Search of human proteins with 157388902

Search of human proteins with 157388902

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157388902 semaphorin 4C [Homo sapiens]
         (833 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157388902 semaphorin 4C [Homo sapiens]                            1732   0.0  
gi|28872814 semaphorin 4G [Homo sapiens]                              528   e-149
gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]                   484   e-136
gi|39777610 semaphorin 4B precursor [Homo sapiens]                    480   e-135
gi|39777608 semaphorin 4B precursor [Homo sapiens]                    480   e-135
gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]                   469   e-132
gi|19923279 semaphorin W [Homo sapiens]                               408   e-113
gi|21361914 semaphorin B [Homo sapiens]                               401   e-111
gi|5174673 semaphorin 3A precursor [Homo sapiens]                     355   1e-97
gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]           348   2e-95
gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]          344   2e-94
gi|41406086 semaphorin 3D [Homo sapiens]                              338   9e-93
gi|9910362 semaphorin sem2 [Homo sapiens]                             319   6e-87
gi|6912650 semaphorin 3E [Homo sapiens]                               315   1e-85
gi|188497703 semaphorin 3F [Homo sapiens]                             313   5e-85
gi|5454048 semaphorin 3C [Homo sapiens]                               300   5e-81
gi|147904700 semaphorin 5A [Homo sapiens]                             274   3e-73
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]                    270   3e-72
gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]          268   2e-71
gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]          268   2e-71
gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]          268   2e-71
gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]          268   2e-71
gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]          268   2e-71
gi|16306552 semaphorin Y [Homo sapiens]                               261   1e-69
gi|11991660 sema domain, transmembrane domain (TM), and cytoplas...   254   2e-67
gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]          238   1e-62
gi|19718780 semaphorin 6B precursor [Homo sapiens]                    236   5e-62
gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]     167   3e-41
gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]       165   2e-40
gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]                   153   6e-37

>gi|157388902 semaphorin 4C [Homo sapiens]
          Length = 833

 Score = 1732 bits (4486), Expect = 0.0
 Identities = 833/833 (100%), Positives = 833/833 (100%)

Query: 1   MAPHWAVWLLAARLWGLGIGAEVWWNLVPRKTVSSGELATVVRRFSQTGIQDFLTLTLTE 60
           MAPHWAVWLLAARLWGLGIGAEVWWNLVPRKTVSSGELATVVRRFSQTGIQDFLTLTLTE
Sbjct: 1   MAPHWAVWLLAARLWGLGIGAEVWWNLVPRKTVSSGELATVVRRFSQTGIQDFLTLTLTE 60

Query: 61  PTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPY 120
           PTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPY
Sbjct: 61  PTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPY 120

Query: 121 NASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSAT 180
           NASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSAT
Sbjct: 121 NASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSAT 180

Query: 181 LNNFLGTEPIILRNMGPHHSMKTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFR 240
           LNNFLGTEPIILRNMGPHHSMKTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFR
Sbjct: 181 LNNFLGTEPIILRNMGPHHSMKTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFR 240

Query: 241 ERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAPNWQLYFNQLQAM 300
           ERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAPNWQLYFNQLQAM
Sbjct: 241 ERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAPNWQLYFNQLQAM 300

Query: 301 HTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTD 360
           HTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTD
Sbjct: 301 HTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTD 360

Query: 361 PVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNF 420
           PVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNF
Sbjct: 361 PVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNF 420

Query: 421 THLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQEPMRSLVLSQS 480
           THLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQEPMRSLVLSQS
Sbjct: 421 THLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQEPMRSLVLSQS 480

Query: 481 KKLLFAGSRSQLVQLPVADCMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLLIQH 540
           KKLLFAGSRSQLVQLPVADCMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLLIQH
Sbjct: 481 KKLLFAGSRSQLVQLPVADCMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLLIQH 540

Query: 541 VMTSDTSGICNLRGSKKVRPTPKNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQP 600
           VMTSDTSGICNLRGSKKVRPTPKNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQP
Sbjct: 541 VMTSDTSGICNLRGSKKVRPTPKNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQP 600

Query: 601 GSFLYDARLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLVAVVAGPSVTLEARAPLE 660
           GSFLYDARLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLVAVVAGPSVTLEARAPLE
Sbjct: 601 GSFLYDARLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLVAVVAGPSVTLEARAPLE 660

