Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 157419152
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157419152 protein tyrosine phosphatase, receptor type, M
isoform 1 precursor [Homo sapiens]
(1465 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 3015 0.0
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 2979 0.0
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 1963 0.0
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 1951 0.0
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 1848 0.0
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 1841 0.0
gi|110735404 protein tyrosine phosphatase, receptor type, U isof... 1583 0.0
gi|110735402 protein tyrosine phosphatase, receptor type, U isof... 1577 0.0
gi|110735406 protein tyrosine phosphatase, receptor type, U isof... 1576 0.0
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 498 e-140
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 498 e-140
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 498 e-140
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 498 e-140
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 498 e-140
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 498 e-140
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 498 e-140
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 498 e-140
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 498 e-140
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 498 e-140
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 497 e-140
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 440 e-123
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 440 e-123
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 440 e-123
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 423 e-118
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo... 423 e-118
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 377 e-104
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 368 e-101
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 347 6e-95
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 347 6e-95
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 347 6e-95
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 3015 bits (7816), Expect = 0.0
Identities = 1465/1465 (100%), Positives = 1465/1465 (100%)
Query: 1 MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD 60
MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD
Sbjct: 1 MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD 60
Query: 61 PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV 120
PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV
Sbjct: 61 PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV 120
Query: 121 NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH 180
NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH
Sbjct: 121 NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH 180
Query: 181 PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR 240
PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR
Sbjct: 181 PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR 240
Query: 241 FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI 300
FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI
Sbjct: 241 FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI 300
Query: 301 QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE 360
QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE
Sbjct: 301 QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE 360
Query: 361 GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC 420
GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC
Sbjct: 361 GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC 420
Query: 421 YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED 480
YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED
Sbjct: 421 YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED 480
Query: 481 LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS 540
LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS
Sbjct: 481 LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS 540
Query: 541 KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT 600
KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT
Sbjct: 541 KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT 600
Query: 601 DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY 660
DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY
Sbjct: 601 DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY 660
Query: 661 FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA 720
FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA
Sbjct: 661 FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA 720
Query: 721 TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST 780
TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST
Sbjct: 721 TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST 780
Query: 781 RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY 840
RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY
Sbjct: 781 RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY 840
Query: 841 YPDPFVPTAILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQ 900
YPDPFVPTAILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQ
Sbjct: 841 YPDPFVPTAILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQ 900
Query: 901 HITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEG 960
HITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEG
Sbjct: 901 HITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEG 960
Query: 961 DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVK 1020
DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVK
Sbjct: 961 DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVK 1020
Query: 1021 CCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVP 1080
CCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVP
Sbjct: 1021 CCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVP 1080
Query: 1081 YHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCV 1140
YHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCV
Sbjct: 1081 YHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCV 1140
Query: 1141 RELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIK 1200
RELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIK
Sbjct: 1141 RELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIK 1200
Query: 1201 EEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAAL 1260
EEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAAL
Sbjct: 1201 EEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAAL 1260
Query: 1261 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRH 1320
MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRH
Sbjct: 1261 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRH 1320
Query: 1321 GPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKL 1380
GPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKL
Sbjct: 1321 GPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKL 1380
Query: 1381 IRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNN 1440
IRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNN
Sbjct: 1381 IRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNN 1440
Query: 1441 KPNMVDLLDQYKFCYEVALEYLNSG 1465
KPNMVDLLDQYKFCYEVALEYLNSG
Sbjct: 1441 KPNMVDLLDQYKFCYEVALEYLNSG 1465
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 2979 bits (7724), Expect = 0.0
Identities = 1452/1465 (99%), Positives = 1452/1465 (99%), Gaps = 13/1465 (0%)
Query: 1 MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD 60
MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD
Sbjct: 1 MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD 60
Query: 61 PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV 120
PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV
Sbjct: 61 PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV 120
Query: 121 NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH 180
NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH
Sbjct: 121 NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH 180
Query: 181 PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR 240
PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR
Sbjct: 181 PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR 240
Query: 241 FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI 300
FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI
Sbjct: 241 FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI 300
Query: 301 QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE 360
QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE
Sbjct: 301 QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE 360
Query: 361 GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC 420
GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC
Sbjct: 361 GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC 420
Query: 421 YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED 480
YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED
Sbjct: 421 YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED 480
Query: 481 LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS 540
LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS
Sbjct: 481 LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS 540
Query: 541 KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT 600
KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT
Sbjct: 541 KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT 600
Query: 601 DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY 660
DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY
Sbjct: 601 DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY 660
Query: 661 FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA 720
FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA
Sbjct: 661 FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA 720
Query: 721 TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST 780
TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST
Sbjct: 721 TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST 780
Query: 781 RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY 840
RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY
Sbjct: 781 RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY 840
Query: 841 YPDPFVPTAILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQ 900
YP DETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQ
Sbjct: 841 YP-------------DETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQ 887
Query: 901 HITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEG 960
HITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEG
Sbjct: 888 HITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEG 947
Query: 961 DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVK 1020
DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVK
Sbjct: 948 DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVK 1007
Query: 1021 CCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVP 1080
CCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVP
Sbjct: 1008 CCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVP 1067
Query: 1081 YHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCV 1140
YHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCV
Sbjct: 1068 YHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCV 1127
Query: 1141 RELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIK 1200
RELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIK
Sbjct: 1128 RELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIK 1187
Query: 1201 EEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAAL 1260
EEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAAL
Sbjct: 1188 EEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAAL 1247
Query: 1261 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRH 1320
MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRH
Sbjct: 1248 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRH 1307
Query: 1321 GPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKL 1380
GPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKL
Sbjct: 1308 GPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKL 1367
Query: 1381 IRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNN 1440
IRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNN
Sbjct: 1368 IRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNN 1427
Query: 1441 KPNMVDLLDQYKFCYEVALEYLNSG 1465
KPNMVDLLDQYKFCYEVALEYLNSG
Sbjct: 1428 KPNMVDLLDQYKFCYEVALEYLNSG 1452
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 1963 bits (5085), Expect = 0.0
Identities = 945/1460 (64%), Positives = 1147/1460 (78%), Gaps = 55/1460 (3%)
Query: 18 AAGETFSGGCLFDEPYSTCGYSQSEGDD-FNWEQVNTLTKPTSDPWMPSGSFMLVNASGR 76
A ++ +GGC FDE YS CGYS + G + F WEQ+NT KP D +P+GSFM+VN+SGR
Sbjct: 23 ARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDQAVPTGSFMMVNSSGR 82
Query: 77 PEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDP 136
GQ+AHLLLP LKENDTHCIDFHY+ SS+ S PG LNVYVKVN GP GNP+WN+SG
Sbjct: 83 ASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVV 142
Query: 137 TRTWNRAELAISTFWPNFYQVIFEVIT-SGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVE 195
T W +AELAISTFWP+FYQVIFE ++ GH GY+A+DEV+VL HPC + PHFLR+QNVE
Sbjct: 143 TEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVE 202
Query: 196 VNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDA 255
VN GQ ATFQC A G+ D+LWLQ + RD L +V + RRF A+ +V +T +R
Sbjct: 203 VNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSV 262
Query: 256 GKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVA 315
KYRC+IR++GG G+SNYAEL+VKEPP PIAPP+L +VGATYLWI+ NANSI GDGPI+
Sbjct: 263 SKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIIL 322
Query: 316 REVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTK 375
+EVEY T +G+W + VDS +YK+ HLDPD EYEI VLLTRPGEGGTG PGP L TRTK
Sbjct: 323 KEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTK 382
Query: 376 CADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSW 435
CADP+ GP+ +E+V++++RQ+T++WEPFGY VTRCHSYNLTV Y Y Q+ EEV
Sbjct: 383 CADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVI- 441
Query: 436 DTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTF 495
+SH +T+ L P+ + ++L+L NPEGR ES+EL+VQT+ED+PGAVP ESIQG F
Sbjct: 442 -QTSSH--YTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPF 498
Query: 496 EEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYP 555
EEKI++QW+ P +T GVITLYEI YKAV S DP DLS+Q G+V KL NETH LF GLYP
Sbjct: 499 EEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYP 558
Query: 556 GTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRG 615
GTTYSFTI+ASTAKGFGPP T + TKISAPSMP Y+ +TPLN+TD T+TVMLKPA SRG
Sbjct: 559 GTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRG 618
Query: 616 APVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQP 675
APVSVYQ+VV+EER +++++ +I++C+ VP+ ++NAS L+S +YFAAE +L QP
Sbjct: 619 APVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQP 678
Query: 676 FTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKP-VPEPE 734
FT+GDNKTYNGYWN PL P KSY IYFQA S+ANGETKI+CV++ATKGA+T EPE
Sbjct: 679 FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVEPE 738
Query: 735 KQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKR----------KLAKKRKETMSSTRQEM 784
KQ D+TVK+AGVIAG+L+F+II LGV+L +K+R KLAKK+KET S ++EM
Sbjct: 739 KQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREM 798
Query: 785 TVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDP 844
+ ++ + + DE FS + ++NG + S + T T
Sbjct: 799 GPVASADKPTTKLSASRNDEGFS-SSSQDVNGFTDGSRGELSQPTLT------------- 844
Query: 845 FVPTAILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQ 904
+Q+H Y+ +P ++ Y Q PAIRVADLLQHITQ
Sbjct: 845 ------------------------IQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQ 880
Query: 905 MKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNS 964
MK +GYGFKEEYE+ EGQ+A WD+AK+DENR KNRYGNII+YDHSRVRL ++GD +S
Sbjct: 881 MKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHS 940
Query: 965 DYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKY 1024
DYIN NYIDGYHRP HYIATQGPMQET+ DFWRM+W EN+ASI+MVTNLVEVGRVKC +Y
Sbjct: 941 DYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRY 1000
Query: 1025 WPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHAT 1084
WPDDTE+Y DIKVTLIETE LAEYVIRTF V+K+G HEIRE+R FHFT WPDHGVP +AT
Sbjct: 1001 WPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYAT 1060
Query: 1085 GLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELR 1144
GLLGFVRQVK +PP AGP+VVHCSAGAGRTGCFI ID MLDMAE EGVVDI+NCVRELR
Sbjct: 1061 GLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELR 1120
Query: 1145 SRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFR 1204
++RVN+VQTEEQYVF+HDAILEACLCG+T++P + RSLYY++++LDPQTNSSQIK+EF+
Sbjct: 1121 AQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQ 1180
Query: 1205 TLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSY 1264
TLN+VTP +R EDCSI LLPRNH+KNR MD+LP DRCLPFLI++DGESSNYINAALMDS+
Sbjct: 1181 TLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSH 1240
Query: 1265 KQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQ 1324
KQP+AF+VTQHPLPNTV DFWRLV DY+C+SVVMLN++D AQ C QYWPE +GPIQ
Sbjct: 1241 KQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQ 1300
Query: 1325 VEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQV 1384
VEFVSAD++EDII RIFRI N ARPQDGYR+VQ Q++GWP YRDTP SKRS LK++R++
Sbjct: 1301 VEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRL 1360
Query: 1385 DKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNM 1444
+KWQE+Y+G EGRTVVHCLNGGGRSGTFCAI VCEM++ Q +DVFH VKTLRNNK NM
Sbjct: 1361 EKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNM 1420
Query: 1445 VDLLDQYKFCYEVALEYLNS 1464
V+ L+QYKF YEVALEYL+S
Sbjct: 1421 VETLEQYKFVYEVALEYLSS 1440
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 1951 bits (5055), Expect = 0.0
Identities = 945/1479 (63%), Positives = 1147/1479 (77%), Gaps = 74/1479 (5%)
Query: 18 AAGETFSGGCLFDEPYSTCGYSQSEGDD-FNWEQVNTLTKPTSDPWMPSGSFMLVNASGR 76
A ++ +GGC FDE YS CGYS + G + F WEQ+NT KP D +P+GSFM+VN+SGR
Sbjct: 23 ARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDQAVPTGSFMMVNSSGR 82
Query: 77 PEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDP 136
GQ+AHLLLP LKENDTHCIDFHY+ SS+ S PG LNVYVKVN GP GNP+WN+SG
Sbjct: 83 ASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVV 142
Query: 137 TRTWNRAELAISTFWPNFYQVIFEVIT-SGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVE 195
T W +AELAISTFWP+FYQVIFE ++ GH GY+A+DEV+VL HPC + PHFLR+QNVE
Sbjct: 143 TEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVE 202
Query: 196 VNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDA 255
VN GQ ATFQC A G+ D+LWLQ + RD L +V + RRF A+ +V +T +R
Sbjct: 203 VNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSV 262
Query: 256 GKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVA 315
KYRC+IR++GG G+SNYAEL+VKEPP PIAPP+L +VGATYLWI+ NANSI GDGPI+
Sbjct: 263 SKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIIL 322
Query: 316 REVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTK 375
+EVEY T +G+W + VDS +YK+ HLDPD EYEI VLLTRPGEGGTG PGP L TRTK
Sbjct: 323 KEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTK 382
Query: 376 CADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSW 435
CADP+ GP+ +E+V++++RQ+T++WEPFGY VTRCHSYNLTV Y Y Q+ EEV
Sbjct: 383 CADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVI- 441
Query: 436 DTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTF 495
+SH +T+ L P+ + ++L+L NPEGR ES+EL+VQT+ED+PGAVP ESIQG F
Sbjct: 442 -QTSSH--YTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPF 498
Query: 496 EEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYP 555
EEKI++QW+ P +T GVITLYEI YKAV S DP DLS+Q G+V KL NETH LF GLYP
Sbjct: 499 EEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYP 558
Query: 556 GTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRG 615
GTTYSFTI+ASTAKGFGPP T + TKISAPSMP Y+ +TPLN+TD T+TVMLKPA SRG
Sbjct: 559 GTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRG 618
Query: 616 APVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQP 675
APVSVYQ+VV+EER +++++ +I++C+ VP+ ++NAS L+S +YFAAE +L QP
Sbjct: 619 APVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQP 678
Query: 676 FTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATK---GAATPKP--- 729
FT+GDNKTYNGYWN PL P KSY IYFQA S+ANGETKI+CV++ATK G+A P
Sbjct: 679 FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKAPMGSAQVTPGTP 738
Query: 730 --------------VPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKR-------- 767
EPEKQ D+TVK+AGVIAG+L+F+II LGV+L +K+R
Sbjct: 739 LCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSY 798
Query: 768 --KLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSF 825
KLAKK+KET S ++EM + ++ + + DE FS + ++NG + S
Sbjct: 799 YLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFS-SSSQDVNGFTDGSRGEL 857
Query: 826 TMKTNTLSTSVPNSYYPDPFVPTAILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQ 885
+ T T +Q+H Y+ +P ++ Y
Sbjct: 858 SQPTLT-------------------------------------IQTHPYRTCDPVEMSYP 880
Query: 886 TGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNI 945
Q PAIRVADLLQHITQMK +GYGFKEEYE+ EGQ+A WD+AK+DENR KNRYGNI
Sbjct: 881 RDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNI 940
Query: 946 IAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTA 1005
I+YDHSRVRL ++GD +SDYIN NYIDGYHRP HYIATQGPMQET+ DFWRM+W EN+A
Sbjct: 941 ISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSA 1000
