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Search of human proteins with 157671917
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157671917 hypothetical protein LOC374864 isoform 2 [Homo
sapiens]
(829 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157671917 hypothetical protein LOC374864 isoform 2 [Homo sapi... 1635 0.0
gi|157671919 hypothetical protein LOC374864 isoform 1 [Homo sapi... 1616 0.0
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 91 6e-18
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 86 1e-16
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 86 2e-16
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 86 2e-16
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 85 2e-16
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 85 3e-16
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 85 3e-16
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho... 84 5e-16
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 84 7e-16
gi|118498362 kinectin 1 isoform b [Homo sapiens] 83 9e-16
gi|71061468 centromere protein E [Homo sapiens] 83 9e-16
gi|38044112 restin isoform b [Homo sapiens] 82 3e-15
gi|4506751 restin isoform a [Homo sapiens] 82 3e-15
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 81 3e-15
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 81 3e-15
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 81 3e-15
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 81 5e-15
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 80 6e-15
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 80 6e-15
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 80 8e-15
gi|21735548 centrosomal protein 2 [Homo sapiens] 80 8e-15
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 80 8e-15
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 80 8e-15
gi|118498368 kinectin 1 isoform c [Homo sapiens] 79 1e-14
gi|156104908 myosin heavy chain 6 [Homo sapiens] 79 1e-14
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 79 2e-14
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 79 2e-14
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 79 2e-14
>gi|157671917 hypothetical protein LOC374864 isoform 2 [Homo
sapiens]
Length = 829
Score = 1635 bits (4233), Expect = 0.0
Identities = 829/829 (100%), Positives = 829/829 (100%)
Query: 1 MTENKTVSSSSTRDDQTNIGLTCQEVKALREKAWSRTNEGNAMSQSLVLYGASKENSEGF 60
MTENKTVSSSSTRDDQTNIGLTCQEVKALREKAWSRTNEGNAMSQSLVLYGASKENSEGF
Sbjct: 1 MTENKTVSSSSTRDDQTNIGLTCQEVKALREKAWSRTNEGNAMSQSLVLYGASKENSEGF 60
Query: 61 HESKMTNTEGVNKGIYFSYPCRRHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETS 120
HESKMTNTEGVNKGIYFSYPCRRHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETS
Sbjct: 61 HESKMTNTEGVNKGIYFSYPCRRHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETS 120
Query: 121 FEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETD 180
FEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETD
Sbjct: 121 FEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETD 180
Query: 181 RADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKAN 240
RADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKAN
Sbjct: 181 RADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKAN 240
Query: 241 QLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRK 300
QLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRK
Sbjct: 241 QLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRK 300
Query: 301 VNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVIN 360
VNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVIN
Sbjct: 301 VNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVIN 360
Query: 361 VNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVND 420
VNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVND
Sbjct: 361 VNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVND 420
Query: 421 FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESE 480
FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESE
Sbjct: 421 FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESE 480
Query: 481 IKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKL 540
IKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKL
Sbjct: 481 IKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKL 540
Query: 541 TQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSL 600
TQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSL
Sbjct: 541 TQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSL 600
Query: 601 DKEHSVSKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFIT 660
DKEHSVSKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFIT
Sbjct: 601 DKEHSVSKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFIT 660
Query: 661 MRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLR 720
MRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLR
Sbjct: 661 MRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLR 720
Query: 721 LAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLF 780
LAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLF
Sbjct: 721 LAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLF 780
Query: 781 SQMRLANFQTDSQESIQKILAVQEESSNLMQHILGFFQTLTDGTCENDG 829
SQMRLANFQTDSQESIQKILAVQEESSNLMQHILGFFQTLTDGTCENDG
Sbjct: 781 SQMRLANFQTDSQESIQKILAVQEESSNLMQHILGFFQTLTDGTCENDG 829
>gi|157671919 hypothetical protein LOC374864 isoform 1 [Homo
sapiens]
Length = 867
Score = 1616 bits (4184), Expect = 0.0
Identities = 829/867 (95%), Positives = 829/867 (95%), Gaps = 38/867 (4%)
Query: 1 MTENKTVSSSSTRDDQTNIGLTCQEVKALREKAWSRTNEGNAMSQSLVLYGASKENSEGF 60
MTENKTVSSSSTRDDQTNIGLTCQEVKALREKAWSRTNEGNAMSQSLVLYGASKENSEGF
Sbjct: 1 MTENKTVSSSSTRDDQTNIGLTCQEVKALREKAWSRTNEGNAMSQSLVLYGASKENSEGF 60
Query: 61 HESKMTNTEGVNKGIYFSYPCRRHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETS 120
HESKMTNTEGVNKGIYFSYPCRRHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETS
Sbjct: 61 HESKMTNTEGVNKGIYFSYPCRRHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETS 120
Query: 121 FEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETD 180
FEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETD
Sbjct: 121 FEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETD 180
Query: 181 RADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKAN 240
RADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKAN
Sbjct: 181 RADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKAN 240
Query: 241 QLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRK 300
QLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRK
Sbjct: 241 QLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRK 300
Query: 301 VNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVIN 360
VNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVIN
Sbjct: 301 VNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVIN 360
Query: 361 VNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVND 420
VNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVND
Sbjct: 361 VNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVND 420
Query: 421 FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESE 480
FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESE
Sbjct: 421 FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESE 480
Query: 481 IKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKL 540
IKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKL
Sbjct: 481 IKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKL 540
Query: 541 TQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSL 600
TQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSL
Sbjct: 541 TQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSL 600
Query: 601 DKEHSV--------------------------------------SKRSAIFKDLEATKSK 622
DKEHSV SKRSAIFKDLEATKSK
Sbjct: 601 DKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSK 660
Query: 623 TMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDC 682
TMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDC
Sbjct: 661 TMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDC 720
Query: 683 EERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNI 742
EERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNI
Sbjct: 721 EERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNI 780
Query: 743 YDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAV 802
YDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAV
Sbjct: 781 YDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAV 840
Query: 803 QEESSNLMQHILGFFQTLTDGTCENDG 829
QEESSNLMQHILGFFQTLTDGTCENDG
Sbjct: 841 QEESSNLMQHILGFFQTLTDGTCENDG 867
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 90.5 bits (223), Expect = 6e-18
Identities = 146/715 (20%), Positives = 296/715 (41%), Gaps = 115/715 (16%)
Query: 125 SRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCP-ELKQEMETLLSEAIRLIKSLETD--- 180
+RTSS D S+ + +++ + + E++Q+ T + +++K L+ +
Sbjct: 414 NRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQ 473
Query: 181 RADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKAN 240
R + E + Q K ++ +I+ + QE E+E + +
Sbjct: 474 RRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENE------------VSTLKD 521
Query: 241 QLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRK 300
QL+ +K + AN K+ + E LL ++ + ++ K+H + + L
Sbjct: 522 QLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLE-S 580
Query: 301 VNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKRE-------IYQLNSLFDH 353
+N EL+E EN+ K + DKD YQ + +EA +R+ I L +
Sbjct: 581 LNRELQERNRILENS-------KSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITS 633
Query: 354 YSSSVINVNTNIEEKEEEVTEA---IRETKSSKNELH-SLSKMLEDLRRVYDQLTWKQKS 409
V ++ N+E+ E E EA + ++ KN L L+ L+ L++ +Q + K
Sbjct: 634 LQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKV 693
Query: 410 HENQYLEAVNDFYAAKKTWDIELSDVAK-DFSAISLACTKLTEDNKK---LEIDINKITV 465
+ + + AK E+ K + A A ++ + K+ L++D+ +
Sbjct: 694 TKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQ 753
Query: 466 KTNESIRKKSKYESEIKYLTI-MKLKNDKHL---KNIYKEAYRIGTLFHLTKHKTDE--- 518
K K + E E+K LT+ ++ +++K L + +A+ L L K E
Sbjct: 754 KLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINT 813
Query: 519 -------MEDKIAEVRRKFKGREEFLKKL---------------TQGEVAAGMVLQKKLY 556
+E ++A++ ++++G E +++L TQ + + +K
Sbjct: 814 LLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRE 873
Query: 557 SIYEVQALE-RKELIKNRAICAMSLAE--------LQEPLLQLEDEAERIRS------LD 601
++ ++Q L+ KE + + A + AE L+E +L E+++ S D
Sbjct: 874 NLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITD 933
Query: 602 KEHSVSK----RSAIFKDLEATKSKTMIFYAKINELNEELKAKEEE-----KKSFDQTL- 651
K+H+VS+ S + KD+E + + K+ + EE K ++EE K +F++ +
Sbjct: 934 KDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNIN 993
Query: 652 --------------EILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLL 697
EI+ K + K+ + Q + + +K + + +E ++F ++
Sbjct: 994 TERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRK-LQLELNQEREKFNQMV 1052
Query: 698 AVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTS 752
QK L D Q A +EE +LQ+ ++ + + K L L S
Sbjct: 1053 VKHQKELNDMQ---AQLVEE----CAHRNELQMQLASKESDIEQLRAKLLDLSDS 1100
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 85.9 bits (211), Expect = 1e-16
Identities = 138/695 (19%), Positives = 308/695 (44%), Gaps = 58/695 (8%)
Query: 153 DEKCPEL---KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWK 209
+E+C +L K ++E + E ++ + + +AE K+++ +K D +
Sbjct: 903 EERCDQLIKAKFQLEAKIKEVTE--RAEDEEEINAELTAKKRKLEDECSELKKDIDDL-- 958
Query: 210 LQELPLA-VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAK----IQADID 264
EL LA V+KE A + V L L + ++K L+EA+ + +QA+ D
Sbjct: 959 --ELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEED 1016
Query: 265 YMNEHGPLLDSKQNQELQDLKNHYKKKMEV-MDLHRKVNEELEEALEACENARLKAQQIK 323
+N SK Q+++DL++ +++ ++ +DL R +LE L+ + + L + K
Sbjct: 1017 KVNSLNKT-KSKLEQQVEDLESSLEQEKKLRVDLERN-KRKLEGDLKLAQESILDLENDK 1074
Query: 324 EEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSS- 382
+++D+ + + + + ++ +L + + + IEE EEE+ EA R T++
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEI-EAERATRAKT 1133
Query: 383 -------KNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDF-----------YAA 424
EL LS+ LE+ V K E ++L+ D A
Sbjct: 1134 EKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAAL 1193
Query: 425 KKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYL 484
+K ++++ + + KL ++ + +++I+ ++ + ES+ KSK E
Sbjct: 1194 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLS-SSMESV-SKSKANLEKICR 1251
Query: 485 TIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGE 544
T+ ++ KN +E R +L LT K+ ++ + E+ R+ + +E + +L++ +
Sbjct: 1252 TLEDQLSEARGKN--EEIQR--SLSELTTQKS-RLQTEAGELSRQLEEKESIVSQLSRSK 1306
Query: 545 VAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEH 604
A ++ + LE + KN A+ + LL+ + E E+ + +
Sbjct: 1307 QAFTQQTEEL------KRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQR 1360
Query: 605 SVSKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFK 664
++SK ++ TK +T + EL E K + + ++ +E + K ++
Sbjct: 1361 ALSKANSEVAQWR-TKYETDAI-QRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKT 1418
Query: 665 REHAQTVFDHYM---QEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRL 721
++ Q + M + + ++ + F +LA + +++Q + SL+E+ L
Sbjct: 1419 KQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSL 1478
Query: 722 AQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRD-KKQLCQLQRRMHTLWQEHFKLVVLF 780
+ E +L+ + + D + + +L+ I D +Q+ + + +H L + ++ +
Sbjct: 1479 STELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEK 1538
Query: 781 SQMRLANFQTDS--QESIQKILAVQEESSNLMQHI 813
+ ++LA + ++ + KIL +Q E + + I
Sbjct: 1539 ADIQLALEEAEAALEHEEAKILRIQLELTQVKSEI 1573
Score = 81.3 bits (199), Expect = 3e-15
Identities = 161/788 (20%), Positives = 316/788 (40%), Gaps = 123/788 (15%)
Query: 133 LKEDWSVTTPVKEV-KPGEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQ 191
+K + + +KEV + E +E EL + L E L K ++ + K++
Sbjct: 910 IKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEK 969
Query: 192 RSRKNMINMKIDSWS-----VWKLQELPLAVQKEHEAYLSDV--------------IELQ 232
+ +N + + S + KL A+Q+ H+ L D+ +L+
Sbjct: 970 HATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLE 1029
Query: 233 WHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKM 292
+ED + L+ +K + +LE K++ D+ E L++ + Q + LK KK
Sbjct: 1030 QQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLK---KKDF 1086
Query: 293 EVMDLHRKVNEELEEALE---ACENARLKAQQIKEEIDKDIY---QDEKTIEAYKREIYQ 346
E L KV +E L+ + + + ++++EEI+ + + EK Y RE+ +
Sbjct: 1087 EYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEE 1146
Query: 347 LNSLFDH---YSSSVINVNT-----------NIEE---KEEEVTEAIRETKSSKNELHSL 389
L+ + +S+ I +N ++EE + E + A+R K + + L
Sbjct: 1147 LSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALR--KKHADSVAEL 1204
Query: 390 SKMLEDLRRVYDQLTWKQKSHE-------NQYLEAVNDFYAAK----KTWDIELSDVAKD 438
+ +++L+RV +L K+KS + +E+V+ A +T + +LS+
Sbjct: 1205 GEQIDNLQRVKQKLE-KEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGK 1263
Query: 439 FSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNI 498
I + ++LT +L+ + +++ + E S+ + T + + L+
Sbjct: 1264 NEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEE 1323
Query: 499 YKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSI 558
K + ++H D + ++ E + +G+ E + L++ K
Sbjct: 1324 NKAKNALAHALQSSRHDCDLLREQYEEEQ---EGKAELQRALSKANSEVAQWRTK----- 1375
Query: 559 YEVQALER-KELIKNRAICAMSLAELQEPL-------LQLEDEAERIRS------LDKEH 604
YE A++R +EL + + A L + +E + LE +R++ +D E
Sbjct: 1376 YETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVER 1435
Query: 605 SVSKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFK 664
+ S +A+ K + K E EL+A +E +S L LKN + +
Sbjct: 1436 ANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQ 1495
Query: 665 REHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVR----------QKTLQDTQKIIADS 714
E + + QE D E+I E + L R Q L++ + +
Sbjct: 1496 LETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHE 1555
Query: 715 LEENLRLAQEYQQLQITF---LKEKD--------NYFNIYDK-QLSLDTSIRDKKQLCQL 762
+ LR+ E Q++ + EKD NY + Q +LD +R + + +L
Sbjct: 1556 EAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRL 1615
Query: 763 QRRM------------HTLWQEHFKLVVLFS---QMRLANFQTDS----QESIQKILAVQ 803
+++M H Q L L S Q++ D QE +++ LA+
Sbjct: 1616 KKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIV 1675
Query: 804 EESSNLMQ 811
E +NL+Q
Sbjct: 1676 ERRANLLQ 1683
Score = 71.6 bits (174), Expect = 3e-12
Identities = 144/732 (19%), Positives = 294/732 (40%), Gaps = 132/732 (18%)
Query: 96 VNKMISHIQDVESKIQ-EHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVK--EVKPGEKR 152
+ ++ + I+++E +I+ E R +T + ++L E V +++ +KR
Sbjct: 1109 IKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKR 1168
Query: 153 DEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQE 212
+ + +L++++E + ++ +L AD+ L +Q ID+ LQ
Sbjct: 1169 EAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQ----------IDN-----LQR 1213
Query: 213 LPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPL 272
+ ++KE E + ++D ++ ++ K K LE+ ++ D ++E
Sbjct: 1214 VKQKLEKEKS-------EFKLEIDDLSSSMESVSKSKANLEKICRTLE---DQLSEARGK 1263
Query: 273 LDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQ 332
+ Q + + + E +L R++ EE E + ++ Q EE+ + + +
Sbjct: 1264 NEEIQRSLSELTTQKSRLQTEAGELSRQL-EEKESIVSQLSRSKQAFTQQTEELKRQLEE 1322
Query: 333 DEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNEL-HSLSK 391
+ K N+L SS + + E+ EEE + K EL +LSK
Sbjct: 1323 ENKA----------KNALAHALQSSRHDCDLLREQYEEE--------QEGKAELQRALSK 1364
Query: 392 MLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTE 451
++ + W+ K +E ++ + AKK L D + A++ C L +
Sbjct: 1365 ANSEVAQ------WRTK-YETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEK 1417
Query: 452 DNKKLEIDINKITVKTNES-------IRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYR 504
++L+ ++ + V + +K+ ++ + ++ L+ KE+
Sbjct: 1418 TKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRS 1477
Query: 505 IGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQAL 564
+ T K+ +E D++ V+R+ K E+ + LT+ G +
Sbjct: 1478 LSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIH------------ 1525
Query: 565 ERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSKTM 624
EL K+R + A++Q L +EAE EH +K I +L KS+
Sbjct: 1526 ---ELEKSRKQIELEKADIQLAL----EEAEAA----LEHEEAKILRIQLELTQVKSE-- 1572
Query: 625 IFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEE 684
KI E +EE+ E+ K+++ +T+E MQ D E
Sbjct: 1573 -IDRKIAEKDEEI---EQLKRNYQRTVET----------------------MQSALDAEV 1606
Query: 685 RIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYD 744
R E A+R K +K+ D E ++L+ +Q T + + D
Sbjct: 1607 RSRNE--------AIRLK-----KKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKD 1653
Query: 745 KQLSLDTSIRD----KKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQ--ESIQK 798
QL LD ++R K+QL ++RR + L E +L Q A + + +S ++
Sbjct: 1654 TQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNER 1713
Query: 799 ILAVQEESSNLM 810
+ + ++++L+
Sbjct: 1714 VQLLHTQNTSLI 1725
Score = 58.2 bits (139), Expect = 3e-08
Identities = 112/586 (19%), Positives = 241/586 (41%), Gaps = 69/586 (11%)
Query: 271 PLLDSKQNQ-ELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQ-QIKEEIDK 328
PLL S + + E+ +K ++K + + +ELEE L + Q Q++ E +
Sbjct: 839 PLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESEN 898
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHS 388
+ +E+ + K + +QL + + V E++EE E + + ++E
Sbjct: 899 LLDAEERCDQLIKAK-FQLEA-------KIKEVTERAEDEEEINAELTAKKRKLEDECSE 950
Query: 389 LSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTK 448
L K ++DL ++ ++ + EN+ K ELS + + + ++
Sbjct: 951 LKKDIDDLELTLAKVEKEKHATENKV-----------KNLTEELSGLDETIAKLTREKKA 999
Query: 449 LTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLK-NIYKEAYRIGT 507
L E +++ D+ K N + KSK E +++ L L+ +K L+ ++ + ++
Sbjct: 1000 LQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLE-SSLEQEKKLRVDLERNKRKLEG 1058
Query: 508 LFHLTKHKTDEMEDKIAEVRRKFKGRE-EF--LKKLTQGEVAAGMVLQKKLYSI------ 558
L + ++E+ ++ + K ++ E+ L+ + E G+ QKK+ +
Sbjct: 1059 DLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEE 1118
Query: 559 ----YEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIF- 613
E + R + K R+ A L EL E L +EA + S E + KR A F
Sbjct: 1119 LEEEIEAERATRAKTEKQRSDYARELEELSERL----EEAGGVTSTQIELN-KKREAEFL 1173
Query: 614 ---KDLEATKSKTMIFYA--------KINELNEEL-------KAKEEEKKSFDQTLEILK 655
+DLE + A + EL E++ + E+EK F ++ L
Sbjct: 1174 KLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLS 1233
Query: 656 NKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSL 715
+ ++ + + + + + + + EE QR L ++ LQ ++ L
Sbjct: 1234 SSMESVSKSKANLEKICRTLEDQLSEARGK-NEEIQRSLSELTTQKSRLQTEAGELSRQL 1292
Query: 716 EENLRLAQEYQQLQITFLKEKDNYFNIYDKQ----LSLDTSIRDKKQLCQLQRRMHTLWQ 771
EE + + + + F ++ + +++ +L +++ + C L R + Q
Sbjct: 1293 EEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQ 1352
Query: 772 E---HFKLVVLFSQMRLANFQTDSQ-ESIQKILAVQEESSNLMQHI 813
E + + + +A ++T + ++IQ+ ++E L Q +
Sbjct: 1353 EGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1398
Score = 57.0 bits (136), Expect = 7e-08
Identities = 110/582 (18%), Positives = 234/582 (40%), Gaps = 70/582 (12%)
Query: 24 QEVKALREKAWSRTN----------EGNAMSQSLVLYGASKENSEGFHESKMTNTEGVNK 73
QE KA ++A S+ N E +A+ ++ L A K+ ++ +S+ E VN
Sbjct: 1352 QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSE-EQVEAVNA 1410
Query: 74 GIYFSYPCRRHSCAVVN---IPAPCVNKMISHIQDVESKIQEHLKRFETSFEEWSRTSST 130
++ V + N + + + + + L ++T EE S+
Sbjct: 1411 KCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEE-SQAELE 1469
Query: 131 KDLKEDWSVTTPVKEVKPGE----------KRDEKCPELKQEMETL----------LSEA 170
LKE S++T + ++K KR+ K L+QE+ L + E
Sbjct: 1470 ASLKESRSLSTELFKLKNAYEEALDQLETVKRENK--NLEQEIADLTEQIAENGKTIHEL 1527
Query: 171 IRLIKSLETDRAD-------AEEALKQQRSRKNMINMK---IDSWSVWKLQELPLAVQKE 220
+ K +E ++AD AE AL+ + ++ I ++ + S K+ E +++
Sbjct: 1528 EKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQL 1587
Query: 221 HEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQE 280
Y V +Q L+ + + K ++E +I+ + + N ++ +
Sbjct: 1588 KRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQA----AETLKH 1643
Query: 281 LQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAY 340
L+ ++ K +D + E+L+E L E Q EE+ + Q E+ +
Sbjct: 1644 LRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLA 1703
Query: 341 KREIYQLNS---LFDHYSSSVIN----VNTNIEEKEEEVTEAIRETKSS----KNELHSL 389
++E+ N L ++S+I+ + T++ + + EV +A R+ +++ K +
Sbjct: 1704 EQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDA 1763
Query: 390 SKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKL 449
+ M E+L++ D ++ +N + + + + L K KL
Sbjct: 1764 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQ-------KL 1816
Query: 450 TEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLF 509
++LE ++ K ES++ KYE +K LT ++ K++ + ++
Sbjct: 1817 ETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKV 1876
Query: 510 HLTKHKTDEMEDKIAEVRRKF-KGREEFLKKLTQGEVAAGMV 550
K + +E +++ KF K + E + + ++A V
Sbjct: 1877 KSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQV 1918
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 85.5 bits (210), Expect = 2e-16
Identities = 155/793 (19%), Positives = 320/793 (40%), Gaps = 102/793 (12%)
Query: 98 KMISHIQDVESKI-QEHLKRFETSFEEWSRTSSTKDLKEDWSVTTP-----VKEVKPGEK 151
KM +HIQD+E ++ +E R + E+ + + K ++E+ + +KE K E
Sbjct: 947 KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMED 1006
Query: 152 RDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQ---RSRKNMINMKIDSWSV- 207
R +C E E ++ E +D EE LK++ R K+D +
Sbjct: 1007 RIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTD 1066
Query: 208 ---------WKLQELPLAVQKEHE------------------------AYLSDVIELQWH 234
++ EL L + K+ E + + ELQ
Sbjct: 1067 LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQED 1126
Query: 235 LEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPL---LDSKQNQELQDL------- 284
E + EKQK +L E ++ +++ + L +K+ QE+ +L
Sbjct: 1127 FESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE 1186
Query: 285 -KNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEID---KDIYQDEKTIEAY 340
KNH + ++ H EEL E LE + + ++ K+ ++ K++ + K ++
Sbjct: 1187 TKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQV 1246
Query: 341 KREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVY 400
K E D + V ++ + E + E + +NEL ++S +LE+ +
Sbjct: 1247 KAESEHKRKKLD---AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKG 1303
Query: 401 DQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDI 460
+ S E+Q L+ + + + LS + + + E+ ++ ++
Sbjct: 1304 IKFAKDAASLESQ-LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNL 1362
Query: 461 NK-ITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKN-------IYKEAYRIGTLFHLT 512
K + ++ K K + ++ + ++ K LK+ + ++A L
Sbjct: 1363 EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTK 1422
Query: 513 KHKTDEMEDKIAEV---RRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKEL 569
E++D ++ R+ E+ KK Q ++ ++K S + +R E
Sbjct: 1423 NRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ------LLAEEKSISARYAEERDRAEA 1476
Query: 570 -IKNRAICAMSLAELQEPLLQLEDEAERIRS---LDKEHSVSKRSAIFKDL-EATKSKTM 624
+ + A+SLA E L+ ++E ER D E +S + + K++ E KSK
Sbjct: 1477 EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA 1536
Query: 625 I------FYAKINELNEELKAKEEEKKSFDQTLEILKNKF-ITMRFKREHAQTVFDHYMQ 677
+ ++ EL +EL+A E+ K + ++ +K +F ++ + E + ++
Sbjct: 1537 LEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIK 1596
Query: 678 EKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKD 737
+ ++ E + ED+R + LAV K +I LE + A + + I L++
Sbjct: 1597 QVRELEAEL--EDERKQRALAVASK---KKMEIDLKDLEAQIEAANKARDEVIKQLRKLQ 1651
Query: 738 NYFNIYDKQLSLDTSIRDK--KQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQES 795
Y ++L + RD+ Q + ++++ +L E +L Q LA+ + + +
Sbjct: 1652 AQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAE-----ILQLQEELASSERARRHA 1706
Query: 796 IQKILAVQEESSN 808
Q+ + +E +N
Sbjct: 1707 EQERDELADEITN 1719
Score = 76.3 bits (186), Expect = 1e-13
Identities = 141/693 (20%), Positives = 291/693 (41%), Gaps = 121/693 (17%)
Query: 108 SKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLL 167
SK+Q L T EE + K K+ S+ + +++ + E E E +Q++ L
Sbjct: 1283 SKLQNELDNVSTLLEE-AEKKGIKFAKDAASLESQLQDTQ--ELLQE---ETRQKLN--L 1334
Query: 168 SEAIRLIK----SLETDRADAEEALKQQRSRKNMINMKI---------DSWSVWKLQELP 214
S IR ++ SL+ + + EEA K + + ++ D ++ L+E
Sbjct: 1335 SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAK 1394
Query: 215 LAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLD 274
+ K+ EA L LE+KA EK K L++ + D+D+ + L+
Sbjct: 1395 KKLLKDAEA-------LSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLE 1447
Query: 275 SKQNQ------ELQDLKNHYKKKMEVMDLHRKVNE--------ELEEALEACE-----NA 315
KQ + E + + Y ++ + + + E LEEALEA E N
Sbjct: 1448 KKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNK 1507
Query: 316 RLKA-----QQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSV-------INVNT 363
+L+A K+++ K++++ EK+ A ++++ ++ + + + + +
Sbjct: 1508 QLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567
Query: 364 NIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYA 423
N++ + + E +T+ +NE +++ +R + +L ++K Q AV A
Sbjct: 1568 NMQAMKAQF-ERDLQTRDEQNE-EKKRLLIKQVRELEAELEDERK----QRALAV----A 1617
Query: 424 AKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKY 483
+KK +I+L D+ A + A ++ + +KL+ + + E+ + + ++ K
Sbjct: 1618 SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK- 1676
Query: 484 LTIMKLKNDKHLKNIYKEAYR----IGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKK 539
+++K LK++ E + + + +H E ++ E+ G+ L +
Sbjct: 1677 ------ESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDE 1730
Query: 540 LTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRS 599
+ E + ++ + E Q+ EL+ +R LQ L E AER +
Sbjct: 1731 KRRLEARIAQLEEE----LEEEQS--NMELLNDR----FRKTTLQVDTLNAELAAERSAA 1780
Query: 600 LDKEHSVSKRSAIFKDLEAT------------KSKTMIFYAKINELNEELKAKEEEK--- 644
+++ + K+L+A K+ AKI +L E+L+ + +E+
Sbjct: 1781 QKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAA 1840
Query: 645 -KSFDQTLEILKNKFITMRFKREHAQTVFDHYMQE-------KKDCEERIFEEDQRFRVL 696
K +T + LK F+ + +R HA D Y ++ K + ++ E ++
Sbjct: 1841 NKLVRRTEKKLKEIFMQVEDERRHA----DQYKEQMEKANARMKQLKRQLEEAEEEATRA 1896
Query: 697 LAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQ 729
A R+K Q+ + D+ E N L++E L+
Sbjct: 1897 NASRRK----LQRELDDATEANEGLSREVSTLK 1925
Score = 70.5 bits (171), Expect = 6e-12
Identities = 143/765 (18%), Positives = 305/765 (39%), Gaps = 126/765 (16%)
Query: 137 WSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKN 196
W V T VK + +++E+ +E+ + + ++ LE ++ L+++
Sbjct: 835 WRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAE 894
Query: 197 MINMKIDSWSVWKLQELPLAVQK-EHEAYLSDV------------------IELQWHLED 237
+ + + ++ + LA +K E E L D+ ++Q H++D
Sbjct: 895 QLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQD 954
Query: 238 KANQLQHFE--KQKTELEEANAKIQADIDYMNEHGPLLDSKQNQ---------------- 279
QL E +QK +LE+ A +A I M E LL+ + ++
Sbjct: 955 LEEQLDEEEGARQKLQLEKVTA--EAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012
Query: 280 -ELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQ------ 332
+L + + K ++ + + +LEE L+ E R + ++ K ++D +
Sbjct: 1013 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA 1072
Query: 333 ------DEKTIEAYKRE--------------IYQLNSL--FDHYSSSVINVNTNIEEKEE 370
DE ++ K+E +++ N+L + + + + E ++
Sbjct: 1073 ELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKA 1132
Query: 371 EVTEAIRETKSSKNELHSLSKMLED----------LRRVYDQ--------LTWKQKSHEN 412
