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Search of human proteins with 157952215
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157952215 protein tyrosine phosphatase, receptor type, B
isoform a [Homo sapiens]
(2215 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157952215 protein tyrosine phosphatase, receptor type, B isof... 4482 0.0
gi|157952213 protein tyrosine phosphatase, receptor type, B isof... 4009 0.0
gi|148728162 protein tyrosine phosphatase, receptor type, J isof... 428 e-119
gi|4506323 receptor-type protein tyrosine phosphatase O isoform ... 306 2e-82
gi|13677220 receptor-type protein tyrosine phosphatase O isoform... 303 1e-81
gi|13677216 receptor-type protein tyrosine phosphatase O isoform... 303 1e-81
gi|13677222 receptor-type protein tyrosine phosphatase O isoform... 297 9e-80
gi|13677218 receptor-type protein tyrosine phosphatase O isoform... 297 9e-80
gi|13677214 receptor-type protein tyrosine phosphatase O isoform... 297 9e-80
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 296 2e-79
gi|241896926 protein tyrosine phosphatase, receptor type, H isof... 280 9e-75
gi|241896924 protein tyrosine phosphatase, receptor type, H isof... 280 9e-75
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 252 2e-66
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 251 7e-66
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 246 2e-64
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 246 2e-64
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 246 2e-64
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 245 4e-64
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 245 4e-64
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 243 2e-63
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 243 2e-63
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 238 5e-62
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 238 5e-62
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 238 5e-62
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 235 3e-61
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 235 3e-61
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 233 1e-60
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 233 1e-60
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 233 2e-60
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 233 2e-60
>gi|157952215 protein tyrosine phosphatase, receptor type, B isoform a
[Homo sapiens]
Length = 2215
Score = 4482 bits (11626), Expect = 0.0
Identities = 2215/2215 (100%), Positives = 2215/2215 (100%)
Query: 1 MEAEFYMVILTCLIFRNSEGFQIVHVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDEKL 60
MEAEFYMVILTCLIFRNSEGFQIVHVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDEKL
Sbjct: 1 MEAEFYMVILTCLIFRNSEGFQIVHVQKQQCLFKNEKVVVGSCNRTIQNQQWMWTEDEKL 60
Query: 61 LHVKSALCLAISNSSRGPSRSAILDRCSQAPRWTCYDQEGFLEVENASLFLQKQGSRVVV 120
LHVKSALCLAISNSSRGPSRSAILDRCSQAPRWTCYDQEGFLEVENASLFLQKQGSRVVV
Sbjct: 61 LHVKSALCLAISNSSRGPSRSAILDRCSQAPRWTCYDQEGFLEVENASLFLQKQGSRVVV 120
Query: 121 KKARKYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSVRSTRNTAPPQILTTFNAVPDG 180
KKARKYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSVRSTRNTAPPQILTTFNAVPDG
Sbjct: 121 KKARKYLHSWMKIDVNKEGKLVNESLCLQKAGLGAEVSVRSTRNTAPPQILTTFNAVPDG 180
Query: 181 LVFLIRNTTEAFIRNAAENYSQNSSERQHPNLHMTGITDTSWVLSTTQPFSSTTEETGLA 240
LVFLIRNTTEAFIRNAAENYSQNSSERQHPNLHMTGITDTSWVLSTTQPFSSTTEETGLA
Sbjct: 181 LVFLIRNTTEAFIRNAAENYSQNSSERQHPNLHMTGITDTSWVLSTTQPFSSTTEETGLA 240
Query: 241 EPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNL 300
EPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNL
Sbjct: 241 EPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNL 300
Query: 301 QDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSY 360
QDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSY
Sbjct: 301 QDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSY 360
Query: 361 EVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTV 420
EVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTV
Sbjct: 361 EVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTV 420
Query: 421 PSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTP 480
PSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTP
Sbjct: 421 PSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTP 480
Query: 481 GYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNI 540
GYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNI
Sbjct: 481 GYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNI 540
Query: 541 TLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVAN 600
TLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVAN
Sbjct: 541 TLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVAN 600
Query: 601 LEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGR 660
LEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGR
Sbjct: 601 LEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGR 660
Query: 661 QYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLA 720
QYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLA
Sbjct: 661 QYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLA 720
Query: 721 DRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHV 780
DRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHV
Sbjct: 721 DRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHV 780
Query: 781 ANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVV 840
ANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVV
Sbjct: 781 ANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVV 840
Query: 841 VTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLSHDG 900
VTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLSHDG
Sbjct: 841 VTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLSHDG 900
Query: 901 KVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGVSVSNS 960
KVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGVSVSNS
Sbjct: 901 KVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGVSVSNS 960
Query: 961 ARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTT 1020
ARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTT
Sbjct: 961 ARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTT 1020
Query: 1021 KSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVFP 1080
KSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVFP
Sbjct: 1021 KSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVFP 1080
Query: 1081 PFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATD 1140
PFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATD
Sbjct: 1081 PFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATD 1140
Query: 1141 SLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGS 1200
SLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGS
Sbjct: 1141 SLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGS 1200
Query: 1201 LKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTS 1260
LKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTS
Sbjct: 1201 LKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTS 1260
Query: 1261 EPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLS 1320
EPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLS
Sbjct: 1261 EPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLS 1320
Query: 1321 FRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGELS 1380
FRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGELS
Sbjct: 1321 FRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGELS 1380
Query: 1381 NESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKENWKDK 1440
NESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKENWKDK
Sbjct: 1381 NESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKENWKDK 1440
Query: 1441 DLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSLAITWK 1500
DLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSLAITWK
Sbjct: 1441 DLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSLAITWK 1500
Query: 1501 GPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKT 1560
GPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKT
Sbjct: 1501 GPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKT 1560
Query: 1561 YSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRK 1620
YSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRK
Sbjct: 1561 YSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRK 1620
Query: 1621 LEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDV 1680
LEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDV
Sbjct: 1621 LEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDV 1680
Query: 1681 LISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRHNASIR 1740
LISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRHNASIR
Sbjct: 1681 LISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRHNASIR 1740
Query: 1741 VYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIR 1800
VYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIR
Sbjct: 1741 VYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIR 1800
Query: 1801 AFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSAGLFLIGMLVAVVALLIC 1860
AFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSAGLFLIGMLVAVVALLIC
Sbjct: 1801 AFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSAGLFLIGMLVAVVALLIC 1860
Query: 1861 RQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYL 1920
RQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYL
Sbjct: 1861 RQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYL 1920
Query: 1921 LSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASY 1980
LSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASY
Sbjct: 1921 LSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASY 1980
Query: 1981 IPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDS 2040
IPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDS
Sbjct: 1981 IPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDS 2040
Query: 2041 LYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQ 2100
LYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQ
Sbjct: 2041 LYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQ 2100
Query: 2101 FVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLH 2160
FVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLH
Sbjct: 2101 FVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLH 2160
Query: 2161 RVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRDPVYSRH 2215
RVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRDPVYSRH
Sbjct: 2161 RVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRDPVYSRH 2215
>gi|157952213 protein tyrosine phosphatase, receptor type, B isoform b
precursor [Homo sapiens]
Length = 1997
Score = 4009 bits (10398), Expect = 0.0
Identities = 1979/1980 (99%), Positives = 1980/1980 (100%)
Query: 236 ETGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTT 295
+TGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTT
Sbjct: 18 QTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTT 77
Query: 296 YGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSG 355
YGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSG
Sbjct: 78 YGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSG 137
Query: 356 KVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYT 415
KVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYT
Sbjct: 138 KVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYT 197
Query: 416 NGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAF 475
NGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAF
Sbjct: 198 NGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAF 257
Query: 476 HGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNV 535
HGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNV
Sbjct: 258 HGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNV 317
Query: 536 DSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFP 595
DSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFP
Sbjct: 318 DSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFP 377
Query: 596 DKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTG 655
DKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTG
Sbjct: 378 DKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTG 437
Query: 656 LVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKY 715
LVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKY
Sbjct: 438 LVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKY 497
Query: 716 IISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQV 775
IISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQV
Sbjct: 498 IISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQV 557
Query: 776 TDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGS 835
TDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGS
Sbjct: 558 TDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGS 617
Query: 836 LYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVT 895
LYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVT
Sbjct: 618 LYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVT 677
Query: 896 LSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGV 955
LSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGV
Sbjct: 678 LSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGV 737
Query: 956 SVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYS 1015
SVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYS
Sbjct: 738 SVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYS 797
Query: 1016 VTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFND 1075
VTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFND
Sbjct: 798 VTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFND 857
Query: 1076 MKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISP 1135
MKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISP
Sbjct: 858 MKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISP 917
Query: 1136 NGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIA 1195
NGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIA
Sbjct: 918 NGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIA 977
Query: 1196 SVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGIL 1255
SVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGIL
Sbjct: 978 SVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGIL 1037
Query: 1256 LRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENS 1315
LRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENS
Sbjct: 1038 LRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENS 1097
Query: 1316 TRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTH 1375
TRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTH
Sbjct: 1098 TRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTH 1157
Query: 1376 SGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKE 1435
SGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKE
Sbjct: 1158 SGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKE 1217
Query: 1436 NWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSL 1495
NWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSL
Sbjct: 1218 NWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSL 1277
Query: 1496 AITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSG 1555
AITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSG
Sbjct: 1278 AITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSG 1337
Query: 1556 DSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEV 1615
DSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEV
Sbjct: 1338 DSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEV 1397
Query: 1616 EFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRV 1675
EFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRV
Sbjct: 1398 EFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRV 1457
Query: 1676 NEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRH 1735
NEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRH
Sbjct: 1458 NEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRH 1517
Query: 1736 NASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAY 1795
NASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAY
Sbjct: 1518 NASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAY 1577
Query: 1796 RISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSAGLFLIGMLVAVV 1855
RISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSAGLFLIGMLVAVV
Sbjct: 1578 RISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSAGLFLIGMLVAVV 1637
Query: 1856 ALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQA 1915
ALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQA
Sbjct: 1638 ALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQA 1697
Query: 1916 DSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDY 1975
DSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDY
Sbjct: 1698 DSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDY 1757
Query: 1976 INASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWP 2035
INASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWP
Sbjct: 1758 INASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWP 1817
Query: 2036 ADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETT 2095
ADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETT
Sbjct: 1818 ADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETT 1877
Query: 2096 QSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVH 2155
QSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVH
Sbjct: 1878 QSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVH 1937
Query: 2156 DLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRDPVYSRH 2215
DLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRDPVYSRH
Sbjct: 1938 DLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRDPVYSRH 1997
>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
precursor [Homo sapiens]
Length = 1337
Score = 428 bits (1101), Expect = e-119
Identities = 371/1290 (28%), Positives = 579/1290 (44%), Gaps = 154/1290 (11%)
Query: 968 VSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEA 1027
++W Y+ +K+K +T ++ + C L P Y ++T G
Sbjct: 137 LTWKSNDTAASEYKYVVKHKMENEKTITVVH-QPWCNITGLRPATSYVFSITPGIGN--- 192
Query: 1028 NEQGNGRTI-----PEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPF 1082
G+ R I P PV DL + ++WS NG ++L +
Sbjct: 193 ETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTAS---CRVLLESIGSHEEL 249
Query: 1083 HLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSL 1142
++ + + L PG QY I + + K + G D+
Sbjct: 250 -TQDSRLQVNISGLKPGVQYNINPYLLQSN--------------KTKGDPLGTEGGLDAS 294
Query: 1143 TVNWTPGGGDV----DSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIAS-- 1196
+ G D V S S+ E LE G +Y + S
Sbjct: 295 NTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDT-----EVLLVGLEPGTRYNATVYSQA 349
Query: 1197 VSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAER---YDILLLTENG 1253
+G+ + RT V V A N S+ SL + W+ + + Y I + E
Sbjct: 350 ANGTEGQPQAIEFRTNAIQVFDVTAVNI-SATSLTLIWKVSDNESSSNYTYKIHVAGETD 408
Query: 1254 ILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITE 1313
N SEP L Y I + V G + + T P V+D R+T
Sbjct: 409 SSNLNVSEPRAV----IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTV 464
Query: 1314 NSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIV 1373
ST + W++ + E +I +G R ++ QS L G Y IV
Sbjct: 465 VSTTEIGLAWSSHDAESFQMHI---TQEGAGNSRVEITTN-QSIIIGGLFPGTKYCFEIV 520
Query: 1374 TH--SGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDF-YELILYNPN 1430
+G + RTVP++V + TT+ +W +W G ++ Y L++ + +
Sbjct: 521 PKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTE-MWLDWKSPDGASEYVYHLVIESKH 579
Query: 1431 GTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAP-SPPSLMSFAD 1489
G+ + DK +T QGL+PG L+ +T S ++ + + TA + PS +S D
Sbjct: 580 GSNHTSTYDKAIT---LQGLIPG---TLYNITISPEVDHVWGDPNSTAQYTRPSNVSNID 633
Query: 1490 IANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYG---------- 1539
++ + A T W +++D + + N + ++V
Sbjct: 634 VSTNTTAATLS----WQNFDDASPTY---SYCLLIEKAGNSSNATQVVTDIGITDATVTE 686
Query: 1540 LRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRP-QNSTAIACSWIPPDS 1598
L PG SY + GD K+ +P S T P + + C A+ W P
Sbjct: 687 LIPGSSYTVEIFAQVGDGIKSL-EPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPG 745
Query: 1599 DFDGYSIECRK--------MDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGM 1650
G+ +E +++ E + E + LN Y +SI S G
Sbjct: 746 ANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFST-----SYNISITTVSCGK 800
Query: 1651 TSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVV 1710
+ ++ T I PPPP + +S +S+ V S F ++G +K + V++
Sbjct: 801 MAAPTRNTCTTGITDPPPPDGSPNITS----VSHNSVK--VKFSGFEASHGPIKAYAVIL 854
Query: 1711 READGSDELKPEQQHPLPSYLEYRHNASIRVYQTNY--FASKCAENPNSNSKS----FNI 1764
+ HP L+Y + + Y + + E S S S + I
Sbjct: 855 TTGEAG--------HPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEI 906
Query: 1765 KLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLF----DEDLKEFTKPLYSD 1820
+G E +LG + +G L+P +YR + FT + ++ L + + S
Sbjct: 907 DVGNESTTLG---------YYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSF 957
Query: 1821 TFFSLPITTESEP--LFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIR 1878
+ +S ++ +P + GA+ G G +I V V + R+K ++ + +S
Sbjct: 958 SRYSDAVSLPQDPGVICGAVFGCIFGALVI---VTVGGFIFWRKK---RKDAKNNEVSFS 1011
Query: 1879 RDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCD 1938
+ +P K S I++ FE +F K QADSN ++EYE+LK VG +Q
Sbjct: 1012 QIKP-------------KKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKY 1058
Query: 1939 IALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLP 1998
A L ENRGKNRYNN+LPYD +RVKLS V DYINA+Y+PG + ++++I TQGPLP
Sbjct: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
Query: 1999 GTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPE 2058
T DFW+MVWE+NV+ I+M+T+CVE+GR KC+ YWP+ Q + YGD+ + M SE VLPE
Sbjct: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ-AQDYGDITVAMTSEIVLPE 1176
Query: 2059 WTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPT 2118
WTIR+F + + ++H L R FH+T WPDHGVP+TT LI F VRDY+ +SP P
Sbjct: 1177 WTIRDFTVKNIQTSESHPL-RQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPI 1235
Query: 2119 VVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 2178
+VHCSAGVGRTGTFIA+DR++ Q++++++VD+YG V+DLR+HR MVQTE QYV+L+QCV
Sbjct: 1236 LVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCV 1295
Query: 2179 RDVLRARKLRS----EQENPLFPIYENVNP 2204
D++R++K Q IYEN+ P
Sbjct: 1296 LDIVRSQKDSKVDLIYQNTTAMTIYENLAP 1325
Score = 62.8 bits (151), Expect = 4e-09
Identities = 136/647 (21%), Positives = 247/647 (38%), Gaps = 109/647 (16%)
Query: 298 CNLQDLQAGTIYNFRII------SLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWT 351
CN+ L+ T Y F I + + R + + T+P+P + V+ +L W+
Sbjct: 171 CNITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALS--WS 228
Query: 352 PSSGKVTSYEV-QLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRS 410
+G + + + + + Q ++Q + S L G +YNI + K
Sbjct: 229 NGNGTASCRVLLESIGSHEELTQDSRLQVNIS-------GLKPGVQYNINPYLLQSNK-- 279
Query: 411 FSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRL-----MLMDKGILVHGGV 465
TK + L + N ER R + D+ ++ G
Sbjct: 280 --------------------TKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLV---GP 316
Query: 466 VDKHA------TSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLV--RTAPMEVSNLKVTN 517
VD + T GL PG YN TV ++AA + + + RT ++V ++ N
Sbjct: 317 VDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVN 376
Query: 518 DGSLTSLKVKWQ--------------RPPGNVDSYNITLSHKGTIKESRVLAPWITETHF 563
S TSL + W+ G DS N+ +S E R + P + + F
Sbjct: 377 I-SATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVS------EPRAVIPGLRSSTF 429
Query: 564 KELVPGRLYQVTVSCVSGELSAQKMAVG-RTFPDKVANLEANNNGRMRSLVVSWSPPAGD 622
Y +TV V G++ + T P V++ + ++WS + D
Sbjct: 430 --------YNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTE-IGLAWS--SHD 478
Query: 623 WEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVE--SGNLKNSERCQ 680
E +++ + + + + ++ + GL PG +Y E++ + +G S
Sbjct: 479 AESFQMHITQEGAGNSRVEITTNQSIII---GGLFPGTKYCFEIVPKGPNGTEGASRTVC 535
Query: 681 GRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTF 740
RTVP AV + V + T + + W++P E Y+ L + + + D K T
Sbjct: 536 NRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASE-YVYHLVIESKHGSNHTSTYD-KAITL 593
Query: 741 TDLVPGRKYMATVT-SISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGD 799
L+PG Y T++ + + +S T P+ V+++ V+ T++ +W
Sbjct: 594 QGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTN--TTAATLSWQNFDDA 651
