Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 157952213
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157952213 protein tyrosine phosphatase, receptor type, B
isoform b precursor [Homo sapiens]
(1997 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157952213 protein tyrosine phosphatase, receptor type, B isof... 4043 0.0
gi|157952215 protein tyrosine phosphatase, receptor type, B isof... 4009 0.0
gi|148728162 protein tyrosine phosphatase, receptor type, J isof... 428 e-119
gi|4506323 receptor-type protein tyrosine phosphatase O isoform ... 306 2e-82
gi|13677220 receptor-type protein tyrosine phosphatase O isoform... 303 1e-81
gi|13677216 receptor-type protein tyrosine phosphatase O isoform... 303 1e-81
gi|13677222 receptor-type protein tyrosine phosphatase O isoform... 297 8e-80
gi|13677218 receptor-type protein tyrosine phosphatase O isoform... 297 8e-80
gi|13677214 receptor-type protein tyrosine phosphatase O isoform... 297 8e-80
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 296 1e-79
gi|241896926 protein tyrosine phosphatase, receptor type, H isof... 280 8e-75
gi|241896924 protein tyrosine phosphatase, receptor type, H isof... 280 8e-75
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 252 2e-66
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 251 7e-66
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 246 2e-64
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 246 2e-64
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 246 2e-64
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 245 4e-64
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 245 4e-64
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 243 1e-63
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 243 1e-63
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 238 4e-62
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 238 4e-62
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 238 4e-62
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 235 3e-61
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 235 3e-61
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 233 1e-60
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 233 1e-60
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 233 1e-60
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 233 2e-60
>gi|157952213 protein tyrosine phosphatase, receptor type, B isoform b
precursor [Homo sapiens]
Length = 1997
Score = 4043 bits (10486), Expect = 0.0
Identities = 1997/1997 (100%), Positives = 1997/1997 (100%)
Query: 1 MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSS 60
MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSS
Sbjct: 1 MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSS 60
Query: 61 DTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSK 120
DTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSK
Sbjct: 61 DTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSK 120
Query: 121 EKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYN 180
EKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYN
Sbjct: 121 EKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYN 180
Query: 181 IAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKG 240
IAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKG
Sbjct: 181 IAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKG 240
Query: 241 ILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTND 300
ILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTND
Sbjct: 241 ILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTND 300
Query: 301 GSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSC 360
GSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSC
Sbjct: 301 GSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSC 360
Query: 361 VSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLL 420
VSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLL
Sbjct: 361 VSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLL 420
Query: 421 NITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANE 480
NITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANE
Sbjct: 421 NITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANE 480
Query: 481 TSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISG 540
TSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISG
Sbjct: 481 TSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISG 540
Query: 541 DLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNES 600
DLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNES
Sbjct: 541 DLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNES 600
Query: 601 ISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYL 660
ISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYL
Sbjct: 601 ISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYL 660
Query: 661 SVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYE 720
SVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYE
Sbjct: 661 SVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYE 720
Query: 721 NHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPK 780
NHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPK
Sbjct: 721 NHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPK 780
Query: 781 SENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWS 840
SENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWS
Sbjct: 781 SENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWS 840
Query: 841 GANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAF 900
GANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAF
Sbjct: 841 GANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAF 900
Query: 901 IEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFE 960
IEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFE
Sbjct: 901 IEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFE 960
Query: 961 HTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAA 1020
HTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAA
Sbjct: 961 HTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAA 1020
Query: 1021 GVAERYDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTE 1080
GVAERYDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTE
Sbjct: 1021 GVAERYDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTE 1080
Query: 1081 GRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFS 1140
GRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFS
Sbjct: 1081 GRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFS 1140
Query: 1141 FQNLLQGRMYKMVIVTHSGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGD 1200
FQNLLQGRMYKMVIVTHSGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGD
Sbjct: 1141 FQNLLQGRMYKMVIVTHSGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGD 1200
Query: 1201 FDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTA 1260
FDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTA
Sbjct: 1201 FDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTA 1260
Query: 1261 PSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVY 1320
PSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVY
Sbjct: 1261 PSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVY 1320
Query: 1321 GLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDS 1380
GLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDS
Sbjct: 1321 GLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDS 1380
Query: 1381 DFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDS 1440
DFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDS
Sbjct: 1381 DFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDS 1440
Query: 1441 TITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDE 1500
TITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDE
Sbjct: 1441 TITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDE 1500
Query: 1501 LKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCD 1560
LKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCD
Sbjct: 1501 LKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCD 1560
Query: 1561 PTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAI 1620
PTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAI
Sbjct: 1561 PTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAI 1620
Query: 1621 EGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTS 1680
EGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTS
Sbjct: 1621 EGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTS 1680
Query: 1681 CPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYD 1740
CPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYD
Sbjct: 1681 CPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYD 1740
Query: 1741 ATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVM 1800
ATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVM
Sbjct: 1741 ATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVM 1800
Query: 1801 VTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLI 1860
VTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLI
Sbjct: 1801 VTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLI 1860
Query: 1861 RHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRI 1920
RHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRI
Sbjct: 1861 RHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRI 1920
Query: 1921 LQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPI 1980
LQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPI
Sbjct: 1921 LQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPI 1980
Query: 1981 YENVNPEYHRDPVYSRH 1997
YENVNPEYHRDPVYSRH
Sbjct: 1981 YENVNPEYHRDPVYSRH 1997
>gi|157952215 protein tyrosine phosphatase, receptor type, B isoform a
[Homo sapiens]
Length = 2215
Score = 4009 bits (10398), Expect = 0.0
Identities = 1979/1980 (99%), Positives = 1980/1980 (100%)
Query: 18 QTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTT 77
+TGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTT
Sbjct: 236 ETGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTT 295
Query: 78 YGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSG 137
YGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSG
Sbjct: 296 YGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSG 355
Query: 138 KVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYT 197
KVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYT
Sbjct: 356 KVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYT 415
Query: 198 NGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAF 257
NGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAF
Sbjct: 416 NGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGILVHGGVVDKHATSYAF 475
Query: 258 HGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNV 317
HGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNV
Sbjct: 476 HGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNV 535
Query: 318 DSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFP 377
DSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFP
Sbjct: 536 DSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFP 595
Query: 378 DKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTG 437
DKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTG
Sbjct: 596 DKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTG 655
Query: 438 LVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKY 497
LVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKY
Sbjct: 656 LVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKY 715
Query: 498 IISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQV 557
IISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQV
Sbjct: 716 IISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQV 775
Query: 558 TDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGS 617
TDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGS
Sbjct: 776 TDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGS 835
Query: 618 LYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVT 677
LYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVT
Sbjct: 836 LYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVT 895
Query: 678 LSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGV 737
LSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGV
Sbjct: 896 LSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQERTVPDKVQGV 955
Query: 738 SVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYS 797
SVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYS
Sbjct: 956 SVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYS 1015
Query: 798 VTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFND 857
VTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFND
Sbjct: 1016 VTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFND 1075
Query: 858 MKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISP 917
MKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISP
Sbjct: 1076 MKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISP 1135
Query: 918 NGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIA 977
NGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIA
Sbjct: 1136 NGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIA 1195
Query: 978 SVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGIL 1037
SVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGIL
Sbjct: 1196 SVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGIL 1255
Query: 1038 LRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENS 1097
LRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENS
Sbjct: 1256 LRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENS 1315
Query: 1098 TRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTH 1157
TRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTH
Sbjct: 1316 TRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTH 1375
Query: 1158 SGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKE 1217
SGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKE
Sbjct: 1376 SGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKE 1435
Query: 1218 NWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSL 1277
NWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSL
Sbjct: 1436 NWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSL 1495
Query: 1278 AITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSG 1337
AITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSG
Sbjct: 1496 AITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSG 1555
Query: 1338 DSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEV 1397
DSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEV
Sbjct: 1556 DSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEV 1615
Query: 1398 EFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRV 1457
EFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRV
Sbjct: 1616 EFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRV 1675
Query: 1458 NEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRH 1517
NEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRH
Sbjct: 1676 NEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRH 1735
Query: 1518 NASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAY 1577
NASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAY
Sbjct: 1736 NASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAY 1795
Query: 1578 RISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSAGLFLIGMLVAVV 1637
RISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSAGLFLIGMLVAVV
Sbjct: 1796 RISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSAGLFLIGMLVAVV 1855
Query: 1638 ALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQA 1697
ALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQA
Sbjct: 1856 ALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQA 1915
Query: 1698 DSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDY 1757
DSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDY
Sbjct: 1916 DSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDY 1975
Query: 1758 INASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWP 1817
INASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWP
Sbjct: 1976 INASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWP 2035
Query: 1818 ADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETT 1877
ADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETT
Sbjct: 2036 ADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETT 2095
Query: 1878 QSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVH 1937
QSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVH
Sbjct: 2096 QSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVH 2155
Query: 1938 DLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRDPVYSRH 1997
DLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRDPVYSRH
Sbjct: 2156 DLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRDPVYSRH 2215
>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
precursor [Homo sapiens]
Length = 1337
Score = 428 bits (1101), Expect = e-119
Identities = 371/1290 (28%), Positives = 579/1290 (44%), Gaps = 154/1290 (11%)
Query: 750 VSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEA 809
++W Y+ +K+K +T ++ + C L P Y ++T G
Sbjct: 137 LTWKSNDTAASEYKYVVKHKMENEKTITVVH-QPWCNITGLRPATSYVFSITPGIGN--- 192
Query: 810 NEQGNGRTI-----PEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPF 864
G+ R I P PV DL + ++WS NG ++L +
Sbjct: 193 ETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTAS---CRVLLESIGSHEEL 249
Query: 865 HLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSL 924
++ + + L PG QY I + + K + G D+
Sbjct: 250 -TQDSRLQVNISGLKPGVQYNINPYLLQSN--------------KTKGDPLGTEGGLDAS 294
Query: 925 TVNWTPGGGDV----DSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIAS-- 978
+ G D V S S+ E LE G +Y + S
Sbjct: 295 NTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDT-----EVLLVGLEPGTRYNATVYSQA 349
Query: 979 VSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAER---YDILLLTENG 1035
+G+ + RT V V A N S+ SL + W+ + + Y I + E
Sbjct: 350 ANGTEGQPQAIEFRTNAIQVFDVTAVNI-SATSLTLIWKVSDNESSSNYTYKIHVAGETD 408
Query: 1036 ILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITE 1095
N SEP L Y I + V G + + T P V+D R+T
Sbjct: 409 SSNLNVSEPRAV----IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTV 464
Query: 1096 NSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIV 1155
ST + W++ + E +I +G R ++ QS L G Y IV
Sbjct: 465 VSTTEIGLAWSSHDAESFQMHI---TQEGAGNSRVEITTN-QSIIIGGLFPGTKYCFEIV 520
Query: 1156 TH--SGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDF-YELILYNPN 1212
+G + RTVP++V + TT+ +W +W G ++ Y L++ + +
Sbjct: 521 PKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTE-MWLDWKSPDGASEYVYHLVIESKH 579
Query: 1213 GTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAP-SPPSLMSFAD 1271
G+ + DK +T QGL+PG L+ +T S ++ + + TA + PS +S D
Sbjct: 580 GSNHTSTYDKAIT---LQGLIPG---TLYNITISPEVDHVWGDPNSTAQYTRPSNVSNID 633
Query: 1272 IANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYG---------- 1321
++ + A T W +++D + + N + ++V
Sbjct: 634 VSTNTTAATLS----WQNFDDASPTY---SYCLLIEKAGNSSNATQVVTDIGITDATVTE 686
Query: 1322 LRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRP-QNSTAIACSWIPPDS 1380
L PG SY + GD K+ +P S T P + + C A+ W P
Sbjct: 687 LIPGSSYTVEIFAQVGDGIKSL-EPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPG 745
Query: 1381 DFDGYSIECRK--------MDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGM 1432
G+ +E +++ E + E + LN Y +SI S G
Sbjct: 746 ANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFST-----SYNISITTVSCGK 800
Query: 1433 TSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVV 1492
+ ++ T I PPPP + +S +S+ V S F ++G +K + V++
Sbjct: 801 MAAPTRNTCTTGITDPPPPDGSPNITS----VSHNSVK--VKFSGFEASHGPIKAYAVIL 854
Query: 1493 READGSDELKPEQQHPLPSYLEYRHNASIRVYQTNY--FASKCAENPNSNSKS----FNI 1546
+ HP L+Y + + Y + + E S S S + I
Sbjct: 855 TTGEAG--------HPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEI 906
Query: 1547 KLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLF----DEDLKEFTKPLYSD 1602
+G E +LG + +G L+P +YR + FT + ++ L + + S
Sbjct: 907 DVGNESTTLG---------YYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSF 957
Query: 1603 TFFSLPITTESEP--LFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIR 1660
+ +S ++ +P + GA+ G G +I V V + R+K ++ + +S
Sbjct: 958 SRYSDAVSLPQDPGVICGAVFGCIFGALVI---VTVGGFIFWRKK---RKDAKNNEVSFS 1011
Query: 1661 RDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCD 1720
+ +P K S I++ FE +F K QADSN ++EYE+LK VG +Q
Sbjct: 1012 QIKP-------------KKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKY 1058
Query: 1721 IALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLP 1780
A L ENRGKNRYNN+LPYD +RVKLS V DYINA+Y+PG + ++++I TQGPLP
Sbjct: 1059 AAELAENRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLP 1117
Query: 1781 GTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPE 1840
T DFW+MVWE+NV+ I+M+T+CVE+GR KC+ YWP+ Q + YGD+ + M SE VLPE
Sbjct: 1118 NTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQ-AQDYGDITVAMTSEIVLPE 1176
Query: 1841 WTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPT 1900
WTIR+F + + ++H L R FH+T WPDHGVP+TT LI F VRDY+ +SP P
Sbjct: 1177 WTIRDFTVKNIQTSESHPL-RQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPI 1235
Query: 1901 VVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 1960
+VHCSAGVGRTGTFIA+DR++ Q++++++VD+YG V+DLR+HR MVQTE QYV+L+QCV
Sbjct: 1236 LVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCV 1295
Query: 1961 RDVLRARKLRS----EQENPLFPIYENVNP 1986
D++R++K Q IYEN+ P
Sbjct: 1296 LDIVRSQKDSKVDLIYQNTTAMTIYENLAP 1325
Score = 62.8 bits (151), Expect = 3e-09
Identities = 136/647 (21%), Positives = 247/647 (38%), Gaps = 109/647 (16%)
Query: 80 CNLQDLQAGTIYNFRII------SLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWT 133
CN+ L+ T Y F I + + R + + T+P+P + V+ +L W+
Sbjct: 171 CNITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALS--WS 228
Query: 134 PSSGKVTSYEV-QLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRS 192
+G + + + + + Q ++Q + S L G +YNI + K
Sbjct: 229 NGNGTASCRVLLESIGSHEELTQDSRLQVNIS-------GLKPGVQYNINPYLLQSNK-- 279
Query: 193 FSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRL-----MLMDKGILVHGGV 247
TK + L + N ER R + D+ ++ G
Sbjct: 280 --------------------TKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLV---GP 316
Query: 248 VDKHA------TSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLV--RTAPMEVSNLKVTN 299
VD + T GL PG YN TV ++AA + + + RT ++V ++ N
Sbjct: 317 VDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVN 376
Query: 300 DGSLTSLKVKWQ--------------RPPGNVDSYNITLSHKGTIKESRVLAPWITETHF 345
S TSL + W+ G DS N+ +S E R + P + + F
Sbjct: 377 I-SATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVS------EPRAVIPGLRSSTF 429
Query: 346 KELVPGRLYQVTVSCVSGELSAQKMAVG-RTFPDKVANLEANNNGRMRSLVVSWSPPAGD 404
Y +TV V G++ + T P V++ + ++WS + D
Sbjct: 430 --------YNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTE-IGLAWS--SHD 478
Query: 405 WEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVE--SGNLKNSERCQ 462
E +++ + + + + ++ + GL PG +Y E++ + +G S
Sbjct: 479 AESFQMHITQEGAGNSRVEITTNQSIII---GGLFPGTKYCFEIVPKGPNGTEGASRTVC 535
Query: 463 GRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTF 522
RTVP AV + V + T + + W++P E Y+ L + + + D K T
Sbjct: 536 NRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASE-YVYHLVIESKHGSNHTSTYD-KAITL 593
Query: 523 TDLVPGRKYMATVT-SISGDLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGD 581
L+PG Y T++ + + +S T P+ V+++ V+ T++ +W
Sbjct: 594 QGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTN--TTAATLSWQNFDDA 651
Query: 582 VEFYQVLLIHENVVIKNESISSET----SRYSFHSLKSGSLYSV-VVTTVSGGISSRQVV 636
Y L+ E + + T + + L GS Y+V + V GI S +
Sbjct: 652 SPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLE-- 709
Query: 637 VEGR----TVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLS 679
GR T P+S++ + L + W PG +E+ +S
