Search of human proteins with 157419150

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157419150 protein tyrosine phosphatase, receptor type, M
isoform 2 precursor [Homo sapiens]
         (1452 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157419150 protein tyrosine phosphatase, receptor type, M isof...  2989   0.0  
gi|157419152 protein tyrosine phosphatase, receptor type, M isof...  2979   0.0  
gi|148539860 protein tyrosine phosphatase, receptor type, T isof...  1968   0.0  
gi|148539858 protein tyrosine phosphatase, receptor type, T isof...  1956   0.0  
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo...  1853   0.0  
gi|208431815 protein tyrosine phosphatase, receptor type, K isof...  1846   0.0  
gi|110735404 protein tyrosine phosphatase, receptor type, U isof...  1588   0.0  
gi|110735402 protein tyrosine phosphatase, receptor type, U isof...  1582   0.0  
gi|110735406 protein tyrosine phosphatase, receptor type, U isof...  1581   0.0  
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...   513   e-145
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...   505   e-142
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...   498   e-140
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...   498   e-140
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...   498   e-140
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...   498   e-140
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...   498   e-140
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...   498   e-140
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...   498   e-140
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...   496   e-140
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...   496   e-140
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo...   440   e-123
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor...   440   e-123
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo...   440   e-123
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor...   423   e-118
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo...   423   e-118
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p...   377   e-104
gi|194097398 protein tyrosine phosphatase, receptor type, G prec...   368   e-101
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo...   347   6e-95
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo...   347   6e-95
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo...   347   6e-95

>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
            precursor [Homo sapiens]
          Length = 1452

 Score = 2989 bits (7748), Expect = 0.0
 Identities = 1452/1452 (100%), Positives = 1452/1452 (100%)

Query: 1    MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD 60
            MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD
Sbjct: 1    MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD 60

Query: 61   PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV 120
            PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV
Sbjct: 61   PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV 120

Query: 121  NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH 180
            NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH
Sbjct: 121  NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH 180

Query: 181  PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR 240
            PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR
Sbjct: 181  PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR 240

Query: 241  FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI 300
            FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI
Sbjct: 241  FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI 300

Query: 301  QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE 360
            QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE
Sbjct: 301  QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE 360

Query: 361  GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC 420
            GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC
Sbjct: 361  GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC 420

Query: 421  YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED 480
            YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED
Sbjct: 421  YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED 480

Query: 481  LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS 540
            LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS
Sbjct: 481  LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS 540

Query: 541  KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT 600
            KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT
Sbjct: 541  KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT 600

Query: 601  DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY 660
            DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY
Sbjct: 601  DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY 660

Query: 661  FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA 720
            FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA
Sbjct: 661  FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA 720

Query: 721  TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST 780
            TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST
Sbjct: 721  TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST 780

Query: 781  RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY 840
            RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY
Sbjct: 781  RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY 840

Query: 841  YPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGF 900
            YPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGF
Sbjct: 841  YPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGF 900

Query: 901  KEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYID 960
            KEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYID
Sbjct: 901  KEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYID 960

Query: 961  GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK 1020
            GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK
Sbjct: 961  GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK 1020

Query: 1021 DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1080
            DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV
Sbjct: 1021 DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1080

Query: 1081 KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQT 1140
            KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQT
Sbjct: 1081 KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQT 1140

Query: 1141 EEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTL 1200
            EEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTL
Sbjct: 1141 EEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTL 1200

Query: 1201 RVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVT 1260
            RVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVT
Sbjct: 1201 RVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVT 1260

Query: 1261 QHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLE 1320
            QHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLE
Sbjct: 1261 QHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLE 1320

Query: 1321 EDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNG 1380
            EDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNG
Sbjct: 1321 EDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNG 1380

Query: 1381 GEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF 1440
            GEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF
Sbjct: 1381 GEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF 1440

Query: 1441 CYEVALEYLNSG 1452
            CYEVALEYLNSG
Sbjct: 1441 CYEVALEYLNSG 1452


>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
            precursor [Homo sapiens]
          Length = 1465

 Score = 2979 bits (7724), Expect = 0.0
 Identities = 1452/1465 (99%), Positives = 1452/1465 (99%), Gaps = 13/1465 (0%)

Query: 1    MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD 60
            MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD
Sbjct: 1    MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD 60

Query: 61   PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV 120
            PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV
Sbjct: 61   PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV 120

Query: 121  NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH 180
            NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH
Sbjct: 121  NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH 180

Query: 181  PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR 240
            PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR
Sbjct: 181  PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR 240

Query: 241  FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI 300
            FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI
Sbjct: 241  FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI 300

Query: 301  QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE 360
            QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE
Sbjct: 301  QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE 360

Query: 361  GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC 420
            GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC
Sbjct: 361  GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC 420

Query: 421  YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED 480
            YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED
Sbjct: 421  YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED 480

Query: 481  LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS 540
            LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS
Sbjct: 481  LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS 540

Query: 541  KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT 600
            KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT
Sbjct: 541  KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT 600

Query: 601  DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY 660
            DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY
Sbjct: 601  DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY 660

Query: 661  FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA 720
            FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA
Sbjct: 661  FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA 720

Query: 721  TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST 780
            TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST
Sbjct: 721  TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST 780

Query: 781  RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY 840
            RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY
Sbjct: 781  RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY 840

Query: 841  YP-------------DETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQ 887
            YP             DETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQ
Sbjct: 841  YPDPFVPTAILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQ 900

Query: 888  HITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEG 947
            HITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEG
Sbjct: 901  HITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEG 960

Query: 948  DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVK 1007
            DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVK
Sbjct: 961  DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVK 1020

Query: 1008 CCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVP 1067
            CCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVP
Sbjct: 1021 CCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVP 1080

Query: 1068 YHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCV 1127
            YHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCV
Sbjct: 1081 YHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCV 1140

Query: 1128 RELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIK 1187
            RELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIK
Sbjct: 1141 RELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIK 1200

Query: 1188 EEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAAL 1247
            EEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAAL
Sbjct: 1201 EEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAAL 1260

Query: 1248 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRH 1307
            MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRH
Sbjct: 1261 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRH 1320

Query: 1308 GPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKL 1367
            GPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKL
Sbjct: 1321 GPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKL 1380

Query: 1368 IRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNN 1427
            IRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNN
Sbjct: 1381 IRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNN 1440

Query: 1428 KPNMVDLLDQYKFCYEVALEYLNSG 1452
            KPNMVDLLDQYKFCYEVALEYLNSG
Sbjct: 1441 KPNMVDLLDQYKFCYEVALEYLNSG 1465


>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
            precursor [Homo sapiens]
          Length = 1441

 Score = 1968 bits (5098), Expect = 0.0
 Identities = 945/1447 (65%), Positives = 1147/1447 (79%), Gaps = 42/1447 (2%)

Query: 18   AAGETFSGGCLFDEPYSTCGYSQSEGDD-FNWEQVNTLTKPTSDPWMPSGSFMLVNASGR 76
            A  ++ +GGC FDE YS CGYS + G + F WEQ+NT  KP  D  +P+GSFM+VN+SGR
Sbjct: 23   ARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDQAVPTGSFMMVNSSGR 82

Query: 77   PEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDP 136
              GQ+AHLLLP LKENDTHCIDFHY+ SS+  S PG LNVYVKVN GP GNP+WN+SG  
Sbjct: 83   ASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVV 142

Query: 137  TRTWNRAELAISTFWPNFYQVIFEVIT-SGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVE 195
            T  W +AELAISTFWP+FYQVIFE ++  GH GY+A+DEV+VL HPC + PHFLR+QNVE
Sbjct: 143  TEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVE 202

Query: 196  VNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDA 255
            VN GQ ATFQC A G+    D+LWLQ  + RD  L   +V + RRF A+ +V +T +R  
Sbjct: 203  VNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSV 262

Query: 256  GKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVA 315
             KYRC+IR++GG G+SNYAEL+VKEPP PIAPP+L +VGATYLWI+ NANSI GDGPI+ 
Sbjct: 263  SKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIIL 322

Query: 316  REVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTK 375
            +EVEY T +G+W +   VDS +YK+ HLDPD EYEI VLLTRPGEGGTG PGP L TRTK
Sbjct: 323  KEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTK 382

Query: 376  CADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSW 435
            CADP+ GP+ +E+V++++RQ+T++WEPFGY VTRCHSYNLTV Y Y    Q+   EEV  
Sbjct: 383  CADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVI- 441

Query: 436  DTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTF 495
               +SH  +T+  L P+  + ++L+L NPEGR ES+EL+VQT+ED+PGAVP ESIQG  F
Sbjct: 442  -QTSSH--YTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPF 498

Query: 496  EEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYP 555
            EEKI++QW+ P +T GVITLYEI YKAV S DP  DLS+Q G+V KL NETH LF GLYP
Sbjct: 499  EEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYP 558

Query: 556  GTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRG 615
            GTTYSFTI+ASTAKGFGPP T +  TKISAPSMP Y+ +TPLN+TD T+TVMLKPA SRG
Sbjct: 559  GTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRG 618

Query: 616  APVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQP 675
            APVSVYQ+VV+EER +++++  +I++C+ VP+ ++NAS L+S +YFAAE    +L   QP
Sbjct: 619  APVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQP 678

Query: 676  FTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKP-VPEPE 734
            FT+GDNKTYNGYWN PL P KSY IYFQA S+ANGETKI+CV++ATKGA+T      EPE
Sbjct: 679  FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVEPE 738

Query: 735  KQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKR----------KLAKKRKETMSSTRQEM 784
            KQ D+TVK+AGVIAG+L+F+II LGV+L +K+R          KLAKK+KET S  ++EM
Sbjct: 739  KQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREM 798

Query: 785  TVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDE 844
              + ++   +     +  DE FS   + ++NG +  S    +  T T             
Sbjct: 799  GPVASADKPTTKLSASRNDEGFS-SSSQDVNGFTDGSRGELSQPTLT------------- 844

Query: 845  THTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEY 904
                       +Q+H Y+  +P ++ Y   Q  PAIRVADLLQHITQMK  +GYGFKEEY
Sbjct: 845  -----------IQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEY 893

Query: 905  ESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHR 964
            E+  EGQ+A WD+AK+DENR KNRYGNII+YDHSRVRL  ++GD +SDYIN NYIDGYHR
Sbjct: 894  EALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHR 953

Query: 965  PNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKV 1024
            P HYIATQGPMQET+ DFWRM+W EN+ASI+MVTNLVEVGRVKC +YWPDDTE+Y DIKV
Sbjct: 954  PRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKV 1013

Query: 1025 TLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKS 1084
            TLIETE LAEYVIRTF V+K+G HEIRE+R FHFT WPDHGVP +ATGLLGFVRQVK  +
Sbjct: 1014 TLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLN 1073

Query: 1085 PPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQY 1144
            PP AGP+VVHCSAGAGRTGCFI ID MLDMAE EGVVDI+NCVRELR++RVN+VQTEEQY
Sbjct: 1074 PPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQY 1133

Query: 1145 VFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVED 1204
            VF+HDAILEACLCG+T++P  + RSLYY++++LDPQTNSSQIK+EF+TLN+VTP +R ED
Sbjct: 1134 VFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPED 1193

Query: 1205 CSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPL 1264
            CSI LLPRNH+KNR MD+LP DRCLPFLI++DGESSNYINAALMDS+KQP+AF+VTQHPL
Sbjct: 1194 CSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPL 1253

Query: 1265 PNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDII 1324
            PNTV DFWRLV DY+C+SVVMLN++D AQ C QYWPE     +GPIQVEFVSAD++EDII
Sbjct: 1254 PNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDII 1313

Query: 1325 SRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGR 1384
             RIFRI N ARPQDGYR+VQ  Q++GWP YRDTP SKRS LK++R+++KWQE+Y+G EGR
Sbjct: 1314 HRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGR 1373

Query: 1385 TVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEV 1444
            TVVHCLNGGGRSGTFCAI  VCEM++ Q  +DVFH VKTLRNNK NMV+ L+QYKF YEV
Sbjct: 1374 TVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEV 1433

Query: 1445 ALEYLNS 1451
            ALEYL+S
Sbjct: 1434 ALEYLSS 1440


>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
            precursor [Homo sapiens]
          Length = 1460

 Score = 1956 bits (5068), Expect = 0.0
 Identities = 945/1466 (64%), Positives = 1147/1466 (78%), Gaps = 61/1466 (4%)

Query: 18   AAGETFSGGCLFDEPYSTCGYSQSEGDD-FNWEQVNTLTKPTSDPWMPSGSFMLVNASGR 76
            A  ++ +GGC FDE YS CGYS + G + F WEQ+NT  KP  D  +P+GSFM+VN+SGR
Sbjct: 23   ARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDQAVPTGSFMMVNSSGR 82

Query: 77   PEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDP 136
              GQ+AHLLLP LKENDTHCIDFHY+ SS+  S PG LNVYVKVN GP GNP+WN+SG  
Sbjct: 83   ASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVV 142

Query: 137  TRTWNRAELAISTFWPNFYQVIFEVIT-SGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVE 195
            T  W +AELAISTFWP+FYQVIFE ++  GH GY+A+DEV+VL HPC + PHFLR+QNVE
Sbjct: 143  TEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVE 202

Query: 196  VNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDA 255
            VN GQ ATFQC A G+    D+LWLQ  + RD  L   +V + RRF A+ +V +T +R  
Sbjct: 203  VNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSV 262

Query: 256  GKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVA 315
             KYRC+IR++GG G+SNYAEL+VKEPP PIAPP+L +VGATYLWI+ NANSI GDGPI+ 
Sbjct: 263  SKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIIL 322

Query: 316  REVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTK 375
            +EVEY T +G+W +   VDS +YK+ HLDPD EYEI VLLTRPGEGGTG PGP L TRTK
Sbjct: 323  KEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTK 382

Query: 376  CADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSW 435
            CADP+ GP+ +E+V++++RQ+T++WEPFGY VTRCHSYNLTV Y Y    Q+   EEV  
Sbjct: 383  CADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVI- 441

Query: 436  DTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTF 495
               +SH  +T+  L P+  + ++L+L NPEGR ES+EL+VQT+ED+PGAVP ESIQG  F
Sbjct: 442  -QTSSH--YTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPF 498

Query: 496  EEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYP 555
            EEKI++QW+ P +T GVITLYEI YKAV S DP  DLS+Q G+V KL NETH LF GLYP
Sbjct: 499  EEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYP 558

Query: 556  GTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRG 615
            GTTYSFTI+ASTAKGFGPP T +  TKISAPSMP Y+ +TPLN+TD T+TVMLKPA SRG
Sbjct: 559  GTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRG 618

Query: 616  APVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQP 675
            APVSVYQ+VV+EER +++++  +I++C+ VP+ ++NAS L+S +YFAAE    +L   QP
Sbjct: 619  APVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQP 678

Query: 676  FTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATK------------- 722
            FT+GDNKTYNGYWN PL P KSY IYFQA S+ANGETKI+CV++ATK             
Sbjct: 679  FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKAPMGSAQVTPGTP 738

Query: 723  ------GAATPKP-VPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKR-------- 767
                  GA+T      EPEKQ D+TVK+AGVIAG+L+F+II LGV+L +K+R        
Sbjct: 739  LCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSY 798

Query: 768  --KLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSF 825
              KLAKK+KET S  ++EM  + ++   +     +  DE FS   + ++NG +  S    
Sbjct: 799  YLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFS-SSSQDVNGFTDGSRGEL 857

Query: 826  TMKTNTLSTSVPNSYYPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADL 885
            +  T T                        +Q+H Y+  +P ++ Y   Q  PAIRVADL
Sbjct: 858  SQPTLT------------------------IQTHPYRTCDPVEMSYPRDQFQPAIRVADL 893

Query: 886  LQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTI 945
            LQHITQMK  +GYGFKEEYE+  EGQ+A WD+AK+DENR KNRYGNII+YDHSRVRL  +
Sbjct: 894  LQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVL 953

Query: 946  EGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGR 1005
            +GD +SDYIN NYIDGYHRP HYIATQGPMQET+ DFWRM+W EN+ASI+MVTNLVEVGR
Sbjct: 954  DGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGR 1013

Query: 1006 VKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHG 1065
            VKC +YWPDDTE+Y DIKVTLIETE LAEYVIRTF V+K+G HEIRE+R FHFT WPDHG
Sbjct: 1014 VKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHG 1073

Query: 1066 VPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYN 1125
            VP +ATGLLGFVRQVK  +PP AGP+VVHCSAGAGRTGCFI ID MLDMAE EGVVDI+N
Sbjct: 1074 VPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFN 1133

Query: 1126 CVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQ 1185
            CVRELR++RVN+VQTEEQYVF+HDAILEACLCG+T++P  + RSLYY++++LDPQTNSSQ
Sbjct: 1134 CVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQ 1193

Query: 1186 IKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINA 1245
            IK+EF+TLN+VTP +R EDCSI LLPRNH+KNR MD+LP DRCLPFLI++DGESSNYINA
Sbjct: 1194 IKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINA 1253

Query: 1246 ALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVH 1305
            ALMDS+KQP+AF+VTQHPLPNTV DFWRLV DY+C+SVVMLN++D AQ C QYWPE    
Sbjct: 1254 ALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSG 1313

Query: 1306 RHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFL 1365
             +GPIQVEFVSAD++EDII RIFRI N ARPQDGYR+VQ  Q++GWP YRDTP SKRS L
Sbjct: 1314 CYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLL 1373

Query: 1366 KLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLR 1425
            K++R+++KWQE+Y+G EGRTVVHCLNGGGRSGTFCAI  VCEM++ Q  +DVFH VKTLR
Sbjct: 1374 KVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLR 1433

Query: 1426 NNKPNMVDLLDQYKFCYEVALEYLNS 1451
            NNK NMV+ L+QYKF YEVALEYL+S
Sbjct: 1434 NNKSNMVETLEQYKFVYEVALEYLSS 1459


>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
            [Homo sapiens]
          Length = 1440

 Score = 1853 bits (4799), Expect = 0.0
 Identities = 889/1445 (61%), Positives = 1096/1445 (75%), Gaps = 35/1445 (2%)

Query: 14   LLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNA 73
            LL +A G+  +GGC FD+    C Y Q   DDF W  V+        P MP GS+M+V++
Sbjct: 23   LLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDS 82

Query: 74   SGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNIS 133
            S    G++A L LP +KENDTHCIDF Y + S+    PG LN+ V+VN GPL NPIWN++
Sbjct: 83   SDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVT 142

Query: 134  GDPTRTWNRAELAISTFWPNFYQVIFEV-ITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQ 192
            G   R W RAELA+STFWPN YQVIFE  ++ G  GY+AID+++VL +PC ++PHFLR+ 
Sbjct: 143  GFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLG 202

Query: 193  NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
            +VEVNAGQ ATFQC A GR    ++LWLQ  +  D P+ + K  + RRF ASF +   TK
Sbjct: 203  DVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTK 262

Query: 253  RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
             D   YRC+ ++E G G+SN+A+L+V+EPP PIAPPQL  VG TYL IQLNANSI GDGP
Sbjct: 263  TDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGP 322

Query: 313  IVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRT 372
            I+ +EVEY   SGSW +   V++ +YK+ HLDPDTEYEI VLLTRPGEGGTG PGP L T
Sbjct: 323  IILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLIT 382

Query: 373  RTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREE 432
            RTKCA+PMR P+ L++ E+++R+I + WE  GYN+TRCH++N+T+ Y Y  G  E   + 
Sbjct: 383  RTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADC 442

Query: 433  VSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQG 492
            +  D +   PQH + +L PYTNVS+K+IL NPEGRKES+E I+QTDED+PG VP +S+QG
Sbjct: 443  LDMDPKA--PQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQG 500

Query: 493  STFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFG 552
            ++FE KIFL W+EP    G+IT YEI+Y ++ SFDP + ++     VS L N TH +F  
Sbjct: 501  TSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMH 560

Query: 553  LYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYE-LETPLNQTDNTVTVMLKPA 611
            L+PGTTY F IRAST KGFGP      TT ISAP++P YE ++  LN+T  T+TV+L+PA
Sbjct: 561  LHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPA 620

Query: 612  HSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQ 671
             ++GAP+S YQIVVEE  P RTK+    ++CY VP+ +QNA    + YYFAAE P  +L 
Sbjct: 621  QAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLP 680

Query: 672  AAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKP-- 729
               PFT+GDN+TY G+WN PL P K Y IYFQA S    ETK  CV++ATK AAT +P  
Sbjct: 681  EPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEV 740

Query: 730  VPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVN 789
            +P+P KQTD  VKIAG+ AGIL+F+++ L V+L++KK KLAKKRK+ M +TRQEMT MVN
Sbjct: 741  IPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVN 800

Query: 790  SMDKSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDETH 846
            +MD+SYA+Q T   E   + +FMD HN + R                          E H
Sbjct: 801  AMDRSYADQSTLHAEDPLSITFMDQHNFSPRY-------------------------ENH 835

Query: 847  TMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYES 906
            +  +++S L+    Y   E  + PYQTGQLHPAIRVADLLQHI  MK ++ YGFKEEYES
Sbjct: 836  SATAESSRLLDVPRYLC-EGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYES 894

Query: 907  FFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPN 966
            FFEGQSA WD AKKD+NR KNRYGNIIAYDHSRV LQ +E D +SDYIN NYIDGY RP+
Sbjct: 895  FFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPS 954

Query: 967  HYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTL 1026
            HYIATQGP+ ET+YDFWRM+W E +A I+MVTNLVEVGRVKC KYWPDDTE+Y D KVT 
Sbjct: 955  HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTC 1014

Query: 1027 IETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPP 1086
            +E E LAEYV+RTF +E+RG +EIRE++QFHFTGWPDHGVPYHATGLL F+R+VK  +PP
Sbjct: 1015 VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPP 1074

Query: 1087 SAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVF 1146
            SAGP+VVHCSAGAGRTGC+IVIDIMLDMAEREGVVDIYNCV+ LRSRR+NMVQTEEQY+F
Sbjct: 1075 SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIF 1134

Query: 1147 IHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCS 1206
            IHDAILEACLCG+T++P  + ++ Y+DM ++D QTNSS +K+EF+TLN VTP L+ EDCS
Sbjct: 1135 IHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCS 1194

