Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 158937236
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|158937236 aminopeptidase puromycin sensitive [Homo sapiens]
(919 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|158937236 aminopeptidase puromycin sensitive [Homo sapiens] 1858 0.0
gi|132814467 glutamyl aminopeptidase [Homo sapiens] 482 e-136
gi|194306629 endoplasmic reticulum aminopeptidase 2 [Homo sapiens] 450 e-126
gi|11641261 endoplasmic reticulum aminopeptidase 2 [Homo sapiens] 450 e-126
gi|157266300 membrane alanine aminopeptidase precursor [Homo sap... 444 e-124
gi|94818891 type 1 tumor necrosis factor receptor shedding amino... 432 e-121
gi|94818901 type 1 tumor necrosis factor receptor shedding amino... 432 e-121
gi|61742777 leucyl/cystinyl aminopeptidase isoform 1 [Homo sapiens] 413 e-115
gi|61742775 leucyl/cystinyl aminopeptidase isoform 2 [Homo sapiens] 413 e-115
gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo ... 390 e-108
gi|194239713 laeverin [Homo sapiens] 300 3e-81
gi|4505029 leukotriene A4 hydrolase [Homo sapiens] 115 2e-25
gi|40316915 arginyl aminopeptidase [Homo sapiens] 82 2e-15
gi|54020718 arginyl aminopeptidase (aminopeptidase B)-like 1 [Ho... 59 3e-08
gi|4507347 TBP-associated factor 2 [Homo sapiens] 48 5e-05
gi|154813197 talpid3 protein [Homo sapiens] 35 0.32
gi|213513324 hypothetical protein LOC401115 [Homo sapiens] 32 2.1
gi|183396780 ubiquitin specific protease 20 [Homo sapiens] 32 3.6
gi|183397136 ubiquitin specific protease 20 [Homo sapiens] 32 3.6
gi|183397134 ubiquitin specific protease 20 [Homo sapiens] 32 3.6
gi|54607018 RYK receptor-like tyrosine kinase isoform 2 [Homo sa... 32 3.6
gi|54607020 RYK receptor-like tyrosine kinase isoform 1 [Homo sa... 32 3.6
gi|157426891 endothelin converting enzyme-like 1 [Homo sapiens] 31 6.1
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens] 30 7.9
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens] 30 7.9
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens] 30 7.9
>gi|158937236 aminopeptidase puromycin sensitive [Homo sapiens]
Length = 919
Score = 1858 bits (4814), Expect = 0.0
Identities = 919/919 (100%), Positives = 919/919 (100%)
Query: 1 MWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSP 60
MWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSP
Sbjct: 1 MWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSP 60
Query: 61 INYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGF 120
INYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGF
Sbjct: 61 INYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGF 120
Query: 121 NYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTPSGEVRYAAVTQFE 180
NYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTPSGEVRYAAVTQFE
Sbjct: 121 NYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTPSGEVRYAAVTQFE 180
Query: 181 ATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPV 240
ATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPV
Sbjct: 181 ATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPV 240
Query: 241 MSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPY 300
MSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPY
Sbjct: 241 MSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPY 300
Query: 301 PLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFG 360
PLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFG
Sbjct: 301 PLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFG 360
Query: 361 NLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIE 420
NLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIE
Sbjct: 361 NLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIE 420
Query: 421 VSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWE 480
VSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWE
Sbjct: 421 VSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWE 480
Query: 481 SLENASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQW 540
SLENASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQW
Sbjct: 481 SLENASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQW 540
Query: 541 MVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLES 600
MVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLES
Sbjct: 541 MVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLES 600
Query: 601 LLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLG 660
LLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLG
Sbjct: 601 LLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLG 660
Query: 661 ILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKA 720
ILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKA
Sbjct: 661 ILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKA 720
Query: 721 TLEEARRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIE 780
TLEEARRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIE
Sbjct: 721 TLEEARRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIE 780
Query: 781 RVLGATLLPDLIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYN 840
RVLGATLLPDLIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYN
Sbjct: 781 RVLGATLLPDLIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYN 840
Query: 841 RYQGGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKR 900
RYQGGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKR
Sbjct: 841 RYQGGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKR 900
Query: 901 DAESIHQYLLQRKASPPTV 919
DAESIHQYLLQRKASPPTV
Sbjct: 901 DAESIHQYLLQRKASPPTV 919
>gi|132814467 glutamyl aminopeptidase [Homo sapiens]
Length = 957
Score = 482 bits (1241), Expect = e-136
Identities = 299/874 (34%), Positives = 469/874 (53%), Gaps = 34/874 (3%)
Query: 53 RLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDI--ITASYAPE 110
RLP V+P++Y L +KP L + T+ G + + + T + ++ + I + P
Sbjct: 92 RLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPS 151
Query: 111 GDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGT----LKIDFVGELNDKMKGFYRSKYTT 166
GD+ F Y+ + E V + L +G L ++F G LN + GFYR+ YT
Sbjct: 152 GDQVQVRRCFEYKKQ-EYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTE 210
Query: 167 PSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPD 226
+G+V+ T E TDAR++FPC+DEP KAT+ IS+ PK+ ALSNM V +
Sbjct: 211 -NGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESV-- 267
