Guide to the Human Genome
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Search of human proteins with 160707881

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|160707881 formin 2 [Homo sapiens]
         (1722 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|160707881 formin 2 [Homo sapiens]                                 3553   0.0  
gi|157168329 formin 1 [Homo sapiens]                                  556   e-158
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]                    317   8e-86
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]                    317   8e-86
gi|163965366 nascent polypeptide-associated complex alpha subuni...   196   2e-49
gi|47132519 Ras association and pleckstrin homology domains 1 is...   191   7e-48
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]               191   7e-48
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]               191   7e-48
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   182   2e-45
gi|33356148 formin-like 1 [Homo sapiens]                              182   2e-45
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]                    180   1e-44
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]                    180   1e-44
gi|21071077 dishevelled-associated activator of morphogenesis 1 ...   177   8e-44
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]             177   1e-43
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]            177   1e-43
gi|15890086 type IV collagen alpha 5 isoform 2 precursor [Homo s...   168   5e-41
gi|15890088 type IV collagen alpha 5 isoform 3 precursor [Homo s...   168   5e-41
gi|40548415 dishevelled associated activator of morphogenesis 2 ...   167   8e-41
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]    167   1e-40
gi|4502955 type IV collagen alpha 5 isoform 1 precursor [Homo sa...   166   1e-40
gi|32895368 alpha 1 type VIII collagen precursor [Homo sapiens]       164   7e-40
gi|17738302 alpha 1 type VIII collagen precursor [Homo sapiens]       164   7e-40
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]      162   3e-39
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo...   156   2e-37
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ...   156   2e-37
gi|52485606 formin-like 2 [Homo sapiens]                              155   3e-37
gi|148536848 carboxyl ester lipase precursor [Homo sapiens]           155   4e-37
gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens]              155   4e-37
gi|116284392 mucin 2 precursor [Homo sapiens]                         154   9e-37
gi|150417989 cyclin K isoform 1 [Homo sapiens]                        148   5e-35

>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score = 3553 bits (9212), Expect = 0.0
 Identities = 1722/1722 (100%), Positives = 1722/1722 (100%)

Query: 1    MGNQDGKLKRSAGDALHEGGGGAEDALGPRDVEATKKGSGGKKALGKHGKGGGGGGGGGE 60
            MGNQDGKLKRSAGDALHEGGGGAEDALGPRDVEATKKGSGGKKALGKHGKGGGGGGGGGE
Sbjct: 1    MGNQDGKLKRSAGDALHEGGGGAEDALGPRDVEATKKGSGGKKALGKHGKGGGGGGGGGE 60

Query: 61   SGKKKSKSDSRASVFSNLRIRKNLSKGKGAGGSREDVLDSQALQTGELDSAHSLLTKTPD 120
            SGKKKSKSDSRASVFSNLRIRKNLSKGKGAGGSREDVLDSQALQTGELDSAHSLLTKTPD
Sbjct: 61   SGKKKSKSDSRASVFSNLRIRKNLSKGKGAGGSREDVLDSQALQTGELDSAHSLLTKTPD 120

Query: 121  LSLSADEAGLSDTECADPFEVTGPGGPGPAEARVGGRPIAEDVETAAGAQDGQRTSSGSD 180
            LSLSADEAGLSDTECADPFEVTGPGGPGPAEARVGGRPIAEDVETAAGAQDGQRTSSGSD
Sbjct: 121  LSLSADEAGLSDTECADPFEVTGPGGPGPAEARVGGRPIAEDVETAAGAQDGQRTSSGSD 180

Query: 181  TDIYSFHSATEQEDLLSDIQQAIRLQQQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVS 240
            TDIYSFHSATEQEDLLSDIQQAIRLQQQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVS
Sbjct: 181  TDIYSFHSATEQEDLLSDIQQAIRLQQQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVS 240

Query: 241  PQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLP 300
            PQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLP
Sbjct: 241  PQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLP 300

Query: 301  VSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRG 360
            VSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRG
Sbjct: 301  VSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRG 360

Query: 361  SPGEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCYIK 420
            SPGEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCYIK
Sbjct: 361  SPGEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCYIK 420

Query: 421  TTTRQLSSPNHSPSQSPNQSPRIKRRPEPSLSRGSRTALASVAAPAKKHRADGGLAAGLS 480
            TTTRQLSSPNHSPSQSPNQSPRIKRRPEPSLSRGSRTALASVAAPAKKHRADGGLAAGLS
Sbjct: 421  TTTRQLSSPNHSPSQSPNQSPRIKRRPEPSLSRGSRTALASVAAPAKKHRADGGLAAGLS 480

Query: 481  RSADWTEELGARTPRVGGSAHLLERGVASDSGGGVSPALAAKASGAPAAADGFQNVFTGR 540
            RSADWTEELGARTPRVGGSAHLLERGVASDSGGGVSPALAAKASGAPAAADGFQNVFTGR
Sbjct: 481  RSADWTEELGARTPRVGGSAHLLERGVASDSGGGVSPALAAKASGAPAAADGFQNVFTGR 540

Query: 541  TLLEKLFSQQENGPPEEAEKFCSRIIAMGLLLPFSDCFREPCNQNAQTNAASFDQDQLYT 600
            TLLEKLFSQQENGPPEEAEKFCSRIIAMGLLLPFSDCFREPCNQNAQTNAASFDQDQLYT
Sbjct: 541  TLLEKLFSQQENGPPEEAEKFCSRIIAMGLLLPFSDCFREPCNQNAQTNAASFDQDQLYT 600

Query: 601  WAAVSQPTHSLDYSEGQFPRRVPSMGPPSKPPDEEHRLEDAETESQSAVSETPQKRSDAV 660
            WAAVSQPTHSLDYSEGQFPRRVPSMGPPSKPPDEEHRLEDAETESQSAVSETPQKRSDAV
Sbjct: 601  WAAVSQPTHSLDYSEGQFPRRVPSMGPPSKPPDEEHRLEDAETESQSAVSETPQKRSDAV 660

Query: 661  QKEVVDMKSEGQATVIQQLEQTIEDLRTKIAELERQYPALDTEVASGHQGLENGVTASGD 720
            QKEVVDMKSEGQATVIQQLEQTIEDLRTKIAELERQYPALDTEVASGHQGLENGVTASGD
Sbjct: 661  QKEVVDMKSEGQATVIQQLEQTIEDLRTKIAELERQYPALDTEVASGHQGLENGVTASGD 720

Query: 721  VCLEALRLEEKEVRHHRILEAKSIQTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTK 780
            VCLEALRLEEKEVRHHRILEAKSIQTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTK
Sbjct: 721  VCLEALRLEEKEVRHHRILEAKSIQTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTK 780

Query: 781  FCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTS 840
            FCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTS
Sbjct: 781  FCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTS 840

Query: 841  HEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPP 900
            HEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPP
Sbjct: 841  HEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPP 900

Query: 901  PLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLP 960
            PLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLP
Sbjct: 901  PLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLP 960

Query: 961  GAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1020
            GAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP
Sbjct: 961  GAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1020

Query: 1021 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1080
            PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL
Sbjct: 1021 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1080

Query: 1081 PGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1140
            PGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI
Sbjct: 1081 PGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1140

Query: 1141 PPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPP 1200
            PPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPP
Sbjct: 1141 PPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPP 1200

Query: 1201 LPGAGIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVC 1260
            LPGAGIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVC
Sbjct: 1201 LPGAGIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVC 1260

Query: 1261 GFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRIQLHSKRDSSTSLIWEKIEE 1320
            GFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRIQLHSKRDSSTSLIWEKIEE
Sbjct: 1261 GFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRIQLHSKRDSSTSLIWEKIEE 1320

Query: 1321 PSIDCHEFEELFSKTAVKERKKPISDTISKTKAKQVVKLLSNKRSQAVGILMSSLHLDMK 1380
            PSIDCHEFEELFSKTAVKERKKPISDTISKTKAKQVVKLLSNKRSQAVGILMSSLHLDMK
Sbjct: 1321 PSIDCHEFEELFSKTAVKERKKPISDTISKTKAKQVVKLLSNKRSQAVGILMSSLHLDMK 1380

Query: 1381 DIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYE 1440
            DIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYE
Sbjct: 1381 DIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYE 1440

Query: 1441 LSLIPNFSERVFCILFQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNY 1500
            LSLIPNFSERVFCILFQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNY
Sbjct: 1441 LSLIPNFSERVFCILFQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNY 1500

Query: 1501 MNGGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLP 1560
            MNGGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLP
Sbjct: 1501 MNGGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLP 1560

Query: 1561 EPQDLFQASQMKFEDFQKDLRKLKKDLKACEVEAGKVYQVSSKEHMQPFKENMEQFIIQA 1620
            EPQDLFQASQMKFEDFQKDLRKLKKDLKACEVEAGKVYQVSSKEHMQPFKENMEQFIIQA
Sbjct: 1561 EPQDLFQASQMKFEDFQKDLRKLKKDLKACEVEAGKVYQVSSKEHMQPFKENMEQFIIQA 1620

Query: 1621 KIDQEAEENSLTETHKCFLETTAYFFMKPKLGEKEVSPNAFFSIWHEFSSDFKDFWKKEN 1680
            KIDQEAEENSLTETHKCFLETTAYFFMKPKLGEKEVSPNAFFSIWHEFSSDFKDFWKKEN
Sbjct: 1621 KIDQEAEENSLTETHKCFLETTAYFFMKPKLGEKEVSPNAFFSIWHEFSSDFKDFWKKEN 1680

Query: 1681 KLLLQERVKEAEEVCRQKKGKSLYKIKPRHDSGIKAKISMKT 1722
            KLLLQERVKEAEEVCRQKKGKSLYKIKPRHDSGIKAKISMKT
Sbjct: 1681 KLLLQERVKEAEEVCRQKKGKSLYKIKPRHDSGIKAKISMKT 1722


>gi|157168329 formin 1 [Homo sapiens]
          Length = 1196

 Score =  556 bits (1432), Expect = e-158
 Identities = 294/576 (51%), Positives = 380/576 (65%), Gaps = 36/576 (6%)

Query: 1151 IPPPPPLPGAGIPPPPPLPGA--GIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPP 1208
            +PPPP    A IPPPPPLP     + P PP+P V   PP P      PPPPP      PP
Sbjct: 645  LPPPP----ASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLP------PPPPP------PP 688

Query: 1209 PPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLP 1268
            P P P    PP P PP P P +  PP P     GPP          P P   G  PPP P
Sbjct: 689  PLPPPSSAGPPPPPPPPPLPNSPAPPNP----GGPP----------PAPPPPGLAPPPPP 734

Query: 1269 SGLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRIQLHSKRDSSTSLIWEKIEEPSI-DCHE 1327
               FGLG +  +  RK  IEP  PMKPLYWTRIQ+  +  ++T  +W+ +EEP I D  E
Sbjct: 735  GLFFGLGSSSSQCPRKPAIEPSCPMKPLYWTRIQISDRSQNATPTLWDSLEEPDIRDPSE 794

Query: 1328 FEELFSKTAVKERKKPISDTISK-TKAKQVVKLLSNKRSQAVGILMSSLHLDMKDIQHAV 1386
            FE LFSK   +++KKP+S+T  K  K K+++KLL  KRSQ VGIL+SSLHL+MKDIQ A+
Sbjct: 795  FEYLFSKDTTQQKKKPLSETYEKKNKVKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAI 854

Query: 1387 VNLDNSVVDLETLQALYENRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYELSLIPN 1446
             N+D+SVVDLETL ALYENRAQ DEL KI K+  +SK++E  K LDKPEQFL+EL+ IPN
Sbjct: 855  FNVDDSVVDLETLAALYENRAQEDELVKIRKYYETSKEEE-LKLLDKPEQFLHELAQIPN 913

Query: 1447 FSERVFCILFQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNYMNGGNK 1506
            F+ER  CI+F+S FSE I S+ RK+E++ +  + L +   V  +L L+LAFGNYMNGGN+
Sbjct: 914  FAERAQCIIFRSVFSEGITSLHRKVEIITRASKDLLHVKSVKDILALILAFGNYMNGGNR 973

Query: 1507 TRGQADGFGLDILPKLKDVKSSDNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLPEPQDLF 1566
            TRGQADG+ L+ILPKLKDVKS DN  +L+ Y+V YYLR +D++AG E+ +FPLPEPQD F
Sbjct: 974  TRGQADGYSLEILPKLKDVKSRDNGINLVDYVVKYYLRYYDQEAGTEKSVFPLPEPQDFF 1033

Query: 1567 QASQMKFEDFQKDLRKLKKDLKACEVEAGKVYQVSSKEHMQPFKENMEQFIIQAKIDQEA 1626
             ASQ+KFED  KDLRKLK+ L+A E +   V + S KE++QPFK+ +E+F  +AK + + 
Sbjct: 1034 LASQVKFEDLIKDLRKLKRQLEASEKQMVVVCKESPKEYLQPFKDKLEEFFQKAKKEHKM 1093

Query: 1627 EENSLTETHKCFLETTAYFFMKPKLGEKEVSPNAFFSIWHEFSSDFKDFWKKENKLLLQE 1686
            EE+ L    K F  T  YF MKPK GEKE++P+  F +W+EF SDFK  WK+E+K + +E
Sbjct: 1094 EESHLENAQKSFETTVRYFGMKPKSGEKEITPSYVFMVWYEFCSDFKTIWKRESKNISKE 1153

Query: 1687 RVKEAEE-VCRQKKGKSLYKIKPRHDSGIKAKISMK 1721
            R+K A+E V +    K +   K    + +K ++  K
Sbjct: 1154 RLKMAQESVSKLTSEKKVETKKINPTASLKERLRQK 1189



 Score =  103 bits (256), Expect = 2e-21
 Identities = 59/119 (49%), Positives = 65/119 (54%), Gaps = 29/119 (24%)

Query: 1074 IPPPPPLPGAGIPPPPPLPGA--GIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPP 1131
            +PPPP    A IPPPPPLP     + P PP+P V   PP       +PPPPP P    PP
Sbjct: 645  LPPPP----ASIPPPPPLPSGLGSLSPAPPMPPVSAGPP-------LPPPPPPP----PP 689

Query: 1132 PPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPL 1190
             PP   AG PPP        PPPPPLP +   P PP PG G PP PP PG+  PPPP L
Sbjct: 690  LPPPSSAGPPPP--------PPPPPLPNS---PAPPNPG-GPPPAPPPPGLAPPPPPGL 736



 Score =  102 bits (253), Expect = 4e-21
 Identities = 58/119 (48%), Positives = 63/119 (52%), Gaps = 29/119 (24%)

Query: 1008 IPPPPPLPGAGIPPPPPLPG--AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1065
            +PPPP    A IPPPPPLP     + P PP+P     PP P      PPPPP      PP
Sbjct: 645  LPPPP----ASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLP------PPPPP------PP 688

Query: 1066 PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPL 1124
            P P P +  PPPP       PPPPPLP +   P PP PG G PP PP PG   PPPP L
Sbjct: 689  PLPPPSSAGPPPP-------PPPPPLPNS---PAPPNPG-GPPPAPPPPGLAPPPPPGL 736



 Score =  101 bits (252), Expect = 5e-21
 Identities = 66/160 (41%), Positives = 78/160 (48%), Gaps = 20/160 (12%)

Query: 882  PLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLP-GAGIPPPPPLPGAGILPLPPLPGA 940
            P    +  T  +  +P+   +     L PP       A + P   +       LPP P A
Sbjct: 592  PCESESKTTRSNQLVPKKLNISSLSQLSPPNDHKDIHAALQPMEGMASNQQKALPP-PPA 650

Query: 941  GIPPPPPLPG--AAIPPPPPLP--GAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 996
             IPPPPPLP    ++ P PP+P   AG PLPPP P    PPPP  P +   PPPP     
Sbjct: 651  SIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPP----PPPPLPPPSSAGPPPP----- 701

Query: 997  IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1036
             PPPPPLP +   P PP PG G PP PP PG   PPPP L
Sbjct: 702  -PPPPPLPNS---PAPPNPG-GPPPAPPPPGLAPPPPPGL 736



 Score =  100 bits (250), Expect = 9e-21
 Identities = 58/119 (48%), Positives = 63/119 (52%), Gaps = 29/119 (24%)

Query: 975  IPPPPPLPGAGIPPPPPLPGA--GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1032
            +PPPP    A IPPPPPLP     + P PP+P     PP       +PPPPP P    PP
Sbjct: 645  LPPPP----ASIPPPPPLPSGLGSLSPAPPMPPVSAGPP-------LPPPPPPP----PP 689

Query: 1033 PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1091
             PP   AG PPP        PPPPPLP +   P PP PG G PP PP PG   PPPP L
Sbjct: 690  LPPPSSAGPPPP--------PPPPPLPNS---PAPPNPG-GPPPAPPPPGLAPPPPPGL 736



 Score =  100 bits (250), Expect = 9e-21
 Identities = 58/119 (48%), Positives = 63/119 (52%), Gaps = 29/119 (24%)

Query: 986  IPPPPPLPGAGIPPPPPLPGA--GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1043
            +PPPP    A IPPPPPLP     + P PP+P     PP       +PPPPP P    PP
Sbjct: 645  LPPPP----ASIPPPPPLPSGLGSLSPAPPMPPVSAGPP-------LPPPPPPP----PP 689

Query: 1044 PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1102
             PP   AG PPP        PPPPPLP +   P PP PG G PP PP PG   PPPP L
Sbjct: 690  LPPPSSAGPPPP--------PPPPPLPNS---PAPPNPG-GPPPAPPPPGLAPPPPPGL 736



 Score =  100 bits (250), Expect = 9e-21
 Identities = 58/119 (48%), Positives = 63/119 (52%), Gaps = 29/119 (24%)

Query: 1030 IPPPPPLPGAGIPPPPPLPGA--GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1087
            +PPPP    A IPPPPPLP     + P PP+P     PP       +PPPPP P    PP
Sbjct: 645  LPPPP----ASIPPPPPLPSGLGSLSPAPPMPPVSAGPP-------LPPPPPPP----PP 689

Query: 1088 PPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1146
             PP   AG PPP        PPPPPLP +   P PP PG G PP PP PG   PPPP L
Sbjct: 690  LPPPSSAGPPPP--------PPPPPLPNS---PAPPNPG-GPPPAPPPPGLAPPPPPGL 736



 Score =  100 bits (248), Expect = 2e-20
 Identities = 60/118 (50%), Positives = 64/118 (54%), Gaps = 27/118 (22%)

Query: 942  IPPPPPLPGAAIPPPPPLP-GAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1000
            +PPPP    A+IPPPPPLP G G   P P      P PP   G  +PPPPP P    PP 
Sbjct: 645  LPPPP----ASIPPPPPLPSGLGSLSPAP------PMPPVSAGPPLPPPPPPP----PPL 690

Query: 1001 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1058
            PP   AG PPP        PPPPPLP +   P PP PG G PP PP PG   PPPP L
Sbjct: 691  PPPSSAGPPPP--------PPPPPLPNS---PAPPNPG-GPPPAPPPPGLAPPPPPGL 736



 Score =  100 bits (248), Expect = 2e-20
 Identities = 58/117 (49%), Positives = 62/117 (52%), Gaps = 27/117 (23%)

Query: 966  LPPPLPGAGIPPPPPLPG--AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1023
            LPPP   A IPPPPPLP     + P PP+P     PP P      PPPPP      PPP 
Sbjct: 645  LPPP--PASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLP------PPPPP------PPPL 690

Query: 1024 PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1080
            P P +  PPPP       PPPPPLP +   P PP PG G PP PP PG   PPPP L
Sbjct: 691  PPPSSAGPPPP-------PPPPPLPNS---PAPPNPG-GPPPAPPPPGLAPPPPPGL 736



 Score = 99.0 bits (245), Expect = 4e-20
 Identities = 56/119 (47%), Positives = 61/119 (51%), Gaps = 29/119 (24%)

Query: 1052 IPPPPPLPGAGIPPPPPLPGA--GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPP 1109
            +PPPP    A IPPPPPLP     + P PP+P     PP       +PPPPP P    PP
Sbjct: 645  LPPPP----ASIPPPPPLPSGLGSLSPAPPMPPVSAGPP-------LPPPPPPP----PP 689

Query: 1110 PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPL 1168
             PP   AG PPP        PPPPPLP +  PP P     G PP PP PG   PPPP L
Sbjct: 690  LPPPSSAGPPPP--------PPPPPLPNSPAPPNPG----GPPPAPPPPGLAPPPPPGL 736



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 94/339 (27%), Positives = 134/339 (39%), Gaps = 53/339 (15%)

Query: 623 PSMGPP-SKPPDEEHRLEDAETESQSAVSETPQKRSDAVQKEVVDM-KSEGQATVIQQLE 680
           P+ GP  SK PD     +D  T  +      P K  D  +K  +   ++E QA ++    
Sbjct: 449 PADGPSDSKSPDHSLTEQDDRTPGRLQAVWPPPKTKDTEEKVGLKYTEAEYQAAILHLKR 508

Query: 681 QTIEDLRTKIAELERQYPALDTEVASGHQGLENGVTASGDVCLEALRLEEKEVRHHRILE 740
           +  E++    A+ E +        A   +G    +TA  +  +E L+ E +        E
Sbjct: 509 EHKEEIENLQAQFELR--------AFHIRGEHAMITARLEETIENLKHELEHRWRGGCEE 560

Query: 741 AKSIQTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDS 800
            K +  S  ++    T   V     R       ES  +T   +++     P+++++    
Sbjct: 561 RKDVCISTDDDCPPKTFRNVCVQTDRETFLKPCESESKTTRSNQLV----PKKLNIS--- 613

Query: 801 HQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPP 860
                S+SQ  PP              +  H+     +    +   +      +IP PPP
Sbjct: 614 -----SLSQLSPPND-----------HKDIHAALQPMEGMASNQQKALPPPPASIPPPPP 657

Query: 861 LPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGI 920
           LP         GLG + P PP  P    P LP    P PPP       PPP PP   AG 
Sbjct: 658 LPS--------GLGSLSPAPPMPPVSAGPPLP----PPPPP-------PPPLPPPSSAGP 698

Query: 921 PPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPL 959
           PPPPP P     P PP PG G PP PP PG A PPPP L
Sbjct: 699 PPPPPPPPLPNSPAPPNPG-GPPPAPPPPGLAPPPPPGL 736


>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
          Length = 1263

 Score =  317 bits (811), Expect = 8e-86
 Identities = 245/703 (34%), Positives = 339/703 (48%), Gaps = 129/703 (18%)

Query: 1025 LPGAGIPPPPPLPG-AGIPPPPPLPGAG--IPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1081
            L  A I  PP +P  A +PP PPLPG    I PPPP PG    PPPP       PPPP  
Sbjct: 556  LSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPP-------PPPP-- 606

Query: 1082 GAGIPPPPPLPGAG-IPPPPPLPG-VGIPPPPPLPG-AGIPPPPPLP-GAGIPPPPPLP- 1136
                PPPPPLPG   I  PP LPG   I PPPPL G A IPPPPPLP G GIP P  LP 
Sbjct: 607  ----PPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPG 662

Query: 1137 GAGIPPPPPLPRVG--IPPPPPLPG-AGI-PPPPPLPG-AGIPPPPPLPGVGIPPPPPLP 1191
            G  IPPPPPLP      PPPPPLPG AGI PPPPPLPG AG+P          PPPPPLP
Sbjct: 663  GTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMP----------PPPPPLP 712

Query: 1192 -GVGIPPPPPLPGA-GIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQV 1249
             G GIPPPPP PG  GIPPPP  PGMG+PP      PP G G+P  P+LP          
Sbjct: 713  GGPGIPPPPPFPGGPGIPPPP--PGMGMPPP-----PPFGFGVPAAPVLP---------- 755

Query: 1250 GSSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRIQLHSKRDS 1309
                                  FGL       + K+  +P   ++   W+++      D 
Sbjct: 756  ----------------------FGL-------TPKKLYKPEVQLRRPNWSKL---VAEDL 783

Query: 1310 STSLIWEKIEEPSIDCHEFEELFSK--------TAVKERKK-----PISDTISKTKAKQV 1356
            S    W K++E   D  E  ELF+K        T   + KK         ++ K K K+ 
Sbjct: 784  SQDCFWTKVKE---DRFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKE- 839

Query: 1357 VKLLSNKRSQAVGILMSSLHLDMKDIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIE 1416
            +K+L +K +Q + I + S  +  ++I++ ++ ++ +V+    +Q L +   + ++L+ + 
Sbjct: 840  LKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKML- 898

Query: 1417 KHGRSSKDKENAKSLDKPEQFLYELSLIPNFSERVFCILFQSTFSESICSIRRKLELLQK 1476
                 S+ K+    L + EQF   +  +P    R+  ILF+  FSE + +I+ ++  +  
Sbjct: 899  -----SELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTA 953

Query: 1477 LCETLKNGPGVMQVLGLVLAFGNYMNGGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLS 1536
             CE L+       +L + L  GNYMN G++  G A GF +  L KL+D KS+D   +LL 
Sbjct: 954  ACEELRKSESFSNLLEITLLVGNYMNAGSRNAG-AFGFNISFLCKLRDTKSTDQKMTLL- 1011

Query: 1537 YIVSYYLRNFDEDAGKEQCLFPLPEPQDLFQASQMKFEDFQKDLRKLKKDLKACEVEAGK 1596
                ++L    E+   +   FP  E   + +AS++  E+ QK+L ++KK +   +VE   
Sbjct: 1012 ----HFLAELCENDYPDVLKFP-DELAHVEKASRVSAENLQKNLDQMKKQIS--DVERDV 1064

Query: 1597 VYQVSSKEHMQPFKENMEQFIIQAKIDQEAEENSLTETHKCFLETTAYFFMKPKLGEKEV 1656
                ++ +    F E M  F+  A+          +     + E   YF   P    K++
Sbjct: 1065 QNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDP----KKL 1120

Query: 1657 SPNAFFSIWHEFSSDFKDFWKKENKLLLQERVKEAEEVCRQKK 1699
            S   FF   H F + F    K+  K       +E EE  R+ K
Sbjct: 1121 SVEEFFMDLHNFRNMFLQAVKENQKR------RETEEKMRRAK 1157



 Score =  224 bits (572), Expect = 4e-58
 Identities = 133/211 (63%), Positives = 141/211 (66%), Gaps = 22/211 (10%)

Query: 959  LPGAGIPLPPPLPG-AGIPPPPPLPGAG--IPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1015
            L  A I +PP +P  A +PP PPLPG    I PPPP PG    PPPP P    PPPPPLP
Sbjct: 556  LSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPP--PPPPPLP 613

Query: 1016 GAG-IPPPPPLPGA-GIPPPPPLPG-AGIPPPPPLP-GAGIPPPPPLP-GAGIPPPPPLP 1070
            G   I  PP LPG   I PPPPL G A IPPPPPLP G GIP P  LP G  IPPPPPLP
Sbjct: 614  GGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLP 673

Query: 1071 GAG--IPPPPPLPG-AGI-PPPPPLPG-AGI-PPPPPLP-GVGIPPPPPLPGA-GIPPPP 1122
            G+    PPPPPLPG AGI PPPPPLPG AG+ PPPPPLP G GIPPPPP PG  GIPPPP
Sbjct: 674  GSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPP 733

Query: 1123 PLPGAGIPPPPPLPGAGIPPPPPLPRVGIPP 1153
              PG G+PPPPP  G G+P  P LP  G+ P
Sbjct: 734  --PGMGMPPPPPF-GFGVPAAPVLP-FGLTP 760



 Score =  223 bits (567), Expect = 2e-57
 Identities = 138/235 (58%), Positives = 145/235 (61%), Gaps = 34/235 (14%)

Query: 937  LPGAGIPPPPPLPGAA-IPPPPPLPGAG---IPLPPPLPGAGIPPPPPLPGAGIPPPPPL 992
            L  A I  PP +P  A +PP PPLPG     IP PPP PG    PPPP       PPPP 
Sbjct: 556  LSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIP-PPPAPGDSTTPPPP-------PPPP- 606

Query: 993  PGAGIPPPPPLPGAG-IPPPPPLPGA-GIPPPPPLPG-AGIPPPPPLP-GAGIPPPPPLP 1048
                 PPPPPLPG   I  PP LPG   I PPPPL G A IPPPPPLP G GIP P  LP
Sbjct: 607  -----PPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLP 661

Query: 1049 GA-GIPPPPPLPGAGI--PPPPPLPG-AGIPPPPP-LPG-AGIPPPPP-LPGA-GIPPPP 1100
            G   IPPPPPLPG+    PPPPPLPG AGIPPPPP LPG AG+PPPPP LPG  GIPPPP
Sbjct: 662  GGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPP 721

Query: 1101 PLPG-VGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPP 1154
            P PG  GIPPPPP  G G+PPPPP  G G+P  P LP    P     P V +  P
Sbjct: 722  PFPGGPGIPPPPP--GMGMPPPPPF-GFGVPAAPVLPFGLTPKKLYKPEVQLRRP 773



 Score =  218 bits (555), Expect = 4e-56
 Identities = 130/213 (61%), Positives = 138/213 (64%), Gaps = 31/213 (14%)

Query: 912  PPPLPG-AGIPPPPPLPGAG--ILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPP 968
            PP +P  A +PP PPLPG    I+P PP PG    PPPP P    PPPPPLPG       
Sbjct: 564  PPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPP--PPPPPLPG------- 614

Query: 969  PLPGAGIPPPPPLPGA-GIPPPPPLPG-AGIPPPPPLP-GAGIPPPPPLP-GAGIPPPPP 1024
               G  I  PP LPG   I PPPPL G A IPPPPPLP G GIP P  LP G  IPPPPP
Sbjct: 615  ---GVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPP 671

Query: 1025 LPGAG--IPPPPPLPG-AGI-PPPPPLPG-AGI-PPPPPLPGA-GIPPPPPLPGA-GIPP 1076
            LPG+    PPPPPLPG AGI PPPPPLPG AG+ PPPPPLPG  GIPPPPP PG  GIPP
Sbjct: 672  LPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPP 731

Query: 1077 PPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPP 1109
            PP  PG G+PPPPP  G G+P  P LP  G+ P
Sbjct: 732  PP--PGMGMPPPPPF-GFGVPAAPVLP-FGLTP 760



 Score =  212 bits (539), Expect = 3e-54
 Identities = 127/207 (61%), Positives = 135/207 (65%), Gaps = 21/207 (10%)

Query: 890  TLPSTAIPQPPPLQGTEMLPPPPPPLPGAG--IPPPPPLPGAGILPLPPLPGAGIPPPPP 947
            +L + AI  PP +     +PP PP LPG    I PPPP PG    P PP P    PPPPP
Sbjct: 555  SLSAAAITVPPSVPSRAPVPPAPP-LPGDSGTIIPPPPAPGDSTTPPPPPPPP--PPPPP 611

Query: 948  LPGAA-IPPPPPLPGA-GIPLPPPLPG-AGIPPPPPLP-GAGIPPPPPLP-GAGIPPPPP 1002
            LPG   I  PP LPG   I  PPPL G A IPPPPPLP G GIP P  LP G  IPPPPP
Sbjct: 612  LPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPP 671

Query: 1003 LPGAG--IPPPPPLPG-AGI-PPPPPLPG-AGI-PPPPPLPGA-GIPPPPPLPGA-GIPP 1054
            LPG+    PPPPPLPG AGI PPPPPLPG AG+ PPPPPLPG  GIPPPPP PG  GIPP
Sbjct: 672  LPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPP 731

Query: 1055 PPPLPGAGIPPPPPLPGAGIPPPPPLP 1081
            PP  PG G+PPPPP  G G+P  P LP
Sbjct: 732  PP--PGMGMPPPPPF-GFGVPAAPVLP 755



 Score =  184 bits (467), Expect = 6e-46
 Identities = 108/196 (55%), Positives = 115/196 (58%), Gaps = 26/196 (13%)

Query: 855  IPSPPPLPCTESS----SSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPP 910
            +P  PPLP    +       PG    PPPPPP P    P      I  PP L G   + P
Sbjct: 573  VPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISP 632

Query: 911  PPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLP-GAAIPPPPPLPGAG--IPLP 967
            PPP    A IPPPPPLP           G GIP P  LP G AIPPPPPLPG+    P P
Sbjct: 633  PPPLSGDATIPPPPPLP----------EGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPP 682

Query: 968  PPLPG-AGI-PPPPPLPG-AGI-PPPPPLPGA-GIPPPPPLPGA-GIPPPPPLPGAGIPP 1021
            PPLPG AGI PPPPPLPG AG+ PPPPPLPG  GIPPPPP PG  GIPPPP  PG G+PP
Sbjct: 683  PPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPP--PGMGMPP 740

Query: 1022 PPPLPGAGIPPPPPLP 1037
            PPP  G G+P  P LP
Sbjct: 741  PPPF-GFGVPAAPVLP 755



 Score =  128 bits (321), Expect = 5e-29
 Identities = 119/363 (32%), Positives = 158/363 (43%), Gaps = 71/363 (19%)

Query: 632 PDEEHRLEDAETES--QSAVSETPQKRSDAVQKEVVDMKSEGQATVIQQLEQTIE----D 685
           PD + R    E E      + +T  ++S+A   E+ + K + + T   +L+  ++    D
Sbjct: 441 PDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAEL-EKKLDSELTARHELQVEMKKMESD 499

Query: 686 LRTKIAELERQYPALDTE---VASGHQGLENGVTA-SGDVCLEALRLEEKEVRHHRILEA 741
              K+ +L+ +  AL +E   +A+  Q LE  V+  +G+V      LE+ +       E 
Sbjct: 500 FEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKK------EM 553

Query: 742 KSIQTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSH 801
            S+  +       +T+PP   +P R P PP            +   I+ P       DS 
Sbjct: 554 ASLSAA------AITVPP--SVPSRAPVPPAPP------LPGDSGTIIPPP--PAPGDST 597

Query: 802 QPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPL 861
            P      PPPPP L        P S P  +           S          IP PPPL
Sbjct: 598 TPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAI---------SPPPPLSGDATIPPPPPL 648

Query: 862 P---CTESSSSMPGLGMVPPPPPPLPGMT-----VPTLPSTA--IPQPPPLQGTEMLPPP 911
           P      S SS+PG G   PPPPPLPG        P LP +A   P PPPL G   +PPP
Sbjct: 649 PEGVGIPSPSSLPG-GTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPP 707

Query: 912 PPPLP---GAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPP 968
           PPP     G GIPPPPP PG          G GIPPPP  PG  +PPPPP  G G+P  P
Sbjct: 708 PPP--LPGGPGIPPPPPFPG----------GPGIPPPP--PGMGMPPPPPF-GFGVPAAP 752

Query: 969 PLP 971
            LP
Sbjct: 753 VLP 755



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 70/316 (22%), Positives = 101/316 (31%), Gaps = 70/316 (22%)

Query: 629 SKPPDEEHRLEDAETESQSAVSETPQKRSDAVQKEVVDMKSEGQATVIQQLEQTIEDLRT 688
           +K  + E +L+   T       E  +  SD  QK + D++ E  A     L    + + T
Sbjct: 470 AKAAELEKKLDSELTARHELQVEMKKMESDFEQK-LQDLQGEKDA-----LHSEKQQIAT 523

Query: 689 KIAELERQYPALDTEVASGHQGLENGVTASGDVCLEALRLEEKEVRHHRILEAKSIQTSP 748
           +  +LE +   L  EVA   + LE+       +   A+ +         +  A  +   P
Sbjct: 524 EKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPL---P 580

Query: 749 TEEGGVLTLPPVDGLPGRPPCPP-----------------------GAESGPQTKFCSEI 785
            + G ++  PP  G    PP PP                       G    P      + 
Sbjct: 581 GDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDA 640

Query: 786 SLIVSP---RRISVQLDSHQP-----------TQSISQPPPPPSLLWSAG--------QG 823
           ++   P     + +   S  P             S   PPPPP L  SAG         G
Sbjct: 641 TIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPG 700

Query: 824 QPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTES-SSSMPGLGMVPPPPPP 882
           + G  PP                        IP PPP P         PG+GM PPPP  
Sbjct: 701 EAGMPPP---------------PPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFG 745

Query: 883 LPGMTVPTLPSTAIPQ 898
                 P LP    P+
Sbjct: 746 FGVPAAPVLPFGLTPK 761



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 54/217 (24%), Positives = 73/217 (33%), Gaps = 30/217 (13%)

Query: 189 ATEQEDLLSDIQQAIRLQQQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVS--PQPGAF 246
           ATE++DL +++ Q       +  +L  +L+  +++     A     PP+  S  P P A 
Sbjct: 522 ATEKQDLEAEVSQLTG----EVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPA- 576

Query: 247 LGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAPS 306
                 L G SG     P +P          D        P  P  PP PGG+ +S  PS
Sbjct: 577 ----PPLPGDSGTIIPPPPAP---------GDSTTPPPPPPPPPPPPPLPGGVCISSPPS 623

Query: 307 LPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEW 366
           LP     +   P S     P   P  E  G P      +            P   PG   
Sbjct: 624 LPGGTAISPPPPLSGDATIPPPPPLPEGVGIP------SPSSLPGGTAIPPPPPLPGSAR 677

Query: 367 APEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAP 403
            P      P   G  P      P  P  A +P  P P
Sbjct: 678 IPPPPPPLPGSAGIPPPP----PPLPGEAGMPPPPPP 710


>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
          Length = 1272

 Score =  317 bits (811), Expect = 8e-86
 Identities = 245/703 (34%), Positives = 339/703 (48%), Gaps = 129/703 (18%)

Query: 1025 LPGAGIPPPPPLPG-AGIPPPPPLPGAG--IPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1081
            L  A I  PP +P  A +PP PPLPG    I PPPP PG    PPPP       PPPP  
Sbjct: 565  LSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPP-------PPPP-- 615

Query: 1082 GAGIPPPPPLPGAG-IPPPPPLPG-VGIPPPPPLPG-AGIPPPPPLP-GAGIPPPPPLP- 1136
                PPPPPLPG   I  PP LPG   I PPPPL G A IPPPPPLP G GIP P  LP 
Sbjct: 616  ----PPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPG 671

Query: 1137 GAGIPPPPPLPRVG--IPPPPPLPG-AGI-PPPPPLPG-AGIPPPPPLPGVGIPPPPPLP 1191
            G  IPPPPPLP      PPPPPLPG AGI PPPPPLPG AG+P          PPPPPLP
Sbjct: 672  GTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMP----------PPPPPLP 721

Query: 1192 -GVGIPPPPPLPGA-GIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQV 1249
             G GIPPPPP PG  GIPPPP  PGMG+PP      PP G G+P  P+LP          
Sbjct: 722  GGPGIPPPPPFPGGPGIPPPP--PGMGMPPP-----PPFGFGVPAAPVLP---------- 764

Query: 1250 GSSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRIQLHSKRDS 1309
                                  FGL       + K+  +P   ++   W+++      D 
Sbjct: 765  ----------------------FGL-------TPKKLYKPEVQLRRPNWSKL---VAEDL 792

Query: 1310 STSLIWEKIEEPSIDCHEFEELFSK--------TAVKERKK-----PISDTISKTKAKQV 1356
            S    W K++E   D  E  ELF+K        T   + KK         ++ K K K+ 
Sbjct: 793  SQDCFWTKVKE---DRFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKE- 848

Query: 1357 VKLLSNKRSQAVGILMSSLHLDMKDIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIE 1416
            +K+L +K +Q + I + S  +  ++I++ ++ ++ +V+    +Q L +   + ++L+ + 
Sbjct: 849  LKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKML- 907

Query: 1417 KHGRSSKDKENAKSLDKPEQFLYELSLIPNFSERVFCILFQSTFSESICSIRRKLELLQK 1476
                 S+ K+    L + EQF   +  +P    R+  ILF+  FSE + +I+ ++  +  
Sbjct: 908  -----SELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTA 962

Query: 1477 LCETLKNGPGVMQVLGLVLAFGNYMNGGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLS 1536
             CE L+       +L + L  GNYMN G++  G A GF +  L KL+D KS+D   +LL 
Sbjct: 963  ACEELRKSESFSNLLEITLLVGNYMNAGSRNAG-AFGFNISFLCKLRDTKSTDQKMTLL- 1020

Query: 1537 YIVSYYLRNFDEDAGKEQCLFPLPEPQDLFQASQMKFEDFQKDLRKLKKDLKACEVEAGK 1596
                ++L    E+   +   FP  E   + +AS++  E+ QK+L ++KK +   +VE   
Sbjct: 1021 ----HFLAELCENDYPDVLKFP-DELAHVEKASRVSAENLQKNLDQMKKQIS--DVERDV 1073

Query: 1597 VYQVSSKEHMQPFKENMEQFIIQAKIDQEAEENSLTETHKCFLETTAYFFMKPKLGEKEV 1656
                ++ +    F E M  F+  A+          +     + E   YF   P    K++
Sbjct: 1074 QNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDP----KKL 1129

Query: 1657 SPNAFFSIWHEFSSDFKDFWKKENKLLLQERVKEAEEVCRQKK 1699
            S   FF   H F + F    K+  K       +E EE  R+ K
Sbjct: 1130 SVEEFFMDLHNFRNMFLQAVKENQKR------RETEEKMRRAK 1166



 Score =  224 bits (572), Expect = 4e-58
 Identities = 133/211 (63%), Positives = 141/211 (66%), Gaps = 22/211 (10%)

Query: 959  LPGAGIPLPPPLPG-AGIPPPPPLPGAG--IPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1015
            L  A I +PP +P  A +PP PPLPG    I PPPP PG    PPPP P    PPPPPLP
Sbjct: 565  LSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPP--PPPPPLP 622

Query: 1016 GAG-IPPPPPLPGA-GIPPPPPLPG-AGIPPPPPLP-GAGIPPPPPLP-GAGIPPPPPLP 1070
            G   I  PP LPG   I PPPPL G A IPPPPPLP G GIP P  LP G  IPPPPPLP
Sbjct: 623  GGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLP 682

Query: 1071 GAG--IPPPPPLPG-AGI-PPPPPLPG-AGI-PPPPPLP-GVGIPPPPPLPGA-GIPPPP 1122
            G+    PPPPPLPG AGI PPPPPLPG AG+ PPPPPLP G GIPPPPP PG  GIPPPP
Sbjct: 683  GSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPP 742

Query: 1123 PLPGAGIPPPPPLPGAGIPPPPPLPRVGIPP 1153
              PG G+PPPPP  G G+P  P LP  G+ P
Sbjct: 743  --PGMGMPPPPPF-GFGVPAAPVLP-FGLTP 769



 Score =  223 bits (567), Expect = 2e-57
 Identities = 138/235 (58%), Positives = 145/235 (61%), Gaps = 34/235 (14%)

Query: 937  LPGAGIPPPPPLPGAA-IPPPPPLPGAG---IPLPPPLPGAGIPPPPPLPGAGIPPPPPL 992
            L  A I  PP +P  A +PP PPLPG     IP PPP PG    PPPP       PPPP 
Sbjct: 565  LSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIP-PPPAPGDSTTPPPP-------PPPP- 615

Query: 993  PGAGIPPPPPLPGAG-IPPPPPLPGA-GIPPPPPLPG-AGIPPPPPLP-GAGIPPPPPLP 1048
                 PPPPPLPG   I  PP LPG   I PPPPL G A IPPPPPLP G GIP P  LP
Sbjct: 616  -----PPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLP 670

Query: 1049 GA-GIPPPPPLPGAGI--PPPPPLPG-AGIPPPPP-LPG-AGIPPPPP-LPGA-GIPPPP 1100
            G   IPPPPPLPG+    PPPPPLPG AGIPPPPP LPG AG+PPPPP LPG  GIPPPP
Sbjct: 671  GGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPP 730

Query: 1101 PLPG-VGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPP 1154
            P PG  GIPPPPP  G G+PPPPP  G G+P  P LP    P     P V +  P
Sbjct: 731  PFPGGPGIPPPPP--GMGMPPPPPF-GFGVPAAPVLPFGLTPKKLYKPEVQLRRP 782



 Score =  218 bits (555), Expect = 4e-56
 Identities = 130/213 (61%), Positives = 138/213 (64%), Gaps = 31/213 (14%)

Query: 912  PPPLPG-AGIPPPPPLPGAG--ILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPP 968
            PP +P  A +PP PPLPG    I+P PP PG    PPPP P    PPPPPLPG       
Sbjct: 573  PPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPP--PPPPPLPG------- 623

Query: 969  PLPGAGIPPPPPLPGA-GIPPPPPLPG-AGIPPPPPLP-GAGIPPPPPLP-GAGIPPPPP 1024
               G  I  PP LPG   I PPPPL G A IPPPPPLP G GIP P  LP G  IPPPPP
Sbjct: 624  ---GVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPP 680

Query: 1025 LPGAG--IPPPPPLPG-AGI-PPPPPLPG-AGI-PPPPPLPGA-GIPPPPPLPGA-GIPP 1076
            LPG+    PPPPPLPG AGI PPPPPLPG AG+ PPPPPLPG  GIPPPPP PG  GIPP
Sbjct: 681  LPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPP 740

Query: 1077 PPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPP 1109
            PP  PG G+PPPPP  G G+P  P LP  G+ P
Sbjct: 741  PP--PGMGMPPPPPF-GFGVPAAPVLP-FGLTP 769



 Score =  212 bits (539), Expect = 3e-54
 Identities = 127/207 (61%), Positives = 135/207 (65%), Gaps = 21/207 (10%)

Query: 890  TLPSTAIPQPPPLQGTEMLPPPPPPLPGAG--IPPPPPLPGAGILPLPPLPGAGIPPPPP 947
            +L + AI  PP +     +PP PP LPG    I PPPP PG    P PP P    PPPPP
Sbjct: 564  SLSAAAITVPPSVPSRAPVPPAPP-LPGDSGTIIPPPPAPGDSTTPPPPPPPP--PPPPP 620

Query: 948  LPGAA-IPPPPPLPGA-GIPLPPPLPG-AGIPPPPPLP-GAGIPPPPPLP-GAGIPPPPP 1002
            LPG   I  PP LPG   I  PPPL G A IPPPPPLP G GIP P  LP G  IPPPPP
Sbjct: 621  LPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPP 680

Query: 1003 LPGAG--IPPPPPLPG-AGI-PPPPPLPG-AGI-PPPPPLPGA-GIPPPPPLPGA-GIPP 1054
            LPG+    PPPPPLPG AGI PPPPPLPG AG+ PPPPPLPG  GIPPPPP PG  GIPP
Sbjct: 681  LPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPP 740

Query: 1055 PPPLPGAGIPPPPPLPGAGIPPPPPLP 1081
            PP  PG G+PPPPP  G G+P  P LP
Sbjct: 741  PP--PGMGMPPPPPF-GFGVPAAPVLP 764



 Score =  184 bits (467), Expect = 6e-46
 Identities = 108/196 (55%), Positives = 115/196 (58%), Gaps = 26/196 (13%)

Query: 855  IPSPPPLPCTESS----SSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPP 910
            +P  PPLP    +       PG    PPPPPP P    P      I  PP L G   + P
Sbjct: 582  VPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISP 641

Query: 911  PPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLP-GAAIPPPPPLPGAG--IPLP 967
            PPP    A IPPPPPLP           G GIP P  LP G AIPPPPPLPG+    P P
Sbjct: 642  PPPLSGDATIPPPPPLP----------EGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPP 691

Query: 968  PPLPG-AGI-PPPPPLPG-AGI-PPPPPLPGA-GIPPPPPLPGA-GIPPPPPLPGAGIPP 1021
            PPLPG AGI PPPPPLPG AG+ PPPPPLPG  GIPPPPP PG  GIPPPP  PG G+PP
Sbjct: 692  PPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPP--PGMGMPP 749

Query: 1022 PPPLPGAGIPPPPPLP 1037
            PPP  G G+P  P LP
Sbjct: 750  PPPF-GFGVPAAPVLP 764



 Score =  128 bits (321), Expect = 5e-29
 Identities = 119/363 (32%), Positives = 158/363 (43%), Gaps = 71/363 (19%)

Query: 632 PDEEHRLEDAETES--QSAVSETPQKRSDAVQKEVVDMKSEGQATVIQQLEQTIE----D 685
           PD + R    E E      + +T  ++S+A   E+ + K + + T   +L+  ++    D
Sbjct: 450 PDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAEL-EKKLDSELTARHELQVEMKKMESD 508

Query: 686 LRTKIAELERQYPALDTE---VASGHQGLENGVTA-SGDVCLEALRLEEKEVRHHRILEA 741
              K+ +L+ +  AL +E   +A+  Q LE  V+  +G+V      LE+ +       E 
Sbjct: 509 FEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKK------EM 562

Query: 742 KSIQTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSH 801
            S+  +       +T+PP   +P R P PP            +   I+ P       DS 
Sbjct: 563 ASLSAA------AITVPP--SVPSRAPVPPAPP------LPGDSGTIIPPP--PAPGDST 606

Query: 802 QPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPL 861
            P      PPPPP L        P S P  +           S          IP PPPL
Sbjct: 607 TPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAI---------SPPPPLSGDATIPPPPPL 657

Query: 862 P---CTESSSSMPGLGMVPPPPPPLPGMT-----VPTLPSTA--IPQPPPLQGTEMLPPP 911
           P      S SS+PG G   PPPPPLPG        P LP +A   P PPPL G   +PPP
Sbjct: 658 PEGVGIPSPSSLPG-GTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPP 716

Query: 912 PPPLP---GAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPP 968
           PPP     G GIPPPPP PG          G GIPPPP  PG  +PPPPP  G G+P  P
Sbjct: 717 PPP--LPGGPGIPPPPPFPG----------GPGIPPPP--PGMGMPPPPPF-GFGVPAAP 761

Query: 969 PLP 971
            LP
Sbjct: 762 VLP 764



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 70/316 (22%), Positives = 101/316 (31%), Gaps = 70/316 (22%)

Query: 629 SKPPDEEHRLEDAETESQSAVSETPQKRSDAVQKEVVDMKSEGQATVIQQLEQTIEDLRT 688
           +K  + E +L+   T       E  +  SD  QK + D++ E  A     L    + + T
Sbjct: 479 AKAAELEKKLDSELTARHELQVEMKKMESDFEQK-LQDLQGEKDA-----LHSEKQQIAT 532

Query: 689 KIAELERQYPALDTEVASGHQGLENGVTASGDVCLEALRLEEKEVRHHRILEAKSIQTSP 748
           +  +LE +   L  EVA   + LE+       +   A+ +         +  A  +   P
Sbjct: 533 EKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPL---P 589

Query: 749 TEEGGVLTLPPVDGLPGRPPCPP-----------------------GAESGPQTKFCSEI 785
            + G ++  PP  G    PP PP                       G    P      + 
Sbjct: 590 GDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDA 649

Query: 786 SLIVSP---RRISVQLDSHQP-----------TQSISQPPPPPSLLWSAG--------QG 823
           ++   P     + +   S  P             S   PPPPP L  SAG         G
Sbjct: 650 TIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPG 709

Query: 824 QPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTES-SSSMPGLGMVPPPPPP 882
           + G  PP                        IP PPP P         PG+GM PPPP  
Sbjct: 710 EAGMPPP---------------PPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFG 754

Query: 883 LPGMTVPTLPSTAIPQ 898
                 P LP    P+
Sbjct: 755 FGVPAAPVLPFGLTPK 770



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 54/217 (24%), Positives = 73/217 (33%), Gaps = 30/217 (13%)

Query: 189 ATEQEDLLSDIQQAIRLQQQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVS--PQPGAF 246
           ATE++DL +++ Q       +  +L  +L+  +++     A     PP+  S  P P A 
Sbjct: 531 ATEKQDLEAEVSQLTG----EVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPA- 585

Query: 247 LGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAPS 306
                 L G SG     P +P          D        P  P  PP PGG+ +S  PS
Sbjct: 586 ----PPLPGDSGTIIPPPPAP---------GDSTTPPPPPPPPPPPPPLPGGVCISSPPS 632

Query: 307 LPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEW 366
           LP     +   P S     P   P  E  G P      +            P   PG   
Sbjct: 633 LPGGTAISPPPPLSGDATIPPPPPLPEGVGIP------SPSSLPGGTAIPPPPPLPGSAR 686

Query: 367 APEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAP 403
            P      P   G  P      P  P  A +P  P P
Sbjct: 687 IPPPPPPLPGSAGIPPPP----PPLPGEAGMPPPPPP 719


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  196 bits (497), Expect = 2e-49
 Identities = 274/984 (27%), Positives = 357/984 (36%), Gaps = 156/984 (15%)

Query: 398  PGSPAPSQRCFKPYPLITPCYIKTTTRQLSSPNHSPS-QSPNQSPRIKRRPEPSLSRGSR 456
            P SPA +    K  P + P          ++P +SPS QS + SP I   PE +L++ S 
Sbjct: 543  PFSPAQAGLTTKKDPTVLPLV-------QAAPKNSPSFQSTSSSPEIPLSPEATLAKKSL 595

Query: 457  TALASVAAPAKKHRADGGLAAGLSRSADWTEELGARTPRVGGSAHLLERGVASDSGGGVS 516
                 +  PA    +      G++ SA   +      P   G   LL+  + + +     
Sbjct: 596  GEPLPIGKPASSMTSP----LGVNSSASVIKTDSYAGPDSAGP--LLKSSLITPTVAAFP 649

Query: 517  PALAAKASGAPAAADGFQN-VFTGRTLLEKLFS-QQENGPPEEAEKFCSRIIAMGLLLPF 574
               A  A  AP  A G      T    LE   S   +N P +E       ++        
Sbjct: 650  LESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTAS---- 705

Query: 575  SDCFREPCNQNAQTNAASFDQDQLYTWAAVSQPTHSLDYSEGQFPRRVPSMG-PPSKPPD 633
             +C   P  QN     A+           V  P         + P+ VPS   PP+  P 
Sbjct: 706  ENCPVAPSPQNTCAPLATL----------VLAP---------EIPKSVPSPSLPPAGTPP 746

Query: 634  EEHRLED-AETESQSAVSETPQKRSDAVQKEVVDMKSEGQATVIQQLEQTIEDLRTKIAE 692
               +++  + T + + V+ +P++             S+G  T    L  +   L   ++ 
Sbjct: 747  GTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTY---LADSPSPLGVSVSP 803

Query: 693  LERQYPALDTEVASGHQGLENGVTASGDVCLEALRLEEKEVRHHRILEAKSIQTSPTEEG 752
              ++ P   T+  S       G  +S    +EA  L E  +      ++ +   SPT   
Sbjct: 804  QTKRPP---TKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPT--- 857

Query: 753  GVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPP 812
                          PP P GA +       S   + + P+          PT S+   P 
Sbjct: 858  --------------PPSPKGAPTPSAVTPLSPKGVTLPPKET--------PTPSVVNLPF 895

Query: 813  PPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPG 872
            P       G   P  +   ++S           SS+ K +   P+P  +P + S    P 
Sbjct: 896  PKE-----GPATPAPKQAPALSM---------TSSSPKKARATPAPKGIPASPSPKGAP- 940

Query: 873  LGMVPP---PPPPLPGMTVPT---LPSTAIPQPPPLQGTEMLPPPP-PPLPGAGIPPPPP 925
                PP   PP P  G   P+    P+     PP  +G    P P   P P A  PP P 
Sbjct: 941  ---TPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPK 997

Query: 926  LPGAGILPLP---PLPGAGIPPPP-------PLPGAAIPPP---PPLPGAGIPLPPPLP- 971
              G    P P   P P A  PP P       P P  A  PP   PP P  G P   PLP 
Sbjct: 998  --GGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSP-KGSPAATPLPK 1054

Query: 972  GAGIPPPPPLPG-AGIPPPPPLPGAGIPP--PPPLPGAGIPPPPPLPGAGIPP--PPPLP 1026
            GA   P   LP   G P  P L GA  PP   PP P  G P  P   GA +PP   PP P
Sbjct: 1055 GAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGG-PATPSPKGAPMPPAATPPSP 1113

Query: 1027 GAGIPPPPPLPGAGIPP--PPPLPGAGIPPPPPLPGAGIPP--PPPLPGAGIPPPPPLPG 1082
              G+  PP   GA   P   PP P  G+  PPP  GA   P   PP P  G+  PPP  G
Sbjct: 1114 KGGLATPPH-KGAPTTPAATPPSPKGGLATPPP-KGAPTTPAATPPSPKGGLATPPP-KG 1170

Query: 1083 AGIPP--PPPLPGAGIPPPPPLPGVGIP---PPPPLPGAGIPPP---PPLPGAGIPPPPP 1134
            A   P   PP P  G+  P P      P   PP P  G   P P   P  P A   PP P
Sbjct: 1171 APTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAA--TPPSP 1228

Query: 1135 LPGAGIPPPPPLPRV-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPP----P 1189
              G   P P   P      PP P  G   PPP   P      PP L G G+  PP    P
Sbjct: 1229 KGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKG-GLATPPHKGAP 1287

Query: 1190 LPGVGIPPPPPLPGAGIPPP--PPLPGMGIPPAP--APPLPPPGTGIPPPPLLPVS--GP 1243
             P V + PP P  G    PP   P P    PP+P  +P  PPP     PP + P S  G 
Sbjct: 1288 NPAV-VTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGT 1346

Query: 1244 PLLPQV-----GSSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYW 1298
            P LP       G  T P+ +     P   PS   G  M      ++ P  P     P   
Sbjct: 1347 PTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMT-PPSPKRGPAIPSPKGDPTSP 1405

Query: 1299 TRIQLHSKRDSSTSLIWEKIEEPS 1322
              I L  K+  +T +  E    PS
Sbjct: 1406 AVIPLSPKKAPATPVTREGAATPS 1429



 Score =  171 bits (433), Expect = 6e-42
 Identities = 178/575 (30%), Positives = 205/575 (35%), Gaps = 114/575 (19%)

Query: 746  TSPTEEGGVLTLPPVDGLPGRPPC-PPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPT 804
            T P+ +GG  T P   G P  P   PP  + GP T          SP+            
Sbjct: 969  TPPSPKGGPAT-PSPKGAPTPPAATPPSPKGGPATP---------SPK------------ 1006

Query: 805  QSISQPPPPPSLLWSAGQGQPGSQP-PHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPC 863
                  P PP++   + +G P + P P   ST                       PP   
Sbjct: 1007 ----GAPTPPAVTPPSPKGSPAATPFPKGAST-----------------------PPAAT 1039

Query: 864  TESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPP 923
              S    P    +P   P  P  T+P+      P  P L+G    P   PP P  G P  
Sbjct: 1040 PPSPKGSPAATPLPKGAPTTPAATLPS--PKGGPATPSLKGAPTPPAATPPSPKGG-PAT 1096

Query: 924  PPLPGAGILP--LPPLPGAGIPPPPPLPGAAIP-PPPPLPGAGIPLPPPLPGAGIPP--P 978
            P   GA + P   PP P  G+  PP       P   PP P  G+  PPP  GA   P   
Sbjct: 1097 PSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPP-KGAPTTPAAT 1155

Query: 979  PPLPGAGIPPPPPLPGAGIPP--PPPLPGAGIPPPPPLPGAGIPP--PPPLPGAGIPPPP 1034
            PP P  G+  PPP  GA   P   PP P  G+  P P  GA   P   PP P  G+  P 
Sbjct: 1156 PPSPKGGLATPPP-KGAPTTPAATPPSPKGGLATPSP-KGAPTTPAATPPSPKGGLATPS 1213

Query: 1035 PLPGAGIPP--PPPLPGAGIPPPPPLPGAGIP---PPPPLPGAGIPPPPPLPGAGIPPPP 1089
            P  GA   P   PP P  G+  P P      P   PP P  G   PPP   P      PP
Sbjct: 1214 P-KGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPP 1272

Query: 1090 PLPGAGIPPP---PPLPGVGIPPPP-------PLPGAGIPP--PPPLPGAGIPPPPPLPG 1137
             L G    PP    P P V  PP P       P  GA  PP   PP P  G P  PP  G
Sbjct: 1273 SLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSP-KGSPGTPPPKG 1331

Query: 1138 AGIPP--PPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP----GVGIPPPPPLP 1191
            A  PP   PP P+     P   P +   P  P    G  PP   P    G  + PP P  
Sbjct: 1332 APTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKR 1391

Query: 1192 GVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTGIP------PPPLLPVS---- 1241
            G  IP P      G P  P +  +    APA P+   G   P      PP + PVS    
Sbjct: 1392 GPAIPSP-----KGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKA 1446

Query: 1242 --------GPPLLPQVGSSTLPTPQVCGFLPPPLP 1268
                    GP      G  TLP         PP P
Sbjct: 1447 PATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAP 1481



 Score =  137 bits (344), Expect = 1e-31
 Identities = 193/680 (28%), Positives = 231/680 (33%), Gaps = 142/680 (20%)

Query: 746  TSPTEEGGVLTLPPVDGLP----GRPPCPPGAESGPQTKFCSEISLIVSPRR---ISVQL 798
            T P+ +GG  T P + G P      PP P G  + P  K          P     ++   
Sbjct: 1063 TLPSPKGGPAT-PSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPP 1121