Query: 1207 IALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPN 1266
            IA LPRNH+KNR MD+LPPDRCLPFLITIDGESSNYINAALMDSY+QP+AFIVTQ+PLPN
Sbjct: 1195 IACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPN 1254

Query: 1267 TVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISR 1326
            TVKDFWRLV DY CTS+VMLN+VD +Q CPQYWPE G+ R+GPIQVE +S  ++ D+I+R
Sbjct: 1255 TVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINR 1314

Query: 1327 IFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTV 1386
            IFRI N  RPQ+GY MVQQFQ+LGW  +R+ P SKRSFLKLI QV+KWQEE   GEGRT+
Sbjct: 1315 IFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTI 1374

Query: 1387 VHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVAL 1446
            +HCLNGGGRSG FCAI IV EM++ Q  VDVFHAVKTLRN+KPNMV+  +QY+FCY+VAL
Sbjct: 1375 IHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVAL 1434

Query: 1447 EYLNS 1451
            EYL S
Sbjct: 1435 EYLES 1439


>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
            [Homo sapiens]
          Length = 1446

 Score = 1846 bits (4782), Expect = 0.0
 Identities = 889/1451 (61%), Positives = 1096/1451 (75%), Gaps = 41/1451 (2%)

Query: 14   LLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNA 73
            LL +A G+  +GGC FD+    C Y Q   DDF W  V+        P MP GS+M+V++
Sbjct: 23   LLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDS 82

Query: 74   SGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNIS 133
            S    G++A L LP +KENDTHCIDF Y + S+    PG LN+ V+VN GPL NPIWN++
Sbjct: 83   SDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVT 142

Query: 134  GDPTRTWNRAELAISTFWPNFYQVIFEV-ITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQ 192
            G   R W RAELA+STFWPN YQVIFE  ++ G  GY+AID+++VL +PC ++PHFLR+ 
Sbjct: 143  GFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLG 202

Query: 193  NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
            +VEVNAGQ ATFQC A GR    ++LWLQ  +  D P+ + K  + RRF ASF +   TK
Sbjct: 203  DVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTK 262

Query: 253  RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
             D   YRC+ ++E G G+SN+A+L+V+EPP PIAPPQL  VG TYL IQLNANSI GDGP
Sbjct: 263  TDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGP 322

Query: 313  IVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRT 372
            I+ +EVEY   SGSW +   V++ +YK+ HLDPDTEYEI VLLTRPGEGGTG PGP L T
Sbjct: 323  IILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLIT 382

Query: 373  RTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREE 432
            RTKCA+PMR P+ L++ E+++R+I + WE  GYN+TRCH++N+T+ Y Y  G  E   + 
Sbjct: 383  RTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADC 442

Query: 433  VSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQG 492
            +  D +   PQH + +L PYTNVS+K+IL NPEGRKES+E I+QTDED+PG VP +S+QG
Sbjct: 443  LDMDPKA--PQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQG 500

Query: 493  STFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFG 552
            ++FE KIFL W+EP    G+IT YEI+Y ++ SFDP + ++     VS L N TH +F  
Sbjct: 501  TSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMH 560

Query: 553  LYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYE-LETPLNQTDNTVTVMLKPA 611
            L+PGTTY F IRAST KGFGP      TT ISAP++P YE ++  LN+T  T+TV+L+PA
Sbjct: 561  LHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPA 620

Query: 612  HSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQ 671
             ++GAP+S YQIVVEE  P RTK+    ++CY VP+ +QNA    + YYFAAE P  +L 
Sbjct: 621  QAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLP 680

Query: 672  AAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKP-- 729
               PFT+GDN+TY G+WN PL P K Y IYFQA S    ETK  CV++ATK AAT +P  
Sbjct: 681  EPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEV 740

Query: 730  VPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVN 789
            +P+P KQTD  VKIAG+ AGIL+F+++ L V+L++KK KLAKKRK+ M +TRQEMT MVN
Sbjct: 741  IPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVN 800

Query: 790  SMDKSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDETH 846
            +MD+SYA+Q T   E   + +FMD HN + R                          E H
Sbjct: 801  AMDRSYADQSTLHAEDPLSITFMDQHNFSPRY-------------------------ENH 835

Query: 847  TMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYES 906
            +  +++S L+    Y   E  + PYQTGQLHPAIRVADLLQHI  MK ++ YGFKEEYES
Sbjct: 836  SATAESSRLLDVPRYLC-EGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYES 894

Query: 907  FFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYID------ 960
            FFEGQSA WD AKKD+NR KNRYGNIIAYDHSRV LQ +E D +SDYIN NYID      
Sbjct: 895  FFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRD 954

Query: 961  GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK 1020
            GY RP+HYIATQGP+ ET+YDFWRM+W E +A I+MVTNLVEVGRVKC KYWPDDTE+Y 
Sbjct: 955  GYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYG 1014

Query: 1021 DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1080
            D KVT +E E LAEYV+RTF +E+RG +EIRE++QFHFTGWPDHGVPYHATGLL F+R+V
Sbjct: 1015 DFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRV 1074

Query: 1081 KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQT 1140
            K  +PPSAGP+VVHCSAGAGRTGC+IVIDIMLDMAEREGVVDIYNCV+ LRSRR+NMVQT
Sbjct: 1075 KLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQT 1134

Query: 1141 EEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTL 1200
            EEQY+FIHDAILEACLCG+T++P  + ++ Y+DM ++D QTNSS +K+EF+TLN VTP L
Sbjct: 1135 EEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRL 1194

Query: 1201 RVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVT 1260
            + EDCSIA LPRNH+KNR MD+LPPDRCLPFLITIDGESSNYINAALMDSY+QP+AFIVT
Sbjct: 1195 QAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVT 1254

Query: 1261 QHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLE 1320
            Q+PLPNTVKDFWRLV DY CTS+VMLN+VD +Q CPQYWPE G+ R+GPIQVE +S  ++
Sbjct: 1255 QYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMD 1314

Query: 1321 EDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNG 1380
             D+I+RIFRI N  RPQ+GY MVQQFQ+LGW  +R+ P SKRSFLKLI QV+KWQEE   
Sbjct: 1315 CDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEE 1374

Query: 1381 GEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF 1440
            GEGRT++HCLNGGGRSG FCAI IV EM++ Q  VDVFHAVKTLRN+KPNMV+  +QY+F
Sbjct: 1375 GEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRF 1434

Query: 1441 CYEVALEYLNS 1451
            CY+VALEYL S
Sbjct: 1435 CYDVALEYLES 1445


>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
            precursor [Homo sapiens]
          Length = 1436

 Score = 1588 bits (4111), Expect = 0.0
 Identities = 771/1443 (53%), Positives = 1019/1443 (70%), Gaps = 47/1443 (3%)

Query: 21   ETFSGGCLFDE---PYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRP 77
            ET + GC F+E   P   C YSQ++ DDF WEQV       +   +P GS+++VN S   
Sbjct: 21   ETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHA 80

Query: 78   EGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPT 137
             GQRAH++   L ENDTHC+ F YF+ S+    PG L VYV+VN GPLG+ +WN++G   
Sbjct: 81   PGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHG 140

Query: 138  RTWNRAELAISTFWPNFYQVIFEVITS-GHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEV 196
            R W++AELA+STFWPN YQV+FE + S   +GY+ +D++ +L +PC + PHF R+ +VEV
Sbjct: 141  RQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEV 200

Query: 197  NAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAG 256
            NAGQ A+FQC A GR    +R  LQ       P   ++  S RRF+A+F +   ++ +  
Sbjct: 201  NAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQD 260

Query: 257  KYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAR 316
             YRC+ +   G G+SN+AEL+VKEPP PIAPPQL   G TYL IQLN NSI GDGPIV +
Sbjct: 261  LYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRK 320

Query: 317  EVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKC 376
            E+EY  A G W +   V   +YK+ HLDPDTEYEISVLLTRPG+GGTG PGP L +RTKC
Sbjct: 321  EIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKC 380

Query: 377  ADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGG--QEQVREEVS 434
            A+PMR P+ L   E+++RQ+T++WEP GYNVTRCH+Y +++ Y Y +G    + +RE V 
Sbjct: 381  AEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440

Query: 435  WDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGST 494
              TE    ++TI NL PY NV V+L+L NPEGRKE +E+  QTDED+P  +  ES+  + 
Sbjct: 441  --TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498

Query: 495  FEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLY 554
             E+ IFL+W EP +  G+IT YEI+Y+++ S DP +++      +SKL NET+ +F  L+
Sbjct: 499  LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558

Query: 555  PGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614
            PGTTY F++RA T KGFG  A  + TT ISAPS    ++ +PL +++NT+TV+L+PA  R
Sbjct: 559  PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGR 618

Query: 615  GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQ 674
            GAP+SVYQ++VEEER RR ++      C+PVP+ F+ A      +YF AE  A SL  A 
Sbjct: 619  GAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAM 678

Query: 675  PFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKPVP-EP 733
            PFT+GDN+TY G+WN PL P K+Y IYFQAAS   GET+++C+++A K A      P E 
Sbjct: 679  PFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEV 738

Query: 734  EKQTDHTVKIAGVIAGILLFVIIFLG-VVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMD 792
             ++++    I G+ AG L  +I+ LG ++++++K K     K T+ + RQE T M++++D
Sbjct: 739  SQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATV-NYRQEKTHMMSAVD 797

Query: 793  KSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDETHTMA 849
            +S+ +Q T  ++     SFMDTH  + R                         D+     
Sbjct: 798  RSFTDQSTLQEDERLGLSFMDTHGYSTRG------------------------DQRSGGV 833

Query: 850  SDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFE 909
            ++ SSL+     +       PY TGQLHPA+RVADLLQHI QMK AEGYGFK+EYESFFE
Sbjct: 834  TEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFE 893

Query: 910  GQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYI 969
            G    WD+ KK +    +R   + AYD  RV+L  + GD N+DYIN NYIDGYHR NH+I
Sbjct: 894  G----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFI 949

Query: 970  ATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIET 1029
            ATQGP  E +YDFWRMVW E+ +SI+M+T LVEVGRVKC +YWP+D++ Y DIK+ L++T
Sbjct: 950  ATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKT 1009

Query: 1030 ELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAG 1089
            E LAEYV+RTFA+E+RG     E+RQFHFT WP+HGVPYHATGLL F+R+VK+ +PP AG
Sbjct: 1010 ETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAG 1069

Query: 1090 PLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHD 1149
            P+V+HCSAG GRTGC+IV+D+MLDMAE EGVVDIYNCV+ L SRRVNM+QTEEQY+FIHD
Sbjct: 1070 PIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHD 1129

Query: 1150 AILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIAL 1209
            AILEACLCG+T++P S+ ++ Y +M ++DPQ+NSSQ++EEF+TLN VTP L VE+CSIAL
Sbjct: 1130 AILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIAL 1189

Query: 1210 LPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVK 1269
            LPRN +KNR MD+LPPDRCLPFLI+ DG+S+NYINAAL DSY + +AFIVT HPL +T  
Sbjct: 1190 LPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTP 1249

Query: 1270 DFWRLVLDYHCTSVVMLNDV---DPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISR 1326
            DFWRLV DY CTS+VMLN +   + A  C QYWPE G  ++G ++VEF+S   +ED+++R
Sbjct: 1250 DFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVAR 1309

Query: 1327 IFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTV 1386
            +FR+ N +R Q+G+ +V+ FQFL W  YRDTP SK++FL L+ +VDKWQ E   G+GRT+
Sbjct: 1310 VFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAE--SGDGRTI 1367

Query: 1387 VHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVAL 1446
            VHCLNGGGRSGTFCA + V EM+R    VDVF A KTLRN KPNMV+ +DQY FCY+VAL
Sbjct: 1368 VHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVAL 1427

Query: 1447 EYL 1449
            EYL
Sbjct: 1428 EYL 1430


>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
            precursor [Homo sapiens]
          Length = 1446

 Score = 1582 bits (4096), Expect = 0.0
 Identities = 771/1453 (53%), Positives = 1018/1453 (70%), Gaps = 57/1453 (3%)

Query: 21   ETFSGGCLFDE---PYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRP 77
            ET + GC F+E   P   C YSQ++ DDF WEQV       +   +P GS+++VN S   
Sbjct: 21   ETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHA 80

Query: 78   EGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPT 137
             GQRAH++   L ENDTHC+ F YF+ S+    PG L VYV+VN GPLG+ +WN++G   
Sbjct: 81   PGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHG 140

Query: 138  RTWNRAELAISTFWPNFYQVIFEVITS-GHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEV 196
            R W++AELA+STFWPN YQV+FE + S   +GY+ +D++ +L +PC + PHF R+ +VEV
Sbjct: 141  RQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEV 200

Query: 197  NAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAG 256
            NAGQ A+FQC A GR    +R  LQ       P   ++  S RRF+A+F +   ++ +  
Sbjct: 201  NAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQD 260

Query: 257  KYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAR 316
             YRC+ +   G G+SN+AEL+VKEPP PIAPPQL   G TYL IQLN NSI GDGPIV +
Sbjct: 261  LYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRK 320

Query: 317  EVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKC 376
            E+EY  A G W +   V   +YK+ HLDPDTEYEISVLLTRPG+GGTG PGP L +RTKC
Sbjct: 321  EIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKC 380

Query: 377  ADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGG--QEQVREEVS 434
            A+PMR P+ L   E+++RQ+T++WEP GYNVTRCH+Y +++ Y Y +G    + +RE V 
Sbjct: 381  AEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440

Query: 435  WDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGST 494
              TE    ++TI NL PY NV V+L+L NPEGRKE +E+  QTDED+P  +  ES+  + 
Sbjct: 441  --TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498

Query: 495  FEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLY 554
             E+ IFL+W EP +  G+IT YEI+Y+++ S DP +++      +SKL NET+ +F  L+
Sbjct: 499  LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558

Query: 555  PGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614
            PGTTY F++RA T KGFG  A  + TT ISAPS    ++ +PL +++NT+TV+L+PA  R
Sbjct: 559  PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGR 618

Query: 615  GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQ 674
            GAP+SVYQ++VEEER RR ++      C+PVP+ F+ A      +YF AE  A SL  A 
Sbjct: 619  GAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAM 678

Query: 675  PFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKPVP-EP 733
            PFT+GDN+TY G+WN PL P K+Y IYFQAAS   GET+++C+++A K A      P E 
Sbjct: 679  PFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEV 738

Query: 734  EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKR-----------KLAKKRKETMSSTRQ 782
             ++++    I G+ AG L  +I+ LG ++V+ ++           K     K T+ + RQ
Sbjct: 739  SQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYPKPVNMTKATV-NYRQ 797

Query: 783  EMTVMVNSMDKSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNS 839
            E T M++++D+S+ +Q T  ++     SFMDTH  + R                      
Sbjct: 798  EKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRG--------------------- 836

Query: 840  YYPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYG 899
               D+     ++ SSL+     +       PY TGQLHPA+RVADLLQHI QMK AEGYG
Sbjct: 837  ---DQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYG 893

Query: 900  FKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYI 959
            FK+EYESFFEG    WD+ KK +    +R   + AYD  RV+L  + GD N+DYIN NYI
Sbjct: 894  FKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYI 949

Query: 960  DGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIY 1019
            DGYHR NH+IATQGP  E +YDFWRMVW E+ +SI+M+T LVEVGRVKC +YWP+D++ Y
Sbjct: 950  DGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTY 1009

Query: 1020 KDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQ 1079
             DIK+ L++TE LAEYV+RTFA+E+RG     E+RQFHFT WP+HGVPYHATGLL F+R+
Sbjct: 1010 GDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRR 1069

Query: 1080 VKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQ 1139
            VK+ +PP AGP+V+HCSAG GRTGC+IV+D+MLDMAE EGVVDIYNCV+ L SRRVNM+Q
Sbjct: 1070 VKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQ 1129

Query: 1140 TEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPT 1199
            TEEQY+FIHDAILEACLCG+T++P S+ ++ Y +M ++DPQ+NSSQ++EEF+TLN VTP 
Sbjct: 1130 TEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPP 1189

Query: 1200 LRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIV 1259
            L VE+CSIALLPRN +KNR MD+LPPDRCLPFLI+ DG+S+NYINAAL DSY + +AFIV
Sbjct: 1190 LDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIV 1249

Query: 1260 TQHPLPNTVKDFWRLVLDYHCTSVVMLNDV---DPAQLCPQYWPENGVHRHGPIQVEFVS 1316
            T HPL +T  DFWRLV DY CTS+VMLN +   + A  C QYWPE G  ++G ++VEF+S
Sbjct: 1250 TLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMS 1309

Query: 1317 ADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQE 1376
               +ED+++R+FR+ N +R Q+G+ +V+ FQFL W  YRDTP SK++FL L+ +VDKWQ 
Sbjct: 1310 GTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQA 1369

Query: 1377 EYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLD 1436
            E   G+GRT+VHCLNGGGRSGTFCA + V EM+R    VDVF A KTLRN KPNMV+ +D
Sbjct: 1370 E--SGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMD 1427

Query: 1437 QYKFCYEVALEYL 1449
            QY FCY+VALEYL
Sbjct: 1428 QYHFCYDVALEYL 1440


>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
            precursor [Homo sapiens]
          Length = 1442

 Score = 1581 bits (4094), Expect = 0.0
 Identities = 771/1449 (53%), Positives = 1019/1449 (70%), Gaps = 53/1449 (3%)

Query: 21   ETFSGGCLFDE---PYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRP 77
            ET + GC F+E   P   C YSQ++ DDF WEQV       +   +P GS+++VN S   
Sbjct: 21   ETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHA 80

Query: 78   EGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPT 137
             GQRAH++   L ENDTHC+ F YF+ S+    PG L VYV+VN GPLG+ +WN++G   
Sbjct: 81   PGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHG 140

Query: 138  RTWNRAELAISTFWPNFYQVIFEVITS-GHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEV 196
            R W++AELA+STFWPN YQV+FE + S   +GY+ +D++ +L +PC + PHF R+ +VEV
Sbjct: 141  RQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEV 200

Query: 197  NAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAG 256
            NAGQ A+FQC A GR    +R  LQ       P   ++  S RRF+A+F +   ++ +  
Sbjct: 201  NAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQD 260

Query: 257  KYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAR 316
             YRC+ +   G G+SN+AEL+VKEPP PIAPPQL   G TYL IQLN NSI GDGPIV +
Sbjct: 261  LYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRK 320

Query: 317  EVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKC 376
            E+EY  A G W +   V   +YK+ HLDPDTEYEISVLLTRPG+GGTG PGP L +RTKC
Sbjct: 321  EIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKC 380

Query: 377  ADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGG--QEQVREEVS 434
            A+PMR P+ L   E+++RQ+T++WEP GYNVTRCH+Y +++ Y Y +G    + +RE V 
Sbjct: 381  AEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVK 440

Query: 435  WDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGST 494
              TE    ++TI NL PY NV V+L+L NPEGRKE +E+  QTDED+P  +  ES+  + 
Sbjct: 441  --TEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTP 498

Query: 495  FEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLY 554
             E+ IFL+W EP +  G+IT YEI+Y+++ S DP +++      +SKL NET+ +F  L+
Sbjct: 499  LEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLH 558

Query: 555  PGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614
            PGTTY F++RA T KGFG  A  + TT ISAPS    ++ +PL +++NT+TV+L+PA  R
Sbjct: 559  PGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGR 618

Query: 615  GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQ 674
            GAP+SVYQ++VEEER RR ++      C+PVP+ F+ A      +YF AE  A SL  A 
Sbjct: 619  GAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAM 678

Query: 675  PFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKPVP-EP 733
            PFT+GDN+TY G+WN PL P K+Y IYFQAAS   GET+++C+++A K A      P E 
Sbjct: 679  PFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEV 738

Query: 734  EKQTDHTVKIAGVIAGILLFVIIFLG-VVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMD 792
             ++++    I G+ AG L  +I+ LG ++++++K K     K T+ + RQE T M++++D
Sbjct: 739  SQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGKPVNMTKATV-NYRQEKTHMMSAVD 797

Query: 793  KSYAEQGTNCDE---AFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDETHTMA 849
            +S+ +Q T  ++     SFMDTH  + R                         D+     
Sbjct: 798  RSFTDQSTLQEDERLGLSFMDTHGYSTRG------------------------DQRSGGV 833

Query: 850  SDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFE 909
            ++ SSL+     +       PY TGQLHPA+RVADLLQHI QMK AEGYGFK+EYESFFE
Sbjct: 834  TEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFE 893

Query: 910  GQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYID------GYH 963
            G    WD+ KK +    +R   + AYD  RV+L  + GD N+DYIN NYID      GYH
Sbjct: 894  G----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYH 949

Query: 964  RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIK 1023
            R NH+IATQGP  E +YDFWRMVW E+ +SI+M+T LVEVGRVKC +YWP+D++ Y DIK
Sbjct: 950  RSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIK 1009

Query: 1024 VTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSK 1083
            + L++TE LAEYV+RTFA+E+RG     E+RQFHFT WP+HGVPYHATGLL F+R+VK+ 
Sbjct: 1010 IMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKAS 1069

Query: 1084 SPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQ 1143
            +PP AGP+V+HCSAG GRTGC+IV+D+MLDMAE EGVVDIYNCV+ L SRRVNM+QTEEQ
Sbjct: 1070 TPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQ 1129

Query: 1144 YVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVE 1203
            Y+FIHDAILEACLCG+T++P S+ ++ Y +M ++DPQ+NSSQ++EEF+TLN VTP L VE
Sbjct: 1130 YIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVE 1189

Query: 1204 DCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHP 1263
            +CSIALLPRN +KNR MD+LPPDRCLPFLI+ DG+S+NYINAAL DSY + +AFIVT HP
Sbjct: 1190 ECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHP 1249

Query: 1264 LPNTVKDFWRLVLDYHCTSVVMLNDV---DPAQLCPQYWPENGVHRHGPIQVEFVSADLE 1320
            L +T  DFWRLV DY CTS+VMLN +   + A  C QYWPE G  ++G ++VEF+S   +
Sbjct: 1250 LQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTAD 1309

Query: 1321 EDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNG 1380
            ED+++R+FR+ N +R Q+G+ +V+ FQFL W  YRDTP SK++FL L+ +VDKWQ E   
Sbjct: 1310 EDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAE--S 1367

