEEI-ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-- 1433
Query: 921 ALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETE--L 978
AS A++ + E + Q L ++ +K + E + R+E E L
Sbjct: 1434 ---ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT---SQYIKFISETLRRMEEEERL 1487
Query: 979 DEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE 1038
E++ E R+++ ++ L ++R + K ER+ K+L+ R+ E
Sbjct: 1488 AEQQRAEE---------RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM-QEE 1537
Query: 1039 GFQKPSASLSQLESQNQLLQERL-----------QAEEREKTVLQSTNRKLERKVKELSI 1087
++ A++ + Q + +QE L QA+ R+ + + ++E +++ + +
Sbjct: 1538 VVRREEAAVDA-QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1596
Query: 1088 QIE-DERQHVNDQKDQLSLRVKA--LKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQ 1144
Q+E ERQ + + +LR +A + Q +A+EE ER LR++ Q E + + + +
Sbjct: 1597 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER---LRRQVQDESQRKRQAEVE 1653
Query: 1145 LQARIKSLEKDSWRKASRSAAESALKNEGLSSDE 1178
L +R+K+ E ++ R+ R A AL+ L ++E
Sbjct: 1654 LASRVKA-EAEAAREKQR--ALQALEELRLQAEE 1684
Score = 62.4 bits (150), Expect = 3e-09
Identities = 86/427 (20%), Positives = 178/427 (41%), Gaps = 27/427 (6%)
Query: 285 QDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKM 344
+D T + + ++ E A SV +A L E + ++ K ++ EKM
Sbjct: 2396 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK--MLKEKM 2453
Query: 345 QPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTE--- 401
Q + + +A Q + E+ +R +++ + Q+L G +R LE + +
Sbjct: 2454 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2513
Query: 402 ECSRLQELLERRKGEAQQSNKELQ-NMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEP 460
E S E L+ R E ++ + + +R Q E++ L + Q K+ VQ E
Sbjct: 2514 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2573
Query: 461 AKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHV-- 518
++ D RE + E+ K++++++ +L + + ++ +E++ Q ++
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2633
Query: 519 -----RQQYQRDTEQLRRSMQDATQDHAV----LEAERQKMSALVRGLQRELEETSEETG 569
Q +R EQ + ++ QD L E+Q+ + ++ L + EE
Sbjct: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2693
Query: 570 HWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKI-EVLQRELEQARASAGDTRQVE 628
Q ++ + Q+L Q R ++EE+ E +++ E LQ EQ RA+ + +V
Sbjct: 2694 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2753
Query: 629 VLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQK 688
+ +T ++ + + E H L ++++ R L+E + +
Sbjct: 2754 ASQVAATKTLPNGRD-ALDGPAAEAEPEHSFDGLRRKVSAQR--------LQEAGILSAE 2804
Query: 689 TLQQLRQ 695
LQ+L Q
Sbjct: 2805 ELQRLAQ 2811
Score = 48.1 bits (113), Expect = 5e-05
Identities = 126/582 (21%), Positives = 230/582 (39%), Gaps = 101/582 (17%)
Query: 455 VQGPEPAKEVLL---KDLLETRELLEEVLEGKQRVEEQLRLRE-RELTAL--------KG 502
V P+P ++ ++ L + + +V +G + E QLR +E REL L
Sbjct: 378 VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTA 437
Query: 503 ALKEE-VASRDQEVEHVRQQYQRDTEQ--------------LRRSMQDATQ--------D 539
A +E S +E+E + Q+ + E + +S++ A Q
Sbjct: 438 AFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG 497
Query: 540 HAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEM 599
+ L+ E++ V L+RE + SE E L ++ + +L+ME
Sbjct: 498 YHPLDVEKEWGKLHVAILEREKQLRSEF------------ERLECLQRIVTKLQMEAGLC 545
Query: 600 EEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRD 659
EE+L + +LQ ++ A R EV +++L + ++ L + Q+ + GRH
Sbjct: 546 EEQLNQADALLQSDVRLLAAGKVPQRAGEV-ERDLDKADSMIRLLFNDVQTLK-DGRHPQ 603
Query: 660 RELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRA 719
E + V R+ + L +T LR A+ A VA+ + +R