Query: 1006 SIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIRE 1065
SI+MVTNLVEVGRVKC +YWPDDTE+Y DIKVTLIETE LAEYVIRTF V+K+G HEIRE
Sbjct: 1001 SIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRE 1060
Query: 1066 IRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIML 1125
+R FHFT WPDHGVP +ATGLLGFVRQVK +PP AGP+VVHCSAGAGRTGCFI ID ML
Sbjct: 1061 LRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTML 1120
Query: 1126 DMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYY 1185
DMAE EGVVDI+NCVRELR++RVN+VQTEEQYVF+HDAILEACLCG+T++P + RSLYY
Sbjct: 1121 DMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYY 1180
Query: 1186 DMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFL 1245
++++LDPQTNSSQIK+EF+TLN+VTP +R EDCSI LLPRNH+KNR MD+LP DRCLPFL
Sbjct: 1181 NISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFL 1240
Query: 1246 ITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA 1305
I++DGESSNYINAALMDS+KQP+AF+VTQHPLPNTV DFWRLV DY+C+SVVMLN++D A
Sbjct: 1241 ISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTA 1300
Query: 1306 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWP 1365
Q C QYWPE +GPIQVEFVSAD++EDII RIFRI N ARPQDGYR+VQ Q++GWP
Sbjct: 1301 QFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWP 1360
Query: 1366 MYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQ 1425
YRDTP SKRS LK++R+++KWQE+Y+G EGRTVVHCLNGGGRSGTFCAI VCEM++ Q
Sbjct: 1361 AYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQ 1420
Query: 1426 RTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464
+DVFH VKTLRNNK NMV+ L+QYKF YEVALEYL+S
Sbjct: 1421 NIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1459
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 1848 bits (4786), Expect = 0.0
Identities = 889/1458 (60%), Positives = 1096/1458 (75%), Gaps = 48/1458 (3%)
Query: 14 LLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNA 73
LL +A G+ +GGC FD+ C Y Q DDF W V+ P MP GS+M+V++
Sbjct: 23 LLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDS 82
Query: 74 SGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNIS 133
S G++A L LP +KENDTHCIDF Y + S+ PG LN+ V+VN GPL NPIWN++
Sbjct: 83 SDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVT 142
Query: 134 GDPTRTWNRAELAISTFWPNFYQVIFEV-ITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQ 192
G R W RAELA+STFWPN YQVIFE ++ G GY+AID+++VL +PC ++PHFLR+
Sbjct: 143 GFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLG 202
Query: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
+VEVNAGQ ATFQC A GR ++LWLQ + D P+ + K + RRF ASF + TK
Sbjct: 203 DVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTK 262
Query: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
D YRC+ ++E G G+SN+A+L+V+EPP PIAPPQL VG TYL IQLNANSI GDGP
Sbjct: 263 TDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGP 322
Query: 313 IVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRT 372
I+ +EVEY SGSW + V++ +YK+ HLDPDTEYEI VLLTRPGEGGTG PGP L T
Sbjct: 323 IILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLIT 382
Query: 373 RTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREE 432
RTKCA+PMR P+ L++ E+++R+I + WE GYN+TRCH++N+T+ Y Y G E +
Sbjct: 383 RTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADC 442
Query: 433 VSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQG 492
+ D + PQH + +L PYTNVS+K+IL NPEGRKES+E I+QTDED+PG VP +S+QG
Sbjct: 443 LDMDPKA--PQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQG 500
Query: 493 STFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFG 552
++FE KIFL W+EP G+IT YEI+Y ++ SFDP + ++ VS L N TH +F
Sbjct: 501 TSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMH 560
Query: 553 LYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYE-LETPLNQTDNTVTVMLKPA 611
L+PGTTY F IRAST KGFGP TT ISAP++P YE ++ LN+T T+TV+L+PA
Sbjct: 561 LHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPA 620
Query: 612 HSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQ 671
++GAP+S YQIVVEE P RTK+ ++CY VP+ +QNA + YYFAAE P +L
Sbjct: 621 QAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLP 680
Query: 672 AAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKP-- 729
PFT+GDN+TY G+WN PL P K Y IYFQA S ETK CV++ATK AAT +P
Sbjct: 681 EPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEV 740
Query: 730 VPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVN 789
+P+P KQTD VKIAG+ AGIL+F+++ L V+L++KK KLAKKRK+ M +TRQEMT MVN
Sbjct: 741 IPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVN 800
Query: 790 SMDKSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFV 846
+MD+SYA+Q T E + +FMD HN + R
Sbjct: 801 AMDRSYADQSTLHAEDPLSITFMDQHNFSPRY---------------------------- 832
Query: 847 PTAILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMK 906
E H+ +++S L+ Y E + PYQTGQLHPAIRVADLLQHI MK
Sbjct: 833 ----------ENHSATAESSRLLDVPRYLC-EGTESPYQTGQLHPAIRVADLLQHINLMK 881
Query: 907 CAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDY 966
++ YGFKEEYESFFEGQSA WD AKKD+NR KNRYGNIIAYDHSRV LQ +E D +SDY
Sbjct: 882 TSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDY 941
Query: 967 INGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWP 1026
IN NYIDGY RP+HYIATQGP+ ET+YDFWRM+W E +A I+MVTNLVEVGRVKC KYWP
Sbjct: 942 INANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP 1001
Query: 1027 DDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGL 1086
DDTE+Y D KVT +E E LAEYV+RTF +E+RG +EIRE++QFHFTGWPDHGVPYHATGL
Sbjct: 1002 DDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGL 1061
Query: 1087 LGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSR 1146
L F+R+VK +PPSAGP+VVHCSAGAGRTGC+IVIDIMLDMAEREGVVDIYNCV+ LRSR
Sbjct: 1062 LSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSR 1121
Query: 1147 RVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTL 1206
R+NMVQTEEQY+FIHDAILEACLCG+T++P + ++ Y+DM ++D QTNSS +K+EF+TL
Sbjct: 1122 RINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTL 1181
Query: 1207 NMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQ 1266
N VTP L+ EDCSIA LPRNH+KNR MD+LPPDRCLPFLITIDGESSNYINAALMDSY+Q
Sbjct: 1182 NSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQ 1241
Query: 1267 PSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVE 1326
P+AFIVTQ+PLPNTVKDFWRLV DY CTS+VMLN+VD +Q CPQYWPE G+ R+GPIQVE
Sbjct: 1242 PAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVE 1301
Query: 1327 FVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDK 1386
+S ++ D+I+RIFRI N RPQ+GY MVQQFQ+LGW +R+ P SKRSFLKLI QV+K
Sbjct: 1302 CMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEK 1361
Query: 1387 WQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVD 1446
WQEE GEGRT++HCLNGGGRSG FCAI IV EM++ Q VDVFHAVKTLRN+KPNMV+
Sbjct: 1362 WQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVE 1421
Query: 1447 LLDQYKFCYEVALEYLNS 1464
+QY+FCY+VALEYL S
Sbjct: 1422 APEQYRFCYDVALEYLES 1439
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 1841 bits (4769), Expect = 0.0
Identities = 889/1464 (60%), Positives = 1096/1464 (74%), Gaps = 54/1464 (3%)
Query: 14 LLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNA 73
LL +A G+ +GGC FD+ C Y Q DDF W V+ P MP GS+M+V++
Sbjct: 23 LLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDS 82
Query: 74 SGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNIS 133
S G++A L LP +KENDTHCIDF Y + S+ PG LN+ V+VN GPL NPIWN++
Sbjct: 83 SDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVT 142
Query: 134 GDPTRTWNRAELAISTFWPNFYQVIFEV-ITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQ 192
G R W RAELA+STFWPN YQVIFE ++ G GY+AID+++VL +PC ++PHFLR+
Sbjct: 143 GFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLG 202
Query: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
+VEVNAGQ ATFQC A GR ++LWLQ + D P+ + K + RRF ASF + TK
Sbjct: 203 DVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTK 262
Query: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
D YRC+ ++E G G+SN+A+L+V+EPP PIAPPQL VG TYL IQLNANSI GDGP
Sbjct: 263 TDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGP 322
Query: 313 IVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRT 372
I+ +EVEY SGSW + V++ +YK+ HLDPDTEYEI VLLTRPGEGGTG PGP L T
Sbjct: 323 IILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLIT 382
Query: 373 RTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREE 432
RTKCA+PMR P+ L++ E+++R+I + WE GYN+TRCH++N+T+ Y Y G E +
Sbjct: 383 RTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADC 442
Query: 433 VSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQG 492
+ D + PQH + +L PYTNVS+K+IL NPEGRKES+E I+QTDED+PG VP +S+QG
Sbjct: 443 LDMDPKA--PQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQG 500
Query: 493 STFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFG 552
++FE KIFL W+EP G+IT YEI+Y ++ SFDP + ++ VS L N TH +F
Sbjct: 501 TSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMH 560
Query: 553 LYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYE-LETPLNQTDNTVTVMLKPA 611
L+PGTTY F IRAST KGFGP TT ISAP++P YE ++ LN+T T+TV+L+PA
Sbjct: 561 LHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPA 620
Query: 612 HSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQ 671
++GAP+S YQIVVEE P RTK+ ++CY VP+ +QNA + YYFAAE P +L
Sbjct: 621 QAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLP 680
Query: 672 AAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKP-- 729
PFT+GDN+TY G+WN PL P K Y IYFQA S ETK CV++ATK AAT +P
Sbjct: 681 EPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEV 740
Query: 730 VPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVN 789
+P+P KQTD VKIAG+ AGIL+F+++ L V+L++KK KLAKKRK+ M +TRQEMT MVN
Sbjct: 741 IPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVN 800
Query: 790 SMDKSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFV 846
+MD+SYA+Q T E + +FMD HN + R
Sbjct: 801 AMDRSYADQSTLHAEDPLSITFMDQHNFSPRY---------------------------- 832
Query: 847 PTAILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMK 906
E H+ +++S L+ Y E + PYQTGQLHPAIRVADLLQHI MK
Sbjct: 833 ----------ENHSATAESSRLLDVPRYLC-EGTESPYQTGQLHPAIRVADLLQHINLMK 881
Query: 907 CAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDY 966
++ YGFKEEYESFFEGQSA WD AKKD+NR KNRYGNIIAYDHSRV LQ +E D +SDY
Sbjct: 882 TSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDY 941
Query: 967 INGNYID------GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVK 1020
IN NYID GY RP+HYIATQGP+ ET+YDFWRM+W E +A I+MVTNLVEVGRVK
Sbjct: 942 INANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVK 1001
Query: 1021 CCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVP 1080
C KYWPDDTE+Y D KVT +E E LAEYV+RTF +E+RG +EIRE++QFHFTGWPDHGVP
Sbjct: 1002 CYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVP 1061
Query: 1081 YHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCV 1140
YHATGLL F+R+VK +PPSAGP+VVHCSAGAGRTGC+IVIDIMLDMAEREGVVDIYNCV
Sbjct: 1062 YHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCV 1121
Query: 1141 RELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIK 1200
+ LRSRR+NMVQTEEQY+FIHDAILEACLCG+T++P + ++ Y+DM ++D QTNSS +K
Sbjct: 1122 KALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLK 1181
Query: 1201 EEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAAL 1260
+EF+TLN VTP L+ EDCSIA LPRNH+KNR MD+LPPDRCLPFLITIDGESSNYINAAL
Sbjct: 1182 DEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAAL 1241
Query: 1261 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRH 1320
MDSY+QP+AFIVTQ+PLPNTVKDFWRLV DY CTS+VMLN+VD +Q CPQYWPE G+ R+
Sbjct: 1242 MDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRY 1301
Query: 1321 GPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKL 1380
GPIQVE +S ++ D+I+RIFRI N RPQ+GY MVQQFQ+LGW +R+ P SKRSFLKL
Sbjct: 1302 GPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKL 1361
Query: 1381 IRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNN 1440
I QV+KWQEE GEGRT++HCLNGGGRSG FCAI IV EM++ Q VDVFHAVKTLRN+
Sbjct: 1362 ILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNS 1421
Query: 1441 KPNMVDLLDQYKFCYEVALEYLNS 1464
KPNMV+ +QY+FCY+VALEYL S
Sbjct: 1422 KPNMVEAPEQYRFCYDVALEYLES 1445
>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
precursor [Homo sapiens]
Length = 1436
Score = 1583 bits (4098), Expect = 0.0
Identities = 771/1456 (52%), Positives = 1019/1456 (69%), Gaps = 60/1456 (4%)
Query: 21 ETFSGGCLFDE---PYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRP 77
ET + GC F+E P C YSQ++ DDF WEQV + +P GS+++VN S
Sbjct: 21 ETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHA 80
Query: 78 EGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPT 137
GQRAH++ L ENDTHC+ F YF+ S+ PG L VYV+VN GPLG+ +WN++G
Sbjct: 81 PGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHG 140
Query: 138 RTWNRAELAISTFWPNFYQVIFEVITS-GHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEV 196
R W++AELA+STFWPN YQV+FE + S +GY+ +D++ +L +PC + PHF R+ +VEV
Sbjct: 141 RQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEV 200
Query: 197 NAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAG 256
NAGQ A+FQC A GR +R LQ P ++ S RRF+A+F + ++ +
Sbjct: 201 NAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQD 260
Query: 257 KYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAR 316
YRC+ + G G+SN+AEL+VKEPP PIAPPQL G TYL IQLN NSI GDGPIV +
Sbjct: 261 LYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRK 320
Query: 317 EVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKC 376
E+EY A G W + V +YK+ HLDPDTEYEISVLLTRPG+GGTG PGP L +RTKC
Sbjct: 321 EIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKC 380
Query: 377 ADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQ--EQVREEVS 434
A+PMR P+ L E+++RQ+T++WEP GYNVTRCH+Y +++ Y Y +G + +RE V
Sbjct: 381 AEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440
Query: 435 WDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGST 494
TE ++TI NL PY NV V+L+L NPEGRKE +E+ QTDED+P + ES+ +
Sbjct: 441 --TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
Query: 495 FEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLY 554
E+ IFL+W EP + G+IT YEI+Y+++ S DP +++ +SKL NET+ +F L+
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
Query: 555 PGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614
PGTTY F++RA T KGFG A + TT ISAPS ++ +PL +++NT+TV+L+PA R
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGR 618
Query: 615 GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQ 674
GAP+SVYQ++VEEER RR ++ C+PVP+ F+ A +YF AE A SL A
Sbjct: 619 GAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAM 678
Query: 675 PFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKPVP-EP 733
PFT+GDN+TY G+WN PL P K+Y IYFQAAS GET+++C+++A K A P E
Sbjct: 679 PFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEV 738
Query: 734 EKQTDHTVKIAGVIAGILLFVIIFLG-VVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMD 792
++++ I G+ AG L +I+ LG ++++++K K K T++ RQE T M++++D
Sbjct: 739 SQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNY-RQEKTHMMSAVD 797
Query: 793 KSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTA 849
+S+ +Q T ++ SFMDTH + R
Sbjct: 798 RSFTDQSTLQEDERLGLSFMDTHGYSTRG------------------------------- 826
Query: 850 ILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAE 909
D+ ++ SSL+ + PY TGQLHPA+RVADLLQHI QMK AE
Sbjct: 827 ------DQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAE 880
Query: 910 GYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYING 969
GYGFK+EYESFFEG WD+ KK + +R + AYD RV+L + GD N+DYIN
Sbjct: 881 GYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINA 936
Query: 970 NYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDT 1029
NYIDGYHR NH+IATQGP E +YDFWRMVW E+ +SI+M+T LVEVGRVKC +YWP+D+
Sbjct: 937 NYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDS 996
Query: 1030 EIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGF 1089
+ Y DIK+ L++TE LAEYV+RTFA+E+RG E+RQFHFT WP+HGVPYHATGLL F
Sbjct: 997 DTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAF 1056
Query: 1090 VRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVN 1149
+R+VK+ +PP AGP+V+HCSAG GRTGC+IV+D+MLDMAE EGVVDIYNCV+ L SRRVN
Sbjct: 1057 IRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVN 1116
Query: 1150 MVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMV 1209
M+QTEEQY+FIHDAILEACLCG+T++P S+ ++ Y +M ++DPQ+NSSQ++EEF+TLN V
Sbjct: 1117 MIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSV 1176
Query: 1210 TPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSA 1269
TP L VE+CSIALLPRN +KNR MD+LPPDRCLPFLI+ DG+S+NYINAAL DSY + +A
Sbjct: 1177 TPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAA 1236
Query: 1270 FIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV---DPAQLCPQYWPENGVHRHGPIQVE 1326
FIVT HPL +T DFWRLV DY CTS+VMLN + + A C QYWPE G ++G ++VE
Sbjct: 1237 FIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVE 1296
Query: 1327 FVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDK 1386
F+S +ED+++R+FR+ N +R Q+G+ +V+ FQFL W YRDTP SK++FL L+ +VDK
Sbjct: 1297 FMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDK 1356
Query: 1387 WQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVD 1446
WQ E G+GRT+VHCLNGGGRSGTFCA + V EM+R VDVF A KTLRN KPNMV+
Sbjct: 1357 WQAE--SGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVE 1414
Query: 1447 LLDQYKFCYEVALEYL 1462
+DQY FCY+VALEYL
Sbjct: 1415 TMDQYHFCYDVALEYL 1430
>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
precursor [Homo sapiens]
Length = 1446
Score = 1577 bits (4083), Expect = 0.0
Identities = 771/1466 (52%), Positives = 1018/1466 (69%), Gaps = 70/1466 (4%)
Query: 21 ETFSGGCLFDE---PYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRP 77
ET + GC F+E P C YSQ++ DDF WEQV + +P GS+++VN S
Sbjct: 21 ETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHA 80
Query: 78 EGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPT 137
GQRAH++ L ENDTHC+ F YF+ S+ PG L VYV+VN GPLG+ +WN++G
Sbjct: 81 PGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHG 140
Query: 138 RTWNRAELAISTFWPNFYQVIFEVITS-GHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEV 196
R W++AELA+STFWPN YQV+FE + S +GY+ +D++ +L +PC + PHF R+ +VEV
Sbjct: 141 RQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEV 200
Query: 197 NAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAG 256
NAGQ A+FQC A GR +R LQ P ++ S RRF+A+F + ++ +
Sbjct: 201 NAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQD 260
Query: 257 KYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAR 316
YRC+ + G G+SN+AEL+VKEPP PIAPPQL G TYL IQLN NSI GDGPIV +
Sbjct: 261 LYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRK 320
Query: 317 EVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKC 376
E+EY A G W + V +YK+ HLDPDTEYEISVLLTRPG+GGTG PGP L +RTKC
Sbjct: 321 EIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKC 380
Query: 377 ADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQ--EQVREEVS 434
A+PMR P+ L E+++RQ+T++WEP GYNVTRCH+Y +++ Y Y +G + +RE V
Sbjct: 381 AEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440
Query: 435 WDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGST 494
TE ++TI NL PY NV V+L+L NPEGRKE +E+ QTDED+P + ES+ +
Sbjct: 441 --TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
Query: 495 FEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLY 554
E+ IFL+W EP + G+IT YEI+Y+++ S DP +++ +SKL NET+ +F L+
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
Query: 555 PGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614
PGTTY F++RA T KGFG A + TT ISAPS ++ +PL +++NT+TV+L+PA R
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGR 618
Query: 615 GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQ 674
GAP+SVYQ++VEEER RR ++ C+PVP+ F+ A +YF AE A SL A
Sbjct: 619 GAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAM 678
Query: 675 PFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKPVP-EP 733
PFT+GDN+TY G+WN PL P K+Y IYFQAAS GET+++C+++A K A P E
Sbjct: 679 PFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEV 738
Query: 734 EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKR-----------KLAKKRKETMSSTRQ 782
++++ I G+ AG L +I+ LG ++V+ ++ K K T++ RQ
Sbjct: 739 SQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYPKPVNMTKATVNY-RQ 797
Query: 783 EMTVMVNSMDKSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNS 839
E T M++++D+S+ +Q T ++ SFMDTH + R
Sbjct: 798 EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRG--------------------- 836
Query: 840 YYPDPFVPTAILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLL 899
D+ ++ SSL+ + PY TGQLHPA+RVADLL
Sbjct: 837 ----------------DQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLL 880
Query: 900 QHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIE 959
QHI QMK AEGYGFK+EYESFFEG WD+ KK + +R + AYD RV+L +
Sbjct: 881 QHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPML 936
Query: 960 GDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRV 1019
GD N+DYIN NYIDGYHR NH+IATQGP E +YDFWRMVW E+ +SI+M+T LVEVGRV
Sbjct: 937 GDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRV 996
Query: 1020 KCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGV 1079
KC +YWP+D++ Y DIK+ L++TE LAEYV+RTFA+E+RG E+RQFHFT WP+HGV
Sbjct: 997 KCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGV 1056
Query: 1080 PYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNC 1139
PYHATGLL F+R+VK+ +PP AGP+V+HCSAG GRTGC+IV+D+MLDMAE EGVVDIYNC
Sbjct: 1057 PYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNC 1116
Query: 1140 VRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQI 1199