Query: 1381 GEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF 1440
            G+GRT+VHCLNGGGRSGTFCA + V EM+R    VDVF A KTLRN KPNMV+ +DQY F
Sbjct: 1368 GDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHF 1427

Query: 1441 CYEVALEYL 1449
            CY+VALEYL
Sbjct: 1428 CYDVALEYL 1436


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
            precursor [Homo sapiens]
          Length = 1502

 Score =  513 bits (1322), Expect = e-145
 Identities = 375/1161 (32%), Positives = 545/1161 (46%), Gaps = 161/1161 (13%)

Query: 326  SWNDRQPVDSTSYKIGHLDPDTEYEISVL-LTRPGEGGTGSPGPALRTRTKCADPMRGPR 384
            +W      DS    IG+L P   Y + VL  T  G+G   S    ++  T+   P + P 
Sbjct: 462  NWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSD---IQVITQTGVPGQ-PL 517

Query: 385  KLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQH 444
              +        I + W P         S  +  +      G+    + ++ +   S+   
Sbjct: 518  NFKAEPESETSILLSWTP-------PRSDTIANYELVYKDGEHGEEQRITIEPGTSY--- 567

Query: 445  TITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEK------ 498
             +  L P +    +L   +P+G   S   I         A   +S+    F  K      
Sbjct: 568  RLQGLKPNSLYYFRLAARSPQGLGASTAEI--------SARTMQSMFAKNFHVKAVMKTS 619

Query: 499  IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTT 558
            + L W  P + Y     ++I Y      + E+D           G  T  L   L P  +
Sbjct: 620  VLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEKS 666

Query: 559  YSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHSR 614
            YSF +   T +G          T  +AP +    PA+  +T L   D  +TV L P    
Sbjct: 667  YSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVPA 719

Query: 615  GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS----------------Q 658
               +  Y I++   +  R K     +K +  P   +   LL                  +
Sbjct: 720  NENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVELK 775

Query: 659  YYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQ 718
             Y AA F     +    FT+GD+K Y G+ N  L   + Y ++F  A   + E+K+    
Sbjct: 776  PYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATS 830

Query: 719  VATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKETM 777
              +    +    P+P   TD    +  V+  +L  V II + + +++ K           
Sbjct: 831  PYSDPVVSMDLDPQPI--TDEEEGLIWVVGPVLAVVFIICIVIAILLYK----------- 877

Query: 778  SSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVP 837
                                                      S P     ++++  +S+P
Sbjct: 878  ------------------------------------------SKPDRKRAESDSRKSSIP 895

Query: 838  NSYYPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQL--HPAIRVADLLQHITQMKCA 895
            N+               +   H     E   + +QT  +  HP I + +L  HI ++K  
Sbjct: 896  NN-------------KEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKAN 942

Query: 896  EGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYIN 955
            +   F +EYES   GQ   W+ +  + N+ KNRY N+IAYDHSRV L  IEG   SDY+N
Sbjct: 943  DNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVN 1002

Query: 956  GNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD- 1014
             NYIDGY + N YIATQG + ET  DFWRM+W + +A+++M+T L E  RVKC +YWP  
Sbjct: 1003 ANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSR 1062

Query: 1015 DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLL 1074
             TE +  ++VTL++T  LA Y +RTFA+ K G  E RE+RQF FT WPDHGVP H T  L
Sbjct: 1063 GTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFL 1122

Query: 1075 GFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRR 1134
             F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+  + E  VDIY  V  +R++R
Sbjct: 1123 AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQR 1182

Query: 1135 VNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLN 1194
              MVQTE+QY+FIHDA+LEA  CG+T VPA  + +    + +++   N + ++ EF+ L 
Sbjct: 1183 NYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRL- 1241

Query: 1195 MVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQ 1253
              +          A LP N  KNR ++I+P +     L  I G E S+YINA+ +D Y+Q
Sbjct: 1242 -ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQ 1300

Query: 1254 PSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQ 1311
              A+I TQ PL  T +DFWR++ +++ T VVML  +     + C QYWP     R    Q
Sbjct: 1301 QKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP---AERSARYQ 1357

Query: 1312 VEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQ 1370
               V    E ++   I R +     +DG  R V+QFQF  WP  +  P S   F+  I Q
Sbjct: 1358 YFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQ 1416

Query: 1371 VDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPN 1430
            V K +E++ G +G   VHC  G GR+G F  +SIV E +R++  VD+F  VK LR  +P 
Sbjct: 1417 VHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPA 1475

Query: 1431 MVDLLDQYKFCYEVALEYLNS 1451
            MV   DQY+F Y  ALEYL S
Sbjct: 1476 MVQTEDQYQFSYRAALEYLGS 1496



 Score =  137 bits (344), Expect = 1e-31
 Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)

Query: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271
            N  KNR  +++  D     L  I+G   S+Y+NA  +D Y++ +A+I TQ  LP T  DF
Sbjct: 970  NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1029

Query: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329
            WR++ +    +VVM+  ++      C QYWP  G   HG +QV  +          R F 
Sbjct: 1030 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1089

Query: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389
            +Y     +   R V+QFQF  WP +   P     FL  +R+V           G  VVHC
Sbjct: 1090 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1143

Query: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449
              G GR+G F  I  + E ++H++TVD++  V  +R  +  MV   DQY F ++  LE +
Sbjct: 1144 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1203

Query: 1450 NSG 1452
              G
Sbjct: 1204 TCG 1206



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 94/440 (21%), Positives = 165/440 (37%), Gaps = 69/440 (15%)

Query: 244 SFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLN 303
           +  +  + + D GKY C+     G   S  A L V+E       P   S+  T   I + 
Sbjct: 188 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEI-MP 246

Query: 304 ANSINGDGPIVAREVEYCTASGSW---------NDRQPVDSTSYKIGHLDPDTEYEISVL 354
             S+N     V   + Y      W          D  P+     ++  +     Y    +
Sbjct: 247 GGSVNITCVAVGSPMPYV----KWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAM 302

Query: 355 LTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRW-----EPFGYNVTR 409
            T            A+   T  A P + P    V E  +  IT+ W     EP  Y + +
Sbjct: 303 STL-------GVIEAIAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ 354

Query: 410 CHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-K 468
               N            E++ +E+         ++++  LSPY++   +++ +N  GR  
Sbjct: 355 HKPKN-----------SEELYKEIDGVATT---RYSVAGLSPYSDYEFRVVAVNNIGRGP 400

Query: 469 ESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDP 528
            S+ ++ QT E  P + P +          I +QW+EP +  G I  Y + Y    + DP
Sbjct: 401 PSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDP 456

Query: 529 EIDLSN------QSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581
              ++N         +++ +GN        L P  TYS  + A T+ G GP +++ Q  T
Sbjct: 457 TQHVNNWMKHNVADSQITTIGN--------LVPQKTYSVKVLAFTSIGDGPLSSDIQVIT 508

Query: 582 KISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILK 641
           +   P  P      P ++T    +++L     R   ++ Y++V ++      ++ T    
Sbjct: 509 QTGVPGQPLNFKAEPESET----SILLSWTPPRSDTIANYELVYKDGEHGEEQRIT---- 560

Query: 642 CYPVPIHFQNASLLNSQYYF 661
             P   +       NS YYF
Sbjct: 561 IEPGTSYRLQGLKPNSLYYF 580



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 95/401 (23%), Positives = 155/401 (38%), Gaps = 44/401 (10%)

Query: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
           N E+  G      C A+G  +   +  L   D+   P  ++ +    R +   N V    
Sbjct: 241 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 291

Query: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
           R +  Y C+  +  GV I   A++ VK  P P   P +    AT   I L  +S N + P
Sbjct: 292 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 347

Query: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370
           +    +++   +    + +   V +T Y +  L P ++YE  V+       G G P   +
Sbjct: 348 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 405

Query: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430
            T+T    P   PR ++   + S  I ++W+       +   Y +     Y +   + V 
Sbjct: 406 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 461

Query: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489
             +  +  +S    TI NL P    SVK++     G    S ++ V T   +PG  P   
Sbjct: 462 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 519

Query: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547
                 E  I L W  P      I  YE+ YK             + G   ++  E  T 
Sbjct: 520 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 566

Query: 548 FLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSM 588
           +   GL P + Y F + A + +G G       T +ISA +M
Sbjct: 567 YRLQGLKPNSLYYFRLAARSPQGLGAS-----TAEISARTM 602


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score =  505 bits (1301), Expect = e-142
 Identities = 351/981 (35%), Positives = 492/981 (50%), Gaps = 116/981 (11%)

Query: 499  IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTT 558
            + L W  P   Y   T Y+I Y  ++    ++D           G  T  L   L P T 
Sbjct: 1050 VLLSWEFP-DNYNSPTPYKIQYNGLTL---DVD-----------GRTTKKLITHLKPHTF 1094

Query: 559  YSFTI--RASTAKGFGPPAT--NQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614
            Y+F +  R S+  G     T    F      PS+       P    D  + V L    S 
Sbjct: 1095 YNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQSP 1148

Query: 615  GAPVSVYQIVVEEERPRR---------TKKTTEILKCYPVPIHFQNASLLNSQY------ 659
              PV  Y IV+   R  R         + +  ++ +        Q  SL +S+       
Sbjct: 1149 -VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRP 1207

Query: 660  YFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQV 719
            Y AA F          F  GD K Y G+ N  L P   Y ++  A  + +  T       
Sbjct: 1208 YIAARFSV----LPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT------F 1257

Query: 720  ATKGAATPKPV--PEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKET 776
            A    + P  +  P+P+   D    +  VI  +L  V II + + +++ K K   KRK++
Sbjct: 1258 AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS 1317

Query: 777  MSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSV 836
                                E  T C      ++  +L       P    ++   ++   
Sbjct: 1318 --------------------EPRTKC-----LLNNADLAPHHPKDP----VEMRRINFQT 1348

Query: 837  PNSYYPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAE 896
            P+S                        REP    +++   HP I +AD+ +H  ++K  +
Sbjct: 1349 PDSGLRSPL------------------REPG-FHFESMLSHPPIPIADMAEHTERLKAND 1389

Query: 897  GYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYING 956
                 +EYES   GQ   W+ +  + N+ KNRY N+IAYDHSRV LQ IEG   SDYIN 
Sbjct: 1390 SLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINA 1449

Query: 957  NYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-D 1015
            NY+DGY   N YIATQGP+ ET  DFWRMVW + +A+I+M+T L E  R+KC +YWP+  
Sbjct: 1450 NYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG 1509

Query: 1016 TEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLG 1075
            TE Y  I+VTL++T  LA + +RTF++ K G  E RE+RQF FT WPDHGVP + T  L 
Sbjct: 1510 TETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLA 1569

Query: 1076 FVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRV 1135
            F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+  + E  VD+Y  V  +RS+R 
Sbjct: 1570 FLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRN 1629

Query: 1136 NMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTL-N 1194
             MVQTE+QY FIH+A+LEA  CG+T VPA  + +    + +++P  + + ++ EF+ L N
Sbjct: 1630 YMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLAN 1689

Query: 1195 MVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQ 1253
                T R      A LP N  KNR ++I+P +     L  I G E S+YINA+ +D Y+Q
Sbjct: 1690 SKAHTSRFIS---ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQ 1746

Query: 1254 PSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQ 1311
              A+I TQ PL  T +DFWR++ + + T VVML  +     + C QYWP     R    Q
Sbjct: 1747 QKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP---AERSARYQ 1803

Query: 1312 VEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQ 1370
               V    E ++   I R +     +DG  R V+QFQF  WP  +  P S   F+  I Q
Sbjct: 1804 YFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQ 1862

Query: 1371 VDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPN 1430
            V K +E++ G +G   VHC  G GR+G F  +SIV E +R++  VD+F  VK LR  +P 
Sbjct: 1863 VHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPA 1921

Query: 1431 MVDLLDQYKFCYEVALEYLNS 1451
            MV   D+Y+FCY+ ALEYL S
Sbjct: 1922 MVQTEDEYQFCYQAALEYLGS 1942



 Score =  133 bits (334), Expect = 1e-30
 Identities = 83/243 (34%), Positives = 120/243 (49%), Gaps = 9/243 (3%)

Query: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271
            N  KNR  +++  D     L  I+G   S+YINA  +D Y+  +A+I TQ PLP T  DF
Sbjct: 1416 NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF 1475

Query: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329
            WR+V +    ++VM+  ++      C QYWP  G   +G IQV  +          R F 
Sbjct: 1476 WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFS 1535

Query: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389
            ++     +   R V+QFQF  WP +   P     FL  +R+V           G  VVHC
Sbjct: 1536 LHKNGSSEK--REVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNPP---DAGPIVVHC 1589

Query: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449
              G GR+G F  I  + E ++ ++TVDV+  V  +R+ +  MV   DQY F +E  LE +
Sbjct: 1590 SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1649

Query: 1450 NSG 1452
              G
Sbjct: 1650 GCG 1652



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 100/408 (24%), Positives = 172/408 (42%), Gaps = 44/408 (10%)

Query: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK-R 253
           E+  G      C A+G  +   + W+QG +          +T         NV+  T  +
Sbjct: 255 EIMPGGNVNITCVAVGSPMPYVK-WMQGAE---------DLTPEDDMPVGRNVLELTDVK 304

Query: 254 DAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPI 313
           D+  Y C+  +  GV I   A++ VK  P     P +    AT + I  ++ + +   P+
Sbjct: 305 DSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPD---PV 360

Query: 314 VAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALR 371
               +EY + S  G +  ++ + +T Y IG L P++EYEI V  +     G G P  ++ 
Sbjct: 361 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVV 418

Query: 372 TRTKCADPMRGPRKLEVVEVKSRQITIRW-EPFGYN-VTRCHSYNLTVHYCYQVGGQEQV 429
           TRT    P   PR ++   + +  + ++W EP   N + R +    T+   + VG  ++ 
Sbjct: 419 TRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKH 478

Query: 430 REEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTE 488
             + S  T       T+ +L      +V+++     G    S  + V+T + +PG  P  
Sbjct: 479 NVDDSLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMN 530

Query: 489 SIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHF 548
               +  E  I L W  P Q    I  YE+ ++       E D   + GR       T +
Sbjct: 531 LRAEARSETSITLSWSPPRQE--SIIKYELLFR-------EGDHGREVGRT--FDPTTSY 579

Query: 549 LFFGLYPGTTYSFTIRASTAKGFG--PPATNQFTTKISAPSMPAYELE 594
           +   L P T Y+F + A + +G G   P   Q T + S PS P  +++
Sbjct: 580 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ-SKPSAPPQDVK 626



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 63/248 (25%), Positives = 105/248 (42%), Gaps = 15/248 (6%)

Query: 335 STSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSR 394
           +TSY +  L P+TEY   +    P   G G+  P +R RT  + P   P+ ++ V V+S 
Sbjct: 576 TTSYVVEDLKPNTEYAFRLAARSPQ--GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRST 633

Query: 395 QITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTN 454
            I + W P             +V Y   +G ++   +EV+     +  Q  +  L  +T 
Sbjct: 634 AILVSWRPPPPETHNGALVGYSVRY-RPLGSEDPEPKEVN-GIPPTTTQILLEALEKWTQ 691

Query: 455 VSVKLILMNPEG-RKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYG 511
             +  +     G   ES  ++V+TDED+P A P +    +     I + WR P   + +G
Sbjct: 692 YRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHG 751

Query: 512 VITLYEITYKAVSSFD-------PEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIR 564
            I  Y++ Y  +   +        ++ L++          E   +   L P T YS T+ 
Sbjct: 752 QIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTA-EYEMVITNLQPETAYSITVA 810

Query: 565 ASTAKGFG 572
           A T KG G
Sbjct: 811 AYTMKGDG 818



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 78/326 (23%), Positives = 125/326 (38%), Gaps = 35/326 (10%)

Query: 332 PVDSTSYKIGHLDPDTEYEISVLL-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVE 390
           P  +T   +  L+  T+Y I+ +  T  G G   SP   +  RT    P   PRK+E   
Sbjct: 675 PPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSP---VVVRTDEDVPSAPPRKVEAEA 731

Query: 391 VKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVG----GQEQVRE----EVSWDTENSHP 442
           + +  I + W                VHY    G    G  ++++    +  W+T+++  
Sbjct: 732 LNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAE 791

Query: 443 -QHTITNLSPYT--NVSVKLILMNPEGRKESQELIVQTDEDLPGAV---PTESIQGSTFE 496
            +  ITNL P T  +++V    M  +G +   +++V       GAV   PT S+Q  T E
Sbjct: 792 YEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTK-----GAVLGRPTLSVQ-QTPE 845

Query: 497 EKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPG 556
             +  +W  P    G      + Y+     +    L+      S    E  +   G++ G
Sbjct: 846 GSLLARWEPPA---GTAEDQVLGYRLQFGREDSTPLATLEFPPS----EDRYTASGVHKG 898

Query: 557 TTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVML---KPAHS 613
            TY F + A +  G G  A    +     P      LE   N +  TV +      PA  
Sbjct: 899 ATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAER 958

Query: 614 RGAPVSVYQIVVEEERPRRTKKTTEI 639
            GA V  Y + V E       + TE+
Sbjct: 959 NGAIVK-YTVAVREAGALGPARETEL 983



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 79/341 (23%), Positives = 121/341 (35%), Gaps = 51/341 (14%)

Query: 264  TEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSIN----------GDGPI 313
            TE G G  +   +V  +  VP APP+     A      LNA +I             G I
Sbjct: 700  TEVGPGPESSPVVVRTDEDVPSAPPRKVEAEA------LNATAIRVLWRSPAPGRQHGQI 753

Query: 314  VAREVEYCTASGSWNDRQPV--------------DSTSYK--IGHLDPDTEYEISVLL-T 356
               +V Y    G+     P               D+  Y+  I +L P+T Y I+V   T
Sbjct: 754  RGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYT 813

Query: 357  RPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEP-FGYNVTRCHSYNL 415
              G+G    P   +   TK A  + G   L V +     +  RWEP  G    +   Y L
Sbjct: 814  MKGDGARSKPKVVV---TKGA--VLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRL 868

Query: 416  TVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIV 475
                     G+E      + +   S  ++T + +        +L   +  G  E    ++
Sbjct: 869  QF-------GREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVL 921

Query: 476  QTDEDLPGAVPTE-SIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEIDL 532
               ED P   P      G+     + L+W  P   +  G I  Y +  +   +  P  + 
Sbjct: 922  SIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARE- 980

Query: 533  SNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGP 573
              +    ++ G E      GL P T Y   +RA T +G GP
Sbjct: 981  -TELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGP 1020


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score =  498 bits (1283), Expect = e-140
 Identities = 276/609 (45%), Positives = 373/609 (61%), Gaps = 16/609 (2%)

Query: 851  DTSSLVQSHTYKKREPADVPYQT-GQL-HPAIRVADLLQHITQMKCAEGYGFKEEYESFF 908
            + + L   H     E   + +QT G L HP I +AD+ +H  ++K  +     +EYES  
Sbjct: 899  NNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 958

Query: 909  EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY 968
             GQ   W+ +  + N+ KNRY N+IAYDHSRV LQ IEG   SDYIN NY+DGY   N Y
Sbjct: 959  PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1018

Query: 969  IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLI 1027
            IATQGP+ ET  DFWRMVW + +A+I+M+T L E  R+KC +YWP+  TE Y  I+VTL+
Sbjct: 1019 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1078

Query: 1028 ETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPS 1087
            +T  LA + +RTF++ K G  E RE+RQF FT WPDHGVP + T  L F+R+VK+ +PP 
Sbjct: 1079 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1138

Query: 1088 AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFI 1147
            AGP+VVHCSAG GRTGCFIVID ML+  + E  VD+Y  V  +RS+R  MVQTE+QY FI
Sbjct: 1139 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1198

Query: 1148 HDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTL-NMVTPTLRVEDCS 1206
            H+A+LEA  CG+T VPA  + +    + +++P  + + ++ EF+ L N    T R     
Sbjct: 1199 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS-- 1256

Query: 1207 IALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLP 1265
             A LP N  KNR ++I+P +     L  I G E S+YINA+ +D Y+Q  A+I TQ PL 
Sbjct: 1257 -ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1315

Query: 1266 NTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDI 1323
             T +DFWR++ + + T VVML  +     + C QYWP     R    Q   V    E ++
Sbjct: 1316 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNM 1372

Query: 1324 ISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGE 1382
               I R +     +DG  R V+QFQF  WP  +  P S   F+  I QV K +E++ G +
Sbjct: 1373 PQYILREFKVTDARDGQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQD 1430

Query: 1383 GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCY 1442
            G   VHC  G GR+G F  +SIV E +R++  VD+F  VK LR  +P MV   D+Y+FCY
Sbjct: 1431 GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1490

Query: 1443 EVALEYLNS 1451
            + ALEYL S
Sbjct: 1491 QAALEYLGS 1499



 Score =  133 bits (334), Expect = 1e-30
 Identities = 83/243 (34%), Positives = 120/243 (49%), Gaps = 9/243 (3%)

Query: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271
            N  KNR  +++  D     L  I+G   S+YINA  +D Y+  +A+I TQ PLP T  DF
Sbjct: 973  NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF 1032

Query: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329
            WR+V +    ++VM+  ++      C QYWP  G   +G IQV  +          R F 
Sbjct: 1033 WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFS 1092

Query: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389
            ++     +   R V+QFQF  WP +   P     FL  +R+V           G  VVHC
Sbjct: 1093 LHKNGSSEK--REVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNPP---DAGPIVVHC 1146

Query: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449
              G GR+G F  I  + E ++ ++TVDV+  V  +R+ +  MV   DQY F +E  LE +
Sbjct: 1147 SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1206

Query: 1450 NSG 1452
              G
Sbjct: 1207 GCG 1209



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 97/400 (24%), Positives = 167/400 (41%), Gaps = 43/400 (10%)

Query: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK-R 253
           E+  G      C A+G  +   + W+QG +          +T         NV+  T  +
Sbjct: 246 EIMPGGNVNITCVAVGSPMPYVK-WMQGAE---------DLTPEDDMPVGRNVLELTDVK 295

Query: 254 DAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPI 313
           D+  Y C+  +  GV I   A++ VK  P     P +    AT + I  ++ + +   P+
Sbjct: 296 DSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPD---PV 351

Query: 314 VAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALR 371
               +EY + S  G +  ++ + +T Y IG L P++EYEI V  +     G G P  ++ 
Sbjct: 352 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVV 409