Query: 661 NLGLVWLAVVALGAVCLVLLLLVLSLRRRLREELEKGAKATERTLVYPLELPKEPTSPPF 720
           NLGLVWLAVVALGAVCLVLLLLVLSLRRRLREELEKGAKATERTLVYPLELPKEPTSPPF
Sbjct: 661 NLGLVWLAVVALGAVCLVLLLLVLSLRRRLREELEKGAKATERTLVYPLELPKEPTSPPF 720

Query: 721 RPCPEPDEKLWDPVGYYYSDGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGG 780
           RPCPEPDEKLWDPVGYYYSDGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGG
Sbjct: 721 RPCPEPDEKLWDPVGYYYSDGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGG 780

Query: 781 GRNSNANGYVRLQLGGEDRGGLGHPLPELADELRRKLQQRQPLPDSNPEESSV 833
           GRNSNANGYVRLQLGGEDRGGLGHPLPELADELRRKLQQRQPLPDSNPEESSV
Sbjct: 781 GRNSNANGYVRLQLGGEDRGGLGHPLPELADELRRKLQQRQPLPDSNPEESSV 833


>gi|28872814 semaphorin 4G [Homo sapiens]
          Length = 843

 Score =  528 bits (1359), Expect = e-149
 Identities = 337/829 (40%), Positives = 446/829 (53%), Gaps = 68/829 (8%)

Query: 29  PRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGA-- 86
           PR T+   EL+    R  +   Q++ TL L E +  L VGAR ALF+ S   +   GA  
Sbjct: 34  PRMTIPYEELSGT--RHFKGQAQNYSTLLLEEASARLLVGARGALFSLSANDIG-DGAHK 90

Query: 87  -ISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNMLTF 145
            I WEA  E +++C QKGKNNQTECFN +RFLQ  N++HLY CGT+AFQP C  ++   F
Sbjct: 91  EIHWEASPEMQSKCHQKGKNNQTECFNHVRFLQRLNSTHLYACGTHAFQPLCAAIDAEAF 150

Query: 146 TLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKTEY 205
           TL    FE+GK KCPYDPA+G  GL++DG LY+AT   F    P I R+  PH     E 
Sbjct: 151 TLPTS-FEEGKEKCPYDPARGFTGLIIDGGLYTATRYEFRSI-PDIRRSRHPHSLRTEET 208

Query: 206 LAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVE------SDCYAEQVVARVAR 259
              WLN+  FV S  V ES  S  GDDDKVY+FF ERA E      +   +   VARVAR
Sbjct: 209 PMHWLNDAEFVFSVLVRESKASAVGDDDKVYYFFTERATEEGSGSFTQSRSSHRVARVAR 268

Query: 260 VCKGDMGGARTLQRKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVF-- 317
           VCKGD+GG + LQ+KWT+FLKARL C  P     +  L+ + +L   +   T F+  F  
Sbjct: 269 VCKGDLGGKKILQKKWTSFLKARLICHIP----LYETLRGVCSLDAETSSRTHFYAAFTL 324

Query: 318 QAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRR 377
             QW  +  SAIC Y L EIQ VF GPY EY + +++W RY   VP PRPGSCI +  R 
Sbjct: 325 STQWKTLEASAICRYDLAEIQAVFAGPYMEYQDGSRRWGRYEGGVPEPRPGSCITDSLRS 384

Query: 378 HGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYT 437
            GY SS +LP  +L+FVK HPLM   V P   RPLL+K+   +THL    VT   G TY 
Sbjct: 385 QGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNIRYTHLTGTPVTTPAGPTYD 444

Query: 438 VLFIGTGDGWLLKAVSLGPWVHLIEELQLF-DQEPMRSLVLSQSKKLLFAGSRSQLVQLP 496
           +LF+GT DGW+ KAV LG  +H+IEE Q+F + + + +LV+S  +  L+ G+ S ++QLP
Sbjct: 445 LLFLGTADGWIHKAVVLGSGMHIIEETQVFRESQSVENLVISLLQHSLYVGAPSGVIQLP 504

Query: 497 VADCMKYRSCADCVLARDPYCAWSVNTSRCVAV------GGHSGSLLIQHVMTSDTSGIC 550
           ++ C +YRSC DC+LARDPYC W   T  C A          S + LIQ +      G  
Sbjct: 505 LSSCSRYRSCYDCILARDPYCGWDPGTHACAAATTIANRSQGSRTALIQDI----ERGNR 560