Query: 799  DSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSP 858
                PT   + PP P        +G   + PP    T        +   + K     P P
Sbjct: 1122 HKGAPTTPAATPPSP--------KGGLATPPPKGAPTT-----PAATPPSPKGGLATPPP 1168

Query: 859  PPLPCTESSSS-MPGLGMVPPPP---PPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPP 914
               P T +++   P  G+  P P   P  P  T P+ P   +  P P +G    P   PP
Sbjct: 1169 KGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPS-PKGGLATPSP-KGAPTTPAATPP 1226

Query: 915  LPGAGIPPPPPLPGAGILPL--PPLPGAGIPPPPPLPGAAIPP---PPPLPGAGIPLPP- 968
             P  G+  P P  GA   P   PP P  G   PPP  GA  PP   PP L G G+  PP 
Sbjct: 1227 SPKGGLATPSP-KGAPTTPAATPPSPKGGPATPPP-KGAPTPPAATPPSLKG-GLATPPH 1283

Query: 969  ---PLPGAGIPPPPPLPGAGIPPP--PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP-- 1021
               P P A + PP P  G    PP   P P A  PP P     G P  PP  GA  PP  
Sbjct: 1284 KGAPNP-AVVTPPSPKGGPATSPPKGAPTPPAATPPSP----KGSPGTPPPKGAPTPPAV 1338

Query: 1022 PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP----GAGIPPPPPLPGAGIPPP 1077
             PP P      P   P +   P  P    G  PP   P    G  + PP P  G  IP P
Sbjct: 1339 TPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSP 1398

Query: 1078 --PPLPGAGIP------PPPPL-------PGAGIPPPPPLPGVGIPPPP----PLPGAGI 1118
               P   A IP      P  P+       P  G   PP +  V +   P    P  G   
Sbjct: 1399 KGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPAT 1458

Query: 1119 PP---PPPLPGAGIPPP--PPLP-----------GAGIPPP---PPLPRVGIPPPPPLPG 1159
            P     P LP    P P  PP P               P P   P LP V    P  +P 
Sbjct: 1459 PSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPA 1518

Query: 1160 ----------------------------AGIPP----PPPLPGAGIPPPPPLPGV----- 1182
                                        A IPP    P P     IP P   P       
Sbjct: 1519 TPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKE 1578

Query: 1183 GIPPPPPLPGV--GIPPPPPL---PGAGIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPL 1237
               PP   P    G P P  L   P    P P   P    PPA  PP P  G   P P  
Sbjct: 1579 ASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAP---TPPAVTPPSPEKGPATPAPKG 1635

Query: 1238 LPVSGPPLLPQ--VGSSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGSRKQP-IEPCRPMK 1294
             P S PP+ P     S T P    C  +   +P    GL   +   + K+  + P     
Sbjct: 1636 TPTS-PPVTPSSLKDSPTSPASVTCK-MGATVPQASKGLPAKKGPTALKEVLVAPAPEST 1693

Query: 1295 PLYW--TRIQLHSKRDSSTS 1312
            P+    TR    +K+ S+TS
Sbjct: 1694 PIITAPTRKGPQTKKSSATS 1713



 Score =  103 bits (258), Expect = 1e-21
 Identities = 151/622 (24%), Positives = 202/622 (32%), Gaps = 91/622 (14%)

Query: 736  HRILEAKSIQTSPTEEGGVLTLPPVDGLP----GRPPCPPGAESGPQTKFCSEISLIVSP 791
            H+     ++ T P+ +GG  T PP  G P      PP P G+   P  K       +  P
Sbjct: 1283 HKGAPNPAVVTPPSPKGGPATSPP-KGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPP 1341

Query: 792  RR-------ISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHS 844
                      +       PT   S+  P P     + +G P   PP         S +  
Sbjct: 1342 SPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGD 1401

Query: 845  VSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQ----PP 900
             +S      +    P  P T   ++ P  G + PP   +  +++   P+T+ P+     P
Sbjct: 1402 PTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPA--VTPVSLKKAPATSAPKGGPATP 1459

Query: 901  PLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPP---PPLPGAAIPPPP 957
              +G   LP   PP P       PP P        P      P P   P LP A IP  P
Sbjct: 1460 SSKGDPTLPAVTPPSP-----KEPPAPKQVATSSSPKKAPATPAPMGAPTLP-AVIPSSP 1513

Query: 958  PLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA 1017
                  +P  P      I P   L     P       A IPP   +P     P  P P  
Sbjct: 1514 K----EVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKE 1569

Query: 1018 GIPPPPPLPGAGIPPPPPLPGAGIPPP-----PPLPGAGIPPPPPLPGAGIPPPP----- 1067
                P     +  P   P    G P P     PP   +  P   P P A  PP P     
Sbjct: 1570 APATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPA 1629

Query: 1068 -PLPGAGIPPPPPLPGAGIPPPPPLPGA---GIPPPPPLPGVGIPP---PPPLPGAGIPP 1120
             P P  G P  PP+  + +   P  P +    +    P    G+P    P  L    + P
Sbjct: 1630 TPAP-KGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAP 1688

Query: 1121 PP---PLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLP-------- 1169
             P   P+  A     P    +    PP  P          P + + P P LP        
Sbjct: 1689 APESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKT 1748

Query: 1170 ----GAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIP--PAPAP 1223
                 A   P  PL         PL         P P +      P P + +P  P+P P
Sbjct: 1749 AKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVP 1808

Query: 1224 PLPP--------PGTGI--PPPPLLPVSGPPLLPQVGSS-------------TLPTPQVC 1260
             LPP        PG  +  P  PL P     LLP +                 +PTP+  
Sbjct: 1809 TLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSA 1868

Query: 1261 GFLPPPLPSGLFGLGMNQDKGS 1282
            G +P P PS    +  N +KGS
Sbjct: 1869 G-IPVPTPSAKQPVTKN-NKGS 1888



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 182/724 (25%), Positives = 220/724 (30%), Gaps = 245/724 (33%)

Query: 768  PCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGS 827
            PC   A   P T F  E++  VSP   S  + + +PT   +    P +            
Sbjct: 446  PCTIAA--APTTTF--EVATCVSPPMSSGPISNIEPTSPAALVMAPVA------------ 489

Query: 828  QPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPP-------- 879
              P   ST+  T+              IP  PPLP  E   ++P   +V  P        
Sbjct: 490  --PKEPSTQVATT------------LRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTV 535

Query: 880  PPPLPGM---------------TVPTLPSTAIPQPPPLQGTEMLPPPP------------ 912
            P  L G                TV  L   A    P  Q T   P  P            
Sbjct: 536  PASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSL 595

Query: 913  -PPLP-------------------------GAGIPPPPPL-------PGAGILPLPPLPG 939
              PLP                          AG     PL       P     PL     
Sbjct: 596  GEPLPIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADP 655

Query: 940  AGIPP-------------PPPLPG--AAIPPPPPLPGAGIPLPPPLPGAG----IPPPPP 980
            AG+ P              P L G  +  P   P+    +   P +P A     + P P 
Sbjct: 656  AGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQ 715

Query: 981  ---LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP-----------LPGAGIPPPPPLP 1026
                P A +   P +P +   P P LP AG PP               P A  P   P  
Sbjct: 716  NTCAPLATLVLAPEIPKS--VPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTE 773

Query: 1027 GAG--------------IPPPPPLPGAGIPP----PPPLPGAGIPPPP---------PLP 1059
             +G                 P PL G  + P    PP   G+  P  P         P+ 
Sbjct: 774  DSGASATASSKGTLTYLADSPSPL-GVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVE 832

Query: 1060 GAGIP------------------PPPPLPGAGIPPP---PPLPGAGIPPPP--------- 1089
             + +P                  P PP P  G P P    PL   G+  PP         
Sbjct: 833  ASFLPENSLSFQGSKDSPATTHSPTPPSP-KGAPTPSAVTPLSPKGVTLPPKETPTPSVV 891

Query: 1090 ----PLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP- 1144
                P  G   P P   P + +    P      P P  +P +  P   P P A  PP P 
Sbjct: 892  NLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPK 951

Query: 1145 -----------PLPRVGIPPPP------------PLPGAGIPPPP------PLP-GAGIP 1174
                       P P    PP P            P P A  PP P      P P GA  P
Sbjct: 952  GGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTP 1011

Query: 1175 P--PPPLPGVGIPPPPPLP-GVGIPP--PPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPG 1229
            P   PP P  G P   P P G   PP   PP P  G P   PLP  G P  PA  LP P 
Sbjct: 1012 PAVTPPSP-KGSPAATPFPKGASTPPAATPPSP-KGSPAATPLP-KGAPTTPAATLPSPK 1068

Query: 1230 TGIPPPPL----LPVSGPPLLPQVGSSTLPTPQVCGFLP---PPLPSGLFGLGMNQDKGS 1282
             G   P L     P +  P  P+ G +T P+P+     P   PP P G  GL     KG+
Sbjct: 1069 GGPATPSLKGAPTPPAATPPSPKGGPAT-PSPKGAPMPPAATPPSPKG--GLATPPHKGA 1125

Query: 1283 RKQP 1286
               P
Sbjct: 1126 PTTP 1129



 Score = 68.2 bits (165), Expect = 7e-11
 Identities = 175/804 (21%), Positives = 262/804 (32%), Gaps = 128/804 (15%)

Query: 236  PTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQ---Q 292
            P A  P P   L        P+  A   P SP    A  +    P + AA P  P+    
Sbjct: 1152 PAATPPSPKGGLATPPPKGAPTTPAATPP-SPKGGLATPSPKGAPTTPAATPPSPKGGLA 1210

Query: 293  PPSPGGLPVSEAPSLPA-----AQPAAKDSPSSTAF--PFPEAGPGEEAAGAPVRGAGDT 345
             PSP G P + A + P+     A P+ K +P++ A   P P+ GP    A  P +GA  T
Sbjct: 1211 TPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGP----ATPPPKGA-PT 1265

Query: 346  DEEGEEDAFEDAPRGSPGEEWAPEVG-EDAPQRLGEEPEEEAQGPDAPAAASLP---GSP 401
                   + +     +P  + AP       P   G       +G   P AA+ P   GSP
Sbjct: 1266 PPAATPPSLKGG-LATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSP 1324

Query: 402  -APSQRCFKPYPLITPCYIK-TTTRQLSSPNHSPSQSPNQSPRIKRRPEPSLSRGSRTAL 459
              P  +     P +TP   K T T   ++P+   S+    +P  K  P P  +  S    
Sbjct: 1325 GTPPPKGAPTPPAVTPPSPKGTPTLPATTPS---SKGGPTTPSSKEGPTPPAATPSHKGG 1381

Query: 460  ASVAAPAKKHRADGGLAAGLSRSADWTEELGARTPRVGGSAHLLERGVASDSGGGVSPAL 519
             ++  P+ K     G A    +    +  +   +P+   +  +   G A+ S G ++P  
Sbjct: 1382 PAMTPPSPKR----GPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPA 1437

Query: 520  AAKASGAPAAADGFQNVFTGRTLLEKLFSQQENGPPEEAEKFCSRIIAMGLLLPFSDCFR 579
                S   A A                 S  + GP   + K    + A+           
Sbjct: 1438 VTPVSLKKAPAT----------------SAPKGGPATPSSKGDPTLPAV----------- 1470

Query: 580  EPCNQNAQTNAASFDQDQLYTWAAVSQPTHSLDYSEGQFPRRVPSMGPPSKPPDEEHRLE 639
                                T  +  +P      +    P++ P+   P   P     L 
Sbjct: 1471 --------------------TPPSPKEPPAPKQVATSSSPKKAPATPAPMGAP----TLP 1506

Query: 640  DAETESQSAVSETPQKRSDAVQKEVVDMKSEGQATVIQQLEQTIEDLRTKIAELERQYPA 699
                 S   V  TP  R D +      +  +  AT+  + E  I    T      ++ PA
Sbjct: 1507 AVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPK-EALIPPAMT--VPSPKKTPA 1563

Query: 700  LDTEVASGHQGLENGVTASGDVCLEALR--LEEKEVRHHRILEAKSIQTSPTEEGGVLTL 757
            + T   +         ++   V     +     KE+     + + S + +PT        
Sbjct: 1564 IPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPA---VT 1620

Query: 758  PPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQP------- 810
            PP        P P G  + P     S      SP  ++ ++ +  P  S   P       
Sbjct: 1621 PPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTA 1680

Query: 811  -------PPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPC 863
                   P P S        + G Q   S +T      + S  +  K   +  +P PL  
Sbjct: 1681 LKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLP 1740

Query: 864  TESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPP 923
             +  SS    G      P   G   P  P +    P      E + P P     +  P P
Sbjct: 1741 VQKDSSKTAKGKDASHSP--KGPLAP--PESKASTPLTAAAFEKVLPKPESASVSAAPSP 1796

Query: 924  PPLPGAGILPLPPLPGAGIPPP----PPLPGAAI-PPPPPLPGAG----IPLPPPLPGAG 974
            P       LPL P P   +PP     P  PG  +  P  PL  A     +PL PP P +G
Sbjct: 1797 PV-----SLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISG 1851

Query: 975  IPP-------PPPLPGAGIPPPPP 991
              P        P    AGIP P P
Sbjct: 1852 GVPFQSVLVNMPTPKSAGIPVPTP 1875



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 53/190 (27%), Positives = 75/190 (39%), Gaps = 34/190 (17%)

Query: 262  EAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSE----APSLPAAQPAAKDS 317
            E P +P  +QA  ALS      ++ P++ +  P+P G+P S     AP+ PAA P +   
Sbjct: 898  EGPATPAPKQA-PALS----MTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKG 952

Query: 318  PSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQR 377
              +T  P P+  P   AA  P                  +P+G P    A    + AP  
Sbjct: 953  GPAT--PSPKWAPTPPAATPP------------------SPKGGP----ATPSPKGAPTP 988

Query: 378  LGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSSPNHSPSQSP 437
                P     GP  P+    P  PA +    K  P  TP     +T   ++P  SP  SP
Sbjct: 989  PAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATP-PSPKGSP 1047

Query: 438  NQSPRIKRRP 447
              +P  K  P
Sbjct: 1048 AATPLPKGAP 1057



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 72/279 (25%), Positives = 92/279 (32%), Gaps = 35/279 (12%)

Query: 262  EAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEA-----PSLPAAQPAAKD 316
            EA   P+   +     D P    A    P  PPSP G P   A     P      P    
Sbjct: 832  EASFLPENSLSFQGSKDSP----ATTHSPT-PPSPKGAPTPSAVTPLSPKGVTLPPKETP 886

Query: 317  SPSSTAFPFPEAGPGEEA-AGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAP 375
            +PS    PFP+ GP   A   AP      T    ++     AP+G P    A    + AP
Sbjct: 887  TPSVVNLPFPKEGPATPAPKQAPALSM--TSSSPKKARATPAPKGIP----ASPSPKGAP 940

Query: 376  QRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSSPNHSPSQ 435
                  P     GP  P+    P  PA +    K  P  TP           SP  +P+ 
Sbjct: 941  TPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGP-ATP-----------SPKGAPTP 988

Query: 436  SPNQSPRIKRRPEPSLSRGSRTALASVAAPAKKHRADGGLAAGLSRSADWT----EELGA 491
                 P  K  P     +G+ T  A      K   A      G S     T    +   A
Sbjct: 989  PAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPA 1048

Query: 492  RTPRVGGSAHLLERGVASDSGGGVSPALAAKASGAPAAA 530
             TP   G+       + S  GG  +P+L  K +  P AA
Sbjct: 1049 ATPLPKGAPTTPAATLPSPKGGPATPSL--KGAPTPPAA 1085



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 76/313 (24%), Positives = 103/313 (32%), Gaps = 49/313 (15%)

Query: 235  PPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPP 294
            PP A  P P            P+  A   P SP    A  +    P   A  P  P+  P
Sbjct: 965  PPAATPPSPKGGPATPSPKGAPTPPAATPP-SPKGGPATPSPKGAPTPPAVTPPSPKGSP 1023

Query: 295  SPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAF 354
            +    P   +    A  P+ K SP++T  P P+  P   AA  P                
Sbjct: 1024 AATPFPKGASTPPAATPPSPKGSPAAT--PLPKGAPTTPAATLP---------------- 1065

Query: 355  EDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYP-- 412
              +P+G P     P + + AP      P     GP  P+    P  PA +     P P  
Sbjct: 1066 --SPKGGPA---TPSL-KGAPTPPAATPPSPKGGPATPSPKGAPMPPAAT----PPSPKG 1115

Query: 413  -LITPCYIKTTTRQLSSPNHSP-----SQSPNQSPRIKRRPEPSLSRGSRTAL---ASVA 463
             L TP +    T   ++P  SP     +  P  +P       PS   G  T     A   
Sbjct: 1116 GLATPPHKGAPTTPAATP-PSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTT 1174

Query: 464  APAKKHRADGGLAAGLSRSADWTEELGARTPRVGGSAHLLERGVASDSG-------GGVS 516
              A      GGLA    + A  T      +P+ GG A    +G  +          GG++
Sbjct: 1175 PAATPPSPKGGLATPSPKGAPTTPAATPPSPK-GGLATPSPKGAPTTPAATPPSPKGGLA 1233

Query: 517  PALAAKASGAPAA 529
                  A   PAA
Sbjct: 1234 TPSPKGAPTTPAA 1246



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 61/243 (25%), Positives = 87/243 (35%), Gaps = 32/243 (13%)

Query: 230  EEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPRE 289
            E PA P +   P     +     LL     A  AP       A++  S  P+   A P  
Sbjct: 1515 EVPATPSSRRDP-----IAPTATLLSKKTPATLAPKEALIPPAMTVPS--PKKTPAIPTP 1567

Query: 290  PQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEG 349
             + P +P     S  P++  +      SP     P     P  + A  P      + E+G
Sbjct: 1568 KEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKG 1627

Query: 350  EEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEA-----QGPDAP-AAASLPGSPAP 403
                   AP+G+P    +P V    P  L + P   A      G   P A+  LP    P
Sbjct: 1628 PA---TPAPKGTP---TSPPV---TPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGP 1678

Query: 404  S---QRCFKPYPLITPCYIKTTTRQLSSPNHSPSQSPNQSPRIKRRPEPSLSRGSRTALA 460
            +   +    P P  TP  I   TR+      S + SP         P+PS   GS+  L+
Sbjct: 1679 TALKEVLVAPAPESTP-IITAPTRKGPQTKKSSATSPPIC------PDPSAKNGSKGPLS 1731

Query: 461  SVA 463
            +VA
Sbjct: 1732 TVA 1734



 Score = 41.2 bits (95), Expect = 0.009
 Identities = 58/232 (25%), Positives = 70/232 (30%), Gaps = 27/232 (11%)

Query: 883  LPGMTVPTLPSTAIPQPPPLQGTEMLP------------PPPPPLPGAGIPPPPPLPGAG 930
            +PG    T+P+T    P P   T +LP             P P LP    P P   P + 
Sbjct: 1    MPGEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSA 60

Query: 931  ILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPP 990
                 P P        PL    +P P    G  +PL     G     P  LP    PP  
Sbjct: 61   ANQASPFPSPSTIASTPL---EVPFPQSSSGTALPL-----GTAPEAPTFLPNLIGPPIS 112

Query: 991  PLPGAGIPP--PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP----PPPLPGAGIPPP 1044
            P   A   P   P L G       PL    + P      +  PP     PP         
Sbjct: 113  PAALALASPMIAPTLKGTP-SSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGS 171

Query: 1045 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1096
                 A I P  P       P   +P     P PP   + +P     P A I
Sbjct: 172  VITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASI 223



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 74/293 (25%), Positives = 96/293 (32%), Gaps = 62/293 (21%)

Query: 230  EEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPRE 289
            + PA   T+ SP+        R    P G     P SP  + A +  +  P S    P  
Sbjct: 907  QAPALSMTSSSPKKA------RATPAPKG----IPASPSPKGAPTPPAATPPSPKGGPAT 956

Query: 290  PQQ----------PPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEA-AGAP 338
            P            PPSP G P + +P      PAA         P P+ GP   +  GAP
Sbjct: 957  PSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATP-------PSPKGGPATPSPKGAP 1009

Query: 339  VRGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEE------AQGPDAP 392
               A              +P+GSP     P+     P      P+         +G    
Sbjct: 1010 TPPA----------VTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTT 1059

Query: 393  AAASLP---GSPA-PSQRCFKPYPLITPCYIKTTTRQLSSPNHSP-SQSPNQSPRIKRRP 447
             AA+LP   G PA PS +     P  TP           SP   P + SP  +P      
Sbjct: 1060 PAATLPSPKGGPATPSLKGAPTPPAATP----------PSPKGGPATPSPKGAPMPPAAT 1109

Query: 448  EPSLSRGSRTAL---ASVAAPAKKHRADGGLAAGLSRSADWTEELGARTPRVG 497
             PS   G  T     A     A      GGLA    + A  T      +P+ G
Sbjct: 1110 PPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGG 1162



 Score = 37.0 bits (84), Expect = 0.17
 Identities = 89/373 (23%), Positives = 111/373 (29%), Gaps = 52/373 (13%)

Query: 901  PLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLP 960
            P + TE +P     LP          P A    LP      +      PG  +PP    P
Sbjct: 2    PGEATETVPATEQELPQ---------PQAETAVLPMSSALSVTAALGQPGPTLPP----P 48

Query: 961  GAGIPLPPPLPGAGIPPPPPLPG--AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1018
             +  P   PL  A    P P P   A  P   P P +      PL G     P  LP   
Sbjct: 49   CSPAPQQCPLSAANQASPFPSPSTIASTPLEVPFPQSSSGTALPL-GTAPEAPTFLPNLI 107

Query: 1019 IPPPPPLPGAGIPP--PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1076
             PP  P   A   P   P L G       PL    + P      +  PP        +  
Sbjct: 108  GPPISPAALALASPMIAPTLKGTP-SSSAPLALVALAPHSVQKSSAFPP-------NLLT 159

Query: 1077 PPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1136
             PP              A I P  P   +   P   +P     P PP   + +P     P
Sbjct: 160  SPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTP 219

Query: 1137 GAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPP----PPLPGVGIPPPPPLPG 1192
             A I       + G+        A +P   P     I  P      +  V I P  P   
Sbjct: 220  MASI-------QSGV--------ASLPQTTPTTTLAIASPQVKDTTISSVLISPQNP-GS 263

Query: 1193 VGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPP------GTGIPPPPLLPVSGPPLL 1246
            + +  P   P A       LP +      A P  PP      G+ + P          LL
Sbjct: 264  LSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLL 323

Query: 1247 PQVGSSTLPTPQV 1259
             Q G S L  P V
Sbjct: 324  GQTGPSALSDPTV 336



 Score = 31.2 bits (69), Expect = 9.1
 Identities = 51/192 (26%), Positives = 65/192 (33%), Gaps = 17/192 (8%)

Query: 856  PSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEM----LPPP 911
            P+ PP PC+ +    P        P P P  T+ + P   +P P    GT +     P  
Sbjct: 43   PTLPP-PCSPAPQQCPLSAANQASPFPSPS-TIASTP-LEVPFPQSSSGTALPLGTAPEA 99

Query: 912  PPPLPGAGIPP--PPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPP 969
            P  LP    PP  P  L  A  +  P L G    P    P A +   P         PP 
Sbjct: 100  PTFLPNLIGPPISPAALALASPMIAPTLKGT---PSSSAPLALVALAPHSVQKSSAFPPN 156

Query: 970  LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1029
            L    +  PP +  A       L  A I P  P       P   +P     P PP   + 
Sbjct: 157  L----LTSPPSVAVAESGSVITL-SAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVST 211

Query: 1030 IPPPPPLPGAGI 1041
            +P     P A I
Sbjct: 212  VPYHCVTPMASI 223


>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
            1 [Homo sapiens]
          Length = 1250

 Score =  191 bits (484), Expect = 7e-48
 Identities = 175/585 (29%), Positives = 205/585 (35%), Gaps = 175/585 (29%)

Query: 857  SPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLP 916
            SP P   T  ++S P   + PPPPPP P            P PPP       PPPPPPLP
Sbjct: 610  SPQPKIVTPYTASQPSPPLPPPPPPPPP------------PPPPP-------PPPPPPLP 650

Query: 917  GAGI--------------------------------PPPPPLPGAGILPLPPLPGAGIPP 944
                                                P PP +    + P   +P  G+ P
Sbjct: 651  SQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVP 710

Query: 945  PPPLPGAAIPPPPPLPGAGI------PLPPPLPGAGIPPP--------------PPLPGA 984
            PPP      PPPPP PG+ +      P  P LP    PPP              PP P  
Sbjct: 711  PPP-----PPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTP-- 763

Query: 985  GIPPPPPLPGAGIPPPPPLPGAGIPPP--------------PPLPGAGIPP---PPPLPG 1027
              PPPPP+P    P  PP P   IP P              PP P   +PP    P  P 
Sbjct: 764  --PPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPA 821

Query: 1028 AGIPPPPPLPGAGIPPPP-PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1086
            + IPP PP P   +PPP  P   +    PPP P + +P       +  PPPP  P     
Sbjct: 822  SYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQ 881

Query: 1087 PPPPLPGAGIPPPPPLPGV---GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1143
            P  P+P    P  PP         P   P+P    PPPPP      PPPPP P    PPP
Sbjct: 882  PLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSP-VPAPPP 940

Query: 1144 PPLPRVGIPP-----------PPPLPGAGIPPPPPLPGAGIP-------PPPPLPGV--- 1182
            PP P     P               PG   PPP P   + I        P P  P V   
Sbjct: 941  PPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSL 1000

Query: 1183 ----------GIPPPPPLPGVGIPPPP---PLPGAGIP----------PPPPLPGMGIPP 1219
                      G P    LP    PP P    L G  +P            P L G G   
Sbjct: 1001 VSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDS 1060

Query: 1220 APAPPLPPPGTGIPPPP---LLPVSGPPL-LPQVGSSTLPTPQVCGFLPPPLPSGLFGLG 1275
                P PP  +  PPPP    LP+  PP+ +P V S    +P+V    P P         
Sbjct: 1061 VVEFPSPPSDSDFPPPPPETELPL--PPIEIPAVFSGN-TSPKVAVVNPQP--------- 1108

Query: 1276 MNQDKGSRKQPIEPCRPMKPLYWTRIQLHSKRDSSTSLIWEKIEE 1320
                K S K+   P RP             KR+ ST L   +I E
Sbjct: 1109 QQWSKMSVKKAPPPTRP-------------KRNDSTRLTQAEISE 1140



 Score =  180 bits (456), Expect = 1e-44
 Identities = 137/401 (34%), Positives = 155/401 (38%), Gaps = 116/401 (28%)

Query: 953  IPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL-----PGAG 1007
            +PP  P P    P     P   +PPPPP P    PPPPP P    PPPPPL     P AG
Sbjct: 606  VPPLSPQPKIVTPYTASQPSPPLPPPPPPPP---PPPPPPP----PPPPPLPSQSAPSAG 658

Query: 1008 IPPPPPLPGAGI----------------PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1051
               P  +  + I                P PP +    + P   +P  G+ PPPP     
Sbjct: 659  SAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPP----- 713

Query: 1052 IPPPPPLPGAGI------PPPPPLPGAGIPPP--------------PPLPGAGIPPPPPL 1091
             PPPPP PG+ +      P  P LP    PPP              PP P    PPPPP+
Sbjct: 714  PPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTP----PPPPPI 769

Query: 1092 PGAGIPPPPPLPGVGIPPP--------------PPLPGAGIPP---PPPLPGAGIPPPPP 1134
            P    P  PP P V IP P              PP P   +PP    P  P + IPP PP
Sbjct: 770  PAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPP 829

Query: 1135 LPGAGIPPPPPLPR----VGIPPPPPLP---------GAGIPPPPPLPGAGIPPPPPLPG 1181
             P   + PPP LP+       PPP PL           +  PPPP  P     P  P+P 
Sbjct: 830  TPPVPV-PPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPA 888

Query: 1182 VGIPPPP--------------PLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPP 1227
               P  P              P+P    PPPPP      PPPPP       P PAPP PP
Sbjct: 889  NVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPP------SPVPAPPPPP 942

Query: 1228 PGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLP 1268
            P T  P P     SG P     G  T  T    G  PPP P
Sbjct: 943  PPTASPTP---DKSGSP-----GKKTSKTSSPGGKKPPPTP 975



 Score =  173 bits (438), Expect = 1e-42
 Identities = 162/529 (30%), Positives = 198/529 (37%), Gaps = 103/529 (19%)

Query: 789  VSPR-RISVQLDSHQPTQSIS-----------QPPPPPSLLWSAGQGQPGSQPP----HS 832
            +SP+ +I     + QP+  +             PPPPP  L S      GS  P    +S
Sbjct: 609  LSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYS 668

Query: 833  ISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGL-----GMVPPPPPPLPGMT 887
              T  Q + +HS  + FK       PP  P  +S S  P +     G+VPPPPPP P  T
Sbjct: 669  TITRLQNASQHS-GALFK-------PPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPT 720

Query: 888  -------------VPTLPSTAIPQPPPL---------QGTEMLPPPPPPLPGAGIPPPPP 925
                          P+LP  + P PPPL         Q     PPPPPP+P    P  PP
Sbjct: 721  PGSAMAQLKPAPCAPSLPQFSAP-PPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPP 779

Query: 926  LPGAGI--------------LPLPPLPGAGIPP---PPPLPGAAIPPPPPLPGAGIPLPP 968
             P   I                 PP P   +PP    P  P + IPP PP P   +P PP
Sbjct: 780  KPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVP-PP 838

Query: 969  PLPG----AGIPPPPPLP---------GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1015
             LP        PPP PL           +  PPPP  P     P  P+P    P  PP  
Sbjct: 839  TLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAV 898

Query: 1016 GA---GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA 1072
             A     P   P+P    PPPPP      PPPPP P    PPPPP   +  P     PG 
Sbjct: 899  KAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGK 958

Query: 1073 GIPPPPPLPGAGIPPPPPLPGAGIP-------PPPPLPGVG--IPPPPPLPGAGIPPPPP 1123
                    PG   PPP P   + I        P P  P V   +    P   +G P    
Sbjct: 959  KTSKTSS-PGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKET 1017

Query: 1124 LPGAGIPPPP-PLPGAGIPPPPPLPRVGIPPPPP-LPGAG----IPPPPPLPGAGIPPPP 1177
            LP    PP P  L  +G+  P  L +  +    P L G G    +  P P   +  PPPP
Sbjct: 1018 LPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPP 1077

Query: 1178 PLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLP 1226
            P   + + PP  +P V      P      P P     M +  AP P  P
Sbjct: 1078 PETELPL-PPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRP 1125



 Score =  125 bits (314), Expect = 4e-28
 Identities = 127/451 (28%), Positives = 163/451 (36%), Gaps = 62/451 (13%)

Query: 755  LTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQ---LDSHQPTQSISQ-- 809
            + +PP   +P  PP PP    G             S  + S     L  HQ  Q I+Q  
Sbjct: 701  ILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQ-VQHITQVA 759

Query: 810  ---PPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTES 866
               PPPPP +        P   PP  + T    +   +V+     +      PP+P  + 
Sbjct: 760  PPTPPPPPPI----PAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKK 815

Query: 867  SSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLP---------G 917
              + P   +  PP PP P + VP       P   P Q +    PPP PL           
Sbjct: 816  QPAFPASYI--PPSPPTPPVPVP-------PPTLPKQQSFCAKPPPSPLSPVPSVVKQIA 866

Query: 918  AGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPP 977
            +  PPPP  P     PL P+P    P  PP    A+   P    + IP+P P      PP
Sbjct: 867  SQFPPPPTPPAMESQPLKPVPANVAPQSPP----AVKAKPKWQPSSIPVPSP----DFPP 918

Query: 978  PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1037
            PPP      PPPPP P    PPPPP   +  P     PG         PG   PPP P  
Sbjct: 919  PPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSS-PGGKKPPPTPQR 977

Query: 1038 GAGIP-------PPPPLPGAG--IPPPPPLPGAGIPPPPPLPGAGIPPPP-PLPGAGIPP 1087
             + I        P P  P     +    P   +G P    LP    PP P  L  +G+  
Sbjct: 978  NSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNL 1037

Query: 1088 PPPL-PGAGIPPPPPLPGVG----IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1142
            P  L  G      P L G G    +  P P   +  PPPPP       P PP+    +  
Sbjct: 1038 PGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETEL---PLPPIEIPAVFS 1094

Query: 1143 PPPLPRVGIPPPPPLPGAGI----PPPPPLP 1169
                P+V +  P P   + +     PPP  P
Sbjct: 1095 GNTSPKVAVVNPQPQQWSKMSVKKAPPPTRP 1125



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 139/575 (24%), Positives = 164/575 (28%), Gaps = 281/575 (48%)

Query: 810  PPPPPSLLWSAGQGQPGSQPP----HSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTE 865
            PPPPP  L S      GS  P    +S  T  Q + +HS  + FK       PP  P  +
Sbjct: 642  PPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHS-GALFK-------PPTPPVMQ 693

Query: 866  SSSSMPGL-----GMVPPPPPPLPGMT-------------VPTLPSTAIPQPPPL----- 902
            S S  P +     G+VPPPPPP P  T              P+LP  + P PPPL     
Sbjct: 694  SQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAP-PPPLKIHQV 752

Query: 903  ----QGTEMLPPPPPPLPGAGIPPPPPLP-------------------GAGILPLPPLPG 939
                Q     PPPPPP+P    P  PP P                    A   P PP+P 
Sbjct: 753  QHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPP 812

Query: 940  AG---------IPPPPPLPGAAIPPP------------PPLPGAGIP---------LPPP 969
            A          IPP PP P   +PPP            PP P + +P          PPP
Sbjct: 813  AKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPP 872

Query: 970  --------------------------------------LPGAGIPPPPPLPGAGIPPPPP 991
                                                  +P    PPPPP      PPPPP
Sbjct: 873  PTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPP 932

Query: 992  LPGAGIPPPPP---------------------LPGAGIPPPPPLPGAGIP-------PPP 1023
             P    PPPPP                      PG   PPP P   + I        P P
Sbjct: 933  SPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEP 992

Query: 1024 PLPGAG-------------------IPPP--PPLPG----AGIPPP------------PP 1046
              P                      +PPP  PP PG    +G+  P            P 
Sbjct: 993  KRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPV 1052

Query: 1047 LPGAG---------------IPPPPP---LPGAGIPPPPPLPGAGIP------------- 1075
            L G G                PPPPP   LP   I  P    G   P             
Sbjct: 1053 LSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWS 1112

Query: 1076 -------PPPPLPGAG-------------------IPPPPPLPGAGIP------------ 1097
                   PPP  P                      +P  P  P + +             
Sbjct: 1113 KMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRT 1172

Query: 1098 --------------------PPPPLPGVGIPPPPP 1112
                                P   +  + +PPPPP
Sbjct: 1173 LQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPP 1207



 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 58/197 (29%), Positives = 68/197 (34%), Gaps = 60/197 (30%)

Query: 1140 IPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGI---- 1195
            +PP  P P++  P     P   +PPPPP P    PPPPP P    PPPPPLP        
Sbjct: 606  VPPLSPQPKIVTPYTASQPSPPLPPPPPPPP---PPPPPPP----PPPPPLPSQSAPSAG 658

Query: 1196 ----------------------------PPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPP 1227
                                        P PP +    + P   +P  G+ P P PP PP
Sbjct: 659  SAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPP 718

Query: 1228 PGTGIPPPPLLPVSGPPLLPQVGSSTLP--------TPQVCGFLPPPLPSGLFGLGMNQD 1279
            P  G     L P    P LPQ  +   P          QV    PPP P           
Sbjct: 719  PTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP----------- 767

Query: 1280 KGSRKQPIEPCRPMKPL 1296
                  P+ P  P KPL
Sbjct: 768  --PIPAPLPPQAPPKPL 782



 Score = 45.1 bits (105), Expect = 6e-04
 Identities = 75/320 (23%), Positives = 106/320 (33%), Gaps = 64/320 (20%)

Query: 748  PTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSI 807
            P E   V   PP   +P  PP PP   S    K  S             +  S   +   
Sbjct: 920  PPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGS-----------PGKKTSKTSSPGG 968

Query: 808  SQPPPPP----SLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLP- 862
             +PPP P    S+  S+G   P  + P   S   + +      S  K +   P+ PP P 
Sbjct: 969  KKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPG 1028

Query: 863  -CTESSSSMPGL---GMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGA 918
                S  ++PG+   G V    P L G                 +G + +   P P   +
Sbjct: 1029 KLNLSGVNLPGVLQQGCVSAKAPVLSG-----------------RGKDSVVEFPSPPSDS 1071

Query: 919  GIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPL---PPP------ 969
              PPPPP      LPLPP+    +      P  A+  P P   + + +   PPP      
Sbjct: 1072 DFPPPPP---ETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRN 1128

Query: 970  ----LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP--------PLPGAGIPPPPPLPG- 1016
                L  A I   P +    +P  P  P + +   P         L    I     L   
Sbjct: 1129 DSTRLTQAEISEQPTM-ATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSR 1187

Query: 1017 -AGIPPPPPLPGAGIPPPPP 1035
             +   P   +    +PPPPP
Sbjct: 1188 MSRAEPTATMDDMALPPPPP 1207



 Score = 40.0 bits (92), Expect = 0.020
 Identities = 68/270 (25%), Positives = 91/270 (33%), Gaps = 77/270 (28%)

Query: 745  QTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPT 804
            +TS T   G    PP            GAE  P+ K  S  SL+    + +   +S  P+
Sbjct: 959  KTSKTSSPGGKKPPPTPQRNSSIKSSSGAEH-PEPKRPSVDSLV---SKFTPPAESGSPS 1014

Query: 805  QSISQPP---PPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPL 861
            +    PP   P P  L  +G   PG      +S +          S  +     PSPP  
Sbjct: 1015 KETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVE----FPSPP-- 1068

Query: 862  PCTESSSSMPGLGMVPPPPP---PLPGMTVP------TLPSTAIPQPPPLQGTEM----L 908
                S S  P     PPPP    PLP + +P      T P  A+  P P Q ++M     
Sbjct: 1069 ----SDSDFP-----PPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKA 1119

Query: 909  PPPPPP-------LPGAGIPPPPPLPGAGILPLPPL---------PG------------- 939
            PPP  P       L  A I   P +  A ++P  P          PG             
Sbjct: 1120 PPPTRPKRNDSTRLTQAEISEQPTM--ATVVPQVPTSPKSSLSVQPGFLADLNRTLQRKS 1177

Query: 940  -----------AGIPPPPPLPGAAIPPPPP 958
                       +   P   +   A+PPPPP
Sbjct: 1178 ITRHGSLSSRMSRAEPTATMDDMALPPPPP 1207



 Score = 36.6 bits (83), Expect = 0.22
 Identities = 47/190 (24%), Positives = 69/190 (36%), Gaps = 34/190 (17%)

Query: 235  PPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSA--LSDLPESLAAEPREPQQ 292
            PP+ +SP P     +          A + P  P T  A+ +  L  +P ++A     PQ 
Sbjct: 851  PPSPLSPVPSVVKQI----------ASQFP-PPPTPPAMESQPLKPVPANVA-----PQS 894

Query: 293  PPSPGGLPVSEAPSLPAAQPAAKDSP--SSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGE 350
            PP+    P  +  S+P   P     P  SS  FP P   P       P   A  T ++  
Sbjct: 895  PPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSG 954

Query: 351  EDAFEDAPRGSPGEEWAPEVGEDAPQRL--------GEEPEEEAQGPDAPAAASLP--GS 400
                + +   SPG +  P      PQR          E PE +    D+  +   P   S
Sbjct: 955  SPGKKTSKTSSPGGKKPP----PTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAES 1010

Query: 401  PAPSQRCFKP 410
             +PS+    P
Sbjct: 1011 GSPSKETLPP 1020



 Score = 31.2 bits (69), Expect = 9.1
 Identities = 25/89 (28%), Positives = 32/89 (35%), Gaps = 10/89 (11%)

Query: 232  PAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQ 291
            P  PP   SP P       +     S   G+ P  P T Q  S++     +   EP+ P 
Sbjct: 939  PPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKP--PPTPQRNSSIKSSSGAEHPEPKRPS 996

Query: 292  --------QPPSPGGLPVSEAPSLPAAQP 312
                     PP+  G P  E    PAA P
Sbjct: 997  VDSLVSKFTPPAESGSPSKETLPPPAAPP 1025


>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
          Length = 1240

 Score =  191 bits (484), Expect = 7e-48
 Identities = 173/586 (29%), Positives = 264/586 (45%), Gaps = 70/586 (11%)

Query: 1138 AGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGI------PPPPPLP 1191
            A  PPPPP       PPP LPG+   PPPP      PPPPPLP VG       PPPPPLP
Sbjct: 418  ASTPPPPP-------PPPLLPGSSAEPPPP------PPPPPLPSVGAKALPTAPPPPPLP 464

Query: 1192 GVGI------PPPPPLPGAGI---PPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSG 1242
            G+G       P PPPLPG+     PPPPPLPG+G PP P P LP  G G PPPP      
Sbjct: 465  GLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPP------ 518

Query: 1243 PPLLPQVGSSTLPTPQVCGFLPPPLPSGL-FGLGMNQDKGSRKQPIEPCRPMKPLYWTRI 1301
            PPLLP   S     P V G +   + + +  GLG +    S ++   P   MK L W ++
Sbjct: 519  PPLLPCTCS-----PPVAGGMEEVIVAQVDHGLG-SAWVPSHRRVNPPTLRMKKLNWQKL 572

Query: 1302 QLHSKRDSSTSLIWEKIEEPSIDCHE-----FEELFSKTAVKERKKPISDTISKTKAKQV 1356
              +  R+ ++  +W  +  P  +  E      E LFS  A K  K+P        K  + 
Sbjct: 573  PSNVAREHNS--MWASLSSPDAEAVEPDFSSIERLFSFPAAKP-KEPTMVAPRARKEPKE 629

Query: 1357 VKLLSNKRSQAVGILMSSLHLDMKDIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIE 1416
            +  L  K+S  + I +       +++   +   D +  D+E L+ L +   +  E+E + 
Sbjct: 630  ITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLR 689

Query: 1417 KHGRSSKDKENAKSLDKPEQFLYELSLIPNFSERVFCILFQSTFSESICSIRRKLELLQK 1476
                 +  +E AK L   + F   L  IP +  R+ C+L     +  +  +R K +L+  
Sbjct: 690  -----AFTEERAK-LASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLA 743

Query: 1477 LCETLKNGPGVMQVLGLVLAFGNYMNGGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLS 1536
             CE+L     +     L+L  GN++N G+ T G ADGF +  L KL + KS  N  +LL 
Sbjct: 744  ACESLLTSRQLPIFCQLILRIGNFLNYGSHT-GDADGFKISTLLKLTETKSQQNRVTLLH 802

Query: 1537 YIVSYYLRNFDEDAGKEQCLFPLPEPQDLFQASQMKFEDFQKDLRKLKKDLKACEVEAGK 1596
            +++        E+A K      L  P+DL Q SQ    + +    +   +LK   +E  +
Sbjct: 803  HVL--------EEAEKSHPDL-LQLPRDLEQPSQAAGINLEIIRSEASSNLKKL-LETER 852

Query: 1597 VYQVSSKEHMQPFKENMEQFIIQAKIDQEAEENSLTETHKCFLETTAYFFMKPKLGEKEV 1656
                S  E  + + E ++  I   +   E  E ++ +  +   +       +  L +   
Sbjct: 853  KVSASVAEVQEQYTERLQASISAFRALDELFE-AIEQKQRELADYLCEDAQQLSLEDTFS 911

Query: 1657 SPNAFFSIWHEFSSDFKDFWKKENKLLLQERVKE-AEEVCRQKKGK 1701
            +  AF  ++     + KD  +KE     + R ++ AEE  R+ +G+
Sbjct: 912  TMKAFRDLFLRALKENKD--RKEQAAKAERRKQQLAEEEARRPRGE 955



 Score =  126 bits (317), Expect = 2e-28
 Identities = 74/144 (51%), Positives = 77/144 (53%), Gaps = 39/144 (27%)

Query: 1006 AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1065
            A  PPPPP       PPP LPG+   PPPP      PPPPPLP  G    P  P     P
Sbjct: 418  ASTPPPPP-------PPPLLPGSSAEPPPP------PPPPPLPSVGAKALPTAP-----P 459

Query: 1066 PPPLPGAGI--PPPPPLPGAGIPPPPPLPGAG---IPPPPPLPGVGIPPPPP--LPGAGI 1118
            PPPLPG G   PP PPL       PPPLPG+     PPPPPLPG+G PPPPP  LPG G 
Sbjct: 460  PPPLPGLGAMAPPAPPL-------PPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGW 512

Query: 1119 PPPPPLPGAGIPPPPPLPGAGIPP 1142
             PPP       PPPP LP    PP
Sbjct: 513  GPPP-------PPPPLLPCTCSPP 529



 Score =  125 bits (313), Expect = 5e-28
 Identities = 73/141 (51%), Positives = 74/141 (52%), Gaps = 33/141 (23%)

Query: 1061 AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPP 1120
            A  PPPPP       PPP LPG+   PPPP      PPPPPLP VG    P  P     P
Sbjct: 418  ASTPPPPP-------PPPLLPGSSAEPPPP------PPPPPLPSVGAKALPTAP-----P 459

Query: 1121 PPPLPGAGI--PPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPP--LPGAGIPPP 1176
            PPPLPG G   PP PPLP    PP P       PPPPPLPG G PPPPP  LPG G  PP
Sbjct: 460  PPPLPGLGAMAPPAPPLP----PPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPP 515

Query: 1177 PPLPGVGIPPPPPLPGVGIPP 1197
            P       PPPP LP    PP
Sbjct: 516  P-------PPPPLLPCTCSPP 529



 Score =  123 bits (309), Expect = 1e-27
 Identities = 75/153 (49%), Positives = 78/153 (50%), Gaps = 38/153 (24%)

Query: 942  IPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1001
            +  P  L   A  PPPP P      PP LPG+   PPPP      PPPPPLP  G    P
Sbjct: 408  VSQPRALEQQASTPPPPPP------PPLLPGSSAEPPPP------PPPPPLPSVGAKALP 455

Query: 1002 PLPGAGIPPPPPLPGAGI--PPPPPLPGAGIPPPPPLPGAG---IPPPPPLPGAGIPPPP 1056
              P     PPPPLPG G   PP PPL       PPPLPG+     PPPPPLPG G PPPP
Sbjct: 456  TAP-----PPPPLPGLGAMAPPAPPL-------PPPLPGSCEFLPPPPPPLPGLGCPPPP 503

Query: 1057 P--LPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1087
            P  LPG G  PPP       PPPP LP    PP
Sbjct: 504  PPLLPGMGWGPPP-------PPPPLLPCTCSPP 529



 Score =  123 bits (308), Expect = 2e-27
 Identities = 72/140 (51%), Positives = 76/140 (54%), Gaps = 33/140 (23%)

Query: 984  AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1043
            A  PPPPP       PPP LPG+   PPPP      PPPPPLP  G    P  P     P
Sbjct: 418  ASTPPPPP-------PPPLLPGSSAEPPPP------PPPPPLPSVGAKALPTAP-----P 459

Query: 1044 PPPLPGAGI--PPPPPLPGAGIPPPPPLPGAGI---PPPPPLPGAGIPPPPP--LPGAGI 1096
            PPPLPG G   PP PPLP       PPLPG+     PPPPPLPG G PPPPP  LPG G 
Sbjct: 460  PPPLPGLGAMAPPAPPLP-------PPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGW 512

Query: 1097 -PPPPPLPGVGIPPPPPLPG 1115
             PPPPP P +     PP+ G
Sbjct: 513  GPPPPPPPLLPCTCSPPVAG 532



 Score =  120 bits (301), Expect = 1e-26
 Identities = 72/148 (48%), Positives = 77/148 (52%), Gaps = 37/148 (25%)

Query: 896  IPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAI-- 953
            + QP  L+     PPPPPP        PP LPG+   P PP      PPPPPLP      
Sbjct: 408  VSQPRALEQQASTPPPPPP--------PPLLPGSSAEPPPP------PPPPPLPSVGAKA 453

Query: 954  ----PPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAG---IPPPPPLPGAGIPPPPP--LP 1004
                PPPPPLPG G  + PP P    P PPPLPG+     PPPPPLPG G PPPPP  LP
Sbjct: 454  LPTAPPPPPLPGLG-AMAPPAP----PLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLP 508

Query: 1005 GAGIPPPPPLPGAGIPPPPPLPGAGIPP 1032
            G G  PPP       PPPP LP    PP
Sbjct: 509  GMGWGPPP-------PPPPLLPCTCSPP 529



 Score =  119 bits (297), Expect = 3e-26
 Identities = 74/157 (47%), Positives = 79/157 (50%), Gaps = 46/157 (29%)

Query: 1041 IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG----- 1095
            +  P  L      PPPP P      PP LPG+   PPPP      PPPPPLP  G     
Sbjct: 408  VSQPRALEQQASTPPPPPP------PPLLPGSSAEPPPP------PPPPPLPSVGAKALP 455

Query: 1096 -IPPPPPLPGVG--IPPPPPLPGAGIPPPPPLPGA--GIPP-PPPLPGAGIPPPPPLPRV 1149
              PPPPPLPG+G   PP PPL       PPPLPG+   +PP PPPLPG G PPP      
Sbjct: 456  TAPPPPPLPGLGAMAPPAPPL-------PPPLPGSCEFLPPPPPPLPGLGCPPP------ 502

Query: 1150 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPP 1186
               PPP LPG G  PPP       PPPP LP    PP
Sbjct: 503  ---PPPLLPGMGWGPPP-------PPPPLLPCTCSPP 529



 Score =  112 bits (279), Expect = 4e-24
 Identities = 75/204 (36%), Positives = 94/204 (46%), Gaps = 36/204 (17%)

Query: 809 QPPPPP------SLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLP 862
           +P P P      S+  +  Q Q GS P ++ + +     +   ++A     +      + 
Sbjct: 347 RPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESIL 406

Query: 863 CTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGI-- 920
                 ++      PPPPPP      P LP ++   PPP        PPPPPLP  G   
Sbjct: 407 KVSQPRALEQQASTPPPPPP-----PPLLPGSSAEPPPP--------PPPPPLPSVGAKA 453

Query: 921 ----PPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAI---PPPPPLPGAGIPLPPP--LP 971
               PPPPPLPG G +  PP P    P PPPLPG+     PPPPPLPG G P PPP  LP
Sbjct: 454 LPTAPPPPPLPGLGAMA-PPAP----PLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLP 508

Query: 972 GAGI-PPPPPLPGAGIPPPPPLPG 994
           G G  PPPPP P       PP+ G
Sbjct: 509 GMGWGPPPPPPPLLPCTCSPPVAG 532



 Score =  101 bits (251), Expect = 7e-21
 Identities = 78/241 (32%), Positives = 98/241 (40%), Gaps = 63/241 (26%)

Query: 733 VRHHRILEAKSIQTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPR 792
           V+ H+ ++A ++  S        T  P   + G+ P    A        C  +    S  
Sbjct: 354 VKAHKSVQA-NLDQSQRGSSPQNTTTPKPSVEGQQPAAAAA--------CEPVDHAQSES 404

Query: 793 RISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNS 852
            + V        Q+ + PPPPP  L      +P   PP                      
Sbjct: 405 ILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPP---------------------- 442

Query: 853 CNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGT-EMLPPP 911
                PPPLP +  + ++P      PPPPPLPG+     P  A P PPPL G+ E LPPP
Sbjct: 443 -----PPPLP-SVGAKALP----TAPPPPPLPGLGAMAPP--APPLPPPLPGSCEFLPPP 490

Query: 912 PPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLP 971
           PPPLPG G PPPPP         P LPG G  PPP       PPPP LP       PP+ 
Sbjct: 491 PPPLPGLGCPPPPP---------PLLPGMGWGPPP-------PPPPLLP---CTCSPPVA 531

Query: 972 G 972
           G
Sbjct: 532 G 532



 Score = 33.9 bits (76), Expect = 1.4
 Identities = 34/147 (23%), Positives = 53/147 (36%), Gaps = 9/147 (6%)

Query: 192 QEDLLSDIQQAIRLQQQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVSPQPGAFLGLDR 251
           QE  L ++ + +   + + +   L    +  Q  L  ++  ++P    +P+P        
Sbjct: 330 QECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPS------- 382

Query: 252 FLLGPSGGAGEAPGSPDTEQALSALS-DLPESLAAEPREPQQPPSPGGLPVSEAPSLPAA 310
            + G    A  A    D  Q+ S L    P +L  +   P  PP P  LP S A   P  
Sbjct: 383 -VEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPP 441

Query: 311 QPAAKDSPSSTAFPFPEAGPGEEAAGA 337
            P    S  + A P     P     GA
Sbjct: 442 PPPPLPSVGAKALPTAPPPPPLPGLGA 468


>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
          Length = 1249

 Score =  191 bits (484), Expect = 7e-48
 Identities = 173/586 (29%), Positives = 264/586 (45%), Gaps = 70/586 (11%)

Query: 1138 AGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGI------PPPPPLP 1191
            A  PPPPP       PPP LPG+   PPPP      PPPPPLP VG       PPPPPLP
Sbjct: 418  ASTPPPPP-------PPPLLPGSSAEPPPP------PPPPPLPSVGAKALPTAPPPPPLP 464

Query: 1192 GVGI------PPPPPLPGAGI---PPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSG 1242
            G+G       P PPPLPG+     PPPPPLPG+G PP P P LP  G G PPPP      
Sbjct: 465  GLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPP------ 518

Query: 1243 PPLLPQVGSSTLPTPQVCGFLPPPLPSGL-FGLGMNQDKGSRKQPIEPCRPMKPLYWTRI 1301
            PPLLP   S     P V G +   + + +  GLG +    S ++   P   MK L W ++
Sbjct: 519  PPLLPCTCS-----PPVAGGMEEVIVAQVDHGLG-SAWVPSHRRVNPPTLRMKKLNWQKL 572

Query: 1302 QLHSKRDSSTSLIWEKIEEPSIDCHE-----FEELFSKTAVKERKKPISDTISKTKAKQV 1356
              +  R+ ++  +W  +  P  +  E      E LFS  A K  K+P        K  + 
Sbjct: 573  PSNVAREHNS--MWASLSSPDAEAVEPDFSSIERLFSFPAAKP-KEPTMVAPRARKEPKE 629

Query: 1357 VKLLSNKRSQAVGILMSSLHLDMKDIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIE 1416
            +  L  K+S  + I +       +++   +   D +  D+E L+ L +   +  E+E + 
Sbjct: 630  ITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLR 689

Query: 1417 KHGRSSKDKENAKSLDKPEQFLYELSLIPNFSERVFCILFQSTFSESICSIRRKLELLQK 1476
                 +  +E AK L   + F   L  IP +  R+ C+L     +  +  +R K +L+  
Sbjct: 690  -----AFTEERAK-LASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLA 743

Query: 1477 LCETLKNGPGVMQVLGLVLAFGNYMNGGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLS 1536
             CE+L     +     L+L  GN++N G+ T G ADGF +  L KL + KS  N  +LL 
Sbjct: 744  ACESLLTSRQLPIFCQLILRIGNFLNYGSHT-GDADGFKISTLLKLTETKSQQNRVTLLH 802

Query: 1537 YIVSYYLRNFDEDAGKEQCLFPLPEPQDLFQASQMKFEDFQKDLRKLKKDLKACEVEAGK 1596
            +++        E+A K      L  P+DL Q SQ    + +    +   +LK   +E  +
Sbjct: 803  HVL--------EEAEKSHPDL-LQLPRDLEQPSQAAGINLEIIRSEASSNLKKL-LETER 852

Query: 1597 VYQVSSKEHMQPFKENMEQFIIQAKIDQEAEENSLTETHKCFLETTAYFFMKPKLGEKEV 1656
                S  E  + + E ++  I   +   E  E ++ +  +   +       +  L +   
Sbjct: 853  KVSASVAEVQEQYTERLQASISAFRALDELFE-AIEQKQRELADYLCEDAQQLSLEDTFS 911

Query: 1657 SPNAFFSIWHEFSSDFKDFWKKENKLLLQERVKE-AEEVCRQKKGK 1701
            +  AF  ++     + KD  +KE     + R ++ AEE  R+ +G+
Sbjct: 912  TMKAFRDLFLRALKENKD--RKEQAAKAERRKQQLAEEEARRPRGE 955



 Score =  126 bits (317), Expect = 2e-28
 Identities = 74/144 (51%), Positives = 77/144 (53%), Gaps = 39/144 (27%)

Query: 1006 AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1065
            A  PPPPP       PPP LPG+   PPPP      PPPPPLP  G    P  P     P
Sbjct: 418  ASTPPPPP-------PPPLLPGSSAEPPPP------PPPPPLPSVGAKALPTAP-----P 459

Query: 1066 PPPLPGAGI--PPPPPLPGAGIPPPPPLPGAG---IPPPPPLPGVGIPPPPP--LPGAGI 1118
            PPPLPG G   PP PPL       PPPLPG+     PPPPPLPG+G PPPPP  LPG G 
Sbjct: 460  PPPLPGLGAMAPPAPPL-------PPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGW 512

Query: 1119 PPPPPLPGAGIPPPPPLPGAGIPP 1142
             PPP       PPPP LP    PP
Sbjct: 513  GPPP-------PPPPLLPCTCSPP 529



 Score =  125 bits (313), Expect = 5e-28
 Identities = 73/141 (51%), Positives = 74/141 (52%), Gaps = 33/141 (23%)

Query: 1061 AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPP 1120
            A  PPPPP       PPP LPG+   PPPP      PPPPPLP VG    P  P     P
Sbjct: 418  ASTPPPPP-------PPPLLPGSSAEPPPP------PPPPPLPSVGAKALPTAP-----P 459

Query: 1121 PPPLPGAGI--PPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPP--LPGAGIPPP 1176
            PPPLPG G   PP PPLP    PP P       PPPPPLPG G PPPPP  LPG G  PP
Sbjct: 460  PPPLPGLGAMAPPAPPLP----PPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPP 515

Query: 1177 PPLPGVGIPPPPPLPGVGIPP 1197
            P       PPPP LP    PP
Sbjct: 516  P-------PPPPLLPCTCSPP 529



 Score =  123 bits (309), Expect = 1e-27
 Identities = 75/153 (49%), Positives = 78/153 (50%), Gaps = 38/153 (24%)

Query: 942  IPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1001
            +  P  L   A  PPPP P      PP LPG+   PPPP      PPPPPLP  G    P
Sbjct: 408  VSQPRALEQQASTPPPPPP------PPLLPGSSAEPPPP------PPPPPLPSVGAKALP 455

Query: 1002 PLPGAGIPPPPPLPGAGI--PPPPPLPGAGIPPPPPLPGAG---IPPPPPLPGAGIPPPP 1056
              P     PPPPLPG G   PP PPL       PPPLPG+     PPPPPLPG G PPPP
Sbjct: 456  TAP-----PPPPLPGLGAMAPPAPPL-------PPPLPGSCEFLPPPPPPLPGLGCPPPP 503

Query: 1057 P--LPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1087
            P  LPG G  PPP       PPPP LP    PP
Sbjct: 504  PPLLPGMGWGPPP-------PPPPLLPCTCSPP 529



 Score =  123 bits (308), Expect = 2e-27
 Identities = 72/140 (51%), Positives = 76/140 (54%), Gaps = 33/140 (23%)

Query: 984  AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1043
            A  PPPPP       PPP LPG+   PPPP      PPPPPLP  G    P  P     P
Sbjct: 418  ASTPPPPP-------PPPLLPGSSAEPPPP------PPPPPLPSVGAKALPTAP-----P 459

Query: 1044 PPPLPGAGI--PPPPPLPGAGIPPPPPLPGAGI---PPPPPLPGAGIPPPPP--LPGAGI 1096
            PPPLPG G   PP PPLP       PPLPG+     PPPPPLPG G PPPPP  LPG G 
Sbjct: 460  PPPLPGLGAMAPPAPPLP-------PPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGW 512

Query: 1097 -PPPPPLPGVGIPPPPPLPG 1115
             PPPPP P +     PP+ G
Sbjct: 513  GPPPPPPPLLPCTCSPPVAG 532



 Score =  120 bits (301), Expect = 1e-26
 Identities = 72/148 (48%), Positives = 77/148 (52%), Gaps = 37/148 (25%)

Query: 896  IPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAI-- 953
            + QP  L+     PPPPPP        PP LPG+   P PP      PPPPPLP      
Sbjct: 408  VSQPRALEQQASTPPPPPP--------PPLLPGSSAEPPPP------PPPPPLPSVGAKA 453

Query: 954  ----PPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAG---IPPPPPLPGAGIPPPPP--LP 1004
                PPPPPLPG G  + PP P    P PPPLPG+     PPPPPLPG G PPPPP  LP
Sbjct: 454  LPTAPPPPPLPGLG-AMAPPAP----PLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLP 508