+A ++ + EL +L LED LR +Q L + K+HE
Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEA 1192
Query: 413 QYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTK--LTEDNKKLEIDINKITVKTNES 470
Q ++ + +A E + AK F A +L K L DNK+L ++ + ES
Sbjct: 1193 Q-IQDMRQRHATALEELSEQLEQAKRFKA-NLEKNKQGLETDNKELACEVKVLQQVKAES 1250
Query: 471 IRKKSKYESEIKYLTIMKLKNDK-------HLKNIYKEAYRIGTLFHLTKHKTDEMEDKI 523
K+ K +++++ L + D+ + E + TL + K +
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDA 1310
Query: 524 AEVRRKFKGREEFLKKLTQGEVAAG---MVLQKKLYSIYEVQALERKELIKNRAICAMSL 580
A + + + +E L++ T+ ++ L+++ S+ E Q E +E KN ++L
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE-EEEEARKNLEKQVLAL 1369
Query: 581 -AELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSK---TMIFYAKINELNEE 636
++L + +++D+ I SL++ + + KD EA + + Y K+ +
Sbjct: 1370 QSQLADTKKKVDDDLGTIESLEE-----AKKKLLKDAEALSQRLEEKALAYDKLEKTKNR 1424
Query: 637 LKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVL 696
L+ + + D T+++ + + +++ Q FD + E+K R EE R
Sbjct: 1425 LQQELD-----DLTVDLDHQRQVASNLEKK--QKKFDQLLAEEKSISARYAEERDRAEAE 1477
Query: 697 LAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQI---TFLKEKD----NYFNIYDKQLSL 749
++ + + ++LE ++ +QL+ + KD N + + +L
Sbjct: 1478 AREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRAL 1537
Query: 750 DTSIRD-KKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQ 793
+ + + + QL +L+ + +L V M+ A F+ D Q
Sbjct: 1538 EQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK-AQFERDLQ 1581
Score = 34.3 bits (77), Expect = 0.49
Identities = 46/194 (23%), Positives = 94/194 (48%), Gaps = 27/194 (13%)
Query: 153 DEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKN--------MINMKIDS 204
+E+ E + ME LL++ R +L+ D +AE A ++ ++K+ N ++ +
Sbjct: 1742 EEELEEEQSNME-LLNDRFRKT-TLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKA 1799
Query: 205 WSVWKLQELPLAVQKEHEAYLS----DVIELQWHLEDKANQLQHFEK--QKTE--LEEAN 256
KLQEL AV+ + +A +S + +L+ LE +A + K ++TE L+E
Sbjct: 1800 ----KLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIF 1855
Query: 257 AKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDL----HRKVNEELEEALEAC 312
+++ + + +++ ++ K N ++ LK ++ E RK+ EL++A EA
Sbjct: 1856 MQVEDERRHADQYKEQME-KANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEAN 1914
Query: 313 ENARLKAQQIKEEI 326
E + +K +
Sbjct: 1915 EGLSREVSTLKNRL 1928
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 85.5 bits (210), Expect = 2e-16
Identities = 137/684 (20%), Positives = 274/684 (40%), Gaps = 102/684 (14%)
Query: 160 KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQK 219
K+++E L + I LE D+ EE LK++ + + KID V LQ QK
Sbjct: 1056 KRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQ-----FQK 1110
Query: 220 EHEAYLSDVIELQWHLEDKANQLQHFEKQKTE-----------LEEANAKIQADIDYMNE 268
+ + + + EL+ +E + EKQ+++ LEEA+ A I+ MN+
Sbjct: 1111 KIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIE-MNK 1169
Query: 269 HGPLLDSKQNQELQDLK-NHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEID 327
K ++L++ H + EL E ++ + + K ++ K E+
Sbjct: 1170 KREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELK 1229
Query: 328 KDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELH 387
+I IEA + S + +V + + I+ K+E+ T+ I + K L
Sbjct: 1230 MEIDDMASNIEALSKS----KSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQ 1285
Query: 388 S----LSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAIS 443
+ LS +E+ + QLT K K Q LE + +E AK+ A +
Sbjct: 1286 TQNGELSHRVEEKESLISQLT-KSKQALTQQLEELKR--------QMEEETKAKNAMAHA 1336
Query: 444 LACTK--------LTEDNKKLEIDINKITVKTNESIRK-KSKYESEIKYLTIMKLKNDKH 494
L ++ E+ ++ + ++ + K N + + ++KYE++ T + K
Sbjct: 1337 LQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1396
Query: 495 LKNIYKEAYRIGTLFHLTKHKTDEMEDKIA---EVRRKFKGREEFLKKLTQGEVAAGMVL 551
L +EA + T+ K A + +++ +G E L + + A L
Sbjct: 1397 LAQRLQEA----------EENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATL 1446
Query: 552 QKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSA 611
KK + +V A +++L +++A L Q+ L E ++R+ +E
Sbjct: 1447 DKKQRNFDKVLAEWKQKLDESQA----ELEAAQKESRSLSTELFKMRNAYEE-------- 1494
Query: 612 IFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTV 671
+ LE + + +I++L E++ + + ++T ++++ + ++ E +
Sbjct: 1495 VVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGS 1554
Query: 672 FDH-----------YMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKII--------- 711
+H Q K + + ++ E+D+ L Q+ + Q ++
Sbjct: 1555 LEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRND 1614
Query: 712 ---------ADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRD----KKQ 758
D E ++L +Q+ T + + D QL LD ++R K+Q
Sbjct: 1615 ALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQ 1674
Query: 759 LCQLQRRMHTLWQEHFKLVVLFSQ 782
L ++RR L +E ++ V Q
Sbjct: 1675 LAIVERRNGLLLEELEEMKVALEQ 1698
Score = 75.9 bits (185), Expect = 1e-13
Identities = 133/697 (19%), Positives = 294/697 (42%), Gaps = 97/697 (13%)
Query: 122 EEWSRTSSTKDLKEDWS-----VTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKS 176
E+ + + K+L E+ + ++ KE K ++ ++ + Q E ++ I++
Sbjct: 971 EKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAK 1030
Query: 177 LETDRADAEEALKQQRS---------RKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSD 227
LE D E +L+Q++ RK ++K+ S+ L+ ++++ + +
Sbjct: 1031 LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFE 1090
Query: 228 VIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNH 287
+ +LQ ++D+ F+K+ EL+ +++ +I+ EH L +K ++ DL
Sbjct: 1091 LSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIE--AEH--TLRAKIEKQRSDLARE 1146
Query: 288 YKKKMEVMDLHRKVNEELEEA-------LEACENARLKAQQIKEEIDKDIYQDEKTIEAY 340
+ +++E LEEA +E + + Q+++ ++++ Q E T
Sbjct: 1147 LE----------EISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATL 1196
Query: 341 KREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRR-- 398
+++ Q +S+ + + N+ ++ E+E +E E + + +LSK ++ R
Sbjct: 1197 RKK--QADSVAE-LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTC 1253
Query: 399 --VYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKL 456
V DQ + + K+ + Q + ++D K + +++ ++LT+ + L
Sbjct: 1254 RTVEDQFS-EIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQAL 1312
Query: 457 EIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKT 516
+ E ++++ + E++ K L++ +H ++ +E Y
Sbjct: 1313 TQQL--------EELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYE------------ 1352
Query: 517 DEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAIC 576
+E E K R K E + T+ E A + ++L + A +E +N
Sbjct: 1353 EEQEAKAELQRALSKANSEVAQWRTKYETDA-IQRTEELEEAKKKLAQRLQEAEENTETA 1411
Query: 577 AMSLAELQEPLLQLEDEAERI-RSLDKEH----SVSKRSAIFKDLEATKSKTMIFYAKIN 631
A L++ +L+ E E + R L++ H ++ K+ F + A + K++
Sbjct: 1412 NSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAE------WKQKLD 1465
Query: 632 ELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFE--- 688
E EL+A ++E +S L ++N + + + E + + +E D E+I E
Sbjct: 1466 ESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGK 1525
Query: 689 ---EDQRFRVLLAVRQKTLQDTQKIIADSLEEN----LRLAQEYQQLQITF---LKEKDN 738
E ++ + L+ + LQ + + SLE LR+ E Q++ + EKD
Sbjct: 1526 NLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDE 1585
Query: 739 YFNIYDK---------QLSLDTSIRDKKQLCQLQRRM 766
+ Q LD IR + +L+++M
Sbjct: 1586 EIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKM 1622
Score = 67.4 bits (163), Expect = 5e-11
Identities = 139/699 (19%), Positives = 272/699 (38%), Gaps = 106/699 (15%)
Query: 155 KCPELKQEMETLLSEAIRLIKSL---ETDRADAEEALKQQRSRKNMINMKIDSWS--VWK 209
K E ++EM T+ + R + L E R + EE + KN + +++ S + +
Sbjct: 845 KSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMD 904
Query: 210 LQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEH 269
+E + K + V EL LE++ +K LE+ + ++ DID +
Sbjct: 905 AEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLE-- 962
Query: 270 GPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKD 329
L +K +E +N K E M LEE + + Q+ ++ D
Sbjct: 963 --LTLTKVEKEKHATENKVKNLSEEM-------TALEENISKLTKEKKSLQEAHQQTLDD 1013
Query: 330 IYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSL 389
+ +E + + +I +N +E++ +++ ++ + K
Sbjct: 1014 LQVEEDKV------------------NGLIKINAKLEQQTDDLEGSLEQEK--------- 1046
Query: 390 SKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKL 449
K+ DL R +L K + ++ ND IE K+F L
Sbjct: 1047 -KLRADLERAKRKLEGDLKMSQESIMDLEND------KQQIEEKLKKKEFELSQLQAK-- 1097
Query: 450 TEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLF 509
+D + + K K E + + E EI+ ++ K +K ++ +E I
Sbjct: 1098 IDDEQVHSLQFQK---KIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERL 1154
Query: 510 HLTKHKTDEMEDKIAEVRRKFKGREEFLKKLT-QGEVAAGMVLQKKLYSIYEV-QALERK 567
T + + +F+ L++ T Q E A + +K+ S+ E+ + ++
Sbjct: 1155 EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNL 1214
Query: 568 ELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSA-----IFKDLEA-TKS 621
+ +K + E E ++++D A I +L K S +R+ F +++A +
Sbjct: 1215 QRVKQKL-----EKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQ 1269
Query: 622 KTMIFY------AKINELNEELKAKEEEKKS-----------FDQTLEILKNKFITMRFK 664
+T + + A++ N EL + EEK+S Q LE LK + +
Sbjct: 1270 QTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQM----EE 1325
Query: 665 REHAQTVFDHYMQEKK-DCE--ERIFEEDQRF-----RVLLAVRQKTLQDTQKIIADSLE 716
A+ H +Q + DC+ +EE+Q R L + Q K D+++
Sbjct: 1326 ETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQ 1385
Query: 717 ENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKKQL-CQLQRRMHTLWQEHFK 775
L + ++L + ++N K SL+ + K++L +++ M L + H
Sbjct: 1386 RTEELEEAKKKLAQRLQEAEENTETANSKCASLE---KTKQRLQGEVEDLMRDLERSHTA 1442
Query: 776 LVVLFSQMR-----LANFQTDSQESIQKILAVQEESSNL 809
L + R LA ++ ES ++ A Q+ES +L
Sbjct: 1443 CATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSL 1481
Score = 58.5 bits (140), Expect = 2e-08
Identities = 95/505 (18%), Positives = 209/505 (41%), Gaps = 78/505 (15%)
Query: 271 PLLDSKQ-NQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQ-QIKEEIDK 328
PLL S + +E+ +K +++ E + +ELEE + + + Q Q++ E +
Sbjct: 842 PLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETEN 901
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHS 388
+ +E+ K +I + V + +EE+EE +E + + ++ +++ S
Sbjct: 902 LMDAEERCEGLIKSKIL--------LEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSS 953
Query: 389 LSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTK 448
L + ++DL ++ ++ + EN+ + A ++ +S + K+ ++ A +
Sbjct: 954 LKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEE----NISKLTKEKKSLQEAHQQ 1009
Query: 449 LTEDNKKLEIDIN---KITVKTNESI------------------RKKSKYESEIKYL--T 485
+D + E +N KI K + R K K E ++K +
Sbjct: 1010 TLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQES 1069
Query: 486 IMKLKNDKHL--KNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQG 543
IM L+NDK + + K+ + + L + K D+ + + ++K K + +++L +
Sbjct: 1070 IMDLENDKQQIEEKLKKKEFELSQL----QAKIDDEQVHSLQFQKKIKELQARIEELEE- 1124
Query: 544 EVAAGMVLQKKLYSIYEVQALERKELI------------------KNRAICAMSLAELQE 585
E+ A L+ K+ A E +E+ K A +L+E
Sbjct: 1125 EIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEE 1184
Query: 586 PLLQLEDEAERIRSLDKE------HSVSKRSAIFKDLEATKSKTMIFYAKINELNEELKA 639
LQ E A +R + + + + LE KS+ + +I+++ ++A
Sbjct: 1185 ATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKM---EIDDMASNIEA 1241
Query: 640 KEEEKKSFDQTLEILKNKFITMRFKRE-HAQTVFDHYMQEKK------DCEERIFEEDQR 692
+ K + ++T ++++F ++ K E Q + D MQ+ + + R+ E++
Sbjct: 1242 LSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESL 1301
Query: 693 FRVLLAVRQKTLQDTQKIIADSLEE 717
L +Q Q +++ EE
Sbjct: 1302 ISQLTKSKQALTQQLEELKRQMEEE 1326
Score = 50.4 bits (119), Expect = 7e-06
Identities = 88/465 (18%), Positives = 194/465 (41%), Gaps = 42/465 (9%)
Query: 98 KMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCP 157
KM + ++V ++ E L+R + +E DL E + T K ++ EK +
Sbjct: 1487 KMRNAYEEVVDQL-ETLRRENKNLQE-----EISDLTEQIAETG--KNLQEAEKTKKLVE 1538
Query: 158 ELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAV 217
+ K +++ L E ++ E+ + L Q +S + ++ D ++++L
Sbjct: 1539 QEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDE----EIEQLKRNS 1594
Query: 218 QKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQ 277
Q+ EA L V++ + + A +L+ +K + +L E ++ M E L + Q
Sbjct: 1595 QRAAEA-LQSVLDAEIRSRNDALRLK--KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQ 1651
Query: 278 NQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTI 337
Q L+D + H +D + NE+L+E L E + EE+ + Q E+T
Sbjct: 1652 GQ-LKDSQLH-------LDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTR 1703
Query: 338 EAYKREIYQLN---SLFDHYSSSVINVNTNIE--------EKEEEVTEAIRETKSSKNEL 386
++E+ + L ++S+IN +E E E + E+ + +K +
Sbjct: 1704 RLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAI 1763
Query: 387 HSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLAC 446
+ M E+L++ D ++ +N + + + + L K
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQ------ 1817
Query: 447 TKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIG 506
KL ++LE +++ + E+++ KYE ++K +T ++ K++ + ++
Sbjct: 1818 -KLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQ 1876
Query: 507 TLFHLTKHKTDEMEDKI-AEVRRKFKGREEFLKKLTQGEVAAGMV 550
K + +E E++ ++ R + + E + + ++A V
Sbjct: 1877 AKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQV 1921
Score = 31.6 bits (70), Expect = 3.2
Identities = 59/292 (20%), Positives = 120/292 (41%), Gaps = 68/292 (23%)
Query: 97 NKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTT--------PVKEVKP 148
N+ ++ Q +Q LK + ++ R S +DLKE ++ ++E+K
Sbjct: 1637 NRQMAETQKHLRTVQGQLKDSQLHLDDALR--SNEDLKEQLAIVERRNGLLLEELEEMKV 1694
Query: 149 GEKRDEKCPELKQEMETLLSEAIRLI-----------KSLETD----RADAEEALKQQRS 193
++ E+ L ++ S+ ++L+ K LE D +A+ E ++++ R+
Sbjct: 1695 ALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRN 1754
Query: 194 -----RKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQL--QHFE 246
+K + + + + + K Q+ +++ + V +LQ H D+A QL + +
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQ-HRLDEAEQLALKGGK 1813
Query: 247 KQKTELEEANAKIQADIDYMNEHGPLL--------------------DSKQNQELQDLKN 286
KQ +LE +++ ++D + G D K LQDL +
Sbjct: 1814 KQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVD 1873
Query: 287 H-------YKKKMEVMDLH--------RKVNEELEEALEACENARLKAQQIK 323
YK++ E + R+V ELEEA E + A + +++
Sbjct: 1874 KLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLR 1925
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 85.1 bits (209), Expect = 2e-16
Identities = 140/762 (18%), Positives = 322/762 (42%), Gaps = 86/762 (11%)
Query: 105 DVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVK----------EVKPGEKRDE 154
+ E ++ + FE + EE ++T + + E+ VT + E +E
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEE 907
Query: 155 KCPEL---KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQ 211
+C +L K ++E + E ++ + + +AE K+++ +K D +
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTE--RAEDEEEINAELTAKKRKLEDECSELKKDIDDL---- 961
Query: 212 ELPLA-VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHG 270
EL LA V+KE A + V L + + K+K L+EA+ + D+ +
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKV 1021
Query: 271 PLLD---SKQNQELQDLKNHYKKKMEV-MDLHRKVNEELEEALEACENARLKAQQIKEEI 326
L +K Q++ DL+ +++ ++ MDL R +LE L+ + + + + K+++
Sbjct: 1022 NTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLER-AKRKLEGDLKLAQESTMDTENDKQQL 1080
Query: 327 DKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEV-------TEAIRET 379
++ + + E + + +I +L + + IEE EEE+ +A ++
Sbjct: 1081 NEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1140
Query: 380 KSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDF-----------YAAKKTW 428
EL +S+ LE+ K E ++ + D A +K
Sbjct: 1141 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKH 1200
Query: 429 DIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIK----YL 484
++++ + ++ KL ++ +L+++IN + + K+ +E + L
Sbjct: 1201 ADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQL 1260
Query: 485 TIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEF------LK 538
+ +K K ++ + I + + + L + + ++++K A V + +G++ F LK
Sbjct: 1261 SEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELK 1320
Query: 539 KLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIR 598
+ + E A L L S L R++ + + + AELQ + + E + R
Sbjct: 1321 RQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQE----AKAELQRGMSKANSEVAQWR 1376
Query: 599 SLDKEHSVSKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKF 658
+ + ++ + ++LE K K ++ + E ++A + S ++T + L+N+
Sbjct: 1377 TKYETDAIQRT----EELEEAKKK---LAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEV 1429
Query: 659 --ITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLE 716
+ + +R +A + + ++ + F +LA ++ ++TQ + S +
Sbjct: 1430 EDLMIDVERSNAACI-------------ALDKKQRNFDKVLAEWKQKYEETQAELEASQK 1476
Query: 717 ENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRD-KKQLCQLQRRMHTLWQEHFK 775
E+ L+ E +++ + + D+ + + +L I D +Q+ + + +H L E K
Sbjct: 1477 ESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHEL--EKVK 1534
Query: 776 LVVLFSQMRLANFQTDSQESIQ----KILAVQEESSNLMQHI 813
+ + L +++ S++ KIL +Q E + + I
Sbjct: 1535 KQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEI 1576
Score = 60.5 bits (145), Expect = 6e-09
Identities = 100/528 (18%), Positives = 214/528 (40%), Gaps = 57/528 (10%)
Query: 150 EKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSR-------KNMINMKI 202
E+ + C L ++ + E +A+ E + K+ RS KN +
Sbjct: 1437 ERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESL 1496
Query: 203 DSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQAD 262
D K + L Q+E + E H+ + + + +K+EL+ + + +A
Sbjct: 1497 DHLETLKRENKNL--QQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEAS 1554
Query: 263 IDYMNEHGPLL--DSKQNQELQDLKNHYKKKMEVMDL----HRKVNEELEEALEACENAR 316
+++ E G +L + NQ ++ +K E +D H +V E ++ L+A +R
Sbjct: 1555 LEH--EEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSR 1612
Query: 317 LKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAI 376
A +IK++++ D+ + E + R+ + ++ N +++ + + +AI
Sbjct: 1613 NDALRIKKKMEGDLNEMEIQLNHANRQAAEA-------LRNLRNTQGILKDTQLHLDDAI 1665
Query: 377 RETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVA 436
R K +L + + ++ ++L + E +K + EL D +
Sbjct: 1666 RGQDDLKEQLAMVERRANLMQAEVEELRASLERTER-----------GRKMAEQELLDAS 1714
Query: 437 KDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLK 496
+ + T L KKLE DI++I + + +++ E + K + LK
Sbjct: 1715 ERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELK 1774
Query: 497 NIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLY 556
KE T HL + K + ME + +++ + E+ K + ++ ++L
Sbjct: 1775 ---KEQ---DTSAHLERMKKN-MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1827
Query: 557 SIYEVQALERKELIKNRAICAMSLAEL-------QEPLLQLEDEAERIRSLDKEHSVSKR 609
S E + E +K + EL ++ +L+L+D +++++ K + KR
Sbjct: 1828 SEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAY---KR 1884
Query: 610 SAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNK 657
A E + ++ + AK +L EL+ +E + + L+ K
Sbjct: 1885 QA-----EEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVK 1927
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 84.7 bits (208), Expect = 3e-16
Identities = 136/730 (18%), Positives = 317/730 (43%), Gaps = 95/730 (13%)
Query: 150 EKRDEKCPELKQEMETLLS-EAIRLIK--SLETDRADAEEALKQQRSRKNMINMKIDSWS 206
EK + ++K + E LLS EA + + L+ A+ AL+ ++ N I ++D +
Sbjct: 635 EKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVT 694
Query: 207 VWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYM 266
KLQ+ ++EH + +L+ HL++ + E++ ELE K++AD
Sbjct: 695 A-KLQD-----KQEHCS------QLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD---- 738
Query: 267 NEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARL---KAQQIK 323
+ + + Q LQDL+ + ++ +++++LE E + RL K +
Sbjct: 739 ---SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL 795
Query: 324 EEIDKDIYQDEKTIEAYKREIYQLNS----LFDHYSSSVINVNTNIEEKEEEVTEAIRET 379
E I + + + E+ + K++ L+ + ++ + T +++ + E + E
Sbjct: 796 ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTEL 855
Query: 380 KSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDF 439
+ K++L +S L++ + +++ K K+ L+ K +++ + K+
Sbjct: 856 STVKDKLSKVSDSLKNSKSEFEKENQKGKA---AILDLEKTCKELKHQLQVQMENTLKEQ 912
Query: 440 SAISLACTKLTEDNKKLEIDINKI---TVKTNESIRKKSKYESEIKYLTIMKLKNDKHLK 496
+ + K E + +L++++N + ++ ++++ K E +++ I +LK K
Sbjct: 913 KELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQG-NINELKQSSEQK 971
Query: 497 NIYKEAYRIGTLFHLTKHKTD-----------------EMEDKIAEVRRKFKGREEFLKK 539
EA + G L KT+ ++KI+ ++ ++ +E K+
Sbjct: 972 KKQIEALQ-GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQ 1030
Query: 540 LTQ---GEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQE----------- 585
L G + + ++ L S+ E +L +++LI NR +QE
Sbjct: 1031 LQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQD 1090
Query: 586 ---PLLQLEDEAERIRSLDKEHSVSKRSAI-----FKDLEATKSKTMIFYAKINELNEEL 637
QL++ + ++ + KE S+ ++ + ++E K + +I +LNEEL
Sbjct: 1091 SAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQ---EKEITKLNEEL 1147
Query: 638 KAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLL 697
K+ + E L+ K I + + +Q K D + E+++R + +L
Sbjct: 1148 KSHKLESIKEITNLKDAKQLLIQQKLE-----------LQGKADSLKAAVEQEKRNQQIL 1196
Query: 698 AVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRD-K 756
+ + ++ +++ + +E+ +L E ++ ++ K ++N + + +L+ ++ K
Sbjct: 1197 --KDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVK 1254
Query: 757 KQLCQLQRRMHTLWQEHFKL--VVLFSQMRLANFQTDSQESIQKILAVQEESSNLMQHIL 814
K+ QRR+ L ++ L + + + N Q + + +++ L + E L +L
Sbjct: 1255 KEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVL 1314
Query: 815 GFFQTLTDGT 824
+ L + T
Sbjct: 1315 ELQRKLDNTT 1324
Score = 78.6 bits (192), Expect = 2e-14
Identities = 143/775 (18%), Positives = 318/775 (41%), Gaps = 101/775 (13%)
Query: 104 QDVESKIQEHLKRFETSFEEWSRTSSTKD---LKEDWSVTTPVKEVKPGEKRDEKCPELK 160
Q+V +QE L++ ++S E ++ + T LK++ T K EK +E+ K
Sbjct: 281 QEVAVYVQE-LQKLKSSVNELTQKNQTLTENLLKKEQDYT------KLEEKHNEESVSKK 333
Query: 161 QEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKE 220
TL K L+ + + + + + + + + KL+E V+ +
Sbjct: 334 NIQATLHQ------KDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETK 387
Query: 221 HEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNE-HGPLLDSKQ-- 277
++ ++ +LQ E+K QH + ++E+ + ++K+ + E HG L + +Q
Sbjct: 388 YQHLKAEFKQLQQQREEKE---QHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLS 444
Query: 278 -------NQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDI 330
Q++ DL+ + E + + EL+ L+ + + Q +++ +
Sbjct: 445 SEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKL 504
Query: 331 YQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNI---EEKEEEVTEAIRETKSSKNELH 387
+ + +E R+I + + + + NI E++ E++ I+ + L+
Sbjct: 505 REAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLN 564
Query: 388 SLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACT 447
L + L+ QLT K K+ + +A + + V + + + A
Sbjct: 565 QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLH----------DQVQEQKAHLRAAQD 614
Query: 448 KLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKND--------------- 492
++ LE +N++ + NES K S+ + +IK T + L +
Sbjct: 615 RVL----SLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLD 670
Query: 493 ---KHLKNIYKEAYRIGT-LFHLTKHKTDEME-------------DKIAEVRRKFKGREE 535
L++ +E +I T L +T D+ E +K + +K + E
Sbjct: 671 TAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEG 730
Query: 536 FLKKL---------TQGEVAAGMVLQKKLYSIYEVQALE-RKELIKNRAICAMSLAELQE 585
+KKL ++ + + Q++L + E++A E K+L + I + + +LQ+
Sbjct: 731 QIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQK 790
Query: 586 PLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSKTMIFYAKINELNE----ELKAKE 641
LE +++ ++E + K +D E +T I + ++N + EL+ +
Sbjct: 791 KSEALESIKQKLTKQEEEKQILK-----QDFETLSQETKIQHEELNNRIQTTVTELQKVK 845
Query: 642 EEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKK----DCEERIFEEDQRFRVLL 697
EK++ L +K+K + +++++ F+ Q+ K D E+ E + +V +
Sbjct: 846 MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQM 905
Query: 698 AVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKK 757
K ++ +K + E + +L E +Q ++ ++ ++ L +I + K
Sbjct: 906 ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK 965
Query: 758 QLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAVQEESSNLMQH 812
Q + +++ Q K+ VL Q ++ Q++ A +E+ S L +
Sbjct: 966 QSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
Score = 64.3 bits (155), Expect = 4e-10
Identities = 108/556 (19%), Positives = 240/556 (43%), Gaps = 77/556 (13%)
Query: 100 ISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPEL 159
+S ++D SK+ + LK ++ FE+ ++ L + KE+K +L
Sbjct: 855 LSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAIL----DLEKTCKELK---------HQL 901
Query: 160 KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQK 219
+ +ME L E L KSLE ++ +A LK + + +M I + + K E K
Sbjct: 902 QVQMENTLKEQKELKKSLEKEK-EASHQLKLELN--SMQEQLIQAQNTLKQNE------K 952
Query: 220 EHEAYLSDVIELQWHLEDKANQLQHFE-------KQKTELEEANAKIQADIDYMNEHGPL 272
E + ++ EL+ E K Q++ + QKTELE K+Q + +
Sbjct: 953 EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN---KLQQQLTQAAQE--- 1006
Query: 273 LDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQ 332
+ + +++ L+N+Y+K E ++L+ E+ L +Q + +++ +
Sbjct: 1007 -LAAEKEKISVLQNNYEKSQETF-------KQLQSDFYGRESELLATRQDLKSVEEKLSL 1058
Query: 333 DEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEA------IRETKSSK--- 383
++ + + + +I N L ++ + + +KE+++ E I++ KS K
Sbjct: 1059 AQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKE 1118
Query: 384 --NELHSLSKMLEDLRRVYDQLT---WKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKD 438
NE L+++ E R ++T + KSH+ + ++ + + AK+ + ++
Sbjct: 1119 LVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGK 1178
Query: 439 FSAISLACTKLTEDNKKLEIDINKITVK-TNESIRKKSKYESEIKYLTIMKLKNDKHLKN 497
++ A + + + L+ + K + E I K++K SEIK + K++++
Sbjct: 1179 ADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAK 1238
Query: 498 IYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYS 557
+ + + K + + +++E+ ++ +GE+A VL+ + +
Sbjct: 1239 LTMQITALNENLGTVKKEWQSSQRRVSELEKQTDD--------LRGEIA---VLEATVQN 1287
Query: 558 IYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLE 617
+ ER+ L++ + +LQ +L+L+ + + + +E +S K +
Sbjct: 1288 NQD----ERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQ 1343
Query: 618 ATKSKTMIFYAKINEL 633
A K +A+ NE+
Sbjct: 1344 ALNRK----WAEDNEV 1355
Score = 45.1 bits (105), Expect = 3e-04
Identities = 58/288 (20%), Positives = 126/288 (43%), Gaps = 31/288 (10%)
Query: 107 ESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETL 166
E ++QE K + +E ++ K+L + S ++E+K +++++ +L +E+++
Sbjct: 1095 EQQLQERCKALQDIQKE--KSLKEKELVNEKSKLAEIEEIKC--RQEKEITKLNEELKSH 1150
Query: 167 LSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQE------LPLAVQKE 220
E+I+ I +L+ DA++ L QQ+ + K DS QE L V+KE
Sbjct: 1151 KLESIKEITNLK----DAKQLLIQQKLE---LQGKADSLKAAVEQEKRNQQILKDQVKKE 1203
Query: 221 HEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQE 280
E + IE + L ++++ E + EE AK+ I +NE+
Sbjct: 1204 EEELKKEFIEKEAKLH---SEIKEKEVGMKKHEENEAKLTMQITALNEN----------- 1249
Query: 281 LQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAY 340
L +K ++ + K ++L + E Q + + + + E IE
Sbjct: 1250 LGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKL 1309
Query: 341 KREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHS 388
+ ++ +L D+ +++V + + + + T+A+ + NE+ +
Sbjct: 1310 QTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQN 1357
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 84.7 bits (208), Expect = 3e-16
Identities = 151/672 (22%), Positives = 281/672 (41%), Gaps = 120/672 (17%)
Query: 144 KEVKPGEKRDEKCPELKQEMETLLSEA---IRLIKSLETDRADAEEALKQQRSRK----- 195
K+++ E+ ++ ++ +E E LL + +KS T + L +Q K
Sbjct: 1552 KDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELH 1611
Query: 196 ----NMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIE--------LQWHLEDKANQLQ 243
+M+ K D +L E + + H + ++E L + ++ QL
Sbjct: 1612 LLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLT 1671
Query: 244 HFEKQKTELEEANAKIQADIDYMNEHGP----LLDSKQ--NQELQDLKNHYKKKMEVMDL 297
KQ+ E EE N +Q + M++H +LD Q N ELQ LK + ++ V +L
Sbjct: 1672 LI-KQEIEKEEEN--LQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQR--VSEL 1726
Query: 298 HRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSS 357
+ LEE LE EN + +QQ K EI+ ++ +E KREI ++ +
Sbjct: 1727 EKTQVAVLEEKLEL-ENLQQISQQQKGEIE----WQKQLLERDKREIERMTA-------- 1773
Query: 358 VINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEA 417
E+++ ++ + LSK EDL+ D W++K + + + A
Sbjct: 1774 --------------------ESRALQSCVECLSKEKEDLQEKCD--IWEKKLAQTKRVLA 1811
Query: 418 VNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKY 477
AA++ +E S++ K + L KL ++ +L D K+++ + S ++
Sbjct: 1812 -----AAEENSKMEQSNLEK----LELNVRKLQQELDQLNRD--KLSLHNDISAMQQQLQ 1860
Query: 478 ESEIKYLTIMK-LKNDKHLKNIYKEAYRIGTLFHLTKHKT------DEMEDKIAEVRRKF 530
E ++ + L N + N+ K+ L H TKH+ ++ I+E +F
Sbjct: 1861 EKREAVNSLQEELANVQDHLNLAKQ-----DLLHTTKHQDVLLSEQTRLQKDISEWANRF 1915
Query: 531 KG-REEFLKKLTQGEVAAGMVLQKKLYSIYEVQALER--KELIKNRAICAMSLAELQEPL 587
+ ++E K Q +V + + KL + + +R KE + S L+E
Sbjct: 1916 EDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQ 1975
Query: 588 LQLEDEA------------------ERIRSLDKEHSVSKRSAIFKDLEATKSKTMIFYAK 629
QLE E ER+R+L +E + ++ K L TK + +
Sbjct: 1976 HQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCE--SLEKTLSQTKRQLSEREQQ 2033
Query: 630 INELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQ-EKKDCEERIFE 688