Query: 800 VEFYQVLLIHENVVIKNESISSET----SRYSFHSLKSGSLYSV-VVTTVSGGISSRQVV 854
Y L+ E + + T + + L GS Y+V + V GI S +
Sbjct: 652 SPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLE-- 709
Query: 855 VEGR----TVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLS 897
GR T P+S++ + L + W PG +E+ +S
Sbjct: 710 -PGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVS 755
Score = 59.7 bits (143), Expect = 3e-08
Identities = 143/685 (20%), Positives = 262/685 (38%), Gaps = 81/685 (11%)
Query: 676 SERCQGRTVPLAVLQLRVKHANETSLSIMWQT--PVAEWEKYIISLA---DRDLLLIHKS 730
S++ T P V ++ + T++ + W++ A KY++ ++ + ++H+
Sbjct: 110 SQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQP 169
Query: 731 LSKDAKEFTFTDLVPGRKYMATVTSISGDLK--NSSSVKGRTVPAQVTDLHVANQGMTSS 788
T L P Y+ ++T G+ + +K T P V+DL VA G+ +
Sbjct: 170 WCN------ITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKA 223
Query: 789 LFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGI 848
+ W+ G +VLL E++ E + + LK G Y++ +
Sbjct: 224 ALS-WSNGNGTASC-RVLL--ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
Query: 849 SSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAP-------GDVDNYEVTLSHDGK 901
+ + + G+ +N+ R+ S + AP G VD S D +
Sbjct: 280 TKGDPL-------GTEGGLDASNTERSRAGSPT---APVHDESLVGPVDPSSGQQSRDTE 329
Query: 902 VVQSLVIAKSVRECSFSSLTPGRLYTVTITTRS-----GKYENHSFSQERTVPDKVQGVS 956
V+ L PG Y T+ +++ G+ + F V V+
Sbjct: 330 VL-------------LVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVN 376
Query: 957 VSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSV 1016
+S ++ + +VS ++ ++ Y++ + + + + ++ SE V L Y++
Sbjct: 377 ISATSLTLIWKVSDNESSSNYT-YKIHVAGETD---SSNLNVSEPRAVIPGLRSSTFYNI 432
Query: 1017 TVTTKSGQYEANEQG-NGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEI-QLLFN 1074
TV G E T P PV D + ST ++ + WS + + Q I Q
Sbjct: 433 TVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAG 492
Query: 1075 DMKVFPPFHLVNTATEYRFTSLTPGRQY--KILVLTISGDVQQSAFIEGFTVPSAVKNIH 1132
+ +V + T L PG +Y +I+ +G S + TVPSAV +IH
Sbjct: 493 NSRV-----EITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIH 547
Query: 1133 ISPNGATDSLTVNW-TPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQ 1191
+ T + ++W +P G Y + + T K + T L G Y
Sbjct: 548 V-VYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAI---TLQGLIPGTLYN 603
Query: 1192 IMIASVSGSLKNQINVVGR-TVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLT 1250
I I+ + N + T P++V + D + ++ + +SWQ + Y LL
Sbjct: 604 ITISPEVDHVWGDPNSTAQYTRPSNVSNI--DVSTNTTAATLSWQNFDDASPTYSYCLLI 661
Query: 1251 ENGILLRNTSEPAT---TKQHKFEDLTPGKKYKIQILT-VSGGLFSKE-AQTEGRTVPAA 1305
E N ++ T +L PG Y ++I V G+ S E + T PA+
Sbjct: 662 EKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPAS 721
Query: 1306 VT--DLRITENSTRHLSFRWTASEG 1328
+ D + L +WT G
Sbjct: 722 MASFDCEVVPKEPA-LVLKWTCPPG 745
Score = 58.2 bits (139), Expect = 9e-08
Identities = 120/579 (20%), Positives = 228/579 (39%), Gaps = 75/579 (12%)
Query: 300 LQDLQAGTIYNFRIISL------DEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPS 353
L L+ GT YN + S + + + +T+ + F V+ ++TSL + W S
Sbjct: 332 LVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQV--FDVTAVNISATSLTLIWKVS 389
Query: 354 SGKVTS---YEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRS 410
+ +S Y++ + E + + + E + L + + YNI + V G
Sbjct: 390 DNESSSNYTYKIHVAGETDSS--NLNVSEPRA----VIPGLRSSTFYNITVCPVLGDIEG 443
Query: 411 FSVYTNGSTVPSPVKDIGISTKANSLL-ISWSHGSGNVERYRLMLMDKGILVHGGVVDKH 469
+ T P PV D ++ + + + ++WS S + E +++ + +G + V
Sbjct: 444 TPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWS--SHDAESFQMHITQEG-AGNSRVEITT 500
Query: 470 ATSYAFHGLTPGYLYNLTVM------TEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTS 523
S GL PG Y ++ TE A R RT P V ++ V + T
Sbjct: 501 NQSIIIGGLFPGTKYCFEIVPKGPNGTEGAS----RTVCNRTVPSAVFDIHVVY-VTTTE 555
Query: 524 LKVKWQRPPGNVD-SYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGE 582
+ + W+ P G + Y++ + K + IT + L+PG LY +T+S
Sbjct: 556 MWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAIT---LQGLIPGTLYNITISPEVDH 612
Query: 583 LSAQKMAVGR-TFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNIT 641
+ + + T P V+N++ + N +L W+ + S LL
Sbjct: 613 VWGDPNSTAQYTRPSNVSNIDVSTNTTAATL---------SWQNFDDASPTYSYCLLIEK 663
Query: 642 VGKEE--TQYVMD-------DTGLVPGRQYEVEVIVESGN-LKNSE--RCQGRTVPLAVL 689
G TQ V D T L+PG Y VE+ + G+ +K+ E R T P ++
Sbjct: 664 AGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMA 723
Query: 690 QLRVKHA-NETSLSIMWQTPV---AEWEKYIISLADRDLLLIHKSLSKDAKEF--TFTDL 743
+ E +L + W P A +E + S A + + S++ E+ T L
Sbjct: 724 SFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYL 783
Query: 744 VPGRKYMATVTSIS-----GDLKN--SSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQA 796
Y ++T++S +N ++ + P ++ + F+ + +
Sbjct: 784 NFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEAS 843
Query: 797 QGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGS 835
G ++ Y V+L + S++ +Y++ K G+
Sbjct: 844 HGPIKAYAVIL----TTGEAGHPSADVLKYTYEDFKKGA 878
Score = 37.4 bits (85), Expect = 0.16
Identities = 79/348 (22%), Positives = 141/348 (40%), Gaps = 51/348 (14%)
Query: 1475 SRTAPSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALT---VFNPYNNRK 1531
S T PSP + I+ T++ +TWK + ++ + T V P+ N
Sbjct: 115 SSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCN-- 172
Query: 1532 SEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIAC 1591
+ GLRP SY F++ G+ +T+ P V T+P + +L A
Sbjct: 173 -----ITGLRPATSYVFSITPGIGN--ETWGDPRVIKVITEPIPVSDLRVALTGVRKAAL 225
Query: 1592 SWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKEKSL-LNIMMLVPHKRY------LVSIK 1644
SW S+ +G + CR + + + +L ++ L +NI L P +Y L S K
Sbjct: 226 SW----SNGNG-TASCRVL-LESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
Query: 1645 VQSAGMTSEVVEDSTITMIDR--PPPPPPHIR--VNEKDVLISKSSINFTVNCSWFSDTN 1700
+ + +E D++ T R P P H V D + S + V
Sbjct: 280 TKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDTEV---LLVGLE 336
Query: 1701 GAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRHNASIRVYQ---TNYFAS------KC 1751
+Y V +A E +P+ +E+R NA I+V+ N A+ K
Sbjct: 337 PGTRYNATVYSQAANGTEGQPQA-------IEFRTNA-IQVFDVTAVNISATSLTLIWKV 388
Query: 1752 AENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISI 1799
++N +S++ ++ I + E +S + ++ + L+ T Y I++
Sbjct: 389 SDNESSSNYTYKIHVAGETDS--SNLNVSEPRAVIPGLRSSTFYNITV 434
>gi|4506323 receptor-type protein tyrosine phosphatase O isoform b
precursor [Homo sapiens]
Length = 1188
Score = 306 bits (783), Expect = 2e-82
Identities = 177/423 (41%), Positives = 252/423 (59%), Gaps = 27/423 (6%)
Query: 1789 LKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSA-GLFL 1847
L P TAY S+ +F+ P + TE P I ++ L
Sbjct: 783 LLPATAYNCSVTSFSH---------DSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLL 833
Query: 1848 IGMLVAVVALLICRQK-VSHGRERPSARL----SIRRDRPLSVHLNLGQKGNRKTSCPIK 1902
IG+L+ V L+I R+K + RE + S+ RD L + + RK + P++
Sbjct: 834 IGLLL--VTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQ 891
Query: 1903 INQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRV 1962
++ F+ + + DS+Y S ++EELK +G + A LP NR KNRY NILPYD +RV
Sbjct: 892 LDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRV 951
Query: 1963 KLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQC 2022
+L +++++ +DYINA+YIPG N +EYI TQGPLP T++DFWKMV +Q IVM+TQC
Sbjct: 952 RLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQC 1011
Query: 2023 VEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFH 2082
EK RVKCDHYWP ++ + YGD+ ++M+SE +W R F+I D + + HF+
Sbjct: 1012 NEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI---NYADEMQDVMHFN 1068
Query: 2083 YTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQ 2140
YT WPDHGVP +S++QFV VR +S GP ++HCSAGVGRTGTFIALDR+LQ
Sbjct: 1069 YTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDRLLQ 1126
Query: 2141 QLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYE 2200
+ + VDI G V ++R +R+ MVQTE QY+++HQCV+ + +K +Q IYE
Sbjct: 1127 HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK---QQFCISDVIYE 1183
Query: 2201 NVN 2203
NV+
Sbjct: 1184 NVS 1186
>gi|13677220 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 303 bits (776), Expect = 1e-81
Identities = 165/364 (45%), Positives = 234/364 (64%), Gaps = 17/364 (4%)
Query: 1847 LIGMLVAVVALLICRQK-VSHGRERPSARL----SIRRDRPLSVHLNLGQKGNRKTSCPI 1901
LIG+L+ V L+I R+K + RE + S+ RD L + + RK + P+
Sbjct: 22 LIGLLL--VTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPV 79
Query: 1902 KINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATR 1961
+++ F+ + + DS+Y S ++EELK +G + A LP NR KNRY NILPYD +R
Sbjct: 80 QLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSR 139
Query: 1962 VKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQ 2021
V+L +++++ +DYINA+YIPG N +EYI TQGPLP T++DFWKMV +Q IVM+TQ
Sbjct: 140 VRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQ 199
Query: 2022 CVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHF 2081
C EK RVKCDHYWP ++ + YGD+ ++M+SE +W R F+I D + + HF
Sbjct: 200 CNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI---NYADEMQDVMHF 256
Query: 2082 HYTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRIL 2139
+YT WPDHGVP +S++QFV VR +S GP ++HCSAGVGRTGTFIALDR+L
Sbjct: 257 NYTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDRLL 314
Query: 2140 QQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIY 2199
Q + + VDI G V ++R +R+ MVQTE QY+++HQCV+ + +K +Q IY
Sbjct: 315 QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK---QQFCISDVIY 371
Query: 2200 ENVN 2203
ENV+
Sbjct: 372 ENVS 375
>gi|13677216 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 303 bits (776), Expect = 1e-81
Identities = 165/364 (45%), Positives = 234/364 (64%), Gaps = 17/364 (4%)
Query: 1847 LIGMLVAVVALLICRQK-VSHGRERPSARL----SIRRDRPLSVHLNLGQKGNRKTSCPI 1901
LIG+L+ V L+I R+K + RE + S+ RD L + + RK + P+
Sbjct: 22 LIGLLL--VTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPV 79
Query: 1902 KINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATR 1961
+++ F+ + + DS+Y S ++EELK +G + A LP NR KNRY NILPYD +R
Sbjct: 80 QLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSR 139
Query: 1962 VKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQ 2021
V+L +++++ +DYINA+YIPG N +EYI TQGPLP T++DFWKMV +Q IVM+TQ
Sbjct: 140 VRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQ 199
Query: 2022 CVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHF 2081
C EK RVKCDHYWP ++ + YGD+ ++M+SE +W R F+I D + + HF
Sbjct: 200 CNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI---NYADEMQDVMHF 256
Query: 2082 HYTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRIL 2139
+YT WPDHGVP +S++QFV VR +S GP ++HCSAGVGRTGTFIALDR+L
Sbjct: 257 NYTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDRLL 314
Query: 2140 QQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIY 2199
Q + + VDI G V ++R +R+ MVQTE QY+++HQCV+ + +K +Q IY
Sbjct: 315 QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK---QQFCISDVIY 371
Query: 2200 ENVN 2203
ENV+
Sbjct: 372 ENVS 375
>gi|13677222 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 297 bits (760), Expect = 9e-80
Identities = 154/329 (46%), Positives = 217/329 (65%), Gaps = 13/329 (3%)
Query: 1880 DRPLSVHLNLGQKGN---RKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQS 1936
D L+ ++N K RK + P++++ F+ + + DS+Y S ++EELK +G +
Sbjct: 83 DYLLAFYINPWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIP 142
Query: 1937 CDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGP 1996
A LP NR KNRY NILPYD +RV+L +++++ +DYINA+YIPG N +EYI TQGP
Sbjct: 143 HFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGP 202
Query: 1997 LPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVL 2056
LP T++DFWKMV +Q IVM+TQC EK RVKCDHYWP ++ + YGD+ ++M+SE
Sbjct: 203 LPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQ 262
Query: 2057 PEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPG 2114
+W R F+I D + + HF+YT WPDHGVP +S++QFV VR +S
Sbjct: 263 DDWACRHFRI---NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKS-- 317
Query: 2115 AGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYL 2174
GP ++HCSAGVGRTGTFIALDR+LQ + + VDI G V ++R +R+ MVQTE QY+++
Sbjct: 318 KGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFI 377
Query: 2175 HQCVRDVLRARKLRSEQENPLFPIYENVN 2203
HQCV+ + +K +Q IYENV+
Sbjct: 378 HQCVQLMWMKKK---QQFCISDVIYENVS 403
>gi|13677218 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 297 bits (760), Expect = 9e-80
Identities = 154/329 (46%), Positives = 217/329 (65%), Gaps = 13/329 (3%)
Query: 1880 DRPLSVHLNLGQKGN---RKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQS 1936
D L+ ++N K RK + P++++ F+ + + DS+Y S ++EELK +G +
Sbjct: 83 DYLLAFYINPWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIP 142
Query: 1937 CDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGP 1996
A LP NR KNRY NILPYD +RV+L +++++ +DYINA+YIPG N +EYI TQGP
Sbjct: 143 HFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGP 202
Query: 1997 LPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVL 2056
LP T++DFWKMV +Q IVM+TQC EK RVKCDHYWP ++ + YGD+ ++M+SE
Sbjct: 203 LPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQ 262
Query: 2057 PEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPG 2114
+W R F+I D + + HF+YT WPDHGVP +S++QFV VR +S
Sbjct: 263 DDWACRHFRI---NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKS-- 317
Query: 2115 AGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYL 2174
GP ++HCSAGVGRTGTFIALDR+LQ + + VDI G V ++R +R+ MVQTE QY+++
Sbjct: 318 KGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFI 377
Query: 2175 HQCVRDVLRARKLRSEQENPLFPIYENVN 2203
HQCV+ + +K +Q IYENV+
Sbjct: 378 HQCVQLMWMKKK---QQFCISDVIYENVS 403
>gi|13677214 receptor-type protein tyrosine phosphatase O isoform a
precursor [Homo sapiens]
Length = 1216
Score = 297 bits (760), Expect = 9e-80
Identities = 154/329 (46%), Positives = 217/329 (65%), Gaps = 13/329 (3%)
Query: 1880 DRPLSVHLNLGQKGN---RKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQS 1936
D L+ ++N K RK + P++++ F+ + + DS+Y S ++EELK +G +
Sbjct: 894 DYLLAFYINPWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIP 953
Query: 1937 CDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGP 1996
A LP NR KNRY NILPYD +RV+L +++++ +DYINA+YIPG N +EYI TQGP
Sbjct: 954 HFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGP 1013
Query: 1997 LPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVL 2056
LP T++DFWKMV +Q IVM+TQC EK RVKCDHYWP ++ + YGD+ ++M+SE
Sbjct: 1014 LPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQ 1073
Query: 2057 PEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPG 2114
+W R F+I D + + HF+YT WPDHGVP +S++QFV VR +S
Sbjct: 1074 DDWACRHFRI---NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKS-- 1128
Query: 2115 AGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYL 2174
GP ++HCSAGVGRTGTFIALDR+LQ + + VDI G V ++R +R+ MVQTE QY+++
Sbjct: 1129 KGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFI 1188
Query: 2175 HQCVRDVLRARKLRSEQENPLFPIYENVN 2203
HQCV+ + +K +Q IYENV+
Sbjct: 1189 HQCVQLMWMKKK---QQFCISDVIYENVS 1214
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 296 bits (758), Expect = 2e-79
Identities = 388/1552 (25%), Positives = 656/1552 (42%), Gaps = 191/1552 (12%)
Query: 770 TVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFH 829
+ P +T ++++ G F + G ++ Y + L N + +I++ + +
Sbjct: 761 SAPENITYKNISS-GEIELSFLPPSSPNGIIQKYTIYLKRSNGN-EERTINTTSLTQNIK 818
Query: 830 SLKSGSLYSVVVT--TVSG-GISSRQV-VVEGRTVPSS---------VSGVTVNNSGRND 876
LK + Y + V+ T+ G G+ S + ++ P S +SGVTV
Sbjct: 819 VLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVK------ 872
Query: 877 YLSVSWL--LAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRS 934
+SW L P + Y + ++++ + ++ E S VT +TR
Sbjct: 873 ---LSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRF 929
Query: 935 GKYENHS----FSQERTVP-DKVQGVSVSNSARSDYLRVSWVHAT---GDFDHYEVTIKN 986
G + S F P D + V +N + S + + W + G +Y V +N
Sbjct: 930 GDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSII-LFWTPPSKPNGIIQYYSVYYRN 988
Query: 987 KNN-FIQTKSIPKSENE-------CVFVQLVPGRLYSVTVTTKSGQYEANEQGN------ 1032
+ F+Q ++ + N+ + +L Y+ +T + N+ +
Sbjct: 989 TSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYT 1048
Query: 1033 GRTIPEP-VKDLTLRNRSTEDLHVTW---SGANGDVDQYEIQLLFNDMK-VFPPFHLVNT 1087
+ IPE V +LT + S+ ++V+W + NG V Y +L + V PP LV
Sbjct: 1049 DQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPP--LVTY 1106
Query: 1088 ATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFT----------VPSAVKNIHISPNG 1137
F +L Y IL +T S + F + +T VP I+ N
Sbjct: 1107 ERSIYFDNLEKYTDY-ILKITPS---TEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNL 1162
Query: 1138 ATDSLTVNWTPG---GGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMI 1194
++ S+ ++W P G + SY ++ ++ T ++ L Y
Sbjct: 1163 SSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYII---LEELSPFTLYSFFA 1219
Query: 1195 ASVSGSLKNQINVV----GRTVP-ASVQGVIADNAYSSYSLIVSWQKA---AGVAERYDI 1246
A+ + +++ +VP A Q + N S + + + W + G+ + Y
Sbjct: 1220 AARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDF-VWLKWSPSPLPGGIVKVYSF 1278
Query: 1247 LLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVS----GGLFSKEAQ-TEGRT 1301
+ + + + K L P Y I++ + G FS + T +
Sbjct: 1279 KIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQES 1338
Query: 1302 VPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQN 1361
VP V +++ S + + +W + ++ + N +V P ++F
Sbjct: 1339 VPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERN---STKVSPQDHMYTFIK 1395
Query: 1362 LLQGRMY--KMVIVTHSGELSNESFIFGRTVPASV----SHLRGSNRNTTDSL--WFNWS 1413
LL Y K+ T +GE +ES T+P +V +++ S+ +T + W
Sbjct: 1396 LLANTSYVFKVRASTSAGE-GDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPD 1454
Query: 1414 PASGDFDFYELILYNPNGTKKENWKDKD--------------LTEWRFQGLVPGRKYVLW 1459
G F Y+ I K + W+ ++ LTE GL R Y
Sbjct: 1455 TILGYFQNYK-ITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQ 1513
Query: 1460 VVTHS----GDLSNKVTAESRTAP--SPPSLMSFADIANTSLAITWKGPPDWTDYNDF-- 1511
V + G+ SN ++ ++ P PP + + S++I+W P T +
Sbjct: 1514 VAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEPAVITGPTCYLI 1573
Query: 1512 ELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGD------SWKTYSKPI 1565
+++ + D + +N +++ + L Y + +G+ K+ ++ I
Sbjct: 1574 DVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMI 1633
Query: 1566 FGSVRTKP-DKIQNLHCR--PQNSTAIACSWIPP---DSDFDGY-SIECRKMDTQEVEFS 1618
++ + P D N+ + P T +++PP + + Y ++ R+ D V+
Sbjct: 1634 VTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIH 1693
Query: 1619 RK--LEKEKSLLNIMM--LVPHKRYLVSI-KVQSAGMTSEVVEDST--ITMIDRPPPPPP 1671
++K + + M+ L Y +S+ V SAG +V T I RP P
Sbjct: 1694 NLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPMRITMDIKAPARPKTKPT 1753
Query: 1672 HIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYL 1731
I +L++ ++I + ++SD +G +K V+V E + + Y
Sbjct: 1754 PIYDATGKLLVTSTTITIRMPICYYSDDHGPIKNVQVLVTETGAQHDGNVTKW-----YD 1808
Query: 1732 EYRHNASIRVYQTN--YFASKCAENPNSNSKSFNIKL-GAEMESLGGKCDPTQQKFCDGP 1788
Y + A R Y TN + C E S + I + GA+ + + K C+GP
Sbjct: 1809 AYFNKA--RPYFTNEGFPNPPCTEGKTKFSGNEEIYIIGADNACM---IPGNEDKICNGP 1863
Query: 1789 LKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGV--SAGLF 1846
LKP Y RA + +FT YSD P+ T E L + S L
Sbjct: 1864 LKPKKQYLFKFRA-----TNIMGQFTDSDYSD-----PVKTLGEGLSERTVEIILSVTLC 1913
Query: 1847 LIGMLV---AVVALLICRQKVSHG-----RERPSARLSIRRDRPLSV-HLNLGQK----- 1892
++ +++ A+ A RQK G ++ ++ D+ ++V L L +
Sbjct: 1914 ILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTRL 1973
Query: 1893 -GNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRY 1951
RK+ PI F H +L ++N +E+ EL ++ S A LP NR KNR+
Sbjct: 1974 LSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRF 2033
Query: 1952 NNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQ 2011
NI PY+ RVKL P SDYINASYI G E+I TQGPLPGT DFW+MVWE
Sbjct: 2034 PNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWET 2093
Query: 2012 NVHNIVMVTQCVEKGRVKCDHYWPADQDSL-YYGDLILQMLSESVLPEWTIREFKICGEE 2070
+VM+TQC EKGR++C YWP D + +GD+++ L E V +WTIR+ KI E
Sbjct: 2094 RAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI---E 2150
Query: 2071 QLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTG 2130
+ +R ++T WP+HGVPE + LI FV+ VR +R+ P +VHCSAGVGRTG
Sbjct: 2151 RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVR--ASRAHDTTPMIVHCSAGVGRTG 2208
Query: 2131 TFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL 2182
FIALD + Q ++ D VDIYG V +LR R+ MVQ QY++LHQC+ D+L
Sbjct: 2209 VFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL 2260
Score = 53.5 bits (127), Expect = 2e-06
Identities = 197/1029 (19%), Positives = 377/1029 (36%), Gaps = 158/1029 (15%)
Query: 559 TETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVA------------------- 599
T+ +VPG Y +T+S +S ++ + T K
Sbjct: 17 TQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGILLSW 76
Query: 600 NLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPG 659
N N NGR+ S +V + W Q V + + + ++ T L PG
Sbjct: 77 NTPPNPNGRIISYIVKYKEVC-PWMQ---------TVYTQVRSKPDSLEVLL--TNLNPG 124
Query: 660 RQYEVEVIVES----GNLKNSERCQ-GRTVPLAVLQLRVKHANETSLSIMW---QTPVAE 711
YE++V E+ G + Q + P V+ L V+ N +++ ++W + P +
Sbjct: 125 TTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGK 184
Query: 712 WEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTV 771
+ IS+ ++ K +S D++ G+ +NS S T
Sbjct: 185 ITSFKISVKHARSGIVVKDVS-----IRVEDILTGKLPECN--------ENSESFLWSTA 231
Query: 772 PAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSL 831
T V T+ + TQ +E + E IS + ++
Sbjct: 232 SPSPTLGRVTPPSRTTHSSSTLTQ-------------NEISSVWKEPISFVVTHLRPYTT 278
Query: 832 KSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSV--SGVTVNNSGRNDYLSVSW---LLAP 886
L+ V T G +V +VP + VT N +G++ S+ W +
Sbjct: 279 Y---LFEVSAATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKS--FSILWDPPTIVT 333
Query: 887 GDVDNYEVTL-SHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRS----GKYENHS 941
G +Y V L G+++ + + + +F++LTP +Y V I + G N S
Sbjct: 334 GKF-SYRVELYGPSGRILDN---STKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNIS 389
Query: 942 FSQERTVPDKVQGVSVSNSARSDYLRVSWV---HATGDFDHYEVTIK-NKNNFIQTKSIP 997
VP V + ++ S +R++W G + Y V + + I ++
Sbjct: 390 VFTPPDVPGAVFDLQLAE-VESTQVRITWKKPRQPNGIINQYRVKVLVPETGIILENTLL 448
Query: 998 KSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIP--------EPVKDLTLRNRS 1049
NE + + P + ++ V G YE + + + P K+ RNR+
Sbjct: 449 TGNNEYINDPMAP-EIVNI-VEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRA 506
Query: 1050 TEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPF--HLVNTATEYRFTSLTPGRQYKILVL 1107
+ + N + + L ++ PF H+++ + FT + G + V
Sbjct: 507 EDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSA---FTIMGEGPPTVLSVR 563
Query: 1108 TISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPG---GGDVDSYTVSAFRHS 1164
T VPS++K I+ N ++ S+ + W P G + YT+ A
Sbjct: 564 TRQ------------QVPSSIKIINYK-NISSSSILLYWDPPEYPNGKITHYTIYAMELD 610
Query: 1165 QK-------VDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINV-VGRTVPASV 1216
+D+ + + ++T +++ + +S+S +N I V P S
Sbjct: 611 TNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSE--ENDIFVRTSEDEPESS 668
Query: 1217 QGVIADNAYSSYSLIVSW---QKAAGVAERYDILLLTENGILLRNTSEPATTKQHKFEDL 1273
+ ++ + + W +K G+ Y++L + + ++NTS T +L
Sbjct: 669 PQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTS----TTDIILRNL 724
Query: 1274 TPGKKYKIQILT---------VSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWT 1324
P Y I + + VS L + ++T + P +T I+ +
Sbjct: 725 RPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPS 784
Query: 1325 ASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGELSNE-- 1382
+ G + Y I+L +GN + L Q+ + ++ T GE
Sbjct: 785 SPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAP 844
Query: 1383 -SFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPA---SGDFDFYELILYNPNGTKKENWK 1438
S + P S + + ++ +W P +G +Y + ++N + K N
Sbjct: 845 ISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVT 904
Query: 1439 DKDLTEWRFQGLVPGRKYVLWVVTHSGD---LSNKVTAES-RTAPS-PPSLMSFADIANT 1493
+ L V YV T GD SN ++ ++ APS PP + +A+++++
Sbjct: 905 ETSLELSDLDYNVEYSAYVT-ASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSS 963
Query: 1494 SLAITWKGP 1502
S+ + W P
Sbjct: 964 SIILFWTPP 972
Score = 45.4 bits (106), Expect = 6e-04
Identities = 35/167 (20%), Positives = 70/167 (41%), Gaps = 18/167 (10%)
Query: 1443 TEWRFQGLVPGRKYVLWVVTHSGDLSNKVT---AESRTAPSPPSLMSFADIANTSLAITW 1499