Query: 1005 GAGIPPPPPLPGAGIPPPPPLPGAGIPP 1032
            G G  PPP       PPPP LP    PP
Sbjct: 509  GMGWGPPP-------PPPPLLPCTCSPP 529



 Score =  119 bits (297), Expect = 3e-26
 Identities = 74/157 (47%), Positives = 79/157 (50%), Gaps = 46/157 (29%)

Query: 1041 IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG----- 1095
            +  P  L      PPPP P      PP LPG+   PPPP      PPPPPLP  G     
Sbjct: 408  VSQPRALEQQASTPPPPPP------PPLLPGSSAEPPPP------PPPPPLPSVGAKALP 455

Query: 1096 -IPPPPPLPGVG--IPPPPPLPGAGIPPPPPLPGA--GIPP-PPPLPGAGIPPPPPLPRV 1149
              PPPPPLPG+G   PP PPL       PPPLPG+   +PP PPPLPG G PPP      
Sbjct: 456  TAPPPPPLPGLGAMAPPAPPL-------PPPLPGSCEFLPPPPPPLPGLGCPPP------ 502

Query: 1150 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPP 1186
               PPP LPG G  PPP       PPPP LP    PP
Sbjct: 503  ---PPPLLPGMGWGPPP-------PPPPLLPCTCSPP 529



 Score =  112 bits (279), Expect = 4e-24
 Identities = 75/204 (36%), Positives = 94/204 (46%), Gaps = 36/204 (17%)

Query: 809 QPPPPP------SLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLP 862
           +P P P      S+  +  Q Q GS P ++ + +     +   ++A     +      + 
Sbjct: 347 RPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESIL 406

Query: 863 CTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGI-- 920
                 ++      PPPPPP      P LP ++   PPP        PPPPPLP  G   
Sbjct: 407 KVSQPRALEQQASTPPPPPP-----PPLLPGSSAEPPPP--------PPPPPLPSVGAKA 453

Query: 921 ----PPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAI---PPPPPLPGAGIPLPPP--LP 971
               PPPPPLPG G +  PP P    P PPPLPG+     PPPPPLPG G P PPP  LP
Sbjct: 454 LPTAPPPPPLPGLGAMA-PPAP----PLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLP 508

Query: 972 GAGI-PPPPPLPGAGIPPPPPLPG 994
           G G  PPPPP P       PP+ G
Sbjct: 509 GMGWGPPPPPPPLLPCTCSPPVAG 532



 Score =  101 bits (251), Expect = 7e-21
 Identities = 78/241 (32%), Positives = 98/241 (40%), Gaps = 63/241 (26%)

Query: 733 VRHHRILEAKSIQTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPR 792
           V+ H+ ++A ++  S        T  P   + G+ P    A        C  +    S  
Sbjct: 354 VKAHKSVQA-NLDQSQRGSSPQNTTTPKPSVEGQQPAAAAA--------CEPVDHAQSES 404

Query: 793 RISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNS 852
            + V        Q+ + PPPPP  L      +P   PP                      
Sbjct: 405 ILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPP---------------------- 442

Query: 853 CNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGT-EMLPPP 911
                PPPLP +  + ++P      PPPPPLPG+     P  A P PPPL G+ E LPPP
Sbjct: 443 -----PPPLP-SVGAKALP----TAPPPPPLPGLGAMAPP--APPLPPPLPGSCEFLPPP 490

Query: 912 PPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLP 971
           PPPLPG G PPPPP         P LPG G  PPP       PPPP LP       PP+ 
Sbjct: 491 PPPLPGLGCPPPPP---------PLLPGMGWGPPP-------PPPPLLP---CTCSPPVA 531

Query: 972 G 972
           G
Sbjct: 532 G 532



 Score = 33.9 bits (76), Expect = 1.4
 Identities = 34/147 (23%), Positives = 53/147 (36%), Gaps = 9/147 (6%)

Query: 192 QEDLLSDIQQAIRLQQQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVSPQPGAFLGLDR 251
           QE  L ++ + +   + + +   L    +  Q  L  ++  ++P    +P+P        
Sbjct: 330 QECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPS------- 382

Query: 252 FLLGPSGGAGEAPGSPDTEQALSALS-DLPESLAAEPREPQQPPSPGGLPVSEAPSLPAA 310
            + G    A  A    D  Q+ S L    P +L  +   P  PP P  LP S A   P  
Sbjct: 383 -VEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPP 441

Query: 311 QPAAKDSPSSTAFPFPEAGPGEEAAGA 337
            P    S  + A P     P     GA
Sbjct: 442 PPPPLPSVGAKALPTAPPPPPLPGLGA 468


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score =  182 bits (463), Expect = 2e-45
 Identities = 185/584 (31%), Positives = 226/584 (38%), Gaps = 96/584 (16%)

Query: 755  LTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPT-QSISQPPPP 813
            L  P   G   RP  PP   + P          + +P  ++    S  P+ Q++  PP  
Sbjct: 304  LATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPAT 363

Query: 814  PSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSM--P 871
            P          P  Q P S+ T       HS++S    +   PSP  L   ++++S+  P
Sbjct: 364  PPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAP--PSPLALSSLQATTSLGSP 421

Query: 872  GLG-----MVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPP---PLPGAGIPPP 923
             L      +   P      +T P+ P++  P  PPLQ    LP  PP    L  A  P  
Sbjct: 422  TLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLS 481

Query: 924  PPLPGAGILPLPPLPG-AGIPPPPPLPGAAIPP--------PPPL--PGAGIPLPPPLPG 972
             PL    I PL  L   A   P  PL    +PP        PP L  P A +  PP L  
Sbjct: 482  SPLT---IHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPP-LEN 537

Query: 973  AGIPPPPPLPGAGIP--------PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1024
                 PPPL  A  P        PP P P     PP PL      PPP  P +   PPP 
Sbjct: 538  LPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLT----TPPPETPSSIATPPPQ 593

Query: 1025 LPGAGIPPP------PPLPGAGIPPPPPLPGAGIPP--PPPLPGAGIP------PPPPLP 1070
             P A   PP      PPL     PPP   P   +PP   PP P A  P      P P  P
Sbjct: 594  APPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAP 653

Query: 1071 GA----------GIPPPPPLPGAGIPPP-PPLPGAGIPPPPPLPGVGIPP--PPPLPGAG 1117
             A            PP PP+     PP  PP+  +  PP    P +  PP   PP P A 
Sbjct: 654  NALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPAS 713

Query: 1118 IPPPPPLPGAGIPP--PPPL--PGAGIPPPPPLPRVGIPPPPPLPGAGIPPP--PPL--- 1168
               PP  P A  PP  PPPL  P   +PP P       P  PP+  +  PPP  PPL   
Sbjct: 714  ---PPMSPSATPPPQAPPPLAAPPLQVPPSP-------PASPPMSPSATPPPRVPPLLAA 763

Query: 1169 PGAGIPPPP----PLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPP 1224
            P   +PP P    P+  +  PPP   P +  PP   LP     PP   PG   P +P+  
Sbjct: 764  PPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPS----PPASFPGQA-PFSPSAS 818

Query: 1225 LPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLP 1268
            LP      PPP   PV   PLL QV  S   +P +     PP P
Sbjct: 819  LPMSPLATPPPQAPPVLAAPLL-QVPPSPPASPTLQAPRRPPTP 861



 Score =  182 bits (463), Expect = 2e-45
 Identities = 182/585 (31%), Positives = 219/585 (37%), Gaps = 102/585 (17%)

Query: 758  PPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPP--- 814
            P +  LP  P  PP     P +     +    S + I      H  T    Q PP P   
Sbjct: 352  PSLQTLPSPPATPPS--QAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLAL 409

Query: 815  -SLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGL 873
             SL  +   G P  Q  HS  T      + S++S  + +   P  PPL    S  + P L
Sbjct: 410  SSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPL 469

Query: 874  GM-----VPPPPPPLPGMTVPTLPSTAIPQP---------PPLQGTEMLPPPPPPLPGAG 919
                   V P   PL    +  L S A   P         PPL+    L PP    P A 
Sbjct: 470  QTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPAS 529

Query: 920  IPPPPPLPGAGILPLPPLPGAGIP--------PPPPLPGAAIPPPPPLPGAGIPLPPPLP 971
            +  PP L     L  PPL  A  P        PP P P     PP PL       PP  P
Sbjct: 530  LTTPP-LENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTP----PPETP 584

Query: 972  GAGIPPPPPLPGAGIPPP------PPLPGAGIPPPPPLPGAGIPP--PPPLPGAGIP--- 1020
             +   PPP  P A   PP      PPL     PPP   P   +PP   PP P A  P   
Sbjct: 585  SSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSP 644

Query: 1021 ---PPPPLPGA----------GIPPPPPLPGAGIPP-PPPLPGAGIPPPPPLPGAGIPP- 1065
               P P  P A            PP PP+     PP  PP+  +  PP    P    PP 
Sbjct: 645  LATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPL 704

Query: 1066 -PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP--PPPLPGVGIPPPPPLPGAGIPPP- 1121
              PP P    P  PP+  +  PPP   P    PP   PP P    P  PP+  +  PPP 
Sbjct: 705  QVPPSP----PASPPMSPSATPPPQAPPPLAAPPLQVPPSP----PASPPMSPSATPPPR 756

Query: 1122 -PPL---PGAGIPPPPP--LPGAGIPPPPPLPRVGIPPPP----PLPGAGIPPPPPL-PG 1170
             PPL   P   +PP PP  LP + +  PPP     +  PP    P P A  P   P  P 
Sbjct: 757  VPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPS 816

Query: 1171 AGIP------PPPPLPGV------GIPPPPPL-PGVGIPPPPPLPGAGIPPPPPLPGMGI 1217
            A +P      PPP  P V       +PP PP  P +  P  PP PG    P   + G  +
Sbjct: 817  ASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPG----PDTSVSGPRL 872

Query: 1218 PPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGF 1262
              A AP  PPP +  P   L   SGP L     S+T    ++ G+
Sbjct: 873  TLALAPGPPPPPSRSPSSTL---SGPDLAGHSSSATSTPEELRGY 914



 Score =  171 bits (433), Expect = 6e-42
 Identities = 206/670 (30%), Positives = 242/670 (36%), Gaps = 159/670 (23%)

Query: 743  SIQT-SPTEEGGVLTLPPVDGLPGRPPCPPGAES-------GPQTKFCSEISLIVSPRRI 794
            S+QT  P +    LT P +      PP P    S       G  T   +   L +SPR+ 
Sbjct: 382  SLQTIPPIQVPHSLTSPSLQA----PPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQT 437

Query: 795  SVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHS--------ISTEFQTSHEHSVS 846
               L S  P++  S PP  P L   A    P S P  +        +S+        ++S
Sbjct: 438  QASLTS--PSRPASTPPDSPPL--QAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALS 493

Query: 847  SAFKNSCNIPSP----PPLPCTESSSSMPGLGMVP-----PP--------PPPLPG---- 885
            S   +S   P      PPL  T+SS + P L   P     PP        PPPL      
Sbjct: 494  SLASHSPQAPLSSLIMPPLE-TQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAP 552

Query: 886  MTVPTLPSTAIPQPPPLQGTEM-LPPPPPPLPGAGIPPPPPLPGAGI------LPLPPLP 938
            +T P L +   P P PLQ     L  PPP  P +   PPP  P A        LP PPL 
Sbjct: 553  LTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLS 612

Query: 939  GAGIPPPPPLPGAAIPP--PPPLPGAGIPLPP---PLPGAG------------IPPPPPL 981
                PPP   P  A+PP   PP P A  PL P   P P A              PPP P 
Sbjct: 613  PLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP 672

Query: 982  PGAGIPPP--PPLPGAGIPPPPPLPGAGIPP--PPPLPGAGIPPPPPLPGAGIPPPPPLP 1037
              A   PP  PP+  +  PP    P    PP   PP P    P  PP+  +  PPP   P
Sbjct: 673  VQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSP----PASPPMSPSATPPPQAPP 728

Query: 1038 GAGIPP--PPPLPGAGIPPPPPLPGAGIPPP--PPL---PGAGIPPPPP--LPGAGIPPP 1088
                PP   PP P    P  PP+  +  PPP  PPL   P   +PP PP  LP + +  P
Sbjct: 729  PLAAPPLQVPPSP----PASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKP 784

Query: 1089 PPL--PGAGIPPPPPLPGVGIPPPPPLPG-AGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1145
            PP   P    PP   LP     PP   PG A   P   LP + +  PPP      PP   
Sbjct: 785  PPQAPPALATPPLQALPS----PPASFPGQAPFSPSASLPMSPLATPPPQA----PPVLA 836

Query: 1146 LPRVGIPPPPPL-PGAGIPPPPPLPG--------------AGIPPPPPL--PGVGIPPPP 1188
             P + +PP PP  P    P  PP PG              A  PPPPP   P   +  P 
Sbjct: 837  APLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPD 896

Query: 1189 ---------------------PLPGVGIPPPPPLPGAGIPPP-------PPLPGMGIP-- 1218
                                 P  G    PPP    A   P        PPL   G P  
Sbjct: 897  LAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGA 956

Query: 1219 PAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSG---LFGLG 1275
            P P PP   PG+      +    GP        S  P P      P P  SG     G G
Sbjct: 957  PLPWPPATGPGSADGLCTIYETEGP-------ESATPAPGALDPGPSPGTSGGKAAAGAG 1009

Query: 1276 MNQDKGSRKQ 1285
                  S KQ
Sbjct: 1010 AGASSRSPKQ 1019



 Score =  159 bits (401), Expect = 3e-38
 Identities = 164/527 (31%), Positives = 202/527 (38%), Gaps = 88/527 (16%)

Query: 795  SVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHS-ISTEFQTSHEHSVSSAFKNSC 853
            S  L +  P+ + ++P PPP    +A    P + PP   ++T    +      SA  +  
Sbjct: 301  SSPLATPSPSGTKARPVPPPD---NAATPLPATLPPSPPLATPLPLAPPSP--SAPPSLQ 355

Query: 854  NIPSPPPLPCTESSSSMPGLGMVPPPP-PPLPGMTVP---TLPSTAIPQPP----PLQGT 905
             +PSPP  P +++  SM    M  PP    +P + VP   T PS   P  P     LQ T
Sbjct: 356  TLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQAT 415

Query: 906  EMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGA-AIPPPPPLPGAGI 964
              L  P      + +   P    A  L  P  P +  P  PPL    ++P  PPL  +  
Sbjct: 416  TSLGSPTLQATHSFLTMSPRQTQAS-LTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLS 474

Query: 965  PLPPPLPG-------------AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1011
            P   PL               A   P  PL    I PP     +  PP    P A +  P
Sbjct: 475  PAVSPLSSPLTIHPLQALSSLASHSPQAPLSSL-IMPPLETQSSLAPPSLQTPPASLTTP 533

Query: 1012 PPLPGAGIPPPPPLPGAGIP--------PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1063
            P L       PPPL  A  P        PP P P     PP PL      PPP  P +  
Sbjct: 534  P-LENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLT----TPPPETPSSIA 588

Query: 1064 PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPP--PPPLPGAGIP-- 1119
             PPP  P A     PPL G    P PPL     PPP   P + +PP   PP P A  P  
Sbjct: 589  TPPPQAPPA--LASPPLQGL---PSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLS 643

Query: 1120 ----PPPPLPGA----------GIPPPPPLPGAGIPP-PPPLPRVGIPP---PPPL--PG 1159
                P P  P A            PP PP+     PP  PP+     PP   PP L  P 
Sbjct: 644  PLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPP 703

Query: 1160 AGIPPPPPL-----PGAGIPP--PPPL--PGVGIPPPPPLPGVGIPPPPPLPGAGIPPPP 1210
              +PP PP      P A  PP  PPPL  P + +PP P       P  PP+  +  PPP 
Sbjct: 704  LQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSP-------PASPPMSPSATPPPR 756

Query: 1211 PLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTP 1257
              P +  PP   PP PP    + P    P   PP L       LP+P
Sbjct: 757  VPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSP 803



 Score = 98.2 bits (243), Expect = 6e-20
 Identities = 142/523 (27%), Positives = 167/523 (31%), Gaps = 163/523 (31%)

Query: 889  PTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGIL---------PLP---- 935
            P  PS A+ +     GTE+    P P P A   PP   P   +          P P    
Sbjct: 169  PGTPSPAMARRSRAAGTEV--GLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARR 226

Query: 936  -PLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGA--GIPPP--- 989
             P  G G+  P     ++   P   P    P     P A   P  P P     + PP   
Sbjct: 227  RPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVT 286

Query: 990  PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1049
            PP   A  P   PL  + +  P P      P PPP   A      PLP A +PP PPL  
Sbjct: 287  PPRKDAA-PALGPLSSSPLATPSPSGTKARPVPPPDNAA-----TPLP-ATLPPSPPL-A 338

Query: 1050 AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP----PPL--- 1102
              +P  PP P A    PP L    +P PP  P +  PP    P    PP     PP+   
Sbjct: 339  TPLPLAPPSPSA----PPSLQT--LPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVP 392

Query: 1103 -----PGVGIPPPP-------------------------------------PLPGAGIPP 1120
                 P +  PP P                                     P   A  PP
Sbjct: 393  HSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPP 452

Query: 1121 --PPPLPGAGIPPPPPLPGAGIP------------------------PPPPLPRVGIPP- 1153
              PP      +P  PPL  +  P                        P  PL  + +PP 
Sbjct: 453  DSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPL 512

Query: 1154 -------PPPL--PGAGI--PP--------PPPLPGAGIP--------PPPPLPGVGIPP 1186
                   PP L  P A +  PP        PPPL  A  P        PP P P     P
Sbjct: 513  ETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAP 572

Query: 1187 PPPLPGVGIPPPPPLPGAGIPPPPPLPG-------MGIPPAPAPPLPPPGTGIPP----P 1235
            P PL      PPP  P +   PPP  P         G+P  P  PL  P    PP    P
Sbjct: 573  PSPL----TTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALP 628

Query: 1236 PLLPVSGPPLLPQVGSSTLPTPQV----------CGFLPPPLP 1268
            PL     PP  P +     P+PQ             F PPP P
Sbjct: 629  PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSP 671



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 125/440 (28%), Positives = 143/440 (32%), Gaps = 83/440 (18%)

Query: 895  AIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLP----- 949
            A  + P  +   +L P PP   G+  PPPP  P A    L  L  AG     PL      
Sbjct: 12   AAARTPAARAPGLLTPRPP---GSPRPPPPVTPAA----LRVLGAAGAVGRKPLAERAGG 64

Query: 950  --GAAIPPPPPLPGAGIPLPPPLPGAGIPPP---PPLPGAGIPPPPPLPGAGIPPPPPLP 1004
              GA IP   P  G     P    G     P   PP  G G   PP    +  P   P  
Sbjct: 65   IGGATIPESAPRAG-----PTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGR 119

Query: 1005 GAGIPPPPPLPGAGI---------------PPPPPLPGAGIPPPPPLPGAGIPPP----- 1044
             +G   P PL   G+                P      AG       P  G P P     
Sbjct: 120  ASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARR 179

Query: 1045 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGI---------PPPP-----PLPGAGIPPPPP 1090
                G  +  P P P A   PP   P   +          P P     P  G G+  P  
Sbjct: 180  SRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPAS 239

Query: 1091 LPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGA--GIPPP---PPLPGAGIPPPPP 1145
               +    P   P    P     P A   P  P P     + PP   PP   A  P   P
Sbjct: 240  RSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAA-PALGP 298

Query: 1146 LPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAG 1205
            L    +  P P      P PPP   A      PLP   +PP PPL    +P  PP P A 
Sbjct: 299  LSSSPLATPSPSGTKARPVPPPDNAA-----TPLPAT-LPPSPPL-ATPLPLAPPSPSA- 350

Query: 1206 IPPPPPLPGMGIPPAPAPPLPPPGTGIPP---PPLLPVSGPPLLPQVGSSTLPTPQVCGF 1262
               PP L  +  PPA  P   PP    PP   PP L    P  +P   S T P+ Q    
Sbjct: 351  ---PPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPH--SLTSPSLQA--- 402

Query: 1263 LPPPLPSGLFGLGMNQDKGS 1282
              PP P  L  L      GS
Sbjct: 403  --PPSPLALSSLQATTSLGS 420



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 97/332 (29%), Positives = 120/332 (36%), Gaps = 47/332 (14%)

Query: 232 PAAPPTA--VSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPRE 289
           PA+PP +   +P P A   L   LL         P SP  +   S  +  P S +A P  
Sbjct: 637 PASPPLSPLATPSPQAPNALAVHLLQ---APFSPPPSPPVQAPFSPPASPPVSPSATPPS 693

Query: 290 PQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEG 349
            Q PPS    P+   PS PA+ P    SPS+T  P P+A P    A  P++         
Sbjct: 694 -QAPPSLAAPPLQVPPSPPASPPM---SPSAT--PPPQAPP--PLAAPPLQVPPSPPASP 745

Query: 350 EEDAFEDAPRGSPGEEWAP--EVGEDAPQRLGEEP--EEEAQGPDA---PAAASLPGSPA 402
                   P   P    AP  +V    P  L   P  +   Q P A   P   +LP  PA
Sbjct: 746 PMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPA 805

Query: 403 --PSQRCFKPYPLITPCYIKTTTRQ---------LSSPNHSPSQSPNQSPRIKRRPEPSL 451
             P Q  F P   +    + T   Q         L  P   P+    Q+PR    P P  
Sbjct: 806 SFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDT 865

Query: 452 S-RGSRTALASVAAP------AKKHRADGGLAAGLSRSADWT-EEL-GARTPRVGGS--- 499
           S  G R  LA    P      +      G   AG S SA  T EEL G  +   GG+   
Sbjct: 866 SVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAAS 925

Query: 500 ----AHLLERGVASDSGGGVSPALAAKASGAP 527
               A L     A+ S G   P     A GAP
Sbjct: 926 PPPDAELAACHPAAWSRGPAPPLAFRGAPGAP 957



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 85/325 (26%), Positives = 118/325 (36%), Gaps = 47/325 (14%)

Query: 232  PAAPPTAVS----PQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEP 287
            PA+PP + S    PQ    L      + PS      P SP    + +    +P  LAA P
Sbjct: 711  PASPPMSPSATPPPQAPPPLAAPPLQVPPS-----PPASPPMSPSATPPPRVPPLLAAPP 765

Query: 288  REPQQPPSP-GGLPVSEAPSLPAAQPAAKDSPSSTAFP-----FPEAGPGEEAAGAPVRG 341
               Q PPSP   LP+S     P   P A  +P   A P     FP   P   +A  P+  
Sbjct: 766  L--QVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSP 823

Query: 342  AGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEE-PEEEAQGPDAPAAASLPGS 400
                  +          +  P    +P +   AP+R     P+    GP    A + PG 
Sbjct: 824  LATPPPQAPPVLAAPLLQVPPSPPASPTL--QAPRRPPTPGPDTSVSGPRLTLALA-PGP 880

Query: 401  PAPSQRCFKPYPLIT-------PCYIKTTTRQL----SSPNHSPSQSPNQSPRIKRRPEP 449
            P P  R   P   ++            +T  +L    S P    + SP     +      
Sbjct: 881  PPPPSR--SPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPA 938

Query: 450  SLSRGSRTALA---SVAAPAKKHRADG-GLAAGLSRSADWTEELGARTPRVGGSAHLLER 505
            + SRG    LA   +  AP     A G G A GL    + TE   + TP  G     L+ 
Sbjct: 939  AWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYE-TEGPESATPAPGA----LDP 993

Query: 506  GVASDSGGGVSPALAAKASGAPAAA 530
            G +  + GG     AA  +GA A++
Sbjct: 994  GPSPGTSGG----KAAAGAGAGASS 1014



 Score = 40.0 bits (92), Expect = 0.020
 Identities = 65/271 (23%), Positives = 94/271 (34%), Gaps = 37/271 (13%)

Query: 200 QQAIRLQQQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVSPQP---------GAFLGLD 250
           Q+ +R+  ++        +  ++     GA    + PT  +P P         G  +GL 
Sbjct: 131 QKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLP 190

Query: 251 RFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREP--QQPPSPGGLPVSEAPSLP 308
           R        A  A   P TE    ++S   E    EP     ++P + GGL         
Sbjct: 191 R-------PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGL--------- 234

Query: 309 AAQPAAKDSPSSTAFPFPE-AGPGEEAAGAPVRGAGDTDEEGEE-DAFEDAPRGSPGEEW 366
             Q  A  S SS+A P    A  G  A G P   A  +  + +   A        P ++ 
Sbjct: 235 --QRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDA 292

Query: 367 APEVGEDAPQRLGEEPEEEAQGPDAP----AAASLPGSPAPSQRCFKPYPLITPCYIKTT 422
           AP +G  +   L        +    P    AA  LP +  PS     P PL  P      
Sbjct: 293 APALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPP 352

Query: 423 TRQL--SSPNHSPSQSPNQSPRIKRRPEPSL 451
           + Q   S P   PSQ+P        +  PSL
Sbjct: 353 SLQTLPSPPATPPSQAPPSMTTPPMQAPPSL 383



 Score = 36.6 bits (83), Expect = 0.22
 Identities = 53/201 (26%), Positives = 75/201 (37%), Gaps = 20/201 (9%)

Query: 265 GSPDTEQALSALSDLPESLAAEPREPQQPPS-PGGLPVSEAP-SLPAAQPAAKD-SPSST 321
           GSP  +   S L+  P    A    P +P S P   P  +AP SLPA+ P     SP+ +
Sbjct: 419 GSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVS 478

Query: 322 AFPFPE--------AGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGED 373
               P         +     +  AP+        E +      + +  P     P + E+
Sbjct: 479 PLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPL-EN 537

Query: 374 APQRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSSPNHSP 433
            P  L   P + A  P        P  PAP      P PL TP     T   +++P   P
Sbjct: 538 LPS-LAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTP--PPETPSSIATP---P 591

Query: 434 SQSPN--QSPRIKRRPEPSLS 452
            Q+P    SP ++  P P LS
Sbjct: 592 PQAPPALASPPLQGLPSPPLS 612



 Score = 35.8 bits (81), Expect = 0.37
 Identities = 54/205 (26%), Positives = 63/205 (30%), Gaps = 34/205 (16%)

Query: 226  LQGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPG--------------SPDTEQ 271
            LQ    P A PT  +P+     G D  + GP      APG               PD   
Sbjct: 840  LQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAG 899

Query: 272  ALSALSDLPESLAAEPREPQQPPSPGGLPVSEAP--SLPAAQPAAKDSPSSTAFPFPEAG 329
              S+ +  PE L      P+     GG   S  P   L A  PAA     +    F    
Sbjct: 900  HSSSATSTPEELRGYDSGPE-----GGAAASPPPDAELAACHPAAWSRGPAPPLAF-RGA 953

Query: 330  PGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGP 389
            PG      P  G G  D  G    +E            PE    AP  L   P     G 
Sbjct: 954  PGAPLPWPPATGPGSAD--GLCTIYETE---------GPESATPAPGALDPGPSPGTSGG 1002

Query: 390  DAPAAASL-PGSPAPSQRCFKPYPL 413
             A A A     S +P Q      PL
Sbjct: 1003 KAAAGAGAGASSRSPKQARLGELPL 1027



 Score = 32.3 bits (72), Expect = 4.1
 Identities = 47/185 (25%), Positives = 54/185 (29%), Gaps = 10/185 (5%)

Query: 263 APGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAPSL----PAAQPAAKDSP 318
           AP    T  A      L       P   Q PPSP   P  E PS     P   P A  SP
Sbjct: 542 APPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASP 601

Query: 319 SSTAFPFPEAGP--GEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQ 376
                P P   P         P              A   +P  SP    +P+       
Sbjct: 602 PLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPA---SPPLSPLATPSPQAPNALAV 658

Query: 377 RLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSSPNHSPSQS 436
            L + P      P   A  S P SP P      P     P       +   SP  SP  S
Sbjct: 659 HLLQAPFSPPPSPPVQAPFSPPASP-PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMS 717

Query: 437 PNQSP 441
           P+ +P
Sbjct: 718 PSATP 722


>gi|33356148 formin-like 1 [Homo sapiens]
          Length = 1100

 Score =  182 bits (463), Expect = 2e-45
 Identities = 184/654 (28%), Positives = 261/654 (39%), Gaps = 121/654 (18%)

Query: 1045 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-----PPPPPLPGAGIPPP 1099
            PP P    P  P  P A       L   G+      PG  +     P     P  G  P 
Sbjct: 459  PPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPT 518

Query: 1100 PPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPG 1159
            P +P  G P P   P A      P PGA  PPPPPLPG  +P P   P    P  PPLPG
Sbjct: 519  PGVP-TGSPSPDLAPAA-----EPAPGAAPPPPPPLPG--LPSPQEAPPSAPPQAPPLPG 570

Query: 1160 AGIPPP-PPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIP 1218
            +  PPP PPLPG  +PPPP       PPPPP PG   P PPP      PPPPP       
Sbjct: 571  SPEPPPAPPLPG-DLPPPP-------PPPPPPPGTDGPVPPP------PPPPP------- 609

Query: 1219 PAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGLGMNQ 1278
                   PPPG    PP  L      L P V                             
Sbjct: 610  -------PPPG---GPPDALGRRDSELGPGV----------------------------- 630

Query: 1279 DKGSRKQPIEPCRPMKPLYWTRIQLHSKRDSSTSLIWEKIEEPSI----DCHEFEELFSK 1334
                 K+PI+    M  L W  +    K    T  ++ ++ +  +    D  +FEE F K
Sbjct: 631  ---KAKKPIQTKFRMPLLNWVAL----KPSQITGTVFTELNDEKVLQELDMSDFEEQF-K 682

Query: 1335 TAVKERKKPISDTISKT--KAKQVVKLLSNKRSQAVGILMSSLHLDMKDIQHAVVNLDNS 1392
            T  +     +S   SK   KA     L+   R++ + I +   +L  + I  A+   D  
Sbjct: 683  TKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQ 742

Query: 1393 VVDLETLQALYENRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYELSLIPNFSERVF 1452
             + L+ L+ L        E   I +  R  +  E    L + ++F+   S IP   ER+ 
Sbjct: 743  ALGLDFLELLMRFLPTEYERSLITRFEREQRPME---ELSEEDRFMLCFSRIPRLPERMT 799

Query: 1453 CILFQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNYMNGGNKTRGQAD 1512
             + F   F ++   +  +L  +     ++K+   + Q+L +VLAFGNYMN  +  RG A 
Sbjct: 800  TLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMN--SSKRGAAY 857

Query: 1513 GFGLDILPKLKDVKSSDNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLPEPQDLFQASQMK 1572
            GF L  L  L ++KS+D  ++LL Y+V      + +  G    L        L +A  + 
Sbjct: 858  GFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDL------HFLDKAGSVS 911

Query: 1573 FEDFQKDLRKLKKDLKACEVEAGKVYQ-VSSKEHMQPFKENMEQFIIQAKIDQEAEENSL 1631
             +    D+R L++ L+  + E  +    +  KE ++     M++ +  +K  QEA     
Sbjct: 912  LDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFLRANSPTMDKLLADSKTAQEA----- 966

Query: 1632 TETHKCFLETTAYFFMKPKLGEKEVSPNAFFSIWHEFSSDFK------DFWKKE 1679
                  F     YF   P    K  SP  FFS++  F   +K      + WKKE
Sbjct: 967  ------FESVVEYFGENP----KTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKE 1010



 Score =  112 bits (280), Expect = 3e-24
 Identities = 78/196 (39%), Positives = 89/196 (45%), Gaps = 29/196 (14%)

Query: 903  QGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGA 962
            + T M     PP P    P  P  P A  L +  L   G+      PG A+         
Sbjct: 449  ESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEI----- 503

Query: 963  GIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1022
             +P+    P  G  P P +P  G P P   P A      P PGA  PPPPPLPG  +P P
Sbjct: 504  -LPVAVATPSGGDAPTPGVP-TGSPSPDLAPAA-----EPAPGAAPPPPPPLPG--LPSP 554

Query: 1023 PPLPGAGIPPPPPLPGAGIPPP-PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1081
               P +  P  PPLPG+  PPP PPLPG  +PPPPP       PPPP PG   P PPP  
Sbjct: 555  QEAPPSAPPQAPPLPGSPEPPPAPPLPG-DLPPPPP-------PPPPPPGTDGPVPPP-- 604

Query: 1082 GAGIPPPPPLPGAGIP 1097
                PPPPP P  G P
Sbjct: 605  ----PPPPPPPPGGPP 616



 Score =  110 bits (274), Expect = 2e-23
 Identities = 77/192 (40%), Positives = 88/192 (45%), Gaps = 30/192 (15%)

Query: 866  SSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGT---EMLPPPPPPLPGAGIPP 922
            S S+  G    PP P   P    PT PS    +   L+      +L  P   +    +P 
Sbjct: 448  SESTAMGASRRPPEPEKAPP-AAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPV 506

Query: 923  PPPLPGAGILPLPPLPGAGIPPPP------PLPGAAIPPPPPLPGAGIPLPPPLPGAGIP 976
                P  G  P P +P  G P P       P PGAA PPPPPLPG  +P P   P +  P
Sbjct: 507  AVATPSGGDAPTPGVP-TGSPSPDLAPAAEPAPGAAPPPPPPLPG--LPSPQEAPPSAPP 563

Query: 977  PPPPLPGAGIPPP-PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1035
              PPLPG+  PPP PPLPG   PPPPP      PPPPP     +PPPP       PPPPP
Sbjct: 564  QAPPLPGSPEPPPAPPLPGDLPPPPPP------PPPPPGTDGPVPPPP-------PPPPP 610

Query: 1036 LPGAGIPPPPPL 1047
             PG    PP  L
Sbjct: 611  PPGG---PPDAL 619



 Score =  109 bits (273), Expect = 2e-23
 Identities = 76/187 (40%), Positives = 83/187 (44%), Gaps = 30/187 (16%)

Query: 968  PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-----PPPPPLPGAGIPPP 1022
            PP P    P  P  P A       L   G+      PG  +     P     P  G  P 
Sbjct: 459  PPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPT 518

Query: 1023 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1082
            P +P  G P P   P A      P PGA  PPPPPLPG  +P P   P +  P  PPLPG
Sbjct: 519  PGVP-TGSPSPDLAPAA-----EPAPGAAPPPPPPLPG--LPSPQEAPPSAPPQAPPLPG 570

Query: 1083 AGIPPP-PPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1141
            +  PPP PPLPG   PPPPP      PPPPP     +PPPP       PPPPP PG    
Sbjct: 571  SPEPPPAPPLPGDLPPPPPP------PPPPPGTDGPVPPPP-------PPPPPPPGG--- 614

Query: 1142 PPPPLPR 1148
            PP  L R
Sbjct: 615  PPDALGR 621



 Score =  109 bits (273), Expect = 2e-23
 Identities = 76/185 (41%), Positives = 83/185 (44%), Gaps = 30/185 (16%)

Query: 946  PPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGI-----PPPPPLPGAGIPPP 1000
            PP P  A P  P  P A       L   G+      PG  +     P     P  G  P 
Sbjct: 459  PPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPT 518

Query: 1001 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1060
            P +P  G P P   P A      P PGA  PPPPPLPG  +P P   P +  P  PPLPG
Sbjct: 519  PGVP-TGSPSPDLAPAA-----EPAPGAAPPPPPPLPG--LPSPQEAPPSAPPQAPPLPG 570

Query: 1061 AGIPPP-PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIP 1119
            +  PPP PPLPG   PPPPP      PPPPP     +PPPP       PPPPP PG    
Sbjct: 571  SPEPPPAPPLPGDLPPPPPP------PPPPPGTDGPVPPPP-------PPPPPPPGG--- 614

Query: 1120 PPPPL 1124
            PP  L
Sbjct: 615  PPDAL 619



 Score =  108 bits (271), Expect = 3e-23
 Identities = 72/176 (40%), Positives = 79/176 (44%), Gaps = 27/176 (15%)

Query: 935  PPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGI-----PPPPPLPGAGIPPP 989
            PP P    P  P  P A       L   G+      PG  +     P     P  G  P 
Sbjct: 459  PPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPT 518

Query: 990  PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1049
            P +P  G P P   P A      P PGA  PPPPPLPG  +P P   P +  P  PPLPG
Sbjct: 519  PGVP-TGSPSPDLAPAA-----EPAPGAAPPPPPPLPG--LPSPQEAPPSAPPQAPPLPG 570

Query: 1050 AGIPPP-PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1104
            +  PPP PPLPG   PPPPP      PPPPP     +PPPP       PPPPP PG
Sbjct: 571  SPEPPPAPPLPGDLPPPPPP------PPPPPGTDGPVPPPP-------PPPPPPPG 613



 Score =  107 bits (268), Expect = 8e-23
 Identities = 72/176 (40%), Positives = 79/176 (44%), Gaps = 27/176 (15%)

Query: 1012 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-----PPPPPLPGAGIPPP 1066
            PP P    P  P  P A       L   G+      PG  +     P     P  G  P 
Sbjct: 459  PPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPT 518

Query: 1067 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPG 1126
            P +P  G P P   P A      P PGA  PPPPPLPG  +P P   P +  P  PPLPG
Sbjct: 519  PGVP-TGSPSPDLAPAA-----EPAPGAAPPPPPPLPG--LPSPQEAPPSAPPQAPPLPG 570

Query: 1127 AGIPPP-PPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1181
            +  PPP PPLPG   PPPPP      PPPPP     +PPPP       PPPPP PG
Sbjct: 571  SPEPPPAPPLPGDLPPPPPP------PPPPPGTDGPVPPPP-------PPPPPPPG 613



 Score =  105 bits (263), Expect = 3e-22
 Identities = 75/185 (40%), Positives = 81/185 (43%), Gaps = 30/185 (16%)

Query: 1001 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-----PPPPPLPGAGIPPP 1055
            PP P    P  P  P A       L   G+      PG  +     P     P  G  P 
Sbjct: 459  PPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPT 518

Query: 1056 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPG 1115
            P +P  G P P   P A      P PGA  PPPPPLPG  +P P   P    P  PPLPG
Sbjct: 519  PGVP-TGSPSPDLAPAA-----EPAPGAAPPPPPPLPG--LPSPQEAPPSAPPQAPPLPG 570

Query: 1116 AGIPPP-PPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIP 1174
            +  PPP PPLPG   PPPPP      PPPPP     +PPPP       PPPPP PG    
Sbjct: 571  SPEPPPAPPLPGDLPPPPPP------PPPPPGTDGPVPPPP-------PPPPPPPGG--- 614

Query: 1175 PPPPL 1179
            PP  L
Sbjct: 615  PPDAL 619



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 70/202 (34%), Positives = 85/202 (42%), Gaps = 36/202 (17%)

Query: 800 SHQPTQSISQPPPPPSLLWSAGQGQPGSQP--PHSISTEFQTSHEHSVSSAFKNSCNIPS 857
           S       S+ PP P       +  P + P  P ++  + +   E  +    +   +  S
Sbjct: 448 SESTAMGASRRPPEP-------EKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVS 500

Query: 858 PPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPG 917
              LP   ++   P  G  P P  P  G   P L   A P P         PPPPPPLPG
Sbjct: 501 IEILPVAVAT---PSGGDAPTPGVPT-GSPSPDLAPAAEPAPGAA------PPPPPPLPG 550

Query: 918 AGIPPPPPLPGAGILPLPPLPGAGIPPP-PPLPGAAIPPPPPLPGAGIPLPPPLPGAGIP 976
             +P P   P +     PPLPG+  PPP PPLPG   PPPPP        PPP PG   P
Sbjct: 551 --LPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPP--------PPPPPGTDGP 600

Query: 977 PPPPLPGAGIPPPPPLPGAGIP 998
            PPP      PPPPP P  G P
Sbjct: 601 VPPP------PPPPPPPPGGPP 616



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 85/324 (26%), Positives = 116/324 (35%), Gaps = 97/324 (29%)

Query: 642 ETESQSAVSETPQKRSDAVQKEVVDMKSEGQATVIQQLEQTIEDLRTKIAELERQYPALD 701
           +TE+++AV E  ++  + V            A + ++L     +   KIAELE+Q     
Sbjct: 390 DTETKNAVLEHMEELQEQV------------ALLTERLRDAENESMAKIAELEKQLSQAR 437

Query: 702 TEVASGHQGLENGVTASGDVCLEALRLEEKEVRHHRILEAKSIQTSPTEEGGVLTLPPVD 761
            E+ +  +      TA G         E+          A  ++    EE G++ +    
Sbjct: 438 KELETLRERFSES-TAMG-ASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRI---- 491

Query: 762 GLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAG 821
            L G     PG            +S+ + P  ++       PT  +    P P L   A 
Sbjct: 492 -LRG-----PG----------DAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLA-PAA 534

Query: 822 QGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPP 881
           +  PG+ P                          P PPPLP   S    P     PP  P
Sbjct: 535 EPAPGAAP--------------------------PPPPPLPGLPSPQEAP--PSAPPQAP 566

Query: 882 PLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAG 941
           PLPG           P+PPP           PPLPG  +PPPPP       P PP PG  
Sbjct: 567 PLPGS----------PEPPP----------APPLPG-DLPPPPP-------PPPPPPGTD 598

Query: 942 IPPPPPLPGAAIPPPPPLPGAGIP 965
            P PPP      PPPPP P  G P
Sbjct: 599 GPVPPP------PPPPPPPPGGPP 616



 Score = 38.9 bits (89), Expect = 0.044
 Identities = 33/108 (30%), Positives = 37/108 (34%), Gaps = 12/108 (11%)

Query: 233 AAPPTAVSPQPGAFLGLDRFLLGPSG--GAGEAPGSPDTEQALSALSDLPES-------L 283
           A P    +P PG   G     L P+     G AP  P     L +  + P S       L
Sbjct: 509 ATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPL 568

Query: 284 AAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPG 331
              P  P  PP PG LP    P  P   P   D P     P P   PG
Sbjct: 569 PGSPEPPPAPPLPGDLP---PPPPPPPPPPGTDGPVPPPPPPPPPPPG 613



 Score = 37.0 bits (84), Expect = 0.17
 Identities = 35/112 (31%), Positives = 39/112 (34%), Gaps = 12/112 (10%)

Query: 226 LQGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAP---GSPDTEQALSALSDLPES 282
           L  A EPA  P A  P P    GL      P     +AP   GSP+   A     DLP  
Sbjct: 530 LAPAAEPA--PGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPP 587

Query: 283 LAAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEA 334
                  P  PP P G      P  P   P     P +      E GPG +A
Sbjct: 588 -------PPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRRDSELGPGVKA 632



 Score = 32.7 bits (73), Expect = 3.1
 Identities = 36/159 (22%), Positives = 50/159 (31%), Gaps = 41/159 (25%)

Query: 291 QQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGE 350
           ++PP P   P + AP+ P+A     +            GPG+ A    +         G 
Sbjct: 457 RRPPEPEKAPPA-APTRPSALELKVEELEEKGLIRILRGPGD-AVSIEILPVAVATPSGG 514

Query: 351 EDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKP 410
           +      P GSP  + AP               E A G   P    LPG P         
Sbjct: 515 DAPTPGVPTGSPSPDLAPAA-------------EPAPGAAPPPPPPLPGLP--------- 552

Query: 411 YPLITPCYIKTTTRQLSSPNHSPSQSPNQSPRIKRRPEP 449
                            SP  +P  +P Q+P +   PEP
Sbjct: 553 -----------------SPQEAPPSAPPQAPPLPGSPEP 574


>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
          Length = 1096

 Score =  180 bits (456), Expect = 1e-44
 Identities = 161/566 (28%), Positives = 259/566 (45%), Gaps = 85/566 (15%)

Query: 1171 AGIPPPP---PLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGM-GIPPAPAPPLP 1226
            +GIP PP   PLPGVG PPPPP P   +P   PLP    PPPPPLPGM GIPP       
Sbjct: 546  SGIPGPPAAPPLPGVGPPPPPPAPP--LPGGAPLP----PPPPPLPGMMGIPP------- 592

Query: 1227 PPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGSR-KQ 1285
                  PPPP L   GPP          P P + G  PPP      G+ +N   G + K+
Sbjct: 593  ------PPPPPLLFGGPP----------PPPPLGGVPPPP------GISLNLPYGMKQKK 630

Query: 1286 PIEPCRPMKPLYWTRIQLHSKRDSSTSLIWEKIEEPSIDCHEFEELFSK------TAVKE 1339
              +P   MK + W++I+     + S +  W +++E   D  E  +LF+K      T +K 
Sbjct: 631  MYKPEVSMKRINWSKIE---PTELSENCFWLRVKE---DKFENPDLFAKLALNFATQIKV 684

Query: 1340 RKKPISDTISKT----KAKQVVKLLSNKRSQAVGILMSSLHLDMKDIQHAVVNLDNSVVD 1395
            +K   +    KT    K  + +++L  K +Q + I + S  +  +DI++ ++ ++  ++ 
Sbjct: 685  QKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLS 744

Query: 1396 LETLQALYENRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYELSLIPNFSERVFCIL 1455
               +Q L ++  +   L ++      ++ K     L +PEQF   +S +     R+  IL
Sbjct: 745  EALIQNLVKHLPEQKILNEL------AELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSIL 798

Query: 1456 FQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNYMNGGNKTRGQADGFG 1515
            F+ TF E I +I+  +  +   CE LK      ++L LVL  GNYMN G++   Q+ GF 
Sbjct: 799  FKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSR-NAQSLGFK 857

Query: 1516 LDILPKLKDVKSSDNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLPEPQDLFQASQMKFED 1575
            ++ L K++D KS+D   +LL     +++ +  E+  ++   FP  E + +  AS++  + 
Sbjct: 858  INFLCKIRDTKSADQKTTLL-----HFIADICEEKYRDILKFP-EELEHVESASKVSAQI 911

Query: 1576 FQKDLRKLKKDLKACEVEAGKVYQVSSKEHMQPFKENMEQFIIQAKIDQEAEENSLTETH 1635
             + +L  +++ +   E +  K  Q  ++     F E M  F   A+   E          
Sbjct: 912  LKSNLASMEQQIVHLERDIKKFPQAENQH--DKFVEKMTSFTKTAREQYEKLSTMHNNMM 969

Query: 1636 KCFLETTAYFFMKPKLGEKEVSPNAFFSIWHEFSSDFKDFWKKENK----------LLLQ 1685
            K +     YF        K VS   FF   + F + F +  ++ NK            L 
Sbjct: 970  KLYENLGEYFI----FDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLA 1025

Query: 1686 ERVKEAEEVCRQKKGKSLYKIKPRHD 1711
            +   E E++ RQKK K L  I    D
Sbjct: 1026 KEKAEQEKLERQKKKKQLIDINKEGD 1051



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 55/107 (51%), Positives = 57/107 (53%), Gaps = 37/107 (34%)

Query: 918  AGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPP 977
            +GIP PP  P        PLPG G PPPPP P        PLPG G PLP        PP
Sbjct: 546  SGIPGPPAAP--------PLPGVGPPPPPPAP--------PLPG-GAPLP--------PP 580

Query: 978  PPPLPG-AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1023
            PPPLPG  GIPP         PPPPPL   G PPPPPL   G+PPPP
Sbjct: 581  PPPLPGMMGIPP---------PPPPPLLFGGPPPPPPL--GGVPPPP 616



 Score = 89.4 bits (220), Expect = 3e-17
 Identities = 47/79 (59%), Positives = 50/79 (63%), Gaps = 14/79 (17%)

Query: 1094 AGIPPPP---PLPGVGIPPPPPLPGAGIPPPPPLPGAG--IPPPPPLPG-AGIPPPPPLP 1147
            +GIP PP   PLPGVG PPPPP P        PLPG     PPPPPLPG  GIPPPPP P
Sbjct: 546  SGIPGPPAAPPLPGVGPPPPPPAP--------PLPGGAPLPPPPPPLPGMMGIPPPPPPP 597

Query: 1148 RVGIPPPPPLPGAGIPPPP 1166
             +   PPPP P  G+PPPP
Sbjct: 598  LLFGGPPPPPPLGGVPPPP 616



 Score = 88.6 bits (218), Expect = 5e-17
 Identities = 50/88 (56%), Positives = 53/88 (60%), Gaps = 21/88 (23%)

Query: 973  AGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA-GIPPPPPLPGA 1028
            +GIP PP   PLPG G PPPPP P   +P   PLP    PPPPPLPG  GIPP       
Sbjct: 546  SGIPGPPAAPPLPGVGPPPPPPAPP--LPGGAPLP----PPPPPLPGMMGIPP------- 592

Query: 1029 GIPPPPPLPGAGIPPPPPLPGAGIPPPP 1056
              PPPPPL   G PPPPPL   G+PPPP
Sbjct: 593  --PPPPPLLFGGPPPPPPL--GGVPPPP 616



 Score = 88.6 bits (218), Expect = 5e-17
 Identities = 53/99 (53%), Positives = 55/99 (55%), Gaps = 32/99 (32%)

Query: 995  AGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-A 1050
            +GIP PP   PLPG G PPPPP P        PLPG       PLP    PPPPPLPG  
Sbjct: 546  SGIPGPPAAPPLPGVGPPPPPPAP--------PLPGGA-----PLP----PPPPPLPGMM 588

Query: 1051 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1089
            GIPPPP         PPPL   G PPPPPL   G+PPPP
Sbjct: 589  GIPPPP---------PPPLLFGGPPPPPPL--GGVPPPP 616



 Score = 88.6 bits (218), Expect = 5e-17
 Identities = 50/88 (56%), Positives = 53/88 (60%), Gaps = 21/88 (23%)

Query: 1050 AGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA-GIPPPPPLPGV 1105
            +GIP PP   PLPG G PPPPP P   +P   PLP    PPPPPLPG  GIPPPP     
Sbjct: 546  SGIPGPPAAPPLPGVGPPPPPPAPP--LPGGAPLP----PPPPPLPGMMGIPPPP----- 594

Query: 1106 GIPPPPPLPGAGIPPPPPLPGAGIPPPP 1133
                PPPL   G PPPPPL   G+PPPP
Sbjct: 595  ----PPPLLFGGPPPPPPL--GGVPPPP 616



 Score = 88.2 bits (217), Expect = 6e-17
 Identities = 48/84 (57%), Positives = 50/84 (59%), Gaps = 18/84 (21%)

Query: 963  GIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-AGIPPPPPLPGAGIPP 1021
            G P  PPLPG G PPPPP P   +P   PLP    PPPPPLPG  GIPP         PP
Sbjct: 550  GPPAAPPLPGVGPPPPPPAPP--LPGGAPLP----PPPPPLPGMMGIPP---------PP 594

Query: 1022 PPPLPGAGIPPPPPLPGAGIPPPP 1045
            PPPL   G PPPPPL   G+PPPP
Sbjct: 595  PPPLLFGGPPPPPPL--GGVPPPP 616



 Score = 87.8 bits (216), Expect = 8e-17
 Identities = 50/88 (56%), Positives = 53/88 (60%), Gaps = 21/88 (23%)

Query: 1072 AGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPG-AGIPPPPPLPGA 1127
            +GIP PP   PLPG G PPPPP P   +P   PLP    PPPPPLPG  GIPP       
Sbjct: 546  SGIPGPPAAPPLPGVGPPPPPPAPP--LPGGAPLP----PPPPPLPGMMGIPP------- 592

Query: 1128 GIPPPPPLPGAGIPPPPPLPRVGIPPPP 1155
              PPPPPL   G PPPPPL   G+PPPP
Sbjct: 593  --PPPPPLLFGGPPPPPPLG--GVPPPP 616



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 53/103 (51%), Positives = 57/103 (55%), Gaps = 24/103 (23%)

Query: 866 SSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPG-AGIPPPP 924
           SSS +PG    PP  PPLPG+  P  P       PPL G   LPPPPPPLPG  GIPPPP
Sbjct: 544 SSSGIPG----PPAAPPLPGVGPPPPPPA-----PPLPGGAPLPPPPPPLPGMMGIPPPP 594

Query: 925 PLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLP 967
           P         PPL   G PPPPPL G  +PPP   PG  + LP
Sbjct: 595 P---------PPLLFGGPPPPPPLGG--VPPP---PGISLNLP 623



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 53/99 (53%), Positives = 55/99 (55%), Gaps = 32/99 (32%)

Query: 1028 AGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-A 1083
            +GIP PP   PLPG G PPPPP P        PLPG       PLP    PPPPPLPG  
Sbjct: 546  SGIPGPPAAPPLPGVGPPPPPPAP--------PLPGGA-----PLP----PPPPPLPGMM 588

Query: 1084 GIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPP 1122
            GIPPPP         PPPL   G PPPPPL   G+PPPP
Sbjct: 589  GIPPPP---------PPPLLFGGPPPPPPL--GGVPPPP 616



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 48/85 (56%), Positives = 49/85 (57%), Gaps = 22/85 (25%)

Query: 909 PPPPPPLPGAGIPPPPPLPGAGILPLP---PLPGAGIPPPPPLPGAAIPPPPPLPGAGIP 965
           PP  PPLPG G PPPPP P     PLP   PLP    PPPPPLPG    PPPP       
Sbjct: 551 PPAAPPLPGVGPPPPPPAP-----PLPGGAPLP----PPPPPLPGMMGIPPPP------- 594

Query: 966 LPPPLPGAGIPPPPPLPGAGIPPPP 990
            PPPL   G PPPPPL   G+PPPP
Sbjct: 595 -PPPLLFGGPPPPPPL--GGVPPPP 616



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 43/143 (30%), Positives = 48/143 (33%), Gaps = 75/143 (52%)

Query: 803 PTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLP 862
           P   +  PPPPP+                                           PPLP
Sbjct: 556 PLPGVGPPPPPPA-------------------------------------------PPLP 572

Query: 863 CTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPP 922
                    G   +PPPPPPLPGM         IP           PPPPPPL   G PP
Sbjct: 573 ---------GGAPLPPPPPPLPGM-------MGIP-----------PPPPPPLLFGGPPP 605

Query: 923 PPPLPGAGILPLPPLPGAGIPPP 945
           PPPL G     +PP PG  +  P
Sbjct: 606 PPPLGG-----VPPPPGISLNLP 623


>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
          Length = 1101

 Score =  180 bits (456), Expect = 1e-44
 Identities = 161/566 (28%), Positives = 259/566 (45%), Gaps = 85/566 (15%)

Query: 1171 AGIPPPP---PLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGM-GIPPAPAPPLP 1226
            +GIP PP   PLPGVG PPPPP P   +P   PLP    PPPPPLPGM GIPP       
Sbjct: 546  SGIPGPPAAPPLPGVGPPPPPPAPP--LPGGAPLP----PPPPPLPGMMGIPP------- 592

Query: 1227 PPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGSR-KQ 1285
                  PPPP L   GPP          P P + G  PPP      G+ +N   G + K+
Sbjct: 593  ------PPPPPLLFGGPP----------PPPPLGGVPPPP------GISLNLPYGMKQKK 630

Query: 1286 PIEPCRPMKPLYWTRIQLHSKRDSSTSLIWEKIEEPSIDCHEFEELFSK------TAVKE 1339
              +P   MK + W++I+     + S +  W +++E   D  E  +LF+K      T +K 
Sbjct: 631  MYKPEVSMKRINWSKIE---PTELSENCFWLRVKE---DKFENPDLFAKLALNFATQIKV 684

Query: 1340 RKKPISDTISKT----KAKQVVKLLSNKRSQAVGILMSSLHLDMKDIQHAVVNLDNSVVD 1395
            +K   +    KT    K  + +++L  K +Q + I + S  +  +DI++ ++ ++  ++ 
Sbjct: 685  QKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLS 744

Query: 1396 LETLQALYENRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYELSLIPNFSERVFCIL 1455
               +Q L ++  +   L ++      ++ K     L +PEQF   +S +     R+  IL
Sbjct: 745  EALIQNLVKHLPEQKILNEL------AELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSIL 798

Query: 1456 FQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNYMNGGNKTRGQADGFG 1515
            F+ TF E I +I+  +  +   CE LK      ++L LVL  GNYMN G++   Q+ GF 
Sbjct: 799  FKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSR-NAQSLGFK 857

Query: 1516 LDILPKLKDVKSSDNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLPEPQDLFQASQMKFED 1575
            ++ L K++D KS+D   +LL     +++ +  E+  ++   FP  E + +  AS++  + 
Sbjct: 858  INFLCKIRDTKSADQKTTLL-----HFIADICEEKYRDILKFP-EELEHVESASKVSAQI 911

Query: 1576 FQKDLRKLKKDLKACEVEAGKVYQVSSKEHMQPFKENMEQFIIQAKIDQEAEENSLTETH 1635
             + +L  +++ +   E +  K  Q  ++     F E M  F   A+   E          
Sbjct: 912  LKSNLASMEQQIVHLERDIKKFPQAENQH--DKFVEKMTSFTKTAREQYEKLSTMHNNMM 969

Query: 1636 KCFLETTAYFFMKPKLGEKEVSPNAFFSIWHEFSSDFKDFWKKENK----------LLLQ 1685
            K +     YF        K VS   FF   + F + F +  ++ NK            L 
Sbjct: 970  KLYENLGEYFI----FDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLA 1025

Query: 1686 ERVKEAEEVCRQKKGKSLYKIKPRHD 1711
            +   E E++ RQKK K L  I    D
Sbjct: 1026 KEKAEQEKLERQKKKKQLIDINKEGD 1051



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 55/107 (51%), Positives = 57/107 (53%), Gaps = 37/107 (34%)

Query: 918  AGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPP 977
            +GIP PP  P        PLPG G PPPPP P        PLPG G PLP        PP
Sbjct: 546  SGIPGPPAAP--------PLPGVGPPPPPPAP--------PLPG-GAPLP--------PP 580

Query: 978  PPPLPG-AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1023
            PPPLPG  GIPP         PPPPPL   G PPPPPL   G+PPPP
Sbjct: 581  PPPLPGMMGIPP---------PPPPPLLFGGPPPPPPL--GGVPPPP 616



 Score = 89.4 bits (220), Expect = 3e-17
 Identities = 47/79 (59%), Positives = 50/79 (63%), Gaps = 14/79 (17%)

Query: 1094 AGIPPPP---PLPGVGIPPPPPLPGAGIPPPPPLPGAG--IPPPPPLPG-AGIPPPPPLP 1147
            +GIP PP   PLPGVG PPPPP P        PLPG     PPPPPLPG  GIPPPPP P
Sbjct: 546  SGIPGPPAAPPLPGVGPPPPPPAP--------PLPGGAPLPPPPPPLPGMMGIPPPPPPP 597

Query: 1148 RVGIPPPPPLPGAGIPPPP 1166
             +   PPPP P  G+PPPP
Sbjct: 598  LLFGGPPPPPPLGGVPPPP 616



 Score = 88.6 bits (218), Expect = 5e-17
 Identities = 50/88 (56%), Positives = 53/88 (60%), Gaps = 21/88 (23%)

Query: 973  AGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA-GIPPPPPLPGA 1028
            +GIP PP   PLPG G PPPPP P   +P   PLP    PPPPPLPG  GIPP       
Sbjct: 546  SGIPGPPAAPPLPGVGPPPPPPAPP--LPGGAPLP----PPPPPLPGMMGIPP------- 592

Query: 1029 GIPPPPPLPGAGIPPPPPLPGAGIPPPP 1056
              PPPPPL   G PPPPPL   G+PPPP
Sbjct: 593  --PPPPPLLFGGPPPPPPL--GGVPPPP 616



 Score = 88.6 bits (218), Expect = 5e-17
 Identities = 53/99 (53%), Positives = 55/99 (55%), Gaps = 32/99 (32%)

Query: 995  AGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-A 1050
            +GIP PP   PLPG G PPPPP P        PLPG       PLP    PPPPPLPG  
Sbjct: 546  SGIPGPPAAPPLPGVGPPPPPPAP--------PLPGGA-----PLP----PPPPPLPGMM 588

Query: 1051 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1089
            GIPPPP         PPPL   G PPPPPL   G+PPPP
Sbjct: 589  GIPPPP---------PPPLLFGGPPPPPPL--GGVPPPP 616



 Score = 88.6 bits (218), Expect = 5e-17
 Identities = 50/88 (56%), Positives = 53/88 (60%), Gaps = 21/88 (23%)

Query: 1050 AGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA-GIPPPPPLPGV 1105
            +GIP PP   PLPG G PPPPP P   +P   PLP    PPPPPLPG  GIPPPP     
Sbjct: 546  SGIPGPPAAPPLPGVGPPPPPPAPP--LPGGAPLP----PPPPPLPGMMGIPPPP----- 594

Query: 1106 GIPPPPPLPGAGIPPPPPLPGAGIPPPP 1133
                PPPL   G PPPPPL   G+PPPP
Sbjct: 595  ----PPPLLFGGPPPPPPL--GGVPPPP 616



 Score = 88.2 bits (217), Expect = 6e-17
 Identities = 48/84 (57%), Positives = 50/84 (59%), Gaps = 18/84 (21%)