V+ L SRRVNM+QTEEQY+FIHDAILEACLCG+T++P S+ ++ Y +M ++DPQ+NSSQ+
Sbjct: 1117 VKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQL 1176
Query: 1200 KEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAA 1259
+EEF+TLN VTP L VE+CSIALLPRN +KNR MD+LPPDRCLPFLI+ DG+S+NYINAA
Sbjct: 1177 REEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAA 1236
Query: 1260 LMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV---DPAQLCPQYWPENG 1316
L DSY + +AFIVT HPL +T DFWRLV DY CTS+VMLN + + A C QYWPE G
Sbjct: 1237 LTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPG 1296
Query: 1317 VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRS 1376
++G ++VEF+S +ED+++R+FR+ N +R Q+G+ +V+ FQFL W YRDTP SK++
Sbjct: 1297 RQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKA 1356
Query: 1377 FLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKT 1436
FL L+ +VDKWQ E G+GRT+VHCLNGGGRSGTFCA + V EM+R VDVF A KT
Sbjct: 1357 FLHLLAEVDKWQAE--SGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKT 1414
Query: 1437 LRNNKPNMVDLLDQYKFCYEVALEYL 1462
LRN KPNMV+ +DQY FCY+VALEYL
Sbjct: 1415 LRNYKPNMVETMDQYHFCYDVALEYL 1440
>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
precursor [Homo sapiens]
Length = 1442
Score = 1576 bits (4081), Expect = 0.0
Identities = 771/1462 (52%), Positives = 1019/1462 (69%), Gaps = 66/1462 (4%)
Query: 21 ETFSGGCLFDE---PYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRP 77
ET + GC F+E P C YSQ++ DDF WEQV + +P GS+++VN S
Sbjct: 21 ETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHA 80
Query: 78 EGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPT 137
GQRAH++ L ENDTHC+ F YF+ S+ PG L VYV+VN GPLG+ +WN++G
Sbjct: 81 PGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHG 140
Query: 138 RTWNRAELAISTFWPNFYQVIFEVITS-GHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEV 196
R W++AELA+STFWPN YQV+FE + S +GY+ +D++ +L +PC + PHF R+ +VEV
Sbjct: 141 RQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEV 200
Query: 197 NAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAG 256
NAGQ A+FQC A GR +R LQ P ++ S RRF+A+F + ++ +
Sbjct: 201 NAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQD 260
Query: 257 KYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAR 316
YRC+ + G G+SN+AEL+VKEPP PIAPPQL G TYL IQLN NSI GDGPIV +
Sbjct: 261 LYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRK 320
Query: 317 EVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKC 376
E+EY A G W + V +YK+ HLDPDTEYEISVLLTRPG+GGTG PGP L +RTKC
Sbjct: 321 EIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKC 380
Query: 377 ADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQ--EQVREEVS 434
A+PMR P+ L E+++RQ+T++WEP GYNVTRCH+Y +++ Y Y +G + +RE V
Sbjct: 381 AEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440
Query: 435 WDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGST 494
TE ++TI NL PY NV V+L+L NPEGRKE +E+ QTDED+P + ES+ +
Sbjct: 441 --TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498
Query: 495 FEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLY 554
E+ IFL+W EP + G+IT YEI+Y+++ S DP +++ +SKL NET+ +F L+
Sbjct: 499 LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558
Query: 555 PGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614
PGTTY F++RA T KGFG A + TT ISAPS ++ +PL +++NT+TV+L+PA R
Sbjct: 559 PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGR 618
Query: 615 GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQ 674
GAP+SVYQ++VEEER RR ++ C+PVP+ F+ A +YF AE A SL A
Sbjct: 619 GAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAM 678
Query: 675 PFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKPVP-EP 733
PFT+GDN+TY G+WN PL P K+Y IYFQAAS GET+++C+++A K A P E
Sbjct: 679 PFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEV 738
Query: 734 EKQTDHTVKIAGVIAGILLFVIIFLG-VVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMD 792
++++ I G+ AG L +I+ LG ++++++K K K T++ RQE T M++++D
Sbjct: 739 SQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATVNY-RQEKTHMMSAVD 797
Query: 793 KSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTA 849
+S+ +Q T ++ SFMDTH + R
Sbjct: 798 RSFTDQSTLQEDERLGLSFMDTHGYSTRG------------------------------- 826
Query: 850 ILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAE 909
D+ ++ SSL+ + PY TGQLHPA+RVADLLQHI QMK AE
Sbjct: 827 ------DQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAE 880
Query: 910 GYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYING 969
GYGFK+EYESFFEG WD+ KK + +R + AYD RV+L + GD N+DYIN
Sbjct: 881 GYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINA 936
Query: 970 NYID------GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCK 1023
NYID GYHR NH+IATQGP E +YDFWRMVW E+ +SI+M+T LVEVGRVKC +
Sbjct: 937 NYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSR 996
Query: 1024 YWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHA 1083
YWP+D++ Y DIK+ L++TE LAEYV+RTFA+E+RG E+RQFHFT WP+HGVPYHA
Sbjct: 997 YWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHA 1056
Query: 1084 TGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVREL 1143
TGLL F+R+VK+ +PP AGP+V+HCSAG GRTGC+IV+D+MLDMAE EGVVDIYNCV+ L
Sbjct: 1057 TGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTL 1116
Query: 1144 RSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEF 1203
SRRVNM+QTEEQY+FIHDAILEACLCG+T++P S+ ++ Y +M ++DPQ+NSSQ++EEF
Sbjct: 1117 CSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEF 1176
Query: 1204 RTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDS 1263
+TLN VTP L VE+CSIALLPRN +KNR MD+LPPDRCLPFLI+ DG+S+NYINAAL DS
Sbjct: 1177 QTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDS 1236
Query: 1264 YKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV---DPAQLCPQYWPENGVHRH 1320
Y + +AFIVT HPL +T DFWRLV DY CTS+VMLN + + A C QYWPE G ++
Sbjct: 1237 YTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQY 1296
Query: 1321 GPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKL 1380
G ++VEF+S +ED+++R+FR+ N +R Q+G+ +V+ FQFL W YRDTP SK++FL L
Sbjct: 1297 GLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHL 1356
Query: 1381 IRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNN 1440
+ +VDKWQ E G+GRT+VHCLNGGGRSGTFCA + V EM+R VDVF A KTLRN
Sbjct: 1357 LAEVDKWQAE--SGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNY 1414
Query: 1441 KPNMVDLLDQYKFCYEVALEYL 1462
KPNMV+ +DQY FCY+VALEYL
Sbjct: 1415 KPNMVETMDQYHFCYDVALEYL 1436
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 498 bits (1283), Expect = e-140
Identities = 276/609 (45%), Positives = 373/609 (61%), Gaps = 16/609 (2%)
Query: 864 DTSSLVQSHTYKKREPADVPYQT-GQL-HPAIRVADLLQHITQMKCAEGYGFKEEYESFF 921
+ + L H E + +QT G L HP I +AD+ +H ++K + +EYES
Sbjct: 899 NNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 958
Query: 922 EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY 981
GQ W+ + + N+ KNRY N+IAYDHSRV LQ IEG SDYIN NY+DGY N Y
Sbjct: 959 PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1018
Query: 982 IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLI 1040
IATQGP+ ET DFWRMVW + +A+I+M+T L E R+KC +YWP+ TE Y I+VTL+
Sbjct: 1019 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1078
Query: 1041 ETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPS 1100
+T LA + +RTF++ K G E RE+RQF FT WPDHGVP + T L F+R+VK+ +PP
Sbjct: 1079 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1138
Query: 1101 AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFI 1160
AGP+VVHCSAG GRTGCFIVID ML+ + E VD+Y V +RS+R MVQTE+QY FI
Sbjct: 1139 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1198
Query: 1161 HDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTL-NMVTPTLRVEDCS 1219
H+A+LEA CG+T VPA + + + +++P + + ++ EF+ L N T R
Sbjct: 1199 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS-- 1256
Query: 1220 IALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLP 1278
A LP N KNR ++I+P + L I G E S+YINA+ +D Y+Q A+I TQ PL
Sbjct: 1257 -ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1315
Query: 1279 NTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDI 1336
T +DFWR++ + + T VVML + + C QYWP R Q V E ++
Sbjct: 1316 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNM 1372
Query: 1337 ISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGE 1395
I R + +DG R V+QFQF WP + P S F+ I QV K +E++ G +
Sbjct: 1373 PQYILREFKVTDARDGQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQD 1430
Query: 1396 GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCY 1455
G VHC G GR+G F +SIV E +R++ VD+F VK LR +P MV D+Y+FCY
Sbjct: 1431 GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1490
Query: 1456 EVALEYLNS 1464
+ ALEYL S
Sbjct: 1491 QAALEYLGS 1499
Score = 133 bits (334), Expect = 1e-30
Identities = 83/243 (34%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284
N KNR +++ D L I+G S+YINA +D Y+ +A+I TQ PLP T DF
Sbjct: 973 NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF 1032
Query: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342
WR+V + ++VM+ ++ C QYWP G +G IQV + R F
Sbjct: 1033 WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFS 1092
Query: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402
++ + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1093 LHKNGSSEK--REVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNPP---DAGPIVVHC 1146
Query: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462
G GR+G F I + E ++ ++TVDV+ V +R+ + MV DQY F +E LE +
Sbjct: 1147 SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1206
Query: 1463 NSG 1465
G
Sbjct: 1207 GCG 1209
Score = 77.0 bits (188), Expect = 1e-13
Identities = 97/400 (24%), Positives = 167/400 (41%), Gaps = 43/400 (10%)
Query: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK-R 253
E+ G C A+G + + W+QG + +T NV+ T +
Sbjct: 246 EIMPGGNVNITCVAVGSPMPYVK-WMQGAE---------DLTPEDDMPVGRNVLELTDVK 295
Query: 254 DAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPI 313
D+ Y C+ + GV I A++ VK P P + AT + I ++ + + P+
Sbjct: 296 DSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPD---PV 351
Query: 314 VAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALR 371
+EY + S G + ++ + +T Y IG L P++EYEI V + G G P ++
Sbjct: 352 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVV 409
Query: 372 TRTKCADPMRGPRKLEVVEVKSRQITIRW-EPFGYN-VTRCHSYNLTVHYCYQVGGQEQV 429
TRT P PR ++ + + + ++W EP N + R + T+ + VG ++
Sbjct: 410 TRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKH 469
Query: 430 REEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTE 488
+ S T T+ +L +V+++ G S + V+T + +PG P
Sbjct: 470 NVDDSLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMN 521
Query: 489 SIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHF 548
+ E I L W P Q I YE+ ++ E D + GR T +
Sbjct: 522 LRAEARSETSITLSWSPPRQE--SIIKYELLFR-------EGDHGREVGRT--FDPTTSY 570
Query: 549 LFFGLYPGTTYSFTIRASTAKGFG--PPATNQFTTKISAP 586
+ L P T Y+F + A + +G G P Q T + +P
Sbjct: 571 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISP 610
Score = 55.5 bits (132), Expect = 4e-07
Identities = 111/482 (23%), Positives = 174/482 (36%), Gaps = 75/482 (15%)
Query: 325 GSWNDRQPVDSTSYKIGHLDPDTEYEISVL-LTRPGEGGTGSPGPALRTRTKCADPMRGP 383
G+W DS +G L D Y + VL T G+G P ++ +T+ P + P
Sbjct: 464 GNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDP---IQVKTQQGVPGQ-P 519
Query: 384 RKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVG--GQEQVREEVSWDTENSH 441
L IT+ W P R S + ++ G G+E R T +
Sbjct: 520 MNLRAEARSETSITLSWSP-----PRQESI-IKYELLFREGDHGREVGR------TFDPT 567
Query: 442 PQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFL 501
+ + +L P T + +L +P+G ++ Q L P + + L
Sbjct: 568 TSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQ--RTLQSISPKNFKVKMIMKTSVLL 625
Query: 502 QWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSF 561
W P Y T Y+I Y ++ ++D G T L L P T Y+F
Sbjct: 626 SWEFP-DNYNSPTPYKIQYNGLTL---DVD-----------GRTTKKLITHLKPHTFYNF 670
Query: 562 TI--RASTAKGFGPPAT--NQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAP 617
+ R S+ G T F PS+ P D + V L S P
Sbjct: 671 VLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQSP-VP 723
Query: 618 VSVYQIVVEEERPRR---------TKKTTEILKCYPVPIHFQNASLLNSQY------YFA 662
V Y IV+ R R + + ++ + Q SL +S+ Y A
Sbjct: 724 VQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIA 783
Query: 663 AEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATK 722
A F F GD K Y G+ N L P Y ++ A + + T A
Sbjct: 784 ARFSV----LPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT------FAAS 833
Query: 723 GAATPKPV--PEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKETMSS 779
+ P + P+P+ D + VI +L V II + + +++ K K KRK++
Sbjct: 834 PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR 893
Query: 780 TR 781
T+
Sbjct: 894 TK 895
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 498 bits (1283), Expect = e-140
Identities = 276/609 (45%), Positives = 373/609 (61%), Gaps = 16/609 (2%)
Query: 864 DTSSLVQSHTYKKREPADVPYQT-GQL-HPAIRVADLLQHITQMKCAEGYGFKEEYESFF 921
+ + L H E + +QT G L HP I +AD+ +H ++K + +EYES
Sbjct: 1304 NNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 1363
Query: 922 EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY 981
GQ W+ + + N+ KNRY N+IAYDHSRV LQ IEG SDYIN NY+DGY N Y
Sbjct: 1364 PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1423
Query: 982 IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLI 1040
IATQGP+ ET DFWRMVW + +A+I+M+T L E R+KC +YWP+ TE Y I+VTL+
Sbjct: 1424 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1483
Query: 1041 ETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPS 1100
+T LA + +RTF++ K G E RE+RQF FT WPDHGVP + T L F+R+VK+ +PP
Sbjct: 1484 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1543
Query: 1101 AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFI 1160
AGP+VVHCSAG GRTGCFIVID ML+ + E VD+Y V +RS+R MVQTE+QY FI
Sbjct: 1544 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1603
Query: 1161 HDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTL-NMVTPTLRVEDCS 1219
H+A+LEA CG+T VPA + + + +++P + + ++ EF+ L N T R
Sbjct: 1604 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS-- 1661
Query: 1220 IALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLP 1278
A LP N KNR ++I+P + L I G E S+YINA+ +D Y+Q A+I TQ PL
Sbjct: 1662 -ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1720
Query: 1279 NTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDI 1336
T +DFWR++ + + T VVML + + C QYWP R Q V E ++
Sbjct: 1721 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNM 1777
Query: 1337 ISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGE 1395
I R + +DG R V+QFQF WP + P S F+ I QV K +E++ G +
Sbjct: 1778 PQYILREFKVTDARDGQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQD 1835
Query: 1396 GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCY 1455
G VHC G GR+G F +SIV E +R++ VD+F VK LR +P MV D+Y+FCY
Sbjct: 1836 GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1895
Query: 1456 EVALEYLNS 1464
+ ALEYL S
Sbjct: 1896 QAALEYLGS 1904
Score = 133 bits (334), Expect = 1e-30
Identities = 83/243 (34%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284
N KNR +++ D L I+G S+YINA +D Y+ +A+I TQ PLP T DF
Sbjct: 1378 NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF 1437
Query: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342
WR+V + ++VM+ ++ C QYWP G +G IQV + R F
Sbjct: 1438 WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFS 1497
Query: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402
++ + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1498 LHKNGSSEK--REVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNPP---DAGPIVVHC 1551
Query: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462
G GR+G F I + E ++ ++TVDV+ V +R+ + MV DQY F +E LE +
Sbjct: 1552 SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1611
Query: 1463 NSG 1465
G
Sbjct: 1612 GCG 1614
Score = 79.3 bits (194), Expect = 2e-14
Identities = 100/408 (24%), Positives = 172/408 (42%), Gaps = 44/408 (10%)
Query: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK-R 253
E+ G C A+G + + W+QG + +T NV+ T +
Sbjct: 242 EIMPGGNVNITCVAVGSPMPYVK-WMQGAE---------DLTPEDDMPVGRNVLELTDVK 291
Query: 254 DAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPI 313
D+ Y C+ + GV I A++ VK P P + AT + I ++ + + P+
Sbjct: 292 DSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPD---PV 347
Query: 314 VAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALR 371
+EY + S G + ++ + +T Y IG L P++EYEI V + G G P ++
Sbjct: 348 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVV 405
Query: 372 TRTKCADPMRGPRKLEVVEVKSRQITIRW-EPFGYN-VTRCHSYNLTVHYCYQVGGQEQV 429
TRT P PR ++ + + + ++W EP N + R + T+ + VG ++
Sbjct: 406 TRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKH 465
Query: 430 REEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTE 488
+ S T T+ +L +V+++ G S + V+T + +PG P
Sbjct: 466 NVDDSLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMN 517
Query: 489 SIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHF 548
+ E I L W P Q I YE+ ++ E D + GR T +
Sbjct: 518 LRAEARSETSITLSWSPPRQE--SIIKYELLFR-------EGDHGREVGRT--FDPTTSY 566
Query: 549 LFFGLYPGTTYSFTIRASTAKGFG--PPATNQFTTKISAPSMPAYELE 594
+ L P T Y+F + A + +G G P Q T + S PS P +++
Sbjct: 567 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ-SKPSAPPQDVK 613
Score = 70.1 bits (170), Expect = 1e-11
Identities = 64/245 (26%), Positives = 104/245 (42%), Gaps = 18/245 (7%)
Query: 335 STSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSR 394
+TSY + L P+TEY + P G G+ P +R RT + P P+ ++ V V+S
Sbjct: 563 TTSYVVEDLKPNTEYAFRLAARSPQ--GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRST 620
Query: 395 QITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTN 454
I + W P +V Y +G ++ +EV+ + Q + L +T
Sbjct: 621 AILVSWRPPPPETHNGALVGYSVRY-RPLGSEDPEPKEVN-GIPPTTTQILLEALEKWTQ 678
Query: 455 VSVKLILMNPEG-RKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYG 511
+ + G ES ++V+TDED+P A P + + I + WR P + +G
Sbjct: 679 YRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHG 738
Query: 512 VITLYEITYKAVSSFD----PEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRAST 567
I Y++ Y + + P I + L + + L P T YS T+ A T
Sbjct: 739 QIRGYQVHYVRMEGAEARGPPRI-------KDVMLADAQEMVITNLQPETAYSITVAAYT 791
Query: 568 AKGFG 572
KG G
Sbjct: 792 MKGDG 796
Score = 57.0 bits (136), Expect = 1e-07
Identities = 78/332 (23%), Positives = 119/332 (35%), Gaps = 42/332 (12%)
Query: 264 TEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSIN----------GDGPI 313
TE G G + +V + VP APP+ A LNA +I G I
Sbjct: 687 TEVGPGPESSPVVVRTDEDVPSAPPRKVEAEA------LNATAIRVLWRSPAPGRQHGQI 740
Query: 314 VAREVEYCTASGSWNDRQP-------VDSTSYKIGHLDPDTEYEISVLL-TRPGEGGTGS 365
+V Y G+ P D+ I +L P+T Y I+V T G+G
Sbjct: 741 RGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSK 800
Query: 366 PGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEP-FGYNVTRCHSYNLTVHYCYQVG 424
P + TK A + G L V + + RWEP G + Y L
Sbjct: 801 PKVVV---TKGA--VLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQF------- 848
Query: 425 GQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGA 484
G+E + + S ++T + + +L + G E ++ ED P
Sbjct: 849 GREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRG 908
Query: 485 VPTE-SIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSK 541
P G+ + L+W P + G I Y + + + P + + ++
Sbjct: 909 HPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARE--TELPAAAE 966
Query: 542 LGNETHFLFFGLYPGTTYSFTIRASTAKGFGP 573
G E GL P T Y +RA T +G GP
Sbjct: 967 PGAENALTLQGLKPDTAYDLQVRAHTRRGPGP 998
Score = 53.9 bits (128), Expect = 1e-06
Identities = 77/321 (23%), Positives = 121/321 (37%), Gaps = 34/321 (10%)
Query: 332 PVDSTSYKIGHLDPDTEYEISVLL-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVE 390
P +T + L+ T+Y I+ + T G G SP + RT P PRK+E
Sbjct: 662 PPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSP---VVVRTDEDVPSAPPRKVEAEA 718
Query: 391 VKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVG----GQEQVREEVSWDTENSHPQHTI 446
+ + I + W VHY G G ++++ + D + + I
Sbjct: 719 LNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQ----EMVI 774
Query: 447 TNLSPYT--NVSVKLILMNPEGRKESQELIVQTDEDLPGAV---PTESIQGSTFEEKIFL 501
TNL P T +++V M +G + +++V GAV PT S+Q T E +
Sbjct: 775 TNLQPETAYSITVAAYTMKGDGARSKPKVVVTK-----GAVLGRPTLSVQ-QTPEGSLLA 828
Query: 502 QWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSF 561
+W P G + Y+ + L+ S E + G++ G TY F
Sbjct: 829 RWEPPA---GTAEDQVLGYRLQFGREDSTPLATLEFPPS----EDRYTASGVHKGATYVF 881
Query: 562 TIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVML---KPAHSRGAPV 618
+ A + G G A + P LE N + TV + PA GA V
Sbjct: 882 RLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIV 941
Query: 619 SVYQIVVEEERPRRTKKTTEI 639
Y + V E + TE+
Sbjct: 942 K-YTVAVREAGALGPARETEL 961
Score = 38.5 bits (88), Expect = 0.048
Identities = 73/305 (23%), Positives = 111/305 (36%), Gaps = 54/305 (17%)
Query: 499 IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTT 558
+ L W P Y T Y+I Y ++ ++D G T L L P T
Sbjct: 1028 VLLSWEFP-DNYNSPTPYKIQYNGLTL---DVD-----------GRTTKKLITHLKPHTF 1072
Query: 559 YSFTI--RASTAKGFGPPAT--NQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614
Y+F + R S+ G T F PS+ P D + V L S
Sbjct: 1073 YNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQSP 1126
Query: 615 GAPVSVYQIVVEEERPRR---------TKKTTEILKCYPVPIHFQNASLLNSQY------ 659
PV Y IV+ R R + + ++ + Q SL +S+
Sbjct: 1127 -VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRP 1185
Query: 660 YFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQV 719
Y AA F F GD K Y G+ N L P Y ++ A + + T
Sbjct: 1186 YIAARFSV----LPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT------F 1235