Query: 372 TRTKCADPMRGPRKLEVVEVKSRQITIRW-EPFGYN-VTRCHSYNLTVHYCYQVGGQEQV 429
           TRT    P   PR ++   + +  + ++W EP   N + R +    T+   + VG  ++ 
Sbjct: 410 TRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKH 469

Query: 430 REEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTE 488
             + S  T       T+ +L      +V+++     G    S  + V+T + +PG  P  
Sbjct: 470 NVDDSLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMN 521

Query: 489 SIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHF 548
               +  E  I L W  P Q    I  YE+ ++       E D   + GR       T +
Sbjct: 522 LRAEARSETSITLSWSPPRQE--SIIKYELLFR-------EGDHGREVGRT--FDPTTSY 570

Query: 549 LFFGLYPGTTYSFTIRASTAKGFG--PPATNQFTTKISAP 586
           +   L P T Y+F + A + +G G   P   Q T +  +P
Sbjct: 571 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISP 610



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 111/482 (23%), Positives = 174/482 (36%), Gaps = 75/482 (15%)

Query: 325 GSWNDRQPVDSTSYKIGHLDPDTEYEISVL-LTRPGEGGTGSPGPALRTRTKCADPMRGP 383
           G+W      DS    +G L  D  Y + VL  T  G+G    P   ++ +T+   P + P
Sbjct: 464 GNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDP---IQVKTQQGVPGQ-P 519

Query: 384 RKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVG--GQEQVREEVSWDTENSH 441
             L         IT+ W P      R  S  +     ++ G  G+E  R      T +  
Sbjct: 520 MNLRAEARSETSITLSWSP-----PRQESI-IKYELLFREGDHGREVGR------TFDPT 567

Query: 442 PQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFL 501
             + + +L P T  + +L   +P+G      ++ Q    L    P         +  + L
Sbjct: 568 TSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQ--RTLQSISPKNFKVKMIMKTSVLL 625

Query: 502 QWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSF 561
            W  P   Y   T Y+I Y  ++    ++D           G  T  L   L P T Y+F
Sbjct: 626 SWEFP-DNYNSPTPYKIQYNGLTL---DVD-----------GRTTKKLITHLKPHTFYNF 670

Query: 562 TI--RASTAKGFGPPAT--NQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAP 617
            +  R S+  G     T    F      PS+       P    D  + V L    S   P
Sbjct: 671 VLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQSP-VP 723

Query: 618 VSVYQIVVEEERPRR---------TKKTTEILKCYPVPIHFQNASLLNSQY------YFA 662
           V  Y IV+   R  R         + +  ++ +        Q  SL +S+       Y A
Sbjct: 724 VQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIA 783

Query: 663 AEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATK 722
           A F          F  GD K Y G+ N  L P   Y ++  A  + +  T       A  
Sbjct: 784 ARFSV----LPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT------FAAS 833

Query: 723 GAATPKPV--PEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKETMSS 779
             + P  +  P+P+   D    +  VI  +L  V II + + +++ K K   KRK++   
Sbjct: 834 PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR 893

Query: 780 TR 781
           T+
Sbjct: 894 TK 895


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score =  498 bits (1283), Expect = e-140
 Identities = 276/609 (45%), Positives = 373/609 (61%), Gaps = 16/609 (2%)

Query: 851  DTSSLVQSHTYKKREPADVPYQT-GQL-HPAIRVADLLQHITQMKCAEGYGFKEEYESFF 908
            + + L   H     E   + +QT G L HP I +AD+ +H  ++K  +     +EYES  
Sbjct: 1304 NNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 1363

Query: 909  EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY 968
             GQ   W+ +  + N+ KNRY N+IAYDHSRV LQ IEG   SDYIN NY+DGY   N Y
Sbjct: 1364 PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1423

Query: 969  IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLI 1027
            IATQGP+ ET  DFWRMVW + +A+I+M+T L E  R+KC +YWP+  TE Y  I+VTL+
Sbjct: 1424 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1483

Query: 1028 ETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPS 1087
            +T  LA + +RTF++ K G  E RE+RQF FT WPDHGVP + T  L F+R+VK+ +PP 
Sbjct: 1484 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1543

Query: 1088 AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFI 1147
            AGP+VVHCSAG GRTGCFIVID ML+  + E  VD+Y  V  +RS+R  MVQTE+QY FI
Sbjct: 1544 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1603

Query: 1148 HDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTL-NMVTPTLRVEDCS 1206
            H+A+LEA  CG+T VPA  + +    + +++P  + + ++ EF+ L N    T R     
Sbjct: 1604 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS-- 1661

Query: 1207 IALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLP 1265
             A LP N  KNR ++I+P +     L  I G E S+YINA+ +D Y+Q  A+I TQ PL 
Sbjct: 1662 -ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1720

Query: 1266 NTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDI 1323
             T +DFWR++ + + T VVML  +     + C QYWP     R    Q   V    E ++
Sbjct: 1721 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNM 1777

Query: 1324 ISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGE 1382
               I R +     +DG  R V+QFQF  WP  +  P S   F+  I QV K +E++ G +
Sbjct: 1778 PQYILREFKVTDARDGQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQD 1835

Query: 1383 GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCY 1442
            G   VHC  G GR+G F  +SIV E +R++  VD+F  VK LR  +P MV   D+Y+FCY
Sbjct: 1836 GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1895

Query: 1443 EVALEYLNS 1451
            + ALEYL S
Sbjct: 1896 QAALEYLGS 1904



 Score =  133 bits (334), Expect = 1e-30
 Identities = 83/243 (34%), Positives = 120/243 (49%), Gaps = 9/243 (3%)

Query: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271
            N  KNR  +++  D     L  I+G   S+YINA  +D Y+  +A+I TQ PLP T  DF
Sbjct: 1378 NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF 1437

Query: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329
            WR+V +    ++VM+  ++      C QYWP  G   +G IQV  +          R F 
Sbjct: 1438 WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFS 1497

Query: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389
            ++     +   R V+QFQF  WP +   P     FL  +R+V           G  VVHC
Sbjct: 1498 LHKNGSSEK--REVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNPP---DAGPIVVHC 1551

Query: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449
              G GR+G F  I  + E ++ ++TVDV+  V  +R+ +  MV   DQY F +E  LE +
Sbjct: 1552 SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1611

Query: 1450 NSG 1452
              G
Sbjct: 1612 GCG 1614



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 100/408 (24%), Positives = 172/408 (42%), Gaps = 44/408 (10%)

Query: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK-R 253
           E+  G      C A+G  +   + W+QG +          +T         NV+  T  +
Sbjct: 242 EIMPGGNVNITCVAVGSPMPYVK-WMQGAE---------DLTPEDDMPVGRNVLELTDVK 291

Query: 254 DAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPI 313
           D+  Y C+  +  GV I   A++ VK  P     P +    AT + I  ++ + +   P+
Sbjct: 292 DSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPD---PV 347

Query: 314 VAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALR 371
               +EY + S  G +  ++ + +T Y IG L P++EYEI V  +     G G P  ++ 
Sbjct: 348 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVV 405

Query: 372 TRTKCADPMRGPRKLEVVEVKSRQITIRW-EPFGYN-VTRCHSYNLTVHYCYQVGGQEQV 429
           TRT    P   PR ++   + +  + ++W EP   N + R +    T+   + VG  ++ 
Sbjct: 406 TRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKH 465

Query: 430 REEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTE 488
             + S  T       T+ +L      +V+++     G    S  + V+T + +PG  P  
Sbjct: 466 NVDDSLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMN 517

Query: 489 SIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHF 548
               +  E  I L W  P Q    I  YE+ ++       E D   + GR       T +
Sbjct: 518 LRAEARSETSITLSWSPPRQE--SIIKYELLFR-------EGDHGREVGRT--FDPTTSY 566

Query: 549 LFFGLYPGTTYSFTIRASTAKGFG--PPATNQFTTKISAPSMPAYELE 594
           +   L P T Y+F + A + +G G   P   Q T + S PS P  +++
Sbjct: 567 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ-SKPSAPPQDVK 613



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 64/245 (26%), Positives = 104/245 (42%), Gaps = 18/245 (7%)

Query: 335 STSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSR 394
           +TSY +  L P+TEY   +    P   G G+  P +R RT  + P   P+ ++ V V+S 
Sbjct: 563 TTSYVVEDLKPNTEYAFRLAARSPQ--GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRST 620

Query: 395 QITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTN 454
            I + W P             +V Y   +G ++   +EV+     +  Q  +  L  +T 
Sbjct: 621 AILVSWRPPPPETHNGALVGYSVRY-RPLGSEDPEPKEVN-GIPPTTTQILLEALEKWTQ 678

Query: 455 VSVKLILMNPEG-RKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYG 511
             +  +     G   ES  ++V+TDED+P A P +    +     I + WR P   + +G
Sbjct: 679 YRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHG 738

Query: 512 VITLYEITYKAVSSFD----PEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRAST 567
            I  Y++ Y  +   +    P I       +   L +    +   L P T YS T+ A T
Sbjct: 739 QIRGYQVHYVRMEGAEARGPPRI-------KDVMLADAQEMVITNLQPETAYSITVAAYT 791

Query: 568 AKGFG 572
            KG G
Sbjct: 792 MKGDG 796



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 78/332 (23%), Positives = 119/332 (35%), Gaps = 42/332 (12%)

Query: 264 TEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSIN----------GDGPI 313
           TE G G  +   +V  +  VP APP+     A      LNA +I             G I
Sbjct: 687 TEVGPGPESSPVVVRTDEDVPSAPPRKVEAEA------LNATAIRVLWRSPAPGRQHGQI 740

Query: 314 VAREVEYCTASGSWNDRQP-------VDSTSYKIGHLDPDTEYEISVLL-TRPGEGGTGS 365
              +V Y    G+     P        D+    I +L P+T Y I+V   T  G+G    
Sbjct: 741 RGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSK 800

Query: 366 PGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEP-FGYNVTRCHSYNLTVHYCYQVG 424
           P   +   TK A  + G   L V +     +  RWEP  G    +   Y L         
Sbjct: 801 PKVVV---TKGA--VLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQF------- 848

Query: 425 GQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGA 484
           G+E      + +   S  ++T + +        +L   +  G  E    ++   ED P  
Sbjct: 849 GREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRG 908

Query: 485 VPTE-SIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSK 541
            P      G+     + L+W  P   +  G I  Y +  +   +  P  +   +    ++
Sbjct: 909 HPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARE--TELPAAAE 966

Query: 542 LGNETHFLFFGLYPGTTYSFTIRASTAKGFGP 573
            G E      GL P T Y   +RA T +G GP
Sbjct: 967 PGAENALTLQGLKPDTAYDLQVRAHTRRGPGP 998



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 77/321 (23%), Positives = 121/321 (37%), Gaps = 34/321 (10%)

Query: 332 PVDSTSYKIGHLDPDTEYEISVLL-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVE 390
           P  +T   +  L+  T+Y I+ +  T  G G   SP   +  RT    P   PRK+E   
Sbjct: 662 PPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSP---VVVRTDEDVPSAPPRKVEAEA 718

Query: 391 VKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVG----GQEQVREEVSWDTENSHPQHTI 446
           + +  I + W                VHY    G    G  ++++ +  D +    +  I
Sbjct: 719 LNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQ----EMVI 774

Query: 447 TNLSPYT--NVSVKLILMNPEGRKESQELIVQTDEDLPGAV---PTESIQGSTFEEKIFL 501
           TNL P T  +++V    M  +G +   +++V       GAV   PT S+Q  T E  +  
Sbjct: 775 TNLQPETAYSITVAAYTMKGDGARSKPKVVVTK-----GAVLGRPTLSVQ-QTPEGSLLA 828

Query: 502 QWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSF 561
           +W  P    G      + Y+     +    L+      S    E  +   G++ G TY F
Sbjct: 829 RWEPPA---GTAEDQVLGYRLQFGREDSTPLATLEFPPS----EDRYTASGVHKGATYVF 881

Query: 562 TIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVML---KPAHSRGAPV 618
            + A +  G G  A    +     P      LE   N +  TV +      PA   GA V
Sbjct: 882 RLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIV 941

Query: 619 SVYQIVVEEERPRRTKKTTEI 639
             Y + V E       + TE+
Sbjct: 942 K-YTVAVREAGALGPARETEL 961



 Score = 38.5 bits (88), Expect = 0.048
 Identities = 73/305 (23%), Positives = 111/305 (36%), Gaps = 54/305 (17%)

Query: 499  IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTT 558
            + L W  P   Y   T Y+I Y  ++    ++D           G  T  L   L P T 
Sbjct: 1028 VLLSWEFP-DNYNSPTPYKIQYNGLTL---DVD-----------GRTTKKLITHLKPHTF 1072

Query: 559  YSFTI--RASTAKGFGPPAT--NQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614
            Y+F +  R S+  G     T    F      PS+       P    D  + V L    S 
Sbjct: 1073 YNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQSP 1126

Query: 615  GAPVSVYQIVVEEERPRR---------TKKTTEILKCYPVPIHFQNASLLNSQY------ 659
              PV  Y IV+   R  R         + +  ++ +        Q  SL +S+       
Sbjct: 1127 -VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRP 1185

Query: 660  YFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQV 719
            Y AA F          F  GD K Y G+ N  L P   Y ++  A  + +  T       
Sbjct: 1186 YIAARFSV----LPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT------F 1235

Query: 720  ATKGAATPKPV--PEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKET 776
            A    + P  +  P+P+   D    +  VI  +L  V II + + +++ K K   KRK++
Sbjct: 1236 AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS 1295

Query: 777  MSSTR 781
               T+
Sbjct: 1296 EPRTK 1300


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
            isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score =  498 bits (1283), Expect = e-140
 Identities = 276/609 (45%), Positives = 373/609 (61%), Gaps = 16/609 (2%)

Query: 851  DTSSLVQSHTYKKREPADVPYQT-GQL-HPAIRVADLLQHITQMKCAEGYGFKEEYESFF 908
            + + L   H     E   + +QT G L HP I +AD+ +H  ++K  +     +EYES  
Sbjct: 895  NNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 954

Query: 909  EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY 968
             GQ   W+ +  + N+ KNRY N+IAYDHSRV LQ IEG   SDYIN NY+DGY   N Y
Sbjct: 955  PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1014

Query: 969  IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLI 1027
            IATQGP+ ET  DFWRMVW + +A+I+M+T L E  R+KC +YWP+  TE Y  I+VTL+
Sbjct: 1015 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1074

Query: 1028 ETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPS 1087
            +T  LA + +RTF++ K G  E RE+RQF FT WPDHGVP + T  L F+R+VK+ +PP 
Sbjct: 1075 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1134

Query: 1088 AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFI 1147
            AGP+VVHCSAG GRTGCFIVID ML+  + E  VD+Y  V  +RS+R  MVQTE+QY FI
Sbjct: 1135 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1194

Query: 1148 HDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTL-NMVTPTLRVEDCS 1206
            H+A+LEA  CG+T VPA  + +    + +++P  + + ++ EF+ L N    T R     
Sbjct: 1195 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS-- 1252

Query: 1207 IALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLP 1265
             A LP N  KNR ++I+P +     L  I G E S+YINA+ +D Y+Q  A+I TQ PL 
Sbjct: 1253 -ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1311

Query: 1266 NTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDI 1323
             T +DFWR++ + + T VVML  +     + C QYWP     R    Q   V    E ++
Sbjct: 1312 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNM 1368

Query: 1324 ISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGE 1382
               I R +     +DG  R V+QFQF  WP  +  P S   F+  I QV K +E++ G +
Sbjct: 1369 PQYILREFKVTDARDGQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQD 1426

Query: 1383 GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCY 1442
            G   VHC  G GR+G F  +SIV E +R++  VD+F  VK LR  +P MV   D+Y+FCY
Sbjct: 1427 GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1486

Query: 1443 EVALEYLNS 1451
            + ALEYL S
Sbjct: 1487 QAALEYLGS 1495



 Score =  133 bits (334), Expect = 1e-30
 Identities = 83/243 (34%), Positives = 120/243 (49%), Gaps = 9/243 (3%)

Query: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271
            N  KNR  +++  D     L  I+G   S+YINA  +D Y+  +A+I TQ PLP T  DF
Sbjct: 969  NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF 1028

Query: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329
            WR+V +    ++VM+  ++      C QYWP  G   +G IQV  +          R F 
Sbjct: 1029 WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFS 1088

Query: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389
            ++     +   R V+QFQF  WP +   P     FL  +R+V           G  VVHC
Sbjct: 1089 LHKNGSSEK--REVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNPP---DAGPIVVHC 1142

Query: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449
              G GR+G F  I  + E ++ ++TVDV+  V  +R+ +  MV   DQY F +E  LE +
Sbjct: 1143 SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1202

Query: 1450 NSG 1452
              G
Sbjct: 1203 GCG 1205



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 97/400 (24%), Positives = 167/400 (41%), Gaps = 43/400 (10%)

Query: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK-R 253
           E+  G      C A+G  +   + W+QG +          +T         NV+  T  +
Sbjct: 242 EIMPGGNVNITCVAVGSPMPYVK-WMQGAE---------DLTPEDDMPVGRNVLELTDVK 291

Query: 254 DAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPI 313
           D+  Y C+  +  GV I   A++ VK  P     P +    AT + I  ++ + +   P+
Sbjct: 292 DSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPD---PV 347

Query: 314 VAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALR 371
               +EY + S  G +  ++ + +T Y IG L P++EYEI V  +     G G P  ++ 
Sbjct: 348 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVV 405

Query: 372 TRTKCADPMRGPRKLEVVEVKSRQITIRW-EPFGYN-VTRCHSYNLTVHYCYQVGGQEQV 429
           TRT    P   PR ++   + +  + ++W EP   N + R +    T+   + VG  ++ 
Sbjct: 406 TRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKH 465

Query: 430 REEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTE 488
             + S  T       T+ +L      +V+++     G    S  + V+T + +PG  P  
Sbjct: 466 NVDDSLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMN 517

Query: 489 SIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHF 548
               +  E  I L W  P Q    I  YE+ ++       E D   + GR       T +
Sbjct: 518 LRAEARSETSITLSWSPPRQE--SIIKYELLFR-------EGDHGREVGRT--FDPTTSY 566

Query: 549 LFFGLYPGTTYSFTIRASTAKGFG--PPATNQFTTKISAP 586
           +   L P T Y+F + A + +G G   P   Q T +  +P
Sbjct: 567 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISP 606



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 111/482 (23%), Positives = 174/482 (36%), Gaps = 75/482 (15%)

Query: 325 GSWNDRQPVDSTSYKIGHLDPDTEYEISVL-LTRPGEGGTGSPGPALRTRTKCADPMRGP 383
           G+W      DS    +G L  D  Y + VL  T  G+G    P   ++ +T+   P + P
Sbjct: 460 GNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDP---IQVKTQQGVPGQ-P 515

Query: 384 RKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVG--GQEQVREEVSWDTENSH 441
             L         IT+ W P      R  S  +     ++ G  G+E  R      T +  
Sbjct: 516 MNLRAEARSETSITLSWSP-----PRQESI-IKYELLFREGDHGREVGR------TFDPT 563

Query: 442 PQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFL 501
             + + +L P T  + +L   +P+G      ++ Q    L    P         +  + L
Sbjct: 564 TSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQ--RTLQSISPKNFKVKMIMKTSVLL 621

Query: 502 QWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSF 561
            W  P   Y   T Y+I Y  ++    ++D           G  T  L   L P T Y+F
Sbjct: 622 SWEFP-DNYNSPTPYKIQYNGLTL---DVD-----------GRTTKKLITHLKPHTFYNF 666

Query: 562 TI--RASTAKGFGPPAT--NQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAP 617
            +  R S+  G     T    F      PS+       P    D  + V L    S   P
Sbjct: 667 VLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQSP-VP 719

Query: 618 VSVYQIVVEEERPRR---------TKKTTEILKCYPVPIHFQNASLLNSQY------YFA 662
           V  Y IV+   R  R         + +  ++ +        Q  SL +S+       Y A
Sbjct: 720 VQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIA 779

Query: 663 AEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATK 722
           A F          F  GD K Y G+ N  L P   Y ++  A  + +  T       A  
Sbjct: 780 ARFSV----LPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT------FAAS 829

Query: 723 GAATPKPV--PEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKETMSS 779
             + P  +  P+P+   D    +  VI  +L  V II + + +++ K K   KRK++   
Sbjct: 830 PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR 889

Query: 780 TR 781
           T+
Sbjct: 890 TK 891


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score =  498 bits (1282), Expect = e-140
 Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)

Query: 877  HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 936
            HP I + +L  HI ++K  +   F +EYES   GQ   W+ +  + N+ KNRY N+IAYD
Sbjct: 1334 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1393

Query: 937  HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 996
            HSRV L  IEG   SDY+N NYIDGY + N YIATQG + ET  DFWRM+W + +A+++M
Sbjct: 1394 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1453

Query: 997  VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1055
            +T L E  RVKC +YWP   TE +  ++VTL++T  LA Y +RTFA+ K G  E RE+RQ
Sbjct: 1454 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1513

Query: 1056 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1115
            F FT WPDHGVP H T  L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+  
Sbjct: 1514 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1573

Query: 1116 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1175
            + E  VDIY  V  +R++R  MVQTE+QY+FIHDA+LEA  CG+T VPA  + +    + 
Sbjct: 1574 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1633

Query: 1176 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1235
            +++   N + ++ EF+ L   +          A LP N  KNR ++I+P +     L  I
Sbjct: 1634 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1691

Query: 1236 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1292
             G E S+YINA+ +D Y+Q  A+I TQ PL  T +DFWR++ +++ T VVML  +     
Sbjct: 1692 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1751

Query: 1293 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1351
            + C QYWP     R    Q   V    E ++   I R +     +DG  R V+QFQF  W
Sbjct: 1752 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1808

Query: 1352 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1411
            P  +  P S   F+  I QV K +E++ G +G   VHC  G GR+G F  +SIV E +R+
Sbjct: 1809 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1866

Query: 1412 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1451
            +  VD+F  VK LR  +P MV   DQY+F Y  ALEYL S
Sbjct: 1867 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1906



 Score =  137 bits (344), Expect = 1e-31
 Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)

Query: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271
            N  KNR  +++  D     L  I+G   S+Y+NA  +D Y++ +A+I TQ  LP T  DF
Sbjct: 1380 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1439