Query: 227 DENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAA 286
D+ F ++ MSTYLV F V ++D V+ S G + +Y + ++A +
Sbjct: 268 DDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITK 327
Query: 287 KTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWV 346
++++YF + Y LPK+D IAI DF GAMENWGL+TYRET LL DPK S SS++Q V
Sbjct: 328 SVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRV 387
Query: 347 ALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTR 406
A VV HEL HQWFGN+VTM+WW LWLNEGFAS+ E+L V+H ++ + Q + D
Sbjct: 388 ATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLP 447
Query: 407 AQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLT 466
QE D+L +SHPI V+V P E+ +FD ISYSKG+S++RML D+I ++F+KG MYL
Sbjct: 448 VQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLE 507
Query: 467 KFQQKNAATEDLWESLENASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKF 526
K+Q KNA T D W +LE AS P+ VM+TWT+QMG+P++ V + ++QK+F
Sbjct: 508 KYQFKNAKTSDFWAALEEASRLPVKEVMDTWTRQMGYPVLNVNG-------VKNITQKRF 560
Query: 527 C----AGGSYVGEDCP-QWMVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKL 581
A S D W +P+ T ++ + L +K + + N + ++K+
Sbjct: 561 LLDPRANPSQPPSDLGYTWNIPVK-WTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKI 619
Query: 582 NLGTVGFYRTQYSSAMLESLLP--GIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKV 639
N +GFYR Y A +S+ + + DR L +D F+LARA ++ L +
Sbjct: 620 NPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNL 679
Query: 640 MEAFVNEPNYTVWSD-LSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGE 698
+ E N+ W +S I+S + Y I+E+ + PI + LGW+
Sbjct: 680 TKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWN--DAG 737
Query: 699 GHLDALLRGLVLGKLGKAGHKATLEEARRRFKDHVEGKQILSADLRSPVYLTVLKH-GDG 757
H+ LLR VLG K G + L A F+ + G L +LR VY +++ G+
Sbjct: 738 DHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNE 797
Query: 758 TTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFALSEE-VRPQDTVSVIGGV 816
+ + L+ +++ + +EK ++ L + L+ + L ++ QD +VI +
Sbjct: 798 ISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYI 857
Query: 817 AGGSKHGRKAAWKFIKDNWEELYNRYQ-GGFLISRLIKLSVEGFAVDKMAGEVKAFFESH 875
+ S +G+ AW +I+ NW+ L NRY + R++ ++ E F + ++++FF +
Sbjct: 858 SYNS-YGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIA-EPFNTELQLWQMESFFAKY 915
Query: 876 P-APSAERTIQQCCENILLNAAWLKRDAESIHQY 908
P A + E+ +Q E + N WLK+ +I ++
Sbjct: 916 PQAGAGEKPREQVLETVKNNIEWLKQHRNTIREW 949
>gi|194306629 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]
Length = 960
Score = 450 bits (1158), Expect = e-126
Identities = 305/929 (32%), Positives = 470/929 (50%), Gaps = 86/929 (9%)
Query: 42 LAAMPEKRPFE--RLPADVSPINYSLCLKPDL--LDFTFEGKLEAAAQVRQATNQIVMNC 97
+A E+ P++ RLP+ V P++Y L + P+L LDF K+E V AT I+++
Sbjct: 55 VATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVL--VSNATQFIILHS 112
Query: 98 ADIDIITASYAPEGDEEIHATGFNYQ----NEDEKVTLSFPSTLQTGTGTLK----IDFV 149
D++I A+ E D G + E++ L P L T LK +DF
Sbjct: 113 KDLEITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKL---TPHLKYYVAMDFQ 169
Query: 150 GELNDKMKGFYRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKD 209
+L D +GFY+S Y T GE R AVT FE T AR AFPC+DEP KA F I +
Sbjct: 170 AKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESR 229
Query: 210 RVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVY 269
+ALSNM + K + L+E F T MSTYLVA++V ++ + + GV V +Y
Sbjct: 230 HIALSNMPKV--KTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIY 287
Query: 270 TPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRET 329
K Q +AL+ + K L FY+ YF++ YPL K+DLIAI DFA GAMENWGL+TYRET
Sbjct: 288 ASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRET 347
Query: 330 ALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHC 389
+LL DPK S +S + WV V+ HELAHQWFGNLVTMEWW +WL EGFA ++E + V+
Sbjct: 348 SLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNAT 407
Query: 390 FPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLH 449
+PE F++ + + D+L++S PI P+++ E+FD +SY+KGA ++ ML
Sbjct: 408 YPELQFDDYFLNVCFEVITK-DSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLK 466
Query: 450 DYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENA------------------------ 485
D++G++ F+KG+ YL KF +NA +DLW SL N+
Sbjct: 467 DFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLA 526
Query: 486 ---SGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWM- 541
+ +M TWT Q G PL+ V+ +D LRL Q++F G V ++ P+W
Sbjct: 527 FLGENAEVKEMMTTWTLQKGIPLLVVK----QDGCSLRLQQERFLQG---VFQEDPEWRA 579
Query: 542 --------VPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQY 593
+P+T STS N IL K + L + WVK N+ + G+Y Y
Sbjct: 580 LQERYLWHIPLTYSTSSS-NVIHRHILKSKTD---TLDLPEKTSWVKFNVDSNGYYIVHY 635
Query: 594 SSAMLESLLPGIRD--LSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTV 651
+ L+ + L P DR+GL +D+F L AG ++ + L + +E +
Sbjct: 636 EGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPA 695
Query: 652 WSDLSCNLGILSTLLSH---TDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGL 708
+ L ++ +D E ++ ++ F P+ +R W K D +LR
Sbjct: 696 LLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSV--WDRMLRSA 753
Query: 709 VLGKLGKAGHKATLEEARRRFKDHVE--GKQILSADLRSPVYLTVLKHGDGTTL--DIML 764
+L H +++A F +E GK + D+ VY G TT + +L
Sbjct: 754 LLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVYSV----GAQTTAGWNYLL 809
Query: 765 KLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFALSEEV-RPQDTVSVIGGVAGGSKHG 823
+ ++ + E+N+I L + + + K++ + +V + Q+ +++ +A K G
Sbjct: 810 EQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPK-G 868
Query: 824 RKAAWKFIKDNWEELYNRYQ-GGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAER 882
++ AW F+++NW L ++ G + I +I + F+ EVK FFES A +
Sbjct: 869 QQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHL 928
Query: 883 TI-QQCCENILLNAAWLKRDAESIHQYLL 910
I Q E I N WL+++ ++ +L+
Sbjct: 929 DIFQTVLETITKNIKWLEKNLPTLRTWLM 957
>gi|11641261 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]
Length = 960
Score = 450 bits (1158), Expect = e-126
Identities = 305/929 (32%), Positives = 470/929 (50%), Gaps = 86/929 (9%)
Query: 42 LAAMPEKRPFE--RLPADVSPINYSLCLKPDL--LDFTFEGKLEAAAQVRQATNQIVMNC 97
+A E+ P++ RLP+ V P++Y L + P+L LDF K+E V AT I+++
Sbjct: 55 VATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVL--VSNATQFIILHS 112