+ E + EL A ++E S +L+N+F+T R K E ++ ++ E+ + E
Sbjct: 2034 LVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLE 2093
Query: 689 EDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYD---K 745
+ Q + QK + + + D+ E RL +E Q+Q + + K N D +
Sbjct: 2094 QKQENSCI----QKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERR 2149
Query: 746 QLSLDTSIRDKK 757
Q+ + ++R K
Sbjct: 2150 QMEISDAMRTLK 2161
Score = 65.1 bits (157), Expect = 3e-10
Identities = 118/583 (20%), Positives = 239/583 (40%), Gaps = 65/583 (11%)
Query: 222 EAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQEL 281
E +S + ++ HL+ K + + K + E+ ++ +ID + + L+ E+
Sbjct: 1322 ENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLEC----EV 1377
Query: 282 QDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYK 341
++L +K+ + D E L LE K+ + E+I +I EKT+ +
Sbjct: 1378 EELHRTVQKRQQQKDFIDGNVESLMTELEI-----EKSLKHHEDIVDEIECIEKTLLKRR 1432
Query: 342 REIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLED----LR 397
E+ + + L S + + E+ T+A R ++++ L + ++ L
Sbjct: 1433 SELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLV 1492
Query: 398 RVYDQLTWKQ---------KSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTK 448
+ QL Q K + + L+ +N AAK + DF +S K
Sbjct: 1493 KADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDS----------DFQCLSKKKEK 1542
Query: 449 LTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTL 508
LTE+ +KL+ DI + NE + ESE+ L + + +K + + + L
Sbjct: 1543 LTEELQKLQKDIE--MAERNEDHHLQVLKESEV-LLQAKRAELEKLKSQVTSQQQEMAVL 1599
Query: 509 FHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKE 568
HK +E+ + + + + + L GE + +K I EV++L +E
Sbjct: 1600 DRQLGHKKEELHLLQGSM---VQAKADLQEALRLGETE----VTEKCNHIREVKSL-LEE 1651
Query: 569 LIKNRAICAMSLAELQEPLLQLEDEAER--------IRSLDKEHSVSKRSAIFKDLEATK 620
L + + ++E + L ++ E E+ +R + K + K LE +
Sbjct: 1652 LSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHE 1711
Query: 621 SKTM----------IFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQT 670
+ + + ++ L E+L+ + ++ S Q EI K + R KRE +
Sbjct: 1712 LQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERM 1771
Query: 671 VFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQ-EYQQLQ 729
+ + + C E + +E + + + +K L T++++A + EEN ++ Q ++L+
Sbjct: 1772 TAE--SRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLA-AAEENSKMEQSNLEKLE 1828
Query: 730 ITFLKEKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQE 772
+ K + + +LSL I +Q Q +R QE
Sbjct: 1829 LNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQE 1871
Score = 50.1 bits (118), Expect = 9e-06
Identities = 115/580 (19%), Positives = 222/580 (38%), Gaps = 102/580 (17%)
Query: 206 SVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDY 265
S+ L+ P+ Q EA+ ++ LE+ + EK+ E EE +K ++
Sbjct: 246 SLESLEGQPVTTQDRQEAFE------RFSLEEVERLERDLEKKMIETEELKSKQTRFLEE 299
Query: 266 MNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQI--- 322
+ L S + + + ++ + K ++ + + ++ E AC+ Q++
Sbjct: 300 IKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFY 359
Query: 323 -------------KEEIDKDIYQDEKTI---EAYKREIYQLNSLFDHYSSSVINVNTNIE 366
E + D DE YKR ++ S +I+ ++
Sbjct: 360 KIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESY-------IIDSAQAVQ 412
Query: 367 EKEEEVTEAIRETKSSKNELHSLSKMLED-----------LRRVYDQLTWKQKSHENQYL 415
K+ E E +R + L LED L ++D++ + E Q L
Sbjct: 413 IKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEI----EKAEQQIL 468
Query: 416 EAVNDFYAAKKTWDI-ELSDVAKDFSAISLA-----CTKLTEDNKKLEIDINKITVKTNE 469
A +F ++ + ++S+ KD L+ KL ++ LE+ + K +
Sbjct: 469 RATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQME----KQKQ 524
Query: 470 SIRKKSKYESEIKYLTI-MKLKNDKHLKNIYKEAYRIG---------TLFHLTKHKTDEM 519
I K K EIK L I + + K K+ + +A + G + + + DE+
Sbjct: 525 EIAGKQK---EIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEI 581
Query: 520 EDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMS 579
+IA+ + K EE +LT+G++AA L+K L + E IK +A A +
Sbjct: 582 LSRIAKETEEIKDLEE---QLTEGQIAANEALKKDLEGVIS-GLQEYLGTIKGQATQAQN 637
Query: 580 ----LAELQEPLLQLEDEAERIRS----------------LDKEHSVSKRSAIFKDLEAT 619
L + +E LLQ E E+ R + E ++ ++ + L+ T
Sbjct: 638 ECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQT 697
Query: 620 KSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEK 679
+ + A EL L ++ E + LE + + ++ Q + Q
Sbjct: 698 QGDLSAYEA---ELEARLNLRDAEANQLKEELEKVTR---LTQLEQSALQAELEKERQAL 751
Query: 680 KDC--EERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEE 717
K+ + + EE ++ L + K LQD ++ L++
Sbjct: 752 KNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKD 791
Score = 48.5 bits (114), Expect = 2e-05
Identities = 143/713 (20%), Positives = 286/713 (40%), Gaps = 125/713 (17%)
Query: 107 ESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGE--KRDEKCPELKQEME 164
+ K+ + LK E + S ++LK D + + + K E + +K EL+QE+
Sbjct: 303 QDKLNKSLKE-----EAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELA 357
Query: 165 TLLSEA----IRLIKS--LETDRA-DAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAV 217
+A + S E D+A D + + R ++NM +S+ + Q + +
Sbjct: 358 FYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMF--ATESYIIDSAQAVQIKK 415
Query: 218 QKEHEAYLSDVIELQWH------LEDKANQLQ---------HFEKQKTE----------- 251
+ E +D + L+ H LEDK ++ H E +K E
Sbjct: 416 MEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFK 475
Query: 252 -LEEAN-----AKIQADIDYMNEHGPL-LDSKQNQELQDLKNHYKKKMEVMDLHRKVNEE 304
LEEA ++ D+ Y G L L +K QE DL+ +K+ + + +K ++
Sbjct: 476 QLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKD 535
Query: 305 LEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTN 364
L+ A+++ ++ K +K + E+ ++ ++ QL S D S +
Sbjct: 536 LQIAIDSLDSKDPKHSHMKAQKSGK----EQQLDIMNKQYQQLESRLDEILSRIAKETEE 591
Query: 365 IEEKEEEVTEA-IRETKSSKNELHS-LSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFY 422
I++ EE++TE I ++ K +L +S + E L + Q T Q +E + L +
Sbjct: 592 IKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQAT--QAQNECRKLRDEKETL 649
Query: 423 AAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDI---NKITVKTNESIRKKSKYES 479
+ T E+ +++ + ++ +LE + +++ ++ S YE+
Sbjct: 650 LQRLT---EVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEA 706
Query: 480 EIKYLTIMKLKNDKHLKNIYKEAYRIGTL------FHLTKHK------------TDEMED 521
E++ ++ LK ++ R+ L L K + ++E E
Sbjct: 707 ELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQ 766
Query: 522 KIAEVRRKFKGREEFLKKLTQ---------GEVAAGMVLQKKLYSIYEVQALERK----- 567
+ +E+ K K ++ L Q V G+V +++ + V L RK
Sbjct: 767 ENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAA--RVDELRRKLKLGT 824
Query: 568 ---ELIKNRAICAMSLAELQEPLLQL-------EDEAE-RIRSLDKEHSVSKRSAIFKDL 616
+ + SLA+LQ+ ++ DEA+ R R L +E ++ +
Sbjct: 825 GEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQE 884
Query: 617 EATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYM 676
E ++ A+ +N + + E + + + L+ +M E Q + D +
Sbjct: 885 EFRQACERALEAR---MNFDKRQHEARIQQMENEIHYLQENLKSM----EEIQGLTDLQL 937
Query: 677 QEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQ 729
QE + +ERI + + ++K L+D A S E+ L +E ++L+
Sbjct: 938 QEADEEKERILAQLRELE-----KKKKLED-----AKSQEQVFGLDKELKKLK 980
Score = 41.2 bits (95), Expect = 0.004
Identities = 83/431 (19%), Positives = 163/431 (37%), Gaps = 53/431 (12%)
Query: 3 ENKTVSSSSTRDDQTNIGLTCQEVKALREKAWSRTNEGNAMSQSLVLYGASKENSEGFHE 62
EN + S+ + N+ QE+ L S N+ +AM Q L K + +
Sbjct: 1815 ENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQL----QEKREAVNSLQ 1870
Query: 63 SKMTNTEGVNKGIYFSYPCRRHSCAVVNIPAPCVNKMISHIQDV----ESKIQEHLKRFE 118
++ N + +N+ + H QDV ++++Q+ + +
Sbjct: 1871 EELANVQD-----------------HLNLAKQDLLHTTKH-QDVLLSEQTRLQKDISEWA 1912
Query: 119 TSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEM--ETLLSEAIRLIKS 176
FE+ + TK + +V E + K ++QEM + L E
Sbjct: 1913 NRFEDCQKEEETKQQQ---------LQVLQNEIEENKLKLVQQEMMFQRLQKERESEESK 1963
Query: 177 LETDRADAEEALKQQRSRKNMINMKIDS--WSVWKLQELPLAVQKEHEAYLSDVIELQWH 234
LET + +E Q K+D V +E +Q+E S L+
Sbjct: 1964 LETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCES----LEKT 2019
Query: 235 LEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEV 294
L QL E+Q E +Q + D M LL +NQ L + K K+ +
Sbjct: 2020 LSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLL---RNQFLTERKKAEKQVASL 2076
Query: 295 MDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHY 354
+ + +LE+ L + Q+ I+ + + +E+ Q+ +
Sbjct: 2077 KEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTEL 2136
Query: 355 SSSVINVNTNIEEKEEEVTEAIRETKSS-----KNELHSLSKMLEDLRRVYDQLTWKQKS 409
+ N ++E ++ E+++A+R KS + L +L++ L +L + + + ++
Sbjct: 2137 KKQMAN-QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNEN 2195
Query: 410 HENQYLEAVND 420
E + LE++ +
Sbjct: 2196 LEGE-LESLKE 2205
Score = 35.0 bits (79), Expect = 0.29
Identities = 84/445 (18%), Positives = 179/445 (40%), Gaps = 66/445 (14%)
Query: 385 ELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISL 444
E H+L + L + L K K E +++ A +K+ + E+ ++ +
Sbjct: 1317 EHHNLENEVSRLEDIMQHL--KSKKREERWMRA------SKRQSEKEMEELHHNID---- 1364
Query: 445 ACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYL-TIMKL-KNDKHLKNIYKEA 502
L ++ K LE ++ ++ + ++K + ++ L T +++ K+ KH ++I E
Sbjct: 1365 ---DLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEI 1421
Query: 503 YRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQ 562
I + + E + +AE + +E K + A L L + + +
Sbjct: 1422 ECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSL---LQTESDAE 1478
Query: 563 ALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSK 622
LER+ QE + L +++RSL + KDLE K K
Sbjct: 1479 ELERRA---------------QETAVNLVKADQQLRSLQADA---------KDLEQHKIK 1514
Query: 623 TMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDC 682
+ E+N+ + AK+ + + + E L + ++ E A+ DH++Q K+
Sbjct: 1515 QEEI---LKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKES 1571
Query: 683 EERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNI 742
E + + +R + Q T Q + + D + + +E LQ + ++ K
Sbjct: 1572 E--VLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKK--EELHLLQGSMVQAK------ 1621
Query: 743 YDKQLSLDTSIRDKKQLCQLQRRMHTLWQE--------HFKLVVLFSQMRLANFQTD-SQ 793
D Q +L + + C R + +L +E + ++ +Q+ L + + +
Sbjct: 1622 ADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEE 1681
Query: 794 ESIQKILAVQEESSNLMQHILGFFQ 818
E++Q +L + +++IL Q
Sbjct: 1682 ENLQVVLRQMSKHKTELKNILDMLQ 1706
Score = 30.4 bits (67), Expect = 7.0
Identities = 65/315 (20%), Positives = 122/315 (38%), Gaps = 56/315 (17%)
Query: 451 EDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFH 510
E+ ++LE D+ K ++T E K++++ EIK DK K++ +EA
Sbjct: 270 EEVERLERDLEKKMIETEELKSKQTRFLEEIK-------NQDKLNKSLKEEAM------- 315
Query: 511 LTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELI 570
L K +E++ + + E LK+ T + L + YE++
Sbjct: 316 LQKQSCEELKSDL-------NTKNELLKQKT-------IELTRACQKQYELE-------- 353
Query: 571 KNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKS----KTMIF 626
+ + + EPL E I E +S +++ AT+S
Sbjct: 354 --QELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAV 411
Query: 627 YAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERI 686
K E +E+L+ + L++K K AQT E + E++I
Sbjct: 412 QIKKMEPDEQLRNDHMNLRGHTPLDTQLEDK----EKKISAAQTRLSELHDEIEKAEQQI 467
Query: 687 FEEDQRFRVL-LAVRQKTLQDT-----QKIIADSLEENLRLAQEYQQLQITFLKEKDNYF 740
+ F+ L A++ K + + K ++ L+ +L QE L++ K+K
Sbjct: 468 LRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIA 527
Query: 741 ----NIYDKQLSLDT 751
I D Q+++D+
Sbjct: 528 GKQKEIKDLQIAIDS 542
>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
sapiens]
Length = 709
Score = 84.0 bits (206), Expect = 5e-16
Identities = 147/662 (22%), Positives = 281/662 (42%), Gaps = 79/662 (11%)
Query: 186 EALKQQRSRKNMINMKIDSWSVWKLQELPLAVQK------EHEAYLSDVIELQWHLEDKA 239
+ KQQ+ K +N+ D+ +++ + K E A + +L+ LE
Sbjct: 42 QRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKME 101
Query: 240 NQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQ------------ELQDLKNH 287
+L ++KT L NA ++ + + LL SK ++ EL L+N
Sbjct: 102 ARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNK 161
Query: 288 YKKKMEVMDLHRKVNE-ELEEALEACENARLKAQQI--------KEEIDKDIYQDEKTIE 338
+ KM M ++ E +L+ + E ++ K Q+ KE+ID+ + EK +E
Sbjct: 162 RETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS-ETEKLLE 220
Query: 339 AYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRR 398
Y EI + + Y + + N++EK +E+ +S + + LSK +EDL
Sbjct: 221 -YIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSL---KQSLEENIVILSKQVEDLNV 276
Query: 399 VYDQLTWKQKSHENQYLEAVNDFYAA----KKTWDIELSDVAKDFSAISLACTKLTEDNK 454
L +++ H N+ E + A K+ + +E + K L L + K
Sbjct: 277 KCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREK-LQQKELQIDSLLQQEK 335
Query: 455 KLEIDIN-KITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTK 513
+L ++ K+ E +++K+ +E E+K T+ +L DK L+ ++A R L K
Sbjct: 336 ELSSSLHQKLCSFQEEMVKEKNLFEEELKQ-TLDEL--DK-LQQKEEQAER------LVK 385
Query: 514 HKTDEMEDKIAEVR---RKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALE--RKE 568
+E + + E++ K KG+E L+K + A ++LQ+K S+ VQ+LE +
Sbjct: 386 QLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM--VQSLEDVTAQ 443
Query: 569 LIKNRAICAMSLAELQEPLLQLEDEAERI--RSLDKEHSVSKRSAIFKDLEATKSKTMIF 626
+A+ A + +L+ L+++A + + D +H + AT+S +
Sbjct: 444 FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQIL----------ATESSNQEY 493
Query: 627 YAKINELNEELKAKEEEKK----SFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDC 682
+ +L + KE E K SF Q + L+N+ + EK++
Sbjct: 494 VRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENT 553
Query: 683 EERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNI 742
+ EE ++R+L + Q + E L E+ Q K +D+Y +
Sbjct: 554 TAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKL 613
Query: 743 YDKQLSLDTSIRDK-KQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILA 801
Q +++ K K + +L+ L E KL ++ + + +T QE + K+L
Sbjct: 614 LGHQ-----NLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQS--ETKLQEELNKVLG 666
Query: 802 VQ 803
++
Sbjct: 667 IK 668
Score = 51.6 bits (122), Expect = 3e-06
Identities = 82/459 (17%), Positives = 187/459 (40%), Gaps = 77/459 (16%)
Query: 103 IQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSV----TTPVKEVKPGEKRDEK--- 155
IQD+E+++++ R + E + S+ E + T + + K E ++K
Sbjct: 90 IQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLR 149
Query: 156 -----CPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSR------------KNMI 198
+L+ + ET + + + +E + +L++ + + K I
Sbjct: 150 ILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKI 209
Query: 199 NMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAK 258
+ K ++ + + E + E Y D+ +L+ +L++K +++ K LEE
Sbjct: 210 DEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSL---KQSLEENIVI 266
Query: 259 IQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLK 318
+ ++ +N LL+ K+K + ++ +R+ NE L ++ + +
Sbjct: 267 LSKQVEDLNVKCQLLE--------------KEKEDHVNRNREHNENLNAEMQNLKQKFIL 312
Query: 319 AQQIKEEIDK------DIYQDEKTIE--------AYKREIYQLNSLFDHYSSSVINVNTN 364
QQ +E++ + + Q EK + +++ E+ + +LF+ ++
Sbjct: 313 EQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 372
Query: 365 IEEKEEEVTEAIR----ETKSSKNELHSLSKM-------LEDLRRVYDQLTWKQKSHENQ 413
+++KEE+ ++ E KS EL L + LE + Q T + +
Sbjct: 373 LQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDS 432
Query: 414 YLEAVND----FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNE 469
++++ D F + K E+ D+ + S++ K ++ + ++ I E
Sbjct: 433 MVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQE 492
Query: 470 SIR-------KKSKYESEIKYLTIMKLKNDKHLKNIYKE 501
+R K + E+EIK +T+ L+ L+N K+
Sbjct: 493 YVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQ 531
Score = 45.4 bits (106), Expect = 2e-04
Identities = 97/491 (19%), Positives = 182/491 (37%), Gaps = 127/491 (25%)
Query: 333 DEKTIEAYKREI-YQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSL-- 389
D KT+E K + +Q + F S N+N +K+ + + R+ KSS++++ L
Sbjct: 25 DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNV---DKDTTLPASARKVKSSESKIRVLLQ 81
Query: 390 SKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKL 449
+ +D RR+ D T EL + +A T L
Sbjct: 82 ERGAQD-RRIQDLET--------------------------ELEKMEARLNAALREKTSL 114
Query: 450 TEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLF 509
+ +N LE + ++T +TNE ++ K K L I+ L+ K L+N
Sbjct: 115 SANNATLEKQLIELT-RTNELLKSKFSENGNQKNLRILSLELMK-LRN------------ 160
Query: 510 HLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKEL 569
+ E K+ + K +G E M LQ S+ E Q
Sbjct: 161 --------KRETKMRGMMAKQEGME--------------MKLQVTQRSLEESQG------ 192
Query: 570 IKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSKTMIFYAK 629
+A+L+ L+ +E E +D++ K +++ + +
Sbjct: 193 ---------KIAQLEGKLVSIEKE-----KIDEKSETEKLLEYIEEISCASDQVEKYKLD 238
Query: 630 INELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEE 689
I +L E LK K +E S Q+LE + + + E +EK+D R
Sbjct: 239 IAQLEENLKEKNDEILSLKQSLE---ENIVILSKQVEDLNVKCQLLEKEKEDHVNR---- 291
Query: 690 DQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSL 749
+ E N L E Q L+ F+ E+ + K+L +
Sbjct: 292 ------------------------NREHNENLNAEMQNLKQKFILEQQEREKLQQKELQI 327
Query: 750 DTSIRDKKQL-CQLQRRMHTLWQEHFKLVVLFSQM------RLANFQTDSQESIQKILAV 802
D+ ++ +K+L L +++ + +E K LF + L Q +++ + + +
Sbjct: 328 DSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQL 387
Query: 803 QEESSNLMQHI 813
+EE+ + + +
Sbjct: 388 EEEAKSRAEEL 398
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 83.6 bits (205), Expect = 7e-16
Identities = 146/718 (20%), Positives = 303/718 (42%), Gaps = 104/718 (14%)
Query: 150 EKRDEKCPELKQEMETLLSEAIRLIKSLETDR---ADAEEALKQQRSRKNMINMKIDSWS 206
EK + + ELK + +L E LI L+ ++ A+ EE + K + ++ S
Sbjct: 876 EKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELS 935
Query: 207 --VWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADID 264
V + +E+ + + EL+ ++D L EK+K E + +++
Sbjct: 936 ERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVE 995
Query: 265 YMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKE 324
++NE SK N+ + ++ +++ ++ DLH + EE L + A LK +Q +
Sbjct: 996 FLNED----ISKLNRAAKVVQEAHQQTLD--DLHME-----EEKLSSLSKANLKLEQQVD 1044
Query: 325 EIDKDIYQDEKTIEAYKREIYQL-------NSLFDHYSSSVINVNTNIEEKEEEVTEAIR 377
E++ + Q+ K +RE+++L ++ SS ++ + +KE E+++
Sbjct: 1045 ELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNS 1104
Query: 378 ETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDI-ELSDVA 436
+ ++ K + L K +++L+ L K+K + A + A T D+ +L++
Sbjct: 1105 KVENEKGLVAQLQKTVKELQTQIKDL--KEKLEAERTTRAKMERERADLTQDLADLNERL 1162
Query: 437 KDFSAISLACTKLTEDN----KKLEIDINKITV---KTNESIRKK-----SKYESEIKYL 484
++ SLA ++T+ +KL D+ + T+ T+ S++K+ ++ E +++ L
Sbjct: 1163 EEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENL 1222
Query: 485 TIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGE 544
+K K +K ++ E D++ ++ ++ R K E L L +
Sbjct: 1223 QQVKQKLEKDKSDLQLE--------------VDDLLTRVEQMTRA-KANAEKLCTLYEER 1267
Query: 545 VAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEH 604
+ K+ + A ++ +L +E E L +LE++ I L +E
Sbjct: 1268 LHEATAKLDKVTQLANDLAAQKTKL----------WSESGEFLRRLEEKEALINQLSREK 1317
Query: 605 SVSKRSAIFKDL-----EATKSKTMIFYA------KINELNEELKAKEEEKKSFDQTLEI 653
S R +DL + TKS++ + +A + L E+ + ++E K +TL
Sbjct: 1318 SNFTRQ--IEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSK 1375
Query: 654 LKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIAD 713
+ + + R K E ++ +Q +D E+ E LA+R LQ+ + +
Sbjct: 1376 VNAEMVQWRMKYE------NNVIQRTEDLEDAKKE--------LAIR---LQEAAEAMGV 1418
Query: 714 SLEENLRLAQEYQQLQI-------TFLKEKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRM 766
+ N L + QLQ+ K + + KQL ++ D KQ + + +
Sbjct: 1419 ANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQAL 1478
Query: 767 HTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAVQEESSNLMQHILGFFQTLTDGT 824
Q+ + + L + +ESI ++ E+ NL + I + +GT
Sbjct: 1479 LDASQKEVQAL----STELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGT 1532
Score = 65.9 bits (159), Expect = 2e-10
Identities = 88/516 (17%), Positives = 215/516 (41%), Gaps = 93/516 (18%)
Query: 160 KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMIN-----MKIDSWSVWKLQELP 214
++E++ L +E ++L + E E ++ ++ + I+ ++ + ++ +++++
Sbjct: 1483 QKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVK 1542
Query: 215 LAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLD 274
+++E + E + LE +++ HF+ EL EA A+ L+
Sbjct: 1543 KLIEEEKTEVQVTLEETEGALERNESKILHFQ---LELLEAKAE--------------LE 1585
Query: 275 SKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDE 334
K +++ ++++N +K+ +D L+ +L++ +R++ ++K+++++D+ + E
Sbjct: 1586 RKLSEKDEEIENFRRKQQCTID-------SLQSSLDSEAKSRIEVTRLKKKMEEDLNEME 1638
Query: 335 KTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLE 394
+ R++ + + ++ +++ + ++ + ++ L LE
Sbjct: 1639 LQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELE 1698
Query: 395 DLRRVYDQLTWKQKSHENQYLEA---VNDFYAAKKTWDIELSDVAKDFSAISLACTKLTE 451
DLR + +Q ++ E + LEA +N FY T L
Sbjct: 1699 DLRSLQEQTERGRRLSEEELLEATERINLFYTQN---------------------TSLLS 1737
Query: 452 DNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHL 511
KKLE D+ ++ + E +++ E + K I + LK + T+ HL
Sbjct: 1738 QKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKK------KQDTIAHL 1791
Query: 512 TKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIK 571
+ + + ME I +++ K+L + E A M +K ++Q LE +
Sbjct: 1792 ERTR-ENMEQTITDLQ----------KRLAEAEQMALMGSRK------QIQKLESR---- 1830
Query: 572 NRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSKTMIFYAKIN 631
+ EL+ L E E RS + + + K+L + +++
Sbjct: 1831 --------VRELEGEL-----EGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQ 1877
Query: 632 ELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREH 667
++L+ K + K + E N++++ K++H
Sbjct: 1878 TQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQH 1913
Score = 63.2 bits (152), Expect = 1e-09
Identities = 151/705 (21%), Positives = 285/705 (40%), Gaps = 122/705 (17%)
Query: 151 KRDEKCPELKQEMET---LLSEAIRLIKSLETDRADAEEALKQQRS-RKNMINMKIDSWS 206
K++ + ++ ++E L+++ + +K L+T D +E L+ +R+ R M + D
Sbjct: 1094 KKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQ 1153
Query: 207 VW-----KLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQA 261
+L+E+ + + E + Q D HFE L++ +A A
Sbjct: 1154 DLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLA 1213
Query: 262 DIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQ 321
+++ E+ + K ++ DL+ +EV DL +V + A + L ++
Sbjct: 1214 ELEGQVENLQQVKQKLEKDKSDLQ------LEVDDLLTRVEQMTRAKANAEKLCTLYEER 1267
Query: 322 IKE---EIDKDIYQDEKTIEAYK-----------REIYQLNSLFDHYSSSVINVNTNIEE 367
+ E ++DK + Q + A K R + + +L + S N IE+
Sbjct: 1268 LHEATAKLDK-VTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIED 1326
Query: 368 KEEEVTEAIRETKSSKNELHSLSKMLED---LRRVYDQ-------------------LTW 405
++ +ETKS H+L K D LR Y++ + W
Sbjct: 1327 LRGQLE---KETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQW 1383
Query: 406 KQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEI------- 458
+ K +EN ++ D AKK I L + A+ + L +L++
Sbjct: 1384 RMK-YENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALS 1442
Query: 459 DINKITVKTNESIRK-----------KSKYE----------SEIKYLTIMKLKNDKHLKN 497
D+ K+ +K K K+E E++ L+ LK LKN
Sbjct: 1443 DLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLK----LKN 1498
Query: 498 IYKEAYRIG--TLFHLTKHKTDEMEDKIAEVRRKFKGREEF--LKKLTQGEVAAGMVLQK 553
Y+E+ +G TL K+ +E+ + +VR K E +KKL + E V +
Sbjct: 1499 TYEESI-VGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLE 1557
Query: 554 KLYSIYEVQALERKE--LIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSA 611
+ ALER E ++ + + AEL+ L + ++E E R + S +S+
Sbjct: 1558 ETEG-----ALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSS 1612
Query: 612 IFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTV 671
+ D EA KS+ + K ++ E+L E + ++ + ++ + + Q
Sbjct: 1613 L--DSEA-KSRIEVTRLK-KKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQ 1668
Query: 672 FDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQIT 731
D Q D +E++ ++R +L Q L+D + + + E RL++E + L+ T
Sbjct: 1669 LDDSTQLNSDLKEQVAVAERRNSLL----QSELEDLRS-LQEQTERGRRLSEE-ELLEAT 1722
Query: 732 FLKEKDNYFNIYDKQLSLDTSIRDKKQL----CQLQRRMHTLWQE 772
E+ N F Y + SL + KK+L ++Q+ + QE
Sbjct: 1723 ---ERINLF--YTQNTSL---LSQKKKLEADVARMQKEAEEVVQE 1759
Score = 53.1 bits (126), Expect = 1e-06
Identities = 90/507 (17%), Positives = 205/507 (40%), Gaps = 50/507 (9%)
Query: 304 ELEEALEACENAR--LKAQQI-----KEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSS 356
+L++ALE E R LKA+Q+ K ++ + +++T+ + + L +
Sbjct: 870 QLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEA 929
Query: 357 SVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLE 416
V ++ +EE+EE +E + ++E L K ++DL + + ++++ E++
Sbjct: 930 RVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKV-- 987
Query: 417 AVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSK 476
K E+ + +D S ++ A + E +++ D++ K + + K
Sbjct: 988 ---------KNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLK 1038
Query: 477 YESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEF 536
E ++ L + K N +E +++ L + + +E + + + +E
Sbjct: 1039 LEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELE 1098
Query: 537 LKKL-TQGEVAAGMVLQ------------KKLYSIYEVQALERKELIKNRAICAMSLAEL 583
L ++ ++ E G+V Q K L E + R ++ + RA LA+L
Sbjct: 1099 LSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADL 1158
Query: 584 QE--------PLLQLEDEAERIRSLDKEHSVSKRSAI-FKDLEATKSKTMI-----FYAK 629
E L QLE ++ K H + + + F+ A+ K +
Sbjct: 1159 NERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQ 1218
Query: 630 INELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEE 689
+ L + + E++K ++ L + M + +A+ + Y + + ++ +
Sbjct: 1219 VENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKV 1278
Query: 690 DQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDK---- 745
Q L A + K ++ + + LEE L + + + F ++ ++ +K
Sbjct: 1279 TQLANDLAAQKTKLWSESGEFLR-RLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKS 1337
Query: 746 QLSLDTSIRDKKQLCQLQRRMHTLWQE 772
Q +L +++ ++ C L R + QE
Sbjct: 1338 QSALAHALQKAQRDCDLLREQYEEEQE 1364
Score = 46.6 bits (109), Expect = 9e-05
Identities = 60/314 (19%), Positives = 136/314 (43%), Gaps = 41/314 (13%)
Query: 95 CVNKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVT--------TPVKEV 146
C N+ +S ++Q +K + ++ ++ +S DLKE +V + ++++
Sbjct: 1643 CANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNS--DLKEQVAVAERRNSLLQSELEDL 1700
Query: 147 KPGEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWS 206
+ +++ E+ L +E +E I L + T ++ L+ +R M+ ++
Sbjct: 1701 RSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVAR-----MQKEAEE 1755
Query: 207 VWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYM 266
V +QE A +K +A + + L L+ K + + H E+ + +E+ +Q +
Sbjct: 1756 V--VQECQNAEEKAKKAAI-EAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEA 1812
Query: 267 NEHGPLLDSKQNQELQ--------DLKNHYKKKMEVMD----LHRKVNEELEEALEACEN 314
+ + KQ Q+L+ +L+ ++ E L R + E +A E +N
Sbjct: 1813 EQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKN 1872
Query: 315 A----------RLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTN 364
+LK Q K++++ Q + + YK++ ++LN + + + VN
Sbjct: 1873 LSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVN-K 1931
Query: 365 IEEKEEEVTEAIRE 378
++ K E + ++E
Sbjct: 1932 LKIKAREFGKKVQE 1945
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 83.2 bits (204), Expect = 9e-16
Identities = 146/745 (19%), Positives = 318/745 (42%), Gaps = 81/745 (10%)
Query: 109 KIQEHLKRFETSFEEWSRTSSTKDLKEDWSV-TTPVKEVKPGEKRDEKCPELKQEMETL- 166
K + + E F+++ + T ED ++ + + K G +D K E+ TL
Sbjct: 272 KTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLI 331
Query: 167 --LSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAY 224
L E +L+ +++ D A ++ KQ +++ M + + + ++++ ++KEH +
Sbjct: 332 HQLQEKDKLLAAVKEDAAATKDRCKQL-TQEMMTEKERSNVVITRMKDRIGTLEKEHNVF 390
Query: 225 LSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADI--DYMNEHGPLLDSKQNQELQ 282
+ + + + Q +Q E E A+ K + I D ++ L+SKQ+ EL
Sbjct: 391 QNKIHVSYQETQQMQMKFQQVREQM-EAEIAHLKQENGILRDAVSNTTNQLESKQSAELN 449
Query: 283 DLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKR 342
L+ Y + V +L K + +E ++ +NA A Q+K ++ + + E+ ++
Sbjct: 450 KLRQDYARL--VNELTEKTGKLQQEEVQK-KNAEQAATQLKVQLQEAERRWEEVQSYIRK 506
Query: 343 EIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQ 402
+ + S + ++ ++T+ + + + L L M + +RV
Sbjct: 507 RTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQL--MESEQKRVN-- 562
Query: 403 LTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINK 462
K++S + Q + + A K S +A SA LA E+ K+ + +K
Sbjct: 563 ---KEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLA-----EELHKVIAEKDK 614
Query: 463 ITVKTNESIRKK----SKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDE 518
+T +S+ + + E E+K + M LK ++ + H+ ++
Sbjct: 615 QIKQTEDSLASERDRLTSKEEELKDIQNMNFL----LKAEVQKLQALANEQAAAAHELEK 670
Query: 519 MEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIY-EVQALE-------RKELI 570
M+ + K + EE L+ ++ +L + ++ EVQ L+ K+++
Sbjct: 671 MQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVV 730
Query: 571 KNRAICAMSLAE--------LQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSK 622
+ C E L+ L+Q+ + E + ++ E+S + +DL+A ++
Sbjct: 731 EQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV--QDLKAKQND 788
Query: 623 TMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDC 682
+ F + + EL + + K+ + KS + E+L+ + + + K + Q +QE ++
Sbjct: 789 QVSFASLVEELKKVIHEKDGKIKSVE---ELLEAELLKVANKEKTVQLSITSKVQELQNL 845
Query: 683 EERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRL-----------------AQEY 725
+ E+ + +L ++K L +T K + D EEN L A ++