Query: 720 ATKGAATPKPV--PEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKET 776
A + P + P+P+ D + VI +L V II + + +++ K K KRK++
Sbjct: 1236 AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS 1295
Query: 777 MSSTR 781
T+
Sbjct: 1296 EPRTK 1300
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 498 bits (1283), Expect = e-140
Identities = 276/609 (45%), Positives = 373/609 (61%), Gaps = 16/609 (2%)
Query: 864 DTSSLVQSHTYKKREPADVPYQT-GQL-HPAIRVADLLQHITQMKCAEGYGFKEEYESFF 921
+ + L H E + +QT G L HP I +AD+ +H ++K + +EYES
Sbjct: 895 NNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 954
Query: 922 EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY 981
GQ W+ + + N+ KNRY N+IAYDHSRV LQ IEG SDYIN NY+DGY N Y
Sbjct: 955 PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1014
Query: 982 IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLI 1040
IATQGP+ ET DFWRMVW + +A+I+M+T L E R+KC +YWP+ TE Y I+VTL+
Sbjct: 1015 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1074
Query: 1041 ETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPS 1100
+T LA + +RTF++ K G E RE+RQF FT WPDHGVP + T L F+R+VK+ +PP
Sbjct: 1075 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1134
Query: 1101 AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFI 1160
AGP+VVHCSAG GRTGCFIVID ML+ + E VD+Y V +RS+R MVQTE+QY FI
Sbjct: 1135 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1194
Query: 1161 HDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTL-NMVTPTLRVEDCS 1219
H+A+LEA CG+T VPA + + + +++P + + ++ EF+ L N T R
Sbjct: 1195 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS-- 1252
Query: 1220 IALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLP 1278
A LP N KNR ++I+P + L I G E S+YINA+ +D Y+Q A+I TQ PL
Sbjct: 1253 -ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1311
Query: 1279 NTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDI 1336
T +DFWR++ + + T VVML + + C QYWP R Q V E ++
Sbjct: 1312 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNM 1368
Query: 1337 ISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGE 1395
I R + +DG R V+QFQF WP + P S F+ I QV K +E++ G +
Sbjct: 1369 PQYILREFKVTDARDGQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQD 1426
Query: 1396 GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCY 1455
G VHC G GR+G F +SIV E +R++ VD+F VK LR +P MV D+Y+FCY
Sbjct: 1427 GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1486
Query: 1456 EVALEYLNS 1464
+ ALEYL S
Sbjct: 1487 QAALEYLGS 1495
Score = 133 bits (334), Expect = 1e-30
Identities = 83/243 (34%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284
N KNR +++ D L I+G S+YINA +D Y+ +A+I TQ PLP T DF
Sbjct: 969 NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF 1028
Query: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342
WR+V + ++VM+ ++ C QYWP G +G IQV + R F
Sbjct: 1029 WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFS 1088
Query: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402
++ + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1089 LHKNGSSEK--REVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNPP---DAGPIVVHC 1142
Query: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462
G GR+G F I + E ++ ++TVDV+ V +R+ + MV DQY F +E LE +
Sbjct: 1143 SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1202
Query: 1463 NSG 1465
G
Sbjct: 1203 GCG 1205
Score = 77.0 bits (188), Expect = 1e-13
Identities = 97/400 (24%), Positives = 167/400 (41%), Gaps = 43/400 (10%)
Query: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK-R 253
E+ G C A+G + + W+QG + +T NV+ T +
Sbjct: 242 EIMPGGNVNITCVAVGSPMPYVK-WMQGAE---------DLTPEDDMPVGRNVLELTDVK 291
Query: 254 DAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPI 313
D+ Y C+ + GV I A++ VK P P + AT + I ++ + + P+
Sbjct: 292 DSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPD---PV 347
Query: 314 VAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALR 371
+EY + S G + ++ + +T Y IG L P++EYEI V + G G P ++
Sbjct: 348 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVV 405
Query: 372 TRTKCADPMRGPRKLEVVEVKSRQITIRW-EPFGYN-VTRCHSYNLTVHYCYQVGGQEQV 429
TRT P PR ++ + + + ++W EP N + R + T+ + VG ++
Sbjct: 406 TRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKH 465
Query: 430 REEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTE 488
+ S T T+ +L +V+++ G S + V+T + +PG P
Sbjct: 466 NVDDSLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMN 517
Query: 489 SIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHF 548
+ E I L W P Q I YE+ ++ E D + GR T +
Sbjct: 518 LRAEARSETSITLSWSPPRQE--SIIKYELLFR-------EGDHGREVGRT--FDPTTSY 566
Query: 549 LFFGLYPGTTYSFTIRASTAKGFG--PPATNQFTTKISAP 586
+ L P T Y+F + A + +G G P Q T + +P
Sbjct: 567 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISP 606
Score = 55.5 bits (132), Expect = 4e-07
Identities = 111/482 (23%), Positives = 174/482 (36%), Gaps = 75/482 (15%)
Query: 325 GSWNDRQPVDSTSYKIGHLDPDTEYEISVL-LTRPGEGGTGSPGPALRTRTKCADPMRGP 383
G+W DS +G L D Y + VL T G+G P ++ +T+ P + P
Sbjct: 460 GNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDP---IQVKTQQGVPGQ-P 515
Query: 384 RKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVG--GQEQVREEVSWDTENSH 441
L IT+ W P R S + ++ G G+E R T +
Sbjct: 516 MNLRAEARSETSITLSWSP-----PRQESI-IKYELLFREGDHGREVGR------TFDPT 563
Query: 442 PQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFL 501
+ + +L P T + +L +P+G ++ Q L P + + L
Sbjct: 564 TSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQ--RTLQSISPKNFKVKMIMKTSVLL 621
Query: 502 QWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSF 561
W P Y T Y+I Y ++ ++D G T L L P T Y+F
Sbjct: 622 SWEFP-DNYNSPTPYKIQYNGLTL---DVD-----------GRTTKKLITHLKPHTFYNF 666
Query: 562 TI--RASTAKGFGPPAT--NQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAP 617
+ R S+ G T F PS+ P D + V L S P
Sbjct: 667 VLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQSP-VP 719
Query: 618 VSVYQIVVEEERPRR---------TKKTTEILKCYPVPIHFQNASLLNSQY------YFA 662
V Y IV+ R R + + ++ + Q SL +S+ Y A
Sbjct: 720 VQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIA 779
Query: 663 AEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATK 722
A F F GD K Y G+ N L P Y ++ A + + T A
Sbjct: 780 ARFSV----LPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT------FAAS 829
Query: 723 GAATPKPV--PEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKETMSS 779
+ P + P+P+ D + VI +L V II + + +++ K K KRK++
Sbjct: 830 PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR 889
Query: 780 TR 781
T+
Sbjct: 890 TK 891
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 498 bits (1282), Expect = e-140
Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)
Query: 890 HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 949
HP I + +L HI ++K + F +EYES GQ W+ + + N+ KNRY N+IAYD
Sbjct: 924 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 983
Query: 950 HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 1009
HSRV L IEG SDY+N NYIDGY + N YIATQG + ET DFWRM+W + +A+++M
Sbjct: 984 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1043
Query: 1010 VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1068
+T L E RVKC +YWP TE + ++VTL++T LA Y +RTFA+ K G E RE+RQ
Sbjct: 1044 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1103
Query: 1069 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1128
F FT WPDHGVP H T L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+
Sbjct: 1104 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1163
Query: 1129 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1188
+ E VDIY V +R++R MVQTE+QY+FIHDA+LEA CG+T VPA + + +
Sbjct: 1164 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1223
Query: 1189 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1248
+++ N + ++ EF+ L + A LP N KNR ++I+P + L I
Sbjct: 1224 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1281
Query: 1249 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1305
G E S+YINA+ +D Y+Q A+I TQ PL T +DFWR++ +++ T VVML +
Sbjct: 1282 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1341
Query: 1306 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1364
+ C QYWP R Q V E ++ I R + +DG R V+QFQF W
Sbjct: 1342 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1398
Query: 1365 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1424
P + P S F+ I QV K +E++ G +G VHC G GR+G F +SIV E +R+
Sbjct: 1399 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1456
Query: 1425 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464
+ VD+F VK LR +P MV DQY+F Y ALEYL S
Sbjct: 1457 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1496
Score = 137 bits (344), Expect = 1e-31
Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284
N KNR +++ D L I+G S+Y+NA +D Y++ +A+I TQ LP T DF
Sbjct: 970 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1029
Query: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342
WR++ + +VVM+ ++ C QYWP G HG +QV + R F
Sbjct: 1030 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1089
Query: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402
+Y + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1090 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1143
Query: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462
G GR+G F I + E ++H++TVD++ V +R + MV DQY F ++ LE +
Sbjct: 1144 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1203
Query: 1463 NSG 1465
G
Sbjct: 1204 TCG 1206
Score = 66.6 bits (161), Expect = 2e-10
Identities = 94/440 (21%), Positives = 165/440 (37%), Gaps = 69/440 (15%)
Query: 244 SFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLN 303
+ + + + D GKY C+ G S A L V+E P S+ T I +
Sbjct: 188 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEI-MP 246
Query: 304 ANSINGDGPIVAREVEYCTASGSW---------NDRQPVDSTSYKIGHLDPDTEYEISVL 354
S+N V + Y W D P+ ++ + Y +
Sbjct: 247 GGSVNITCVAVGSPMPYV----KWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAM 302
Query: 355 LTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRW-----EPFGYNVTR 409
T A+ T A P + P V E + IT+ W EP Y + +
Sbjct: 303 STL-------GVIEAIAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ 354
Query: 410 CHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-K 468
N E++ +E+ ++++ LSPY++ +++ +N GR
Sbjct: 355 HKPKN-----------SEELYKEIDGVATT---RYSVAGLSPYSDYEFRVVAVNNIGRGP 400
Query: 469 ESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDP 528
S+ ++ QT E P + P + I +QW+EP + G I Y + Y + DP
Sbjct: 401 PSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDP 456
Query: 529 EIDLSN------QSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581
++N +++ +GN L P TYS + A T+ G GP +++ Q T
Sbjct: 457 TQHVNNWMKHNVADSQITTIGN--------LVPQKTYSVKVLAFTSIGDGPLSSDIQVIT 508
Query: 582 KISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILK 641
+ P P P ++T +++L R ++ Y++V ++ ++ T
Sbjct: 509 QTGVPGQPLNFKAEPESET----SILLSWTPPRSDTIANYELVYKDGEHGEEQRIT---- 560
Query: 642 CYPVPIHFQNASLLNSQYYF 661
P + NS YYF
Sbjct: 561 IEPGTSYRLQGLKPNSLYYF 580
Score = 63.9 bits (154), Expect = 1e-09
Identities = 95/401 (23%), Positives = 155/401 (38%), Gaps = 44/401 (10%)
Query: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
N E+ G C A+G + + L D+ P ++ + R + N V
Sbjct: 241 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 291
Query: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
R + Y C+ + GV I A++ VK P P P + AT I L +S N + P
Sbjct: 292 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 347
Query: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370
+ +++ + + + V +T Y + L P ++YE V+ G G P +
Sbjct: 348 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 405
Query: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430
T+T P PR ++ + S I ++W+ + Y + Y + + V
Sbjct: 406 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 461
Query: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489
+ + +S TI NL P SVK++ G S ++ V T +PG P
Sbjct: 462 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 519
Query: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547
E I L W P I YE+ YK + G ++ E T
Sbjct: 520 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 566
Query: 548 FLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSM 588
+ GL P + Y F + A + +G G T +ISA +M
Sbjct: 567 YRLQGLKPNSLYYFRLAARSPQGLGAS-----TAEISARTM 602
Score = 51.2 bits (121), Expect = 7e-06
Identities = 105/481 (21%), Positives = 175/481 (36%), Gaps = 81/481 (16%)
Query: 326 SWNDRQPVDSTSYKIGHLDPDTEYEISVL-LTRPGEGGTGSPGPALRTRTKCADPMRGPR 384
+W DS IG+L P Y + VL T G+G S ++ T+ P + P
Sbjct: 462 NWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSD---IQVITQTGVPGQ-PL 517
Query: 385 KLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQH 444
+ I + W P S + + G+ + ++ + S+
Sbjct: 518 NFKAEPESETSILLSWTP-------PRSDTIANYELVYKDGEHGEEQRITIEPGTSY--- 567
Query: 445 TITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEK------ 498
+ L P + +L +P+G S I A +S+ F K
Sbjct: 568 RLQGLKPNSLYYFRLAARSPQGLGASTAEI--------SARTMQSMFAKNFHVKAVMKTS 619
Query: 499 IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTT 558
+ L W P + Y ++I Y + E+D G T L L P +
Sbjct: 620 VLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEKS 666
Query: 559 YSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHSR 614
YSF + T +G T +AP + PA+ +T L D +TV L P
Sbjct: 667 YSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVPA 719
Query: 615 GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS----------------Q 658
+ Y I++ + R K +K + P + LL +
Sbjct: 720 NENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVELK 775
Query: 659 YYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQ 718
Y AA F + FT+GD+K Y G+ N L + Y ++F A + E+K+
Sbjct: 776 PYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATS 830
Query: 719 VATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKETM 777
+ + P+P TD + V+ +L V II + + +++ K K +KR E+
Sbjct: 831 PYSDPVVSMDLDPQP--ITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESD 888
Query: 778 S 778
S
Sbjct: 889 S 889
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 498 bits (1282), Expect = e-140
Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)
Query: 890 HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 949
HP I + +L HI ++K + F +EYES GQ W+ + + N+ KNRY N+IAYD
Sbjct: 1334 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1393
Query: 950 HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 1009
HSRV L IEG SDY+N NYIDGY + N YIATQG + ET DFWRM+W + +A+++M
Sbjct: 1394 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1453
Query: 1010 VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1068
+T L E RVKC +YWP TE + ++VTL++T LA Y +RTFA+ K G E RE+RQ
Sbjct: 1454 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1513
Query: 1069 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1128
F FT WPDHGVP H T L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+
Sbjct: 1514 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1573
Query: 1129 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1188
+ E VDIY V +R++R MVQTE+QY+FIHDA+LEA CG+T VPA + + +
Sbjct: 1574 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1633
Query: 1189 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1248
+++ N + ++ EF+ L + A LP N KNR ++I+P + L I
Sbjct: 1634 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1691
Query: 1249 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1305
G E S+YINA+ +D Y+Q A+I TQ PL T +DFWR++ +++ T VVML +
Sbjct: 1692 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1751
Query: 1306 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1364
+ C QYWP R Q V E ++ I R + +DG R V+QFQF W
Sbjct: 1752 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1808
Query: 1365 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1424
P + P S F+ I QV K +E++ G +G VHC G GR+G F +SIV E +R+
Sbjct: 1809 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1866
Query: 1425 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464
+ VD+F VK LR +P MV DQY+F Y ALEYL S
Sbjct: 1867 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1906
Score = 137 bits (344), Expect = 1e-31
Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284
N KNR +++ D L I+G S+Y+NA +D Y++ +A+I TQ LP T DF
Sbjct: 1380 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1439
Query: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342
WR++ + +VVM+ ++ C QYWP G HG +QV + R F
Sbjct: 1440 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1499
Query: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402
+Y + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1500 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1553
Query: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462
G GR+G F I + E ++H++TVD++ V +R + MV DQY F ++ LE +
Sbjct: 1554 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1613
Query: 1463 NSG 1465
G
Sbjct: 1614 TCG 1616
Score = 69.3 bits (168), Expect = 3e-11
Identities = 77/349 (22%), Positives = 127/349 (36%), Gaps = 31/349 (8%)
Query: 258 YRCMIRTEGGVGISNYAELVVKEPPVPIAPPQ---LASVGATYLWIQLNANSINGDGPIV 314
+R R+ G+G S P APPQ S +T + + + I+
Sbjct: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
Query: 315 AREVEYCTASGSWNDRQ------PVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGP 368
TA +D+ P D+T Y + L+ TEY I+V T + G G
Sbjct: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPESL 700
Query: 369 ALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQ 428
++ RT P PRK+EV V S + + W N VHY G+ +
Sbjct: 701 SVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPK 760
Query: 429 --------VREEVSWDTENSHPQHTI-TNLSPYTNVSVKLILMNPEGR-KESQELIVQTD 478
+ + W+ +++ I + L P T+ S+ + +G S+ +V T
Sbjct: 761 GQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 820
Query: 479 EDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGR 538
+PG + T +QW P T+G + Y + + +P L
Sbjct: 821 GAVPGK--PRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGR-KDMEPLTTLEFSE-- 875
Query: 539 VSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPS 587
E HF ++ G +Y F + A GFG + + P+
Sbjct: 876 -----KEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 919
Score = 67.4 bits (163), Expect = 1e-10
Identities = 102/438 (23%), Positives = 167/438 (38%), Gaps = 41/438 (9%)
Query: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
N E+ G C A+G + + L D+ P ++ + R + N V
Sbjct: 244 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 294
Query: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
R + Y C+ + GV I A++ VK P P P + AT I L +S N + P
Sbjct: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 350
Query: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370
+ +++ + + + V +T Y + L P ++YE V+ G G P +
Sbjct: 351 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 408
Query: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430
T+T P PR ++ + S I ++W+ + Y + Y + + V
Sbjct: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 464
Query: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489
+ + +S TI NL P SVK++ G S ++ V T +PG P
Sbjct: 465 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 522
Query: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547
E I L W P I YE+ YK + G ++ E T
Sbjct: 523 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 569
Query: 548 FLFFGLYPGTTYSFTIRASTAKGFG-PPATNQFTTKISAPSMPAYELE-TPLNQTDNTVT 605
+ GL P + Y F + A + +G G A T S PS P ++ T + T V+
Sbjct: 570 YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 629
Query: 606 VMLKPAHSRGAPVSVYQI 623
P + ++ Y I
Sbjct: 630 WQPPPVEKQNGIITEYSI 647
Score = 66.6 bits (161), Expect = 2e-10
Identities = 94/440 (21%), Positives = 165/440 (37%), Gaps = 69/440 (15%)
Query: 244 SFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLN 303
+ + + + D GKY C+ G S A L V+E P S+ T I +
Sbjct: 191 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEI-MP 249
Query: 304 ANSINGDGPIVAREVEYCTASGSW---------NDRQPVDSTSYKIGHLDPDTEYEISVL 354
S+N V + Y W D P+ ++ + Y +
Sbjct: 250 GGSVNITCVAVGSPMPYV----KWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAM 305
Query: 355 LTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRW-----EPFGYNVTR 409
T A+ T A P + P V E + IT+ W EP Y + +
Sbjct: 306 STL-------GVIEAIAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ 357
Query: 410 CHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-K 468
N E++ +E+ ++++ LSPY++ +++ +N GR
Sbjct: 358 HKPKN-----------SEELYKEIDGVATT---RYSVAGLSPYSDYEFRVVAVNNIGRGP 403
Query: 469 ESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDP 528
S+ ++ QT E P + P + I +QW+EP + G I Y + Y + DP
Sbjct: 404 PSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDP 459
Query: 529 EIDLSN------QSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581
++N +++ +GN L P TYS + A T+ G GP +++ Q T
Sbjct: 460 TQHVNNWMKHNVADSQITTIGN--------LVPQKTYSVKVLAFTSIGDGPLSSDIQVIT 511
Query: 582 KISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILK 641
+ P P P ++T +++L R ++ Y++V ++ ++ T
Sbjct: 512 QTGVPGQPLNFKAEPESET----SILLSWTPPRSDTIANYELVYKDGEHGEEQRIT---- 563
Query: 642 CYPVPIHFQNASLLNSQYYF 661
P + NS YYF
Sbjct: 564 IEPGTSYRLQGLKPNSLYYF 583
Score = 58.5 bits (140), Expect = 4e-08
Identities = 78/351 (22%), Positives = 129/351 (36%), Gaps = 45/351 (12%)
Query: 257 KYRCMI--RTEGGVGISNYAELVVKEPPVPIAPP---QLASVGATYLWIQLNANSINGD- 310
+YR + T+ G G + + L+ VP PP ++ +V +T + + + N
Sbjct: 682 EYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQH 741
Query: 311 GPIVAREVEYCTASGSWNDRQPV--------------DSTSYK--IGHLDPDTEYEISVL 354
G I +V Y QP+ D+T + I L P+T Y ++V