Query: 98 ADIDIITASYAPEGDEEIHATGFNYQ----NEDEKVTLSFPSTLQTGTGTLK----IDFV 149
D++I A+ E D G + E++ L P L T LK +DF
Sbjct: 113 KDLEITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKL---TPHLKYYVAMDFQ 169
Query: 150 GELNDKMKGFYRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKD 209
+L D +GFY+S Y T GE R AVT FE T AR AFPC+DEP KA F I +
Sbjct: 170 AKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESR 229
Query: 210 RVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVY 269
+ALSNM + K + L+E F T MSTYLVA++V ++ + + GV V +Y
Sbjct: 230 HIALSNMPKV--KTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIY 287
Query: 270 TPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRET 329
K Q +AL+ + K L FY+ YF++ YPL K+DLIAI DFA GAMENWGL+TYRET
Sbjct: 288 ASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRET 347
Query: 330 ALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHC 389
+LL DPK S +S + WV V+ HELAHQWFGNLVTMEWW +WL EGFA ++E + V+
Sbjct: 348 SLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNAT 407
Query: 390 FPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLH 449
+PE F++ + + D+L++S PI P+++ E+FD +SY+KGA ++ ML
Sbjct: 408 YPELQFDDYFLNVCFEVITK-DSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLK 466
Query: 450 DYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENA------------------------ 485
D++G++ F+KG+ YL KF +NA +DLW SL N+
Sbjct: 467 DFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLA 526
Query: 486 ---SGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWM- 541
+ +M TWT Q G PL+ V+ +D LRL Q++F G V ++ P+W
Sbjct: 527 FLGENAEVKEMMTTWTLQKGIPLLVVK----QDGCSLRLQQERFLQG---VFQEDPEWRA 579
Query: 542 --------VPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQY 593
+P+T STS N IL K + L + WVK N+ + G+Y Y
Sbjct: 580 LQERYLWHIPLTYSTSSS-NVIHRHILKSKTD---TLDLPEKTSWVKFNVDSNGYYIVHY 635
Query: 594 SSAMLESLLPGIRD--LSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTV 651
+ L+ + L P DR+GL +D+F L AG ++ + L + +E +
Sbjct: 636 EGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPA 695
Query: 652 WSDLSCNLGILSTLLSH---TDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGL 708
+ L ++ +D E ++ ++ F P+ +R W K D +LR
Sbjct: 696 LLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSV--WDRMLRSA 753
Query: 709 VLGKLGKAGHKATLEEARRRFKDHVE--GKQILSADLRSPVYLTVLKHGDGTTL--DIML 764
+L H +++A F +E GK + D+ VY G TT + +L
Sbjct: 754 LLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVYSV----GAQTTAGWNYLL 809
Query: 765 KLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFALSEEV-RPQDTVSVIGGVAGGSKHG 823
+ ++ + E+N+I L + + + K++ + +V + Q+ +++ +A K G
Sbjct: 810 EQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPK-G 868
Query: 824 RKAAWKFIKDNWEELYNRYQ-GGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAER 882
++ AW F+++NW L ++ G + I +I + F+ EVK FFES A +
Sbjct: 869 QQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHL 928
Query: 883 TI-QQCCENILLNAAWLKRDAESIHQYLL 910
I Q E I N WL+++ ++ +L+
Sbjct: 929 DIFQTVLETITKNIKWLEKNLPTLRTWLM 957
>gi|157266300 membrane alanine aminopeptidase precursor [Homo
sapiens]
Length = 967
Score = 444 bits (1142), Expect = e-124
Identities = 296/907 (32%), Positives = 456/907 (50%), Gaps = 65/907 (7%)
Query: 53 RLPADVSPINYSLCLKPDLLD-----FTFEGKLEAAAQVRQATNQIVMNCADIDIITASY 107
RLP + P +Y + L+P L + F+G ++AT+ I+++ ++ +
Sbjct: 75 RLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLS-- 132
Query: 108 APEGDEEI-HATGFNYQNEDEKVTLSFP----------STLQTGTGTLKIDFVGELNDKM 156
+G + G + + +K L P S ++ + +F GEL D +
Sbjct: 133 --QGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDL 190
Query: 157 KGFYRSKYTTPSGEVR-YAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSN 215
GFYRS+Y G VR A TQ +A DAR++FPC+DEPA+KA F+I+L+ PKD ALSN
Sbjct: 191 AGFYRSEYM--EGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSN 248
Query: 216 MNVIDRK-PYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGK 274
M P P+D N +F TP MSTYL+AF+V E+D+VE ++ +GV +R++
Sbjct: 249 MLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSA 308
Query: 275 --AEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALL 332
A G +AL V L F+ +++ PYPLPK D I + DF AGAMENWGLVTYRE +LL
Sbjct: 309 IAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLL 368
Query: 333 IDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPE 392
DP +S SS+++ V V+ HELAHQWFGNLVT+EWW LWLNEGFAS++EYL D+ P
Sbjct: 369 FDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPT 428
Query: 393 YDIWTQFVSADYTRAQELDALDNSHPIEV---SVGHPSEVDEIFDAISYSKGASVIRMLH 449
+++ V D R +DAL +SHP+ + P+++ E+FDAISYSKGASV+RML
Sbjct: 429 WNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLS 488
Query: 450 DYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENASGK-------PIAAVMNTWTKQMG 502
++ + FK+G+ YL F +N +LW+ L+ A + +MN WT QMG
Sbjct: 489 SFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMG 548
Query: 503 FPLIYVEAEQVEDDRLLRLSQKKFC----AGGSYVGEDCPQWMVPITISTSEDPNQAKLK 558
FP+I V D LSQ+ F + + E W+VPIT + D Q +
Sbjct: 549 FPVITV------DTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPIT--SIRDGRQQQDY 600
Query: 559 ILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGI-RDLS-LPPVDRL 616
L+D N L + ++WV LNL G+YR Y + + RD S +P ++R
Sbjct: 601 WLIDVRAQN-DLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRA 659
Query: 617 GLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQ 676
+ ND F+LA A + L + E Y W +L + ++ Y ++
Sbjct: 660 QIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMK 719
Query: 677 EFVKDVFSPI-----GERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKD 731
++K +P+ W P E +D + G E FK
Sbjct: 720 NYLKKQVTPLFIHFRNNTNNWREIP-ENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQ 778
Query: 732 HVE--GKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLP 789
+E + +LRS VY + G D + + A + E +++ L +
Sbjct: 779 WMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKEL 838
Query: 790 DLIQKVLTFALSEE-VRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGG-FL 847
++ + L++ L+ + +R QD S I + + G+ W F++ NW++L+N Y GG F
Sbjct: 839 WILNRYLSYTLNPDLIRKQDATSTIISIT-NNVIGQGLVWDFVQSNWKKLFNDYGGGSFS 897
Query: 848 ISRLIKLSVEGFAVDKMAGEVKAFFESHPAP---SAERTIQQCCENILLNAAWLKRDAES 904
S LI+ F+ + +++ F + + S R ++Q E N W+K + E
Sbjct: 898 FSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEV 957
Query: 905 IHQYLLQ 911