Query: 551 NLRGSKKVRPTP--KNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLYDAR 608
               S+   P P  K  +V+ G D++LPC   SNLA A W   G    ++  G   Y   
Sbjct: 561 GCESSRDTGPPPPLKTRSVLRGDDVLLPCDQPSNLARALWLLNGSMGLSDGQGG--YRVG 618

Query: 609 LQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLVAV-VAGPSVTLEARA-PLENLG--- 663
           +  L+V  AQP H+G Y C++EE G R     Y + V  A P+   +A A P   L    
Sbjct: 619 VDGLLVTDAQPEHSGNYGCYAEENGLRTLLASYSLTVRPATPAPAPKAPATPGAQLAPDV 678

Query: 664 --LVWLAVVALGAVCLVL---LLLVLSLR-----RRLREELEKGAKATERTLVYPLELPK 713
             L  LA+ ALG +CL+L   LL V  LR     RR +  L + ++A    +        
Sbjct: 679 RLLYVLAIAALGGLCLILASSLLYVACLREGRRGRRRKYSLGRASRAGGSAV-------- 730

Query: 714 EPTSPPFRPCPEPDEKLWDPVGYYYSDGSLKIVPGHARCQPGGGPPSPPPG-IPGQPLPS 772
                    CP  +++  D          L+I+PG     P   PP PPP  +    +  
Sbjct: 731 -QLQTVSGQCPGEEDEGDDEGAGGLEGSCLQIIPGEGAPAPPPPPPPPPPAELTNGLVAL 789

Query: 773 PTRLHLGGGRNSNANGYVRLQLGGEDRGGLGHPLPELADELRRKLQQRQ 821
           P+RL     R  N N YV L+   +   G+       A+EL R L++R+
Sbjct: 790 PSRL-----RRMNGNSYVLLR---QSNNGVPAGPCSFAEELSRILEKRK 830


>gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]
          Length = 862

 Score =  484 bits (1247), Expect = e-136
 Identities = 275/614 (44%), Positives = 369/614 (60%), Gaps = 20/614 (3%)

Query: 28  VPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFS-MEALELQGA 86
           +PR T    E+  V  +F +  I ++  L L+E    LY+GAREA+FA + +   E Q  
Sbjct: 27  IPRITWEHREVHLV--QFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHE 84

Query: 87  ISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNMLTFT 146
           + W+   +KK +C +KGK+ QTEC N+IR LQP +A+ LYVCGT AFQP C ++N+ +F 
Sbjct: 85  VYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFK 144

Query: 147 LEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKTEYL 206
              G+ EDGKG+CP+DPA  +  ++VDGELYS T  NFLG+EPII RN   H  ++TEY 
Sbjct: 145 FL-GKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSS-HSPLRTEYA 202

Query: 207 AFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMG 266
             WLNEP FV +  + +S  S  G+DD+VYFFF E +VE +     ++ R+ARVCKGD G
Sbjct: 203 IPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQG 262

Query: 267 GARTLQRKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYL 326
           G RTLQ+KWT+FLKARL CS P+  L FN L+ +  L+        F+ +F  Q  ++ L
Sbjct: 263 GLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGL 322

Query: 327 SAICEYQLEEIQRVF-EGPYKE---YHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTS 382
           SA+C Y L   + VF  G Y +     +   KW RY  PVP PRPG+CI++  R   YTS
Sbjct: 323 SAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTS 382

Query: 383 SLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIG 442
           SL LPD  L FVK HPLM++ V P  +RP L+KK  N+T +V DR   LDG  Y V+F+ 
Sbjct: 383 SLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVS 442

Query: 443 TGDGWLLKAVSLGPWVHLIEELQLF-DQEPMRSLVLSQSK--KLLFAGSRSQLVQLPVAD 499
           T  G L KA+SL   VH+IEE QLF D EP+++L+LS  K  + ++AGS S +VQ P+A 
Sbjct: 443 TDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAF 502

Query: 500 CMKYRSCADCVLARDPYCAWSVNTSRCVAV-GGHSGSLLIQHVMTSDTSGICNLRGSKKV 558
           C K+ +C DCVLARDPYCAWS  T+ CVA+    S S  +   M+ D S +C      K 
Sbjct: 503 CGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDAS-VC----PDKS 557

Query: 559 RPTPKNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLYDARLQALVVMAAQ 618
           + + +      G    L C   SNLA   W F    L AE P   L   +   L++    
Sbjct: 558 KGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGLMGRK--NLLIFNLS 615