T+ +VPG +Y + + + S ++ VT + T P PP ++ + + + ++W
Sbjct: 17 TQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGILLSW 76
Query: 1500 KGPPD--------WTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVY-GLRPGRSYQFNV 1550
PP+ Y + W+ TV+ ++ ++ L PG +Y+ V
Sbjct: 77 NTPPNPNGRIISYIVKYKEV-CPWMQ----TVYTQVRSKPDSLEVLLTNLNPGTTYEIKV 131
Query: 1551 KTVSGDSWKTYSKP-IFGSVRTKPDKIQNLHCRPQNSTAIACSWIPP 1596
+ +S P +F + + P K+ NL N++A+ W P
Sbjct: 132 AAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLP 178
Score = 38.9 bits (89), Expect = 0.057
Identities = 52/257 (20%), Positives = 112/257 (43%), Gaps = 37/257 (14%)
Query: 1479 PSPPSLMSFADIANTSLAITWKGPPDW-----TDYNDFELQWLPRDALTVFNPYNNRKSE 1533
PS ++++ +I+++S+ + W PP++ T Y + ++ A + N+
Sbjct: 569 PSSIKIINYKNISSSSILLYWD-PPEYPNGKITHYTIYAMELDTNRAFQITTIDNSF--- 624
Query: 1534 GRIVYGLRPGRSYQFNV--KTVSGDSWKTYSKPIFGSVRTKPDKI----QNLHCRPQNST 1587
++ GL+ Y+ V T G+S + IF VRT D+ Q++ +
Sbjct: 625 --LITGLKKYTKYKMRVAASTHVGESSLSEENDIF--VRTSEDEPESSPQDVEVIDVTAD 680
Query: 1588 AIACSWIPPDSD---FDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMM--LVPHKRYLVS 1642
I W PP+ Y + + +DT + K S +I++ L PH Y +S
Sbjct: 681 EIRLKWSPPEKPNGIIIAYEVLYKNIDTLYM-------KNTSTTDIILRNLRPHTLYNIS 733
Query: 1643 IKVQSA-GMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNG 1701
++ + G ++V ++ + P P + K++ + ++F S NG
Sbjct: 734 VRSYTRFGHGNQVSSLLSVRTSETVPDSAPE-NITYKNISSGEIELSFLPP----SSPNG 788
Query: 1702 AVKYFTVVVREADGSDE 1718
++ +T+ ++ ++G++E
Sbjct: 789 IIQKYTIYLKRSNGNEE 805
Score = 31.6 bits (70), Expect = 9.0
Identities = 56/234 (23%), Positives = 95/234 (40%), Gaps = 40/234 (17%)
Query: 230 FSSTTEETGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYS-------SDTLG 282
F T E LA P+ N TL +S V ++W P +YS +DT+
Sbjct: 1234 FFYTDESVPLAPPQ--NLTLIN--CTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIY 1289
Query: 283 AALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISL------DEERTVVLQT--DPLPPARF 334
F+ + G L+ + Y+ R+ + ++ VV T + +P
Sbjct: 1290 YKNISGFKTEAKLVG-----LEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQ 1344
Query: 335 GVSKEKTTSTSLHVWWTP---SSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNL 391
+ T+ S+ V W P ++G +T Y V + + N+ K+ S + YTF L
Sbjct: 1345 NMQCMATSWQSVLVKWDPPKKANGIITQYMVTV-ERNSTKV-------SPQDHMYTFIKL 1396
Query: 392 TAGSKY----NIAITAVSGGKRSFSVYTNGSTVPSPVKDIGIS-TKANSLLISW 440
A + Y + +A G + + V T TVPS +I S ++ S ++W
Sbjct: 1397 LANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTW 1450
>gi|241896926 protein tyrosine phosphatase, receptor type, H isoform 2
precursor [Homo sapiens]
Length = 937
Score = 280 bits (717), Expect = 9e-75
Identities = 152/372 (40%), Positives = 217/372 (58%), Gaps = 24/372 (6%)
Query: 1836 GAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNR 1895
G I G G+ L +LV ++ + R+ +++P R L G+
Sbjct: 575 GVIAGAFVGILLFLILVGLLIFFLKRRNKKK-QQKPELR-----------DLVFSSPGD- 621
Query: 1896 KTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNIL 1955
I F H K + DSN + +Y++L VG +QS +A EN KNRY N+L
Sbjct: 622 -----IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVL 676
Query: 1956 PYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN 2015
PYD +RV L + ++P SDYINAS++PG +E+I TQGPLP T DFW++VWEQ H
Sbjct: 677 PYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHT 736
Query: 2016 IVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH 2075
+VM+T C+E GRVKC+HYWP D +G L + ++ E V+ WT+RE + E+
Sbjct: 737 LVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEE-QKT 795
Query: 2076 RLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIAL 2135
+R FHY WPDHGVP + +L+ F R +R +++++ GP +VHCSAGVGRTGT IAL
Sbjct: 796 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 855
Query: 2136 DRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV-RDVLRARKLRSEQENP 2194
D +L+QL S+ + + V +R R MVQTE QYV+LHQC+ R + ++ + +E+E P
Sbjct: 856 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVP 915
Query: 2195 LFP----IYENV 2202
IYENV
Sbjct: 916 YEDVENLIYENV 927
Score = 77.0 bits (188), Expect = 2e-13
Identities = 105/468 (22%), Positives = 185/468 (39%), Gaps = 45/468 (9%)
Query: 321 TVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSYEVQLFDENNQKIQGVQI 377
TV T P P V E T++S+ + W G + ++Y V+ + G
Sbjct: 112 TVTTATAPNPVRNLTV--EAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG-----GRAG 164
Query: 378 QESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKAN-SL 436
ST+ T L G Y ++ G S N +T P+PV+++ + T+ N S+
Sbjct: 165 TRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSI 224
Query: 437 LISWSHGSGNVER---YRLMLMDKGILVHGGVVDKHA--TSYAFHGLTPGYLYNLTVMTE 491
+ W G + Y + G GG ++ TS L PG LY +V E
Sbjct: 225 ALCWEVPDGPYPQDYTYWVEYTGDG----GGTETRNTTNTSVTAERLEPGTLYTFSVWAE 280
Query: 492 AAGLQNYRWKL-VRTAPMEVSNLKVTNDGSLTSLKVKWQRPPG-NVDSYNITLSH-KGTI 548
G + R + + T P V++L D + +++ ++W P G SY+ +S + +
Sbjct: 281 KNGARGSRQNVSISTVPNAVTSLS-KQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGM 339
Query: 549 KESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAV-GRTFPDKVANLEANNNG 607
+ R + T+ KEL G LY +TV E+ + T P++V +L+ N
Sbjct: 340 TDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQ-NETQ 398
Query: 608 RMRSLVVSWSPPAGDWEQYRILLF------------NDSVVLLNITVGKEETQYVMDDTG 655
S+++ W P Q + + +N T ET Y ++
Sbjct: 399 TKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVE--A 456
Query: 656 LVPGRQYEVEVIVESGNLKNSER--CQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWE 713
L PG Y V E ++ +S + C + V + ++++W P +E
Sbjct: 457 LEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYE 516
Query: 714 KYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLK 761
+ + + + + S + + L P R Y AT+T+I +K
Sbjct: 517 AFELEVGGQ---RGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMK 561
Score = 69.7 bits (169), Expect = 3e-11
Identities = 125/555 (22%), Positives = 202/555 (36%), Gaps = 66/555 (11%)
Query: 1037 PEPVKDLTLRNRSTEDLHVTWS---GANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRF 1093
P P ++LT+ ++T + ++W G + Y +Q + TAT
Sbjct: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRN---TTATNVTV 86
Query: 1094 TSLTPGRQYKILVLTISGDVQQSA-FIEGFTVPSAVKNIHISPNGATDSLTVNW-TPGGG 1151
L PG Y V V S + T P+ V+N+ + S+ + W P G
Sbjct: 87 DGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQ-TNSSIALTWEVPDGP 145
Query: 1152 DVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMI-ASVSGSLKNQINVVGR 1210
D + T + T T RLE G Y + +G ++
Sbjct: 146 DPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNAT 205
Query: 1211 TVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTE-----NGILLRNTSEPATT 1265
T P V+ + + +S S+ + W+ G + D E G RNT+ + T
Sbjct: 206 TAPNPVRNLHMETQTNS-SIALCWEVPDGPYPQ-DYTYWVEYTGDGGGTETRNTTNTSVT 263
Query: 1266 KQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTA 1325
E L PG Y + G TVP AVT L + + ++ RWTA
Sbjct: 264 A----ERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTA 319
Query: 1326 SEGE-LSWYNIFLYNPDGNLQERAQVDPLVQSFS-----FQNLLQGRMYKMVIVTHSGEL 1379
+G S Y+ ++ + DP QS S + L G +Y + + E+
Sbjct: 320 PQGPGQSSYSYWV-----SWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEV 374
Query: 1380 SN-ESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKK---- 1434
S + T P V+ L+ N T + W A GD +L +Y K
Sbjct: 375 RGYNSTLTAATAPNEVTDLQ--NETQTKNSVMLWWKAPGD-PHSQLYVYWVQWASKGHPR 431
Query: 1435 ------ENWKDK----DLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSL 1484
NW ++ + T ++ + L PG Y V D+++ + +S A + P
Sbjct: 432 RGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVAS--STQSLCASTYPDT 489
Query: 1485 MSFADIANTS----LAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI--VY 1538
++ +TS + + W P Y FEL+ + +R S G V
Sbjct: 490 VTITSCVSTSAGYGVNLIWSCPQG--GYEAFELE------VGGQRGSQDRSSCGEAVSVL 541
Query: 1539 GLRPGRSYQFNVKTV 1553
GL P RSY + T+
Sbjct: 542 GLGPARSYPATITTI 556
Score = 58.5 bits (140), Expect = 7e-08
Identities = 110/545 (20%), Positives = 205/545 (37%), Gaps = 36/545 (6%)
Query: 328 PLPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSYEVQLFDENNQKIQGVQIQESTSWN 384
P P ++ E T++S+ + W G + ++Y VQ + G +T+
Sbjct: 28 PAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDG-----GTTETRNTTAT 82
Query: 385 EYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKAN-SLLISWSHG 443
T L GS Y ++ G S +T P+PV+++ + + N S+ ++W
Sbjct: 83 NVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVP 142
Query: 444 SG-NVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYR-WK 501
G + + + G G T+ L PG LY +V G+ + R +
Sbjct: 143 DGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETR 202
Query: 502 LVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNV-DSYNITLSHKGTIKESRVLAPWITE 560
TAP V NL + + +S+ + W+ P G Y + + G + T
Sbjct: 203 NATTAPNPVRNLHMETQTN-SSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTS 261
Query: 561 THFKELVPGRLYQVTVSCVSGELSAQKMAVG-RTFPDKVANLEANNNGRMRSLVVSWSPP 619
+ L PG LY +V + V T P+ V +L + + ++ + W+ P
Sbjct: 262 VTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSL-SKQDWTNSTIALRWTAP 320
Query: 620 AGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDT--GLVPGRQYEVEVIVESGNLKN-S 676
G + + S V +T + ++ D T L G Y + V E ++ +
Sbjct: 321 QGPGQS--SYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYN 378
Query: 677 ERCQGRTVPLAVLQLRVKHANETSLSIMWQT---PVAEWEKYIISLA---------DRDL 724
T P V L+ + + S+ + W+ P ++ Y + A D
Sbjct: 379 STLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQA 438
Query: 725 LLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSS-SVKGRTVPAQVTDLHVANQ 783
++++ + + L PG Y TV + D+ +S+ S+ T P VT +
Sbjct: 439 NWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVST 498
Query: 784 GMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTT 843
+ W+ QG E +++ + + ++ SS S L Y +TT
Sbjct: 499 SAGYGVNLIWSCPQGGYEAFELEVGGQR---GSQDRSSCGEAVSVLGLGPARSYPATITT 555
Query: 844 VSGGI 848
+ G+
Sbjct: 556 IWDGM 560
Score = 57.4 bits (137), Expect = 2e-07
Identities = 116/546 (21%), Positives = 194/546 (35%), Gaps = 63/546 (11%)
Query: 871 NSGRN--------DYLSVSWLLAPG---DVDNYEVTLSHDGKVVQSLVIAKSVRECSFSS 919
N GRN +S+SW + G NY V + DG ++ + +
Sbjct: 31 NPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETR--NTTATNVTVDG 88
Query: 920 LTPGRLYTVTI-TTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFD 978
L PG LYT ++ + G + T P+ V+ ++V S + ++W G
Sbjct: 89 LGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSS-IALTWEVPDGPDP 147
Query: 979 H---YEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTT-KSGQYEANEQGNGR 1034
Y V T+S + +L PG LY +V K+G + E N
Sbjct: 148 QNSTYGVEYTGDGGRAGTRST--AHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNAT 205
Query: 1035 TIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFT 1094
T P PV++L + ++ + + W +G Q D + + TE R T
Sbjct: 206 TAPNPVRNLHMETQTNSSIALCWEVPDGPYPQ--------DYTYWVEYTGDGGGTETRNT 257
Query: 1095 S--------LTPGRQYKILVLTISGDVQQS-AFIEGFTVPSAVKNIHISPNGATDSLTVN 1145
+ L PG Y V + S + TVP+AV ++ + ++ +
Sbjct: 258 TNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLS-KQDWTNSTIALR 316
Query: 1146 WT-PGGGDVDSYT--VSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLK 1202
WT P G SY+ VS R D +T + T LEAG Y + + + ++
Sbjct: 317 WTAPQGPGQSSYSYWVSWVREGM-TDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVR 375
Query: 1203 N-QINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTE---NGILLR- 1257
+ T P V + N + + ++ W KA G + + G R
Sbjct: 376 GYNSTLTAATAPNEVTDL--QNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRG 433
Query: 1258 --------NTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDL 1309
N + +K E L PG Y + + S T P VT
Sbjct: 434 QDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTIT 493
Query: 1310 RITENSTRH-LSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMY 1368
S + ++ W+ +G + + + G+ Q+R+ ++ S L R Y
Sbjct: 494 SCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGS-QDRSSCG---EAVSVLGLGPARSY 549
Query: 1369 KMVIVT 1374
I T
Sbjct: 550 PATITT 555
Score = 55.8 bits (133), Expect = 4e-07
Identities = 73/347 (21%), Positives = 132/347 (38%), Gaps = 32/347 (9%)
Query: 255 SSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRII 314
++ S+++ W + P Y + G R + T + L+ GT+Y F +
Sbjct: 220 TNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETR-NTTNTSVTAERLEPGTLYTFSVW 278
Query: 315 S-----LDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSYEVQLFD 366
+ + V + T +P A +SK+ T++++ + WT G SY V
Sbjct: 279 AEKNGARGSRQNVSIST--VPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVR 336
Query: 367 ENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKD 426
E + +STS + T L AGS Y++ + A R ++ +T P+ V D
Sbjct: 337 EGMTDPR----TQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTD 392
Query: 427 IGISTKANSLLISWSHGSGNVER----YRLMLMDKGILVHG---------GVVDKHATSY 473
+ T+ + ++ W G+ Y + KG G + T Y
Sbjct: 393 LQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWY 452
Query: 474 AFHGLTPGYLYNLTVMTEAAGLQNYRWKL-VRTAPMEVSNLKVTNDGSLTSLKVKWQRPP 532
L PG LYN TV E + + L T P V+ + + + + W P
Sbjct: 453 KVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQ 512
Query: 533 GNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCV 579
G +++ + + G + S+ + L P R Y T++ +
Sbjct: 513 GGYEAFELEV---GGQRGSQDRSSCGEAVSVLGLGPARSYPATITTI 556
Score = 54.7 bits (130), Expect = 1e-06
Identities = 97/527 (18%), Positives = 198/527 (37%), Gaps = 41/527 (7%)
Query: 784 GMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTT 843
G+ S W Q GD E+ ++ + + L GSLY+ V
Sbjct: 55 GLDSQNSNYWVQCTGDGG-------------TTETRNTTATNVTVDGLGPGSLYTCSVWV 101
Query: 844 VSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPG-DVDNYEVTLSHDGKV 902
G++S V T P+ V +TV + N ++++W + G D N + + G
Sbjct: 102 EKDGVNSSVGTVTTATAPNPVRNLTV-EAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG 160
Query: 903 VQSLVIAKSVRECSFSSLTPGRLYTVTI-TTRSGKYENHSFSQERTVPDKVQGVSVSNSA 961
++ + + + L PG LY ++ ++G + T P+ V+ + +
Sbjct: 161 GRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQT 220
Query: 962 RSDYLRVSWVHATGDF-DHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTV-T 1019
S + + W G + Y ++ + T++ + +L PG LY+ +V
Sbjct: 221 NSS-IALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWA 279
Query: 1020 TKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANG-DVDQYEIQLLFNDMKV 1078
K+G + + + T+P V L+ ++ + + + W+ G Y + + +
Sbjct: 280 EKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGM 339
Query: 1079 FPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQ-QSAFIEGFTVPSAVKNIHISPNG 1137
P + T+ L G Y + V +V+ ++ + T P+ V ++
Sbjct: 340 TDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQ- 398
Query: 1138 ATDSLTVNWTPGGGDVDS----YTV--SAFRHSQKVD-------SQTIPKHVFEHTFHRL 1184
T + + W GD S Y V ++ H ++ +QT + + L
Sbjct: 399 -TKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEAL 457
Query: 1185 EAGEQYQIMI-ASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAER 1243
E G Y + A + + ++ T P +V + + Y + + W G E
Sbjct: 458 EPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEA 517
Query: 1244 YDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGL 1290
+++ + + G R++ A + L P + Y I T+ G+
Sbjct: 518 FELEVGGQRGSQDRSSCGEAVS----VLGLGPARSYPATITTIWDGM 560
Score = 45.1 bits (105), Expect = 8e-04
Identities = 52/208 (25%), Positives = 84/208 (40%), Gaps = 25/208 (12%)
Query: 1404 TTDSLWFNWSPASG----DFDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLW 1459
TT S+ +W G + +++ + T+ N ++T GL PG Y
Sbjct: 42 TTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVT---VDGLGPGSLYTCS 98
Query: 1460 VVTHSGDLSNKV-TAESRTAPSPPSLMSFADIANTSLAITWK---GPPDWTDYNDFELQW 1515
V +++ V T + TAP+P ++ N+S+A+TW+ GP E
Sbjct: 99 VWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTG 158
Query: 1516 LPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNV---KTVSGDSWKTYSKPIFGSVRTK 1572
A T + N V L PG Y F+V K S +T + T
Sbjct: 159 DGGRAGTRSTAHTNIT-----VDRLEPGCLYVFSVWVGKNGINSSRETRN------ATTA 207
Query: 1573 PDKIQNLHCRPQNSTAIACSWIPPDSDF 1600
P+ ++NLH Q +++IA W PD +
Sbjct: 208 PNPVRNLHMETQTNSSIALCWEVPDGPY 235
>gi|241896924 protein tyrosine phosphatase, receptor type, H isoform 1
precursor [Homo sapiens]
Length = 1115
Score = 280 bits (717), Expect = 9e-75
Identities = 152/372 (40%), Positives = 217/372 (58%), Gaps = 24/372 (6%)
Query: 1836 GAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNR 1895
G I G G+ L +LV ++ + R+ +++P R L G+
Sbjct: 753 GVIAGAFVGILLFLILVGLLIFFLKRRNKKK-QQKPELR-----------DLVFSSPGD- 799
Query: 1896 KTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNIL 1955
I F H K + DSN + +Y++L VG +QS +A EN KNRY N+L
Sbjct: 800 -----IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVL 854
Query: 1956 PYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN 2015
PYD +RV L + ++P SDYINAS++PG +E+I TQGPLP T DFW++VWEQ H
Sbjct: 855 PYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHT 914
Query: 2016 IVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH 2075
+VM+T C+E GRVKC+HYWP D +G L + ++ E V+ WT+RE + E+
Sbjct: 915 LVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEE-QKT 973
Query: 2076 RLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIAL 2135
+R FHY WPDHGVP + +L+ F R +R +++++ GP +VHCSAGVGRTGT IAL
Sbjct: 974 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 1033
Query: 2136 DRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV-RDVLRARKLRSEQENP 2194
D +L+QL S+ + + V +R R MVQTE QYV+LHQC+ R + ++ + +E+E P
Sbjct: 1034 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVP 1093
Query: 2195 LFP----IYENV 2202
IYENV
Sbjct: 1094 YEDVENLIYENV 1105
Score = 99.0 bits (245), Expect = 5e-20
Identities = 169/741 (22%), Positives = 282/741 (38%), Gaps = 83/741 (11%)
Query: 328 PLPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSYEVQLFDENNQKIQGVQIQESTSWN 384
P P ++ E T++S+ + W G + ++Y VQ + G +T+
Sbjct: 28 PAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDG-----GTTETRNTTAT 82
Query: 385 EYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKAN-SLLISWSHG 443
T L GS Y ++ G S +T P+PV+++ + + N S+ ++W
Sbjct: 83 NVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVP 142
Query: 444 SG-NVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYR-WK 501
G + + + G G T+ GL PG LY ++ G+ + R +
Sbjct: 143 DGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETR 202
Query: 502 LVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITET 561
TA V NL+V + +S+ + W+ P G D N T + T R T+T
Sbjct: 203 NATTAHNPVRNLRVEAQ-TTSSISLSWEVPDG-TDPQNSTYCVQCTGDGGRTETRNTTDT 260
Query: 562 H--FKELVPGRLYQVTVSC-VSGELSAQKMAVGRTFPDKVANL--EANNNGRMRSLVVSW 616
L PG LY +V G S+ ++ T P+ V NL EA N S+ ++W
Sbjct: 261 RVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNS---SIALTW 317
Query: 617 SPPAGDWEQ---YRILLFND-------SVVLLNITVGKEETQYVMDDTGLVPGRQYEVEV 666
P G Q Y + D S NITV + L PG Y V
Sbjct: 318 EVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDR-----------LEPGCLYVFSV 366
Query: 667 IVESGNLKNS-ERCQGRTVPLAVLQLRVKHANETSLSIMWQTP-------VAEWEKYIIS 718
V + +S E T P V L ++ +S+++ W+ P W +Y
Sbjct: 367 WVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGD 426
Query: 719 LADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNS-SSVKGRTVPAQVTD 777
+ + + T L PG Y +V + + S +V TVP VT
Sbjct: 427 GGGTE------TRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTS 480
Query: 778 LHVANQGMT-SSLFTNWTQAQGDVE---FYQVLLIHENVVIKNESISSETSRYSFHSLKS 833
L + Q T S++ WT QG + Y V + E + +S T + L++
Sbjct: 481 L--SKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTD-ITLKELEA 537
Query: 834 GSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDN-- 891
GSLY + V + + T P+ V+ + +N + W APGD +
Sbjct: 538 GSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVM--LWWKAPGDPHSQL 595
Query: 892 --YEVTLS-----HDGKVVQSLVIAKSVRE----CSFSSLTPGRLYTVTITTRSGKYENH 940
Y V + G+ Q+ + ++ R +L PG LY T+ +
Sbjct: 596 YVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASS 655
Query: 941 SFSQ-ERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKS 999
+ S T PD V S +++ + + W G ++ +E+ + + S ++
Sbjct: 656 TQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEA 715
Query: 1000 ENECVFVQLVPGRLYSVTVTT 1020
+ + L P R Y T+TT
Sbjct: 716 VS---VLGLGPARSYPATITT 733
Score = 86.7 bits (213), Expect = 2e-16
Identities = 166/739 (22%), Positives = 270/739 (36%), Gaps = 91/739 (12%)
Query: 871 NSGRN--------DYLSVSWLLAPG---DVDNYEVTLSHDGKVVQSLVIAKSVRECSFSS 919
N GRN +S+SW + G NY V + DG ++ + +
Sbjct: 31 NPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETR--NTTATNVTVDG 88
Query: 920 LTPGRLYTVTI-TTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFD 978
L PG LYT ++ + G + T P+ V+ + V S + ++W G
Sbjct: 89 LGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSS-IALTWEVPDGPDP 147
Query: 979 H---YEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTT-KSGQYEANEQGNGR 1034
Y V T+S + L PG LY+ ++ K+G + E N
Sbjct: 148 QNSTYGVEYTGDGGRAGTRST--AHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNAT 205
Query: 1035 TIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQ---YEIQLLFNDMKVFPPFHLVNTATEY 1091
T PV++L + ++T + ++W +G Q Y +Q + + T+
Sbjct: 206 TAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTE-----TRNTTDT 260
Query: 1092 RFT--SLTPGRQYKILVLTISGDVQQSA-FIEGFTVPSAVKNIHISPNGATDSLTVNW-T 1147
R T L PG Y V V S + T P+ V+N+ + S+ + W
Sbjct: 261 RVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQ-TNSSIALTWEV 319
Query: 1148 PGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMI-ASVSGSLKNQIN 1206
P G D + T + T T RLE G Y + +G ++
Sbjct: 320 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRET 379
Query: 1207 VVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTE-----NGILLRNTSE 1261
T P V+ + + +S S+ + W+ G + D E G RNT+
Sbjct: 380 RNATTAPNPVRNLHMETQTNS-SIALCWEVPDGPYPQ-DYTYWVEYTGDGGGTETRNTTN 437
Query: 1262 PATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSF 1321
+ T E L PG Y + G TVP AVT L + + ++
Sbjct: 438 TSVTA----ERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIAL 493
Query: 1322 RWTASEGE-LSWYNIFLYNPDGNLQERAQVDPLVQSFS-----FQNLLQGRMYKMVIVTH 1375
RWTA +G S Y+ ++ + DP QS S + L G +Y + +
Sbjct: 494 RWTAPQGPGQSSYSYWV-----SWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAE 548
Query: 1376 SGELSN-ESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKK 1434
E+ S + T P V+ L+ N T + W A GD +L +Y K
Sbjct: 549 RNEVRGYNSTLTAATAPNEVTDLQ--NETQTKNSVMLWWKAPGD-PHSQLYVYWVQWASK 605
Query: 1435 ----------ENWKDK----DLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPS 1480
NW ++ + T ++ + L PG Y V D+++ + +S A +
Sbjct: 606 GHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVAS--STQSLCAST 663
Query: 1481 PPSLMSFADIANTS----LAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI 1536
P ++ +TS + + W P Y FEL+ + +R S G
Sbjct: 664 YPDTVTITSCVSTSAGYGVNLIWSCPQG--GYEAFELE------VGGQRGSQDRSSCGEA 715
Query: 1537 --VYGLRPGRSYQFNVKTV 1553
V GL P RSY + T+
Sbjct: 716 VSVLGLGPARSYPATITTI 734
Score = 74.7 bits (182), Expect = 9e-13
Identities = 104/467 (22%), Positives = 184/467 (39%), Gaps = 45/467 (9%)
Query: 322 VVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSYEVQLFDENNQKIQGVQIQ 378
V T P P V E T++S+ + W G + ++Y V+ + G
Sbjct: 291 VTSATAPNPVRNLTV--EAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG-----GRAGT 343
Query: 379 ESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKAN-SLL 437
ST+ T L G Y ++ G S N +T P+PV+++ + T+ N S+
Sbjct: 344 RSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIA 403
Query: 438 ISWSHGSGNVER---YRLMLMDKGILVHGGVVDKHA--TSYAFHGLTPGYLYNLTVMTEA 492
+ W G + Y + G GG ++ TS L PG LY +V E
Sbjct: 404 LCWEVPDGPYPQDYTYWVEYTGDG----GGTETRNTTNTSVTAERLEPGTLYTFSVWAEK 459
Query: 493 AGLQNYRWKL-VRTAPMEVSNLKVTNDGSLTSLKVKWQRPPG-NVDSYNITLSH-KGTIK 549
G + R + + T P V++L D + +++ ++W P G SY+ +S + +
Sbjct: 460 NGARGSRQNVSISTVPNAVTSLS-KQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMT 518
Query: 550 ESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAV-GRTFPDKVANLEANNNGR 608
+ R + T+ KEL G LY +TV E+ + T P++V +L+ N
Sbjct: 519 DPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQ-NETQT 577
Query: 609 MRSLVVSWSPPAGDWEQYRILLF------------NDSVVLLNITVGKEETQYVMDDTGL 656
S+++ W P Q + + +N T ET Y ++ L
Sbjct: 578 KNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVE--AL 635
Query: 657 VPGRQYEVEVIVESGNLKNSER--CQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEK 714
PG Y V E ++ +S + C + V + ++++W P +E
Sbjct: 636 EPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEA 695
Query: 715 YIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLK 761
+ + + + + S + + L P R Y AT+T+I +K
Sbjct: 696 FELEVGGQ---RGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMK 739