Query: 963  GIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-AGIPPPPPLPGAGIPP 1021
            G P  PPLPG G PPPPP P   +P   PLP    PPPPPLPG  GIPP         PP
Sbjct: 550  GPPAAPPLPGVGPPPPPPAPP--LPGGAPLP----PPPPPLPGMMGIPP---------PP 594

Query: 1022 PPPLPGAGIPPPPPLPGAGIPPPP 1045
            PPPL   G PPPPPL   G+PPPP
Sbjct: 595  PPPLLFGGPPPPPPL--GGVPPPP 616



 Score = 87.8 bits (216), Expect = 8e-17
 Identities = 50/88 (56%), Positives = 53/88 (60%), Gaps = 21/88 (23%)

Query: 1072 AGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPG-AGIPPPPPLPGA 1127
            +GIP PP   PLPG G PPPPP P   +P   PLP    PPPPPLPG  GIPP       
Sbjct: 546  SGIPGPPAAPPLPGVGPPPPPPAPP--LPGGAPLP----PPPPPLPGMMGIPP------- 592

Query: 1128 GIPPPPPLPGAGIPPPPPLPRVGIPPPP 1155
              PPPPPL   G PPPPPL   G+PPPP
Sbjct: 593  --PPPPPLLFGGPPPPPPLG--GVPPPP 616



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 53/103 (51%), Positives = 57/103 (55%), Gaps = 24/103 (23%)

Query: 866 SSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPG-AGIPPPP 924
           SSS +PG    PP  PPLPG+  P  P       PPL G   LPPPPPPLPG  GIPPPP
Sbjct: 544 SSSGIPG----PPAAPPLPGVGPPPPPPA-----PPLPGGAPLPPPPPPLPGMMGIPPPP 594

Query: 925 PLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLP 967
           P         PPL   G PPPPPL G  +PPP   PG  + LP
Sbjct: 595 P---------PPLLFGGPPPPPPLGG--VPPP---PGISLNLP 623



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 53/99 (53%), Positives = 55/99 (55%), Gaps = 32/99 (32%)

Query: 1028 AGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-A 1083
            +GIP PP   PLPG G PPPPP P        PLPG       PLP    PPPPPLPG  
Sbjct: 546  SGIPGPPAAPPLPGVGPPPPPPAP--------PLPGGA-----PLP----PPPPPLPGMM 588

Query: 1084 GIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPP 1122
            GIPPPP         PPPL   G PPPPPL   G+PPPP
Sbjct: 589  GIPPPP---------PPPLLFGGPPPPPPL--GGVPPPP 616



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 48/85 (56%), Positives = 49/85 (57%), Gaps = 22/85 (25%)

Query: 909 PPPPPPLPGAGIPPPPPLPGAGILPLP---PLPGAGIPPPPPLPGAAIPPPPPLPGAGIP 965
           PP  PPLPG G PPPPP P     PLP   PLP    PPPPPLPG    PPPP       
Sbjct: 551 PPAAPPLPGVGPPPPPPAP-----PLPGGAPLP----PPPPPLPGMMGIPPPP------- 594

Query: 966 LPPPLPGAGIPPPPPLPGAGIPPPP 990
            PPPL   G PPPPPL   G+PPPP
Sbjct: 595 -PPPLLFGGPPPPPPL--GGVPPPP 616



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 43/143 (30%), Positives = 48/143 (33%), Gaps = 75/143 (52%)

Query: 803 PTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLP 862
           P   +  PPPPP+                                           PPLP
Sbjct: 556 PLPGVGPPPPPPA-------------------------------------------PPLP 572

Query: 863 CTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPP 922
                    G   +PPPPPPLPGM         IP           PPPPPPL   G PP
Sbjct: 573 ---------GGAPLPPPPPPLPGM-------MGIP-----------PPPPPPLLFGGPPP 605

Query: 923 PPPLPGAGILPLPPLPGAGIPPP 945
           PPPL G     +PP PG  +  P
Sbjct: 606 PPPLGG-----VPPPPGISLNLP 623


>gi|21071077 dishevelled-associated activator of morphogenesis 1 [Homo
            sapiens]
          Length = 1078

 Score =  177 bits (449), Expect = 8e-44
 Identities = 155/567 (27%), Positives = 258/567 (45%), Gaps = 87/567 (15%)

Query: 1171 AGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGT 1230
            A IP  P     G P P  +PG  +PPPPP         PPLPG  +PP P PPLPP G 
Sbjct: 525  ASIPGGPSPGAPGGPFPSSVPGSLLPPPPP---------PPLPGGMLPPPP-PPLPPGGP 574

Query: 1231 GIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIEPC 1290
              PPPP     GPP L              G + PP P    GL +      +K   +P 
Sbjct: 575  --PPPP-----GPPPL--------------GAIMPP-PGAPMGLALK-----KKSIPQPT 607

Query: 1291 RPMKPLYWTRIQLHSKRDSSTSLIWEKIEEPSI----DCHEFEELFS-----------KT 1335
              +K   W+++      +     +W +I++  +    D  + E  FS             
Sbjct: 608  NALKSFNWSKLP----ENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFFVNSN 663

Query: 1336 AVKERKKPISDTISKTKAKQVVKLLSNKRSQAVGILMSSLHLDMKDIQHAVVNLDNSV-V 1394
            + ++    I DT+S     + + ++  +R+Q   IL+S L L   +I+ A++ +D    +
Sbjct: 664  SKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDL 723

Query: 1395 DLETLQALYENRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYELSLIPNFSERVFCI 1454
              + L+ L +   +  +++ +E+H      K     + K ++FL+E+S I ++ +R+  +
Sbjct: 724  PKDMLEQLLKFVPEKSDIDLLEEH------KHELDRMAKADRFLFEMSRINHYQQRLQSL 777

Query: 1455 LFQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNYMNGGNKTRGQADGF 1514
             F+  F+E +  ++ K+E ++   E +     + Q+L +VLAFGNYMN G   RG A GF
Sbjct: 778  YFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQ--RGNAYGF 835

Query: 1515 GLDILPKLKDVKSS-DNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLPEPQDLFQASQMKF 1573
             +  L K+ D KSS D + +LL Y+++     +       +      E +D+ QA+++  
Sbjct: 836  KISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNE------ELRDIPQAAKVNM 889

Query: 1574 EDFQKDLRKLKKDLKACEVEAGKVYQVSS-KEHMQPFKENMEQFIIQAKIDQEAEENSLT 1632
             +  K++  L+  LKA E E    YQ S   +    F   + QFI  A       E+ L 
Sbjct: 890  TELDKEISTLRSGLKAVETEL--EYQKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLA 947

Query: 1633 ETHKCFLETTAYFFMKPKLGEK--EVSPNAFFSIWHEFSSDFKDFWKKENKLLLQERVKE 1690
            E    F +   +F      GE+  ++ P+ FF I+ +F     +  K+EN+ +   R K+
Sbjct: 948  EAKDLFTKAVKHF------GEEAGKIQPDEFFGIFDQFLQAVSEA-KQENENM---RKKK 997

Query: 1691 AEEVCRQKKGKSLYKIKPRHDSGIKAK 1717
             EE  R +    L + + R     KAK
Sbjct: 998  EEEERRARMEAQLKEQRERERKMRKAK 1024



 Score = 71.6 bits (174), Expect = 6e-12
 Identities = 43/92 (46%), Positives = 47/92 (51%), Gaps = 15/92 (16%)

Query: 955  PPPPLPGA-GIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1012
            P  P PGA G P P  +PG+ +PP         PPPPPLPG  + PPPPPLP  G PPPP
Sbjct: 528  PGGPSPGAPGGPFPSSVPGSLLPP---------PPPPPLPGGMLPPPPPPLPPGGPPPPP 578

Query: 1013 PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1044
              P  G   PPP    G P    L    IP P
Sbjct: 579  GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606



 Score = 71.2 bits (173), Expect = 8e-12
 Identities = 43/93 (46%), Positives = 48/93 (51%), Gaps = 15/93 (16%)

Query: 932  LPLPPLPGA-GIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGI-PPPPPLPGAGIPPP 989
            +P  P PGA G P P  +PG+ +PPPPP         PPLPG  + PPPPPLP  G PPP
Sbjct: 527  IPGGPSPGAPGGPFPSSVPGSLLPPPPP---------PPLPGGMLPPPPPPLPPGGPPPP 577

Query: 990  PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1022
            P  P  G   PPP    G P    L    IP P
Sbjct: 578  PGPPPLGAIMPPP----GAPMGLALKKKSIPQP 606



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 43/92 (46%), Positives = 48/92 (52%), Gaps = 15/92 (16%)

Query: 1120 PPPPLPGA-GIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1177
            P  P PGA G P P  +PG+ +PPPPP         PPLPG  + PPPPPLP  G PPPP
Sbjct: 528  PGGPSPGAPGGPFPSSVPGSLLPPPPP---------PPLPGGMLPPPPPPLPPGGPPPPP 578

Query: 1178 PLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPP 1209
              P +G   PPP    G P    L    IP P
Sbjct: 579  GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 46/102 (45%), Positives = 52/102 (50%), Gaps = 24/102 (23%)

Query: 1054 PPPPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPP 1112
            P  P PGA G P P  +PG+ +PP         PPPPPLPG  +PPPPP    G PPPP 
Sbjct: 528  PGGPSPGAPGGPFPSSVPGSLLPP---------PPPPPLPGGMLPPPPPPLPPGGPPPP- 577

Query: 1113 LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPP 1154
                  P PPPL GA +PPP      G P    L +  IP P
Sbjct: 578  ------PGPPPL-GAIMPPP------GAPMGLALKKKSIPQP 606



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 43/92 (46%), Positives = 47/92 (51%), Gaps = 15/92 (16%)

Query: 988  PPPPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1045
            P  P PGA G P P  +PG+ +PP         PPPPPLPG  + PPPPPLP  G PPPP
Sbjct: 528  PGGPSPGAPGGPFPSSVPGSLLPP---------PPPPPLPGGMLPPPPPPLPPGGPPPPP 578

Query: 1046 PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1077
              P  G   PPP    G P    L    IP P
Sbjct: 579  GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 43/92 (46%), Positives = 47/92 (51%), Gaps = 15/92 (16%)

Query: 999  PPPPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1056
            P  P PGA G P P  +PG+ +PPPPP         PPLPG  + PPPPPLP  G PPPP
Sbjct: 528  PGGPSPGAPGGPFPSSVPGSLLPPPPP---------PPLPGGMLPPPPPPLPPGGPPPPP 578

Query: 1057 PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1088
              P  G   PPP    G P    L    IP P
Sbjct: 579  GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 43/92 (46%), Positives = 47/92 (51%), Gaps = 15/92 (16%)

Query: 1032 PPPPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1089
            P  P PGA G P P  +PG+ +PPPPP         PPLPG  + PPPPPLP  G PPPP
Sbjct: 528  PGGPSPGAPGGPFPSSVPGSLLPPPPP---------PPLPGGMLPPPPPPLPPGGPPPPP 578

Query: 1090 PLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPP 1121
              P  G   PPP    G P    L    IP P
Sbjct: 579  GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 43/92 (46%), Positives = 47/92 (51%), Gaps = 15/92 (16%)

Query: 1076 PPPPLPGA-GIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1133
            P  P PGA G P P  +PG+ +PPPPP         PPLPG  + PPPPPLP  G PPPP
Sbjct: 528  PGGPSPGAPGGPFPSSVPGSLLPPPPP---------PPLPGGMLPPPPPPLPPGGPPPPP 578

Query: 1134 PLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPP 1165
              P  G   PPP    G P    L    IP P
Sbjct: 579  GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 43/92 (46%), Positives = 47/92 (51%), Gaps = 15/92 (16%)

Query: 1021 PPPPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAGIPPPP 1078
            P  P PGA G P P  +PG+ +PP         PPPPPLPG  + PPPPPLP  G PPPP
Sbjct: 528  PGGPSPGAPGGPFPSSVPGSLLPP---------PPPPPLPGGMLPPPPPPLPPGGPPPPP 578

Query: 1079 PLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPP 1110
              P  G   PPP    G P    L    IP P
Sbjct: 579  GPPPLGAIMPPP----GAPMGLALKKKSIPQP 606



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 42/97 (43%), Positives = 47/97 (48%), Gaps = 18/97 (18%)

Query: 883 LPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGI 942
           +PG   P  P    P   P  G+ + PPPPPPLPG  +PPPPP          PLP  G 
Sbjct: 527 IPGGPSPGAPGGPFPSSVP--GSLLPPPPPPPLPGGMLPPPPP----------PLPPGGP 574

Query: 943 PPPP-PLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPP 978
           PPPP P P  AI PPP     G P+   L    IP P
Sbjct: 575 PPPPGPPPLGAIMPPP-----GAPMGLALKKKSIPQP 606



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 42/89 (47%), Positives = 46/89 (51%), Gaps = 15/89 (16%)

Query: 969  PLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI-PPPPPLPGAGIPPPPPLP 1026
            P PGA G P P  +PG+ +PPPPP         PPLPG  + PPPPPLP  G PPPP  P
Sbjct: 531  PSPGAPGGPFPSSVPGSLLPPPPP---------PPLPGGMLPPPPPPLPPGGPPPPPGPP 581

Query: 1027 GAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1055
              G   PPP    G P    L    IP P
Sbjct: 582  PLGAIMPPP----GAPMGLALKKKSIPQP 606



 Score = 67.8 bits (164), Expect = 9e-11
 Identities = 45/105 (42%), Positives = 50/105 (47%), Gaps = 23/105 (21%)

Query: 1094 AGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPP 1153
            A IP  P     G P P  +PG+ +PP         PPPPPLPG  +PPPPP    G PP
Sbjct: 525  ASIPGGPSPGAPGGPFPSSVPGSLLPP---------PPPPPLPGGMLPPPPPPLPPGGPP 575

Query: 1154 PPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPP 1198
            PP       P PPPL GA +PPP      G P    L    IP P
Sbjct: 576  PP-------PGPPPL-GAIMPPP------GAPMGLALKKKSIPQP 606



 Score = 65.1 bits (157), Expect = 6e-10
 Identities = 40/98 (40%), Positives = 44/98 (44%), Gaps = 24/98 (24%)

Query: 859 PPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGA 918
           P  P     SS+PG  + PPPPPPLPG                     MLPPPPPPLP  
Sbjct: 533 PGAPGGPFPSSVPGSLLPPPPPPPLPG--------------------GMLPPPPPPLPPG 572

Query: 919 GIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPP 956
           G PPPP  P  G +  PP    G P    L   +IP P
Sbjct: 573 GPPPPPGPPPLGAIMPPP----GAPMGLALKKKSIPQP 606



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 27/61 (44%), Positives = 33/61 (54%), Gaps = 15/61 (24%)

Query: 855 IPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPP 914
           +P PPP P       +PG GM+PPPPPPLP    P  P      PPPL    ++PPP  P
Sbjct: 549 LPPPPPPP-------LPG-GMLPPPPPPLPPGGPPPPPG-----PPPLGA--IMPPPGAP 593

Query: 915 L 915
           +
Sbjct: 594 M 594



 Score = 35.0 bits (79), Expect = 0.63
 Identities = 53/231 (22%), Positives = 80/231 (34%), Gaps = 76/231 (32%)

Query: 676 IQQLEQTIEDLRTKIAELERQYPALDTEVASGHQGLENGVTASGDVCLEALRLEEKEVRH 735
           ++Q ++  E +R +  EL+++    + E  +  Q  E  +     +     +LE++   H
Sbjct: 445 VKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKM---KEKLEKETTEH 501

Query: 736 HRILEAKSIQTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRIS 795
            ++ +  +  T+   E  +        +PG P   PGA  GP   F S +          
Sbjct: 502 KQVKQQVADLTAQLHE--LSRRAVCASIPGGPS--PGAPGGP---FPSSVP--------- 545

Query: 796 VQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNI 855
                     S+  PPPPP L        PG   P                         
Sbjct: 546 ---------GSLLPPPPPPPL--------PGGMLP------------------------- 563

Query: 856 PSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVP-------TLPSTAIPQP 899
           P PPPLP        PG    PP PPPL  +  P        L   +IPQP
Sbjct: 564 PPPPPLP--------PGGPPPPPGPPPLGAIMPPPGAPMGLALKKKSIPQP 606


>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
          Length = 849

 Score =  177 bits (448), Expect = 1e-43
 Identities = 147/541 (27%), Positives = 245/541 (45%), Gaps = 67/541 (12%)

Query: 1195 IPPPPPLPG----AGIPPPPPLP-GMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQV 1249
            IP PP   G    + +PPPPPLP G G+PP P PP PPP  G+     +P SGP      
Sbjct: 297  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMR----MPFSGP------ 346

Query: 1250 GSSTLPTPQVCGFL----PPPLPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRIQLHS 1305
                +P P   GFL     PPLP   FGL         K+  +P   M+ L W +I+ H 
Sbjct: 347  ----VPPPPPLGFLGGQNSPPLPILPFGL-------KPKKEFKPEISMRRLNWLKIRPH- 394

Query: 1306 KRDSSTSLIWEKIEEPSID-----CHEFEELFSKTAVKERKKPISDTISKTKAKQVVKLL 1360
              + + +  W K+ E   +     C        +   +  ++ I +  S  K  + +K L
Sbjct: 395  --EMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFL 452

Query: 1361 SNKRSQAVGILMSSLHLDMKDIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIEKHGR 1420
             +K +Q + I +SS  +  ++I+  ++ +D + +    +Q L ++    ++L  +     
Sbjct: 453  DSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSL----- 507

Query: 1421 SSKDKENAKSLDKPEQFLYELSLIPNFSERVFCILFQSTFSESICSIRRKLELLQKLCET 1480
             S+ K    +L +PEQF+  +S +     R+  ILF+  F E + +I+  +  +   CE 
Sbjct: 508  -SQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEE 566

Query: 1481 LKNGPGVMQVLGLVLAFGNYMNGGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLSYIVS 1540
            +K      ++L LVL  GNYMN G++   Q  GF L  L KLKD KS+D   +LL ++V 
Sbjct: 567  IKKSKSFSKLLELVLLMGNYMNAGSR-NAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVE 625

Query: 1541 YYLRNFDEDAGKEQCLFPLPEPQDLFQASQMKFEDFQKDLRKLKKDLKACEVEAGKVYQV 1600
                 + +       L PL       +AS++  E  +K+LR++ + L+  E E  + +  
Sbjct: 626  ICEEKYPDILNFVDDLEPLD------KASKVSVETLEKNLRQMGRQLQQLEKEL-ETFPP 678

Query: 1601 SSKEHMQPFKENMEQFIIQAKIDQEAEENSLTETHKCFLETTAYFFMKPKLGEKEVSPNA 1660
                H   F   M +F+I AK   E          K +     Y+     +  K+VS   
Sbjct: 679  PEDLH-DKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYY----AIDVKKVSVED 733

Query: 1661 FFSIWHEFSSDF----------KDFWKKENKLLLQERVKEAEEVCRQKKGKSLYKIKPRH 1710
            F +  + F + F          ++  +KE ++ + + + E E + RQ+K K L ++K   
Sbjct: 734  FLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEG 793

Query: 1711 D 1711
            D
Sbjct: 794  D 794



 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 41/79 (51%), Positives = 46/79 (58%), Gaps = 15/79 (18%)

Query: 964  IPLPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1018
            IPLPP   G    + +PPPPPLP G G+PPPPP      PPPPPLPG  +P   P     
Sbjct: 297  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 346

Query: 1019 IPPPPPLPGAGIPPPPPLP 1037
            +PPPPPL   G    PPLP
Sbjct: 347  VPPPPPLGFLGGQNSPPLP 365



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 40/79 (50%), Positives = 46/79 (58%), Gaps = 15/79 (18%)

Query: 1063 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAG 1117
            IP PP   G    + +PPPPPLP G G+PPPPP      PPPPPLPG+ +P   P     
Sbjct: 297  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 346

Query: 1118 IPPPPPLPGAGIPPPPPLP 1136
            +PPPPPL   G    PPLP
Sbjct: 347  VPPPPPLGFLGGQNSPPLP 365



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 40/79 (50%), Positives = 45/79 (56%), Gaps = 15/79 (18%)

Query: 997  IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1051
            IP PP   G    + +PPPPPLP G G+PPPPP      PPPPPLPG  +P   P     
Sbjct: 297  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 346

Query: 1052 IPPPPPLPGAGIPPPPPLP 1070
            +PPPPPL   G    PPLP
Sbjct: 347  VPPPPPLGFLGGQNSPPLP 365



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 40/79 (50%), Positives = 45/79 (56%), Gaps = 15/79 (18%)

Query: 1030 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1084
            IP PP   G    + +PPPPPLP G G+PPPPP      PPPPPLPG  +P   P     
Sbjct: 297  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 346

Query: 1085 IPPPPPLPGAGIPPPPPLP 1103
            +PPPPPL   G    PPLP
Sbjct: 347  VPPPPPLGFLGGQNSPPLP 365



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 40/79 (50%), Positives = 45/79 (56%), Gaps = 15/79 (18%)

Query: 1074 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAG 1128
            IP PP   G    + +PPPPPLP G G+PPPPP      PPPPPLPG  +P   P     
Sbjct: 297  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 346

Query: 1129 IPPPPPLPGAGIPPPPPLP 1147
            +PPPPPL   G    PPLP
Sbjct: 347  VPPPPPLGFLGGQNSPPLP 365



 Score = 71.6 bits (174), Expect = 6e-12
 Identities = 40/79 (50%), Positives = 44/79 (55%), Gaps = 15/79 (18%)

Query: 1096 IPPPPPLPG----VGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVG 1150
            IP PP   G      +PPPPPLP G G+PPPPP      PPPPPLPG  +P   P     
Sbjct: 297  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 346

Query: 1151 IPPPPPLPGAGIPPPPPLP 1169
            +PPPPPL   G    PPLP
Sbjct: 347  VPPPPPLGFLGGQNSPPLP 365



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 40/79 (50%), Positives = 45/79 (56%), Gaps = 15/79 (18%)

Query: 942  IPPPPPLPG----AAIPPPPPLP-GAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 996
            IP PP   G    +A+PPPPPLP G G+P PPP      PPPPPLPG  +P   P     
Sbjct: 297  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 346

Query: 997  IPPPPPLPGAGIPPPPPLP 1015
            +PPPPPL   G    PPLP
Sbjct: 347  VPPPPPLGFLGGQNSPPLP 365



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 38/79 (48%), Positives = 42/79 (53%), Gaps = 13/79 (16%)

Query: 896 IPQPPPLQGT---EMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAA 952
           IP PP  +G      LPPPPP   G G+PPPPP P     P PPLPG  +P   P     
Sbjct: 297 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPP-----PPPPLPGMRMPFSGP----- 346

Query: 953 IPPPPPLPGAGIPLPPPLP 971
           +PPPPPL   G    PPLP
Sbjct: 347 VPPPPPLGFLGGQNSPPLP 365



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 38/79 (48%), Positives = 44/79 (55%), Gaps = 15/79 (18%)

Query: 1041 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1095
            IP PP   G    + +PPPPPLP G G+PPPPP       PPPP P  G+  P   P   
Sbjct: 297  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 346

Query: 1096 IPPPPPLPGVGIPPPPPLP 1114
            +PPPPPL  +G    PPLP
Sbjct: 347  VPPPPPLGFLGGQNSPPLP 365



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)

Query: 1107 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAG 1161
            IP PP   G    + +PPPPPLP G G+PPPPP       PPPP P  G+  P   P   
Sbjct: 297  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 346

Query: 1162 IPPPPPLPGAGIPPPPPLP 1180
            +PPPPPL   G    PPLP
Sbjct: 347  VPPPPPLGFLGGQNSPPLP 365



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)

Query: 975  IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1029
            IP PP   G    + +PPPPPLP G G+PPPPP       PPPP P  G+  P   P   
Sbjct: 297  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 346

Query: 1030 IPPPPPLPGAGIPPPPPLP 1048
            +PPPPPL   G    PPLP
Sbjct: 347  VPPPPPLGFLGGQNSPPLP 365



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)

Query: 986  IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1040
            IP PP   G    + +PPPPPLP G G+PPPPP       PPPP P  G+  P   P   
Sbjct: 297  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 346

Query: 1041 IPPPPPLPGAGIPPPPPLP 1059
            +PPPPPL   G    PPLP
Sbjct: 347  VPPPPPLGFLGGQNSPPLP 365



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)

Query: 1008 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1062
            IP PP   G    + +PPPPPLP G G+PPPPP       PPPP P  G+  P   P   
Sbjct: 297  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 346

Query: 1063 IPPPPPLPGAGIPPPPPLP 1081
            +PPPPPL   G    PPLP
Sbjct: 347  VPPPPPLGFLGGQNSPPLP 365



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)

Query: 1019 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1073
            IP PP   G    + +PPPPPLP G G+PPPPP       PPPP P  G+  P   P   
Sbjct: 297  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 346

Query: 1074 IPPPPPLPGAGIPPPPPLP 1092
            +PPPPPL   G    PPLP
Sbjct: 347  VPPPPPLGFLGGQNSPPLP 365



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)

Query: 1052 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVG 1106
            IP PP   G    + +PPPPPLP G G+PPPPP       PPPP P  G+  P   P   
Sbjct: 297  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 346

Query: 1107 IPPPPPLPGAGIPPPPPLP 1125
            +PPPPPL   G    PPLP
Sbjct: 347  VPPPPPLGFLGGQNSPPLP 365



 Score = 65.1 bits (157), Expect = 6e-10
 Identities = 38/79 (48%), Positives = 44/79 (55%), Gaps = 15/79 (18%)

Query: 1085 IPPPPPLPG----AGIPPPPPLP-GVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1139
            IP PP   G    + +PPPPPLP G G+PPPPP       PPPP P  G+  P   P   
Sbjct: 297  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 346

Query: 1140 IPPPPPLPRVGIPPPPPLP 1158
            +PPPPPL  +G    PPLP
Sbjct: 347  VPPPPPLGFLGGQNSPPLP 365



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 38/89 (42%), Positives = 44/89 (49%), Gaps = 23/89 (25%)

Query: 908 LPPPPPPLPGAG---IPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGI 964
           +P PP    G G   +PPPPPLP  G          G+PPPPP       PPPP P  G+
Sbjct: 297 IPLPPSKEGGTGHSALPPPPPLPSGG----------GVPPPPP-------PPPPPPLPGM 339

Query: 965 PLPPPLPGAGIPPPPPLPGAGIPPPPPLP 993
            +P   P   +PPPPPL   G    PPLP
Sbjct: 340 RMPFSGP---VPPPPPLGFLGGQNSPPLP 365



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 41/98 (41%), Positives = 44/98 (44%), Gaps = 29/98 (29%)

Query: 848 AFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPS-TAIPQPPPLQGTE 906
           A    CNIP PP      S     G   +PPPPP         LPS   +P PPP     
Sbjct: 290 ALPADCNIPLPP------SKEGGTGHSALPPPPP---------LPSGGGVPPPPP----- 329

Query: 907 MLPPPPPPLPG------AGIPPPPPLPGAGILPLPPLP 938
             PPPPPPLPG        +PPPPPL   G    PPLP
Sbjct: 330 --PPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLP 365



 Score = 61.2 bits (147), Expect = 8e-09
 Identities = 38/85 (44%), Positives = 43/85 (50%), Gaps = 16/85 (18%)

Query: 926  LPGAGILPLPPLPGAG-----IPPPPPLP-GAAIPPPPPLPGAGIPLPPPLPGAGIPPPP 979
            LP    +PLPP    G     +PPPPPLP G  +PPPPP P       PP P  G+  P 
Sbjct: 291  LPADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPP-------PPPPLPGMRMPF 343

Query: 980  PLPGAGIPPPPPLPGAGIPPPPPLP 1004
              P   +PPPPPL   G    PPLP
Sbjct: 344  SGP---VPPPPPLGFLGGQNSPPLP 365



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 29/68 (42%), Positives = 34/68 (50%), Gaps = 6/68 (8%)

Query: 855 IPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPP 914
           +P PPPLP        P     PPPPPPLPGM +P   S  +P PPPL        PP P
Sbjct: 312 LPPPPPLPSGGGVPPPPP----PPPPPPLPGMRMPF--SGPVPPPPPLGFLGGQNSPPLP 365

Query: 915 LPGAGIPP 922
           +   G+ P
Sbjct: 366 ILPFGLKP 373


>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
          Length = 1193

 Score =  177 bits (448), Expect = 1e-43
 Identities = 147/541 (27%), Positives = 245/541 (45%), Gaps = 67/541 (12%)

Query: 1195 IPPPPPLPG----AGIPPPPPLP-GMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQV 1249
            IP PP   G    + +PPPPPLP G G+PP P PP PPP  G+     +P SGP      
Sbjct: 560  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMR----MPFSGP------ 609

Query: 1250 GSSTLPTPQVCGFL----PPPLPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRIQLHS 1305
                +P P   GFL     PPLP   FGL         K+  +P   M+ L W +I+ H 
Sbjct: 610  ----VPPPPPLGFLGGQNSPPLPILPFGL-------KPKKEFKPEISMRRLNWLKIRPH- 657

Query: 1306 KRDSSTSLIWEKIEEPSID-----CHEFEELFSKTAVKERKKPISDTISKTKAKQVVKLL 1360
              + + +  W K+ E   +     C        +   +  ++ I +  S  K  + +K L
Sbjct: 658  --EMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFL 715

Query: 1361 SNKRSQAVGILMSSLHLDMKDIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIEKHGR 1420
             +K +Q + I +SS  +  ++I+  ++ +D + +    +Q L ++    ++L  +     
Sbjct: 716  DSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSL----- 770

Query: 1421 SSKDKENAKSLDKPEQFLYELSLIPNFSERVFCILFQSTFSESICSIRRKLELLQKLCET 1480
             S+ K    +L +PEQF+  +S +     R+  ILF+  F E + +I+  +  +   CE 
Sbjct: 771  -SQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEE 829

Query: 1481 LKNGPGVMQVLGLVLAFGNYMNGGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLSYIVS 1540
            +K      ++L LVL  GNYMN G++   Q  GF L  L KLKD KS+D   +LL ++V 
Sbjct: 830  IKKSKSFSKLLELVLLMGNYMNAGSR-NAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVE 888

Query: 1541 YYLRNFDEDAGKEQCLFPLPEPQDLFQASQMKFEDFQKDLRKLKKDLKACEVEAGKVYQV 1600
                 + +       L PL       +AS++  E  +K+LR++ + L+  E E  + +  
Sbjct: 889  ICEEKYPDILNFVDDLEPLD------KASKVSVETLEKNLRQMGRQLQQLEKEL-ETFPP 941

Query: 1601 SSKEHMQPFKENMEQFIIQAKIDQEAEENSLTETHKCFLETTAYFFMKPKLGEKEVSPNA 1660
                H   F   M +F+I AK   E          K +     Y+     +  K+VS   
Sbjct: 942  PEDLH-DKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYY----AIDVKKVSVED 996

Query: 1661 FFSIWHEFSSDF----------KDFWKKENKLLLQERVKEAEEVCRQKKGKSLYKIKPRH 1710
            F +  + F + F          ++  +KE ++ + + + E E + RQ+K K L ++K   
Sbjct: 997  FLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEG 1056

Query: 1711 D 1711
            D
Sbjct: 1057 D 1057



 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 41/79 (51%), Positives = 46/79 (58%), Gaps = 15/79 (18%)

Query: 964  IPLPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1018
            IPLPP   G    + +PPPPPLP G G+PPPPP      PPPPPLPG  +P   P     
Sbjct: 560  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 609

Query: 1019 IPPPPPLPGAGIPPPPPLP 1037
            +PPPPPL   G    PPLP
Sbjct: 610  VPPPPPLGFLGGQNSPPLP 628



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 40/79 (50%), Positives = 46/79 (58%), Gaps = 15/79 (18%)

Query: 1063 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAG 1117
            IP PP   G    + +PPPPPLP G G+PPPPP      PPPPPLPG+ +P   P     
Sbjct: 560  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 609

Query: 1118 IPPPPPLPGAGIPPPPPLP 1136
            +PPPPPL   G    PPLP
Sbjct: 610  VPPPPPLGFLGGQNSPPLP 628



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 40/79 (50%), Positives = 45/79 (56%), Gaps = 15/79 (18%)

Query: 997  IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1051
            IP PP   G    + +PPPPPLP G G+PPPPP      PPPPPLPG  +P   P     
Sbjct: 560  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 609

Query: 1052 IPPPPPLPGAGIPPPPPLP 1070
            +PPPPPL   G    PPLP
Sbjct: 610  VPPPPPLGFLGGQNSPPLP 628



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 40/79 (50%), Positives = 45/79 (56%), Gaps = 15/79 (18%)

Query: 1030 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1084
            IP PP   G    + +PPPPPLP G G+PPPPP      PPPPPLPG  +P   P     
Sbjct: 560  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 609

Query: 1085 IPPPPPLPGAGIPPPPPLP 1103
            +PPPPPL   G    PPLP
Sbjct: 610  VPPPPPLGFLGGQNSPPLP 628



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 40/79 (50%), Positives = 45/79 (56%), Gaps = 15/79 (18%)

Query: 1074 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAG 1128
            IP PP   G    + +PPPPPLP G G+PPPPP      PPPPPLPG  +P   P     
Sbjct: 560  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 609

Query: 1129 IPPPPPLPGAGIPPPPPLP 1147
            +PPPPPL   G    PPLP
Sbjct: 610  VPPPPPLGFLGGQNSPPLP 628



 Score = 71.6 bits (174), Expect = 6e-12
 Identities = 40/79 (50%), Positives = 44/79 (55%), Gaps = 15/79 (18%)

Query: 1096 IPPPPPLPG----VGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVG 1150
            IP PP   G      +PPPPPLP G G+PPPPP      PPPPPLPG  +P   P     
Sbjct: 560  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 609

Query: 1151 IPPPPPLPGAGIPPPPPLP 1169
            +PPPPPL   G    PPLP
Sbjct: 610  VPPPPPLGFLGGQNSPPLP 628



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 40/79 (50%), Positives = 45/79 (56%), Gaps = 15/79 (18%)

Query: 942  IPPPPPLPG----AAIPPPPPLP-GAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 996
            IP PP   G    +A+PPPPPLP G G+P PPP      PPPPPLPG  +P   P     
Sbjct: 560  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 609

Query: 997  IPPPPPLPGAGIPPPPPLP 1015
            +PPPPPL   G    PPLP
Sbjct: 610  VPPPPPLGFLGGQNSPPLP 628



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 38/79 (48%), Positives = 42/79 (53%), Gaps = 13/79 (16%)

Query: 896 IPQPPPLQGT---EMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAA 952
           IP PP  +G      LPPPPP   G G+PPPPP P     P PPLPG  +P   P     
Sbjct: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPP-----PPPPLPGMRMPFSGP----- 609

Query: 953 IPPPPPLPGAGIPLPPPLP 971
           +PPPPPL   G    PPLP
Sbjct: 610 VPPPPPLGFLGGQNSPPLP 628



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 38/79 (48%), Positives = 44/79 (55%), Gaps = 15/79 (18%)

Query: 1041 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1095
            IP PP   G    + +PPPPPLP G G+PPPPP       PPPP P  G+  P   P   
Sbjct: 560  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 609

Query: 1096 IPPPPPLPGVGIPPPPPLP 1114
            +PPPPPL  +G    PPLP
Sbjct: 610  VPPPPPLGFLGGQNSPPLP 628



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)

Query: 1107 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAG 1161
            IP PP   G    + +PPPPPLP G G+PPPPP       PPPP P  G+  P   P   
Sbjct: 560  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 609

Query: 1162 IPPPPPLPGAGIPPPPPLP 1180
            +PPPPPL   G    PPLP
Sbjct: 610  VPPPPPLGFLGGQNSPPLP 628



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)

Query: 975  IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1029
            IP PP   G    + +PPPPPLP G G+PPPPP       PPPP P  G+  P   P   
Sbjct: 560  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 609

Query: 1030 IPPPPPLPGAGIPPPPPLP 1048
            +PPPPPL   G    PPLP
Sbjct: 610  VPPPPPLGFLGGQNSPPLP 628



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)

Query: 986  IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1040
            IP PP   G    + +PPPPPLP G G+PPPPP       PPPP P  G+  P   P   
Sbjct: 560  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 609

Query: 1041 IPPPPPLPGAGIPPPPPLP 1059
            +PPPPPL   G    PPLP
Sbjct: 610  VPPPPPLGFLGGQNSPPLP 628



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)

Query: 1008 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1062
            IP PP   G    + +PPPPPLP G G+PPPPP       PPPP P  G+  P   P   
Sbjct: 560  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 609

Query: 1063 IPPPPPLPGAGIPPPPPLP 1081
            +PPPPPL   G    PPLP
Sbjct: 610  VPPPPPLGFLGGQNSPPLP 628



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)

Query: 1019 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1073
            IP PP   G    + +PPPPPLP G G+PPPPP       PPPP P  G+  P   P   
Sbjct: 560  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 609

Query: 1074 IPPPPPLPGAGIPPPPPLP 1092
            +PPPPPL   G    PPLP
Sbjct: 610  VPPPPPLGFLGGQNSPPLP 628



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)

Query: 1052 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVG 1106
            IP PP   G    + +PPPPPLP G G+PPPPP       PPPP P  G+  P   P   
Sbjct: 560  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 609

Query: 1107 IPPPPPLPGAGIPPPPPLP 1125
            +PPPPPL   G    PPLP
Sbjct: 610  VPPPPPLGFLGGQNSPPLP 628



 Score = 65.1 bits (157), Expect = 6e-10
 Identities = 38/79 (48%), Positives = 44/79 (55%), Gaps = 15/79 (18%)

Query: 1085 IPPPPPLPG----AGIPPPPPLP-GVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1139
            IP PP   G    + +PPPPPLP G G+PPPPP       PPPP P  G+  P   P   
Sbjct: 560  IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 609

Query: 1140 IPPPPPLPRVGIPPPPPLP 1158
            +PPPPPL  +G    PPLP
Sbjct: 610  VPPPPPLGFLGGQNSPPLP 628



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 38/89 (42%), Positives = 44/89 (49%), Gaps = 23/89 (25%)

Query: 908 LPPPPPPLPGAG---IPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGI 964
           +P PP    G G   +PPPPPLP  G          G+PPPPP       PPPP P  G+
Sbjct: 560 IPLPPSKEGGTGHSALPPPPPLPSGG----------GVPPPPP-------PPPPPPLPGM 602

Query: 965 PLPPPLPGAGIPPPPPLPGAGIPPPPPLP 993
            +P   P   +PPPPPL   G    PPLP
Sbjct: 603 RMPFSGP---VPPPPPLGFLGGQNSPPLP 628



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 41/98 (41%), Positives = 44/98 (44%), Gaps = 29/98 (29%)

Query: 848 AFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPS-TAIPQPPPLQGTE 906
           A    CNIP PP      S     G   +PPPPP         LPS   +P PPP     
Sbjct: 553 ALPADCNIPLPP------SKEGGTGHSALPPPPP---------LPSGGGVPPPPP----- 592

Query: 907 MLPPPPPPLPG------AGIPPPPPLPGAGILPLPPLP 938
             PPPPPPLPG        +PPPPPL   G    PPLP
Sbjct: 593 --PPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLP 628



 Score = 61.2 bits (147), Expect = 8e-09
 Identities = 38/85 (44%), Positives = 43/85 (50%), Gaps = 16/85 (18%)

Query: 926  LPGAGILPLPPLPGAG-----IPPPPPLP-GAAIPPPPPLPGAGIPLPPPLPGAGIPPPP 979
            LP    +PLPP    G     +PPPPPLP G  +PPPPP P       PP P  G+  P 
Sbjct: 554  LPADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPP-------PPPPLPGMRMPF 606

Query: 980  PLPGAGIPPPPPLPGAGIPPPPPLP 1004
              P   +PPPPPL   G    PPLP
Sbjct: 607  SGP---VPPPPPLGFLGGQNSPPLP 628



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 29/68 (42%), Positives = 34/68 (50%), Gaps = 6/68 (8%)

Query: 855 IPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPP 914
           +P PPPLP        P     PPPPPPLPGM +P   S  +P PPPL        PP P
Sbjct: 575 LPPPPPLPSGGGVPPPPP----PPPPPPLPGMRMPF--SGPVPPPPPLGFLGGQNSPPLP 628

Query: 915 LPGAGIPP 922
           +   G+ P
Sbjct: 629 ILPFGLKP 636


>gi|15890086 type IV collagen alpha 5 isoform 2 precursor [Homo
            sapiens]
          Length = 1691

 Score =  168 bits (425), Expect = 5e-41
 Identities = 224/694 (32%), Positives = 260/694 (37%), Gaps = 196/694 (28%)

Query: 750  EEGGVLTLPPVDGLPGRP--------PCPPGAESGPQTKFCSEISLIVSPRRISVQLDSH 801
            + G  +T P   GLPG P        P  PG    P             P     + +  
Sbjct: 654  DPGQTITQPGKPGLPGNPGRDGDVGLPGDPGLPGQPGL-----------PGIPGSKGEPG 702

Query: 802  QPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPP-- 859
             P   +  PP P         G PG  PP +  T  +   E             P PP  
Sbjct: 703  IPGIGLPGPPGPKGF-----PGIPG--PPGAPGTPGRIGLE-----------GPPGPPGF 744

Query: 860  PLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPS-----TAIPQPPPLQGTEMLPPP--- 911
            P P  E   ++PG    PP PP LPG      P         P PP   G + LP P   
Sbjct: 745  PGPKGEPGFALPG----PPGPPGLPGFKGALGPKGDRGFPGPPGPPGRTGLDGLPGPKGD 800

Query: 912  -----------PPPLPGAGI---PPPPPLPG-AGILPLPPLPGAGIPPPPPLPGAAIPPP 956
                       PP LPG G+   P PP +PG  G   L  +PG    P P  PG  +P P
Sbjct: 801  VGPNGQPGPMGPPGLPGIGVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGP--PGLDVPGP 858

Query: 957  ------PPLPGAGIPLPPP----LPG----AGIP----------PPPPLPGAGIPPPPPL 992
                  P +PGA  P+ PP    LPG    +G P          PP P    GIP    +
Sbjct: 859  PGERGSPGIPGAPGPIGPPGSPGLPGKAGASGFPGTKGEMGMMGPPGPPGPLGIPGRSGV 918

Query: 993  PGA----GIPPPPPLPG----AGIPPPPPLPGAGIPPPPPLPGA----GIPPPPPLPGA- 1039
            PG     G+   P LPG     G    P LPG   P  P L G+    G P  P +PG  
Sbjct: 919  PGLKGDDGLQGQPGLPGPTGEKGSKGEPGLPGPPGPMDPNLLGSKGEKGEPGLPGIPGVS 978

Query: 1040 ------GIPPPPPLPG----AGIPPP------PPLPG-AGIPPPPPLPGA----GIP--- 1075
                  G+P  P  PG     G+P P      P LPG  G+  PP L G     G P   
Sbjct: 979  GPKGYQGLPGDPGQPGLSGQPGLPGPPGPKGNPGLPGQPGLIGPPGLKGTIGDMGFPGPQ 1038

Query: 1076 ----PPPPLPGAGIPPPPPLPG---------------AGIPPPPPLPGV-GIPPPPPLPG 1115
                PP P    G P  P LPG                G+P P   PG+ G P  P + G
Sbjct: 1039 GVEGPPGPSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGNPGIKG 1098

Query: 1116 A-GIPPPPPLPGA-GIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIP-PPPPLPGAG 1172
            + G P  P LPG  G    P LPG    P PP P+ GI  PP  P  G+P  P P+ G G
Sbjct: 1099 SVGDPGLPGLPGTPGAKGQPGLPGFPGTPGPPGPK-GISGPPGNP--GLPGEPGPVGGGG 1155

Query: 1173 IPPPPPLPGV-------GIPPP------PPLPGVGIPPPPPLPG----------AGIPPP 1209
             P  P  PG        GIP P      P  PG G P PP LPG           GIP  
Sbjct: 1156 HPGQPGPPGEKGKPGQDGIPGPAGQKGEPGQPGFGNPGPPGLPGLSGQKGDGGLPGIPGN 1215

Query: 1210 PPLPG-------MGIPPAPAPPLPP--PGTGIPPPPLLP-VSGPPLLP-QVGSSTLPTPQ 1258
            P LPG        G P    PP PP  PG  +  P   P   GPP  P   G   LP P+
Sbjct: 1216 PGLPGPKGEPGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQGPPGRPGPTGFQGLPGPE 1275

Query: 1259 VCGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRP 1292
                 PP LP      G+  +KG+  QP  P  P
Sbjct: 1276 G----PPGLPG---NGGIKGEKGNPGQPGLPGLP 1302



 Score =  163 bits (412), Expect = 2e-39
 Identities = 175/492 (35%), Positives = 198/492 (40%), Gaps = 92/492 (18%)

Query: 856  PSPPPLPCTESSSSMPGLGMVPPPPPPLPGMT-VPTLPST-AIPQPPPLQGTEMLPPPPP 913
            P  P LP        PG G  PP P    G+  V   P    IP P    G  +  P  P
Sbjct: 608  PGLPGLPGNIGPMGPPGFG--PPGPVGEKGIQGVAGNPGQPGIPGPKGDPGQTITQPGKP 665

Query: 914  PLPG-------AGIPPPPPLPGAGILP-------LPPLPGAGIPPPPPLPG-AAIPPPPP 958
             LPG        G+P  P LPG   LP        P +PG G+P PP   G   IP PP 
Sbjct: 666  GLPGNPGRDGDVGLPGDPGLPGQPGLPGIPGSKGEPGIPGIGLPGPPGPKGFPGIPGPPG 725

Query: 959  LPGA-------GIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPG----------AGIPPPP 1001
             PG        G P PP  PG    P   LPG   P PP LPG           G P PP
Sbjct: 726  APGTPGRIGLEGPPGPPGFPGPKGEPGFALPGP--PGPPGLPGFKGALGPKGDRGFPGPP 783

Query: 1002 PLPGA----GIPPPPPLPGAGIPP----PPPLPGAGIPPPPPLPGAGIPPPPPLPGA-GI 1052
              PG     G+P P    G    P    PP LPG G+  PP  P  GIP P   PG  GI
Sbjct: 784  GPPGRTGLDGLPGPKGDVGPNGQPGPMGPPGLPGIGVQGPPGPP--GIPGPIGQPGLHGI 841

Query: 1053 P---PPPPLPGAGIPPPPPLPGAGIPPPPPLPG-AGIPPPPPLPG----AGIPPPPPLPG 1104
            P     P  PG  +P PP   G+  P  P  PG  G P  P LPG    +G P      G
Sbjct: 842  PGEKGDPGPPGLDVPGPPGERGS--PGIPGAPGPIGPPGSPGLPGKAGASGFPGTKGEMG 899

Query: 1105 VGIPPPPPLPGAGIPPPPPLPGA----GIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGA 1160
            +  PP PP P  GIP    +PG     G+   P LPG       P    G    P LPG 
Sbjct: 900  MMGPPGPPGP-LGIPGRSGVPGLKGDDGLQGQPGLPG-------PTGEKGSKGEPGLPGP 951

Query: 1161 GIPPPPPLPGA-GIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGM-GIP 1218
              P  P L G+ G    P LPG+        PGV      P    G+P  P  PG+ G P
Sbjct: 952  PGPMDPNLLGSKGEKGEPGLPGI--------PGVS----GPKGYQGLPGDPGQPGLSGQP 999

Query: 1219 PAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGL---- 1274
              P PP P    G+P  P L +  P L   +G    P PQ  G   PP PSG+ G     
Sbjct: 1000 GLPGPPGPKGNPGLPGQPGL-IGPPGLKGTIGDMGFPGPQ--GVEGPPGPSGVPGQPGSP 1056

Query: 1275 GMNQDKGSRKQP 1286
            G+   KG +  P
Sbjct: 1057 GLPGQKGDKGDP 1068



 Score =  155 bits (393), Expect = 2e-37
 Identities = 214/663 (32%), Positives = 248/663 (37%), Gaps = 157/663 (23%)

Query: 759  PVDGLPGRP--------PCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQP 810
            P  GLPG P        P PPGA   P       I L   P          +P  ++  P
Sbjct: 704  PGIGLPGPPGPKGFPGIPGPPGAPGTP-----GRIGLEGPPGPPGFPGPKGEPGFALPGP 758

Query: 811  PPPPSLLWSAG-------QGQPGSQ-PPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLP 862
            P PP L    G       +G PG   PP     +     +  V     N    P  PP  
Sbjct: 759  PGPPGLPGFKGALGPKGDRGFPGPPGPPGRTGLDGLPGPKGDVGP---NGQPGPMGPP-- 813

Query: 863  CTESSSSMPGLGMVPPPPPP-------------LPGMTV-PTLPSTAIPQPPPLQGTEML 908
                   +PG+G+  PP PP             +PG    P  P   +P PP  +G+  +
Sbjct: 814  ------GLPGIGVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGPPGLDVPGPPGERGSPGI 867

Query: 909  PPPPPPLPGAGIPPPPPLPG-AGILPLPPLPGA-GIPPPPPLPGA-AIPPPPPLPGA--- 962
            P  P P+   G P  P LPG AG    P   G  G+  PP  PG   IP    +PG    
Sbjct: 868  PGAPGPI---GPPGSPGLPGKAGASGFPGTKGEMGMMGPPGPPGPLGIPGRSGVPGLKGD 924

Query: 963  -GIPLPPPLPGA----GIPPPPPLPGAGIPPPPPLPGA----GIPPPPPLPGA------- 1006
             G+   P LPG     G    P LPG   P  P L G+    G P  P +PG        
Sbjct: 925  DGLQGQPGLPGPTGEKGSKGEPGLPGPPGPMDPNLLGSKGEKGEPGLPGIPGVSGPKGYQ 984

Query: 1007 GIPPPPPLPGA----GIPPPPP------LPGA-GIPPPPPLPGA----GIPPP-----PP 1046
            G+P  P  PG     G+P PP       LPG  G+  PP L G     G P P     PP
Sbjct: 985  GLPGDPGQPGLSGQPGLPGPPGPKGNPGLPGQPGLIGPPGLKGTIGDMGFPGPQGVEGPP 1044

Query: 1047 LPGA--GIPPPPPLPGA---------------GIPPPPPLPGA-GIPPPPPLPGA----G 1084
             P    G P  P LPG                G+P P   PG  G P  P + G+    G
Sbjct: 1045 GPSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGNPGIKGSVGDPG 1104

Query: 1085 IPPPPPLPGA-GIPPPPPLPGVGIPPPP-----PLPGAGIPPPP-PLPGAGIPPPPPLPG 1137
            +P  P  PGA G P  P  PG   PP P     P    G+P  P P+ G G P  P  PG
Sbjct: 1105 LPGLPGTPGAKGQPGLPGFPGTPGPPGPKGISGPPGNPGLPGEPGPVGGGGHPGQPGPPG 1164

Query: 1138 A-------GIPPP------PPLPRVGIPPPPPLPGA----------GIPPPPPLPGA-GI 1173
                    GIP P      P  P  G P PP LPG           GIP  P LPG  G 
Sbjct: 1165 EKGKPGQDGIPGPAGQKGEPGQPGFGNPGPPGLPGLSGQKGDGGLPGIPGNPGLPGPKGE 1224

Query: 1174 PPPPPLPGVGIPPPPP-LPGVGIPPPPPLPGAGIPP--PPPLPGMGIPPAPAPPLPPPGT 1230
            P     PGV  PP PP  PG  +  P   PG   PP  P P    G+P    PP  P   
Sbjct: 1225 PGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQGPPGRPGPTGFQGLPGPEGPPGLPGNG 1284

Query: 1231 GIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGL-GMNQDKGSRKQPIEP 1289
            GI      P  G P LP +       P + G   PP   G  G  G+N  KG    P  P
Sbjct: 1285 GIKGEKGNP--GQPGLPGL-------PGLKGDQGPPGLQGNPGRPGLNGMKGDPGLPGVP 1335

Query: 1290 CRP 1292
              P
Sbjct: 1336 GFP 1338



 Score =  153 bits (387), Expect = 1e-36
 Identities = 212/642 (33%), Positives = 240/642 (37%), Gaps = 162/642 (25%)

Query: 748  PTEEG--GVLTLPPVDGLPGRPPCP--PGAESGPQTKFCSEISLIVSPRRISVQLDSHQP 803
            P E G  G+   P   G PG P  P   GA   P TK   E+ ++  P            
Sbjct: 859  PGERGSPGIPGAPGPIGPPGSPGLPGKAGASGFPGTK--GEMGMMGPPG----------- 905

Query: 804  TQSISQPPPPPSLLWSAG----------QGQPGSQPPHSISTEFQTSHEHSVSSAFKNSC 853
                  PP P  +   +G          QGQPG   P        T  + S         
Sbjct: 906  ------PPGPLGIPGRSGVPGLKGDDGLQGQPGLPGP--------TGEKGSKGEPGLPGP 951

Query: 854  NIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPT----LPSTAIPQPPPLQGTEMLP 909
              P  P L  ++     PGL       P +PG++ P     LP    P  P L G   LP
Sbjct: 952  PGPMDPNLLGSKGEKGEPGL-------PGIPGVSGPKGYQGLPGD--PGQPGLSGQPGLP 1002

Query: 910  PPPPPLPGAGIPPPPPLPGA-------GILPLPPLPGAGIPPPPP-LPGAAIPPPPPLPG 961
             PP P    G+P  P L G        G +  P   G   PP P  +PG   P  P LPG
Sbjct: 1003 GPPGPKGNPGLPGQPGLIGPPGLKGTIGDMGFPGPQGVEGPPGPSGVPGQ--PGSPGLPG 1060

Query: 962  A------------GIP-LPPPLPGAGIPPPPPLPG----AGIPPPPPLPGA-GIPPPPPL 1003
                         G+P LP P    G+P  P  PG     G P  P LPG  G    P L
Sbjct: 1061 QKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGNPGIKGSVGDPGLPGLPGTPGAKGQPGL 1120

Query: 1004 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP-PLPGAGIPPPPPLPGA-GIPPPPPLPG- 1060
            PG    P PP P  GI  PP  PG  +P  P P+ G G P  P  PG  G P    +PG 
Sbjct: 1121 PGFPGTPGPPGP-KGISGPPGNPG--LPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGP 1177

Query: 1061 AGIPPPPPLPGAGIPPPPPLPGA----------GIPPPPPLPGA-GIPPPPPLPGVGIPP 1109
            AG    P  PG G P PP LPG           GIP  P LPG  G P     PGV  PP
Sbjct: 1178 AGQKGEPGQPGFGNPGPPGLPGLSGQKGDGGLPGIPGNPGLPGPKGEPGFHGFPGVQGPP 1237

Query: 1110 PPP-LPGAGIPPPPPLPGAGIPP--PPPLPGAGIPPP---PPLP-------RVGIPPPPP 1156
             PP  PG  +  P   PG   PP  P P    G+P P   P LP         G P  P 
Sbjct: 1238 GPPGSPGPALEGPKGNPGPQGPPGRPGPTGFQGLPGPEGPPGLPGNGGIKGEKGNPGQPG 1297

Query: 1157 LPGA----GIPPPPPLPGA-------GIPPPPPLPGV----GIPPPPPLPG--------- 1192
            LPG     G   PP L G        G+   P LPGV    G+  P  +PG         
Sbjct: 1298 LPGLPGLKGDQGPPGLQGNPGRPGLNGMKGDPGLPGVPGFPGMKGPSGVPGSAGPEGEPG 1357

Query: 1193 -VGIPPPPPLPG-----------AGIPPPPPLPGMGIPPAPAPPLPPPG-TGIPPPPLLP 1239
             +G P PP LPG           AG P  P  PG+   P P  P   PG TG P  P   
Sbjct: 1358 LIGPPGPPGLPGPSGQSIIIKGDAGPPGIPGQPGLKGLPGPQGPQGLPGPTGPPGDP--- 1414

Query: 1240 VSGPPLLP-------QVGSSTLP-TPQVCGFLPPPLPSGLFG 1273
              G   LP       + G   LP  P   G   PP P GL G
Sbjct: 1415 --GRNGLPGFDGAGGRKGDPGLPGQPGTRGLDGPPGPDGLQG 1454



 Score =  148 bits (373), Expect = 5e-35
 Identities = 195/583 (33%), Positives = 224/583 (38%), Gaps = 95/583 (16%)

Query: 753  GVLTLPPVDGLPGRPPCP-PGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPP 811
            GV  L   DGL G+P  P P  E G +     E  L   P  +   L   +  +     P
Sbjct: 917  GVPGLKGDDGLQGQPGLPGPTGEKGSK----GEPGLPGPPGPMDPNLLGSKGEKGEPGLP 972

Query: 812  PPPSLLWSAG-QGQPGS--QPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSS 868
              P +    G QG PG   QP  S             +        +  PP L  T    
Sbjct: 973  GIPGVSGPKGYQGLPGDPGQPGLSGQPGLPGPPGPKGNPGLPGQPGLIGPPGLKGTIGDM 1032

Query: 869  SMPGLGMVPPPPPP--LPGMT-VPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPP 925
              PG   V  PP P  +PG    P LP     +  P   +  LP  P P    G+P  P 
Sbjct: 1033 GFPGPQGVEGPPGPSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPG 1092

Query: 926  LPG----AGILPLPPLPGA-GIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPP- 979
             PG     G   LP LPG  G    P LPG    P PP P  GI  PP  PG  +P  P 
Sbjct: 1093 NPGIKGSVGDPGLPGLPGTPGAKGQPGLPGFPGTPGPPGP-KGISGPPGNPG--LPGEPG 1149

Query: 980  PLPGAGIPPPPPLPGA-GIPPPPPLPG-AGIPPPPPLPGAGIPPPPPLPGA--------- 1028
            P+ G G P  P  PG  G P    +PG AG    P  PG G P PP LPG          
Sbjct: 1150 PVGGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGEPGQPGFGNPGPPGLPGLSGQKGDGGL 1209

Query: 1029 -GIPPPPPLPGA-GIPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPGAGIPP--PPPLPGA 1083
             GIP  P LPG  G P     PG   PP PP  PG  +  P   PG   PP  P P    
Sbjct: 1210 PGIPGNPGLPGPKGEPGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQGPPGRPGPTGFQ 1269

Query: 1084 GIPPP---PPLPG-------AGIPPPPPLPGV----GIPPPPPLPGA-------GIPPPP 1122
            G+P P   P LPG        G P  P LPG+    G   PP L G        G+   P
Sbjct: 1270 GLPGPEGPPGLPGNGGIKGEKGNPGQPGLPGLPGLKGDQGPPGLQGNPGRPGLNGMKGDP 1329

Query: 1123 PLPGA----GIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGA--------GIPPPPPLPG 1170
             LPG     G+  P  +PG+  P   P   +G P PP LPG         G   PP    
Sbjct: 1330 GLPGVPGFPGMKGPSGVPGSAGPEGEP-GLIGPPGPPGLPGPSGQSIIIKGDAGPP---- 1384

Query: 1171 AGIPPPPPLPGVGIPPPPP-LPGVGIPPPPP----LPG----------AGIPPPPPLPGM 1215
             GIP  P L G+  P  P  LPG   PP  P    LPG           G+P  P   G+
Sbjct: 1385 -GIPGQPGLKGLPGPQGPQGLPGPTGPPGDPGRNGLPGFDGAGGRKGDPGLPGQPGTRGL 1443

Query: 1216 GIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQ 1258
              PP P     PPG    PP    V+   L+ +  S T   PQ
Sbjct: 1444 DGPPGPDGLQGPPG----PPGTSSVAHGFLITR-HSQTTDAPQ 1481



 Score =  139 bits (349), Expect = 3e-32
 Identities = 211/676 (31%), Positives = 240/676 (35%), Gaps = 160/676 (23%)

Query: 751  EGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQP 810
            E G    P ++G PG P  P G E  P  +       I  P             + I  P
Sbjct: 46   EKGERGFPGLEGHPGLPGFP-GPEGPPGPRGQKGDDGIPGP----------PGPKGIRGP 94

Query: 811  PPPPSLLWSAG----QGQPGSQPPHSISTEFQTSHEHSV--SSAFKNSCNIPSPPPLPCT 864
            P  P    + G     G  G+  P  I     T  E     S  F      P PP +P  
Sbjct: 95   PGLPGFPGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGM 154

Query: 865  ESS------SSMPGLGMVP--PPPPPLPGMTVPT-LPST-AIPQPPPLQGTEMLPPPPPP 914
            +        SS+PG    P  P PP + G+  PT +P     P PP L G    PP PP 
Sbjct: 155  KGEPGSIIMSSLPGPKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMG----PPGPPG 210

Query: 915  LPGA------------------GIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPP 956
            LPG                   G+  PP  PG       P+          LPG   PP 
Sbjct: 211  LPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQKGDQGLPGDRGPPG 270

Query: 957  PPLPGAGIPLPPPLPGA--------GIPPPPPLPGA----GIPPPPPLPG-AGIPPPPPL 1003
            PP    GI  PP  PG         G P     PG     G P  P LPG  G P  P  
Sbjct: 271  PP----GIRGPPGPPGGEKGEKGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGR 326