Sbjct: 710 -PGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVS 755
Score = 59.7 bits (143), Expect = 3e-08
Identities = 143/685 (20%), Positives = 262/685 (38%), Gaps = 81/685 (11%)
Query: 458 SERCQGRTVPLAVLQLRVKHANETSLSIMWQT--PVAEWEKYIISLA---DRDLLLIHKS 512
S++ T P V ++ + T++ + W++ A KY++ ++ + ++H+
Sbjct: 110 SQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQP 169
Query: 513 LSKDAKEFTFTDLVPGRKYMATVTSISGDLK--NSSSVKGRTVPAQVTDLHVANQGMTSS 570
T L P Y+ ++T G+ + +K T P V+DL VA G+ +
Sbjct: 170 WCN------ITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKA 223
Query: 571 LFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGI 630
+ W+ G +VLL E++ E + + LK G Y++ +
Sbjct: 224 ALS-WSNGNGTASC-RVLL--ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
Query: 631 SSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAP-------GDVDNYEVTLSHDGK 683
+ + + G+ +N+ R+ S + AP G VD S D +
Sbjct: 280 TKGDPL-------GTEGGLDASNTERSRAGSPT---APVHDESLVGPVDPSSGQQSRDTE 329
Query: 684 VVQSLVIAKSVRECSFSSLTPGRLYTVTITTRS-----GKYENHSFSQERTVPDKVQGVS 738
V+ L PG Y T+ +++ G+ + F V V+
Sbjct: 330 VL-------------LVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVN 376
Query: 739 VSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSV 798
+S ++ + +VS ++ ++ Y++ + + + + ++ SE V L Y++
Sbjct: 377 ISATSLTLIWKVSDNESSSNYT-YKIHVAGETD---SSNLNVSEPRAVIPGLRSSTFYNI 432
Query: 799 TVTTKSGQYEANEQG-NGRTIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEI-QLLFN 856
TV G E T P PV D + ST ++ + WS + + Q I Q
Sbjct: 433 TVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAG 492
Query: 857 DMKVFPPFHLVNTATEYRFTSLTPGRQY--KILVLTISGDVQQSAFIEGFTVPSAVKNIH 914
+ +V + T L PG +Y +I+ +G S + TVPSAV +IH
Sbjct: 493 NSRV-----EITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIH 547
Query: 915 ISPNGATDSLTVNW-TPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQ 973
+ T + ++W +P G Y + + T K + T L G Y
Sbjct: 548 V-VYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAI---TLQGLIPGTLYN 603
Query: 974 IMIASVSGSLKNQINVVGR-TVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLT 1032
I I+ + N + T P++V + D + ++ + +SWQ + Y LL
Sbjct: 604 ITISPEVDHVWGDPNSTAQYTRPSNVSNI--DVSTNTTAATLSWQNFDDASPTYSYCLLI 661
Query: 1033 ENGILLRNTSEPAT---TKQHKFEDLTPGKKYKIQILT-VSGGLFSKE-AQTEGRTVPAA 1087
E N ++ T +L PG Y ++I V G+ S E + T PA+
Sbjct: 662 EKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPAS 721
Query: 1088 VT--DLRITENSTRHLSFRWTASEG 1110
+ D + L +WT G
Sbjct: 722 MASFDCEVVPKEPA-LVLKWTCPPG 745
Score = 58.2 bits (139), Expect = 8e-08
Identities = 120/579 (20%), Positives = 228/579 (39%), Gaps = 75/579 (12%)
Query: 82 LQDLQAGTIYNFRIISL------DEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPS 135
L L+ GT YN + S + + + +T+ + F V+ ++TSL + W S
Sbjct: 332 LVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQV--FDVTAVNISATSLTLIWKVS 389
Query: 136 SGKVTS---YEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRS 192
+ +S Y++ + E + + + E + L + + YNI + V G
Sbjct: 390 DNESSSNYTYKIHVAGETDSS--NLNVSEPRA----VIPGLRSSTFYNITVCPVLGDIEG 443
Query: 193 FSVYTNGSTVPSPVKDIGISTKANSLL-ISWSHGSGNVERYRLMLMDKGILVHGGVVDKH 251
+ T P PV D ++ + + + ++WS S + E +++ + +G + V
Sbjct: 444 TPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWS--SHDAESFQMHITQEG-AGNSRVEITT 500
Query: 252 ATSYAFHGLTPGYLYNLTVM------TEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTS 305
S GL PG Y ++ TE A R RT P V ++ V + T
Sbjct: 501 NQSIIIGGLFPGTKYCFEIVPKGPNGTEGAS----RTVCNRTVPSAVFDIHVVY-VTTTE 555
Query: 306 LKVKWQRPPGNVD-SYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGE 364
+ + W+ P G + Y++ + K + IT + L+PG LY +T+S
Sbjct: 556 MWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAIT---LQGLIPGTLYNITISPEVDH 612
Query: 365 LSAQKMAVGR-TFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNIT 423
+ + + T P V+N++ + N +L W+ + S LL
Sbjct: 613 VWGDPNSTAQYTRPSNVSNIDVSTNTTAATL---------SWQNFDDASPTYSYCLLIEK 663
Query: 424 VGKEE--TQYVMD-------DTGLVPGRQYEVEVIVESGN-LKNSE--RCQGRTVPLAVL 471
G TQ V D T L+PG Y VE+ + G+ +K+ E R T P ++
Sbjct: 664 AGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMA 723
Query: 472 QLRVKHA-NETSLSIMWQTPV---AEWEKYIISLADRDLLLIHKSLSKDAKEF--TFTDL 525
+ E +L + W P A +E + S A + + S++ E+ T L
Sbjct: 724 SFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYL 783
Query: 526 VPGRKYMATVTSIS-----GDLKN--SSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQA 578
Y ++T++S +N ++ + P ++ + F+ + +
Sbjct: 784 NFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEAS 843
Query: 579 QGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGS 617
G ++ Y V+L + S++ +Y++ K G+
Sbjct: 844 HGPIKAYAVIL----TTGEAGHPSADVLKYTYEDFKKGA 878
Score = 37.4 bits (85), Expect = 0.15
Identities = 79/348 (22%), Positives = 141/348 (40%), Gaps = 51/348 (14%)
Query: 1257 SRTAPSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALT---VFNPYNNRK 1313
S T PSP + I+ T++ +TWK + ++ + T V P+ N
Sbjct: 115 SSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCN-- 172
Query: 1314 SEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIAC 1373
+ GLRP SY F++ G+ +T+ P V T+P + +L A
Sbjct: 173 -----ITGLRPATSYVFSITPGIGN--ETWGDPRVIKVITEPIPVSDLRVALTGVRKAAL 225
Query: 1374 SWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKEKSL-LNIMMLVPHKRY------LVSIK 1426
SW S+ +G + CR + + + +L ++ L +NI L P +Y L S K
Sbjct: 226 SW----SNGNG-TASCRVL-LESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
Query: 1427 VQSAGMTSEVVEDSTITMIDR--PPPPPPHIR--VNEKDVLISKSSINFTVNCSWFSDTN 1482
+ + +E D++ T R P P H V D + S + V
Sbjct: 280 TKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDTEV---LLVGLE 336
Query: 1483 GAVKYFTVVVREADGSDELKPEQQHPLPSYLEYRHNASIRVYQ---TNYFAS------KC 1533
+Y V +A E +P+ +E+R NA I+V+ N A+ K
Sbjct: 337 PGTRYNATVYSQAANGTEGQPQA-------IEFRTNA-IQVFDVTAVNISATSLTLIWKV 388
Query: 1534 AENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISI 1581
++N +S++ ++ I + E +S + ++ + L+ T Y I++
Sbjct: 389 SDNESSSNYTYKIHVAGETDS--SNLNVSEPRAVIPGLRSSTFYNITV 434
>gi|4506323 receptor-type protein tyrosine phosphatase O isoform b
precursor [Homo sapiens]
Length = 1188
Score = 306 bits (783), Expect = 2e-82
Identities = 177/423 (41%), Positives = 252/423 (59%), Gaps = 27/423 (6%)
Query: 1571 LKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSA-GLFL 1629
L P TAY S+ +F+ P + TE P I ++ L
Sbjct: 783 LLPATAYNCSVTSFSH---------DSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLL 833
Query: 1630 IGMLVAVVALLICRQK-VSHGRERPSARL----SIRRDRPLSVHLNLGQKGNRKTSCPIK 1684
IG+L+ V L+I R+K + RE + S+ RD L + + RK + P++
Sbjct: 834 IGLLL--VTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQ 891
Query: 1685 INQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRV 1744
++ F+ + + DS+Y S ++EELK +G + A LP NR KNRY NILPYD +RV
Sbjct: 892 LDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRV 951
Query: 1745 KLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQC 1804
+L +++++ +DYINA+YIPG N +EYI TQGPLP T++DFWKMV +Q IVM+TQC
Sbjct: 952 RLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQC 1011
Query: 1805 VEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFH 1864
EK RVKCDHYWP ++ + YGD+ ++M+SE +W R F+I D + + HF+
Sbjct: 1012 NEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI---NYADEMQDVMHFN 1068
Query: 1865 YTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQ 1922
YT WPDHGVP +S++QFV VR +S GP ++HCSAGVGRTGTFIALDR+LQ
Sbjct: 1069 YTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDRLLQ 1126
Query: 1923 QLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYE 1982
+ + VDI G V ++R +R+ MVQTE QY+++HQCV+ + +K +Q IYE
Sbjct: 1127 HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK---QQFCISDVIYE 1183
Query: 1983 NVN 1985
NV+
Sbjct: 1184 NVS 1186
>gi|13677220 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 303 bits (776), Expect = 1e-81
Identities = 165/364 (45%), Positives = 234/364 (64%), Gaps = 17/364 (4%)
Query: 1629 LIGMLVAVVALLICRQK-VSHGRERPSARL----SIRRDRPLSVHLNLGQKGNRKTSCPI 1683
LIG+L+ V L+I R+K + RE + S+ RD L + + RK + P+
Sbjct: 22 LIGLLL--VTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPV 79
Query: 1684 KINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATR 1743
+++ F+ + + DS+Y S ++EELK +G + A LP NR KNRY NILPYD +R
Sbjct: 80 QLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSR 139
Query: 1744 VKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQ 1803
V+L +++++ +DYINA+YIPG N +EYI TQGPLP T++DFWKMV +Q IVM+TQ
Sbjct: 140 VRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQ 199
Query: 1804 CVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHF 1863
C EK RVKCDHYWP ++ + YGD+ ++M+SE +W R F+I D + + HF
Sbjct: 200 CNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI---NYADEMQDVMHF 256
Query: 1864 HYTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRIL 1921
+YT WPDHGVP +S++QFV VR +S GP ++HCSAGVGRTGTFIALDR+L
Sbjct: 257 NYTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDRLL 314
Query: 1922 QQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIY 1981
Q + + VDI G V ++R +R+ MVQTE QY+++HQCV+ + +K +Q IY
Sbjct: 315 QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK---QQFCISDVIY 371
Query: 1982 ENVN 1985
ENV+
Sbjct: 372 ENVS 375
>gi|13677216 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 303 bits (776), Expect = 1e-81
Identities = 165/364 (45%), Positives = 234/364 (64%), Gaps = 17/364 (4%)
Query: 1629 LIGMLVAVVALLICRQK-VSHGRERPSARL----SIRRDRPLSVHLNLGQKGNRKTSCPI 1683
LIG+L+ V L+I R+K + RE + S+ RD L + + RK + P+
Sbjct: 22 LIGLLL--VTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPV 79
Query: 1684 KINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATR 1743
+++ F+ + + DS+Y S ++EELK +G + A LP NR KNRY NILPYD +R
Sbjct: 80 QLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSR 139
Query: 1744 VKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQ 1803
V+L +++++ +DYINA+YIPG N +EYI TQGPLP T++DFWKMV +Q IVM+TQ
Sbjct: 140 VRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQ 199
Query: 1804 CVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHF 1863
C EK RVKCDHYWP ++ + YGD+ ++M+SE +W R F+I D + + HF
Sbjct: 200 CNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI---NYADEMQDVMHF 256
Query: 1864 HYTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRIL 1921
+YT WPDHGVP +S++QFV VR +S GP ++HCSAGVGRTGTFIALDR+L
Sbjct: 257 NYTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDRLL 314
Query: 1922 QQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIY 1981
Q + + VDI G V ++R +R+ MVQTE QY+++HQCV+ + +K +Q IY
Sbjct: 315 QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK---QQFCISDVIY 371
Query: 1982 ENVN 1985
ENV+
Sbjct: 372 ENVS 375
>gi|13677222 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 297 bits (760), Expect = 8e-80
Identities = 154/329 (46%), Positives = 217/329 (65%), Gaps = 13/329 (3%)
Query: 1662 DRPLSVHLNLGQKGN---RKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQS 1718
D L+ ++N K RK + P++++ F+ + + DS+Y S ++EELK +G +
Sbjct: 83 DYLLAFYINPWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIP 142
Query: 1719 CDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGP 1778
A LP NR KNRY NILPYD +RV+L +++++ +DYINA+YIPG N +EYI TQGP
Sbjct: 143 HFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGP 202
Query: 1779 LPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVL 1838
LP T++DFWKMV +Q IVM+TQC EK RVKCDHYWP ++ + YGD+ ++M+SE
Sbjct: 203 LPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQ 262
Query: 1839 PEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPG 1896
+W R F+I D + + HF+YT WPDHGVP +S++QFV VR +S
Sbjct: 263 DDWACRHFRI---NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKS-- 317
Query: 1897 AGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYL 1956
GP ++HCSAGVGRTGTFIALDR+LQ + + VDI G V ++R +R+ MVQTE QY+++
Sbjct: 318 KGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFI 377
Query: 1957 HQCVRDVLRARKLRSEQENPLFPIYENVN 1985
HQCV+ + +K +Q IYENV+
Sbjct: 378 HQCVQLMWMKKK---QQFCISDVIYENVS 403
>gi|13677218 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 297 bits (760), Expect = 8e-80
Identities = 154/329 (46%), Positives = 217/329 (65%), Gaps = 13/329 (3%)
Query: 1662 DRPLSVHLNLGQKGN---RKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQS 1718
D L+ ++N K RK + P++++ F+ + + DS+Y S ++EELK +G +
Sbjct: 83 DYLLAFYINPWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIP 142
Query: 1719 CDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGP 1778
A LP NR KNRY NILPYD +RV+L +++++ +DYINA+YIPG N +EYI TQGP
Sbjct: 143 HFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGP 202
Query: 1779 LPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVL 1838
LP T++DFWKMV +Q IVM+TQC EK RVKCDHYWP ++ + YGD+ ++M+SE
Sbjct: 203 LPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQ 262
Query: 1839 PEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPG 1896
+W R F+I D + + HF+YT WPDHGVP +S++QFV VR +S
Sbjct: 263 DDWACRHFRI---NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKS-- 317
Query: 1897 AGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYL 1956
GP ++HCSAGVGRTGTFIALDR+LQ + + VDI G V ++R +R+ MVQTE QY+++
Sbjct: 318 KGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFI 377
Query: 1957 HQCVRDVLRARKLRSEQENPLFPIYENVN 1985
HQCV+ + +K +Q IYENV+
Sbjct: 378 HQCVQLMWMKKK---QQFCISDVIYENVS 403
>gi|13677214 receptor-type protein tyrosine phosphatase O isoform a
precursor [Homo sapiens]
Length = 1216
Score = 297 bits (760), Expect = 8e-80
Identities = 154/329 (46%), Positives = 217/329 (65%), Gaps = 13/329 (3%)
Query: 1662 DRPLSVHLNLGQKGN---RKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQS 1718
D L+ ++N K RK + P++++ F+ + + DS+Y S ++EELK +G +
Sbjct: 894 DYLLAFYINPWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIP 953
Query: 1719 CDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGP 1778
A LP NR KNRY NILPYD +RV+L +++++ +DYINA+YIPG N +EYI TQGP
Sbjct: 954 HFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGP 1013
Query: 1779 LPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVL 1838
LP T++DFWKMV +Q IVM+TQC EK RVKCDHYWP ++ + YGD+ ++M+SE
Sbjct: 1014 LPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQ 1073
Query: 1839 PEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPG 1896
+W R F+I D + + HF+YT WPDHGVP +S++QFV VR +S
Sbjct: 1074 DDWACRHFRI---NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKS-- 1128
Query: 1897 AGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYL 1956
GP ++HCSAGVGRTGTFIALDR+LQ + + VDI G V ++R +R+ MVQTE QY+++
Sbjct: 1129 KGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFI 1188
Query: 1957 HQCVRDVLRARKLRSEQENPLFPIYENVN 1985
HQCV+ + +K +Q IYENV+
Sbjct: 1189 HQCVQLMWMKKK---QQFCISDVIYENVS 1214
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 296 bits (758), Expect = 1e-79
Identities = 388/1552 (25%), Positives = 656/1552 (42%), Gaps = 191/1552 (12%)
Query: 552 TVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFH 611
+ P +T ++++ G F + G ++ Y + L N + +I++ + +
Sbjct: 761 SAPENITYKNISS-GEIELSFLPPSSPNGIIQKYTIYLKRSNGN-EERTINTTSLTQNIK 818
Query: 612 SLKSGSLYSVVVT--TVSG-GISSRQV-VVEGRTVPSS---------VSGVTVNNSGRND 658
LK + Y + V+ T+ G G+ S + ++ P S +SGVTV
Sbjct: 819 VLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVK------ 872
Query: 659 YLSVSWL--LAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRS 716
+SW L P + Y + ++++ + ++ E S VT +TR
Sbjct: 873 ---LSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRF 929
Query: 717 GKYENHS----FSQERTVP-DKVQGVSVSNSARSDYLRVSWVHAT---GDFDHYEVTIKN 768
G + S F P D + V +N + S + + W + G +Y V +N
Sbjct: 930 GDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSII-LFWTPPSKPNGIIQYYSVYYRN 988
Query: 769 KNN-FIQTKSIPKSENE-------CVFVQLVPGRLYSVTVTTKSGQYEANEQGN------ 814
+ F+Q ++ + N+ + +L Y+ +T + N+ +
Sbjct: 989 TSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYT 1048
Query: 815 GRTIPEP-VKDLTLRNRSTEDLHVTW---SGANGDVDQYEIQLLFNDMK-VFPPFHLVNT 869
+ IPE V +LT + S+ ++V+W + NG V Y +L + V PP LV
Sbjct: 1049 DQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPP--LVTY 1106
Query: 870 ATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFT----------VPSAVKNIHISPNG 919
F +L Y IL +T S + F + +T VP I+ N
Sbjct: 1107 ERSIYFDNLEKYTDY-ILKITPS---TEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNL 1162
Query: 920 ATDSLTVNWTPG---GGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMI 976
++ S+ ++W P G + SY ++ ++ T ++ L Y
Sbjct: 1163 SSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYII---LEELSPFTLYSFFA 1219
Query: 977 ASVSGSLKNQINVV----GRTVP-ASVQGVIADNAYSSYSLIVSWQKA---AGVAERYDI 1028
A+ + +++ +VP A Q + N S + + + W + G+ + Y
Sbjct: 1220 AARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDF-VWLKWSPSPLPGGIVKVYSF 1278
Query: 1029 LLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVS----GGLFSKEAQ-TEGRT 1083
+ + + + K L P Y I++ + G FS + T +
Sbjct: 1279 KIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQES 1338
Query: 1084 VPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQN 1143
VP V +++ S + + +W + ++ + N +V P ++F
Sbjct: 1339 VPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERN---STKVSPQDHMYTFIK 1395
Query: 1144 LLQGRMY--KMVIVTHSGELSNESFIFGRTVPASV----SHLRGSNRNTTDSL--WFNWS 1195
LL Y K+ T +GE +ES T+P +V +++ S+ +T + W
Sbjct: 1396 LLANTSYVFKVRASTSAGE-GDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPD 1454
Query: 1196 PASGDFDFYELILYNPNGTKKENWKDKD--------------LTEWRFQGLVPGRKYVLW 1241
G F Y+ I K + W+ ++ LTE GL R Y
Sbjct: 1455 TILGYFQNYK-ITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQ 1513
Query: 1242 VVTHS----GDLSNKVTAESRTAP--SPPSLMSFADIANTSLAITWKGPPDWTDYNDF-- 1293
V + G+ SN ++ ++ P PP + + S++I+W P T +
Sbjct: 1514 VAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEPAVITGPTCYLI 1573
Query: 1294 ELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGD------SWKTYSKPI 1347
+++ + D + +N +++ + L Y + +G+ K+ ++ I
Sbjct: 1574 DVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMI 1633
Query: 1348 FGSVRTKP-DKIQNLHCR--PQNSTAIACSWIPP---DSDFDGY-SIECRKMDTQEVEFS 1400
++ + P D N+ + P T +++PP + + Y ++ R+ D V+
Sbjct: 1634 VTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIH 1693
Query: 1401 RK--LEKEKSLLNIMM--LVPHKRYLVSI-KVQSAGMTSEVVEDST--ITMIDRPPPPPP 1453
++K + + M+ L Y +S+ V SAG +V T I RP P
Sbjct: 1694 NLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPMRITMDIKAPARPKTKPT 1753
Query: 1454 HIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYL 1513
I +L++ ++I + ++SD +G +K V+V E + + Y
Sbjct: 1754 PIYDATGKLLVTSTTITIRMPICYYSDDHGPIKNVQVLVTETGAQHDGNVTKW-----YD 1808
Query: 1514 EYRHNASIRVYQTN--YFASKCAENPNSNSKSFNIKL-GAEMESLGGKCDPTQQKFCDGP 1570
Y + A R Y TN + C E S + I + GA+ + + K C+GP
Sbjct: 1809 AYFNKA--RPYFTNEGFPNPPCTEGKTKFSGNEEIYIIGADNACM---IPGNEDKICNGP 1863
Query: 1571 LKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGV--SAGLF 1628
LKP Y RA + +FT YSD P+ T E L + S L
Sbjct: 1864 LKPKKQYLFKFRA-----TNIMGQFTDSDYSD-----PVKTLGEGLSERTVEIILSVTLC 1913
Query: 1629 LIGMLV---AVVALLICRQKVSHG-----RERPSARLSIRRDRPLSV-HLNLGQK----- 1674
++ +++ A+ A RQK G ++ ++ D+ ++V L L +
Sbjct: 1914 ILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTRL 1973
Query: 1675 -GNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRY 1733
RK+ PI F H +L ++N +E+ EL ++ S A LP NR KNR+
Sbjct: 1974 LSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRF 2033
Query: 1734 NNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQ 1793
NI PY+ RVKL P SDYINASYI G E+I TQGPLPGT DFW+MVWE
Sbjct: 2034 PNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWET 2093
Query: 1794 NVHNIVMVTQCVEKGRVKCDHYWPADQDSL-YYGDLILQMLSESVLPEWTIREFKICGEE 1852
+VM+TQC EKGR++C YWP D + +GD+++ L E V +WTIR+ KI E
Sbjct: 2094 RAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI---E 2150
Query: 1853 QLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTG 1912
+ +R ++T WP+HGVPE + LI FV+ VR +R+ P +VHCSAGVGRTG
Sbjct: 2151 RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVR--ASRAHDTTPMIVHCSAGVGRTG 2208
Query: 1913 TFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL 1964
FIALD + Q ++ D VDIYG V +LR R+ MVQ QY++LHQC+ D+L
Sbjct: 2209 VFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL 2260
Score = 53.5 bits (127), Expect = 2e-06
Identities = 197/1029 (19%), Positives = 377/1029 (36%), Gaps = 158/1029 (15%)
Query: 341 TETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVA------------------- 381
T+ +VPG Y +T+S +S ++ + T K
Sbjct: 17 TQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGILLSW 76
Query: 382 NLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPG 441
N N NGR+ S +V + W Q V + + + ++ T L PG
Sbjct: 77 NTPPNPNGRIISYIVKYKEVC-PWMQ---------TVYTQVRSKPDSLEVLL--TNLNPG 124
Query: 442 RQYEVEVIVES----GNLKNSERCQ-GRTVPLAVLQLRVKHANETSLSIMW---QTPVAE 493
YE++V E+ G + Q + P V+ L V+ N +++ ++W + P +
Sbjct: 125 TTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGK 184
Query: 494 WEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTV 553
+ IS+ ++ K +S D++ G+ +NS S T
Sbjct: 185 ITSFKISVKHARSGIVVKDVS-----IRVEDILTGKLPECN--------ENSESFLWSTA 231
Query: 554 PAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSL 613
T V T+ + TQ +E + E IS + ++
Sbjct: 232 SPSPTLGRVTPPSRTTHSSSTLTQ-------------NEISSVWKEPISFVVTHLRPYTT 278
Query: 614 KSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSV--SGVTVNNSGRNDYLSVSW---LLAP 668
L+ V T G +V +VP + VT N +G++ S+ W +
Sbjct: 279 Y---LFEVSAATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKS--FSILWDPPTIVT 333
Query: 669 GDVDNYEVTL-SHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRS----GKYENHS 723
G +Y V L G+++ + + + +F++LTP +Y V I + G N S
Sbjct: 334 GKF-SYRVELYGPSGRILDN---STKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNIS 389
Query: 724 FSQERTVPDKVQGVSVSNSARSDYLRVSWV---HATGDFDHYEVTIK-NKNNFIQTKSIP 779
VP V + ++ S +R++W G + Y V + + I ++
Sbjct: 390 VFTPPDVPGAVFDLQLAE-VESTQVRITWKKPRQPNGIINQYRVKVLVPETGIILENTLL 448
Query: 780 KSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIP--------EPVKDLTLRNRS 831
NE + + P + ++ V G YE + + + P K+ RNR+
Sbjct: 449 TGNNEYINDPMAP-EIVNI-VEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRA 506
Query: 832 TEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPF--HLVNTATEYRFTSLTPGRQYKILVL 889
+ + N + + L ++ PF H+++ + FT + G + V
Sbjct: 507 EDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSA---FTIMGEGPPTVLSVR 563
Query: 890 TISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPG---GGDVDSYTVSAFRHS 946
T VPS++K I+ N ++ S+ + W P G + YT+ A
Sbjct: 564 TRQ------------QVPSSIKIINYK-NISSSSILLYWDPPEYPNGKITHYTIYAMELD 610
Query: 947 QK-------VDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINV-VGRTVPASV 998
+D+ + + ++T +++ + +S+S +N I V P S
Sbjct: 611 TNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSE--ENDIFVRTSEDEPESS 668
Query: 999 QGVIADNAYSSYSLIVSW---QKAAGVAERYDILLLTENGILLRNTSEPATTKQHKFEDL 1055
+ ++ + + W +K G+ Y++L + + ++NTS T +L
Sbjct: 669 PQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTS----TTDIILRNL 724
Query: 1056 TPGKKYKIQILT---------VSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWT 1106
P Y I + + VS L + ++T + P +T I+ +
Sbjct: 725 RPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPS 784
Query: 1107 ASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGELSNE-- 1164
+ G + Y I+L +GN + L Q+ + ++ T GE
Sbjct: 785 SPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAP 844
Query: 1165 -SFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPA---SGDFDFYELILYNPNGTKKENWK 1220
S + P S + + ++ +W P +G +Y + ++N + K N
Sbjct: 845 ISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVT 904
Query: 1221 DKDLTEWRFQGLVPGRKYVLWVVTHSGD---LSNKVTAES-RTAPS-PPSLMSFADIANT 1275
+ L V YV T GD SN ++ ++ APS PP + +A+++++
Sbjct: 905 ETSLELSDLDYNVEYSAYVT-ASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSS 963
Query: 1276 SLAITWKGP 1284
S+ + W P
Sbjct: 964 SIILFWTPP 972