Sbjct: 846 LKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQF 905
Query: 726 QQLQITFLKEKDNYFNIYDKQL-SLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMR 784
++L+I LKEK+N + L ++ + K QL Q + + L++ + Q++
Sbjct: 906 EELEIV-LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE------QLK 958
Query: 785 LANFQTDS----QESIQKILAVQEE 805
N+Q S E + K+++ +E+
Sbjct: 959 QQNYQQASSFPPHEELLKVISEREK 983
Score = 71.2 bits (173), Expect = 4e-12
Identities = 160/854 (18%), Positives = 353/854 (41%), Gaps = 97/854 (11%)
Query: 3 ENKTVSSSSTRDDQTNIGLTCQEVKALREKAWS----RTNEGNAMSQSLVLYGASKENSE 58
+ + V + T + + QE + E+ S RT E A Q L +KEN
Sbjct: 470 QQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEV 529
Query: 59 GFHESKMTNTEGVNKGIYFSYPCRRHSCAVVNIPAPCVNKMIS---HIQDVESKIQEHLK 115
SK+T+T + + ++ VNK S +QD+ + +
Sbjct: 530 QSLHSKLTDT------LVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKA 583
Query: 116 RFETSFEEWSRTSSTKDLKEDWS--VTTPVKEVKPGE-----KRD---EKCPELK--QEM 163
+ + + + +S L E+ + K++K E +RD K ELK Q M
Sbjct: 584 QIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNM 643
Query: 164 ETLLSEAIRLIKSLETDRADAEEAL-KQQRS------RKNMINMKIDSWSVWKLQELPLA 216
LL ++ +++L ++A A L K Q+S + ++ ++ K++E +
Sbjct: 644 NFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKI- 702
Query: 217 VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSK 276
+ +++A S+V +LQ + ++ N+ E+ + ++E + K++ ++ + E G + +
Sbjct: 703 LNDQNKALKSEVQKLQTLVSEQPNK-DVVEQMEKCIQEKDEKLKT-VEELLETGLIQVAT 760
Query: 277 QNQELQDLKNHYKK-KMEVMDLHRKVNEE------LEEALEACENARLKAQQIKEEIDKD 329
+ +EL ++ EV DL K N++ +EE + K + ++E ++ +
Sbjct: 761 KEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAE 820
Query: 330 IYQ---DEKTIE-AYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNE 385
+ + EKT++ + ++ +L +L + + +EEKE+++ + + + E
Sbjct: 821 LLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEE 880
Query: 386 LHSLSKMLEDLRRVYDQLTWKQKSHENQYLE---AVNDFYAAKKTWDIELSDVAKDFSAI 442
SL ++++ Q K+ S +Q+ E + + K + L + D S+
Sbjct: 881 NESLKAHVQEVA----QHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSK 936
Query: 443 SLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEA 502
+ + ++NK + I ++ + + +E +K ++ + +K + ++ E
Sbjct: 937 TQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVIS----EREKEISGLWNEL 992
Query: 503 YRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLK-------KLTQGEVAA----GMVL 551
+ + K +++ +K E E+ L+ K Q +V A +
Sbjct: 993 DSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEV 1052
Query: 552 QKKLYSIYEV----------QALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLD 601
KKL+ V E+K ++ E L+ DE + L+
Sbjct: 1053 LKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLE 1112
Query: 602 KE---HSVSKRSAIFKDLE-ATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILK-- 655
E +++ I + L+ + + + + K++E ++ +K + S +Q LE L+
Sbjct: 1113 CEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSE 1172
Query: 656 NKFI-TMRFKREHAQTVFDH-------YMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDT 707
NK I +R +REH + + Y+ E ++ + ++ E + R RQK D
Sbjct: 1173 NKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDL 1232
Query: 708 QKIIADSLE----ENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKKQLCQLQ 763
K SLE + ++ A + ++ + + + +SL+ ++ +QL Q
Sbjct: 1233 HK-AQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAV 1291
Query: 764 RRMHTLWQEHFKLV 777
+ T +EH++++
Sbjct: 1292 NQQLTKEKEHYQVL 1305
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 83.2 bits (204), Expect = 9e-16
Identities = 150/770 (19%), Positives = 338/770 (43%), Gaps = 106/770 (13%)
Query: 98 KMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCP 157
+++ ++++V S+ QE + E E+ S+TKD TT + + +EK
Sbjct: 1290 ELLPNVKEV-SETQETMNELELLTEQ----STTKDS------TTLARIEMERLRLNEKFQ 1338
Query: 158 ELKQEMETLLSEA--IRLIK-SLETDRADAEEALKQ--------QRSRKNMINMKIDSWS 206
E ++E+++L E ++ IK +LE +E +++ Q ++ +NMK
Sbjct: 1339 ESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNE 1398
Query: 207 VWKLQELPLAVQKEHEAYLSDVIE---LQWHLEDKANQLQHFEKQKTELEEANAKIQADI 263
K+ + + A L IE L L++ ++++ K+K +L+ +Q++
Sbjct: 1399 TTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSES 1458
Query: 264 DYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIK 323
D + E+ + +K + ++LK + E + ++ L E + + + I
Sbjct: 1459 DQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIN 1518
Query: 324 EEID---KDIYQDE-----KTIEAYKREIYQLNSLFDH----------YSSSVINVNTNI 365
+++ ++IY+ E K I + ++ +L +H S ++ + +
Sbjct: 1519 DKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRL 1578
Query: 366 EEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQK-SHENQY----LEAVND 420
+E +EE+ I+E + K +L + L+ ++ K K S E +Y + AVN+
Sbjct: 1579 QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNE 1638
Query: 421 FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESE 480
+K +IE + + F L + +N I + +I + E +R +K +
Sbjct: 1639 --TQEKMCEIE--HLKEQFETQKLNLENIETEN----IRLTQILHENLEEMRSVTKERDD 1690
Query: 481 IKYL-TIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKK 539
++ + +K++ D+ +N+ + T + E ++++ V K +E + K
Sbjct: 1691 LRSVEETLKVERDQLKENLRE-----------TITRDLEKQEELKIVHMHLKEHQETIDK 1739
Query: 540 LTQGEVAAG----MVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQL----E 591
L +G V+ +QK L + + ++ + I M L E QE + +L
Sbjct: 1740 L-RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVS 1798
Query: 592 DEAERIRSLDK--EHSVSKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSF-D 648
++ +++ ++ K E+S +K ++L+A + + + +NE +++ E+ KK D
Sbjct: 1799 EKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKD 1858
Query: 649 QTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQ 708
Q+L + K + + AQ + ++ + K +ER D RV ++TL+ +
Sbjct: 1859 QSLTLSKLEIENLNL----AQKLHENLEEMKSVMKER----DNLRRV-----EETLKLER 1905
Query: 709 KIIADSLEE----NLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRD-----KKQL 759
+ +SL+E +L + QE + ++ + K+ + +K I D K
Sbjct: 1906 DQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSK 1965
Query: 760 CQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAVQEESSNL 809
+LQ+++ L ++ +L+ + + +++ + + E ++K Q E+ NL
Sbjct: 1966 DELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKK----QFEAQNL 2011
Score = 69.7 bits (169), Expect = 1e-11
Identities = 146/690 (21%), Positives = 283/690 (41%), Gaps = 89/690 (12%)
Query: 160 KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQK 219
K+EME +K E + D EAL+++ + + + + ++ L + +
Sbjct: 521 KEEME---------LKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQ 571
Query: 220 EHEAYLSDVIELQWHLEDKANQLQHF-EKQKTELEEANAKIQADIDYMNEHGPLLDSKQN 278
+ E LS +EL ED+ +LQ + + QK E I+ D+ Y E + D KQ
Sbjct: 572 DLENELSSKVELLREKEDQIKKLQEYIDSQKLE------NIKMDLSYSLES--IEDPKQM 623
Query: 279 QE---------LQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKD 329
++ L + + E ++L K+ +EL + EN ++ Q + E K
Sbjct: 624 KQTLFDAETVALDAKRESAFLRSENLELKEKM-KELATTYKQMEND-IQLYQSQLEAKKK 681
Query: 330 IYQD-EKTIEAYKREIYQLNSLFDHYSSSVINVNTNIE----------EKEEEVTEAIRE 378
+ D EK +++ EI +L SL D + N +E KE E EA+RE
Sbjct: 682 MQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALRE 741
Query: 379 TKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKD 438
+EL SL +E LR+ + KS E + + D S+V
Sbjct: 742 EVILLSELKSLPSEVERLRKEI-----QDKSEELHIITSEKDKL---------FSEVVHK 787
Query: 439 FSAISLACTKL--TEDNKKLEIDINKITVKTNESIRK-KSKYESEIKYLTIMKLKNDKHL 495
S + ++ T+D+ K T + ++ + +E + K + + ++ +
Sbjct: 788 ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEI 847
Query: 496 KNIYKEAYR----IGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVL 551
N+ KEA + +G L +KT E+++K EV+ + E+ ++L + V
Sbjct: 848 VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVE 907
Query: 552 QKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSA 611
++K ++Q + E +K L +LQE L D+ + ++ +
Sbjct: 908 REKTLITEKLQ--QTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQ 965
Query: 612 IFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTV 671
+ LE+ K ++++EE+ +++ +T + + K + + K++
Sbjct: 966 LRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKN 1025
Query: 672 FDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIAD------SLEENLRLAQEY 725
+ KD E I E+ ++ L+ + + Q + +IA+ L+EN+ + E
Sbjct: 1026 TQTLTADVKDNE--IIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIEN 1083
Query: 726 QQLQITFLKEKDNYFNIYDKQLSLDTSIRDK--KQLCQLQRRMHTLWQEHFKLVVLFSQM 783
Q+ ++ L ++ KQ + ++ K+ +L R L + KL Q+
Sbjct: 1084 QE-ELRLLGDE------LKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQL 1136
Query: 784 RLANFQTDSQESIQKILAVQEESSNLMQHI 813
QE Q++L VQEE S + + I
Sbjct: 1137 ---------QEKQQQLLNVQEEMSEMQKKI 1157
Score = 66.6 bits (161), Expect = 9e-11
Identities = 149/734 (20%), Positives = 308/734 (41%), Gaps = 122/734 (16%)
Query: 96 VNKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEK 155
++ M +++ +K+QE ++ + + E + KD+ E + ++++K + +D+
Sbjct: 1804 LSNMQKDLENSNAKLQEKIQELKAN--EHQLITLKKDVNETQKKVSEMEQLKK-QIKDQS 1860
Query: 156 CPELKQEMETL-----LSEAIRLIKSLETDRAD---AEEALKQQRSRKNMINMKIDSWSV 207
K E+E L L E + +KS+ +R + EE LK +R + + + +
Sbjct: 1861 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL 1920
Query: 208 WKLQELPLA--VQKEHEAYLSDVIELQWHLEDKANQL----QHFEKQKTELEEANAKIQA 261
QEL A + KEH+ V +L+ + +K Q+ + +K K EL++ ++Q
Sbjct: 1921 EIQQELKTARMLSKEHK---ETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQK 1977
Query: 262 -DIDYMNEHGPL-LDSKQNQELQDLKNHYKK--------KMEVMDLHRKVNEELEE---- 307
++ + + + K+ E++ LK ++ +M+ L +K++E LEE
Sbjct: 1978 KELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIV 2037
Query: 308 ALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEE 367
A E E R+K + +K E D+ I + I A R+ +Q+ S ++ ++ E
Sbjct: 2038 AKERDELRRIK-ESLKMERDQFIATLREMI-ARDRQNHQVKPEKRLLSDGQQHLTESLRE 2095
Query: 368 KEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYD---QLTWKQKSHEN-QYLEA--VNDF 421
K + E ++ + L+++ DL + + +L+ + K++ + YL+ +
Sbjct: 2096 KCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKL 2155
Query: 422 YAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEI 481
+ A + +E + K + TK+ E+ + INK + + + K+ + +I
Sbjct: 2156 FTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHE---SINKFEMDFIDEVEKQKELLIKI 2212
Query: 482 KYLTI-----------MKLKN--DKHLKNIYKEAYR------------------------ 504
++L +KL D H++ I K+
Sbjct: 2213 QHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFL 2272
Query: 505 ---IGTLFHLTKHKT--DEMEDKIAEVRRKFKGRE-EFLKKLTQGEVAAGMVLQKKLYSI 558
+ T F + K K + D+I +V F R + + T+ E + + ++ +
Sbjct: 2273 EEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDL 2332
Query: 559 YEVQALERKELIKNRAICAMSLAELQEPLLQLEDE-------------AERIRSLD---- 601
++ K L KN SLA + +D E+IR L+
Sbjct: 2333 KSLKEKNEK-LFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLH 2391
Query: 602 --KEHSVSKRSAIFK---DLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKN 656
KE ++ K S I K +LE T AK++E N+ L+ +E T+++L++
Sbjct: 2392 EAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKE-------TIQVLQD 2444
Query: 657 KFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLE 716
K + + + + D M+ K E++ + + F ++ + T+ + QK + L
Sbjct: 2445 K--VALGAKPYKEEIEDLKMKLVKIDLEKM-KNAKEFEKEISATKATV-EYQKEVIRLLR 2500
Query: 717 ENLRLAQEYQQLQI 730
ENLR +Q+ Q +
Sbjct: 2501 ENLRRSQQAQDTSV 2514
Score = 62.0 bits (149), Expect = 2e-09
Identities = 122/604 (20%), Positives = 246/604 (40%), Gaps = 95/604 (15%)
Query: 226 SDVIELQWHLEDKANQLQHFEKQK----TELEEANAKIQADIDYMNEHGPLLDSKQN--- 278
S+V L+ ++DK+ +L +K +E+ +++Q ++ + + L + Q+
Sbjct: 754 SEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYK 813
Query: 279 ---QELQDLKNHY----KKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEID-KDI 330
QE Q+ K + +K V++ + ++N+E+ + + +K E+ K
Sbjct: 814 STDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQ 873
Query: 331 YQDEKTIEAYKR--EIYQLNSLFDHYSSSVINV---NTNIEEKEEEVTEAIRETKSSKNE 385
EKT E +R E+ QL ++ S++ V T I EK ++ E ++ K++
Sbjct: 874 ELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDD 933
Query: 386 LHSLSKML----------------------EDLRRVYDQL--------TWKQKSHE--NQ 413
L L + L E LR + L T K K E ++
Sbjct: 934 LKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSR 993
Query: 414 YLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEI------------DIN 461
L + K + ++ + K + LT D K EI + N
Sbjct: 994 NLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKN 1053
Query: 462 KITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEME- 520
++ I +K + ++++K M ++N + L+ + E + + K+ + E
Sbjct: 1054 ELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEG 1113
Query: 521 ------DKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRA 574
D++AEV K K + + L++ Q + + + I E++ L K +KN+
Sbjct: 1114 ELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENL--KNELKNKE 1171
Query: 575 ICAMSL-AELQEPLLQLEDEAERIRSLDKEHSVSKR------------SAIFKDLEAT-- 619
+ + E E +L + E ++S+ KE V K +++EAT
Sbjct: 1172 LTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGL 1231
Query: 620 KSKTMIFYAKINELNEELKAKEEEKKSF-DQTLEILKNKFITMRFKREHAQTVFDHYMQE 678
++K + A I+ L E + +E ++S ++T +I+ + + + + H QE
Sbjct: 1232 QTKEELKIAHIH-LKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQE 1290
Query: 679 KKDCEERIFEEDQRFRVL-LAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQ---ITFLK 734
+ + E + L L Q T +D+ + + E LRL +++Q+ Q + K
Sbjct: 1291 LLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEM-ERLRLNEKFQESQEEIKSLTK 1349
Query: 735 EKDN 738
E+DN
Sbjct: 1350 ERDN 1353
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 81.6 bits (200), Expect = 3e-15
Identities = 148/750 (19%), Positives = 299/750 (39%), Gaps = 125/750 (16%)
Query: 90 NIPAPCVNKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPG 149
N PA V+ +S +Q++ S +QE L E +RT +++ T +KE
Sbjct: 490 NKPAGDVDMSLSLLQEISS-LQEKL--------EVTRTDHQREI-------TSLKEHFGA 533
Query: 150 EKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWK 209
+ + +E++ L + +L K E+ ++ E A K+ D ++WK
Sbjct: 534 REETHQ-----KEIKALYTATEKLSKENESLKSKLEHANKENS----------DVIALWK 578
Query: 210 LQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEH 269
+L A+ +A + L + F + KT++E+ +DY +E
Sbjct: 579 -SKLETAIASHQQAMEELKVSFSKGL---GTETAEFAELKTQIEKMR------LDYQHE- 627
Query: 270 GPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKD 329
+++ QNQ+ + H K+ + KV +E E +LEA + KA+ +D
Sbjct: 628 ---IENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMED 684
Query: 330 IYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSL 389
+ E +E+ L + + + + N + ++ EE++ + K+S +
Sbjct: 685 TLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEM 744
Query: 390 SKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKL 449
K+ + L Q+ ++LE + ++K S + ++ L T L
Sbjct: 745 KKLRQQLEAAEKQI---------KHLEIEKNAESSK------ASSITRELQGRELKLTNL 789
Query: 450 TEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLF 509
E+ E+ K T++ I K+ E+ + +++ + + K KE F
Sbjct: 790 QENLS--EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQ-----F 842
Query: 510 HLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKEL 569
++ +++ + +A++ KF+ ++E ++L + A L+ + I ++ +L
Sbjct: 843 NMLSSDLEKLRENLADMEAKFREKDEREEQL----IKAKEKLENDIAEIMKMSGDNSSQL 898
Query: 570 IKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSKTMIFYAK 629
K + +++E L+L E L K +D+ ++
Sbjct: 899 TKMNDELRLKERDVEELQLKLTKANENASFLQKS---------IEDMTVKAEQSQ----- 944
Query: 630 INELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEE 689
E K EEEKK ++ L L+ K T + + + ++ E K E I +
Sbjct: 945 ----QEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQN 1000
Query: 690 DQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEK-----DNYFNIYD 744
QKTL DT+ + + EEN L QE ++L+ K K ++ I +
Sbjct: 1001 ----------LQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIME 1050
Query: 745 KQLSLDT----SIRDKKQL-CQLQRRMHTLWQEHFKLV---------VLFSQMRLANFQT 790
+ T S+ D KQ +LQ + TL + + K V + ++ F+
Sbjct: 1051 QMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRK 1110
Query: 791 D-------SQESIQKILAVQEESSNLMQHI 813
+ + + Q++ A+QEE+ L + +
Sbjct: 1111 EIETLKQAAAQKSQQLSALQEENVKLAEEL 1140
Score = 64.3 bits (155), Expect = 4e-10
Identities = 99/426 (23%), Positives = 178/426 (41%), Gaps = 68/426 (15%)
Query: 109 KIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLS 168
K++E+L E F E KD +E+ + +K EK + E+ + S
Sbjct: 851 KLRENLADMEAKFRE-------KDEREE-------QLIKAKEKLENDIAEIMKMSGDNSS 896
Query: 169 EAIRLIKSLETDRADAEEA-LKQQRSRKN--MINMKIDSWSVWKLQELPLAVQKEHEAYL 225
+ ++ L D EE LK ++ +N + I+ +V K ++ K+HE
Sbjct: 897 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTV-KAEQSQQEAAKKHEEEK 955
Query: 226 SDV----IELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQN--- 278
++ +L+ +E NQ Q K + E + K + + N LLD++
Sbjct: 956 KELERKLSDLEKKMETSHNQCQEL-KARYERATSETKTKHEEILQNLQKTLLDTEDKLKG 1014
Query: 279 ---------QELQDLKNHYKKKM------EVMDLHRKVNEELEEALEACENARLKAQQIK 323
QEL++L+ K + M + ++ +E E L + E+ + +++
Sbjct: 1015 AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 1074
Query: 324 EEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINV-NTNIEEKEEEVTEAIRETKSS 382
E+D + K +E +LN S ++ V N +EE +E+ +
Sbjct: 1075 NELDTLKENNLKNVE-------ELNK-----SKELLTVENQKMEEFRKEIETLKQAAAQK 1122
Query: 383 KNELHSLS----KMLEDLRRVYDQLTWKQKSHE------NQYLEAVNDFYAAKKTWDIEL 432
+L +L K+ E+L R D++T QK E NQ LE K D E
Sbjct: 1123 SQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK 1182
Query: 433 SDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKND 492
+ + K +IS+ LTE + +LE N++TV E+ KS + S ++ L K+K +
Sbjct: 1183 ASLQK---SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLH-SVVQTLESDKVKLE 1238
Query: 493 KHLKNI 498
+KN+
Sbjct: 1239 LKVKNL 1244
Score = 42.0 bits (97), Expect = 0.002
Identities = 103/538 (19%), Positives = 216/538 (40%), Gaps = 59/538 (10%)
Query: 310 EACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKE 369
EA + + +Q+ E D + + K +L D + V+ + +++
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLR 414
Query: 370 EEVTEAIRETKSSKNELHSLSKMLEDLR-RVYDQLTWKQKSHENQYLEAVNDFYAAKKTW 428
V A RE N+L + +EDL+ RV ++ K D A +
Sbjct: 415 TMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITK------------GDLEVATVSE 462
Query: 429 DIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMK 488
+ ++ KD ++L ++ E ++LE NK + S+ + S + L + +
Sbjct: 463 KSRIMELEKD---LALRVQEVAELRRRLE--SNKPAGDVDMSLSLLQEISSLQEKLEVTR 517
Query: 489 LKNDKHLKNIYKEAYRIGTLFHLTKHKT-DEMEDKIAEVRRKFKGREEFLKKLTQGEVAA 547
+ + + ++ KE + H + K +K+++ K + E K +A
Sbjct: 518 TDHQREITSL-KEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIAL 576
Query: 548 GMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLE----DEAERIRSLDKE 603
+ + ++ QA+E ++ ++ + AE E Q+E D I +L +
Sbjct: 577 WKSKLETAIASHQ-QAMEELKVSFSKGL-GTETAEFAELKTQIEKMRLDYQHEIENLQNQ 634
Query: 604 HSVSKRSAIFKDLEATKSKTM-IFYAKINEL----NEELKAKEEEKKSFDQTL------E 652
S+R+A K++EA ++K M + K N L ++ KA+++ + TL E
Sbjct: 635 QD-SERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAE 693
Query: 653 ILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIA 712
I + ++ K V D++ + K EE++ + D A+R+ + + ++
Sbjct: 694 IKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD-------ALRKASSEGKSEM-- 744
Query: 713 DSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKK------QLCQLQRRM 766
+ LR E + QI L+ + N + ++ + R+ K L ++ +
Sbjct: 745 ----KKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVK 800
Query: 767 HTLWQEHFKLVVLFSQM--RLANFQTDSQESIQKILAVQEESSNLMQHILGFFQTLTD 822
TL +E L F++ + Q QE++ K+ +E+ + L + + L D
Sbjct: 801 ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD 858
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 81.6 bits (200), Expect = 3e-15
Identities = 148/750 (19%), Positives = 299/750 (39%), Gaps = 125/750 (16%)
Query: 90 NIPAPCVNKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPG 149
N PA V+ +S +Q++ S +QE L E +RT +++ T +KE
Sbjct: 525 NKPAGDVDMSLSLLQEISS-LQEKL--------EVTRTDHQREI-------TSLKEHFGA 568
Query: 150 EKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWK 209
+ + +E++ L + +L K E+ ++ E A K+ D ++WK
Sbjct: 569 REETHQ-----KEIKALYTATEKLSKENESLKSKLEHANKENS----------DVIALWK 613
Query: 210 LQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEH 269
+L A+ +A + L + F + KT++E+ +DY +E
Sbjct: 614 -SKLETAIASHQQAMEELKVSFSKGL---GTETAEFAELKTQIEKMR------LDYQHE- 662
Query: 270 GPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKD 329
+++ QNQ+ + H K+ + KV +E E +LEA + KA+ +D
Sbjct: 663 ---IENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMED 719
Query: 330 IYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSL 389
+ E +E+ L + + + + N + ++ EE++ + K+S +
Sbjct: 720 TLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEM 779
Query: 390 SKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKL 449
K+ + L Q+ ++LE + ++K S + ++ L T L
Sbjct: 780 KKLRQQLEAAEKQI---------KHLEIEKNAESSK------ASSITRELQGRELKLTNL 824
Query: 450 TEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLF 509
E+ E+ K T++ I K+ E+ + +++ + + K KE F
Sbjct: 825 QENLS--EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQ-----F 877
Query: 510 HLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKEL 569
++ +++ + +A++ KF+ ++E ++L + A L+ + I ++ +L
Sbjct: 878 NMLSSDLEKLRENLADMEAKFREKDEREEQL----IKAKEKLENDIAEIMKMSGDNSSQL 933
Query: 570 IKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSKTMIFYAK 629
K + +++E L+L E L K +D+ ++
Sbjct: 934 TKMNDELRLKERDVEELQLKLTKANENASFLQKS---------IEDMTVKAEQSQ----- 979
Query: 630 INELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEE 689
E K EEEKK ++ L L+ K T + + + ++ E K E I +
Sbjct: 980 ----QEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQN 1035
Query: 690 DQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEK-----DNYFNIYD 744
QKTL DT+ + + EEN L QE ++L+ K K ++ I +
Sbjct: 1036 ----------LQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIME 1085
Query: 745 KQLSLDT----SIRDKKQL-CQLQRRMHTLWQEHFKLV---------VLFSQMRLANFQT 790
+ T S+ D KQ +LQ + TL + + K V + ++ F+
Sbjct: 1086 QMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRK 1145
Query: 791 D-------SQESIQKILAVQEESSNLMQHI 813
+ + + Q++ A+QEE+ L + +
Sbjct: 1146 EIETLKQAAAQKSQQLSALQEENVKLAEEL 1175
Score = 64.3 bits (155), Expect = 4e-10
Identities = 99/426 (23%), Positives = 178/426 (41%), Gaps = 68/426 (15%)
Query: 109 KIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLS 168
K++E+L E F E KD +E+ + +K EK + E+ + S
Sbjct: 886 KLRENLADMEAKFRE-------KDEREE-------QLIKAKEKLENDIAEIMKMSGDNSS 931
Query: 169 EAIRLIKSLETDRADAEEA-LKQQRSRKN--MINMKIDSWSVWKLQELPLAVQKEHEAYL 225
+ ++ L D EE LK ++ +N + I+ +V K ++ K+HE
Sbjct: 932 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTV-KAEQSQQEAAKKHEEEK 990
Query: 226 SDV----IELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQN--- 278
++ +L+ +E NQ Q K + E + K + + N LLD++
Sbjct: 991 KELERKLSDLEKKMETSHNQCQEL-KARYERATSETKTKHEEILQNLQKTLLDTEDKLKG 1049
Query: 279 ---------QELQDLKNHYKKKM------EVMDLHRKVNEELEEALEACENARLKAQQIK 323
QEL++L+ K + M + ++ +E E L + E+ + +++
Sbjct: 1050 AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 1109
Query: 324 EEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINV-NTNIEEKEEEVTEAIRETKSS 382
E+D + K +E +LN S ++ V N +EE +E+ +
Sbjct: 1110 NELDTLKENNLKNVE-------ELNK-----SKELLTVENQKMEEFRKEIETLKQAAAQK 1157
Query: 383 KNELHSLS----KMLEDLRRVYDQLTWKQKSHE------NQYLEAVNDFYAAKKTWDIEL 432
+L +L K+ E+L R D++T QK E NQ LE K D E
Sbjct: 1158 SQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK 1217
Query: 433 SDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKND 492
+ + K +IS+ LTE + +LE N++TV E+ KS + S ++ L K+K +
Sbjct: 1218 ASLQK---SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLH-SVVQTLESDKVKLE 1273
Query: 493 KHLKNI 498
+KN+
Sbjct: 1274 LKVKNL 1279
Score = 38.9 bits (89), Expect = 0.020
Identities = 104/561 (18%), Positives = 222/561 (39%), Gaps = 70/561 (12%)
Query: 310 EACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKE 369
EA + + +Q+ E D + + K +L D + V+ + +++
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLR 414
Query: 370 EEVTEAIRETKSSKNELHSLSKMLEDLR-RVYDQLTWK---------------------- 406
V A RE N+L + +EDL+ RV ++ K
Sbjct: 415 TMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLL 474
Query: 407 -QKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITV 465
+K+ ++ + D A + + ++ KD ++L ++ E ++LE NK
Sbjct: 475 FEKTKADKLQRELEDTRVATVSEKSRIMELEKD---LALRVQEVAELRRRLE--SNKPAG 529
Query: 466 KTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKT-DEMEDKIA 524
+ S+ + S + L + + + + + ++ KE + H + K +K++
Sbjct: 530 DVDMSLSLLQEISSLQEKLEVTRTDHQREITSL-KEHFGAREETHQKEIKALYTATEKLS 588
Query: 525 EVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQ 584
+ K + E K +A + + ++ QA+E ++ ++ + AE
Sbjct: 589 KENESLKSKLEHANKENSDVIALWKSKLETAIASHQ-QAMEELKVSFSKGL-GTETAEFA 646
Query: 585 EPLLQLE----DEAERIRSLDKEHSVSKRSAIFKDLEATKSKTM-IFYAKINEL----NE 635
E Q+E D I +L + S+R+A K++EA ++K M + K N L ++
Sbjct: 647 ELKTQIEKMRLDYQHEIENLQNQQD-SERAAHAKEMEALRAKLMKVIKEKENSLEAIRSK 705
Query: 636 ELKAKEEEKKSFDQTL------EILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEE 689
KA+++ + TL EI + ++ K V D++ + K EE++ +
Sbjct: 706 LDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL 765
Query: 690 DQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSL 749
D A+R+ + + ++ + LR E + QI L+ + N + ++
Sbjct: 766 D-------ALRKASSEGKSEM------KKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 812
Query: 750 DTSIRDKK------QLCQLQRRMHTLWQEHFKLVVLFSQM--RLANFQTDSQESIQKILA 801
+ R+ K L ++ + TL +E L F++ + Q QE++ K+
Sbjct: 813 ELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 872
Query: 802 VQEESSNLMQHILGFFQTLTD 822
+E+ + L + + L D
Sbjct: 873 KEEQFNMLSSDLEKLRENLAD 893
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 81.3 bits (199), Expect = 3e-15
Identities = 164/737 (22%), Positives = 317/737 (43%), Gaps = 147/737 (19%)
Query: 150 EKRDEKCPELKQEMETLLSEAIR-----LIKSLETDRADA---EEALKQQRS---RKNMI 198
+K +C EL++E+E L S+ + +IK+L T+R DA E+A +Q+ +K I
Sbjct: 42 QKAKSRCTELEKEIEELRSKPVTEGTGDIIKAL-TERLDALLLEKAETEQQCLSLKKENI 100
Query: 199 NMKID-SWSVWKLQELPLAVQKEHEAYLSDVIELQWHL--------EDKAN-QLQHFEKQ 248
MK + SV K+ + +++ H Y+ ++ L+ L EDKAN Q Q E
Sbjct: 101 KMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAM 160
Query: 249 KTELE-----------EANA-KIQADID-----------YMNEHGPLLDSKQNQELQDLK 285
T+LE E N K+Q +I+ Y+ + ++ + + L+
Sbjct: 161 NTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQ 220
Query: 286 N-------HYKKK--------MEVMDLHRKVNEELEEALEAC----ENARLKAQQIKEEI 326
N HY+K +++ +H++ +EL +EA E K ++KE +
Sbjct: 221 NIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENL 280
Query: 327 DKDIYQDEKTIE-AYKREIYQLNSLFDHYS------SSVINVNTNIEEKEEEVTEAIRET 379
K EK I+ Y+ E+ L + + S ++ NT + E+ V E ++
Sbjct: 281 VKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFV---EQVVNEKVKHL 337
Query: 380 KSSKNELHSLSKMLEDLRRVYDQLTWKQKS----------HENQYLE-AVNDFYAAKKTW 428
+ + EL S +L+D + L K + HE + LE +N+ AK+
Sbjct: 338 EDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQ 397
Query: 429 DIELSDVAKDFSAISLA-CTKLTEDNKK---LEIDINKITVKTNESIRKKSKYESEIKYL 484
+ + + + ++ C + + N++ L+ K + NE+ S+ E
Sbjct: 398 GCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF 457
Query: 485 TIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGE 544
I LK + +N+ +E + + + ++ ++ E K E +K+ +
Sbjct: 458 EIQGLK--EQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASD 515
Query: 545 VAAGMVLQKKLYSIY-EVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKE 603
V LQ+KL + + E AL E + L QE + +LE+ + ++ +
Sbjct: 516 VHE---LQQKLRTAFTEKDAL--LETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGV 570
Query: 604 H--SVSKRSAIFKDLEATKSKTMIFYAKINELNEE-------LKAKEEEKKSFDQTLEIL 654
+ S+S+R + K+LE KIN L EE LK EE +F + E
Sbjct: 571 YLLSLSQRDTMLKELE----------GKINSLTEEKDDFINKLKNSHEEMDNFHKKCE-- 618
Query: 655 KNKFITMRFKREHAQTV-FDHYMQEKKD-----CEERIFEEDQRFRVL--LAVRQKTLQD 706
+ + + + ++ QT+ ++ +++K + EE + E+DQ + L L V+ K L +
Sbjct: 619 REERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSE 678
Query: 707 TQKIIADSL----EENLRLAQEYQQLQ---ITFLKEKDNYFNIYDKQLSLDTSIRDKKQL 759
+++++ + EEN +L+ E +QL FL +K++ + K+ +
Sbjct: 679 DKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKED--------------VILKEHI 724
Query: 760 CQLQRRMHTLWQEHFKL 776
QL++++ + +E L
Sbjct: 725 TQLEKKLQLMVEEQDNL 741
Score = 66.2 bits (160), Expect = 1e-10
Identities = 151/748 (20%), Positives = 316/748 (42%), Gaps = 101/748 (13%)
Query: 98 KMISHIQDVESKIQEHLKRFETSFEE-----WSRTSSTKDLKEDWSVTTPVKEVKPGEKR 152
K ++ +D K+QE +++ FEE + +T D K++ +VT ++ +
Sbjct: 171 KFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKE-TVTQLQNIIEANSQH 229
Query: 153 DEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQE 212
+K QE E L +AI + ++ E + K+ + N +N ++ V + +
Sbjct: 230 YQKNINSLQE-ELLQLKAIHQ-EEVKELMCQIEASAKEHEAEINKLN-ELKENLVKQCEA 286
Query: 213 LPLAVQKEHEAYL-----------------SDVIELQWHLEDKANQ-LQHFEKQKTELEE 254
+QK++E L S +++ +E N+ ++H E ELE
Sbjct: 287 SEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELES 346
Query: 255 ANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACEN 314
++ ++ ++ YMN L K + Q +K+ + + E DL K+N E L A E
Sbjct: 347 QHSILKDEVTYMNN----LKLKLEMDAQHIKDEFFHERE--DLEFKIN----ELLLAKEE 396
Query: 315 ARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVN-TNIEEKEEEVT 373
+++K E+ Q T+E + RE+ SL + + + +N T + + E+E
Sbjct: 397 QGCVIEKLKSELAGLNKQFCYTVEQHNREV---QSLKEQHQKEISELNETFLSDSEKEKL 453
Query: 374 EAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAV----NDFYAAKKTWD 429
+ E + K + +L + ++ Y+ L + + + E+ +F + K+
Sbjct: 454 TLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQA 513
Query: 430 IELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKL 489