+ Q+ +
Sbjct: 958 VLQWFTE 964
>gi|94818891 type 1 tumor necrosis factor receptor shedding
aminopeptidase regulator isoform b [Homo sapiens]
Length = 941
Score = 432 bits (1110), Expect = e-121
Identities = 287/900 (31%), Positives = 449/900 (49%), Gaps = 54/900 (6%)
Query: 53 RLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGD 112
RLP V P++Y L + +L TF G + Q T+ I+++ + I A+
Sbjct: 53 RLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHLQISRATLRKGAG 112
Query: 113 EEIHATGFNYQNE--DEKVTLSFPSTLQTGTG-TLKIDFVGELNDKMKGFYRSKYTTPSG 169
E + E++ L P L G T+ I + G L++ GFY+S Y T G
Sbjct: 113 ERLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEG 172
Query: 170 EVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDEN 229
E+R A TQFE T AR AFPC+DEPA KA+F I + +A+SNM ++ K E
Sbjct: 173 ELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLV--KSVTVAEG 230
Query: 230 LVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTL 289
L+E F T MSTYLVAF++ +++ V +K GV V VY K Q +AL+ A L
Sbjct: 231 LIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLL 290
Query: 290 PFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALV 349
FY+DYF++PYPLPK DL AI DF +GAMENWGL TYRE+ALL D + S +SS+ + +
Sbjct: 291 EFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMT 350
Query: 350 VGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQE 409
V HELAHQWFGNLVTMEWW LWLNEGFA ++E++ V PE + F + A E
Sbjct: 351 VAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCFD-AME 409
Query: 410 LDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQ 469
+DAL++SHP+ V +P+++ E+FD +SY KGA ++ ML +Y+ FK G+ YL K
Sbjct: 410 VDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHS 469
Query: 470 QKNAATEDLWESLENA---------------------------SGKPIAAVMNTWTKQMG 502
KN EDLW+S+ + G + +MNTWT Q G
Sbjct: 470 YKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKG 529
Query: 503 FPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWMVPITISTSEDPNQAKLKILMD 562
FPLI + R + + Q+ + G + W VP+T TS+ + +L
Sbjct: 530 FPLITITVR----GRNVHMKQEHYMKGSDGAPDTGYLWHVPLTFITSKS-DMVHRFLLKT 584
Query: 563 KPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIR--DLSLPPVDRLGLQN 620
K ++ ++ + V +W+K N+G G+Y Y +SL ++ ++ DR L N
Sbjct: 585 KTDVLILPEEV---EWIKFNVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLIN 641
Query: 621 DLFSLARAGIISTVEVLKVMEAFVNEPN-YTVWSDLSCNLGILSTLLSHTDFYEEIQEFV 679
+ F L G +S + L + +E V+ L+ L + L+ D E +F
Sbjct: 642 NAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLN-ELIPMYKLMEKRDMNEVETQFK 700
Query: 680 KDVFSPIGERLGWDPKPGEGHL-DALLRGLVLGKLGKAGHKATLEEARRRFKDHVE--GK 736
+ + + + EG + + +LR +L ++ ++ A F+ E G
Sbjct: 701 AFLIRLLRDLIDKQTWTDEGSVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGN 760
Query: 737 QILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVL 796
L D+ V+ + +G D + ++ + EK++IE L T + +Q +L
Sbjct: 761 LSLPVDVTLAVFAVGAQSTEG--WDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLL 818
Query: 797 TFAL-SEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQ-GGFLISRLIKL 854
+ ++++ Q+ ++ + G + G AW+F++ NW +L +++ G I+ ++
Sbjct: 819 DESFKGDKIKTQEFPQIL-TLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMG 877
Query: 855 SVEGFAVDKMAGEVKAFFESHPAPSAE-RTIQQCCENILLNAAWLKRDAESIHQYLLQRK 913
+ F+ EVK FF S ++ R +QQ E I N W+ ++ + I +L K
Sbjct: 878 TTNQFSTRTRLEEVKGFFSSLKENGSQLRCVQQTIETIEENIGWMDKNFDKIRVWLQSEK 937
>gi|94818901 type 1 tumor necrosis factor receptor shedding
aminopeptidase regulator isoform a [Homo sapiens]
Length = 948
Score = 432 bits (1110), Expect = e-121
Identities = 287/900 (31%), Positives = 449/900 (49%), Gaps = 54/900 (6%)
Query: 53 RLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGD 112
RLP V P++Y L + +L TF G + Q T+ I+++ + I A+
Sbjct: 53 RLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHLQISRATLRKGAG 112
Query: 113 EEIHATGFNYQNE--DEKVTLSFPSTLQTGTG-TLKIDFVGELNDKMKGFYRSKYTTPSG 169
E + E++ L P L G T+ I + G L++ GFY+S Y T G
Sbjct: 113 ERLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEG 172
Query: 170 EVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDEN 229
E+R A TQFE T AR AFPC+DEPA KA+F I + +A+SNM ++ K E
Sbjct: 173 ELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLV--KSVTVAEG 230
Query: 230 LVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTL 289
L+E F T MSTYLVAF++ +++ V +K GV V VY K Q +AL+ A L
Sbjct: 231 LIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLL 290
Query: 290 PFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALV 349
FY+DYF++PYPLPK DL AI DF +GAMENWGL TYRE+ALL D + S +SS+ + +
Sbjct: 291 EFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMT 350
Query: 350 VGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQE 409
V HELAHQWFGNLVTMEWW LWLNEGFA ++E++ V PE + F + A E
Sbjct: 351 VAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCFD-AME 409
Query: 410 LDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQ 469
+DAL++SHP+ V +P+++ E+FD +SY KGA ++ ML +Y+ FK G+ YL K
Sbjct: 410 VDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHS 469
Query: 470 QKNAATEDLWESLENA---------------------------SGKPIAAVMNTWTKQMG 502
KN EDLW+S+ + G + +MNTWT Q G
Sbjct: 470 YKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKG 529
Query: 503 FPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWMVPITISTSEDPNQAKLKILMD 562
FPLI + R + + Q+ + G + W VP+T TS+ + +L
Sbjct: 530 FPLITITVR----GRNVHMKQEHYMKGSDGAPDTGYLWHVPLTFITSKS-DMVHRFLLKT 584
Query: 563 KPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIR--DLSLPPVDRLGLQN 620
K ++ ++ + V +W+K N+G G+Y Y +SL ++ ++ DR L N
Sbjct: 585 KTDVLILPEEV---EWIKFNVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLIN 641
Query: 621 DLFSLARAGIISTVEVLKVMEAFVNEPN-YTVWSDLSCNLGILSTLLSHTDFYEEIQEFV 679
+ F L G +S + L + +E V+ L+ L + L+ D E +F
Sbjct: 642 NAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLN-ELIPMYKLMEKRDMNEVETQFK 700
Query: 680 KDVFSPIGERLGWDPKPGEGHL-DALLRGLVLGKLGKAGHKATLEEARRRFKDHVE--GK 736
+ + + + EG + + +LR +L ++ ++ A F+ E G
Sbjct: 701 AFLIRLLRDLIDKQTWTDEGSVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGN 760
Query: 737 QILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVL 796
L D+ V+ + +G D + ++ + EK++IE L T + +Q +L
Sbjct: 761 LSLPVDVTLAVFAVGAQSTEG--WDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLL 818