Query: 1004 PGA----GIPPPPPLPGAGIPPP--------------PPLPGA-------GIPPPPPLPG 1038
             G     G   PP  PG  IP P              P LPG        GI  PP LPG
Sbjct: 327  DGEKGQKGDTGPPGPPGLVIPRPGTGITIGEKGNIGLPGLPGEKGERGFPGIQGPPGLPG 386

Query: 1039 AGIPPPPPLPGAGIPPPPPLPGA-GIPPPPPLPGAGIPPPPPL---PGA-GIPPPPPLPG 1093
                 PP     G P PP  PG  G       PG  IP PP L   PGA G+P PP   G
Sbjct: 387  -----PPGAAVMGPPGPPGFPGERGQKGDEGPPGISIPGPPGLDGQPGAPGLPGPPGPAG 441

Query: 1094 AGIPPPPPLPGVGIPPPPPLPG-----------------------AGIPPPPPLPGA-GI 1129
              IPP   +   G P PP  PG                        GI  PP  PG  G+
Sbjct: 442  PHIPPSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPGQPGLPGL 501

Query: 1130 PPPPP---LPG-------AGIPPPPPLPRV-GIPPPPPLPGAGIPPPPPL--PGA----- 1171
            P PP     PG       AG   P  LP + G P  P  PG+   P   L  PG      
Sbjct: 502  PGPPGSLGFPGQKGEKGQAGATGPKGLPGIPGAPGAPGFPGSKGEPGDILTFPGMKGDKG 561

Query: 1172 --GIPPPPPLPGV-GIPPPPPLPGVGIPPPPPLPGA----GIPPPPPLPGMGIPPAPAPP 1224
              G P  P LPG+ G P    LPG  +P P   PG     G   PP  PG+   P    P
Sbjct: 562  ELGSPGAPGLPGLPGTPGQDGLPG--LPGPKGEPGGITFKGERGPPGNPGLPGLPGNIGP 619

Query: 1225 LPPPGTGIPPP----PLLPVSGPPLLPQV-GSSTLPTPQVCGFLPPPLPS--GLFG-LGM 1276
            + PPG G P P     +  V+G P  P + G    P   +     P LP   G  G +G+
Sbjct: 620  MGPPGFGPPGPVGEKGIQGVAGNPGQPGIPGPKGDPGQTITQPGKPGLPGNPGRDGDVGL 679

Query: 1277 NQDKGSRKQPIEPCRP 1292
              D G   QP  P  P
Sbjct: 680  PGDPGLPGQPGLPGIP 695



 Score = 55.1 bits (131), Expect = 6e-07
 Identities = 74/258 (28%), Positives = 93/258 (36%), Gaps = 44/258 (17%)

Query: 748  PTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPT--Q 805
            P  E G    P V G PG P  P  A  GP+     +      P R         PT  Q
Sbjct: 1221 PKGEPGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQ----GPPGRPG-------PTGFQ 1269

Query: 806  SISQPPPPPSLLWSAG-------QGQPGSQPPHSISTE-----FQTSHEHSVSSAFKNSC 853
             +  P  PP L  + G        GQPG      +  +      Q +      +  K   
Sbjct: 1270 GLPGPEGPPGLPGNGGIKGEKGNPGQPGLPGLPGLKGDQGPPGLQGNPGRPGLNGMKGDP 1329

Query: 854  NIPSPPPLPCTESSSSMPGL-------GMVPPPPPP-LPGMTVPTLPSTAIPQPPPLQGT 905
             +P  P  P  +  S +PG        G++ PP PP LPG +  ++       PP + G 
Sbjct: 1330 GLPGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGPPGLPGPSGQSIIIKGDAGPPGIPGQ 1389

Query: 906  EMLPPPPPPLPGAGIPPPPPLPG-AGILPLPPLPGA-GIPPPPPLPGAAIPPPPPLPGA- 962
              L   P P    G+P P   PG  G   LP   GA G    P LPG         PG  
Sbjct: 1390 PGLKGLPGPQGPQGLPGPTGPPGDPGRNGLPGFDGAGGRKGDPGLPGQ--------PGTR 1441

Query: 963  GIPLPPPLPGAGIPPPPP 980
            G+  PP   G   PP PP
Sbjct: 1442 GLDGPPGPDGLQGPPGPP 1459



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 49/159 (30%), Positives = 57/159 (35%), Gaps = 18/159 (11%)

Query: 255  GPSGGAGEAPGSP----------DTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEA 304
            GPSG  G+ PGSP          D   +   L  LP     EP  P  P +PG       
Sbjct: 1045 GPSGVPGQ-PGSPGLPGQKGDKGDPGISSIGLPGLPGP-KGEPGLPGYPGNPGIKGSVGD 1102

Query: 305  PSLPA--AQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGE-EDAFEDAPRGS 361
            P LP     P AK  P    FP     PG +    P    G   E G           G 
Sbjct: 1103 PGLPGLPGTPGAKGQPGLPGFPGTPGPPGPKGISGPPGNPGLPGEPGPVGGGGHPGQPGP 1162

Query: 362  PGEEWAPEVGEDA-PQRLGEEPEEEAQGPDAPAAASLPG 399
            PGE+  P  G+D  P   G++ E    G   P    LPG
Sbjct: 1163 PGEKGKP--GQDGIPGPAGQKGEPGQPGFGNPGPPGLPG 1199



 Score = 39.3 bits (90), Expect = 0.033
 Identities = 58/241 (24%), Positives = 78/241 (32%), Gaps = 45/241 (18%)

Query: 227 QGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTE-----QALSALSDLPE 281
           +G   P  PP  V P+PG  +      +G  G  G  PG P  +       +     LP 
Sbjct: 333 KGDTGPPGPPGLVIPRPGTGI-----TIGEKGNIG-LPGLPGEKGERGFPGIQGPPGLPG 386

Query: 282 SLAAEPREPQQPP------------SPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAG 329
              A    P  PP             P G+ +   P L   QP A   P       P   
Sbjct: 387 PPGAAVMGPPGPPGFPGERGQKGDEGPPGISIPGPPGLD-GQPGAPGLPGPPGPAGPHIP 445

Query: 330 PGEE----AAGAPVRGAGDTDEEGEEDAFED--------------APRGSPGEEW--APE 369
           P +E        P    GD   +GE+    D               P G PG      P 
Sbjct: 446 PSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPGQPGLPGLPGPP 505

Query: 370 VGEDAPQRLGEEPEEEAQGPDA-PAAASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSS 428
                P + GE+ +  A GP   P     PG+P       +P  ++T   +K    +L S
Sbjct: 506 GSLGFPGQKGEKGQAGATGPKGLPGIPGAPGAPGFPGSKGEPGDILTFPGMKGDKGELGS 565

Query: 429 P 429
           P
Sbjct: 566 P 566



 Score = 36.2 bits (82), Expect = 0.28
 Identities = 47/181 (25%), Positives = 61/181 (33%), Gaps = 38/181 (20%)

Query: 236 PTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPS 295
           P  +  QPGA       L GP G AG  P  P +++              EP  P  P S
Sbjct: 421 PPGLDGQPGA-----PGLPGPPGPAG--PHIPPSDEI------------CEPGPPGPPGS 461

Query: 296 PGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEE-DAF 354
           PG   +     +   +     +   T    P   PG      P    G   ++GE+  A 
Sbjct: 462 PGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPGQPGLPGLPGPPGSLGFPGQKGEKGQAG 521

Query: 355 EDAPRGSPGEEWAPEVGEDAPQRLGEEPEE--------------EAQGPDAPAAASLPGS 400
              P+G PG   AP     AP   G + E               E   P AP    LPG+
Sbjct: 522 ATGPKGLPGIPGAP----GAPGFPGSKGEPGDILTFPGMKGDKGELGSPGAPGLPGLPGT 577

Query: 401 P 401
           P
Sbjct: 578 P 578



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 44/176 (25%), Positives = 60/176 (34%), Gaps = 17/176 (9%)

Query: 231  EPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEA--PGSPDTEQALSALSDLPESLAAEPR 288
            +P  P   +S QPG        L GP G  G    PG P           + +     P+
Sbjct: 989  DPGQP--GLSGQPG--------LPGPPGPKGNPGLPGQPGLIGPPGLKGTIGDMGFPGPQ 1038

Query: 289  EPQQPPSPGGLPVSE-APSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDE 347
              + PP P G+P    +P LP  Q   K  P  ++   P     +   G P        +
Sbjct: 1039 GVEGPPGPSGVPGQPGSPGLP-GQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGNPGIK 1097

Query: 348  EGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAP 403
                D       G+PG +  P +    P   G    +   GP  P    LPG P P
Sbjct: 1098 GSVGDPGLPGLPGTPGAKGQPGL-PGFPGTPGPPGPKGISGP--PGNPGLPGEPGP 1150


>gi|15890088 type IV collagen alpha 5 isoform 3 precursor [Homo
            sapiens]
          Length = 1688

 Score =  168 bits (425), Expect = 5e-41
 Identities = 224/693 (32%), Positives = 260/693 (37%), Gaps = 197/693 (28%)

Query: 750  EEGGVLTLPPVDGLPGRP--------PCPPGAESGPQTKFCSEISLIVSPRRISVQLDSH 801
            + G  +T P   GLPG P        P  PG    P             P     + +  
Sbjct: 654  DPGQTITQPGKPGLPGNPGRDGDVGLPGDPGLPGQPGL-----------PGIPGSKGEPG 702

Query: 802  QPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPP-- 859
             P   +  PP P         G PG  PP +  T  +   E             P PP  
Sbjct: 703  IPGIGLPGPPGPKGF-----PGIPG--PPGAPGTPGRIGLE-----------GPPGPPGF 744

Query: 860  PLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPS-----TAIPQPPPLQGTEMLPPP--- 911
            P P  E   ++PG    PP PP LPG      P         P PP   G + LP P   
Sbjct: 745  PGPKGEPGFALPG----PPGPPGLPGFKGALGPKGDRGFPGPPGPPGRTGLDGLPGPKGD 800

Query: 912  -----------PPPLPGAGI---PPPPPLPG-AGILPLPPLPGAGIPPPPPLPGAAIPPP 956
                       PP LPG G+   P PP +PG  G   L  +PG    P P  PG  +P P
Sbjct: 801  VGPNGQPGPMGPPGLPGIGVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGP--PGLDVPGP 858

Query: 957  ------PPLPGAGIPLPPP----LPG----AGIP----------PPPPLPGAGIPPPPPL 992
                  P +PGA  P+ PP    LPG    +G P          PP P    GIP    +
Sbjct: 859  PGERGSPGIPGAPGPIGPPGSPGLPGKAGASGFPGTKGEMGMMGPPGPPGPLGIPGRSGV 918

Query: 993  PGA----GIPPPPPLPG----AGIPPPPPLPGAGIPPPPPLPGA----GIPPPPPLPGA- 1039
            PG     G+   P LPG     G    P LPG   P  P L G+    G P  P +PG  
Sbjct: 919  PGLKGDDGLQGQPGLPGPTGEKGSKGEPGLPGPPGPMDPNLLGSKGEKGEPGLPGIPGVS 978

Query: 1040 ------GIPPPPPLPG----AGIPPP------PPLPG-AGIPPPPPLPGA----GIP--- 1075
                  G+P  P  PG     G+P P      P LPG  G+  PP L G     G P   
Sbjct: 979  GPKGYQGLPGDPGQPGLSGQPGLPGPPGPKGNPGLPGQPGLIGPPGLKGTIGDMGFPGPQ 1038

Query: 1076 ----PPPPLPGAGIPPPPPLPG---------------AGIPPPPPLPGV-GIPPPPPLPG 1115
                PP P    G P  P LPG                G+P P   PG+ G P  P + G
Sbjct: 1039 GVEGPPGPSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGNPGIKG 1098

Query: 1116 A-GIPPPPPLPGA-GIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIP-PPPPLPGAG 1172
            + G P  P LPG  G    P LPG    P PP P+ GI  PP  P  G+P  P P+ G G
Sbjct: 1099 SVGDPGLPGLPGTPGAKGQPGLPGFPGTPGPPGPK-GISGPPGNP--GLPGEPGPVGGGG 1155

Query: 1173 IPPPPPLPGV-------GIPPP------PPLPGVGIPPPPPLPG----------AGIPPP 1209
             P  P  PG        GIP P      P  PG G P PP LPG           GIP  
Sbjct: 1156 HPGQPGPPGEKGKPGQDGIPGPAGQKGEPGQPGFGNPGPPGLPGLSGQKGDGGLPGIPGN 1215

Query: 1210 PPLPG-------MGIPPAPAPPLPP--PGTGIPPPPLLP-VSGPPLLPQVGSSTLPTPQV 1259
            P LPG        G P    PP PP  PG  +  P   P   GPP  P  G   LP P+ 
Sbjct: 1216 PGLPGPKGEPGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQGPPGRP--GFQGLPGPEG 1273

Query: 1260 CGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRP 1292
                PP LP      G+  +KG+  QP  P  P
Sbjct: 1274 ----PPGLPG---NGGIKGEKGNPGQPGLPGLP 1299



 Score =  163 bits (412), Expect = 2e-39
 Identities = 175/492 (35%), Positives = 198/492 (40%), Gaps = 92/492 (18%)

Query: 856  PSPPPLPCTESSSSMPGLGMVPPPPPPLPGMT-VPTLPST-AIPQPPPLQGTEMLPPPPP 913
            P  P LP        PG G  PP P    G+  V   P    IP P    G  +  P  P
Sbjct: 608  PGLPGLPGNIGPMGPPGFG--PPGPVGEKGIQGVAGNPGQPGIPGPKGDPGQTITQPGKP 665

Query: 914  PLPG-------AGIPPPPPLPGAGILP-------LPPLPGAGIPPPPPLPG-AAIPPPPP 958
             LPG        G+P  P LPG   LP        P +PG G+P PP   G   IP PP 
Sbjct: 666  GLPGNPGRDGDVGLPGDPGLPGQPGLPGIPGSKGEPGIPGIGLPGPPGPKGFPGIPGPPG 725

Query: 959  LPGA-------GIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPG----------AGIPPPP 1001
             PG        G P PP  PG    P   LPG   P PP LPG           G P PP
Sbjct: 726  APGTPGRIGLEGPPGPPGFPGPKGEPGFALPGP--PGPPGLPGFKGALGPKGDRGFPGPP 783

Query: 1002 PLPGA----GIPPPPPLPGAGIPP----PPPLPGAGIPPPPPLPGAGIPPPPPLPGA-GI 1052
              PG     G+P P    G    P    PP LPG G+  PP  P  GIP P   PG  GI
Sbjct: 784  GPPGRTGLDGLPGPKGDVGPNGQPGPMGPPGLPGIGVQGPPGPP--GIPGPIGQPGLHGI 841

Query: 1053 P---PPPPLPGAGIPPPPPLPGAGIPPPPPLPG-AGIPPPPPLPG----AGIPPPPPLPG 1104
            P     P  PG  +P PP   G+  P  P  PG  G P  P LPG    +G P      G
Sbjct: 842  PGEKGDPGPPGLDVPGPPGERGS--PGIPGAPGPIGPPGSPGLPGKAGASGFPGTKGEMG 899

Query: 1105 VGIPPPPPLPGAGIPPPPPLPGA----GIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGA 1160
            +  PP PP P  GIP    +PG     G+   P LPG       P    G    P LPG 
Sbjct: 900  MMGPPGPPGP-LGIPGRSGVPGLKGDDGLQGQPGLPG-------PTGEKGSKGEPGLPGP 951

Query: 1161 GIPPPPPLPGA-GIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGM-GIP 1218
              P  P L G+ G    P LPG+        PGV      P    G+P  P  PG+ G P
Sbjct: 952  PGPMDPNLLGSKGEKGEPGLPGI--------PGVS----GPKGYQGLPGDPGQPGLSGQP 999

Query: 1219 PAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGL---- 1274
              P PP P    G+P  P L +  P L   +G    P PQ  G   PP PSG+ G     
Sbjct: 1000 GLPGPPGPKGNPGLPGQPGL-IGPPGLKGTIGDMGFPGPQ--GVEGPPGPSGVPGQPGSP 1056

Query: 1275 GMNQDKGSRKQP 1286
            G+   KG +  P
Sbjct: 1057 GLPGQKGDKGDP 1068



 Score =  153 bits (387), Expect = 1e-36
 Identities = 214/662 (32%), Positives = 248/662 (37%), Gaps = 158/662 (23%)

Query: 759  PVDGLPGRP--------PCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQP 810
            P  GLPG P        P PPGA   P       I L   P          +P  ++  P
Sbjct: 704  PGIGLPGPPGPKGFPGIPGPPGAPGTP-----GRIGLEGPPGPPGFPGPKGEPGFALPGP 758

Query: 811  PPPPSLLWSAG-------QGQPGSQ-PPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLP 862
            P PP L    G       +G PG   PP     +     +  V     N    P  PP  
Sbjct: 759  PGPPGLPGFKGALGPKGDRGFPGPPGPPGRTGLDGLPGPKGDVGP---NGQPGPMGPP-- 813

Query: 863  CTESSSSMPGLGMVPPPPPP-------------LPGMTV-PTLPSTAIPQPPPLQGTEML 908
                   +PG+G+  PP PP             +PG    P  P   +P PP  +G+  +
Sbjct: 814  ------GLPGIGVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGPPGLDVPGPPGERGSPGI 867

Query: 909  PPPPPPLPGAGIPPPPPLPG-AGILPLPPLPGA-GIPPPPPLPGA-AIPPPPPLPGA--- 962
            P  P P+   G P  P LPG AG    P   G  G+  PP  PG   IP    +PG    
Sbjct: 868  PGAPGPI---GPPGSPGLPGKAGASGFPGTKGEMGMMGPPGPPGPLGIPGRSGVPGLKGD 924

Query: 963  -GIPLPPPLPGA----GIPPPPPLPGAGIPPPPPLPGA----GIPPPPPLPGA------- 1006
             G+   P LPG     G    P LPG   P  P L G+    G P  P +PG        
Sbjct: 925  DGLQGQPGLPGPTGEKGSKGEPGLPGPPGPMDPNLLGSKGEKGEPGLPGIPGVSGPKGYQ 984

Query: 1007 GIPPPPPLPGA----GIPPPPP------LPGA-GIPPPPPLPGA----GIPPP-----PP 1046
            G+P  P  PG     G+P PP       LPG  G+  PP L G     G P P     PP
Sbjct: 985  GLPGDPGQPGLSGQPGLPGPPGPKGNPGLPGQPGLIGPPGLKGTIGDMGFPGPQGVEGPP 1044

Query: 1047 LPGA--GIPPPPPLPGA---------------GIPPPPPLPGA-GIPPPPPLPGA----G 1084
             P    G P  P LPG                G+P P   PG  G P  P + G+    G
Sbjct: 1045 GPSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGNPGIKGSVGDPG 1104

Query: 1085 IPPPPPLPGA-GIPPPPPLPGVGIPPPP-----PLPGAGIPPPP-PLPGAGIPPPPPLPG 1137
            +P  P  PGA G P  P  PG   PP P     P    G+P  P P+ G G P  P  PG
Sbjct: 1105 LPGLPGTPGAKGQPGLPGFPGTPGPPGPKGISGPPGNPGLPGEPGPVGGGGHPGQPGPPG 1164

Query: 1138 A-------GIPPP------PPLPRVGIPPPPPLPGA----------GIPPPPPLPGA-GI 1173
                    GIP P      P  P  G P PP LPG           GIP  P LPG  G 
Sbjct: 1165 EKGKPGQDGIPGPAGQKGEPGQPGFGNPGPPGLPGLSGQKGDGGLPGIPGNPGLPGPKGE 1224

Query: 1174 PPPPPLPGVGIPPPPP-LPGVGIPPPPPLPGAGIPPPPPLPG-MGIPPAPAPPLPPPGTG 1231
            P     PGV  PP PP  PG  +  P   PG     PP  PG  G+P    PP  P   G
Sbjct: 1225 PGFHGFPGVQGPPGPPGSPGPALEGPKGNPGP--QGPPGRPGFQGLPGPEGPPGLPGNGG 1282

Query: 1232 IPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGL-GMNQDKGSRKQPIEPC 1290
            I      P  G P LP +       P + G   PP   G  G  G+N  KG    P  P 
Sbjct: 1283 IKGEKGNP--GQPGLPGL-------PGLKGDQGPPGLQGNPGRPGLNGMKGDPGLPGVPG 1333

Query: 1291 RP 1292
             P
Sbjct: 1334 FP 1335



 Score =  152 bits (385), Expect = 2e-36
 Identities = 211/639 (33%), Positives = 238/639 (37%), Gaps = 159/639 (24%)

Query: 748  PTEEG--GVLTLPPVDGLPGRPPCP--PGAESGPQTKFCSEISLIVSPRRISVQLDSHQP 803
            P E G  G+   P   G PG P  P   GA   P TK   E+ ++  P            
Sbjct: 859  PGERGSPGIPGAPGPIGPPGSPGLPGKAGASGFPGTK--GEMGMMGPPG----------- 905

Query: 804  TQSISQPPPPPSLLWSAG----------QGQPGSQPPHSISTEFQTSHEHSVSSAFKNSC 853
                  PP P  +   +G          QGQPG   P        T  + S         
Sbjct: 906  ------PPGPLGIPGRSGVPGLKGDDGLQGQPGLPGP--------TGEKGSKGEPGLPGP 951

Query: 854  NIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPT----LPSTAIPQPPPLQGTEMLP 909
              P  P L  ++     PGL       P +PG++ P     LP    P  P L G   LP
Sbjct: 952  PGPMDPNLLGSKGEKGEPGL-------PGIPGVSGPKGYQGLPGD--PGQPGLSGQPGLP 1002

Query: 910  PPPPPLPGAGIPPPPPLPGA-------GILPLPPLPGAGIPPPPP-LPGAAIPPPPPLPG 961
             PP P    G+P  P L G        G +  P   G   PP P  +PG   P  P LPG
Sbjct: 1003 GPPGPKGNPGLPGQPGLIGPPGLKGTIGDMGFPGPQGVEGPPGPSGVPGQ--PGSPGLPG 1060

Query: 962  A------------GIP-LPPPLPGAGIPPPPPLPG----AGIPPPPPLPGA-GIPPPPPL 1003
                         G+P LP P    G+P  P  PG     G P  P LPG  G    P L
Sbjct: 1061 QKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGNPGIKGSVGDPGLPGLPGTPGAKGQPGL 1120

Query: 1004 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP-PLPGAGIPPPPPLPGA-GIPPPPPLPG- 1060
            PG    P PP P  GI  PP  PG  +P  P P+ G G P  P  PG  G P    +PG 
Sbjct: 1121 PGFPGTPGPPGP-KGISGPPGNPG--LPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGP 1177

Query: 1061 AGIPPPPPLPGAGIPPPPPLPGA----------GIPPPPPLPGA-GIPPPPPLPGVGIPP 1109
            AG    P  PG G P PP LPG           GIP  P LPG  G P     PGV  PP
Sbjct: 1178 AGQKGEPGQPGFGNPGPPGLPGLSGQKGDGGLPGIPGNPGLPGPKGEPGFHGFPGVQGPP 1237

Query: 1110 PPP-LPGAGIPPPPPLPGAGIPPPPP----LPGAGIPPPPP-----LPRVGIPPPPPLPG 1159
             PP  PG  +  P   PG   PP  P    LPG   PP  P         G P  P LPG
Sbjct: 1238 GPPGSPGPALEGPKGNPGPQGPPGRPGFQGLPGPEGPPGLPGNGGIKGEKGNPGQPGLPG 1297

Query: 1160 A----GIPPPPPLPGA-------GIPPPPPLPGV----GIPPPPPLPG----------VG 1194
                 G   PP L G        G+   P LPGV    G+  P  +PG          +G
Sbjct: 1298 LPGLKGDQGPPGLQGNPGRPGLNGMKGDPGLPGVPGFPGMKGPSGVPGSAGPEGEPGLIG 1357

Query: 1195 IPPPPPLPG-----------AGIPPPPPLPGMGIPPAPAPPLPPPG-TGIPPPPLLPVSG 1242
             P PP LPG           AG P  P  PG+   P P  P   PG TG P  P     G
Sbjct: 1358 PPGPPGLPGPSGQSIIIKGDAGPPGIPGQPGLKGLPGPQGPQGLPGPTGPPGDP-----G 1412

Query: 1243 PPLLP-------QVGSSTLP-TPQVCGFLPPPLPSGLFG 1273
               LP       + G   LP  P   G   PP P GL G
Sbjct: 1413 RNGLPGFDGAGGRKGDPGLPGQPGTRGLDGPPGPDGLQG 1451



 Score =  147 bits (370), Expect = 1e-34
 Identities = 194/580 (33%), Positives = 222/580 (38%), Gaps = 92/580 (15%)

Query: 753  GVLTLPPVDGLPGRPPCP-PGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPP 811
            GV  L   DGL G+P  P P  E G +     E  L   P  +   L   +  +     P
Sbjct: 917  GVPGLKGDDGLQGQPGLPGPTGEKGSK----GEPGLPGPPGPMDPNLLGSKGEKGEPGLP 972

Query: 812  PPPSLLWSAG-QGQPGS--QPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSS 868
              P +    G QG PG   QP  S             +        +  PP L  T    
Sbjct: 973  GIPGVSGPKGYQGLPGDPGQPGLSGQPGLPGPPGPKGNPGLPGQPGLIGPPGLKGTIGDM 1032

Query: 869  SMPGLGMVPPPPPP--LPGMT-VPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPP 925
              PG   V  PP P  +PG    P LP     +  P   +  LP  P P    G+P  P 
Sbjct: 1033 GFPGPQGVEGPPGPSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPG 1092

Query: 926  LPG----AGILPLPPLPGA-GIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPP- 979
             PG     G   LP LPG  G    P LPG    P PP P  GI  PP  PG  +P  P 
Sbjct: 1093 NPGIKGSVGDPGLPGLPGTPGAKGQPGLPGFPGTPGPPGP-KGISGPPGNPG--LPGEPG 1149

Query: 980  PLPGAGIPPPPPLPGA-GIPPPPPLPG-AGIPPPPPLPGAGIPPPPPLPGA--------- 1028
            P+ G G P  P  PG  G P    +PG AG    P  PG G P PP LPG          
Sbjct: 1150 PVGGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGEPGQPGFGNPGPPGLPGLSGQKGDGGL 1209

Query: 1029 -GIPPPPPLPGA-GIPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPGAGIPPPPP----LP 1081
             GIP  P LPG  G P     PG   PP PP  PG  +  P   PG   PP  P    LP
Sbjct: 1210 PGIPGNPGLPGPKGEPGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQGPPGRPGFQGLP 1269

Query: 1082 GAGIPPPPPLPGA-----GIPPPPPLPGV----GIPPPPPLPGA-------GIPPPPPLP 1125
            G   PP  P  G      G P  P LPG+    G   PP L G        G+   P LP
Sbjct: 1270 GPEGPPGLPGNGGIKGEKGNPGQPGLPGLPGLKGDQGPPGLQGNPGRPGLNGMKGDPGLP 1329

Query: 1126 GA----GIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGA--------GIPPPPPLPGAGI 1173
            G     G+  P  +PG+  P   P   +G P PP LPG         G   PP     GI
Sbjct: 1330 GVPGFPGMKGPSGVPGSAGPEGEP-GLIGPPGPPGLPGPSGQSIIIKGDAGPP-----GI 1383

Query: 1174 PPPPPLPGVGIPPPPP-LPGVGIPPPPP----LPG----------AGIPPPPPLPGMGIP 1218
            P  P L G+  P  P  LPG   PP  P    LPG           G+P  P   G+  P
Sbjct: 1384 PGQPGLKGLPGPQGPQGLPGPTGPPGDPGRNGLPGFDGAGGRKGDPGLPGQPGTRGLDGP 1443

Query: 1219 PAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQ 1258
            P P     PPG    PP    V+   L+ +  S T   PQ
Sbjct: 1444 PGPDGLQGPPG----PPGTSSVAHGFLITR-HSQTTDAPQ 1478



 Score =  139 bits (349), Expect = 3e-32
 Identities = 211/676 (31%), Positives = 240/676 (35%), Gaps = 160/676 (23%)

Query: 751  EGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQP 810
            E G    P ++G PG P  P G E  P  +       I  P             + I  P
Sbjct: 46   EKGERGFPGLEGHPGLPGFP-GPEGPPGPRGQKGDDGIPGP----------PGPKGIRGP 94

Query: 811  PPPPSLLWSAG----QGQPGSQPPHSISTEFQTSHEHSV--SSAFKNSCNIPSPPPLPCT 864
            P  P    + G     G  G+  P  I     T  E     S  F      P PP +P  
Sbjct: 95   PGLPGFPGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGM 154

Query: 865  ESS------SSMPGLGMVP--PPPPPLPGMTVPT-LPST-AIPQPPPLQGTEMLPPPPPP 914
            +        SS+PG    P  P PP + G+  PT +P     P PP L G    PP PP 
Sbjct: 155  KGEPGSIIMSSLPGPKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMG----PPGPPG 210

Query: 915  LPGA------------------GIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPP 956
            LPG                   G+  PP  PG       P+          LPG   PP 
Sbjct: 211  LPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQKGDQGLPGDRGPPG 270

Query: 957  PPLPGAGIPLPPPLPGA--------GIPPPPPLPGA----GIPPPPPLPG-AGIPPPPPL 1003
            PP    GI  PP  PG         G P     PG     G P  P LPG  G P  P  
Sbjct: 271  PP----GIRGPPGPPGGEKGEKGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGR 326

Query: 1004 PGA----GIPPPPPLPGAGIPPP--------------PPLPGA-------GIPPPPPLPG 1038
             G     G   PP  PG  IP P              P LPG        GI  PP LPG
Sbjct: 327  DGEKGQKGDTGPPGPPGLVIPRPGTGITIGEKGNIGLPGLPGEKGERGFPGIQGPPGLPG 386

Query: 1039 AGIPPPPPLPGAGIPPPPPLPGA-GIPPPPPLPGAGIPPPPPL---PGA-GIPPPPPLPG 1093
                 PP     G P PP  PG  G       PG  IP PP L   PGA G+P PP   G
Sbjct: 387  -----PPGAAVMGPPGPPGFPGERGQKGDEGPPGISIPGPPGLDGQPGAPGLPGPPGPAG 441

Query: 1094 AGIPPPPPLPGVGIPPPPPLPG-----------------------AGIPPPPPLPGA-GI 1129
              IPP   +   G P PP  PG                        GI  PP  PG  G+
Sbjct: 442  PHIPPSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPGQPGLPGL 501

Query: 1130 PPPPP---LPG-------AGIPPPPPLPRV-GIPPPPPLPGAGIPPPPPL--PGA----- 1171
            P PP     PG       AG   P  LP + G P  P  PG+   P   L  PG      
Sbjct: 502  PGPPGSLGFPGQKGEKGQAGATGPKGLPGIPGAPGAPGFPGSKGEPGDILTFPGMKGDKG 561

Query: 1172 --GIPPPPPLPGV-GIPPPPPLPGVGIPPPPPLPGA----GIPPPPPLPGMGIPPAPAPP 1224
              G P  P LPG+ G P    LPG  +P P   PG     G   PP  PG+   P    P
Sbjct: 562  ELGSPGAPGLPGLPGTPGQDGLPG--LPGPKGEPGGITFKGERGPPGNPGLPGLPGNIGP 619

Query: 1225 LPPPGTGIPPP----PLLPVSGPPLLPQV-GSSTLPTPQVCGFLPPPLPS--GLFG-LGM 1276
            + PPG G P P     +  V+G P  P + G    P   +     P LP   G  G +G+
Sbjct: 620  MGPPGFGPPGPVGEKGIQGVAGNPGQPGIPGPKGDPGQTITQPGKPGLPGNPGRDGDVGL 679

Query: 1277 NQDKGSRKQPIEPCRP 1292
              D G   QP  P  P
Sbjct: 680  PGDPGLPGQPGLPGIP 695



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 72/256 (28%), Positives = 91/256 (35%), Gaps = 43/256 (16%)

Query: 748  PTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSI 807
            P  E G    P V G PG P  P  A  GP+     +      P R   Q         +
Sbjct: 1221 PKGEPGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQ----GPPGRPGFQ--------GL 1268

Query: 808  SQPPPPPSLLWSAG-------QGQPGSQPPHSISTE-----FQTSHEHSVSSAFKNSCNI 855
              P  PP L  + G        GQPG      +  +      Q +      +  K    +
Sbjct: 1269 PGPEGPPGLPGNGGIKGEKGNPGQPGLPGLPGLKGDQGPPGLQGNPGRPGLNGMKGDPGL 1328

Query: 856  PSPPPLPCTESSSSMPGL-------GMVPPPPPP-LPGMTVPTLPSTAIPQPPPLQGTEM 907
            P  P  P  +  S +PG        G++ PP PP LPG +  ++       PP + G   
Sbjct: 1329 PGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGPPGLPGPSGQSIIIKGDAGPPGIPGQPG 1388

Query: 908  LPPPPPPLPGAGIPPPPPLPG-AGILPLPPLPGA-GIPPPPPLPGAAIPPPPPLPGA-GI 964
            L   P P    G+P P   PG  G   LP   GA G    P LPG         PG  G+
Sbjct: 1389 LKGLPGPQGPQGLPGPTGPPGDPGRNGLPGFDGAGGRKGDPGLPGQ--------PGTRGL 1440

Query: 965  PLPPPLPGAGIPPPPP 980
              PP   G   PP PP
Sbjct: 1441 DGPPGPDGLQGPPGPP 1456



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 49/159 (30%), Positives = 57/159 (35%), Gaps = 18/159 (11%)

Query: 255  GPSGGAGEAPGSP----------DTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEA 304
            GPSG  G+ PGSP          D   +   L  LP     EP  P  P +PG       
Sbjct: 1045 GPSGVPGQ-PGSPGLPGQKGDKGDPGISSIGLPGLPGP-KGEPGLPGYPGNPGIKGSVGD 1102

Query: 305  PSLPA--AQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGE-EDAFEDAPRGS 361
            P LP     P AK  P    FP     PG +    P    G   E G           G 
Sbjct: 1103 PGLPGLPGTPGAKGQPGLPGFPGTPGPPGPKGISGPPGNPGLPGEPGPVGGGGHPGQPGP 1162

Query: 362  PGEEWAPEVGEDA-PQRLGEEPEEEAQGPDAPAAASLPG 399
            PGE+  P  G+D  P   G++ E    G   P    LPG
Sbjct: 1163 PGEKGKP--GQDGIPGPAGQKGEPGQPGFGNPGPPGLPG 1199



 Score = 39.3 bits (90), Expect = 0.033
 Identities = 58/241 (24%), Positives = 78/241 (32%), Gaps = 45/241 (18%)

Query: 227 QGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTE-----QALSALSDLPE 281
           +G   P  PP  V P+PG  +      +G  G  G  PG P  +       +     LP 
Sbjct: 333 KGDTGPPGPPGLVIPRPGTGI-----TIGEKGNIG-LPGLPGEKGERGFPGIQGPPGLPG 386

Query: 282 SLAAEPREPQQPP------------SPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAG 329
              A    P  PP             P G+ +   P L   QP A   P       P   
Sbjct: 387 PPGAAVMGPPGPPGFPGERGQKGDEGPPGISIPGPPGLD-GQPGAPGLPGPPGPAGPHIP 445

Query: 330 PGEE----AAGAPVRGAGDTDEEGEEDAFED--------------APRGSPGEEW--APE 369
           P +E        P    GD   +GE+    D               P G PG      P 
Sbjct: 446 PSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPGQPGLPGLPGPP 505

Query: 370 VGEDAPQRLGEEPEEEAQGPDA-PAAASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSS 428
                P + GE+ +  A GP   P     PG+P       +P  ++T   +K    +L S
Sbjct: 506 GSLGFPGQKGEKGQAGATGPKGLPGIPGAPGAPGFPGSKGEPGDILTFPGMKGDKGELGS 565

Query: 429 P 429
           P
Sbjct: 566 P 566



 Score = 36.2 bits (82), Expect = 0.28
 Identities = 47/181 (25%), Positives = 61/181 (33%), Gaps = 38/181 (20%)

Query: 236 PTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPS 295
           P  +  QPGA       L GP G AG  P  P +++              EP  P  P S
Sbjct: 421 PPGLDGQPGA-----PGLPGPPGPAG--PHIPPSDEI------------CEPGPPGPPGS 461

Query: 296 PGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEE-DAF 354
           PG   +     +   +     +   T    P   PG      P    G   ++GE+  A 
Sbjct: 462 PGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPGQPGLPGLPGPPGSLGFPGQKGEKGQAG 521

Query: 355 EDAPRGSPGEEWAPEVGEDAPQRLGEEPEE--------------EAQGPDAPAAASLPGS 400
              P+G PG   AP     AP   G + E               E   P AP    LPG+
Sbjct: 522 ATGPKGLPGIPGAP----GAPGFPGSKGEPGDILTFPGMKGDKGELGSPGAPGLPGLPGT 577

Query: 401 P 401
           P
Sbjct: 578 P 578



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 44/176 (25%), Positives = 60/176 (34%), Gaps = 17/176 (9%)

Query: 231  EPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEA--PGSPDTEQALSALSDLPESLAAEPR 288
            +P  P   +S QPG        L GP G  G    PG P           + +     P+
Sbjct: 989  DPGQP--GLSGQPG--------LPGPPGPKGNPGLPGQPGLIGPPGLKGTIGDMGFPGPQ 1038

Query: 289  EPQQPPSPGGLPVSE-APSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDE 347
              + PP P G+P    +P LP  Q   K  P  ++   P     +   G P        +
Sbjct: 1039 GVEGPPGPSGVPGQPGSPGLP-GQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGNPGIK 1097

Query: 348  EGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAP 403
                D       G+PG +  P +    P   G    +   GP  P    LPG P P
Sbjct: 1098 GSVGDPGLPGLPGTPGAKGQPGL-PGFPGTPGPPGPKGISGP--PGNPGLPGEPGP 1150


>gi|40548415 dishevelled associated activator of morphogenesis 2 [Homo
            sapiens]
          Length = 1067

 Score =  167 bits (423), Expect = 8e-41
 Identities = 152/531 (28%), Positives = 242/531 (45%), Gaps = 78/531 (14%)

Query: 1174 PPPP--PLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTG 1231
            PPPP  PL          LP    PPPPPLP A  PPPPP           PPLPP G  
Sbjct: 522  PPPPGGPLTLSSSMTTNDLP----PPPPPLPFACCPPPPP-----------PPLPPGGPP 566

Query: 1232 IPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCR 1291
             PP        PP L       LP PQ       P PS    L        +K+  +P  
Sbjct: 567  TPP------GAPPCL----GMGLPLPQ------DPYPSSDVPL-------RKKRVPQPSH 603

Query: 1292 PMKPLYWTRIQLHSKRDSSTSLIWEKIEEPSI----DCHEFEELFSKTAVKERKKPISDT 1347
            P+K   W  ++L+ +R   T  +W +I++  +    D  +FE++FS  A +  +K +  T
Sbjct: 604  PLKSFNW--VKLNEERVPGT--VWNEIDDMQVFRILDLEDFEKMFS--AYQRHQKELGST 657

Query: 1348 ISKTKAKQVVKLLS---NKRSQAVGILMSSLHLDMKDIQHAVVNLDNSV-VDLETLQALY 1403
                 A + VK LS    +R+Q   IL+S L L  ++I+ A++ +D    +  + L+ L 
Sbjct: 658  EDIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLL 717

Query: 1404 ENRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYELSLIPNFSERVFCILFQSTFSES 1463
            +   +  +++ +E+H      K   + + + ++FLYE+S I ++ +R+  + F+  F E 
Sbjct: 718  KFIPEKSDIDLLEEH------KHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQER 771

Query: 1464 ICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNYMNGGNKTRGQADGFGLDILPKLK 1523
            +   + K+E +      L     + Q+L ++LA GN+MN G   RG A GF +  L K+ 
Sbjct: 772  LAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQ--RGGAYGFRVASLNKIA 829

Query: 1524 DVKSS-DNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLPEPQDLFQASQMKFEDFQKDLRK 1582
            D KSS D + SLL Y++    ++F +       L  LPE      A+++   + +K++  
Sbjct: 830  DTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPE------AAKVNLAELEKEVGN 883

Query: 1583 LKKDLKACEVEAGKVYQVSSKEHMQPFKENMEQFIIQAKIDQEAEENSLTETHKCFLETT 1642
            L++ L+A EV   +  QV  +E    F   M  FI  +       E+ L E    F +  
Sbjct: 884  LRRGLRAVEVLEYQRRQV--REPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKAL 941

Query: 1643 AYFFMKPKLGEKEVSPNAFFSIWHEFSSDFKDFWKKENKLLLQERVKEAEE 1693
             +F       + ++ P+ FF I+  F   F +       L    R KE EE
Sbjct: 942  MHFGEH----DSKMQPDEFFGIFDTFLQAFSE---ARQDLEAMRRRKEEEE 985



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 38/94 (40%), Positives = 43/94 (45%), Gaps = 23/94 (24%)

Query: 909 PPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPP 968
           P   PP      PP  PL  +  +    LP    PPPPPLP A  PPPP         PP
Sbjct: 518 PVSSPP------PPGGPLTLSSSMTTNDLP----PPPPPLPFACCPPPP---------PP 558

Query: 969 PLPGAGIPPPPPLP---GAGIP-PPPPLPGAGIP 998
           PLP  G P PP  P   G G+P P  P P + +P
Sbjct: 559 PLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDVP 592



 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 41/95 (43%), Positives = 45/95 (47%), Gaps = 24/95 (25%)

Query: 1105 VGIPPPP--PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGI 1162
            V  PPPP  PL  +       LP    PPPPPLP A  PP         PPPPPLP  G 
Sbjct: 519  VSSPPPPGGPLTLSSSMTTNDLP----PPPPPLPFACCPP---------PPPPPLPPGG- 564

Query: 1163 PPPPPLPGAGIPPPPPLPGVGIP-PPPPLPGVGIP 1196
              PP  PGA     PP  G+G+P P  P P   +P
Sbjct: 565  --PPTPPGA-----PPCLGMGLPLPQDPYPSSDVP 592



 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 34/80 (42%), Positives = 40/80 (50%), Gaps = 14/80 (17%)

Query: 957  PPLPGAGIPLPPPLPGAGI-PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1015
            PP PG  + L   +    + PPPPPLP A  PP         PPPPPLP  G P PP  P
Sbjct: 522  PPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPP---------PPPPPLPPGGPPTPPGAP 572

Query: 1016 ---GAGIP-PPPPLPGAGIP 1031
               G G+P P  P P + +P
Sbjct: 573  PCLGMGLPLPQDPYPSSDVP 592



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 40/100 (40%), Positives = 44/100 (44%), Gaps = 30/100 (30%)

Query: 856 PSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPL 915
           P PP  P T SSS       +PPPPPPLP    P                   PPPPPPL
Sbjct: 522 PPPPGGPLTLSSSMTTN--DLPPPPPPLPFACCP-------------------PPPPPPL 560

Query: 916 PGAGIPPPPPLPGAGILPLPPLPGAGIP-PPPPLPGAAIP 954
           P  G   PP  PGA     PP  G G+P P  P P + +P
Sbjct: 561 PPGG---PPTPPGA-----PPCLGMGLPLPQDPYPSSDVP 592



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 37/84 (44%), Positives = 41/84 (48%), Gaps = 19/84 (22%)

Query: 987  PPPP--PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1044
            PPPP  PL  +       LP    PPPPPLP A  PP         PPPPPLP  G P P
Sbjct: 522  PPPPGGPLTLSSSMTTNDLP----PPPPPLPFACCPP---------PPPPPLPPGGPPTP 568

Query: 1045 PPLP---GAGIP-PPPPLPGAGIP 1064
            P  P   G G+P P  P P + +P
Sbjct: 569  PGAPPCLGMGLPLPQDPYPSSDVP 592



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 37/84 (44%), Positives = 41/84 (48%), Gaps = 19/84 (22%)

Query: 1020 PPPP--PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1077
            PPPP  PL  +       LP    PPPPPLP A  PP         PPPPPLP  G P P
Sbjct: 522  PPPPGGPLTLSSSMTTNDLP----PPPPPLPFACCPP---------PPPPPLPPGGPPTP 568

Query: 1078 PPLP---GAGIP-PPPPLPGAGIP 1097
            P  P   G G+P P  P P + +P
Sbjct: 569  PGAPPCLGMGLPLPQDPYPSSDVP 592



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 43/105 (40%), Positives = 49/105 (46%), Gaps = 28/105 (26%)

Query: 1053 PPPP--PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPP 1110
            PPPP  PL  +       LP    PPPPPLP A  PP         PPPPPLP  G   P
Sbjct: 522  PPPPGGPLTLSSSMTTNDLP----PPPPPLPFACCPP---------PPPPPLPPGG---P 565

Query: 1111 PPLPGAGIPPPPPLPGAGIP-PPPPLPGAGIPPPPPLPRVGIPPP 1154
            P  PGA     PP  G G+P P  P P + +    PL +  +P P
Sbjct: 566  PTPPGA-----PPCLGMGLPLPQDPYPSSDV----PLRKKRVPQP 601



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 34/88 (38%), Positives = 40/88 (45%), Gaps = 19/88 (21%)

Query: 1089 PPLPGAGIPPPPPLPGVGI-PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1147
            PP PG  +     +    + PPPPPLP A  PP         PPPPPLP  G P P    
Sbjct: 522  PPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPP---------PPPPPLPPGGPPTP---- 568

Query: 1148 RVGIPPPPPLPGAGIP-PPPPLPGAGIP 1174
                P  PP  G G+P P  P P + +P
Sbjct: 569  ----PGAPPCLGMGLPLPQDPYPSSDVP 592



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 35/95 (36%), Positives = 42/95 (44%), Gaps = 23/95 (24%)

Query: 930  GILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPP 989
            G +  PP PG  +     +    +PPPPP          PLP A  PPP         PP
Sbjct: 517  GPVSSPPPPGGPLTLSSSMTTNDLPPPPP----------PLPFACCPPP---------PP 557

Query: 990  PPLPGAGIPPPPPLP---GAGIP-PPPPLPGAGIP 1020
            PPLP  G P PP  P   G G+P P  P P + +P
Sbjct: 558  PPLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDVP 592



 Score = 39.7 bits (91), Expect = 0.026
 Identities = 34/116 (29%), Positives = 39/116 (33%), Gaps = 22/116 (18%)

Query: 800 SHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPP 859
           S   T  +S PPPP   L  +        PP      F               C  P PP
Sbjct: 512 SELSTGPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFAC-------------CPPPPPP 558

Query: 860 PLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPL 915
           PLP        PG    PP  PP  GM +P LP    P        + +P P  PL
Sbjct: 559 PLP--------PGGPPTPPGAPPCLGMGLP-LPQDPYPSSDVPLRKKRVPQPSHPL 605


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score =  167 bits (422), Expect = 1e-40
 Identities = 146/413 (35%), Positives = 148/413 (35%), Gaps = 61/413 (14%)

Query: 859  PPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEML--PPPPPPLP 916
            P L       + P  G  P  PP  PG           PQ PP QG      PPPPP   
Sbjct: 29   PSLIAGNPQGAPPQGGNKPQGPPSPPGK----------PQGPPPQGGNQPQGPPPPP--- 75

Query: 917  GAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIP 976
              G P  PP  G      PP PG    PPP    +  P  PP    G P  PP  G   P
Sbjct: 76   --GKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPP----GKPQGPPPQGGNQP 129

Query: 977  PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP--------PLPGAGIPPPPPLPGA 1028
              PP P  G P  PP  G   P  PP PG    PPP             G P  PP  G 
Sbjct: 130  QGPP-PPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGG 188

Query: 1029 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP----PLPGAGIPP-----PPP 1079
              P  PP P  G P  PP  G   P  PP PG    PPP        A  PP     PPP
Sbjct: 189  NQPQGPP-PPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPP 247

Query: 1080 LPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPP--------PLPGAGIPP 1131
              G     PPP PG   P  PP  G   P  PP PG    PPP             G P 
Sbjct: 248  QGGNQPQGPPPPPGK--PQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQ 305

Query: 1132 PPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPP--------PLPGVG 1183
             PP  G   P  PP P  G P  PP  G   P  PP PG    PPP             G
Sbjct: 306  GPPPQGGNQPQGPP-PPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPG 364

Query: 1184 IPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPP 1236
             P  PP      P  PP P  G P  P  P  G P    PP PP G     PP
Sbjct: 365  KPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQP--QGPPRPPQGGRPSRPP 415



 Score =  146 bits (368), Expect = 2e-34
 Identities = 142/398 (35%), Positives = 146/398 (36%), Gaps = 70/398 (17%)

Query: 940  AGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 999
            AG P   P  G   P  PP P  G P  PP  G   P  PP P  G P  PP  G   P 
Sbjct: 33   AGNPQGAPPQGGNKPQGPPSP-PGKPQGPPPQGGNQPQGPP-PPPGKPQGPPPQGGNKPQ 90

Query: 1000 PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1059
             PP PG    PPP    +  P  PP    G P  PP  G   P  PP       PPP   
Sbjct: 91   GPPPPGKPQGPPPQGDKSRSPRSPP----GKPQGPPPQGGNQPQGPP-------PPP--- 136

Query: 1060 GAGIPPPPPLPGAGIPPPPPLPGAGIPPPP--------PLPGAGIPPPPPLPGVGIPPPP 1111
              G P  PP  G   P  PP PG    PPP             G P  PP  G   P  P
Sbjct: 137  --GKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGP 194

Query: 1112 PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP--------PLPRVGIPPPPPLPGAGIP 1163
            P P  G P  PP  G   P  PP PG    PPP             G P  PP  G   P
Sbjct: 195  P-PPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQP 253

Query: 1164 PPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPP----PLPGAGIPP-----PPPLPG 1214
              PP P  G P  PP  G   P  PP PG    PPP        +  PP     PPP  G
Sbjct: 254  QGPP-PPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGG 312

Query: 1215 ---MGIPPAPAPPLPPPGTG-----IPPPPLLPVSGPPLLPQVGSSTLPT---------- 1256
                G PP P  P  PP  G      PPPP  P  GPP  PQ GS +             
Sbjct: 313  NQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKP-QGPP--PQGGSKSRSARSPPGKPQGP 369

Query: 1257 PQVCGFLP--PPLPSGLFGLGMNQDKGSRKQPIEPCRP 1292
            PQ  G  P  PP P+G  G           QP  P RP
Sbjct: 370  PQQEGNNPQGPPPPAG--GNPQQPQAPPAGQPQGPPRP 405



 Score =  135 bits (340), Expect = 3e-31
 Identities = 129/400 (32%), Positives = 138/400 (34%), Gaps = 48/400 (12%)

Query: 758  PPVDG-LPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQP--PPPP 814
            PP  G  P  PP PPG   GP  +  ++      P           P Q  ++P  PPPP
Sbjct: 40   PPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPG----KPQGPPPQGGNKPQGPPPP 95

Query: 815  SLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLG 874
                    G+P   PP    +    S             N P  PP P  +     P  G
Sbjct: 96   --------GKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGG 147

Query: 875  MVP--PPPPPLPGMTVPT---------LPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPP 923
              P  PPPP  P    P           P      PPP  G +   PPPPP    G P  
Sbjct: 148  NKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPP----GKPQG 203

Query: 924  PPLPGAGILPLPPLPGAGIPPPPP----LPGAAIPP-----PPPLPGAGIPLPPPLPGAG 974
            PP  G      PP PG    PPP        A  PP     PPP  G     PPP PG  
Sbjct: 204  PPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGK- 262

Query: 975  IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1034
             P  PP  G   P  PP PG    P  P P  G          G P  PP  G   P  P
Sbjct: 263  -PQGPPPQGGNKPQGPPPPG---KPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGP 318

Query: 1035 PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA 1094
            P P  G P  PP  G   P  PP PG    P  P P  G          G P  PP    
Sbjct: 319  P-PPPGKPQGPPPQGGNKPQGPPPPG---KPQGPPPQGGSKSRSARSPPGKPQGPPQQEG 374

Query: 1095 GIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1134
              P  PP P  G P  P  P AG P  PP P  G  P  P
Sbjct: 375  NNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRP 414



 Score =  126 bits (316), Expect = 2e-28
 Identities = 125/395 (31%), Positives = 131/395 (33%), Gaps = 76/395 (19%)

Query: 745  QTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPT 804
            Q  P   G     PP  G   + P PPG   GP  +     S    P +         P 
Sbjct: 69   QGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGK-----PQGPPP 123

Query: 805  QSISQP--PPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLP 862
            Q  +QP  PPPP        G+P   PP                    N    P PP  P
Sbjct: 124  QGGNQPQGPPPP-------PGKPQGPPPQG-----------------GNKPQGPPPPGKP 159

Query: 863  ---------CTESSSSMPGLGMVPPP--------PPPLPGMTVPTLPSTAIPQPPPLQGT 905
                      + SS S PG    PPP        PPP PG           PQ PP QG 
Sbjct: 160  QGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGK----------PQGPPPQGG 209

Query: 906  EMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIP 965
                 PPPP    G P  PP  G         P      PPP  G     PPP PG   P
Sbjct: 210  NKPQGPPPP----GKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGK--P 263

Query: 966  LPPPLPGAGIPPPPPLPGAGIPPPP--------PLPGAGIPPPPPLPGAGIPPPPPLPGA 1017
              PP  G   P  PP PG    PPP             G P  PP  G   P  PP P  
Sbjct: 264  QGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPP-PPP 322

Query: 1018 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1077
            G P  PP  G   P  PP PG    P  P P  G          G P  PP      P  
Sbjct: 323  GKPQGPPPQGGNKPQGPPPPG---KPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQG 379

Query: 1078 PPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPP 1112
            PP P  G P  P  P AG P  PP P  G  P  P
Sbjct: 380  PPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRP 414



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 86/287 (29%), Positives = 95/287 (33%), Gaps = 30/287 (10%)

Query: 745  QTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPT 804
            Q  P   G     PP  G   + P PPG   GP  +  ++     SP             
Sbjct: 130  QGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGN 189

Query: 805  QSISQPPPPPSLLWSAGQG--QPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLP 862
            Q    PPPP        QG  +P   PP           ++   SA         PPP  
Sbjct: 190  QPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQG 249

Query: 863  CTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEML---------PPPPP 913
              +     P  G  P  PPP  G      P    PQ PP QG             P  PP
Sbjct: 250  GNQPQGPPPPPGK-PQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPP 308

Query: 914  PLPG---AGIPPPP-----PLPGAGILPLPPLPGAGIPPPPPLPGA----AIPPP----- 956
            P  G    G PPPP     P P  G  P  P P      PPP  G+    A  PP     
Sbjct: 309  PQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQG 368

Query: 957  PPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPG-AGIPPPPP 1002
            PP      P  PP P  G P  P  P AG P  PP P   G P  PP
Sbjct: 369  PPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPP 415



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 55/224 (24%), Positives = 73/224 (32%), Gaps = 29/224 (12%)

Query: 227 QGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGG-AGEAPGSPDTEQALSALSDLPESLAA 285
           QG  +P  PP    P PG   G       P GG   + P  P   Q      D   S  +
Sbjct: 63  QGGNQPQGPP----PPPGKPQGPP-----PQGGNKPQGPPPPGKPQGPPPQGDKSRSPRS 113

Query: 286 EPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDT 345
            P +PQ PP  GG       + P   P     P     P P+ G   +    P +  G  
Sbjct: 114 PPGKPQGPPPQGG-------NQPQGPPPPPGKPQG---PPPQGGNKPQGPPPPGKPQGPP 163

Query: 346 DEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAPSQ 405
            +   +     +P G P  +  P  G + PQ     P  + QGP         G P P +
Sbjct: 164 PQGDNKSRSSRSPPGKP--QGPPPQGGNQPQG-PPPPPGKPQGPPPQGGNKPQGPPPPGK 220

Query: 406 RCFKPYPLITPCYIKTTTRQLSSPNHSPSQSPNQSPRIKRRPEP 449
                 P   P      ++   SP   P   P Q     + P P
Sbjct: 221 ------PQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPP 258



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 51/189 (26%), Positives = 65/189 (34%), Gaps = 36/189 (19%)

Query: 227 QGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGG--------AGEAPGSPDTEQALSALSD 278
           QG  +P  PP    P PG   G       P GG         G+  G P    + S  S 
Sbjct: 248 QGGNQPQGPP----PPPGKPQGPP-----PQGGNKPQGPPPPGKPQGPPPQGGSKSRSSR 298

Query: 279 LPESLAAEP-----REPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEE 333
            P      P      +PQ PP P G P    P     +P     P     P P+ G    
Sbjct: 299 SPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ-GGNKPQGPPPPGKPQGPPPQGGSKSR 357

Query: 334 AAGAPV-RGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGPDAP 392
           +A +P  +  G   +EG        P+G P     P  G + PQ+    P  + QGP  P
Sbjct: 358 SARSPPGKPQGPPQQEGNN------PQGPP-----PPAGGN-PQQPQAPPAGQPQGPPRP 405

Query: 393 AAASLPGSP 401
                P  P
Sbjct: 406 PQGGRPSRP 414



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 47/186 (25%), Positives = 65/186 (34%), Gaps = 16/186 (8%)

Query: 227 QGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAE 286
           QG  +P  PP    PQ     G ++     S  A   PG P          + P+     
Sbjct: 207 QGGNKPQGPPPPGKPQGPPPQGDNK-----SQSARSPPGKPQGPPPQGG--NQPQGPPPP 259

Query: 287 PREPQQPP-----SPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRG 341
           P +PQ PP      P G P    P  P  Q  +K S SS + P    GP  +    P   
Sbjct: 260 PGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSK-SRSSRSPPGKPQGPPPQGGNQPQGP 318

Query: 342 AGDTDE-EGEEDAFEDAPRGSP--GEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLP 398
                + +G      + P+G P  G+   P     +  R    P  + QGP      +  
Sbjct: 319 PPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQ 378

Query: 399 GSPAPS 404
           G P P+
Sbjct: 379 GPPPPA 384



 Score = 41.2 bits (95), Expect = 0.009
 Identities = 43/181 (23%), Positives = 63/181 (34%), Gaps = 11/181 (6%)

Query: 270 EQALSALSDLPESLAAEP-REPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEA 328
           E++ S ++  P+    +   +PQ PPSP G P    P            P     P P+ 
Sbjct: 26  EESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQG 85

Query: 329 GPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQG 388
           G   +    P +  G    +G++     +P G P  +  P  G + PQ     P  + QG
Sbjct: 86  GNKPQGPPPPGKPQG-PPPQGDKSRSPRSPPGKP--QGPPPQGGNQPQG-PPPPPGKPQG 141

Query: 389 PDAPAAASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSSPNHSPSQSPNQSPRIKRRPE 448
           P         G P P +      P   P      +R   SP   P   P Q     + P 
Sbjct: 142 PPPQGGNKPQGPPPPGK------PQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPP 195

Query: 449 P 449
           P
Sbjct: 196 P 196



 Score = 40.0 bits (92), Expect = 0.020
 Identities = 46/198 (23%), Positives = 64/198 (32%), Gaps = 24/198 (12%)

Query: 227 QGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAE 286
           QG  +P  PP    PQ     G ++     S  +   PG P          + P+     
Sbjct: 145 QGGNKPQGPPPPGKPQGPPPQGDNK-----SRSSRSPPGKPQGPPPQGG--NQPQGPPPP 197

Query: 287 PREPQQPPSPGGLPVS--EAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGD 344
           P +PQ PP  GG        P  P   P   D+ S +A       P  +  G P +G   
Sbjct: 198 PGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSA-----RSPPGKPQGPPPQGGNQ 252

Query: 345 TD--------EEGEEDAFEDAPRGSP--GEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAA 394
                      +G      + P+G P  G+   P     +  R    P  + QGP     
Sbjct: 253 PQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGG 312

Query: 395 ASLPGSPAPSQRCFKPYP 412
               G P P  +   P P
Sbjct: 313 NQPQGPPPPPGKPQGPPP 330


>gi|4502955 type IV collagen alpha 5 isoform 1 precursor [Homo
            sapiens]
          Length = 1685

 Score =  166 bits (421), Expect = 1e-40
 Identities = 223/693 (32%), Positives = 259/693 (37%), Gaps = 200/693 (28%)

Query: 750  EEGGVLTLPPVDGLPGRP--------PCPPGAESGPQTKFCSEISLIVSPRRISVQLDSH 801
            + G  +T P   GLPG P        P  PG    P             P     + +  
Sbjct: 654  DPGQTITQPGKPGLPGNPGRDGDVGLPGDPGLPGQPGL-----------PGIPGSKGEPG 702

Query: 802  QPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPP-- 859
             P   +  PP P         G PG  PP +  T  +   E             P PP  
Sbjct: 703  IPGIGLPGPPGPKGF-----PGIPG--PPGAPGTPGRIGLE-----------GPPGPPGF 744