Score = 45.4 bits (106), Expect = 5e-04
Identities = 35/167 (20%), Positives = 70/167 (41%), Gaps = 18/167 (10%)
Query: 1225 TEWRFQGLVPGRKYVLWVVTHSGDLSNKVT---AESRTAPSPPSLMSFADIANTSLAITW 1281
T+ +VPG +Y + + + S ++ VT + T P PP ++ + + + ++W
Sbjct: 17 TQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGILLSW 76
Query: 1282 KGPPD--------WTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVY-GLRPGRSYQFNV 1332
PP+ Y + W+ TV+ ++ ++ L PG +Y+ V
Sbjct: 77 NTPPNPNGRIISYIVKYKEV-CPWMQ----TVYTQVRSKPDSLEVLLTNLNPGTTYEIKV 131
Query: 1333 KTVSGDSWKTYSKP-IFGSVRTKPDKIQNLHCRPQNSTAIACSWIPP 1378
+ +S P +F + + P K+ NL N++A+ W P
Sbjct: 132 AAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLP 178
Score = 38.9 bits (89), Expect = 0.051
Identities = 52/257 (20%), Positives = 112/257 (43%), Gaps = 37/257 (14%)
Query: 1261 PSPPSLMSFADIANTSLAITWKGPPDW-----TDYNDFELQWLPRDALTVFNPYNNRKSE 1315
PS ++++ +I+++S+ + W PP++ T Y + ++ A + N+
Sbjct: 569 PSSIKIINYKNISSSSILLYWD-PPEYPNGKITHYTIYAMELDTNRAFQITTIDNSF--- 624
Query: 1316 GRIVYGLRPGRSYQFNV--KTVSGDSWKTYSKPIFGSVRTKPDKI----QNLHCRPQNST 1369
++ GL+ Y+ V T G+S + IF VRT D+ Q++ +
Sbjct: 625 --LITGLKKYTKYKMRVAASTHVGESSLSEENDIF--VRTSEDEPESSPQDVEVIDVTAD 680
Query: 1370 AIACSWIPPDSD---FDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMM--LVPHKRYLVS 1424
I W PP+ Y + + +DT + K S +I++ L PH Y +S
Sbjct: 681 EIRLKWSPPEKPNGIIIAYEVLYKNIDTLYM-------KNTSTTDIILRNLRPHTLYNIS 733
Query: 1425 IKVQSA-GMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNG 1483
++ + G ++V ++ + P P + K++ + ++F S NG
Sbjct: 734 VRSYTRFGHGNQVSSLLSVRTSETVPDSAPE-NITYKNISSGEIELSFLPP----SSPNG 788
Query: 1484 AVKYFTVVVREADGSDE 1500
++ +T+ ++ ++G++E
Sbjct: 789 IIQKYTIYLKRSNGNEE 805
>gi|241896926 protein tyrosine phosphatase, receptor type, H isoform 2
precursor [Homo sapiens]
Length = 937
Score = 280 bits (717), Expect = 8e-75
Identities = 152/372 (40%), Positives = 217/372 (58%), Gaps = 24/372 (6%)
Query: 1618 GAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNR 1677
G I G G+ L +LV ++ + R+ +++P R L G+
Sbjct: 575 GVIAGAFVGILLFLILVGLLIFFLKRRNKKK-QQKPELR-----------DLVFSSPGD- 621
Query: 1678 KTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNIL 1737
I F H K + DSN + +Y++L VG +QS +A EN KNRY N+L
Sbjct: 622 -----IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVL 676
Query: 1738 PYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN 1797
PYD +RV L + ++P SDYINAS++PG +E+I TQGPLP T DFW++VWEQ H
Sbjct: 677 PYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHT 736
Query: 1798 IVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH 1857
+VM+T C+E GRVKC+HYWP D +G L + ++ E V+ WT+RE + E+
Sbjct: 737 LVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEE-QKT 795
Query: 1858 RLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIAL 1917
+R FHY WPDHGVP + +L+ F R +R +++++ GP +VHCSAGVGRTGT IAL
Sbjct: 796 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 855
Query: 1918 DRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV-RDVLRARKLRSEQENP 1976
D +L+QL S+ + + V +R R MVQTE QYV+LHQC+ R + ++ + +E+E P
Sbjct: 856 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVP 915
Query: 1977 LFP----IYENV 1984
IYENV
Sbjct: 916 YEDVENLIYENV 927
Score = 81.3 bits (199), Expect = 9e-15
Identities = 128/580 (22%), Positives = 222/580 (38%), Gaps = 56/580 (9%)
Query: 1 MLSHGAGLALWITLSLLQ----TGLAEPE-RCNFTLAESKASSHSVSIQWRILGSPCNFS 55
M G GL +W L LL TG P L ++ S+S+ W + + +
Sbjct: 1 MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN 60
Query: 56 LIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRI-ISLDEER----TVVLQTDP 110
Y G R + T + L G++Y + + D TV T P
Sbjct: 61 SNYWVQCTGDGGTTETR-NTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAP 119
Query: 111 LPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSYEVQLFDENNQKIQGVQIQESTSWNE 167
P V E T++S+ + W G + ++Y V+ + G ST+
Sbjct: 120 NPVRNLTV--EAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG-----GRAGTRSTAHTN 172
Query: 168 YTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKAN-SLLISWSHGS 226
T L G Y ++ G S N +T P+PV+++ + T+ N S+ + W
Sbjct: 173 ITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPD 232
Query: 227 GNVER---YRLMLMDKGILVHGGVVDKHA--TSYAFHGLTPGYLYNLTVMTEAAGLQNYR 281
G + Y + G GG ++ TS L PG LY +V E G + R
Sbjct: 233 GPYPQDYTYWVEYTGDG----GGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSR 288
Query: 282 WKL-VRTAPMEVSNLKVTNDGSLTSLKVKWQRPPG-NVDSYNITLSH-KGTIKESRVLAP 338
+ + T P V++L D + +++ ++W P G SY+ +S + + + R +
Sbjct: 289 QNVSISTVPNAVTSLS-KQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQST 347
Query: 339 WITETHFKELVPGRLYQVTVSCVSGELSAQKMAV-GRTFPDKVANLEANNNGRMRSLVVS 397
T+ KEL G LY +TV E+ + T P++V +L+ N S+++
Sbjct: 348 SGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQ-NETQTKNSVMLW 406
Query: 398 WSPPAGDWEQYRILLF------------NDSVVLLNITVGKEETQYVMDDTGLVPGRQYE 445
W P Q + + +N T ET Y ++ L PG Y
Sbjct: 407 WKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVE--ALEPGTLYN 464
Query: 446 VEVIVESGNLKNSER--CQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLAD 503
V E ++ +S + C + V + ++++W P +E + + +
Sbjct: 465 FTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGG 524
Query: 504 RDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLK 543
+ + S + + L P R Y AT+T+I +K
Sbjct: 525 Q---RGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMK 561
Score = 69.7 bits (169), Expect = 3e-11
Identities = 125/555 (22%), Positives = 202/555 (36%), Gaps = 66/555 (11%)
Query: 819 PEPVKDLTLRNRSTEDLHVTWS---GANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRF 875
P P ++LT+ ++T + ++W G + Y +Q + TAT
Sbjct: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRN---TTATNVTV 86
Query: 876 TSLTPGRQYKILVLTISGDVQQSA-FIEGFTVPSAVKNIHISPNGATDSLTVNW-TPGGG 933
L PG Y V V S + T P+ V+N+ + S+ + W P G
Sbjct: 87 DGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQ-TNSSIALTWEVPDGP 145
Query: 934 DVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMI-ASVSGSLKNQINVVGR 992
D + T + T T RLE G Y + +G ++
Sbjct: 146 DPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNAT 205
Query: 993 TVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTE-----NGILLRNTSEPATT 1047
T P V+ + + +S S+ + W+ G + D E G RNT+ + T
Sbjct: 206 TAPNPVRNLHMETQTNS-SIALCWEVPDGPYPQ-DYTYWVEYTGDGGGTETRNTTNTSVT 263
Query: 1048 KQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTA 1107
E L PG Y + G TVP AVT L + + ++ RWTA
Sbjct: 264 A----ERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTA 319
Query: 1108 SEGE-LSWYNIFLYNPDGNLQERAQVDPLVQSFS-----FQNLLQGRMYKMVIVTHSGEL 1161
+G S Y+ ++ + DP QS S + L G +Y + + E+
Sbjct: 320 PQGPGQSSYSYWV-----SWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEV 374
Query: 1162 SN-ESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKK---- 1216
S + T P V+ L+ N T + W A GD +L +Y K
Sbjct: 375 RGYNSTLTAATAPNEVTDLQ--NETQTKNSVMLWWKAPGD-PHSQLYVYWVQWASKGHPR 431
Query: 1217 ------ENWKDK----DLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPSPPSL 1266
NW ++ + T ++ + L PG Y V D+++ + +S A + P
Sbjct: 432 RGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVAS--STQSLCASTYPDT 489
Query: 1267 MSFADIANTS----LAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI--VY 1320
++ +TS + + W P Y FEL+ + +R S G V
Sbjct: 490 VTITSCVSTSAGYGVNLIWSCPQG--GYEAFELE------VGGQRGSQDRSSCGEAVSVL 541
Query: 1321 GLRPGRSYQFNVKTV 1335
GL P RSY + T+
Sbjct: 542 GLGPARSYPATITTI 556
Score = 57.4 bits (137), Expect = 1e-07
Identities = 116/546 (21%), Positives = 194/546 (35%), Gaps = 63/546 (11%)
Query: 653 NSGRN--------DYLSVSWLLAPG---DVDNYEVTLSHDGKVVQSLVIAKSVRECSFSS 701
N GRN +S+SW + G NY V + DG ++ + +
Sbjct: 31 NPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETR--NTTATNVTVDG 88
Query: 702 LTPGRLYTVTI-TTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFD 760
L PG LYT ++ + G + T P+ V+ ++V S + ++W G
Sbjct: 89 LGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSS-IALTWEVPDGPDP 147
Query: 761 H---YEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTT-KSGQYEANEQGNGR 816
Y V T+S + +L PG LY +V K+G + E N
Sbjct: 148 QNSTYGVEYTGDGGRAGTRST--AHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNAT 205
Query: 817 TIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFT 876
T P PV++L + ++ + + W +G Q D + + TE R T
Sbjct: 206 TAPNPVRNLHMETQTNSSIALCWEVPDGPYPQ--------DYTYWVEYTGDGGGTETRNT 257
Query: 877 S--------LTPGRQYKILVLTISGDVQQS-AFIEGFTVPSAVKNIHISPNGATDSLTVN 927
+ L PG Y V + S + TVP+AV ++ + ++ +
Sbjct: 258 TNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLS-KQDWTNSTIALR 316
Query: 928 WT-PGGGDVDSYT--VSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLK 984
WT P G SY+ VS R D +T + T LEAG Y + + + ++
Sbjct: 317 WTAPQGPGQSSYSYWVSWVREGM-TDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVR 375
Query: 985 N-QINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTE---NGILLR- 1039
+ T P V + N + + ++ W KA G + + G R
Sbjct: 376 GYNSTLTAATAPNEVTDL--QNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRG 433
Query: 1040 --------NTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDL 1091
N + +K E L PG Y + + S T P VT
Sbjct: 434 QDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTIT 493
Query: 1092 RITENSTRH-LSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMY 1150
S + ++ W+ +G + + + G+ Q+R+ ++ S L R Y
Sbjct: 494 SCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGS-QDRSSCG---EAVSVLGLGPARSY 549
Query: 1151 KMVIVT 1156
I T
Sbjct: 550 PATITT 555
Score = 54.7 bits (130), Expect = 9e-07
Identities = 97/527 (18%), Positives = 198/527 (37%), Gaps = 41/527 (7%)
Query: 566 GMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTT 625
G+ S W Q GD E+ ++ + + L GSLY+ V
Sbjct: 55 GLDSQNSNYWVQCTGDGG-------------TTETRNTTATNVTVDGLGPGSLYTCSVWV 101
Query: 626 VSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPG-DVDNYEVTLSHDGKV 684
G++S V T P+ V +TV + N ++++W + G D N + + G
Sbjct: 102 EKDGVNSSVGTVTTATAPNPVRNLTV-EAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG 160
Query: 685 VQSLVIAKSVRECSFSSLTPGRLYTVTI-TTRSGKYENHSFSQERTVPDKVQGVSVSNSA 743
++ + + + L PG LY ++ ++G + T P+ V+ + +
Sbjct: 161 GRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQT 220
Query: 744 RSDYLRVSWVHATGDF-DHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTV-T 801
S + + W G + Y ++ + T++ + +L PG LY+ +V
Sbjct: 221 NSS-IALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWA 279
Query: 802 TKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANG-DVDQYEIQLLFNDMKV 860
K+G + + + T+P V L+ ++ + + + W+ G Y + + +
Sbjct: 280 EKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGM 339
Query: 861 FPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQ-QSAFIEGFTVPSAVKNIHISPNG 919
P + T+ L G Y + V +V+ ++ + T P+ V ++
Sbjct: 340 TDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQ- 398
Query: 920 ATDSLTVNWTPGGGDVDS----YTV--SAFRHSQKVD-------SQTIPKHVFEHTFHRL 966
T + + W GD S Y V ++ H ++ +QT + + L
Sbjct: 399 -TKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEAL 457
Query: 967 EAGEQYQIMI-ASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAER 1025
E G Y + A + + ++ T P +V + + Y + + W G E
Sbjct: 458 EPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEA 517
Query: 1026 YDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGL 1072
+++ + + G R++ A + L P + Y I T+ G+
Sbjct: 518 FELEVGGQRGSQDRSSCGEAVS----VLGLGPARSYPATITTIWDGM 560
Score = 45.1 bits (105), Expect = 7e-04
Identities = 52/208 (25%), Positives = 84/208 (40%), Gaps = 25/208 (12%)
Query: 1186 TTDSLWFNWSPASG----DFDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLW 1241
TT S+ +W G + +++ + T+ N ++T GL PG Y
Sbjct: 42 TTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVT---VDGLGPGSLYTCS 98
Query: 1242 VVTHSGDLSNKV-TAESRTAPSPPSLMSFADIANTSLAITWK---GPPDWTDYNDFELQW 1297
V +++ V T + TAP+P ++ N+S+A+TW+ GP E
Sbjct: 99 VWVEKDGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTG 158
Query: 1298 LPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNV---KTVSGDSWKTYSKPIFGSVRTK 1354
A T + N V L PG Y F+V K S +T + T
Sbjct: 159 DGGRAGTRSTAHTNIT-----VDRLEPGCLYVFSVWVGKNGINSSRETRN------ATTA 207
Query: 1355 PDKIQNLHCRPQNSTAIACSWIPPDSDF 1382
P+ ++NLH Q +++IA W PD +
Sbjct: 208 PNPVRNLHMETQTNSSIALCWEVPDGPY 235
>gi|241896924 protein tyrosine phosphatase, receptor type, H isoform 1
precursor [Homo sapiens]
Length = 1115
Score = 280 bits (717), Expect = 8e-75
Identities = 152/372 (40%), Positives = 217/372 (58%), Gaps = 24/372 (6%)
Query: 1618 GAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNR 1677
G I G G+ L +LV ++ + R+ +++P R L G+
Sbjct: 753 GVIAGAFVGILLFLILVGLLIFFLKRRNKKK-QQKPELR-----------DLVFSSPGD- 799
Query: 1678 KTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNIL 1737
I F H K + DSN + +Y++L VG +QS +A EN KNRY N+L
Sbjct: 800 -----IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVL 854
Query: 1738 PYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN 1797
PYD +RV L + ++P SDYINAS++PG +E+I TQGPLP T DFW++VWEQ H
Sbjct: 855 PYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHT 914
Query: 1798 IVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH 1857
+VM+T C+E GRVKC+HYWP D +G L + ++ E V+ WT+RE + E+
Sbjct: 915 LVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEE-QKT 973
Query: 1858 RLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIAL 1917
+R FHY WPDHGVP + +L+ F R +R +++++ GP +VHCSAGVGRTGT IAL
Sbjct: 974 LSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIAL 1033
Query: 1918 DRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV-RDVLRARKLRSEQENP 1976
D +L+QL S+ + + V +R R MVQTE QYV+LHQC+ R + ++ + +E+E P
Sbjct: 1034 DVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVP 1093
Query: 1977 LFP----IYENV 1984
IYENV
Sbjct: 1094 YEDVENLIYENV 1105
Score = 99.0 bits (245), Expect = 4e-20
Identities = 169/741 (22%), Positives = 282/741 (38%), Gaps = 83/741 (11%)
Query: 110 PLPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSYEVQLFDENNQKIQGVQIQESTSWN 166
P P ++ E T++S+ + W G + ++Y VQ + G +T+
Sbjct: 28 PAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDG-----GTTETRNTTAT 82
Query: 167 EYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKAN-SLLISWSHG 225
T L GS Y ++ G S +T P+PV+++ + + N S+ ++W
Sbjct: 83 NVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVP 142
Query: 226 SG-NVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYR-WK 283
G + + + G G T+ GL PG LY ++ G+ + R +
Sbjct: 143 DGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETR 202
Query: 284 LVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITET 343
TA V NL+V + +S+ + W+ P G D N T + T R T+T
Sbjct: 203 NATTAHNPVRNLRVEAQ-TTSSISLSWEVPDG-TDPQNSTYCVQCTGDGGRTETRNTTDT 260
Query: 344 H--FKELVPGRLYQVTVSC-VSGELSAQKMAVGRTFPDKVANL--EANNNGRMRSLVVSW 398
L PG LY +V G S+ ++ T P+ V NL EA N S+ ++W
Sbjct: 261 RVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNS---SIALTW 317
Query: 399 SPPAGDWEQ---YRILLFND-------SVVLLNITVGKEETQYVMDDTGLVPGRQYEVEV 448
P G Q Y + D S NITV + L PG Y V
Sbjct: 318 EVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDR-----------LEPGCLYVFSV 366
Query: 449 IVESGNLKNS-ERCQGRTVPLAVLQLRVKHANETSLSIMWQTP-------VAEWEKYIIS 500
V + +S E T P V L ++ +S+++ W+ P W +Y
Sbjct: 367 WVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGD 426
Query: 501 LADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNS-SSVKGRTVPAQVTD 559
+ + + T L PG Y +V + + S +V TVP VT
Sbjct: 427 GGGTE------TRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTS 480
Query: 560 LHVANQGMT-SSLFTNWTQAQGDVE---FYQVLLIHENVVIKNESISSETSRYSFHSLKS 615
L + Q T S++ WT QG + Y V + E + +S T + L++
Sbjct: 481 L--SKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTD-ITLKELEA 537
Query: 616 GSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDN-- 673
GSLY + V + + T P+ V+ + +N + W APGD +
Sbjct: 538 GSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVM--LWWKAPGDPHSQL 595
Query: 674 --YEVTLS-----HDGKVVQSLVIAKSVRE----CSFSSLTPGRLYTVTITTRSGKYENH 722
Y V + G+ Q+ + ++ R +L PG LY T+ +
Sbjct: 596 YVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASS 655
Query: 723 SFSQ-ERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPKS 781
+ S T PD V S +++ + + W G ++ +E+ + + S ++
Sbjct: 656 TQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEA 715
Query: 782 ENECVFVQLVPGRLYSVTVTT 802
+ + L P R Y T+TT
Sbjct: 716 VS---VLGLGPARSYPATITT 733
Score = 86.7 bits (213), Expect = 2e-16
Identities = 166/739 (22%), Positives = 270/739 (36%), Gaps = 91/739 (12%)
Query: 653 NSGRN--------DYLSVSWLLAPG---DVDNYEVTLSHDGKVVQSLVIAKSVRECSFSS 701
N GRN +S+SW + G NY V + DG ++ + +
Sbjct: 31 NPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETR--NTTATNVTVDG 88
Query: 702 LTPGRLYTVTI-TTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFD 760
L PG LYT ++ + G + T P+ V+ + V S + ++W G
Sbjct: 89 LGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSS-IALTWEVPDGPDP 147
Query: 761 H---YEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTT-KSGQYEANEQGNGR 816
Y V T+S + L PG LY+ ++ K+G + E N
Sbjct: 148 QNSTYGVEYTGDGGRAGTRST--AHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNAT 205
Query: 817 TIPEPVKDLTLRNRSTEDLHVTWSGANGDVDQ---YEIQLLFNDMKVFPPFHLVNTATEY 873
T PV++L + ++T + ++W +G Q Y +Q + + T+
Sbjct: 206 TAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTE-----TRNTTDT 260
Query: 874 RFT--SLTPGRQYKILVLTISGDVQQSA-FIEGFTVPSAVKNIHISPNGATDSLTVNW-T 929
R T L PG Y V V S + T P+ V+N+ + S+ + W
Sbjct: 261 RVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQ-TNSSIALTWEV 319
Query: 930 PGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMI-ASVSGSLKNQIN 988
P G D + T + T T RLE G Y + +G ++
Sbjct: 320 PDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRET 379
Query: 989 VVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTE-----NGILLRNTSE 1043
T P V+ + + +S S+ + W+ G + D E G RNT+
Sbjct: 380 RNATTAPNPVRNLHMETQTNS-SIALCWEVPDGPYPQ-DYTYWVEYTGDGGGTETRNTTN 437
Query: 1044 PATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSF 1103
+ T E L PG Y + G TVP AVT L + + ++
Sbjct: 438 TSVTA----ERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIAL 493
Query: 1104 RWTASEGE-LSWYNIFLYNPDGNLQERAQVDPLVQSFS-----FQNLLQGRMYKMVIVTH 1157
RWTA +G S Y+ ++ + DP QS S + L G +Y + +
Sbjct: 494 RWTAPQGPGQSSYSYWV-----SWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAE 548
Query: 1158 SGELSN-ESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKK 1216
E+ S + T P V+ L+ N T + W A GD +L +Y K
Sbjct: 549 RNEVRGYNSTLTAATAPNEVTDLQ--NETQTKNSVMLWWKAPGD-PHSQLYVYWVQWASK 605
Query: 1217 ----------ENWKDK----DLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTAPS 1262
NW ++ + T ++ + L PG Y V D+++ + +S A +
Sbjct: 606 GHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVAS--STQSLCAST 663
Query: 1263 PPSLMSFADIANTS----LAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI 1318
P ++ +TS + + W P Y FEL+ + +R S G
Sbjct: 664 YPDTVTITSCVSTSAGYGVNLIWSCPQG--GYEAFELE------VGGQRGSQDRSSCGEA 715
Query: 1319 --VYGLRPGRSYQFNVKTV 1335
V GL P RSY + T+
Sbjct: 716 VSVLGLGPARSYPATITTI 734
Score = 74.7 bits (182), Expect = 8e-13
Identities = 104/467 (22%), Positives = 184/467 (39%), Gaps = 45/467 (9%)
Query: 104 VVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSYEVQLFDENNQKIQGVQIQ 160
V T P P V E T++S+ + W G + ++Y V+ + G
Sbjct: 291 VTSATAPNPVRNLTV--EAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG-----GRAGT 343
Query: 161 ESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKAN-SLL 219
ST+ T L G Y ++ G S N +T P+PV+++ + T+ N S+
Sbjct: 344 RSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIA 403
Query: 220 ISWSHGSGNVER---YRLMLMDKGILVHGGVVDKHA--TSYAFHGLTPGYLYNLTVMTEA 274
+ W G + Y + G GG ++ TS L PG LY +V E
Sbjct: 404 LCWEVPDGPYPQDYTYWVEYTGDG----GGTETRNTTNTSVTAERLEPGTLYTFSVWAEK 459
Query: 275 AGLQNYRWKL-VRTAPMEVSNLKVTNDGSLTSLKVKWQRPPG-NVDSYNITLSH-KGTIK 331
G + R + + T P V++L D + +++ ++W P G SY+ +S + +
Sbjct: 460 NGARGSRQNVSISTVPNAVTSLS-KQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMT 518
Query: 332 ESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAV-GRTFPDKVANLEANNNGR 390
+ R + T+ KEL G LY +TV E+ + T P++V +L+ N
Sbjct: 519 DPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQ-NETQT 577
Query: 391 MRSLVVSWSPPAGDWEQYRILLF------------NDSVVLLNITVGKEETQYVMDDTGL 438
S+++ W P Q + + +N T ET Y ++ L
Sbjct: 578 KNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVE--AL 635
Query: 439 VPGRQYEVEVIVESGNLKNSER--CQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEK 496
PG Y V E ++ +S + C + V + ++++W P +E
Sbjct: 636 EPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEA 695
Query: 497 YIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLK 543
+ + + + + S + + L P R Y AT+T+I +K
Sbjct: 696 FELEVGGQ---RGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMK 739
Score = 70.5 bits (171), Expect = 2e-11
Identities = 139/709 (19%), Positives = 268/709 (37%), Gaps = 44/709 (6%)
Query: 393 SLVVSWSPPAGDWEQ---YRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVI 449
S+ +SW P G Q Y + D T + T + GL PG Y V
Sbjct: 45 SISLSWEVPDGLDSQNSNYWVQCTGDG----GTTETRNTTATNVTVDGLGPGSLYTCSVW 100
Query: 450 VESGNLKNSE-RCQGRTVPLAVLQLRVKHANETSLSIMWQTPVA---EWEKYIISLADRD 505
VE + +S T P V LRV+ +S+++ W+ P + Y +
Sbjct: 101 VEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG 160
Query: 506 LLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQ-VTDLHVAN 564
+S + T L PG Y ++ + +S + T V +L V
Sbjct: 161 GRAGTRSTAHT--NITVDGLEPGCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEA 218
Query: 565 QGMTSSLFTNWTQAQG-DVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVV 623
Q TSS+ +W G D + + + E+ ++ +R + L GSLY+ V
Sbjct: 219 Q-TTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSV 277
Query: 624 TTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPG-DVDNYEVTLSHDG 682
G++S +V T P+ V +TV + N ++++W + G D N + + G
Sbjct: 278 WVEKDGVNSSVEIVTSATAPNPVRNLTV-EAQTNSSIALTWEVPDGPDPQNSTYGVEYTG 336
Query: 683 KVVQSLVIAKSVRECSFSSLTPGRLYTVTI-TTRSGKYENHSFSQERTVPDKVQGVSVSN 741
++ + + + L PG LY ++ ++G + T P+ V+ + +
Sbjct: 337 DGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMET 396
Query: 742 SARSDYLRVSWVHATGDF-DHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTV 800
S + + W G + Y ++ + T++ + +L PG LY+ +V
Sbjct: 397 QTNSS-IALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSV 455
Query: 801 -TTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANG-DVDQYEIQLLFNDM 858
K+G + + + T+P V L+ ++ + + + W+ G Y + +
Sbjct: 456 WAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVRE 515
Query: 859 KVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQ-QSAFIEGFTVPSAVKNIHISP 917
+ P + T+ L G Y + V +V+ ++ + T P+ V ++
Sbjct: 516 GMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNET 575
Query: 918 NGATDSLTVNWTPGGGDVDS----YTV--SAFRHSQKVD-------SQTIPKHVFEHTFH 964
T + + W GD S Y V ++ H ++ +QT + +
Sbjct: 576 Q--TKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVE 633
Query: 965 RLEAGEQYQIMI-ASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVA 1023
LE G Y + A + + ++ T P +V + + Y + + W G
Sbjct: 634 ALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGY 693
Query: 1024 ERYDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGL 1072
E +++ + + G R++ A + L P + Y I T+ G+
Sbjct: 694 EAFELEVGGQRGSQDRSSCGEAVS----VLGLGPARSYPATITTIWDGM 738
Score = 65.5 bits (158), Expect = 5e-10
Identities = 114/577 (19%), Positives = 204/577 (35%), Gaps = 35/577 (6%)
Query: 819 PEPVKDLTLRNRSTEDLHVTW---SGANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRF 875
P P ++LT+ ++T + ++W G + Y +Q + TAT
Sbjct: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTET---RNTTATNVTV 86
Query: 876 TSLTPGRQYKILVLTISGDVQQS-AFIEGFTVPSAVKNIHISPNGATDSLTVNW-TPGGG 933
L PG Y V V S + T P+ V+N+ + S+ + W P G
Sbjct: 87 DGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQ-TNSSIALTWEVPDGP 145
Query: 934 DVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRT 993
D + T + T T LE G Y + + + T