Query: 797 TFAL-SEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQ-GGFLISRLIKL 854
+ ++++ Q+ ++ + G + G AW+F++ NW +L +++ G I+ ++
Sbjct: 819 DESFKGDKIKTQEFPQIL-TLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMG 877
Query: 855 SVEGFAVDKMAGEVKAFFESHPAPSAE-RTIQQCCENILLNAAWLKRDAESIHQYLLQRK 913
+ F+ EVK FF S ++ R +QQ E I N W+ ++ + I +L K
Sbjct: 878 TTNQFSTRTRLEEVKGFFSSLKENGSQLRCVQQTIETIEENIGWMDKNFDKIRVWLQSEK 937
>gi|61742777 leucyl/cystinyl aminopeptidase isoform 1 [Homo sapiens]
Length = 1025
Score = 413 bits (1061), Expect = e-115
Identities = 277/880 (31%), Positives = 439/880 (49%), Gaps = 44/880 (5%)
Query: 53 RLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVM-----NCADIDIITASY 107
RLP V P+ Y L L P+L TF G + + Q Q T I++ N + + ++A
Sbjct: 167 RLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVS 226
Query: 108 APEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTG-TLKIDFVGELNDKMKGFYRSKYTT 166
+ E EI ++ Q + + P L G TLKI++ ++ GFY YT
Sbjct: 227 SQEKQAEILEYAYHGQ-----IAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTD 281
Query: 167 PSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPD 226
S E +Y A TQFE AR AFPC+DEPA KATF I ++ + ALSNM +
Sbjct: 282 ESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMP--KKSSVVL 339
Query: 227 DENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAA 286
D+ LV+ +F+ + MSTYLVAF+VGE + ++ +G V +Y K Q +ALE
Sbjct: 340 DDGLVQDEFSESVKMSTYLVAFIVGEMKNL-SQDVNGTLVSIYAVPEKIGQVHYALETTV 398
Query: 287 KTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWV 346
K L F+++YF + YPL K+DL+AI DF AGAMENWGL+T+RE LL D S + R+ V
Sbjct: 399 KLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLV 458
Query: 347 ALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTR 406
++ HELAHQWFGNLVTM+WW LWLNEGFA+++EY ++ F E + F+ A + +
Sbjct: 459 TKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARF-K 517
Query: 407 AQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLT 466
+ D+L++SHPI SV +++E+FD++SY KG+S++ ML Y+ + F+ + +YL
Sbjct: 518 TMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLH 577
Query: 467 KFQQKNAATEDLWESLENASGK--PIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQK 524
+ ++DLW+S + + + +M TWT Q GFPL+ V+ + E L + Q+
Sbjct: 578 NHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQKGFPLVTVQKKGKE----LFIQQE 633
Query: 525 KFCAGGS---YVGEDCPQWMVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKL 581
+F + W +P++ T E N +K + + + + V+ + WVK+
Sbjct: 634 RFFLNMKPEIQPSDTSYLWHIPLSYVT-EGRNYSKYQSVSLLDKKSGVINLTEEVLWVKV 692
Query: 582 NLGTVGFYRTQYSSAMLESLLP--GIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKV 639
N+ G+Y Y+ E+L+ I L DR L N++F LA G + +
Sbjct: 693 NINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAGLGKVPLKRAFDL 752
Query: 640 MEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEG 699
+ NE + ++ ++ LL + + V VF + ++ EG
Sbjct: 753 INYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEG 812
Query: 700 H------LDALLRGLVLGKLGKAGHKATLEEARRRFKDHV--EGKQILSADLRSPVYLTV 751
ALL LG A + F D + G Q L D+ + V+
Sbjct: 813 TPSMRELRSALLEFACTHNLGNCS-----TTAMKLFDDWMASNGTQSLPTDVMTTVFKVG 867
Query: 752 LKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFALSEEVRPQDTVS 811
K G + +L + + EKN+I L ++ + ++ +L+ + +S
Sbjct: 868 AKTDKGWS--FLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQKLS 925
Query: 812 VIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQ-GGFLISRLIKLSVEGFAVDKMAGEVKA 870
I G G AW F+K+NW +L ++ G + I ++ S F+ EV+A
Sbjct: 926 FIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTKTHLSEVQA 985
Query: 871 FFESH-PAPSAERTIQQCCENILLNAAWLKRDAESIHQYL 909
FFE+ A R +Q+ E I LN W++++ +S+ +L
Sbjct: 986 FFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL 1025
>gi|61742775 leucyl/cystinyl aminopeptidase isoform 2 [Homo sapiens]
Length = 1011
Score = 413 bits (1061), Expect = e-115
Identities = 277/880 (31%), Positives = 439/880 (49%), Gaps = 44/880 (5%)
Query: 53 RLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVM-----NCADIDIITASY 107
RLP V P+ Y L L P+L TF G + + Q Q T I++ N + + ++A
Sbjct: 153 RLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVS 212
Query: 108 APEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTG-TLKIDFVGELNDKMKGFYRSKYTT 166
+ E EI ++ Q + + P L G TLKI++ ++ GFY YT
Sbjct: 213 SQEKQAEILEYAYHGQ-----IAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTD 267
Query: 167 PSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPD 226
S E +Y A TQFE AR AFPC+DEPA KATF I ++ + ALSNM +
Sbjct: 268 ESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMP--KKSSVVL 325
Query: 227 DENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAA 286
D+ LV+ +F+ + MSTYLVAF+VGE + ++ +G V +Y K Q +ALE
Sbjct: 326 DDGLVQDEFSESVKMSTYLVAFIVGEMKNL-SQDVNGTLVSIYAVPEKIGQVHYALETTV 384
Query: 287 KTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWV 346
K L F+++YF + YPL K+DL+AI DF AGAMENWGL+T+RE LL D S + R+ V
Sbjct: 385 KLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLV 444
Query: 347 ALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTR 406
++ HELAHQWFGNLVTM+WW LWLNEGFA+++EY ++ F E + F+ A + +
Sbjct: 445 TKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARF-K 503
Query: 407 AQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLT 466
+ D+L++SHPI SV +++E+FD++SY KG+S++ ML Y+ + F+ + +YL
Sbjct: 504 TMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLH 563
Query: 467 KFQQKNAATEDLWESLENASGK--PIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQK 524
+ ++DLW+S + + + +M TWT Q GFPL+ V+ + E L + Q+
Sbjct: 564 NHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQKGFPLVTVQKKGKE----LFIQQE 619
Query: 525 KFCAGGS---YVGEDCPQWMVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKL 581
+F + W +P++ T E N +K + + + + V+ + WVK+
Sbjct: 620 RFFLNMKPEIQPSDTSYLWHIPLSYVT-EGRNYSKYQSVSLLDKKSGVINLTEEVLWVKV 678
Query: 582 NLGTVGFYRTQYSSAMLESLLP--GIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKV 639
N+ G+Y Y+ E+L+ I L DR L N++F LA G + +
Sbjct: 679 NINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAGLGKVPLKRAFDL 738
Query: 640 MEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEG 699
+ NE + ++ ++ LL + + V VF + ++ EG
Sbjct: 739 INYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEG 798
Query: 700 H------LDALLRGLVLGKLGKAGHKATLEEARRRFKDHV--EGKQILSADLRSPVYLTV 751
ALL LG A + F D + G Q L D+ + V+