Sbjct: 742 GQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVT 801
Query: 355 L-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSY 413
T G+G P T + G +L + + I+W P Y
Sbjct: 802 AYTTKGDGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGY 856
Query: 414 NLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQEL 473
L G++ + + + T T++ + +L N G E
Sbjct: 857 RLKF-------GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVK 909
Query: 474 IVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEID 531
+ E++P P T + L W+ P + G+IT Y + Y+ D I
Sbjct: 910 EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-----DINIP 964
Query: 532 LSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581
L + + +T GL P TTY +RA T+KG GP + + QF T
Sbjct: 965 LLPMEQLI--VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1013
Score = 51.6 bits (122), Expect = 5e-06
Identities = 78/366 (21%), Positives = 139/366 (37%), Gaps = 64/366 (17%)
Query: 445 TITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTESIQGSTFEEK----- 498
T+T L P T VK+ +G S + +T +P + + F K
Sbjct: 980 TLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVMKT 1032
Query: 499 -IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGT 557
+ L W P + Y ++I Y + E+D G T L L P
Sbjct: 1033 SVLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEK 1079
Query: 558 TYSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHS 613
+YSF + T +G T +AP + PA+ +T L D +TV L P
Sbjct: 1080 SYSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVP 1132
Query: 614 RGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS---------------- 657
+ Y I++ + R K +K + P + LL
Sbjct: 1133 ANENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVEL 1188
Query: 658 QYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCV 717
+ Y AA F + FT+GD+K Y G+ N L + Y ++F A + E+K+
Sbjct: 1189 KPYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYAT 1243
Query: 718 QVATKGAATPKPVPEP-EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKET 776
+ + P+P + + + + G + ++ + I + ++L +KR + RK +
Sbjct: 1244 SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSS 1303
Query: 777 MSSTRQ 782
+ + ++
Sbjct: 1304 IPNNKE 1309
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 498 bits (1282), Expect = e-140
Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)
Query: 890 HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 949
HP I + +L HI ++K + F +EYES GQ W+ + + N+ KNRY N+IAYD
Sbjct: 1321 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1380
Query: 950 HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 1009
HSRV L IEG SDY+N NYIDGY + N YIATQG + ET DFWRM+W + +A+++M
Sbjct: 1381 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1440
Query: 1010 VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1068
+T L E RVKC +YWP TE + ++VTL++T LA Y +RTFA+ K G E RE+RQ
Sbjct: 1441 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1500
Query: 1069 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1128
F FT WPDHGVP H T L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+
Sbjct: 1501 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1560
Query: 1129 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1188
+ E VDIY V +R++R MVQTE+QY+FIHDA+LEA CG+T VPA + + +
Sbjct: 1561 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1620
Query: 1189 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1248
+++ N + ++ EF+ L + A LP N KNR ++I+P + L I
Sbjct: 1621 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1678
Query: 1249 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1305
G E S+YINA+ +D Y+Q A+I TQ PL T +DFWR++ +++ T VVML +
Sbjct: 1679 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1738
Query: 1306 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1364
+ C QYWP R Q V E ++ I R + +DG R V+QFQF W
Sbjct: 1739 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1795
Query: 1365 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1424
P + P S F+ I QV K +E++ G +G VHC G GR+G F +SIV E +R+
Sbjct: 1796 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1853
Query: 1425 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464
+ VD+F VK LR +P MV DQY+F Y ALEYL S
Sbjct: 1854 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1893
Score = 137 bits (344), Expect = 1e-31
Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284
N KNR +++ D L I+G S+Y+NA +D Y++ +A+I TQ LP T DF
Sbjct: 1367 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1426
Query: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342
WR++ + +VVM+ ++ C QYWP G HG +QV + R F
Sbjct: 1427 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1486
Query: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402
+Y + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1487 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1540
Query: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462
G GR+G F I + E ++H++TVD++ V +R + MV DQY F ++ LE +
Sbjct: 1541 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1600
Query: 1463 NSG 1465
G
Sbjct: 1601 TCG 1603
Score = 69.3 bits (168), Expect = 3e-11
Identities = 77/349 (22%), Positives = 127/349 (36%), Gaps = 31/349 (8%)
Query: 258 YRCMIRTEGGVGISNYAELVVKEPPVPIAPPQ---LASVGATYLWIQLNANSINGDGPIV 314
+R R+ G+G S P APPQ S +T + + + I+
Sbjct: 570 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 629
Query: 315 AREVEYCTASGSWNDRQ------PVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGP 368
TA +D+ P D+T Y + L+ TEY I+V T + G G
Sbjct: 630 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPESL 687
Query: 369 ALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQ 428
++ RT P PRK+EV V S + + W N VHY G+ +
Sbjct: 688 SVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPK 747
Query: 429 --------VREEVSWDTENSHPQHTI-TNLSPYTNVSVKLILMNPEGR-KESQELIVQTD 478
+ + W+ +++ I + L P T+ S+ + +G S+ +V T
Sbjct: 748 GQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 807
Query: 479 EDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGR 538
+PG + T +QW P T+G + Y + + +P L
Sbjct: 808 GAVPGK--PRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGR-KDMEPLTTLEFSE-- 862
Query: 539 VSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPS 587
E HF ++ G +Y F + A GFG + + P+
Sbjct: 863 -----KEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 906
Score = 67.4 bits (163), Expect = 1e-10
Identities = 102/438 (23%), Positives = 167/438 (38%), Gaps = 41/438 (9%)
Query: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
N E+ G C A+G + + L D+ P ++ + R + N V
Sbjct: 231 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 281
Query: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
R + Y C+ + GV I A++ VK P P P + AT I L +S N + P
Sbjct: 282 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 337
Query: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370
+ +++ + + + V +T Y + L P ++YE V+ G G P +
Sbjct: 338 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 395
Query: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430
T+T P PR ++ + S I ++W+ + Y + Y + + V
Sbjct: 396 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 451
Query: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489
+ + +S TI NL P SVK++ G S ++ V T +PG P
Sbjct: 452 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 509
Query: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547
E I L W P I YE+ YK + G ++ E T
Sbjct: 510 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 556
Query: 548 FLFFGLYPGTTYSFTIRASTAKGFG-PPATNQFTTKISAPSMPAYELE-TPLNQTDNTVT 605
+ GL P + Y F + A + +G G A T S PS P ++ T + T V+
Sbjct: 557 YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 616
Query: 606 VMLKPAHSRGAPVSVYQI 623
P + ++ Y I
Sbjct: 617 WQPPPVEKQNGIITEYSI 634
Score = 65.1 bits (157), Expect = 5e-10
Identities = 65/287 (22%), Positives = 119/287 (41%), Gaps = 47/287 (16%)
Query: 388 VVEVKSRQITIRW-----EPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHP 442
V E + IT+ W EP Y + + N E++ +E+
Sbjct: 318 VTESTATSITLTWDSGNPEPVSYYIIQHKPKN-----------SEELYKEIDGVATT--- 363
Query: 443 QHTITNLSPYTNVSVKLILMNPEGR-KESQELIVQTDEDLPGAVPTESIQGSTFEEKIFL 501
++++ LSPY++ +++ +N GR S+ ++ QT E P + P + I +
Sbjct: 364 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 423
Query: 502 QWREPTQTYGVITLYEITYKAVSSFDPEIDLSN------QSGRVSKLGNETHFLFFGLYP 555
QW+EP + G I Y + Y + DP ++N +++ +GN L P
Sbjct: 424 QWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMKHNVADSQITTIGN--------LVP 471
Query: 556 GTTYSFTIRASTAKGFGPPATN-QFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614
TYS + A T+ G GP +++ Q T+ P P P ++T +++L R
Sbjct: 472 QKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESET----SILLSWTPPR 527
Query: 615 GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYF 661
++ Y++V ++ ++ T P + NS YYF
Sbjct: 528 SDTIANYELVYKDGEHGEEQRIT----IEPGTSYRLQGLKPNSLYYF 570
Score = 58.5 bits (140), Expect = 4e-08
Identities = 78/351 (22%), Positives = 129/351 (36%), Gaps = 45/351 (12%)
Query: 257 KYRCMI--RTEGGVGISNYAELVVKEPPVPIAPP---QLASVGATYLWIQLNANSINGD- 310
+YR + T+ G G + + L+ VP PP ++ +V +T + + + N
Sbjct: 669 EYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQH 728
Query: 311 GPIVAREVEYCTASGSWNDRQPV--------------DSTSYK--IGHLDPDTEYEISVL 354
G I +V Y QP+ D+T + I L P+T Y ++V
Sbjct: 729 GQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVT 788
Query: 355 L-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSY 413
T G+G P T + G +L + + I+W P Y
Sbjct: 789 AYTTKGDGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGY 843
Query: 414 NLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQEL 473
L G++ + + + T T++ + +L N G E
Sbjct: 844 RLKF-------GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVK 896
Query: 474 IVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEID 531
+ E++P P T + L W+ P + G+IT Y + Y+ D I
Sbjct: 897 EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-----DINIP 951
Query: 532 LSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581
L + + +T GL P TTY +RA T+KG GP + + QF T
Sbjct: 952 LLPMEQLI--VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1000
Score = 51.6 bits (122), Expect = 5e-06
Identities = 78/366 (21%), Positives = 139/366 (37%), Gaps = 64/366 (17%)
Query: 445 TITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTESIQGSTFEEK----- 498
T+T L P T VK+ +G S + +T +P + + F K
Sbjct: 967 TLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVMKT 1019
Query: 499 -IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGT 557
+ L W P + Y ++I Y + E+D G T L L P
Sbjct: 1020 SVLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEK 1066
Query: 558 TYSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHS 613
+YSF + T +G T +AP + PA+ +T L D +TV L P
Sbjct: 1067 SYSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVP 1119
Query: 614 RGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS---------------- 657
+ Y I++ + R K +K + P + LL
Sbjct: 1120 ANENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVEL 1175
Query: 658 QYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCV 717
+ Y AA F + FT+GD+K Y G+ N L + Y ++F A + E+K+
Sbjct: 1176 KPYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYAT 1230
Query: 718 QVATKGAATPKPVPEP-EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKET 776
+ + P+P + + + + G + ++ + I + ++L +KR + RK +
Sbjct: 1231 SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSS 1290
Query: 777 MSSTRQ 782
+ + ++
Sbjct: 1291 IPNNKE 1296
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 498 bits (1282), Expect = e-140
Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)
Query: 890 HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 949
HP I + +L HI ++K + F +EYES GQ W+ + + N+ KNRY N+IAYD
Sbjct: 1325 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1384
Query: 950 HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 1009
HSRV L IEG SDY+N NYIDGY + N YIATQG + ET DFWRM+W + +A+++M
Sbjct: 1385 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1444
Query: 1010 VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1068
+T L E RVKC +YWP TE + ++VTL++T LA Y +RTFA+ K G E RE+RQ
Sbjct: 1445 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1504
Query: 1069 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1128
F FT WPDHGVP H T L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+
Sbjct: 1505 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1564
Query: 1129 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1188
+ E VDIY V +R++R MVQTE+QY+FIHDA+LEA CG+T VPA + + +
Sbjct: 1565 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1624
Query: 1189 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1248
+++ N + ++ EF+ L + A LP N KNR ++I+P + L I
Sbjct: 1625 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1682
Query: 1249 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1305
G E S+YINA+ +D Y+Q A+I TQ PL T +DFWR++ +++ T VVML +
Sbjct: 1683 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1742
Query: 1306 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1364
+ C QYWP R Q V E ++ I R + +DG R V+QFQF W
Sbjct: 1743 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1799
Query: 1365 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1424
P + P S F+ I QV K +E++ G +G VHC G GR+G F +SIV E +R+
Sbjct: 1800 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1857
Query: 1425 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464
+ VD+F VK LR +P MV DQY+F Y ALEYL S
Sbjct: 1858 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1897
Score = 137 bits (344), Expect = 1e-31
Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284
N KNR +++ D L I+G S+Y+NA +D Y++ +A+I TQ LP T DF
Sbjct: 1371 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1430
Query: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342
WR++ + +VVM+ ++ C QYWP G HG +QV + R F
Sbjct: 1431 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1490
Query: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402
+Y + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1491 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1544
Query: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462
G GR+G F I + E ++H++TVD++ V +R + MV DQY F ++ LE +
Sbjct: 1545 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1604
Query: 1463 NSG 1465
G
Sbjct: 1605 TCG 1607
Score = 68.9 bits (167), Expect = 3e-11
Identities = 78/344 (22%), Positives = 126/344 (36%), Gaps = 30/344 (8%)
Query: 258 YRCMIRTEGGVGISNYAELVVKEPPVPIAPPQ---LASVGATYLWIQLNANSINGDGPIV 314
+R R+ G+G S P APPQ S +T + + + I+
Sbjct: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
Query: 315 AREVEYCTASGSWNDRQ------PVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGP 368
TA +D+ P D+T Y + L+ TEY I+V T + G G
Sbjct: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPESL 700
Query: 369 ALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGG--- 425
++ RT P PRK+EV V S + + W N VHY G
Sbjct: 701 SVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPK 760
Query: 426 -QEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-KESQELIVQTDEDLPG 483
Q +++ + D ++ I+ L P T+ S+ + +G S+ +V T +PG
Sbjct: 761 GQPMLKDVMLADAQDM----IISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 816
Query: 484 AVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLG 543
+ T +QW P T+G + Y + + +P L
Sbjct: 817 K--PRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGR-KDMEPLTTLEFSE------- 866
Query: 544 NETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPS 587
E HF ++ G +Y F + A GFG + + P+
Sbjct: 867 KEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 910
Score = 67.4 bits (163), Expect = 1e-10
Identities = 102/438 (23%), Positives = 167/438 (38%), Gaps = 41/438 (9%)
Query: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
N E+ G C A+G + + L D+ P ++ + R + N V
Sbjct: 244 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 294
Query: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
R + Y C+ + GV I A++ VK P P P + AT I L +S N + P
Sbjct: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 350
Query: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370
+ +++ + + + V +T Y + L P ++YE V+ G G P +
Sbjct: 351 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 408
Query: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430
T+T P PR ++ + S I ++W+ + Y + Y + + V
Sbjct: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 464
Query: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489
+ + +S TI NL P SVK++ G S ++ V T +PG P
Sbjct: 465 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 522
Query: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547
E I L W P I YE+ YK + G ++ E T
Sbjct: 523 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 569
Query: 548 FLFFGLYPGTTYSFTIRASTAKGFG-PPATNQFTTKISAPSMPAYELE-TPLNQTDNTVT 605
+ GL P + Y F + A + +G G A T S PS P ++ T + T V+
Sbjct: 570 YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 629
Query: 606 VMLKPAHSRGAPVSVYQI 623
P + ++ Y I
Sbjct: 630 WQPPPVEKQNGIITEYSI 647
Score = 66.6 bits (161), Expect = 2e-10
Identities = 94/440 (21%), Positives = 165/440 (37%), Gaps = 69/440 (15%)
Query: 244 SFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLN 303
+ + + + D GKY C+ G S A L V+E P S+ T I +
Sbjct: 191 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEI-MP 249
Query: 304 ANSINGDGPIVAREVEYCTASGSW---------NDRQPVDSTSYKIGHLDPDTEYEISVL 354
S+N V + Y W D P+ ++ + Y +
Sbjct: 250 GGSVNITCVAVGSPMPYV----KWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAM 305
Query: 355 LTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRW-----EPFGYNVTR 409
T A+ T A P + P V E + IT+ W EP Y + +
Sbjct: 306 STL-------GVIEAIAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ 357
Query: 410 CHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-K 468
N E++ +E+ ++++ LSPY++ +++ +N GR
Sbjct: 358 HKPKN-----------SEELYKEIDGVATT---RYSVAGLSPYSDYEFRVVAVNNIGRGP 403
Query: 469 ESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDP 528
S+ ++ QT E P + P + I +QW+EP + G I Y + Y + DP
Sbjct: 404 PSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDP 459
Query: 529 EIDLSN------QSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581
++N +++ +GN L P TYS + A T+ G GP +++ Q T
Sbjct: 460 TQHVNNWMKHNVADSQITTIGN--------LVPQKTYSVKVLAFTSIGDGPLSSDIQVIT 511
Query: 582 KISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILK 641
+ P P P ++T +++L R ++ Y++V ++ ++ T
Sbjct: 512 QTGVPGQPLNFKAEPESET----SILLSWTPPRSDTIANYELVYKDGEHGEEQRIT---- 563
Query: 642 CYPVPIHFQNASLLNSQYYF 661
P + NS YYF
Sbjct: 564 IEPGTSYRLQGLKPNSLYYF 583
Score = 62.0 bits (149), Expect = 4e-09
Identities = 77/342 (22%), Positives = 127/342 (37%), Gaps = 36/342 (10%)
Query: 257 KYRCMI--RTEGGVGISNYAELVVKEPPVPIAPP---QLASVGATYLWIQLNANSINGD- 310
+YR + T+ G G + + L+ VP PP ++ +V +T + + + N
Sbjct: 682 EYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQH 741
Query: 311 GPIVAREVEYCTASGSWNDRQPV-------DSTSYKIGHLDPDTEYEISVLL-TRPGEGG 362
G I +V Y QP+ D+ I L P+T Y ++V T G+G
Sbjct: 742 GQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGA 801
Query: 363 TGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQ 422
P T + G +L + + I+W P Y L
Sbjct: 802 RSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKF----- 851
Query: 423 VGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLP 482
G++ + + + T T++ + +L N G E + E++P
Sbjct: 852 --GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVP 909
Query: 483 GAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS 540
P T + L W+ P + G+IT Y + Y+ D I L +
Sbjct: 910 TGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-----DINIPLLPMEQLI- 963
Query: 541 KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581
+ +T GL P TTY +RA T+KG GP + + QF T
Sbjct: 964 -VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1004
Score = 51.6 bits (122), Expect = 5e-06
Identities = 78/366 (21%), Positives = 139/366 (37%), Gaps = 64/366 (17%)
Query: 445 TITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTESIQGSTFEEK----- 498
T+T L P T VK+ +G S + +T +P + + F K
Sbjct: 971 TLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVMKT 1023
Query: 499 -IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGT 557
+ L W P + Y ++I Y + E+D G T L L P
Sbjct: 1024 SVLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEK 1070
Query: 558 TYSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHS 613
+YSF + T +G T +AP + PA+ +T L D +TV L P
Sbjct: 1071 SYSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVP 1123
Query: 614 RGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS---------------- 657
+ Y I++ + R K +K + P + LL
Sbjct: 1124 ANENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVEL 1179
Query: 658 QYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCV 717
+ Y AA F + FT+GD+K Y G+ N L + Y ++F A + E+K+
Sbjct: 1180 KPYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYAT 1234
Query: 718 QVATKGAATPKPVPEP-EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKET 776
+ + P+P + + + + G + ++ + I + ++L +KR + RK +
Sbjct: 1235 SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSS 1294
Query: 777 MSSTRQ 782
+ + ++
Sbjct: 1295 IPNNKE 1300
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 498 bits (1282), Expect = e-140
Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)
Query: 890 HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 949
HP I + +L HI ++K + F +EYES GQ W+ + + N+ KNRY N+IAYD
Sbjct: 923 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 982
Query: 950 HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 1009
HSRV L IEG SDY+N NYIDGY + N YIATQG + ET DFWRM+W + +A+++M