Sbjct: 146 DPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNAT 205
Query: 994 VPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTSEPATTKQHKFE 1053
+ + A ++ S+ +SW+ G + + G R + T + +
Sbjct: 206 TAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVD 265
Query: 1054 DLTPGKKYKIQILTVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEG--- 1110
L PG Y + G+ S T P V +L + + ++ W +G
Sbjct: 266 GLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDP 325
Query: 1111 ELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKM-VIVTHSGELSNESFIFG 1169
+ S Y + G R+ + + L G +Y V V +G S+
Sbjct: 326 QNSTYGVEYTGDGGRAGTRSTAH---TNITVDRLEPGCLYVFSVWVGKNGINSSRETRNA 382
Query: 1170 RTVPASVSHLRGSNRNTTDSLWFNWSPASG----DFDFYELILYNPNGTKKENWKDKDLT 1225
T P V +L T S+ W G D+ ++ + GT+ N + +T
Sbjct: 383 TTAPNPVRNLH-METQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVT 441
Query: 1226 EWRFQGLVPGRKYVLWV-VTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSLAITWKGP 1284
R L PG Y V +G ++ T P+ + +S D N+++A+ W P
Sbjct: 442 AER---LEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAP 498
Query: 1285 --PDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI-VYGLRPGRSYQFNVKTVSGDSWK 1341
P + Y+ + + W+ R+ +T +P S I + L G Y V + +
Sbjct: 499 QGPGQSSYS-YWVSWV-REGMT--DPRTQSTSGTDITLKELEAGSLYHLTV-WAERNEVR 553
Query: 1342 TYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPP 1378
Y+ + + T P+++ +L Q ++ W P
Sbjct: 554 GYNSTL--TAATAPNEVTDLQNETQTKNSVMLWWKAP 588
Score = 60.8 bits (146), Expect = 1e-08
Identities = 127/629 (20%), Positives = 234/629 (37%), Gaps = 56/629 (8%)
Query: 37 SSHSVSIQWRILGSP----CNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYN 92
++ S+++ W + P + + Y+ D A T + T G L+ G +Y
Sbjct: 131 TNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDG-----LEPGCLYA 185
Query: 93 FR-------IISLDEERTVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSG---KVTSY 142
F I S E R +P+ R E T++S+ + W G + ++Y
Sbjct: 186 FSMWVGKNGINSSRETRNATTAHNPVRNLRV----EAQTTSSISLSWEVPDGTDPQNSTY 241
Query: 143 EVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTV 202
VQ + G +T+ T L GS Y ++ G S +T
Sbjct: 242 CVQCTGDG-----GRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATA 296
Query: 203 PSPVKDIGISTKAN-SLLISWSHGSG-NVERYRLMLMDKGILVHGGVVDKHATSYAFHGL 260
P+PV+++ + + N S+ ++W G + + + G G T+ L
Sbjct: 297 PNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRL 356
Query: 261 TPGYLYNLTVMTEAAGLQNYR-WKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPGNV-D 318
PG LY +V G+ + R + TAP V NL + + +S+ + W+ P G
Sbjct: 357 EPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTN-SSIALCWEVPDGPYPQ 415
Query: 319 SYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVG-RTFP 377
Y + + G + T + L PG LY +V + V T P
Sbjct: 416 DYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVP 475
Query: 378 DKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDT- 436
+ V +L + + ++ + W+ P G + + S V +T + ++ D T
Sbjct: 476 NAVTSL-SKQDWTNSTIALRWTAPQGPGQS--SYSYWVSWVREGMTDPRTQSTSGTDITL 532
Query: 437 -GLVPGRQYEVEVIVESGNLKN-SERCQGRTVPLAVLQLRVKHANETSLSIMWQT---PV 491
L G Y + V E ++ + T P V L+ + + S+ + W+ P
Sbjct: 533 KELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPH 592
Query: 492 AEWEKYIISLA---------DRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDL 542
++ Y + A D ++++ + + L PG Y TV + D+
Sbjct: 593 SQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDV 652
Query: 543 KNSS-SVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESI 601
+S+ S+ T P VT + + W+ QG E +++ + + ++
Sbjct: 653 ASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQR---GSQDR 709
Query: 602 SSETSRYSFHSLKSGSLYSVVVTTVSGGI 630
SS S L Y +TT+ G+
Sbjct: 710 SSCGEAVSVLGLGPARSYPATITTIWDGM 738
Score = 59.3 bits (142), Expect = 4e-08
Identities = 93/391 (23%), Positives = 143/391 (36%), Gaps = 41/391 (10%)
Query: 1011 SLIVSWQKAAGVAER---YDILLLTENGIL-LRNTSEPATTKQHKFEDLTPGKKYKIQIL 1066
S+ +SW+ G+ + Y + + G RNT+ T + L PG Y +
Sbjct: 45 SISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVT----VDGLGPGSLYTCSVW 100
Query: 1067 TVSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEG---ELSWYNIFLYNPD 1123
G+ S T P V +LR+ + ++ W +G + S Y +
Sbjct: 101 VEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDG 160
Query: 1124 GNLQERAQVDPLVQSFSFQNLLQGRMYKMVI-VTHSGELSNESFIFGRTVPASVSHLRGS 1182
G R+ + + L G +Y + V +G S+ T V +LR
Sbjct: 161 GRAGTRSTAHT---NITVDGLEPGCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLR-V 216
Query: 1183 NRNTTDSLWFNWSPASGDFDFYELILYNPNG----TKKENWKDKDLTEWRFQGLVPGRKY 1238
TT S+ +W G G T+ N D +T GL PG Y
Sbjct: 217 EAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVT---VDGLGPGSLY 273
Query: 1239 VLWV-VTHSGDLSNKVTAESRTAPSPPSLMSFADIANTSLAITWK---GPPDWTDYNDFE 1294
V V G S+ S TAP+P ++ N+S+A+TW+ GP E
Sbjct: 274 TCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVE 333
Query: 1295 LQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNV---KTVSGDSWKTYSKPIFGSV 1351
A T + N V L PG Y F+V K S +T +
Sbjct: 334 YTGDGGRAGTRSTAHTNIT-----VDRLEPGCLYVFSVWVGKNGINSSRETRN------A 382
Query: 1352 RTKPDKIQNLHCRPQNSTAIACSWIPPDSDF 1382
T P+ ++NLH Q +++IA W PD +
Sbjct: 383 TTAPNPVRNLHMETQTNSSIALCWEVPDGPY 413
Score = 43.1 bits (100), Expect = 0.003
Identities = 64/279 (22%), Positives = 107/279 (38%), Gaps = 35/279 (12%)
Query: 1186 TTDSLWFNWSPASG----DFDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLW 1241
TT S+ +W G + +++ + T+ N ++T GL PG Y
Sbjct: 42 TTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVT---VDGLGPGSLYTCS 98
Query: 1242 VVTHSGDLSNKV-TAESRTAPSPPSLMSFADIANTSLAITWK---GPPDWTDYNDFELQW 1297
V +++ V T + TAP+P + N+S+A+TW+ GP E
Sbjct: 99 VWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTG 158
Query: 1298 LPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNV---KTVSGDSWKTYSKPIFGSVRTK 1354
A T + N V GL PG Y F++ K S +T + T
Sbjct: 159 DGGRAGTRSTAHTNIT-----VDGLEPGCLYAFSMWVGKNGINSSRETRN------ATTA 207
Query: 1355 PDKIQNLHCRPQNSTAIACSWIPPDS---DFDGYSIECRKMDTQEVEFSRKLEKEKSLLN 1411
+ ++NL Q +++I+ SW PD Y ++C T + + + +
Sbjct: 208 HNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQC----TGDGGRTETRNTTDTRVT 263
Query: 1412 IMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPP 1450
+ L P Y S+ V+ G+ S V +T P P
Sbjct: 264 VDGLGPGSLYTCSVWVEKDGVNSSV---EIVTSATAPNP 299
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 252 bits (644), Expect = 2e-66
Identities = 250/953 (26%), Positives = 411/953 (43%), Gaps = 114/953 (11%)
Query: 1071 GLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERA 1130
G+ AQ + +P +TE++ ++ W + E Y I + P + +
Sbjct: 306 GVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 365
Query: 1131 QVDPLVQS-FSFQNLLQGRMY--KMVIVTHSGELSNESFIFGRT---VPASVSHLRGSNR 1184
++D + + +S L Y ++V V + G + +T P+S +
Sbjct: 366 EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARM 425
Query: 1185 NTTDSLWFNWSPA---SGDFDFYELIL-----YNPNGTKKENWKDKDLTEWRFQGLVPGR 1236
++ ++ W +G Y + + N K N D +T LVP +
Sbjct: 426 LSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT--IGNLVPQK 483
Query: 1237 KYVLWVVTHS----GDLSNKVTAESRTA-PSPPSLMSFADIANTSLAITWKGPPDWTDYN 1291
Y + V+ + G LS+ + ++T P P + TS+ ++W P T N
Sbjct: 484 TYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIAN 543
Query: 1292 DFELQWLP----RDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSKPI 1347
+EL + + P + + +G L+P Y F + S + I
Sbjct: 544 -YELVYKDGEHGEEQRITIEPGTSYRLQG-----LKPNSLYYFRLAARSPQGLGASTAEI 597
Query: 1348 FGSVRTKPDKI-QNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKE 1406
S RT +N H + T++ SW P++ + D + VE +
Sbjct: 598 --SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQ 655
Query: 1407 KSLLNIMMLVPHKRY--LVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLI 1464
K ++N L P K Y +++ + SAG V T + R P I
Sbjct: 656 KLIVN---LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKP-----------AFI 701
Query: 1465 SKSSIN--FTVNCSWFSDTNGAVKYFTVVV--READGS-------------DELKPEQQH 1507
K++++ TV Y+ ++V +++ G DEL E
Sbjct: 702 GKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISR 761
Query: 1508 PLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFC 1567
S + Y ++ Y +F E + K + GG F
Sbjct: 762 KRRS-IRYGREVELKPYIAAHFDVLPTEFTLGDDKHY-----------GG--------FT 801
Query: 1568 DGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSL-----PITTESEPLFGAIEG 1622
+ L+ Y + A + + K + YSD S+ PIT E E L +
Sbjct: 802 NKQLQSGQEYVFFVLAVME--HAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGP 859
Query: 1623 VSAGLFLIGMLVAVVALLICRQKVSHGR-ERPSARLSIRRDRPLSVH----------LNL 1671
V A +F+I + V+A+L+ + K R E S + SI ++ + H LN
Sbjct: 860 VLAVVFIICI---VIAILLYKSKPDRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNF 916
Query: 1672 GQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKN 1731
G + PI I + H +L+A+ N S+EYE + D G+ + + + L N+ KN
Sbjct: 917 QTPG-MASHPPIPILELADHIERLKANDNLKFSQEYESI-DPGQQFTWEHSNLEVNKPKN 974
Query: 1732 RYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVW 1791
RY N++ YD +RV LS ++ P SDY+NA+YI G + YI TQG LP T DFW+M+W
Sbjct: 975 RYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIW 1034
Query: 1792 EQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGE 1851
EQ +VM+T+ E+ RVKCD YWP+ + + +G + + +L L + +R F + +
Sbjct: 1035 EQRSATVVMMTKLEERSRVKCDQYWPS-RGTETHGLVQVTLLDTVELATYCVRTFALY-K 1092
Query: 1852 EQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRT 1911
R +R F +T WPDHGVPE + F+R V+ P AGP VVHCSAGVGRT
Sbjct: 1093 NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--NPPDAGPMVVHCSAGVGRT 1150
Query: 1912 GTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL 1964
G FI +D +L+++ + +VDIYG V +R R +MVQTE QY+++H + + +
Sbjct: 1151 GCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1203
Score = 194 bits (493), Expect = 7e-49
Identities = 103/243 (42%), Positives = 148/243 (60%), Gaps = 2/243 (0%)
Query: 1722 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1781
A LP N+ KNR NI+PY++TRV L + SDYINAS+I G ++ YI TQGPL
Sbjct: 1254 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1313
Query: 1782 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 1841
T +DFW+M+WE N +VM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1314 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1372
Query: 1842 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 1901
+REFK+ + + R +R F +T WP+ GVP++ + I F+ V + GP
Sbjct: 1373 ILREFKVT-DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1431
Query: 1902 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 1961
VHCSAGVGRTG FI L +L+++ + VDI+ V LR R MVQTE QY + ++
Sbjct: 1432 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAAL 1491
Query: 1962 DVL 1964
+ L
Sbjct: 1492 EYL 1494
Score = 50.4 bits (119), Expect = 2e-05
Identities = 97/500 (19%), Positives = 196/500 (39%), Gaps = 42/500 (8%)
Query: 950 DSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSS 1009
D I ++V E R A Y + S G ++ + + +P G ++
Sbjct: 277 DDMPIGRNVLELNDVRQSAN--YTCVAMSTLGVIEAIAQITVKALPKP-PGTPVVTESTA 333
Query: 1010 YSLIVSWQKAAGVAERYDILL-LTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTV 1068
S+ ++W Y I+ +N L + T ++ L+P Y+ +++ V
Sbjct: 334 TSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAV 393
Query: 1069 SG---GLFSKEA--QTEGRTVPAAVTDLRITENSTRHLSFRWTASE---GELSWYNIFLY 1120
+ G S+ QT + +A D++ S+ + +W E G++ Y ++ Y
Sbjct: 394 NNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY-Y 452
Query: 1121 NPD-----GNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHS----GELSNESFIFGRT 1171
D N + D + + NL+ + Y + ++ + G LS++ + +T
Sbjct: 453 TMDPTQHVNNWMKHNVADSQITTIG--NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQT 510
Query: 1172 -VPASVSHLRGSNRNTTDSLWFNWSPASGD-FDFYELILYNPNGTKKENWKDKDLTEWRF 1229
VP + + + T S+ +W+P D YEL+ + +++ + T +R
Sbjct: 511 GVPGQPLNFKAEPESET-SILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRL 569
Query: 1230 QGLVPGRKYVLWVVTHSGDLSNKVTAE--SRTAPSP-PSLMSFADIANTSLAITWKGPPD 1286
QGL P Y + S TAE +RT S + TS+ ++W+ P +
Sbjct: 570 QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPEN 629
Query: 1287 WTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNV----KTVSGDSWKT 1342
+ F++ + D + + R ++ +++ L+P +SY F + + G +
Sbjct: 630 YNSAMPFKILY---DDGKMVEEVDGRATQ-KLIVNLKPEKSYSFVLTNRGNSAGGLQHRV 685
Query: 1343 YSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRK 1402
+K +RTKP I + + +P + + GY I + +F +
Sbjct: 686 TAKTAPDVLRTKPAFIGKTNL--DGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKP 743
Query: 1403 LEK--EKSLLNIMMLVPHKR 1420
E E L ++ + KR
Sbjct: 744 WESPDEMELDELLKEISRKR 763
Score = 44.7 bits (104), Expect = 0.001
Identities = 90/366 (24%), Positives = 140/366 (38%), Gaps = 69/366 (18%)
Query: 16 LLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCN----FSLIYSSDTLGAALCPTF 71
L QT P + SS ++ +QW+ P + + Y+ D PT
Sbjct: 406 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMD-------PTQ 458
Query: 72 RIDNTTYGCNLQDLQAGTI--------YNFRIIS--------LDEERTVVLQTD-PLPPA 114
++N N+ D Q TI Y+ ++++ L + V+ QT P P
Sbjct: 459 HVNNWMKH-NVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPL 517
Query: 115 RFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSW-------NE 167
F E TS L W P S + +YE+ D + + Q + I+ TS+ N
Sbjct: 518 NFKAEPESETSILLS-WTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNS 576
Query: 168 YTFFNLTAGSKYNI-AITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGS 226
+F L A S + A TA + S++ V + +K S+L+SW
Sbjct: 577 LYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMK--------TSVLLSWEIPE 628
Query: 227 G-NVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTP--GYLYNLTVMTEAAGLQNYRW- 282
N +L D G +V VD AT L P Y + LT +AG +R
Sbjct: 629 NYNSAMPFKILYDDGKMVE--EVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVT 686
Query: 283 -----KLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPG--NVDSYNITLSHKGTIKESR- 334
++RT P + K DG +T V+ P N+ Y I + +K+SR
Sbjct: 687 AKTAPDVLRTKPAFIG--KTNLDGMIT---VQLPEVPANENIKGYYIIIV---PLKKSRG 738
Query: 335 -VLAPW 339
+ PW
Sbjct: 739 KFIKPW 744
Score = 37.7 bits (86), Expect = 0.11
Identities = 69/312 (22%), Positives = 120/312 (38%), Gaps = 33/312 (10%)
Query: 205 PVKDIGISTKANSLLISWSHGSGN-VERYRLMLMDKGILVHGGVVDKHATS-YAFHGLTP 262
P + + A S+ ++W G+ V Y + K +D AT+ Y+ GL+P
Sbjct: 323 PGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSP 382
Query: 263 GYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDG-----SLTSLKVKWQRPP--- 314
Y V+ + + V T E + D S T++ V+W+ P
Sbjct: 383 YSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPN 442
Query: 315 GNVDSYNITLSHKGTIKESRVLAPWITE---THFKELVPGRLYQVTV----SCVSGELSA 367
G + Y + + T + + + + T LVP + Y V V S G LS+
Sbjct: 443 GQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSS 502
Query: 368 QKMAVGRT-FPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGK 426
+ +T P + N +A S+++SW+PP D + N +V + G+
Sbjct: 503 DIQVITQTGVPGQPLNFKAEPESET-SILLSWTPPRSD------TIANYELVYKDGEHGE 555
Query: 427 EETQYVMDDT-----GLVPGRQYEVEVIVES--GNLKNSERCQGRTV-PLAVLQLRVKHA 478
E+ + T GL P Y + S G ++ RT+ + VK
Sbjct: 556 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAV 615
Query: 479 NETSLSIMWQTP 490
+TS+ + W+ P
Sbjct: 616 MKTSVLLSWEIP 627
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 251 bits (640), Expect = 7e-66
Identities = 249/952 (26%), Positives = 411/952 (43%), Gaps = 116/952 (12%)
Query: 1071 GLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERA 1130
G+ AQ + +P +TE++ ++ W + E Y I + P + +
Sbjct: 309 GVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYK 368
Query: 1131 QVDPLVQS-FSFQNLLQGRMY--KMVIVTHSGELSNESFIFGRT---VPASVSHLRGSNR 1184
++D + + +S L Y ++V V + G + +T P+S +
Sbjct: 369 EIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARM 428
Query: 1185 NTTDSLWFNWSPA---SGDFDFYELIL-----YNPNGTKKENWKDKDLTEWRFQGLVPGR 1236
++ ++ W +G Y + + N K N D +T LVP +
Sbjct: 429 LSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT--IGNLVPQK 486
Query: 1237 KYVLWVVTHS----GDLSNKVTAESRTA-PSPPSLMSFADIANTSLAITWKGPPDWTDYN 1291
Y + V+ + G LS+ + ++T P P + TS+ ++W P T N
Sbjct: 487 TYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIAN 546
Query: 1292 DFELQWLP----RDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSKPI 1347
+EL + + P + + +G L+P Y F + S + I
Sbjct: 547 -YELVYKDGEHGEEQRITIEPGTSYRLQG-----LKPNSLYYFRLAARSPQGLGASTAEI 600
Query: 1348 FGSVRTKPDKI-QNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKE 1406
S RT +N H + T++ SW P++ + D + VE +
Sbjct: 601 --SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQ 658
Query: 1407 KSLLNIMMLVPHKRY--LVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLI 1464
K ++N L P K Y +++ + SAG V T + R P I
Sbjct: 659 KLIVN---LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKP-----------AFI 704
Query: 1465 SKSSIN--FTVNCSWFSDTNGAVKYFTVVV--READGS-------------DELKPEQQH 1507
K++++ TV Y+ ++V +++ G DEL E
Sbjct: 705 GKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISR 764
Query: 1508 PLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFC 1567
S + Y ++ Y +F E + K + GG F
Sbjct: 765 KRRS-IRYGREVELKPYIAAHFDVLPTEFTLGDDKHY-----------GG--------FT 804
Query: 1568 DGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSL-----PITTESEPLFGAIEG 1622
+ L+ Y + A + + K + YSD S+ PIT E E L +
Sbjct: 805 NKQLQSGQEYVFFVLAVME--HAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGP 862
Query: 1623 VSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVH----------LNLG 1672
V A +F+I +++A+ LL R++ E S + SI ++ + H LN
Sbjct: 863 VLAVVFIICIVIAI--LLYKRKRA----ESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQ 916
Query: 1673 QKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNR 1732
G + PI I + H +L+A+ N S+EYE + D G+ + + + L N+ KNR
Sbjct: 917 TPG-MASHPPIPILELADHIERLKANDNLKFSQEYESI-DPGQQFTWEHSNLEVNKPKNR 974
Query: 1733 YNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWE 1792
Y N++ YD +RV LS ++ P SDY+NA+YI G + YI TQG LP T DFW+M+WE
Sbjct: 975 YANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWE 1034
Query: 1793 QNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEE 1852
Q +VM+T+ E+ RVKCD YWP+ + + +G + + +L L + +R F + +
Sbjct: 1035 QRSATVVMMTKLEERSRVKCDQYWPS-RGTETHGLVQVTLLDTVELATYCVRTFALY-KN 1092
Query: 1853 QLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTG 1912
R +R F +T WPDHGVPE + F+R V+ P AGP VVHCSAGVGRTG
Sbjct: 1093 GSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTC--NPPDAGPMVVHCSAGVGRTG 1150
Query: 1913 TFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL 1964
FI +D +L+++ + +VDIYG V +R R +MVQTE QY+++H + + +
Sbjct: 1151 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1202
Score = 194 bits (493), Expect = 7e-49
Identities = 103/243 (42%), Positives = 148/243 (60%), Gaps = 2/243 (0%)
Query: 1722 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1781
A LP N+ KNR NI+PY++TRV L + SDYINAS+I G ++ YI TQGPL
Sbjct: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312
Query: 1782 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 1841
T +DFW+M+WE N +VM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1313 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1371
Query: 1842 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 1901
+REFK+ + + R +R F +T WP+ GVP++ + I F+ V + GP
Sbjct: 1372 ILREFKVT-DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1430
Query: 1902 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 1961
VHCSAGVGRTG FI L +L+++ + VDI+ V LR R MVQTE QY + ++
Sbjct: 1431 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAAL 1490
Query: 1962 DVL 1964
+ L
Sbjct: 1491 EYL 1493
Score = 50.4 bits (119), Expect = 2e-05
Identities = 97/500 (19%), Positives = 196/500 (39%), Gaps = 42/500 (8%)
Query: 950 DSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSS 1009
D I ++V E R A Y + S G ++ + + +P G ++
Sbjct: 280 DDMPIGRNVLELNDVRQSAN--YTCVAMSTLGVIEAIAQITVKALPKP-PGTPVVTESTA 336
Query: 1010 YSLIVSWQKAAGVAERYDILL-LTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTV 1068
S+ ++W Y I+ +N L + T ++ L+P Y+ +++ V
Sbjct: 337 TSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAV 396
Query: 1069 SG---GLFSKEA--QTEGRTVPAAVTDLRITENSTRHLSFRWTASE---GELSWYNIFLY 1120
+ G S+ QT + +A D++ S+ + +W E G++ Y ++ Y
Sbjct: 397 NNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY-Y 455
Query: 1121 NPD-----GNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHS----GELSNESFIFGRT 1171
D N + D + + NL+ + Y + ++ + G LS++ + +T
Sbjct: 456 TMDPTQHVNNWMKHNVADSQITTIG--NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQT 513
Query: 1172 -VPASVSHLRGSNRNTTDSLWFNWSPASGD-FDFYELILYNPNGTKKENWKDKDLTEWRF 1229
VP + + + T S+ +W+P D YEL+ + +++ + T +R
Sbjct: 514 GVPGQPLNFKAEPESET-SILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRL 572
Query: 1230 QGLVPGRKYVLWVVTHSGDLSNKVTAE--SRTAPSP-PSLMSFADIANTSLAITWKGPPD 1286
QGL P Y + S TAE +RT S + TS+ ++W+ P +
Sbjct: 573 QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPEN 632
Query: 1287 WTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNV----KTVSGDSWKT 1342
+ F++ + D + + R ++ +++ L+P +SY F + + G +
Sbjct: 633 YNSAMPFKILY---DDGKMVEEVDGRATQ-KLIVNLKPEKSYSFVLTNRGNSAGGLQHRV 688
Query: 1343 YSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRK 1402
+K +RTKP I + + +P + + GY I + +F +
Sbjct: 689 TAKTAPDVLRTKPAFIGKTNL--DGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKP 746
Query: 1403 LEK--EKSLLNIMMLVPHKR 1420
E E L ++ + KR
Sbjct: 747 WESPDEMELDELLKEISRKR 766
Score = 44.7 bits (104), Expect = 0.001
Identities = 90/366 (24%), Positives = 140/366 (38%), Gaps = 69/366 (18%)
Query: 16 LLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCN----FSLIYSSDTLGAALCPTF 71
L QT P + SS ++ +QW+ P + + Y+ D PT
Sbjct: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMD-------PTQ 461
Query: 72 RIDNTTYGCNLQDLQAGTI--------YNFRIIS--------LDEERTVVLQTD-PLPPA 114
++N N+ D Q TI Y+ ++++ L + V+ QT P P
Sbjct: 462 HVNNWMKH-NVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPL 520
Query: 115 RFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSW-------NE 167
F E TS L W P S + +YE+ D + + Q + I+ TS+ N
Sbjct: 521 NFKAEPESETSILLS-WTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNS 579
Query: 168 YTFFNLTAGSKYNI-AITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGS 226
+F L A S + A TA + S++ V + +K S+L+SW
Sbjct: 580 LYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMK--------TSVLLSWEIPE 631
Query: 227 G-NVERYRLMLMDKGILVHGGVVDKHATSYAFHGLTP--GYLYNLTVMTEAAGLQNYRW- 282
N +L D G +V VD AT L P Y + LT +AG +R
Sbjct: 632 NYNSAMPFKILYDDGKMVE--EVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVT 689
Query: 283 -----KLVRTAPMEVSNLKVTNDGSLTSLKVKWQRPPG--NVDSYNITLSHKGTIKESR- 334
++RT P + K DG +T V+ P N+ Y I + +K+SR
Sbjct: 690 AKTAPDVLRTKPAFIG--KTNLDGMIT---VQLPEVPANENIKGYYIIIV---PLKKSRG 741
Query: 335 -VLAPW 339
+ PW
Sbjct: 742 KFIKPW 747
Score = 37.7 bits (86), Expect = 0.11
Identities = 69/312 (22%), Positives = 120/312 (38%), Gaps = 33/312 (10%)
Query: 205 PVKDIGISTKANSLLISWSHGSGN-VERYRLMLMDKGILVHGGVVDKHATS-YAFHGLTP 262
P + + A S+ ++W G+ V Y + K +D AT+ Y+ GL+P
Sbjct: 326 PGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSP 385
Query: 263 GYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDG-----SLTSLKVKWQRPP--- 314
Y V+ + + V T E + D S T++ V+W+ P
Sbjct: 386 YSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPN 445
Query: 315 GNVDSYNITLSHKGTIKESRVLAPWITE---THFKELVPGRLYQVTV----SCVSGELSA 367
G + Y + + T + + + + T LVP + Y V V S G LS+
Sbjct: 446 GQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSS 505
Query: 368 QKMAVGRT-FPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGK 426
+ +T P + N +A S+++SW+PP D + N +V + G+
Sbjct: 506 DIQVITQTGVPGQPLNFKAEPESET-SILLSWTPPRSD------TIANYELVYKDGEHGE 558
Query: 427 EETQYVMDDT-----GLVPGRQYEVEVIVES--GNLKNSERCQGRTV-PLAVLQLRVKHA 478
E+ + T GL P Y + S G ++ RT+ + VK
Sbjct: 559 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAV 618
Query: 479 NETSLSIMWQTP 490
+TS+ + W+ P
Sbjct: 619 MKTSVLLSWEIP 630