Sbjct: 799 TPSMRELRSALLEFACTHNLGNCS-----TTAMKLFDDWMASNGTQSLPTDVMTTVFKVG 853
Query: 752 LKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFALSEEVRPQDTVS 811
K G + +L + + EKN+I L ++ + ++ +L+ + +S
Sbjct: 854 AKTDKGWS--FLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQKLS 911
Query: 812 VIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQ-GGFLISRLIKLSVEGFAVDKMAGEVKA 870
I G G AW F+K+NW +L ++ G + I ++ S F+ EV+A
Sbjct: 912 FIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTKTHLSEVQA 971
Query: 871 FFESH-PAPSAERTIQQCCENILLNAAWLKRDAESIHQYL 909
FFE+ A R +Q+ E I LN W++++ +S+ +L
Sbjct: 972 FFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL 1011
>gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo
sapiens]
Length = 1024
Score = 390 bits (1003), Expect = e-108
Identities = 275/899 (30%), Positives = 451/899 (50%), Gaps = 45/899 (5%)
Query: 47 EKRPFE-----RLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADID 101
E+ P+E RL + P++Y+L L + +FTF G++ R AT +V++ + +
Sbjct: 129 EREPWEPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVA 188
Query: 102 IITASYAPE-GDEEIHATGFNYQNEDEKVTLSFPSTLQTGTG-TLKIDFVGELNDKMKGF 159
+ A + + GF + + + + TL LKI + + +++ GF
Sbjct: 189 VEKVQLAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGF 248
Query: 160 YRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVI 219
+RS Y GE R+ VTQF T AR+AFPC+DEP KATF IS+ ++LSNM V
Sbjct: 249 FRSSYVL-HGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPV- 306
Query: 220 DRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGK 279
+++ V F++TP+MSTY +A+ + + + ET +K GV VR+Y +G
Sbjct: 307 -ETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGS 365
Query: 280 --FALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKN 337
+AL + + + FY+DYF VPY LPK+DL+A+ AMENWGL + E +L+DP
Sbjct: 366 GDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSV 425
Query: 338 SCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWT 397
S S V +V+ HE+ HQWFG+LVT WW +WL EGFA + E++ D+ +P +++
Sbjct: 426 SSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEK 485
Query: 398 Q-FVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKD 456
Q F++ LD L +SHP+ V +++D +FD I+Y KGA++IRML +++G
Sbjct: 486 QRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSV 545
Query: 457 FKKGMNMYLTKFQQKNAATEDLWESLENA---SGK--PIAAVMNTWTKQMGFPLIYVEAE 511
F++G+ YLT + NAA DLW +L A +GK I VM+ WT QMG+P+I +
Sbjct: 546 FQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGN 605
Query: 512 QVEDDRLLRLSQKKFCAGGS------YVGEDCPQWMVPITISTSEDPNQAKLKIL-MDKP 564
++R++ ++Q+ F S + + W +P+TI + + I+ +
Sbjct: 606 TTAENRII-ITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNK 664
Query: 565 EMNVVLKNVKPDQWVKLNLGTVGFYRTQYS----SAMLESLLPGIRDLSLPPVDRLGLQN 620
+ + + W+ N+ G++R Y +++ L+ LS+ +R GL +
Sbjct: 665 SEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVS--NRAGLID 722
Query: 621 DLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVK 680
D FSLARAG + L+++ E ++ W S L L LL + Y E++
Sbjct: 723 DAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYIL 782
Query: 681 DVFSPIGERLGWDPKPGEGHL------DALLRGLVLGKLGKAGHKATLEEARRRFKDHV- 733
+ +LGW G L LR V+ G+K ++A D +
Sbjct: 783 KQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWIS 842
Query: 734 EGKQILSADLRSPVYLTVLKHGDGTTLD-IMLKLHKQADMQEEKNRIERVLGATLLPDLI 792
+ + ++R VY T + D + I +K H + E+K +E L + +L+
Sbjct: 843 SNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLE-ALTCSDDRNLL 901
Query: 793 QKVLTFAL-SEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRY-QGGFLISR 850
++L +L SE V QD + VI VA + HGR AWKF +D W+ L RY + F+ S+
Sbjct: 902 NRLLNLSLNSEVVLDQDAIDVIIHVA-RNPHGRDLAWKFFRDKWKILNTRYGEALFMNSK 960
Query: 851 LIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKRDAESIHQYL 909
LI E + E+K F +++ +A + + E + N W + + Q+L
Sbjct: 961 LISGVTEFLNTEGELKELKNFMKNYDGVAA-ASFSRAVETVEANVRWKMLYQDELFQWL 1018
>gi|194239713 laeverin [Homo sapiens]
Length = 990
Score = 300 bits (769), Expect = 3e-81
Identities = 258/918 (28%), Positives = 415/918 (45%), Gaps = 94/918 (10%)
Query: 53 RLPADVSPINYSLCLKPDLL-------DFTFEGKLEAAAQVRQATNQIVMNCADIDIITA 105
RLP + P++Y L L P L F G++ + AT++++++ D A
Sbjct: 97 RLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHSLFQDCERA 156
Query: 106 SY----------APEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTG-TLKIDFVGELND 154
A G + F E + LS P L+ G+ L++ F G + +
Sbjct: 157 EVRGPLSPGTGNATVGRVPVDDVWFALDTEYMVLELSEP--LKPGSSYELQLSFSGLVKE 214
Query: 155 KMK-GFYRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVAL 213
++ G + + YT GE R +Q E T AR FPC+DEPA+KATF+I+++ VAL
Sbjct: 215 DLREGLFLNVYTD-QGERRALLASQLEPTFARYVFPCFDEPALKATFNITMIHHPSYVAL 273
Query: 214 SNMNVIDRKPYPD--DENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTP 271
SNM + + D F+ TP M TYLVAFV+ +YD V R++ G +R++
Sbjct: 274 SNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVN-RTERGKEIRIWAR 332
Query: 272 VGKAEQGK--FALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRET 329
G FAL + F +D FN+ Y LPK D+IA+ F AMENWGL+ + E+
Sbjct: 333 KDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGLMIFDES 392
Query: 330 ALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHC 389
LL++PK+ + + ++ VV HE+ HQWFGNLVTM WW ++WLNEGFAS+ E+ +++
Sbjct: 393 GLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFEVINYF 452
Query: 390 ---FPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIR 446
P +I+ + + R ++ + + ++V SE+ E+FD +YSKGAS+ R
Sbjct: 453 NPKLPRNEIFFSNILHNILR-EDHALVTRAVAMKVENFKTSEIQELFDIFTYSKGASMAR 511
Query: 447 MLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENASG--------KPIAAVMNTWT 498
ML ++ + F + YL F NA +DLW + A I +M++WT
Sbjct: 512 MLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNIMDSWT 571
Query: 499 KQMGFPLIYVEAE----QVEDDRLLRLSQKKFCAGGSYVGEDCPQWMVPITISTSEDPNQ 554
Q GFP+I + + E L + + W+VPI +
Sbjct: 572 HQSGFPVITLNVSTGVMKQEPFYLENIKNRTLLTSND-------TWIVPILWIKN---GT 621
Query: 555 AKLKILMDK-----PEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIR--D 607
+ + +D+ PEM V + WV LNL G+YR Y + L +
Sbjct: 622 TQPLVWLDQSSKVFPEMQV---SDSDHDWVILNLNMTGYYRVNYDKLGWKKLNQQLEKDP 678
Query: 608 LSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLS 667
++P + RL L +D FSL++ I L++ + E VW + NL + L+S
Sbjct: 679 KAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEIIVWHTVLVNL-VTRDLVS 737