Query: 860  PLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPS-----TAIPQPPPLQGTEMLPPP--- 911
            P P  E   ++PG    PP PP LPG      P         P PP   G + LP P   
Sbjct: 745  PGPKGEPGFALPG----PPGPPGLPGFKGALGPKGDRGFPGPPGPPGRTGLDGLPGPKGD 800

Query: 912  -----------PPPLPGAGI---PPPPPLPG-AGILPLPPLPGAGIPPPPPLPGAAIPPP 956
                       PP LPG G+   P PP +PG  G   L  +PG    P P  PG  +P P
Sbjct: 801  VGPNGQPGPMGPPGLPGIGVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGP--PGLDVPGP 858

Query: 957  ------PPLPGAGIPLPPP----LPG----AGIP----------PPPPLPGAGIPPPPPL 992
                  P +PGA  P+ PP    LPG    +G P          PP P    GIP    +
Sbjct: 859  PGERGSPGIPGAPGPIGPPGSPGLPGKAGASGFPGTKGEMGMMGPPGPPGPLGIPGRSGV 918

Query: 993  PGA----GIPPPPPLPG----AGIPPPPPLPGAGIPPPPPLPGA----GIPPPPPLPGA- 1039
            PG     G+   P LPG     G    P LPG   P  P L G+    G P  P +PG  
Sbjct: 919  PGLKGDDGLQGQPGLPGPTGEKGSKGEPGLPGPPGPMDPNLLGSKGEKGEPGLPGIPGVS 978

Query: 1040 ------GIPPPPPLPG----AGIPPP------PPLPG-AGIPPPPPLPGA----GIP--- 1075
                  G+P  P  PG     G+P P      P LPG  G+  PP L G     G P   
Sbjct: 979  GPKGYQGLPGDPGQPGLSGQPGLPGPPGPKGNPGLPGQPGLIGPPGLKGTIGDMGFPGPQ 1038

Query: 1076 ----PPPPLPGAGIPPPPPLPG---------------AGIPPPPPLPGV-GIPPPPPLPG 1115
                PP P    G P  P LPG                G+P P   PG+ G P  P + G
Sbjct: 1039 GVEGPPGPSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGNPGIKG 1098

Query: 1116 A-GIPPPPPLPGA-GIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIP-PPPPLPGAG 1172
            + G P  P LPG  G    P LPG    P PP P+ GI  PP  P  G+P  P P+ G G
Sbjct: 1099 SVGDPGLPGLPGTPGAKGQPGLPGFPGTPGPPGPK-GISGPPGNP--GLPGEPGPVGGGG 1155

Query: 1173 IPPPPPLPGV-------GIPPP------PPLPGVGIPPPPPLPG----------AGIPPP 1209
             P  P  PG        GIP P      P  PG G P PP LPG           GIP  
Sbjct: 1156 HPGQPGPPGEKGKPGQDGIPGPAGQKGEPGQPGFGNPGPPGLPGLSGQKGDGGLPGIPGN 1215

Query: 1210 PPLPG-------MGIPPAPAPPLPP--PGTGIPPPPLLP-VSGPPLLPQVGSSTLPTPQV 1259
            P LPG        G P    PP PP  PG  +  P   P   GPP     G   LP P+ 
Sbjct: 1216 PGLPGPKGEPGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQGPP-----GRPGLPGPEG 1270

Query: 1260 CGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRP 1292
                PP LP      G+  +KG+  QP  P  P
Sbjct: 1271 ----PPGLPG---NGGIKGEKGNPGQPGLPGLP 1296



 Score =  163 bits (412), Expect = 2e-39
 Identities = 175/492 (35%), Positives = 198/492 (40%), Gaps = 92/492 (18%)

Query: 856  PSPPPLPCTESSSSMPGLGMVPPPPPPLPGMT-VPTLPST-AIPQPPPLQGTEMLPPPPP 913
            P  P LP        PG G  PP P    G+  V   P    IP P    G  +  P  P
Sbjct: 608  PGLPGLPGNIGPMGPPGFG--PPGPVGEKGIQGVAGNPGQPGIPGPKGDPGQTITQPGKP 665

Query: 914  PLPG-------AGIPPPPPLPGAGILP-------LPPLPGAGIPPPPPLPG-AAIPPPPP 958
             LPG        G+P  P LPG   LP        P +PG G+P PP   G   IP PP 
Sbjct: 666  GLPGNPGRDGDVGLPGDPGLPGQPGLPGIPGSKGEPGIPGIGLPGPPGPKGFPGIPGPPG 725

Query: 959  LPGA-------GIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPG----------AGIPPPP 1001
             PG        G P PP  PG    P   LPG   P PP LPG           G P PP
Sbjct: 726  APGTPGRIGLEGPPGPPGFPGPKGEPGFALPGP--PGPPGLPGFKGALGPKGDRGFPGPP 783

Query: 1002 PLPGA----GIPPPPPLPGAGIPP----PPPLPGAGIPPPPPLPGAGIPPPPPLPGA-GI 1052
              PG     G+P P    G    P    PP LPG G+  PP  P  GIP P   PG  GI
Sbjct: 784  GPPGRTGLDGLPGPKGDVGPNGQPGPMGPPGLPGIGVQGPPGPP--GIPGPIGQPGLHGI 841

Query: 1053 P---PPPPLPGAGIPPPPPLPGAGIPPPPPLPG-AGIPPPPPLPG----AGIPPPPPLPG 1104
            P     P  PG  +P PP   G+  P  P  PG  G P  P LPG    +G P      G
Sbjct: 842  PGEKGDPGPPGLDVPGPPGERGS--PGIPGAPGPIGPPGSPGLPGKAGASGFPGTKGEMG 899

Query: 1105 VGIPPPPPLPGAGIPPPPPLPGA----GIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGA 1160
            +  PP PP P  GIP    +PG     G+   P LPG       P    G    P LPG 
Sbjct: 900  MMGPPGPPGP-LGIPGRSGVPGLKGDDGLQGQPGLPG-------PTGEKGSKGEPGLPGP 951

Query: 1161 GIPPPPPLPGA-GIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGM-GIP 1218
              P  P L G+ G    P LPG+        PGV      P    G+P  P  PG+ G P
Sbjct: 952  PGPMDPNLLGSKGEKGEPGLPGI--------PGVS----GPKGYQGLPGDPGQPGLSGQP 999

Query: 1219 PAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGL---- 1274
              P PP P    G+P  P L +  P L   +G    P PQ  G   PP PSG+ G     
Sbjct: 1000 GLPGPPGPKGNPGLPGQPGL-IGPPGLKGTIGDMGFPGPQ--GVEGPPGPSGVPGQPGSP 1056

Query: 1275 GMNQDKGSRKQP 1286
            G+   KG +  P
Sbjct: 1057 GLPGQKGDKGDP 1068



 Score =  162 bits (410), Expect = 3e-39
 Identities = 223/705 (31%), Positives = 262/705 (37%), Gaps = 219/705 (31%)

Query: 747  SPTEEGGVLTLPPVDGLPGRPPCP--PGAESGPQTKFCSEISLIVSPRRISVQLDSHQPT 804
            +P  +G V  LP   GLPG+P  P  PG++  P                         P 
Sbjct: 670  NPGRDGDV-GLPGDPGLPGQPGLPGIPGSKGEPGI-----------------------PG 705

Query: 805  QSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPP--PLP 862
              +  PP P         G PG  PP +  T  +   E             P PP  P P
Sbjct: 706  IGLPGPPGPKGF-----PGIPG--PPGAPGTPGRIGLEGP-----------PGPPGFPGP 747

Query: 863  CTESSSSMPGLGMVPPPPPPLPGMTVPTLPS-----TAIPQPPPLQGTEMLPPP------ 911
              E   ++PG    PP PP LPG      P         P PP   G + LP P      
Sbjct: 748  KGEPGFALPG----PPGPPGLPGFKGALGPKGDRGFPGPPGPPGRTGLDGLPGPKGDVGP 803

Query: 912  --------PPPLPGAGI---PPPPPLPGA-GILPLPPLPGAGIPPPPPLPGAAIPPPPP- 958
                    PP LPG G+   P PP +PG  G   L  +PG    P PP  G  +P PP  
Sbjct: 804  NGQPGPMGPPGLPGIGVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGPP--GLDVPGPPGE 861

Query: 959  -----LPGAGIPLPPP----LPG----AGIP----------PPPPLPGAGIPPPPPLPGA 995
                 +PGA  P+ PP    LPG    +G P          PP P    GIP    +PG 
Sbjct: 862  RGSPGIPGAPGPIGPPGSPGLPGKAGASGFPGTKGEMGMMGPPGPPGPLGIPGRSGVPGL 921

Query: 996  ----GIPPPPPLPGA----GIPPPPPLPGAGIPPPPPLPGA----GIPPPPPLPGA---- 1039
                G+   P LPG     G    P LPG   P  P L G+    G P  P +PG     
Sbjct: 922  KGDDGLQGQPGLPGPTGEKGSKGEPGLPGPPGPMDPNLLGSKGEKGEPGLPGIPGVSGPK 981

Query: 1040 ---GIPPPPPLPGA----GIPPPPP------LPGA-GIPPPPPLPGA----GIPPP---- 1077
               G+P  P  PG     G+P PP       LPG  G+  PP L G     G P P    
Sbjct: 982  GYQGLPGDPGQPGLSGQPGLPGPPGPKGNPGLPGQPGLIGPPGLKGTIGDMGFPGPQGVE 1041

Query: 1078 -PPLPGA--GIPPPPPLPGA---------------GIPPPPPLPGV-GIPPPPPLPGA-- 1116
             PP P    G P  P LPG                G+P P   PG+ G P  P + G+  
Sbjct: 1042 GPPGPSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGNPGIKGSVG 1101

Query: 1117 --GIPPPPPLPGA-GIPPPPPLPGAGIPPPP-----PLPRVGIPPPP-PLPGAGIPPPPP 1167
              G+P  P  PGA G P  P  PG   PP P     P    G+P  P P+ G G P  P 
Sbjct: 1102 DPGLPGLPGTPGAKGQPGLPGFPGTPGPPGPKGISGPPGNPGLPGEPGPVGGGGHPGQPG 1161

Query: 1168 LPGA-------GIPPP------PPLPGVGIPPPPPLPGV----------GIPPPPPLPGA 1204
             PG        GIP P      P  PG G P PP LPG+          GIP  P LPG 
Sbjct: 1162 PPGEKGKPGQDGIPGPAGQKGEPGQPGFGNPGPPGLPGLSGQKGDGGLPGIPGNPGLPGP 1221

Query: 1205 ----------GI-----PPPPPLPGMGIPPA-PAPPLPPPGTGIPPPPLLPVSGPPLLPQ 1248
                      G+     PP  P P +  P   P P  PP   G+P P      GPP LP 
Sbjct: 1222 KGEPGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQGPPGRPGLPGP-----EGPPGLPG 1276

Query: 1249 VGSSTLPTPQVCGFLPPPLPSGLFGL-GMNQDKGSRKQPIEPCRP 1292
             G        + G    P   GL GL G+  D+G       P RP
Sbjct: 1277 NGG-------IKGEKGNPGQPGLPGLPGLKGDQGPPGLQGNPGRP 1314



 Score =  154 bits (388), Expect = 9e-37
 Identities = 211/636 (33%), Positives = 238/636 (37%), Gaps = 156/636 (24%)

Query: 748  PTEEG--GVLTLPPVDGLPGRPPCP--PGAESGPQTKFCSEISLIVSPRRISVQLDSHQP 803
            P E G  G+   P   G PG P  P   GA   P TK   E+ ++  P            
Sbjct: 859  PGERGSPGIPGAPGPIGPPGSPGLPGKAGASGFPGTK--GEMGMMGPPG----------- 905

Query: 804  TQSISQPPPPPSLLWSAG----------QGQPGSQPPHSISTEFQTSHEHSVSSAFKNSC 853
                  PP P  +   +G          QGQPG   P        T  + S         
Sbjct: 906  ------PPGPLGIPGRSGVPGLKGDDGLQGQPGLPGP--------TGEKGSKGEPGLPGP 951

Query: 854  NIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPT----LPSTAIPQPPPLQGTEMLP 909
              P  P L  ++     PGL       P +PG++ P     LP    P  P L G   LP
Sbjct: 952  PGPMDPNLLGSKGEKGEPGL-------PGIPGVSGPKGYQGLPGD--PGQPGLSGQPGLP 1002

Query: 910  PPPPPLPGAGIPPPPPLPGA-------GILPLPPLPGAGIPPPPP-LPGAAIPPPPPLPG 961
             PP P    G+P  P L G        G +  P   G   PP P  +PG   P  P LPG
Sbjct: 1003 GPPGPKGNPGLPGQPGLIGPPGLKGTIGDMGFPGPQGVEGPPGPSGVPGQ--PGSPGLPG 1060

Query: 962  A------------GIP-LPPPLPGAGIPPPPPLPG----AGIPPPPPLPGA-GIPPPPPL 1003
                         G+P LP P    G+P  P  PG     G P  P LPG  G    P L
Sbjct: 1061 QKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGNPGIKGSVGDPGLPGLPGTPGAKGQPGL 1120

Query: 1004 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP-PLPGAGIPPPPPLPGA-GIPPPPPLPG- 1060
            PG    P PP P  GI  PP  PG  +P  P P+ G G P  P  PG  G P    +PG 
Sbjct: 1121 PGFPGTPGPPGP-KGISGPPGNPG--LPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGP 1177

Query: 1061 AGIPPPPPLPGAGIPPPPPLPGA----------GIPPPPPLPGA-GIPPPPPLPGVGIPP 1109
            AG    P  PG G P PP LPG           GIP  P LPG  G P     PGV  PP
Sbjct: 1178 AGQKGEPGQPGFGNPGPPGLPGLSGQKGDGGLPGIPGNPGLPGPKGEPGFHGFPGVQGPP 1237

Query: 1110 PPP-LPGAGIPPPPPLPGAGIPPPPP-LPGAGIPPPPP-----LPRVGIPPPPPLPGA-- 1160
             PP  PG  +  P   PG   PP  P LPG   PP  P         G P  P LPG   
Sbjct: 1238 GPPGSPGPALEGPKGNPGPQGPPGRPGLPGPEGPPGLPGNGGIKGEKGNPGQPGLPGLPG 1297

Query: 1161 --GIPPPPPLPGA-------GIPPPPPLPGV----GIPPPPPLPG----------VGIPP 1197
              G   PP L G        G+   P LPGV    G+  P  +PG          +G P 
Sbjct: 1298 LKGDQGPPGLQGNPGRPGLNGMKGDPGLPGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPG 1357

Query: 1198 PPPLPG-----------AGIPPPPPLPGMGIPPAPAPPLPPPG-TGIPPPPLLPVSGPPL 1245
            PP LPG           AG P  P  PG+   P P  P   PG TG P  P     G   
Sbjct: 1358 PPGLPGPSGQSIIIKGDAGPPGIPGQPGLKGLPGPQGPQGLPGPTGPPGDP-----GRNG 1412

Query: 1246 LP-------QVGSSTLP-TPQVCGFLPPPLPSGLFG 1273
            LP       + G   LP  P   G   PP P GL G
Sbjct: 1413 LPGFDGAGGRKGDPGLPGQPGTRGLDGPPGPDGLQG 1448



 Score =  148 bits (373), Expect = 5e-35
 Identities = 194/577 (33%), Positives = 222/577 (38%), Gaps = 89/577 (15%)

Query: 753  GVLTLPPVDGLPGRPPCP-PGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPP 811
            GV  L   DGL G+P  P P  E G +     E  L   P  +   L   +  +     P
Sbjct: 917  GVPGLKGDDGLQGQPGLPGPTGEKGSK----GEPGLPGPPGPMDPNLLGSKGEKGEPGLP 972

Query: 812  PPPSLLWSAG-QGQPGS--QPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSS 868
              P +    G QG PG   QP  S             +        +  PP L  T    
Sbjct: 973  GIPGVSGPKGYQGLPGDPGQPGLSGQPGLPGPPGPKGNPGLPGQPGLIGPPGLKGTIGDM 1032

Query: 869  SMPGLGMVPPPPPP--LPGMT-VPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPP 925
              PG   V  PP P  +PG    P LP     +  P   +  LP  P P    G+P  P 
Sbjct: 1033 GFPGPQGVEGPPGPSGVPGQPGSPGLPGQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPG 1092

Query: 926  LPG----AGILPLPPLPGA-GIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPP- 979
             PG     G   LP LPG  G    P LPG    P PP P  GI  PP  PG  +P  P 
Sbjct: 1093 NPGIKGSVGDPGLPGLPGTPGAKGQPGLPGFPGTPGPPGP-KGISGPPGNPG--LPGEPG 1149

Query: 980  PLPGAGIPPPPPLPGA-GIPPPPPLPG-AGIPPPPPLPGAGIPPPPPLPGA--------- 1028
            P+ G G P  P  PG  G P    +PG AG    P  PG G P PP LPG          
Sbjct: 1150 PVGGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGEPGQPGFGNPGPPGLPGLSGQKGDGGL 1209

Query: 1029 -GIPPPPPLPGA-GIPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPGAGIPPPPP-LPGAG 1084
             GIP  P LPG  G P     PG   PP PP  PG  +  P   PG   PP  P LPG  
Sbjct: 1210 PGIPGNPGLPGPKGEPGFHGFPGVQGPPGPPGSPGPALEGPKGNPGPQGPPGRPGLPGPE 1269

Query: 1085 IPPPPPLPGA-----GIPPPPPLPGV----GIPPPPPLPGA-------GIPPPPPLPGA- 1127
             PP  P  G      G P  P LPG+    G   PP L G        G+   P LPG  
Sbjct: 1270 GPPGLPGNGGIKGEKGNPGQPGLPGLPGLKGDQGPPGLQGNPGRPGLNGMKGDPGLPGVP 1329

Query: 1128 ---GIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGA--------GIPPPPPLPGAGIPPP 1176
               G+  P  +PG+  P   P   +G P PP LPG         G   PP     GIP  
Sbjct: 1330 GFPGMKGPSGVPGSAGPEGEP-GLIGPPGPPGLPGPSGQSIIIKGDAGPP-----GIPGQ 1383

Query: 1177 PPLPGVGIPPPPP-LPGVGIPPPPP----LPG----------AGIPPPPPLPGMGIPPAP 1221
            P L G+  P  P  LPG   PP  P    LPG           G+P  P   G+  PP P
Sbjct: 1384 PGLKGLPGPQGPQGLPGPTGPPGDPGRNGLPGFDGAGGRKGDPGLPGQPGTRGLDGPPGP 1443

Query: 1222 APPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQ 1258
                 PPG    PP    V+   L+ +  S T   PQ
Sbjct: 1444 DGLQGPPG----PPGTSSVAHGFLITR-HSQTTDAPQ 1475



 Score =  139 bits (349), Expect = 3e-32
 Identities = 211/676 (31%), Positives = 240/676 (35%), Gaps = 160/676 (23%)

Query: 751  EGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQP 810
            E G    P ++G PG P  P G E  P  +       I  P             + I  P
Sbjct: 46   EKGERGFPGLEGHPGLPGFP-GPEGPPGPRGQKGDDGIPGP----------PGPKGIRGP 94

Query: 811  PPPPSLLWSAG----QGQPGSQPPHSISTEFQTSHEHSV--SSAFKNSCNIPSPPPLPCT 864
            P  P    + G     G  G+  P  I     T  E     S  F      P PP +P  
Sbjct: 95   PGLPGFPGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGM 154

Query: 865  ESS------SSMPGLGMVP--PPPPPLPGMTVPT-LPST-AIPQPPPLQGTEMLPPPPPP 914
            +        SS+PG    P  P PP + G+  PT +P     P PP L G    PP PP 
Sbjct: 155  KGEPGSIIMSSLPGPKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMG----PPGPPG 210

Query: 915  LPGA------------------GIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPP 956
            LPG                   G+  PP  PG       P+          LPG   PP 
Sbjct: 211  LPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQKGDQGLPGDRGPPG 270

Query: 957  PPLPGAGIPLPPPLPGA--------GIPPPPPLPGA----GIPPPPPLPG-AGIPPPPPL 1003
            PP    GI  PP  PG         G P     PG     G P  P LPG  G P  P  
Sbjct: 271  PP----GIRGPPGPPGGEKGEKGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGR 326

Query: 1004 PGA----GIPPPPPLPGAGIPPP--------------PPLPGA-------GIPPPPPLPG 1038
             G     G   PP  PG  IP P              P LPG        GI  PP LPG
Sbjct: 327  DGEKGQKGDTGPPGPPGLVIPRPGTGITIGEKGNIGLPGLPGEKGERGFPGIQGPPGLPG 386

Query: 1039 AGIPPPPPLPGAGIPPPPPLPGA-GIPPPPPLPGAGIPPPPPL---PGA-GIPPPPPLPG 1093
                 PP     G P PP  PG  G       PG  IP PP L   PGA G+P PP   G
Sbjct: 387  -----PPGAAVMGPPGPPGFPGERGQKGDEGPPGISIPGPPGLDGQPGAPGLPGPPGPAG 441

Query: 1094 AGIPPPPPLPGVGIPPPPPLPG-----------------------AGIPPPPPLPGA-GI 1129
              IPP   +   G P PP  PG                        GI  PP  PG  G+
Sbjct: 442  PHIPPSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPGQPGLPGL 501

Query: 1130 PPPPP---LPG-------AGIPPPPPLPRV-GIPPPPPLPGAGIPPPPPL--PGA----- 1171
            P PP     PG       AG   P  LP + G P  P  PG+   P   L  PG      
Sbjct: 502  PGPPGSLGFPGQKGEKGQAGATGPKGLPGIPGAPGAPGFPGSKGEPGDILTFPGMKGDKG 561

Query: 1172 --GIPPPPPLPGV-GIPPPPPLPGVGIPPPPPLPGA----GIPPPPPLPGMGIPPAPAPP 1224
              G P  P LPG+ G P    LPG  +P P   PG     G   PP  PG+   P    P
Sbjct: 562  ELGSPGAPGLPGLPGTPGQDGLPG--LPGPKGEPGGITFKGERGPPGNPGLPGLPGNIGP 619

Query: 1225 LPPPGTGIPPP----PLLPVSGPPLLPQV-GSSTLPTPQVCGFLPPPLPS--GLFG-LGM 1276
            + PPG G P P     +  V+G P  P + G    P   +     P LP   G  G +G+
Sbjct: 620  MGPPGFGPPGPVGEKGIQGVAGNPGQPGIPGPKGDPGQTITQPGKPGLPGNPGRDGDVGL 679

Query: 1277 NQDKGSRKQPIEPCRP 1292
              D G   QP  P  P
Sbjct: 680  PGDPGLPGQPGLPGIP 695



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 71/256 (27%), Positives = 90/256 (35%), Gaps = 46/256 (17%)

Query: 748  PTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSI 807
            P  E G    P V G PG P  P  A  GP+                  Q    +P   +
Sbjct: 1221 PKGEPGFHGFPGVQGPPGPPGSPGPALEGPKGN-------------PGPQGPPGRP--GL 1265

Query: 808  SQPPPPPSLLWSAG-------QGQPGSQPPHSISTE-----FQTSHEHSVSSAFKNSCNI 855
              P  PP L  + G        GQPG      +  +      Q +      +  K    +
Sbjct: 1266 PGPEGPPGLPGNGGIKGEKGNPGQPGLPGLPGLKGDQGPPGLQGNPGRPGLNGMKGDPGL 1325

Query: 856  PSPPPLPCTESSSSMPGL-------GMVPPPPPP-LPGMTVPTLPSTAIPQPPPLQGTEM 907
            P  P  P  +  S +PG        G++ PP PP LPG +  ++       PP + G   
Sbjct: 1326 PGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGPPGLPGPSGQSIIIKGDAGPPGIPGQPG 1385

Query: 908  LPPPPPPLPGAGIPPPPPLPG-AGILPLPPLPGA-GIPPPPPLPGAAIPPPPPLPGA-GI 964
            L   P P    G+P P   PG  G   LP   GA G    P LPG         PG  G+
Sbjct: 1386 LKGLPGPQGPQGLPGPTGPPGDPGRNGLPGFDGAGGRKGDPGLPGQ--------PGTRGL 1437

Query: 965  PLPPPLPGAGIPPPPP 980
              PP   G   PP PP
Sbjct: 1438 DGPPGPDGLQGPPGPP 1453



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 49/159 (30%), Positives = 57/159 (35%), Gaps = 18/159 (11%)

Query: 255  GPSGGAGEAPGSP----------DTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEA 304
            GPSG  G+ PGSP          D   +   L  LP     EP  P  P +PG       
Sbjct: 1045 GPSGVPGQ-PGSPGLPGQKGDKGDPGISSIGLPGLPGP-KGEPGLPGYPGNPGIKGSVGD 1102

Query: 305  PSLPA--AQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGE-EDAFEDAPRGS 361
            P LP     P AK  P    FP     PG +    P    G   E G           G 
Sbjct: 1103 PGLPGLPGTPGAKGQPGLPGFPGTPGPPGPKGISGPPGNPGLPGEPGPVGGGGHPGQPGP 1162

Query: 362  PGEEWAPEVGEDA-PQRLGEEPEEEAQGPDAPAAASLPG 399
            PGE+  P  G+D  P   G++ E    G   P    LPG
Sbjct: 1163 PGEKGKP--GQDGIPGPAGQKGEPGQPGFGNPGPPGLPG 1199



 Score = 39.3 bits (90), Expect = 0.033
 Identities = 58/241 (24%), Positives = 78/241 (32%), Gaps = 45/241 (18%)

Query: 227 QGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTE-----QALSALSDLPE 281
           +G   P  PP  V P+PG  +      +G  G  G  PG P  +       +     LP 
Sbjct: 333 KGDTGPPGPPGLVIPRPGTGI-----TIGEKGNIG-LPGLPGEKGERGFPGIQGPPGLPG 386

Query: 282 SLAAEPREPQQPP------------SPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAG 329
              A    P  PP             P G+ +   P L   QP A   P       P   
Sbjct: 387 PPGAAVMGPPGPPGFPGERGQKGDEGPPGISIPGPPGLD-GQPGAPGLPGPPGPAGPHIP 445

Query: 330 PGEE----AAGAPVRGAGDTDEEGEEDAFED--------------APRGSPGEEW--APE 369
           P +E        P    GD   +GE+    D               P G PG      P 
Sbjct: 446 PSDEICEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPGQPGLPGLPGPP 505

Query: 370 VGEDAPQRLGEEPEEEAQGPDA-PAAASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSS 428
                P + GE+ +  A GP   P     PG+P       +P  ++T   +K    +L S
Sbjct: 506 GSLGFPGQKGEKGQAGATGPKGLPGIPGAPGAPGFPGSKGEPGDILTFPGMKGDKGELGS 565

Query: 429 P 429
           P
Sbjct: 566 P 566



 Score = 36.2 bits (82), Expect = 0.28
 Identities = 47/181 (25%), Positives = 61/181 (33%), Gaps = 38/181 (20%)

Query: 236 PTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPS 295
           P  +  QPGA       L GP G AG  P  P +++              EP  P  P S
Sbjct: 421 PPGLDGQPGA-----PGLPGPPGPAG--PHIPPSDEI------------CEPGPPGPPGS 461

Query: 296 PGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEE-DAF 354
           PG   +     +   +     +   T    P   PG      P    G   ++GE+  A 
Sbjct: 462 PGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPGQPGLPGLPGPPGSLGFPGQKGEKGQAG 521

Query: 355 EDAPRGSPGEEWAPEVGEDAPQRLGEEPEE--------------EAQGPDAPAAASLPGS 400
              P+G PG   AP     AP   G + E               E   P AP    LPG+
Sbjct: 522 ATGPKGLPGIPGAP----GAPGFPGSKGEPGDILTFPGMKGDKGELGSPGAPGLPGLPGT 577

Query: 401 P 401
           P
Sbjct: 578 P 578



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 44/176 (25%), Positives = 60/176 (34%), Gaps = 17/176 (9%)

Query: 231  EPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEA--PGSPDTEQALSALSDLPESLAAEPR 288
            +P  P   +S QPG        L GP G  G    PG P           + +     P+
Sbjct: 989  DPGQP--GLSGQPG--------LPGPPGPKGNPGLPGQPGLIGPPGLKGTIGDMGFPGPQ 1038

Query: 289  EPQQPPSPGGLPVSE-APSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDE 347
              + PP P G+P    +P LP  Q   K  P  ++   P     +   G P        +
Sbjct: 1039 GVEGPPGPSGVPGQPGSPGLP-GQKGDKGDPGISSIGLPGLPGPKGEPGLPGYPGNPGIK 1097

Query: 348  EGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAP 403
                D       G+PG +  P +    P   G    +   GP  P    LPG P P
Sbjct: 1098 GSVGDPGLPGLPGTPGAKGQPGL-PGFPGTPGPPGPKGISGP--PGNPGLPGEPGP 1150



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 32/125 (25%), Positives = 41/125 (32%), Gaps = 31/125 (24%)

Query: 291  QQPPSPGGLPVSEAPSL--PAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEE 348
            Q PP P G P    P+L  P   P  +  P     P PE  PG    G  ++G       
Sbjct: 1234 QGPPGPPGSP---GPALEGPKGNPGPQGPPGRPGLPGPEGPPGLPGNGG-IKG------- 1282

Query: 349  GEEDAFEDAPRGSPGEEWAPEV----GEDAPQRLGEEPEEEAQG-----PDAPAAASLPG 399
                      +G+PG+   P +    G+  P  L   P           P  P     PG
Sbjct: 1283 ---------EKGNPGQPGLPGLPGLKGDQGPPGLQGNPGRPGLNGMKGDPGLPGVPGFPG 1333

Query: 400  SPAPS 404
               PS
Sbjct: 1334 MKGPS 1338



 Score = 31.2 bits (69), Expect = 9.1
 Identities = 49/177 (27%), Positives = 54/177 (30%), Gaps = 25/177 (14%)

Query: 232  PAAPPTAVSPQPGAFLGLDRF--LLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPRE 289
            P  P     P P    G   F  + GP G     PGSP    AL      P         
Sbjct: 1210 PGIPGNPGLPGPKGEPGFHGFPGVQGPPG----PPGSPGP--ALEGPKGNPG-------- 1255

Query: 290  PQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEG 349
            PQ PP   GLP  E P         K    +   P     PG +    P    G+    G
Sbjct: 1256 PQGPPGRPGLPGPEGPPGLPGNGGIKGEKGNPGQPGLPGLPGLKGDQGPPGLQGNPGRPG 1315

Query: 350  EEDAFEDAPRGSPGEEWAPEV--GEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAPS 404
                  D   G PG    P +      P   G E E    GP  P     PG P PS
Sbjct: 1316 LNGMKGDP--GLPGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGP-----PGLPGPS 1365


>gi|32895368 alpha 1 type VIII collagen precursor [Homo sapiens]
          Length = 744

 Score =  164 bits (415), Expect = 7e-40
 Identities = 169/486 (34%), Positives = 201/486 (41%), Gaps = 89/486 (18%)

Query: 877  PPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPP------------PP 924
            PP PP LPG  +P +     PQ  P  G   +P  P      G+P             P 
Sbjct: 131  PPGPPGLPGHGIPGIKGKPGPQGYPGVGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPM 190

Query: 925  PLPGAGILPLPP-LPGAGIPPPPPLPGAAIPP----PPPLPGA-GIPLPPPLPGAGIPPP 978
             +PG    P P  LPG G P  P LPG   P     P  LPG  G+  P    G G+P  
Sbjct: 191  GIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGA 250

Query: 979  PPLPGA----GIPPPPPLPGAGIP-------PPPPLPGAGIPPPP----PLPGAGIPPPP 1023
            P + G     G P P  LPG G P       P  PL   G P  P    P+   G+  PP
Sbjct: 251  PGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPP 310

Query: 1024 PLPGAG------IPPPPPLPGA-------GIPPPPPLPGAGIP--PPPP-------LPGA 1061
             +PG G      IP  P  PG        G+P PP LPG G P  P P        +PGA
Sbjct: 311  GIPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVPGA 370

Query: 1062 ----GIPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPGA-GIPPPPPLPGVGIPPPPPLPG 1115
                G   P   PG G PP  P LPG  IP P   PGA G P P    G+  P  PP P 
Sbjct: 371  LGPRGEKGPIGAPGIGGPPGEPGLPG--IPGPMGPPGAIGFPGPKGEGGIVGPQGPPGPK 428

Query: 1116 A-----GIPPPPPLPG-AGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGA-GIPPPPPL 1168
                  G P  P   G  G P    LPG  I P     + G+P  P +PG  G    P +
Sbjct: 429  GEPGLQGFPGKPGFLGEVGPPGMRGLPGP-IGPKGEAGQKGVPGLPGVPGLLGPKGEPGI 487

Query: 1169 PG-AGIPPPPPLPGVGIPP----PPPLPGV----GIPPPPPLPGAGIPPPPPLPGMGIPP 1219
            PG  G+  PP +PG+G P     PP +PG     G+P PP  PG G    P + G+  PP
Sbjct: 488  PGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIG---KPGVAGLHGPP 544

Query: 1220 APAPPLPPPGT-GIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGLGMNQ 1278
                 L P G  G+P PP     GPP  P   +   PTP   G   P +  G+ G+    
Sbjct: 545  GKPGALGPQGQPGLPGPP-----GPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPH 599

Query: 1279 DKGSRK 1284
              G++K
Sbjct: 600  AYGAKK 605



 Score =  149 bits (375), Expect = 3e-35
 Identities = 170/506 (33%), Positives = 195/506 (38%), Gaps = 125/506 (24%)

Query: 872  GLGMVPPPPPPLPGMTVPTLPSTAIP-QPPPLQGTEMLPPPPPPLPGA---GIPPPPPLP 927
            GL M    P    G   P LP      QP P  G E +P     +P A   G   P   P
Sbjct: 67   GLAMGKEMPHLQYGKEYPHLPQYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEP 126

Query: 928  GAGILPLPP-LPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGA-- 984
            G    P PP LPG GIP     PG     P   PG G P  P +PG   P    +PGA  
Sbjct: 127  GPRGPPGPPGLPGHGIPGIKGKPG-----PQGYPGVGKPGMPGMPGK--PGAMGMPGAKG 179

Query: 985  -----GIPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPGAGIPP----PPPLPGA-GIPPP 1033
                 G   P  +PG   PP P  LPG G P  P LPG   P     P  LPG  G+  P
Sbjct: 180  EIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGP 239

Query: 1034 PPLPGAGIPPPPPLPGA----GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1089
                G G+P  P + G     G P P  LPG G P     PG    P  PL   G P  P
Sbjct: 240  KGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPG----PQGPLGKPGAPGEP 295

Query: 1090 ----PLPGAGIPPPPPLPGV------GIPPPPPLPGA-------GIPPPPPLPGAGIPPP 1132
                P+   G+  PP +PG+      GIP  P  PG        G+P PP LPG G P  
Sbjct: 296  GPQGPIGVPGVQGPPGIPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGF 355

Query: 1133 P----------------------PLPGAGIPPPPPLPRV-GIPPPPPLPGA-GIP----- 1163
            P                      P+   GI  PP  P + GIP P   PGA G P     
Sbjct: 356  PGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGE 415

Query: 1164 --------PPPPLPGAGIPPPPPLPGV----------GIPPP------------PPLPGV 1193
                    PP P    G+   P  PG           G+P P            P LPGV
Sbjct: 416  GGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGV 475

Query: 1194 ----GIPPPPPLPG-AGIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLP-VSGPPLLP 1247
                G    P +PG  G+  PP +PG+G    P+ P+ PP  GIP P   P + GPP  P
Sbjct: 476  PGLLGPKGEPGIPGDQGLQGPPGIPGIG---GPSGPIGPP--GIPGPKGEPGLPGPPGFP 530

Query: 1248 QVGSSTLPTPQVCGFLPPPLPSGLFG 1273
             +G      P V G   PP   G  G
Sbjct: 531  GIGK-----PGVAGLHGPPGKPGALG 551



 Score =  138 bits (348), Expect = 4e-32
 Identities = 169/514 (32%), Positives = 197/514 (38%), Gaps = 117/514 (22%)

Query: 856  PSPPPLPCTESSSSMPG-------------LGMVPPPPPP----LPGMTVPTLPST-AIP 897
            P  P +P    +  MPG             +G+  P  PP    LPG+  P  P     P
Sbjct: 160  PGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQP 219

Query: 898  QPPPLQGTEMLPPP-----PPPLPGAGIPPPPPLPGAGILPLPP----LPGAGIPPPPPL 948
             P   +G + LP P     P    G G+P  P + G   +  PP    LPG G P     
Sbjct: 220  GPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGF 279

Query: 949  PGAAIPPPPPLPGAGIPLPP----PLPGAGIPPPPPLPGAG------IPPPPPLPGA--- 995
            PG    P  PL   G P  P    P+   G+  PP +PG G      IP  P  PG    
Sbjct: 280  PG----PQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGIGKPGQDGIPGQPGFPGGKGE 335

Query: 996  ----GIPPPPPLPGAGIP--PPPP-------LPGA----GIPPPPPLPGAGIPPPPP-LP 1037
                G+P PP LPG G P  P P        +PGA    G   P   PG G PP  P LP
Sbjct: 336  QGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLP 395

Query: 1038 GAGIPPPPPLPGA-GIPPPPPLPGAGIPPPPPLPGA-----GIPPPPPLPG-AGIPPPPP 1090
            G  IP P   PGA G P P    G   P  PP P       G P  P   G  G P    
Sbjct: 396  G--IPGPMGPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRG 453

Query: 1091 LPGA----------GIPPPPPLPGV-GIPPPPPLPG-AGIPPPPPLPGAGIPP----PPP 1134
            LPG           G+P  P +PG+ G    P +PG  G+  PP +PG G P     PP 
Sbjct: 454  LPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPG 513

Query: 1135 LPGA----GIPPPPPLPRVGIPP------PPPLPGA----------GIPPPP--PLPGAG 1172
            +PG     G+P PP  P +G P       PP  PGA          G P PP  P P A 
Sbjct: 514  IPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAV 573

Query: 1173 IPPPPPLPGVGIPPPPPLPGVGIP--PPPPLPGA--GIPPPPPLPGMGIPPAPAPPLPPP 1228
            +PP PP  G  +P      G+GI    PP   GA  G    P             P PP 
Sbjct: 574  MPPTPPPQGEYLPD----MGLGIDGVKPPHAYGAKKGKNGGPAYEMPAFTAELTAPFPPV 629

Query: 1229 GTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGF 1262
            G  +    LL        PQ G  T   P V  F
Sbjct: 630  GAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYF 663



 Score =  130 bits (328), Expect = 8e-30
 Identities = 143/413 (34%), Positives = 164/413 (39%), Gaps = 81/413 (19%)

Query: 855  IPSPPPL--PCTESSSSMPGLGMV--------PPPPPPLPGMTVPTLPSTAIPQPP-PLQ 903
            +P P  L  P  +    MPG   V        PP P  LPG+  P +     PQ P    
Sbjct: 230  LPGPQGLRGPKGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKP 289

Query: 904  GTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGA-GIPPPPPLPGA-------AIPP 955
            G    P P  P+   G+  PP +PG G       PG  GIP  P  PG         +P 
Sbjct: 290  GAPGEPGPQGPIGVPGVQGPPGIPGIG------KPGQDGIPGQPGFPGGKGEQGLPGLPG 343

Query: 956  PPPLPGAGIP-LPPP--------LPGA----GIPPPPPLPGAGIPPPPP-LPGAGIPPPP 1001
            PP LPG G P  P P        +PGA    G   P   PG G PP  P LPG  IP P 
Sbjct: 344  PPGLPGIGKPGFPGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPG--IPGPM 401

Query: 1002 PLPGA-GIPPPPPLPGAGIPPPPPLPGA-----GIPPPPPLPG-AGIPPPPPLPGA---- 1050
              PGA G P P    G   P  PP P       G P  P   G  G P    LPG     
Sbjct: 402  GPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPK 461

Query: 1051 ------GIPPPPPLPGA-GIPPPPPLPG-AGIPPPPPLPGAGIPP----PPPLPGA---- 1094
                  G+P  P +PG  G    P +PG  G+  PP +PG G P     PP +PG     
Sbjct: 462  GEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEP 521

Query: 1095 GIPPPPPLPGVGIPP------PPPLPGA-GIPPPPPLPGAGIPPPPPLPG-AGIPPPPPL 1146
            G+P PP  PG+G P       PP  PGA G    P LPG   P PP  PG   + PP P 
Sbjct: 522  GLPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGP--PGPPGPPGPPAVMPPTPP 579

Query: 1147 PRVGIPPPPPLPGAGIPPPPPL---PGAGIPPPPPLPGVGIPPPPPLPGVGIP 1196
            P+    P   L   G+ PP       G    P   +P        P P VG P
Sbjct: 580  PQGEYLPDMGLGIDGVKPPHAYGAKKGKNGGPAYEMPAFTAELTAPFPPVGAP 632



 Score =  103 bits (256), Expect = 2e-21
 Identities = 121/380 (31%), Positives = 145/380 (38%), Gaps = 64/380 (16%)

Query: 810  PPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSS 869
            P P   L      G+PG Q P  +           +    ++   IP  P  P  +    
Sbjct: 280  PGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGIGKPGQDG--IPGQPGFPGGKGEQG 337

Query: 870  MPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPP--------LPGAGIP 921
            +PGL    P PP LPG+  P  P      P   +G   +P    P         PG G P
Sbjct: 338  LPGL----PGPPGLPGIGKPGFPG-----PKGDRGMGGVPGALGPRGEKGPIGAPGIGGP 388

Query: 922  PPPP-LPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGA-----GIPLPPPLPG-AG 974
            P  P LPG    P+ P    G P P    G   P  PP P       G P  P   G  G
Sbjct: 389  PGEPGLPGIPG-PMGPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVG 447

Query: 975  IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA-GIPPPPPLPG-AGIPPPPPLPGAGIPP 1032
             P    LPG  I P       G+P  P +PG  G    P +PG  G+  PP +PG G P 
Sbjct: 448  PPGMRGLPGP-IGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPS 506

Query: 1033 ----PPPLPGA----GIPPPPPLPG------AGIPPPPPLPGA-GIPPPPPLPGAGIPPP 1077
                PP +PG     G+P PP  PG      AG+  PP  PGA G    P LPG   P P
Sbjct: 507  GPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGP--PGP 564

Query: 1078 --PPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPL---PGAGIPPP 1132
              PP P A +PP PP  G  +P      G+GI         G+ PP       G    P 
Sbjct: 565  PGPPGPPAVMPPTPPPQGEYLPD----MGLGID--------GVKPPHAYGAKKGKNGGPA 612

Query: 1133 PPLPGAGIPPPPPLPRVGIP 1152
              +P        P P VG P
Sbjct: 613  YEMPAFTAELTAPFPPVGAP 632



 Score = 37.4 bits (85), Expect = 0.13
 Identities = 60/229 (26%), Positives = 83/229 (36%), Gaps = 28/229 (12%)

Query: 196 LSDIQQAIRLQQQQ--QQQLQLQLQQQQQQQQLQGAEEPAAPPTAVSPQPGAFLGLDRFL 253
           + +IQ A R+ ++   ++  ++ L   + +Q  +G   P  PP      PG  +   +  
Sbjct: 90  MKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGPPGPPG-LPGHGIPGIKGK 148

Query: 254 LGPSG--GAGEA-----PGSPDTEQALSALSDLPESLAAEPRE---PQQPPSPGGLPVSE 303
            GP G  G G+      PG P       A  ++ +     P     PQ PP P GLP   
Sbjct: 149 PGPQGYPGVGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIG 208

Query: 304 APSLPA--AQPAAKDSPSSTAFPFPEA--GP-GEEAAGAPVRGAGDTDEEGEEDAF-EDA 357
            P  P    QP  K        P P+   GP G++  G P    G    +G         
Sbjct: 209 KPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMP----GAPGVKGPPGMHGPPG 264

Query: 358 PRGSPGEEWAPEVGEDAPQ----RLGEEPEEEAQGP-DAPAAASLPGSP 401
           P G PG       G   PQ    + G   E   QGP   P     PG P
Sbjct: 265 PVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIP 313



 Score = 35.8 bits (81), Expect = 0.37
 Identities = 59/252 (23%), Positives = 77/252 (30%), Gaps = 21/252 (8%)

Query: 255 GPSG--GAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAPSLPAAQP 312
           GP G  G G  PG P        +   P      P     P   GG+   + P  P  +P
Sbjct: 378 GPIGAPGIGGPPGEPGLPGIPGPMG--PPGAIGFPG----PKGEGGIVGPQGPPGPKGEP 431

Query: 313 AAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAP--RGSPGEEWAPEV 370
             +  P    F      PG      P+   G+  ++G        P   G  GE   P  
Sbjct: 432 GLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKG-VPGLPGVPGLLGPKGEPGIP-- 488

Query: 371 GEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSSPN 430
           G+   Q  G        GP  P     PG P P      P P   P   K     L  P 
Sbjct: 489 GDQGLQ--GPPGIPGIGGPSGPIGP--PGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPP 544

Query: 431 HSP-SQSPNQSPRIKRRPEPSLSRGSRTALASVAAPAKKHRADGGLAAGLSRSADWTEEL 489
             P +  P   P +   P P    G    +     P  ++  D GL              
Sbjct: 545 GKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGID---GVKPPHAY 601

Query: 490 GARTPRVGGSAH 501
           GA+  + GG A+
Sbjct: 602 GAKKGKNGGPAY 613


>gi|17738302 alpha 1 type VIII collagen precursor [Homo sapiens]
          Length = 744

 Score =  164 bits (415), Expect = 7e-40
 Identities = 169/486 (34%), Positives = 201/486 (41%), Gaps = 89/486 (18%)

Query: 877  PPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPP------------PP 924
            PP PP LPG  +P +     PQ  P  G   +P  P      G+P             P 
Sbjct: 131  PPGPPGLPGHGIPGIKGKPGPQGYPGVGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPM 190

Query: 925  PLPGAGILPLPP-LPGAGIPPPPPLPGAAIPP----PPPLPGA-GIPLPPPLPGAGIPPP 978
             +PG    P P  LPG G P  P LPG   P     P  LPG  G+  P    G G+P  
Sbjct: 191  GIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGA 250

Query: 979  PPLPGA----GIPPPPPLPGAGIP-------PPPPLPGAGIPPPP----PLPGAGIPPPP 1023
            P + G     G P P  LPG G P       P  PL   G P  P    P+   G+  PP
Sbjct: 251  PGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPP 310

Query: 1024 PLPGAG------IPPPPPLPGA-------GIPPPPPLPGAGIP--PPPP-------LPGA 1061
             +PG G      IP  P  PG        G+P PP LPG G P  P P        +PGA
Sbjct: 311  GIPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVPGA 370

Query: 1062 ----GIPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPGA-GIPPPPPLPGVGIPPPPPLPG 1115
                G   P   PG G PP  P LPG  IP P   PGA G P P    G+  P  PP P 
Sbjct: 371  LGPRGEKGPIGAPGIGGPPGEPGLPG--IPGPMGPPGAIGFPGPKGEGGIVGPQGPPGPK 428

Query: 1116 A-----GIPPPPPLPG-AGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGA-GIPPPPPL 1168
                  G P  P   G  G P    LPG  I P     + G+P  P +PG  G    P +
Sbjct: 429  GEPGLQGFPGKPGFLGEVGPPGMRGLPGP-IGPKGEAGQKGVPGLPGVPGLLGPKGEPGI 487

Query: 1169 PG-AGIPPPPPLPGVGIPP----PPPLPGV----GIPPPPPLPGAGIPPPPPLPGMGIPP 1219
            PG  G+  PP +PG+G P     PP +PG     G+P PP  PG G    P + G+  PP
Sbjct: 488  PGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIG---KPGVAGLHGPP 544

Query: 1220 APAPPLPPPGT-GIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGLGMNQ 1278
                 L P G  G+P PP     GPP  P   +   PTP   G   P +  G+ G+    
Sbjct: 545  GKPGALGPQGQPGLPGPP-----GPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPH 599

Query: 1279 DKGSRK 1284
              G++K
Sbjct: 600  AYGAKK 605



 Score =  149 bits (375), Expect = 3e-35
 Identities = 170/506 (33%), Positives = 195/506 (38%), Gaps = 125/506 (24%)

Query: 872  GLGMVPPPPPPLPGMTVPTLPSTAIP-QPPPLQGTEMLPPPPPPLPGA---GIPPPPPLP 927
            GL M    P    G   P LP      QP P  G E +P     +P A   G   P   P
Sbjct: 67   GLAMGKEMPHLQYGKEYPHLPQYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEP 126

Query: 928  GAGILPLPP-LPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGA-- 984
            G    P PP LPG GIP     PG     P   PG G P  P +PG   P    +PGA  
Sbjct: 127  GPRGPPGPPGLPGHGIPGIKGKPG-----PQGYPGVGKPGMPGMPGK--PGAMGMPGAKG 179

Query: 985  -----GIPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPGAGIPP----PPPLPGA-GIPPP 1033
                 G   P  +PG   PP P  LPG G P  P LPG   P     P  LPG  G+  P
Sbjct: 180  EIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGP 239

Query: 1034 PPLPGAGIPPPPPLPGA----GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1089
                G G+P  P + G     G P P  LPG G P     PG    P  PL   G P  P
Sbjct: 240  KGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPG----PQGPLGKPGAPGEP 295

Query: 1090 ----PLPGAGIPPPPPLPGV------GIPPPPPLPGA-------GIPPPPPLPGAGIPPP 1132
                P+   G+  PP +PG+      GIP  P  PG        G+P PP LPG G P  
Sbjct: 296  GPQGPIGVPGVQGPPGIPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGF 355

Query: 1133 P----------------------PLPGAGIPPPPPLPRV-GIPPPPPLPGA-GIP----- 1163
            P                      P+   GI  PP  P + GIP P   PGA G P     
Sbjct: 356  PGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGE 415

Query: 1164 --------PPPPLPGAGIPPPPPLPGV----------GIPPP------------PPLPGV 1193
                    PP P    G+   P  PG           G+P P            P LPGV
Sbjct: 416  GGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGV 475

Query: 1194 ----GIPPPPPLPG-AGIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLP-VSGPPLLP 1247
                G    P +PG  G+  PP +PG+G    P+ P+ PP  GIP P   P + GPP  P
Sbjct: 476  PGLLGPKGEPGIPGDQGLQGPPGIPGIG---GPSGPIGPP--GIPGPKGEPGLPGPPGFP 530

Query: 1248 QVGSSTLPTPQVCGFLPPPLPSGLFG 1273
             +G      P V G   PP   G  G
Sbjct: 531  GIGK-----PGVAGLHGPPGKPGALG 551



 Score =  138 bits (348), Expect = 4e-32
 Identities = 169/514 (32%), Positives = 197/514 (38%), Gaps = 117/514 (22%)

Query: 856  PSPPPLPCTESSSSMPG-------------LGMVPPPPPP----LPGMTVPTLPST-AIP 897
            P  P +P    +  MPG             +G+  P  PP    LPG+  P  P     P
Sbjct: 160  PGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQP 219

Query: 898  QPPPLQGTEMLPPP-----PPPLPGAGIPPPPPLPGAGILPLPP----LPGAGIPPPPPL 948
             P   +G + LP P     P    G G+P  P + G   +  PP    LPG G P     
Sbjct: 220  GPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGF 279

Query: 949  PGAAIPPPPPLPGAGIPLPP----PLPGAGIPPPPPLPGAG------IPPPPPLPGA--- 995
            PG    P  PL   G P  P    P+   G+  PP +PG G      IP  P  PG    
Sbjct: 280  PG----PQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGIGKPGQDGIPGQPGFPGGKGE 335

Query: 996  ----GIPPPPPLPGAGIP--PPPP-------LPGA----GIPPPPPLPGAGIPPPPP-LP 1037
                G+P PP LPG G P  P P        +PGA    G   P   PG G PP  P LP
Sbjct: 336  QGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLP 395

Query: 1038 GAGIPPPPPLPGA-GIPPPPPLPGAGIPPPPPLPGA-----GIPPPPPLPG-AGIPPPPP 1090
            G  IP P   PGA G P P    G   P  PP P       G P  P   G  G P    
Sbjct: 396  G--IPGPMGPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRG 453

Query: 1091 LPGA----------GIPPPPPLPGV-GIPPPPPLPG-AGIPPPPPLPGAGIPP----PPP 1134
            LPG           G+P  P +PG+ G    P +PG  G+  PP +PG G P     PP 
Sbjct: 454  LPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPG 513

Query: 1135 LPGA----GIPPPPPLPRVGIPP------PPPLPGA----------GIPPPP--PLPGAG 1172
            +PG     G+P PP  P +G P       PP  PGA          G P PP  P P A 
Sbjct: 514  IPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAV 573

Query: 1173 IPPPPPLPGVGIPPPPPLPGVGIP--PPPPLPGA--GIPPPPPLPGMGIPPAPAPPLPPP 1228
            +PP PP  G  +P      G+GI    PP   GA  G    P             P PP 
Sbjct: 574  MPPTPPPQGEYLPD----MGLGIDGVKPPHAYGAKKGKNGGPAYEMPAFTAELTAPFPPV 629

Query: 1229 GTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGF 1262
            G  +    LL        PQ G  T   P V  F
Sbjct: 630  GAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYF 663



 Score =  130 bits (328), Expect = 8e-30
 Identities = 143/413 (34%), Positives = 164/413 (39%), Gaps = 81/413 (19%)

Query: 855  IPSPPPL--PCTESSSSMPGLGMV--------PPPPPPLPGMTVPTLPSTAIPQPP-PLQ 903
            +P P  L  P  +    MPG   V        PP P  LPG+  P +     PQ P    
Sbjct: 230  LPGPQGLRGPKGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKP 289

Query: 904  GTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGA-GIPPPPPLPGA-------AIPP 955
            G    P P  P+   G+  PP +PG G       PG  GIP  P  PG         +P 
Sbjct: 290  GAPGEPGPQGPIGVPGVQGPPGIPGIG------KPGQDGIPGQPGFPGGKGEQGLPGLPG 343

Query: 956  PPPLPGAGIP-LPPP--------LPGA----GIPPPPPLPGAGIPPPPP-LPGAGIPPPP 1001
            PP LPG G P  P P        +PGA    G   P   PG G PP  P LPG  IP P 
Sbjct: 344  PPGLPGIGKPGFPGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPG--IPGPM 401

Query: 1002 PLPGA-GIPPPPPLPGAGIPPPPPLPGA-----GIPPPPPLPG-AGIPPPPPLPGA---- 1050
              PGA G P P    G   P  PP P       G P  P   G  G P    LPG     
Sbjct: 402  GPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPK 461

Query: 1051 ------GIPPPPPLPGA-GIPPPPPLPG-AGIPPPPPLPGAGIPP----PPPLPGA---- 1094
                  G+P  P +PG  G    P +PG  G+  PP +PG G P     PP +PG     
Sbjct: 462  GEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEP 521

Query: 1095 GIPPPPPLPGVGIPP------PPPLPGA-GIPPPPPLPGAGIPPPPPLPG-AGIPPPPPL 1146
            G+P PP  PG+G P       PP  PGA G    P LPG   P PP  PG   + PP P 
Sbjct: 522  GLPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGP--PGPPGPPGPPAVMPPTPP 579

Query: 1147 PRVGIPPPPPLPGAGIPPPPPL---PGAGIPPPPPLPGVGIPPPPPLPGVGIP 1196
            P+    P   L   G+ PP       G    P   +P        P P VG P
Sbjct: 580  PQGEYLPDMGLGIDGVKPPHAYGAKKGKNGGPAYEMPAFTAELTAPFPPVGAP 632



 Score =  103 bits (256), Expect = 2e-21
 Identities = 121/380 (31%), Positives = 145/380 (38%), Gaps = 64/380 (16%)

Query: 810  PPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSS 869
            P P   L      G+PG Q P  +           +    ++   IP  P  P  +    
Sbjct: 280  PGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGIGKPGQDG--IPGQPGFPGGKGEQG 337

Query: 870  MPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPP--------LPGAGIP 921
            +PGL    P PP LPG+  P  P      P   +G   +P    P         PG G P
Sbjct: 338  LPGL----PGPPGLPGIGKPGFPG-----PKGDRGMGGVPGALGPRGEKGPIGAPGIGGP 388

Query: 922  PPPP-LPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGA-----GIPLPPPLPG-AG 974
            P  P LPG    P+ P    G P P    G   P  PP P       G P  P   G  G
Sbjct: 389  PGEPGLPGIPG-PMGPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVG 447

Query: 975  IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA-GIPPPPPLPG-AGIPPPPPLPGAGIPP 1032
             P    LPG  I P       G+P  P +PG  G    P +PG  G+  PP +PG G P 
Sbjct: 448  PPGMRGLPGP-IGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPS 506

Query: 1033 ----PPPLPGA----GIPPPPPLPG------AGIPPPPPLPGA-GIPPPPPLPGAGIPPP 1077
                PP +PG     G+P PP  PG      AG+  PP  PGA G    P LPG   P P
Sbjct: 507  GPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGP--PGP 564

Query: 1078 --PPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPL---PGAGIPPP 1132
              PP P A +PP PP  G  +P      G+GI         G+ PP       G    P 
Sbjct: 565  PGPPGPPAVMPPTPPPQGEYLPD----MGLGID--------GVKPPHAYGAKKGKNGGPA 612

Query: 1133 PPLPGAGIPPPPPLPRVGIP 1152
              +P        P P VG P
Sbjct: 613  YEMPAFTAELTAPFPPVGAP 632



 Score = 37.4 bits (85), Expect = 0.13
 Identities = 60/229 (26%), Positives = 83/229 (36%), Gaps = 28/229 (12%)

Query: 196 LSDIQQAIRLQQQQ--QQQLQLQLQQQQQQQQLQGAEEPAAPPTAVSPQPGAFLGLDRFL 253
           + +IQ A R+ ++   ++  ++ L   + +Q  +G   P  PP      PG  +   +  
Sbjct: 90  MKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGPPGPPG-LPGHGIPGIKGK 148

Query: 254 LGPSG--GAGEA-----PGSPDTEQALSALSDLPESLAAEPRE---PQQPPSPGGLPVSE 303
            GP G  G G+      PG P       A  ++ +     P     PQ PP P GLP   
Sbjct: 149 PGPQGYPGVGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIG 208

Query: 304 APSLPA--AQPAAKDSPSSTAFPFPEA--GP-GEEAAGAPVRGAGDTDEEGEEDAF-EDA 357
            P  P    QP  K        P P+   GP G++  G P    G    +G         
Sbjct: 209 KPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMP----GAPGVKGPPGMHGPPG 264

Query: 358 PRGSPGEEWAPEVGEDAPQ----RLGEEPEEEAQGP-DAPAAASLPGSP 401
           P G PG       G   PQ    + G   E   QGP   P     PG P
Sbjct: 265 PVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIP 313



 Score = 35.8 bits (81), Expect = 0.37
 Identities = 59/252 (23%), Positives = 77/252 (30%), Gaps = 21/252 (8%)

Query: 255 GPSG--GAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAPSLPAAQP 312
           GP G  G G  PG P        +   P      P     P   GG+   + P  P  +P
Sbjct: 378 GPIGAPGIGGPPGEPGLPGIPGPMG--PPGAIGFPG----PKGEGGIVGPQGPPGPKGEP 431

Query: 313 AAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAP--RGSPGEEWAPEV 370
             +  P    F      PG      P+   G+  ++G        P   G  GE   P  
Sbjct: 432 GLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKG-VPGLPGVPGLLGPKGEPGIP-- 488

Query: 371 GEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSSPN 430
           G+   Q  G        GP  P     PG P P      P P   P   K     L  P 
Sbjct: 489 GDQGLQ--GPPGIPGIGGPSGPIGP--PGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPP 544

Query: 431 HSP-SQSPNQSPRIKRRPEPSLSRGSRTALASVAAPAKKHRADGGLAAGLSRSADWTEEL 489
             P +  P   P +   P P    G    +     P  ++  D GL              
Sbjct: 545 GKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGID---GVKPPHAY 601

Query: 490 GARTPRVGGSAH 501
           GA+  + GG A+
Sbjct: 602 GAKKGKNGGPAY 613


>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
          Length = 2217

 Score =  162 bits (409), Expect = 3e-39
 Identities = 192/651 (29%), Positives = 261/651 (40%), Gaps = 122/651 (18%)

Query: 692  ELERQYPALDTEVASGHQGLENGVTASGDVCLEALRLEEK----EVRHHRILEAKSIQTS 747
            +LE++ P    EVA   + +E+G     DV + A  + ++    + R  RI  A      
Sbjct: 501  DLEKETP---DEVAQ--EMIESGFFHESDVKIVAKSIRDRVALIQWRRERIWPA----LQ 551

Query: 748  PTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSH--QPTQ 805
            P E+  V       G P +   PP      Q  + ++      P     + D H   PT 
Sbjct: 552  PKEQQDV-------GSPDKARGPP-VPLQVQVTYHAQAGQPGPPEPEEPEADQHLLPPTL 603