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 246 bits (627), Expect = 2e-64
Identities = 213/739 (28%), Positives = 340/739 (46%), Gaps = 105/739 (14%)
Query: 1274 NTSLAITWKGPPDWTD-----------YNDFELQWLPRDALTVFNPYNNRKSEGRIVYGL 1322
+TS+ ++W+ PP + Y D + LP + L V P + + + GL
Sbjct: 932 STSVQLSWQ-PPVLAERNGIITKYTLLYRDINIPLLPMEQLIV--PADTTMT----LTGL 984
Query: 1323 RPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKP-DKI--QNLHCRPQNSTAIACSWIPPD 1379
+P +Y V+ + YS + RT P D++ +N H + T++ SW P+
Sbjct: 985 KPDTTYDVKVRAHTSKGPGPYSPSV--QFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPE 1042
Query: 1380 SDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRY--LVSIKVQSAGMTSEVV 1437
+ + D + VE +K ++N L P K Y +++ + SAG V
Sbjct: 1043 NYNSAMPFKILYDDGKMVEEVDGRATQKLIVN---LKPEKSYSFVLTNRGNSAGGLQHRV 1099
Query: 1438 EDSTITMIDRPPPPPPHIRVNEKDVLISKSSIN--FTVNCSWFSDTNGAVKYFTVVV--R 1493
T + R P I K++++ TV Y+ ++V +
Sbjct: 1100 TAKTAPDVLRTKP-----------AFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLK 1148
Query: 1494 EADGS-------------DELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSN 1540
++ G DEL E S + Y ++ Y +F E +
Sbjct: 1149 KSRGKFIKPWESPDEMELDELLKEISRKRRS-IRYGREVELKPYIAAHFDVLPTEFTLGD 1207
Query: 1541 SKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLY 1600
K + GG F + L+ Y + A + + K + Y
Sbjct: 1208 DKHY-----------GG--------FTNKQLQSGQEYVFFVLAVME--HAESKMYATSPY 1246
Query: 1601 SDTFFSL-----PITTESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSA 1655
SD S+ PIT E E L + V A +F+I +++A+ LL R++ E S
Sbjct: 1247 SDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAI--LLYKRKRA----ESDSR 1300
Query: 1656 RLSIRRDRPLSVH----------LNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSK 1705
+ SI ++ + H LN G + PI I + H +L+A+ N S+
Sbjct: 1301 KSSIPNNKEIPSHHPTDPVELRRLNFQTPG-MASHPPIPILELADHIERLKANDNLKFSQ 1359
Query: 1706 EYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPG 1765
EYE + D G+ + + + L N+ KNRY N++ YD +RV LS ++ P SDY+NA+YI G
Sbjct: 1360 EYESI-DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG 1418
Query: 1766 NNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYY 1825
+ YI TQG LP T DFW+M+WEQ +VM+T+ E+ RVKCD YWP+ + + +
Sbjct: 1419 YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPS-RGTETH 1477
Query: 1826 GDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVR 1885
G + + +L L + +R F + + R +R F +T WPDHGVPE + F+R
Sbjct: 1478 GLVQVTLLDTVELATYCVRTFALY-KNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLR 1536
Query: 1886 TVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVH 1945
V+ P AGP VVHCSAGVGRTG FI +D +L+++ + +VDIYG V +R R +
Sbjct: 1537 RVKTC--NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1594
Query: 1946 MVQTECQYVYLHQCVRDVL 1964
MVQTE QY+++H + + +
Sbjct: 1595 MVQTEDQYIFIHDALLEAV 1613
Score = 194 bits (493), Expect = 7e-49
Identities = 103/243 (42%), Positives = 148/243 (60%), Gaps = 2/243 (0%)
Query: 1722 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1781
A LP N+ KNR NI+PY++TRV L + SDYINAS+I G ++ YI TQGPL
Sbjct: 1664 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1723
Query: 1782 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 1841
T +DFW+M+WE N +VM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1724 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1782
Query: 1842 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 1901
+REFK+ + + R +R F +T WP+ GVP++ + I F+ V + GP
Sbjct: 1783 ILREFKVT-DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1841
Query: 1902 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 1961
VHCSAGVGRTG FI L +L+++ + VDI+ V LR R MVQTE QY + ++
Sbjct: 1842 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAAL 1901
Query: 1962 DVL 1964
+ L
Sbjct: 1902 EYL 1904
Score = 61.6 bits (148), Expect = 7e-09
Identities = 138/715 (19%), Positives = 271/715 (37%), Gaps = 126/715 (17%)
Query: 884 YKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAF 943
Y + ++ G ++ A I +P ++ + AT S+T+ W G + SY +
Sbjct: 300 YTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTAT-SITLTWDSGNPEPVSYYI--I 356
Query: 944 RHSQKVDSQTIPKHV-----FEHTFHRLEAGEQYQIMIASVSGSLKNQ-----INVVGRT 993
+H K +S+ + K + ++ L Y+ + +V+ + +
Sbjct: 357 QHKPK-NSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQ 415
Query: 994 VPASVQGVIADNAYSSYSLIVSWQKAA---GVAERYDILLLTE-----NGILLRNTSEPA 1045
P+S + SS +++V W++ G + Y + + N + N ++
Sbjct: 416 APSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQ 475
Query: 1046 TTKQHKFEDLTPGKKYKIQIL---TVSGGLFSKEAQTEGRT-VPAAVTDLRITENSTRHL 1101
T +L P K Y +++L ++ G S + Q +T VP + + S +
Sbjct: 476 ITT---IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532
Query: 1102 SFRWTASEGE-LSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHS-- 1158
WT + ++ Y + + + ++R ++P S+ Q L +Y + S
Sbjct: 533 LLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGT-SYRLQGLKPNSLYYFRLAARSPQ 591
Query: 1159 GELSNESFIFGRTV---PASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTK 1215
G ++ + I RT+ P++ ++ S+ +W P + + Y+ T
Sbjct: 592 GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 651
Query: 1216 KENWKDK---------DLTEWRFQGLVPGRKYVLWVVTHSG------DLSNKVTAESRTA 1260
+ DK D T++ + L +Y + V H+ LS +
Sbjct: 652 VDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVP 711
Query: 1261 PSPPSLMSFADIANTSLAITW---------------------------KGPPDWTDYNDF 1293
PP + + +TS+ ++W KG P D
Sbjct: 712 SGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLA 771
Query: 1294 ELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVK--TVSGDSWKTYSKPI--FG 1349
+ QW +++ I+ GL+P SY V T GD ++ K + G
Sbjct: 772 DAQW----------EFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTG 821
Query: 1350 SVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDF---DGYSIECRKMDTQ---EVEFSRKL 1403
+V KP + N Q +TA+ W PP F GY ++ + D + +EFS K
Sbjct: 822 AVPGKPRLVIN---HTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEK- 876
Query: 1404 EKEKSLLNIMMLVPHK--RYLVSIKVQS-AGMTSEVVEDSTITMIDRPPPPPPHIRVNEK 1460
E + +I HK Y+ + ++ G E+V++ +I P +
Sbjct: 877 EDHFTATDI-----HKGASYVFRLSARNKVGFGEEMVKEISI---------PEEVPTGFP 922
Query: 1461 DVLISKSSINFTVNCSW----FSDTNGAVKYFTVVVREADGSDELKPEQQHPLPS 1511
L S+ + + +V SW ++ NG + +T++ R D + L P +Q +P+
Sbjct: 923 QNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR--DINIPLLPMEQLIVPA 975
Score = 61.2 bits (147), Expect = 1e-08
Identities = 155/720 (21%), Positives = 256/720 (35%), Gaps = 115/720 (15%)
Query: 16 LLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCN----FSLIYSSDTLGAALCPTF 71
L QT P + SS ++ +QW+ P + + Y+ D PT
Sbjct: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMD-------PTQ 461
Query: 72 RIDNTTYGCNLQDLQAGTI--------YNFRIIS--------LDEERTVVLQTD-PLPPA 114
++N N+ D Q TI Y+ ++++ L + V+ QT P P
Sbjct: 462 HVNNWMKH-NVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPL 520
Query: 115 RFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSW-------NE 167
F E TS L W P S + +YE+ D + + Q + I+ TS+ N
Sbjct: 521 NFKAEPESETSILLS-WTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNS 579
Query: 168 YTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIG-ISTKANSLLISW---- 222
+F L A S + + S T S +P +DI S + S+L+SW
Sbjct: 580 LYYFRLAARSPQGLGASTA-----EISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPP 634
Query: 223 -SHGSGNVERYRLMLM------DKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVM--TE 273
+G + Y + DK + G + T Y L Y +TV T+
Sbjct: 635 VEKQNGIITEYSIKYTAVDGEDDKPHEILG--IPSDTTKYLLEQLEKWTEYRITVTAHTD 692
Query: 274 AAGLQNYRWKLVRT------APMEVSNLKVTNDGSLTSLKVKWQRP-----PGNVDSYNI 322
L+RT P ++ N TS+KV W+ P G + Y +
Sbjct: 693 VGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNS---TSVKVSWRSPVPNKQHGQIRGYQV 749
Query: 323 --TLSHKGTIKESRVL-------APW-ITETHFKELVPGRLYQVTVSCVSGELSAQKMAV 372
G K +L A W +T +++ L T ++ K
Sbjct: 750 HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDG 809
Query: 373 GRTFPDKVANLEA--------NNNGRMRSLVVSWSPPA---GDWEQYRILL-FNDSVVLL 420
R+ P V+ A N+ +M + ++ W PP G + YR+ D L
Sbjct: 810 ARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLT 869
Query: 421 NITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAV-----LQLRV 475
+ ++E + D + G Y + + E + ++P V L
Sbjct: 870 TLEFSEKEDHFTATD--IHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHS 927
Query: 476 KHANETSLSIMWQTPVAEWEKYII---SLADRD----LLLIHKSLSKDAKEFTFTDLVPG 528
+ TS+ + WQ PV II +L RD LL + + + T T L P
Sbjct: 928 EGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPD 987
Query: 529 RKYMATVT--SISGDLKNSSSVKGRTVPAQ---VTDLHVANQGMTSSLFTNWTQAQGDVE 583
Y V + G S SV+ RT+P + HV M +S+ +W +
Sbjct: 988 TTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHV-KAVMKTSVLLSWEIPENYNS 1046
Query: 584 FYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVP 643
+++++ + E + ++ +LK YS V+T Q V +T P
Sbjct: 1047 AMPFKILYDDGKMV-EEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAP 1105
Score = 50.4 bits (119), Expect = 2e-05
Identities = 76/362 (20%), Positives = 147/362 (40%), Gaps = 33/362 (9%)
Query: 950 DSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSS 1009
D I ++V E R A Y + S G ++ + + +P G ++
Sbjct: 280 DDMPIGRNVLELNDVRQSAN--YTCVAMSTLGVIEAIAQITVKALPKP-PGTPVVTESTA 336
Query: 1010 YSLIVSWQKAAGVAERYDILL-LTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTV 1068
S+ ++W Y I+ +N L + T ++ L+P Y+ +++ V
Sbjct: 337 TSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAV 396
Query: 1069 SG---GLFSKEA--QTEGRTVPAAVTDLRITENSTRHLSFRWTASE---GELSWYNIFLY 1120
+ G S+ QT + +A D++ S+ + +W E G++ Y ++ Y
Sbjct: 397 NNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY-Y 455
Query: 1121 NPD-----GNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHS----GELSNESFIFGRT 1171
D N + D + + NL+ + Y + ++ + G LS++ + +T
Sbjct: 456 TMDPTQHVNNWMKHNVADSQITTIG--NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQT 513
Query: 1172 -VPASVSHLRGSNRNTTDSLWFNWSPASGD-FDFYELILYNPNGTKKENWKDKDLTEWRF 1229
VP + + + T S+ +W+P D YEL+ + +++ + T +R
Sbjct: 514 GVPGQPLNFKAEPESET-SILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRL 572
Query: 1230 QGLVPGRKYVLWVVTHSGDLSNKVTAE--SRTAPS----PPSLMSFADIANTSLAITWKG 1283
QGL P Y + S TAE +RT S PP +S ++TS+ ++W+
Sbjct: 573 QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQP 632
Query: 1284 PP 1285
PP
Sbjct: 633 PP 634
Score = 50.4 bits (119), Expect = 2e-05
Identities = 137/713 (19%), Positives = 263/713 (36%), Gaps = 91/713 (12%)
Query: 796 YSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGD-VDQYEIQLL 854
Y+ + G EA Q + +P+P + + + +TW N + V Y IQ
Sbjct: 300 YTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHK 359
Query: 855 -FNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTIS----GDVQQSAFIE-GFTVPS 908
N +++ V T T Y L+P Y+ V+ ++ G + + PS
Sbjct: 360 PKNSEELYKEIDGVAT-TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPS 418
Query: 909 AVKNIHISPNGATDSLTVNWTPG---GGDVDSYTVSAFRHSQKVDSQTIPKHVFEH---T 962
+ + ++ ++ V W G + Y V + + + +V + T
Sbjct: 419 SAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT 478
Query: 963 FHRLEAGEQYQIMIASVS----GSLKNQINVVGRT-VPASVQGVIADNAYSSYSLIVSWQ 1017
L + Y + + + + G L + I V+ +T VP A+ S S+++SW
Sbjct: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPE-SETSILLSWT 537
Query: 1018 KA-AGVAERYDILLLT-ENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSG-GLFS 1074
+ Y+++ E+G R T EP T+ ++ + L P Y ++ S GL +
Sbjct: 538 PPRSDTIANYELVYKDGEHGEEQRITIEPGTS--YRLQGLKPNSLYYFRLAARSPQGLGA 595
Query: 1075 KEAQTEGRTVP----AAVTDLRITENSTRHLSFRWTA-----SEGELSWYNIFLYNPDGN 1125
A+ RT+ A D+ T S+ + W G ++ Y+I DG
Sbjct: 596 STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 655
Query: 1126 LQERAQVDPL---VQSFSFQNLLQGRMYKMVIVTHS--GELSNESFIFGRT---VPASVS 1177
+ ++ + + + L + Y++ + H+ G + RT VP+
Sbjct: 656 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPP 715
Query: 1178 HLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKENWKDKDL----------TEW 1227
+ S+ +W + ++ Y + + EN + K +W
Sbjct: 716 RKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQW 775
Query: 1228 RFQ----------GLVPGRKYVLWVVTHS--GDLSN---KVTAESRTAPSPPSLMSFADI 1272
F GL P Y L V ++ GD + K+ + + P P L+
Sbjct: 776 EFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQ 835
Query: 1273 ANTSLAITWKGPPD-WTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFN 1331
NT+L I W P D + + L++ +D + + K + + G SY F
Sbjct: 836 MNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFR 894
Query: 1332 VKTVSGDSWKTYSKPIFGSVRTK----PDKI-----QNLHCRPQNSTAIACSWIPP---- 1378
+ +K FG K P+++ QNLH ST++ SW PP
Sbjct: 895 LSA--------RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAE 946
Query: 1379 -DSDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSA 1430
+ Y++ R ++ + + + + + + L P Y V ++ ++
Sbjct: 947 RNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTS 999
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 246 bits (627), Expect = 2e-64
Identities = 213/739 (28%), Positives = 340/739 (46%), Gaps = 105/739 (14%)
Query: 1274 NTSLAITWKGPPDWTD-----------YNDFELQWLPRDALTVFNPYNNRKSEGRIVYGL 1322
+TS+ ++W+ PP + Y D + LP + L V P + + + GL
Sbjct: 919 STSVQLSWQ-PPVLAERNGIITKYTLLYRDINIPLLPMEQLIV--PADTTMT----LTGL 971
Query: 1323 RPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKP-DKI--QNLHCRPQNSTAIACSWIPPD 1379
+P +Y V+ + YS + RT P D++ +N H + T++ SW P+
Sbjct: 972 KPDTTYDVKVRAHTSKGPGPYSPSV--QFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPE 1029
Query: 1380 SDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRY--LVSIKVQSAGMTSEVV 1437
+ + D + VE +K ++N L P K Y +++ + SAG V
Sbjct: 1030 NYNSAMPFKILYDDGKMVEEVDGRATQKLIVN---LKPEKSYSFVLTNRGNSAGGLQHRV 1086
Query: 1438 EDSTITMIDRPPPPPPHIRVNEKDVLISKSSIN--FTVNCSWFSDTNGAVKYFTVVV--R 1493
T + R P I K++++ TV Y+ ++V +
Sbjct: 1087 TAKTAPDVLRTKP-----------AFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLK 1135
Query: 1494 EADGS-------------DELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSN 1540
++ G DEL E S + Y ++ Y +F E +
Sbjct: 1136 KSRGKFIKPWESPDEMELDELLKEISRKRRS-IRYGREVELKPYIAAHFDVLPTEFTLGD 1194
Query: 1541 SKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLY 1600
K + GG F + L+ Y + A + + K + Y
Sbjct: 1195 DKHY-----------GG--------FTNKQLQSGQEYVFFVLAVME--HAESKMYATSPY 1233
Query: 1601 SDTFFSL-----PITTESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSA 1655
SD S+ PIT E E L + V A +F+I +++A+ LL R++ E S
Sbjct: 1234 SDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAI--LLYKRKRA----ESDSR 1287
Query: 1656 RLSIRRDRPLSVH----------LNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSK 1705
+ SI ++ + H LN G + PI I + H +L+A+ N S+
Sbjct: 1288 KSSIPNNKEIPSHHPTDPVELRRLNFQTPG-MASHPPIPILELADHIERLKANDNLKFSQ 1346
Query: 1706 EYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPG 1765
EYE + D G+ + + + L N+ KNRY N++ YD +RV LS ++ P SDY+NA+YI G
Sbjct: 1347 EYESI-DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG 1405
Query: 1766 NNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYY 1825
+ YI TQG LP T DFW+M+WEQ +VM+T+ E+ RVKCD YWP+ + + +
Sbjct: 1406 YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPS-RGTETH 1464
Query: 1826 GDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVR 1885
G + + +L L + +R F + + R +R F +T WPDHGVPE + F+R
Sbjct: 1465 GLVQVTLLDTVELATYCVRTFALY-KNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLR 1523
Query: 1886 TVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVH 1945
V+ P AGP VVHCSAGVGRTG FI +D +L+++ + +VDIYG V +R R +
Sbjct: 1524 RVKTC--NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1581
Query: 1946 MVQTECQYVYLHQCVRDVL 1964
MVQTE QY+++H + + +
Sbjct: 1582 MVQTEDQYIFIHDALLEAV 1600
Score = 194 bits (493), Expect = 7e-49
Identities = 103/243 (42%), Positives = 148/243 (60%), Gaps = 2/243 (0%)
Query: 1722 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1781
A LP N+ KNR NI+PY++TRV L + SDYINAS+I G ++ YI TQGPL
Sbjct: 1651 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1710
Query: 1782 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 1841
T +DFW+M+WE N +VM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1711 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1769
Query: 1842 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 1901
+REFK+ + + R +R F +T WP+ GVP++ + I F+ V + GP
Sbjct: 1770 ILREFKVT-DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1828
Query: 1902 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 1961
VHCSAGVGRTG FI L +L+++ + VDI+ V LR R MVQTE QY + ++
Sbjct: 1829 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAAL 1888
Query: 1962 DVL 1964
+ L
Sbjct: 1889 EYL 1891
Score = 61.6 bits (148), Expect = 7e-09
Identities = 138/715 (19%), Positives = 271/715 (37%), Gaps = 126/715 (17%)
Query: 884 YKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAF 943
Y + ++ G ++ A I +P ++ + AT S+T+ W G + SY +
Sbjct: 287 YTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTAT-SITLTWDSGNPEPVSYYI--I 343
Query: 944 RHSQKVDSQTIPKHV-----FEHTFHRLEAGEQYQIMIASVSGSLKNQ-----INVVGRT 993
+H K +S+ + K + ++ L Y+ + +V+ + +
Sbjct: 344 QHKPK-NSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQ 402
Query: 994 VPASVQGVIADNAYSSYSLIVSWQKAA---GVAERYDILLLTE-----NGILLRNTSEPA 1045
P+S + SS +++V W++ G + Y + + N + N ++
Sbjct: 403 APSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQ 462
Query: 1046 TTKQHKFEDLTPGKKYKIQIL---TVSGGLFSKEAQTEGRT-VPAAVTDLRITENSTRHL 1101
T +L P K Y +++L ++ G S + Q +T VP + + S +
Sbjct: 463 ITT---IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 519
Query: 1102 SFRWTASEGE-LSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHS-- 1158
WT + ++ Y + + + ++R ++P S+ Q L +Y + S
Sbjct: 520 LLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGT-SYRLQGLKPNSLYYFRLAARSPQ 578
Query: 1159 GELSNESFIFGRTV---PASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTK 1215
G ++ + I RT+ P++ ++ S+ +W P + + Y+ T
Sbjct: 579 GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 638
Query: 1216 KENWKDK---------DLTEWRFQGLVPGRKYVLWVVTHSG------DLSNKVTAESRTA 1260
+ DK D T++ + L +Y + V H+ LS +
Sbjct: 639 VDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVP 698
Query: 1261 PSPPSLMSFADIANTSLAITW---------------------------KGPPDWTDYNDF 1293
PP + + +TS+ ++W KG P D
Sbjct: 699 SGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLA 758
Query: 1294 ELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVK--TVSGDSWKTYSKPI--FG 1349
+ QW +++ I+ GL+P SY V T GD ++ K + G
Sbjct: 759 DAQW----------EFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTG 808
Query: 1350 SVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDF---DGYSIECRKMDTQ---EVEFSRKL 1403
+V KP + N Q +TA+ W PP F GY ++ + D + +EFS K
Sbjct: 809 AVPGKPRLVIN---HTQMNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEK- 863
Query: 1404 EKEKSLLNIMMLVPHK--RYLVSIKVQS-AGMTSEVVEDSTITMIDRPPPPPPHIRVNEK 1460
E + +I HK Y+ + ++ G E+V++ +I P +
Sbjct: 864 EDHFTATDI-----HKGASYVFRLSARNKVGFGEEMVKEISI---------PEEVPTGFP 909
Query: 1461 DVLISKSSINFTVNCSW----FSDTNGAVKYFTVVVREADGSDELKPEQQHPLPS 1511
L S+ + + +V SW ++ NG + +T++ R D + L P +Q +P+
Sbjct: 910 QNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR--DINIPLLPMEQLIVPA 962
Score = 61.2 bits (147), Expect = 1e-08
Identities = 155/720 (21%), Positives = 256/720 (35%), Gaps = 115/720 (15%)
Query: 16 LLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCN----FSLIYSSDTLGAALCPTF 71
L QT P + SS ++ +QW+ P + + Y+ D PT
Sbjct: 396 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMD-------PTQ 448
Query: 72 RIDNTTYGCNLQDLQAGTI--------YNFRIIS--------LDEERTVVLQTD-PLPPA 114
++N N+ D Q TI Y+ ++++ L + V+ QT P P
Sbjct: 449 HVNNWMKH-NVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPL 507
Query: 115 RFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSW-------NE 167
F E TS L W P S + +YE+ D + + Q + I+ TS+ N
Sbjct: 508 NFKAEPESETSILLS-WTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNS 566
Query: 168 YTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIG-ISTKANSLLISW---- 222
+F L A S + + S T S +P +DI S + S+L+SW
Sbjct: 567 LYYFRLAARSPQGLGASTA-----EISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPP 621
Query: 223 -SHGSGNVERYRLMLM------DKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVM--TE 273
+G + Y + DK + G + T Y L Y +TV T+
Sbjct: 622 VEKQNGIITEYSIKYTAVDGEDDKPHEILG--IPSDTTKYLLEQLEKWTEYRITVTAHTD 679
Query: 274 AAGLQNYRWKLVRT------APMEVSNLKVTNDGSLTSLKVKWQRP-----PGNVDSYNI 322
L+RT P ++ N TS+KV W+ P G + Y +
Sbjct: 680 VGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNS---TSVKVSWRSPVPNKQHGQIRGYQV 736
Query: 323 --TLSHKGTIKESRVL-------APW-ITETHFKELVPGRLYQVTVSCVSGELSAQKMAV 372
G K +L A W +T +++ L T ++ K
Sbjct: 737 HYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDG 796
Query: 373 GRTFPDKVANLEA--------NNNGRMRSLVVSWSPPA---GDWEQYRILL-FNDSVVLL 420
R+ P V+ A N+ +M + ++ W PP G + YR+ D L
Sbjct: 797 ARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLT 856
Query: 421 NITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAV-----LQLRV 475
+ ++E + D + G Y + + E + ++P V L
Sbjct: 857 TLEFSEKEDHFTATD--IHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHS 914
Query: 476 KHANETSLSIMWQTPVAEWEKYII---SLADRD----LLLIHKSLSKDAKEFTFTDLVPG 528
+ TS+ + WQ PV II +L RD LL + + + T T L P
Sbjct: 915 EGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPD 974
Query: 529 RKYMATVT--SISGDLKNSSSVKGRTVPAQ---VTDLHVANQGMTSSLFTNWTQAQGDVE 583
Y V + G S SV+ RT+P + HV M +S+ +W +
Sbjct: 975 TTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHV-KAVMKTSVLLSWEIPENYNS 1033
Query: 584 FYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVP 643
+++++ + E + ++ +LK YS V+T Q V +T P
Sbjct: 1034 AMPFKILYDDGKMV-EEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAP 1092
Score = 50.4 bits (119), Expect = 2e-05
Identities = 76/362 (20%), Positives = 147/362 (40%), Gaps = 33/362 (9%)
Query: 950 DSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSS 1009
D I ++V E R A Y + S G ++ + + +P G ++
Sbjct: 267 DDMPIGRNVLELNDVRQSAN--YTCVAMSTLGVIEAIAQITVKALPKP-PGTPVVTESTA 323
Query: 1010 YSLIVSWQKAAGVAERYDILL-LTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTV 1068
S+ ++W Y I+ +N L + T ++ L+P Y+ +++ V
Sbjct: 324 TSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAV 383
Query: 1069 SG---GLFSKEA--QTEGRTVPAAVTDLRITENSTRHLSFRWTASE---GELSWYNIFLY 1120
+ G S+ QT + +A D++ S+ + +W E G++ Y ++ Y
Sbjct: 384 NNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVY-Y 442
Query: 1121 NPD-----GNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHS----GELSNESFIFGRT 1171
D N + D + + NL+ + Y + ++ + G LS++ + +T
Sbjct: 443 TMDPTQHVNNWMKHNVADSQITTIG--NLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQT 500
Query: 1172 -VPASVSHLRGSNRNTTDSLWFNWSPASGD-FDFYELILYNPNGTKKENWKDKDLTEWRF 1229
VP + + + T S+ +W+P D YEL+ + +++ + T +R
Sbjct: 501 GVPGQPLNFKAEPESET-SILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRL 559
Query: 1230 QGLVPGRKYVLWVVTHSGDLSNKVTAE--SRTAPS----PPSLMSFADIANTSLAITWKG 1283
QGL P Y + S TAE +RT S PP +S ++TS+ ++W+
Sbjct: 560 QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQP 619
Query: 1284 PP 1285
PP
Sbjct: 620 PP 621
Score = 50.4 bits (119), Expect = 2e-05
Identities = 137/713 (19%), Positives = 263/713 (36%), Gaps = 91/713 (12%)
Query: 796 YSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGD-VDQYEIQLL 854
Y+ + G EA Q + +P+P + + + +TW N + V Y IQ
Sbjct: 287 YTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHK 346
Query: 855 -FNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTIS----GDVQQSAFIE-GFTVPS 908
N +++ V T T Y L+P Y+ V+ ++ G + + PS
Sbjct: 347 PKNSEELYKEIDGVAT-TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPS 405
Query: 909 AVKNIHISPNGATDSLTVNWTPG---GGDVDSYTVSAFRHSQKVDSQTIPKHVFEH---T 962
+ + ++ ++ V W G + Y V + + + +V + T
Sbjct: 406 SAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT 465
Query: 963 FHRLEAGEQYQIMIASVS----GSLKNQINVVGRT-VPASVQGVIADNAYSSYSLIVSWQ 1017
L + Y + + + + G L + I V+ +T VP A+ S S+++SW