Query: 668 HTDFYEEIQEFVKDVFSPIGERLGWDPKP---GEGHL---DALLRGLVLGKLGKAGHKAT 721
+ Y+ + + + L W+ E L D L + L KL
Sbjct: 738 EVNIYDIYSLLKRYLLKRL--NLIWNIYSTIIRENVLALQDDYLALISLEKLFVTACWLG 795
Query: 722 LEEARR-------RFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQE 774
LE+ + ++ DH E + + ++ V + G DI+L + +E
Sbjct: 796 LEDCLQLSKELFAKWVDHPENE--IPYPIKDVVLCYGIALGSDKEWDILLNTYTNTTNKE 853
Query: 775 EKNRIERVLGATLLPDLIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDN 834
EK ++ + + P ++ + + +A+S + ++I VA S+ GR A F+ +N
Sbjct: 854 EKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNETNIIEVVA-SSEVGRYVAKDFLVNN 912
Query: 835 WEELYNRYQGGFLISRLIKLSVEGFAVDKMAGEVKAFF----ESHPAPSAERTIQQCCEN 890
W+ + RY LI+ LI D E++ FF E H +Q
Sbjct: 913 WQAVSKRYGTQSLIN-LIYTIGRTVTTDLQIVELQQFFSNMLEEHQRIRVHANLQTIKNE 971
Query: 891 ILLN-------AAWLKRD 901
L N AAWL+R+
Sbjct: 972 NLKNKKLSARIAAWLRRN 989
>gi|4505029 leukotriene A4 hydrolase [Homo sapiens]
Length = 611
Score = 115 bits (287), Expect = 2e-25
Identities = 106/433 (24%), Positives = 176/433 (40%), Gaps = 25/433 (5%)
Query: 101 DIITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFY 160
D+ G E +A G + + +S P L + I+ E + K
Sbjct: 59 DLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQ-EIVIEISFETSPKSSALQ 117
Query: 161 RSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVID 220
SG+ +Q +A R PC D P++K T+ + VPK+ VAL +
Sbjct: 118 WLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDG 177
Query: 221 RKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKF 280
P P+D + KF + + YL+A VVG +E+R + G V++ + E+ +
Sbjct: 178 ETPDPEDPSRKIYKFIQKVPIPCYLIALVVGA---LESR-QIGPRTLVWSEKEQVEKSAY 233
Query: 281 ALEVAAKTLPFYKDYFNVPYPLPKIDLIAIA-DFAAGAMENWGLVTYRETALLIDPKNSC 339
L +D PY + DL+ + F G MEN +T+ LL K+
Sbjct: 234 EFSETESMLKIAED-LGGPYVWGQYDLLVLPPSFPYGGMEN-PCLTFVTPTLLAGDKS-- 289
Query: 340 SSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQF 399
++ V+ HE++H W GNLVT + W H WLNEG ++E F E
Sbjct: 290 ------LSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNA 343
Query: 400 VSADYTRAQELDALDNSHPIEVSVGHPSEVDE--IFDAISYSKGASVIRMLHDYIGDKDF 457
+ + +HP V +++D + ++ Y KG +++ L +G +
Sbjct: 344 LGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEI 403
Query: 458 KKG-MNMYLTKFQQKNAATEDLWESLENASGKPIAAVM-----NTWTKQMGFPLIYVEAE 511
G + Y+ KF K+ T+D W+ + K V+ N W G P I +
Sbjct: 404 FLGFLKAYVEKFSYKSITTDD-WKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYD 462
Query: 512 QVEDDRLLRLSQK 524
+ + LSQ+
Sbjct: 463 MTLTNACIALSQR 475
>gi|40316915 arginyl aminopeptidase [Homo sapiens]
Length = 650
Score = 82.0 bits (201), Expect = 2e-15
Identities = 74/315 (23%), Positives = 132/315 (41%), Gaps = 24/315 (7%)
Query: 168 SGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDD 227
+G+ + TQ +A R FPC+D PA+K + + VP A+ + + +++ P+
Sbjct: 159 AGKKKPFVYTQGQAVLNRAFFPCFDTPAVKYKYSALIEVPDGFTAVMSASTWEKRG-PN- 216
Query: 228 ENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAK 287
+ F + +YL+A +G+ E + V E+ +E
Sbjct: 217 ----KFFFQMCQPIPSYLIALAIGDLVSAEVGPRSRVWAEPCLIDAAKEEYNGVIEEFLA 272
Query: 288 TLPFYKDYFNVPYPLPKIDLIAIA-DFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWV 346
T + PY + DL+ + F G MEN +T+ LL ++ +
Sbjct: 273 T----GEKLFGPYVWGRYDLLFMPPSFPFGGMEN-PCLTFVTPCLLAGDRS--------L 319
Query: 347 ALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTR 406
A V+ HE++H WFGNLVT W WLNEGF + + F + +
Sbjct: 320 ADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALL 379
Query: 407 AQELDALDNSHP---IEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKD-FKKGMN 462
Q +D +P + V + + D+ ++ Y KG + L +GD+D F +
Sbjct: 380 RQHMDITGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLVGDQDQFDSFLK 439
Query: 463 MYLTKFQQKNAATED 477
Y+ +F+ ++ +D
Sbjct: 440 AYVHEFKFRSILADD 454
>gi|54020718 arginyl aminopeptidase (aminopeptidase B)-like 1 [Homo
sapiens]
Length = 494
Score = 58.5 bits (140), Expect = 3e-08
Identities = 50/198 (25%), Positives = 86/198 (43%), Gaps = 34/198 (17%)
Query: 299 PYPLPKIDLIAIA-DFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQ 357
PY + D++ + F AMEN +T+ +++L S +++ + V HE+AH
Sbjct: 77 PYMWGRYDIVFLPPSFPIVAMEN-PCLTFIISSIL--------ESDEFLVIDVIHEVAHS 127
Query: 358 WFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSH 417
WFGN VT W +WL+EG A+ + + I T+ A +T + LD H
Sbjct: 128 WFGNAVTNATWEEMWLSEGLAT----------YAQRRITTETYGAAFTCLETAFRLDALH 177
Query: 418 PIEVSVGHPSEVDE-------------IFDAISYSKGASVIRMLHDYIGD-KDFKKGMNM 463
+G S V + + + +Y KG + L GD + F +
Sbjct: 178 RQMKLLGEDSPVSKLQVKLEPGVNPSHLMNLFTYEKGYCFVYYLSQLCGDPQRFDDFLRA 237
Query: 464 YLTKFQQKNAATEDLWES 481
Y+ K++ + +DL +S
Sbjct: 238 YVEKYKFTSVVAQDLLDS 255
>gi|4507347 TBP-associated factor 2 [Homo sapiens]
Length = 1199
Score = 47.8 bits (112), Expect = 5e-05
Identities = 83/401 (20%), Positives = 148/401 (36%), Gaps = 58/401 (14%)
Query: 188 FPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVA 247
FPC D + T+ + V VA+SN ++++ Y D + T + ++
Sbjct: 190 FPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETV-YTHDMRKKTFHYMLTIPTAASNIS 248
Query: 248 FVVGEYDFVETRSKDGV---CVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPK 304
+G ++ + V C+ P+ K + FY++ YP
Sbjct: 249 LAIGPFEILVDPYMHEVTHFCLPQLLPLLK-----HTTSYLHEVFEFYEEILTCRYPYSC 303
Query: 305 IDLI----AIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFG 360
+ A + AA A + +A++ID +R+ +A LA Q+FG
Sbjct: 304 FKTVFIDEAYVEVAAYASMSIFSTNLLHSAMIID---ETPLTRRCLA----QSLAQQFFG 356
Query: 361 NLVTMEWWTHLWLNEGFASWIEYLCVDHCF--PEYDIWTQFVSADYTRAQELDA------ 412
++ W+ W+ +G + +I L + F EY W + D A EL
Sbjct: 357 CFISRMSWSDEWVLKGISGYIYGLWMKKTFGVNEYRHWIK-EELDKIVAYELKTGGVLLH 415
Query: 413 --------LDN--SHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMN 462
DN SH + S+ HP + + + K V+R++ + I + + N
Sbjct: 416 PIFGGGKEKDNPASH-LHFSIKHPHTLSWEYYTMFQCKAHLVMRLIENRISMEFMLQVFN 474
Query: 463 MYLT--------KFQ-----QKNAATEDLWESLENASGKPIAAVMNTWTKQMGFPLIYVE 509
L+ KFQ Q +T +S+ N SGK I ++ W Q G Y
Sbjct: 475 KLLSLASTASSQKFQSHMWSQMLVSTSGFLKSISNVSGKDIQPLIKQWVDQSGVVKFYGS 534
Query: 510 AEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWMVPITISTSE 550
+L L K+ Y +++ P+ ++ E
Sbjct: 535 FAFNRKRNVLELEIKQ-----DYTSPGTQKYVGPLKVTVQE 570
>gi|154813197 talpid3 protein [Homo sapiens]
Length = 1472
Score = 35.0 bits (79), Expect = 0.32
Identities = 33/108 (30%), Positives = 50/108 (46%), Gaps = 17/108 (15%)