Query: 806  SISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTE 865
              S         + +GQG        ++ ++ Q+S +  +  +  ++   PSP    C+ 
Sbjct: 604  PTSATSLASDSTFDSGQGS-------TVYSDSQSSQQSVMLGSLADAA--PSPAQCVCSP 654

Query: 866  SSS-------SMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGA 918
              S       S+P LG    P    PG+ V ++P+ A P  P LQ       P P +  A
Sbjct: 655  PVSEGPVLPQSLPSLGAYQQPTAA-PGLPVGSVPAPACP--PSLQQHF----PDPAMSFA 707

Query: 919  GIPPPPPLPGAGILPLPPLPGAGIPP---PPPLPGAAIPPPPPLPGAGIPLPPPLPGAGI 975
             + PPP  P      +P  PG   PP   PPPL       P PLP    P  P +P   +
Sbjct: 708  PVLPPPSTP------MPTGPGQPAPPGQQPPPL-----AQPTPLPQVLAP-QPVVPLQPV 755

Query: 976  PP--PPPL-PGAGIPPPPPLPGAGIPPPPPLPGAGIPPP-PPLPGAGIPPPPPLPGA-GI 1030
            PP  PP L P + +  P  L    +P  P  P A +PP  PP+P   +PP  PL G  G+
Sbjct: 756  PPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQMPPIP--VVPPITPLAGIDGL 813

Query: 1031 PPP-PPLPGAGIPPPPP---------LPGAGIPPPP-----PLPGAGIPPPP----PLPG 1071
            PP  P LP A +PP PP         LP    P PP     PL    +P PP     +P 
Sbjct: 814  PPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPC 873

Query: 1072 AGIPP--PPPLPGAGIPPP-----------PPLPGAGIPPP--PPLPGVGIPPPPPLPGA 1116
              I P  P  +P   + PP             LPG  + P   P +    +PP P     
Sbjct: 874  RTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQ 933

Query: 1117 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPL--PRVGIPPPPPLPGAGIPPPPPL--PGAG 1172
             +   PP P   +PP P LP   + PP P   P+  +PP P  P   + PP P+  P   
Sbjct: 934  NMRATPPQP--ALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTRPPQPVLPPQPMLPPQPV 991

Query: 1173 IPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTGI 1232
            +PP P LP    P  P LP    P   P     +  P P         P  P+PP     
Sbjct: 992  LPPQPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPVPPAAVLS 1051

Query: 1233 PP-PPLLPVSGPPLLPQVGSS---------TLPTPQVCGFLP---PPLPSG 1270
            PP P +L  + P LLPQ  SS         ++PT Q    LP   PPLP G
Sbjct: 1052 PPLPEVLLPAAPELLPQFPSSLATVSASVQSVPT-QTATLLPPANPPLPGG 1101



 Score = 61.2 bits (147), Expect = 8e-09
 Identities = 75/281 (26%), Positives = 95/281 (33%), Gaps = 40/281 (14%)

Query: 825  PGSQPPHSISTEFQTSHEHSVSSA----FKNS-----------CNIPSPPPLPCTESSSS 869
            PG+ PPH  +    T  E   S A    ++ +           C +   P     ESS  
Sbjct: 1273 PGTSPPHLSTCGLGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAEHPAPEAPESSPP 1332

Query: 870  MPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGA 929
            +P   +    PP     + P     +  + P    ++ L     P    G PP P  P +
Sbjct: 1333 LPLSSL----PPEASQDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSS 1388

Query: 930  GILPLPPLPGAGIPPPPPLPGAAIPPPPPLPG----AGIPLPPPLPGAGIPPPPPLPGAG 985
               P+  LP  G  P      A    P P  G    AG P  P    + +    PL    
Sbjct: 1389 P--PVTALPQDGAAP------ATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETH 1440

Query: 986  IPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1044
              P    P   G+ P  P P A        P   +PPP P P      P P  G   P  
Sbjct: 1441 EAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLL 1500

Query: 1045 PPLPGA-----GIPPPPPLPGAGIPPPPP--LPGAGIPPPP 1078
            P   GA        P PPL G  +PP PP  L   G  PPP
Sbjct: 1501 PAAVGAVSLATSQLPSPPL-GPTVPPQPPSALESDGEGPPP 1540



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 68/248 (27%), Positives = 83/248 (33%), Gaps = 43/248 (17%)

Query: 768  PCPPGAESGPQTKFCS---EISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQ 824
            P P   ES P     S   E S   +P +  +     QP+   SQ      LL  AG   
Sbjct: 1322 PAPEAPESSPPLPLSSLPPEASQDSAPYKDQLS-SKEQPSFLASQ-----QLLSQAGPSN 1375

Query: 825  PGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLP 884
            P   PP  ++                     PS PP+       + P    +P P     
Sbjct: 1376 PPGAPPAPLA---------------------PSSPPVTALPQDGAAPATSTMPEPASGTA 1414

Query: 885  ----GMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGA 940
                G   P   ++ +    PL  T   P    PL   G+ P  P P A        P  
Sbjct: 1415 SQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLV-VGLAPCTPAPEAASTRDASAPRE 1473

Query: 941  GIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGA-----GIPPPPPLPGAGIPPPPP--LP 993
             +PPP P P      P P  G   PL P   GA        P PPL G  +PP PP  L 
Sbjct: 1474 PLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSPPL-GPTVPPQPPSALE 1532

Query: 994  GAGIPPPP 1001
              G  PPP
Sbjct: 1533 SDGEGPPP 1540



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 62/216 (28%), Positives = 72/216 (33%), Gaps = 26/216 (12%)

Query: 909  PPPPPPLPGAGIPPPPPLPGAG-------------ILPLPPLPGAGIPPPPPLPGAAIPP 955
            P   PPLP + +PP      A              +     L  AG   PP  P A + P
Sbjct: 1327 PESSPPLPLSSLPPEASQDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAP 1386

Query: 956  PPPLPGAGIPLPPPLPGAGIPPPPP---LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1012
              P P   +P     P     P P       AG P  P    + +    PL      P  
Sbjct: 1387 SSP-PVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLA 1445

Query: 1013 PLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1071
              P   G+ P  P P A        P   +PPP P P      P P  G   P  P   G
Sbjct: 1446 VQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVG 1505

Query: 1072 A-----GIPPPPPLPGAGIPPPPP--LPGAGIPPPP 1100
            A        P PPL G  +PP PP  L   G  PPP
Sbjct: 1506 AVSLATSQLPSPPL-GPTVPPQPPSALESDGEGPPP 1540



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 79/287 (27%), Positives = 95/287 (33%), Gaps = 38/287 (13%)

Query: 1032 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP----PPPLPGAGIPP 1087
            P P  P +     PPLP + +PP      A  P    L     P        L  AG   
Sbjct: 1322 PAPEAPESS----PPLPLSSLPPEASQDSA--PYKDQLSSKEQPSFLASQQLLSQAGPSN 1375

Query: 1088 PPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPP-----PPPLPG----AGIPPPPPLPGA 1138
            PP     G PP P  P    PP   LP  G  P     P P  G    AG P  P    +
Sbjct: 1376 PP-----GAPPAPLAPSS--PPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQGLTS 1428

Query: 1139 GIPPPPPLPRVGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPP 1197
             +    PL      P    P   G+ P  P P A        P   +PPP P P      
Sbjct: 1429 ELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGT 1488

Query: 1198 PPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPV----SGPPLLPQVG--- 1250
            P P  G   P  P   G         P PP G  +PP P   +     GPP  P+VG   
Sbjct: 1489 PQPALGQPAPLLPAAVGAVSLATSQLPSPPLGPTVPPQPPSALESDGEGPP--PRVGFVD 1546

Query: 1251 --SSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRPMKP 1295
                +L            +P+     G   + G R   +EP R  +P
Sbjct: 1547 STIKSLDEKLRTLLYQEHVPTSSASAGTPVEVGDRDFTLEPLRGDQP 1593



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 70/271 (25%), Positives = 97/271 (35%), Gaps = 65/271 (23%)

Query: 232  PAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEA--PGSP-------DTEQALSALSDLPES 282
            P++PP    PQ GA           SG A +A  PG+P       +T Q L+   + P +
Sbjct: 1386 PSSPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLA 1445

Query: 283  L---------------------AAEPREPQQPPSPGGLPVSEAPSLPAAQPA-------A 314
            +                     A+ PREP  PP+P   P S  P     QPA        
Sbjct: 1446 VQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVG 1505

Query: 315  KDSPSSTAFPFPEAGP----------GEEAAGAPVR-GAGDTDEEGEEDAF------EDA 357
              S +++  P P  GP            +  G P R G  D+  +  ++        E  
Sbjct: 1506 AVSLATSQLPSPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHV 1565

Query: 358  PRGSPGEEWAPEVGED----APQRLGEEPEEEAQGPDAPAAASLPGSP--APSQRCFKPY 411
            P  S       EVG+      P R G++P  E  G D     +LP  P  A S R   P 
Sbjct: 1566 PTSSASAGTPVEVGDRDFTLEPLR-GDQPRSEVCGGD----LALPPVPKEAVSGRVQLPQ 1620

Query: 412  PLITPCYIKTTTRQLSSPNHSPSQSPNQSPR 442
            PL+    +  T   +     S S +   SPR
Sbjct: 1621 PLVEKSELAPTRGAVMEQGTSSSMTAESSPR 1651



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 60/214 (28%), Positives = 77/214 (35%), Gaps = 42/214 (19%)

Query: 758  PPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPP--PPS 815
            PP   LP +P  PP     PQ     +  L   P R         P Q +  P P  PP 
Sbjct: 939  PPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTR---------PPQPVLPPQPMLPP- 988

Query: 816  LLWSAGQGQPGSQPPHSISTEFQTSH--EHSVSSAFKNSCNIPSPPPLPCTESSSSMPGL 873
                  Q     QP   +  E    H  E +  +A   S  +   P     + ++ +P  
Sbjct: 989  ------QPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVP-- 1040

Query: 874  GMVPPPP-----PPLPGMTVPTLPS------------TAIPQPPPLQGTEMLPPPPPPLP 916
              VP PP     PPLP + +P  P             +A  Q  P Q   +LPP  PPLP
Sbjct: 1041 -TVPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSVPTQTATLLPPANPPLP 1099

Query: 917  GA-GIPPPPPLPGAGILPLPPLPGAGIPPPPPLP 949
            G  GI  P P     + P+     A    PP LP
Sbjct: 1100 GGPGIASPCPTVQLTVEPVQE-EQASQDKPPGLP 1132



 Score = 40.4 bits (93), Expect = 0.015
 Identities = 60/242 (24%), Positives = 86/242 (35%), Gaps = 17/242 (7%)

Query: 208  QQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSP 267
            ++ +Q Q      QQ     G       P A  P P A        L           +P
Sbjct: 1289 EESRQSQANAPVYQQNVLHTGKRWFIICPVAEHPAPEAPESSPPLPLSSLPPEASQDSAP 1348

Query: 268  DTEQALSALSDLPESLAAEPREPQQPPS--PGGLPVSEAPSLPAAQPAAKD--SPSSTAF 323
              +Q  S   + P  LA++    Q  PS  PG  P   APS P      +D  +P+++  
Sbjct: 1349 YKDQLSS--KEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSSPPVTALPQDGAAPATSTM 1406

Query: 324  PFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFE--DAPRGSP----GEEWAPEVGEDAPQR 377
            P P +G   +A G        ++ E  +   E  +AP        G        E A  R
Sbjct: 1407 PEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAASTR 1466

Query: 378  LGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCY--IKTTTRQLSSPNHSPSQ 435
                P E    P AP  +   G+P P+    +P PL+      +   T QL SP   P+ 
Sbjct: 1467 DASAPREPLP-PPAPEPSPHSGTPQPA--LGQPAPLLPAAVGAVSLATSQLPSPPLGPTV 1523

Query: 436  SP 437
             P
Sbjct: 1524 PP 1525



 Score = 36.6 bits (83), Expect = 0.22
 Identities = 60/242 (24%), Positives = 79/242 (32%), Gaps = 34/242 (14%)

Query: 224 QQLQGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESL 283
           QQ     +P   P  ++PQP   L      L P        G+P   + L       + L
Sbjct: 729 QQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPL 788

Query: 284 AAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPE-------------AGP 330
           A  P  PQ PP P   P++    +    PA  D P++T  P P              A P
Sbjct: 789 AQVP--PQMPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAP 846

Query: 331 GEEAAGA-PVRGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGP 389
              A+ A P++        G       AP   P     P      P  L   P   A   
Sbjct: 847 LPPASPALPLQAVKLPHPPG-------APLAMPCRTIVPNAPATIP-LLAVAPPGVAALS 898

Query: 390 DAPAAASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSSPNHSPSQSPNQSPRIKRRPEP 449
              A A LPG P         YP   P    T      SP+H+        P+    P+P
Sbjct: 899 IHSAVAQLPGQPV--------YPAAFPQMAPTDVP--PSPHHTVQNMRATPPQPALPPQP 948

Query: 450 SL 451
           +L
Sbjct: 949 TL 950



 Score = 36.2 bits (82), Expect = 0.28
 Identities = 51/177 (28%), Positives = 65/177 (36%), Gaps = 22/177 (12%)

Query: 234 APPTAVSPQPGAFLGLDRFLLG------PSGGAGEAPGS--PDTEQALSALSDLPESLAA 285
           A P A + +PG    L R ++       P   A EAPG   P   Q    L      L A
Sbjct: 27  AEPRAKAARPGPQRFLRRSVVESDQEEPPGLEAAEAPGPQPPQPLQRRVLLLCKTRRLIA 86

Query: 286 EPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTA-FPFPEAGPGEEAAGAPVRGAGD 344
           E           G P + AP+   AQP A  +P+     P     PG +   A V  A  
Sbjct: 87  ERAR--------GRPAAPAPAALVAQPGAPGAPADAGPEPVGTQEPGPDPIAAAVETAPA 138

Query: 345 TDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGPD--APAAASLPG 399
            D    E+A   A      +E A E   +  +   +EPEEE    D     A SL G
Sbjct: 139 PDGGPREEA---AATVRKEDEGAAEAKPEPGRTRRDEPEEEEDDEDDLKAVATSLDG 192



 Score = 33.5 bits (75), Expect = 1.8
 Identities = 54/211 (25%), Positives = 67/211 (31%), Gaps = 34/211 (16%)

Query: 144 PGGPGPAEARVGGRPIAEDVETAAGAQDGQRTSSGSDTDIYSFHSATEQEDLLSDIQQAI 203
           PG P P E       +   + T+A       TS  SD+   S   +T   D         
Sbjct: 584 PGPPEPEEPEADQHLLPPTLPTSA-------TSLASDSTFDSGQGSTVYSD--------- 627

Query: 204 RLQQQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSG---GA 260
              Q  QQ + L           Q    P      V PQ    LG  +      G   G+
Sbjct: 628 --SQSSQQSVMLGSLADAAPSPAQCVCSPPVSEGPVLPQSLPSLGAYQQPTAAPGLPVGS 685

Query: 261 GEAPGSPDTEQ------ALSALSDLPESLAAEPREPQQPPSPGGLPVSEA-----PSLPA 309
             AP  P + Q      A+S    LP      P  P QP  PG  P   A     P + A
Sbjct: 686 VPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTGPGQPAPPGQQPPPLAQPTPLPQVLA 745

Query: 310 AQPAAKDSPSSTAFPFPEAGPGEEAAGAPVR 340
            QP     P     P P   P  +  GAP +
Sbjct: 746 PQPVVPLQPVPPHLP-PYLAPASQ-VGAPAQ 774



 Score = 32.7 bits (73), Expect = 3.1
 Identities = 63/276 (22%), Positives = 94/276 (34%), Gaps = 40/276 (14%)

Query: 232  PAAPPT----AVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALS--DLPES--- 282
            P AP T    AV+P   A L +            + PG P    A   ++  D+P S   
Sbjct: 878  PNAPATIPLLAVAPPGVAALSIH-------SAVAQLPGQPVYPAAFPQMAPTDVPPSPHH 930

Query: 283  ----LAAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAP 338
                + A P +P  PP P   P    P  P   P     P  T  P P   P       P
Sbjct: 931  TVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTRPPQPVLPPQPMLPPQP 990

Query: 339  V---RGAGDTDEEGEEDAFED--APRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGPDAPA 393
            V   + A     E  +    +  AP  +PG +    +G  AP  +    +  AQ P  P 
Sbjct: 991  VLPPQPALPVRPEPLQPHLPEQAAPAATPGSQIL--LGHPAPYAV----DVAAQVPTVPV 1044

Query: 394  AASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSSPNHSPSQSPNQSPRIKRRPEPSLSR 453
              +   SP   +      P + P +       L++ + S    P Q+  +     P L  
Sbjct: 1045 PPAAVLSPPLPEVLLPAAPELLPQF----PSSLATVSASVQSVPTQTATLLPPANPPLPG 1100

Query: 454  GSRTA-----LASVAAPAKKHRADGGLAAGLSRSAD 484
            G   A     +     P ++ +A      GL +S +
Sbjct: 1101 GPGIASPCPTVQLTVEPVQEEQASQDKPPGLPQSCE 1136


>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
            sapiens]
          Length = 503

 Score =  156 bits (394), Expect = 2e-37
 Identities = 130/370 (35%), Positives = 147/370 (39%), Gaps = 72/370 (19%)

Query: 880  PPPLPGMT---VPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPP 936
            PP L G+    +P L STA        G    P  PP        P  P  G G  P+P 
Sbjct: 97   PPGLGGLFQAGMPKLRSTANRDND--SGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPS 154

Query: 937  LPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIP--------PPPPLPGAGIPP 988
             PG    PP P      PP P +      +PPP+P    P          PP+PG    P
Sbjct: 155  -PGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGG---P 210

Query: 989  PPPLPGAGIPPPPPLPG-------AGIPPPPPL----PGAGIPPPPPLPGAGIPPPPPLP 1037
              P PG   P PPP PG        G     PL    P +  PP PP P   +   PP  
Sbjct: 211  RQPSPG---PTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP-- 265

Query: 1038 GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1097
                PPPPP+        P +    +PPPPP       P  P P A    PPP      P
Sbjct: 266  ----PPPPPVGNR-----PSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPP------P 310

Query: 1098 PPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIP-----PPPPLPGAGIPPPPPLPRVGIP 1152
            PPP  PG   PPP P   +G    P LP   +      PP P PG   P PPP P    P
Sbjct: 311  PPPSRPG---PPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPP-PSERPP 366

Query: 1153 PP---PPLPGAGIPPPPPLPGAG-----IPPPPPLP---GVGIPPPPPLPGVGIPPPPPL 1201
            PP   PP     +PPPPP+   G     +P  P LP   GV  P   P P    P PP  
Sbjct: 367  PPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRP----PLPPDR 422

Query: 1202 PGAGIPPPPP 1211
            P AG PPPPP
Sbjct: 423  PSAGAPPPPP 432



 Score =  152 bits (383), Expect = 4e-36
 Identities = 141/451 (31%), Positives = 172/451 (38%), Gaps = 94/451 (20%)

Query: 821  GQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPL--PCTESSSSMPGLGMVPP 878
            G G  G   P  +   FQ       S+A +++ +  S PPL  P   S+S+ P       
Sbjct: 88   GGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPF------ 141

Query: 879  PPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPL---- 934
             PP  PG     +PS      PP      +PPP P +       PPP+P     P+    
Sbjct: 142  SPPSGPGRF--PVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTP-RPIQSSP 198

Query: 935  -----PPLPGAGIPPPPPLPGAAIPPPPPLPG-----------AGIPLPPPLPGAGIPPP 978
                 PP+PG    P  P PG   P PPP PG              PL    P +  PP 
Sbjct: 199  HNRGSPPVPGG---PRQPSPG---PTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPL 252

Query: 979  PPLPGAGI---PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1035
            PP P   +   PPPPP P   +   P +    +PPPPP       P  P P A    PPP
Sbjct: 253  PPTPSRALDDKPPPPPPP---VGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPP 309

Query: 1036 LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI---PPPPPLPGAGIPPPPPLP 1092
                  PPPP  PG   PPP P   +G    P LP   +      PPLP  G   P P P
Sbjct: 310  ------PPPPSRPG---PPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPP 360

Query: 1093 GAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAG-----IPPPPPLPG-AGIPPPPPL 1146
             +  PPPP      +  PP   G  +PPPPP+   G     +P  P LP  +G+  P   
Sbjct: 361  PSERPPPP------VRDPPGRSGP-LPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSG 413

Query: 1147 PRVGIPPPPPLPGAGIPPPPP------------------------LPGAGIPPPPPLPGV 1182
            PR   P PP  P AG PPPPP                         P + +PPP P    
Sbjct: 414  PRP--PLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQT 471

Query: 1183 GIPPPPPLPGVGIPPPPPLPGAGIPPPPPLP 1213
                P  L              G PP PP+P
Sbjct: 472  TKSYPSKLARNESRSGSNRRERGAPPLPPIP 502



 Score =  148 bits (374), Expect = 4e-35
 Identities = 126/348 (36%), Positives = 140/348 (40%), Gaps = 76/348 (21%)

Query: 923  PPPLPGAG----ILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPP 978
            PP LP  G      P  P  G G  P P  PG    PP P       +PPP P  G  P 
Sbjct: 126  PPLLPPGGRSTSAKPFSPPSGPGRFPVPS-PGHRSGPPEPQRNR---MPPPRPDVGSKPD 181

Query: 979  PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1038
                   IPPP P     I   P   G+     PP+PG    P  P PG   P PPP PG
Sbjct: 182  ------SIPPPVPSTPRPIQSSPHNRGS-----PPVPGG---PRQPSPG---PTPPPFPG 224

Query: 1039 -------AGIPPPPPL----PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1087
                    G     PL    P +  PP PP P   +   PP      PPPPP+       
Sbjct: 225  NRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP------PPPPPVGNR---- 274

Query: 1088 PPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1147
             P +    +PPPPP       P  P P A    PPP      PPPP  PG   PPP P  
Sbjct: 275  -PSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPP------PPPPSRPG---PPPLPPS 324

Query: 1148 RVGIPPPPPLPGAGIP-----PPPPLPGAGIPPPPPLPGVGIPPP---PPLPGVGIPPPP 1199
              G    P LP   +      PP P PG   P PPP P    PPP   PP     +PPPP
Sbjct: 325  SSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPP-PSERPPPPVRDPPGRSGPLPPPP 383

Query: 1200 PLPGAG-----IPPPPPLP---GMGIPPA-PAPPLPP--PGTGIPPPP 1236
            P+   G     +P  P LP   G+  P + P PPLPP  P  G PPPP
Sbjct: 384  PVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPP 431



 Score =  144 bits (363), Expect = 7e-34
 Identities = 131/411 (31%), Positives = 154/411 (37%), Gaps = 110/411 (26%)

Query: 820  AGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPP 879
            +G  +P   PP   ST  +     S    F        P P P   S    P    +PPP
Sbjct: 121  SGGSRPPLLPPGGRSTSAKPFSPPSGPGRF--------PVPSPGHRSGPPEPQRNRMPPP 172

Query: 880  PPPL---PGMTVPTLPSTAIP--QPPPLQGTEMLPPPP-PPLPGAGIPPPPPLPG----- 928
             P +   P    P +PST  P    P  +G+  +P  P  P PG   P PPP PG     
Sbjct: 173  RPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPG---PTPPPFPGNRGTA 229

Query: 929  --AGILPLPPL----PGAGIPPPPPLPGAAI---PPPPPLPGAGIPLPPPLPGAGIPPPP 979
               G +   PL    P +  PP PP P  A+   PPPPP P   +   P +    +PPPP
Sbjct: 230  LGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPP---VGNRPSIHREAVPPPP 286

Query: 980  PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA 1039
            P       P  P P A    PPP      PPPP  PG   PPP P   +G    P LP  
Sbjct: 287  PQNNKPPVPSTPRPSASSQAPPP------PPPPSRPG---PPPLPPSSSGNDETPRLPQR 337

Query: 1040 GIP-----PPPPLPGAGIPPPPPLPGAGIPPP---PPLPGAGIPPPPPLPGAG-----IP 1086
             +      PP P PG   P PPP P    PPP   PP     +PPPPP+   G     +P
Sbjct: 338  NLSLSSSTPPLPSPGRSGPLPPP-PSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALP 396

Query: 1087 PPPPLP---GAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPL------------------- 1124
              P LP   G   P   P P    P PP  P AG PPPPP                    
Sbjct: 397  ATPQLPSRSGVDSPRSGPRP----PLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWES 452

Query: 1125 -----PGAGIPPPPPLPGA----------------------GIPPPPPLPR 1148
                 P + +PPP P                          G PP PP+PR
Sbjct: 453  RFYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPIPR 503



 Score =  120 bits (300), Expect = 1e-26
 Identities = 106/336 (31%), Positives = 130/336 (38%), Gaps = 71/336 (21%)

Query: 994  GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG-IPPPPPLPGA-- 1050
            G   PP  P  G      P  P +G P   P+P  G    PP P    +PPP P  G+  
Sbjct: 122  GGSRPPLLPPGGRSTSAKPFSPPSG-PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKP 180

Query: 1051 -GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPP 1109
              IPPP P     I   P   G+     PP+PG    P  P PG   P PPP PG     
Sbjct: 181  DSIPPPVPSTPRPIQSSPHNRGS-----PPVPGG---PRQPSPG---PTPPPFPG---NR 226

Query: 1110 PPPLPGAGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPP 1166
               L G  I   P     P +  PP PP P   +   PP      PPPPP+        P
Sbjct: 227  GTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP------PPPPPVGNR-----P 275

Query: 1167 PLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLP------------- 1213
             +    +PPPPP       P  P P      PPP P    P PPPLP             
Sbjct: 276  SIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335

Query: 1214 ------GMGIPPAPAP----PLPPPGTGIPPPPLL-------PVSGPPLLPQVGSSTLPT 1256
                      PP P+P    PLPPP +  PPPP+        P+  PP + + GS++   
Sbjct: 336  QRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRAL 395

Query: 1257 PQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRP 1292
            P       P LPS     G++  +   + P+ P RP
Sbjct: 396  PAT-----PQLPS---RSGVDSPRSGPRPPLPPDRP 423



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 78/276 (28%), Positives = 97/276 (35%), Gaps = 43/276 (15%)

Query: 743 SIQTSPTEEGGVLT----LPP-----VDGLPGRPPCPPG------AESGPQTKFCSEISL 787
           SI+ SP       +    LPP     +D  P  PP P G       E+ P     +    
Sbjct: 234 SIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPP 293

Query: 788 IVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSS 847
           + S  R S    +  P    S+P PPP    S+G  +    P  ++S    T    S   
Sbjct: 294 VPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPG- 352

Query: 848 AFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLP--GMTVPTLPSTAIPQPPPLQGT 905
               S  +P PP           PG     PPPPP+   G T   LP+T  PQ P   G 
Sbjct: 353 ---RSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPAT--PQLPSRSGV 407

Query: 906 EM-----LPPPPPPLPGAGIPPPPPLPGAGI---LPLPPL-----------PGAGIPPPP 946
           +       PP PP  P AG PPPPP P   I       P            P + +PPP 
Sbjct: 408 DSPRSGPRPPLPPDRPSAGAPPPPP-PSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPE 466

Query: 947 PLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLP 982
           P        P  L              G PP PP+P
Sbjct: 467 PYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPIP 502



 Score = 36.6 bits (83), Expect = 0.22
 Identities = 98/429 (22%), Positives = 131/429 (30%), Gaps = 99/429 (23%)

Query: 38  GSGGKKALGKHGKGGGGGGGGGESGKKKSKSDSRASVFSNL-RIRKNLSKGKGAGGSRED 96
           G GG    G  G GGGGGGGGG S              + + ++R   ++   +GGSR  
Sbjct: 68  GGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPP 127

Query: 97  VLDSQALQTGELDSAHSLLTKTPDLSLSADEAGLSDTECADPFEVTGPGGPG----PAEA 152
           +L      T                              A PF  + P GPG    P+  
Sbjct: 128 LLPPGGRSTS-----------------------------AKPF--SPPSGPGRFPVPSPG 156

Query: 153 RVGGRPIAEDVETAAGAQDGQRTSSGSDTDIYSFHSATEQEDLLSDIQQAIRLQQQQQQQ 212
              G P     E         R   GS  D                I   +       + 
Sbjct: 157 HRSGPP-----EPQRNRMPPPRPDVGSKPD---------------SIPPPV---PSTPRP 193

Query: 213 LQLQLQQQQQQQQLQGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSP-DTEQ 271
           +Q     +       G  +P+  PT   P PG          G + G G    SP  +  
Sbjct: 194 IQSSPHNRGSPPVPGGPRQPSPGPTP-PPFPGN--------RGTALGGGSIRQSPLSSSS 244

Query: 272 ALSALSDLP--ESLAAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAG 329
             S    LP   S A + + P  PP  G  P     ++P   P   + P   + P P A 
Sbjct: 245 PFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVP-PPPPQNNKPPVPSTPRPSAS 303

Query: 330 PGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGP 389
                   P    G              P  S G +  P +    PQR           P
Sbjct: 304 SQAPPPPPPPSRPGP----------PPLPPSSSGNDETPRL----PQRNLSLSSSTPPLP 349

Query: 390 DAPAAASLPGSPAPSQRCFKPY--------PLITPCYIK---TTTRQLSSPNHSPSQSPN 438
               +  LP  P PS+R   P         PL  P  +    +T+R L +    PS+S  
Sbjct: 350 SPGRSGPLP--PPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGV 407

Query: 439 QSPRIKRRP 447
            SPR   RP
Sbjct: 408 DSPRSGPRP 416



 Score = 31.6 bits (70), Expect = 7.0
 Identities = 60/251 (23%), Positives = 80/251 (31%), Gaps = 49/251 (19%)

Query: 228 GAEEPAAPPTAVSPQPGAFL---GLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLA 284
           G+  P  PP   S     F    G  RF + PS G    P  P                 
Sbjct: 123 GSRPPLLPPGGRSTSAKPFSPPSGPGRFPV-PSPGHRSGPPEPQRN-------------- 167

Query: 285 AEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAG-------- 336
              R P   P  G  P S  P +P+     + SP +   P    GP + + G        
Sbjct: 168 ---RMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPG 224

Query: 337 --APVRGAGDTDEE--GEEDAFEDAPRGSPGEEWA-PEVGEDAPQRLGEEP--EEEAQGP 389
                 G G   +        F + P   P    A  +     P  +G  P    EA  P
Sbjct: 225 NRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPP 284

Query: 390 DAPA--AASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSSPNHSPSQSPN-QSPRIKRR 446
             P      +P +P PS     P P   P        +   P   PS S N ++PR+   
Sbjct: 285 PPPQNNKPPVPSTPRPSASSQAPPPPPPP-------SRPGPPPLPPSSSGNDETPRL--- 334

Query: 447 PEPSLSRGSRT 457
           P+ +LS  S T
Sbjct: 335 PQRNLSLSSST 345


>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
            sapiens]
          Length = 503

 Score =  156 bits (394), Expect = 2e-37
 Identities = 130/370 (35%), Positives = 147/370 (39%), Gaps = 72/370 (19%)

Query: 880  PPPLPGMT---VPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPP 936
            PP L G+    +P L STA        G    P  PP        P  P  G G  P+P 
Sbjct: 97   PPGLGGLFQAGMPKLRSTANRDND--SGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPS 154

Query: 937  LPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIP--------PPPPLPGAGIPP 988
             PG    PP P      PP P +      +PPP+P    P          PP+PG    P
Sbjct: 155  -PGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGG---P 210

Query: 989  PPPLPGAGIPPPPPLPG-------AGIPPPPPL----PGAGIPPPPPLPGAGIPPPPPLP 1037
              P PG   P PPP PG        G     PL    P +  PP PP P   +   PP  
Sbjct: 211  RQPSPG---PTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP-- 265

Query: 1038 GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1097
                PPPPP+        P +    +PPPPP       P  P P A    PPP      P
Sbjct: 266  ----PPPPPVGNR-----PSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPP------P 310

Query: 1098 PPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIP-----PPPPLPGAGIPPPPPLPRVGIP 1152
            PPP  PG   PPP P   +G    P LP   +      PP P PG   P PPP P    P
Sbjct: 311  PPPSRPG---PPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPP-PSERPP 366

Query: 1153 PP---PPLPGAGIPPPPPLPGAG-----IPPPPPLP---GVGIPPPPPLPGVGIPPPPPL 1201
            PP   PP     +PPPPP+   G     +P  P LP   GV  P   P P    P PP  
Sbjct: 367  PPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRP----PLPPDR 422

Query: 1202 PGAGIPPPPP 1211
            P AG PPPPP
Sbjct: 423  PSAGAPPPPP 432



 Score =  152 bits (383), Expect = 4e-36
 Identities = 141/451 (31%), Positives = 172/451 (38%), Gaps = 94/451 (20%)

Query: 821  GQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPL--PCTESSSSMPGLGMVPP 878
            G G  G   P  +   FQ       S+A +++ +  S PPL  P   S+S+ P       
Sbjct: 88   GGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPF------ 141

Query: 879  PPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPL---- 934
             PP  PG     +PS      PP      +PPP P +       PPP+P     P+    
Sbjct: 142  SPPSGPGRF--PVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTP-RPIQSSP 198

Query: 935  -----PPLPGAGIPPPPPLPGAAIPPPPPLPG-----------AGIPLPPPLPGAGIPPP 978
                 PP+PG    P  P PG   P PPP PG              PL    P +  PP 
Sbjct: 199  HNRGSPPVPGG---PRQPSPG---PTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPL 252

Query: 979  PPLPGAGI---PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1035
            PP P   +   PPPPP P   +   P +    +PPPPP       P  P P A    PPP
Sbjct: 253  PPTPSRALDDKPPPPPPP---VGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPP 309

Query: 1036 LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI---PPPPPLPGAGIPPPPPLP 1092
                  PPPP  PG   PPP P   +G    P LP   +      PPLP  G   P P P
Sbjct: 310  ------PPPPSRPG---PPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPP 360

Query: 1093 GAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAG-----IPPPPPLPG-AGIPPPPPL 1146
             +  PPPP      +  PP   G  +PPPPP+   G     +P  P LP  +G+  P   
Sbjct: 361  PSERPPPP------VRDPPGRSGP-LPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSG 413

Query: 1147 PRVGIPPPPPLPGAGIPPPPP------------------------LPGAGIPPPPPLPGV 1182
            PR   P PP  P AG PPPPP                         P + +PPP P    
Sbjct: 414  PRP--PLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQT 471

Query: 1183 GIPPPPPLPGVGIPPPPPLPGAGIPPPPPLP 1213
                P  L              G PP PP+P
Sbjct: 472  TKSYPSKLARNESRSGSNRRERGAPPLPPIP 502



 Score =  148 bits (374), Expect = 4e-35
 Identities = 126/348 (36%), Positives = 140/348 (40%), Gaps = 76/348 (21%)

Query: 923  PPPLPGAG----ILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPP 978
            PP LP  G      P  P  G G  P P  PG    PP P       +PPP P  G  P 
Sbjct: 126  PPLLPPGGRSTSAKPFSPPSGPGRFPVPS-PGHRSGPPEPQRNR---MPPPRPDVGSKPD 181

Query: 979  PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1038
                   IPPP P     I   P   G+     PP+PG    P  P PG   P PPP PG
Sbjct: 182  ------SIPPPVPSTPRPIQSSPHNRGS-----PPVPGG---PRQPSPG---PTPPPFPG 224

Query: 1039 -------AGIPPPPPL----PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1087
                    G     PL    P +  PP PP P   +   PP      PPPPP+       
Sbjct: 225  NRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP------PPPPPVGNR---- 274

Query: 1088 PPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1147
             P +    +PPPPP       P  P P A    PPP      PPPP  PG   PPP P  
Sbjct: 275  -PSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPP------PPPPSRPG---PPPLPPS 324

Query: 1148 RVGIPPPPPLPGAGIP-----PPPPLPGAGIPPPPPLPGVGIPPP---PPLPGVGIPPPP 1199
              G    P LP   +      PP P PG   P PPP P    PPP   PP     +PPPP
Sbjct: 325  SSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPP-PSERPPPPVRDPPGRSGPLPPPP 383

Query: 1200 PLPGAG-----IPPPPPLP---GMGIPPA-PAPPLPP--PGTGIPPPP 1236
            P+   G     +P  P LP   G+  P + P PPLPP  P  G PPPP
Sbjct: 384  PVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPP 431



 Score =  144 bits (363), Expect = 7e-34
 Identities = 131/411 (31%), Positives = 154/411 (37%), Gaps = 110/411 (26%)

Query: 820  AGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPP 879
            +G  +P   PP   ST  +     S    F        P P P   S    P    +PPP
Sbjct: 121  SGGSRPPLLPPGGRSTSAKPFSPPSGPGRF--------PVPSPGHRSGPPEPQRNRMPPP 172

Query: 880  PPPL---PGMTVPTLPSTAIP--QPPPLQGTEMLPPPP-PPLPGAGIPPPPPLPG----- 928
             P +   P    P +PST  P    P  +G+  +P  P  P PG   P PPP PG     
Sbjct: 173  RPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPG---PTPPPFPGNRGTA 229

Query: 929  --AGILPLPPL----PGAGIPPPPPLPGAAI---PPPPPLPGAGIPLPPPLPGAGIPPPP 979
               G +   PL    P +  PP PP P  A+   PPPPP P   +   P +    +PPPP
Sbjct: 230  LGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPP---VGNRPSIHREAVPPPP 286

Query: 980  PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA 1039
            P       P  P P A    PPP      PPPP  PG   PPP P   +G    P LP  
Sbjct: 287  PQNNKPPVPSTPRPSASSQAPPP------PPPPSRPG---PPPLPPSSSGNDETPRLPQR 337

Query: 1040 GIP-----PPPPLPGAGIPPPPPLPGAGIPPP---PPLPGAGIPPPPPLPGAG-----IP 1086
             +      PP P PG   P PPP P    PPP   PP     +PPPPP+   G     +P
Sbjct: 338  NLSLSSSTPPLPSPGRSGPLPPP-PSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALP 396

Query: 1087 PPPPLP---GAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPL------------------- 1124
              P LP   G   P   P P    P PP  P AG PPPPP                    
Sbjct: 397  ATPQLPSRSGVDSPRSGPRP----PLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWES 452

Query: 1125 -----PGAGIPPPPPLPGA----------------------GIPPPPPLPR 1148
                 P + +PPP P                          G PP PP+PR
Sbjct: 453  RFYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPIPR 503



 Score =  120 bits (300), Expect = 1e-26
 Identities = 106/336 (31%), Positives = 130/336 (38%), Gaps = 71/336 (21%)

Query: 994  GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG-IPPPPPLPGA-- 1050
            G   PP  P  G      P  P +G P   P+P  G    PP P    +PPP P  G+  
Sbjct: 122  GGSRPPLLPPGGRSTSAKPFSPPSG-PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKP 180

Query: 1051 -GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPP 1109
              IPPP P     I   P   G+     PP+PG    P  P PG   P PPP PG     
Sbjct: 181  DSIPPPVPSTPRPIQSSPHNRGS-----PPVPGG---PRQPSPG---PTPPPFPG---NR 226

Query: 1110 PPPLPGAGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPP 1166
               L G  I   P     P +  PP PP P   +   PP      PPPPP+        P
Sbjct: 227  GTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP------PPPPPVGNR-----P 275

Query: 1167 PLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLP------------- 1213
             +    +PPPPP       P  P P      PPP P    P PPPLP             
Sbjct: 276  SIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335

Query: 1214 ------GMGIPPAPAP----PLPPPGTGIPPPPLL-------PVSGPPLLPQVGSSTLPT 1256
                      PP P+P    PLPPP +  PPPP+        P+  PP + + GS++   
Sbjct: 336  QRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRAL 395

Query: 1257 PQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRP 1292
            P       P LPS     G++  +   + P+ P RP
Sbjct: 396  PAT-----PQLPS---RSGVDSPRSGPRPPLPPDRP 423



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 78/276 (28%), Positives = 97/276 (35%), Gaps = 43/276 (15%)

Query: 743 SIQTSPTEEGGVLT----LPP-----VDGLPGRPPCPPG------AESGPQTKFCSEISL 787
           SI+ SP       +    LPP     +D  P  PP P G       E+ P     +    
Sbjct: 234 SIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPP 293

Query: 788 IVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSS 847
           + S  R S    +  P    S+P PPP    S+G  +    P  ++S    T    S   
Sbjct: 294 VPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPG- 352

Query: 848 AFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLP--GMTVPTLPSTAIPQPPPLQGT 905
               S  +P PP           PG     PPPPP+   G T   LP+T  PQ P   G 
Sbjct: 353 ---RSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPAT--PQLPSRSGV 407

Query: 906 EM-----LPPPPPPLPGAGIPPPPPLPGAGI---LPLPPL-----------PGAGIPPPP 946
           +       PP PP  P AG PPPPP P   I       P            P + +PPP 
Sbjct: 408 DSPRSGPRPPLPPDRPSAGAPPPPP-PSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPE 466

Query: 947 PLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLP 982
           P        P  L              G PP PP+P
Sbjct: 467 PYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPIP 502



 Score = 36.6 bits (83), Expect = 0.22
 Identities = 98/429 (22%), Positives = 131/429 (30%), Gaps = 99/429 (23%)

Query: 38  GSGGKKALGKHGKGGGGGGGGGESGKKKSKSDSRASVFSNL-RIRKNLSKGKGAGGSRED 96
           G GG    G  G GGGGGGGGG S              + + ++R   ++   +GGSR  
Sbjct: 68  GGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPP 127

Query: 97  VLDSQALQTGELDSAHSLLTKTPDLSLSADEAGLSDTECADPFEVTGPGGPG----PAEA 152
           +L      T                              A PF  + P GPG    P+  
Sbjct: 128 LLPPGGRSTS-----------------------------AKPF--SPPSGPGRFPVPSPG 156

Query: 153 RVGGRPIAEDVETAAGAQDGQRTSSGSDTDIYSFHSATEQEDLLSDIQQAIRLQQQQQQQ 212
              G P     E         R   GS  D                I   +       + 
Sbjct: 157 HRSGPP-----EPQRNRMPPPRPDVGSKPD---------------SIPPPV---PSTPRP 193

Query: 213 LQLQLQQQQQQQQLQGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSP-DTEQ 271
           +Q     +       G  +P+  PT   P PG          G + G G    SP  +  
Sbjct: 194 IQSSPHNRGSPPVPGGPRQPSPGPTP-PPFPGN--------RGTALGGGSIRQSPLSSSS 244

Query: 272 ALSALSDLP--ESLAAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAG 329
             S    LP   S A + + P  PP  G  P     ++P   P   + P   + P P A 
Sbjct: 245 PFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVP-PPPPQNNKPPVPSTPRPSAS 303

Query: 330 PGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGP 389
                   P    G              P  S G +  P +    PQR           P
Sbjct: 304 SQAPPPPPPPSRPGP----------PPLPPSSSGNDETPRL----PQRNLSLSSSTPPLP 349

Query: 390 DAPAAASLPGSPAPSQRCFKPY--------PLITPCYIK---TTTRQLSSPNHSPSQSPN 438
               +  LP  P PS+R   P         PL  P  +    +T+R L +    PS+S  
Sbjct: 350 SPGRSGPLP--PPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGV 407

Query: 439 QSPRIKRRP 447
            SPR   RP
Sbjct: 408 DSPRSGPRP 416



 Score = 31.6 bits (70), Expect = 7.0
 Identities = 60/251 (23%), Positives = 80/251 (31%), Gaps = 49/251 (19%)

Query: 228 GAEEPAAPPTAVSPQPGAFL---GLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLA 284
           G+  P  PP   S     F    G  RF + PS G    P  P                 
Sbjct: 123 GSRPPLLPPGGRSTSAKPFSPPSGPGRFPV-PSPGHRSGPPEPQRN-------------- 167

Query: 285 AEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAG-------- 336
              R P   P  G  P S  P +P+     + SP +   P    GP + + G        
Sbjct: 168 ---RMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPG 224

Query: 337 --APVRGAGDTDEE--GEEDAFEDAPRGSPGEEWA-PEVGEDAPQRLGEEP--EEEAQGP 389
                 G G   +        F + P   P    A  +     P  +G  P    EA  P
Sbjct: 225 NRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPP 284

Query: 390 DAPA--AASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSSPNHSPSQSPN-QSPRIKRR 446
             P      +P +P PS     P P   P        +   P   PS S N ++PR+   
Sbjct: 285 PPPQNNKPPVPSTPRPSASSQAPPPPPPP-------SRPGPPPLPPSSSGNDETPRL--- 334

Query: 447 PEPSLSRGSRT 457
           P+ +LS  S T
Sbjct: 335 PQRNLSLSSST 345


>gi|52485606 formin-like 2 [Homo sapiens]
          Length = 1092

 Score =  155 bits (392), Expect = 3e-37
 Identities = 152/589 (25%), Positives = 253/589 (42%), Gaps = 95/589 (16%)

Query: 1136 PGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGI 1195
            P  G     PLP    PPPPPLP +   P     G   PP PP P    PPPPP P    
Sbjct: 516  PTMGAASSGPLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP---- 563

Query: 1196 PPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLP 1255
            PPPPP      PPPPPLPG      PAPPL PP    PP P             G+S+  
Sbjct: 564  PPPPP------PPPPPLPGPAAETVPAPPLAPPLPSAPPLP-------------GTSS-- 602

Query: 1256 TPQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRIQLHSKRDSSTSLIW 1315
                        P+ +F  G+   K   K+PI+    M    W  +    K +     ++
Sbjct: 603  ------------PTVVFNSGLAAVK--IKKPIKTKFRMPVFNWVAL----KPNQINGTVF 644

Query: 1316 EKIEEPSI----DCHEFEELFSKTAVKERKKPISDTISK--TKAKQVVKLLSNKRSQAVG 1369
             +I++  I    +  EFEE+F KT  +     +S +  K   K    V LL   R++ + 
Sbjct: 645  NEIDDERILEDLNVDEFEEIF-KTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLA 703

Query: 1370 ILMSSLHLDMKDIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIEKHGRSSKDKENAK 1429
            I +        +I  A+   D   + ++ ++ L       +E++ +  + R  K  EN  
Sbjct: 704  ITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLEN-- 761

Query: 1430 SLDKPEQFLYELSLIPNFSERVFCILFQSTFSESICSIRRKLELLQKLCETLKNGPGVMQ 1489
             L   ++F+ + S I    +++  + F   F+ESI  +  +L  +     ++K+   + +
Sbjct: 762  -LSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKK 820

Query: 1490 VLGLVLAFGNYMNGGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLSYIVSYYLRNFDED 1549
            +L ++LA GNYMN  +  RG   GF L  L  L D KS+D  ++LL     +Y+ N  ++
Sbjct: 821  ILEIILALGNYMN--SSKRGAVYGFKLQSLDLLLDTKSTDRKQTLL-----HYISNVVKE 873

Query: 1550 AGKEQCLFPLPEPQDLFQASQMKFEDFQKDLRKLKKDLKACEVEAGKVYQVSSKEH-MQP 1608
               +  LF   E   + +A+ +  E+   D+++L++ +            ++ +E+ M  
Sbjct: 874  KYHQVSLF-YNELHYVEKAAAVSLENVLLDVKELQRGM-----------DLTKREYTMHD 921

Query: 1609 FKENMEQFIIQAKIDQEAEENSLTETHKCFLETTAYFFMKPKLGEKEVSPNAFFSIWHEF 1668
                +++FI+  +   +  ++        F +   YF   P    K   P+ FF ++  F
Sbjct: 922  HNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGENP----KTTPPSVFFPVFVRF 977

Query: 1669 SSDFK-----DFWKKENKLLLQERVKEAEEVCRQKKGKSLYKIKPRHDS 1712
               +K     +  +K+ +  L E++ E E +  Q+  KS     P H S
Sbjct: 978  VKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDPKS-----PSHKS 1021



 Score = 81.3 bits (199), Expect = 8e-15
 Identities = 52/119 (43%), Positives = 58/119 (48%), Gaps = 34/119 (28%)

Query: 927  PGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGI 986
            P  G     PLP    PPPPPLP ++  P     G   P+ PP+P    PPPPP      
Sbjct: 516  PTMGAASSGPLP----PPPPPLPPSSDTPETVQNG---PVTPPMP----PPPPP------ 558

Query: 987  PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG---IPPPPPLPGAGIPPPPPLPGAGIP 1042
            PPPPP      PPPPP      PPPPPLPG     +P PP  P   +P  PPLPG   P
Sbjct: 559  PPPPP------PPPPP------PPPPPLPGPAAETVPAPPLAPP--LPSAPPLPGTSSP 603



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 54/118 (45%), Positives = 55/118 (46%), Gaps = 32/118 (27%)

Query: 971  PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1030
            P  G     PLP    PPPPPLP +   P     G   PP PP P    PPPPP P    
Sbjct: 516  PTMGAASSGPLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP---- 563

Query: 1031 PPPPPLPGAGIPPPPPLPG--AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1086
            PPPPP      PPPPPLPG  A   P PPL        PPLP A     PPLPG   P
Sbjct: 564  PPPPP------PPPPPLPGPAAETVPAPPLA-------PPLPSA-----PPLPGTSSP 603



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 54/118 (45%), Positives = 55/118 (46%), Gaps = 32/118 (27%)

Query: 982  PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1041
            P  G     PLP    PPPPPLP +   P     G   PP PP P    PPPPP P    
Sbjct: 516  PTMGAASSGPLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP---- 563

Query: 1042 PPPPPLPGAGIPPPPPLPG--AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1097
            PPPPP      PPPPPLPG  A   P PPL        PPLP A     PPLPG   P
Sbjct: 564  PPPPP------PPPPPLPGPAAETVPAPPLA-------PPLPSA-----PPLPGTSSP 603



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 54/118 (45%), Positives = 55/118 (46%), Gaps = 32/118 (27%)

Query: 993  PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1052
            P  G     PLP    PPPPPLP +   P     G   PP PP P    PPPPP P    
Sbjct: 516  PTMGAASSGPLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP---- 563

Query: 1053 PPPPPLPGAGIPPPPPLPG--AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIP 1108
            PPPPP      PPPPPLPG  A   P PPL        PPLP A     PPLPG   P
Sbjct: 564  PPPPP------PPPPPLPGPAAETVPAPPLA-------PPLPSA-----PPLPGTSSP 603



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 49/108 (45%), Positives = 52/108 (48%), Gaps = 23/108 (21%)

Query: 1015 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1074
            P  G     PLP    PPPPPLP +   P     G   PP PP P    PPPPP P    
Sbjct: 516  PTMGAASSGPLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP---- 563

Query: 1075 PPPPPLPGAGIPPPPPLPGAG---IPPPPPLPGVGIPPPPPLPGAGIP 1119
            PPPPP      PPPPPLPG     +P PP  P   +P  PPLPG   P
Sbjct: 564  PPPPP------PPPPPLPGPAAETVPAPPLAPP--LPSAPPLPGTSSP 603



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 49/108 (45%), Positives = 52/108 (48%), Gaps = 23/108 (21%)

Query: 1037 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1096
            P  G     PLP    PPPPPLP +   P     G   PP PP P    PPPPP P    
Sbjct: 516  PTMGAASSGPLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP---- 563

Query: 1097 PPPPPLPGVGIPPPPPLPGAG---IPPPPPLPGAGIPPPPPLPGAGIP 1141
            PPPPP      PPPPPLPG     +P PP  P   +P  PPLPG   P
Sbjct: 564  PPPPP------PPPPPLPGPAAETVPAPPLAPP--LPSAPPLPGTSSP 603



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 49/108 (45%), Positives = 52/108 (48%), Gaps = 23/108 (21%)

Query: 1059 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGI 1118
            P  G     PLP    PPPPPLP +   P     G   PP PP P    PPPPP P    
Sbjct: 516  PTMGAASSGPLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP---- 563

Query: 1119 PPPPPLPGAGIPPPPPLPGAG---IPPPPPLPRVGIPPPPPLPGAGIP 1163
            PPPPP      PPPPPLPG     +P PP  P   +P  PPLPG   P
Sbjct: 564  PPPPP------PPPPPLPGPAAETVPAPPLAPP--LPSAPPLPGTSSP 603



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 52/119 (43%), Positives = 56/119 (47%), Gaps = 34/119 (28%)

Query: 1070 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGI 1129
            P  G     PLP    PPPPPLP +   P     G   P  PP+P    PPPPP      
Sbjct: 516  PTMGAASSGPLP----PPPPPLPPSSDTPETVQNG---PVTPPMP----PPPPP------ 558

Query: 1130 PPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAG---IPPPPPLPGAGIPPPPPLPGVGIP 1185
            PPPPP      PPPPP      PPPPPLPG     +P PP  P   +P  PPLPG   P
Sbjct: 559  PPPPP------PPPPP------PPPPPLPGPAAETVPAPPLAPP--LPSAPPLPGTSSP 603



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 49/108 (45%), Positives = 52/108 (48%), Gaps = 23/108 (21%)

Query: 1092 PGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGI 1151
            P  G     PLP    PPPPPLP +   P     G   PP PP P    PPPPP P    
Sbjct: 516  PTMGAASSGPLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP---- 563

Query: 1152 PPPPPLPGAGIPPPPPLPGAG---IPPPPPLPGVGIPPPPPLPGVGIP 1196
            PPPPP      PPPPPLPG     +P PP  P   +P  PPLPG   P
Sbjct: 564  PPPPP------PPPPPLPGPAAETVPAPPLAPP--LPSAPPLPGTSSP 603



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 49/108 (45%), Positives = 52/108 (48%), Gaps = 23/108 (21%)

Query: 960  PGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1019
            P  G     PLP    PPPPPLP +   P     G   PP PP P    PPPPP P    
Sbjct: 516  PTMGAASSGPLP----PPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPPPP---- 563

Query: 1020 PPPPPLPGAGIPPPPPLPGAG---IPPPPPLPGAGIPPPPPLPGAGIP 1064
            PPPPP      PPPPPLPG     +P PP  P   +P  PPLPG   P
Sbjct: 564  PPPPP------PPPPPLPGPAAETVPAPPLAPP--LPSAPPLPGTSSP 603



 Score = 77.8 bits (190), Expect = 8e-14
 Identities = 51/114 (44%), Positives = 56/114 (49%), Gaps = 34/114 (29%)

Query: 874 GMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILP 933
           G +PPPPPPLP       PS+  P+   +Q   + PP PPP P    PPPPP P      
Sbjct: 524 GPLPPPPPPLP-------PSSDTPET--VQNGPVTPPMPPPPP----PPPPPPP------ 564

Query: 934 LPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIP 987
            PP P    PPPPPLPG A    P       PL PPLP A     PPLPG   P
Sbjct: 565 -PPPP----PPPPPLPGPAAETVP-----APPLAPPLPSA-----PPLPGTSSP 603



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 54/137 (39%), Positives = 57/137 (41%), Gaps = 44/137 (32%)

Query: 1038 GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1097
            G  + P      +G  P         PPPPPLP +   P     G   PP PP P    P
Sbjct: 511  GNSVGPTMGAASSGPLP---------PPPPPLPPSSDTPETVQNGPVTPPMPPPP----P 557

Query: 1098 PPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPL 1157
            PPPP P    PPPPP      PPPPPLPG         P A   P PPL        PPL
Sbjct: 558  PPPPPP----PPPPP------PPPPPLPG---------PAAETVPAPPL-------APPL 591

Query: 1158 PGAGIPPPPPLPGAGIP 1174
            P A     PPLPG   P
Sbjct: 592  PSA-----PPLPGTSSP 603



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 50/124 (40%), Positives = 52/124 (41%), Gaps = 46/124 (37%)

Query: 908  LPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLP 967
            LPPPPPPLP +   P     G    P+PP P    PPPPP      PPPPP         
Sbjct: 526  LPPPPPPLPPSSDTPETVQNGPVTPPMPPPP----PPPPP------PPPPP--------- 566

Query: 968  PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1027
                    PPPPP       PP P P A   P PPL        PPLP A     PPLPG
Sbjct: 567  --------PPPPP-------PPLPGPAAETVPAPPL-------APPLPSA-----PPLPG 599

Query: 1028 AGIP 1031
               P
Sbjct: 600  TSSP 603



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 47/112 (41%), Positives = 50/112 (44%), Gaps = 38/112 (33%)

Query: 856 PSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPL 915
           P PPPLP +  +      G V PP PP P            P PPP       PPPPPP 
Sbjct: 528 PPPPPLPPSSDTPETVQNGPVTPPMPPPP------------PPPPP-------PPPPPP- 567

Query: 916 PGAGIPPPPPLPG--AGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIP 965
                PPPPPLPG  A  +P PPL        PPLP A     PPLPG   P
Sbjct: 568 ----PPPPPPLPGPAAETVPAPPL-------APPLPSA-----PPLPGTSSP 603



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 72/292 (24%), Positives = 110/292 (37%), Gaps = 78/292 (26%)

Query: 638 LEDAETESQSAVSETPQKRSDAVQKEVVDMKSEGQATVIQQLEQTIEDLRTKIAELERQY 697
           LEDAET++ +               E V+   E  + + ++L+ T  +  +KI ELE+Q 
Sbjct: 382 LEDAETKNAAL--------------ERVEELEENISHLSEKLQDTENEAMSKIVELEKQL 427

Query: 698 PALDTEVASGHQGLENGVTASGDVCLEALRLEEKEVRHHRILEAK--------SIQTSPT 749
              + E+    +  ++  T    +  + ++ +E+ ++    LE K        +I+    
Sbjct: 428 MQRNKELDVVREIYKDANTQVHTL-RKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKK 486

Query: 750 EEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQ 809
            +G +  LP V              SG      S  S +V+   +   + +     S   
Sbjct: 487 GDGDIAILPVV-------------ASGT----LSMGSEVVAGNSVGPTMGA---ASSGPL 526

Query: 810 PPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSS 869
           PPPPP L        P S  P ++                    N P  PP+P       
Sbjct: 527 PPPPPPL-------PPSSDTPETVQ-------------------NGPVTPPMPPPPPPPP 560

Query: 870 MPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIP 921
            P     PPPPPPLPG    T+P  A P  PPL       P  PPLPG   P
Sbjct: 561 PPPPPPPPPPPPPLPGPAAETVP--APPLAPPL-------PSAPPLPGTSSP 603



 Score = 37.4 bits (85), Expect = 0.13
 Identities = 23/77 (29%), Positives = 30/77 (38%), Gaps = 1/77 (1%)

Query: 254 LGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAPSLPAAQPA 313
           +GP+ GA  +   P     L   SD PE++   P  P  PP P   P    P  P   P 
Sbjct: 514 VGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPP-PPPPPPPPPPPPPP 572

Query: 314 AKDSPSSTAFPFPEAGP 330
               P++   P P   P
Sbjct: 573 PLPGPAAETVPAPPLAP 589


>gi|148536848 carboxyl ester lipase precursor [Homo sapiens]
          Length = 756

 Score =  155 bits (391), Expect = 4e-37
 Identities = 77/192 (40%), Positives = 92/192 (47%)

Query: 932  LPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPP 991
            L LP +      P PP   +   P PP   +     PP   +G PP PP   +G PP PP
Sbjct: 550  LALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPP 609

Query: 992  LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1051
               +G PP PP   +G PP PP   +G PP PP   +G PP PP   +G PP PP   +G
Sbjct: 610  TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG 669

Query: 1052 IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPP 1111
             PP PP   AG PP PP   +G PP PP   +G PP  P   +   P PP    G PP P
Sbjct: 670  APPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVP 729

Query: 1112 PLPGAGIPPPPP 1123
            P   +   P PP
Sbjct: 730  PTGDSEAAPVPP 741



 Score =  154 bits (389), Expect = 7e-37
 Identities = 75/180 (41%), Positives = 88/180 (48%)

Query: 977  PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1036
            P PP   +   P PP   +   P PP   +G PP PP   +G PP PP   +G PP PP 
Sbjct: 562  PVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 621

Query: 1037 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1096
              +G PP PP   +G PP PP   +G PP PP   +G PP PP   +G PP PP   AG 
Sbjct: 622  GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGP 681

Query: 1097 PPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPP 1156
            PP PP    G PP PP   +G PP  P   +   P PP   +G PP PP       P PP
Sbjct: 682  PPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 741



 Score =  154 bits (389), Expect = 7e-37
 Identities = 75/180 (41%), Positives = 88/180 (48%)

Query: 999  PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1058
            P PP   +   P PP   +   P PP   +G PP PP   +G PP PP   +G PP PP 
Sbjct: 562  PVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 621

Query: 1059 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGI 1118
              +G PP PP   +G PP PP   +G PP PP   +G PP PP    G PP PP   AG 
Sbjct: 622  GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGP 681

Query: 1119 PPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1178
            PP PP   +G PP PP   +G PP  P       P PP   +G PP PP   +   P PP
Sbjct: 682  PPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 741