Sbjct: 466 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPE-SETSILLSWT 524
Query: 1018 KA-AGVAERYDILLLT-ENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSG-GLFS 1074
+ Y+++ E+G R T EP T+ ++ + L P Y ++ S GL +
Sbjct: 525 PPRSDTIANYELVYKDGEHGEEQRITIEPGTS--YRLQGLKPNSLYYFRLAARSPQGLGA 582
Query: 1075 KEAQTEGRTVP----AAVTDLRITENSTRHLSFRWTA-----SEGELSWYNIFLYNPDGN 1125
A+ RT+ A D+ T S+ + W G ++ Y+I DG
Sbjct: 583 STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 642
Query: 1126 LQERAQVDPL---VQSFSFQNLLQGRMYKMVIVTHS--GELSNESFIFGRT---VPASVS 1177
+ ++ + + + L + Y++ + H+ G + RT VP+
Sbjct: 643 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPP 702
Query: 1178 HLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKENWKDKDL----------TEW 1227
+ S+ +W + ++ Y + + EN + K +W
Sbjct: 703 RKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQW 762
Query: 1228 RFQ----------GLVPGRKYVLWVVTHS--GDLSN---KVTAESRTAPSPPSLMSFADI 1272
F GL P Y L V ++ GD + K+ + + P P L+
Sbjct: 763 EFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQ 822
Query: 1273 ANTSLAITWKGPPD-WTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFN 1331
NT+L I W P D + + L++ +D + + K + + G SY F
Sbjct: 823 MNTAL-IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFR 881
Query: 1332 VKTVSGDSWKTYSKPIFGSVRTK----PDKI-----QNLHCRPQNSTAIACSWIPP---- 1378
+ +K FG K P+++ QNLH ST++ SW PP
Sbjct: 882 LSA--------RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAE 933
Query: 1379 -DSDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSA 1430
+ Y++ R ++ + + + + + + L P Y V ++ ++
Sbjct: 934 RNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTS 986
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 246 bits (627), Expect = 2e-64
Identities = 213/739 (28%), Positives = 340/739 (46%), Gaps = 105/739 (14%)
Query: 1274 NTSLAITWKGPPDWTD-----------YNDFELQWLPRDALTVFNPYNNRKSEGRIVYGL 1322
+TS+ ++W+ PP + Y D + LP + L V P + + + GL
Sbjct: 923 STSVQLSWQ-PPVLAERNGIITKYTLLYRDINIPLLPMEQLIV--PADTTMT----LTGL 975
Query: 1323 RPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKP-DKI--QNLHCRPQNSTAIACSWIPPD 1379
+P +Y V+ + YS + RT P D++ +N H + T++ SW P+
Sbjct: 976 KPDTTYDVKVRAHTSKGPGPYSPSV--QFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPE 1033
Query: 1380 SDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRY--LVSIKVQSAGMTSEVV 1437
+ + D + VE +K ++N L P K Y +++ + SAG V
Sbjct: 1034 NYNSAMPFKILYDDGKMVEEVDGRATQKLIVN---LKPEKSYSFVLTNRGNSAGGLQHRV 1090
Query: 1438 EDSTITMIDRPPPPPPHIRVNEKDVLISKSSIN--FTVNCSWFSDTNGAVKYFTVVV--R 1493
T + R P I K++++ TV Y+ ++V +
Sbjct: 1091 TAKTAPDVLRTKP-----------AFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLK 1139
Query: 1494 EADGS-------------DELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSN 1540
++ G DEL E S + Y ++ Y +F E +
Sbjct: 1140 KSRGKFIKPWESPDEMELDELLKEISRKRRS-IRYGREVELKPYIAAHFDVLPTEFTLGD 1198
Query: 1541 SKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLY 1600
K + GG F + L+ Y + A + + K + Y
Sbjct: 1199 DKHY-----------GG--------FTNKQLQSGQEYVFFVLAVME--HAESKMYATSPY 1237
Query: 1601 SDTFFSL-----PITTESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSA 1655
SD S+ PIT E E L + V A +F+I +++A+ LL R++ E S
Sbjct: 1238 SDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAI--LLYKRKRA----ESDSR 1291
Query: 1656 RLSIRRDRPLSVH----------LNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSK 1705
+ SI ++ + H LN G + PI I + H +L+A+ N S+
Sbjct: 1292 KSSIPNNKEIPSHHPTDPVELRRLNFQTPG-MASHPPIPILELADHIERLKANDNLKFSQ 1350
Query: 1706 EYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPG 1765
EYE + D G+ + + + L N+ KNRY N++ YD +RV LS ++ P SDY+NA+YI G
Sbjct: 1351 EYESI-DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG 1409
Query: 1766 NNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYY 1825
+ YI TQG LP T DFW+M+WEQ +VM+T+ E+ RVKCD YWP+ + + +
Sbjct: 1410 YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPS-RGTETH 1468
Query: 1826 GDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVR 1885
G + + +L L + +R F + + R +R F +T WPDHGVPE + F+R
Sbjct: 1469 GLVQVTLLDTVELATYCVRTFALY-KNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLR 1527
Query: 1886 TVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVH 1945
V+ P AGP VVHCSAGVGRTG FI +D +L+++ + +VDIYG V +R R +
Sbjct: 1528 RVKTC--NPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNY 1585
Query: 1946 MVQTECQYVYLHQCVRDVL 1964
MVQTE QY+++H + + +
Sbjct: 1586 MVQTEDQYIFIHDALLEAV 1604
Score = 194 bits (493), Expect = 7e-49
Identities = 103/243 (42%), Positives = 148/243 (60%), Gaps = 2/243 (0%)
Query: 1722 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1781
A LP N+ KNR NI+PY++TRV L + SDYINAS+I G ++ YI TQGPL
Sbjct: 1655 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1714
Query: 1782 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 1841
T +DFW+M+WE N +VM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1715 TTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1773
Query: 1842 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 1901
+REFK+ + + R +R F +T WP+ GVP++ + I F+ V + GP
Sbjct: 1774 ILREFKVT-DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1832
Query: 1902 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 1961
VHCSAGVGRTG FI L +L+++ + VDI+ V LR R MVQTE QY + ++
Sbjct: 1833 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAAL 1892
Query: 1962 DVL 1964
+ L
Sbjct: 1893 EYL 1895
Score = 63.5 bits (153), Expect = 2e-09
Identities = 155/712 (21%), Positives = 253/712 (35%), Gaps = 108/712 (15%)
Query: 16 LLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCN----FSLIYSSDTLGAALCPTF 71
L QT P + SS ++ +QW+ P + + Y+ D PT
Sbjct: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMD-------PTQ 461
Query: 72 RIDNTTYGCNLQDLQAGTI--------YNFRIIS--------LDEERTVVLQTD-PLPPA 114
++N N+ D Q TI Y+ ++++ L + V+ QT P P
Sbjct: 462 HVNNWMKH-NVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPL 520
Query: 115 RFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSW-------NE 167
F E TS L W P S + +YE+ D + + Q + I+ TS+ N
Sbjct: 521 NFKAEPESETSILLS-WTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNS 579
Query: 168 YTFFNLTAGSKYNIAITAVSGGKRSFSVYTNGSTVPSPVKDIG-ISTKANSLLISW---- 222
+F L A S + + S T S +P +DI S + S+L+SW
Sbjct: 580 LYYFRLAARSPQGLGASTA-----EISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPP 634
Query: 223 -SHGSGNVERYRLMLM------DKGILVHGGVVDKHATSYAFHGLTPGYLYNLTVM--TE 273
+G + Y + DK + G + T Y L Y +TV T+
Sbjct: 635 VEKQNGIITEYSIKYTAVDGEDDKPHEILG--IPSDTTKYLLEQLEKWTEYRITVTAHTD 692
Query: 274 AAGLQNYRWKLVRT------APMEVSNLKVTNDGSLTSLKVKWQRP-----PGNVDSYNI 322
L+RT P ++ N TS+KV W+ P G + Y +
Sbjct: 693 VGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNS---TSVKVSWRSPVPNKQHGQIRGYQV 749
Query: 323 TL------SHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVS----GELSAQKMAV 372
KG V+ + L P Y +TV+ + G S K+ V
Sbjct: 750 HYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKL-V 808
Query: 373 GRTFPDKVANLEANNNGRMRSLVVSWSPPA---GDWEQYRILL-FNDSVVLLNITVGKEE 428
T N+ +M + ++ W PP G + YR+ D L + ++E
Sbjct: 809 STTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKE 868
Query: 429 TQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAV-----LQLRVKHANETSL 483
+ D + G Y + + E + ++P V L + TS+
Sbjct: 869 DHFTATD--IHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSV 926
Query: 484 SIMWQTPVAEWEKYII---SLADRD----LLLIHKSLSKDAKEFTFTDLVPGRKYMATVT 536
+ WQ PV II +L RD LL + + + T T L P Y V
Sbjct: 927 QLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVR 986
Query: 537 --SISGDLKNSSSVKGRTVPAQ---VTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIH 591
+ G S SV+ RT+P + HV M +S+ +W + +++
Sbjct: 987 AHTSKGPGPYSPSVQFRTLPVDQVFAKNFHV-KAVMKTSVLLSWEIPENYNSAMPFKILY 1045
Query: 592 ENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVP 643
++ + E + ++ +LK YS V+T Q V +T P
Sbjct: 1046 DDGKMV-EEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAP 1096
Score = 58.2 bits (139), Expect = 8e-08
Identities = 82/345 (23%), Positives = 137/345 (39%), Gaps = 29/345 (8%)
Query: 1185 NTTDSLWFNWSPASGDFDFYELILYNPNGTKKENWKDKD---LTEWRFQGLVPGRKYVLW 1241
+T S+ W + + Y +I + P ++ E +K+ D T + GL P Y
Sbjct: 334 STATSITLTWDSGNPEPVSYYIIQHKPKNSE-ELYKEIDGVATTRYSVAGLSPYSDYEFR 392
Query: 1242 VVTHS----GDLSNKV-TAESRTAPSP-PSLMSFADIANTSLAITWKGPPDWT-DYNDFE 1294
VV + G S V T S APS P + +++T++ + WK P + +
Sbjct: 393 VVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYR 452
Query: 1295 LQWL--PRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVR 1352
+ + P + + +N S+ + L P ++Y V + S I +
Sbjct: 453 VYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQ 512
Query: 1353 TK-PDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKEKSLLN 1411
T P + N P++ T+I SW PP SD + E D + E R + +
Sbjct: 513 TGVPGQPLNFKAEPESETSILLSWTPPRSDTIA-NYELVYKDGEHGEEQRITIEPGTSYR 571
Query: 1412 IMMLVPHKRYLVSIKVQS-AGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSIN 1470
+ L P+ Y + +S G+ + E S TM +P PP I S SS +
Sbjct: 572 LQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT------SPSSTS 625
Query: 1471 FTVNCSW----FSDTNGAVKYFTVVVREADGSDELKPEQQHPLPS 1511
V SW NG + +++ DG D+ KP + +PS
Sbjct: 626 ILV--SWQPPPVEKQNGIITEYSIKYTAVDGEDD-KPHEILGIPS 667
Score = 52.8 bits (125), Expect = 3e-06
Identities = 136/704 (19%), Positives = 262/704 (37%), Gaps = 82/704 (11%)
Query: 796 YSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWSGANGD-VDQYEIQLL 854
Y+ + G EA Q + +P+P + + + +TW N + V Y IQ
Sbjct: 300 YTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHK 359
Query: 855 -FNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTIS----GDVQQSAFIE-GFTVPS 908
N +++ V T T Y L+P Y+ V+ ++ G + + PS
Sbjct: 360 PKNSEELYKEIDGVAT-TRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPS 418
Query: 909 AVKNIHISPNGATDSLTVNWTPG---GGDVDSYTVSAFRHSQKVDSQTIPKHVFEH---T 962
+ + ++ ++ V W G + Y V + + + +V + T
Sbjct: 419 SAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT 478
Query: 963 FHRLEAGEQYQIMIASVS----GSLKNQINVVGRT-VPASVQGVIADNAYSSYSLIVSWQ 1017
L + Y + + + + G L + I V+ +T VP A+ S S+++SW
Sbjct: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPE-SETSILLSWT 537
Query: 1018 KA-AGVAERYDILLLT-ENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSG-GLFS 1074
+ Y+++ E+G R T EP T+ ++ + L P Y ++ S GL +
Sbjct: 538 PPRSDTIANYELVYKDGEHGEEQRITIEPGTS--YRLQGLKPNSLYYFRLAARSPQGLGA 595
Query: 1075 KEAQTEGRTVP----AAVTDLRITENSTRHLSFRWTA-----SEGELSWYNIFLYNPDGN 1125
A+ RT+ A D+ T S+ + W G ++ Y+I DG
Sbjct: 596 STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 655
Query: 1126 LQERAQVDPL---VQSFSFQNLLQGRMYKMVIVTHS--GELSNESFIFGRT---VPASVS 1177
+ ++ + + + L + Y++ + H+ G + RT VP+
Sbjct: 656 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPP 715
Query: 1178 HLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNGTKKENWKDK-----------DLTE 1226
+ S+ +W + ++ Y + + EN + K D +
Sbjct: 716 RKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQD 775
Query: 1227 WRFQGLVPGRKYVLWVVTHS--GDLSN---KVTAESRTAPSPPSLMSFADIANTSLAITW 1281
GL P Y L V ++ GD + K+ + + P P L+ NT+L I W
Sbjct: 776 MIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL-IQW 834
Query: 1282 KGPPD-WTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSW 1340
P D + + L++ +D + + K + + G SY F +
Sbjct: 835 HPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSA------ 888
Query: 1341 KTYSKPIFGSVRTK----PDKI-----QNLHCRPQNSTAIACSWIPP-----DSDFDGYS 1386
+K FG K P+++ QNLH ST++ SW PP + Y+
Sbjct: 889 --RNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYT 946
Query: 1387 IECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSA 1430
+ R ++ + + + + + + L P Y V ++ ++
Sbjct: 947 LLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTS 990
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 245 bits (625), Expect = 4e-64
Identities = 129/278 (46%), Positives = 176/278 (63%), Gaps = 6/278 (2%)
Query: 1683 IKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDAT 1742
I++ H +++ Y +EYE L + G+ S D A ENR KNRY NI+ YD +
Sbjct: 869 IRVADLLQHITQMKRGQGYGFKEEYEALPE-GQTASWDTAKEDENRNKNRYGNIISYDHS 927
Query: 1743 RVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVT 1802
RV+L +D DP SDYINA+YI G + R YI TQGP+ T DFW+M+W++N +IVMVT
Sbjct: 928 RVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT 987
Query: 1803 QCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRH 1862
VE GRVKC YWP D + YGD+ + ++ L E+ IR F + ++ R +R
Sbjct: 988 NLVEVGRVKCVRYWPDDTE--VYGDIKVTLIETEPLAEYVIRTFTV-QKKGYHEIRELRL 1044
Query: 1863 FHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQ 1922
FH+T WPDHGVP L+ FVR V+ ++N P AGP VVHCSAG GRTG FIA+D +L
Sbjct: 1045 FHFTSWPDHGVPCYATGLLGFVRQVK-FLN-PPEAGPIVVHCSAGAGRTGCFIAIDTMLD 1102
Query: 1923 QLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 1960
+++ VDI+ V +LR RV++VQTE QYV++H +
Sbjct: 1103 MAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1140
Score = 142 bits (357), Expect = 4e-33
Identities = 82/253 (32%), Positives = 145/253 (57%), Gaps = 7/253 (2%)
Query: 1715 RNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIV 1774
R + C I LLP N KNR ++LP D L +VD + S+YINA+ + + ++V
Sbjct: 1190 RPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVV 1248
Query: 1775 TQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLS 1834
TQ PLP T DFW++V++ N ++VM+ + ++ + C YWP ++ S YG + ++ +S
Sbjct: 1249 TQHPLPNTVADFWRLVFDYNCSSVVMLNE-MDTAQF-CMQYWP-EKTSGCYGPIQVEFVS 1305
Query: 1835 ESVLPEWTIREFKICGEEQ-LDAHRLIRHFHYTVWPDH-GVPETTQSLIQFVRTVRDYIN 1892
+ + R F+IC + D +R+++H Y WP + P + +SL++ VR + +
Sbjct: 1306 ADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQE 1365
Query: 1893 RSPGA-GPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTEC 1951
+ G G TVVHC G GR+GTF A+ + + + ++ +D++ V LR ++ +MV+T
Sbjct: 1366 QYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLE 1425
Query: 1952 QYVYLHQCVRDVL 1964
QY ++++ + L
Sbjct: 1426 QYKFVYEVALEYL 1438
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 245 bits (625), Expect = 4e-64
Identities = 129/278 (46%), Positives = 176/278 (63%), Gaps = 6/278 (2%)
Query: 1683 IKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDAT 1742
I++ H +++ Y +EYE L + G+ S D A ENR KNRY NI+ YD +
Sbjct: 888 IRVADLLQHITQMKRGQGYGFKEEYEALPE-GQTASWDTAKEDENRNKNRYGNIISYDHS 946
Query: 1743 RVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVT 1802
RV+L +D DP SDYINA+YI G + R YI TQGP+ T DFW+M+W++N +IVMVT
Sbjct: 947 RVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT 1006
Query: 1803 QCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRH 1862
VE GRVKC YWP D + YGD+ + ++ L E+ IR F + ++ R +R
Sbjct: 1007 NLVEVGRVKCVRYWPDDTE--VYGDIKVTLIETEPLAEYVIRTFTV-QKKGYHEIRELRL 1063
Query: 1863 FHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQ 1922
FH+T WPDHGVP L+ FVR V+ ++N P AGP VVHCSAG GRTG FIA+D +L
Sbjct: 1064 FHFTSWPDHGVPCYATGLLGFVRQVK-FLN-PPEAGPIVVHCSAGAGRTGCFIAIDTMLD 1121
Query: 1923 QLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 1960
+++ VDI+ V +LR RV++VQTE QYV++H +
Sbjct: 1122 MAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1159
Score = 142 bits (357), Expect = 4e-33
Identities = 82/253 (32%), Positives = 145/253 (57%), Gaps = 7/253 (2%)
Query: 1715 RNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIV 1774
R + C I LLP N KNR ++LP D L +VD + S+YINA+ + + ++V
Sbjct: 1209 RPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVV 1267
Query: 1775 TQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLS 1834
TQ PLP T DFW++V++ N ++VM+ + ++ + C YWP ++ S YG + ++ +S
Sbjct: 1268 TQHPLPNTVADFWRLVFDYNCSSVVMLNE-MDTAQF-CMQYWP-EKTSGCYGPIQVEFVS 1324
Query: 1835 ESVLPEWTIREFKICGEEQ-LDAHRLIRHFHYTVWPDH-GVPETTQSLIQFVRTVRDYIN 1892
+ + R F+IC + D +R+++H Y WP + P + +SL++ VR + +
Sbjct: 1325 ADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQE 1384
Query: 1893 RSPGA-GPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTEC 1951
+ G G TVVHC G GR+GTF A+ + + + ++ +D++ V LR ++ +MV+T
Sbjct: 1385 QYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLE 1444
Query: 1952 QYVYLHQCVRDVL 1964
QY ++++ + L
Sbjct: 1445 QYKFVYEVALEYL 1457
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 243 bits (620), Expect = 1e-63
Identities = 218/779 (27%), Positives = 345/779 (44%), Gaps = 86/779 (11%)
Query: 1222 KDLTEWRFQGLVPGRKYVLWVVTHS-GDLSNKVTAESRTAPSPPS----LMSFADIANTS 1276
KD + GL G Y+ + + L + E RT PS + + ++
Sbjct: 872 KDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTST 931
Query: 1277 LAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI-------VYGLRPGRSYQ 1329
+ W PP + N + + VF N+++ I + GL+P +Y
Sbjct: 932 TELAWD-PPVLAERNGRIISYT-----VVFRDINSQQELQNITTDTRFTLTGLKPDTTYD 985
Query: 1330 FNVKTVSGDSWKTYSKPIFGSVRTKPDKIQ-----NLHCRPQNSTAIACSWIPPDSD--- 1381
V+ + S P+ S++++ ++ N T++ SW PDS
Sbjct: 986 IKVRAWTSKG----SGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSA 1041
Query: 1382 ------FDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRY--LVSIKVQSAGMT 1433
++G S+E + RKL I L P+ Y ++ + SAG
Sbjct: 1042 VPFKILYNGQSVEV------DGHSMRKL--------IADLQPNTEYSFVLMNRGSSAGGL 1087
Query: 1434 SEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVR 1493
+V T + P P + + +S + WF Y VV
Sbjct: 1088 QHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWF--------YIVVVPI 1139
Query: 1494 EADGSDELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEME 1553
+ G L P P L+ A + + + AE + + + E
Sbjct: 1140 DRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAA-QLDVLPETF 1198
Query: 1554 SLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFS--LPITT 1611
+LG K + F + PL P +Y+ + A + D K + YSD P
Sbjct: 1199 TLGDK--KNYRGFYNRPLSPDLSYQCFVLASLKE-PMDQKRYASSPYSDEIVVQVTPAQQ 1255
Query: 1612 ESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSAR----------LSIRR 1661
+ EP + G + LI ++ V+A+L+ ++K +H PS++ L
Sbjct: 1256 QEEPEMLWVTGPVLAVILI--ILIVIAILLFKRKRTHS---PSSKDEQSIGLKDSLLAHS 1310
Query: 1662 DRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDI 1721
P+ + Q + PI I + +L+A+ S+EYE + D G+ + +
Sbjct: 1311 SDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESI-DPGQQFTWEN 1369
Query: 1722 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1781
+ L N+ KNRY N++ YD +RV L+++D P SDYINA+YI G + YI TQGPLP
Sbjct: 1370 SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPE 1429
Query: 1782 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 1841
T DFW+MVWEQ +VM+T+ EK RVKCD YWPA + + G + + +L L +
Sbjct: 1430 TMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPA-RGTETCGLIQVTLLDTVELATY 1488
Query: 1842 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 1901
T+R F + + R +R F + WPDHGVPE ++ F+R V+ AGP V
Sbjct: 1489 TVRTFAL-HKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVK--ACNPLDAGPMV 1545
Query: 1902 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 1960
VHCSAGVGRTG FI +D +L+++ + +VDIYG V +R R +MVQTE QYV++H+ +
Sbjct: 1546 VHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL 1604
Score = 192 bits (489), Expect = 2e-48
Identities = 103/243 (42%), Positives = 146/243 (60%), Gaps = 2/243 (0%)
Query: 1722 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1781
A LP N+ KNR NI+PY+ TRV L + SDYINAS++ G ++ YI TQGPL
Sbjct: 1659 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1718
Query: 1782 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 1841
+ +DFW+M+WE N IVM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1719 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1777
Query: 1842 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 1901
+REFK+ + + R IR F +T WP+ GVP+T + I F+ V + GP
Sbjct: 1778 ILREFKVT-DARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPIT 1836
Query: 1902 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 1961
VHCSAGVGRTG FI L +L+++ + VD++ V LR R MVQTE QY ++
Sbjct: 1837 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAAL 1896
Query: 1962 DVL 1964
+ L
Sbjct: 1897 EYL 1899
Score = 50.1 bits (118), Expect = 2e-05
Identities = 134/695 (19%), Positives = 244/695 (35%), Gaps = 86/695 (12%)
Query: 778 IPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHV 837
+P N +V Y+ + G EA Q + +P+P DL + + + +
Sbjct: 278 MPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTL 337
Query: 838 TWSGANGD-VDQYEIQLLFNDMKVFPPFHLVN--TATEYRFTSLTPGRQYKILVLTIS-- 892
TW N + V Y IQ + PF V+ T Y L+P +Y VL ++
Sbjct: 338 TWDSGNSEPVTYYGIQ--YRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSI 395
Query: 893 GDVQQSAFIE---GFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKV 949
G S + G PS+ + + ++ V W P + + V +R
Sbjct: 396 GRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP--PEEPNGLVRGYRVYYTP 453
Query: 950 DSQTIPKHVFEH--------TFHRLEAGEQYQIMIASVSG----------SLKNQINVVG 991
DS+ P +H T L G Y + + + + +K Q V
Sbjct: 454 DSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPA 513
Query: 992 RTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTSEPATTKQHK 1051
+ PA Q + + S ++ Q+ + Y+++ ++ T +
Sbjct: 514 Q--PADFQAEVESDTRIQLSWLLPPQERIIM---YELVYWAAEDEDQQHKVTFDPTSSYT 568
Query: 1052 FEDLTPGKKYKIQILTVSG---GLFSK--EAQTEGRTVPAAVTDLRITENSTRHLSFRWT 1106
EDL P Y+ Q+ S G+F+ EA+T T A + + + W
Sbjct: 569 LEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
Query: 1107 -----ASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLL---QGRMYKMVIVTHS 1158
+ G ++ Y++ DG + R VD + + S +L+ + Y++ + H+
Sbjct: 629 PPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT 688
Query: 1159 --GELSNESFIFGRT---VPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNG 1213
G S + RT VP+ + ++ W ++ Y
Sbjct: 689 DVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTY 748
Query: 1214 TKKENWKDKDL----------TEWR----------FQGLVPGRKYVLWVV--THSGDLSN 1251
+ EN + + L +WR GL P Y + V T GD +
Sbjct: 749 VRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGAR 808
Query: 1252 ---KVTAESRTAPSPPSLMSFADIANTSLAITWKGPPDWT-DYNDFELQWLPRDALTVFN 1307
K+ + P P++M NT+L + W P + + + LQ+ D
Sbjct: 809 SKPKIVTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARPNT 867
Query: 1308 PYNNRKSEGRIVYGLRPGRSYQFNVKTVS-GDSWKTYSKPIFGSVRTKPDKIQNLHCRPQ 1366
+ + V GL G +Y F + + + + K I QNLH
Sbjct: 868 IDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGL 927
Query: 1367 NSTAIACSWIPP-----DSDFDGYSIECRKMDTQE 1396
++ +W PP + Y++ R +++Q+
Sbjct: 928 TTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQ 962
Score = 48.5 bits (114), Expect = 6e-05
Identities = 133/693 (19%), Positives = 256/693 (36%), Gaps = 97/693 (13%)
Query: 884 YKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAF 943
Y + ++ G ++ +A + +P ++ ++ AT S+T+ W G + +Y +
Sbjct: 296 YTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTAT-SVTLTWDSGNSEPVTYYGIQY 354
Query: 944 RHS------QKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVS----GSLKNQINV-VGR 992
R + Q+VD ++ + L +Y + +V+ G + G
Sbjct: 355 RAAGTEGPFQEVDGVATTRY----SIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGE 410
Query: 993 TVPASVQGVIADNAYSSYSLIVSWQ---KAAGVAERYDILLLTE-----NGILLRNTSEP 1044
P+S + S+ +++V W+ + G+ Y + + N NT
Sbjct: 411 QAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAG 470
Query: 1045 ATTKQHKFEDLTPGKKYKIQILT---VSGGLFSKEAQTEGRT-VPAAVTDLRITENSTRH 1100
T L PG Y +++L V G S Q + + VPA D + S
Sbjct: 471 LLTT---VGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTR 527
Query: 1101 LSFRWTASEGE--LSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHS 1158
+ W E + + ++ D + Q + DP S++ ++L +Y+ + S
Sbjct: 528 IQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDP-TSSYTLEDLKPDTLYRFQLAARS 586
Query: 1159 --GELSNESFIFGRTVPASVSH-----LRGSNRNTTDSLWFNWSPASGDFD--------- 1202
G I RT ++ S + S +TT + +W P D
Sbjct: 587 DMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRV--SWVPPPADSRNGVITQYSV 644
Query: 1203 FYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHS----GDLSNKVTAES- 1257
YE + G + ++ + W GL +Y +WV H+ G S+ V +
Sbjct: 645 AYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTD 704
Query: 1258 RTAPS-PPSLMSFADIANTSLAITWKGPPDWTDYNDF-------------ELQWLP--RD 1301