Query: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329
            WR++ +    +VVM+  ++      C QYWP  G   HG +QV  +          R F 
Sbjct: 1440 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1499

Query: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389
            +Y     +   R V+QFQF  WP +   P     FL  +R+V           G  VVHC
Sbjct: 1500 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1553

Query: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449
              G GR+G F  I  + E ++H++TVD++  V  +R  +  MV   DQY F ++  LE +
Sbjct: 1554 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1613

Query: 1450 NSG 1452
              G
Sbjct: 1614 TCG 1616



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 77/349 (22%), Positives = 127/349 (36%), Gaps = 31/349 (8%)

Query: 258 YRCMIRTEGGVGISNYAELVVKEPPVPIAPPQ---LASVGATYLWIQLNANSINGDGPIV 314
           +R   R+  G+G S            P APPQ     S  +T + +      +     I+
Sbjct: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642

Query: 315 AREVEYCTASGSWNDRQ------PVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGP 368
                  TA    +D+       P D+T Y +  L+  TEY I+V  T   + G G    
Sbjct: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPESL 700

Query: 369 ALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQ 428
           ++  RT    P   PRK+EV  V S  + + W     N          VHY     G+ +
Sbjct: 701 SVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPK 760

Query: 429 --------VREEVSWDTENSHPQHTI-TNLSPYTNVSVKLILMNPEGR-KESQELIVQTD 478
                   +  +  W+ +++     I + L P T+ S+ +     +G    S+  +V T 
Sbjct: 761 GQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 820

Query: 479 EDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGR 538
             +PG      +   T      +QW  P  T+G +  Y + +      +P   L      
Sbjct: 821 GAVPGK--PRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGR-KDMEPLTTLEFSE-- 875

Query: 539 VSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPS 587
                 E HF    ++ G +Y F + A    GFG     + +     P+
Sbjct: 876 -----KEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 919



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 102/438 (23%), Positives = 167/438 (38%), Gaps = 41/438 (9%)

Query: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
           N E+  G      C A+G  +   +  L   D+   P  ++ +    R +   N V    
Sbjct: 244 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 294

Query: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
           R +  Y C+  +  GV I   A++ VK  P P   P +    AT   I L  +S N + P
Sbjct: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 350

Query: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370
           +    +++   +    + +   V +T Y +  L P ++YE  V+       G G P   +
Sbjct: 351 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 408

Query: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430
            T+T    P   PR ++   + S  I ++W+       +   Y +     Y +   + V 
Sbjct: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 464

Query: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489
             +  +  +S    TI NL P    SVK++     G    S ++ V T   +PG  P   
Sbjct: 465 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 522

Query: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547
                 E  I L W  P      I  YE+ YK             + G   ++  E  T 
Sbjct: 523 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 569

Query: 548 FLFFGLYPGTTYSFTIRASTAKGFG-PPATNQFTTKISAPSMPAYELE-TPLNQTDNTVT 605
           +   GL P + Y F + A + +G G   A     T  S PS P  ++  T  + T   V+
Sbjct: 570 YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 629

Query: 606 VMLKPAHSRGAPVSVYQI 623
               P   +   ++ Y I
Sbjct: 630 WQPPPVEKQNGIITEYSI 647



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 94/440 (21%), Positives = 165/440 (37%), Gaps = 69/440 (15%)

Query: 244 SFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLN 303
           +  +  + + D GKY C+     G   S  A L V+E       P   S+  T   I + 
Sbjct: 191 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEI-MP 249

Query: 304 ANSINGDGPIVAREVEYCTASGSW---------NDRQPVDSTSYKIGHLDPDTEYEISVL 354
             S+N     V   + Y      W          D  P+     ++  +     Y    +
Sbjct: 250 GGSVNITCVAVGSPMPYV----KWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAM 305

Query: 355 LTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRW-----EPFGYNVTR 409
            T            A+   T  A P + P    V E  +  IT+ W     EP  Y + +
Sbjct: 306 STL-------GVIEAIAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ 357

Query: 410 CHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-K 468
               N            E++ +E+         ++++  LSPY++   +++ +N  GR  
Sbjct: 358 HKPKN-----------SEELYKEIDGVATT---RYSVAGLSPYSDYEFRVVAVNNIGRGP 403

Query: 469 ESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDP 528
            S+ ++ QT E  P + P +          I +QW+EP +  G I  Y + Y    + DP
Sbjct: 404 PSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDP 459

Query: 529 EIDLSN------QSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581
              ++N         +++ +GN        L P  TYS  + A T+ G GP +++ Q  T
Sbjct: 460 TQHVNNWMKHNVADSQITTIGN--------LVPQKTYSVKVLAFTSIGDGPLSSDIQVIT 511

Query: 582 KISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILK 641
           +   P  P      P ++T    +++L     R   ++ Y++V ++      ++ T    
Sbjct: 512 QTGVPGQPLNFKAEPESET----SILLSWTPPRSDTIANYELVYKDGEHGEEQRIT---- 563

Query: 642 CYPVPIHFQNASLLNSQYYF 661
             P   +       NS YYF
Sbjct: 564 IEPGTSYRLQGLKPNSLYYF 583



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 78/351 (22%), Positives = 129/351 (36%), Gaps = 45/351 (12%)

Query: 257  KYRCMI--RTEGGVGISNYAELVVKEPPVPIAPP---QLASVGATYLWIQLNANSINGD- 310
            +YR  +   T+ G G  + + L+     VP  PP   ++ +V +T + +   +   N   
Sbjct: 682  EYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQH 741

Query: 311  GPIVAREVEYCTASGSWNDRQPV--------------DSTSYK--IGHLDPDTEYEISVL 354
            G I   +V Y          QP+              D+T +   I  L P+T Y ++V 
Sbjct: 742  GQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVT 801

Query: 355  L-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSY 413
              T  G+G    P     T       + G  +L +   +     I+W P          Y
Sbjct: 802  AYTTKGDGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGY 856

Query: 414  NLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQEL 473
             L         G++ +    + +        T T++    +   +L   N  G  E    
Sbjct: 857  RLKF-------GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVK 909

Query: 474  IVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEID 531
             +   E++P   P       T    + L W+ P   +  G+IT Y + Y+     D  I 
Sbjct: 910  EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-----DINIP 964

Query: 532  LSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581
            L      +  +  +T     GL P TTY   +RA T+KG GP + + QF T
Sbjct: 965  LLPMEQLI--VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1013



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 78/366 (21%), Positives = 139/366 (37%), Gaps = 64/366 (17%)

Query: 445  TITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTESIQGSTFEEK----- 498
            T+T L P T   VK+     +G    S  +  +T       +P + +    F  K     
Sbjct: 980  TLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVMKT 1032

Query: 499  -IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGT 557
             + L W  P + Y     ++I Y      + E+D           G  T  L   L P  
Sbjct: 1033 SVLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEK 1079

Query: 558  TYSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHS 613
            +YSF +   T +G          T  +AP +    PA+  +T L   D  +TV L P   
Sbjct: 1080 SYSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVP 1132

Query: 614  RGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS---------------- 657
                +  Y I++   +  R K     +K +  P   +   LL                  
Sbjct: 1133 ANENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVEL 1188

Query: 658  QYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCV 717
            + Y AA F     +    FT+GD+K Y G+ N  L   + Y ++F  A   + E+K+   
Sbjct: 1189 KPYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYAT 1243

Query: 718  QVATKGAATPKPVPEP-EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKET 776
               +    +    P+P   + +  + + G +  ++  + I + ++L  +KR  +  RK +
Sbjct: 1244 SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSS 1303

Query: 777  MSSTRQ 782
            + + ++
Sbjct: 1304 IPNNKE 1309


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score =  498 bits (1282), Expect = e-140
 Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)

Query: 877  HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 936
            HP I + +L  HI ++K  +   F +EYES   GQ   W+ +  + N+ KNRY N+IAYD
Sbjct: 1321 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1380

Query: 937  HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 996
            HSRV L  IEG   SDY+N NYIDGY + N YIATQG + ET  DFWRM+W + +A+++M
Sbjct: 1381 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1440

Query: 997  VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1055
            +T L E  RVKC +YWP   TE +  ++VTL++T  LA Y +RTFA+ K G  E RE+RQ
Sbjct: 1441 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1500

Query: 1056 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1115
            F FT WPDHGVP H T  L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+  
Sbjct: 1501 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1560

Query: 1116 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1175
            + E  VDIY  V  +R++R  MVQTE+QY+FIHDA+LEA  CG+T VPA  + +    + 
Sbjct: 1561 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1620

Query: 1176 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1235
            +++   N + ++ EF+ L   +          A LP N  KNR ++I+P +     L  I
Sbjct: 1621 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1678

Query: 1236 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1292
             G E S+YINA+ +D Y+Q  A+I TQ PL  T +DFWR++ +++ T VVML  +     
Sbjct: 1679 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1738

Query: 1293 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1351
            + C QYWP     R    Q   V    E ++   I R +     +DG  R V+QFQF  W
Sbjct: 1739 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1795

Query: 1352 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1411
            P  +  P S   F+  I QV K +E++ G +G   VHC  G GR+G F  +SIV E +R+
Sbjct: 1796 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1853

Query: 1412 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1451
            +  VD+F  VK LR  +P MV   DQY+F Y  ALEYL S
Sbjct: 1854 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1893



 Score =  137 bits (344), Expect = 1e-31
 Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)

Query: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271
            N  KNR  +++  D     L  I+G   S+Y+NA  +D Y++ +A+I TQ  LP T  DF
Sbjct: 1367 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1426

Query: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329
            WR++ +    +VVM+  ++      C QYWP  G   HG +QV  +          R F 
Sbjct: 1427 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1486

Query: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389
            +Y     +   R V+QFQF  WP +   P     FL  +R+V           G  VVHC
Sbjct: 1487 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1540

Query: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449
              G GR+G F  I  + E ++H++TVD++  V  +R  +  MV   DQY F ++  LE +
Sbjct: 1541 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1600

Query: 1450 NSG 1452
              G
Sbjct: 1601 TCG 1603



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 77/349 (22%), Positives = 127/349 (36%), Gaps = 31/349 (8%)

Query: 258 YRCMIRTEGGVGISNYAELVVKEPPVPIAPPQ---LASVGATYLWIQLNANSINGDGPIV 314
           +R   R+  G+G S            P APPQ     S  +T + +      +     I+
Sbjct: 570 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 629

Query: 315 AREVEYCTASGSWNDRQ------PVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGP 368
                  TA    +D+       P D+T Y +  L+  TEY I+V  T   + G G    
Sbjct: 630 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPESL 687

Query: 369 ALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQ 428
           ++  RT    P   PRK+EV  V S  + + W     N          VHY     G+ +
Sbjct: 688 SVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPK 747

Query: 429 --------VREEVSWDTENSHPQHTI-TNLSPYTNVSVKLILMNPEGR-KESQELIVQTD 478
                   +  +  W+ +++     I + L P T+ S+ +     +G    S+  +V T 
Sbjct: 748 GQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 807

Query: 479 EDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGR 538
             +PG      +   T      +QW  P  T+G +  Y + +      +P   L      
Sbjct: 808 GAVPGK--PRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGR-KDMEPLTTLEFSE-- 862

Query: 539 VSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPS 587
                 E HF    ++ G +Y F + A    GFG     + +     P+
Sbjct: 863 -----KEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 906



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 102/438 (23%), Positives = 167/438 (38%), Gaps = 41/438 (9%)

Query: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
           N E+  G      C A+G  +   +  L   D+   P  ++ +    R +   N V    
Sbjct: 231 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 281

Query: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
           R +  Y C+  +  GV I   A++ VK  P P   P +    AT   I L  +S N + P
Sbjct: 282 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 337

Query: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370
           +    +++   +    + +   V +T Y +  L P ++YE  V+       G G P   +
Sbjct: 338 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 395

Query: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430
            T+T    P   PR ++   + S  I ++W+       +   Y +     Y +   + V 
Sbjct: 396 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 451

Query: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489
             +  +  +S    TI NL P    SVK++     G    S ++ V T   +PG  P   
Sbjct: 452 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 509

Query: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547
                 E  I L W  P      I  YE+ YK             + G   ++  E  T 
Sbjct: 510 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 556

Query: 548 FLFFGLYPGTTYSFTIRASTAKGFG-PPATNQFTTKISAPSMPAYELE-TPLNQTDNTVT 605
           +   GL P + Y F + A + +G G   A     T  S PS P  ++  T  + T   V+
Sbjct: 557 YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 616

Query: 606 VMLKPAHSRGAPVSVYQI 623
               P   +   ++ Y I
Sbjct: 617 WQPPPVEKQNGIITEYSI 634



 Score = 65.1 bits (157), Expect = 5e-10
 Identities = 65/287 (22%), Positives = 119/287 (41%), Gaps = 47/287 (16%)

Query: 388 VVEVKSRQITIRW-----EPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHP 442
           V E  +  IT+ W     EP  Y + +    N            E++ +E+         
Sbjct: 318 VTESTATSITLTWDSGNPEPVSYYIIQHKPKN-----------SEELYKEIDGVATT--- 363

Query: 443 QHTITNLSPYTNVSVKLILMNPEGR-KESQELIVQTDEDLPGAVPTESIQGSTFEEKIFL 501
           ++++  LSPY++   +++ +N  GR   S+ ++ QT E  P + P +          I +
Sbjct: 364 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 423

Query: 502 QWREPTQTYGVITLYEITYKAVSSFDPEIDLSN------QSGRVSKLGNETHFLFFGLYP 555
           QW+EP +  G I  Y + Y    + DP   ++N         +++ +GN        L P
Sbjct: 424 QWKEPEEPNGQIQGYRVYY----TMDPTQHVNNWMKHNVADSQITTIGN--------LVP 471

Query: 556 GTTYSFTIRASTAKGFGPPATN-QFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614
             TYS  + A T+ G GP +++ Q  T+   P  P      P ++T    +++L     R
Sbjct: 472 QKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESET----SILLSWTPPR 527

Query: 615 GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYF 661
              ++ Y++V ++      ++ T      P   +       NS YYF
Sbjct: 528 SDTIANYELVYKDGEHGEEQRIT----IEPGTSYRLQGLKPNSLYYF 570



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 78/351 (22%), Positives = 129/351 (36%), Gaps = 45/351 (12%)

Query: 257  KYRCMI--RTEGGVGISNYAELVVKEPPVPIAPP---QLASVGATYLWIQLNANSINGD- 310
            +YR  +   T+ G G  + + L+     VP  PP   ++ +V +T + +   +   N   
Sbjct: 669  EYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQH 728

Query: 311  GPIVAREVEYCTASGSWNDRQPV--------------DSTSYK--IGHLDPDTEYEISVL 354
            G I   +V Y          QP+              D+T +   I  L P+T Y ++V 
Sbjct: 729  GQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVT 788

Query: 355  L-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSY 413
              T  G+G    P     T       + G  +L +   +     I+W P          Y
Sbjct: 789  AYTTKGDGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGY 843

Query: 414  NLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQEL 473
             L         G++ +    + +        T T++    +   +L   N  G  E    
Sbjct: 844  RLKF-------GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVK 896

Query: 474  IVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEID 531
             +   E++P   P       T    + L W+ P   +  G+IT Y + Y+     D  I 
Sbjct: 897  EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-----DINIP 951

Query: 532  LSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581
            L      +  +  +T     GL P TTY   +RA T+KG GP + + QF T
Sbjct: 952  LLPMEQLI--VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1000



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 78/366 (21%), Positives = 139/366 (37%), Gaps = 64/366 (17%)

Query: 445  TITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTESIQGSTFEEK----- 498
            T+T L P T   VK+     +G    S  +  +T       +P + +    F  K     
Sbjct: 967  TLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVMKT 1019

Query: 499  -IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGT 557
             + L W  P + Y     ++I Y      + E+D           G  T  L   L P  
Sbjct: 1020 SVLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEK 1066

Query: 558  TYSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHS 613
            +YSF +   T +G          T  +AP +    PA+  +T L   D  +TV L P   
Sbjct: 1067 SYSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVP 1119

Query: 614  RGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS---------------- 657
                +  Y I++   +  R K     +K +  P   +   LL                  
Sbjct: 1120 ANENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVEL 1175

Query: 658  QYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCV 717
            + Y AA F     +    FT+GD+K Y G+ N  L   + Y ++F  A   + E+K+   
Sbjct: 1176 KPYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYAT 1230

Query: 718  QVATKGAATPKPVPEP-EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKET 776
               +    +    P+P   + +  + + G +  ++  + I + ++L  +KR  +  RK +
Sbjct: 1231 SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSS 1290

Query: 777  MSSTRQ 782
            + + ++
Sbjct: 1291 IPNNKE 1296


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score =  498 bits (1282), Expect = e-140
 Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)

Query: 877  HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 936
            HP I + +L  HI ++K  +   F +EYES   GQ   W+ +  + N+ KNRY N+IAYD
Sbjct: 1325 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1384

Query: 937  HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 996
            HSRV L  IEG   SDY+N NYIDGY + N YIATQG + ET  DFWRM+W + +A+++M
Sbjct: 1385 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1444

Query: 997  VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1055
            +T L E  RVKC +YWP   TE +  ++VTL++T  LA Y +RTFA+ K G  E RE+RQ
Sbjct: 1445 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1504

Query: 1056 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1115
            F FT WPDHGVP H T  L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+  
Sbjct: 1505 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1564

Query: 1116 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1175
            + E  VDIY  V  +R++R  MVQTE+QY+FIHDA+LEA  CG+T VPA  + +    + 
Sbjct: 1565 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1624

Query: 1176 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1235
            +++   N + ++ EF+ L   +          A LP N  KNR ++I+P +     L  I
Sbjct: 1625 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1682

Query: 1236 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1292
             G E S+YINA+ +D Y+Q  A+I TQ PL  T +DFWR++ +++ T VVML  +     
Sbjct: 1683 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1742

Query: 1293 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1351
            + C QYWP     R    Q   V    E ++   I R +     +DG  R V+QFQF  W
Sbjct: 1743 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1799

Query: 1352 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1411
            P  +  P S   F+  I QV K +E++ G +G   VHC  G GR+G F  +SIV E +R+
Sbjct: 1800 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1857

Query: 1412 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1451
            +  VD+F  VK LR  +P MV   DQY+F Y  ALEYL S
Sbjct: 1858 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1897



 Score =  137 bits (344), Expect = 1e-31
 Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)

Query: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271
            N  KNR  +++  D     L  I+G   S+Y+NA  +D Y++ +A+I TQ  LP T  DF
Sbjct: 1371 NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1430

Query: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329
            WR++ +    +VVM+  ++      C QYWP  G   HG +QV  +          R F 
Sbjct: 1431 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1490

Query: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389
            +Y     +   R V+QFQF  WP +   P     FL  +R+V           G  VVHC
Sbjct: 1491 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1544

Query: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449
              G GR+G F  I  + E ++H++TVD++  V  +R  +  MV   DQY F ++  LE +
Sbjct: 1545 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1604

Query: 1450 NSG 1452
              G
Sbjct: 1605 TCG 1607



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 78/344 (22%), Positives = 126/344 (36%), Gaps = 30/344 (8%)

Query: 258 YRCMIRTEGGVGISNYAELVVKEPPVPIAPPQ---LASVGATYLWIQLNANSINGDGPIV 314
           +R   R+  G+G S            P APPQ     S  +T + +      +     I+
Sbjct: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642

Query: 315 AREVEYCTASGSWNDRQ------PVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGP 368
                  TA    +D+       P D+T Y +  L+  TEY I+V  T   + G G    
Sbjct: 643 TEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITV--TAHTDVGPGPESL 700

Query: 369 ALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGG--- 425
           ++  RT    P   PRK+EV  V S  + + W     N          VHY     G   
Sbjct: 701 SVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPK 760

Query: 426 -QEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-KESQELIVQTDEDLPG 483
            Q  +++ +  D ++      I+ L P T+ S+ +     +G    S+  +V T   +PG
Sbjct: 761 GQPMLKDVMLADAQDM----IISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 816

Query: 484 AVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLG 543
                 +   T      +QW  P  T+G +  Y + +      +P   L           
Sbjct: 817 K--PRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGR-KDMEPLTTLEFSE------- 866

Query: 544 NETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPS 587
            E HF    ++ G +Y F + A    GFG     + +     P+
Sbjct: 867 KEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPT 910



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 102/438 (23%), Positives = 167/438 (38%), Gaps = 41/438 (9%)

Query: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
           N E+  G      C A+G  +   +  L   D+   P  ++ +    R +   N V    
Sbjct: 244 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 294

Query: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
           R +  Y C+  +  GV I   A++ VK  P P   P +    AT   I L  +S N + P
Sbjct: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 350

Query: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370
           +    +++   +    + +   V +T Y +  L P ++YE  V+       G G P   +
Sbjct: 351 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 408

Query: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430
            T+T    P   PR ++   + S  I ++W+       +   Y +     Y +   + V 
Sbjct: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 464

Query: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489
             +  +  +S    TI NL P    SVK++     G    S ++ V T   +PG  P   
Sbjct: 465 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 522

Query: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547
                 E  I L W  P      I  YE+ YK             + G   ++  E  T 
Sbjct: 523 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 569

Query: 548 FLFFGLYPGTTYSFTIRASTAKGFG-PPATNQFTTKISAPSMPAYELE-TPLNQTDNTVT 605
           +   GL P + Y F + A + +G G   A     T  S PS P  ++  T  + T   V+
Sbjct: 570 YRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 629

Query: 606 VMLKPAHSRGAPVSVYQI 623
               P   +   ++ Y I
Sbjct: 630 WQPPPVEKQNGIITEYSI 647



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 94/440 (21%), Positives = 165/440 (37%), Gaps = 69/440 (15%)

Query: 244 SFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLN 303
           +  +  + + D GKY C+     G   S  A L V+E       P   S+  T   I + 
Sbjct: 191 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEI-MP 249

Query: 304 ANSINGDGPIVAREVEYCTASGSW---------NDRQPVDSTSYKIGHLDPDTEYEISVL 354
             S+N     V   + Y      W          D  P+     ++  +     Y    +
Sbjct: 250 GGSVNITCVAVGSPMPYV----KWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAM 305

Query: 355 LTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRW-----EPFGYNVTR 409
            T            A+   T  A P + P    V E  +  IT+ W     EP  Y + +
Sbjct: 306 STL-------GVIEAIAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ 357