 Score =  154 bits (388), Expect = 9e-37
 Identities = 74/180 (41%), Positives = 88/180 (48%)

Query: 988  PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1047
            P PP   +   P PP   +   P PP   +G PP PP   +G PP PP   +G PP PP 
Sbjct: 562  PVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 621

Query: 1048 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGI 1107
              +G PP PP   +G PP PP   +G PP PP   +G PP PP   +G PP PP    G 
Sbjct: 622  GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGP 681

Query: 1108 PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPP 1167
            PP PP   +G PP PP   +G PP  P   +   P PP    G PP PP   +   P PP
Sbjct: 682  PPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 741



 Score =  154 bits (388), Expect = 9e-37
 Identities = 74/178 (41%), Positives = 88/178 (49%)

Query: 968  PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1027
            PP   +   P PP   +   P PP   +G PP PP   +G PP PP   +G PP PP   
Sbjct: 564  PPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGD 623

Query: 1028 AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1087
            +G PP PP   +G PP PP   +G PP PP   +G PP PP   +G PP PP   AG PP
Sbjct: 624  SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPP 683

Query: 1088 PPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1145
             PP   +G PP PP    G PP  P   +   P PP   +G PP PP   +   P PP
Sbjct: 684  VPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 741



 Score =  153 bits (386), Expect = 2e-36
 Identities = 76/183 (41%), Positives = 90/183 (49%), Gaps = 1/183 (0%)

Query: 952  AIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1011
            A P PP       P+PP    +   P PP   +G PP PP   +G PP PP   +G PP 
Sbjct: 560  ATPVPPTGDSEATPVPPT-GDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV 618

Query: 1012 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1071
            PP   +G PP PP   +G PP PP   +G PP PP   +G PP PP   +G PP PP   
Sbjct: 619  PPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGD 678

Query: 1072 AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPP 1131
            AG PP PP   +G PP PP   +G PP  P       P PP   +G PP PP   +   P
Sbjct: 679  AGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAP 738

Query: 1132 PPP 1134
             PP
Sbjct: 739  VPP 741



 Score =  153 bits (386), Expect = 2e-36
 Identities = 75/180 (41%), Positives = 87/180 (48%)

Query: 1010 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1069
            P PP   +   P PP   +   P PP   +G PP PP   +G PP PP   +G PP PP 
Sbjct: 562  PVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 621

Query: 1070 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGI 1129
              +G PP PP   +G PP PP   +G PP PP    G PP PP   +G PP PP   AG 
Sbjct: 622  GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGP 681

Query: 1130 PPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPP 1189
            PP PP   +G PP PP    G PP  P   +   P PP   +G PP PP       P PP
Sbjct: 682  PPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 741



 Score =  152 bits (385), Expect = 2e-36
 Identities = 74/186 (39%), Positives = 91/186 (48%)

Query: 905  TEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGI 964
            T+    P PP   +   P PP   +   P+PP   +G PP PP   +  PP PP   +G 
Sbjct: 556  TDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA 615

Query: 965  PLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1024
            P  PP   +G PP PP   +G PP PP   +G PP PP   +G PP PP   +G PP PP
Sbjct: 616  PPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPP 675

Query: 1025 LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1084
               AG PP PP   +G PP PP   +G PP  P   +   P PP   +G PP PP   + 
Sbjct: 676  TGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSE 735

Query: 1085 IPPPPP 1090
              P PP
Sbjct: 736  AAPVPP 741



 Score =  152 bits (383), Expect = 4e-36
 Identities = 73/180 (40%), Positives = 89/180 (49%)

Query: 922  PPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPL 981
            P PP   +   P+PP   +   P PP   +  PP PP   +G P  PP   +G PP PP 
Sbjct: 562  PVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 621

Query: 982  PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1041
              +G PP PP   +G PP PP   +G PP PP   +G PP PP   +G PP PP   AG 
Sbjct: 622  GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGP 681

Query: 1042 PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1101
            PP PP   +G PP PP   +G PP  P   +   P PP   +G PP PP   +   P PP
Sbjct: 682  PPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 741



 Score =  152 bits (383), Expect = 4e-36
 Identities = 75/180 (41%), Positives = 86/180 (47%)

Query: 1021 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1080
            P PP   +   P PP   +   P PP   +G PP PP   +G PP PP   +G PP PP 
Sbjct: 562  PVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 621

Query: 1081 PGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1140
              +G PP PP   +G PP PP    G PP PP   +G PP PP   +G PP PP   AG 
Sbjct: 622  GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGP 681

Query: 1141 PPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPP 1200
            PP PP    G PP PP   +G PP  P   +   P PP    G PP PP       P PP
Sbjct: 682  PPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 741



 Score =  151 bits (382), Expect = 5e-36
 Identities = 74/180 (41%), Positives = 86/180 (47%)

Query: 1032 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1091
            P PP   +   P PP   +   P PP   +G PP PP   +G PP PP   +G PP PP 
Sbjct: 562  PVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 621

Query: 1092 PGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGI 1151
              +G PP PP    G PP PP   +G PP PP   +G PP PP   +G PP PP    G 
Sbjct: 622  GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGP 681

Query: 1152 PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPP 1211
            PP PP   +G PP PP   +G PP  P       P PP    G PP PP   +   P PP
Sbjct: 682  PPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 741



 Score =  149 bits (376), Expect = 2e-35
 Identities = 74/179 (41%), Positives = 84/179 (46%)

Query: 1043 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1102
            P PP   +   P PP   +   P PP   +G PP PP   +G PP PP   +G PP PP 
Sbjct: 562  PVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 621

Query: 1103 PGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGI 1162
               G PP PP   +G PP PP   +G PP PP   +G PP PP    G PP PP   AG 
Sbjct: 622  GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGP 681

Query: 1163 PPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAP 1221
            PP PP   +G PP PP    G PP  P       P PP   +G PP PP       P P
Sbjct: 682  PPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVP 740



 Score =  144 bits (364), Expect = 6e-34
 Identities = 75/195 (38%), Positives = 94/195 (48%), Gaps = 4/195 (2%)

Query: 886  MTVPTLPST-AIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPP 944
            + +PT+    A P PP     +    P PP   +   P PP   +G  P+PP   +G PP
Sbjct: 550  LALPTVTDQEATPVPPT---GDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPP 606

Query: 945  PPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1004
             PP   +  PP PP   +G P  PP   +G PP PP   +G PP PP   +G PP PP  
Sbjct: 607  VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 666

Query: 1005 GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1064
             +G PP PP   AG PP PP   +G PP PP   +G PP  P   +   P PP   +G P
Sbjct: 667  DSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAP 726

Query: 1065 PPPPLPGAGIPPPPP 1079
            P PP   +   P PP
Sbjct: 727  PVPPTGDSEAAPVPP 741



 Score =  142 bits (357), Expect = 4e-33
 Identities = 76/181 (41%), Positives = 86/181 (47%), Gaps = 8/181 (4%)

Query: 1054 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPL 1113
            P PP   +   P PP   +   P PP   +G PP PP   +G PP PP    G PP PP 
Sbjct: 562  PVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 621

Query: 1114 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPG-AG 1172
              +G PP PP   +G PP PP   +G PP PP    G PP PP   +G PP PP  G AG
Sbjct: 622  GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT-GDAG 680

Query: 1173 IPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAP------APPLP 1226
             PP PP    G PP PP    G PP  P   +   P PP    G PP P      A P+P
Sbjct: 681  PPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVP 740

Query: 1227 P 1227
            P
Sbjct: 741  P 741



 Score =  135 bits (341), Expect = 3e-31
 Identities = 77/200 (38%), Positives = 92/200 (46%), Gaps = 7/200 (3%)

Query: 1065 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPL 1124
            P PP   +   P PP   +   P PP   +G PP PP    G PP PP   +G PP PP 
Sbjct: 562  PVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 621

Query: 1125 PGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGI 1184
              +G PP PP   +G PP PP    G PP PP   +G PP PP   +G PP PP    G 
Sbjct: 622  GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPP---TGD 678

Query: 1185 PPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPG-TGIPP-PPLLPVSG 1242
              PPP+P  G    PP+P  G    PP+   G   +   P+PP G +G PP PP      
Sbjct: 679  AGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTG--DSETAPVPPTGDSGAPPVPPTGDSEA 736

Query: 1243 PPLLPQVGSSTLPTPQVCGF 1262
             P+ P   S     P V  F
Sbjct: 737  APVPPTDDSKEAQMPAVIRF 756



 Score =  135 bits (339), Expect = 4e-31
 Identities = 74/197 (37%), Positives = 89/197 (45%), Gaps = 7/197 (3%)

Query: 861  LPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGI 920
            LP      + P    VPP          PT  S   P PP     +   PP PP   +G 
Sbjct: 552  LPTVTDQEATP----VPPTGDSEATPVPPTGDSETAPVPPT---GDSGAPPVPPTGDSGA 604

Query: 921  PPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPP 980
            PP PP   +G  P+PP   +G PP PP   +  PP PP   +G P  PP   +G PP PP
Sbjct: 605  PPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPP 664

Query: 981  LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1040
               +G PP PP   AG PP PP   +G PP PP   +G PP  P   +   P PP   +G
Sbjct: 665  TGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSG 724

Query: 1041 IPPPPPLPGAGIPPPPP 1057
             PP PP   +   P PP
Sbjct: 725  APPVPPTGDSEAAPVPP 741



 Score =  132 bits (333), Expect = 2e-30
 Identities = 72/182 (39%), Positives = 81/182 (44%), Gaps = 14/182 (7%)

Query: 1087 PPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1146
            P PP   +   P PP       P PP   +G PP PP   +G PP PP   +G PP PP 
Sbjct: 562  PVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 621

Query: 1147 PRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGI 1206
               G PP PP   +G PP PP   +G PP PP    G PP PP    G PP PP   AG 
Sbjct: 622  GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGP 681

Query: 1207 PPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPP 1266
            PP PP    G     APP+PP G             PP+ P   S T P P       PP
Sbjct: 682  PPVPPTGDSG-----APPVPPTGDS---------GAPPVTPTGDSETAPVPPTGDSGAPP 727

Query: 1267 LP 1268
            +P
Sbjct: 728  VP 729



 Score =  129 bits (324), Expect = 2e-29
 Identities = 72/187 (38%), Positives = 87/187 (46%), Gaps = 7/187 (3%)

Query: 860  PLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAG 919
            P+P T  S + P    VPP          PT  S A P PP     +   PP PP   +G
Sbjct: 562  PVPPTGDSEATP----VPPTGDSETAPVPPTGDSGAPPVPPT---GDSGAPPVPPTGDSG 614

Query: 920  IPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPP 979
             PP PP   +G  P+PP   +G PP PP   +  PP PP   +G P  PP   +G PP P
Sbjct: 615  APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP 674

Query: 980  PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA 1039
            P   AG PP PP   +G PP PP   +G PP  P   +   P PP   +G PP PP   +
Sbjct: 675  PTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDS 734

Query: 1040 GIPPPPP 1046
               P PP
Sbjct: 735  EAAPVPP 741



 Score =  107 bits (266), Expect = 1e-22
 Identities = 62/168 (36%), Positives = 78/168 (46%), Gaps = 3/168 (1%)

Query: 859  PPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGT-EMLPPPPPPLPG 917
            PP   +E++   P      PP PP      P +P T     PP+  T +   PP PP   
Sbjct: 575  PPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGD 634

Query: 918  AGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPG-AGIPLPPPLPGAGIP 976
            +G PP PP   +G  P+PP   +G PP PP   +  PP PP  G AG P  PP   +G P
Sbjct: 635  SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT-GDAGPPPVPPTGDSGAP 693

Query: 977  PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1024
            P PP   +G PP  P   +   P PP   +G PP PP   +   P PP
Sbjct: 694  PVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 741



 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 67/252 (26%), Positives = 87/252 (34%), Gaps = 78/252 (30%)

Query: 740 EAKSIQTSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLD 799
           ++++    PT +     +PP  G  G PP PP  +SG                       
Sbjct: 568 DSEATPVPPTGDSETAPVPPT-GDSGAPPVPPTGDSGAPPV------------------- 607

Query: 800 SHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPP 859
              PT     PP PP+       G  G+                               P
Sbjct: 608 --PPTGDSGAPPVPPT-------GDSGA-------------------------------P 627

Query: 860 PLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAG 919
           P+P T  S +           PP+P    PT  S A P PP     +   PP PP   +G
Sbjct: 628 PVPPTGDSGA-----------PPVP----PTGDSGAPPVPPT---GDSGAPPVPPTGDSG 669

Query: 920 IPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPP 979
            PP PP   AG  P+PP   +G PP PP   +  PP  P   +     PP   +G PP P
Sbjct: 670 APPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVP 729

Query: 980 PLPGAGIPPPPP 991
           P   +   P PP
Sbjct: 730 PTGDSEAAPVPP 741



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 36/101 (35%), Positives = 43/101 (42%), Gaps = 11/101 (10%)

Query: 1179 LPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMG---IPPAP------APPLPPPG 1229
            LP V      P+P  G     P+P  G     P+P  G    PP P      APP+PP G
Sbjct: 552  LPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTG 611

Query: 1230 -TGIPPPPLLPVSGPPLLPQVG-SSTLPTPQVCGFLPPPLP 1268
             +G PP P    SG P +P  G S   P P       PP+P
Sbjct: 612  DSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP 652


>gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens]
          Length = 464

 Score =  155 bits (391), Expect = 4e-37
 Identities = 118/302 (39%), Positives = 141/302 (46%), Gaps = 67/302 (22%)

Query: 877  PPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPP 936
            PP PP LP       P    P PP + G     PP PPLP + +PPPPP    G LPLPP
Sbjct: 217  PPAPPSLPAGP----PGVKRPPPPLMNGL----PPRPPLPES-LPPPPP----GGLPLPP 263

Query: 937  LPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPL---PGAGIPPPPPLPGAGIPPPPPLP 993
            +P  G P P   PG   PP  P P  G+  P P+   P +G+ PP P    G+ PP P  
Sbjct: 264  MPPTG-PAPSGPPG---PPQLPPPAPGVHPPAPVVHPPASGVHPPAP----GVHPPAP-- 313

Query: 994  GAGIPPPPP---LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA 1050
              G+ PP P    P +G+ PP P    G+ PP P    G+ PP P    G+ PP P    
Sbjct: 314  --GVHPPAPGVHPPTSGVHPPAP----GVHPPAP----GVHPPAP----GVHPPAP---- 355

Query: 1051 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP-PPPLPGAGIPPP---PPLPGVG 1106
            G+ PP P    G+ PP   P AG+ P  P      P   P  PG   P P   P  PGV 
Sbjct: 356  GVHPPAP----GVHPP---PSAGVHPQAPGVHPAAPAVHPQAPGVHPPAPGMHPQAPGVH 408

Query: 1107 IPPPPPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPP 1165
              PP   P A G+ P PP    G+ P  P    G+ PP P+P +  PP P      IPPP
Sbjct: 409  PQPPGVHPSAPGVHPQPP----GVHPSNP----GVHPPTPMPPMLRPPLPSEGPGNIPPP 460

Query: 1166 PP 1167
            PP
Sbjct: 461  PP 462



 Score =  154 bits (389), Expect = 7e-37
 Identities = 118/289 (40%), Positives = 141/289 (48%), Gaps = 62/289 (21%)

Query: 909  PPPPPPLPGAGIP----PPPPLPGAGILPLPPLPGAGIPPPPP--LPGAAIPPPPPLPGA 962
            PP PP LP AG P    PPPPL   G+ P PPLP + +PPPPP  LP   +PP  P P +
Sbjct: 217  PPAPPSLP-AGPPGVKRPPPPLMN-GLPPRPPLPES-LPPPPPGGLPLPPMPPTGPAP-S 272

Query: 963  GIPLPP--PLPGAGIPPPPPL---PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP---L 1014
            G P PP  P P  G+ PP P+   P +G+ PP P    G+ PP P    G+ PP P    
Sbjct: 273  GPPGPPQLPPPAPGVHPPAPVVHPPASGVHPPAP----GVHPPAP----GVHPPAPGVHP 324

Query: 1015 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1074
            P +G+ PP P    G+ PP P    G+ PP P    G+ PP P    G+ PP P    G+
Sbjct: 325  PTSGVHPPAP----GVHPPAP----GVHPPAP----GVHPPAP----GVHPPAP----GV 364

Query: 1075 PPPPPLPGAGIPPPPPLPGAGIPP-PPPLPGVGIPPP---PPLPGAGIPPPPPLPGA-GI 1129
             PP   P AG+ P  P      P   P  PGV  P P   P  PG    PP   P A G+
Sbjct: 365  HPP---PSAGVHPQAPGVHPAAPAVHPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPGV 421

Query: 1130 PPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1178
             P PP    G+ P  P    G+ PP P+P    PP P      IPPPPP
Sbjct: 422  HPQPP----GVHPSNP----GVHPPTPMPPMLRPPLPSEGPGNIPPPPP 462



 Score =  150 bits (378), Expect = 1e-35
 Identities = 112/269 (41%), Positives = 129/269 (47%), Gaps = 56/269 (20%)

Query: 976  PPPPPLPGAGIP----PPPPLPGAGIPPPPPLPGAGIPPPPP--LPGAGIPPPPPLPGAG 1029
            PP PP   AG P    PPPPL   G+PP PPLP + +PPPPP  LP   +PP  P P +G
Sbjct: 217  PPAPPSLPAGPPGVKRPPPPLMN-GLPPRPPLPES-LPPPPPGGLPLPPMPPTGPAP-SG 273

Query: 1030 IPPPP--PLPGAGIPPPPPL---PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1084
             P PP  P P  G+ PP P+   P +G+ PP P    G+ PP P    G+ PP P    G
Sbjct: 274  PPGPPQLPPPAPGVHPPAPVVHPPASGVHPPAP----GVHPPAP----GVHPPAP----G 321

Query: 1085 IPPP-----PPLPGAGIPPP---PPLPGVGIPPP---PPLPGAGIPPP----PPLPGAGI 1129
            + PP     PP PG   P P   PP PGV  P P   PP PG   PP     P  PG   
Sbjct: 322  VHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPPSAGVHPQAPGVHP 381

Query: 1130 PPP---PPLPGAGIPPP---PPLPRVGIPPPPPLPGA-GIPPPPPLPGAGIPPPPPLPGV 1182
              P   P  PG   P P   P  P V   PP   P A G+ P PP    G+ P  P    
Sbjct: 382  AAPAVHPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPGVHPQPP----GVHPSNP---- 433

Query: 1183 GIPPPPPLPGVGIPPPPPLPGAGIPPPPP 1211
            G+ PP P+P +  PP P      IPPPPP
Sbjct: 434  GVHPPTPMPPMLRPPLPSEGPGNIPPPPP 462



 Score =  146 bits (369), Expect = 1e-34
 Identities = 115/281 (40%), Positives = 131/281 (46%), Gaps = 67/281 (23%)

Query: 987  PPPPPLPGAGIP----PPPPLPGAGIPPPPPLPGAGIPPPPP--LPGAGIPPPPPLPGAG 1040
            PP PP   AG P    PPPPL   G+PP PPLP + +PPPPP  LP   +PP  P P +G
Sbjct: 217  PPAPPSLPAGPPGVKRPPPPLMN-GLPPRPPLPES-LPPPPPGGLPLPPMPPTGPAP-SG 273

Query: 1041 IPPPP--PLPGAGIPPPPPL---PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1095
             P PP  P P  G+ PP P+   P +G+ PP P    G+ PP P    G+ PP P    G
Sbjct: 274  PPGPPQLPPPAPGVHPPAPVVHPPASGVHPPAP----GVHPPAP----GVHPPAP----G 321

Query: 1096 IPPP-----PPLPGVGIPPP---PPLPGAGIPPP---PPLPGAGIPPPPPLPGAGIPPPP 1144
            + PP     PP PGV  P P   PP PG   P P   PP PG  + PPP    AG+ P  
Sbjct: 322  VHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPG--VHPPP---SAGVHPQA 376

Query: 1145 PLPRVGIPPP-PPLPGAGIPPP---PPLPGAGIPPP---PPLPGVGIPPPPPLPG-VGIP 1196
            P      P   P  PG   P P   P  PG    PP   P  PGV   PP   P   G+ 
Sbjct: 377  PGVHPAAPAVHPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPGVHPQPPGVHPSNPGVH 436

Query: 1197 PPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPPGTG-IPPPP 1236
            PP P+                PP   PPLP  G G IPPPP
Sbjct: 437  PPTPM----------------PPMLRPPLPSEGPGNIPPPP 461



 Score =  139 bits (349), Expect = 3e-32
 Identities = 106/260 (40%), Positives = 124/260 (47%), Gaps = 49/260 (18%)

Query: 1031 PPPPPLPGAGIP----PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1086
            PP PP   AG P    PPPPL   G+PP PPLP + +PPPPP    G  P PP+P  G P
Sbjct: 217  PPAPPSLPAGPPGVKRPPPPLMN-GLPPRPPLPES-LPPPPP----GGLPLPPMPPTG-P 269

Query: 1087 PPPPLPGAGIPPPPPLPGVGIPPPPPL---PGAGIPPPPP---LPGAGIPPPPP---LPG 1137
             P   PG   PP  P P  G+ PP P+   P +G+ PP P    P  G+ PP P    P 
Sbjct: 270  APSGPPG---PPQLPPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPT 326

Query: 1138 AGIPPPPPLPRVGIPPP-----PPLPGAGIPPP---PPLPGAGIPPP----PPLPGVGIP 1185
            +G+ PP P    G+ PP     PP PG   P P   PP PG   PP     P  PGV   
Sbjct: 327  SGVHPPAP----GVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPPSAGVHPQAPGVHPA 382

Query: 1186 PP---PPLPGVGIPPP---PPLPGAGIPPPPPLPGM-GIPPAPAPPLPPPGTGI-PPPPL 1237
             P   P  PGV  P P   P  PG    PP   P   G+ P P P + P   G+ PP P+
Sbjct: 383  APAVHPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPGVHPQP-PGVHPSNPGVHPPTPM 441

Query: 1238 LPVSGPPLLPQVGSSTLPTP 1257
             P+  PP LP  G   +P P
Sbjct: 442  PPMLRPP-LPSEGPGNIPPP 460



 Score =  107 bits (266), Expect = 1e-22
 Identities = 96/288 (33%), Positives = 114/288 (39%), Gaps = 54/288 (18%)

Query: 807  ISQPPPPPSLLWSAGQGQPG-SQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTE 865
            + +PP PPSL      G PG  +PP  +            S        +P PP  P   
Sbjct: 214  MEKPPAPPSL----PAGPPGVKRPPPPLMNGLPPRPPLPESLPPPPPGGLPLPPMPPTGP 269

Query: 866  SSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPP---PPLPGAGIPP 922
            + S  PG   +PPP P +        P   +  PP    + + PP P   PP PG   P 
Sbjct: 270  APSGPPGPPQLPPPAPGVH-------PPAPVVHPP---ASGVHPPAPGVHPPAPGVHPPA 319

Query: 923  P---PPLPGAGILPLPPLPGAGIPPP---PPLPGAAIPPP---PPLPGAGIPLPPPLPGA 973
            P   PP  G      PP PG   P P   PP PG   P P   PP PG       P P A
Sbjct: 320  PGVHPPTSGVH----PPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPGV-----HPPPSA 370

Query: 974  GIPPPPPLPGAGIPP-PPPLPGAGIPPPPPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIP 1031
            G+ P  P      P   P  PG   P P   P A G+ P PP    G+ P  P    G+ 
Sbjct: 371  GVHPQAPGVHPAAPAVHPQAPGVHPPAPGMHPQAPGVHPQPP----GVHPSAP----GVH 422

Query: 1032 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1079
            P PP    G+ P  P    G+ PP P+P    PP P      IPPPPP
Sbjct: 423  PQPP----GVHPSNP----GVHPPTPMPPMLRPPLPSEGPGNIPPPPP 462



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 103/338 (30%), Positives = 124/338 (36%), Gaps = 101/338 (29%)

Query: 735  HHRILEAKSIQTSPTEEGGVLTLPP--VDGLPGRPPCPPGAESGPQTKFCSEISLIVSPR 792
            H ++ +  +  + P    GV   PP  ++GLP RPP P   ES P               
Sbjct: 211  HFKMEKPPAPPSLPAGPPGVKRPPPPLMNGLPPRPPLP---ESLPP-------------- 253

Query: 793  RISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNS 852
                      P   +  PP PP+    +G   P   PP                      
Sbjct: 254  ---------PPPGGLPLPPMPPTGPAPSGPPGPPQLPP---------------------- 282

Query: 853  CNIPSP---PPLPCTESSSSMPGLGMVPPPP---PPLPGMTVPTLPSTAIPQPPPLQGTE 906
               P+P   PP P        P  G+ PP P   PP PG+  P     A    PP  G  
Sbjct: 283  ---PAPGVHPPAPVVHP----PASGVHPPAPGVHPPAPGVHPP-----APGVHPPTSGVH 330

Query: 907  MLPPPP---PPLPGAGIPPP---PPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLP 960
              PP P   PP PG   P P   PP PG      PP PG     PPP  G   P  P + 
Sbjct: 331  --PPAPGVHPPAPGVHPPAPGVHPPAPGVH----PPAPGV---HPPPSAGVH-PQAPGVH 380

Query: 961  GAGIPLPPPLPGAGIPPPPPLPGA-GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 1019
             A   + P  PG   P P   P A G+ P PP    G+ P  P    G+ P PP    G+
Sbjct: 381  PAAPAVHPQAPGVHPPAPGMHPQAPGVHPQPP----GVHPSAP----GVHPQPP----GV 428

Query: 1020 PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1057
             P  P    G+ PP P+P    PP P      IPPPPP
Sbjct: 429  HPSNP----GVHPPTPMPPMLRPPLPSEGPGNIPPPPP 462



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 71/171 (41%), Positives = 84/171 (49%), Gaps = 31/171 (18%)

Query: 1108 PPPPPLPGAGIP----PPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIP 1163
            PP PP   AG P    PPPPL   G+PP PPLP + +PPPPP    G  P PP+P  G  
Sbjct: 217  PPAPPSLPAGPPGVKRPPPPLMN-GLPPRPPLPES-LPPPPP----GGLPLPPMPPTGPA 270

Query: 1164 PPPPLPGAGIPPPPPLPGVGIPPPPPL---PGVGIPPPPPLPGAGIPPPPPLPGMGIPPA 1220
            P  P PG   PP  P P  G+ PP P+   P  G+ PP P    G+ PP P    G+ P 
Sbjct: 271  PSGP-PG---PPQLPPPAPGVHPPAPVVHPPASGVHPPAP----GVHPPAP----GVHP- 317

Query: 1221 PAPPLPPPGTG-IPPPPLLPVSGPPLLPQVGSSTLPTPQV----CGFLPPP 1266
            PAP + PP +G  PP P +    P + P       P P V     G  PPP
Sbjct: 318  PAPGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPP 368



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 35/89 (39%), Positives = 40/89 (44%), Gaps = 25/89 (28%)

Query: 1185 PPPPPLPGVGIPPPPPLPGAGIPPPPPLPGM-GIPPAPAPPLPPPGTGIPPPPLLPV--- 1240
            PP PP     +P  PP  G   PPPP + G+   PP P    PPP  G+P PP+ P    
Sbjct: 217  PPAPP----SLPAGPP--GVKRPPPPLMNGLPPRPPLPESLPPPPPGGLPLPPMPPTGPA 270

Query: 1241 -SGPPLLPQVGSSTLPTPQVCGFLPPPLP 1268
             SGPP  PQ              LPPP P
Sbjct: 271  PSGPPGPPQ--------------LPPPAP 285



 Score = 40.4 bits (93), Expect = 0.015
 Identities = 52/190 (27%), Positives = 59/190 (31%), Gaps = 48/190 (25%)

Query: 230 EEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPRE 289
           E+P APP+                  P+G  G     P     L     LPESL      
Sbjct: 215 EKPPAPPSL-----------------PAGPPGVKRPPPPLMNGLPPRPPLPESLP----- 252

Query: 290 PQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAG--PGEEAAGAPVRGAGDTDE 347
              PP PGGLP+   P +P   PA    P     P P  G  P       P  G      
Sbjct: 253 ---PPPPGGLPL---PPMPPTGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASG------ 300

Query: 348 EGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAA-ASLPGSPAPSQR 406
                    AP   P    AP V   AP   G  P      P AP      PG   P+  
Sbjct: 301 -----VHPPAPGVHPP---APGVHPPAP---GVHPPTSGVHPPAPGVHPPAPGVHPPAPG 349

Query: 407 CFKPYPLITP 416
              P P + P
Sbjct: 350 VHPPAPGVHP 359



 Score = 38.5 bits (88), Expect = 0.057
 Identities = 26/56 (46%), Positives = 29/56 (51%), Gaps = 15/56 (26%)

Query: 1218 PPAPAPPLP--PPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGL 1271
            PPAP P LP  PPG   PPPPL+  +G P          P P +   LPPP P GL
Sbjct: 217  PPAP-PSLPAGPPGVKRPPPPLM--NGLP----------PRPPLPESLPPPPPGGL 259



 Score = 37.4 bits (85), Expect = 0.13
 Identities = 59/230 (25%), Positives = 70/230 (30%), Gaps = 24/230 (10%)

Query: 232 PAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQ 291
           P  P +   P PG   GL    + P+G A   P  P      +     P  +   P    
Sbjct: 245 PPLPESLPPPPPG---GLPLPPMPPTGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASGV 301

Query: 292 QPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEE 351
            PP+PG  P   AP +    P      S    P P   P       P  G          
Sbjct: 302 HPPAPGVHP--PAPGVHPPAPGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHP 359

Query: 352 DAFEDAPRGSPG-EEWAPEVGEDAP----QRLGEEPEEEAQGPDAPAAASLPGSPAPSQR 406
            A    P  S G    AP V   AP    Q  G  P      P AP     P    PS  
Sbjct: 360 PAPGVHPPPSAGVHPQAPGVHPAAPAVHPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAP 419

Query: 407 CFKPYPL-ITPCYIKTTTRQLSSPNHSPSQSPNQSPRIKRRPEPSLSRGS 455
              P P  + P          S+P   P   P   P + R P PS   G+
Sbjct: 420 GVHPQPPGVHP----------SNPGVHP---PTPMPPMLRPPLPSEGPGN 456


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score =  154 bits (388), Expect = 9e-37
 Identities = 133/429 (31%), Positives = 150/429 (34%), Gaps = 63/429 (14%)

Query: 886  MTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPP 945
            +T P+ P+T  P PPP   T + P   P  P      PPP       P PP+     PPP
Sbjct: 1396 ITTPSPPTTT-PSPPPTSTTTLPPTTTPSPPTTTTTTPPPTT----TPSPPITTTTTPPP 1450

Query: 946  -----PPLPGAAIPPP--PPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPP--PPLPGAG 996
                 PP+     PPP   P P    P PP        P PP      PPP   P P   
Sbjct: 1451 TTTPSPPISTTTTPPPTTTPSPPTTTPSPPT-----TTPSPPTTTTTTPPPTTTPSPPTT 1505

Query: 997  IPPPPPLPGAGIP----PPPPLPGAGIPPP--PPLPGAGIPPPPPLPGAGIPP---PPPL 1047
             P  PP     +P    P PP      PPP   P P    P  PP     +PP   P P 
Sbjct: 1506 TPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPP 1565

Query: 1048 PGAGIPPPP---PLPGAGIPPPPPLPGAGIPPP-----PPLPGAGIPPP--PPLPGAGIP 1097
            P     PPP   P P     P PP      PPP     PP      PPP   P P    P
Sbjct: 1566 PTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTP 1625

Query: 1098 PPPPLPGVGIPP---PPPLPGAGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPR--V 1149
              PP     +PP   P P P     PPP   P P     P PP+     PPP   P   +
Sbjct: 1626 ITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPI 1685

Query: 1150 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPP----LPGVGIPPPPPLPGAG 1205
               P PP      P P   P + I           P PPP     P     P PP     
Sbjct: 1686 TTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMT 1745

Query: 1206 IPPP----PPLPGMGIPPAPAPP-LPPPGTGIPPPPLLPV--------SGPPLLPQVGSS 1252
              PP     PL    +PP+  PP   P  T  P  P +P+        SG P   + G  
Sbjct: 1746 TLPPTTTSSPLTTTPLPPSITPPTFSPFSTTTPTTPCVPLCNWTGWLDSGKPNFHKPGGD 1805

Query: 1253 TLPTPQVCG 1261
            T     VCG
Sbjct: 1806 TELIGDVCG 1814



 Score =  134 bits (338), Expect = 6e-31
 Identities = 112/363 (30%), Positives = 124/363 (34%), Gaps = 53/363 (14%)

Query: 936  PLPGAGIPPPPPLPGAAIPPP--PPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLP 993
            P P    P PPP     +PP   P  P      PPP       P PP+     PPP   P
Sbjct: 1399 PSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTT----TPSPPITTTTTPPPTTTP 1454

Query: 994  GAGIPPPPPLPGAGIPPPP--PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP--PLPG 1049
                   PP+     PPP   P P    P PP        P PP      PPP   P P 
Sbjct: 1455 S------PPISTTTTPPPTTTPSPPTTTPSPPTTT-----PSPPTTTTTTPPPTTTPSPP 1503

Query: 1050 AGIPPPPPLPGAGIPPP----PPLPGAGIPPPP--PLPGAGIPPPPPLPGAGIPP---PP 1100
               P  PP     +PP     PP      PPP   P P    P  PP     +PP   P 
Sbjct: 1504 TTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPS 1563

Query: 1101 PLPGVGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPP-- 1155
            P P     PPP   P P     P PP      PPP   P       PP      PPP   
Sbjct: 1564 PPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPS------PPTTTTTTPPPTTT 1617

Query: 1156 PLPGAGIPPPPPLPGAGIPP---PPPLPGVGIPPPP---PLPGVGIPPPPPLPGAGIPPP 1209
            P P    P  PP     +PP   P P P     PPP   P P     P PP+     PPP
Sbjct: 1618 PSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPP 1677

Query: 1210 PPLPGMGIPPAPAPPLP----PPGTGIPPPPLLPVSGPP--LLPQVGSSTLPTPQVCGFL 1263
               P   I   P+PP      P  T  P  P+   + P     P    +T+ TP      
Sbjct: 1678 TTTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTP 1737

Query: 1264 PPP 1266
             PP
Sbjct: 1738 SPP 1740



 Score =  108 bits (270), Expect = 4e-23
 Identities = 107/395 (27%), Positives = 132/395 (33%), Gaps = 51/395 (12%)

Query: 768  PCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQP-----PPPPSLLWSAGQ 822
            P PP     P     + +    +P   +    +  PT + S P      PPP+   S   
Sbjct: 1399 PSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPI 1458

Query: 823  GQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPL-----PCTESSSSMPGLGMVP 877
                + PP +  +   T+     ++    +    +PPP      P T   +       +P
Sbjct: 1459 STTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLP 1518

Query: 878  P---PPPPLPGMTVPTLPSTAIPQPP------PLQGTEMLPP---PPPPLPGAGIPPP-- 923
            P   P PP    T P  P T  P PP      P   T  LPP   P PP      PPP  
Sbjct: 1519 PTTTPSPPTTTTTTP--PPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTT 1576

Query: 924  PPLPGAGILPLPPLPGAGIPPP-----PPLPGAAIPPP--PPLPGAGIPLPPPLPGAGIP 976
             P P     P PP      PPP     PP      PPP   P P    P+ PP     +P
Sbjct: 1577 TPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLP 1636

Query: 977  P---PPPLPGAGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGAGI--PPPPPLPGA 1028
            P   P P P     PPP   P P     P PP+     PPP   P + I   P PP    
Sbjct: 1637 PTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTM 1696

Query: 1029 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1088
              P P   P + I           P PPP     +  P P      P PP      +PP 
Sbjct: 1697 TTPSPTTTPSSPITTTTTPSSTTTPSPPP---TTMTTPSP---TTTPSPPTTTMTTLPPT 1750

Query: 1089 PPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPP 1123
                     P PP     I PP   P +   P  P
Sbjct: 1751 TTSSPLTTTPLPP----SITPPTFSPFSTTTPTTP 1781



 Score =  107 bits (267), Expect = 1e-22
 Identities = 129/552 (23%), Positives = 171/552 (30%), Gaps = 63/552 (11%)

Query: 768  PCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGS 827
            P P G ++   T   +  ++  +P     Q  +  P  + +   P P+     G   P +
Sbjct: 3774 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT---PTGTQTPTT 3830

Query: 828  QPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPG-LGMVPPPPPPLPGM 886
             P  + +T   T       +        P+  P+  T + +  P   G   P   P+   
Sbjct: 3831 TPITTTTTVTPTPTPTGTQT--------PTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3882

Query: 887  TV----PTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAG-ILPLPPLPGAG 941
            T     PT   T  P   P+  T  + P P P  G   P   P+     + P P   G  
Sbjct: 3883 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT-GTQTPTTTPITTTTTVTPTPTPTGTQ 3941

Query: 942  IPPPPPLPGAAIPPPPPLP-GAGIPLPPPLPGAGIPPPPPLP-GAGIPPPPPLPGAGIPP 999
             P   P+       P P P G   P   P+       P P P G   P   P+       
Sbjct: 3942 TPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVT 4001

Query: 1000 PPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPP 1056
            P P P G   P   P+       P P P G   P   P+       P P P G   P   
Sbjct: 4002 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 4061

Query: 1057 PLPGAGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPGVGIPPPPPLP 1114
            P+       P P P G   P   P+       P P P G   P   P+       P P P
Sbjct: 4062 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 4121

Query: 1115 -GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPRVGIPPPPPLP-GAGIPPPPPLPGA 1171
             G   P   P+       P P P G   P   P+       P P P G   P   P+   
Sbjct: 4122 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 4181

Query: 1172 GIPPPPPLP-GVGIPPPP-----PLPGVGIPPPPPLPG-------------------AGI 1206
                P P P G    PP      P+  +    PPP                      + +
Sbjct: 4182 TTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLSTL 4241

Query: 1207 PPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQ----VGSSTLPTPQ---- 1258
            PP   +     P  P  P    G     PP    + PP  P      GSS+ PTP     
Sbjct: 4242 PPAIEMTSTAPPSTPTAPTTTSGGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTVQT 4301

Query: 1259 --VCGFLPPPLP 1268
                 + P P P
Sbjct: 4302 TTTSAWTPTPTP 4313



 Score =  102 bits (254), Expect = 3e-21
 Identities = 125/542 (23%), Positives = 170/542 (31%), Gaps = 48/542 (8%)

Query: 768  PCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGS 827
            P P G ++   T   +  ++  +P     Q  +  P  + +   P P+     G   P +
Sbjct: 2164 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT---PTGTQTPTT 2220

Query: 828  QPPHSISTEFQT-----SHEHSVSSAFKNSCNIPSPPPL----PCTESSSSMPGLGMVPP 878
             P  + +T   T     +   + +     +   P+P P     P T   ++   +   P 
Sbjct: 2221 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2280

Query: 879  PPPPLPGMTVPTLPSTAI-----------PQPPPLQGTEMLPPPPPPLPGAGIPPPPPL- 926
            P       T P   +T +           P   P+  T  + P P P  G   P   P+ 
Sbjct: 2281 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP-TGTQTPTTTPIT 2339

Query: 927  PGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLP-GAGIPLPPPLPGAGIPPPPPLP-GA 984
                + P P   G   P   P+       P P P G   P   P+       P P P G 
Sbjct: 2340 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2399

Query: 985  GIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPGAGIP 1042
              P   P+       P P P G   P   P+       P P P G   P   P+      
Sbjct: 2400 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2459

Query: 1043 PPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPP 1099
             P P P G   P   P+       P P P G   P   P+       P P P G   P  
Sbjct: 2460 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2519

Query: 1100 PPLPGVGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPRVGIPPPPPL 1157
             P+       P P P G   P   P+       P P P G   P   P+       P P 
Sbjct: 2520 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2579

Query: 1158 P-GAGIPPPPPLPGAGIPPPPPLP-GVGIPPPPPLPGVGIPPPPPLP-GAGIPPPPPL-P 1213
            P G   P   P+       P P P G   P   P+       P P P G   P   P+  
Sbjct: 2580 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2639

Query: 1214 GMGIPPAPAP---------PLPPPGTGIPPPPLLPVSGPPLLPQVGSSTL-PTPQVCGFL 1263
               + P P P         P+    T  P P       P   P   ++T+ PTP   G  
Sbjct: 2640 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2699

Query: 1264 PP 1265
             P
Sbjct: 2700 TP 2701



 Score =  102 bits (254), Expect = 3e-21
 Identities = 125/542 (23%), Positives = 170/542 (31%), Gaps = 48/542 (8%)

Query: 768  PCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGS 827
            P P G ++   T   +  ++  +P     Q  +  P  + +   P P+     G   P +
Sbjct: 2555 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT---PTGTQTPTT 2611

Query: 828  QPPHSISTEFQT-----SHEHSVSSAFKNSCNIPSPPPL----PCTESSSSMPGLGMVPP 878
             P  + +T   T     +   + +     +   P+P P     P T   ++   +   P 
Sbjct: 2612 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2671

Query: 879  PPPPLPGMTVPTLPSTAI-----------PQPPPLQGTEMLPPPPPPLPGAGIPPPPPL- 926
            P       T P   +T +           P   P+  T  + P P P  G   P   P+ 
Sbjct: 2672 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP-TGTQTPTTTPIT 2730

Query: 927  PGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLP-GAGIPLPPPLPGAGIPPPPPLP-GA 984
                + P P   G   P   P+       P P P G   P   P+       P P P G 
Sbjct: 2731 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2790

Query: 985  GIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPGAGIP 1042
              P   P+       P P P G   P   P+       P P P G   P   P+      
Sbjct: 2791 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2850

Query: 1043 PPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPP 1099
             P P P G   P   P+       P P P G   P   P+       P P P G   P  
Sbjct: 2851 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 2910

Query: 1100 PPLPGVGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPRVGIPPPPPL 1157
             P+       P P P G   P   P+       P P P G   P   P+       P P 
Sbjct: 2911 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2970

Query: 1158 P-GAGIPPPPPLPGAGIPPPPPLP-GVGIPPPPPLPGVGIPPPPPLP-GAGIPPPPPL-P 1213
            P G   P   P+       P P P G   P   P+       P P P G   P   P+  
Sbjct: 2971 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3030

Query: 1214 GMGIPPAPAP---------PLPPPGTGIPPPPLLPVSGPPLLPQVGSSTL-PTPQVCGFL 1263
               + P P P         P+    T  P P       P   P   ++T+ PTP   G  
Sbjct: 3031 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3090

Query: 1264 PP 1265
             P
Sbjct: 3091 TP 3092



 Score =  102 bits (254), Expect = 3e-21
 Identities = 125/542 (23%), Positives = 170/542 (31%), Gaps = 48/542 (8%)

Query: 768  PCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGS 827
            P P G ++   T   +  ++  +P     Q  +  P  + +   P P+     G   P +
Sbjct: 2946 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT---PTGTQTPTT 3002

Query: 828  QPPHSISTEFQT-----SHEHSVSSAFKNSCNIPSPPPL----PCTESSSSMPGLGMVPP 878
             P  + +T   T     +   + +     +   P+P P     P T   ++   +   P 
Sbjct: 3003 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3062

Query: 879  PPPPLPGMTVPTLPSTAI-----------PQPPPLQGTEMLPPPPPPLPGAGIPPPPPL- 926
            P       T P   +T +           P   P+  T  + P P P  G   P   P+ 
Sbjct: 3063 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP-TGTQTPTTTPIT 3121

Query: 927  PGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLP-GAGIPLPPPLPGAGIPPPPPLP-GA 984
                + P P   G   P   P+       P P P G   P   P+       P P P G 
Sbjct: 3122 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3181

Query: 985  GIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPGAGIP 1042
              P   P+       P P P G   P   P+       P P P G   P   P+      
Sbjct: 3182 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 3241

Query: 1043 PPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPP 1099
             P P P G   P   P+       P P P G   P   P+       P P P G   P  
Sbjct: 3242 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3301

Query: 1100 PPLPGVGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPRVGIPPPPPL 1157
             P+       P P P G   P   P+       P P P G   P   P+       P P 
Sbjct: 3302 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3361

Query: 1158 P-GAGIPPPPPLPGAGIPPPPPLP-GVGIPPPPPLPGVGIPPPPPLP-GAGIPPPPPL-P 1213
            P G   P   P+       P P P G   P   P+       P P P G   P   P+  
Sbjct: 3362 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3421

Query: 1214 GMGIPPAPAP---------PLPPPGTGIPPPPLLPVSGPPLLPQVGSSTL-PTPQVCGFL 1263
               + P P P         P+    T  P P       P   P   ++T+ PTP   G  
Sbjct: 3422 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3481

Query: 1264 PP 1265
             P
Sbjct: 3482 TP 3483



 Score =  102 bits (254), Expect = 3e-21
 Identities = 125/542 (23%), Positives = 170/542 (31%), Gaps = 48/542 (8%)

Query: 768  PCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGS 827
            P P G ++   T   +  ++  +P     Q  +  P  + +   P P+     G   P +
Sbjct: 3337 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT---PTGTQTPTT 3393

Query: 828  QPPHSISTEFQT-----SHEHSVSSAFKNSCNIPSPPPL----PCTESSSSMPGLGMVPP 878
             P  + +T   T     +   + +     +   P+P P     P T   ++   +   P 
Sbjct: 3394 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3453

Query: 879  PPPPLPGMTVPTLPSTAI-----------PQPPPLQGTEMLPPPPPPLPGAGIPPPPPL- 926
            P       T P   +T +           P   P+  T  + P P P  G   P   P+ 
Sbjct: 3454 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP-TGTQTPTTTPIT 3512

Query: 927  PGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLP-GAGIPLPPPLPGAGIPPPPPLP-GA 984
                + P P   G   P   P+       P P P G   P   P+       P P P G 
Sbjct: 3513 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3572

Query: 985  GIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPGAGIP 1042
              P   P+       P P P G   P   P+       P P P G   P   P+      
Sbjct: 3573 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 3632

Query: 1043 PPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPP 1099
             P P P G   P   P+       P P P G   P   P+       P P P G   P  
Sbjct: 3633 TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTT 3692

Query: 1100 PPLPGVGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPRVGIPPPPPL 1157
             P+       P P P G   P   P+       P P P G   P   P+       P P 
Sbjct: 3693 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 3752

Query: 1158 P-GAGIPPPPPLPGAGIPPPPPLP-GVGIPPPPPLPGVGIPPPPPLP-GAGIPPPPPL-P 1213
            P G   P   P+       P P P G   P   P+       P P P G   P   P+  
Sbjct: 3753 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3812

Query: 1214 GMGIPPAPAP---------PLPPPGTGIPPPPLLPVSGPPLLPQVGSSTL-PTPQVCGFL 1263
               + P P P         P+    T  P P       P   P   ++T+ PTP   G  
Sbjct: 3813 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3872

Query: 1264 PP 1265
             P
Sbjct: 3873 TP 3874



 Score =  101 bits (252), Expect = 5e-21
 Identities = 109/419 (26%), Positives = 131/419 (31%), Gaps = 31/419 (7%)

Query: 877  PPPPPPLPGMTV------PTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPL-PGA 929
            P PP   P  T       PT   T  P   P+  T  + P P P  G   P   P+    
Sbjct: 1893 PTPPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP-TGTQTPTTTPITTTT 1951

Query: 930  GILPLPPLPGAGIPPPPPLPGAAIPPPPPLP-GAGIPLPPPLPGAGIPPPPPLP-GAGIP 987
             + P P   G   P   P+       P P P G   P   P+       P P P G   P
Sbjct: 1952 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 2011

Query: 988  PPPPLPGAGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPGAGIPPPP 1045
               P+       P P P G   P   P+       P P P G   P   P+       P 
Sbjct: 2012 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2071

Query: 1046 PLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPL 1102
            P P G   P   P+       P P P G   P   P+       P P P G   P   P+
Sbjct: 2072 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2131

Query: 1103 PGVGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLP-GAGIPPPPPLPRVGIPPPPPLP-G 1159
                   P P P G   P   P+       P P P G   P   P+       P P P G
Sbjct: 2132 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2191

Query: 1160 AGIPPPPPLPGAGIPPPPPLP-GVGIPPPPPLPGVGIPPPPPLP-GAGIPPPPPL-PGMG 1216
               P   P+       P P P G   P   P+       P P P G   P   P+     
Sbjct: 2192 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2251

Query: 1217 IPPAPAP---------PLPPPGTGIPPPPLLPVSGPPLLPQVGSSTL-PTPQVCGFLPP 1265
            + P P P         P+    T  P P       P   P   ++T+ PTP   G   P
Sbjct: 2252 VTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 2310



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 75/311 (24%), Positives = 97/311 (31%), Gaps = 21/311 (6%)

Query: 746  TSPTEEGGVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQ 805
            T+P+      T PP    P  P   P       T      +        +    +  P+ 
Sbjct: 1482 TTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSP 1541

Query: 806  SISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTE 865
              + P  PP+   +       S PP + +T   T+     ++   +   I +  P P T 
Sbjct: 1542 PTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTT 1601

Query: 866  SSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPP 925
             S         PP   P P  T P  P T+    PP       P PPP       P   P
Sbjct: 1602 PSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPP----TTTPSPPPTTTTTPPPTTTP 1657

Query: 926  LPGAGILPLPPLPGAGIPPPPPLPGAAI--PPPPPLPGAGIPLPPPLPGAGIPPPPPLPG 983
             P     P PP+     PPP   P + I   P PP      P P   P + I        
Sbjct: 1658 SPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSS 1717

Query: 984  AGIPPPPP----LPGAGIPPPPPLPGAGIPPP----PPLPGAGIPPPPPLPGAGIPPPPP 1035
               P PPP     P     P PP       PP     PL    +PP        I PP  
Sbjct: 1718 TTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPP-------SITPPTF 1770

Query: 1036 LPGAGIPPPPP 1046
             P +   P  P
Sbjct: 1771 SPFSTTTPTTP 1781



 Score = 40.0 bits (92), Expect = 0.020
 Identities = 45/191 (23%), Positives = 66/191 (34%), Gaps = 18/191 (9%)

Query: 768  PCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGS 827
            P P G ++   T   +  ++  +P     Q  +  P  + +   P P+   +  Q  P +
Sbjct: 4142 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP--TGTQTGPPT 4199

Query: 828  QPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMT 887
                +   E  TS+    SS  + S +  SP     T  S+  P + M    PP  P  T
Sbjct: 4200 HTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLSTLPPAIEMTSTAPPSTP--T 4257

Query: 888  VPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLP-----PLPGAGI 942
             PT  S          G  + PPP       G P      G+   P P         A  
Sbjct: 4258 APTTTS---------GGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTVQTTTTSAWT 4308

Query: 943  PPPPPLPGAAI 953
            P P PL   +I
Sbjct: 4309 PTPTPLSTPSI 4319


>gi|150417989 cyclin K isoform 1 [Homo sapiens]
          Length = 580

 Score =  148 bits (373), Expect = 5e-35
 Identities = 110/298 (36%), Positives = 126/298 (42%), Gaps = 31/298 (10%)

Query: 866  SSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPP-PLQGTEMLPPPPPPLPGAGIPPPP 924
            S SS P       P  P         P    PQP  P Q    +   P     A  PPPP
Sbjct: 294  SQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPP 353

Query: 925  PLPGAGILPLPPLPGAGIPPP--PPLPGAA--IPPPPPLPGAGIP---LPPPLPGAGIPP 977
             +P       PPLP A  PP   PPL  A     PP P+    +P   +PPP   A +  
Sbjct: 354  KIPKIETTH-PPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQ 412

Query: 978  PPPLPGAGIPPPPPLPGAGIPPPPP-LPGAGIPPPPPL-----PGAGIPPPPPLPGAGIP 1031
            PPPLP    PPPP     G+      + G G      +     P  G  PP   P A +P
Sbjct: 413  PPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLP 472

Query: 1032 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP- 1090
              P +     PPPPP+P    PPP   P   IPPP P    G PPPPP      PPPPP 
Sbjct: 473  YHPHVYPPN-PPPPPVP----PPPASFPPPAIPPPTP----GYPPPPPTYNPNFPPPPPR 523

Query: 1091 LPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPR 1148
            LP     PP P PG+G+PP      A  PPP   PG   P PPP+P  G+PP   L R
Sbjct: 524  LPPTHAVPPHPPPGLGLPP------ASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGR 575



 Score =  147 bits (371), Expect = 9e-35
 Identities = 114/317 (35%), Positives = 132/317 (41%), Gaps = 35/317 (11%)

Query: 896  IPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPP-PLPGAAIP 954
            + QPP LQ T  +P      P     P  P       P      A  P  P P P +   
Sbjct: 273  LQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSS--- 329

Query: 955  PPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP--PPLPGA--GIPP 1010
             P  +  A +  P     A  PPPP +P      PP LP A  PP   PPL  A     P
Sbjct: 330  -PRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPP-LPPAHPPPDRKPPLAAALGEAEP 387

Query: 1011 PPPLPGAGIPP---PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP-LPGAGIPPP 1066
            P P+    +P    PPP   A +  PPPLP    PPPP     G+      + G G    
Sbjct: 388  PGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSL 447

Query: 1067 PPL-----PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPP 1121
              +     P  G  PP   P A +P  P +     PPPPP+P    PPP   P   IPPP
Sbjct: 448  QSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPN-PPPPPVP----PPPASFPPPAIPPP 502

Query: 1122 PPLPGAGIPPPPPLPGAGIPPPPP-LPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1180
             P    G PPPPP      PPPPP LP     PP P PG G+PP      A  PPP   P
Sbjct: 503  TP----GYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPP------ASYPPPAVPP 552

Query: 1181 GVGIPPPPPLPGVGIPP 1197
            G   P PPP+P  G+PP
Sbjct: 553  GGQPPVPPPIPPPGMPP 569



 Score =  138 bits (347), Expect = 5e-32
 Identities = 110/314 (35%), Positives = 131/314 (41%), Gaps = 35/314 (11%)

Query: 952  AIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1011
            ++ P P +P      P     +  P  P       P     P      P P P +    P
Sbjct: 278  SLQPTPQVPQVQQSQPSQ---SSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSS----P 330

Query: 1012 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP--PPLPGA--GIPPPP 1067
              +  A +  P     A  PPPP +P      PP LP A  PP   PPL  A     PP 
Sbjct: 331  RQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPP-LPPAHPPPDRKPPLAAALGEAEPPG 389

Query: 1068 PLPGAGIPP---PPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPP-LPGAGIPPPPP 1123
            P+    +P    PPP   A +  PPPLP    PPPP     G+      + G G      
Sbjct: 390  PVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQS 449

Query: 1124 L-----PGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1178
            +     P  G  PP   P A +P  P +     PPPPP+P    PPP   P   IPPP P
Sbjct: 450  MMKTEGPSYGALPPAYGPPAHLPYHPHVYPPN-PPPPPVP----PPPASFPPPAIPPPTP 504

Query: 1179 LPGVGIPPPPPLPGVGIPPPPP-LPGAGIPPPPPLPGMGIPPAP-APPLPPPGTGIPPPP 1236
                G PPPPP      PPPPP LP     PP P PG+G+PPA   PP  PPG   P PP
Sbjct: 505  ----GYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPP 560

Query: 1237 LLPVSGPPLLPQVG 1250
             +P   PP +P VG
Sbjct: 561  PIP---PPGMPPVG 571



 Score =  129 bits (323), Expect = 3e-29
 Identities = 105/306 (34%), Positives = 126/306 (41%), Gaps = 71/306 (23%)

Query: 797  QLDSHQPTQSISQPPPPPSL--LWSAGQGQPGSQPPHSI---STEFQTSHEHSVSSAFKN 851
            Q+   QP+QS S+P  P        A Q QP  QP       S+  Q      VS   +N
Sbjct: 287  QVQQSQPSQS-SEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEEN 345

Query: 852  SCNIPSPPPLPCTESSSSMPGLGMVPPPPP--PLPGMTVPTLPSTAIPQPP-PLQGTEM- 907
                P PP +P  E++         PP PP  P P    P   +    +PP P+  T++ 
Sbjct: 346  KAAEPPPPKIPKIETTH--------PPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLP 397

Query: 908  ---LPPP--------PPPLPGAGIPPPPP------------LPGAGILPLPPL-----PG 939
               +PPP        PPPLP    PPPP             + G G   L  +     P 
Sbjct: 398  KVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPS 457

Query: 940  AGIPPPPPLPGAAIP----------PPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPP 989
             G  PP   P A +P          PPPP+P      PPP     IPPP P    G PPP
Sbjct: 458  YGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPP----AIPPPTP----GYPPP 509

Query: 990  PPLPGAGIPPPPP-LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1048
            PP      PPPPP LP     PP P PG G+PP      A  PPP   PG   P PPP+P
Sbjct: 510  PPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPP------ASYPPPAVPPGGQPPVPPPIP 563

Query: 1049 GAGIPP 1054
              G+PP
Sbjct: 564  PPGMPP 569



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 90/295 (30%), Positives = 113/295 (38%), Gaps = 75/295 (25%)

Query: 742  KSIQTSPTEEGGVLTLPPVDGLPG----RPPCPPGAESGPQTK--FCSEISLIVSPRRIS 795
            +++  SP EE      PP   +P      PP PP A   P  K    + +     P  + 
Sbjct: 335  RAVVVSPKEENKAAE-PPPPKIPKIETTHPPLPP-AHPPPDRKPPLAAALGEAEPPGPVD 392

Query: 796  ------VQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAF 849
                  VQ+        + QPPP P         +P   PP S  T   T+  +     +
Sbjct: 393  ATDLPKVQIPPPAHPAPVHQPPPLPH--------RPPPPPPSSYMTGMSTTSSYMSGEGY 444

Query: 850  KNSCNIPSPPPLPCTESSSSMPGLGMVPP---PPPPLPGMTVPTLPSTAIPQPPPLQGTE 906
            ++  ++        TE     P  G +PP   PP  LP       P    P PPP     
Sbjct: 445  QSLQSMMK------TEG----PSYGALPPAYGPPAHLPYH-----PHVYPPNPPP----P 485

Query: 907  MLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPL 966
             +PPPP   P   IPPP P               G PPPPP      PPPPP       L
Sbjct: 486  PVPPPPASFPPPAIPPPTP---------------GYPPPPPTYNPNFPPPPP------RL 524

Query: 967  PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1021
            PP      +PP PP PG G+PP      A  PPP   PG   P PPP+P  G+PP
Sbjct: 525  PPT---HAVPPHPP-PGLGLPP------ASYPPPAVPPGGQPPVPPPIPPPGMPP 569



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 56/173 (32%), Positives = 76/173 (43%), Gaps = 27/173 (15%)

Query: 801 HQPTQSISQPPPPPSLLWSAGQGQPGS----QPPHSISTEFQTSHEH--SVSSAFKNSCN 854
           HQP     +PPPPP   +  G     S    +   S+ +  +T      ++  A+    +
Sbjct: 411 HQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAH 470

Query: 855 IP--------SPPPLPCTESSSSMPGLGMVPPPP--PPLPGMTVPTLPSTAIPQPPPLQG 904
           +P        +PPP P     +S P   + PP P  PP P    P  P    P PP L  
Sbjct: 471 LPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFP----PPPPRLPP 526

Query: 905 TEMLPPPPPPLPGAGIPP----PPPLPGAGILPLPP-LPGAGIPPPPPLPGAA 952
           T  +PP PPP  G G+PP    PP +P  G  P+PP +P  G+PP   L  AA
Sbjct: 527 THAVPPHPPP--GLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAA 577



 Score = 36.6 bits (83), Expect = 0.22
 Identities = 41/151 (27%), Positives = 58/151 (38%), Gaps = 14/151 (9%)

Query: 191 EQEDLLSDIQQAIRLQQQQQQQLQLQLQQQQQQ-QQLQGAEEPAAPPTAVSPQPGAFLGL 249
           +Q   L    Q  ++QQ Q  Q     Q QQ+  QQ    ++PA  P   SPQP +   +
Sbjct: 274 QQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQV 333

Query: 250 DRFLLGPSGGAGEA--PGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAP-- 305
            R ++       +A  P  P   +  +    LP    A P   ++PP    L  +E P  
Sbjct: 334 KRAVVVSPKEENKAAEPPPPKIPKIETTHPPLP---PAHPPPDRKPPLAAALGEAEPPGP 390

Query: 306 ----SLPAAQ--PAAKDSPSSTAFPFPEAGP 330
                LP  Q  P A  +P     P P   P
Sbjct: 391 VDATDLPKVQIPPPAHPAPVHQPPPLPHRPP 421


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.135    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 115,914,996
Number of Sequences: 37866
Number of extensions: 11779377
Number of successful extensions: 368625
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1192
Number of HSP's successfully gapped in prelim test: 2221
Number of HSP's that attempted gapping in prelim test: 70159
Number of HSP's gapped (non-prelim): 90952
length of query: 1722
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1606
effective length of database: 13,855,062
effective search space: 22251229572
effective search space used: 22251229572
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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