PS PP + + +T++ + WK P + E + LP +D
Sbjct: 705 EDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQD 764
Query: 1302 ALTVFNPYNNRKSEG--RIVYGLRPGRSYQFNVK--TVSGDSWKTYSKPIF--GSVRTKP 1355
+ + +SE + GL P +Y V T GD ++ K + G+V +P
Sbjct: 765 VMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRP 824
Query: 1356 DKIQNLHCRPQNSTAIACSWIPPDS---DFDGYSIE-CRKMDTQE--VEFSRKLEKEKSL 1409
+ + N+ + W PP + GY ++ CR + + ++F K+
Sbjct: 825 TMM--ISTTAMNTALL--QWHPPKELPGELLGYRLQYCRADEARPNTIDFG----KDDQH 876
Query: 1410 LNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSI 1469
+ L Y+ + ++ E E T D P P ++ V ++ S+
Sbjct: 877 FTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTG----LTTSTT 932
Query: 1470 NFTVNCSWFSDTNGAVKYFTVVVREADGSDELK 1502
+ ++ NG + +TVV R+ + EL+
Sbjct: 933 ELAWDPPVLAERNGRIISYTVVFRDINSQQELQ 965
Score = 44.7 bits (104), Expect = 0.001
Identities = 90/353 (25%), Positives = 137/353 (38%), Gaps = 63/353 (17%)
Query: 100 EERTVVLQTD---PLPPARFGVSKEKTTSTSLHVWW---TPSS--GKVTSYEVQLFDENN 151
E V+++TD P P R V E ST++HV+W PS G++ Y+V N
Sbjct: 695 ESSPVLVRTDEDVPSGPPR-KVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLEN 753
Query: 152 QKIQGVQI------------QESTSWNEYTFFNLTAGSKYNIAITAVS----GGKRSFSV 195
+ +G+ I E + E T LT + Y++ + A + G + +
Sbjct: 754 GEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKI 813
Query: 196 YTNGSTVPSPVKDIGISTKANSLLISW---SHGSGNVERYRLMLM----DKGILVHGGVV 248
T VP + +T N+ L+ W G + YRL + + G
Sbjct: 814 VTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKD 873
Query: 249 DKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEV-----SNLKVTNDGSL 303
D+H T H T Y++ L AGL K +RT P ++ NL VT +
Sbjct: 874 DQHFTVTGLHKGTT-YIFRLAAKNR-AGLGEEFEKEIRT-PEDLPSGFPQNLHVTGLTTS 930
Query: 304 TSLKVKWQRP-----PGNVDSYNITLSHKGTIKESRVLAPWITETHF--KELVPGRLYQV 356
T+ ++ W P G + SY + I + L T+T F L P Y +
Sbjct: 931 TT-ELAWDPPVLAERNGRIISYTVVFR---DINSQQELQNITTDTRFTLTGLKPDTTYDI 986
Query: 357 TV----SCVSGELSAQKMAVGRTFPDKVANLEANN----NGRMRSLVVSWSPP 401
V S SG LS + RT P V + A N S+++SW P
Sbjct: 987 KVRAWTSKGSGPLSPSIQS--RTMP--VEQVFAKNFRVAAAMKTSVLLSWEVP 1035
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 243 bits (620), Expect = 1e-63
Identities = 218/779 (27%), Positives = 345/779 (44%), Gaps = 86/779 (11%)
Query: 1222 KDLTEWRFQGLVPGRKYVLWVVTHS-GDLSNKVTAESRTAPSPPS----LMSFADIANTS 1276
KD + GL G Y+ + + L + E RT PS + + ++
Sbjct: 863 KDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTST 922
Query: 1277 LAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI-------VYGLRPGRSYQ 1329
+ W PP + N + + VF N+++ I + GL+P +Y
Sbjct: 923 TELAWD-PPVLAERNGRIISYT-----VVFRDINSQQELQNITTDTRFTLTGLKPDTTYD 976
Query: 1330 FNVKTVSGDSWKTYSKPIFGSVRTKPDKIQ-----NLHCRPQNSTAIACSWIPPDSD--- 1381
V+ + S P+ S++++ ++ N T++ SW PDS
Sbjct: 977 IKVRAWTSKG----SGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSA 1032
Query: 1382 ------FDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRY--LVSIKVQSAGMT 1433
++G S+E + RKL I L P+ Y ++ + SAG
Sbjct: 1033 VPFKILYNGQSVEV------DGHSMRKL--------IADLQPNTEYSFVLMNRGSSAGGL 1078
Query: 1434 SEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVR 1493
+V T + P P + + +S + WF Y VV
Sbjct: 1079 QHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWF--------YIVVVPI 1130
Query: 1494 EADGSDELKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEME 1553
+ G L P P L+ A + + + AE + + + E
Sbjct: 1131 DRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAA-QLDVLPETF 1189
Query: 1554 SLGGKCDPTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFS--LPITT 1611
+LG K + F + PL P +Y+ + A + D K + YSD P
Sbjct: 1190 TLGDK--KNYRGFYNRPLSPDLSYQCFVLASLKE-PMDQKRYASSPYSDEIVVQVTPAQQ 1246
Query: 1612 ESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSAR----------LSIRR 1661
+ EP + G + LI ++ V+A+L+ ++K +H PS++ L
Sbjct: 1247 QEEPEMLWVTGPVLAVILI--ILIVIAILLFKRKRTHS---PSSKDEQSIGLKDSLLAHS 1301
Query: 1662 DRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDI 1721
P+ + Q + PI I + +L+A+ S+EYE + D G+ + +
Sbjct: 1302 SDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESI-DPGQQFTWEN 1360
Query: 1722 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1781
+ L N+ KNRY N++ YD +RV L+++D P SDYINA+YI G + YI TQGPLP
Sbjct: 1361 SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPE 1420
Query: 1782 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 1841
T DFW+MVWEQ +VM+T+ EK RVKCD YWPA + + G + + +L L +
Sbjct: 1421 TMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPA-RGTETCGLIQVTLLDTVELATY 1479
Query: 1842 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 1901
T+R F + + R +R F + WPDHGVPE ++ F+R V+ AGP V
Sbjct: 1480 TVRTFAL-HKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVK--ACNPLDAGPMV 1536
Query: 1902 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 1960
VHCSAGVGRTG FI +D +L+++ + +VDIYG V +R R +MVQTE QYV++H+ +
Sbjct: 1537 VHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL 1595
Score = 192 bits (489), Expect = 2e-48
Identities = 103/243 (42%), Positives = 146/243 (60%), Gaps = 2/243 (0%)
Query: 1722 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1781
A LP N+ KNR NI+PY+ TRV L + SDYINAS++ G ++ YI TQGPL
Sbjct: 1650 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1709
Query: 1782 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 1841
+ +DFW+M+WE N IVM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1710 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1768
Query: 1842 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 1901
+REFK+ + + R IR F +T WP+ GVP+T + I F+ V + GP
Sbjct: 1769 ILREFKVT-DARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPIT 1827
Query: 1902 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 1961
VHCSAGVGRTG FI L +L+++ + VD++ V LR R MVQTE QY ++
Sbjct: 1828 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAAL 1887
Query: 1962 DVL 1964
+ L
Sbjct: 1888 EYL 1890
Score = 51.2 bits (121), Expect = 1e-05
Identities = 133/686 (19%), Positives = 242/686 (35%), Gaps = 77/686 (11%)
Query: 778 IPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHV 837
+P N +V Y+ + G EA Q + +P+P DL + + + +
Sbjct: 278 MPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTL 337
Query: 838 TWSGANGD-VDQYEIQLLFNDMKVFPPFHLVN--TATEYRFTSLTPGRQYKILVLTIS-- 892
TW N + V Y IQ + PF V+ T Y L+P +Y VL ++
Sbjct: 338 TWDSGNSEPVTYYGIQ--YRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSI 395
Query: 893 GDVQQSAFIE---GFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKV 949
G S + G PS+ + + ++ V W P + + V +R
Sbjct: 396 GRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP--PEEPNGLVRGYRVYYTP 453
Query: 950 DSQTIPKHVFEH--------TFHRLEAGEQYQIMIASVSG----------SLKNQINVVG 991
DS+ P +H T L G Y + + + + +K Q V
Sbjct: 454 DSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPA 513
Query: 992 RTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTSEPATTKQHK 1051
+ PA Q + + S ++ Q+ + Y+++ ++ T +
Sbjct: 514 Q--PADFQAEVESDTRIQLSWLLPPQERIIM---YELVYWAAEDEDQQHKVTFDPTSSYT 568
Query: 1052 FEDLTPGKKYKIQILTVSG---GLFSK--EAQTEGRTVPAAVTDLRITENSTRHLSFRWT 1106
EDL P Y+ Q+ S G+F+ EA+T T A + + + W
Sbjct: 569 LEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
Query: 1107 -----ASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLL---QGRMYKMVIVTHS 1158
+ G ++ Y++ DG + R VD + + S +L+ + Y++ + H+
Sbjct: 629 PPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT 688
Query: 1159 --GELSNESFIFGRT---VPASVSHLRGSNRNTTDSLWFNWSPASGDFDFYELILYNPNG 1213
G S + RT VP+ + ++ W ++ Y
Sbjct: 689 DVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTY 748
Query: 1214 TKKENWKDKDL-----------TEWRFQGLVPGRKYVLWVV--THSGDLSN---KVTAES 1257
+ EN + + L E GL P Y + V T GD + K+ +
Sbjct: 749 VRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTT 808
Query: 1258 RTAPSPPSLMSFADIANTSLAITWKGPPDWT-DYNDFELQWLPRDALTVFNPYNNRKSEG 1316
P P++M NT+L + W P + + + LQ+ D + +
Sbjct: 809 GAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQH 867
Query: 1317 RIVYGLRPGRSYQFNVKTVS-GDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSW 1375
V GL G +Y F + + + + K I QNLH ++ +W
Sbjct: 868 FTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAW 927
Query: 1376 IPP-----DSDFDGYSIECRKMDTQE 1396
PP + Y++ R +++Q+
Sbjct: 928 DPPVLAERNGRIISYTVVFRDINSQQ 953
Score = 50.1 bits (118), Expect = 2e-05
Identities = 130/685 (18%), Positives = 257/685 (37%), Gaps = 90/685 (13%)
Query: 884 YKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAF 943
Y + ++ G ++ +A + +P ++ ++ AT S+T+ W G + +Y +
Sbjct: 296 YTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTAT-SVTLTWDSGNSEPVTYYGIQY 354
Query: 944 RHS------QKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVS----GSLKNQINV-VGR 992
R + Q+VD ++ + L +Y + +V+ G + G
Sbjct: 355 RAAGTEGPFQEVDGVATTRY----SIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGE 410
Query: 993 TVPASVQGVIADNAYSSYSLIVSWQ---KAAGVAERYDILLLTE-----NGILLRNTSEP 1044
P+S + S+ +++V W+ + G+ Y + + N NT
Sbjct: 411 QAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAG 470
Query: 1045 ATTKQHKFEDLTPGKKYKIQILT---VSGGLFSKEAQTEGRT-VPAAVTDLRITENSTRH 1100
T L PG Y +++L V G S Q + + VPA D + S
Sbjct: 471 LLTT---VGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTR 527
Query: 1101 LSFRWTASEGE--LSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHS 1158
+ W E + + ++ D + Q + DP S++ ++L +Y+ + S
Sbjct: 528 IQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDP-TSSYTLEDLKPDTLYRFQLAARS 586
Query: 1159 --GELSNESFIFGRTVPASVSH-----LRGSNRNTTDSLWFNWSPASGDFD--------- 1202
G I RT ++ S + S +TT + +W P D
Sbjct: 587 DMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRV--SWVPPPADSRNGVITQYSV 644
Query: 1203 FYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHS----GDLSNKVTAES- 1257
YE + G + ++ + W GL +Y +WV H+ G S+ V +
Sbjct: 645 AYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTD 704
Query: 1258 RTAPS-PPSLMSFADIANTSLAITWKGPPDWTDYND---FELQWL------PRDALTVFN 1307
PS PP + + +T++ + WK P + +++ ++ PR L +
Sbjct: 705 EDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPR-GLPIIQ 763
Query: 1308 PYNNRKSEGRIVYGLRPGRSYQFNVK--TVSGDSWKTYSKPIF--GSVRTKPDKIQNLHC 1363
+++ + GL P +Y V T GD ++ K + G+V +P + +
Sbjct: 764 DVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMM--IST 821
Query: 1364 RPQNSTAIACSWIPPDS---DFDGYSIE-CRKMDTQE--VEFSRKLEKEKSLLNIMMLVP 1417
N+ + W PP + GY ++ CR + + ++F K+ + L
Sbjct: 822 TAMNTALL--QWHPPKELPGELLGYRLQYCRADEARPNTIDFG----KDDQHFTVTGLHK 875
Query: 1418 HKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSW 1477
Y+ + ++ E E T D P P ++ V ++ S+ +
Sbjct: 876 GTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTG----LTTSTTELAWDPPV 931
Query: 1478 FSDTNGAVKYFTVVVREADGSDELK 1502
++ NG + +TVV R+ + EL+
Sbjct: 932 LAERNGRIISYTVVFRDINSQQELQ 956
Score = 47.0 bits (110), Expect = 2e-04
Identities = 89/344 (25%), Positives = 136/344 (39%), Gaps = 54/344 (15%)
Query: 100 EERTVVLQTD---PLPPARFGVSKEKTTSTSLHVWW---TPSS--GKVTSYEVQLFDENN 151
E V+++TD P P R V E ST++HV+W PS G++ Y+V N
Sbjct: 695 ESSPVLVRTDEDVPSGPPR-KVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLEN 753
Query: 152 QKIQGVQIQES---TSWNEYTFFNLTAGSKYNIAITAVS----GGKRSFSVYTNGSTVPS 204
+ +G+ I + E T LT + Y++ + A + G + + T VP
Sbjct: 754 GEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPG 813
Query: 205 PVKDIGISTKANSLLISW---SHGSGNVERYRLMLM----DKGILVHGGVVDKHATSYAF 257
+ +T N+ L+ W G + YRL + + G D+H T
Sbjct: 814 RPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGL 873
Query: 258 HGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEV-----SNLKVTNDGSLTSLKVKWQR 312
H T Y++ L AGL K +RT P ++ NL VT + T+ ++ W
Sbjct: 874 HKGTT-YIFRLAAKNR-AGLGEEFEKEIRT-PEDLPSGFPQNLHVTGLTTSTT-ELAWDP 929
Query: 313 P-----PGNVDSYNITLSHKGTIKESRVLAPWITETHF--KELVPGRLYQVTV----SCV 361
P G + SY + I + L T+T F L P Y + V S
Sbjct: 930 PVLAERNGRIISYTVVFR---DINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKG 986
Query: 362 SGELSAQKMAVGRTFPDKVANLEANN----NGRMRSLVVSWSPP 401
SG LS + RT P V + A N S+++SW P
Sbjct: 987 SGPLSPSIQS--RTMP--VEQVFAKNFRVAAAMKTSVLLSWEVP 1026
Score = 44.3 bits (103), Expect = 0.001
Identities = 143/674 (21%), Positives = 249/674 (36%), Gaps = 85/674 (12%)
Query: 393 SLVVSWSPPA---GDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTG-LVPGRQYEVEV 448
+++V W PP G YR+ DS N ++ G L+PG Y + V
Sbjct: 429 TMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRV 488
Query: 449 IVES--GNLKNSERCQGRT---VPLAVLQLRVKHANETSLSIMWQTPVAE----WEKYII 499
+ + G+ S Q +T VP + + ++T + + W P E +E
Sbjct: 489 LAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYW 548
Query: 500 SLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSIS--GDLKNSSSVKGRTVP--- 554
+ D D HK +T DL P Y + + S G + +++ RT
Sbjct: 549 AAEDEDQQ--HKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTP 606
Query: 555 -AQVTDLHVANQGMTSSLFTNWTQAQGDVE---FYQVLLIHENVVIKN------ESISSE 604
A + + G T+ + +W D Q + +E V ++ + IS E
Sbjct: 607 SAPPQKVMCVSMGSTT-VRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE 665
Query: 605 TSRYSFHSLKSGSLYSVVV---TTVSGGISSRQVVVE-GRTVPSSVSGVTVNNSGRNDYL 660
S + L+ + Y V V T V G S V+V VPS + +
Sbjct: 666 HSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAV 725
Query: 661 SVSWLLAP-----GDVDNYEVTLSH--DGK-----VVQSLVIAKSVRECSFSSLTPGRLY 708
V W L G + Y+VT +G+ ++Q +++A++ +E + S LTP Y
Sbjct: 726 HVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEA-QETTISGLTPETTY 784
Query: 709 TVTITTRSGKYEN-HSFSQERTVPDKVQG---VSVSNSARSDYLRVSW---VHATGDFDH 761
+VT+ + K + S + T V G + +S +A + L + W G+
Sbjct: 785 SVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLG 843
Query: 762 YEVTIKNKNNF-IQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPE 820
Y + + T K + L G Y + K+ E PE
Sbjct: 844 YRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPE 903
Query: 821 PV-----KDLTLRNRSTEDLHVTW-----SGANGDVDQYEIQLLFNDMKVFPPFHLVNTA 870
+ ++L + +T + W + NG + Y + +F D+ + T
Sbjct: 904 DLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTV--VFRDINSQQELQNITTD 961
Query: 871 TEYRFTSLTPGRQY--KILVLTISGDVQQSAFIEGFTVPSA---VKNIHISPNGATDSLT 925
T + T L P Y K+ T G S I+ T+P KN ++ T S+
Sbjct: 962 TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKT-SVL 1020
Query: 926 VNWTPGGGDVDSY-TVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMI---ASVSG 981
++W DSY + F+ S + H L+ +Y ++ S +G
Sbjct: 1021 LSWEV----PDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAG 1076
Query: 982 SLKNQINVVGRTVP 995
L++ +++ RT P
Sbjct: 1077 GLQHLVSI--RTAP 1088
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 238 bits (607), Expect = 4e-62
Identities = 246/952 (25%), Positives = 401/952 (42%), Gaps = 112/952 (11%)
Query: 1071 GLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLY---NPDGNLQ 1127
G+ AQ +++P A +TEN+ ++ W + + Y + Y + DG Q
Sbjct: 309 GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQ 368
Query: 1128 ERAQVDPLVQSFSFQNLLQGRMYKMVI--VTHSGELSNESFIFGRT---VPASVSHLRGS 1182
+ + +S L Y++ + V G+ + RT PAS +
Sbjct: 369 IKEDIT--TTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQA 426
Query: 1183 NRNTTDSLWFNWSPA-------SGDFDFYELILYNPNGT-KKENWKDKDLTEWRFQGLVP 1234
+ ++ W G +Y + +P G +K N D LT L+
Sbjct: 427 RMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT--VGSLLE 484
Query: 1235 GRKYVLWVVTHS----GDLSNKVTAESRTA-PSPPSLMSFADIANTSLAITWKGPPDWTD 1289
Y + V+ + G LS+ + +++ P P + + TS+ ++W PP
Sbjct: 485 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS-PPRQES 543
Query: 1290 YNDFELQWLP----RDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSK 1345
+EL + R+ F+P + +V L+P Y F + S ++
Sbjct: 544 IIKYELLFREGDHGREVGRTFDP-----TTSYVVEDLKPNTEYAFRLAARSPQGLGAFT- 597
Query: 1346 PIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDS---------DFDGYSIECRKMDTQE 1396
P+ + +N + T++ SW PD+ ++G +++ T++
Sbjct: 598 PVVRQRTLQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKK 657
Query: 1397 VEFSRKLEKEKSLLNIMMLVPHKRY---LVSIKVQSAGMTSEVVEDSTITMIDRPPPPPP 1453
+ I L PH Y L + G+ V + +++ P P
Sbjct: 658 L--------------ITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP 703
Query: 1454 HIRVNEKDVLISKSSINFTVNCSWFSDTNGAV---KYFTVVV--READGSDELKPEQQHP 1508
+ D I + D V YF V+V R++ G L P P
Sbjct: 704 K---PDADGFIMV----------YLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGS-P 749
Query: 1509 LPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQK--- 1565
LE R+ + + S+ E P + A L P QK
Sbjct: 750 EDMDLEELIQDISRLQRRSLRHSRQLEVPRPY-------IAARFSVLPPTFHPGDQKQYG 802
Query: 1566 -FCDGPLKPHTAYRISIRAFTQLFDEDL--KEFTKPLYSDTFFSLPITTESEPLFGAIEG 1622
F + L+P Y + + A Q + F+ P D PI E L I
Sbjct: 803 GFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGP 862
Query: 1623 VSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDR----------PLSVHLNLG 1672
V A +F+I + V+A+L+ + K R+ R + P+ +
Sbjct: 863 VLAVVFIICI---VIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINF 919
Query: 1673 QKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNR 1732
Q + PI I H +L+A+ + LS+EYE + D G+ + + + L N+ KNR
Sbjct: 920 QTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESI-DPGQQFTWEHSNLEVNKPKNR 978
Query: 1733 YNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWE 1792
Y N++ YD +RV L ++ SDYINA+Y+ G + YI TQGPLP T DFW+MVWE
Sbjct: 979 YANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWE 1038
Query: 1793 QNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEE 1852
Q IVM+T+ EK R+KCD YWP ++ + YG + + +L L + +R F + +
Sbjct: 1039 QRSATIVMMTRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSL-HKN 1096
Query: 1853 QLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTG 1912
R +R F +T WPDHGVPE + F+R V+ P AGP VVHCSAGVGRTG
Sbjct: 1097 GSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC--NPPDAGPIVVHCSAGVGRTG 1154
Query: 1913 TFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL 1964
FI +D +L+++ + +VD+YG V +R R +MVQTE QY ++H+ + + +
Sbjct: 1155 CFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1206
Score = 195 bits (495), Expect = 4e-49
Identities = 103/243 (42%), Positives = 148/243 (60%), Gaps = 2/243 (0%)
Query: 1722 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1781
A LP N+ KNR NI+PY++TRV L + SDYINAS+I G ++ YI TQGPL
Sbjct: 1257 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1316
Query: 1782 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 1841
T +DFW+M+WE N +VM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1317 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1375
Query: 1842 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 1901
+REFK+ + + R +R F +T WP+ GVP++ + I F+ V + GP
Sbjct: 1376 ILREFKVT-DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1434
Query: 1902 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 1961
VHCSAGVGRTG FI L +L+++ + VDI+ V LR R MVQTE +Y + +Q
Sbjct: 1435 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL 1494
Query: 1962 DVL 1964
+ L
Sbjct: 1495 EYL 1497
Score = 43.1 bits (100), Expect = 0.003
Identities = 59/306 (19%), Positives = 117/306 (38%), Gaps = 31/306 (10%)
Query: 876 TSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDV 935
T + Y + ++ G ++ A I ++P A ++ N AT S+T+ W G D
Sbjct: 292 TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTAT-SITITWDSGNPDP 350
Query: 936 DSYTVSAFRHSQKVDSQTIPKHV--FEHTFHRLEAGEQYQIMIASVSG-----SLKNQIN 988
SY V ++ + I + + ++ L +Y+I +++V+ ++ +
Sbjct: 351 VSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVT 410
Query: 989 VVGRTVPASVQGVIADNAYSSYSLIVSWQKAA---GVAERYDILLLTENGILLRNTSEPA 1045
G PAS + S+ ++IV W++ G+ Y + E + N
Sbjct: 411 RTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGN----- 465
Query: 1046 TTKQHKFED--------LTPGKKYKIQIL---TVSGGLFSKEAQTEGRT-VPAAVTDLRI 1093
++H +D L + Y +++L +V G S Q + + VP +LR
Sbjct: 466 -WQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRA 524
Query: 1094 TENSTRHLSFRWTASEGE-LSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKM 1152
S ++ W+ E + Y + D + DP S+ ++L Y
Sbjct: 525 EARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDP-TTSYVVEDLKPNTEYAF 583
Query: 1153 VIVTHS 1158
+ S
Sbjct: 584 RLAARS 589
Score = 36.6 bits (83), Expect = 0.25
Identities = 63/267 (23%), Positives = 101/267 (37%), Gaps = 63/267 (23%)
Query: 266 YNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRP-PGNVDSYNITL 324
Y M+ ++ V++ P VT + + TS+ + W P V Y I
Sbjct: 300 YTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVT-ENTATSITITWDSGNPDPVSYYVIEY 358
Query: 325 SHKGT-----IKESRVLAPWITETHFK--ELVPGRLYQVTVSCVS--GELSAQKMAVGRT 375
K IKE IT T + L P Y++ VS V+ G+ + V RT
Sbjct: 359 KSKSQDGPYQIKED------ITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRT 412
Query: 376 FPDKVANLEANNNGRMRS---LVVSWSPPA---------------------GDWEQYRIL 411
A+ N RM S ++V W P G+W+++ +
Sbjct: 413 GEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV- 471
Query: 412 LFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVES--GNLKNSERCQGRT---V 466
+DS++ TVG L+ Y V V+ + G+ S+ Q +T V
Sbjct: 472 --DDSLLT---TVGS-----------LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGV 515
Query: 467 PLAVLQLRVKHANETSLSIMWQTPVAE 493
P + LR + +ETS+++ W P E
Sbjct: 516 PGQPMNLRAEARSETSITLSWSPPRQE 542
Score = 35.8 bits (81), Expect = 0.43
Identities = 65/310 (20%), Positives = 118/310 (38%), Gaps = 28/310 (9%)
Query: 778 IPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHV 837
+P N + Y+ + G EA Q +++P+ + + + +
Sbjct: 282 MPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITI 341
Query: 838 TWSGANGDVDQYEIQLLFNDMKVFPPFHLVN--TATEYRFTSLTPGRQYKILVLTIS--- 892
TW N D Y + + + P+ + T T Y L+P +Y+I V ++
Sbjct: 342 TWDSGNPDPVSYYV-IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIG 400
Query: 893 -GDVQQSAFIE-GFTVP-SAVKNIHISPNGATDSLTVNW----TPGG---GDVDSYTVSA 942
G +S G P SA +N+ AT ++ V W P G G YT+
Sbjct: 401 QGPPSESVVTRTGEQAPASAPRNVQARMLSAT-TMIVQWEEPVEPNGLIRGYRVYYTMEP 459
Query: 943 FRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVS----GSLKNQINV-VGRTVPAS 997
+ + T L E Y + + + + G L + I V + VP
Sbjct: 460 EHPVGNWQKHNVDDSLLT-TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ 518
Query: 998 VQGVIADNAYSSYSLIVSWQKAAGVA-ERYDILLLT-ENGILLRNTSEPATTKQHKFEDL 1055
+ A+ A S S+ +SW + +Y++L ++G + T +P T+ + EDL
Sbjct: 519 PMNLRAE-ARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTS--YVVEDL 575
Query: 1056 TPGKKYKIQI 1065
P +Y ++
Sbjct: 576 KPNTEYAFRL 585
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 238 bits (607), Expect = 4e-62
Identities = 246/952 (25%), Positives = 401/952 (42%), Gaps = 112/952 (11%)
Query: 1071 GLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLY---NPDGNLQ 1127
G+ AQ +++P A +TEN+ ++ W + + Y + Y + DG Q
Sbjct: 305 GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQ 364
Query: 1128 ERAQVDPLVQSFSFQNLLQGRMYKMVI--VTHSGELSNESFIFGRT---VPASVSHLRGS 1182
+ + +S L Y++ + V G+ + RT PAS +
Sbjct: 365 IKEDIT--TTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQA 422
Query: 1183 NRNTTDSLWFNWSPA-------SGDFDFYELILYNPNGT-KKENWKDKDLTEWRFQGLVP 1234
+ ++ W G +Y + +P G +K N D LT L+
Sbjct: 423 RMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT--VGSLLE 480
Query: 1235 GRKYVLWVVTHS----GDLSNKVTAESRTA-PSPPSLMSFADIANTSLAITWKGPPDWTD 1289
Y + V+ + G LS+ + +++ P P + + TS+ ++W PP
Sbjct: 481 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS-PPRQES 539
Query: 1290 YNDFELQWLP----RDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSK 1345
+EL + R+ F+P + +V L+P Y F + S ++
Sbjct: 540 IIKYELLFREGDHGREVGRTFDP-----TTSYVVEDLKPNTEYAFRLAARSPQGLGAFT- 593
Query: 1346 PIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDS---------DFDGYSIECRKMDTQE 1396
P+ + +N + T++ SW PD+ ++G +++ T++
Sbjct: 594 PVVRQRTLQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKK 653
Query: 1397 VEFSRKLEKEKSLLNIMMLVPHKRY---LVSIKVQSAGMTSEVVEDSTITMIDRPPPPPP 1453
+ I L PH Y L + G+ V + +++ P P
Sbjct: 654 L--------------ITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP 699
Query: 1454 HIRVNEKDVLISKSSINFTVNCSWFSDTNGAV---KYFTVVV--READGSDELKPEQQHP 1508
+ D I + D V YF V+V R++ G L P P
Sbjct: 700 K---PDADGFIMV----------YLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGS-P 745