Score = 70.5 bits (171), Expect = 2e-11
Identities = 139/709 (19%), Positives = 268/709 (37%), Gaps = 44/709 (6%)
Query: 611 SLVVSWSPPAGDWEQ---YRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVI 667
S+ +SW P G Q Y + D T + T + GL PG Y V
Sbjct: 45 SISLSWEVPDGLDSQNSNYWVQCTGDG----GTTETRNTTATNVTVDGLGPGSLYTCSVW 100
Query: 668 VESGNLKNSE-RCQGRTVPLAVLQLRVKHANETSLSIMWQTPVA---EWEKYIISLADRD 723
VE + +S T P V LRV+ +S+++ W+ P + Y +
Sbjct: 101 VEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG 160
Query: 724 LLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQ-VTDLHVAN 782
+S + T L PG Y ++ + +S + T V +L V
Sbjct: 161 GRAGTRSTAHT--NITVDGLEPGCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEA 218
Query: 783 QGMTSSLFTNWTQAQG-DVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVV 841
Q TSS+ +W G D + + + E+ ++ +R + L GSLY+ V
Sbjct: 219 Q-TTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSV 277
Query: 842 TTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPG-DVDNYEVTLSHDG 900
G++S +V T P+ V +TV + N ++++W + G D N + + G
Sbjct: 278 WVEKDGVNSSVEIVTSATAPNPVRNLTV-EAQTNSSIALTWEVPDGPDPQNSTYGVEYTG 336
Query: 901 KVVQSLVIAKSVRECSFSSLTPGRLYTVTI-TTRSGKYENHSFSQERTVPDKVQGVSVSN 959
++ + + + L PG LY ++ ++G + T P+ V+ + +
Sbjct: 337 DGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMET 396
Query: 960 SARSDYLRVSWVHATGDF-DHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTV 1018
S + + W G + Y ++ + T++ + +L PG LY+ +V
Sbjct: 397 QTNSS-IALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSV 455
Query: 1019 -TTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANG-DVDQYEIQLLFNDM 1076
K+G + + + T+P V L+ ++ + + + W+ G Y + +
Sbjct: 456 WAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVRE 515
Query: 1077 KVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQ-QSAFIEGFTVPSAVKNIHISP 1135
+ P + T+ L G Y + V +V+ ++ + T P+ V ++
Sbjct: 516 GMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNET 575
Query: 1136 NGATDSLTVNWTPGGGDVDS----YTV--SAFRHSQKVD-------SQTIPKHVFEHTFH 1182
T + + W GD S Y V ++ H ++ +QT + +
Sbjct: 576 Q--TKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVE 633
Query: 1183 RLEAGEQYQIMI-ASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVA 1241
LE G Y + A + + ++ T P +V + + Y + + W G
Sbjct: 634 ALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGY 693
Query: 1242 ERYDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGL 1290
E +++ + + G R++ A + L P + Y I T+ G+
Sbjct: 694 EAFELEVGGQRGSQDRSSCGEAVS----VLGLGPARSYPATITTIWDGM 738
Score = 65.5 bits (158), Expect = 6e-10
Identities = 114/577 (19%), Positives = 204/577 (35%), Gaps = 35/577 (6%)
Query: 1037 PEPVKDLTLRNRSTEDLHVTW---SGANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRF 1093
P P ++LT+ ++T + ++W G + Y +Q + TAT
Sbjct: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTET---RNTTATNVTV 86
Query: 1094 TSLTPGRQYKILVLTISGDVQQS-AFIEGFTVPSAVKNIHISPNGATDSLTVNW-TPGGG 1151
L PG Y V V S + T P+ V+N+ + S+ + W P G
Sbjct: 87 DGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQ-TNSSIALTWEVPDGP 145
Query: 1152 DVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRT 1211
D + T + T T LE G Y + + + T
Sbjct: 146 DPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNAT 205
Query: 1212 VPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTSEPATTKQHKFE 1271
+ + A ++ S+ +SW+ G + + G R + T + +
Sbjct: 206 TAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVD 265
Query: 1272 DLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEG--- 1328
L PG Y + G+ S T P V +L + + ++ W +G
Sbjct: 266 GLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDP 325
Query: 1329 ELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKM-VIVTHSGELSNESFIFG 1387
+ S Y + G R+ + + L G +Y V V +G S+
Sbjct: 326 QNSTYGVEYTGDGGRAGTRSTAH---TNITVDRLEPGCLYVFSVWVGKNGINSSRETRNA 382
Query: 1388 RTVPASVSHLRGSNRNTTDSLWFNWSPASG----DFDFYELILYNPNGTKKENWKDKDLT 1443
T P V +L T S+ W G D+ ++ + GT+ N + +T
Sbjct: 383 TTAPNPVRNLH-METQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVT 441
Query: 1444 EWRFQGLVPGRKYVLWV-VTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSLAITWKGP 1502
R L PG Y V +G ++ T P+ + +S D N+++A+ W P
Sbjct: 442 AER---LEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAP 498
Query: 1503 --PDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI-VYGLRPGRSYQFNVKTVSGDSWK 1559
P + Y+ + + W+ R+ +T +P S I + L G Y V + +
Sbjct: 499 QGPGQSSYS-YWVSWV-REGMT--DPRTQSTSGTDITLKELEAGSLYHLTV-WAERNEVR 553
Query: 1560 TYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPP 1596
Y+ + + T P+++ +L Q ++ W P
Sbjct: 554 GYNSTL--TAATAPNEVTDLQNETQTKNSVMLWWKAP 588
Score = 61.2 bits (147), Expect = 1e-08
Identities = 133/653 (20%), Positives = 241/653 (36%), Gaps = 57/653 (8%)
Query: 231 SSTTEETGLAEPERCNFTLAESKASSHSVSIQWRILGSP----CNFSLIYSSDTLGAALC 286
SS T P E++ +S S+++ W + P + + Y+ D A
Sbjct: 108 SSVGTVTTATAPNPVRNLRVEAQTNS-SIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTR 166
Query: 287 PTFRIDNTTYGCNLQDLQAGTIYNFR-------IISLDEERTVVLQTDPLPPARFGVSKE 339
T + T G L+ G +Y F I S E R +P+ R E
Sbjct: 167 STAHTNITVDG-----LEPGCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRV----E 217
Query: 340 KTTSTSLHVWWTPSSG---KVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSK 396
T++S+ + W G + ++Y VQ + G +T+ T L GS
Sbjct: 218 AQTTSSISLSWEVPDGTDPQNSTYCVQCTGDG-----GRTETRNTTDTRVTVDGLGPGSL 272
Query: 397 YNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKAN-SLLISWSHGSG-NVERYRLML 454
Y ++ G S +T P+PV+++ + + N S+ ++W G + + +
Sbjct: 273 YTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGV 332
Query: 455 MDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYR-WKLVRTAPMEVSNL 513
G G T+ L PG LY +V G+ + R + TAP V NL
Sbjct: 333 EYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNL 392
Query: 514 KVTNDGSLTSLKVKWQRPPGNV-DSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLY 572
+ + +S+ + W+ P G Y + + G + T + L PG LY
Sbjct: 393 HMETQTN-SSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLY 451
Query: 573 QVTVSCVSGELSAQKMAVG-RTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLF 631
+V + V T P+ V +L + + ++ + W+ P G + +
Sbjct: 452 TFSVWAEKNGARGSRQNVSISTVPNAVTSL-SKQDWTNSTIALRWTAPQGPGQS--SYSY 508
Query: 632 NDSVVLLNITVGKEETQYVMDDT--GLVPGRQYEVEVIVESGNLKN-SERCQGRTVPLAV 688
S V +T + ++ D T L G Y + V E ++ + T P V
Sbjct: 509 WVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEV 568
Query: 689 LQLRVKHANETSLSIMWQT---PVAEWEKYIISLA---------DRDLLLIHKSLSKDAK 736
L+ + + S+ + W+ P ++ Y + A D ++++ +
Sbjct: 569 TDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNET 628
Query: 737 EFTFTDLVPGRKYMATVTSISGDLKNSS-SVKGRTVPAQVTDLHVANQGMTSSLFTNWTQ 795
+ L PG Y TV + D+ +S+ S+ T P VT + + W+
Sbjct: 629 WYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSC 688
Query: 796 AQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGI 848
QG E +++ + + ++ SS S L Y +TT+ G+
Sbjct: 689 PQGGYEAFELEVGGQR---GSQDRSSCGEAVSVLGLGPARSYPATITTIWDGM 738
Score = 59.3 bits (142), Expect = 4e-08
Identities = 93/391 (23%), Positives = 143/391 (36%), Gaps = 41/391 (10%)
Query: 1229 SLIVSWQKAAGVAER---YDILLLTENGIL-LRNTSEPATTKQHKFEDLTPGKKYKIQIL 1284
S+ +SW+ G+ + Y + + G RNT+ T + L PG Y +
Sbjct: 45 SISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVT----VDGLGPGSLYTCSVW 100
Query: 1285 TVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEG---ELSWYNIFLYNPD 1341
G+ S T P V +LR+ + ++ W +G + S Y +
Sbjct: 101 VEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG 160
Query: 1342 GNLQERAQVDPLVQSFSFQNLLQGRMYKMVI-VTHSGELSNESFIFGRTVPASVSHLRGS 1400
G R+ + + L G +Y + V +G S+ T V +LR
Sbjct: 161 GRAGTRSTAHT---NITVDGLEPGCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLR-V 216
Query: 1401 NRNTTDSLWFNWSPASGDFDFYELILYNPNG----TKKENWKDKDLTEWRFQGLVPGRKY 1456
TT S+ +W G G T+ N D +T GL PG Y
Sbjct: 217 EAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVT---VDGLGPGSLY 273
Query: 1457 VLWV-VTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSLAITWK---GPPDWTDYNDFE 1512
V V G S+ S TAP+P ++ N+S+A+TW+ GP E
Sbjct: 274 TCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVE 333
Query: 1513 LQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNV---KTVSGDSWKTYSKPIFGSV 1569
A T + N V L PG Y F+V K S +T +
Sbjct: 334 YTGDGGRAGTRSTAHTNIT-----VDRLEPGCLYVFSVWVGKNGINSSRETRN------A 382
Query: 1570 RTKPDKIQNLHCRPQNSTAIACSWIPPDSDF 1600
T P+ ++NLH Q +++IA W PD +
Sbjct: 383 TTAPNPVRNLHMETQTNSSIALCWEVPDGPY 413
Score = 43.1 bits (100), Expect = 0.003
Identities = 64/279 (22%), Positives = 107/279 (38%), Gaps = 35/279 (12%)
Query: 1404 TTDSLWFNWSPASG----DFDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLW 1459
TT S+ +W G + +++ + T+ N ++T GL PG Y
Sbjct: 42 TTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVT---VDGLGPGSLYTCS 98
Query: 1460 VVTHSGDLSNKV-TAESRTAPSPPSLMSFADIANTSLAITWK---GPPDWTDYNDFELQW 1515
V +++ V T + TAP+P + N+S+A+TW+ GP E
Sbjct: 99 VWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTG 158
Query: 1516 LPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNV---KTVSGDSWKTYSKPIFGSVRTK 1572
A T + N V GL PG Y F++ K S +T + T
Sbjct: 159 DGGRAGTRSTAHTNIT-----VDGLEPGCLYAFSMWVGKNGINSSRETRN------ATTA 207
Query: 1573 PDKIQNLHCRPQNSTAIACSWIPPDS---DFDGYSIECRKMDTQEVEFSRKLEKEKSLLN 1629
+ ++NL Q +++I+ SW PD Y ++C T + + + +
Sbjct: 208 HNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQC----TGDGGRTETRNTTDTRVT 263
Query: 1630 IMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPP 1668
+ L P Y S+ V+ G+ S V +T P P
Sbjct: 264 VDGLGPGSLYTCSVWVEKDGVNSSV---EIVTSATAPNP 299
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 252 bits (644), Expect = 2e-66
Identities = 250/953 (26%), Positives = 411/953 (43%), Gaps = 114/953 (11%)
Query: 1289 GLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERA 1348
G+ AQ + +P +TE++ ++ W + E Y I + P + +
Sbjct: 306 GVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 365
Query: 1349 QVDPLVQS-FSFQNLLQGRMY--KMVIVTHSGELSNESFIFGRT---VPASVSHLRGSNR 1402
++D + + +S L Y ++V V + G + +T P+S +
Sbjct: 366 EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARM 425
Query: 1403 NTTDSLWFNWSPA---SGDFDFYELIL-----YNPNGTKKENWKDKDLTEWRFQGLVPGR 1454
++ ++ W +G Y + + N K N D +T LVP +
Sbjct: 426 LSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT--IGNLVPQK 483
Query: 1455 KYVLWVVTHS----GDLSNKVTAESRTA-PSPPSLMSFADIANTSLAITWKGPPDWTDYN 1509
Y + V+ + G LS+ + ++T P P + TS+ ++W P T N
Sbjct: 484 TYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIAN 543
Query: 1510 DFELQWLP----RDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSKPI 1565
+EL + + P + + +G L+P Y F + S + I
Sbjct: 544 -YELVYKDGEHGEEQRITIEPGTSYRLQG-----LKPNSLYYFRLAARSPQGLGASTAEI 597
Query: 1566 FGSVRTKPDKI-QNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKE 1624
S RT +N H + T++ SW P++ + D + VE +
Sbjct: 598 --SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQ 655
Query: 1625 KSLLNIMMLVPHKRY--LVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLI 1682
K ++N L P K Y +++ + SAG V T + R P I
Sbjct: 656 KLIVN---LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKP-----------AFI 701
Query: 1683 SKSSIN--FTVNCSWFSDTNGAVKYFTVVV--READGS-------------DELKPEQQH 1725
K++++ TV Y+ ++V +++ G DEL E
Sbjct: 702 GKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISR 761
Query: 1726 PLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFC 1785
S + Y ++ Y +F E + K + GG F
Sbjct: 762 KRRS-IRYGREVELKPYIAAHFDVLPTEFTLGDDKHY-----------GG--------FT 801
Query: 1786 DGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSL-----PITTESEPLFGAIEG 1840
+ L+ Y + A + + K + YSD S+ PIT E E L +
Sbjct: 802 NKQLQSGQEYVFFVLAVME--HAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGP 859
Query: 1841 VSAGLFLIGMLVAVVALLICRQKVSHGR-ERPSARLSIRRDRPLSVH----------LNL 1889
V A +F+I + V+A+L+ + K R E S + SI ++ + H LN
Sbjct: 860 VLAVVFIICI---VIAILLYKSKPDRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNF 916
Query: 1890 GQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKN 1949
G + PI I + H +L+A+ N S+EYE + D G+ + + + L N+ KN
Sbjct: 917 QTPG-MASHPPIPILELADHIERLKANDNLKFSQEYESI-DPGQQFTWEHSNLEVNKPKN 974
Query: 1950 RYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVW 2009
RY N++ YD +RV LS ++ P SDY+NA+YI G + YI TQG LP T DFW+M+W
Sbjct: 975 RYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIW 1034
Query: 2010 EQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGE 2069
EQ +VM+T+ E+ RVKCD YWP+ + + +G + + +L L + +R F + +
Sbjct: 1035 EQRSATVVMMTKLEERSRVKCDQYWPS-RGTETHGLVQVTLLDTVELATYCVRTFALY-K 1092
Query: 2070 EQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRT 2129
R +R F +T WPDHGVPE + F+R V+ P AGP VVHCSAGVGRT
Sbjct: 1093 NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--NPPDAGPMVVHCSAGVGRT 1150
Query: 2130 GTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL 2182
G FI +D +L+++ + +VDIYG V +R R +MVQTE QY+++H + + +
Sbjct: 1151 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1203
Score = 194 bits (493), Expect = 8e-49
Identities = 103/243 (42%), Positives = 148/243 (60%), Gaps = 2/243 (0%)
Query: 1940 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1999
A LP N+ KNR NI+PY++TRV L + SDYINAS+I G ++ YI TQGPL
Sbjct: 1254 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1313
Query: 2000 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 2059
T +DFW+M+WE N +VM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1314 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1372
Query: 2060 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 2119
+REFK+ + + R +R F +T WP+ GVP++ + I F+ V + GP
Sbjct: 1373 ILREFKVT-DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1431
Query: 2120 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 2179
VHCSAGVGRTG FI L +L+++ + VDI+ V LR R MVQTE QY + ++
Sbjct: 1432 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAAL 1491
Query: 2180 DVL 2182
+ L
Sbjct: 1492 EYL 1494
Score = 50.4 bits (119), Expect = 2e-05
Identities = 97/500 (19%), Positives = 196/500 (39%), Gaps = 42/500 (8%)
Query: 1168 DSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSS 1227
D I ++V E R A Y + S G ++ + + +P G ++
Sbjct: 277 DDMPIGRNVLELNDVRQSAN--YTCVAMSTLGVIEAIAQITVKALPKP-PGTPVVTESTA 333
Query: 1228 YSLIVSWQKAAGVAERYDILL-LTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTV 1286
S+ ++W Y I+ +N L + T ++ L+P Y+ +++ V
Sbjct: 334 TSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAV 393
Query: 1287 SG---GLFSKEA--QTEGRTVPAAVTDLRITENSTRHLSFRWTASE---GELSWYNIFLY 1338
+ G S+ QT + +A D++ S+ + +W E G++ Y ++ Y
Sbjct: 394 NNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY-Y 452
Query: 1339 NPD-----GNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHS----GELSNESFIFGRT 1389
D N + D + + NL+ + Y + ++ + G LS++ + +T
Sbjct: 453 TMDPTQHVNNWMKHNVADSQITTIG--NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQT 510
Query: 1390 -VPASVSHLRGSNRNTTDSLWFNWSPASGD-FDFYELILYNPNGTKKENWKDKDLTEWRF 1447
VP + + + T S+ +W+P D YEL+ + +++ + T +R
Sbjct: 511 GVPGQPLNFKAEPESET-SILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRL 569
Query: 1448 QGLVPGRKYVLWVVTHSGDLSNKVTAE--SRTAPSP-PSLMSFADIANTSLAITWKGPPD 1504
QGL P Y + S TAE +RT S + TS+ ++W+ P +
Sbjct: 570 QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPEN 629
Query: 1505 WTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNV----KTVSGDSWKT 1560
+ F++ + D + + R ++ +++ L+P +SY F + + G +
Sbjct: 630 YNSAMPFKILY---DDGKMVEEVDGRATQ-KLIVNLKPEKSYSFVLTNRGNSAGGLQHRV 685
Query: 1561 YSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRK 1620
+K +RTKP I + + +P + + GY I + +F +
Sbjct: 686 TAKTAPDVLRTKPAFIGKTNL--DGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKP 743
Query: 1621 LEK--EKSLLNIMMLVPHKR 1638
E E L ++ + KR
Sbjct: 744 WESPDEMELDELLKEISRKR 763
Score = 43.1 bits (100), Expect = 0.003
Identities = 86/345 (24%), Positives = 135/345 (39%), Gaps = 69/345 (20%)
Query: 255 SSHSVSIQWRILGSPCN----FSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTI-- 308
SS ++ +QW+ P + + Y+ D PT ++N N+ D Q TI
Sbjct: 427 SSTTILVQWKEPEEPNGQIQGYRVYYTMD-------PTQHVNNWMKH-NVADSQITTIGN 478
Query: 309 ------YNFRIIS--------LDEERTVVLQTD-PLPPARFGVSKEKTTSTSLHVWWTPS 353
Y+ ++++ L + V+ QT P P F E TS L W P
Sbjct: 479 LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLS-WTPPR 537
Query: 354 SGKVTSYEVQLFDENNQKIQGVQIQESTSW-------NEYTFFNLTAGSKYNI-AITAVS 405
S + +YE+ D + + Q + I+ TS+ N +F L A S + A TA
Sbjct: 538 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 597
Query: 406 GGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSG-NVERYRLMLMDKGILVHGG 464
+ S++ V + +K S+L+SW N +L D G +V
Sbjct: 598 SARTMQSMFAKNFHVKAVMK--------TSVLLSWEIPENYNSAMPFKILYDDGKMVE-- 647
Query: 465 VVDKHATSYAFHGLTP--GYLYNLTVMTEAAGLQNYRW------KLVRTAPMEVSNLKVT 516
VD AT L P Y + LT +AG +R ++RT P + K
Sbjct: 648 EVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIG--KTN 705
Query: 517 NDGSLTSLKVKWQRPPG--NVDSYNITLSHKGTIKESR--VLAPW 557
DG +T V+ P N+ Y I + +K+SR + PW
Sbjct: 706 LDGMIT---VQLPEVPANENIKGYYIIIV---PLKKSRGKFIKPW 744
Score = 37.7 bits (86), Expect = 0.13
Identities = 69/312 (22%), Positives = 120/312 (38%), Gaps = 33/312 (10%)
Query: 423 PVKDIGISTKANSLLISWSHGSGN-VERYRLMLMDKGILVHGGVVDKHATS-YAFHGLTP 480
P + + A S+ ++W G+ V Y + K +D AT+ Y+ GL+P
Sbjct: 323 PGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSP 382
Query: 481 GYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDG-----SLTSLKVKWQRPP--- 532
Y V+ + + V T E + D S T++ V+W+ P
Sbjct: 383 YSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPN 442
Query: 533 GNVDSYNITLSHKGTIKESRVLAPWITE---THFKELVPGRLYQVTV----SCVSGELSA 585
G + Y + + T + + + + T LVP + Y V V S G LS+
Sbjct: 443 GQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSS 502
Query: 586 QKMAVGRT-FPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGK 644
+ +T P + N +A S+++SW+PP D + N +V + G+
Sbjct: 503 DIQVITQTGVPGQPLNFKAEPESET-SILLSWTPPRSD------TIANYELVYKDGEHGE 555
Query: 645 EETQYVMDDT-----GLVPGRQYEVEVIVES--GNLKNSERCQGRTV-PLAVLQLRVKHA 696
E+ + T GL P Y + S G ++ RT+ + VK
Sbjct: 556 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAV 615
Query: 697 NETSLSIMWQTP 708
+TS+ + W+ P
Sbjct: 616 MKTSVLLSWEIP 627
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 251 bits (640), Expect = 7e-66
Identities = 249/952 (26%), Positives = 411/952 (43%), Gaps = 116/952 (12%)
Query: 1289 GLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERA 1348
G+ AQ + +P +TE++ ++ W + E Y I + P + +
Sbjct: 309 GVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 368
Query: 1349 QVDPLVQS-FSFQNLLQGRMY--KMVIVTHSGELSNESFIFGRT---VPASVSHLRGSNR 1402
++D + + +S L Y ++V V + G + +T P+S +
Sbjct: 369 EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARM 428
Query: 1403 NTTDSLWFNWSPA---SGDFDFYELIL-----YNPNGTKKENWKDKDLTEWRFQGLVPGR 1454
++ ++ W +G Y + + N K N D +T LVP +
Sbjct: 429 LSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT--IGNLVPQK 486
Query: 1455 KYVLWVVTHS----GDLSNKVTAESRTA-PSPPSLMSFADIANTSLAITWKGPPDWTDYN 1509
Y + V+ + G LS+ + ++T P P + TS+ ++W P T N
Sbjct: 487 TYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIAN 546
Query: 1510 DFELQWLP----RDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSKPI 1565
+EL + + P + + +G L+P Y F + S + I
Sbjct: 547 -YELVYKDGEHGEEQRITIEPGTSYRLQG-----LKPNSLYYFRLAARSPQGLGASTAEI 600
Query: 1566 FGSVRTKPDKI-QNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKE 1624
S RT +N H + T++ SW P++ + D + VE +
Sbjct: 601 --SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQ 658
Query: 1625 KSLLNIMMLVPHKRY--LVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLI 1682
K ++N L P K Y +++ + SAG V T + R P I
Sbjct: 659 KLIVN---LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKP-----------AFI 704
Query: 1683 SKSSIN--FTVNCSWFSDTNGAVKYFTVVV--READGS-------------DELKPEQQH 1725
K++++ TV Y+ ++V +++ G DEL E
Sbjct: 705 GKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISR 764
Query: 1726 PLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFC 1785
S + Y ++ Y +F E + K + GG F
Sbjct: 765 KRRS-IRYGREVELKPYIAAHFDVLPTEFTLGDDKHY-----------GG--------FT 804
Query: 1786 DGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSL-----PITTESEPLFGAIEG 1840
+ L+ Y + A + + K + YSD S+ PIT E E L +
Sbjct: 805 NKQLQSGQEYVFFVLAVME--HAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGP 862
Query: 1841 VSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVH----------LNLG 1890
V A +F+I +++A+ LL R++ E S + SI ++ + H LN
Sbjct: 863 VLAVVFIICIVIAI--LLYKRKRA----ESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQ 916
Query: 1891 QKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNR 1950
G + PI I + H +L+A+ N S+EYE + D G+ + + + L N+ KNR
Sbjct: 917 TPG-MASHPPIPILELADHIERLKANDNLKFSQEYESI-DPGQQFTWEHSNLEVNKPKNR 974
Query: 1951 YNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWE 2010
Y N++ YD +RV LS ++ P SDY+NA+YI G + YI TQG LP T DFW+M+WE
Sbjct: 975 YANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWE 1034
Query: 2011 QNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEE 2070
Q +VM+T+ E+ RVKCD YWP+ + + +G + + +L L + +R F + +
Sbjct: 1035 QRSATVVMMTKLEERSRVKCDQYWPS-RGTETHGLVQVTLLDTVELATYCVRTFALY-KN 1092
Query: 2071 QLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTG 2130
R +R F +T WPDHGVPE + F+R V+ P AGP VVHCSAGVGRTG
Sbjct: 1093 GSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--NPPDAGPMVVHCSAGVGRTG 1150
Query: 2131 TFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL 2182
FI +D +L+++ + +VDIYG V +R R +MVQTE QY+++H + + +
Sbjct: 1151 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1202
Score = 194 bits (493), Expect = 8e-49
Identities = 103/243 (42%), Positives = 148/243 (60%), Gaps = 2/243 (0%)
Query: 1940 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1999
A LP N+ KNR NI+PY++TRV L + SDYINAS+I G ++ YI TQGPL
Sbjct: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312
Query: 2000 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 2059
T +DFW+M+WE N +VM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1313 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1371
Query: 2060 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 2119
+REFK+ + + R +R F +T WP+ GVP++ + I F+ V + GP
Sbjct: 1372 ILREFKVT-DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1430
Query: 2120 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 2179
VHCSAGVGRTG FI L +L+++ + VDI+ V LR R MVQTE QY + ++
Sbjct: 1431 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAAL 1490
Query: 2180 DVL 2182
+ L
Sbjct: 1491 EYL 1493
Score = 50.4 bits (119), Expect = 2e-05
Identities = 97/500 (19%), Positives = 196/500 (39%), Gaps = 42/500 (8%)
Query: 1168 DSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSS 1227
D I ++V E R A Y + S G ++ + + +P G ++
Sbjct: 280 DDMPIGRNVLELNDVRQSAN--YTCVAMSTLGVIEAIAQITVKALPKP-PGTPVVTESTA 336
Query: 1228 YSLIVSWQKAAGVAERYDILL-LTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTV 1286
S+ ++W Y I+ +N L + T ++ L+P Y+ +++ V
Sbjct: 337 TSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAV 396
Query: 1287 SG---GLFSKEA--QTEGRTVPAAVTDLRITENSTRHLSFRWTASE---GELSWYNIFLY 1338
+ G S+ QT + +A D++ S+ + +W E G++ Y ++ Y
Sbjct: 397 NNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY-Y 455
Query: 1339 NPD-----GNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHS----GELSNESFIFGRT 1389
D N + D + + NL+ + Y + ++ + G LS++ + +T
Sbjct: 456 TMDPTQHVNNWMKHNVADSQITTIG--NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQT 513
Query: 1390 -VPASVSHLRGSNRNTTDSLWFNWSPASGD-FDFYELILYNPNGTKKENWKDKDLTEWRF 1447
VP + + + T S+ +W+P D YEL+ + +++ + T +R
Sbjct: 514 GVPGQPLNFKAEPESET-SILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRL 572
Query: 1448 QGLVPGRKYVLWVVTHSGDLSNKVTAE--SRTAPSP-PSLMSFADIANTSLAITWKGPPD 1504
QGL P Y + S TAE +RT S + TS+ ++W+ P +
Sbjct: 573 QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPEN 632
Query: 1505 WTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNV----KTVSGDSWKT 1560
+ F++ + D + + R ++ +++ L+P +SY F + + G +
Sbjct: 633 YNSAMPFKILY---DDGKMVEEVDGRATQ-KLIVNLKPEKSYSFVLTNRGNSAGGLQHRV 688
Query: 1561 YSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRK 1620
+K +RTKP I + + +P + + GY I + +F +
Sbjct: 689 TAKTAPDVLRTKPAFIGKTNL--DGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKP 746
Query: 1621 LEK--EKSLLNIMMLVPHKR 1638
E E L ++ + KR
Sbjct: 747 WESPDEMELDELLKEISRKR 766
Score = 43.1 bits (100), Expect = 0.003