Query: 410 CHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-K 468
               N            E++ +E+         ++++  LSPY++   +++ +N  GR  
Sbjct: 358 HKPKN-----------SEELYKEIDGVATT---RYSVAGLSPYSDYEFRVVAVNNIGRGP 403

Query: 469 ESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDP 528
            S+ ++ QT E  P + P +          I +QW+EP +  G I  Y + Y    + DP
Sbjct: 404 PSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDP 459

Query: 529 EIDLSN------QSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581
              ++N         +++ +GN        L P  TYS  + A T+ G GP +++ Q  T
Sbjct: 460 TQHVNNWMKHNVADSQITTIGN--------LVPQKTYSVKVLAFTSIGDGPLSSDIQVIT 511

Query: 582 KISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILK 641
           +   P  P      P ++T    +++L     R   ++ Y++V ++      ++ T    
Sbjct: 512 QTGVPGQPLNFKAEPESET----SILLSWTPPRSDTIANYELVYKDGEHGEEQRIT---- 563

Query: 642 CYPVPIHFQNASLLNSQYYF 661
             P   +       NS YYF
Sbjct: 564 IEPGTSYRLQGLKPNSLYYF 583



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 77/342 (22%), Positives = 127/342 (37%), Gaps = 36/342 (10%)

Query: 257  KYRCMI--RTEGGVGISNYAELVVKEPPVPIAPP---QLASVGATYLWIQLNANSINGD- 310
            +YR  +   T+ G G  + + L+     VP  PP   ++ +V +T + +   +   N   
Sbjct: 682  EYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQH 741

Query: 311  GPIVAREVEYCTASGSWNDRQPV-------DSTSYKIGHLDPDTEYEISVLL-TRPGEGG 362
            G I   +V Y          QP+       D+    I  L P+T Y ++V   T  G+G 
Sbjct: 742  GQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGA 801

Query: 363  TGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQ 422
               P     T       + G  +L +   +     I+W P          Y L       
Sbjct: 802  RSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKF----- 851

Query: 423  VGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLP 482
              G++ +    + +        T T++    +   +L   N  G  E     +   E++P
Sbjct: 852  --GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVP 909

Query: 483  GAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS 540
               P       T    + L W+ P   +  G+IT Y + Y+     D  I L      + 
Sbjct: 910  TGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-----DINIPLLPMEQLI- 963

Query: 541  KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581
             +  +T     GL P TTY   +RA T+KG GP + + QF T
Sbjct: 964  -VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1004



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 78/366 (21%), Positives = 139/366 (37%), Gaps = 64/366 (17%)

Query: 445  TITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTESIQGSTFEEK----- 498
            T+T L P T   VK+     +G    S  +  +T       +P + +    F  K     
Sbjct: 971  TLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVMKT 1023

Query: 499  -IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGT 557
             + L W  P + Y     ++I Y      + E+D           G  T  L   L P  
Sbjct: 1024 SVLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEK 1070

Query: 558  TYSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHS 613
            +YSF +   T +G          T  +AP +    PA+  +T L   D  +TV L P   
Sbjct: 1071 SYSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVP 1123

Query: 614  RGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS---------------- 657
                +  Y I++   +  R K     +K +  P   +   LL                  
Sbjct: 1124 ANENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVEL 1179

Query: 658  QYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCV 717
            + Y AA F     +    FT+GD+K Y G+ N  L   + Y ++F  A   + E+K+   
Sbjct: 1180 KPYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYAT 1234

Query: 718  QVATKGAATPKPVPEP-EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKET 776
               +    +    P+P   + +  + + G +  ++  + I + ++L  +KR  +  RK +
Sbjct: 1235 SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSS 1294

Query: 777  MSSTRQ 782
            + + ++
Sbjct: 1295 IPNNKE 1300


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
            precursor [Homo sapiens]
          Length = 1501

 Score =  498 bits (1282), Expect = e-140
 Identities = 266/580 (45%), Positives = 357/580 (61%), Gaps = 12/580 (2%)

Query: 877  HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYD 936
            HP I + +L  HI ++K  +   F +EYES   GQ   W+ +  + N+ KNRY N+IAYD
Sbjct: 923  HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 982

Query: 937  HSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIM 996
            HSRV L  IEG   SDY+N NYIDGY + N YIATQG + ET  DFWRM+W + +A+++M
Sbjct: 983  HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1042

Query: 997  VTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQ 1055
            +T L E  RVKC +YWP   TE +  ++VTL++T  LA Y +RTFA+ K G  E RE+RQ
Sbjct: 1043 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1102

Query: 1056 FHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMA 1115
            F FT WPDHGVP H T  L F+R+VK+ +PP AGP+VVHCSAG GRTGCFIVID ML+  
Sbjct: 1103 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1162

Query: 1116 EREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMN 1175
            + E  VDIY  V  +R++R  MVQTE+QY+FIHDA+LEA  CG+T VPA  + +    + 
Sbjct: 1163 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1222

Query: 1176 KLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITI 1235
            +++   N + ++ EF+ L   +          A LP N  KNR ++I+P +     L  I
Sbjct: 1223 QIETGENVTGMELEFKRL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1280

Query: 1236 DG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP--A 1292
             G E S+YINA+ +D Y+Q  A+I TQ PL  T +DFWR++ +++ T VVML  +     
Sbjct: 1281 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGR 1340

Query: 1293 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGY-RMVQQFQFLGW 1351
            + C QYWP     R    Q   V    E ++   I R +     +DG  R V+QFQF  W
Sbjct: 1341 EKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDW 1397

Query: 1352 PMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH 1411
            P  +  P S   F+  I QV K +E++ G +G   VHC  G GR+G F  +SIV E +R+
Sbjct: 1398 P-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1455

Query: 1412 QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1451
            +  VD+F  VK LR  +P MV   DQY+F Y  ALEYL S
Sbjct: 1456 EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1495



 Score =  137 bits (344), Expect = 1e-31
 Identities = 81/243 (33%), Positives = 120/243 (49%), Gaps = 9/243 (3%)

Query: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271
            N  KNR  +++  D     L  I+G   S+Y+NA  +D Y++ +A+I TQ  LP T  DF
Sbjct: 969  NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1028

Query: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329
            WR++ +    +VVM+  ++      C QYWP  G   HG +QV  +          R F 
Sbjct: 1029 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1088

Query: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389
            +Y     +   R V+QFQF  WP +   P     FL  +R+V           G  VVHC
Sbjct: 1089 LYKNGSSEK--REVRQFQFTAWPDH-GVPEHPTPFLAFLRRVKTCNPP---DAGPMVVHC 1142

Query: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449
              G GR+G F  I  + E ++H++TVD++  V  +R  +  MV   DQY F ++  LE +
Sbjct: 1143 SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAV 1202

Query: 1450 NSG 1452
              G
Sbjct: 1203 TCG 1205



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 94/440 (21%), Positives = 165/440 (37%), Gaps = 69/440 (15%)

Query: 244 SFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLN 303
           +  +  + + D GKY C+     G   S  A L V+E       P   S+  T   I + 
Sbjct: 191 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEI-MP 249

Query: 304 ANSINGDGPIVAREVEYCTASGSW---------NDRQPVDSTSYKIGHLDPDTEYEISVL 354
             S+N     V   + Y      W          D  P+     ++  +     Y    +
Sbjct: 250 GGSVNITCVAVGSPMPYV----KWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAM 305

Query: 355 LTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRW-----EPFGYNVTR 409
            T            A+   T  A P + P    V E  +  IT+ W     EP  Y + +
Sbjct: 306 STL-------GVIEAIAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ 357

Query: 410 CHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGR-K 468
               N            E++ +E+         ++++  LSPY++   +++ +N  GR  
Sbjct: 358 HKPKN-----------SEELYKEIDGVATT---RYSVAGLSPYSDYEFRVVAVNNIGRGP 403

Query: 469 ESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDP 528
            S+ ++ QT E  P + P +          I +QW+EP +  G I  Y + Y    + DP
Sbjct: 404 PSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY----TMDP 459

Query: 529 EIDLSN------QSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATN-QFTT 581
              ++N         +++ +GN        L P  TYS  + A T+ G GP +++ Q  T
Sbjct: 460 TQHVNNWMKHNVADSQITTIGN--------LVPQKTYSVKVLAFTSIGDGPLSSDIQVIT 511

Query: 582 KISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILK 641
           +   P  P      P ++T    +++L     R   ++ Y++V ++      ++ T    
Sbjct: 512 QTGVPGQPLNFKAEPESET----SILLSWTPPRSDTIANYELVYKDGEHGEEQRIT---- 563

Query: 642 CYPVPIHFQNASLLNSQYYF 661
             P   +       NS YYF
Sbjct: 564 IEPGTSYRLQGLKPNSLYYF 583



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 95/401 (23%), Positives = 155/401 (38%), Gaps = 44/401 (10%)

Query: 193 NVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK 252
           N E+  G      C A+G  +   +  L   D+   P  ++ +    R +   N V    
Sbjct: 244 NHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL--TPEDDMPIG---RNVLELNDV---- 294

Query: 253 RDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP 312
           R +  Y C+  +  GV I   A++ VK  P P   P +    AT   I L  +S N + P
Sbjct: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATS--ITLTWDSGNPE-P 350

Query: 313 IVAREVEYCTASGS--WNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPAL 370
           +    +++   +    + +   V +T Y +  L P ++YE  V+       G G P   +
Sbjct: 351 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEPV 408

Query: 371 RTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVR 430
            T+T    P   PR ++   + S  I ++W+       +   Y +     Y +   + V 
Sbjct: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV----YYTMDPTQHVN 464

Query: 431 EEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTES 489
             +  +  +S    TI NL P    SVK++     G    S ++ V T   +PG  P   
Sbjct: 465 NWMKHNVADSQIT-TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ-PLNF 522

Query: 490 IQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNE--TH 547
                 E  I L W  P      I  YE+ YK             + G   ++  E  T 
Sbjct: 523 KAEPESETSILLSWTPPRS--DTIANYELVYK-----------DGEHGEEQRITIEPGTS 569

Query: 548 FLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSM 588
           +   GL P + Y F + A + +G G       T +ISA +M
Sbjct: 570 YRLQGLKPNSLYYFRLAARSPQGLGAS-----TAEISARTM 605



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 99/485 (20%), Positives = 177/485 (36%), Gaps = 79/485 (16%)

Query: 326 SWNDRQPVDSTSYKIGHLDPDTEYEISVL-LTRPGEGGTGSPGPALRTRTKCADPMRGPR 384
           +W      DS    IG+L P   Y + VL  T  G+G   S    ++  T+   P + P 
Sbjct: 465 NWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSD---IQVITQTGVPGQ-PL 520

Query: 385 KLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQH 444
             +        I + W P         S  +  +      G+    + ++ +   S+   
Sbjct: 521 NFKAEPESETSILLSWTP-------PRSDTIANYELVYKDGEHGEEQRITIEPGTSY--- 570

Query: 445 TITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEK------ 498
            +  L P +    +L   +P+G   S   I         A   +S+    F  K      
Sbjct: 571 RLQGLKPNSLYYFRLAARSPQGLGASTAEI--------SARTMQSMFAKNFHVKAVMKTS 622

Query: 499 IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTT 558
           + L W  P + Y     ++I Y      + E+D           G  T  L   L P  +
Sbjct: 623 VLLSWEIP-ENYNSAMPFKILYDDGKMVE-EVD-----------GRATQKLIVNLKPEKS 669

Query: 559 YSFTIRASTAKGFGPPATNQFTTKISAPSM----PAYELETPLNQTDNTVTVMLKPAHSR 614
           YSF +   T +G          T  +AP +    PA+  +T L   D  +TV L P    
Sbjct: 670 YSFVL---TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL---DGMITVQL-PEVPA 722

Query: 615 GAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNS----------------Q 658
              +  Y I++   +  R K     +K +  P   +   LL                  +
Sbjct: 723 NENIKGYYIIIVPLKKSRGK----FIKPWESPDEMELDELLKEISRKRRSIRYGREVELK 778

Query: 659 YYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQ 718
            Y AA F     +    FT+GD+K Y G+ N  L   + Y ++F  A   + E+K+    
Sbjct: 779 PYIAAHFDVLPTE----FTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKMYATS 833

Query: 719 VATKGAATPKPVPEP-EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETM 777
             +    +    P+P   + +  + + G +  ++  + I + ++L  +KR  +  RK ++
Sbjct: 834 PYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSI 893

Query: 778 SSTRQ 782
            + ++
Sbjct: 894 PNNKE 898


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score =  496 bits (1277), Expect = e-140
 Identities = 271/601 (45%), Positives = 369/601 (61%), Gaps = 14/601 (2%)

Query: 858  SHTYKKREPADVPYQTGQL--HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPW 915
            +H+    E   + YQT  +  HP I + DL  +I ++K  +G  F +EYES   GQ   W
Sbjct: 1308 AHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTW 1367

Query: 916  DSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPM 975
            +++  + N+ KNRY N+IAYDHSRV L +I+G   SDYIN NYIDGY + N YIATQGP+
Sbjct: 1368 ENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPL 1427

Query: 976  QETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAE 1034
             ET+ DFWRMVW + TA+++M+T L E  RVKC +YWP   TE    I+VTL++T  LA 
Sbjct: 1428 PETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELAT 1487

Query: 1035 YVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVH 1094
            Y +RTFA+ K G  E RE+RQF F  WPDHGVP + T +L F+R+VK+ +P  AGP+VVH
Sbjct: 1488 YTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVH 1547

Query: 1095 CSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA 1154
            CSAG GRTGCFIVID ML+  + E  VDIY  V  +RS+R  MVQTE+QYVFIH+A+LEA
Sbjct: 1548 CSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA 1607

Query: 1155 CLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNH 1214
              CG T VPA  + +    + ++ P  + + ++ EF+ L   +          A LP N 
Sbjct: 1608 ATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLL--ASSKAHTSRFISANLPCNK 1665

Query: 1215 EKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWR 1273
             KNR ++I+P +     L  I G E S+YINA+ +D Y+Q  A+I TQ PL  + +DFWR
Sbjct: 1666 FKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWR 1725

Query: 1274 LVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIY 1331
            ++ +++ T +VML  +     + C QYWP     R    Q   V    E ++   I R +
Sbjct: 1726 MLWEHNSTIIVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREF 1782

Query: 1332 NAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCL 1390
                 +DG  R ++QFQF  WP  +  P +   F+  I QV K +E++ G +G   VHC 
Sbjct: 1783 KVTDARDGQSRTIRQFQFTDWP-EQGVPKTGEGFIDFIGQVHKTKEQF-GQDGPITVHCS 1840

Query: 1391 NGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN 1450
             G GR+G F  +SIV E +R++  VD+F  VKTLR  +P MV   DQY+ CY  ALEYL 
Sbjct: 1841 AGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLG 1900

Query: 1451 S 1451
            S
Sbjct: 1901 S 1901



 Score =  137 bits (346), Expect = 6e-32
 Identities = 82/245 (33%), Positives = 126/245 (51%), Gaps = 13/245 (5%)

Query: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271
            N  KNR  +++  D     L +IDG   S+YINA  +D Y++ +A+I TQ PLP T+ DF
Sbjct: 1375 NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDF 1434

Query: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329
            WR+V +    +VVM+  ++      C QYWP  G    G IQV  +          R F 
Sbjct: 1435 WRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFA 1494

Query: 1330 IYNAARPQDGYRMVQQFQFLGWPMYR--DTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVV 1387
            ++ +   +   R ++QFQF+ WP +   + P    +FL+ ++  +          G  VV
Sbjct: 1495 LHKSGSSEK--RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDA------GPMVV 1546

Query: 1388 HCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE 1447
            HC  G GR+G F  I  + E ++H++TVD++  V  +R+ +  MV   DQY F +E  LE
Sbjct: 1547 HCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1606

Query: 1448 YLNSG 1452
                G
Sbjct: 1607 AATCG 1611



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 104/442 (23%), Positives = 175/442 (39%), Gaps = 46/442 (10%)

Query: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRD 254
           EV  G      C A+G  +   + W+ G +      KE ++   R  +   NVV +    
Sbjct: 242 EVMPGGSVNLTCVAVGAPMPYVK-WMMGAEELT---KEDEMPVGRNVLELSNVVRSAN-- 295

Query: 255 AGKYRCMIRTEGGVGISNYAELVVK---EPPVPIAPPQLASVGATYLWIQLNANSINGDG 311
              Y C+  +  G+ I   A++ VK   +PP+ +   +  +   T  W   N+       
Sbjct: 296 ---YTCVAISSLGM-IEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSE------ 345

Query: 312 PIVAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPA 369
           P+    ++Y  A   G + +   V +T Y IG L P +EY   VL       G G P  A
Sbjct: 346 PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN--SIGRGPPSEA 403

Query: 370 LRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQV 429
           +R RT    P   PR+++   + +  + ++WEP          Y   V+Y       +  
Sbjct: 404 VRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYR--VYYT-----PDSR 456

Query: 430 REEVSWDTENSHP--QHTITNLSPYTNVSVKLILMNPEG-RKESQELIVQTDEDLPGAVP 486
           R   +W   N+      T+ +L P    S++++     G    S  + V+T + +P A P
Sbjct: 457 RPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQP 515

Query: 487 TESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNET 546
            +       + +I L W  P Q    I +YE+ Y A    D +  ++            +
Sbjct: 516 ADFQAEVESDTRIQLSWLLPPQER--IIMYELVYWAAEDEDQQHKVT--------FDPTS 565

Query: 547 HFLFFGLYPGTTYSFTIRASTAKGFGP-PATNQFTTKISAPSMPAYELE-TPLNQTDNTV 604
            +    L P T Y F + A +  G G    T +  T  S PS P  ++    +  T   V
Sbjct: 566 SYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRV 625

Query: 605 TVMLKPAHSRGAPVSVYQIVVE 626
           + +  PA SR   ++ Y +  E
Sbjct: 626 SWVPPPADSRNGVITQYSVAYE 647



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 87/366 (23%), Positives = 135/366 (36%), Gaps = 60/366 (16%)

Query: 257  KYRCMIR--TEGGVGISNYAELVVKEPPVPIAPPQLASVG-----ATYLWIQLNANSING 309
            +YR  +R  T+ G G  +   LV  +  VP  PP+   V      A +++ +L   S   
Sbjct: 679  EYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPS-KQ 737

Query: 310  DGPIVAREVEYCT-----------------ASGSWNDRQPVDSTSYK--IGHLDPDTEYE 350
             G I   +V Y                   A   W   +P +S  Y+  I  L P+T Y 
Sbjct: 738  HGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQW---RPEESEDYETTISGLTPETTYS 794

Query: 351  ISVLL-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTR 409
            ++V   T  G+G    P     T       + G   + +         ++W P       
Sbjct: 795  VTVAAYTTKGDGARSKPKIVTTTGA-----VPGRPTMMISTTAMNTALLQWHPPKELPGE 849

Query: 410  CHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE 469
               Y L   YC      E     + +  ++ H   T+T L   T    +L   N  G  E
Sbjct: 850  LLGYRL--QYCR---ADEARPNTIDFGKDDQH--FTVTGLHKGTTYIFRLAAKNRAGLGE 902

Query: 470  SQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFD 527
              E  ++T EDLP   P              L W  P   +  G I  Y + ++ ++S  
Sbjct: 903  EFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS-- 960

Query: 528  PEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPS 587
             + +L N       +  +T F   GL P TTY   +RA T+KG GP      +  I + +
Sbjct: 961  -QQELQN-------ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGP-----LSPSIQSRT 1007

Query: 588  MPAYEL 593
            MP  ++
Sbjct: 1008 MPVEQV 1013



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 88/441 (19%), Positives = 162/441 (36%), Gaps = 97/441 (21%)

Query: 379  PMRGPRKLEVVEVKSRQITIRWEP--FGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWD 436
            P   P+ L V  + +    + W+P        R  SY +       +  Q+++ + ++ D
Sbjct: 915  PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR---DINSQQEL-QNITTD 970

Query: 437  TENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFE 496
            T     + T+T L P T   +K+     +G       I      +           +  +
Sbjct: 971  T-----RFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1025

Query: 497  EKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPG 556
              + L W  P  +Y     ++I Y   S    E+D           G+    L   L P 
Sbjct: 1026 TSVLLSWEVP-DSYKSAVPFKILYNGQSV---EVD-----------GHSMRKLIADLQPN 1070

Query: 557  TTYSFTI--RASTAKGFGP----------------PATNQFTTKISAPSMPA-------- 590
            T YSF +  R S+A G                   PA+          SMP         
Sbjct: 1071 TEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVR 1130

Query: 591  --YELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIV--VEE--ERPRRTKKTTEILKCYP 644
              Y +  P+++   +   ML P  S    + + +++  +E+  E  RR ++  E LK Y 
Sbjct: 1131 WFYIVVVPIDRVGGS---MLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPY- 1186

Query: 645  VPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQA 704
                             AA+         + FT+GD K Y G++N PL P  SY+ +  A
Sbjct: 1187 ----------------VAAQLDV----LPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLA 1226

Query: 705  ASRANGETKIDCVQVATKGAATP-------KPVPEPEKQTDHTVKIAGVIAGILLFVIIF 757
            + +   + K        + A++P       +  P  +++    + + G +  ++L ++I 
Sbjct: 1227 SLKEPMDQK--------RYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIV 1278

Query: 758  LGVVLVMKKRKLAKKRKETMS 778
            + ++L  +KR  +   K+  S
Sbjct: 1279 IAILLFKRKRTHSPSSKDEQS 1299



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 70/300 (23%), Positives = 113/300 (37%), Gaps = 25/300 (8%)

Query: 340 IGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIR 399
           +G L P   Y + VL       G G P P ++ +T+   P + P   +       +I + 
Sbjct: 475 VGSLLPGITYSLRVLAFTAV--GDGPPSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLS 531

Query: 400 WEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKL 459
           W      +       +     Y     E  + +V++D  +S+   T+ +L P T    +L
Sbjct: 532 W------LLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSY---TLEDLKPDTLYRFQL 582

Query: 460 ILMNPEGRKESQELI-VQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLY 516
              +  G       I  +T +  P A P + +  S     + + W  P      GVIT Y
Sbjct: 583 AARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQY 642

Query: 517 EITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPAT 576
            + Y+AV   D    + +   R       + +   GL   T Y   +RA T  G GP ++
Sbjct: 643 SVAYEAVDGEDRGRHVVDGISR-----EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESS 697