Query: 619 PRHAGAYHCFSEEQ 632
              +G Y C SEE+
Sbjct: 616 EGDSGVYQCLSEER 629


>gi|39777610 semaphorin 4B precursor [Homo sapiens]
          Length = 837

 Score =  480 bits (1236), Expect = e-135
 Identities = 300/740 (40%), Positives = 401/740 (54%), Gaps = 63/740 (8%)

Query: 25  WNLVPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQ 84
           W L PR ++  G       RF    I ++  L L+     LYVGAREALFA S     L 
Sbjct: 42  WALSPRISLPLGSEERPFLRFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLP 101

Query: 85  GA----ISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYV 140
           G     + W A  EKK +C  KGK+ Q +C N+I+ L P + SHL+ CGT AF P CTY+
Sbjct: 102 GGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYI 161

Query: 141 NMLTFTLEHGE-----FEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNM 195
           NM  FTL   E      EDGKG+CP+DP      L+VDGELY+ T+++F G +P I R+ 
Sbjct: 162 NMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQ 221

Query: 196 GPHHSMKTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVA 255
               + KTE    WL +P FV SAY+PES+GS  GDDDK+YFFF E   E + +   +V+
Sbjct: 222 SLRPT-KTESSLNWLQDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVS 280

Query: 256 RVARVCKGDMGGARTLQRKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDT--SWHNTTF 313
           R+AR+CKGD GG R LQ++WT+FLKA+L CS P+    FN LQ + TL  +   W +T F
Sbjct: 281 RIARICKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLF 340

Query: 314 FGVFQAQW--GDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCI 371
           +GVF +QW  G    SA+C + ++++QRVF G YKE + E Q+W   T PVP+PRPG+CI
Sbjct: 341 YGVFTSQWHRGTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACI 400

Query: 372 NNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGL 431
            N  R     SSL+LPD +LNF+K H LM+ QV    SR LL++    +  +   RV GL
Sbjct: 401 TNSARERKINSSLQLPDRVLNFLKDHFLMDGQVR---SRMLLLQPQARYQRVAVHRVPGL 457

Query: 432 DGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQ-EPMRSLVLSQSKKLLFAGSRS 490
              TY VLF+GTGDG L KAVS+GP VH+IEELQ+F   +P+++L+L   + LL+A S S
Sbjct: 458 H-HTYDVLFLGTGDGRLHKAVSVGPRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHS 516

Query: 491 QLVQLPVADCMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLL----IQHVMTSDT 546
            +VQ+P+A+C  YRSC DC+LARDPYCAWS   S C  V  +   L     IQ +  +  
Sbjct: 517 GVVQVPMANCSLYRSCGDCLLARDPYCAWS--GSSCKHVSLYQPQLATRPWIQDIEGASA 574

Query: 547 SGICNLRG--SKKVRPTP----KNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQP 600
             +C+     S    PT     + +     T   L C L SNLA   W   G  + A   
Sbjct: 575 KDLCSASSVVSPSFVPTGEKPCEQVQFQPNTVNTLACPLLSNLATRLWLRNGAPVNASAS 634

Query: 601 GSFLYDARLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLVAVV---------AGPSV 651
              L    L     +    +  G + C+S E+G +     Y   VV          G SV
Sbjct: 635 CHVLPTGDL-----LLVGTQQLGEFQCWSLEEGFQQLVASYCPEVVEDGVADQTDEGGSV 689

Query: 652 -----TLEARAPLENLG------------LVWLAVVALGAVCLVLLLLVLSLRRRLREEL 694
                T    AP                 LV   +  L AV L +L L+   R  ++  L
Sbjct: 690 PVIISTSRVSAPAGGKASWGADRSYWKEFLVMCTLFVL-AVLLPVLFLLYRHRNSMKVFL 748

Query: 695 EKGAKATERTLVYPLELPKE 714
           ++G  A+      P+ LP E
Sbjct: 749 KQGECASVHPKTCPVVLPPE 768


>gi|39777608 semaphorin 4B precursor [Homo sapiens]
          Length = 837

 Score =  480 bits (1236), Expect = e-135
 Identities = 300/740 (40%), Positives = 401/740 (54%), Gaps = 63/740 (8%)

Query: 25  WNLVPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQ 84
           W L PR ++  G       RF    I ++  L L+     LYVGAREALFA S     L 
Sbjct: 42  WALSPRISLPLGSEERPFLRFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLP 101