Sbjct: 604 GE-QMYRRVYRLH---------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPE 653
Query: 720 AVETTLRETQ------EEND------EFRRRILGLEQQLKETRGLVDGGEAVEARLR--- 764
++TLR Q EEN E+ + +E QL RGL E A++
Sbjct: 654 LEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR 713
Query: 765 -DKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRAL 823
D+ Q A + + L + L + +A LE +A +E LN
Sbjct: 714 SDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 773
Query: 824 EEE--------------GKQREVLRRGKAELEEQK-RLLDRTVDRLNKELEKIGEDSKQA 868
EEE K+ + EL+E+K + L DRL +E ++
Sbjct: 774 EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRE----DHPARPT 829
Query: 869 LQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAE 928
++ QA L+ + + K+ A+ + S + + ++Q+L++AL+ +
Sbjct: 830 VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQKLQEALRRKYS- 887
Query: 929 RDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEK 970
D+ RL+ L Q+A+++K ++ L GL ++
Sbjct: 888 -----CDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 924
Score = 35.8 bits (81), Expect = 0.25
Identities = 117/542 (21%), Positives = 215/542 (39%), Gaps = 92/542 (16%)
Query: 626 QVEVLKKELLRTQE-ELKELQAER-------QSQEVAGR---------HRDRELEKQLAV 668
++E+L + L+ +E EL +A++ QS E A + + ++EK+
Sbjct: 450 EIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGK 509
Query: 669 LRV---EADRGRELEEQNLQ-LQKTLQQLRQD---CEEA-SKAKMVAEAEATVLG----- 715
L V E ++ E + L+ LQ+ + +L+ + CEE ++A + +++ +L
Sbjct: 510 LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVP 569
Query: 716 QRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQ 775
QR VE L ++ D R + Q LK+ R GE + R+ +RL A +
Sbjct: 570 QRAGEVERDL----DKADSMIRLLFNDVQTLKDGRH--PQGEQMYRRVYRLHERLVAIRT 623
Query: 776 QLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRR 835
+ L A G A A + + L+ QR R E TL L+
Sbjct: 624 EYNLRLKA-----GVAAPATQVAQVTLQSVQR---RPELEDSTLR-----------YLQD 664
Query: 836 GKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAK 895
A +EE + +D ++ + S + L Q +E+++ K R +D + Q
Sbjct: 665 LLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQ---SIEEFRAKIERARSD-EGQLS 720
Query: 896 DWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGL-EQEAENKK 954
A + L RL + +L + +A ++ + L L E+E E
Sbjct: 721 PATRGAYRDC--LGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVG 778
Query: 955 RSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQ 1014
DR + +E S L EL+ ++ ++ L + +R L ++ AR
Sbjct: 779 FDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDR----------LLREDHPARP 828
Query: 1015 DLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQST 1074
+E + +L+ Q + E K +A+ Q S + +AE + + + ++
Sbjct: 829 TVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVR------EAEGQLQKLQEAL 882
Query: 1075 NRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQRE 1134
RK ++ED Q D+K+QL+ E L GL K+A+
Sbjct: 883 RRKYSCDRSATVTRLEDLLQDAQDEKEQLN--------------EYKGHLSGLAKRAKAV 928
Query: 1135 VE 1136
V+
Sbjct: 929 VQ 930
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.125 0.324
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,843,972
Number of Sequences: 37866
Number of extensions: 2058564
Number of successful extensions: 50575
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 762
Number of HSP's successfully gapped in prelim test: 1501
Number of HSP's that attempted gapping in prelim test: 11895
Number of HSP's gapped (non-prelim): 13420
length of query: 1203
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1089
effective length of database: 13,930,794
effective search space: 15170634666
effective search space used: 15170634666
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.