++ ++ + T TE + LE +N++ + NE + + + E++ TI L
Sbjct: 514 SDVHELQQKLR------TAFTEKDALLE-TVNRLQGE-NEKLLSQQELVPELEN-TIKNL 564
Query: 490 --KNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAA 547
KN +L ++ + + L T+E +D I +++ + + F KK + E
Sbjct: 565 QEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLI 624
Query: 548 GMVLQKKLYSIYEVQALERK---------ELIKNRAICAMSLAELQEPLLQLEDEAE--- 595
+ +K +I LE+K E +K + L +L + L ++ E
Sbjct: 625 LELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLS 684
Query: 596 -RIRSLDKEHS--VSKRSAIFKDLEA--TKSKTMIFYAKINELNEELKAKEEEKKSFDQT 650
++SL +E++ S++ + +DLE ++ + +I I +L ++L+ EE+ D
Sbjct: 685 AEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQ---DNL 741
Query: 651 LEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQK-------- 702
++L+N+ + F +T +++E EE VL AV +
Sbjct: 742 NKLLENEQVQKLF----VKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEK 797
Query: 703 ---TLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKKQL 759
Q +K++ LE+ ++ QE +Q LK + Y+++ + +K+L
Sbjct: 798 CNLAFQRDEKVL--ELEKEIKCLQEESVVQCEELK---SLLRDYEQE-----KVLLRKEL 847
Query: 760 CQLQRRMHTLWQEHFKLVVLFSQMRLAN 787
++Q L + ++ + RL N
Sbjct: 848 EEIQSEKEALQSDLLEMKNANEKTRLEN 875
Score = 66.2 bits (160), Expect = 1e-10
Identities = 110/572 (19%), Positives = 231/572 (40%), Gaps = 64/572 (11%)
Query: 142 PVKEVKPGEKR----DEKCPELKQEMETLLSEAIRLIKSLETDRADAE---EALKQQRSR 194
P+ VK E++ +++C E ++++ + A++ K L++ R + + E L+ RS
Sbjct: 942 PLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSE 1001
Query: 195 KNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIE-----LQWHLEDKANQLQHFEKQK 249
K+ ++ + L ++ E ++ DV + + +ED QL++ Q
Sbjct: 1002 KDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQC 1061
Query: 250 TELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHR--KVNE---- 303
+ N + A I+ + + LL+ Q E+Q K K++E L + K+ E
Sbjct: 1062 ETINSDNEDLLARIETLQSNAKLLEV-QILEVQRAKAMVDKELEAEKLQKEQKIKEHATT 1120
Query: 304 --ELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINV 361
ELEE + + + Q+ +E++ + +D + EI L + + N
Sbjct: 1121 VNELEELQVQLQKEKKQLQKTMQELEL-VKKDAQQTTLMNMEIADYERLMKELNQKLTNK 1179
Query: 362 NTNIEEKEEEVTEAIRETKSSKNELHSLS---KMLEDLRRVYDQLTWKQKSHENQYLEAV 418
N IE+ E+E+ ++ ++ + E+ SL + E+ QL K K +A
Sbjct: 1180 NNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAE 1239
Query: 419 NDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYE 478
D + + EL + + ++T + K+ + + R S Y+
Sbjct: 1240 TDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIH---EHLKTSAEQHQRTLSAYQ 1296
Query: 479 SEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLK 538
+ L +E R T T E E V K ++ K
Sbjct: 1297 QRVTAL---------------QEECRAAKAEQAT--VTSEFESYKVRVHNVLKQQKN--K 1337
Query: 539 KLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIR 598
++Q E ++ L + + ++ ++ N I +++ELQ + + ER
Sbjct: 1338 SMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQI---NVSELQTLQSEHDTLLERHN 1394
Query: 599 SLDKEHSVSKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKF 658
+ +E +VSK + + + L + +S+ M+ ++ + +L ++ E+L+N F
Sbjct: 1395 KMLQE-TVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQN----------EVLRNSF 1443
Query: 659 --ITMRFKREHAQTVFDHYMQEKKDCEERIFE 688
+ EH +TV + Q+ E ++F+
Sbjct: 1444 RDQVRHLQEEHRKTV-ETLQQQLSKMEAQLFQ 1474
Score = 65.1 bits (157), Expect = 3e-10
Identities = 171/812 (21%), Positives = 338/812 (41%), Gaps = 143/812 (17%)
Query: 102 HIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQ 161
H ++V+S ++H K E + T + KE ++ ++ +K E+C L+Q
Sbjct: 422 HNREVQSLKEQHQKEIS----ELNETFLSDSEKEKLTLMFEIQGLK------EQCENLQQ 471
Query: 162 E-METLLS-EAIR-LIKSLETDRADAE-------EALKQQR-SRKNMINMKIDSWSVWK- 209
E E +L+ E++R +++ L+T+ ++ E++KQQ+ S + + K+ + K
Sbjct: 472 EKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKD 531
Query: 210 -LQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQH--------FEKQKTELEEANAKIQ 260
L E +Q E+E LS EL LE+ LQ ++ T L+E KI
Sbjct: 532 ALLETVNRLQGENEKLLSQQ-ELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKIN 590
Query: 261 ADIDYMNEHGPLLDSKQNQELQDLKNHYKK-------------KMEVM-----DLHRKVN 302
+ + E +K +++ N +KK K+E +L +KVN
Sbjct: 591 S----LTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVN 646
Query: 303 E---ELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVI 359
E LEE L+ + K +++ ++ K + +D++ + A + +Y+ N+ +
Sbjct: 647 ELTGGLEETLKEKDQNDQKLEKLMVQM-KVLSEDKEVLSAEVKSLYEENNKLSSEKKQL- 704
Query: 360 NVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVN 419
++ EV + +E K + L K L+ + D L ++ + Q L
Sbjct: 705 -------SRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKT 757
Query: 420 DFYAAKKTWDIELS------DVAKDFSAISLACTKLTE---------DNKKLEIDINKIT 464
Y K E+S DV A+ + K+ E D K LE++ +I
Sbjct: 758 QLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELE-KEIK 816
Query: 465 VKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIY--KEAYRIGTLFHLTKHKTDEMEDK 522
ES+ + + +S ++ K+ K L+ I KEA + L ++ +E++
Sbjct: 817 CLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQ 876
Query: 523 -----IAEVRRKFKGREEFLKK----LTQGEVAAGMVLQKKLYSIYEVQALERKELIKNR 573
+ EV + E +K + + E ++ QK+L R ELI +
Sbjct: 877 NLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRD-------RRAELILLK 929
Query: 574 AICAMSLAELQEPLLQLEDEAERIRSL-----DKEHSVSKRSAIF----KDLEATKSKTM 624
A S + +PL +++ E+I +L +KE ++K + K+L++++ +T
Sbjct: 930 DSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQ 989
Query: 625 IFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEE 684
++ L E + Q E KN + + ++++ Q D + + E
Sbjct: 990 TVKEELESLRSEKDQLSASMRDLIQGAESYKN--LLLEYEKQSEQ--LDVEKERANNFEH 1045
Query: 685 RIFEEDQRFRVLLAVRQKTLQDTQKIIA--DSLEENLRLAQEYQQLQITFLKEKDNYFNI 742
RI + ++ R + D + ++A ++L+ N +L E Q L++ K +
Sbjct: 1046 RIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLL-EVQILEVQRAKA------M 1098
Query: 743 YDKQLSLD------------TSIRDKKQL-CQLQRRMHTLWQ--EHFKLVVLFSQ----- 782
DK+L + T++ + ++L QLQ+ L + + +LV +Q
Sbjct: 1099 VDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLM 1158
Query: 783 -MRLANFQTDSQESIQKILAVQEESSNLMQHI 813
M +A+++ +E QK+ + +L Q I
Sbjct: 1159 NMEIADYERLMKELNQKLTNKNNKIEDLEQEI 1190
Score = 34.3 bits (77), Expect = 0.49
Identities = 55/263 (20%), Positives = 105/263 (39%), Gaps = 35/263 (13%)
Query: 560 EVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEAT 619
+++ L +++LIK M + + + +LE E E +RS
Sbjct: 21 KLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRS-------------------- 60
Query: 620 KSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEK 679
K T I L E L A EK +Q LK + I M+ + E + T +E
Sbjct: 61 KPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKEL 120
Query: 680 KDCEERIFEEDQRFR-VLLAVRQKTLQD---TQKIIADSLEENLRLAQE----------Y 725
+ +E + + L+AVR K +D QK + +++ L L+++
Sbjct: 121 EQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNV 180
Query: 726 QQLQITFLKEKDNY-FNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMR 784
++LQ K + + I Q LD + +KK+ + + +H++ + Q
Sbjct: 181 KKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEE 240
Query: 785 LANFQTDSQESIQKILAVQEESS 807
L + QE +++++ E S+
Sbjct: 241 LLQLKAIHQEEVKELMCQIEASA 263
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 81.3 bits (199), Expect = 3e-15
Identities = 148/775 (19%), Positives = 315/775 (40%), Gaps = 140/775 (18%)
Query: 96 VNKM---ISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKR 152
+NK+ IS D ++E + + + + ++K LK+ +K E
Sbjct: 486 INKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESL 545
Query: 153 DEKCPELKQEMETLLSEAIR--LIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKL 210
+E+ +LK+++ + E + L T+ + E + Q + K+D S+ +
Sbjct: 546 EEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQG---DRISERKLDLLSLKNM 602
Query: 211 QELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHG 270
E Q ++E ++IE + LE + F+ + EL E N +++ + +
Sbjct: 603 SE----AQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEI---- 654
Query: 271 PLLDSKQNQELQDLKNHYKKKMEVMDLHRKVN----EELEEALEACENARLKAQQI---K 323
L K+ Q+ D+K + + + L R VN + E +A + + + Q+
Sbjct: 655 -LQAIKEMQKDPDVKGG-ETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRN 712
Query: 324 EEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTN------------------- 364
EE+ +++ + K Y +++ + N DH + +
Sbjct: 713 EELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPS 772
Query: 365 ----IEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVND 420
I + E + ++E ++ + +L +L LED R + + +Q +YL
Sbjct: 773 SASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYL----- 827
Query: 421 FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESE 480
+ K+TW E + E+ +KLE + + +K E Y +
Sbjct: 828 --SEKETWKTESKTIK--------------EEKRKLEDQVQQDAIKVKE-------YNN- 863
Query: 481 IKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKK- 539
L +++ +D+ +K I E R T+ + + + E+ R+ + E K
Sbjct: 864 --LLNALQMDSDE-MKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNE 920
Query: 540 --LTQGEVAA--GMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAE 595
+ EV G + + K +I+++ AL++ ++ N ++SL+EL+ Q +
Sbjct: 921 LLSMEAEVCEKIGCLQRFKEMAIFKIAALQK--VVDN----SVSLSELELANKQYNELTA 974
Query: 596 RIRS-LDKEHSVSKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLE-- 652
+ R L K++ + +R++ +LE + + + ++ +N+EL+ +E+ + +Q E
Sbjct: 975 KYRDILQKDNMLVQRTS---NLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQE 1031
Query: 653 -----------------------------ILKNKFITMRFKREHAQTVFDHYMQEKKDCE 683
+L+ K + R + EH Q +++H K E
Sbjct: 1032 TKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQME 1091
Query: 684 ERIFEEDQRFRVLLAVR---QKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYF 740
ER FE + +F L + QK Q + +ADS+ + + A + L++ EK+
Sbjct: 1092 ERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILEL----EKN--- 1144
Query: 741 NIYDKQLSLDTS-IRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQE 794
+ +L ++ S +R+ + + Q + Q+ V +M+L ++Q S E
Sbjct: 1145 ---EMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDE 1196
Score = 62.0 bits (149), Expect = 2e-09
Identities = 149/738 (20%), Positives = 291/738 (39%), Gaps = 136/738 (18%)
Query: 190 QQRSRKNMINMKIDSWSVWKL--QELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEK 247
+ ++N+I++ + S+ K+ QE+ LA+++ +A + + + L+ K +L++
Sbjct: 41 KSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAG-EEQAKFENQLKTKVMKLEN--- 96
Query: 248 QKTELEEANAKIQA-DIDYMNEHGPLLDSKQNQ---ELQDLKNHYKKKMEVMDLHRKVNE 303
ELE A D ++ L+ + Q EL+D++ +K+ +V + NE
Sbjct: 97 ---ELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNE 153
Query: 304 ELEEALEAC--ENARLKAQQIKEEIDKDIYQDEKTIEAYKREI----------------- 344
E E EN RLK + E++ +DI +K I++ K +
Sbjct: 154 EAENENSKLRRENKRLKKK--NEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKK 211
Query: 345 -YQLNSLFDHYSSSVINVNTNIEEKEEE----VTEAIRETKSSKNELHSLSKMLEDLRRV 399
Y+L D ++ N IE + +E + E+++E + +E + + ++ V
Sbjct: 212 NYELIQYLDEI-QTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNV 270
Query: 400 YDQLTWKQKSHENQYLEAVNDFYAAK---------------KTWDIELSDVAKDFSAISL 444
DQL K+ H ++ + D +K + W + LS +
Sbjct: 271 IDQLK-KENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQ 329
Query: 445 ACTKLTEDNKKLEIDINKITVKT-NESIRKKSKYESEIKYLT----------------IM 487
L E K ++D +K V + I+++ +S+IK LT I
Sbjct: 330 MLHNLREKLKNAQLDADKSNVMALQQGIQER---DSQIKMLTEQVEQYTKEMEKNTCIIE 386
Query: 488 KLKND----KHLKNIYKEAY-RIGTLFHLTKHKTDEMEDKI----AEVRRKFKGREEFLK 538
LKN+ K + ++ + +I + + K KT E E A+ R K K E LK
Sbjct: 387 DLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALK 446
Query: 539 KLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNR--AICAMSLAELQEPLLQLEDEAER 596
+L E + ++ E++ + + I++R I + +L+ + DE E
Sbjct: 447 RLKDYESGVYGLED----AVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEA 502
Query: 597 IRS--------------------LDKEHSVSKRSAIFKDLEATKSKTMIFYAKINELNEE 636
+R L ++ ++ + K++E+ + + + KI ++ +E
Sbjct: 503 LRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQE 562
Query: 637 LKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEE----RIFEED-- 690
+ + L + +N R + M E + E + E++
Sbjct: 563 RGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERD 622
Query: 691 -QRFRVLLAVRQ---KTLQDTQKIIADSLEENLRLAQEYQQ----------LQITFLKEK 736
+R R ++A Q K L + K + + ++E L+ +E Q+ L I L+
Sbjct: 623 LERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERL 682
Query: 737 DNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQE----HFKLVVLFSQMRLANFQTDS 792
N + + D S+ K Q+ QL R L QE + + Q+ AN + D
Sbjct: 683 VNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDH 742
Query: 793 QESIQKILAVQEESSNLM 810
E +L Q E SN++
Sbjct: 743 LEKETSLLR-QSEGSNVV 759
Score = 58.2 bits (139), Expect = 3e-08
Identities = 161/763 (21%), Positives = 305/763 (39%), Gaps = 88/763 (11%)
Query: 100 ISHIQDVESKIQEHLK-RFETSFEEWSR--TSSTKDLKEDWSVTTPVKEVKPGEKRDEKC 156
+ ++ D K + LK + E SR T++ ++L E +KE K +
Sbjct: 1690 LKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKE-KQQKALSRAL 1748
Query: 157 PELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLA 216
EL+ EM E I S + + ++ + + +R+ ++ + ++ KL+E L
Sbjct: 1749 LELRAEMTAAAEERIISATSQKEAHLNVQQIV-DRHTRELKTQVEDLNENLLKLKEA-LK 1806
Query: 217 VQKEHEAYLSDVI-ELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMN---EHGPL 272
K E L+D + +L L+ K ++K E+++ N +++ I + + PL
Sbjct: 1807 TSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPL 1866
Query: 273 LDSKQN--QELQ----DLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEI 326
D+KQ+ +ELQ L+N + K+E +DL + +E L E + K Q E I
Sbjct: 1867 TDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGK-KWQAKIEGI 1925
Query: 327 DKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEA--IRETKSSKN 384
+ + E + +++ L LF + + ++ V + IR +S K
Sbjct: 1926 RNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEK- 1984
Query: 385 ELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISL 444
EL L K DL + + + + V D + + +L + K FS +
Sbjct: 1985 ELEELKKRNLDLE---NDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTY 2041
Query: 445 ACTKLT----EDNKKLEIDINKITVK-TNESIRKKSKYESEIKYLTIMK----------- 488
+ ++ +D+ + E ++ K +K ++E+I K + E K L +K
Sbjct: 2042 SKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCE 2101
Query: 489 -LKNDK--------HLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKK 539
LK +K H++ + I L KT + K+ E K + E LKK
Sbjct: 2102 FLKKEKAEVQRKLGHVRGSGRSGKTIPEL-----EKTIGLMKKVVE---KVQRENEQLKK 2153
Query: 540 LTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLED----EAE 595
A+G++ +K+ +I + + EL K +A L+ E + + E E
Sbjct: 2154 ------ASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENE 2207
Query: 596 RIRS-LDKEHSVSKRSAIFKD-LEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEI 653
R+R L KE +++ I K+ LE K + ++ E + L+ E +
Sbjct: 2208 RLRKELKKETDAAEKLRIAKNNLEILNEKMTV---QLEETGKRLQFAESRGPQLEGADSK 2264
Query: 654 LKNKFITMRF---KREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQ-- 708
+ R K + +T Q D ++ + E +R + + + Q +
Sbjct: 2265 SWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKIL 2324
Query: 709 KIIADSLEENLRLAQEYQQLQIT---FLKEKDNYFNIYDK---QLSLDTSIRDKKQL--- 759
K + + E L +E Q L++ KEK + + Q +++I D QL
Sbjct: 2325 KHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEK 2384
Query: 760 ---CQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKI 799
+ Q +M L ++H K + + L NF E I+ +
Sbjct: 2385 IKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDL 2427
Score = 52.0 bits (123), Expect = 2e-06
Identities = 129/652 (19%), Positives = 263/652 (40%), Gaps = 90/652 (13%)
Query: 174 IKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQW 233
I+SL + A +Q++ K MI ++ D + +QE+ + Q+EH + +E++
Sbjct: 1267 IQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKI--MQEMKNS-QQEHRNMENKTLEMEL 1323
Query: 234 HLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKME 293
L+ + + K + N ++ E L + K N+EL K K
Sbjct: 1324 KLKGLEELISTLKDTKGAQKVINWHMKI------EELRLQELKLNRELVKDKEEIKYLNN 1377
Query: 294 VMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDH 353
++ + + LEE + QQ K ++ + D++ ++ +R++ +FD
Sbjct: 1378 IISEYERTISSLEEEI---------VQQNKFHEERQMAWDQREVD-LERQL----DIFDR 1423
Query: 354 YSSSVINVNTNIEEKEEEVTEAIRE-TKSSKNELH-SLSKMLEDLRRVYD------QLTW 405
+ ++N +K EE T +I + + N+L +L K+ E++R + + L
Sbjct: 1424 QQNEILNA----AQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEE 1479
Query: 406 KQKSHENQYLEAVNDFYAAKKTWD---IELSDVAKDFSAISLACTKLTEDNKKLEIDINK 462
K K E+ A + + K + + L A+ I+ K E + I
Sbjct: 1480 KLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAH 1539
Query: 463 ITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDK 522
T+ N R K E KY +++ ++ + + K + L H + + D +K
Sbjct: 1540 QTI-ANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNK 1598
Query: 523 IAEVR--------RKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRA 574
+ + F++ + A L S+ ++L + R
Sbjct: 1599 FKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQ--DDSLSSLLVKLKKVSQDLERQRE 1656
Query: 575 ICAMSLAELQEPLLQL----EDEAERIRS--------LDKEHSVSK--RSAIFKDLEA-T 619
I + + E + LQL EDE +++++ LD+ S+ +S + EA +
Sbjct: 1657 ITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANS 1716
Query: 620 KSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILK--------NKFITMRFKRE---HA 668
++ T + L +L KE+++K+ + L L+ + I+ ++E +
Sbjct: 1717 RAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNV 1776
Query: 669 QTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQL 728
Q + D + +E K E + E + + L KT ++ + + D+L + Q+ Q+
Sbjct: 1777 QQIVDRHTRELKTQVEDLNENLLKLKEAL----KTSKNRENSLTDNLNDLNNELQKKQKA 1832
Query: 729 QITFLKEKDNYFNIYD---KQLSLDTS------IRDKKQ--LCQLQRRMHTL 769
L+EK+ D +Q+ TS + D KQ + +LQR++ L
Sbjct: 1833 YNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKL 1884
Score = 51.2 bits (121), Expect = 4e-06
Identities = 119/671 (17%), Positives = 250/671 (37%), Gaps = 115/671 (17%)
Query: 97 NKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKD-LKEDWSVTTPVKEVKPGEKRDEK 155
N + ++ D+ +++Q+ K + E D LK T + KP
Sbjct: 1813 NSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKP------- 1865
Query: 156 CPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPL 215
L ++L+ E R +K LE E + + ++ ++ W K + +
Sbjct: 1866 ---LTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKI 1922
Query: 216 A------VQKEHEAY--------LSDV--------IELQWHLEDKANQLQHF-------- 245
+KE E + L D+ + LQ L+ +
Sbjct: 1923 EGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALES 1982
Query: 246 EKQKTELEEANAKIQADIDYMNEHGPL-LDS------KQNQELQDLKNHYKKKMEVMDLH 298
EK+ EL++ N ++ DI YM H L DS QN+ LQ+ K H +K D +
Sbjct: 1983 EKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQE-KLHALEKQFSKDTY 2041
Query: 299 RKVNEELEEALEAC--------ENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSL 350
K + E+ + C EN +L ++ I E+ + Q K + K ++ L +
Sbjct: 2042 SKPSISGIESDDHCQREQELQKENLKLSSENI--ELKFQLEQANKDLPRLKNQVRDLKEM 2099
Query: 351 FDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSH 410
+ V + +R + S + L K + +++V +++
Sbjct: 2100 CEFLKKEKAEVQRKLGH--------VRGSGRSGKTIPELEKTIGLMKKVVEKV-----QR 2146
Query: 411 ENQYLEAVNDFYAAKKTWDIELSD-----------------VAKDFSAISLACTKLTEDN 453
EN+ L+ + ++K +IE + ++ + + + K+ +N
Sbjct: 2147 ENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAEN 2206
Query: 454 KKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDK----------HLKNIYKEAY 503
++L ++ K T + K+ E + +T+ + K L+ +++
Sbjct: 2207 ERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSW 2266
Query: 504 RIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMV---LQKKLYSIYE 560
+ + + + K E+E IA+ + ++ +K+ T+ E L++++ +
Sbjct: 2267 KSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKH 2326
Query: 561 VQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATK 620
V E R + + LA Q +++AE I ++ S + D + K
Sbjct: 2327 VPEGAETEQGLKRELQVLRLANHQLD----KEKAELIHQIEANKDQSGAESTIPDADQLK 2382
Query: 621 SKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKK 680
KI +L +LK + EK+ + ++ LK + F + + D K+
Sbjct: 2383 E-------KIKDLETQLKMSDLEKQHLKEEIKKLKKEL--ENFDPSFFEEIEDLKYNYKE 2433
Query: 681 DCEERIFEEDQ 691
+ ++ I E++
Sbjct: 2434 EVKKNILLEEK 2444
Score = 48.5 bits (114), Expect = 2e-05
Identities = 42/196 (21%), Positives = 98/196 (50%), Gaps = 17/196 (8%)
Query: 115 KRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLI 174
+ +ET +E T K++ S+T + VK +R++K + +++E + I+++
Sbjct: 2273 RMYETKLKELE----TDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLE----QQIKIL 2324
Query: 175 KSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAV-QKEHEAYLSDVIELQW 233
K + + A+ E+ LK++ + N ++D + ++ Q E+ + D +L+
Sbjct: 2325 KHVP-EGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKE 2383
Query: 234 HLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKME 293
++D QL+ + +K L+E K++ +++ D +E++DLK +YK++++
Sbjct: 2384 KIKDLETQLKMSDLEKQHLKEEIKKLKKELENF-------DPSFFEEIEDLKYNYKEEVK 2436
Query: 294 VMDLHRKVNEELEEAL 309
L + ++L E L
Sbjct: 2437 KNILLEEKVKKLSEQL 2452
Score = 45.4 bits (106), Expect = 2e-04
Identities = 124/636 (19%), Positives = 254/636 (39%), Gaps = 107/636 (16%)
Query: 103 IQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQE 162
I+D+++++Q + S + + ST D+ ++ + K E+ E +E
Sbjct: 385 IEDLKNELQRNKGASTLSQQTHMKIQSTLDILKE--------KTKEAERTAELAEADARE 436
Query: 163 METLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHE 222
+ L EA++ +K E+ E+A+ + ++ KN I ++ +E E
Sbjct: 437 KDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIR----------------DREIE 480
Query: 223 AYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQ 282
++ +L+ + D ++ + +++ LE K D+ L + E Q
Sbjct: 481 ILTKEINKLELKISDFLDENEAL-RERVGLE---PKTMIDLTEFRNSKHLKQQQYRAENQ 536
Query: 283 D-LKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYK 341
LK + E +DL +K+ + +E + + L + + + ++I Q ++ I K
Sbjct: 537 ILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDL--NLTENISQGDR-ISERK 593
Query: 342 REIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYD 401
++ L ++ + S + E E+ E R+ + S+ + L++L
Sbjct: 594 LDLLSLKNMSEAQSKN--------EFLSRELIEKERDLERSRTVIAKFQNKLKELVEENK 645
Query: 402 QLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDIN 461
QL K + L+A+ + +K D++ + + + LE +N
Sbjct: 646 QLEEGMK----EILQAIKEM---QKDPDVKGGETSLIIPS--------------LERLVN 684
Query: 462 KITVKTNESIRKKSKY-ESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEME 520
I K E I S + ++++ LT + + L+ KEA K D +E
Sbjct: 685 AIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLE 744
Query: 521 DKIAEVRRKFKGREEFLKKLTQGE----VAAGMVLQKKLYSIYEVQALERKELIKNRAIC 576
K + R+ +G K + + +A ++ + Y I+ +Q LE KE
Sbjct: 745 -KETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKE-------- 795
Query: 577 AMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIF-KDLEATKSKTMIFYAKINELNE 635
L L++ LED + + + S+ + + K+ T+SKT+
Sbjct: 796 -KKLKNLED---SLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTI----------- 840
Query: 636 ELKAKEEEKKSFDQT-LEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFR 694
KEE++K DQ + +K K E+ + + +Q D ++I E+ R
Sbjct: 841 ----KEEKRKLEDQVQQDAIKVK--------EYNNLL--NALQMDSDEMKKILAENSRKI 886
Query: 695 VLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQI 730
+L V +K+L + + LE LR E Q+ ++
Sbjct: 887 TVLQVNEKSLIRQYTTLVE-LERQLRKENEKQKNEL 921
Score = 44.3 bits (103), Expect = 5e-04
Identities = 81/355 (22%), Positives = 143/355 (40%), Gaps = 83/355 (23%)
Query: 154 EKCPELKQEMETLLSEAIRLIKSL--------ETDRADAEEALKQQRSRKNMINMKIDSW 205
EK ++QE E L +E +L L E+ E+ + + + + + D+
Sbjct: 2161 EKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAA 2220
Query: 206 SVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDY 265
L + K + L++ + +Q LE+ +LQ E + +LE A++K I
Sbjct: 2221 E-------KLRIAKNNLEILNEKMTVQ--LEETGKRLQFAESRGPQLEGADSKSWKSIVV 2271
Query: 266 MNEHGPLLD------SKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKA 319
+ L +K+NQ + DLK K+ E K NE+LE
Sbjct: 2272 TRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLE------------- 2318
Query: 320 QQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRET 379
QQIK I K + + +T + KRE+ Q+ L +H + ++E E I +
Sbjct: 2319 QQIK--ILKHVPEGAETEQGLKREL-QVLRLANH-------------QLDKEKAELIHQI 2362
Query: 380 KSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDF 439
+++K++ + S + + DQL K K E Q +++SD+ K
Sbjct: 2363 EANKDQSGAESTIPD-----ADQLKEKIKDLETQ----------------LKMSDLEKQ- 2400
Query: 440 SAISLACTKLTEDNKKLEIDINKITVKTNESIRK-KSKYESEIKYLTIMKLKNDK 493
L E+ KKL+ ++ E I K Y+ E+K +++ K K
Sbjct: 2401 --------HLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKK 2447
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 81.3 bits (199), Expect = 3e-15
Identities = 161/847 (19%), Positives = 330/847 (38%), Gaps = 148/847 (17%)
Query: 105 DVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVK----------EVKPGEKRDE 154
+ E ++ + FE + EE ++T + + E+ VT + E +E
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE 907
Query: 155 KCPEL---KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQ 211
+C +L K ++E + E ++ + + +AE K+++ +K D +
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTE--RAEDEEEINAELTAKKRKLEDECSELKKDIDDL---- 961
Query: 212 ELPLA-VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHG 270
EL LA V+KE A + V L + + K+K L+EA+ + D+ +
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV 1021
Query: 271 PLLDS---KQNQELQDLKNHYKKKMEV-MDLHRKVNEELEEALEACENARLKAQQIKEEI 326
L K Q++ DL+ +++ ++ MDL R +LE L+ + + + + K+++
Sbjct: 1022 NTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLER-AKRKLEGDLKLAQESTMDIENDKQQL 1080
Query: 327 DKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEV-------TEAIRET 379
D+ + + E + + +I +L + + IEE EEE+ +A ++
Sbjct: 1081 DEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1140
Query: 380 KSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAA-----------KKTW 428
EL +S+ LE+ K E ++ + D A +K
Sbjct: 1141 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH 1200
Query: 429 DIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIK----YL 484
++++ + + KL ++ +++++I+ + + K E + L
Sbjct: 1201 ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQL 1260
Query: 485 TIMKLKNDKH---LKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRR---KFKGREEFLK 538
+ +K K ++ + ++ + R+ T + DE + ++++ R F + E LK
Sbjct: 1261 SEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELK 1320
Query: 539 KLTQGEVAAGMVLQKKLYSI--------------------------------------YE 560
+ + E+ A L L S YE
Sbjct: 1321 RQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYE 1380
Query: 561 VQALER-KELIKNRAICAMSLAELQEPL-------LQLEDEAERIRS------LDKEHSV 606
A++R +EL + + A L + +E + LE +R+++ +D E +
Sbjct: 1381 TDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTN 1440
Query: 607 SKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKRE 666
+ +A+ K + K E + EL+A ++E +S L +KN + + E
Sbjct: 1441 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLE 1500
Query: 667 HAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEEN-------- 718
+ + QE D E+I E +R L ++++ Q+ ++ A +LEE
Sbjct: 1501 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQA-ALEEAEASLEHEE 1559
Query: 719 ---LRLAQEYQQLQITF---LKEKD--------NYFNIYDK-QLSLDTSIRDKKQLCQLQ 763
LR+ E Q++ + EKD N+ I + Q +LD IR + +L+
Sbjct: 1560 GKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLK 1619
Query: 764 RRMH------TLWQEHFKLVVLFSQMRLANFQT-------------DSQESIQKILAVQE 804
++M + H + + N Q SQE +++ LA+ E
Sbjct: 1620 KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVE 1679
Query: 805 ESSNLMQ 811
+NL+Q
Sbjct: 1680 RRANLLQ 1686
Score = 64.7 bits (156), Expect = 3e-10
Identities = 119/617 (19%), Positives = 255/617 (41%), Gaps = 72/617 (11%)
Query: 83 RHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETSFEEWS--RTSSTKDLKEDWSVT 140
RH C ++ + + +Q SK + ++ T +E + RT ++ K+ +
Sbjct: 1341 RHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1400
Query: 141 TPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINM 200
E + E + KC L++ + L +E L+ +E A K+QR+ ++
Sbjct: 1401 LQDAE-EHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKIL-- 1457
Query: 201 KIDSWSVWKLQ------ELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEE 254
+ WK + EL A QKE + +++ +++ E+ +QL+ +++ L++
Sbjct: 1458 -----AEWKQKCEETHAELE-ASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQ 1511
Query: 255 ANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACEN 314
+ + I E G K+ EL+ +K +++ + + EE E +LE E
Sbjct: 1512 EISDLTEQIA---EGG-----KRIHELEKIKKQVEQEKSEL---QAALEEAEASLEHEEG 1560
Query: 315 ARLKAQ----QIKEEIDKDIYQDEKTIEAYKRE----IYQLNSLFD---HYSSSVINVNT 363
L+ Q Q+K E+D+ I + ++ I+ KR + + S D + I +
Sbjct: 1561 KILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1620
Query: 364 NIEEKEEEV-----------TEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHEN 412
+E E+ EA+R ++++ L L+D R + L + E
Sbjct: 1621 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVER 1680
Query: 413 Q--YLEA--------VNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINK 462
+ L+A + ++K + EL D ++ + T L KKLE DI++
Sbjct: 1681 RANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ 1740
Query: 463 ITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDK 522
I + + I++ E + K + LK + + + + +++ +
Sbjct: 1741 IQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR 1800
Query: 523 IAEVRR-KFKGREEFLKKL-TQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSL 580
+ E + KG ++ ++KL + G V ++ ++ V+ L + E +
Sbjct: 1801 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHE--RKVKELTYQT 1858
Query: 581 AELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSKTMIFYAKINELNEELKAK 640
E ++ +L+L+D +++++ K + KR A E + ++ + +K + EL+
Sbjct: 1859 EEDRKNILRLQDLVDKLQAKVKSY---KRQA-----EEAEEQSNVNLSKFRRIQHELEEA 1910