Query: 577 NQFT-TKISAPSMPAYELET-PLNQTDNTVTVMLKPAHSRGAPVSVYQIV---VEEERPR 631
                T    PS P  ++E  PLN T   V   L     +   +  YQ+    +E   PR
Sbjct: 698 PVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPR 757


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score =  496 bits (1277), Expect = e-140
 Identities = 271/601 (45%), Positives = 369/601 (61%), Gaps = 14/601 (2%)

Query: 858  SHTYKKREPADVPYQTGQL--HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPW 915
            +H+    E   + YQT  +  HP I + DL  +I ++K  +G  F +EYES   GQ   W
Sbjct: 1299 AHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTW 1358

Query: 916  DSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPM 975
            +++  + N+ KNRY N+IAYDHSRV L +I+G   SDYIN NYIDGY + N YIATQGP+
Sbjct: 1359 ENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPL 1418

Query: 976  QETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAE 1034
             ET+ DFWRMVW + TA+++M+T L E  RVKC +YWP   TE    I+VTL++T  LA 
Sbjct: 1419 PETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELAT 1478

Query: 1035 YVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVH 1094
            Y +RTFA+ K G  E RE+RQF F  WPDHGVP + T +L F+R+VK+ +P  AGP+VVH
Sbjct: 1479 YTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVH 1538

Query: 1095 CSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEA 1154
            CSAG GRTGCFIVID ML+  + E  VDIY  V  +RS+R  MVQTE+QYVFIH+A+LEA
Sbjct: 1539 CSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEA 1598

Query: 1155 CLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNH 1214
              CG T VPA  + +    + ++ P  + + ++ EF+ L   +          A LP N 
Sbjct: 1599 ATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLL--ASSKAHTSRFISANLPCNK 1656

Query: 1215 EKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWR 1273
             KNR ++I+P +     L  I G E S+YINA+ +D Y+Q  A+I TQ PL  + +DFWR
Sbjct: 1657 FKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWR 1716

Query: 1274 LVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIY 1331
            ++ +++ T +VML  +     + C QYWP     R    Q   V    E ++   I R +
Sbjct: 1717 MLWEHNSTIIVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNMPQYILREF 1773

Query: 1332 NAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCL 1390
                 +DG  R ++QFQF  WP  +  P +   F+  I QV K +E++ G +G   VHC 
Sbjct: 1774 KVTDARDGQSRTIRQFQFTDWP-EQGVPKTGEGFIDFIGQVHKTKEQF-GQDGPITVHCS 1831

Query: 1391 NGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN 1450
             G GR+G F  +SIV E +R++  VD+F  VKTLR  +P MV   DQY+ CY  ALEYL 
Sbjct: 1832 AGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLG 1891

Query: 1451 S 1451
            S
Sbjct: 1892 S 1892



 Score =  137 bits (346), Expect = 6e-32
 Identities = 82/245 (33%), Positives = 126/245 (51%), Gaps = 13/245 (5%)

Query: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271
            N  KNR  +++  D     L +IDG   S+YINA  +D Y++ +A+I TQ PLP T+ DF
Sbjct: 1366 NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDF 1425

Query: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329
            WR+V +    +VVM+  ++      C QYWP  G    G IQV  +          R F 
Sbjct: 1426 WRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFA 1485

Query: 1330 IYNAARPQDGYRMVQQFQFLGWPMYR--DTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVV 1387
            ++ +   +   R ++QFQF+ WP +   + P    +FL+ ++  +          G  VV
Sbjct: 1486 LHKSGSSEK--RELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDA------GPMVV 1537

Query: 1388 HCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALE 1447
            HC  G GR+G F  I  + E ++H++TVD++  V  +R+ +  MV   DQY F +E  LE
Sbjct: 1538 HCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1597

Query: 1448 YLNSG 1452
                G
Sbjct: 1598 AATCG 1602



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 104/442 (23%), Positives = 175/442 (39%), Gaps = 46/442 (10%)

Query: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRD 254
           EV  G      C A+G  +   + W+ G +      KE ++   R  +   NVV +    
Sbjct: 242 EVMPGGSVNLTCVAVGAPMPYVK-WMMGAEELT---KEDEMPVGRNVLELSNVVRSAN-- 295

Query: 255 AGKYRCMIRTEGGVGISNYAELVVK---EPPVPIAPPQLASVGATYLWIQLNANSINGDG 311
              Y C+  +  G+ I   A++ VK   +PP+ +   +  +   T  W   N+       
Sbjct: 296 ---YTCVAISSLGM-IEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSE------ 345

Query: 312 PIVAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPA 369
           P+    ++Y  A   G + +   V +T Y IG L P +EY   VL       G G P  A
Sbjct: 346 PVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN--SIGRGPPSEA 403

Query: 370 LRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQV 429
           +R RT    P   PR+++   + +  + ++WEP          Y   V+Y       +  
Sbjct: 404 VRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYR--VYYT-----PDSR 456

Query: 430 REEVSWDTENSHP--QHTITNLSPYTNVSVKLILMNPEG-RKESQELIVQTDEDLPGAVP 486
           R   +W   N+      T+ +L P    S++++     G    S  + V+T + +P A P
Sbjct: 457 RPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQP 515

Query: 487 TESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNET 546
            +       + +I L W  P Q    I +YE+ Y A    D +  ++            +
Sbjct: 516 ADFQAEVESDTRIQLSWLLPPQER--IIMYELVYWAAEDEDQQHKVT--------FDPTS 565

Query: 547 HFLFFGLYPGTTYSFTIRASTAKGFGP-PATNQFTTKISAPSMPAYELE-TPLNQTDNTV 604
            +    L P T Y F + A +  G G    T +  T  S PS P  ++    +  T   V
Sbjct: 566 SYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRV 625

Query: 605 TVMLKPAHSRGAPVSVYQIVVE 626
           + +  PA SR   ++ Y +  E
Sbjct: 626 SWVPPPADSRNGVITQYSVAYE 647



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 83/354 (23%), Positives = 131/354 (37%), Gaps = 45/354 (12%)

Query: 257  KYRCMIR--TEGGVGISNYAELVVKEPPVPIAPPQLASVG-----ATYLWIQLNANSING 309
            +YR  +R  T+ G G  +   LV  +  VP  PP+   V      A +++ +L   S   
Sbjct: 679  EYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPS-KQ 737

Query: 310  DGPIVAREVEYCTASGSWNDRQPV-------DSTSYKIGHLDPDTEYEISVLL-TRPGEG 361
             G I   +V Y           P+       ++    I  L P+T Y ++V   T  G+G
Sbjct: 738  HGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDG 797

Query: 362  GTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCY 421
                P     T       + G   + +         ++W P          Y L   YC 
Sbjct: 798  ARSKPKIVTTTGA-----VPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRL--QYCR 850

Query: 422  QVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDL 481
                 E     + +  ++ H   T+T L   T    +L   N  G  E  E  ++T EDL
Sbjct: 851  ---ADEARPNTIDFGKDDQH--FTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDL 905

Query: 482  PGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEIDLSNQSGRV 539
            P   P              L W  P   +  G I  Y + ++ ++S   + +L N     
Sbjct: 906  PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINS---QQELQN----- 957

Query: 540  SKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYEL 593
              +  +T F   GL P TTY   +RA T+KG GP      +  I + +MP  ++
Sbjct: 958  --ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGP-----LSPSIQSRTMPVEQV 1004



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 88/441 (19%), Positives = 162/441 (36%), Gaps = 97/441 (21%)

Query: 379  PMRGPRKLEVVEVKSRQITIRWEP--FGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWD 436
            P   P+ L V  + +    + W+P        R  SY +       +  Q+++ + ++ D
Sbjct: 906  PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR---DINSQQEL-QNITTD 961

Query: 437  TENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFE 496
            T     + T+T L P T   +K+     +G       I      +           +  +
Sbjct: 962  T-----RFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMK 1016

Query: 497  EKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPG 556
              + L W  P  +Y     ++I Y   S    E+D           G+    L   L P 
Sbjct: 1017 TSVLLSWEVP-DSYKSAVPFKILYNGQSV---EVD-----------GHSMRKLIADLQPN 1061

Query: 557  TTYSFTI--RASTAKGFGP----------------PATNQFTTKISAPSMPA-------- 590
            T YSF +  R S+A G                   PA+          SMP         
Sbjct: 1062 TEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVR 1121

Query: 591  --YELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIV--VEE--ERPRRTKKTTEILKCYP 644
              Y +  P+++   +   ML P  S    + + +++  +E+  E  RR ++  E LK Y 
Sbjct: 1122 WFYIVVVPIDRVGGS---MLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPY- 1177

Query: 645  VPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQA 704
                             AA+         + FT+GD K Y G++N PL P  SY+ +  A
Sbjct: 1178 ----------------VAAQLDV----LPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLA 1217

Query: 705  ASRANGETKIDCVQVATKGAATP-------KPVPEPEKQTDHTVKIAGVIAGILLFVIIF 757
            + +   + K        + A++P       +  P  +++    + + G +  ++L ++I 
Sbjct: 1218 SLKEPMDQK--------RYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIV 1269

Query: 758  LGVVLVMKKRKLAKKRKETMS 778
            + ++L  +KR  +   K+  S
Sbjct: 1270 IAILLFKRKRTHSPSSKDEQS 1290



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 70/300 (23%), Positives = 113/300 (37%), Gaps = 25/300 (8%)

Query: 340 IGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIR 399
           +G L P   Y + VL       G G P P ++ +T+   P + P   +       +I + 
Sbjct: 475 VGSLLPGITYSLRVLAFTAV--GDGPPSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLS 531

Query: 400 WEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKL 459
           W      +       +     Y     E  + +V++D  +S+   T+ +L P T    +L
Sbjct: 532 W------LLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSY---TLEDLKPDTLYRFQL 582

Query: 460 ILMNPEGRKESQELI-VQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYGVITLY 516
              +  G       I  +T +  P A P + +  S     + + W  P      GVIT Y
Sbjct: 583 AARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQY 642

Query: 517 EITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPAT 576
            + Y+AV   D    + +   R       + +   GL   T Y   +RA T  G GP ++
Sbjct: 643 SVAYEAVDGEDRGRHVVDGISR-----EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESS 697

Query: 577 NQFT-TKISAPSMPAYELET-PLNQTDNTVTVMLKPAHSRGAPVSVYQIV---VEEERPR 631
                T    PS P  ++E  PLN T   V   L     +   +  YQ+    +E   PR
Sbjct: 698 PVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPR 757


>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  440 bits (1131), Expect = e-123
 Identities = 235/601 (39%), Positives = 361/601 (60%), Gaps = 21/601 (3%)

Query: 865  EPADVPY-----QTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQ-SAPWDSA 918
            EP  VP       T + +P + V  L + I +    +   F+EE+ +       A  ++A
Sbjct: 192  EPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAA 251

Query: 919  KKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQET 978
             K+EN+ KNRY NI+ YDHSRV L  +EG  +SDYIN ++I+GY   N +IA QGP +ET
Sbjct: 252  SKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEET 311

Query: 979  IYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAEYVI 1037
            + DFWRM+W +NTA+I+MVTNL E    KC +YWPD     Y +I+V++ +  +L +Y +
Sbjct: 312  VNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTV 371

Query: 1038 RTFAVEKRGVHEIRE----IRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVV 1093
            R F +++ G    R+    I QFHFT WPD GVP+   G+L F+++VK+ +P  AG +VV
Sbjct: 372  RKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVV 431

Query: 1094 HCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1153
            HCSAG GRTG F+VID MLDM   E  VD+Y  V  +R++R  MVQT+ QYVFI+ A+LE
Sbjct: 432  HCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE 491

Query: 1154 ACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRN 1213
              L GDT +  + + +    +    P T+++ ++EEF+ L  +   ++ +      LP N
Sbjct: 492  HYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPAN 549

Query: 1214 HEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFW 1272
             +KNR + I+P +     +    G E+++Y+NA+ +D Y+Q  ++I +Q PL +T++DFW
Sbjct: 550  MKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFW 609

Query: 1273 RLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRI 1330
            R++ ++   S+VML +++    + C QYWP +G+  +G I VE    +  E    R   +
Sbjct: 610  RMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLV 669

Query: 1331 YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCL 1390
             N    ++  R ++QF F GWP     P   +  + +I  V K Q++   G     VHC 
Sbjct: 670  TNTR--ENKSRQIRQFHFHGWPEV-GIPSDGKGMISIIAAVQKQQQQ--SGNHPITVHCS 724

Query: 1391 NGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN 1450
             G GR+GTFCA+S V E ++ +  +DVF  VK+LR  +P+MV  L+QY+FCY+V  EY++
Sbjct: 725  AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784

Query: 1451 S 1451
            +
Sbjct: 785  A 785


>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
            precursor [Homo sapiens]
          Length = 802

 Score =  440 bits (1131), Expect = e-123
 Identities = 235/601 (39%), Positives = 361/601 (60%), Gaps = 21/601 (3%)

Query: 865  EPADVPY-----QTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQ-SAPWDSA 918
            EP  VP       T + +P + V  L + I +    +   F+EE+ +       A  ++A
Sbjct: 201  EPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAA 260

Query: 919  KKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQET 978
             K+EN+ KNRY NI+ YDHSRV L  +EG  +SDYIN ++I+GY   N +IA QGP +ET
Sbjct: 261  SKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEET 320

Query: 979  IYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAEYVI 1037
            + DFWRM+W +NTA+I+MVTNL E    KC +YWPD     Y +I+V++ +  +L +Y +
Sbjct: 321  VNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTV 380

Query: 1038 RTFAVEKRGVHEIRE----IRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVV 1093
            R F +++ G    R+    I QFHFT WPD GVP+   G+L F+++VK+ +P  AG +VV
Sbjct: 381  RKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVV 440

Query: 1094 HCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1153
            HCSAG GRTG F+VID MLDM   E  VD+Y  V  +R++R  MVQT+ QYVFI+ A+LE
Sbjct: 441  HCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE 500

Query: 1154 ACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRN 1213
              L GDT +  + + +    +    P T+++ ++EEF+ L  +   ++ +      LP N
Sbjct: 501  HYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPAN 558

Query: 1214 HEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFW 1272
             +KNR + I+P +     +    G E+++Y+NA+ +D Y+Q  ++I +Q PL +T++DFW
Sbjct: 559  MKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFW 618

Query: 1273 RLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRI 1330
            R++ ++   S+VML +++    + C QYWP +G+  +G I VE    +  E    R   +
Sbjct: 619  RMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLV 678

Query: 1331 YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCL 1390
             N    ++  R ++QF F GWP     P   +  + +I  V K Q++   G     VHC 
Sbjct: 679  TNTR--ENKSRQIRQFHFHGWPEV-GIPSDGKGMISIIAAVQKQQQQ--SGNHPITVHCS 733

Query: 1391 NGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN 1450
             G GR+GTFCA+S V E ++ +  +DVF  VK+LR  +P+MV  L+QY+FCY+V  EY++
Sbjct: 734  AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 793

Query: 1451 S 1451
            +
Sbjct: 794  A 794


>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  440 bits (1131), Expect = e-123
 Identities = 235/601 (39%), Positives = 361/601 (60%), Gaps = 21/601 (3%)

Query: 865  EPADVPY-----QTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQ-SAPWDSA 918
            EP  VP       T + +P + V  L + I +    +   F+EE+ +       A  ++A
Sbjct: 192  EPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAA 251

Query: 919  KKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQET 978
             K+EN+ KNRY NI+ YDHSRV L  +EG  +SDYIN ++I+GY   N +IA QGP +ET
Sbjct: 252  SKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEET 311

Query: 979  IYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKVTLIETELLAEYVI 1037
            + DFWRM+W +NTA+I+MVTNL E    KC +YWPD     Y +I+V++ +  +L +Y +
Sbjct: 312  VNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTV 371

Query: 1038 RTFAVEKRGVHEIRE----IRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVV 1093
            R F +++ G    R+    I QFHFT WPD GVP+   G+L F+++VK+ +P  AG +VV
Sbjct: 372  RKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVV 431

Query: 1094 HCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1153
            HCSAG GRTG F+VID MLDM   E  VD+Y  V  +R++R  MVQT+ QYVFI+ A+LE
Sbjct: 432  HCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE 491

Query: 1154 ACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRN 1213
              L GDT +  + + +    +    P T+++ ++EEF+ L  +   ++ +      LP N
Sbjct: 492  HYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPAN 549

Query: 1214 HEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFW 1272
             +KNR + I+P +     +    G E+++Y+NA+ +D Y+Q  ++I +Q PL +T++DFW
Sbjct: 550  MKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFW 609

Query: 1273 RLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRI 1330
            R++ ++   S+VML +++    + C QYWP +G+  +G I VE    +  E    R   +
Sbjct: 610  RMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLV 669

Query: 1331 YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCL 1390
             N    ++  R ++QF F GWP     P   +  + +I  V K Q++   G     VHC 
Sbjct: 670  TNTR--ENKSRQIRQFHFHGWPEV-GIPSDGKGMISIIAAVQKQQQQ--SGNHPITVHCS 724

Query: 1391 NGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLN 1450
             G GR+GTFCA+S V E ++ +  +DVF  VK+LR  +P+MV  L+QY+FCY+V  EY++
Sbjct: 725  AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784

Query: 1451 S 1451
            +
Sbjct: 785  A 785


>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
            precursor [Homo sapiens]
          Length = 700

 Score =  423 bits (1087), Expect = e-118
 Identities = 235/562 (41%), Positives = 333/562 (59%), Gaps = 16/562 (2%)

Query: 900  FKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNY 958
            F+EE+ S   G     ++ A K+ENR KNRY NI+  DHSRV L  ++G   SDYIN +Y
Sbjct: 135  FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 194

Query: 959  IDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TE 1017
            IDGY   N +IA QGP QET+ DFWRMVW + +A+I+M+TNL E    KC +YWPD    
Sbjct: 195  IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 254

Query: 1018 IYKDIKVTLIETELLAEYVIRTFAVEKR---GVHEIREIRQFHFTGWPDHGVPYHATGLL 1074
             Y +I+V + +  +L +Y IR F ++ +   G    R + Q HFT WPD GVP+   G+L
Sbjct: 255  TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 314

Query: 1075 GFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRR 1134
             F+++VK+ +P  AGP+VVHCSAG GRTG FIVID M+ M   E  VD++  V  +R++R
Sbjct: 315  KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 374

Query: 1135 VNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLN 1194
              MVQT+ QY FI+ A+LE  L GDT +  S +      M+      +   ++EEFR L 
Sbjct: 375  PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 434

Query: 1195 MVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQ 1253
             V   +  E+     LP N +K R + I+P D     L    G E ++YINA+ +D Y+Q
Sbjct: 435  NV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 492

Query: 1254 PSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWPENGVHRHGPIQ 1311
               FI TQ PL +TV+DFWR++ ++   ++VML +V   +   C QYWP  G   HG I 
Sbjct: 493  KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEIT 552

Query: 1312 VEFVSADLEEDIISRIFRI---YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLI 1368
            +E  +  L E I  R F +      AR ++  R+V+QF F GWP     P   +  + LI
Sbjct: 553  IEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDLI 611

Query: 1369 RQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNK 1428
              V K Q++   G     VHC  G GR+GTF A+S + E ++ +  +DVF AVK+LR  +
Sbjct: 612  AAVQKQQQQ--TGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQR 669

Query: 1429 PNMVDLLDQYKFCYEVALEYLN 1450
            P+MV  L+QY+FCY+V  ++++
Sbjct: 670  PHMVQTLEQYEFCYKVVQDFID 691


>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
            [Homo sapiens]
          Length = 642

 Score =  423 bits (1087), Expect = e-118
 Identities = 235/562 (41%), Positives = 333/562 (59%), Gaps = 16/562 (2%)

Query: 900  FKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNY 958
            F+EE+ S   G     ++ A K+ENR KNRY NI+  DHSRV L  ++G   SDYIN +Y
Sbjct: 77   FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 136

Query: 959  IDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TE 1017
            IDGY   N +IA QGP QET+ DFWRMVW + +A+I+M+TNL E    KC +YWPD    
Sbjct: 137  IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 196

Query: 1018 IYKDIKVTLIETELLAEYVIRTFAVEKR---GVHEIREIRQFHFTGWPDHGVPYHATGLL 1074
             Y +I+V + +  +L +Y IR F ++ +   G    R + Q HFT WPD GVP+   G+L
Sbjct: 197  TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 256

Query: 1075 GFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRR 1134
             F+++VK+ +P  AGP+VVHCSAG GRTG FIVID M+ M   E  VD++  V  +R++R
Sbjct: 257  KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 316

Query: 1135 VNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLN 1194
              MVQT+ QY FI+ A+LE  L GDT +  S +      M+      +   ++EEFR L 
Sbjct: 317  PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 376

Query: 1195 MVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQ 1253
             V   +  E+     LP N +K R + I+P D     L    G E ++YINA+ +D Y+Q
Sbjct: 377  NV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 434

Query: 1254 PSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWPENGVHRHGPIQ 1311
               FI TQ PL +TV+DFWR++ ++   ++VML +V   +   C QYWP  G   HG I 
Sbjct: 435  KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEIT 494

Query: 1312 VEFVSADLEEDIISRIFRI---YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLI 1368
            +E  +  L E I  R F +      AR ++  R+V+QF F GWP     P   +  + LI
Sbjct: 495  IEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDLI 553

Query: 1369 RQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNK 1428
              V K Q++   G     VHC  G GR+GTF A+S + E ++ +  +DVF AVK+LR  +
Sbjct: 554  AAVQKQQQQ--TGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQR 611

Query: 1429 PNMVDLLDQYKFCYEVALEYLN 1450
            P+MV  L+QY+FCY+V  ++++
Sbjct: 612  PHMVQTLEQYEFCYKVVQDFID 633


>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
            precursor [Homo sapiens]
          Length = 2315

 Score =  377 bits (969), Expect = e-104
 Identities = 228/603 (37%), Positives = 346/603 (57%), Gaps = 45/603 (7%)

Query: 879  AIRVADLLQHITQMKCAEGYGFKEEYES----FFEGQSAPWD------SAKKDENRMKNR 928
            AI +    +H+  +  + G  F EE+E+    + E QS   D      S+   +N+ KNR
Sbjct: 1698 AIPIKHFPKHVADLHASSG--FTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNR 1755