Query: 85  GA----ISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYV 140
           G     + W A  EKK +C  KGK+ Q +C N+I+ L P + SHL+ CGT AF P CTY+
Sbjct: 102 GGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYI 161

Query: 141 NMLTFTLEHGE-----FEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNM 195
           NM  FTL   E      EDGKG+CP+DP      L+VDGELY+ T+++F G +P I R+ 
Sbjct: 162 NMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQ 221

Query: 196 GPHHSMKTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVA 255
               + KTE    WL +P FV SAY+PES+GS  GDDDK+YFFF E   E + +   +V+
Sbjct: 222 SLRPT-KTESSLNWLQDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVS 280

Query: 256 RVARVCKGDMGGARTLQRKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDT--SWHNTTF 313
           R+AR+CKGD GG R LQ++WT+FLKA+L CS P+    FN LQ + TL  +   W +T F
Sbjct: 281 RIARICKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLF 340

Query: 314 FGVFQAQW--GDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCI 371
           +GVF +QW  G    SA+C + ++++QRVF G YKE + E Q+W   T PVP+PRPG+CI
Sbjct: 341 YGVFTSQWHRGTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACI 400

Query: 372 NNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGL 431
            N  R     SSL+LPD +LNF+K H LM+ QV    SR LL++    +  +   RV GL
Sbjct: 401 TNSARERKINSSLQLPDRVLNFLKDHFLMDGQVR---SRMLLLQPQARYQRVAVHRVPGL 457

Query: 432 DGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQ-EPMRSLVLSQSKKLLFAGSRS 490
              TY VLF+GTGDG L KAVS+GP VH+IEELQ+F   +P+++L+L   + LL+A S S
Sbjct: 458 H-HTYDVLFLGTGDGRLHKAVSVGPRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHS 516

Query: 491 QLVQLPVADCMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLL----IQHVMTSDT 546
            +VQ+P+A+C  YRSC DC+LARDPYCAWS   S C  V  +   L     IQ +  +  
Sbjct: 517 GVVQVPMANCSLYRSCGDCLLARDPYCAWS--GSSCKHVSLYQPQLATRPWIQDIEGASA 574

Query: 547 SGICNLRG--SKKVRPTP----KNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQP 600
             +C+     S    PT     + +     T   L C L SNLA   W   G  + A   
Sbjct: 575 KDLCSASSVVSPSFVPTGEKPCEQVQFQPNTVNTLACPLLSNLATRLWLRNGAPVNASAS 634

Query: 601 GSFLYDARLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLVAVV---------AGPSV 651
              L    L     +    +  G + C+S E+G +     Y   VV          G SV
Sbjct: 635 CHVLPTGDL-----LLVGTQQLGEFQCWSLEEGFQQLVASYCPEVVEDGVADQTDEGGSV 689

Query: 652 -----TLEARAPLENLG------------LVWLAVVALGAVCLVLLLLVLSLRRRLREEL 694
                T    AP                 LV   +  L AV L +L L+   R  ++  L
Sbjct: 690 PVIISTSRVSAPAGGKASWGADRSYWKEFLVMCTLFVL-AVLLPVLFLLYRHRNSMKVFL 748

Query: 695 EKGAKATERTLVYPLELPKE 714
           ++G  A+      P+ LP E
Sbjct: 749 KQGECASVHPKTCPVVLPPE 768


>gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]
          Length = 738

 Score =  469 bits (1208), Expect = e-132
 Identities = 260/573 (45%), Positives = 350/573 (61%), Gaps = 25/573 (4%)

Query: 28  VPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFS-MEALELQGA 86
           +PR T    E+  V  +F +  I ++  L L+E    LY+GAREA+FA + +   E Q  
Sbjct: 27  IPRITWEHREVHLV--QFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHE 84

Query: 87  ISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNMLTFT 146
           + W+   +KK +C +KGK+ QTEC N+IR LQP +A+ LYVCGT AFQP C ++N+ +F 
Sbjct: 85  VYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFK 144

Query: 147 LEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKTEYL 206
              G+ EDGKG+CP+DPA  +  ++VDGELYS T  NFLG+EPII RN   H  ++TEY 
Sbjct: 145 FL-GKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSS-HSPLRTEYA 202

Query: 207 AFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMG 266
             WLNEP FV +  + +S  S  G+DD+VYFFF E +VE +     ++ R+ARVCKGD G
Sbjct: 203 IPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQG 262