Identities = 86/345 (24%), Positives = 135/345 (39%), Gaps = 69/345 (20%)
Query: 255 SSHSVSIQWRILGSPCN----FSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTI-- 308
SS ++ +QW+ P + + Y+ D PT ++N N+ D Q TI
Sbjct: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMD-------PTQHVNNWMKH-NVADSQITTIGN 481
Query: 309 ------YNFRIIS--------LDEERTVVLQTD-PLPPARFGVSKEKTTSTSLHVWWTPS 353
Y+ ++++ L + V+ QT P P F E TS L W P
Sbjct: 482 LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLS-WTPPR 540
Query: 354 SGKVTSYEVQLFDENNQKIQGVQIQESTSW-------NEYTFFNLTAGSKYNI-AITAVS 405
S + +YE+ D + + Q + I+ TS+ N +F L A S + A TA
Sbjct: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
Query: 406 GGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSG-NVERYRLMLMDKGILVHGG 464
+ S++ V + +K S+L+SW N +L D G +V
Sbjct: 601 SARTMQSMFAKNFHVKAVMK--------TSVLLSWEIPENYNSAMPFKILYDDGKMVE-- 650
Query: 465 VVDKHATSYAFHGLTP--GYLYNLTVMTEAAGLQNYRW------KLVRTAPMEVSNLKVT 516
VD AT L P Y + LT +AG +R ++RT P + K
Sbjct: 651 EVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIG--KTN 708
Query: 517 NDGSLTSLKVKWQRPPG--NVDSYNITLSHKGTIKESR--VLAPW 557
DG +T V+ P N+ Y I + +K+SR + PW
Sbjct: 709 LDGMIT---VQLPEVPANENIKGYYIIIV---PLKKSRGKFIKPW 747
Score = 37.7 bits (86), Expect = 0.13
Identities = 69/312 (22%), Positives = 120/312 (38%), Gaps = 33/312 (10%)
Query: 423 PVKDIGISTKANSLLISWSHGSGN-VERYRLMLMDKGILVHGGVVDKHATS-YAFHGLTP 480
P + + A S+ ++W G+ V Y + K +D AT+ Y+ GL+P
Sbjct: 326 PGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSP 385
Query: 481 GYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDG-----SLTSLKVKWQRPP--- 532
Y V+ + + V T E + D S T++ V+W+ P
Sbjct: 386 YSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPN 445
Query: 533 GNVDSYNITLSHKGTIKESRVLAPWITE---THFKELVPGRLYQVTV----SCVSGELSA 585
G + Y + + T + + + + T LVP + Y V V S G LS+
Sbjct: 446 GQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSS 505
Query: 586 QKMAVGRT-FPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGK 644
+ +T P + N +A S+++SW+PP D + N +V + G+
Sbjct: 506 DIQVITQTGVPGQPLNFKAEPESET-SILLSWTPPRSD------TIANYELVYKDGEHGE 558
Query: 645 EETQYVMDDT-----GLVPGRQYEVEVIVES--GNLKNSERCQGRTV-PLAVLQLRVKHA 696
E+ + T GL P Y + S G ++ RT+ + VK
Sbjct: 559 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAV 618
Query: 697 NETSLSIMWQTP 708
+TS+ + W+ P
Sbjct: 619 MKTSVLLSWEIP 630
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 246 bits (627), Expect = 2e-64
Identities = 213/739 (28%), Positives = 340/739 (46%), Gaps = 105/739 (14%)
Query: 1492 NTSLAITWKGPPDWTD-----------YNDFELQWLPRDALTVFNPYNNRKSEGRIVYGL 1540
+TS+ ++W+ PP + Y D + LP + L V P + + + GL
Sbjct: 932 STSVQLSWQ-PPVLAERNGIITKYTLLYRDINIPLLPMEQLIV--PADTTMT----LTGL 984
Query: 1541 RPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKP-DKI--QNLHCRPQNSTAIACSWIPPD 1597
+P +Y V+ + YS + RT P D++ +N H + T++ SW P+
Sbjct: 985 KPDTTYDVKVRAHTSKGPGPYSPSV--QFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPE 1042
Query: 1598 SDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRY--LVSIKVQSAGMTSEVV 1655
+ + D + VE +K ++N L P K Y +++ + SAG V
Sbjct: 1043 NYNSAMPFKILYDDGKMVEEVDGRATQKLIVN---LKPEKSYSFVLTNRGNSAGGLQHRV 1099
Query: 1656 EDSTITMIDRPPPPPPHIRVNEKDVLISKSSIN--FTVNCSWFSDTNGAVKYFTVVV--R 1711
T + R P I K++++ TV Y+ ++V +
Sbjct: 1100 TAKTAPDVLRTKP-----------AFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLK 1148
Query: 1712 EADGS-------------DELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSN 1758
++ G DEL E S + Y ++ Y +F E +
Sbjct: 1149 KSRGKFIKPWESPDEMELDELLKEISRKRRS-IRYGREVELKPYIAAHFDVLPTEFTLGD 1207
Query: 1759 SKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLY 1818
K + GG F + L+ Y + A + + K + Y
Sbjct: 1208 DKHY-----------GG--------FTNKQLQSGQEYVFFVLAVME--HAESKMYATSPY 1246
Query: 1819 SDTFFSL-----PITTESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSA 1873
SD S+ PIT E E L + V A +F+I +++A+ LL R++ E S
Sbjct: 1247 SDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAI--LLYKRKRA----ESDSR 1300
Query: 1874 RLSIRRDRPLSVH----------LNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSK 1923
+ SI ++ + H LN G + PI I + H +L+A+ N S+
Sbjct: 1301 KSSIPNNKEIPSHHPTDPVELRRLNFQTPG-MASHPPIPILELADHIERLKANDNLKFSQ 1359
Query: 1924 EYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPG 1983
EYE + D G+ + + + L N+ KNRY N++ YD +RV LS ++ P SDY+NA+YI G
Sbjct: 1360 EYESI-DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG 1418
Query: 1984 NNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYY 2043
+ YI TQG LP T DFW+M+WEQ +VM+T+ E+ RVKCD YWP+ + + +
Sbjct: 1419 YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPS-RGTETH 1477
Query: 2044 GDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVR 2103
G + + +L L + +R F + + R +R F +T WPDHGVPE + F+R
Sbjct: 1478 GLVQVTLLDTVELATYCVRTFALY-KNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLR 1536
Query: 2104 TVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVH 2163
V+ P AGP VVHCSAGVGRTG FI +D +L+++ + +VDIYG V +R R +
Sbjct: 1537 RVKTC--NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1594
Query: 2164 MVQTECQYVYLHQCVRDVL 2182
MVQTE QY+++H + + +
Sbjct: 1595 MVQTEDQYIFIHDALLEAV 1613
Score = 194 bits (493), Expect = 8e-49
Identities = 103/243 (42%), Positives = 148/243 (60%), Gaps = 2/243 (0%)
Query: 1940 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1999
A LP N+ KNR NI+PY++TRV L + SDYINAS+I G ++ YI TQGPL
Sbjct: 1664 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1723
Query: 2000 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 2059
T +DFW+M+WE N +VM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1724 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1782
Query: 2060 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 2119
+REFK+ + + R +R F +T WP+ GVP++ + I F+ V + GP
Sbjct: 1783 ILREFKVT-DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1841
Query: 2120 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 2179
VHCSAGVGRTG FI L +L+++ + VDI+ V LR R MVQTE QY + ++
Sbjct: 1842 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAAL 1901
Query: 2180 DVL 2182
+ L
Sbjct: 1902 EYL 1904
Score = 61.6 bits (148), Expect = 8e-09
Identities = 138/715 (19%), Positives = 271/715 (37%), Gaps = 126/715 (17%)
Query: 1102 YKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAF 1161
Y + ++ G ++ A I +P ++ + AT S+T+ W G + SY +
Sbjct: 300 YTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTAT-SITLTWDSGNPEPVSYYI--I 356
Query: 1162 RHSQKVDSQTIPKHV-----FEHTFHRLEAGEQYQIMIASVSGSLKNQ-----INVVGRT 1211
+H K +S+ + K + ++ L Y+ + +V+ + +
Sbjct: 357 QHKPK-NSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQ 415
Query: 1212 VPASVQGVIADNAYSSYSLIVSWQKAA---GVAERYDILLLTE-----NGILLRNTSEPA 1263
P+S + SS +++V W++ G + Y + + N + N ++
Sbjct: 416 APSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQ 475
Query: 1264 TTKQHKFEDLTPGKKYKIQIL---TVSGGLFSKEAQTEGRT-VPAAVTDLRITENSTRHL 1319
T +L P K Y +++L ++ G S + Q +T VP + + S +
Sbjct: 476 ITT---IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532
Query: 1320 SFRWTASEGE-LSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHS-- 1376
WT + ++ Y + + + ++R ++P S+ Q L +Y + S
Sbjct: 533 LLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGT-SYRLQGLKPNSLYYFRLAARSPQ 591
Query: 1377 GELSNESFIFGRTV---PASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTK 1433
G ++ + I RT+ P++ ++ S+ +W P + + Y+ T
Sbjct: 592 GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 651
Query: 1434 KENWKDK---------DLTEWRFQGLVPGRKYVLWVVTHSG------DLSNKVTAESRTA 1478
+ DK D T++ + L +Y + V H+ LS +
Sbjct: 652 VDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVP 711
Query: 1479 PSPPSLMSFADIANTSLAITW---------------------------KGPPDWTDYNDF 1511
PP + + +TS+ ++W KG P D
Sbjct: 712 SGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLA 771
Query: 1512 ELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVK--TVSGDSWKTYSKPI--FG 1567
+ QW +++ I+ GL+P SY V T GD ++ K + G
Sbjct: 772 DAQW----------EFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTG 821
Query: 1568 SVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDF---DGYSIECRKMDTQ---EVEFSRKL 1621
+V KP + N Q +TA+ W PP F GY ++ + D + +EFS K
Sbjct: 822 AVPGKPRLVIN---HTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEK- 876
Query: 1622 EKEKSLLNIMMLVPHK--RYLVSIKVQS-AGMTSEVVEDSTITMIDRPPPPPPHIRVNEK 1678
E + +I HK Y+ + ++ G E+V++ +I P +
Sbjct: 877 EDHFTATDI-----HKGASYVFRLSARNKVGFGEEMVKEISI---------PEEVPTGFP 922
Query: 1679 DVLISKSSINFTVNCSW----FSDTNGAVKYFTVVVREADGSDELKPEQQHPLPS 1729
L S+ + + +V SW ++ NG + +T++ R D + L P +Q +P+
Sbjct: 923 QNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR--DINIPLLPMEQLIVPA 975
Score = 59.7 bits (143), Expect = 3e-08
Identities = 151/699 (21%), Positives = 251/699 (35%), Gaps = 115/699 (16%)
Query: 255 SSHSVSIQWRILGSPCN----FSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTI-- 308
SS ++ +QW+ P + + Y+ D PT ++N N+ D Q TI
Sbjct: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMD-------PTQHVNNWMKH-NVADSQITTIGN 481
Query: 309 ------YNFRIIS--------LDEERTVVLQTD-PLPPARFGVSKEKTTSTSLHVWWTPS 353
Y+ ++++ L + V+ QT P P F E TS L W P
Sbjct: 482 LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLS-WTPPR 540
Query: 354 SGKVTSYEVQLFDENNQKIQGVQIQESTSW-------NEYTFFNLTAGSKYNIAITAVSG 406
S + +YE+ D + + Q + I+ TS+ N +F L A S + +
Sbjct: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTA-- 598
Query: 407 GKRSFSVYTNGSTVPSPVKDIG-ISTKANSLLISW-----SHGSGNVERYRLMLM----- 455
S T S +P +DI S + S+L+SW +G + Y +
Sbjct: 599 ---EISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 655
Query: 456 -DKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVM--TEAAGLQNYRWKLVRT------A 506
DK + G + T Y L Y +TV T+ L+RT
Sbjct: 656 DDKPHEILG--IPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSG 713
Query: 507 PMEVSNLKVTNDGSLTSLKVKWQRP-----PGNVDSYNI--TLSHKGTIKESRVL----- 554
P ++ N TS+KV W+ P G + Y + G K +L
Sbjct: 714 PPRKVEVEAVNS---TSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVML 770
Query: 555 --APW-ITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEA-------- 603
A W +T +++ L T ++ K R+ P V+ A
Sbjct: 771 ADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLV 830
Query: 604 NNNGRMRSLVVSWSPPA---GDWEQYRILL-FNDSVVLLNITVGKEETQYVMDDTGLVPG 659
N+ +M + ++ W PP G + YR+ D L + ++E + D + G
Sbjct: 831 INHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATD--IHKG 888
Query: 660 RQYEVEVIVESGNLKNSERCQGRTVPLAV-----LQLRVKHANETSLSIMWQTPVAEWEK 714
Y + + E + ++P V L + TS+ + WQ PV
Sbjct: 889 ASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERN 948
Query: 715 YII---SLADRD----LLLIHKSLSKDAKEFTFTDLVPGRKYMATVT--SISGDLKNSSS 765
II +L RD LL + + + T T L P Y V + G S S
Sbjct: 949 GIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPS 1008
Query: 766 VKGRTVPAQ---VTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSE 822
V+ RT+P + HV M +S+ +W + +++++ + E +
Sbjct: 1009 VQFRTLPVDQVFAKNFHV-KAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMV-EEVDGR 1066
Query: 823 TSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVP 861
++ +LK YS V+T Q V +T P
Sbjct: 1067 ATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAP 1105
Score = 50.4 bits (119), Expect = 2e-05
Identities = 76/362 (20%), Positives = 147/362 (40%), Gaps = 33/362 (9%)
Query: 1168 DSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSS 1227
D I ++V E R A Y + S G ++ + + +P G ++
Sbjct: 280 DDMPIGRNVLELNDVRQSAN--YTCVAMSTLGVIEAIAQITVKALPKP-PGTPVVTESTA 336
Query: 1228 YSLIVSWQKAAGVAERYDILL-LTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTV 1286
S+ ++W Y I+ +N L + T ++ L+P Y+ +++ V
Sbjct: 337 TSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAV 396
Query: 1287 SG---GLFSKEA--QTEGRTVPAAVTDLRITENSTRHLSFRWTASE---GELSWYNIFLY 1338
+ G S+ QT + +A D++ S+ + +W E G++ Y ++ Y
Sbjct: 397 NNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY-Y 455
Query: 1339 NPD-----GNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHS----GELSNESFIFGRT 1389
D N + D + + NL+ + Y + ++ + G LS++ + +T
Sbjct: 456 TMDPTQHVNNWMKHNVADSQITTIG--NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQT 513
Query: 1390 -VPASVSHLRGSNRNTTDSLWFNWSPASGD-FDFYELILYNPNGTKKENWKDKDLTEWRF 1447
VP + + + T S+ +W+P D YEL+ + +++ + T +R
Sbjct: 514 GVPGQPLNFKAEPESET-SILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRL 572
Query: 1448 QGLVPGRKYVLWVVTHSGDLSNKVTAE--SRTAPS----PPSLMSFADIANTSLAITWKG 1501
QGL P Y + S TAE +RT S PP +S ++TS+ ++W+
Sbjct: 573 QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQP 632
Query: 1502 PP 1503
PP
Sbjct: 633 PP 634
Score = 50.4 bits (119), Expect = 2e-05
Identities = 137/713 (19%), Positives = 263/713 (36%), Gaps = 91/713 (12%)
Query: 1014 YSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGD-VDQYEIQLL 1072
Y+ + G EA Q + +P+P + + + +TW N + V Y IQ
Sbjct: 300 YTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHK 359
Query: 1073 -FNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTIS----GDVQQSAFIE-GFTVPS 1126
N +++ V T T Y L+P Y+ V+ ++ G + + PS
Sbjct: 360 PKNSEELYKEIDGVAT-TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPS 418
Query: 1127 AVKNIHISPNGATDSLTVNWTPG---GGDVDSYTVSAFRHSQKVDSQTIPKHVFEH---T 1180
+ + ++ ++ V W G + Y V + + + +V + T
Sbjct: 419 SAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT 478
Query: 1181 FHRLEAGEQYQIMIASVS----GSLKNQINVVGRT-VPASVQGVIADNAYSSYSLIVSWQ 1235
L + Y + + + + G L + I V+ +T VP A+ S S+++SW
Sbjct: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPE-SETSILLSWT 537
Query: 1236 KA-AGVAERYDILLLT-ENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSG-GLFS 1292
+ Y+++ E+G R T EP T+ ++ + L P Y ++ S GL +
Sbjct: 538 PPRSDTIANYELVYKDGEHGEEQRITIEPGTS--YRLQGLKPNSLYYFRLAARSPQGLGA 595
Query: 1293 KEAQTEGRTVP----AAVTDLRITENSTRHLSFRWTA-----SEGELSWYNIFLYNPDGN 1343
A+ RT+ A D+ T S+ + W G ++ Y+I DG
Sbjct: 596 STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 655
Query: 1344 LQERAQVDPL---VQSFSFQNLLQGRMYKMVIVTHS--GELSNESFIFGRT---VPASVS 1395
+ ++ + + + L + Y++ + H+ G + RT VP+
Sbjct: 656 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPP 715
Query: 1396 HLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKENWKDKDL----------TEW 1445
+ S+ +W + ++ Y + + EN + K +W
Sbjct: 716 RKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQW 775
Query: 1446 RFQ----------GLVPGRKYVLWVVTHS--GDLSN---KVTAESRTAPSPPSLMSFADI 1490
F GL P Y L V ++ GD + K+ + + P P L+
Sbjct: 776 EFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQ 835
Query: 1491 ANTSLAITWKGPPD-WTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFN 1549
NT+L I W P D + + L++ +D + + K + + G SY F
Sbjct: 836 MNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFR 894
Query: 1550 VKTVSGDSWKTYSKPIFGSVRTK----PDKI-----QNLHCRPQNSTAIACSWIPP---- 1596
+ +K FG K P+++ QNLH ST++ SW PP
Sbjct: 895 LSA--------RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAE 946
Query: 1597 -DSDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSA 1648
+ Y++ R ++ + + + + + + L P Y V ++ ++
Sbjct: 947 RNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTS 999
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 246 bits (627), Expect = 2e-64
Identities = 213/739 (28%), Positives = 340/739 (46%), Gaps = 105/739 (14%)
Query: 1492 NTSLAITWKGPPDWTD-----------YNDFELQWLPRDALTVFNPYNNRKSEGRIVYGL 1540
+TS+ ++W+ PP + Y D + LP + L V P + + + GL
Sbjct: 919 STSVQLSWQ-PPVLAERNGIITKYTLLYRDINIPLLPMEQLIV--PADTTMT----LTGL 971
Query: 1541 RPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKP-DKI--QNLHCRPQNSTAIACSWIPPD 1597
+P +Y V+ + YS + RT P D++ +N H + T++ SW P+
Sbjct: 972 KPDTTYDVKVRAHTSKGPGPYSPSV--QFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPE 1029
Query: 1598 SDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRY--LVSIKVQSAGMTSEVV 1655
+ + D + VE +K ++N L P K Y +++ + SAG V
Sbjct: 1030 NYNSAMPFKILYDDGKMVEEVDGRATQKLIVN---LKPEKSYSFVLTNRGNSAGGLQHRV 1086
Query: 1656 EDSTITMIDRPPPPPPHIRVNEKDVLISKSSIN--FTVNCSWFSDTNGAVKYFTVVV--R 1711
T + R P I K++++ TV Y+ ++V +
Sbjct: 1087 TAKTAPDVLRTKP-----------AFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLK 1135
Query: 1712 EADGS-------------DELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSN 1758
++ G DEL E S + Y ++ Y +F E +
Sbjct: 1136 KSRGKFIKPWESPDEMELDELLKEISRKRRS-IRYGREVELKPYIAAHFDVLPTEFTLGD 1194
Query: 1759 SKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLY 1818
K + GG F + L+ Y + A + + K + Y
Sbjct: 1195 DKHY-----------GG--------FTNKQLQSGQEYVFFVLAVME--HAESKMYATSPY 1233
Query: 1819 SDTFFSL-----PITTESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSA 1873
SD S+ PIT E E L + V A +F+I +++A+ LL R++ E S
Sbjct: 1234 SDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAI--LLYKRKRA----ESDSR 1287
Query: 1874 RLSIRRDRPLSVH----------LNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSK 1923
+ SI ++ + H LN G + PI I + H +L+A+ N S+
Sbjct: 1288 KSSIPNNKEIPSHHPTDPVELRRLNFQTPG-MASHPPIPILELADHIERLKANDNLKFSQ 1346
Query: 1924 EYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPG 1983
EYE + D G+ + + + L N+ KNRY N++ YD +RV LS ++ P SDY+NA+YI G
Sbjct: 1347 EYESI-DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG 1405
Query: 1984 NNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYY 2043
+ YI TQG LP T DFW+M+WEQ +VM+T+ E+ RVKCD YWP+ + + +
Sbjct: 1406 YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPS-RGTETH 1464
Query: 2044 GDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVR 2103
G + + +L L + +R F + + R +R F +T WPDHGVPE + F+R
Sbjct: 1465 GLVQVTLLDTVELATYCVRTFALY-KNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLR 1523
Query: 2104 TVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVH 2163
V+ P AGP VVHCSAGVGRTG FI +D +L+++ + +VDIYG V +R R +
Sbjct: 1524 RVKTC--NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1581
Query: 2164 MVQTECQYVYLHQCVRDVL 2182
MVQTE QY+++H + + +
Sbjct: 1582 MVQTEDQYIFIHDALLEAV 1600
Score = 194 bits (493), Expect = 8e-49
Identities = 103/243 (42%), Positives = 148/243 (60%), Gaps = 2/243 (0%)
Query: 1940 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1999
A LP N+ KNR NI+PY++TRV L + SDYINAS+I G ++ YI TQGPL
Sbjct: 1651 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1710
Query: 2000 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 2059
T +DFW+M+WE N +VM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1711 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1769
Query: 2060 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 2119
+REFK+ + + R +R F +T WP+ GVP++ + I F+ V + GP
Sbjct: 1770 ILREFKVT-DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1828
Query: 2120 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 2179
VHCSAGVGRTG FI L +L+++ + VDI+ V LR R MVQTE QY + ++
Sbjct: 1829 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAAL 1888
Query: 2180 DVL 2182
+ L
Sbjct: 1889 EYL 1891
Score = 61.6 bits (148), Expect = 8e-09
Identities = 138/715 (19%), Positives = 271/715 (37%), Gaps = 126/715 (17%)
Query: 1102 YKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAF 1161
Y + ++ G ++ A I +P ++ + AT S+T+ W G + SY +
Sbjct: 287 YTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTAT-SITLTWDSGNPEPVSYYI--I 343
Query: 1162 RHSQKVDSQTIPKHV-----FEHTFHRLEAGEQYQIMIASVSGSLKNQ-----INVVGRT 1211
+H K +S+ + K + ++ L Y+ + +V+ + +
Sbjct: 344 QHKPK-NSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQ 402
Query: 1212 VPASVQGVIADNAYSSYSLIVSWQKAA---GVAERYDILLLTE-----NGILLRNTSEPA 1263
P+S + SS +++V W++ G + Y + + N + N ++
Sbjct: 403 APSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQ 462
Query: 1264 TTKQHKFEDLTPGKKYKIQIL---TVSGGLFSKEAQTEGRT-VPAAVTDLRITENSTRHL 1319
T +L P K Y +++L ++ G S + Q +T VP + + S +
Sbjct: 463 ITT---IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 519
Query: 1320 SFRWTASEGE-LSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHS-- 1376
WT + ++ Y + + + ++R ++P S+ Q L +Y + S
Sbjct: 520 LLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGT-SYRLQGLKPNSLYYFRLAARSPQ 578
Query: 1377 GELSNESFIFGRTV---PASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTK 1433
G ++ + I RT+ P++ ++ S+ +W P + + Y+ T
Sbjct: 579 GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 638
Query: 1434 KENWKDK---------DLTEWRFQGLVPGRKYVLWVVTHSG------DLSNKVTAESRTA 1478
+ DK D T++ + L +Y + V H+ LS +
Sbjct: 639 VDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVP 698
Query: 1479 PSPPSLMSFADIANTSLAITW---------------------------KGPPDWTDYNDF 1511
PP + + +TS+ ++W KG P D
Sbjct: 699 SGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLA 758
Query: 1512 ELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVK--TVSGDSWKTYSKPI--FG 1567
+ QW +++ I+ GL+P SY V T GD ++ K + G
Sbjct: 759 DAQW----------EFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTG 808
Query: 1568 SVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDF---DGYSIECRKMDTQ---EVEFSRKL 1621
+V KP + N Q +TA+ W PP F GY ++ + D + +EFS K
Sbjct: 809 AVPGKPRLVIN---HTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEK- 863
Query: 1622 EKEKSLLNIMMLVPHK--RYLVSIKVQS-AGMTSEVVEDSTITMIDRPPPPPPHIRVNEK 1678
E + +I HK Y+ + ++ G E+V++ +I P +
Sbjct: 864 EDHFTATDI-----HKGASYVFRLSARNKVGFGEEMVKEISI---------PEEVPTGFP 909
Query: 1679 DVLISKSSINFTVNCSW----FSDTNGAVKYFTVVVREADGSDELKPEQQHPLPS 1729
L S+ + + +V SW ++ NG + +T++ R D + L P +Q +P+
Sbjct: 910 QNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR--DINIPLLPMEQLIVPA 962
Score = 59.7 bits (143), Expect = 3e-08
Identities = 151/699 (21%), Positives = 251/699 (35%), Gaps = 115/699 (16%)
Query: 255 SSHSVSIQWRILGSPCN----FSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTI-- 308
SS ++ +QW+ P + + Y+ D PT ++N N+ D Q TI
Sbjct: 417 SSTTILVQWKEPEEPNGQIQGYRVYYTMD-------PTQHVNNWMKH-NVADSQITTIGN 468
Query: 309 ------YNFRIIS--------LDEERTVVLQTD-PLPPARFGVSKEKTTSTSLHVWWTPS 353
Y+ ++++ L + V+ QT P P F E TS L W P
Sbjct: 469 LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLS-WTPPR 527
Query: 354 SGKVTSYEVQLFDENNQKIQGVQIQESTSW-------NEYTFFNLTAGSKYNIAITAVSG 406
S + +YE+ D + + Q + I+ TS+ N +F L A S + +
Sbjct: 528 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTA-- 585
Query: 407 GKRSFSVYTNGSTVPSPVKDIG-ISTKANSLLISW-----SHGSGNVERYRLMLM----- 455
S T S +P +DI S + S+L+SW +G + Y +
Sbjct: 586 ---EISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 642
Query: 456 -DKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVM--TEAAGLQNYRWKLVRT------A 506
DK + G + T Y L Y +TV T+ L+RT
Sbjct: 643 DDKPHEILG--IPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSG 700
Query: 507 PMEVSNLKVTNDGSLTSLKVKWQRP-----PGNVDSYNI--TLSHKGTIKESRVL----- 554
P ++ N TS+KV W+ P G + Y + G K +L
Sbjct: 701 PPRKVEVEAVNS---TSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVML 757
Query: 555 --APW-ITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVANLEA-------- 603
A W +T +++ L T ++ K R+ P V+ A
Sbjct: 758 ADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLV 817
Query: 604 NNNGRMRSLVVSWSPPA---GDWEQYRILL-FNDSVVLLNITVGKEETQYVMDDTGLVPG 659
N+ +M + ++ W PP G + YR+ D L + ++E + D + G
Sbjct: 818 INHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATD--IHKG 875
Query: 660 RQYEVEVIVESGNLKNSERCQGRTVPLAV-----LQLRVKHANETSLSIMWQTPVAEWEK 714
Y + + E + ++P V L + TS+ + WQ PV
Sbjct: 876 ASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERN 935
Query: 715 YII---SLADRD----LLLIHKSLSKDAKEFTFTDLVPGRKYMATVT--SISGDLKNSSS 765
II +L RD LL + + + T T L P Y V + G S S
Sbjct: 936 GIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPS 995
Query: 766 VKGRTVPAQ---VTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSE 822
V+ RT+P + HV M +S+ +W + +++++ + E +
Sbjct: 996 VQFRTLPVDQVFAKNFHV-KAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMV-EEVDGR 1053
Query: 823 TSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVP 861
++ +LK YS V+T Q V +T P
Sbjct: 1054 ATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAP 1092
Score = 50.4 bits (119), Expect = 2e-05
Identities = 76/362 (20%), Positives = 147/362 (40%), Gaps = 33/362 (9%)
Query: 1168 DSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSS 1227
D I ++V E R A Y + S G ++ + + +P G ++
Sbjct: 267 DDMPIGRNVLELNDVRQSAN--YTCVAMSTLGVIEAIAQITVKALPKP-PGTPVVTESTA 323
Query: 1228 YSLIVSWQKAAGVAERYDILL-LTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTV 1286
S+ ++W Y I+ +N L + T ++ L+P Y+ +++ V
Sbjct: 324 TSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAV 383
Query: 1287 SG---GLFSKEA--QTEGRTVPAAVTDLRITENSTRHLSFRWTASE---GELSWYNIFLY 1338