Query: 543 PITISTSEDPNQAKLKILMDKPEMNVV-LKNVK--PDQWVKLNLGTVGFYRTQYSSAMLE 599
P+T++TS P+ K++ + KP + +V +K+ K P Q L +V SSA +
Sbjct: 697 PVTVTTSIPPSSRKVETGVKKPNIAIVEMKSEKKDPPQLTVQVLPSVDIDSISNSSADVL 756
Query: 600 SLLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEP 647
S L ++ SLPPV I T E++KV E V P
Sbjct: 757 SPLSSPKEASLPPVQTW--------------IKTPEIMKVDEEEVKFP 790
>gi|213513324 hypothetical protein LOC401115 [Homo sapiens]
Length = 139
Score = 32.3 bits (72), Expect = 2.1
Identities = 21/51 (41%), Positives = 26/51 (50%), Gaps = 5/51 (9%)
Query: 3 LAAAAPSLARRLLFLGPPPPPLLLLVFSRS---SRRRLHSLGLAAMPEKRP 50
LA A P R + PPPPPLLLL+ S + +R R G A + RP
Sbjct: 43 LAMAPPPACRSPM--SPPPPPLLLLLLSLALLGARARAEPAGSAVPAQSRP 91
>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 31.6 bits (70), Expect = 3.6
Identities = 36/151 (23%), Positives = 63/151 (41%), Gaps = 18/151 (11%)
Query: 747 VYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQ---------KVLT 797
V+ TV+++ +G L + + M+E + + L A P L++ K T
Sbjct: 667 VHETVVQNAEGYVL--FYRKSSEEAMRERQQVVS--LAAMREPSLLRFYVSREWLNKFNT 722
Query: 798 FALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDN-WEELYNRYQGGFLISRLIKLSV 856
FA + Q + GG+ H + N WE LYNR+ GG ++ L S+
Sbjct: 723 FAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNRFGGGPAVNHLYVCSI 782
Query: 857 EGFAVDKMAG----EVKAFFESHPAPSAERT 883
++ +A E+ F + + A AE +
Sbjct: 783 CQVEIEALAKRRRIEIDTFIKLNKAFQAEES 813
>gi|183397136 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 31.6 bits (70), Expect = 3.6
Identities = 36/151 (23%), Positives = 63/151 (41%), Gaps = 18/151 (11%)
Query: 747 VYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQ---------KVLT 797
V+ TV+++ +G L + + M+E + + L A P L++ K T
Sbjct: 667 VHETVVQNAEGYVL--FYRKSSEEAMRERQQVVS--LAAMREPSLLRFYVSREWLNKFNT 722
Query: 798 FALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDN-WEELYNRYQGGFLISRLIKLSV 856
FA + Q + GG+ H + N WE LYNR+ GG ++ L S+
Sbjct: 723 FAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNRFGGGPAVNHLYVCSI 782
Query: 857 EGFAVDKMAG----EVKAFFESHPAPSAERT 883
++ +A E+ F + + A AE +
Sbjct: 783 CQVEIEALAKRRRIEIDTFIKLNKAFQAEES 813
>gi|183397134 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 31.6 bits (70), Expect = 3.6
Identities = 36/151 (23%), Positives = 63/151 (41%), Gaps = 18/151 (11%)
Query: 747 VYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQ---------KVLT 797
V+ TV+++ +G L + + M+E + + L A P L++ K T
Sbjct: 667 VHETVVQNAEGYVL--FYRKSSEEAMRERQQVVS--LAAMREPSLLRFYVSREWLNKFNT 722
Query: 798 FALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDN-WEELYNRYQGGFLISRLIKLSV 856
FA + Q + GG+ H + N WE LYNR+ GG ++ L S+
Sbjct: 723 FAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNRFGGGPAVNHLYVCSI 782
Query: 857 EGFAVDKMAG----EVKAFFESHPAPSAERT 883
++ +A E+ F + + A AE +
Sbjct: 783 CQVEIEALAKRRRIEIDTFIKLNKAFQAEES 813
>gi|54607018 RYK receptor-like tyrosine kinase isoform 2 [Homo
sapiens]
Length = 607
Score = 31.6 bits (70), Expect = 3.6
Identities = 23/52 (44%), Positives = 27/52 (51%), Gaps = 4/52 (7%)
Query: 19 PPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPD 70
PPPPPLLLL+ + L + G AA P RP E A P + SL L D
Sbjct: 24 PPPPPLLLLL---ALLPLLPAPGAAAAPAPRPPELQSASAGP-SVSLYLSED 71
>gi|54607020 RYK receptor-like tyrosine kinase isoform 1 [Homo
sapiens]
Length = 610
Score = 31.6 bits (70), Expect = 3.6
Identities = 23/52 (44%), Positives = 27/52 (51%), Gaps = 4/52 (7%)
Query: 19 PPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPD 70
PPPPPLLLL+ + L + G AA P RP E A P + SL L D
Sbjct: 24 PPPPPLLLLL---ALLPLLPAPGAAAAPAPRPPELQSASAGP-SVSLYLSED 71
>gi|157426891 endothelin converting enzyme-like 1 [Homo sapiens]
Length = 775
Score = 30.8 bits (68), Expect = 6.1
Identities = 22/92 (23%), Positives = 39/92 (42%), Gaps = 22/92 (23%)
Query: 332 LIDPKNSCSSSRQWVALVVGHELAHQW---------FGNLVTMEWWTHLWLNEGFASWIE 382
L DP S + + ++GHEL H + GNL + WWT AS+
Sbjct: 592 LYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNL--LHWWTE-------ASYSR 642
Query: 383 YL----CVDHCFPEYDIWTQFVSADYTRAQEL 410
+L C+ + + ++ Q V+ +T + +
Sbjct: 643 FLRKAECIVRLYDNFTVYNQRVNGKHTLGENI 674
>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
Length = 828
Score = 30.4 bits (67), Expect = 7.9
Identities = 27/96 (28%), Positives = 43/96 (44%), Gaps = 21/96 (21%)
Query: 771 DMQEEKNRIERVLGATLLPDLIQ---------KVLTFALSEEVRPQDTVSVIGGVAGGSK 821
+ Q+E+ RI +L + P L+Q K TFA + D + + GGV
Sbjct: 710 EAQKERRRISNLLNI-MEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPP--- 765
Query: 822 HGRKAAW------KFIKDNWEELYNRYQGGFLISRL 851
RKA + ++ W+ LY+RY GG ++ L
Sbjct: 766 --RKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHL 799
>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
Length = 942
Score = 30.4 bits (67), Expect = 7.9
Identities = 27/96 (28%), Positives = 43/96 (44%), Gaps = 21/96 (21%)
Query: 771 DMQEEKNRIERVLGATLLPDLIQ---------KVLTFALSEEVRPQDTVSVIGGVAGGSK 821
+ Q+E+ RI +L + P L+Q K TFA + D + + GGV
Sbjct: 718 EAQKERRRISNLLNI-MEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPP--- 773
Query: 822 HGRKAAW------KFIKDNWEELYNRYQGGFLISRL 851
RKA + ++ W+ LY+RY GG ++ L
Sbjct: 774 --RKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHL 807
>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
Length = 911
Score = 30.4 bits (67), Expect = 7.9
Identities = 27/96 (28%), Positives = 43/96 (44%), Gaps = 21/96 (21%)
Query: 771 DMQEEKNRIERVLGATLLPDLIQ---------KVLTFALSEEVRPQDTVSVIGGVAGGSK 821
+ Q+E+ RI +L + P L+Q K TFA + D + + GGV
Sbjct: 687 EAQKERRRISNLLNI-MEPSLLQFYISRQWLNKFKTFAEPGPISNNDFLCIHGGVPP--- 742
Query: 822 HGRKAAW------KFIKDNWEELYNRYQGGFLISRL 851
RKA + ++ W+ LY+RY GG ++ L
Sbjct: 743 --RKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVNHL 776
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,664,635
Number of Sequences: 37866
Number of extensions: 1600847
Number of successful extensions: 3814
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 3704
Number of HSP's gapped (non-prelim): 35
length of query: 919
length of database: 18,247,518
effective HSP length: 111
effective length of query: 808
effective length of database: 14,044,392
effective search space: 11347868736
effective search space used: 11347868736
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.