Query: 1509 LPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQK--- 1565
LE R+ + + S+ E P + A L P QK
Sbjct: 746 EDMDLEELIQDISRLQRRSLRHSRQLEVPRPY-------IAARFSVLPPTFHPGDQKQYG 798
Query: 1566 -FCDGPLKPHTAYRISIRAFTQLFDEDL--KEFTKPLYSDTFFSLPITTESEPLFGAIEG 1622
F + L+P Y + + A Q + F+ P D PI E L I
Sbjct: 799 GFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGP 858
Query: 1623 VSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDR----------PLSVHLNLG 1672
V A +F+I + V+A+L+ + K R+ R + P+ +
Sbjct: 859 VLAVVFIICI---VIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINF 915
Query: 1673 QKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNR 1732
Q + PI I H +L+A+ + LS+EYE + D G+ + + + L N+ KNR
Sbjct: 916 QTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESI-DPGQQFTWEHSNLEVNKPKNR 974
Query: 1733 YNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWE 1792
Y N++ YD +RV L ++ SDYINA+Y+ G + YI TQGPLP T DFW+MVWE
Sbjct: 975 YANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWE 1034
Query: 1793 QNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEE 1852
Q IVM+T+ EK R+KCD YWP ++ + YG + + +L L + +R F + +
Sbjct: 1035 QRSATIVMMTRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSL-HKN 1092
Query: 1853 QLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTG 1912
R +R F +T WPDHGVPE + F+R V+ P AGP VVHCSAGVGRTG
Sbjct: 1093 GSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTC--NPPDAGPIVVHCSAGVGRTG 1150
Query: 1913 TFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL 1964
FI +D +L+++ + +VD+YG V +R R +MVQTE QY ++H+ + + +
Sbjct: 1151 CFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1202
Score = 195 bits (495), Expect = 4e-49
Identities = 103/243 (42%), Positives = 148/243 (60%), Gaps = 2/243 (0%)
Query: 1722 ALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPG 1781
A LP N+ KNR NI+PY++TRV L + SDYINAS+I G ++ YI TQGPL
Sbjct: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312
Query: 1782 TKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEW 1841
T +DFW+M+WE N +VM+T+ E GR KC YWPA++ S Y ++ ++E +P++
Sbjct: 1313 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAER-SARYQYFVVDPMAEYNMPQY 1371
Query: 1842 TIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTV 1901
+REFK+ + + R +R F +T WP+ GVP++ + I F+ V + GP
Sbjct: 1372 ILREFKVT-DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1430
Query: 1902 VHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 1961
VHCSAGVGRTG FI L +L+++ + VDI+ V LR R MVQTE +Y + +Q
Sbjct: 1431 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL 1490
Query: 1962 DVL 1964
+ L
Sbjct: 1491 EYL 1493
Score = 43.1 bits (100), Expect = 0.003
Identities = 59/306 (19%), Positives = 117/306 (38%), Gaps = 31/306 (10%)
Query: 876 TSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDV 935
T + Y + ++ G ++ A I ++P A ++ N AT S+T+ W G D
Sbjct: 288 TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTAT-SITITWDSGNPDP 346
Query: 936 DSYTVSAFRHSQKVDSQTIPKHV--FEHTFHRLEAGEQYQIMIASVSG-----SLKNQIN 988
SY V ++ + I + + ++ L +Y+I +++V+ ++ +
Sbjct: 347 VSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVT 406
Query: 989 VVGRTVPASVQGVIADNAYSSYSLIVSWQKAA---GVAERYDILLLTENGILLRNTSEPA 1045
G PAS + S+ ++IV W++ G+ Y + E + N
Sbjct: 407 RTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGN----- 461
Query: 1046 TTKQHKFED--------LTPGKKYKIQIL---TVSGGLFSKEAQTEGRT-VPAAVTDLRI 1093
++H +D L + Y +++L +V G S Q + + VP +LR
Sbjct: 462 -WQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRA 520
Query: 1094 TENSTRHLSFRWTASEGE-LSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKM 1152
S ++ W+ E + Y + D + DP S+ ++L Y
Sbjct: 521 EARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDP-TTSYVVEDLKPNTEYAF 579
Query: 1153 VIVTHS 1158
+ S
Sbjct: 580 RLAARS 585
Score = 36.6 bits (83), Expect = 0.25
Identities = 63/267 (23%), Positives = 101/267 (37%), Gaps = 63/267 (23%)
Query: 266 YNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTNDGSLTSLKVKWQRP-PGNVDSYNITL 324
Y M+ ++ V++ P VT + + TS+ + W P V Y I
Sbjct: 296 YTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVT-ENTATSITITWDSGNPDPVSYYVIEY 354
Query: 325 SHKGT-----IKESRVLAPWITETHFK--ELVPGRLYQVTVSCVS--GELSAQKMAVGRT 375
K IKE IT T + L P Y++ VS V+ G+ + V RT
Sbjct: 355 KSKSQDGPYQIKED------ITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRT 408
Query: 376 FPDKVANLEANNNGRMRS---LVVSWSPPA---------------------GDWEQYRIL 411
A+ N RM S ++V W P G+W+++ +
Sbjct: 409 GEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV- 467
Query: 412 LFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVES--GNLKNSERCQGRT---V 466
+DS++ TVG L+ Y V V+ + G+ S+ Q +T V
Sbjct: 468 --DDSLLT---TVGS-----------LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGV 511
Query: 467 PLAVLQLRVKHANETSLSIMWQTPVAE 493
P + LR + +ETS+++ W P E
Sbjct: 512 PGQPMNLRAEARSETSITLSWSPPRQE 538
Score = 35.8 bits (81), Expect = 0.43
Identities = 65/310 (20%), Positives = 118/310 (38%), Gaps = 28/310 (9%)
Query: 778 IPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHV 837
+P N + Y+ + G EA Q +++P+ + + + +
Sbjct: 278 MPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITI 337
Query: 838 TWSGANGDVDQYEIQLLFNDMKVFPPFHLVN--TATEYRFTSLTPGRQYKILVLTIS--- 892
TW N D Y + + + P+ + T T Y L+P +Y+I V ++
Sbjct: 338 TWDSGNPDPVSYYV-IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIG 396
Query: 893 -GDVQQSAFIE-GFTVP-SAVKNIHISPNGATDSLTVNW----TPGG---GDVDSYTVSA 942
G +S G P SA +N+ AT ++ V W P G G YT+
Sbjct: 397 QGPPSESVVTRTGEQAPASAPRNVQARMLSAT-TMIVQWEEPVEPNGLIRGYRVYYTMEP 455
Query: 943 FRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVS----GSLKNQINV-VGRTVPAS 997
+ + T L E Y + + + + G L + I V + VP
Sbjct: 456 EHPVGNWQKHNVDDSLLT-TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ 514
Query: 998 VQGVIADNAYSSYSLIVSWQKAAGVA-ERYDILLLT-ENGILLRNTSEPATTKQHKFEDL 1055
+ A+ A S S+ +SW + +Y++L ++G + T +P T+ + EDL
Sbjct: 515 PMNLRAE-ARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTS--YVVEDL 571
Query: 1056 TPGKKYKIQI 1065
P +Y ++
Sbjct: 572 KPNTEYAFRL 581
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 238 bits (607), Expect = 4e-62
Identities = 149/454 (32%), Positives = 223/454 (49%), Gaps = 61/454 (13%)
Query: 1562 TQQKFCDGPLKPHTAYRISIRAFTQLFDED----LKEFTKPLYSDTFFSLPITTESEPLF 1617
T Q F + PL P Y I +A + + E ++ TK ++ +P +
Sbjct: 692 TYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRV 751
Query: 1618 GAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARL-------------------S 1658
I G+SAG+ + +L+ VV L++ + K++ R+ +
Sbjct: 752 VKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQST 811
Query: 1659 IRRDRPLSVHL-------------NLGQKGNRKTSCP-------------------IKIN 1686
+ + PLS+ + + +R P I++
Sbjct: 812 LHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVA 871
Query: 1687 QFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKL 1746
H ++ +Y +EYE + G++ S D+A +NR KNRY NI+ YD +RV L
Sbjct: 872 DLLQHINLMKTSDSYGFKEEYESFFE-GQSASWDVAKKDQNRAKNRYGNIIAYDHSRVIL 930
Query: 1747 SNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVE 1806
V+DDP SDYINA+YI G YI TQGP+ T DFW+M+W++ IVMVT VE
Sbjct: 931 QPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVE 990
Query: 1807 KGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYT 1866
GRVKC YWP D + YGD + + L E+ +R F + + R ++ FH+T
Sbjct: 991 VGRVKCYKYWPDDTE--VYGDFKVTCVEMEPLAEYVVRTFTL-ERRGYNEIREVKQFHFT 1047
Query: 1867 VWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDS 1926
WPDHGVP L+ F+R V+ ++ P AGP VVHCSAG GRTG +I +D +L +
Sbjct: 1048 GWPDHGVPYHATGLLSFIRRVK--LSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAER 1105
Query: 1927 KDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 1960
+ VDIY V LR R++MVQTE QY+++H +
Sbjct: 1106 EGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAI 1139
Score = 132 bits (331), Expect = 4e-30
Identities = 87/293 (29%), Positives = 153/293 (52%), Gaps = 13/293 (4%)
Query: 1681 CPIKINQFEGHFMKLQADSNYLLSKEYEELKDVG---RNQSCDIALLPENRGKNRYNNIL 1737
C K F+ + Q +S++L E++ L V + + C IA LP N KNR+ ++L
Sbjct: 1153 CEFKAAYFDMIRIDSQTNSSHL-KDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDML 1211
Query: 1738 PYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN 1797
P D L +D + S+YINA+ + +IVTQ PLP T DFW++V++ +
Sbjct: 1212 PPDRCLPFLITIDGES-SNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTS 1270
Query: 1798 IVMVTQC-VEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICG-EEQLD 1855
IVM+ + + +G C YWP ++ L YG + ++ +S S+ + R F+IC +
Sbjct: 1271 IVMLNEVDLSQG---CPQYWP-EEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQE 1326
Query: 1856 AHRLIRHFHYTVWPDHG-VPETTQSLIQFVRTVRDYINR-SPGAGPTVVHCSAGVGRTGT 1913
+ +++ F Y W H VP + +S ++ + V + G G T++HC G GR+G
Sbjct: 1327 GYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGM 1386
Query: 1914 FIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRA 1966
F A+ +++ + ++ VD++ AV LR + +MV+ QY + + + L +
Sbjct: 1387 FCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 235 bits (600), Expect = 3e-61
Identities = 125/280 (44%), Positives = 167/280 (59%), Gaps = 10/280 (3%)
Query: 1683 IKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDAT 1742
I++ H +++ Y +EYE + G++ D A ENR KNRY NI+ YD +
Sbjct: 880 IRVADLLQHITQMKCAEGYGFKEEYESFFE-GQSAPWDSAKKDENRMKNRYGNIIAYDHS 938
Query: 1743 RVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVT 1802
RV+L ++ D SDYIN +YI G + YI TQGP+ T DFW+MVW +N +I+MVT
Sbjct: 939 RVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT 998
Query: 1803 QCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH--RLI 1860
VE GRVKC YWP D + Y D+ + ++ +L E+ IR F + E+ H R I
Sbjct: 999 NLVEVGRVKCCKYWPDDTE--IYKDIKVTLIETELLAEYVIRTFAV---EKRGVHEIREI 1053
Query: 1861 RHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRI 1920
R FH+T WPDHGVP L+ FVR V+ P AGP VVHCSAG GRTG FI +D +
Sbjct: 1054 RQFHFTGWPDHGVPYHATGLLGFVRQVKS--KSPPSAGPLVVHCSAGAGRTGCFIVIDIM 1111
Query: 1921 LQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 1960
L + + VDIY V +LR RV+MVQTE QYV++H +
Sbjct: 1112 LDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAI 1151
Score = 127 bits (318), Expect = 1e-28
Identities = 81/255 (31%), Positives = 138/255 (54%), Gaps = 7/255 (2%)
Query: 1715 RNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIV 1774
R + C IALLP N KNR +ILP D L +D + S+YINA+ + +IV
Sbjct: 1201 RVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAALMDSYKQPSAFIV 1259
Query: 1775 TQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLS 1834
TQ PLP T DFW++V + + ++VM+ V+ ++ C YWP + +G + ++ +S
Sbjct: 1260 TQHPLPNTVKDFWRLVLDYHCTSVVMLND-VDPAQL-CPQYWP-ENGVHRHGPIQVEFVS 1316
Query: 1835 ESVLPEWTIREFKICGEEQ-LDAHRLIRHFHYTVWPDH-GVPETTQSLIQFVRTVRDYIN 1892
+ + R F+I + D +R+++ F + WP + P + +S ++ +R V +
Sbjct: 1317 ADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQE 1376
Query: 1893 R-SPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTEC 1951
+ G G TVVHC G GR+GTF A+ + + L + +VD++ AV LR ++ +MV
Sbjct: 1377 EYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLD 1436
Query: 1952 QYVYLHQCVRDVLRA 1966
QY + ++ + L +
Sbjct: 1437 QYKFCYEVALEYLNS 1451
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 235 bits (600), Expect = 3e-61
Identities = 125/280 (44%), Positives = 167/280 (59%), Gaps = 10/280 (3%)
Query: 1683 IKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDAT 1742
I++ H +++ Y +EYE + G++ D A ENR KNRY NI+ YD +
Sbjct: 893 IRVADLLQHITQMKCAEGYGFKEEYESFFE-GQSAPWDSAKKDENRMKNRYGNIIAYDHS 951
Query: 1743 RVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVT 1802
RV+L ++ D SDYIN +YI G + YI TQGP+ T DFW+MVW +N +I+MVT
Sbjct: 952 RVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT 1011
Query: 1803 QCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH--RLI 1860
VE GRVKC YWP D + Y D+ + ++ +L E+ IR F + E+ H R I
Sbjct: 1012 NLVEVGRVKCCKYWPDDTE--IYKDIKVTLIETELLAEYVIRTFAV---EKRGVHEIREI 1066
Query: 1861 RHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRI 1920
R FH+T WPDHGVP L+ FVR V+ P AGP VVHCSAG GRTG FI +D +
Sbjct: 1067 RQFHFTGWPDHGVPYHATGLLGFVRQVKS--KSPPSAGPLVVHCSAGAGRTGCFIVIDIM 1124
Query: 1921 LQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 1960
L + + VDIY V +LR RV+MVQTE QYV++H +
Sbjct: 1125 LDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAI 1164
Score = 127 bits (318), Expect = 1e-28
Identities = 81/255 (31%), Positives = 138/255 (54%), Gaps = 7/255 (2%)
Query: 1715 RNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIV 1774
R + C IALLP N KNR +ILP D L +D + S+YINA+ + +IV
Sbjct: 1214 RVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAALMDSYKQPSAFIV 1272
Query: 1775 TQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLS 1834
TQ PLP T DFW++V + + ++VM+ V+ ++ C YWP + +G + ++ +S
Sbjct: 1273 TQHPLPNTVKDFWRLVLDYHCTSVVMLND-VDPAQL-CPQYWP-ENGVHRHGPIQVEFVS 1329
Query: 1835 ESVLPEWTIREFKICGEEQ-LDAHRLIRHFHYTVWPDH-GVPETTQSLIQFVRTVRDYIN 1892
+ + R F+I + D +R+++ F + WP + P + +S ++ +R V +
Sbjct: 1330 ADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQE 1389
Query: 1893 R-SPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTEC 1951
+ G G TVVHC G GR+GTF A+ + + L + +VD++ AV LR ++ +MV
Sbjct: 1390 EYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLD 1449
Query: 1952 QYVYLHQCVRDVLRA 1966
QY + ++ + L +
Sbjct: 1450 QYKFCYEVALEYLNS 1464
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 233 bits (595), Expect = 1e-60
Identities = 133/356 (37%), Positives = 199/356 (55%), Gaps = 10/356 (2%)
Query: 1611 TESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDR---PLSV 1667
++ P+ + +S+ L +I ++ V+ +L ++ G S RLS R P SV
Sbjct: 138 SDETPIIAVMVALSS-LLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSV 196
Query: 1668 HLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPEN 1727
L + P+ +++ E + AD N L +E+ L +C+ A EN
Sbjct: 197 PLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEEN 256
Query: 1728 RGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFW 1787
+ KNRY NILPYD +RV L+ V+ P SDYINAS+I G + ++I QGP T +DFW
Sbjct: 257 KEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFW 316
Query: 1788 KMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREF- 1846
+M+WEQN IVMVT E+ KC YWP DQ YG++ + + +VL ++T+R+F
Sbjct: 317 RMIWEQNTATIVMVTNLKERKECKCAQYWP-DQGCWTYGNIRVSVEDVTVLVDYTVRKFC 375
Query: 1847 --KICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHC 1904
++ RLI FH+T WPD GVP T +++F++ V+ AG VVHC
Sbjct: 376 IQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVK--ACNPQYAGAIVVHC 433
Query: 1905 SAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 1960
SAGVGRTGTF+ +D +L + ++ VD+YG V +R R MVQT+ QYV+++Q +
Sbjct: 434 SAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQAL 489
Score = 190 bits (483), Expect = 1e-47
Identities = 102/289 (35%), Positives = 165/289 (57%), Gaps = 8/289 (2%)
Query: 1683 IKINQFEGH----FMKLQADSNYLLSKEYEELKDVG-RNQSCDIALLPENRGKNRYNNIL 1737
+++ E H + K+ SN L +E+++L + +N LP N KNR I+
Sbjct: 500 LEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQII 559
Query: 1738 PYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN 1797
PY+ RV + + +DY+NAS+I G + YI +QGPL T +DFW+M+WE +
Sbjct: 560 PYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCS 619
Query: 1798 IVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH 1857
IVM+T+ E+G+ KC YWP+D + YGD+ +++ E +T+R+ + + +
Sbjct: 620 IVMLTELEERGQEKCAQYWPSD-GLVSYGDITVELKKEEECESYTVRDLLVTNTRE-NKS 677
Query: 1858 RLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIAL 1917
R IR FH+ WP+ G+P + +I + V+ +S G P VHCSAG GRTGTF AL
Sbjct: 678 RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQS-GNHPITVHCSAGAGRTGTFCAL 736
Query: 1918 DRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRA 1966
+L+++ ++ +D++ V LRL R HMVQT QY + ++ V++ + A
Sbjct: 737 STVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA 785
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 233 bits (595), Expect = 1e-60
Identities = 133/356 (37%), Positives = 199/356 (55%), Gaps = 10/356 (2%)
Query: 1611 TESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDR---PLSV 1667
++ P+ + +S+ L +I ++ V+ +L ++ G S RLS R P SV
Sbjct: 138 SDETPIIAVMVALSS-LLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSV 196
Query: 1668 HLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPEN 1727
L + P+ +++ E + AD N L +E+ L +C+ A EN
Sbjct: 197 PLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEEN 256
Query: 1728 RGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFW 1787
+ KNRY NILPYD +RV L+ V+ P SDYINAS+I G + ++I QGP T +DFW
Sbjct: 257 KEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFW 316
Query: 1788 KMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREF- 1846
+M+WEQN IVMVT E+ KC YWP DQ YG++ + + +VL ++T+R+F
Sbjct: 317 RMIWEQNTATIVMVTNLKERKECKCAQYWP-DQGCWTYGNIRVSVEDVTVLVDYTVRKFC 375
Query: 1847 --KICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHC 1904
++ RLI FH+T WPD GVP T +++F++ V+ AG VVHC
Sbjct: 376 IQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVK--ACNPQYAGAIVVHC 433
Query: 1905 SAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 1960
SAGVGRTGTF+ +D +L + ++ VD+YG V +R R MVQT+ QYV+++Q +
Sbjct: 434 SAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQAL 489
Score = 190 bits (483), Expect = 1e-47
Identities = 102/289 (35%), Positives = 165/289 (57%), Gaps = 8/289 (2%)
Query: 1683 IKINQFEGH----FMKLQADSNYLLSKEYEELKDVG-RNQSCDIALLPENRGKNRYNNIL 1737
+++ E H + K+ SN L +E+++L + +N LP N KNR I+
Sbjct: 500 LEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQII 559
Query: 1738 PYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN 1797
PY+ RV + + +DY+NAS+I G + YI +QGPL T +DFW+M+WE +
Sbjct: 560 PYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCS 619
Query: 1798 IVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH 1857
IVM+T+ E+G+ KC YWP+D + YGD+ +++ E +T+R+ + + +
Sbjct: 620 IVMLTELEERGQEKCAQYWPSD-GLVSYGDITVELKKEEECESYTVRDLLVTNTRE-NKS 677
Query: 1858 RLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIAL 1917
R IR FH+ WP+ G+P + +I + V+ +S G P VHCSAG GRTGTF AL
Sbjct: 678 RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQS-GNHPITVHCSAGAGRTGTFCAL 736
Query: 1918 DRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRA 1966
+L+++ ++ +D++ V LRL R HMVQT QY + ++ V++ + A
Sbjct: 737 STVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA 785
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 233 bits (594), Expect = 1e-60
Identities = 133/355 (37%), Positives = 198/355 (55%), Gaps = 10/355 (2%)
Query: 1612 ESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDR---PLSVH 1668
+ P+ + +S+ L +I ++ V+ +L ++ G S RLS R P SV
Sbjct: 148 DETPIIAVMVALSS-LLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVP 206
Query: 1669 LNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENR 1728
L + P+ +++ E + AD N L +E+ L +C+ A EN+
Sbjct: 207 LLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENK 266
Query: 1729 GKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWK 1788
KNRY NILPYD +RV L+ V+ P SDYINAS+I G + ++I QGP T +DFW+
Sbjct: 267 EKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWR 326
Query: 1789 MVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREF-- 1846
M+WEQN IVMVT E+ KC YWP DQ YG++ + + +VL ++T+R+F
Sbjct: 327 MIWEQNTATIVMVTNLKERKECKCAQYWP-DQGCWTYGNIRVSVEDVTVLVDYTVRKFCI 385
Query: 1847 -KICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCS 1905
++ RLI FH+T WPD GVP T +++F++ V+ AG VVHCS
Sbjct: 386 QQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVK--ACNPQYAGAIVVHCS 443
Query: 1906 AGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCV 1960
AGVGRTGTF+ +D +L + ++ VD+YG V +R R MVQT+ QYV+++Q +
Sbjct: 444 AGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQAL 498
Score = 190 bits (483), Expect = 1e-47
Identities = 102/289 (35%), Positives = 165/289 (57%), Gaps = 8/289 (2%)
Query: 1683 IKINQFEGH----FMKLQADSNYLLSKEYEELKDVG-RNQSCDIALLPENRGKNRYNNIL 1737
+++ E H + K+ SN L +E+++L + +N LP N KNR I+
Sbjct: 509 LEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQII 568
Query: 1738 PYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN 1797
PY+ RV + + +DY+NAS+I G + YI +QGPL T +DFW+M+WE +
Sbjct: 569 PYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCS 628
Query: 1798 IVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAH 1857
IVM+T+ E+G+ KC YWP+D + YGD+ +++ E +T+R+ + + +
Sbjct: 629 IVMLTELEERGQEKCAQYWPSD-GLVSYGDITVELKKEEECESYTVRDLLVTNTRE-NKS 686
Query: 1858 RLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIAL 1917
R IR FH+ WP+ G+P + +I + V+ +S G P VHCSAG GRTGTF AL
Sbjct: 687 RQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQS-GNHPITVHCSAGAGRTGTFCAL 745
Query: 1918 DRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRA 1966
+L+++ ++ +D++ V LRL R HMVQT QY + ++ V++ + A
Sbjct: 746 STVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA 794
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 233 bits (593), Expect = 2e-60
Identities = 130/304 (42%), Positives = 184/304 (60%), Gaps = 23/304 (7%)
Query: 1683 IKINQFEGHFMKLQADSNYLLSKEYEELKDVGRN-QSCDIAL--------LPENRGKNRY 1733
I I F H L A S + ++E+E LK+ + QSC + L P+N+ KNRY
Sbjct: 1699 IPIKHFPKHVADLHASSGF--TEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRY 1756
Query: 1734 NNILPYDATRVKLSNV--DDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVW 1791
NI+ YD +RVKL+ + D +DYINA+Y+ G N + YI QGPL T +DFW+M+W
Sbjct: 1757 INIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIW 1816
Query: 1792 EQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREF----- 1846
E NV IVM+T VEKGR KCD YWPAD S YG+ ++ S VL +T+R F
Sbjct: 1817 EHNVEVIVMITNLVEKGRRKCDQYWPAD-GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNT 1875
Query: 1847 --KICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHC 1904
K ++ + R++ +HYT WPD GVPE + ++ FVR Y R GP VVHC
Sbjct: 1876 KIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAA-YAKRH-AVGPVVVHC 1933
Query: 1905 SAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL 1964
SAGVGRTGT+I LD +LQQ+ + +V+I+G + +R R ++VQTE QYV++H + + +
Sbjct: 1934 SAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI 1993
Query: 1965 RARK 1968
+++
Sbjct: 1994 LSKE 1997
Score = 115 bits (288), Expect = 4e-25
Identities = 87/281 (30%), Positives = 140/281 (49%), Gaps = 19/281 (6%)
Query: 1703 LSKEYEELKDVGRNQSCDIALLPE-NRGKNRYNNILPYDATRVKLSNVDDDPCSDYINAS 1761
L K+++ L QS A L + NR KNR ++I+P + +RV +S++ + +DYINAS
Sbjct: 2023 LEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEG-TDYINAS 2081
Query: 1762 YIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQD 1821
YI G E+I+TQ PL T DFW+M+W+ N +VM+ + YWP +
Sbjct: 2082 YIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKDE 2140
Query: 1822 SLYYGDLILQMLSE-----SVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVP-E 1875
+ + +++E S + I++F I Q D +RHF WP+ P
Sbjct: 2141 PINCESFKVTLMAEEHKCLSNEEKLIIQDF-ILEATQDDYVLEVRHFQCPKWPNPDSPIS 2199
Query: 1876 TTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGA 1935
T LI ++ + NR GP +VH G GTF AL ++ QL+ ++SVD+Y
Sbjct: 2200 KTFELISVIK--EEAANRD---GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQV 2254
Query: 1936 VHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENP 1976
+ L R + QY +L++ + ++ R ++ENP
Sbjct: 2255 AKMINLMRPGVFADIEQYQFLYKVILSLVSTR----QEENP 2291
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,254,509
Number of Sequences: 37866
Number of extensions: 3544250
Number of successful extensions: 13420
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 132
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 9967
Number of HSP's gapped (non-prelim): 1601
length of query: 1997
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1880
effective length of database: 13,817,196
effective search space: 25976328480
effective search space used: 25976328480
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.