Sbjct: 983 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1042
Query: 1010 VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1068
+T L E RVKC +YWP TE + ++VTL++T LA Y +RTFA+ K G E RE+RQ
Sbjct: 1043 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1102
Query: 1069 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1128
F FT WPDHGVP H T L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+
Sbjct: 1103 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1162
Query: 1129 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1188
+ E VDIY V +R++R MVQTE+QY+FIHDA+LEA CG+T VPA + + +
Sbjct: 1163 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1222
Query: 1189 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1248
+++ N + ++ EF+ L + A LP N KNR ++I+P + L I
Sbjct: 1223 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1280
Query: 1249 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1305
G E S+YINA+ +D Y+Q A+I TQ PL T +DFWR++ +++ T VVML +
Sbjct: 1281 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1340
Query: 1306 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1364
+ C QYWP R Q V E ++ I R + +DG R V+QFQF W
Sbjct: 1341 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1397
Query: 1365 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1424
P + P S F+ I QV K +E++ G +G VHC G GR+G F +SIV E +R+
Sbjct: 1398 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1455
Query: 1425 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464
+ VD+F VK LR +P MV DQY+F Y ALEYL S
Sbjct: 1456 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1495
Score = 137 bits (344), Expect = 1e-31
Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284
N KNR +++ D L I+G S+Y+NA +D Y++ +A+I TQ LP T DF
Sbjct: 969 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1028
Query: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342
WR++ + +VVM+ ++ C QYWP G HG +QV + R F
Sbjct: 1029 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1088
Query: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402
+Y + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1089 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1142
Query: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462
G GR+G F I + E ++H++TVD++ V +R + MV DQY F ++ LE +
Sbjct: 1143 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1202
Query: 1463 NSG 1465
G
Sbjct: 1203 TCG 1205
Score = 66.6 bits (161), Expect = 2e-10
Identities = 94/440 (21%), Positives = 165/440 (37%), Gaps = 69/440 (15%)
Query: 244 SFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLN 303
+ + + + D GKY C+ G S A L V+E P S+ T I +
Sbjct: 191 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEI-MP 249
Query: 304 ANSINGDGPIVAREVEYCTASGSW---------NDRQPVDSTSYKIGHLDPDTEYEISVL 354
S+N V + Y W D P+ ++ + Y +
Sbjct: 250 GGSVNITCVAVGSPMPYV----KWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAM 305
Query: 355 LTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRW-----EPFGYNVTR 409
T A+ T A P + P V E + IT+ W EP Y + +
Sbjct: 306 STL-------GVIEAIAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ 357
Query: 410 CHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-K 468
N E++ +E+ ++++ LSPY++ +++ +N GR
Sbjct: 358 HKPKN-----------SEELYKEIDGVATT---RYSVAGLSPYSDYEFRVVAVNNIGRGP 403
Query: 469 ESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDP 528
S+ ++ QT E P + P + I +QW+EP + G I Y + Y + DP
Sbjct: 404 PSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDP 459
Query: 529 EIDLSN------QSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581
++N +++ +GN L P TYS + A T+ G GP +++ Q T
Sbjct: 460 TQHVNNWMKHNVADSQITTIGN--------LVPQKTYSVKVLAFTSIGDGPLSSDIQVIT 511
Query: 582 KISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILK 641
+ P P P ++T +++L R ++ Y++V ++ ++ T
Sbjct: 512 QTGVPGQPLNFKAEPESET----SILLSWTPPRSDTIANYELVYKDGEHGEEQRIT---- 563
Query: 642 CYPVPIHFQNASLLNSQYYF 661
P + NS YYF
Sbjct: 564 IEPGTSYRLQGLKPNSLYYF 583
Score = 63.9 bits (154), Expect = 1e-09
Identities = 95/401 (23%), Positives = 155/401 (38%), Gaps = 44/401 (10%)
Query: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
N E+ G C A+G + + L D+ P ++ + R + N V
Sbjct: 244 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 294
Query: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
R + Y C+ + GV I A++ VK P P P + AT I L +S N + P
Sbjct: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 350
Query: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370
+ +++ + + + V +T Y + L P ++YE V+ G G P +
Sbjct: 351 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 408
Query: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430
T+T P PR ++ + S I ++W+ + Y + Y + + V
Sbjct: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 464
Query: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489
+ + +S TI NL P SVK++ G S ++ V T +PG P
Sbjct: 465 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 522
Query: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547
E I L W P I YE+ YK + G ++ E T
Sbjct: 523 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 569
Query: 548 FLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSM 588
+ GL P + Y F + A + +G G T +ISA +M
Sbjct: 570 YRLQGLKPNSLYYFRLAARSPQGLGAS-----TAEISARTM 605
Score = 55.8 bits (133), Expect = 3e-07
Identities = 99/485 (20%), Positives = 177/485 (36%), Gaps = 79/485 (16%)
Query: 326 SWNDRQPVDSTSYKIGHLDPDTEYEISVL-LTRPGEGGTGSPGPALRTRTKCADPMRGPR 384
+W DS IG+L P Y + VL T G+G S ++ T+ P + P
Sbjct: 465 NWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSD---IQVITQTGVPGQ-PL 520
Query: 385 KLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQH 444
+ I + W P S + + G+ + ++ + S+
Sbjct: 521 NFKAEPESETSILLSWTP-------PRSDTIANYELVYKDGEHGEEQRITIEPGTSY--- 570
Query: 445 TITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEK------ 498
+ L P + +L +P+G S I A +S+ F K
Sbjct: 571 RLQGLKPNSLYYFRLAARSPQGLGASTAEI--------SARTMQSMFAKNFHVKAVMKTS 622
Query: 499 IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTT 558
+ L W P + Y ++I Y + E+D G T L L P +
Sbjct: 623 VLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEKS 669
Query: 559 YSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHSR 614
YSF + T +G T +AP + PA+ +T L D +TV L P
Sbjct: 670 YSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVPA 722
Query: 615 GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS----------------Q 658
+ Y I++ + R K +K + P + LL +
Sbjct: 723 NENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVELK 778
Query: 659 YYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQ 718
Y AA F + FT+GD+K Y G+ N L + Y ++F A + E+K+
Sbjct: 779 PYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATS 833
Query: 719 VATKGAATPKPVPEP-EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETM 777
+ + P+P + + + + G + ++ + I + ++L +KR + RK ++
Sbjct: 834 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSI 893
Query: 778 SSTRQ 782
+ ++
Sbjct: 894 PNNKE 898
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 498 bits (1281), Expect = e-140
Identities = 279/629 (44%), Positives = 382/629 (60%), Gaps = 20/629 (3%)
Query: 849 AILVPINDETHTMAS-DTSSL-----VQSHTYKKREPADVPYQTGQL--HPAIRVADLLQ 900
AIL+ TH+ +S D S+ + +H+ E + YQT + HP I + DL
Sbjct: 1280 AILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLAD 1339
Query: 901 HITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEG 960
+I ++K +G F +EYES GQ W+++ + N+ KNRY N+IAYDHSRV L +I+G
Sbjct: 1340 NIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDG 1399
Query: 961 DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVK 1020
SDYIN NYIDGY + N YIATQGP+ ET+ DFWRMVW + TA+++M+T L E RVK
Sbjct: 1400 VPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVK 1459
Query: 1021 CCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGV 1079
C +YWP TE I+VTL++T LA Y +RTFA+ K G E RE+RQF F WPDHGV
Sbjct: 1460 CDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGV 1519
Query: 1080 PYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNC 1139
P + T +L F+R+VK+ +P AGP+VVHCSAG GRTGCFIVID ML+ + E VDIY
Sbjct: 1520 PEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGH 1579
Query: 1140 VRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQI 1199
V +RS+R MVQTE+QYVFIH+A+LEA CG T VPA + + + ++ P + + +
Sbjct: 1580 VTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAM 1639
Query: 1200 KEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINA 1258
+ EF+ L + A LP N KNR ++I+P + L I G E S+YINA
Sbjct: 1640 ELEFKLL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINA 1697
Query: 1259 ALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENG 1316
+ +D Y+Q A+I TQ PL + +DFWR++ +++ T +VML + + C QYWP
Sbjct: 1698 SFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWP--- 1754
Query: 1317 VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKR 1375
R Q V E ++ I R + +DG R ++QFQF WP + P +
Sbjct: 1755 AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWP-EQGVPKTGE 1813
Query: 1376 SFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVK 1435
F+ I QV K +E++ G +G VHC G GR+G F +SIV E +R++ VD+F VK
Sbjct: 1814 GFIDFIGQVHKTKEQF-GQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVK 1872
Query: 1436 TLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464
TLR +P MV DQY+ CY ALEYL S
Sbjct: 1873 TLRTQRPAMVQTEDQYQLCYRAALEYLGS 1901
Score = 137 bits (346), Expect = 6e-32
Identities = 82/245 (33%), Positives = 126/245 (51%), Gaps = 13/245 (5%)
Query: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284
N KNR +++ D L +IDG S+YINA +D Y++ +A+I TQ PLP T+ DF
Sbjct: 1375 NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDF 1434
Query: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342
WR+V + +VVM+ ++ C QYWP G G IQV + R F
Sbjct: 1435 WRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFA 1494
Query: 1343 IYNAARPQDGYRMVQQFQFLGWPMYR--DTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVV 1400
++ + + R ++QFQF+ WP + + P +FL+ ++ + G VV
Sbjct: 1495 LHKSGSSEK--RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDA------GPMVV 1546
Query: 1401 HCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE 1460
HC G GR+G F I + E ++H++TVD++ V +R+ + MV DQY F +E LE
Sbjct: 1547 HCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1606
Query: 1461 YLNSG 1465
G
Sbjct: 1607 AATCG 1611
Score = 81.6 bits (200), Expect = 5e-15
Identities = 104/442 (23%), Positives = 175/442 (39%), Gaps = 46/442 (10%)
Query: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRD 254
EV G C A+G + + W+ G + KE ++ R + NVV +
Sbjct: 242 EVMPGGSVNLTCVAVGAPMPYVK-WMMGAEELT---KEDEMPVGRNVLELSNVVRSAN-- 295
Query: 255 AGKYRCMIRTEGGVGISNYAELVVK---EPPVPIAPPQLASVGATYLWIQLNANSINGDG 311
Y C+ + G+ I A++ VK +PP+ + + + T W N+
Sbjct: 296 ---YTCVAISSLGM-IEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSE------ 345
Query: 312 PIVAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPA 369
P+ ++Y A G + + V +T Y IG L P +EY VL G G P A
Sbjct: 346 PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN--SIGRGPPSEA 403
Query: 370 LRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQV 429
+R RT P PR+++ + + + ++WEP Y V+Y +
Sbjct: 404 VRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYR--VYYT-----PDSR 456
Query: 430 REEVSWDTENSHP--QHTITNLSPYTNVSVKLILMNPEG-RKESQELIVQTDEDLPGAVP 486
R +W N+ T+ +L P S++++ G S + V+T + +P A P
Sbjct: 457 RPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQP 515
Query: 487 TESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNET 546
+ + +I L W P Q I +YE+ Y A D + ++ +
Sbjct: 516 ADFQAEVESDTRIQLSWLLPPQER--IIMYELVYWAAEDEDQQHKVT--------FDPTS 565
Query: 547 HFLFFGLYPGTTYSFTIRASTAKGFGP-PATNQFTTKISAPSMPAYELE-TPLNQTDNTV 604
+ L P T Y F + A + G G T + T S PS P ++ + T V
Sbjct: 566 SYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRV 625
Query: 605 TVMLKPAHSRGAPVSVYQIVVE 626
+ + PA SR ++ Y + E
Sbjct: 626 SWVPPPADSRNGVITQYSVAYE 647
Score = 63.5 bits (153), Expect = 1e-09
Identities = 87/366 (23%), Positives = 135/366 (36%), Gaps = 60/366 (16%)
Query: 257 KYRCMIR--TEGGVGISNYAELVVKEPPVPIAPPQLASVG-----ATYLWIQLNANSING 309
+YR +R T+ G G + LV + VP PP+ V A +++ +L S
Sbjct: 679 EYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPS-KQ 737
Query: 310 DGPIVAREVEYCT-----------------ASGSWNDRQPVDSTSYK--IGHLDPDTEYE 350
G I +V Y A W +P +S Y+ I L P+T Y
Sbjct: 738 HGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQW---RPEESEDYETTISGLTPETTYS 794
Query: 351 ISVLL-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTR 409
++V T G+G P T + G + + ++W P
Sbjct: 795 VTVAAYTTKGDGARSKPKIVTTTGA-----VPGRPTMMISTTAMNTALLQWHPPKELPGE 849
Query: 410 CHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE 469
Y L YC E + + ++ H T+T L T +L N G E
Sbjct: 850 LLGYRL--QYCR---ADEARPNTIDFGKDDQH--FTVTGLHKGTTYIFRLAAKNRAGLGE 902
Query: 470 SQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFD 527
E ++T EDLP P L W P + G I Y + ++ ++S
Sbjct: 903 EFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS-- 960
Query: 528 PEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPS 587
+ +L N + +T F GL P TTY +RA T+KG GP + I + +
Sbjct: 961 -QQELQN-------ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGP-----LSPSIQSRT 1007
Query: 588 MPAYEL 593
MP ++
Sbjct: 1008 MPVEQV 1013
Score = 53.9 bits (128), Expect = 1e-06
Identities = 88/441 (19%), Positives = 162/441 (36%), Gaps = 97/441 (21%)
Query: 379 PMRGPRKLEVVEVKSRQITIRWEP--FGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWD 436
P P+ L V + + + W+P R SY + + Q+++ + ++ D
Sbjct: 915 PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR---DINSQQEL-QNITTD 970
Query: 437 TENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFE 496
T + T+T L P T +K+ +G I + + +
Sbjct: 971 T-----RFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1025
Query: 497 EKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPG 556
+ L W P +Y ++I Y S E+D G+ L L P
Sbjct: 1026 TSVLLSWEVP-DSYKSAVPFKILYNGQSV---EVD-----------GHSMRKLIADLQPN 1070
Query: 557 TTYSFTI--RASTAKGFGP----------------PATNQFTTKISAPSMPA-------- 590
T YSF + R S+A G PA+ SMP
Sbjct: 1071 TEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVR 1130
Query: 591 --YELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIV--VEE--ERPRRTKKTTEILKCYP 644
Y + P+++ + ML P S + + +++ +E+ E RR ++ E LK Y
Sbjct: 1131 WFYIVVVPIDRVGGS---MLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPY- 1186
Query: 645 VPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQA 704
AA+ + FT+GD K Y G++N PL P SY+ + A
Sbjct: 1187 ----------------VAAQLDV----LPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLA 1226
Query: 705 ASRANGETKIDCVQVATKGAATP-------KPVPEPEKQTDHTVKIAGVIAGILLFVIIF 757
+ + + K + A++P + P +++ + + G + ++L ++I
Sbjct: 1227 SLKEPMDQK--------RYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIV 1278
Query: 758 LGVVLVMKKRKLAKKRKETMS 778
+ ++L +KR + K+ S
Sbjct: 1279 IAILLFKRKRTHSPSSKDEQS 1299
Score = 49.3 bits (116), Expect = 3e-05
Identities = 70/300 (23%), Positives = 113/300 (37%), Gaps = 25/300 (8%)
Query: 340 IGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIR 399
+G L P Y + VL G G P P ++ +T+ P + P + +I +
Sbjct: 475 VGSLLPGITYSLRVLAFTAV--GDGPPSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLS 531
Query: 400 WEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKL 459
W + + Y E + +V++D +S+ T+ +L P T +L
Sbjct: 532 W------LLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSY---TLEDLKPDTLYRFQL 582
Query: 460 ILMNPEGRKESQELI-VQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLY 516
+ G I +T + P A P + + S + + W P GVIT Y
Sbjct: 583 AARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQY 642
Query: 517 EITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPAT 576
+ Y+AV D + + R + + GL T Y +RA T G GP ++
Sbjct: 643 SVAYEAVDGEDRGRHVVDGISR-----EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESS 697
Query: 577 NQFT-TKISAPSMPAYELET-PLNQTDNTVTVMLKPAHSRGAPVSVYQIV---VEEERPR 631
T PS P ++E PLN T V L + + YQ+ +E PR
Sbjct: 698 PVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPR 757
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 498 bits (1281), Expect = e-140
Identities = 279/629 (44%), Positives = 382/629 (60%), Gaps = 20/629 (3%)
Query: 849 AILVPINDETHTMAS-DTSSL-----VQSHTYKKREPADVPYQTGQL--HPAIRVADLLQ 900
AIL+ TH+ +S D S+ + +H+ E + YQT + HP I + DL
Sbjct: 1271 AILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLAD 1330
Query: 901 HITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEG 960
+I ++K +G F +EYES GQ W+++ + N+ KNRY N+IAYDHSRV L +I+G
Sbjct: 1331 NIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDG 1390
Query: 961 DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVK 1020
SDYIN NYIDGY + N YIATQGP+ ET+ DFWRMVW + TA+++M+T L E RVK
Sbjct: 1391 VPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVK 1450
Query: 1021 CCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGV 1079
C +YWP TE I+VTL++T LA Y +RTFA+ K G E RE+RQF F WPDHGV
Sbjct: 1451 CDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGV 1510
Query: 1080 PYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNC 1139
P + T +L F+R+VK+ +P AGP+VVHCSAG GRTGCFIVID ML+ + E VDIY
Sbjct: 1511 PEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGH 1570
Query: 1140 VRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQI 1199
V +RS+R MVQTE+QYVFIH+A+LEA CG T VPA + + + ++ P + + +
Sbjct: 1571 VTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAM 1630
Query: 1200 KEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINA 1258
+ EF+ L + A LP N KNR ++I+P + L I G E S+YINA
Sbjct: 1631 ELEFKLL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINA 1688
Query: 1259 ALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENG 1316
+ +D Y+Q A+I TQ PL + +DFWR++ +++ T +VML + + C QYWP
Sbjct: 1689 SFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWP--- 1745
Query: 1317 VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKR 1375
R Q V E ++ I R + +DG R ++QFQF WP + P +
Sbjct: 1746 AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWP-EQGVPKTGE 1804
Query: 1376 SFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVK 1435
F+ I QV K +E++ G +G VHC G GR+G F +SIV E +R++ VD+F VK
Sbjct: 1805 GFIDFIGQVHKTKEQF-GQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVK 1863
Query: 1436 TLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464
TLR +P MV DQY+ CY ALEYL S
Sbjct: 1864 TLRTQRPAMVQTEDQYQLCYRAALEYLGS 1892
Score = 137 bits (346), Expect = 6e-32
Identities = 82/245 (33%), Positives = 126/245 (51%), Gaps = 13/245 (5%)
Query: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284
N KNR +++ D L +IDG S+YINA +D Y++ +A+I TQ PLP T+ DF
Sbjct: 1366 NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDF 1425
Query: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342
WR+V + +VVM+ ++ C QYWP G G IQV + R F
Sbjct: 1426 WRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFA 1485
Query: 1343 IYNAARPQDGYRMVQQFQFLGWPMYR--DTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVV 1400
++ + + R ++QFQF+ WP + + P +FL+ ++ + G VV
Sbjct: 1486 LHKSGSSEK--RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDA------GPMVV 1537
Query: 1401 HCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE 1460
HC G GR+G F I + E ++H++TVD++ V +R+ + MV DQY F +E LE
Sbjct: 1538 HCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1597
Query: 1461 YLNSG 1465
G
Sbjct: 1598 AATCG 1602
Score = 81.6 bits (200), Expect = 5e-15
Identities = 104/442 (23%), Positives = 175/442 (39%), Gaps = 46/442 (10%)
Query: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRD 254
EV G C A+G + + W+ G + KE ++ R + NVV +
Sbjct: 242 EVMPGGSVNLTCVAVGAPMPYVK-WMMGAEELT---KEDEMPVGRNVLELSNVVRSAN-- 295
Query: 255 AGKYRCMIRTEGGVGISNYAELVVK---EPPVPIAPPQLASVGATYLWIQLNANSINGDG 311
Y C+ + G+ I A++ VK +PP+ + + + T W N+
Sbjct: 296 ---YTCVAISSLGM-IEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSE------ 345
Query: 312 PIVAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPA 369
P+ ++Y A G + + V +T Y IG L P +EY VL G G P A
Sbjct: 346 PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN--SIGRGPPSEA 403
Query: 370 LRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQV 429
+R RT P PR+++ + + + ++WEP Y V+Y +
Sbjct: 404 VRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYR--VYYT-----PDSR 456
Query: 430 REEVSWDTENSHP--QHTITNLSPYTNVSVKLILMNPEG-RKESQELIVQTDEDLPGAVP 486
R +W N+ T+ +L P S++++ G S + V+T + +P A P
Sbjct: 457 RPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQP 515
Query: 487 TESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNET 546
+ + +I L W P Q I +YE+ Y A D + ++ +
Sbjct: 516 ADFQAEVESDTRIQLSWLLPPQER--IIMYELVYWAAEDEDQQHKVT--------FDPTS 565
Query: 547 HFLFFGLYPGTTYSFTIRASTAKGFGP-PATNQFTTKISAPSMPAYELE-TPLNQTDNTV 604
+ L P T Y F + A + G G T + T S PS P ++ + T V
Sbjct: 566 SYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRV 625
Query: 605 TVMLKPAHSRGAPVSVYQIVVE 626
+ + PA SR ++ Y + E
Sbjct: 626 SWVPPPADSRNGVITQYSVAYE 647
Score = 63.5 bits (153), Expect = 1e-09
Identities = 83/354 (23%), Positives = 131/354 (37%), Gaps = 45/354 (12%)
Query: 257 KYRCMIR--TEGGVGISNYAELVVKEPPVPIAPPQLASVG-----ATYLWIQLNANSING 309
+YR +R T+ G G + LV + VP PP+ V A +++ +L S
Sbjct: 679 EYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPS-KQ 737
Query: 310 DGPIVAREVEYCTASGSWNDRQPV-------DSTSYKIGHLDPDTEYEISVLL-TRPGEG 361
G I +V Y P+ ++ I L P+T Y ++V T G+G
Sbjct: 738 HGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDG 797
Query: 362 GTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCY 421
P T + G + + ++W P Y L YC