Query: 641 EEEKKSFDQTLEILKNK 657
EE + + L+ K
Sbjct: 1911 EERADIAESQVNKLRVK 1927
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 80.9 bits (198), Expect = 5e-15
Identities = 138/612 (22%), Positives = 262/612 (42%), Gaps = 73/612 (11%)
Query: 230 ELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQ---------- 279
+L+ LE +L ++KT L NA ++ + + LL SK ++
Sbjct: 21 DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRIL 80
Query: 280 --ELQDLKNHYKKKMEVMDLHRKVNE-ELEEALEACENARLKAQQI--------KEEIDK 328
EL L+N + KM M ++ E +L+ + E ++ K Q+ KE+ID+
Sbjct: 81 SLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDE 140
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHS 388
+ EK +E Y EI + + Y + + N++EK +E+ +S + +
Sbjct: 141 KS-ETEKLLE-YIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSL---KQSLEENIVI 195
Query: 389 LSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAA----KKTWDIELSDVAKDFSAISL 444
LSK +EDL L +++ H N+ E + A K+ + +E + K L
Sbjct: 196 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREK-LQQKEL 254
Query: 445 ACTKLTEDNKKLEIDIN-KITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAY 503
L + K+L ++ K+ E +++K+ +E E+K T+ +L DK L+ ++A
Sbjct: 255 QIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQ-TLDEL--DK-LQQKEEQAE 310
Query: 504 RIGTLFHLTKHKTDEMEDKIAEVR---RKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYE 560
R L K +E + + E++ K KG+E L+K + A ++LQ+K S+
Sbjct: 311 R------LVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM-- 362
Query: 561 VQALE--RKELIKNRAICAMSLAELQEPLLQLEDEAERI--RSLDKEHSVSKRSAIFKDL 616
VQ+LE + +A+ A + +L+ L+++A + + D +H +
Sbjct: 363 VQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQIL--------- 413
Query: 617 EATKSKTMIFYAKINELNEELKAKEEEKK----SFDQTLEILKNKFITMRFKREHAQTVF 672
AT+S + + +L + KE E K SF Q + L+N+
Sbjct: 414 -ATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 472
Query: 673 DHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITF 732
+ EK++ + EE ++R+L + Q + E L E+ Q
Sbjct: 473 EGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQL 532
Query: 733 LKEKDNYFNIYDKQLSLDTSIRDK-KQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTD 791
K +D+Y + Q +++ K K + +L+ L E KL ++ + + +T
Sbjct: 533 NKIRDSYAKLLGHQ-----NLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQS--ETK 585
Query: 792 SQESIQKILAVQ 803
QE + K+L ++
Sbjct: 586 LQEELNKVLGIK 597
Score = 51.6 bits (122), Expect = 3e-06
Identities = 82/459 (17%), Positives = 187/459 (40%), Gaps = 77/459 (16%)
Query: 103 IQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSV----TTPVKEVKPGEKRDEK--- 155
IQD+E+++++ R + E + S+ E + T + + K E ++K
Sbjct: 19 IQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLR 78
Query: 156 -----CPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSR------------KNMI 198
+L+ + ET + + + +E + +L++ + + K I
Sbjct: 79 ILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKI 138
Query: 199 NMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAK 258
+ K ++ + + E + E Y D+ +L+ +L++K +++ K LEE
Sbjct: 139 DEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSL---KQSLEENIVI 195
Query: 259 IQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLK 318
+ ++ +N LL+ K+K + ++ +R+ NE L ++ + +
Sbjct: 196 LSKQVEDLNVKCQLLE--------------KEKEDHVNRNREHNENLNAEMQNLKQKFIL 241
Query: 319 AQQIKEEIDK------DIYQDEKTIE--------AYKREIYQLNSLFDHYSSSVINVNTN 364
QQ +E++ + + Q EK + +++ E+ + +LF+ ++
Sbjct: 242 EQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 301
Query: 365 IEEKEEEVTEAIR----ETKSSKNELHSLSKM-------LEDLRRVYDQLTWKQKSHENQ 413
+++KEE+ ++ E KS EL L + LE + Q T + +
Sbjct: 302 LQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDS 361
Query: 414 YLEAVND----FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNE 469
++++ D F + K E+ D+ + S++ K ++ + ++ I E
Sbjct: 362 MVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQE 421
Query: 470 SIR-------KKSKYESEIKYLTIMKLKNDKHLKNIYKE 501
+R K + E+EIK +T+ L+ L+N K+
Sbjct: 422 YVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQ 460
Score = 40.4 bits (93), Expect = 0.007
Identities = 76/392 (19%), Positives = 145/392 (36%), Gaps = 94/392 (23%)
Query: 429 DIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMK 488
+ EL + +A T L+ +N LE + ++T +TNE ++ K K L I+
Sbjct: 23 ETELEKMEARLNAALREKTSLSANNATLEKQLIELT-RTNELLKSKFSENGNQKNLRILS 81
Query: 489 LKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAG 548
L+ K L+N + E K+ + K +G E
Sbjct: 82 LELMK-LRN--------------------KRETKMRGMMAKQEGME-------------- 106
Query: 549 MVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSK 608
M LQ S+ E Q +A+L+ L+ +E E +D++ K
Sbjct: 107 MKLQVTQRSLEESQG---------------KIAQLEGKLVSIEKE-----KIDEKSETEK 146
Query: 609 RSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHA 668
+++ + + I +L E LK K +E S Q+LE + + + E
Sbjct: 147 LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLE---ENIVILSKQVEDL 203
Query: 669 QTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQL 728
+EK+D R + E N L E Q L
Sbjct: 204 NVKCQLLEKEKEDHVNR----------------------------NREHNENLNAEMQNL 235
Query: 729 QITFLKEKDNYFNIYDKQLSLDTSIRDKKQL-CQLQRRMHTLWQEHFKLVVLFSQM---- 783
+ F+ E+ + K+L +D+ ++ +K+L L +++ + +E K LF +
Sbjct: 236 KQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQT 295
Query: 784 --RLANFQTDSQESIQKILAVQEESSNLMQHI 813
L Q +++ + + ++EE+ + + +
Sbjct: 296 LDELDKLQQKEEQAERLVKQLEEEAKSRAEEL 327
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 80.5 bits (197), Expect = 6e-15
Identities = 152/739 (20%), Positives = 296/739 (40%), Gaps = 144/739 (19%)
Query: 102 HIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKR----DEKCP 157
H+Q + K+Q++++ E EE L++ VTT K K E++ D+ C
Sbjct: 933 HLQAEKKKMQQNIQELEEQLEEEESARQKLQLEK---VTTEAKLKKLEEEQIILEDQNCK 989
Query: 158 ELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAV 217
K++ LL + I T+ + EE K KN
Sbjct: 990 LAKEKK--LLEDRIA---EFTTNLTEEEEKSKSLAKLKN--------------------- 1023
Query: 218 QKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDS-- 275
+HEA ++D+ E +L+ EKQ+ ELE+ K++ D +++ L +
Sbjct: 1024 --KHEAMITDLEE----------RLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 276 --------KQNQELQDL----------KNHYKKKMEVMDLHRKVNEELEEALEACENARL 317
K+ +ELQ KN KK + +L +++E L+E LE+ +R
Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMALKK--IRELESQISE-LQEDLESERASRN 1128
Query: 318 KAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIR 377
KA++ K ++ +++ EA K E L D S+ + K E+ ++
Sbjct: 1129 KAEKQKRDLGEEL-------EALKTE------LEDTLDSTA--AQQELRSKREQEVNILK 1173
Query: 378 ETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAK 437
+T + + H ++++R+ + Q + Q + AK+T + E ++A
Sbjct: 1174 KTLEEEAKTHEAQ--IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELAN 1231
Query: 438 DFSAISLACTKLTEDNKKLEIDINKITVKTNESIR-------KKSKYESEIKYLTIMKLK 490
+ + KK+E + ++ VK NE R K +K + E+ +T + +
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 491 NDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREE----FLKKLTQGEVA 546
+D + K+ + + T+ E + + K K E+ F ++L + E A
Sbjct: 1292 SDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEA 1351
Query: 547 AGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSV 606
L+K++ +++ Q + K+ +++ C + E++ L + + L + H
Sbjct: 1352 KHN-LEKQIATLH-AQVADMKKKMEDSVGCLETAEEVKRKL------QKDLEGLSQRH-- 1401
Query: 607 SKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKRE 666
++ A + LE TK++ EL++ L + +++S E
Sbjct: 1402 EEKVAAYDKLEKTKTRLQ------QELDDLLVDLDHQRQS---------------ACNLE 1440
Query: 667 HAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQ 726
Q FD + E+K + EE R R R+K + +A +LEE + E +
Sbjct: 1441 KKQKKFDQLLAEEKTISAKYAEE--RDRAEAEAREKETKALS--LARALEEAMEQKAELE 1496
Query: 727 QLQITFLKEKDNYFNIYD-----------KQLSLDTSIRD-KKQLCQLQRRMHTLWQEHF 774
+L F E ++ + D + +L+ + + K QL +L+ +
Sbjct: 1497 RLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKL 1556
Query: 775 KLVVLFSQMRLANFQTDSQ 793
+L V M+ A F+ D Q
Sbjct: 1557 RLEVNLQAMK-AQFERDLQ 1574
Score = 57.4 bits (137), Expect = 5e-08
Identities = 111/561 (19%), Positives = 232/561 (41%), Gaps = 55/561 (9%)
Query: 100 ISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGE----KRDEK 155
+ H + +++ K+F+ E +T S K +E +E + + E+
Sbjct: 1429 LDHQRQSACNLEKKQKKFDQLLAE-EKTISAKYAEERDRAEAEAREKETKALSLARALEE 1487
Query: 156 CPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPL 215
E K E+E L + ++ L + + D +++ + K + +++ +L+EL
Sbjct: 1488 AMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKT-QLEELED 1546
Query: 216 AVQKEHEAYLSDVIELQWHLEDKANQLQ----HFEKQKTELEEANAKIQADIDYMNEHGP 271
+Q +A L + LQ LQ E++K +L +++A+++ +
Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRS 1606
Query: 272 LLDS---KQNQELQDLKNHY----KKKMEVMDLHRKVNEELEEALEACENARLKAQQIKE 324
+ + K +L+DL+ H K + E + RK+ ++++ + ++ R +E
Sbjct: 1607 MAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS----RE 1662
Query: 325 EIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKN 384
EI ++EK +++ + E+ QL ++ +++ +E+ + I + S K
Sbjct: 1663 EILAQAKENEKKLKSMEAEMIQLQEEL----AAAERAKRQAQQERDELADEIANS-SGKG 1717
Query: 385 ELHSLSKMLEDLRRVYDQLTWKQKSHENQY--LEAVNDFYAAKKTWDIELSDVAKDFSAI 442
L LE+ RR+ ++ ++ E + E +ND K ++++ + D +
Sbjct: 1718 AL-----ALEEKRRLEARIAQLEEELEEEQGNTELIND---RLKKANLQIDQINTDLNLE 1769
Query: 443 SLACTKLTEDNKKLEIDINKITVKTNE-SIRKKSKYESEIKYLTIMKLKNDKHLKNIYKE 501
K ++LE ++ VK E KSKY++ I L + ++ L N KE
Sbjct: 1770 RSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKE 1829
Query: 502 AYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEV 561
T+ K ++D + +V + + E++ Q + A+ + Q K
Sbjct: 1830 RQAACKQVRRTEKK---LKDVLLQVDDERRNAEQY---KDQADKASTRLKQLK------- 1876
Query: 562 QALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKS 621
+ LE E RA S +LQ +LED E ++++E S K DL
Sbjct: 1877 RQLEEAEEEAQRA--NASRRKLQR---ELEDATETADAMNREVSSLKNKLRRGDLPFVVP 1931
Query: 622 KTMIFYAKINELNEELKAKEE 642
+ M + +EE+ K +
Sbjct: 1932 RRMARKGAGDGSDEEVDGKAD 1952
Score = 55.5 bits (132), Expect = 2e-07
Identities = 134/632 (21%), Positives = 259/632 (40%), Gaps = 124/632 (19%)
Query: 217 VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTEL---EEANAKIQADIDYMNEHGPLL 273
+Q+ AYL W L K L +Q+ E+ EE K++ L
Sbjct: 812 LQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREK--------QLA 863
Query: 274 DSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACE-NARLKAQQIKEEIDKDIYQ 332
+ E++ L++ E + L ++ E E EA E ARL A+ K+E+++ +
Sbjct: 864 AENRLTEMETLQSQLMA--EKLQLQEQLQAETELCAEAEELRARLTAK--KQELEEICHD 919
Query: 333 DEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKM 392
E +E + H + + NI+E EE+ + E +S++ +L
Sbjct: 920 LEARVEEEEERC-------QHLQAEKKKMQQNIQELEEQ----LEEEESARQKL------ 962
Query: 393 LEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTED 452
L +V + K+ E LE N A +K L D +F+ T LTE+
Sbjct: 963 --QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL---LEDRIAEFT------TNLTEE 1011
Query: 453 NKKLEIDINKITVKTNESIRK-KSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHL 511
+K ++S+ K K+K+E+ I L + +K + + K ++
Sbjct: 1012 EEK------------SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTD 1059
Query: 512 TKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIK 571
+ E++ +IAE++ + +EE LQ L + E A + L K
Sbjct: 1060 LSDQIAELQAQIAELKMQLAKKEE--------------ELQAALARVEEEAAQKNMALKK 1105
Query: 572 NRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSKTMIFYAKIN 631
R EL+ + +L+++ E R+ + KR + ++LEA K+ ++
Sbjct: 1106 IR--------ELESQISELQEDLESERASRNKAEKQKRD-LGEELEALKT-------ELE 1149
Query: 632 ELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHA--QTVFDHYMQEKKDCEERIFEE 689
+ + A++E + +Q + ILK K + K A Q + + Q ++ E++ E+
Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILK-KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQL-EQ 1207
Query: 690 DQRFRVLLAVRQKTLQDTQKIIA-----------DSLEENLRLAQEYQQLQITFLKEKDN 738
+R + L ++TL++ + +A DS + ++ + Q+LQ+ F + +
Sbjct: 1208 TKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERV 1267
Query: 739 YFNIYDK----QLSLDT-----SIRDKKQL----------CQLQRRMHTLWQEHFKLVVL 779
+ DK Q+ LD S D K QLQ L +E+ + + L
Sbjct: 1268 RTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL 1327
Query: 780 FSQMRLANFQTDSQESIQKILAVQEESSNLMQ 811
++++ D + S ++ L +EE+ + ++
Sbjct: 1328 STKLKQVE---DEKNSFREQLEEEEEAKHNLE 1356
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 80.5 bits (197), Expect = 6e-15
Identities = 140/697 (20%), Positives = 294/697 (42%), Gaps = 121/697 (17%)
Query: 142 PVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMK 201
PV E K E + + E LL I+S +E S K + +
Sbjct: 270 PVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQS-------HKEQCTLLTSEKEALQEQ 322
Query: 202 IDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQK-TELEEANAKIQ 260
+D +LQEL +K + ++++ +L L D N ++ E+ K + E ++
Sbjct: 323 LDE----RLQEL----EKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMH 374
Query: 261 ADIDYMNEHGPLLDSK------QNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACEN 314
++ E L S+ Q +EL++ K+K E R EELE+AL +
Sbjct: 375 ETLEMKEEEIAQLRSRIKQMTTQGEELRE----QKEKSE-----RAAFEELEKALSTAQK 425
Query: 315 ARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTE 374
+++K E+D+ I EKT E + I++ + ++EV +
Sbjct: 426 TEEARRKLKAEMDEQIKTIEKTSEEER-----------------ISLQQELSRVKQEVVD 468
Query: 375 AIRETKSSKNELHSLSKMLE-DLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELS 433
++ KSS+ ++ L K+ E +L R +LT K ++ E ++ E + ++ +++S
Sbjct: 469 VMK--KSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS 526
Query: 434 DVAKDFSAISLACTK------LTEDNKKL-----EIDINKITVKTNESIRKKSKYE--SE 480
+ +++L + LTE KL E + + + ES +KS E ++
Sbjct: 527 QEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQ 586
Query: 481 IKYLTI-MKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEM-EDKIAEVRRKFKGREEFLK 538
K L + ++ + +KH K I + T KH+ D + +K+ ++++++ E L+
Sbjct: 587 SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR 646
Query: 539 KLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMS-LAELQEPLLQLEDEAERI 597
+ + E++ L+K++ I + + E+ E L+ D +
Sbjct: 647 EKCE---------------------QEKETLLKDKEIIFQAHIEEMNEKTLEKLD----V 681
Query: 598 RSLDKEHSVSKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNK 657
+ + E S+ S + K + + + + +++ +EL+AK +E+K+ Q
Sbjct: 682 KQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQ-------- 733
Query: 658 FITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEE 717
+ ++ + + E+ + ++ + +LL R K L++ Q + ++LE
Sbjct: 734 --------QQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHV-ENLEA 784
Query: 718 NLRLAQ-EYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKL 776
+++ ++ E QQ K + F Y T + +QL QLQ+++ L E L
Sbjct: 785 DIKRSEGELQQ-----ASAKLDVFQSYQSATHEQTKAYE-EQLAQLQQKLLDLETERILL 838
Query: 777 VVLFSQMRLANFQTDSQESIQKILAVQEESSNLMQHI 813
++A + ++ ++ A + + +LMQ +
Sbjct: 839 T-----KQVAEVEAQKKDVCTELDAHKIQVQDLMQQL 870
Score = 72.0 bits (175), Expect = 2e-12
Identities = 149/808 (18%), Positives = 318/808 (39%), Gaps = 152/808 (18%)
Query: 100 ISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKE----DWSVTTPVKEVKPGEKRDEK 155
+S + K++E L + ++ + K ++ V + +KE + +R EK
Sbjct: 693 LSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEK 752
Query: 156 C-PELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWK----- 209
+ ++E LL E + +K + + E +K+ + K+D + ++
Sbjct: 753 ALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHE 812
Query: 210 -----------LQELPLAVQKEHEAYLSDVIELQWHLEDKANQL-----------QHFEK 247
LQ+ L ++ E V E++ +D +L Q EK
Sbjct: 813 QTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEK 872
Query: 248 QKTELEEA--------NAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVM---- 295
Q +E+E+ +K++ + +L K+N LQ ++ KK++E++
Sbjct: 873 QNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQ-MREGQKKEIEILTQKL 931
Query: 296 ----DLHRKVNEELEEAL----EACENARLKAQQIKEEIDK------------------D 329
D +NEE E + E + KA++++E + K +
Sbjct: 932 SAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALE 991
Query: 330 IYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNEL--H 387
+ Q EK A E+ Q NS S +V + TN +E+ E +TE R + +
Sbjct: 992 LSQKEKQFNAKMLEMAQANSA--GISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEK 1049
Query: 388 SLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKK-------TW--------DIEL 432
L++ E+L+ ++ ++ ++K E L+ + +K TW D L
Sbjct: 1050 KLNQQAEELQEIH-EIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTL 1108
Query: 433 SDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKND 492
+++ + S L +D KL+ + K+ V N+S+++ + + ++ L ++
Sbjct: 1109 NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKML----- 1163
Query: 493 KHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQ 552
+E + K++E+ K K +E + L + L+
Sbjct: 1164 -----------------------AEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLE 1200
Query: 553 KKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLE-DEAERIRSLDKEHSVSKRSA 611
K +LE K+L + AI + E LL+ + +E I S +S+ S
Sbjct: 1201 DK--------SLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISH 1252
Query: 612 IFKDLEATKSKTMIFYAKINELNEELKAKEEEKK----SFDQTLEILKNKFITMRFKREH 667
K +I ++EL +L+ EE+ SF Q L+ K ++ +
Sbjct: 1253 CQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKAD 1312
Query: 668 AQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQ 727
+++ +E + +E + + ++ + +K +++++ + +E
Sbjct: 1313 IESLVTE--------KEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEE--- 1361
Query: 728 LQITFLKEKDNYFNIYDKQLS-LDTSIRDKKQLCQLQRRMHTLWQEH-FKLVVLFSQMRL 785
LKEK + KQL+ L+ +++ L + + + +L +++ + L Q++
Sbjct: 1362 -----LKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQD 1416
Query: 786 ANFQTD--SQESIQKILAVQEESSNLMQ 811
+F+ D S+E I + V + S+ +
Sbjct: 1417 LSFKVDTLSKEKISALEQVDDWSNKFSE 1444
Score = 62.4 bits (150), Expect = 2e-09
Identities = 144/754 (19%), Positives = 292/754 (38%), Gaps = 131/754 (17%)
Query: 161 QEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKE 220
Q T + EA+ LIK+ +A+ L+Q +N +N+ + +L+E ++
Sbjct: 1254 QHRTTKVKEAL-LIKTCTVSELEAQ--LRQLTEEQNTLNISFQQ-ATHQLEEKENQIKSM 1309
Query: 221 HEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQ--- 277
S V E + ++ NQ Q ++++ + + ++ +I+ + L K+
Sbjct: 1310 KADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEI 1369
Query: 278 ----------NQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIK---- 323
N +LQ+ + +K+ + L ++ +EE E L+ ++ K +
Sbjct: 1370 SSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKI 1429
Query: 324 ---EEID-----------------------------------KDIYQDEKTIEAYKREIY 345
E++D K+ Y+ ++ I K E+
Sbjct: 1430 SALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELD 1489
Query: 346 QLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNEL--HSLSKM--LEDLRRVYD 401
Q N FD + + + +E+KE + ++ + EL H K +E L V
Sbjct: 1490 QQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLK 1549
Query: 402 QLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAI--SLACTKLTEDNKKLEID 459
++ + ++ + F + D + + + + + K + KK E++
Sbjct: 1550 NYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELE 1609
Query: 460 INKITVKTNESIRK--KSKYESE-IKYLTIMKLKNDKHLKNIYK----------EAYRIG 506
++VK+ E K + + ESE L +K K ++ + I K E Y+ G
Sbjct: 1610 HVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKG 1669
Query: 507 TLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQK-KLYSIY------ 559
T HL+ E+ K+ E R+ EE LK + + +V + K + Y
Sbjct: 1670 TESHLS-----ELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEA 1724
Query: 560 EVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEAT 619
+ Q +K + ++ +L E ++ L ++ E E S E + + K LE
Sbjct: 1725 DSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIK-LEHA 1783
Query: 620 KSKTMIFYAKINELNEEL------------------------KAKEEEKKSFDQTLEILK 655
++K + I L EEL +AK+ + FD + L+
Sbjct: 1784 EAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQ 1843
Query: 656 NKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSL 715
K +T + + + + +++K+ + E ++ L A++Q D + + L
Sbjct: 1844 EKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQ---MDGRNKPTELL 1900
Query: 716 EENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDK----KQLCQLQRRMHTLWQ 771
EEN + +Q L + N D + L + R+K K++ +LQ+ + L +
Sbjct: 1901 EENTEEKSKSHLVQPKLLSNMEAQHN--DLEFKLAGAEREKQKLGKEIVRLQKDLRMLRK 1958
Query: 772 EHFKLVVLFSQMRLANFQTDSQESIQKILAVQEE 805
EH + ++ + + D QE +KI QE+
Sbjct: 1959 EHQQ------ELEILKKEYD-QEREEKIKQEQED 1985
Score = 62.0 bits (149), Expect = 2e-09
Identities = 125/643 (19%), Positives = 260/643 (40%), Gaps = 83/643 (12%)
Query: 101 SHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELK 160
+ I ++E I + E+ E + KD++ V + GE++D + E +
Sbjct: 1525 ARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAE 1584
Query: 161 QEMETLLSEAIRLIKSLETDRADAEE---ALKQQRSRKNMINMKIDSWSVWKLQELPLAV 217
+++ TL ++ + LET + + E ++K + + +++S S KL EL
Sbjct: 1585 EKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKA 1644
Query: 218 QKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQ---ADIDYMNEHGPLLD 274
+++ A ++ +E+K Q + + ++ L E N K+Q ++ + E ++
Sbjct: 1645 EQKIAAIKKQLLS---QMEEKEEQYK--KGTESHLSELNTKLQEREREVHILEEKLKSVE 1699
Query: 275 SKQNQEL---QDLKN------------------HYKKKMEVMD--------LHRKVNEEL 305
S Q++ L + KN Y++K+ V+ L ++V +E
Sbjct: 1700 SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEK 1759
Query: 306 EEALEACENARLKAQQ--IK-EEIDKDIYQDEKTIEAYKREIYQLNSLFD---------H 353
EE + + R + Q+ IK E + ++D+ I + E+ + N +
Sbjct: 1760 EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKE 1819
Query: 354 YSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDL---RRVYDQLTWKQKSH 410
+ I N+E ++V + ++E + + L K L+ ++ ++ ++ +
Sbjct: 1820 GGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTS 1879
Query: 411 ENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNES 470
+ + L+A+ K ++ L + ++ S L KL + +E N + K +
Sbjct: 1880 KYEKLQALQQMDGRNKPTEL-LEENTEEKSKSHLVQPKLLSN---MEAQHNDLEFKLAGA 1935
Query: 471 IRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKF 530
R+K K EI ++ K L+ + KE + L L K E E+KI + +
Sbjct: 1936 EREKQKLGKEI-------VRLQKDLRMLRKEHQQ--ELEILKKEYDQEREEKIKQEQEDL 1986
Query: 531 KGR---------EEFLKKLTQGEVAAGMVLQKKLYSIYEVQA--LERKELIKNRAICAMS 579
+ + EF +L Q E M +++ + EV+A LE + N+ +
Sbjct: 1987 ELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLL--KK 2044
Query: 580 LAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSK-TMIFYAKINELNEELK 638
+AE + L + E I +E +K + LE + K + N N+ +
Sbjct: 2045 IAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVT 2104
Query: 639 AKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKD 681
E + + +T I +K F RE + D + +K+
Sbjct: 2105 IMELQTQLAQKTTLISDSKLKEQEF-REQIHNLEDRLKKYEKN 2146
Score = 60.8 bits (146), Expect = 5e-09
Identities = 153/804 (19%), Positives = 328/804 (40%), Gaps = 68/804 (8%)
Query: 24 QEVKALREKAWSRTNEGNAMSQSLVLYGASKENSEGFHESKMTNTEGVNKGIYF---SYP 80
Q+VK+L + S+ +GN + KEN + EG K I
Sbjct: 879 QKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMI------LQMREGQKKEIEILTQKLS 932
Query: 81 CRRHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVT 140
+ S ++N + + ++ E K+++ ++ + E + ++ K +
Sbjct: 933 AKEDSIHILN------EEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELE 986
Query: 141 TPVKEVKPGEKR-DEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMIN 199
E+ EK+ + K E+ Q +S+A+ LET++ + E+L + R+ +N
Sbjct: 987 NTALELSQKEKQFNAKMLEMAQANSAGISDAV---SRLETNQKEQIESLTEVHRRE--LN 1041
Query: 200 MKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKI 259
I W KL + +Q+ HE I+LQ ++ A Q E EE N
Sbjct: 1042 DVISIWEK-KLNQQAEELQEIHE------IQLQEKEQEVAELKQKILLFGCEKEEMNK-- 1092
Query: 260 QADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKA 319
+I ++ E G KQ+ L +L+ K+K ++ + +L+ LE E K+
Sbjct: 1093 --EITWLKEEGV----KQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKS 1146
Query: 320 QQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRET 379
+ + + + + + E KR++ +L S ++ ++ E+ + + + E
Sbjct: 1147 LKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEF 1206
Query: 380 KSSKNELH-----SLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSD 434
K EL K L ++L S N L ++ + +T ++ +
Sbjct: 1207 KKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRIS--HCQHRTTKVKEAL 1264
Query: 435 VAK--DFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKND 492
+ K S + +LTE+ L I + T + E + +++I+ L K
Sbjct: 1265 LIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQ 1324
Query: 493 KHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQ 552
K N + A + K + E + + ++ + K ++ + L++ + LQ
Sbjct: 1325 KEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQ 1384
Query: 553 KKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLED-EAERIRSLDKEHSVSKRSA 611
+ + A+ + C + L ++Q+ +++ E+I +L++ S + +
Sbjct: 1385 NSISLSEKEAAISSLRKQYDEEKCEL-LDQVQDLSFKVDTLSKEKISALEQVDDWSNKFS 1443
Query: 612 IFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTV 671
+K + +S+ + EL +L+ K +E D+ + +LK + + + KR
Sbjct: 1444 EWK--KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEE-LDQQNKR------ 1494
Query: 672 FDHYMQEKKDCEERIFEEDQRFRVLL---AVRQKTLQD--TQKII-ADSLEENLRLAQEY 725
FD E +D + ++ +++ L R L+D TQK I +SL E L+ +
Sbjct: 1495 FDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQ 1554
Query: 726 QQLQITFLKEKDNYFNIYDKQLSLDTSIRD-KKQLCQLQRRMHTLWQEHFKLVVLFSQMR 784
+ ++ L +K +F ++ D +++ ++++ L+ +++++ E L ++
Sbjct: 1555 KDIEHKELVQKLQHFQELGEE--KDNRVKEAEEKILTLENQVYSMKAE---LETKKKELE 1609
Query: 785 LANFQTDSQESIQKILAVQEESSN 808
N S+E K L + ES +
Sbjct: 1610 HVNLSVKSKEEELKALEDRLESES 1633
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 80.1 bits (196), Expect = 8e-15
Identities = 131/661 (19%), Positives = 272/661 (41%), Gaps = 84/661 (12%)
Query: 102 HIQDVESKIQEHLKRFETSFEEWSRT-SSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELK 160
H+ +ES +++ K EE R + D + ++ T + E +D K ++
Sbjct: 342 HVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVI------EMKDSKISSME 395
Query: 161 QEMETLLSEAIRLIKS---LETDRADAEEALKQQ---RSRKNMINMKIDSWSVWKLQELP 214
+ + L E I+++KS L T+ + EE +KQ RS + KI
Sbjct: 396 RGLRDL-EEEIQMLKSNGALSTE--EREEEMKQMEVYRSHSKFMKNKIGQ---------- 442
Query: 215 LAVQKEHEAYLSDVIELQWHLEDKANQL----QHFEKQKTEL---EEANAKIQADIDYMN 267
V++E ++++ LQ LE NQ QH E K L E+ A +Q ++D +
Sbjct: 443 --VKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALR 500
Query: 268 ---EHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKE 324
E + +K+ +++QD+ +K + ++H +L++ L+ E Q+ E
Sbjct: 501 LRLEEKETMLNKKTKQIQDMAE--EKGTQAGEIH-----DLKDMLDVKERKVNVLQKKIE 553
Query: 325 EIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVT----EAIRETK 380
+ + + EK + + K + L + + +++ + + EKE + + R+ +
Sbjct: 554 NLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDER 613
Query: 381 SSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKD-- 438
+ E+ + K L+DL+ L E L+ + + S + KD
Sbjct: 614 EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDL------KEHASSLASSGLKKDSR 667
Query: 439 FSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNI 498
+ +A + E+ K+E + K E+ R + I++L +
Sbjct: 668 LKTLEIALEQKKEECLKMESQLKKAHEAALEA-RASPEMSDRIQHLEREITRYKDESSKA 726
Query: 499 YKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSI 558
E R+ + +++ ++ + KIAE+ R+ K + + + L E V +KK +
Sbjct: 727 QAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKE----QVEKKKSAQM 782
Query: 559 YEVQALERKELIKNRAICAMSLAELQEPLLQLEDE--------AERIRSLDKEHSVSKRS 610
E L + SL + + + +LE+ AER L +E S +
Sbjct: 783 LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA 842
Query: 611 A-----IFKDLEATKSKTMIFYAKINELNEELKAKE--------EEKKSFDQTLEILKNK 657
+ +E K + AK++ + L KE E +K ++ LE+ +
Sbjct: 843 EKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEA 902
Query: 658 FITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEE 717
+ +++ + + +KK EE + ++ R++ ++Q+T Q+ K++AD+ E+
Sbjct: 903 LLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQT-QNRMKLMADNYED 961
Query: 718 N 718
+
Sbjct: 962 D 962
Score = 64.3 bits (155), Expect = 4e-10
Identities = 93/451 (20%), Positives = 203/451 (45%), Gaps = 63/451 (13%)
Query: 89 VNIPAPCVNKMISHIQDVE---SKIQEHLKRFE--TSFEEWSRTSSTKDLKEDWSVTTPV 143
VN+ + + ++D E S ++E +K + T+ + + T+ + L E +
Sbjct: 545 VNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERL 604
Query: 144 KEVKPGEKRD--EKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMK 201
KE + ++R+ E+ K++++ L E + L++ +++ + LK+ S +K
Sbjct: 605 KEQRDRDEREKQEEIDNYKKDLKDL-KEKVSLLQGDLSEKEASLLDLKEHASSLASSGLK 663
Query: 202 IDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLE---------DKANQLQHFEKQKTEL 252
DS +L+ L +A++++ E L +L+ E + ++++QH E++ T
Sbjct: 664 KDS----RLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRY 719
Query: 253 EEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKV----------- 301
++ ++K QA++D + E +L +N++ K + + +V D ++KV
Sbjct: 720 KDESSKAQAEVDRLLE---ILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEK 776
Query: 302 ---NEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSV 358
+ LEEA +N +QQ+++ + K + E+ EA RE Q+ + + +
Sbjct: 777 KKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEAL-RESVQITAEREMVLAQE 835
Query: 359 INVNTNIEEKEEEVTEAI----RETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQY 414
+ TN E++ EE+ A+ +E +S K +L S + L + L +++ H +
Sbjct: 836 ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEV 895
Query: 415 LEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKK 474
LE + A A ++A +L+ KK + ++ + R+K
Sbjct: 896 LEMKQEALLA-----------AISEKDANIALLELSSSKKKTQEEVAALK-------REK 937
Query: 475 SKYESEIKYLT--IMKLKNDKHLKNIYKEAY 503
+ ++K T MKL D + + +K ++
Sbjct: 938 DRLVQQLKQQTQNRMKLMADNYEDDHFKSSH 968
Score = 58.5 bits (140), Expect = 2e-08
Identities = 93/466 (19%), Positives = 194/466 (41%), Gaps = 74/466 (15%)