+ G S+ QT + +A D++ S+ + +W E G++ Y ++ Y
Sbjct: 384 NNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY-Y 442
Query: 1339 NPD-----GNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHS----GELSNESFIFGRT 1389
D N + D + + NL+ + Y + ++ + G LS++ + +T
Sbjct: 443 TMDPTQHVNNWMKHNVADSQITTIG--NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQT 500
Query: 1390 -VPASVSHLRGSNRNTTDSLWFNWSPASGD-FDFYELILYNPNGTKKENWKDKDLTEWRF 1447
VP + + + T S+ +W+P D YEL+ + +++ + T +R
Sbjct: 501 GVPGQPLNFKAEPESET-SILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRL 559
Query: 1448 QGLVPGRKYVLWVVTHSGDLSNKVTAE--SRTAPS----PPSLMSFADIANTSLAITWKG 1501
QGL P Y + S TAE +RT S PP +S ++TS+ ++W+
Sbjct: 560 QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQP 619
Query: 1502 PP 1503
PP
Sbjct: 620 PP 621
Score = 50.4 bits (119), Expect = 2e-05
Identities = 137/713 (19%), Positives = 263/713 (36%), Gaps = 91/713 (12%)
Query: 1014 YSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGD-VDQYEIQLL 1072
Y+ + G EA Q + +P+P + + + +TW N + V Y IQ
Sbjct: 287 YTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHK 346
Query: 1073 -FNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTIS----GDVQQSAFIE-GFTVPS 1126
N +++ V T T Y L+P Y+ V+ ++ G + + PS
Sbjct: 347 PKNSEELYKEIDGVAT-TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPS 405
Query: 1127 AVKNIHISPNGATDSLTVNWTPG---GGDVDSYTVSAFRHSQKVDSQTIPKHVFEH---T 1180
+ + ++ ++ V W G + Y V + + + +V + T
Sbjct: 406 SAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT 465
Query: 1181 FHRLEAGEQYQIMIASVS----GSLKNQINVVGRT-VPASVQGVIADNAYSSYSLIVSWQ 1235
L + Y + + + + G L + I V+ +T VP A+ S S+++SW
Sbjct: 466 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPE-SETSILLSWT 524
Query: 1236 KA-AGVAERYDILLLT-ENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSG-GLFS 1292
+ Y+++ E+G R T EP T+ ++ + L P Y ++ S GL +
Sbjct: 525 PPRSDTIANYELVYKDGEHGEEQRITIEPGTS--YRLQGLKPNSLYYFRLAARSPQGLGA 582
Query: 1293 KEAQTEGRTVP----AAVTDLRITENSTRHLSFRWTA-----SEGELSWYNIFLYNPDGN 1343
A+ RT+ A D+ T S+ + W G ++ Y+I DG
Sbjct: 583 STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 642
Query: 1344 LQERAQVDPL---VQSFSFQNLLQGRMYKMVIVTHS--GELSNESFIFGRT---VPASVS 1395
+ ++ + + + L + Y++ + H+ G + RT VP+
Sbjct: 643 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPP 702
Query: 1396 HLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKENWKDKDL----------TEW 1445
+ S+ +W + ++ Y + + EN + K +W
Sbjct: 703 RKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQW 762
Query: 1446 RFQ----------GLVPGRKYVLWVVTHS--GDLSN---KVTAESRTAPSPPSLMSFADI 1490
F GL P Y L V ++ GD + K+ + + P P L+
Sbjct: 763 EFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQ 822
Query: 1491 ANTSLAITWKGPPD-WTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFN 1549
NT+L I W P D + + L++ +D + + K + + G SY F
Sbjct: 823 MNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFR 881
Query: 1550 VKTVSGDSWKTYSKPIFGSVRTK----PDKI-----QNLHCRPQNSTAIACSWIPP---- 1596
+ +K FG K P+++ QNLH ST++ SW PP
Sbjct: 882 LSA--------RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAE 933
Query: 1597 -DSDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSA 1648
+ Y++ R ++ + + + + + + L P Y V ++ ++
Sbjct: 934 RNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTS 986
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 246 bits (627), Expect = 2e-64
Identities = 213/739 (28%), Positives = 340/739 (46%), Gaps = 105/739 (14%)
Query: 1492 NTSLAITWKGPPDWTD-----------YNDFELQWLPRDALTVFNPYNNRKSEGRIVYGL 1540
+TS+ ++W+ PP + Y D + LP + L V P + + + GL
Sbjct: 923 STSVQLSWQ-PPVLAERNGIITKYTLLYRDINIPLLPMEQLIV--PADTTMT----LTGL 975
Query: 1541 RPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKP-DKI--QNLHCRPQNSTAIACSWIPPD 1597
+P +Y V+ + YS + RT P D++ +N H + T++ SW P+
Sbjct: 976 KPDTTYDVKVRAHTSKGPGPYSPSV--QFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPE 1033
Query: 1598 SDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRY--LVSIKVQSAGMTSEVV 1655
+ + D + VE +K ++N L P K Y +++ + SAG V
Sbjct: 1034 NYNSAMPFKILYDDGKMVEEVDGRATQKLIVN---LKPEKSYSFVLTNRGNSAGGLQHRV 1090
Query: 1656 EDSTITMIDRPPPPPPHIRVNEKDVLISKSSIN--FTVNCSWFSDTNGAVKYFTVVV--R 1711
T + R P I K++++ TV Y+ ++V +
Sbjct: 1091 TAKTAPDVLRTKP-----------AFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLK 1139
Query: 1712 EADGS-------------DELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSN 1758
++ G DEL E S + Y ++ Y +F E +
Sbjct: 1140 KSRGKFIKPWESPDEMELDELLKEISRKRRS-IRYGREVELKPYIAAHFDVLPTEFTLGD 1198
Query: 1759 SKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLY 1818
K + GG F + L+ Y + A + + K + Y
Sbjct: 1199 DKHY-----------GG--------FTNKQLQSGQEYVFFVLAVME--HAESKMYATSPY 1237
Query: 1819 SDTFFSL-----PITTESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSA 1873
SD S+ PIT E E L + V A +F+I +++A+ LL R++ E S
Sbjct: 1238 SDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAI--LLYKRKRA----ESDSR 1291
Query: 1874 RLSIRRDRPLSVH----------LNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSK 1923
+ SI ++ + H LN G + PI I + H +L+A+ N S+
Sbjct: 1292 KSSIPNNKEIPSHHPTDPVELRRLNFQTPG-MASHPPIPILELADHIERLKANDNLKFSQ 1350
Query: 1924 EYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPG 1983
EYE + D G+ + + + L N+ KNRY N++ YD +RV LS ++ P SDY+NA+YI G
Sbjct: 1351 EYESI-DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG 1409
Query: 1984 NNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYY 2043
+ YI TQG LP T DFW+M+WEQ +VM+T+ E+ RVKCD YWP+ + + +
Sbjct: 1410 YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPS-RGTETH 1468
Query: 2044 GDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVR 2103
G + + +L L + +R F + + R +R F +T WPDHGVPE + F+R
Sbjct: 1469 GLVQVTLLDTVELATYCVRTFALY-KNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLR 1527
Query: 2104 TVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVH 2163
V+ P AGP VVHCSAGVGRTG FI +D +L+++ + +VDIYG V +R R +
Sbjct: 1528 RVKTC--NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1585
Query: 2164 MVQTECQYVYLHQCVRDVL 2182
MVQTE QY+++H + + +
Sbjct: 1586 MVQTEDQYIFIHDALLEAV 1604
Score = 194 bits (493), Expect = 8e-49
Identities = 103/243 (42%), Positives = 148/243 (60%), Gaps = 2/243 (0%)
Query: 1940 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1999
A LP N+ KNR NI+PY++TRV L + SDYINAS+I G ++ YI TQGPL
Sbjct: 1655 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1714
Query: 2000 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 2059
T +DFW+M+WE N +VM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1715 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1773
Query: 2060 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 2119
+REFK+ + + R +R F +T WP+ GVP++ + I F+ V + GP
Sbjct: 1774 ILREFKVT-DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1832
Query: 2120 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 2179
VHCSAGVGRTG FI L +L+++ + VDI+ V LR R MVQTE QY + ++
Sbjct: 1833 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAAL 1892
Query: 2180 DVL 2182
+ L
Sbjct: 1893 EYL 1895
Score = 62.0 bits (149), Expect = 6e-09
Identities = 151/691 (21%), Positives = 248/691 (35%), Gaps = 108/691 (15%)
Query: 255 SSHSVSIQWRILGSPCN----FSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTI-- 308
SS ++ +QW+ P + + Y+ D PT ++N N+ D Q TI
Sbjct: 430 SSTTILVQWKEPEEPNGQIQGYRVYYTMD-------PTQHVNNWMKH-NVADSQITTIGN 481
Query: 309 ------YNFRIIS--------LDEERTVVLQTD-PLPPARFGVSKEKTTSTSLHVWWTPS 353
Y+ ++++ L + V+ QT P P F E TS L W P
Sbjct: 482 LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLS-WTPPR 540
Query: 354 SGKVTSYEVQLFDENNQKIQGVQIQESTSW-------NEYTFFNLTAGSKYNIAITAVSG 406
S + +YE+ D + + Q + I+ TS+ N +F L A S + +
Sbjct: 541 SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTA-- 598
Query: 407 GKRSFSVYTNGSTVPSPVKDIG-ISTKANSLLISW-----SHGSGNVERYRLMLM----- 455
S T S +P +DI S + S+L+SW +G + Y +
Sbjct: 599 ---EISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 655
Query: 456 -DKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVM--TEAAGLQNYRWKLVRT------A 506
DK + G + T Y L Y +TV T+ L+RT
Sbjct: 656 DDKPHEILG--IPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSG 713
Query: 507 PMEVSNLKVTNDGSLTSLKVKWQRP-----PGNVDSYNITL------SHKGTIKESRVLA 555
P ++ N TS+KV W+ P G + Y + KG V+
Sbjct: 714 PPRKVEVEAVNS---TSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVML 770
Query: 556 PWITETHFKELVPGRLYQVTVSCVS----GELSAQKMAVGRTFPDKVANLEANNNGRMRS 611
+ L P Y +TV+ + G S K+ V T N+ +M +
Sbjct: 771 ADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKL-VSTTGAVPGKPRLVINHTQMNT 829
Query: 612 LVVSWSPPA---GDWEQYRILL-FNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVI 667
++ W PP G + YR+ D L + ++E + D + G Y +
Sbjct: 830 ALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATD--IHKGASYVFRLS 887
Query: 668 VESGNLKNSERCQGRTVPLAV-----LQLRVKHANETSLSIMWQTPVAEWEKYII---SL 719
+ E + ++P V L + TS+ + WQ PV II +L
Sbjct: 888 ARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTL 947
Query: 720 ADRD----LLLIHKSLSKDAKEFTFTDLVPGRKYMATVT--SISGDLKNSSSVKGRTVPA 773
RD LL + + + T T L P Y V + G S SV+ RT+P
Sbjct: 948 LYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPV 1007
Query: 774 Q---VTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHS 830
+ HV M +S+ +W + +++++ + E + ++ +
Sbjct: 1008 DQVFAKNFHV-KAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMV-EEVDGRATQKLIVN 1065
Query: 831 LKSGSLYSVVVTTVSGGISSRQVVVEGRTVP 861
LK YS V+T Q V +T P
Sbjct: 1066 LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAP 1096
Score = 58.2 bits (139), Expect = 9e-08
Identities = 82/345 (23%), Positives = 137/345 (39%), Gaps = 29/345 (8%)
Query: 1403 NTTDSLWFNWSPASGDFDFYELILYNPNGTKKENWKDKD---LTEWRFQGLVPGRKYVLW 1459
+T S+ W + + Y +I + P ++ E +K+ D T + GL P Y
Sbjct: 334 STATSITLTWDSGNPEPVSYYIIQHKPKNSE-ELYKEIDGVATTRYSVAGLSPYSDYEFR 392
Query: 1460 VVTHS----GDLSNKV-TAESRTAPSP-PSLMSFADIANTSLAITWKGPPDWT-DYNDFE 1512
VV + G S V T S APS P + +++T++ + WK P + +
Sbjct: 393 VVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYR 452
Query: 1513 LQWL--PRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVR 1570
+ + P + + +N S+ + L P ++Y V + S I +
Sbjct: 453 VYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQ 512
Query: 1571 TK-PDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKEKSLLN 1629
T P + N P++ T+I SW PP SD + E D + E R + +
Sbjct: 513 TGVPGQPLNFKAEPESETSILLSWTPPRSDTIA-NYELVYKDGEHGEEQRITIEPGTSYR 571
Query: 1630 IMMLVPHKRYLVSIKVQS-AGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSIN 1688
+ L P+ Y + +S G+ + E S TM +P PP I S SS +
Sbjct: 572 LQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT------SPSSTS 625
Query: 1689 FTVNCSW----FSDTNGAVKYFTVVVREADGSDELKPEQQHPLPS 1729
V SW NG + +++ DG D+ KP + +PS
Sbjct: 626 ILV--SWQPPPVEKQNGIITEYSIKYTAVDGEDD-KPHEILGIPS 667
Score = 52.8 bits (125), Expect = 4e-06
Identities = 136/704 (19%), Positives = 262/704 (37%), Gaps = 82/704 (11%)
Query: 1014 YSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGD-VDQYEIQLL 1072
Y+ + G EA Q + +P+P + + + +TW N + V Y IQ
Sbjct: 300 YTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHK 359
Query: 1073 -FNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTIS----GDVQQSAFIE-GFTVPS 1126
N +++ V T T Y L+P Y+ V+ ++ G + + PS
Sbjct: 360 PKNSEELYKEIDGVAT-TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPS 418
Query: 1127 AVKNIHISPNGATDSLTVNWTPG---GGDVDSYTVSAFRHSQKVDSQTIPKHVFEH---T 1180
+ + ++ ++ V W G + Y V + + + +V + T
Sbjct: 419 SAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT 478
Query: 1181 FHRLEAGEQYQIMIASVS----GSLKNQINVVGRT-VPASVQGVIADNAYSSYSLIVSWQ 1235
L + Y + + + + G L + I V+ +T VP A+ S S+++SW
Sbjct: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPE-SETSILLSWT 537
Query: 1236 KA-AGVAERYDILLLT-ENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSG-GLFS 1292
+ Y+++ E+G R T EP T+ ++ + L P Y ++ S GL +
Sbjct: 538 PPRSDTIANYELVYKDGEHGEEQRITIEPGTS--YRLQGLKPNSLYYFRLAARSPQGLGA 595
Query: 1293 KEAQTEGRTVP----AAVTDLRITENSTRHLSFRWTA-----SEGELSWYNIFLYNPDGN 1343
A+ RT+ A D+ T S+ + W G ++ Y+I DG
Sbjct: 596 STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 655
Query: 1344 LQERAQVDPL---VQSFSFQNLLQGRMYKMVIVTHS--GELSNESFIFGRT---VPASVS 1395
+ ++ + + + L + Y++ + H+ G + RT VP+
Sbjct: 656 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPP 715
Query: 1396 HLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKENWKDK-----------DLTE 1444
+ S+ +W + ++ Y + + EN + K D +
Sbjct: 716 RKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQD 775
Query: 1445 WRFQGLVPGRKYVLWVVTHS--GDLSN---KVTAESRTAPSPPSLMSFADIANTSLAITW 1499
GL P Y L V ++ GD + K+ + + P P L+ NT+L I W
Sbjct: 776 MIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL-IQW 834
Query: 1500 KGPPD-WTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSW 1558
P D + + L++ +D + + K + + G SY F +
Sbjct: 835 HPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSA------ 888
Query: 1559 KTYSKPIFGSVRTK----PDKI-----QNLHCRPQNSTAIACSWIPP-----DSDFDGYS 1604
+K FG K P+++ QNLH ST++ SW PP + Y+
Sbjct: 889 --RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYT 946
Query: 1605 IECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSA 1648
+ R ++ + + + + + + L P Y V ++ ++
Sbjct: 947 LLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTS 990
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 245 bits (625), Expect = 4e-64
Identities = 129/278 (46%), Positives = 176/278 (63%), Gaps = 6/278 (2%)
Query: 1901 IKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDAT 1960
I++ H +++ Y +EYE L + G+ S D A ENR KNRY NI+ YD +
Sbjct: 869 IRVADLLQHITQMKRGQGYGFKEEYEALPE-GQTASWDTAKEDENRNKNRYGNIISYDHS 927
Query: 1961 RVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVT 2020
RV+L +D DP SDYINA+YI G + R YI TQGP+ T DFW+M+W++N +IVMVT
Sbjct: 928 RVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT 987
Query: 2021 QCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRH 2080
VE GRVKC YWP D + YGD+ + ++ L E+ IR F + ++ R +R
Sbjct: 988 NLVEVGRVKCVRYWPDDTE--VYGDIKVTLIETEPLAEYVIRTFTV-QKKGYHEIRELRL 1044
Query: 2081 FHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQ 2140
FH+T WPDHGVP L+ FVR V+ ++N P AGP VVHCSAG GRTG FIA+D +L
Sbjct: 1045 FHFTSWPDHGVPCYATGLLGFVRQVK-FLN-PPEAGPIVVHCSAGAGRTGCFIAIDTMLD 1102
Query: 2141 QLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 2178
+++ VDI+ V +LR RV++VQTE QYV++H +
Sbjct: 1103 MAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1140
Score = 142 bits (357), Expect = 5e-33
Identities = 82/253 (32%), Positives = 145/253 (57%), Gaps = 7/253 (2%)
Query: 1933 RNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIV 1992
R + C I LLP N KNR ++LP D L +VD + S+YINA+ + + ++V
Sbjct: 1190 RPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVV 1248
Query: 1993 TQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLS 2052
TQ PLP T DFW++V++ N ++VM+ + ++ + C YWP ++ S YG + ++ +S
Sbjct: 1249 TQHPLPNTVADFWRLVFDYNCSSVVMLNE-MDTAQF-CMQYWP-EKTSGCYGPIQVEFVS 1305
Query: 2053 ESVLPEWTIREFKICGEEQ-LDAHRLIRHFHYTVWPDH-GVPETTQSLIQFVRTVRDYIN 2110
+ + R F+IC + D +R+++H Y WP + P + +SL++ VR + +
Sbjct: 1306 ADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQE 1365
Query: 2111 RSPGA-GPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTEC 2169
+ G G TVVHC G GR+GTF A+ + + + ++ +D++ V LR ++ +MV+T
Sbjct: 1366 QYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLE 1425
Query: 2170 QYVYLHQCVRDVL 2182
QY ++++ + L
Sbjct: 1426 QYKFVYEVALEYL 1438
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 245 bits (625), Expect = 4e-64
Identities = 129/278 (46%), Positives = 176/278 (63%), Gaps = 6/278 (2%)
Query: 1901 IKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDAT 1960
I++ H +++ Y +EYE L + G+ S D A ENR KNRY NI+ YD +
Sbjct: 888 IRVADLLQHITQMKRGQGYGFKEEYEALPE-GQTASWDTAKEDENRNKNRYGNIISYDHS 946
Query: 1961 RVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVT 2020
RV+L +D DP SDYINA+YI G + R YI TQGP+ T DFW+M+W++N +IVMVT
Sbjct: 947 RVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT 1006
Query: 2021 QCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRH 2080
VE GRVKC YWP D + YGD+ + ++ L E+ IR F + ++ R +R
Sbjct: 1007 NLVEVGRVKCVRYWPDDTE--VYGDIKVTLIETEPLAEYVIRTFTV-QKKGYHEIRELRL 1063
Query: 2081 FHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQ 2140
FH+T WPDHGVP L+ FVR V+ ++N P AGP VVHCSAG GRTG FIA+D +L
Sbjct: 1064 FHFTSWPDHGVPCYATGLLGFVRQVK-FLN-PPEAGPIVVHCSAGAGRTGCFIAIDTMLD 1121
Query: 2141 QLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 2178
+++ VDI+ V +LR RV++VQTE QYV++H +
Sbjct: 1122 MAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1159
Score = 142 bits (357), Expect = 5e-33
Identities = 82/253 (32%), Positives = 145/253 (57%), Gaps = 7/253 (2%)
Query: 1933 RNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIV 1992
R + C I LLP N KNR ++LP D L +VD + S+YINA+ + + ++V
Sbjct: 1209 RPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVV 1267
Query: 1993 TQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLS 2052
TQ PLP T DFW++V++ N ++VM+ + ++ + C YWP ++ S YG + ++ +S
Sbjct: 1268 TQHPLPNTVADFWRLVFDYNCSSVVMLNE-MDTAQF-CMQYWP-EKTSGCYGPIQVEFVS 1324
Query: 2053 ESVLPEWTIREFKICGEEQ-LDAHRLIRHFHYTVWPDH-GVPETTQSLIQFVRTVRDYIN 2110
+ + R F+IC + D +R+++H Y WP + P + +SL++ VR + +
Sbjct: 1325 ADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQE 1384
Query: 2111 RSPGA-GPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTEC 2169
+ G G TVVHC G GR+GTF A+ + + + ++ +D++ V LR ++ +MV+T
Sbjct: 1385 QYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLE 1444
Query: 2170 QYVYLHQCVRDVL 2182
QY ++++ + L
Sbjct: 1445 QYKFVYEVALEYL 1457
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 243 bits (620), Expect = 2e-63
Identities = 218/779 (27%), Positives = 345/779 (44%), Gaps = 86/779 (11%)
Query: 1440 KDLTEWRFQGLVPGRKYVLWVVTHS-GDLSNKVTAESRTAPSPPS----LMSFADIANTS 1494
KD + GL G Y+ + + L + E RT PS + + ++
Sbjct: 872 KDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTST 931
Query: 1495 LAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI-------VYGLRPGRSYQ 1547
+ W PP + N + + VF N+++ I + GL+P +Y
Sbjct: 932 TELAWD-PPVLAERNGRIISYT-----VVFRDINSQQELQNITTDTRFTLTGLKPDTTYD 985
Query: 1548 FNVKTVSGDSWKTYSKPIFGSVRTKPDKIQ-----NLHCRPQNSTAIACSWIPPDSD--- 1599
V+ + S P+ S++++ ++ N T++ SW PDS
Sbjct: 986 IKVRAWTSKG----SGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSA 1041
Query: 1600 ------FDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRY--LVSIKVQSAGMT 1651
++G S+E + RKL I L P+ Y ++ + SAG
Sbjct: 1042 VPFKILYNGQSVEV------DGHSMRKL--------IADLQPNTEYSFVLMNRGSSAGGL 1087
Query: 1652 SEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVR 1711
+V T + P P + + +S + WF Y VV
Sbjct: 1088 QHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWF--------YIVVVPI 1139
Query: 1712 EADGSDELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEME 1771
+ G L P P L+ A + + + AE + + + E
Sbjct: 1140 DRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAA-QLDVLPETF 1198
Query: 1772 SLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFS--LPITT 1829
+LG K + F + PL P +Y+ + A + D K + YSD P
Sbjct: 1199 TLGDK--KNYRGFYNRPLSPDLSYQCFVLASLKE-PMDQKRYASSPYSDEIVVQVTPAQQ 1255
Query: 1830 ESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSAR----------LSIRR 1879
+ EP + G + LI ++ V+A+L+ ++K +H PS++ L
Sbjct: 1256 QEEPEMLWVTGPVLAVILI--ILIVIAILLFKRKRTHS---PSSKDEQSIGLKDSLLAHS 1310
Query: 1880 DRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDI 1939
P+ + Q + PI I + +L+A+ S+EYE + D G+ + +
Sbjct: 1311 SDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESI-DPGQQFTWEN 1369
Query: 1940 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1999
+ L N+ KNRY N++ YD +RV L+++D P SDYINA+YI G + YI TQGPLP
Sbjct: 1370 SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPE 1429
Query: 2000 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 2059
T DFW+MVWEQ +VM+T+ EK RVKCD YWPA + + G + + +L L +
Sbjct: 1430 TMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPA-RGTETCGLIQVTLLDTVELATY 1488
Query: 2060 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 2119
T+R F + + R +R F + WPDHGVPE ++ F+R V+ AGP V
Sbjct: 1489 TVRTFAL-HKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVK--ACNPLDAGPMV 1545
Query: 2120 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 2178
VHCSAGVGRTG FI +D +L+++ + +VDIYG V +R R +MVQTE QYV++H+ +
Sbjct: 1546 VHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL 1604
Score = 192 bits (489), Expect = 2e-48
Identities = 103/243 (42%), Positives = 146/243 (60%), Gaps = 2/243 (0%)
Query: 1940 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1999
A LP N+ KNR NI+PY+ TRV L + SDYINAS++ G ++ YI TQGPL
Sbjct: 1659 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1718
Query: 2000 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 2059
+ +DFW+M+WE N IVM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1719 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1777
Query: 2060 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 2119
+REFK+ + + R IR F +T WP+ GVP+T + I F+ V + GP
Sbjct: 1778 ILREFKVT-DARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPIT 1836
Query: 2120 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 2179
VHCSAGVGRTG FI L +L+++ + VD++ V LR R MVQTE QY ++
Sbjct: 1837 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAAL 1896
Query: 2180 DVL 2182
+ L
Sbjct: 1897 EYL 1899
Score = 50.1 bits (118), Expect = 2e-05
Identities = 134/695 (19%), Positives = 244/695 (35%), Gaps = 86/695 (12%)
Query: 996 IPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHV 1055
+P N +V Y+ + G EA Q + +P+P DL + + + +
Sbjct: 278 MPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTL 337
Query: 1056 TWSGANGD-VDQYEIQLLFNDMKVFPPFHLVN--TATEYRFTSLTPGRQYKILVLTIS-- 1110
TW N + V Y IQ + PF V+ T Y L+P +Y VL ++
Sbjct: 338 TWDSGNSEPVTYYGIQ--YRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSI 395
Query: 1111 GDVQQSAFIE---GFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKV 1167
G S + G PS+ + + ++ V W P + + V +R
Sbjct: 396 GRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP--PEEPNGLVRGYRVYYTP 453
Query: 1168 DSQTIPKHVFEH--------TFHRLEAGEQYQIMIASVSG----------SLKNQINVVG 1209
DS+ P +H T L G Y + + + + +K Q V
Sbjct: 454 DSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPA 513
Query: 1210 RTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTSEPATTKQHK 1269
+ PA Q + + S ++ Q+ + Y+++ ++ T +
Sbjct: 514 Q--PADFQAEVESDTRIQLSWLLPPQERIIM---YELVYWAAEDEDQQHKVTFDPTSSYT 568
Query: 1270 FEDLTPGKKYKIQILTVSG---GLFSK--EAQTEGRTVPAAVTDLRITENSTRHLSFRWT 1324
EDL P Y+ Q+ S G+F+ EA+T T A + + + W
Sbjct: 569 LEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
Query: 1325 -----ASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLL---QGRMYKMVIVTHS 1376
+ G ++ Y++ DG + R VD + + S +L+ + Y++ + H+
Sbjct: 629 PPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT 688
Query: 1377 --GELSNESFIFGRT---VPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNG 1431
G S + RT VP+ + ++ W ++ Y
Sbjct: 689 DVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTY 748
Query: 1432 TKKENWKDKDL----------TEWR----------FQGLVPGRKYVLWVV--THSGDLSN 1469
+ EN + + L +WR GL P Y + V T GD +
Sbjct: 749 VRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGAR 808
Query: 1470 ---KVTAESRTAPSPPSLMSFADIANTSLAITWKGPPDWT-DYNDFELQWLPRDALTVFN 1525
K+ + P P++M NT+L + W P + + + LQ+ D
Sbjct: 809 SKPKIVTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARPNT 867
Query: 1526 PYNNRKSEGRIVYGLRPGRSYQFNVKTVS-GDSWKTYSKPIFGSVRTKPDKIQNLHCRPQ 1584
+ + V GL G +Y F + + + + K I QNLH
Sbjct: 868 IDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGL 927
Query: 1585 NSTAIACSWIPP-----DSDFDGYSIECRKMDTQE 1614
++ +W PP + Y++ R +++Q+
Sbjct: 928 TTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQ 962
Score = 48.5 bits (114), Expect = 7e-05
Identities = 133/693 (19%), Positives = 256/693 (36%), Gaps = 97/693 (13%)
Query: 1102 YKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAF 1161
Y + ++ G ++ +A + +P ++ ++ AT S+T+ W G + +Y +
Sbjct: 296 YTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTAT-SVTLTWDSGNSEPVTYYGIQY 354
Query: 1162 RHS------QKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVS----GSLKNQINV-VGR 1210
R + Q+VD ++ + L +Y + +V+ G + G
Sbjct: 355 RAAGTEGPFQEVDGVATTRY----SIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGE 410