Sbjct: 798 ARSKPKIVTTTGA-----VPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRL--QYCR 850
Query: 422 QVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDL 481
E + + ++ H T+T L T +L N G E E ++T EDL
Sbjct: 851 ---ADEARPNTIDFGKDDQH--FTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDL 905
Query: 482 PGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEIDLSNQSGRV 539
P P L W P + G I Y + ++ ++S + +L N
Sbjct: 906 PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS---QQELQN----- 957
Query: 540 SKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYEL 593
+ +T F GL P TTY +RA T+KG GP + I + +MP ++
Sbjct: 958 --ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGP-----LSPSIQSRTMPVEQV 1004
Score = 53.9 bits (128), Expect = 1e-06
Identities = 88/441 (19%), Positives = 162/441 (36%), Gaps = 97/441 (21%)
Query: 379 PMRGPRKLEVVEVKSRQITIRWEP--FGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWD 436
P P+ L V + + + W+P R SY + + Q+++ + ++ D
Sbjct: 906 PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR---DINSQQEL-QNITTD 961
Query: 437 TENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFE 496
T + T+T L P T +K+ +G I + + +
Sbjct: 962 T-----RFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1016
Query: 497 EKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPG 556
+ L W P +Y ++I Y S E+D G+ L L P
Sbjct: 1017 TSVLLSWEVP-DSYKSAVPFKILYNGQSV---EVD-----------GHSMRKLIADLQPN 1061
Query: 557 TTYSFTI--RASTAKGFGP----------------PATNQFTTKISAPSMPA-------- 590
T YSF + R S+A G PA+ SMP
Sbjct: 1062 TEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVR 1121
Query: 591 --YELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIV--VEE--ERPRRTKKTTEILKCYP 644
Y + P+++ + ML P S + + +++ +E+ E RR ++ E LK Y
Sbjct: 1122 WFYIVVVPIDRVGGS---MLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPY- 1177
Query: 645 VPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQA 704
AA+ + FT+GD K Y G++N PL P SY+ + A
Sbjct: 1178 ----------------VAAQLDV----LPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLA 1217
Query: 705 ASRANGETKIDCVQVATKGAATP-------KPVPEPEKQTDHTVKIAGVIAGILLFVIIF 757
+ + + K + A++P + P +++ + + G + ++L ++I
Sbjct: 1218 SLKEPMDQK--------RYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIV 1269
Query: 758 LGVVLVMKKRKLAKKRKETMS 778
+ ++L +KR + K+ S
Sbjct: 1270 IAILLFKRKRTHSPSSKDEQS 1290
Score = 49.3 bits (116), Expect = 3e-05
Identities = 70/300 (23%), Positives = 113/300 (37%), Gaps = 25/300 (8%)
Query: 340 IGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIR 399
+G L P Y + VL G G P P ++ +T+ P + P + +I +
Sbjct: 475 VGSLLPGITYSLRVLAFTAV--GDGPPSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLS 531
Query: 400 WEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKL 459
W + + Y E + +V++D +S+ T+ +L P T +L
Sbjct: 532 W------LLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSY---TLEDLKPDTLYRFQL 582
Query: 460 ILMNPEGRKESQELI-VQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLY 516
+ G I +T + P A P + + S + + W P GVIT Y
Sbjct: 583 AARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQY 642
Query: 517 EITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPAT 576
+ Y+AV D + + R + + GL T Y +RA T G GP ++
Sbjct: 643 SVAYEAVDGEDRGRHVVDGISR-----EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESS 697
Query: 577 NQFT-TKISAPSMPAYELET-PLNQTDNTVTVMLKPAHSRGAPVSVYQIV---VEEERPR 631
T PS P ++E PLN T V L + + YQ+ +E PR
Sbjct: 698 PVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPR 757
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 497 bits (1280), Expect = e-140
Identities = 272/594 (45%), Positives = 368/594 (61%), Gaps = 15/594 (2%)
Query: 877 REPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDEN 936
REP +++ HP I +AD+ +H ++K + +EYES GQ W+ + + N
Sbjct: 1358 REPG-FHFESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVN 1416
Query: 937 RMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFW 996
+ KNRY N+IAYDHSRV LQ IEG SDYIN NY+DGY N YIATQGP+ ET DFW
Sbjct: 1417 KPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFW 1476
Query: 997 RMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAV 1055
RMVW + +A+I+M+T L E R+KC +YWP+ TE Y I+VTL++T LA + +RTF++
Sbjct: 1477 RMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSL 1536
Query: 1056 EKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRT 1115
K G E RE+RQF FT WPDHGVP + T L F+R+VK+ +PP AGP+VVHCSAG GRT
Sbjct: 1537 HKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRT 1596
Query: 1116 GCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSV 1175
GCFIVID ML+ + E VD+Y V +RS+R MVQTE+QY FIH+A+LEA CG+T V
Sbjct: 1597 GCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1656
Query: 1176 PASQVRSLYYDMNKLDPQTNSSQIKEEFRTL-NMVTPTLRVEDCSIALLPRNHEKNRCMD 1234
PA + + + +++P + + ++ EF+ L N T R A LP N KNR ++
Sbjct: 1657 PARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS---ANLPCNKFKNRLVN 1713
Query: 1235 ILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHC 1293
I+P + L I G E S+YINA+ +D Y+Q A+I TQ PL T +DFWR++ + +
Sbjct: 1714 IMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNS 1773
Query: 1294 TSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQD 1351
T VVML + + C QYWP R Q V E ++ I R + +D
Sbjct: 1774 TIVVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARD 1830
Query: 1352 GY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSG 1410
G R V+QFQF WP + P S F+ I QV K +E++ G +G VHC G GR+G
Sbjct: 1831 GQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTG 1888
Query: 1411 TFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464
F +SIV E +R++ VD+F VK LR +P MV D+Y+FCY+ ALEYL S
Sbjct: 1889 VFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1942
Score = 133 bits (334), Expect = 1e-30
Identities = 83/243 (34%), Positives = 120/243 (49%), Gaps = 9/243 (3%)
Query: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284
N KNR +++ D L I+G S+YINA +D Y+ +A+I TQ PLP T DF
Sbjct: 1416 NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF 1475
Query: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342
WR+V + ++VM+ ++ C QYWP G +G IQV + R F
Sbjct: 1476 WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFS 1535
Query: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402
++ + R V+QFQF WP + P FL +R+V G VVHC
Sbjct: 1536 LHKNGSSEK--REVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNPP---DAGPIVVHC 1589
Query: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462
G GR+G F I + E ++ ++TVDV+ V +R+ + MV DQY F +E LE +
Sbjct: 1590 SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1649
Query: 1463 NSG 1465
G
Sbjct: 1650 GCG 1652
Score = 79.3 bits (194), Expect = 2e-14
Identities = 100/408 (24%), Positives = 172/408 (42%), Gaps = 44/408 (10%)
Query: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK-R 253
E+ G C A+G + + W+QG + +T NV+ T +
Sbjct: 255 EIMPGGNVNITCVAVGSPMPYVK-WMQGAE---------DLTPEDDMPVGRNVLELTDVK 304
Query: 254 DAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPI 313
D+ Y C+ + GV I A++ VK P P + AT + I ++ + + P+
Sbjct: 305 DSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPD---PV 360
Query: 314 VAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALR 371
+EY + S G + ++ + +T Y IG L P++EYEI V + G G P ++
Sbjct: 361 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVV 418
Query: 372 TRTKCADPMRGPRKLEVVEVKSRQITIRW-EPFGYN-VTRCHSYNLTVHYCYQVGGQEQV 429
TRT P PR ++ + + + ++W EP N + R + T+ + VG ++
Sbjct: 419 TRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKH 478
Query: 430 REEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTE 488
+ S T T+ +L +V+++ G S + V+T + +PG P
Sbjct: 479 NVDDSLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMN 530
Query: 489 SIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHF 548
+ E I L W P Q I YE+ ++ E D + GR T +
Sbjct: 531 LRAEARSETSITLSWSPPRQE--SIIKYELLFR-------EGDHGREVGRT--FDPTTSY 579
Query: 549 LFFGLYPGTTYSFTIRASTAKGFG--PPATNQFTTKISAPSMPAYELE 594
+ L P T Y+F + A + +G G P Q T + S PS P +++
Sbjct: 580 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ-SKPSAPPQDVK 626
Score = 69.3 bits (168), Expect = 3e-11
Identities = 63/248 (25%), Positives = 105/248 (42%), Gaps = 15/248 (6%)
Query: 335 STSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSR 394
+TSY + L P+TEY + P G G+ P +R RT + P P+ ++ V V+S
Sbjct: 576 TTSYVVEDLKPNTEYAFRLAARSPQ--GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRST 633
Query: 395 QITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTN 454
I + W P +V Y +G ++ +EV+ + Q + L +T
Sbjct: 634 AILVSWRPPPPETHNGALVGYSVRY-RPLGSEDPEPKEVN-GIPPTTTQILLEALEKWTQ 691
Query: 455 VSVKLILMNPEG-RKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYG 511
+ + G ES ++V+TDED+P A P + + I + WR P + +G
Sbjct: 692 YRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHG 751
Query: 512 VITLYEITYKAVSSFD-------PEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIR 564
I Y++ Y + + ++ L++ E + L P T YS T+
Sbjct: 752 QIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTA-EYEMVITNLQPETAYSITVA 810
Query: 565 ASTAKGFG 572
A T KG G
Sbjct: 811 AYTMKGDG 818
Score = 56.6 bits (135), Expect = 2e-07
Identities = 78/326 (23%), Positives = 125/326 (38%), Gaps = 35/326 (10%)
Query: 332 PVDSTSYKIGHLDPDTEYEISVLL-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVE 390
P +T + L+ T+Y I+ + T G G SP + RT P PRK+E
Sbjct: 675 PPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSP---VVVRTDEDVPSAPPRKVEAEA 731
Query: 391 VKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVG----GQEQVRE----EVSWDTENSHP 442
+ + I + W VHY G G ++++ + W+T+++
Sbjct: 732 LNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAE 791
Query: 443 -QHTITNLSPYT--NVSVKLILMNPEGRKESQELIVQTDEDLPGAV---PTESIQGSTFE 496
+ ITNL P T +++V M +G + +++V GAV PT S+Q T E
Sbjct: 792 YEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTK-----GAVLGRPTLSVQ-QTPE 845
Query: 497 EKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPG 556
+ +W P G + Y+ + L+ S E + G++ G
Sbjct: 846 GSLLARWEPPA---GTAEDQVLGYRLQFGREDSTPLATLEFPPS----EDRYTASGVHKG 898
Query: 557 TTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVML---KPAHS 613
TY F + A + G G A + P LE N + TV + PA
Sbjct: 899 ATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAER 958
Query: 614 RGAPVSVYQIVVEEERPRRTKKTTEI 639
GA V Y + V E + TE+
Sbjct: 959 NGAIVK-YTVAVREAGALGPARETEL 983
Score = 52.8 bits (125), Expect = 2e-06
Identities = 79/341 (23%), Positives = 121/341 (35%), Gaps = 51/341 (14%)
Query: 264 TEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSIN----------GDGPI 313
TE G G + +V + VP APP+ A LNA +I G I
Sbjct: 700 TEVGPGPESSPVVVRTDEDVPSAPPRKVEAEA------LNATAIRVLWRSPAPGRQHGQI 753
Query: 314 VAREVEYCTASGSWNDRQPV--------------DSTSYK--IGHLDPDTEYEISVLL-T 356
+V Y G+ P D+ Y+ I +L P+T Y I+V T
Sbjct: 754 RGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYT 813
Query: 357 RPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEP-FGYNVTRCHSYNL 415
G+G P + TK A + G L V + + RWEP G + Y L
Sbjct: 814 MKGDGARSKPKVVV---TKGA--VLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRL 868
Query: 416 TVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIV 475
G+E + + S ++T + + +L + G E ++
Sbjct: 869 QF-------GREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVL 921
Query: 476 QTDEDLPGAVPTE-SIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEIDL 532
ED P P G+ + L+W P + G I Y + + + P +
Sbjct: 922 SIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARE- 980
Query: 533 SNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGP 573
+ ++ G E GL P T Y +RA T +G GP
Sbjct: 981 -TELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGP 1020
Score = 38.5 bits (88), Expect = 0.048
Identities = 73/305 (23%), Positives = 111/305 (36%), Gaps = 54/305 (17%)
Query: 499 IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTT 558
+ L W P Y T Y+I Y ++ ++D G T L L P T
Sbjct: 1050 VLLSWEFP-DNYNSPTPYKIQYNGLTL---DVD-----------GRTTKKLITHLKPHTF 1094
Query: 559 YSFTI--RASTAKGFGPPAT--NQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614
Y+F + R S+ G T F PS+ P D + V L S
Sbjct: 1095 YNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQSP 1148
Query: 615 GAPVSVYQIVVEEERPRR---------TKKTTEILKCYPVPIHFQNASLLNSQY------ 659
PV Y IV+ R R + + ++ + Q SL +S+
Sbjct: 1149 -VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRP 1207
Query: 660 YFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQV 719
Y AA F F GD K Y G+ N L P Y ++ A + + T
Sbjct: 1208 YIAARFSV----LPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT------F 1257
Query: 720 ATKGAATPKPV--PEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKET 776
A + P + P+P+ D + VI +L V II + + +++ K K KRK++
Sbjct: 1258 AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS 1317
Query: 777 MSSTR 781
T+
Sbjct: 1318 EPRTK 1322
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 440 bits (1131), Expect = e-123
Identities = 235/601 (39%), Positives = 361/601 (60%), Gaps = 21/601 (3%)
Query: 878 EPADVPY-----QTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQ-SAPWDSA 931
EP VP T + +P + V L + I + + F+EE+ + A ++A
Sbjct: 192 EPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAA 251
Query: 932 KKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQET 991
K+EN+ KNRY NI+ YDHSRV L +EG +SDYIN ++I+GY N +IA QGP +ET
Sbjct: 252 SKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEET 311
Query: 992 IYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAEYVI 1050
+ DFWRM+W +NTA+I+MVTNL E KC +YWPD Y +I+V++ + +L +Y +
Sbjct: 312 VNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTV 371
Query: 1051 RTFAVEKRGVHEIRE----IRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVV 1106
R F +++ G R+ I QFHFT WPD GVP+ G+L F+++VK+ +P AG +VV
Sbjct: 372 RKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVV 431
Query: 1107 HCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1166
HCSAG GRTG F+VID MLDM E VD+Y V +R++R MVQT+ QYVFI+ A+LE
Sbjct: 432 HCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE 491
Query: 1167 ACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRN 1226
L GDT + + + + + P T+++ ++EEF+ L + ++ + LP N
Sbjct: 492 HYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPAN 549
Query: 1227 HEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFW 1285
+KNR + I+P + + G E+++Y+NA+ +D Y+Q ++I +Q PL +T++DFW
Sbjct: 550 MKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFW 609
Query: 1286 RLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRI 1343
R++ ++ S+VML +++ + C QYWP +G+ +G I VE + E R +
Sbjct: 610 RMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLV 669
Query: 1344 YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCL 1403
N ++ R ++QF F GWP P + + +I V K Q++ G VHC
Sbjct: 670 TNTR--ENKSRQIRQFHFHGWPEV-GIPSDGKGMISIIAAVQKQQQQ--SGNHPITVHCS 724
Query: 1404 NGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN 1463
G GR+GTFCA+S V E ++ + +DVF VK+LR +P+MV L+QY+FCY+V EY++
Sbjct: 725 AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
Query: 1464 S 1464
+
Sbjct: 785 A 785
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 440 bits (1131), Expect = e-123
Identities = 235/601 (39%), Positives = 361/601 (60%), Gaps = 21/601 (3%)
Query: 878 EPADVPY-----QTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQ-SAPWDSA 931
EP VP T + +P + V L + I + + F+EE+ + A ++A
Sbjct: 201 EPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAA 260
Query: 932 KKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQET 991
K+EN+ KNRY NI+ YDHSRV L +EG +SDYIN ++I+GY N +IA QGP +ET
Sbjct: 261 SKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEET 320
Query: 992 IYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAEYVI 1050
+ DFWRM+W +NTA+I+MVTNL E KC +YWPD Y +I+V++ + +L +Y +
Sbjct: 321 VNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTV 380
Query: 1051 RTFAVEKRGVHEIRE----IRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVV 1106
R F +++ G R+ I QFHFT WPD GVP+ G+L F+++VK+ +P AG +VV
Sbjct: 381 RKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVV 440
Query: 1107 HCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1166
HCSAG GRTG F+VID MLDM E VD+Y V +R++R MVQT+ QYVFI+ A+LE
Sbjct: 441 HCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE 500
Query: 1167 ACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRN 1226
L GDT + + + + + P T+++ ++EEF+ L + ++ + LP N
Sbjct: 501 HYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPAN 558
Query: 1227 HEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFW 1285
+KNR + I+P + + G E+++Y+NA+ +D Y+Q ++I +Q PL +T++DFW
Sbjct: 559 MKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFW 618
Query: 1286 RLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRI 1343
R++ ++ S+VML +++ + C QYWP +G+ +G I VE + E R +
Sbjct: 619 RMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLV 678
Query: 1344 YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCL 1403
N ++ R ++QF F GWP P + + +I V K Q++ G VHC
Sbjct: 679 TNTR--ENKSRQIRQFHFHGWPEV-GIPSDGKGMISIIAAVQKQQQQ--SGNHPITVHCS 733
Query: 1404 NGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN 1463
G GR+GTFCA+S V E ++ + +DVF VK+LR +P+MV L+QY+FCY+V EY++
Sbjct: 734 AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 793
Query: 1464 S 1464
+
Sbjct: 794 A 794
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 440 bits (1131), Expect = e-123
Identities = 235/601 (39%), Positives = 361/601 (60%), Gaps = 21/601 (3%)
Query: 878 EPADVPY-----QTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQ-SAPWDSA 931
EP VP T + +P + V L + I + + F+EE+ + A ++A
Sbjct: 192 EPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAA 251
Query: 932 KKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQET 991
K+EN+ KNRY NI+ YDHSRV L +EG +SDYIN ++I+GY N +IA QGP +ET
Sbjct: 252 SKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEET 311
Query: 992 IYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAEYVI 1050
+ DFWRM+W +NTA+I+MVTNL E KC +YWPD Y +I+V++ + +L +Y +
Sbjct: 312 VNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTV 371
Query: 1051 RTFAVEKRGVHEIRE----IRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVV 1106
R F +++ G R+ I QFHFT WPD GVP+ G+L F+++VK+ +P AG +VV
Sbjct: 372 RKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVV 431
Query: 1107 HCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1166
HCSAG GRTG F+VID MLDM E VD+Y V +R++R MVQT+ QYVFI+ A+LE
Sbjct: 432 HCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE 491
Query: 1167 ACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRN 1226
L GDT + + + + + P T+++ ++EEF+ L + ++ + LP N
Sbjct: 492 HYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPAN 549
Query: 1227 HEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFW 1285
+KNR + I+P + + G E+++Y+NA+ +D Y+Q ++I +Q PL +T++DFW
Sbjct: 550 MKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFW 609
Query: 1286 RLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRI 1343
R++ ++ S+VML +++ + C QYWP +G+ +G I VE + E R +
Sbjct: 610 RMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLV 669
Query: 1344 YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCL 1403
N ++ R ++QF F GWP P + + +I V K Q++ G VHC
Sbjct: 670 TNTR--ENKSRQIRQFHFHGWPEV-GIPSDGKGMISIIAAVQKQQQQ--SGNHPITVHCS 724
Query: 1404 NGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN 1463
G GR+GTFCA+S V E ++ + +DVF VK+LR +P+MV L+QY+FCY+V EY++
Sbjct: 725 AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
Query: 1464 S 1464
+
Sbjct: 785 A 785
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 423 bits (1087), Expect = e-118
Identities = 235/562 (41%), Positives = 333/562 (59%), Gaps = 16/562 (2%)
Query: 913 FKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNY 971
F+EE+ S G ++ A K+ENR KNRY NI+ DHSRV L ++G SDYIN +Y
Sbjct: 135 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 194
Query: 972 IDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TE 1030
IDGY N +IA QGP QET+ DFWRMVW + +A+I+M+TNL E KC +YWPD
Sbjct: 195 IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 254
Query: 1031 IYKDIKVTLIETELLAEYVIRTFAVEKR---GVHEIREIRQFHFTGWPDHGVPYHATGLL 1087
Y +I+V + + +L +Y IR F ++ + G R + Q HFT WPD GVP+ G+L
Sbjct: 255 TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 314
Query: 1088 GFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRR 1147
F+++VK+ +P AGP+VVHCSAG GRTG FIVID M+ M E VD++ V +R++R
Sbjct: 315 KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 374
Query: 1148 VNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLN 1207
MVQT+ QY FI+ A+LE L GDT + S + M+ + ++EEFR L
Sbjct: 375 PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 434
Query: 1208 MVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQ 1266
V + E+ LP N +K R + I+P D L G E ++YINA+ +D Y+Q
Sbjct: 435 NV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 492
Query: 1267 PSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWPENGVHRHGPIQ 1324
FI TQ PL +TV+DFWR++ ++ ++VML +V + C QYWP G HG I
Sbjct: 493 KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEIT 552
Query: 1325 VEFVSADLEEDIISRIFRI---YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLI 1381
+E + L E I R F + AR ++ R+V+QF F GWP P + + LI
Sbjct: 553 IEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDLI 611
Query: 1382 RQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNK 1441
V K Q++ G VHC G GR+GTF A+S + E ++ + +DVF AVK+LR +
Sbjct: 612 AAVQKQQQQ--TGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQR 669
Query: 1442 PNMVDLLDQYKFCYEVALEYLN 1463
P+MV L+QY+FCY+V ++++
Sbjct: 670 PHMVQTLEQYEFCYKVVQDFID 691
>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