Query: 348 NSLFDHYSSSVINVNTNIEE--KEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTW 405
+SL ++++++ T ++E +E ++ E K SK LS + ++ +
Sbjct: 141 HSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESK-----LSSSMNSIKTFWSPELK 195
Query: 406 KQKSHENQYLEAVNDFYAAKKT-WDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKIT 464
K++ A+ A+K T W + V ++ + + L +D +++ D+N++
Sbjct: 196 KER--------ALRKDEASKITIWKEQYRVVQEENQHMQMTIQAL-QDELRIQRDLNQL- 245
Query: 465 VKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIA 524
+ + S R +E+ +++ + ++ E R L + +EME +I
Sbjct: 246 FQQDSSSRTGEPCVAEL---------TEENFQRLHAEHERQAKELFLLRKTLEEMELRIE 296
Query: 525 EVRRKFKGREEFLKKLTQGEVAAGM--------------VLQKKLYSIYEVQALERKEL- 569
++ R+E +KKL + + G+ + + +++ + LE+KE
Sbjct: 297 TQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKE 356
Query: 570 ------------------IKNRAICAM------SLAELQEPLLQLEDEAERIRSLDKEHS 605
K +A+ + ++ ++ L LE+E + ++S + S
Sbjct: 357 NSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKS-NGALS 415
Query: 606 VSKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKR 665
+R K +E +S + KI ++ +EL K+ E + LE L N+F +
Sbjct: 416 TEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSD---SK 472
Query: 666 EHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEY 725
+H + V + K+ + E R+ L ++ L K I D EE A E
Sbjct: 473 QHIE-VLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 531
Query: 726 QQLQITFLKEKDNYFNIYDKQL-SLDTSIRDK-KQLCQLQRRMHTL 769
L+ L K+ N+ K++ +L +RDK KQ+ L+ R+ +L
Sbjct: 532 HDLK-DMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSL 576
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 80.1 bits (196), Expect = 8e-15
Identities = 131/675 (19%), Positives = 278/675 (41%), Gaps = 71/675 (10%)
Query: 158 ELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAV 217
EL+Q++E L EA RL + + + A Q+ ++ +++ + +LQE+ + +
Sbjct: 474 ELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERE--RLQEMLMGL 531
Query: 218 QKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQ 277
+ + LS++I L+ LE + + +++TE+ A A+ + I ++ L +
Sbjct: 532 EAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKT-- 589
Query: 278 NQELQDLKNHYKK--------KMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKD 329
E+ DL+ K ++ + L++++ + EE C A+Q + + D
Sbjct: 590 --EVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA-AEQARNALQVD 646
Query: 330 IYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSL 389
+ + EK EA + L + + + ++ + +EE E ++ S+++ +
Sbjct: 647 LAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAA 706
Query: 390 SKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYA---AKKTWDIELSDVAKDFSAISLAC 446
+ LE QL + K E AV + A K ++ L V +D ++
Sbjct: 707 TTQLE-------QLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQL 759
Query: 447 TKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIG 506
L+ + LE + + S+ + +K + E++ T+ + K + + R
Sbjct: 760 QGLSSAKELLESSL--FEAQQQNSVIEVTKGQLEVQIQTVTQ------AKEVIQGEVRCL 811
Query: 507 TLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALER 566
L L ++ +++ A R+ + +E L Q + A + + + ++ +
Sbjct: 812 KL-ELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQ 870
Query: 567 KELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFK-DLEATKSKTMI 625
+EL K EL+ L + + E E I++ +E SA+ + LE K + +
Sbjct: 871 QELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSL 930
Query: 626 FYAKINELNEELKAKEE-EKKSFDQTLEILKNKFIT--MRFKREHAQTVFDHYMQEKKDC 682
+ E A ++ E+ D ++ LK + T ++ + + AQ ++ +D
Sbjct: 931 LETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDD 990
Query: 683 EERIFEEDQRFRVLLAVRQKTLQ----------DTQKIIADSLEENLRLAQEYQQLQITF 732
+ EE QK ++ D+Q+++ ++E LR QEY ++Q
Sbjct: 991 LAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKEL 1050
Query: 733 LKEKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDS 792
+EK SL S+ +K+Q + + ++ Q L+ + D
Sbjct: 1051 EREK----------ASLTLSLMEKEQRLLVLQEADSI-----------RQQELSALRQDM 1089
Query: 793 QES--IQKILAVQEE 805
QE+ QK L+ Q E
Sbjct: 1090 QEAQGEQKELSAQME 1104
Score = 65.5 bits (158), Expect = 2e-10
Identities = 140/698 (20%), Positives = 277/698 (39%), Gaps = 135/698 (19%)
Query: 169 EAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDV 228
+A+ L++S+ T R A + L+QQ + QE +Q++H+
Sbjct: 386 KALTLVRSVLTRRRQAVQDLRQQLAG---------------CQEAVNLLQQQHD------ 424
Query: 229 IELQWHLEDKA--NQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKN 286
QW E KA +LQ ++ L +Q ++D +++ LL
Sbjct: 425 ---QWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELL------------- 468
Query: 287 HYKKKMEVMDLHRKVNEELEEALEACE---------NARLKAQQIKEEIDKDIYQDEKTI 337
+K EEL + LE E N L+ Q + K+ Q+E +
Sbjct: 469 ------------QKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHL 516
Query: 338 EAYKREIYQ-----LNSLFDHYSSSVINVNTNIE----------EKEEEVTEAIRETKSS 382
+RE Q L + S +I + +E +++ EVT A+ + S
Sbjct: 517 AVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQS 576
Query: 383 KNELHSLSKMLE----DLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKT-WDIELSDVAK 437
EL S L+ DLR +L+ A+N+ A K + +L + +
Sbjct: 577 IAELSSSENTLKTEVADLRAAAVKLS------------ALNEALALDKVGLNQQLLQLEE 624
Query: 438 DFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKN 497
+ ++ + L++D+ + + K + E++++ + L++
Sbjct: 625 ENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRD 684
Query: 498 IYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYS 557
I +E I ++H+ + ++ ++ ++ K +EE L + Q + A ++++K
Sbjct: 685 IQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEA---LVREKAAL 741
Query: 558 IYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLE 617
+QA+ER +R A L L LE + + V+K +
Sbjct: 742 EVRLQAVER-----DRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQT 796
Query: 618 ATKSKTMIFYAKIN----ELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFD 673
T++K +I ++ EL+ E E+E+ + + L + + T +++ A
Sbjct: 797 VTQAKEVI-QGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEV 855
Query: 674 HYMQEKKDCEE--------RIFEEDQRFRVLLAVRQKTLQ-DTQKIIADSLEENLRLAQE 724
+ ++EK + E + E +R ++ L +R K Q + + I A EE +
Sbjct: 856 NQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESA 915
Query: 725 YQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMR 784
Q+Q+ KE+ + L+T ++ +K+L +++ L Q+ K+ L Q
Sbjct: 916 LCQMQLETEKERVSL---------LETLLQTQKELADASQQLERLRQD-MKVQKLKEQET 965
Query: 785 LANFQTDSQESIQK-----------ILAVQEESSNLMQ 811
QT QE+ ++ + A+QEESS+L+Q
Sbjct: 966 TGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003
Score = 64.7 bits (156), Expect = 3e-10
Identities = 127/706 (17%), Positives = 289/706 (40%), Gaps = 81/706 (11%)
Query: 158 ELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWK-----LQE 212
E ++E+ETL + L K E +A E + R ++++ + + L+
Sbjct: 1432 EREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEH 1491
Query: 213 LPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPL 272
LP+AVQ+ + +++ +D+ Q E Q ELE+ + I++ + +
Sbjct: 1492 LPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQ 1551
Query: 273 LDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQ 332
L + + L+ +NH+K M+ +K+ +ELE E A + D+ +
Sbjct: 1552 LVTLECLALELEENHHK-----MECQQKLIKELEGQRETQRVA-------LTHLTLDLEE 1599
Query: 333 DEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKM 392
+ ++A +I+ L S + + + ++ + E++ E R+ + +L +
Sbjct: 1600 RSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQE 1659
Query: 393 LEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTED 452
L L++ Q+ Q++ + + LE D K + L + ++ + + E+
Sbjct: 1660 LM-LQKERIQVLEDQRTRQTKILE--EDLEQIK----LSLRERGRELTTQRQLMQERAEE 1712
Query: 453 NK------KLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIG 506
K + ++ K+ ++ E ++ + I L +K + ++ L+ ++++
Sbjct: 1713 GKGPSKAQRGSLEHMKLILRDKE--KEVECQQEHIHELQELKDQLEQQLQGLHRKVGETS 1770
Query: 507 TLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIY--EVQAL 564
L + + ++ ++ E R + + +E+ L+ A ++L ++ + QA
Sbjct: 1771 LLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQ 1830
Query: 565 ERKELIKNRAICAMSLAE-----LQEPLLQLEDEAERIRSLDKEHSVSKR-----SAIFK 614
++E +K +A E L+E +L+D E+ R L++E +V R +
Sbjct: 1831 GQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLG 1890
Query: 615 DLEA-TKSKTMIFYAKINELNEELKAKEEEKKSF--------------DQTLEILKNKFI 659
DL A ++ + A + E+ + E E ++ DQ LE L+ +
Sbjct: 1891 DLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQ 1950
Query: 660 TMRFKREHA-------QTVFDHYMQEKKDCEERIFEEDQRFRVLLA-------------V 699
+ R + E A Q + E+ + E+ + R L A
Sbjct: 1951 SSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQA 2010
Query: 700 RQKTLQDTQKIIADSL-EENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKKQ 758
+ L++ +I + +++LR ++ QQLQ + + + +++ L+ S+ + Q
Sbjct: 2011 HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQ 2070
Query: 759 LCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAVQE 804
+Q + + L QE + + + Q + Q+IL ++E
Sbjct: 2071 ENMIQEKQN-LGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRE 2115
Score = 45.1 bits (105), Expect = 3e-04
Identities = 113/569 (19%), Positives = 222/569 (39%), Gaps = 70/569 (12%)
Query: 222 EAYLSD-VIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQE 280
+A L D V EL L Q + +EK L E ++ + + EH L +E
Sbjct: 278 KAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEE 337
Query: 281 LQDLKNHYKKKMEVM---DLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTI 337
L+ K +VM + E +LE ++ + +Q ++ DK + +
Sbjct: 338 KLSLQQVIKDITQVMVEEGDNIAQGSGHENSLEL--DSSIFSQFDYQDADKALTLVRSVL 395
Query: 338 EAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLR 397
++ + L +V + ++ EEE + + E +L+ DL+
Sbjct: 396 TRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQ 455
Query: 398 RVYDQLTWK----QKSHE--NQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTE 451
D L+ + QK+ E Q LE + ++ W + +V S K E
Sbjct: 456 GEVDSLSKERELLQKAREELRQQLEVLE-----QEAWRLRRVNVELQLQGDSAQGQK-EE 509
Query: 452 DNKKLEIDINKITVKTNESIR--KKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLF 509
++L + + + + E + + + ES + +T+ + HL+
Sbjct: 510 QQEELHLAVRE-RERLQEMLMGLEAKQSESLSELITLREALESSHLEG------------ 556
Query: 510 HLTKHKTDEMEDKIAEVRR---KFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALER 566
L + + E+ +A + + E LK EVA KL ++ E AL++
Sbjct: 557 ELLRQEQTEVTAALARAEQSIAELSSSENTLKT----EVADLRAAAVKLSALNEALALDK 612
Query: 567 KELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSKTMIF 626
L + LLQLE+E + + S E + R+A+ DL + +
Sbjct: 613 --------------VGLNQQLLQLEEENQSVCS-RMEAAEQARNALQVDLAEAEKRREAL 657
Query: 627 YAKINELNEELKAKEE-------EKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEK 679
+ K L +L+ EE + + + E ++ K R ++E A T + QE
Sbjct: 658 WEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEA 717
Query: 680 KDCEE---RIFEEDQ---RFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFL 733
K EE R +E + R + L VR + ++ ++ +A+ L + L A+E + +
Sbjct: 718 KRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQL-QGLSSAKELLESSLFEA 776
Query: 734 KEKDNYFNIYDKQLSLD-TSIRDKKQLCQ 761
+++++ + QL + ++ K++ Q
Sbjct: 777 QQQNSVIEVTKGQLEVQIQTVTQAKEVIQ 805
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 80.1 bits (196), Expect = 8e-15
Identities = 167/846 (19%), Positives = 333/846 (39%), Gaps = 142/846 (16%)
Query: 98 KMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPG-EKRDEKC 156
K ++ +++ KI++ L + E +E T LKE + V+ G +E+C
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTL-LKEKNDLQLQVQAEAEGLADAEERC 911
Query: 157 PEL---KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQEL 213
+L K ++E + E ++ + + +AE K+++ +K D + EL
Sbjct: 912 DQLIKTKIQLEAKIKEVTE--RAEDEEEINAELTAKKRKLEDECSELKKDIDDL----EL 965
Query: 214 PLA-VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPL 272
LA V+KE A + V L + + K+K L+EA+ + D+ +
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 273 LDS---KQNQELQDLKNHYKKKMEV-MDLHRKVNEELEEALEACENARLKAQQIKEEIDK 328
L K Q++ DL+ +++ ++ MDL R +LE L+ + + + + K+++D+
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLER-AKRKLEGDLKLAQESIMDIENEKQQLDE 1084
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEV-------TEAIRETKS 381
+ + E I + +I +L + + IEE EEE+ +A ++
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1144
Query: 382 SKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAA-----------KKTWDI 430
EL +S+ LE+ K E ++ + D A +K
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Query: 431 ELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIK----YLTI 486
++++ + + KL ++ +++++I+ + + K E + L+
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSE 1264
Query: 487 MKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEF------LKKL 540
+K K ++ + I + G L + + ++++K A V + +G++ F LK+
Sbjct: 1265 LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ 1324
Query: 541 TQGEVAAGMVLQKKLYSI--------------------------------------YEVQ 562
+ E+ A L L S YE
Sbjct: 1325 LEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETD 1384
Query: 563 ALER-KELIKNRAICAMSL--------------AELQEPLLQLEDEAERIRSLDKEHSVS 607
A++R +EL + + A L A L++ +L++E E + LD E + +
Sbjct: 1385 AIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL-MLDVERTNA 1443
Query: 608 KRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREH 667
+A+ K + K E + EL+A ++E +S L +KN + + E
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLET 1503
Query: 668 AQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEEN--------- 718
+ + QE D E+I E +R L ++++ Q+ ++ A +LEE
Sbjct: 1504 LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA-ALEEAEASLEHEEG 1562
Query: 719 --LRLAQEYQQLQITF---LKEKD--------NYFNIYDK-QLSLDTSIRDKKQLCQLQR 764
LR+ E Q++ + EKD N+ I + Q +LD IR + +L++
Sbjct: 1563 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1622
Query: 765 RMH------TLWQEHFKLVVLFSQMRLANFQ-------------TDSQESIQKILAVQEE 805
+M + H + + N Q SQE +++ LA+ E
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVER 1682
Query: 806 SSNLMQ 811
+NL+Q
Sbjct: 1683 RANLLQ 1688
Score = 62.8 bits (151), Expect = 1e-09
Identities = 126/622 (20%), Positives = 255/622 (40%), Gaps = 82/622 (13%)
Query: 83 RHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETSFEEWS--RTSSTKDLKEDWSVT 140
RH C ++ + + +Q SK + ++ T +E + RT ++ K+ +
Sbjct: 1343 RHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1402
Query: 141 TPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINM 200
E + E + KC L++ + L +E L+ +E A K+QR+ ++
Sbjct: 1403 LQAAE-EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL-- 1459
Query: 201 KIDSWSVWKLQ------ELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEE 254
+ WK + EL A QKE + +++ +++ E+ +QL+ +++ L++
Sbjct: 1460 -----AEWKQKCEETHAELE-ASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ 1513
Query: 255 ANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACEN 314
+ + I E G K+ EL+ +K ++ E +L + EE E +LE E
Sbjct: 1514 EISDLTEQIA---EGG-----KRIHELEKIKKQVEQ--EKCELQAAL-EEAEASLEHEEG 1562
Query: 315 ARLKAQ----QIKEEIDKDIYQDEKTIEAYKRE----IYQLNSLFD---HYSSSVINVNT 363
L+ Q Q+K E+D+ I + ++ I+ KR + + S D + I +
Sbjct: 1563 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1622
Query: 364 NIEEKEEEV-----------TEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHEN 412
+E E+ EA+R ++++ L L+D R + L + E
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVER 1682
Query: 413 Q--YLEA--------VNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINK 462
+ L+A + ++K + EL D ++ + T L KKLE DI++
Sbjct: 1683 RANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ 1742
Query: 463 ITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDK 522
+ + + +++ E + K + LK KE T HL + K + ME
Sbjct: 1743 MQGEMEDILQEARNAEEKAKKAITDAAMMAEELK---KEQ---DTSAHLERMKKN-MEQT 1795
Query: 523 IAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAE 582
+ +++ + E+ K + ++ ++L E + E +K + E
Sbjct: 1796 VKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE 1855
Query: 583 L-------QEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSKTMIFYAKINELNE 635
L ++ +L+L+D +++++ K + KR A E + ++ AK +L
Sbjct: 1856 LTYQTEEDRKNILRLQDLVDKLQAKVKSY---KRQA-----EEAEEQSNTNLAKFRKLQH 1907
Query: 636 ELKAKEEEKKSFDQTLEILKNK 657
EL+ EE + + L+ K
Sbjct: 1908 ELEEAEERADIAESQVNKLRVK 1929
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 80.1 bits (196), Expect = 8e-15
Identities = 167/846 (19%), Positives = 333/846 (39%), Gaps = 142/846 (16%)
Query: 98 KMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPG-EKRDEKC 156
K ++ +++ KI++ L + E +E T LKE + V+ G +E+C
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTL-LKEKNDLQLQVQAEAEGLADAEERC 911
Query: 157 PEL---KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQEL 213
+L K ++E + E ++ + + +AE K+++ +K D + EL
Sbjct: 912 DQLIKTKIQLEAKIKEVTE--RAEDEEEINAELTAKKRKLEDECSELKKDIDDL----EL 965
Query: 214 PLA-VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPL 272
LA V+KE A + V L + + K+K L+EA+ + D+ +
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 273 LDS---KQNQELQDLKNHYKKKMEV-MDLHRKVNEELEEALEACENARLKAQQIKEEIDK 328
L K Q++ DL+ +++ ++ MDL R +LE L+ + + + + K+++D+
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLER-AKRKLEGDLKLAQESIMDIENEKQQLDE 1084
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEV-------TEAIRETKS 381
+ + E I + +I +L + + IEE EEE+ +A ++
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1144
Query: 382 SKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAA-----------KKTWDI 430
EL +S+ LE+ K E ++ + D A +K
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Query: 431 ELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIK----YLTI 486
++++ + + KL ++ +++++I+ + + K E + L+
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSE 1264
Query: 487 MKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEF------LKKL 540
+K K ++ + I + G L + + ++++K A V + +G++ F LK+
Sbjct: 1265 LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ 1324
Query: 541 TQGEVAAGMVLQKKLYSI--------------------------------------YEVQ 562
+ E+ A L L S YE
Sbjct: 1325 LEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETD 1384
Query: 563 ALER-KELIKNRAICAMSL--------------AELQEPLLQLEDEAERIRSLDKEHSVS 607
A++R +EL + + A L A L++ +L++E E + LD E + +
Sbjct: 1385 AIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL-MLDVERTNA 1443
Query: 608 KRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREH 667
+A+ K + K E + EL+A ++E +S L +KN + + E
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLET 1503
Query: 668 AQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEEN--------- 718
+ + QE D E+I E +R L ++++ Q+ ++ A +LEE
Sbjct: 1504 LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA-ALEEAEASLEHEEG 1562
Query: 719 --LRLAQEYQQLQITF---LKEKD--------NYFNIYDK-QLSLDTSIRDKKQLCQLQR 764
LR+ E Q++ + EKD N+ I + Q +LD IR + +L++
Sbjct: 1563 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1622
Query: 765 RMH------TLWQEHFKLVVLFSQMRLANFQ-------------TDSQESIQKILAVQEE 805
+M + H + + N Q SQE +++ LA+ E
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVER 1682
Query: 806 SSNLMQ 811
+NL+Q
Sbjct: 1683 RANLLQ 1688
Score = 62.8 bits (151), Expect = 1e-09
Identities = 126/622 (20%), Positives = 255/622 (40%), Gaps = 82/622 (13%)
Query: 83 RHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETSFEEWS--RTSSTKDLKEDWSVT 140
RH C ++ + + +Q SK + ++ T +E + RT ++ K+ +
Sbjct: 1343 RHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1402
Query: 141 TPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINM 200
E + E + KC L++ + L +E L+ +E A K+QR+ ++
Sbjct: 1403 LQAAE-EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL-- 1459
Query: 201 KIDSWSVWKLQ------ELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEE 254
+ WK + EL A QKE + +++ +++ E+ +QL+ +++ L++
Sbjct: 1460 -----AEWKQKCEETHAELE-ASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ 1513
Query: 255 ANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACEN 314
+ + I E G K+ EL+ +K ++ E +L + EE E +LE E
Sbjct: 1514 EISDLTEQIA---EGG-----KRIHELEKIKKQVEQ--EKCELQAAL-EEAEASLEHEEG 1562
Query: 315 ARLKAQ----QIKEEIDKDIYQDEKTIEAYKRE----IYQLNSLFD---HYSSSVINVNT 363
L+ Q Q+K E+D+ I + ++ I+ KR + + S D + I +
Sbjct: 1563 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1622
Query: 364 NIEEKEEEV-----------TEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHEN 412
+E E+ EA+R ++++ L L+D R + L + E
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVER 1682
Query: 413 Q--YLEA--------VNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINK 462
+ L+A + ++K + EL D ++ + T L KKLE DI++
Sbjct: 1683 RANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ 1742
Query: 463 ITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDK 522
+ + + +++ E + K + LK KE T HL + K + ME
Sbjct: 1743 MQGEMEDILQEARNAEEKAKKAITDAAMMAEELK---KEQ---DTSAHLERMKKN-MEQT 1795
Query: 523 IAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAE 582
+ +++ + E+ K + ++ ++L E + E +K + E
Sbjct: 1796 VKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE 1855
Query: 583 L-------QEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSKTMIFYAKINELNE 635
L ++ +L+L+D +++++ K + KR A E + ++ AK +L
Sbjct: 1856 LTYQTEEDRKNILRLQDLVDKLQAKVKSY---KRQA-----EEAEEQSNTNLAKFRKLQH 1907
Query: 636 ELKAKEEEKKSFDQTLEILKNK 657
EL+ EE + + L+ K
Sbjct: 1908 ELEEAEERADIAESQVNKLRVK 1929
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 79.3 bits (194), Expect = 1e-14
Identities = 171/863 (19%), Positives = 356/863 (41%), Gaps = 121/863 (14%)
Query: 3 ENKTVSSSSTRDDQTNIGLTCQEVKALREKAWS----RTNEGNAMSQSLVLYGASKENSE 58
+ + V + T + + QE + E+ S RT E A Q L +KEN
Sbjct: 470 QQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEV 529
Query: 59 GFHESKMTNTEGVNKGIYFSYPCRRHSCAVVNIPAPCVNKMIS---HIQDVESKIQEHLK 115
SK+T+T + + ++ VNK S +QD+ + +
Sbjct: 530 QSLHSKLTDT------LVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKA 583
Query: 116 RFETSFEEWSRTSSTKDLKEDWS--VTTPVKEVKPGE-----KRD---EKCPELK--QEM 163
+ + + + +S L E+ + K++K E +RD K ELK Q M
Sbjct: 584 QIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNM 643
Query: 164 ETLLSEAIRLIKSLETDRADAEEAL-KQQRS------RKNMINMKIDSWSVWKLQELPLA 216
LL ++ +++L ++A A L K Q+S + ++ ++ K++E +
Sbjct: 644 NFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKI- 702
Query: 217 VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSK 276
+ +++A S+V +LQ + ++ N+ E+ + ++E + K++ ++ + E G + +
Sbjct: 703 LNDQNKALKSEVQKLQTLVSEQPNK-DVVEQMEKCIQEKDEKLKT-VEELLETGLIQVAT 760
Query: 277 QNQELQDLKNHYKK-KMEVMDLHRKVNEE------LEEALEACENARLKAQQIKEEIDKD 329
+ +EL ++ EV DL K N++ +EE + K + ++E ++ +
Sbjct: 761 KEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAE 820
Query: 330 IYQ---DEKTIEAYKREIYQLNSLFDH----------YSSSVINVNTNIEEKEEEVTEAI 376
+ + EKT++ K+EI L + +S V + ++ KEE++
Sbjct: 821 LLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMK 880
Query: 377 RETKSSKNELHSLSKMLEDLRRVYDQL----------TWKQKSHENQYLE---AVNDFYA 423
+ + +L + K L+DL+ + L K+ S +Q+ E + +
Sbjct: 881 AVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKEN 940
Query: 424 AKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKY 483
K + L + D S+ + + ++NK + I ++ + + +E +K
Sbjct: 941 ELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV 1000
Query: 484 LTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKK---- 539
++ + +K + ++ E + + K +E + ++ V + K E LKK
Sbjct: 1001 IS----EREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAK---EVLKKLFPK 1053
Query: 540 ------LTQGEVAAGMVLQKK-----LYSIYEVQALERKELIKNRAICAMSLAELQEPLL 588
L+ GE G + K EV+ LE K + A+ LL
Sbjct: 1054 VSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHK----------LKEADEMHTLL 1103
Query: 589 QLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFD 648
QLE E + + E + K + + +E ++K + K++E ++ +K + S +
Sbjct: 1104 QLECEKYKSVLAETEGILQK---LQRSVEQEENKWKV---KVDESHKTIKQMQSSFTSSE 1157
Query: 649 QTLEILK--NKFI-TMRFKREHAQTVFDH-------YMQEKKDCEERIFEEDQRFRVLLA 698
Q LE L+ NK I +R +REH + + Y+ E ++ + ++ E + R
Sbjct: 1158 QELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQN 1217
Query: 699 VRQKTLQDTQKIIADSLE----ENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIR 754
RQK D K SLE + ++ A + ++ + + + +SL+ ++
Sbjct: 1218 ERQKVAGDLHK-AQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVT 1276
Query: 755 DKKQLCQLQRRMHTLWQEHFKLV 777
+QL Q + T +EH++++
Sbjct: 1277 QLQQLLQAVNQQLTKEKEHYQVL 1299
Score = 75.9 bits (185), Expect = 1e-13
Identities = 149/765 (19%), Positives = 324/765 (42%), Gaps = 98/765 (12%)
Query: 109 KIQEHLKRFETSFEEWSRTSSTKDLKEDWSV-TTPVKEVKPGEKRDEKCPELKQEMETL- 166
K + + E F+++ + T ED ++ + + K G +D K E+ TL
Sbjct: 272 KTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLI 331
Query: 167 --LSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAY 224
L E +L+ +++ D A ++ KQ +++ M + + + ++++ ++KEH +
Sbjct: 332 HQLQEKDKLLAAVKEDAAATKDRCKQL-TQEMMTEKERSNVVITRMKDRIGTLEKEHNVF 390
Query: 225 LSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADI--DYMNEHGPLLDSKQNQELQ 282
+ + + + Q +Q E E A+ K + I D ++ L+SKQ+ EL
Sbjct: 391 QNKIHVSYQETQQMQMKFQQVREQM-EAEIAHLKQENGILRDAVSNTTNQLESKQSAELN 449
Query: 283 DLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKR 342
L+ Y + V +L K + +E ++ +NA A Q+K ++ + + E+ ++
Sbjct: 450 KLRQDYARL--VNELTEKTGKLQQEEVQK-KNAEQAATQLKVQLQEAERRWEEVQSYIRK 506
Query: 343 EIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQ 402
+ + S + ++ ++T+ + + + L L M + +RV
Sbjct: 507 RTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQL--MESEQKRVN-- 562
Query: 403 LTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINK 462
K++S + Q + + A K S +A SA LA E+ K+ + +K
Sbjct: 563 ---KEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLA-----EELHKVIAEKDK 614
Query: 463 ITVKTNESIRKK----SKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDE 518
+T +S+ + + E E+K + M LK ++ + H+ ++
Sbjct: 615 QIKQTEDSLASERDRLTSKEEELKDIQNMNFL----LKAEVQKLQALANEQAAAAHELEK 670
Query: 519 MEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIY-EVQALE-------RKELI 570
M+ + K + EE L+ ++ +L + ++ EVQ L+ K+++
Sbjct: 671 MQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVV 730
Query: 571 KNRAICAMSLAE--------LQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSK 622
+ C E L+ L+Q+ + E + ++ E+S + +DL+A ++
Sbjct: 731 EQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV--QDLKAKQND 788
Query: 623 TMIFYAKINELNEELKAKEEEKKSFDQTLE--ILK--NKFITMRFKREHAQTVFDHY--- 675
+ F + + EL + + K+ + KS ++ LE +LK NK T++ ++ + + +
Sbjct: 789 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNV 848
Query: 676 -------------MQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRL- 721
+QE ++ + E+ + +L ++K L +T K + D EEN L
Sbjct: 849 QLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLK 908
Query: 722 ----------------AQEYQQLQITFLKEKDNYFNIYDKQL-SLDTSIRDKKQLCQLQR 764
A ++++L+I LKEK+N + L ++ + K QL Q +
Sbjct: 909 AHVQEVAQHNLKEASSASQFEELEIV-LKEKENELKRLEAMLKERESDLSSKTQLLQDVQ 967
Query: 765 RMHTLWQEHFKLVVLFSQMRLANFQTDS----QESIQKILAVQEE 805
+ L++ + Q++ N+Q S E + K+++ +E+
Sbjct: 968 DENKLFKSQIE------QLKQQNYQQASSFPPHEELLKVISEREK 1006
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 79.3 bits (194), Expect = 1e-14
Identities = 137/724 (18%), Positives = 293/724 (40%), Gaps = 75/724 (10%)
Query: 150 EKRDEKCPELKQEMETLLSEAIRL---IKSLETDRADAEEALKQQRSRKNMINMKIDSWS 206
EK + + EL+++M +LL E L +++ + + DAEE Q K + K+ +
Sbjct: 866 EKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMN 925
Query: 207 --VWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQK-------TELEEANA 257
+ +E+ + + + EL+ ++D L EK+K L E A
Sbjct: 926 ERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 985
Query: 258 KIQADIDYMNEHGPLLDSKQNQELQDL-----------KNHYKKKMEVMDLH------RK 300
+ I + + L Q L DL K+ K + +V DL +K
Sbjct: 986 GLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKK 1045
Query: 301 VNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVIN 360
V +LE A E Q+ +++ D Q E+ ++ + +I Q NS + +
Sbjct: 1046 VRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQ 1105
Query: 361 VNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWK-------------- 406
+ ++E + + E E ++ + + K+ DL R ++++ +
Sbjct: 1106 LQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEM 1165
Query: 407 QKSHENQYLEAVNDF-----------YAAKKTWDIELSDVAKDFSAISLACTKLTEDNKK 455
K E ++ + D A +K ++++ + + KL ++ +
Sbjct: 1166 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1225
Query: 456 LEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHK 515
+++++ +T + I+ K+ E + T+ N+ +K +EA R +L T +
Sbjct: 1226 FKLELDDVTSNMEQIIKAKANLEKVSR--TLEDQANEYRVK--LEEAQR--SLNDFTTQR 1279
Query: 516 TDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAI 575
+++ + E+ R+ + +E + +LT+G+++ ++ + LE + KN
Sbjct: 1280 A-KLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDL------KRQLEEEGKAKNALA 1332
Query: 576 CAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSKTMIFYAKINELNE 635
A+ A LL+ + E E + + +SK ++ TK +T + EL E
Sbjct: 1333 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWR-TKYETDAI-QRTEELEE 1390
Query: 636 ELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYM--QEKKDCEERIFEEDQR- 692
K + + ++ +E + K ++ + Q + M E+ + ++ QR
Sbjct: 1391 AKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRN 1450
Query: 693 FRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTS 752
F +LA ++ +++Q + S +E L+ E +L+ + + ++ + +L
Sbjct: 1451 FDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEE 1510
Query: 753 IRD-KKQLCQLQRRMHTLWQEHFKLVV--LFSQMRLANFQTDSQESIQKILAVQEESSNL 809
I D +QL + + +H L + +L V L Q L + + KIL Q E + +
Sbjct: 1511 ISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQI 1570
Query: 810 MQHI 813
I
Sbjct: 1571 KAEI 1574
Score = 74.7 bits (182), Expect = 3e-13
Identities = 135/626 (21%), Positives = 272/626 (43%), Gaps = 85/626 (13%)