Query: 929  YGNIIAYDHSRVRL-QTIEGDTN-SDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMV 986
            Y NI+AYDHSRV+L Q  E D   +DYIN NY+DGY+RP  YIA QGP++ T  DFWRM+
Sbjct: 1756 YINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMI 1815

Query: 987  WHENTASIIMVTNLVEVGRVKCCKYWP-DDTEIYKDIKVTLIETELLAEYVIRTFAVE-- 1043
            W  N   I+M+TNLVE GR KC +YWP D +E Y +  VT    ++LA Y +R F +   
Sbjct: 1816 WEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNT 1875

Query: 1044 ------KRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSA 1097
                  ++G    R + Q+H+T WPD GVP ++  +L FVR+       + GP+VVHCSA
Sbjct: 1876 KIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSA 1935

Query: 1098 GAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLC 1157
            G GRTG +IV+D ML   + EG V+I+  ++ +RS+R  +VQTEEQYVFIHD ++EA L 
Sbjct: 1936 GVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS 1995

Query: 1158 GDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKN 1217
             +T V  S + + Y +   +      ++++++F+ L+     ++  D S AL   N EKN
Sbjct: 1996 KETEVLDSHIHA-YVNALLIPGPAGKTKLEKQFQLLSQ--SNIQQSDYSAALKQCNREKN 2052

Query: 1218 RCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLD 1277
            R   I+P +R    + ++ GE ++YINA+ +  Y Q + FI+TQHPL +T+KDFWR++ D
Sbjct: 2053 RTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWD 2112

Query: 1278 YHCTSVVMLND-VDPAQLCPQYWPENGVHRHGPIQVEFVSADL---EEDIISR----IFR 1329
            ++   VVM+ D  + A+    YWP    ++  PI  E     L   E   +S     I +
Sbjct: 2113 HNAQLVVMIPDGQNMAEDEFVYWP----NKDEPINCESFKVTLMAEEHKCLSNEEKLIIQ 2168

Query: 1330 IYNAARPQDGYRM-VQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVH 1388
             +     QD Y + V+ FQ   WP   D+P+SK    +LI  +   +EE    +G  +VH
Sbjct: 2169 DFILEATQDDYVLEVRHFQCPKWP-NPDSPISKT--FELISVI---KEEAANRDGPMIVH 2222

Query: 1389 CLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY 1448
              +GG  +GTFCA++ +   L  + +VDV+   K +   +P +   ++QY+F Y+V L  
Sbjct: 2223 DEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL 2282

Query: 1449 LNS 1451
            +++
Sbjct: 2283 VST 2285



 Score =  130 bits (326), Expect = 1e-29
 Identities = 82/269 (30%), Positives = 131/269 (48%), Gaps = 17/269 (6%)

Query: 911  QSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIA 970
            Q + + +A K  NR KNR  +II  + SRV + ++ G+  +DYIN +YI GY++ N +I 
Sbjct: 2036 QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFII 2094

Query: 971  TQGPMQETIYDFWRMVWHENTASIIMVT---NLVEVGRVKCCKYWPDDTEIY--KDIKVT 1025
            TQ P+  TI DFWRM+W  N   ++M+    N+ E   V    YWP+  E    +  KVT
Sbjct: 2095 TQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV----YWPNKDEPINCESFKVT 2150

Query: 1026 LIETELLA-----EYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1080
            L+  E        + +I+ F +E      + E+R F    WP+   P   T  L  +  +
Sbjct: 2151 LMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFEL--ISVI 2208

Query: 1081 KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQT 1140
            K ++    GP++VH   G    G F  +  ++   E+E  VD+Y   + +   R  +   
Sbjct: 2209 KEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFAD 2268

Query: 1141 EEQYVFIHDAILEACLCGDTSVPASQVRS 1169
             EQY F++  IL          P++ + S
Sbjct: 2269 IEQYQFLYKVILSLVSTRQEENPSTSLDS 2297


>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
            [Homo sapiens]
          Length = 1445

 Score =  368 bits (945), Expect = e-101
 Identities = 220/599 (36%), Positives = 341/599 (56%), Gaps = 38/599 (6%)

Query: 879  AIRVADLLQHITQMKCAEGYGFKEEYESFFE---GQSAPWDSAKKDENRMKNRYGNIIAY 935
            AI V   ++HI ++     +GF E++E         +   + +   EN+ KNRY NI+AY
Sbjct: 827  AIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAY 886

Query: 936  DHSRVRLQTIEG--DTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTAS 993
            DHSRV+L+ + G    +SDYIN NY+DGY++   YIATQGP++ T  DFWRM+W +NT  
Sbjct: 887  DHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGI 946

Query: 994  IIMVTNLVEVGRVKCCKYWP-DDTEIYKDIKVTLIETELLAEYVIRTFAVEK-------- 1044
            I+M+TNLVE GR KC +YWP +++E Y +I VTL  T++ A Y +R F++          
Sbjct: 947  IVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQK 1006

Query: 1045 ---RGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGR 1101
               +G    R + Q+H+T WPD GVP +A  +L FVR+  +   P  GP++VHCSAG GR
Sbjct: 1007 GNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGR 1066

Query: 1102 TGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTS 1161
            TG +IVID ML   + +  V++   ++ +R++R  +VQTEEQY+FIHDA+LEA L  +T 
Sbjct: 1067 TGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE 1126

Query: 1162 VPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMD 1221
            V ++Q+ S Y +   +      ++++++F+ +       +  +C  A    N EKNR   
Sbjct: 1127 VSSNQLHS-YVNSILIPGVGGKTRLEKQFKLVTQC--NAKYVECFSAQKECNKEKNRNSS 1183

Query: 1222 ILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHC 1280
            ++P +R    L  + G + ++YINA+ +  Y + + FI+TQHPLP+T KDFWR++ D++ 
Sbjct: 1184 VVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNA 1243

Query: 1281 TSVVMLNDVDP-AQLCPQYWPENGVHRH-GPIQVEFVSADL-----EEDIISRIFRIYNA 1333
              +VML D    A+    YWP      +     V  +S D      EE II   F +   
Sbjct: 1244 QIIVMLPDNQSLAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFIL--- 1300

Query: 1334 ARPQDGYRM-VQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNG 1392
               QD Y + V+ FQ   WP   D P+S  S  +LI  +   +EE    +G T+VH   G
Sbjct: 1301 EATQDDYVLEVRHFQCPKWP-NPDAPIS--STFELINVI---KEEALTRDGPTIVHDEYG 1354

Query: 1393 GGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1451
               +G  CA++ + + L ++  VDVF   K +   +P +   ++QY+F Y+  L  +++
Sbjct: 1355 AVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST 1413


>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
            precursor [Homo sapiens]
          Length = 1256

 Score =  347 bits (889), Expect = 6e-95
 Identities = 211/598 (35%), Positives = 309/598 (51%), Gaps = 44/598 (7%)

Query: 883  ADLLQHITQMKCA-EGYGFKEEYESFFEGQSA-PWDSAKKDENRMKNRYGNIIAYDHSRV 940
            AD+L    + K A EG  F  E++S     S  P   A+K  N+ KNRY +I+ YD++RV
Sbjct: 585  ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRV 644

Query: 941  RLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNL 1000
             L  I GD  S+YIN +YIDG+  P  YIA QGP  ET+ DFWRM+W +    I+MVT  
Sbjct: 645  ELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRC 704

Query: 1001 VEVGRVKCCKYWP---DDTEIYKDIKVTLIETELLAEYVIRTF-AVEKRGVHEIREIRQF 1056
             E  R KC +YWP   + T  + D+ V + + +   +Y+I+    V K+     RE+   
Sbjct: 705  EEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHI 764

Query: 1057 HFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAE 1116
             FT WPDHGVP     LL   R+V + S   +GP+VVHCSAG GRTG +I ID ML+  E
Sbjct: 765  QFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLE 824

Query: 1117 REGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNK 1176
             E  VD+Y  V +LR +R  MVQ E QY+ IH A++E    G+T V  S++    ++M K
Sbjct: 825  AENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKK 884

Query: 1177 LDPQTNSSQIKEEFRTLNMVTPTLRV-EDCSIALLPRNHEKNRCMDILPPD-RCLPFLIT 1234
             DP +  S ++ EF+ L    P+ R      I     N  KNR  +++P D   +P    
Sbjct: 885  RDPPSEPSPLEAEFQRL----PSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHE 940

Query: 1235 ID-------------------GESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLV 1275
            ++                    E S YINA+ + SY +P   I  Q PL  T+ DFW+++
Sbjct: 941  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1000

Query: 1276 LDYHCTSVVMLNDV--DPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNA 1333
                   +VML ++     ++C QYW E G   +G I+V+    D       R+F + ++
Sbjct: 1001 FQRKVKVIVMLTELKHGDQEICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1059

Query: 1334 ARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGR-------TV 1386
             R     R V Q+Q+  W +    P   +  + +I+ V +   + N  EG         +
Sbjct: 1060 KRKDS--RTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1116

Query: 1387 VHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEV 1444
            +HC +G  ++G FCA+  + E    +  VD+F  VK LR  +P MV   +QY+F Y+V
Sbjct: 1117 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV 1174



 Score =  160 bits (405), Expect = 8e-39
 Identities = 94/306 (30%), Positives = 158/306 (51%), Gaps = 38/306 (12%)

Query: 920  KDENRMKNRYGNIIAYDHSRVRL---------------QTIEGDTNSD----YINGNYID 960
            ++EN+ KNR  N+I YD++RV L               ++ + D++S+    YIN ++I 
Sbjct: 915  QEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM 974

Query: 961  GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK 1020
             Y +P   IA QGP++ETI DFW+M++      I+M+T L    +  C +YW +  + Y 
Sbjct: 975  SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG 1034

Query: 1021 DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1080
            DI+V L +T+  + Y +R F +      + R + Q+ +T W    +P     L+  ++ V
Sbjct: 1035 DIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVV 1094

Query: 1081 KSKSPPS----------AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVREL 1130
            K K P            + PL++HC  G+ +TG F  +  +L+ AE E VVDI+  V+ L
Sbjct: 1095 KQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKAL 1154

Query: 1131 RSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPA--SQVRSLYYDMNKLDPQTNSSQIKE 1188
            R  R  MV T EQY F++D I        ++ PA   QV+   +  +K++      ++K+
Sbjct: 1155 RKARPGMVSTFEQYQFLYDVIA-------STYPAQNGQVKKNNHQEDKIEFDNEVDKVKQ 1207

Query: 1189 EFRTLN 1194
            +   +N
Sbjct: 1208 DANCVN 1213



 Score =  127 bits (318), Expect = 1e-28
 Identities = 89/269 (33%), Positives = 130/269 (48%), Gaps = 13/269 (4%)

Query: 1189 EFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAAL 1247
            EF+++  V     +++   A  P N  KNR +DILP D     L  I+G++ SNYINA+ 
Sbjct: 606  EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 662

Query: 1248 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWP--ENG 1303
            +D +K+P  +I  Q P   TV DFWR++ +   T +VM+   +      C +YWP  E G
Sbjct: 663  IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 722

Query: 1304 VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRS 1363
                G + V+        D I +   I N      G R V   QF  WP +   P     
Sbjct: 723  TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHL 780

Query: 1364 FLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKT 1423
             LKL R+V+ +   ++G     VVHC  G GR+GT+  I  + E L  +  VDV+  V  
Sbjct: 781  LLKLRRRVNAFSNFFSGP---IVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 837

Query: 1424 LRNNKPNMVDLLDQYKFCYEVALEYLNSG 1452
            LR  +  MV +  QY   ++  +EY   G
Sbjct: 838  LRRQRCLMVQVEAQYILIHQALVEYNQFG 866


>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
            precursor [Homo sapiens]
          Length = 1304

 Score =  347 bits (889), Expect = 6e-95
 Identities = 211/598 (35%), Positives = 309/598 (51%), Gaps = 44/598 (7%)

Query: 883  ADLLQHITQMKCA-EGYGFKEEYESFFEGQSA-PWDSAKKDENRMKNRYGNIIAYDHSRV 940
            AD+L    + K A EG  F  E++S     S  P   A+K  N+ KNRY +I+ YD++RV
Sbjct: 633  ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRV 692

Query: 941  RLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNL 1000
             L  I GD  S+YIN +YIDG+  P  YIA QGP  ET+ DFWRM+W +    I+MVT  
Sbjct: 693  ELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRC 752

Query: 1001 VEVGRVKCCKYWP---DDTEIYKDIKVTLIETELLAEYVIRTF-AVEKRGVHEIREIRQF 1056
             E  R KC +YWP   + T  + D+ V + + +   +Y+I+    V K+     RE+   
Sbjct: 753  EEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHI 812

Query: 1057 HFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAE 1116
             FT WPDHGVP     LL   R+V + S   +GP+VVHCSAG GRTG +I ID ML+  E
Sbjct: 813  QFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLE 872

Query: 1117 REGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNK 1176
             E  VD+Y  V +LR +R  MVQ E QY+ IH A++E    G+T V  S++    ++M K
Sbjct: 873  AENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKK 932

Query: 1177 LDPQTNSSQIKEEFRTLNMVTPTLRV-EDCSIALLPRNHEKNRCMDILPPD-RCLPFLIT 1234
             DP +  S ++ EF+ L    P+ R      I     N  KNR  +++P D   +P    
Sbjct: 933  RDPPSEPSPLEAEFQRL----PSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHE 988

Query: 1235 ID-------------------GESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLV 1275
            ++                    E S YINA+ + SY +P   I  Q PL  T+ DFW+++
Sbjct: 989  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 1048

Query: 1276 LDYHCTSVVMLNDV--DPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNA 1333
                   +VML ++     ++C QYW E G   +G I+V+    D       R+F + ++
Sbjct: 1049 FQRKVKVIVMLTELKHGDQEICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 1107

Query: 1334 ARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGR-------TV 1386
             R     R V Q+Q+  W +    P   +  + +I+ V +   + N  EG         +
Sbjct: 1108 KRKDS--RTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1164

Query: 1387 VHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEV 1444
            +HC +G  ++G FCA+  + E    +  VD+F  VK LR  +P MV   +QY+F Y+V
Sbjct: 1165 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV 1222



 Score =  160 bits (405), Expect = 8e-39
 Identities = 94/306 (30%), Positives = 158/306 (51%), Gaps = 38/306 (12%)

Query: 920  KDENRMKNRYGNIIAYDHSRVRL---------------QTIEGDTNSD----YINGNYID 960
            ++EN+ KNR  N+I YD++RV L               ++ + D++S+    YIN ++I 
Sbjct: 963  QEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM 1022

Query: 961  GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK 1020
             Y +P   IA QGP++ETI DFW+M++      I+M+T L    +  C +YW +  + Y 
Sbjct: 1023 SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG 1082

Query: 1021 DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1080
            DI+V L +T+  + Y +R F +      + R + Q+ +T W    +P     L+  ++ V
Sbjct: 1083 DIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVV 1142

Query: 1081 KSKSPPS----------AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVREL 1130
            K K P            + PL++HC  G+ +TG F  +  +L+ AE E VVDI+  V+ L
Sbjct: 1143 KQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKAL 1202

Query: 1131 RSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPA--SQVRSLYYDMNKLDPQTNSSQIKE 1188
            R  R  MV T EQY F++D I        ++ PA   QV+   +  +K++      ++K+
Sbjct: 1203 RKARPGMVSTFEQYQFLYDVIA-------STYPAQNGQVKKNNHQEDKIEFDNEVDKVKQ 1255

Query: 1189 EFRTLN 1194
            +   +N
Sbjct: 1256 DANCVN 1261



 Score =  127 bits (318), Expect = 1e-28
 Identities = 89/269 (33%), Positives = 130/269 (48%), Gaps = 13/269 (4%)

Query: 1189 EFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAAL 1247
            EF+++  V     +++   A  P N  KNR +DILP D     L  I+G++ SNYINA+ 
Sbjct: 654  EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 710

Query: 1248 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWP--ENG 1303
            +D +K+P  +I  Q P   TV DFWR++ +   T +VM+   +      C +YWP  E G
Sbjct: 711  IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 770

Query: 1304 VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRS 1363
                G + V+        D I +   I N      G R V   QF  WP +   P     
Sbjct: 771  TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHL 828

Query: 1364 FLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKT 1423
             LKL R+V+ +   ++G     VVHC  G GR+GT+  I  + E L  +  VDV+  V  
Sbjct: 829  LLKLRRRVNAFSNFFSGP---IVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 885

Query: 1424 LRNNKPNMVDLLDQYKFCYEVALEYLNSG 1452
            LR  +  MV +  QY   ++  +EY   G
Sbjct: 886  LRRQRCLMVQVEAQYILIHQALVEYNQFG 914


>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
            precursor [Homo sapiens]
          Length = 1143

 Score =  347 bits (889), Expect = 6e-95
 Identities = 211/598 (35%), Positives = 309/598 (51%), Gaps = 44/598 (7%)

Query: 883  ADLLQHITQMKCA-EGYGFKEEYESFFEGQSA-PWDSAKKDENRMKNRYGNIIAYDHSRV 940
            AD+L    + K A EG  F  E++S     S  P   A+K  N+ KNRY +I+ YD++RV
Sbjct: 472  ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRV 531

Query: 941  RLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNL 1000
             L  I GD  S+YIN +YIDG+  P  YIA QGP  ET+ DFWRM+W +    I+MVT  
Sbjct: 532  ELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRC 591

Query: 1001 VEVGRVKCCKYWP---DDTEIYKDIKVTLIETELLAEYVIRTF-AVEKRGVHEIREIRQF 1056
             E  R KC +YWP   + T  + D+ V + + +   +Y+I+    V K+     RE+   
Sbjct: 592  EEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHI 651

Query: 1057 HFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAE 1116
             FT WPDHGVP     LL   R+V + S   +GP+VVHCSAG GRTG +I ID ML+  E
Sbjct: 652  QFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLE 711

Query: 1117 REGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNK 1176
             E  VD+Y  V +LR +R  MVQ E QY+ IH A++E    G+T V  S++    ++M K
Sbjct: 712  AENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKK 771

Query: 1177 LDPQTNSSQIKEEFRTLNMVTPTLRV-EDCSIALLPRNHEKNRCMDILPPD-RCLPFLIT 1234
             DP +  S ++ EF+ L    P+ R      I     N  KNR  +++P D   +P    
Sbjct: 772  RDPPSEPSPLEAEFQRL----PSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHE 827

Query: 1235 ID-------------------GESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLV 1275
            ++                    E S YINA+ + SY +P   I  Q PL  T+ DFW+++
Sbjct: 828  LEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMI 887

Query: 1276 LDYHCTSVVMLNDV--DPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNA 1333
                   +VML ++     ++C QYW E G   +G I+V+    D       R+F + ++
Sbjct: 888  FQRKVKVIVMLTELKHGDQEICAQYWGE-GKQTYGDIEVDLKDTDKSSTYTLRVFELRHS 946

Query: 1334 ARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGR-------TV 1386
             R     R V Q+Q+  W +    P   +  + +I+ V +   + N  EG         +
Sbjct: 947  KRKDS--RTVYQYQYTNWSV-EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLL 1003

Query: 1387 VHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEV 1444
            +HC +G  ++G FCA+  + E    +  VD+F  VK LR  +P MV   +QY+F Y+V
Sbjct: 1004 IHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDV 1061



 Score =  160 bits (405), Expect = 8e-39
 Identities = 94/306 (30%), Positives = 158/306 (51%), Gaps = 38/306 (12%)

Query: 920  KDENRMKNRYGNIIAYDHSRVRL---------------QTIEGDTNSD----YINGNYID 960
            ++EN+ KNR  N+I YD++RV L               ++ + D++S+    YIN ++I 
Sbjct: 802  QEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIM 861

Query: 961  GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK 1020
             Y +P   IA QGP++ETI DFW+M++      I+M+T L    +  C +YW +  + Y 
Sbjct: 862  SYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYG 921

Query: 1021 DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV 1080
            DI+V L +T+  + Y +R F +      + R + Q+ +T W    +P     L+  ++ V
Sbjct: 922  DIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVV 981

Query: 1081 KSKSPPS----------AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVREL 1130
            K K P            + PL++HC  G+ +TG F  +  +L+ AE E VVDI+  V+ L
Sbjct: 982  KQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKAL 1041

Query: 1131 RSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPA--SQVRSLYYDMNKLDPQTNSSQIKE 1188
            R  R  MV T EQY F++D I        ++ PA   QV+   +  +K++      ++K+
Sbjct: 1042 RKARPGMVSTFEQYQFLYDVIA-------STYPAQNGQVKKNNHQEDKIEFDNEVDKVKQ 1094

Query: 1189 EFRTLN 1194
            +   +N
Sbjct: 1095 DANCVN 1100



 Score =  127 bits (318), Expect = 1e-28
 Identities = 89/269 (33%), Positives = 130/269 (48%), Gaps = 13/269 (4%)

Query: 1189 EFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGES-SNYINAAL 1247
            EF+++  V     +++   A  P N  KNR +DILP D     L  I+G++ SNYINA+ 
Sbjct: 493  EFQSIPRVFSKFPIKE---ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASY 549

Query: 1248 MDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQL--CPQYWP--ENG 1303
            +D +K+P  +I  Q P   TV DFWR++ +   T +VM+   +      C +YWP  E G
Sbjct: 550  IDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEG 609

Query: 1304 VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRS 1363
                G + V+        D I +   I N      G R V   QF  WP +   P     
Sbjct: 610  TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHL 667

Query: 1364 FLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKT 1423
             LKL R+V+ +   ++G     VVHC  G GR+GT+  I  + E L  +  VDV+  V  
Sbjct: 668  LLKLRRRVNAFSNFFSGP---IVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVK 724

Query: 1424 LRNNKPNMVDLLDQYKFCYEVALEYLNSG 1452
            LR  +  MV +  QY   ++  +EY   G
Sbjct: 725  LRRQRCLMVQVEAQYILIHQALVEYNQFG 753


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,292,799
Number of Sequences: 37866
Number of extensions: 2758485
Number of successful extensions: 9675
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 130
Number of HSP's successfully gapped in prelim test: 163
Number of HSP's that attempted gapping in prelim test: 7311
Number of HSP's gapped (non-prelim): 1441
length of query: 1452
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1337
effective length of database: 13,892,928
effective search space: 18574844736
effective search space used: 18574844736
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.