[Homo sapiens]
Length = 642
Score = 423 bits (1087), Expect = e-118
Identities = 235/562 (41%), Positives = 333/562 (59%), Gaps = 16/562 (2%)
Query: 913 FKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNY 971
F+EE+ S G ++ A K+ENR KNRY NI+ DHSRV L ++G SDYIN +Y
Sbjct: 77 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 136
Query: 972 IDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TE 1030
IDGY N +IA QGP QET+ DFWRMVW + +A+I+M+TNL E KC +YWPD
Sbjct: 137 IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 196
Query: 1031 IYKDIKVTLIETELLAEYVIRTFAVEKR---GVHEIREIRQFHFTGWPDHGVPYHATGLL 1087
Y +I+V + + +L +Y IR F ++ + G R + Q HFT WPD GVP+ G+L
Sbjct: 197 TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 256
Query: 1088 GFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRR 1147
F+++VK+ +P AGP+VVHCSAG GRTG FIVID M+ M E VD++ V +R++R
Sbjct: 257 KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 316
Query: 1148 VNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLN 1207
MVQT+ QY FI+ A+LE L GDT + S + M+ + ++EEFR L
Sbjct: 317 PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 376
Query: 1208 MVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQ 1266
V + E+ LP N +K R + I+P D L G E ++YINA+ +D Y+Q
Sbjct: 377 NV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 434
Query: 1267 PSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWPENGVHRHGPIQ 1324
FI TQ PL +TV+DFWR++ ++ ++VML +V + C QYWP G HG I
Sbjct: 435 KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEIT 494
Query: 1325 VEFVSADLEEDIISRIFRI---YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLI 1381
+E + L E I R F + AR ++ R+V+QF F GWP P + + LI
Sbjct: 495 IEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDLI 553
Query: 1382 RQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNK 1441
V K Q++ G VHC G GR+GTF A+S + E ++ + +DVF AVK+LR +
Sbjct: 554 AAVQKQQQQ--TGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQR 611
Query: 1442 PNMVDLLDQYKFCYEVALEYLN 1463
P+MV L+QY+FCY+V ++++
Sbjct: 612 PHMVQTLEQYEFCYKVVQDFID 633
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 377 bits (969), Expect = e-104
Identities = 228/603 (37%), Positives = 346/603 (57%), Gaps = 45/603 (7%)
Query: 892 AIRVADLLQHITQMKCAEGYGFKEEYES----FFEGQSAPWD------SAKKDENRMKNR 941
AI + +H+ + + G F EE+E+ + E QS D S+ +N+ KNR
Sbjct: 1698 AIPIKHFPKHVADLHASSG--FTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNR 1755
Query: 942 YGNIIAYDHSRVRL-QTIEGDTN-SDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMV 999
Y NI+AYDHSRV+L Q E D +DYIN NY+DGY+RP YIA QGP++ T DFWRM+
Sbjct: 1756 YINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMI 1815
Query: 1000 WHENTASIIMVTNLVEVGRVKCCKYWP-DDTEIYKDIKVTLIETELLAEYVIRTFAVE-- 1056
W N I+M+TNLVE GR KC +YWP D +E Y + VT ++LA Y +R F +
Sbjct: 1816 WEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNT 1875
Query: 1057 ------KRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSA 1110
++G R + Q+H+T WPD GVP ++ +L FVR+ + GP+VVHCSA
Sbjct: 1876 KIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSA 1935
Query: 1111 GAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLC 1170
G GRTG +IV+D ML + EG V+I+ ++ +RS+R +VQTEEQYVFIHD ++EA L
Sbjct: 1936 GVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS 1995
Query: 1171 GDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKN 1230
+T V S + + Y + + ++++++F+ L+ ++ D S AL N EKN
Sbjct: 1996 KETEVLDSHIHA-YVNALLIPGPAGKTKLEKQFQLLSQ--SNIQQSDYSAALKQCNREKN 2052
Query: 1231 RCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLD 1290
R I+P +R + ++ GE ++YINA+ + Y Q + FI+TQHPL +T+KDFWR++ D
Sbjct: 2053 RTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWD 2112
Query: 1291 YHCTSVVMLND-VDPAQLCPQYWPENGVHRHGPIQVEFVSADL---EEDIISR----IFR 1342
++ VVM+ D + A+ YWP ++ PI E L E +S I +
Sbjct: 2113 HNAQLVVMIPDGQNMAEDEFVYWP----NKDEPINCESFKVTLMAEEHKCLSNEEKLIIQ 2168
Query: 1343 IYNAARPQDGYRM-VQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVH 1401
+ QD Y + V+ FQ WP D+P+SK +LI + +EE +G +VH
Sbjct: 2169 DFILEATQDDYVLEVRHFQCPKWP-NPDSPISKT--FELISVI---KEEAANRDGPMIVH 2222
Query: 1402 CLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY 1461
+GG +GTFCA++ + L + +VDV+ K + +P + ++QY+F Y+V L
Sbjct: 2223 DEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL 2282
Query: 1462 LNS 1464
+++
Sbjct: 2283 VST 2285
Score = 130 bits (326), Expect = 1e-29
Identities = 82/269 (30%), Positives = 131/269 (48%), Gaps = 17/269 (6%)
Query: 924 QSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIA 983
Q + + +A K NR KNR +II + SRV + ++ G+ +DYIN +YI GY++ N +I
Sbjct: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFII 2094
Query: 984 TQGPMQETIYDFWRMVWHENTASIIMVT---NLVEVGRVKCCKYWPDDTEIY--KDIKVT 1038
TQ P+ TI DFWRM+W N ++M+ N+ E V YWP+ E + KVT
Sbjct: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV----YWPNKDEPINCESFKVT 2150
Query: 1039 LIETELLA-----EYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1093
L+ E + +I+ F +E + E+R F WP+ P T L + +
Sbjct: 2151 LMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFEL--ISVI 2208
Query: 1094 KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQT 1153
K ++ GP++VH G G F + ++ E+E VD+Y + + R +
Sbjct: 2209 KEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFAD 2268
Query: 1154 EEQYVFIHDAILEACLCGDTSVPASQVRS 1182
EQY F++ IL P++ + S
Sbjct: 2269 IEQYQFLYKVILSLVSTRQEENPSTSLDS 2297
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 368 bits (945), Expect = e-101
Identities = 220/599 (36%), Positives = 341/599 (56%), Gaps = 38/599 (6%)
Query: 892 AIRVADLLQHITQMKCAEGYGFKEEYESFFE---GQSAPWDSAKKDENRMKNRYGNIIAY 948
AI V ++HI ++ +GF E++E + + + EN+ KNRY NI+AY
Sbjct: 827 AIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAY 886
Query: 949 DHSRVRLQTIEG--DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTAS 1006
DHSRV+L+ + G +SDYIN NY+DGY++ YIATQGP++ T DFWRM+W +NT
Sbjct: 887 DHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGI 946
Query: 1007 IIMVTNLVEVGRVKCCKYWP-DDTEIYKDIKVTLIETELLAEYVIRTFAVEK-------- 1057
I+M+TNLVE GR KC +YWP +++E Y +I VTL T++ A Y +R F++
Sbjct: 947 IVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQK 1006
Query: 1058 ---RGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGR 1114
+G R + Q+H+T WPD GVP +A +L FVR+ + P GP++VHCSAG GR
Sbjct: 1007 GNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGR 1066
Query: 1115 TGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTS 1174
TG +IVID ML + + V++ ++ +R++R +VQTEEQY+FIHDA+LEA L +T
Sbjct: 1067 TGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE 1126
Query: 1175 VPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMD 1234
V ++Q+ S Y + + ++++++F+ + + +C A N EKNR
Sbjct: 1127 VSSNQLHS-YVNSILIPGVGGKTRLEKQFKLVTQC--NAKYVECFSAQKECNKEKNRNSS 1183
Query: 1235 ILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHC 1293
++P +R L + G + ++YINA+ + Y + + FI+TQHPLP+T KDFWR++ D++
Sbjct: 1184 VVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNA 1243
Query: 1294 TSVVMLNDVDP-AQLCPQYWPENGVHRH-GPIQVEFVSADL-----EEDIISRIFRIYNA 1346
+VML D A+ YWP + V +S D EE II F +
Sbjct: 1244 QIIVMLPDNQSLAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFIL--- 1300
Query: 1347 ARPQDGYRM-VQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNG 1405
QD Y + V+ FQ WP D P+S S +LI + +EE +G T+VH G
Sbjct: 1301 EATQDDYVLEVRHFQCPKWP-NPDAPIS--STFELINVI---KEEALTRDGPTIVHDEYG 1354
Query: 1406 GGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464
+G CA++ + + L ++ VDVF K + +P + ++QY+F Y+ L +++
Sbjct: 1355 AVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST 1413
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
precursor [Homo sapiens]
Length = 1256
Score = 347 bits (889), Expect = 6e-95
Identities = 211/598 (35%), Positives = 309/598 (51%), Gaps = 44/598 (7%)
Query: 896 ADLLQHITQMKCA-EGYGFKEEYESFFEGQSA-PWDSAKKDENRMKNRYGNIIAYDHSRV 953
AD+L + K A EG F E++S S P A+K N+ KNRY +I+ YD++RV
Sbjct: 585 ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRV 644
Query: 954 RLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNL 1013
L I GD S+YIN +YIDG+ P YIA QGP ET+ DFWRM+W + I+MVT
Sbjct: 645 ELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRC 704
Query: 1014 VEVGRVKCCKYWP---DDTEIYKDIKVTLIETELLAEYVIRTF-AVEKRGVHEIREIRQF 1069
E R KC +YWP + T + D+ V + + + +Y+I+ V K+ RE+
Sbjct: 705 EEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHI 764
Query: 1070 HFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAE 1129
FT WPDHGVP LL R+V + S +GP+VVHCSAG GRTG +I ID ML+ E
Sbjct: 765 QFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLE 824
Query: 1130 REGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNK 1189
E VD+Y V +LR +R MVQ E QY+ IH A++E G+T V S++ ++M K
Sbjct: 825 AENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKK 884
Query: 1190 LDPQTNSSQIKEEFRTLNMVTPTLRV-EDCSIALLPRNHEKNRCMDILPPD-RCLPFLIT 1247
DP + S ++ EF+ L P+ R I N KNR +++P D +P
Sbjct: 885 RDPPSEPSPLEAEFQRL----PSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHE 940
Query: 1248 ID-------------------GESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLV 1288
++ E S YINA+ + SY +P I Q PL T+ DFW+++
Sbjct: 941 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1000
Query: 1289 LDYHCTSVVMLNDV--DPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNA 1346
+VML ++ ++C QYW E G +G I+V+ D R+F + ++
Sbjct: 1001 FQRKVKVIVMLTELKHGDQEICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1059
Query: 1347 ARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGR-------TV 1399
R R V Q+Q+ W + P + + +I+ V + + N EG +
Sbjct: 1060 KRKDS--RTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1116
Query: 1400 VHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEV 1457
+HC +G ++G FCA+ + E + VD+F VK LR +P MV +QY+F Y+V
Sbjct: 1117 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV 1174
Score = 160 bits (405), Expect = 8e-39
Identities = 94/306 (30%), Positives = 158/306 (51%), Gaps = 38/306 (12%)
Query: 933 KDENRMKNRYGNIIAYDHSRVRL---------------QTIEGDTNSD----YINGNYID 973
++EN+ KNR N+I YD++RV L ++ + D++S+ YIN ++I
Sbjct: 915 QEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM 974
Query: 974 GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK 1033
Y +P IA QGP++ETI DFW+M++ I+M+T L + C +YW + + Y
Sbjct: 975 SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG 1034
Query: 1034 DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1093
DI+V L +T+ + Y +R F + + R + Q+ +T W +P L+ ++ V
Sbjct: 1035 DIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVV 1094
Query: 1094 KSKSPPS----------AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVREL 1143
K K P + PL++HC G+ +TG F + +L+ AE E VVDI+ V+ L
Sbjct: 1095 KQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKAL 1154
Query: 1144 RSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPA--SQVRSLYYDMNKLDPQTNSSQIKE 1201
R R MV T EQY F++D I ++ PA QV+ + +K++ ++K+
Sbjct: 1155 RKARPGMVSTFEQYQFLYDVIA-------STYPAQNGQVKKNNHQEDKIEFDNEVDKVKQ 1207
Query: 1202 EFRTLN 1207
+ +N
Sbjct: 1208 DANCVN 1213
Score = 127 bits (318), Expect = 1e-28
Identities = 89/269 (33%), Positives = 130/269 (48%), Gaps = 13/269 (4%)
Query: 1202 EFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAAL 1260
EF+++ V +++ A P N KNR +DILP D L I+G++ SNYINA+
Sbjct: 606 EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 662
Query: 1261 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWP--ENG 1316
+D +K+P +I Q P TV DFWR++ + T +VM+ + C +YWP E G
Sbjct: 663 IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 722
Query: 1317 VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRS 1376
G + V+ D I + I N G R V QF WP + P
Sbjct: 723 TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHL 780
Query: 1377 FLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKT 1436
LKL R+V+ + ++G VVHC G GR+GT+ I + E L + VDV+ V
Sbjct: 781 LLKLRRRVNAFSNFFSGP---IVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 837
Query: 1437 LRNNKPNMVDLLDQYKFCYEVALEYLNSG 1465
LR + MV + QY ++ +EY G
Sbjct: 838 LRRQRCLMVQVEAQYILIHQALVEYNQFG 866
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
precursor [Homo sapiens]
Length = 1304
Score = 347 bits (889), Expect = 6e-95
Identities = 211/598 (35%), Positives = 309/598 (51%), Gaps = 44/598 (7%)
Query: 896 ADLLQHITQMKCA-EGYGFKEEYESFFEGQSA-PWDSAKKDENRMKNRYGNIIAYDHSRV 953
AD+L + K A EG F E++S S P A+K N+ KNRY +I+ YD++RV
Sbjct: 633 ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRV 692
Query: 954 RLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNL 1013
L I GD S+YIN +YIDG+ P YIA QGP ET+ DFWRM+W + I+MVT
Sbjct: 693 ELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRC 752
Query: 1014 VEVGRVKCCKYWP---DDTEIYKDIKVTLIETELLAEYVIRTF-AVEKRGVHEIREIRQF 1069
E R KC +YWP + T + D+ V + + + +Y+I+ V K+ RE+
Sbjct: 753 EEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHI 812
Query: 1070 HFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAE 1129
FT WPDHGVP LL R+V + S +GP+VVHCSAG GRTG +I ID ML+ E
Sbjct: 813 QFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLE 872
Query: 1130 REGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNK 1189
E VD+Y V +LR +R MVQ E QY+ IH A++E G+T V S++ ++M K
Sbjct: 873 AENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKK 932
Query: 1190 LDPQTNSSQIKEEFRTLNMVTPTLRV-EDCSIALLPRNHEKNRCMDILPPD-RCLPFLIT 1247
DP + S ++ EF+ L P+ R I N KNR +++P D +P
Sbjct: 933 RDPPSEPSPLEAEFQRL----PSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHE 988
Query: 1248 ID-------------------GESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLV 1288
++ E S YINA+ + SY +P I Q PL T+ DFW+++
Sbjct: 989 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1048
Query: 1289 LDYHCTSVVMLNDV--DPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNA 1346
+VML ++ ++C QYW E G +G I+V+ D R+F + ++
Sbjct: 1049 FQRKVKVIVMLTELKHGDQEICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1107
Query: 1347 ARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGR-------TV 1399
R R V Q+Q+ W + P + + +I+ V + + N EG +
Sbjct: 1108 KRKDS--RTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1164
Query: 1400 VHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEV 1457
+HC +G ++G FCA+ + E + VD+F VK LR +P MV +QY+F Y+V
Sbjct: 1165 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV 1222
Score = 160 bits (405), Expect = 8e-39
Identities = 94/306 (30%), Positives = 158/306 (51%), Gaps = 38/306 (12%)
Query: 933 KDENRMKNRYGNIIAYDHSRVRL---------------QTIEGDTNSD----YINGNYID 973
++EN+ KNR N+I YD++RV L ++ + D++S+ YIN ++I
Sbjct: 963 QEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM 1022
Query: 974 GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK 1033
Y +P IA QGP++ETI DFW+M++ I+M+T L + C +YW + + Y
Sbjct: 1023 SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG 1082
Query: 1034 DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1093
DI+V L +T+ + Y +R F + + R + Q+ +T W +P L+ ++ V
Sbjct: 1083 DIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVV 1142
Query: 1094 KSKSPPS----------AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVREL 1143
K K P + PL++HC G+ +TG F + +L+ AE E VVDI+ V+ L
Sbjct: 1143 KQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKAL 1202
Query: 1144 RSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPA--SQVRSLYYDMNKLDPQTNSSQIKE 1201
R R MV T EQY F++D I ++ PA QV+ + +K++ ++K+
Sbjct: 1203 RKARPGMVSTFEQYQFLYDVIA-------STYPAQNGQVKKNNHQEDKIEFDNEVDKVKQ 1255
Query: 1202 EFRTLN 1207
+ +N
Sbjct: 1256 DANCVN 1261
Score = 127 bits (318), Expect = 1e-28
Identities = 89/269 (33%), Positives = 130/269 (48%), Gaps = 13/269 (4%)
Query: 1202 EFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAAL 1260
EF+++ V +++ A P N KNR +DILP D L I+G++ SNYINA+
Sbjct: 654 EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 710
Query: 1261 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWP--ENG 1316
+D +K+P +I Q P TV DFWR++ + T +VM+ + C +YWP E G
Sbjct: 711 IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 770
Query: 1317 VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRS 1376
G + V+ D I + I N G R V QF WP + P
Sbjct: 771 TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHL 828
Query: 1377 FLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKT 1436
LKL R+V+ + ++G VVHC G GR+GT+ I + E L + VDV+ V
Sbjct: 829 LLKLRRRVNAFSNFFSGP---IVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 885
Query: 1437 LRNNKPNMVDLLDQYKFCYEVALEYLNSG 1465
LR + MV + QY ++ +EY G
Sbjct: 886 LRRQRCLMVQVEAQYILIHQALVEYNQFG 914
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
precursor [Homo sapiens]
Length = 1143
Score = 347 bits (889), Expect = 6e-95
Identities = 211/598 (35%), Positives = 309/598 (51%), Gaps = 44/598 (7%)
Query: 896 ADLLQHITQMKCA-EGYGFKEEYESFFEGQSA-PWDSAKKDENRMKNRYGNIIAYDHSRV 953
AD+L + K A EG F E++S S P A+K N+ KNRY +I+ YD++RV
Sbjct: 472 ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRV 531
Query: 954 RLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNL 1013
L I GD S+YIN +YIDG+ P YIA QGP ET+ DFWRM+W + I+MVT
Sbjct: 532 ELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRC 591
Query: 1014 VEVGRVKCCKYWP---DDTEIYKDIKVTLIETELLAEYVIRTF-AVEKRGVHEIREIRQF 1069
E R KC +YWP + T + D+ V + + + +Y+I+ V K+ RE+
Sbjct: 592 EEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHI 651
Query: 1070 HFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAE 1129
FT WPDHGVP LL R+V + S +GP+VVHCSAG GRTG +I ID ML+ E
Sbjct: 652 QFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLE 711
Query: 1130 REGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNK 1189
E VD+Y V +LR +R MVQ E QY+ IH A++E G+T V S++ ++M K
Sbjct: 712 AENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKK 771
Query: 1190 LDPQTNSSQIKEEFRTLNMVTPTLRV-EDCSIALLPRNHEKNRCMDILPPD-RCLPFLIT 1247
DP + S ++ EF+ L P+ R I N KNR +++P D +P
Sbjct: 772 RDPPSEPSPLEAEFQRL----PSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHE 827
Query: 1248 ID-------------------GESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLV 1288
++ E S YINA+ + SY +P I Q PL T+ DFW+++
Sbjct: 828 LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 887
Query: 1289 LDYHCTSVVMLNDV--DPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNA 1346
+VML ++ ++C QYW E G +G I+V+ D R+F + ++
Sbjct: 888 FQRKVKVIVMLTELKHGDQEICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 946
Query: 1347 ARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGR-------TV 1399
R R V Q+Q+ W + P + + +I+ V + + N EG +
Sbjct: 947 KRKDS--RTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1003
Query: 1400 VHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEV 1457
+HC +G ++G FCA+ + E + VD+F VK LR +P MV +QY+F Y+V
Sbjct: 1004 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV 1061
Score = 160 bits (405), Expect = 8e-39
Identities = 94/306 (30%), Positives = 158/306 (51%), Gaps = 38/306 (12%)
Query: 933 KDENRMKNRYGNIIAYDHSRVRL---------------QTIEGDTNSD----YINGNYID 973
++EN+ KNR N+I YD++RV L ++ + D++S+ YIN ++I
Sbjct: 802 QEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM 861
Query: 974 GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK 1033
Y +P IA QGP++ETI DFW+M++ I+M+T L + C +YW + + Y
Sbjct: 862 SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG 921
Query: 1034 DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1093
DI+V L +T+ + Y +R F + + R + Q+ +T W +P L+ ++ V
Sbjct: 922 DIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVV 981
Query: 1094 KSKSPPS----------AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVREL 1143
K K P + PL++HC G+ +TG F + +L+ AE E VVDI+ V+ L
Sbjct: 982 KQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKAL 1041
Query: 1144 RSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPA--SQVRSLYYDMNKLDPQTNSSQIKE 1201
R R MV T EQY F++D I ++ PA QV+ + +K++ ++K+
Sbjct: 1042 RKARPGMVSTFEQYQFLYDVIA-------STYPAQNGQVKKNNHQEDKIEFDNEVDKVKQ 1094
Query: 1202 EFRTLN 1207
+ +N
Sbjct: 1095 DANCVN 1100
Score = 127 bits (318), Expect = 1e-28
Identities = 89/269 (33%), Positives = 130/269 (48%), Gaps = 13/269 (4%)
Query: 1202 EFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAAL 1260
EF+++ V +++ A P N KNR +DILP D L I+G++ SNYINA+
Sbjct: 493 EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 549
Query: 1261 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWP--ENG 1316
+D +K+P +I Q P TV DFWR++ + T +VM+ + C +YWP E G
Sbjct: 550 IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 609
Query: 1317 VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRS 1376
G + V+ D I + I N G R V QF WP + P
Sbjct: 610 TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHL 667
Query: 1377 FLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKT 1436
LKL R+V+ + ++G VVHC G GR+GT+ I + E L + VDV+ V
Sbjct: 668 LLKLRRRVNAFSNFFSGP---IVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 724
Query: 1437 LRNNKPNMVDLLDQYKFCYEVALEYLNSG 1465
LR + MV + QY ++ +EY G
Sbjct: 725 LRRQRCLMVQVEAQYILIHQALVEYNQFG 753
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,934,502
Number of Sequences: 37866
Number of extensions: 2798640
Number of successful extensions: 9708
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 132
Number of HSP's successfully gapped in prelim test: 157
Number of HSP's that attempted gapping in prelim test: 7342
Number of HSP's gapped (non-prelim): 1434
length of query: 1465
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1350
effective length of database: 13,892,928
effective search space: 18755452800
effective search space used: 18755452800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.