Query: 83 RHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETSFEEWS--RTSSTKDLKEDWSVT 140
RH C ++ + + +Q V SK + ++ T +E + RT ++ K+ +
Sbjct: 1339 RHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1398
Query: 141 TPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINM 200
E + E + KC L++ L +E L+ +E A A K+QR+ ++
Sbjct: 1399 LQDAE-EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKIL-- 1455
Query: 201 KIDSWSVWKLQ------ELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEE 254
+ WK + EL + QKE + +++ +L+ E+ L+ F+++ L+E
Sbjct: 1456 -----AEWKQKYEESQSELESS-QKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQE 1509
Query: 255 ANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLH-RKVNEELEEALEACE 313
+I + + E G K EL+ ++ K++EV L + EE E +LE E
Sbjct: 1510 ---EISDLTEQLGEGG-----KNVHELEKVR----KQLEVEKLELQSALEEAEASLEHEE 1557
Query: 314 NARLKAQ----QIKEEIDKDIYQDEKTIEAYKRE----IYQLNSLFDHYSSS---VINVN 362
L+AQ QIK EI++ + + ++ +E KR + L + D + S V+ V
Sbjct: 1558 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVK 1617
Query: 363 TNIE----EKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQK---------S 409
+E E E +++ A R ++ ++ SL +L+D + D
Sbjct: 1618 KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVE 1677
Query: 410 HENQYLEA--------VNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDIN 461
N L+A V ++K + EL + ++ + T L KK+E D+
Sbjct: 1678 RRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLT 1737
Query: 462 KITVKTNESIRKKSKYESEIK------YLTIMKLKNDK----HLKNIYKEAYRIGTLFHL 511
++ + E++++ E + K + +LK ++ HL+ + K + T+ L
Sbjct: 1738 QLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ--TIKDL 1795
Query: 512 TKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALER--KEL 569
+H+ DE E + +K + E + +GE+ A ++ S+ ++ ER KEL
Sbjct: 1796 -QHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQ--KRNAESVKGMRKSERRIKEL 1852
Query: 570 IKNRAICAMSLAELQEPL--LQLEDEAERIRSLDKEH----SVSKRSAIFKDLEATKSKT 623
+L LQ+ + LQL+ +A + ++ + E ++SK + +L+ + +
Sbjct: 1853 TYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1912
Query: 624 MIFYAKINELNEELKAKEEEKKSFDQ 649
I +++N+L + + ++K D+
Sbjct: 1913 DIAESQVNKLRAKSRDIGAKQKMHDE 1938
Score = 71.2 bits (173), Expect = 4e-12
Identities = 143/746 (19%), Positives = 295/746 (39%), Gaps = 112/746 (15%)
Query: 96 VNKMISHIQD-------VESKIQEHLKRFETSFEEWS--RTSSTK--DLKEDWS-----V 139
+N+ S I+D ++ K++E+ R E EE RT+ K L+ D S +
Sbjct: 1089 INQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEI 1148
Query: 140 TTPVKE--------VKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQ 191
+ ++E ++ +KR+ + ++++++E + +L AD+ L +Q
Sbjct: 1149 SERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQ 1208
Query: 192 RSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTE 251
ID+ LQ + ++KE E + L+D + ++ K K
Sbjct: 1209 ----------IDN-----LQRVKQKLEKEKS-------EFKLELDDVTSNMEQIIKAKAN 1246
Query: 252 LEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEA 311
LE+ + ++ D NE+ L+ Q K + E +L R++ EE E +
Sbjct: 1247 LEKVSRTLE---DQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQL-EEKEALISQ 1302
Query: 312 CENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEE 371
+L Q E++ + + ++ K A H S + + E+ EE
Sbjct: 1303 LTRGKLSYTQQMEDLKRQLEEEGKAKNA-----------LAHALQSARHDCDLLREQYEE 1351
Query: 372 VTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIE 431
TEA E + ++ +S + W+ K +E ++ + AKK
Sbjct: 1352 ETEAKAELQRVLSKANS------------EVAQWRTK-YETDAIQRTEELEEAKKKLAQR 1398
Query: 432 LSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNES----IRKKSKYESEIKYLTIM 487
L D + A++ C+ L + +L+ +I + V S K + K L
Sbjct: 1399 LQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEW 1458
Query: 488 KLK---NDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQ-- 542
K K + L++ KEA + T K+ +E + + +R+ K +E + LT+
Sbjct: 1459 KQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL 1518
Query: 543 GEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDK 602
GE + +K+ EV+ LE + ++ SL + +L+ + E +I+
Sbjct: 1519 GEGGKNVHELEKVRKQLEVEKLELQSALEE---AEASLEHEEGKILRAQLEFNQIK---- 1571
Query: 603 EHSVSKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMR 662
+ +R KD E ++K ++ L L A+ + + + ++ M
Sbjct: 1572 --AEIERKLAEKDEEMEQAKRN-HQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEME 1628
Query: 663 FKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLA 722
+ HA + ++ K + + +D + ++ AVR D L+EN+ +
Sbjct: 1629 IQLSHANRMAAEAQKQVKSLQSLL--KDTQIQLDDAVRAN----------DDLKENIAIV 1676
Query: 723 QEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQ 782
+ L L+E ++ L +++L + R+ L ++ L+ +
Sbjct: 1677 ERRNNLLQAELEELRAVVEQTERSRKL-----AEQELIETSERVQLLHSQNTSLINQKKK 1731
Query: 783 MR--LANFQTDSQESIQKILAVQEES 806
M L Q++ +E++Q+ +E++
Sbjct: 1732 MESDLTQLQSEVEEAVQECRNAEEKA 1757
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 79.0 bits (193), Expect = 2e-14
Identities = 133/677 (19%), Positives = 277/677 (40%), Gaps = 88/677 (12%)
Query: 102 HIQDVESKIQEHLKRFETSFEEWSRT-SSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELK 160
H+ +ES +++ K EE R + D + ++ T + E +D K ++
Sbjct: 342 HVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVI------EMKDSKISSME 395
Query: 161 QEMETLLSEAIRLIKS---LETDRADAEEALKQQ---RSRKNMINMKIDS---------- 204
+ + L E I+++KS L T+ + EE +KQ RS + K++
Sbjct: 396 RGLRDL-EEEIQMLKSNGALSTE--EREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEA 452
Query: 205 -WSVWKLQELPLA-----VQKEHEAYLSDVIELQWHLEDKANQL----QHFEKQKTEL-- 252
W K + L V++E ++++ LQ LE NQ QH E K L
Sbjct: 453 QWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTA 512
Query: 253 -EEANAKIQADIDYMN---EHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEA 308
E+ A +Q ++D + E + +K+ +++QD+ +K + ++H +L++
Sbjct: 513 KEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAE--EKGTQAGEIH-----DLKDM 565
Query: 309 LEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEK 368
L+ E Q+ E + + + EK + + K + L + + +++ + + EK
Sbjct: 566 LDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEK 625
Query: 369 EEEVT----EAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAA 424
E + + R+ + + E+ + K L+DL+ L E L+
Sbjct: 626 ERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDL------K 679
Query: 425 KKTWDIELSDVAKD--FSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIK 482
+ + S + KD + +A + E+ K+E + K E+ R + I+
Sbjct: 680 EHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEA-RASPEMSDRIQ 738
Query: 483 YLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQ 542
+L + E R+ + +++ ++ + KIAE+ R+ K + + + L
Sbjct: 739 HLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKH 798
Query: 543 GEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDE--------A 594
E V +KK + E L + SL + + + +LE+ A
Sbjct: 799 KE----QVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITA 854
Query: 595 ERIRSLDKEHSVSKRSA-----IFKDLEATKSKTMIFYAKINELNEELKAKE-------- 641
ER L +E S + + +E K + AK++ + L KE
Sbjct: 855 EREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRA 914
Query: 642 EEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQ 701
E +K ++ LE+ + + +++ + + +KK EE + ++ R++ ++Q
Sbjct: 915 ERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ 974
Query: 702 KTLQDTQKIIADSLEEN 718
+T Q+ K++AD+ E++
Sbjct: 975 QT-QNRMKLMADNYEDD 990
Score = 64.3 bits (155), Expect = 4e-10
Identities = 93/451 (20%), Positives = 203/451 (45%), Gaps = 63/451 (13%)
Query: 89 VNIPAPCVNKMISHIQDVE---SKIQEHLKRFE--TSFEEWSRTSSTKDLKEDWSVTTPV 143
VN+ + + ++D E S ++E +K + T+ + + T+ + L E +
Sbjct: 573 VNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERL 632
Query: 144 KEVKPGEKRD--EKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMK 201
KE + ++R+ E+ K++++ L E + L++ +++ + LK+ S +K
Sbjct: 633 KEQRDRDEREKQEEIDNYKKDLKDL-KEKVSLLQGDLSEKEASLLDLKEHASSLASSGLK 691
Query: 202 IDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLE---------DKANQLQHFEKQKTEL 252
DS +L+ L +A++++ E L +L+ E + ++++QH E++ T
Sbjct: 692 KDS----RLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRY 747
Query: 253 EEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKV----------- 301
++ ++K QA++D + E +L +N++ K + + +V D ++KV
Sbjct: 748 KDESSKAQAEVDRLLE---ILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEK 804
Query: 302 ---NEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSV 358
+ LEEA +N +QQ+++ + K + E+ EA RE Q+ + + +
Sbjct: 805 KKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEAL-RESVQITAEREMVLAQE 863
Query: 359 INVNTNIEEKEEEVTEAI----RETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQY 414
+ TN E++ EE+ A+ +E +S K +L S + L + L +++ H +
Sbjct: 864 ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEV 923
Query: 415 LEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKK 474
LE + A A ++A +L+ KK + ++ + R+K
Sbjct: 924 LEMKQEALLA-----------AISEKDANIALLELSSSKKKTQEEVAALK-------REK 965
Query: 475 SKYESEIKYLT--IMKLKNDKHLKNIYKEAY 503
+ ++K T MKL D + + +K ++
Sbjct: 966 DRLVQQLKQQTQNRMKLMADNYEDDHFKSSH 996
Score = 54.3 bits (129), Expect = 5e-07
Identities = 117/586 (19%), Positives = 234/586 (39%), Gaps = 116/586 (19%)
Query: 273 LDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENA-------RLKAQQI--K 323
L ++ + DL+ K+ + DL RK E E L + N+ LK ++ K
Sbjct: 143 LRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRK 202
Query: 324 EEIDK--------DIYQDEK-----TIEAYKREIY---QLNSLFDHYSSSVINVNTNIEE 367
+E K + Q+E TI+A + E+ LN LF SSS E
Sbjct: 203 DEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAEL 262
Query: 368 KEEEVTEAIRETKSSKNELHSLSKMLEDLR-RVYDQLTWKQKSHEN--QYLEAVNDFYAA 424
EE E + EL L K LE++ R+ Q E+ + LE + +
Sbjct: 263 TEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLS 322
Query: 425 KKTWDIE------LSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYE 478
K + + L++ + + ++N L ++++ +S + K+
Sbjct: 323 AKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKA--- 379
Query: 479 SEIKYLTIMKLKNDK------HLKNIYKEAYRIGTLFHLTKHKTDE-------------- 518
T++++K+ K L+++ +E + + L+ + +E
Sbjct: 380 ----LQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKF 435
Query: 519 MEDKIAEVRRKFKGRE---EFLKKLTQG-EVAAGMVLQKKLYSIYEVQALERK------- 567
M++K+ +++ + +E E LKK G + G V Q+ E+ AL+ K
Sbjct: 436 MKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQ 495
Query: 568 --------ELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKD---- 615
E++K +++ E + +LQ E +A R+R +KE ++K++ +D
Sbjct: 496 FSDSKQHIEVLKE----SLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEE 551
Query: 616 --------------LEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITM 661
L+ + K + KI L E+L+ KE++ S + ++ L+
Sbjct: 552 KGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQ----AD 607
Query: 662 RFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRL 721
+ A T + + EK+ ER+ E+ R +Q+ + + +K + D E+ L
Sbjct: 608 TTNTDTALTTLEEALAEKERTIERLKEQRDRDE---REKQEEIDNYKKDLKDLKEKVSLL 664
Query: 722 AQEYQQLQITFLKEKDNYFNIYDKQL-------SLDTSIRDKKQLC 760
+ + + + L K++ ++ L +L+ ++ KK+ C
Sbjct: 665 QGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEEC 710
Score = 52.8 bits (125), Expect = 1e-06
Identities = 97/490 (19%), Positives = 198/490 (40%), Gaps = 94/490 (19%)
Query: 348 NSLFDHYSSSVINVNTNIEE--KEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTW 405
+SL ++++++ T ++E +E ++ E K SK LS + ++ +
Sbjct: 141 HSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESK-----LSSSMNSIKTFWSPELK 195
Query: 406 KQKSHENQYLEAVNDFYAAKKT-WDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKIT 464
K++ A+ A+K T W + V ++ + + L +D +++ D+N++
Sbjct: 196 KER--------ALRKDEASKITIWKEQYRVVQEENQHMQMTIQAL-QDELRIQRDLNQL- 245
Query: 465 VKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIA 524
+ + S R +E+ +++ + ++ E R L + +EME +I
Sbjct: 246 FQQDSSSRTGEPCVAEL---------TEENFQRLHAEHERQAKELFLLRKTLEEMELRIE 296
Query: 525 EVRRKFKGREEFLKKLTQGEVAAGM--------------VLQKKLYSIYEVQALERKE-- 568
++ R+E +KKL + + G+ + + +++ + LE+KE
Sbjct: 297 TQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKE 356
Query: 569 -----------------LIKNRAICAM------SLAELQEPLLQLEDEAERIRSLDKEHS 605
K +A+ + ++ ++ L LE+E + ++S + S
Sbjct: 357 NSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKS-NGALS 415
Query: 606 VSKRSAIFKDLEATKSKTMIFYAKINELNEELKAKE---EEKK-----------SFDQTL 651
+R K +E +S + K+ +L EEL +KE EE K Q L
Sbjct: 416 TEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQEL 475
Query: 652 EILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQR----------FRVLLAVRQ 701
+ + ++ K E F Q + +E + ++QR R+ L ++
Sbjct: 476 SRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE 535
Query: 702 KTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQL-SLDTSIRDK-KQL 759
L K I D EE A E L+ L K+ N+ K++ +L +RDK KQ+
Sbjct: 536 TMLNKKTKQIQDMAEEKGTQAGEIHDLK-DMLDVKERKVNVLQKKIENLQEQLRDKEKQM 594
Query: 760 CQLQRRMHTL 769
L+ R+ +L
Sbjct: 595 SSLKERVKSL 604
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 79.0 bits (193), Expect = 2e-14
Identities = 142/748 (18%), Positives = 303/748 (40%), Gaps = 86/748 (11%)
Query: 102 HIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPG-EKRDEKCPELK 160
H D+E ++ + K ++ E + L++ V + +K EK EL+
Sbjct: 1887 HKADIEERLAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1945
Query: 161 QEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKE 220
E+ + S A ++S E +A+ E A ++Q + + + V K ++
Sbjct: 1946 LELGRIRSNAEDTLRSKE--QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2003
Query: 221 HEAYLSDVIELQWHLEDKANQLQHFEKQKTEL-----EEANAKIQADIDYMNEHGPLLDS 275
+A L +V L+ +E+ + E++ E A ++QA+ H +
Sbjct: 2004 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQ 2060
Query: 276 KQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEK 335
K+ Q+L+ +++ V+D R E A E E AR++A +++ Q +
Sbjct: 2061 KE----QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA-------EREAAQSRR 2109
Query: 336 TIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLED 395
+E +R + + +E E+E + +++ + + +E
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2169
Query: 396 LRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKK 455
++ +Q T +QK+ Q L + + D + + + ++ + T+ +
Sbjct: 2170 HKKFAEQ-TLRQKAQVEQELTTLR---LQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2225
Query: 456 LEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKH--------LKNIYKEAYRIGT 507
+E ++ + V+ E + K++ E+E + L + N + +K + +EA R+
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285
Query: 508 LFHLTKHKTDEMEDKIAEVR----RKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQA 563
E+ +A+ R + K + + +++ T+ + A ++ Q+K E+
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK-----ELAQ 2340
Query: 564 LERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSK- 622
+ + L +++ A LAE + Q EAER R L+ + ++ +++
Sbjct: 2341 EQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2399
Query: 623 ---TMIFYAKINELNEELKAKE---EEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYM 676
F + E+ E+L E +EK + QTLEI R + +H +
Sbjct: 2400 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-------QRQQSDHDAERLREAI 2452
Query: 677 QEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEK 736
E + +E++ +E + LL ++ + +Q Q+ +L QE Q LQ +FL EK
Sbjct: 2453 AELEREKEKLQQEAK----LLQLKSEEMQTVQQ---------EQLLQETQALQQSFLSEK 2499
Query: 737 DNYFN----IYDKQLSLDTSIRDKKQLCQ-----LQRRMHTLWQEHFKLVVLFSQMRLAN 787
D+ I ++ L+ +D+ Q QR+ + QE +LV + R
Sbjct: 2500 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2559
Query: 788 FQTD-----SQESIQKILAVQEESSNLM 810
+ + QE +Q++ + + L+
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQRRQQEELL 2587
Score = 60.5 bits (145), Expect = 6e-09
Identities = 116/673 (17%), Positives = 270/673 (40%), Gaps = 90/673 (13%)
Query: 151 KRDEKCPELKQEMETLLSEAIRLIKSLETD-RADAEEALKQQRSRKNMINMKIDSWSVWK 209
+R+E + +Q+ ++ E +L +S E + +A A +A +RSR +
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL-------------R 1449
Query: 210 LQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEH 269
++E V+ + EA + L+ + + E QK + +E +++ +
Sbjct: 1450 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ----- 1504
Query: 270 GPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKD 329
D Q + +++ + K E + E + AL+A E RL+A++ + + +
Sbjct: 1505 ----DESQRKRQAEVELASRVKAEA-----EAAREKQRALQALEELRLQAEEAERRLRQA 1555
Query: 330 IYQDEKTIE-----AYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKN 384
+ + ++ A + +L S ++ + +++E+ V + E +
Sbjct: 1556 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 385 ELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISL 444
+ + E+ R ++ W+ K++E L + A +K SL
Sbjct: 1616 QQAEAERAREEAERELER--WQLKANEALRLRLQAEEVAQQK----------------SL 1657
Query: 445 ACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYR 504
A + + ++ E + + +++R++ E E++ + + +E R
Sbjct: 1658 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1717
Query: 505 IGTLFHLTKHKTDEMEDKIAEVRRKFKG----REEFLKKLTQGEVAAGMVLQKKLYSIYE 560
+ + + +E+++A ++R+ R+E +L + ++L K + E
Sbjct: 1718 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1777
Query: 561 VQALERK--ELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEA 618
++ K + ++ A LAE L L +EA+R R L +E + +R+ + E
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA----EAER 1833
Query: 619 TKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQE 678
++ + + L E + +EK++ ++ L L R + E + Q
Sbjct: 1834 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE------EQAAQH 1887
Query: 679 KKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLK---- 734
K D EER+ + L L+ + ++ D+L + ++ +E L+ +F K
Sbjct: 1888 KADIEERLAQ-------LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1940
Query: 735 EKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQE 794
+ + + + + + ++R K+Q R L E + + +++E
Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR------------RREAEE 1988
Query: 795 SIQKILAVQEESS 807
+QK LA +EE++
Sbjct: 1989 RVQKSLAAEEEAA 2001
Score = 44.7 bits (104), Expect = 4e-04
Identities = 108/596 (18%), Positives = 243/596 (40%), Gaps = 66/596 (11%)
Query: 161 QEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKID---SWSVWKLQELPLA- 216
Q + L + L++ +E EE QR K IN D +K Q P+A
Sbjct: 1242 QAVREQLRQEQALLEEIERHGEKVEEC---QRFAKQYINAIKDYELQLVTYKAQLEPVAS 1298
Query: 217 ------VQKEHEAYLSDVIELQWHLEDKANQLQHFEK------QKTELEEANAKIQA--D 262
VQ E+ + + ++L+ H + + K ++ E EE A+ Q +
Sbjct: 1299 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1358
Query: 263 IDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQI 322
+ + E L+ ++ + + + E +L +++ EE+ EA +A+ + + I
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 323 KEEIDKDIYQDEKTIEAYKR--EIYQLNSLFDHYSSSVINVNTNIEEKE----EEVTEAI 376
+EE+ + E I+A R E + + L V+ + E++ E +A+
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478
Query: 377 R----ETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIEL 432
R E ++ K + ++ L R+V D+ K+++ + AA+ E
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLR--RQVQDESQRKRQAEVELASRVKAEAEAAR-----EK 1531
Query: 433 SDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKND 492
+ + L + ++ E++ + E+ ++ ++ E + K + + K
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTA 1590
Query: 493 KHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQ 552
+ +++ +E + L +E E + + + REE ++L + ++ A L+
Sbjct: 1591 QLERSLQEEHVAVAQL-------REEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643
Query: 553 KKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAI 612
+ L+ +E+ + + +++ AE ++ + E EA R R +E +V +R
Sbjct: 1644 LR---------LQAEEVAQQK---SLAQAEAEKQKEEAEREARR-RGKAEEQAVRQRELA 1690
Query: 613 FKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVF 672
++LE + + +EL E + +Q ++L+ + R +RE A
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL--ARLQREAAAAT- 1747
Query: 673 DHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQL 728
Q++++ E + + VLLA + + ++++ S + A +++L
Sbjct: 1748 ----QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799
Score = 40.8 bits (94), Expect = 0.005
Identities = 54/250 (21%), Positives = 105/250 (42%), Gaps = 24/250 (9%)
Query: 100 ISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVT-TPVKEVK------PGEKR 152
++ + +++ +E +RF EE +L VT E++ E+
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2448
Query: 153 DEKCPELKQEMETLLSEAIRL-IKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQ 211
E EL++E E L EA L +KS E E+ L++ ++ + + DS + + +
Sbjct: 2449 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRER 2507
Query: 212 ELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTEL----EEANAKIQADIDYMN 267
+ K + + +V + Q E++ Q Q E+++ L EEA + +
Sbjct: 2508 FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR-----QHEA 2562
Query: 268 EHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEID 327
E G ++ +ELQ L+ +++ E++ + N+ L E L+ E A EE+
Sbjct: 2563 EEGV---RRKQEELQQLEQQRRQQEELL---AEENQRLREQLQLLEEQHRAALAHSEEVT 2616
Query: 328 KDIYQDEKTI 337
KT+
Sbjct: 2617 ASQVAATKTL 2626
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 79.0 bits (193), Expect = 2e-14
Identities = 142/748 (18%), Positives = 303/748 (40%), Gaps = 86/748 (11%)
Query: 102 HIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPG-EKRDEKCPELK 160
H D+E ++ + K ++ E + L++ V + +K EK EL+
Sbjct: 1891 HKADIEERLAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1949
Query: 161 QEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKE 220
E+ + S A ++S E +A+ E A ++Q + + + V K ++
Sbjct: 1950 LELGRIRSNAEDTLRSKE--QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2007
Query: 221 HEAYLSDVIELQWHLEDKANQLQHFEKQKTEL-----EEANAKIQADIDYMNEHGPLLDS 275
+A L +V L+ +E+ + E++ E A ++QA+ H +
Sbjct: 2008 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQ 2064
Query: 276 KQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEK 335
K+ Q+L+ +++ V+D R E A E E AR++A +++ Q +
Sbjct: 2065 KE----QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA-------EREAAQSRR 2113
Query: 336 TIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLED 395
+E +R + + +E E+E + +++ + + +E
Sbjct: 2114 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2173
Query: 396 LRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKK 455
++ +Q T +QK+ Q L + + D + + + ++ + T+ +
Sbjct: 2174 HKKFAEQ-TLRQKAQVEQELTTLR---LQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2229
Query: 456 LEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKH--------LKNIYKEAYRIGT 507
+E ++ + V+ E + K++ E+E + L + N + +K + +EA R+
Sbjct: 2230 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2289
Query: 508 LFHLTKHKTDEMEDKIAEVR----RKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQA 563
E+ +A+ R + K + + +++ T+ + A ++ Q+K E+
Sbjct: 2290 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK-----ELAQ 2344
Query: 564 LERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEATKSK- 622
+ + L +++ A LAE + Q EAER R L+ + ++ +++
Sbjct: 2345 EQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2403
Query: 623 ---TMIFYAKINELNEELKAKE---EEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYM 676
F + E+ E+L E +EK + QTLEI R + +H +
Sbjct: 2404 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-------QRQQSDHDAERLREAI 2456
Query: 677 QEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEK 736
E + +E++ +E + LL ++ + +Q Q+ +L QE Q LQ +FL EK
Sbjct: 2457 AELEREKEKLQQEAK----LLQLKSEEMQTVQQ---------EQLLQETQALQQSFLSEK 2503
Query: 737 DNYFN----IYDKQLSLDTSIRDKKQLCQ-----LQRRMHTLWQEHFKLVVLFSQMRLAN 787
D+ I ++ L+ +D+ Q QR+ + QE +LV + R
Sbjct: 2504 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2563
Query: 788 FQTD-----SQESIQKILAVQEESSNLM 810
+ + QE +Q++ + + L+
Sbjct: 2564 HEAEEGVRRKQEELQQLEQQRRQQEELL 2591
Score = 60.5 bits (145), Expect = 6e-09
Identities = 116/673 (17%), Positives = 270/673 (40%), Gaps = 90/673 (13%)
Query: 151 KRDEKCPELKQEMETLLSEAIRLIKSLETD-RADAEEALKQQRSRKNMINMKIDSWSVWK 209
+R+E + +Q+ ++ E +L +S E + +A A +A +RSR +
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL-------------R 1453
Query: 210 LQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEH 269
++E V+ + EA + L+ + + E QK + +E +++ +
Sbjct: 1454 IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ----- 1508
Query: 270 GPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKD 329
D Q + +++ + K E + E + AL+A E RL+A++ + + +
Sbjct: 1509 ----DESQRKRQAEVELASRVKAEA-----EAAREKQRALQALEELRLQAEEAERRLRQA 1559
Query: 330 IYQDEKTIE-----AYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKN 384
+ + ++ A + +L S ++ + +++E+ V + E +
Sbjct: 1560 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1619
Query: 385 ELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISL 444
+ + E+ R ++ W+ K++E L + A +K SL
Sbjct: 1620 QQAEAERAREEAERELER--WQLKANEALRLRLQAEEVAQQK----------------SL 1661
Query: 445 ACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYR 504
A + + ++ E + + +++R++ E E++ + + +E R
Sbjct: 1662 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1721
Query: 505 IGTLFHLTKHKTDEMEDKIAEVRRKFKG----REEFLKKLTQGEVAAGMVLQKKLYSIYE 560
+ + + +E+++A ++R+ R+E +L + ++L K + E
Sbjct: 1722 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1781
Query: 561 VQALERK--ELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAIFKDLEA 618
++ K + ++ A LAE L L +EA+R R L +E + +R+ + E
Sbjct: 1782 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA----EAER 1837
Query: 619 TKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQE 678
++ + + L E + +EK++ ++ L L R + E + Q
Sbjct: 1838 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE------EQAAQH 1891
Query: 679 KKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLK---- 734
K D EER+ + L L+ + ++ D+L + ++ +E L+ +F K
Sbjct: 1892 KADIEERLAQ-------LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1944
Query: 735 EKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQE 794
+ + + + + + ++R K+Q R L E + + +++E
Sbjct: 1945 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR------------RREAEE 1992
Query: 795 SIQKILAVQEESS 807
+QK LA +EE++
Sbjct: 1993 RVQKSLAAEEEAA 2005
Score = 44.7 bits (104), Expect = 4e-04
Identities = 108/596 (18%), Positives = 243/596 (40%), Gaps = 66/596 (11%)
Query: 161 QEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKID---SWSVWKLQELPLA- 216
Q + L + L++ +E EE QR K IN D +K Q P+A
Sbjct: 1246 QAVREQLRQEQALLEEIERHGEKVEEC---QRFAKQYINAIKDYELQLVTYKAQLEPVAS 1302
Query: 217 ------VQKEHEAYLSDVIELQWHLEDKANQLQHFEK------QKTELEEANAKIQA--D 262
VQ E+ + + ++L+ H + + K ++ E EE A+ Q +
Sbjct: 1303 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1362
Query: 263 IDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQI 322
+ + E L+ ++ + + + E +L +++ EE+ EA +A+ + + I
Sbjct: 1363 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1422
Query: 323 KEEIDKDIYQDEKTIEAYKR--EIYQLNSLFDHYSSSVINVNTNIEEKE----EEVTEAI 376
+EE+ + E I+A R E + + L V+ + E++ E +A+
Sbjct: 1423 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1482
Query: 377 R----ETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIEL 432
R E ++ K + ++ L R+V D+ K+++ + AA+ E
Sbjct: 1483 RARAEEAEAQKRQAQEEAERLR--RQVQDESQRKRQAEVELASRVKAEAEAAR-----EK 1535
Query: 433 SDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKND 492
+ + L + ++ E++ + E+ ++ ++ E + K + + K
Sbjct: 1536 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE-KTA 1594
Query: 493 KHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQ 552
+ +++ +E + L +E E + + + REE ++L + ++ A L+
Sbjct: 1595 QLERSLQEEHVAVAQL-------REEAERRAQQQAEAERAREEAERELERWQLKANEALR 1647
Query: 553 KKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVSKRSAI 612
+ L+ +E+ + + +++ AE ++ + E EA R R +E +V +R
Sbjct: 1648 LR---------LQAEEVAQQK---SLAQAEAEKQKEEAEREARR-RGKAEEQAVRQRELA 1694
Query: 613 FKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVF 672
++LE + + +EL E + +Q ++L+ + R +RE A
Sbjct: 1695 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL--ARLQREAAAAT- 1751
Query: 673 DHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQL 728
Q++++ E + + VLLA + + ++++ S + A +++L
Sbjct: 1752 ----QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1803
Score = 40.8 bits (94), Expect = 0.005
Identities = 54/250 (21%), Positives = 105/250 (42%), Gaps = 24/250 (9%)
Query: 100 ISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVT-TPVKEVK------PGEKR 152
++ + +++ +E +RF EE +L VT E++ E+
Sbjct: 2393 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2452
Query: 153 DEKCPELKQEMETLLSEAIRL-IKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQ 211
E EL++E E L EA L +KS E E+ L++ ++ + + DS + + +
Sbjct: 2453 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRER 2511
Query: 212 ELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTEL----EEANAKIQADIDYMN 267
+ K + + +V + Q E++ Q Q E+++ L EEA + +
Sbjct: 2512 FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR-----QHEA 2566
Query: 268 EHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEID 327
E G ++ +ELQ L+ +++ E++ + N+ L E L+ E A EE+
Sbjct: 2567 EEGV---RRKQEELQQLEQQRRQQEELL---AEENQRLREQLQLLEEQHRAALAHSEEVT 2620
Query: 328 KDIYQDEKTI 337
KT+
Sbjct: 2621 ASQVAATKTL 2630
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.127 0.348
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,880,117
Number of Sequences: 37866
Number of extensions: 1220577
Number of successful extensions: 9711
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 174
Number of HSP's successfully gapped in prelim test: 762
Number of HSP's that attempted gapping in prelim test: 5470
Number of HSP's gapped (non-prelim): 2792
length of query: 829
length of database: 18,247,518
effective HSP length: 111
effective length of query: 718
effective length of database: 14,044,392
effective search space: 10083873456
effective search space used: 10083873456
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.