Query: 1211 TVPASVQGVIADNAYSSYSLIVSWQ---KAAGVAERYDILLLTE-----NGILLRNTSEP 1262
P+S + S+ +++V W+ + G+ Y + + N NT
Sbjct: 411 QAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAG 470
Query: 1263 ATTKQHKFEDLTPGKKYKIQILT---VSGGLFSKEAQTEGRT-VPAAVTDLRITENSTRH 1318
T L PG Y +++L V G S Q + + VPA D + S
Sbjct: 471 LLTT---VGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTR 527
Query: 1319 LSFRWTASEGE--LSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHS 1376
+ W E + + ++ D + Q + DP S++ ++L +Y+ + S
Sbjct: 528 IQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDP-TSSYTLEDLKPDTLYRFQLAARS 586
Query: 1377 --GELSNESFIFGRTVPASVSH-----LRGSNRNTTDSLWFNWSPASGDFD--------- 1420
G I RT ++ S + S +TT + +W P D
Sbjct: 587 DMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRV--SWVPPPADSRNGVITQYSV 644
Query: 1421 FYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHS----GDLSNKVTAES- 1475
YE + G + ++ + W GL +Y +WV H+ G S+ V +
Sbjct: 645 AYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTD 704
Query: 1476 RTAPS-PPSLMSFADIANTSLAITWKGPPDWTDYNDF-------------ELQWLP--RD 1519
PS PP + + +T++ + WK P + E + LP +D
Sbjct: 705 EDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQD 764
Query: 1520 ALTVFNPYNNRKSEG--RIVYGLRPGRSYQFNVK--TVSGDSWKTYSKPIF--GSVRTKP 1573
+ + +SE + GL P +Y V T GD ++ K + G+V +P
Sbjct: 765 VMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRP 824
Query: 1574 DKIQNLHCRPQNSTAIACSWIPPDS---DFDGYSIE-CRKMDTQE--VEFSRKLEKEKSL 1627
+ + N+ + W PP + GY ++ CR + + ++F K+
Sbjct: 825 TMM--ISTTAMNTALL--QWHPPKELPGELLGYRLQYCRADEARPNTIDFG----KDDQH 876
Query: 1628 LNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSI 1687
+ L Y+ + ++ E E T D P P ++ V ++ S+
Sbjct: 877 FTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTG----LTTSTT 932
Query: 1688 NFTVNCSWFSDTNGAVKYFTVVVREADGSDELK 1720
+ ++ NG + +TVV R+ + EL+
Sbjct: 933 ELAWDPPVLAERNGRIISYTVVFRDINSQQELQ 965
Score = 44.7 bits (104), Expect = 0.001
Identities = 90/353 (25%), Positives = 137/353 (38%), Gaps = 63/353 (17%)
Query: 318 EERTVVLQTD---PLPPARFGVSKEKTTSTSLHVWW---TPSS--GKVTSYEVQLFDENN 369
E V+++TD P P R V E ST++HV+W PS G++ Y+V N
Sbjct: 695 ESSPVLVRTDEDVPSGPPR-KVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLEN 753
Query: 370 QKIQGVQI------------QESTSWNEYTFFNLTAGSKYNIAITAVS----GGKRSFSV 413
+ +G+ I E + E T LT + Y++ + A + G + +
Sbjct: 754 GEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKI 813
Query: 414 YTNGSTVPSPVKDIGISTKANSLLISW---SHGSGNVERYRLMLM----DKGILVHGGVV 466
T VP + +T N+ L+ W G + YRL + + G
Sbjct: 814 VTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKD 873
Query: 467 DKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEV-----SNLKVTNDGSL 521
D+H T H T Y++ L AGL K +RT P ++ NL VT +
Sbjct: 874 DQHFTVTGLHKGTT-YIFRLAAKNR-AGLGEEFEKEIRT-PEDLPSGFPQNLHVTGLTTS 930
Query: 522 TSLKVKWQRP-----PGNVDSYNITLSHKGTIKESRVLAPWITETHF--KELVPGRLYQV 574
T+ ++ W P G + SY + I + L T+T F L P Y +
Sbjct: 931 TT-ELAWDPPVLAERNGRIISYTVVFR---DINSQQELQNITTDTRFTLTGLKPDTTYDI 986
Query: 575 TV----SCVSGELSAQKMAVGRTFPDKVANLEANN----NGRMRSLVVSWSPP 619
V S SG LS + RT P V + A N S+++SW P
Sbjct: 987 KVRAWTSKGSGPLSPSIQS--RTMP--VEQVFAKNFRVAAAMKTSVLLSWEVP 1035
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 243 bits (620), Expect = 2e-63
Identities = 218/779 (27%), Positives = 345/779 (44%), Gaps = 86/779 (11%)
Query: 1440 KDLTEWRFQGLVPGRKYVLWVVTHS-GDLSNKVTAESRTAPSPPS----LMSFADIANTS 1494
KD + GL G Y+ + + L + E RT PS + + ++
Sbjct: 863 KDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTST 922
Query: 1495 LAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI-------VYGLRPGRSYQ 1547
+ W PP + N + + VF N+++ I + GL+P +Y
Sbjct: 923 TELAWD-PPVLAERNGRIISYT-----VVFRDINSQQELQNITTDTRFTLTGLKPDTTYD 976
Query: 1548 FNVKTVSGDSWKTYSKPIFGSVRTKPDKIQ-----NLHCRPQNSTAIACSWIPPDSD--- 1599
V+ + S P+ S++++ ++ N T++ SW PDS
Sbjct: 977 IKVRAWTSKG----SGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSA 1032
Query: 1600 ------FDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRY--LVSIKVQSAGMT 1651
++G S+E + RKL I L P+ Y ++ + SAG
Sbjct: 1033 VPFKILYNGQSVEV------DGHSMRKL--------IADLQPNTEYSFVLMNRGSSAGGL 1078
Query: 1652 SEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVR 1711
+V T + P P + + +S + WF Y VV
Sbjct: 1079 QHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWF--------YIVVVPI 1130
Query: 1712 EADGSDELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEME 1771
+ G L P P L+ A + + + AE + + + E
Sbjct: 1131 DRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAA-QLDVLPETF 1189
Query: 1772 SLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFS--LPITT 1829
+LG K + F + PL P +Y+ + A + D K + YSD P
Sbjct: 1190 TLGDK--KNYRGFYNRPLSPDLSYQCFVLASLKE-PMDQKRYASSPYSDEIVVQVTPAQQ 1246
Query: 1830 ESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSAR----------LSIRR 1879
+ EP + G + LI ++ V+A+L+ ++K +H PS++ L
Sbjct: 1247 QEEPEMLWVTGPVLAVILI--ILIVIAILLFKRKRTHS---PSSKDEQSIGLKDSLLAHS 1301
Query: 1880 DRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDI 1939
P+ + Q + PI I + +L+A+ S+EYE + D G+ + +
Sbjct: 1302 SDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESI-DPGQQFTWEN 1360
Query: 1940 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1999
+ L N+ KNRY N++ YD +RV L+++D P SDYINA+YI G + YI TQGPLP
Sbjct: 1361 SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPE 1420
Query: 2000 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 2059
T DFW+MVWEQ +VM+T+ EK RVKCD YWPA + + G + + +L L +
Sbjct: 1421 TMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPA-RGTETCGLIQVTLLDTVELATY 1479
Query: 2060 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 2119
T+R F + + R +R F + WPDHGVPE ++ F+R V+ AGP V
Sbjct: 1480 TVRTFAL-HKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVK--ACNPLDAGPMV 1536
Query: 2120 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 2178
VHCSAGVGRTG FI +D +L+++ + +VDIYG V +R R +MVQTE QYV++H+ +
Sbjct: 1537 VHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL 1595
Score = 192 bits (489), Expect = 2e-48
Identities = 103/243 (42%), Positives = 146/243 (60%), Gaps = 2/243 (0%)
Query: 1940 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1999
A LP N+ KNR NI+PY+ TRV L + SDYINAS++ G ++ YI TQGPL
Sbjct: 1650 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1709
Query: 2000 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 2059
+ +DFW+M+WE N IVM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1710 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1768
Query: 2060 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 2119
+REFK+ + + R IR F +T WP+ GVP+T + I F+ V + GP
Sbjct: 1769 ILREFKVT-DARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPIT 1827
Query: 2120 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 2179
VHCSAGVGRTG FI L +L+++ + VD++ V LR R MVQTE QY ++
Sbjct: 1828 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAAL 1887
Query: 2180 DVL 2182
+ L
Sbjct: 1888 EYL 1890
Score = 51.2 bits (121), Expect = 1e-05
Identities = 133/686 (19%), Positives = 242/686 (35%), Gaps = 77/686 (11%)
Query: 996 IPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHV 1055
+P N +V Y+ + G EA Q + +P+P DL + + + +
Sbjct: 278 MPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTL 337
Query: 1056 TWSGANGD-VDQYEIQLLFNDMKVFPPFHLVN--TATEYRFTSLTPGRQYKILVLTIS-- 1110
TW N + V Y IQ + PF V+ T Y L+P +Y VL ++
Sbjct: 338 TWDSGNSEPVTYYGIQ--YRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSI 395
Query: 1111 GDVQQSAFIE---GFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKV 1167
G S + G PS+ + + ++ V W P + + V +R
Sbjct: 396 GRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP--PEEPNGLVRGYRVYYTP 453
Query: 1168 DSQTIPKHVFEH--------TFHRLEAGEQYQIMIASVSG----------SLKNQINVVG 1209
DS+ P +H T L G Y + + + + +K Q V
Sbjct: 454 DSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPA 513
Query: 1210 RTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTSEPATTKQHK 1269
+ PA Q + + S ++ Q+ + Y+++ ++ T +
Sbjct: 514 Q--PADFQAEVESDTRIQLSWLLPPQERIIM---YELVYWAAEDEDQQHKVTFDPTSSYT 568
Query: 1270 FEDLTPGKKYKIQILTVSG---GLFSK--EAQTEGRTVPAAVTDLRITENSTRHLSFRWT 1324
EDL P Y+ Q+ S G+F+ EA+T T A + + + W
Sbjct: 569 LEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
Query: 1325 -----ASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLL---QGRMYKMVIVTHS 1376
+ G ++ Y++ DG + R VD + + S +L+ + Y++ + H+
Sbjct: 629 PPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT 688
Query: 1377 --GELSNESFIFGRT---VPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNG 1431
G S + RT VP+ + ++ W ++ Y
Sbjct: 689 DVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTY 748
Query: 1432 TKKENWKDKDL-----------TEWRFQGLVPGRKYVLWVV--THSGDLSN---KVTAES 1475
+ EN + + L E GL P Y + V T GD + K+ +
Sbjct: 749 VRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTT 808
Query: 1476 RTAPSPPSLMSFADIANTSLAITWKGPPDWT-DYNDFELQWLPRDALTVFNPYNNRKSEG 1534
P P++M NT+L + W P + + + LQ+ D + +
Sbjct: 809 GAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQH 867
Query: 1535 RIVYGLRPGRSYQFNVKTVS-GDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSW 1593
V GL G +Y F + + + + K I QNLH ++ +W
Sbjct: 868 FTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAW 927
Query: 1594 IPP-----DSDFDGYSIECRKMDTQE 1614
PP + Y++ R +++Q+
Sbjct: 928 DPPVLAERNGRIISYTVVFRDINSQQ 953
Score = 50.1 bits (118), Expect = 2e-05
Identities = 130/685 (18%), Positives = 257/685 (37%), Gaps = 90/685 (13%)
Query: 1102 YKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAF 1161
Y + ++ G ++ +A + +P ++ ++ AT S+T+ W G + +Y +
Sbjct: 296 YTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTAT-SVTLTWDSGNSEPVTYYGIQY 354
Query: 1162 RHS------QKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVS----GSLKNQINV-VGR 1210
R + Q+VD ++ + L +Y + +V+ G + G
Sbjct: 355 RAAGTEGPFQEVDGVATTRY----SIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGE 410
Query: 1211 TVPASVQGVIADNAYSSYSLIVSWQ---KAAGVAERYDILLLTE-----NGILLRNTSEP 1262
P+S + S+ +++V W+ + G+ Y + + N NT
Sbjct: 411 QAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAG 470
Query: 1263 ATTKQHKFEDLTPGKKYKIQILT---VSGGLFSKEAQTEGRT-VPAAVTDLRITENSTRH 1318
T L PG Y +++L V G S Q + + VPA D + S
Sbjct: 471 LLTT---VGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTR 527
Query: 1319 LSFRWTASEGE--LSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHS 1376
+ W E + + ++ D + Q + DP S++ ++L +Y+ + S
Sbjct: 528 IQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDP-TSSYTLEDLKPDTLYRFQLAARS 586
Query: 1377 --GELSNESFIFGRTVPASVSH-----LRGSNRNTTDSLWFNWSPASGDFD--------- 1420
G I RT ++ S + S +TT + +W P D
Sbjct: 587 DMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRV--SWVPPPADSRNGVITQYSV 644
Query: 1421 FYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHS----GDLSNKVTAES- 1475
YE + G + ++ + W GL +Y +WV H+ G S+ V +
Sbjct: 645 AYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTD 704
Query: 1476 RTAPS-PPSLMSFADIANTSLAITWKGPPDWTDYND---FELQWL------PRDALTVFN 1525
PS PP + + +T++ + WK P + +++ ++ PR L +
Sbjct: 705 EDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPR-GLPIIQ 763
Query: 1526 PYNNRKSEGRIVYGLRPGRSYQFNVK--TVSGDSWKTYSKPIF--GSVRTKPDKIQNLHC 1581
+++ + GL P +Y V T GD ++ K + G+V +P + +
Sbjct: 764 DVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMM--IST 821
Query: 1582 RPQNSTAIACSWIPPDS---DFDGYSIE-CRKMDTQE--VEFSRKLEKEKSLLNIMMLVP 1635
N+ + W PP + GY ++ CR + + ++F K+ + L
Sbjct: 822 TAMNTALL--QWHPPKELPGELLGYRLQYCRADEARPNTIDFG----KDDQHFTVTGLHK 875
Query: 1636 HKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSW 1695
Y+ + ++ E E T D P P ++ V ++ S+ +
Sbjct: 876 GTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTG----LTTSTTELAWDPPV 931
Query: 1696 FSDTNGAVKYFTVVVREADGSDELK 1720
++ NG + +TVV R+ + EL+
Sbjct: 932 LAERNGRIISYTVVFRDINSQQELQ 956
Score = 47.0 bits (110), Expect = 2e-04
Identities = 89/344 (25%), Positives = 136/344 (39%), Gaps = 54/344 (15%)
Query: 318 EERTVVLQTD---PLPPARFGVSKEKTTSTSLHVWW---TPSS--GKVTSYEVQLFDENN 369
E V+++TD P P R V E ST++HV+W PS G++ Y+V N
Sbjct: 695 ESSPVLVRTDEDVPSGPPR-KVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLEN 753
Query: 370 QKIQGVQIQES---TSWNEYTFFNLTAGSKYNIAITAVS----GGKRSFSVYTNGSTVPS 422
+ +G+ I + E T LT + Y++ + A + G + + T VP
Sbjct: 754 GEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPG 813
Query: 423 PVKDIGISTKANSLLISW---SHGSGNVERYRLMLM----DKGILVHGGVVDKHATSYAF 475
+ +T N+ L+ W G + YRL + + G D+H T
Sbjct: 814 RPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGL 873
Query: 476 HGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEV-----SNLKVTNDGSLTSLKVKWQR 530
H T Y++ L AGL K +RT P ++ NL VT + T+ ++ W
Sbjct: 874 HKGTT-YIFRLAAKNR-AGLGEEFEKEIRT-PEDLPSGFPQNLHVTGLTTSTT-ELAWDP 929
Query: 531 P-----PGNVDSYNITLSHKGTIKESRVLAPWITETHF--KELVPGRLYQVTV----SCV 579
P G + SY + I + L T+T F L P Y + V S
Sbjct: 930 PVLAERNGRIISYTVVFR---DINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKG 986
Query: 580 SGELSAQKMAVGRTFPDKVANLEANN----NGRMRSLVVSWSPP 619
SG LS + RT P V + A N S+++SW P
Sbjct: 987 SGPLSPSIQS--RTMP--VEQVFAKNFRVAAAMKTSVLLSWEVP 1026
Score = 44.3 bits (103), Expect = 0.001
Identities = 143/674 (21%), Positives = 249/674 (36%), Gaps = 85/674 (12%)
Query: 611 SLVVSWSPPA---GDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTG-LVPGRQYEVEV 666
+++V W PP G YR+ DS N ++ G L+PG Y + V
Sbjct: 429 TMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRV 488
Query: 667 IVES--GNLKNSERCQGRT---VPLAVLQLRVKHANETSLSIMWQTPVAE----WEKYII 717
+ + G+ S Q +T VP + + ++T + + W P E +E
Sbjct: 489 LAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYW 548
Query: 718 SLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSIS--GDLKNSSSVKGRTVP--- 772
+ D D HK +T DL P Y + + S G + +++ RT
Sbjct: 549 AAEDEDQQ--HKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTP 606
Query: 773 -AQVTDLHVANQGMTSSLFTNWTQAQGDVE---FYQVLLIHENVVIKN------ESISSE 822
A + + G T+ + +W D Q + +E V ++ + IS E
Sbjct: 607 SAPPQKVMCVSMGSTT-VRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE 665
Query: 823 TSRYSFHSLKSGSLYSVVV---TTVSGGISSRQVVVE-GRTVPSSVSGVTVNNSGRNDYL 878
S + L+ + Y V V T V G S V+V VPS + +
Sbjct: 666 HSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAV 725
Query: 879 SVSWLLAP-----GDVDNYEVTLSH--DGK-----VVQSLVIAKSVRECSFSSLTPGRLY 926
V W L G + Y+VT +G+ ++Q +++A++ +E + S LTP Y
Sbjct: 726 HVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEA-QETTISGLTPETTY 784
Query: 927 TVTITTRSGKYEN-HSFSQERTVPDKVQG---VSVSNSARSDYLRVSW---VHATGDFDH 979
+VT+ + K + S + T V G + +S +A + L + W G+
Sbjct: 785 SVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLG 843
Query: 980 YEVTIKNKNNF-IQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPE 1038
Y + + T K + L G Y + K+ E PE
Sbjct: 844 YRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPE 903
Query: 1039 PV-----KDLTLRNRSTEDLHVTW-----SGANGDVDQYEIQLLFNDMKVFPPFHLVNTA 1088
+ ++L + +T + W + NG + Y + +F D+ + T
Sbjct: 904 DLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTV--VFRDINSQQELQNITTD 961
Query: 1089 TEYRFTSLTPGRQY--KILVLTISGDVQQSAFIEGFTVPSA---VKNIHISPNGATDSLT 1143
T + T L P Y K+ T G S I+ T+P KN ++ T S+
Sbjct: 962 TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKT-SVL 1020
Query: 1144 VNWTPGGGDVDSY-TVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMI---ASVSG 1199
++W DSY + F+ S + H L+ +Y ++ S +G
Sbjct: 1021 LSWEV----PDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAG 1076
Query: 1200 SLKNQINVVGRTVP 1213
L++ +++ RT P
Sbjct: 1077 GLQHLVSI--RTAP 1088
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 238 bits (607), Expect = 5e-62
Identities = 246/952 (25%), Positives = 401/952 (42%), Gaps = 112/952 (11%)
Query: 1289 GLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLY---NPDGNLQ 1345
G+ AQ +++P A +TEN+ ++ W + + Y + Y + DG Q
Sbjct: 309 GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQ 368
Query: 1346 ERAQVDPLVQSFSFQNLLQGRMYKMVI--VTHSGELSNESFIFGRT---VPASVSHLRGS 1400
+ + +S L Y++ + V G+ + RT PAS +
Sbjct: 369 IKEDIT--TTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQA 426
Query: 1401 NRNTTDSLWFNWSPA-------SGDFDFYELILYNPNGT-KKENWKDKDLTEWRFQGLVP 1452
+ ++ W G +Y + +P G +K N D LT L+
Sbjct: 427 RMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT--VGSLLE 484
Query: 1453 GRKYVLWVVTHS----GDLSNKVTAESRTA-PSPPSLMSFADIANTSLAITWKGPPDWTD 1507
Y + V+ + G LS+ + +++ P P + + TS+ ++W PP
Sbjct: 485 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS-PPRQES 543
Query: 1508 YNDFELQWLP----RDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSK 1563
+EL + R+ F+P + +V L+P Y F + S ++
Sbjct: 544 IIKYELLFREGDHGREVGRTFDP-----TTSYVVEDLKPNTEYAFRLAARSPQGLGAFT- 597
Query: 1564 PIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDS---------DFDGYSIECRKMDTQE 1614
P+ + +N + T++ SW PD+ ++G +++ T++
Sbjct: 598 PVVRQRTLQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKK 657
Query: 1615 VEFSRKLEKEKSLLNIMMLVPHKRY---LVSIKVQSAGMTSEVVEDSTITMIDRPPPPPP 1671
+ I L PH Y L + G+ V + +++ P P
Sbjct: 658 L--------------ITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP 703
Query: 1672 HIRVNEKDVLISKSSINFTVNCSWFSDTNGAV---KYFTVVV--READGSDELKPEQQHP 1726
+ D I + D V YF V+V R++ G L P P
Sbjct: 704 K---PDADGFIMV----------YLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGS-P 749
Query: 1727 LPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQK--- 1783
LE R+ + + S+ E P + A L P QK
Sbjct: 750 EDMDLEELIQDISRLQRRSLRHSRQLEVPRPY-------IAARFSVLPPTFHPGDQKQYG 802
Query: 1784 -FCDGPLKPHTAYRISIRAFTQLFDEDL--KEFTKPLYSDTFFSLPITTESEPLFGAIEG 1840
F + L+P Y + + A Q + F+ P D PI E L I
Sbjct: 803 GFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGP 862
Query: 1841 VSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDR----------PLSVHLNLG 1890
V A +F+I + V+A+L+ + K R+ R + P+ +
Sbjct: 863 VLAVVFIICI---VIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINF 919
Query: 1891 QKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNR 1950
Q + PI I H +L+A+ + LS+EYE + D G+ + + + L N+ KNR
Sbjct: 920 QTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESI-DPGQQFTWEHSNLEVNKPKNR 978
Query: 1951 YNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWE 2010
Y N++ YD +RV L ++ SDYINA+Y+ G + YI TQGPLP T DFW+MVWE
Sbjct: 979 YANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWE 1038
Query: 2011 QNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEE 2070
Q IVM+T+ EK R+KCD YWP ++ + YG + + +L L + +R F + +
Sbjct: 1039 QRSATIVMMTRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSL-HKN 1096
Query: 2071 QLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTG 2130
R +R F +T WPDHGVPE + F+R V+ P AGP VVHCSAGVGRTG
Sbjct: 1097 GSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC--NPPDAGPIVVHCSAGVGRTG 1154
Query: 2131 TFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL 2182
FI +D +L+++ + +VD+YG V +R R +MVQTE QY ++H+ + + +
Sbjct: 1155 CFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1206
Score = 195 bits (495), Expect = 5e-49
Identities = 103/243 (42%), Positives = 148/243 (60%), Gaps = 2/243 (0%)
Query: 1940 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1999
A LP N+ KNR NI+PY++TRV L + SDYINAS+I G ++ YI TQGPL
Sbjct: 1257 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1316
Query: 2000 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 2059
T +DFW+M+WE N +VM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1317 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1375
Query: 2060 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 2119
+REFK+ + + R +R F +T WP+ GVP++ + I F+ V + GP
Sbjct: 1376 ILREFKVT-DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1434
Query: 2120 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 2179
VHCSAGVGRTG FI L +L+++ + VDI+ V LR R MVQTE +Y + +Q
Sbjct: 1435 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL 1494
Query: 2180 DVL 2182
+ L
Sbjct: 1495 EYL 1497
Score = 43.1 bits (100), Expect = 0.003
Identities = 59/306 (19%), Positives = 117/306 (38%), Gaps = 31/306 (10%)
Query: 1094 TSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDV 1153
T + Y + ++ G ++ A I ++P A ++ N AT S+T+ W G D
Sbjct: 292 TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTAT-SITITWDSGNPDP 350
Query: 1154 DSYTVSAFRHSQKVDSQTIPKHV--FEHTFHRLEAGEQYQIMIASVSG-----SLKNQIN 1206
SY V ++ + I + + ++ L +Y+I +++V+ ++ +
Sbjct: 351 VSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVT 410
Query: 1207 VVGRTVPASVQGVIADNAYSSYSLIVSWQKAA---GVAERYDILLLTENGILLRNTSEPA 1263
G PAS + S+ ++IV W++ G+ Y + E + N
Sbjct: 411 RTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGN----- 465
Query: 1264 TTKQHKFED--------LTPGKKYKIQIL---TVSGGLFSKEAQTEGRT-VPAAVTDLRI 1311
++H +D L + Y +++L +V G S Q + + VP +LR
Sbjct: 466 -WQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRA 524
Query: 1312 TENSTRHLSFRWTASEGE-LSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKM 1370
S ++ W+ E + Y + D + DP S+ ++L Y
Sbjct: 525 EARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDP-TTSYVVEDLKPNTEYAF 583
Query: 1371 VIVTHS 1376
+ S
Sbjct: 584 RLAARS 589
Score = 36.6 bits (83), Expect = 0.28
Identities = 63/267 (23%), Positives = 101/267 (37%), Gaps = 63/267 (23%)
Query: 484 YNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRP-PGNVDSYNITL 542
Y M+ ++ V++ P VT + + TS+ + W P V Y I
Sbjct: 300 YTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVT-ENTATSITITWDSGNPDPVSYYVIEY 358
Query: 543 SHKGT-----IKESRVLAPWITETHFK--ELVPGRLYQVTVSCVS--GELSAQKMAVGRT 593
K IKE IT T + L P Y++ VS V+ G+ + V RT
Sbjct: 359 KSKSQDGPYQIKED------ITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRT 412
Query: 594 FPDKVANLEANNNGRMRS---LVVSWSPPA---------------------GDWEQYRIL 629
A+ N RM S ++V W P G+W+++ +
Sbjct: 413 GEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV- 471
Query: 630 LFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVES--GNLKNSERCQGRT---V 684
+DS++ TVG L+ Y V V+ + G+ S+ Q +T V
Sbjct: 472 --DDSLLT---TVGS-----------LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGV 515
Query: 685 PLAVLQLRVKHANETSLSIMWQTPVAE 711
P + LR + +ETS+++ W P E
Sbjct: 516 PGQPMNLRAEARSETSITLSWSPPRQE 542
Score = 35.8 bits (81), Expect = 0.48
Identities = 65/310 (20%), Positives = 118/310 (38%), Gaps = 28/310 (9%)
Query: 996 IPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHV 1055
+P N + Y+ + G EA Q +++P+ + + + +
Sbjct: 282 MPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITI 341
Query: 1056 TWSGANGDVDQYEIQLLFNDMKVFPPFHLVN--TATEYRFTSLTPGRQYKILVLTIS--- 1110
TW N D Y + + + P+ + T T Y L+P +Y+I V ++
Sbjct: 342 TWDSGNPDPVSYYV-IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIG 400
Query: 1111 -GDVQQSAFIE-GFTVP-SAVKNIHISPNGATDSLTVNW----TPGG---GDVDSYTVSA 1160
G +S G P SA +N+ AT ++ V W P G G YT+
Sbjct: 401 QGPPSESVVTRTGEQAPASAPRNVQARMLSAT-TMIVQWEEPVEPNGLIRGYRVYYTMEP 459
Query: 1161 FRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVS----GSLKNQINV-VGRTVPAS 1215
+ + T L E Y + + + + G L + I V + VP
Sbjct: 460 EHPVGNWQKHNVDDSLLT-TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ 518
Query: 1216 VQGVIADNAYSSYSLIVSWQKAAGVA-ERYDILLLT-ENGILLRNTSEPATTKQHKFEDL 1273
+ A+ A S S+ +SW + +Y++L ++G + T +P T+ + EDL
Sbjct: 519 PMNLRAE-ARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTS--YVVEDL 575
Query: 1274 TPGKKYKIQI 1283
P +Y ++
Sbjct: 576 KPNTEYAFRL 585
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 238 bits (607), Expect = 5e-62
Identities = 246/952 (25%), Positives = 401/952 (42%), Gaps = 112/952 (11%)
Query: 1289 GLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLY---NPDGNLQ 1345
G+ AQ +++P A +TEN+ ++ W + + Y + Y + DG Q
Sbjct: 305 GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQ 364
Query: 1346 ERAQVDPLVQSFSFQNLLQGRMYKMVI--VTHSGELSNESFIFGRT---VPASVSHLRGS 1400
+ + +S L Y++ + V G+ + RT PAS +
Sbjct: 365 IKEDIT--TTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQA 422
Query: 1401 NRNTTDSLWFNWSPA-------SGDFDFYELILYNPNGT-KKENWKDKDLTEWRFQGLVP 1452
+ ++ W G +Y + +P G +K N D LT L+
Sbjct: 423 RMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT--VGSLLE 480
Query: 1453 GRKYVLWVVTHS----GDLSNKVTAESRTA-PSPPSLMSFADIANTSLAITWKGPPDWTD 1507
Y + V+ + G LS+ + +++ P P + + TS+ ++W PP
Sbjct: 481 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS-PPRQES 539
Query: 1508 YNDFELQWLP----RDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSK 1563
+EL + R+ F+P + +V L+P Y F + S ++
Sbjct: 540 IIKYELLFREGDHGREVGRTFDP-----TTSYVVEDLKPNTEYAFRLAARSPQGLGAFT- 593
Query: 1564 PIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDS---------DFDGYSIECRKMDTQE 1614
P+ + +N + T++ SW PD+ ++G +++ T++
Sbjct: 594 PVVRQRTLQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKK 653
Query: 1615 VEFSRKLEKEKSLLNIMMLVPHKRY---LVSIKVQSAGMTSEVVEDSTITMIDRPPPPPP 1671
+ I L PH Y L + G+ V + +++ P P
Sbjct: 654 L--------------ITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP 699
Query: 1672 HIRVNEKDVLISKSSINFTVNCSWFSDTNGAV---KYFTVVV--READGSDELKPEQQHP 1726
+ D I + D V YF V+V R++ G L P P
Sbjct: 700 K---PDADGFIMV----------YLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGS-P 745
Query: 1727 LPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQK--- 1783
LE R+ + + S+ E P + A L P QK
Sbjct: 746 EDMDLEELIQDISRLQRRSLRHSRQLEVPRPY-------IAARFSVLPPTFHPGDQKQYG 798
Query: 1784 -FCDGPLKPHTAYRISIRAFTQLFDEDL--KEFTKPLYSDTFFSLPITTESEPLFGAIEG 1840
F + L+P Y + + A Q + F+ P D PI E L I
Sbjct: 799 GFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGP 858
Query: 1841 VSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDR----------PLSVHLNLG 1890
V A +F+I + V+A+L+ + K R+ R + P+ +
Sbjct: 859 VLAVVFIICI---VIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINF 915
Query: 1891 QKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNR 1950
Q + PI I H +L+A+ + LS+EYE + D G+ + + + L N+ KNR
Sbjct: 916 QTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESI-DPGQQFTWEHSNLEVNKPKNR 974
Query: 1951 YNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWE 2010
Y N++ YD +RV L ++ SDYINA+Y+ G + YI TQGPLP T DFW+MVWE
Sbjct: 975 YANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWE 1034
Query: 2011 QNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEE 2070
Q IVM+T+ EK R+KCD YWP ++ + YG + + +L L + +R F + +
Sbjct: 1035 QRSATIVMMTRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSL-HKN 1092
Query: 2071 QLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTG 2130
R +R F +T WPDHGVPE + F+R V+ P AGP VVHCSAGVGRTG
Sbjct: 1093 GSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC--NPPDAGPIVVHCSAGVGRTG 1150
Query: 2131 TFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL 2182
FI +D +L+++ + +VD+YG V +R R +MVQTE QY ++H+ + + +
Sbjct: 1151 CFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1202
Score = 195 bits (495), Expect = 5e-49
Identities = 103/243 (42%), Positives = 148/243 (60%), Gaps = 2/243 (0%)
Query: 1940 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1999
A LP N+ KNR NI+PY++TRV L + SDYINAS+I G ++ YI TQGPL
Sbjct: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312
Query: 2000 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 2059
T +DFW+M+WE N +VM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1313 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1371
Query: 2060 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 2119
+REFK+ + + R +R F +T WP+ GVP++ + I F+ V + GP
Sbjct: 1372 ILREFKVT-DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1430
Query: 2120 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 2179
VHCSAGVGRTG FI L +L+++ + VDI+ V LR R MVQTE +Y + +Q
Sbjct: 1431 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL 1490
Query: 2180 DVL 2182
+ L
Sbjct: 1491 EYL 1493
Score = 43.1 bits (100), Expect = 0.003
Identities = 59/306 (19%), Positives = 117/306 (38%), Gaps = 31/306 (10%)
Query: 1094 TSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDV 1153
T + Y + ++ G ++ A I ++P A ++ N AT S+T+ W G D
Sbjct: 288 TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTAT-SITITWDSGNPDP 346
Query: 1154 DSYTVSAFRHSQKVDSQTIPKHV--FEHTFHRLEAGEQYQIMIASVSG-----SLKNQIN 1206
SY V ++ + I + + ++ L +Y+I +++V+ ++ +
Sbjct: 347 VSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVT 406
Query: 1207 VVGRTVPASVQGVIADNAYSSYSLIVSWQKAA---GVAERYDILLLTENGILLRNTSEPA 1263
G PAS + S+ ++IV W++ G+ Y + E + N
Sbjct: 407 RTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGN----- 461
Query: 1264 TTKQHKFED--------LTPGKKYKIQIL---TVSGGLFSKEAQTEGRT-VPAAVTDLRI 1311
++H +D L + Y +++L +V G S Q + + VP +LR
Sbjct: 462 -WQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRA 520
Query: 1312 TENSTRHLSFRWTASEGE-LSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKM 1370
S ++ W+ E + Y + D + DP S+ ++L Y
Sbjct: 521 EARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDP-TTSYVVEDLKPNTEYAF 579
Query: 1371 VIVTHS 1376
+ S
Sbjct: 580 RLAARS 585
Score = 36.6 bits (83), Expect = 0.28
Identities = 63/267 (23%), Positives = 101/267 (37%), Gaps = 63/267 (23%)
Query: 484 YNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRP-PGNVDSYNITL 542
Y M+ ++ V++ P VT + + TS+ + W P V Y I
Sbjct: 296 YTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVT-ENTATSITITWDSGNPDPVSYYVIEY 354
Query: 543 SHKGT-----IKESRVLAPWITETHFK--ELVPGRLYQVTVSCVS--GELSAQKMAVGRT 593
K IKE IT T + L P Y++ VS V+ G+ + V RT
Sbjct: 355 KSKSQDGPYQIKED------ITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRT 408
Query: 594 FPDKVANLEANNNGRMRS---LVVSWSPPA---------------------GDWEQYRIL 629
A+ N RM S ++V W P G+W+++ +
Sbjct: 409 GEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV- 467
Query: 630 LFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVES--GNLKNSERCQGRT---V 684
+DS++ TVG L+ Y V V+ + G+ S+ Q +T V
Sbjct: 468 --DDSLLT---TVGS-----------LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGV 511
Query: 685 PLAVLQLRVKHANETSLSIMWQTPVAE 711
P + LR + +ETS+++ W P E
Sbjct: 512 PGQPMNLRAEARSETSITLSWSPPRQE 538
Score = 35.8 bits (81), Expect = 0.48
Identities = 65/310 (20%), Positives = 118/310 (38%), Gaps = 28/310 (9%)
Query: 996 IPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHV 1055
+P N + Y+ + G EA Q +++P+ + + + +
Sbjct: 278 MPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITI 337
Query: 1056 TWSGANGDVDQYEIQLLFNDMKVFPPFHLVN--TATEYRFTSLTPGRQYKILVLTIS--- 1110
TW N D Y + + + P+ + T T Y L+P +Y+I V ++
Sbjct: 338 TWDSGNPDPVSYYV-IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIG 396
Query: 1111 -GDVQQSAFIE-GFTVP-SAVKNIHISPNGATDSLTVNW----TPGG---GDVDSYTVSA 1160
G +S G P SA +N+ AT ++ V W P G G YT+
Sbjct: 397 QGPPSESVVTRTGEQAPASAPRNVQARMLSAT-TMIVQWEEPVEPNGLIRGYRVYYTMEP 455
Query: 1161 FRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVS----GSLKNQINV-VGRTVPAS 1215
+ + T L E Y + + + + G L + I V + VP
Sbjct: 456 EHPVGNWQKHNVDDSLLT-TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ 514
Query: 1216 VQGVIADNAYSSYSLIVSWQKAAGVA-ERYDILLLT-ENGILLRNTSEPATTKQHKFEDL 1273
+ A+ A S S+ +SW + +Y++L ++G + T +P T+ + EDL
Sbjct: 515 PMNLRAE-ARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTS--YVVEDL 571
Query: 1274 TPGKKYKIQI 1283
P +Y ++
Sbjct: 572 KPNTEYAFRL 581
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 238 bits (607), Expect = 5e-62
Identities = 149/454 (32%), Positives = 223/454 (49%), Gaps = 61/454 (13%)
Query: 1780 TQQKFCDGPLKPHTAYRISIRAFTQLFDED----LKEFTKPLYSDTFFSLPITTESEPLF 1835
T Q F + PL P Y I +A + + E ++ TK ++ +P +
Sbjct: 692 TYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRV 751
Query: 1836 GAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARL-------------------S 1876
I G+SAG+ + +L+ VV L++ + K++ R+ +
Sbjct: 752 VKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQST 811
Query: 1877 IRRDRPLSVHL-------------NLGQKGNRKTSCP-------------------IKIN 1904
+ + PLS+ + + +R P I++
Sbjct: 812 LHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVA 871
Query: 1905 QFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKL 1964
H ++ +Y +EYE + G++ S D+A +NR KNRY NI+ YD +RV L
Sbjct: 872 DLLQHINLMKTSDSYGFKEEYESFFE-GQSASWDVAKKDQNRAKNRYGNIIAYDHSRVIL 930
Query: 1965 SNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVE 2024
V+DDP SDYINA+YI G YI TQGP+ T DFW+M+W++ IVMVT VE
Sbjct: 931 QPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVE 990
Query: 2025 KGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYT 2084
GRVKC YWP D + YGD + + L E+ +R F + + R ++ FH+T
Sbjct: 991 VGRVKCYKYWPDDTE--VYGDFKVTCVEMEPLAEYVVRTFTL-ERRGYNEIREVKQFHFT 1047
Query: 2085 VWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDS 2144
WPDHGVP L+ F+R V+ ++ P AGP VVHCSAG GRTG +I +D +L +
Sbjct: 1048 GWPDHGVPYHATGLLSFIRRVK--LSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAER 1105
Query: 2145 KDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 2178
+ VDIY V LR R++MVQTE QY+++H +
Sbjct: 1106 EGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAI 1139
Score = 132 bits (331), Expect = 5e-30
Identities = 87/293 (29%), Positives = 153/293 (52%), Gaps = 13/293 (4%)
Query: 1899 CPIKINQFEGHFMKLQADSNYLLSKEYEELKDVG---RNQSCDIALLPENRGKNRYNNIL 1955
C K F+ + Q +S++L E++ L V + + C IA LP N KNR+ ++L
Sbjct: 1153 CEFKAAYFDMIRIDSQTNSSHL-KDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDML 1211
Query: 1956 PYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN 2015
P D L +D + S+YINA+ + +IVTQ PLP T DFW++V++ +
Sbjct: 1212 PPDRCLPFLITIDGES-SNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTS 1270
Query: 2016 IVMVTQC-VEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICG-EEQLD 2073
IVM+ + + +G C YWP ++ L YG + ++ +S S+ + R F+IC +
Sbjct: 1271 IVMLNEVDLSQG---CPQYWP-EEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQE 1326
Query: 2074 AHRLIRHFHYTVWPDHG-VPETTQSLIQFVRTVRDYINR-SPGAGPTVVHCSAGVGRTGT 2131
+ +++ F Y W H VP + +S ++ + V + G G T++HC G GR+G
Sbjct: 1327 GYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGM 1386
Query: 2132 FIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRA 2184
F A+ +++ + ++ VD++ AV LR + +MV+ QY + + + L +
Sbjct: 1387 FCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 235 bits (600), Expect = 3e-61
Identities = 125/280 (44%), Positives = 167/280 (59%), Gaps = 10/280 (3%)
Query: 1901 IKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDAT 1960
I++ H +++ Y +EYE + G++ D A ENR KNRY NI+ YD +
Sbjct: 880 IRVADLLQHITQMKCAEGYGFKEEYESFFE-GQSAPWDSAKKDENRMKNRYGNIIAYDHS 938
Query: 1961 RVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVT 2020
RV+L ++ D SDYIN +YI G + YI TQGP+ T DFW+MVW +N +I+MVT
Sbjct: 939 RVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT 998
Query: 2021 QCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH--RLI 2078
VE GRVKC YWP D + Y D+ + ++ +L E+ IR F + E+ H R I
Sbjct: 999 NLVEVGRVKCCKYWPDDTE--IYKDIKVTLIETELLAEYVIRTFAV---EKRGVHEIREI 1053
Query: 2079 RHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRI 2138
R FH+T WPDHGVP L+ FVR V+ P AGP VVHCSAG GRTG FI +D +
Sbjct: 1054 RQFHFTGWPDHGVPYHATGLLGFVRQVKS--KSPPSAGPLVVHCSAGAGRTGCFIVIDIM 1111
Query: 2139 LQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 2178
L + + VDIY V +LR RV+MVQTE QYV++H +
Sbjct: 1112 LDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAI 1151
Score = 127 bits (318), Expect = 2e-28
Identities = 81/255 (31%), Positives = 138/255 (54%), Gaps = 7/255 (2%)
Query: 1933 RNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIV 1992
R + C IALLP N KNR +ILP D L +D + S+YINA+ + +IV
Sbjct: 1201 RVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAALMDSYKQPSAFIV 1259
Query: 1993 TQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLS 2052
TQ PLP T DFW++V + + ++VM+ V+ ++ C YWP + +G + ++ +S
Sbjct: 1260 TQHPLPNTVKDFWRLVLDYHCTSVVMLND-VDPAQL-CPQYWP-ENGVHRHGPIQVEFVS 1316
Query: 2053 ESVLPEWTIREFKICGEEQ-LDAHRLIRHFHYTVWPDH-GVPETTQSLIQFVRTVRDYIN 2110
+ + R F+I + D +R+++ F + WP + P + +S ++ +R V +
Sbjct: 1317 ADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQE 1376
Query: 2111 R-SPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTEC 2169
+ G G TVVHC G GR+GTF A+ + + L + +VD++ AV LR ++ +MV
Sbjct: 1377 EYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLD 1436
Query: 2170 QYVYLHQCVRDVLRA 2184
QY + ++ + L +
Sbjct: 1437 QYKFCYEVALEYLNS 1451
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 235 bits (600), Expect = 3e-61
Identities = 125/280 (44%), Positives = 167/280 (59%), Gaps = 10/280 (3%)
Query: 1901 IKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDAT 1960
I++ H +++ Y +EYE + G++ D A ENR KNRY NI+ YD +
Sbjct: 893 IRVADLLQHITQMKCAEGYGFKEEYESFFE-GQSAPWDSAKKDENRMKNRYGNIIAYDHS 951
Query: 1961 RVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVT 2020
RV+L ++ D SDYIN +YI G + YI TQGP+ T DFW+MVW +N +I+MVT
Sbjct: 952 RVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT 1011
Query: 2021 QCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH--RLI 2078
VE GRVKC YWP D + Y D+ + ++ +L E+ IR F + E+ H R I
Sbjct: 1012 NLVEVGRVKCCKYWPDDTE--IYKDIKVTLIETELLAEYVIRTFAV---EKRGVHEIREI 1066
Query: 2079 RHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRI 2138
R FH+T WPDHGVP L+ FVR V+ P AGP VVHCSAG GRTG FI +D +
Sbjct: 1067 RQFHFTGWPDHGVPYHATGLLGFVRQVKS--KSPPSAGPLVVHCSAGAGRTGCFIVIDIM 1124
Query: 2139 LQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 2178
L + + VDIY V +LR RV+MVQTE QYV++H +
Sbjct: 1125 LDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAI 1164
Score = 127 bits (318), Expect = 2e-28
Identities = 81/255 (31%), Positives = 138/255 (54%), Gaps = 7/255 (2%)
Query: 1933 RNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIV 1992
R + C IALLP N KNR +ILP D L +D + S+YINA+ + +IV
Sbjct: 1214 RVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAALMDSYKQPSAFIV 1272
Query: 1993 TQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLS 2052
TQ PLP T DFW++V + + ++VM+ V+ ++ C YWP + +G + ++ +S
Sbjct: 1273 TQHPLPNTVKDFWRLVLDYHCTSVVMLND-VDPAQL-CPQYWP-ENGVHRHGPIQVEFVS 1329
Query: 2053 ESVLPEWTIREFKICGEEQ-LDAHRLIRHFHYTVWPDH-GVPETTQSLIQFVRTVRDYIN 2110
+ + R F+I + D +R+++ F + WP + P + +S ++ +R V +
Sbjct: 1330 ADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQE 1389
Query: 2111 R-SPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTEC 2169
+ G G TVVHC G GR+GTF A+ + + L + +VD++ AV LR ++ +MV
Sbjct: 1390 EYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLD 1449
Query: 2170 QYVYLHQCVRDVLRA 2184
QY + ++ + L +
Sbjct: 1450 QYKFCYEVALEYLNS 1464
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 233 bits (595), Expect = 1e-60
Identities = 133/356 (37%), Positives = 199/356 (55%), Gaps = 10/356 (2%)
Query: 1829 TESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDR---PLSV 1885
++ P+ + +S+ L +I ++ V+ +L ++ G S RLS R P SV
Sbjct: 138 SDETPIIAVMVALSS-LLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSV 196
Query: 1886 HLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPEN 1945
L + P+ +++ E + AD N L +E+ L +C+ A EN
Sbjct: 197 PLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEEN 256
Query: 1946 RGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFW 2005
+ KNRY NILPYD +RV L+ V+ P SDYINAS+I G + ++I QGP T +DFW
Sbjct: 257 KEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFW 316
Query: 2006 KMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREF- 2064
+M+WEQN IVMVT E+ KC YWP DQ YG++ + + +VL ++T+R+F
Sbjct: 317 RMIWEQNTATIVMVTNLKERKECKCAQYWP-DQGCWTYGNIRVSVEDVTVLVDYTVRKFC 375
Query: 2065 --KICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHC 2122
++ RLI FH+T WPD GVP T +++F++ V+ AG VVHC
Sbjct: 376 IQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVK--ACNPQYAGAIVVHC 433
Query: 2123 SAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 2178
SAGVGRTGTF+ +D +L + ++ VD+YG V +R R MVQT+ QYV+++Q +
Sbjct: 434 SAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQAL 489
Score = 190 bits (483), Expect = 1e-47
Identities = 102/289 (35%), Positives = 165/289 (57%), Gaps = 8/289 (2%)
Query: 1901 IKINQFEGH----FMKLQADSNYLLSKEYEELKDVG-RNQSCDIALLPENRGKNRYNNIL 1955
+++ E H + K+ SN L +E+++L + +N LP N KNR I+
Sbjct: 500 LEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQII 559
Query: 1956 PYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN 2015
PY+ RV + + +DY+NAS+I G + YI +QGPL T +DFW+M+WE +
Sbjct: 560 PYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCS 619
Query: 2016 IVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH 2075
IVM+T+ E+G+ KC YWP+D + YGD+ +++ E +T+R+ + + +
Sbjct: 620 IVMLTELEERGQEKCAQYWPSD-GLVSYGDITVELKKEEECESYTVRDLLVTNTRE-NKS 677
Query: 2076 RLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIAL 2135
R IR FH+ WP+ G+P + +I + V+ +S G P VHCSAG GRTGTF AL
Sbjct: 678 RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQS-GNHPITVHCSAGAGRTGTFCAL 736
Query: 2136 DRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRA 2184
+L+++ ++ +D++ V LRL R HMVQT QY + ++ V++ + A
Sbjct: 737 STVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA 785
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 233 bits (595), Expect = 1e-60
Identities = 133/356 (37%), Positives = 199/356 (55%), Gaps = 10/356 (2%)
Query: 1829 TESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDR---PLSV 1885
++ P+ + +S+ L +I ++ V+ +L ++ G S RLS R P SV
Sbjct: 138 SDETPIIAVMVALSS-LLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSV 196
Query: 1886 HLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPEN 1945
L + P+ +++ E + AD N L +E+ L +C+ A EN
Sbjct: 197 PLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEEN 256
Query: 1946 RGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFW 2005
+ KNRY NILPYD +RV L+ V+ P SDYINAS+I G + ++I QGP T +DFW
Sbjct: 257 KEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFW 316
Query: 2006 KMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREF- 2064
+M+WEQN IVMVT E+ KC YWP DQ YG++ + + +VL ++T+R+F
Sbjct: 317 RMIWEQNTATIVMVTNLKERKECKCAQYWP-DQGCWTYGNIRVSVEDVTVLVDYTVRKFC 375
Query: 2065 --KICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHC 2122
++ RLI FH+T WPD GVP T +++F++ V+ AG VVHC
Sbjct: 376 IQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVK--ACNPQYAGAIVVHC 433
Query: 2123 SAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 2178
SAGVGRTGTF+ +D +L + ++ VD+YG V +R R MVQT+ QYV+++Q +
Sbjct: 434 SAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQAL 489
Score = 190 bits (483), Expect = 1e-47
Identities = 102/289 (35%), Positives = 165/289 (57%), Gaps = 8/289 (2%)
Query: 1901 IKINQFEGH----FMKLQADSNYLLSKEYEELKDVG-RNQSCDIALLPENRGKNRYNNIL 1955
+++ E H + K+ SN L +E+++L + +N LP N KNR I+
Sbjct: 500 LEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQII 559
Query: 1956 PYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN 2015
PY+ RV + + +DY+NAS+I G + YI +QGPL T +DFW+M+WE +
Sbjct: 560 PYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCS 619
Query: 2016 IVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH 2075
IVM+T+ E+G+ KC YWP+D + YGD+ +++ E +T+R+ + + +
Sbjct: 620 IVMLTELEERGQEKCAQYWPSD-GLVSYGDITVELKKEEECESYTVRDLLVTNTRE-NKS 677
Query: 2076 RLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIAL 2135
R IR FH+ WP+ G+P + +I + V+ +S G P VHCSAG GRTGTF AL
Sbjct: 678 RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQS-GNHPITVHCSAGAGRTGTFCAL 736
Query: 2136 DRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRA 2184
+L+++ ++ +D++ V LRL R HMVQT QY + ++ V++ + A
Sbjct: 737 STVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA 785
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 233 bits (594), Expect = 2e-60
Identities = 133/355 (37%), Positives = 198/355 (55%), Gaps = 10/355 (2%)
Query: 1830 ESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDR---PLSVH 1886
+ P+ + +S+ L +I ++ V+ +L ++ G S RLS R P SV
Sbjct: 148 DETPIIAVMVALSS-LLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVP 206
Query: 1887 LNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENR 1946
L + P+ +++ E + AD N L +E+ L +C+ A EN+
Sbjct: 207 LLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENK 266
Query: 1947 GKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWK 2006
KNRY NILPYD +RV L+ V+ P SDYINAS+I G + ++I QGP T +DFW+
Sbjct: 267 EKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWR 326
Query: 2007 MVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREF-- 2064
M+WEQN IVMVT E+ KC YWP DQ YG++ + + +VL ++T+R+F
Sbjct: 327 MIWEQNTATIVMVTNLKERKECKCAQYWP-DQGCWTYGNIRVSVEDVTVLVDYTVRKFCI 385
Query: 2065 -KICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCS 2123
++ RLI FH+T WPD GVP T +++F++ V+ AG VVHCS
Sbjct: 386 QQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVK--ACNPQYAGAIVVHCS 443
Query: 2124 AGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 2178
AGVGRTGTF+ +D +L + ++ VD+YG V +R R MVQT+ QYV+++Q +
Sbjct: 444 AGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQAL 498
Score = 190 bits (483), Expect = 1e-47
Identities = 102/289 (35%), Positives = 165/289 (57%), Gaps = 8/289 (2%)
Query: 1901 IKINQFEGH----FMKLQADSNYLLSKEYEELKDVG-RNQSCDIALLPENRGKNRYNNIL 1955
+++ E H + K+ SN L +E+++L + +N LP N KNR I+
Sbjct: 509 LEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQII 568
Query: 1956 PYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN 2015
PY+ RV + + +DY+NAS+I G + YI +QGPL T +DFW+M+WE +
Sbjct: 569 PYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCS 628
Query: 2016 IVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH 2075
IVM+T+ E+G+ KC YWP+D + YGD+ +++ E +T+R+ + + +
Sbjct: 629 IVMLTELEERGQEKCAQYWPSD-GLVSYGDITVELKKEEECESYTVRDLLVTNTRE-NKS 686
Query: 2076 RLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIAL 2135
R IR FH+ WP+ G+P + +I + V+ +S G P VHCSAG GRTGTF AL
Sbjct: 687 RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQS-GNHPITVHCSAGAGRTGTFCAL 745
Query: 2136 DRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRA 2184
+L+++ ++ +D++ V LRL R HMVQT QY + ++ V++ + A
Sbjct: 746 STVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA 794
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 233 bits (593), Expect = 2e-60
Identities = 130/304 (42%), Positives = 184/304 (60%), Gaps = 23/304 (7%)
Query: 1901 IKINQFEGHFMKLQADSNYLLSKEYEELKDVGRN-QSCDIAL--------LPENRGKNRY 1951
I I F H L A S + ++E+E LK+ + QSC + L P+N+ KNRY
Sbjct: 1699 IPIKHFPKHVADLHASSGF--TEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRY 1756
Query: 1952 NNILPYDATRVKLSNV--DDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVW 2009
NI+ YD +RVKL+ + D +DYINA+Y+ G N + YI QGPL T +DFW+M+W
Sbjct: 1757 INIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIW 1816
Query: 2010 EQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREF----- 2064
E NV IVM+T VEKGR KCD YWPAD S YG+ ++ S VL +T+R F
Sbjct: 1817 EHNVEVIVMITNLVEKGRRKCDQYWPAD-GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNT 1875
Query: 2065 --KICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHC 2122
K ++ + R++ +HYT WPD GVPE + ++ FVR Y R GP VVHC
Sbjct: 1876 KIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAA-YAKRH-AVGPVVVHC 1933
Query: 2123 SAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL 2182
SAGVGRTGT+I LD +LQQ+ + +V+I+G + +R R ++VQTE QYV++H + + +
Sbjct: 1934 SAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI 1993
Query: 2183 RARK 2186
+++
Sbjct: 1994 LSKE 1997
Score = 115 bits (288), Expect = 5e-25
Identities = 87/281 (30%), Positives = 140/281 (49%), Gaps = 19/281 (6%)
Query: 1921 LSKEYEELKDVGRNQSCDIALLPE-NRGKNRYNNILPYDATRVKLSNVDDDPCSDYINAS 1979
L K+++ L QS A L + NR KNR ++I+P + +RV +S++ + +DYINAS
Sbjct: 2023 LEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEG-TDYINAS 2081
Query: 1980 YIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQD 2039
YI G E+I+TQ PL T DFW+M+W+ N +VM+ + YWP +
Sbjct: 2082 YIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKDE 2140
Query: 2040 SLYYGDLILQMLSE-----SVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVP-E 2093
+ + +++E S + I++F I Q D +RHF WP+ P
Sbjct: 2141 PINCESFKVTLMAEEHKCLSNEEKLIIQDF-ILEATQDDYVLEVRHFQCPKWPNPDSPIS 2199
Query: 2094 TTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGA 2153
T LI ++ + NR GP +VH G GTF AL ++ QL+ ++SVD+Y
Sbjct: 2200 KTFELISVIK--EEAANRD---GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQV 2254
Query: 2154 VHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENP 2194
+ L R + QY +L++ + ++ R ++ENP
Sbjct: 2255 AKMINLMRPGVFADIEQYQFLYKVILSLVSTR----QEENP 2291
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,245,234
Number of Sequences: 37866
Number of extensions: 3889214
Number of successful extensions: 14385
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 132
Number of HSP's successfully gapped in prelim test: 96
Number of HSP's that attempted gapping in prelim test: 10911
Number of HSP's gapped (non-prelim): 1626
length of query: 2215
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2097
effective length of database: 13,779,330
effective search space: 28895255010
effective search space used: 28895255010
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.