Query: 267 GARTLQRKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYL 326
           G RTLQ+KWT+FLKARL CS P+  L FN L+ +  L+        F+ +F  Q  ++ L
Sbjct: 263 GLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGL 322

Query: 327 SAICEYQLEEIQRVF-EGPYKE---YHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTS 382
           SA+C Y L   + VF  G Y +     +   KW RY  PVP PRPG+CI++  R   YTS
Sbjct: 323 SAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTS 382

Query: 383 SLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIG 442
           SL LPD  L FVK HPLM++ V P  +RP L+KK  N+T +V DR   LDG  Y V+F+ 
Sbjct: 383 SLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVS 442

Query: 443 TGDGWLLKAVSLGPWVHLIEELQLF-DQEPMRSLVLSQSK--KLLFAGSRSQLVQLPVAD 499
           T  G L KA+SL   VH+IEE QLF D EP+++L+LS  K  + ++AGS S +VQ P+A 
Sbjct: 443 TDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAF 502

Query: 500 CMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLLIQHVMTSDTSG-ICNLRGSKKV 558
           C K+ +C DCVLARDPYCAWS  T+ CVA+          H   S + G I  + G   V
Sbjct: 503 CGKHGTCEDCVLARDPYCAWSPPTATCVAL----------HQTESPSRGLIQEMSGDASV 552

Query: 559 RP--TPKNITVVAGTDLVLPCHLSSNLAHARWT 589
            P  +PK +     + L    H+      + WT
Sbjct: 553 CPASSPKPLPPPGSSSLSCLGHVGDRRLSSPWT 585


>gi|19923279 semaphorin W [Homo sapiens]
          Length = 770

 Score =  408 bits (1048), Expect = e-113
 Identities = 274/761 (36%), Positives = 392/761 (51%), Gaps = 49/761 (6%)

Query: 28  VPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSME-ALELQGA 86
           VPR ++   E  + + RF+     ++  L +   +  LYVGAR+ +FA S+  + E    
Sbjct: 40  VPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRR 99

Query: 87  ISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNMLTFT 146
           I W  P   +  C +KGK  + EC NF++ L   NASHL  CGT+AF PKC  +++  F 
Sbjct: 100 IDWMVPEAHRQNCRKKGKK-EDECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQ 158

Query: 147 LEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHS-MKTEY 205
            +    E G+GKCP++PA+  A ++  G LY+AT+ N+LGTEPII R +G     ++T+ 
Sbjct: 159 -QVERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDT 217

Query: 206 LAFWLNEPHFVGS-AYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGD 264
           L  WLN P FV + A  P   G   GDD+ +YFFF E +   D Y    V RVARVC GD
Sbjct: 218 LPSWLNAPAFVAAVALSPAEWGDEDGDDE-IYFFFTETSRAFDSYERIKVPRVARVCAGD 276

Query: 265 MGGARTLQRKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDTSWHNTT-FFGVFQAQWGD 323
           +GG +TLQ++WTTFLKA L C  P      + LQ +  L+      T  F+G+F +QW  
Sbjct: 277 LGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEG 336

Query: 324 MYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTD-PVPSPRPGSCINNWHRRHGYTS 382
             +SA+C ++ ++I+ V  GP++E   +  +     D  VP PRPG CI N  +   + S
Sbjct: 337 ATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGS 396

Query: 383 SLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIG 442
           SL LPD +L F++ HPLM+  V P    PLLV   T +  +VA RVT L G  Y VL++G
Sbjct: 397 SLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLG 456

Query: 443 TGDGWLLKAVSLGPWVHLIEELQLF-DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCM 501
           T DG L +AV +G  + ++E+L LF + +P+ ++ L  S   L  GSR+++ Q+   +C 
Sbjct: 457 TEDGHLHRAVRIGAQLSVLEDLALFPEPQPVENMKLYHS--WLLVGSRTEVTQVNTTNCG 514

Query: 502 KYRSCADCVLARDPYCAWSVNTSRCVA-VGGHSGSLLIQHVMTSDTSGICNLRGSKKVRP 560
           + +SC++C+LA+DP CAWS     CVA  G H G  L+Q + ++D S +C     +  RP
Sbjct: 515 RLQSCSECILAQDPVCAWSFRLDECVAHAGEHRG--LVQDIESADVSSLCPKEPGE--RP 570

Query: 561 TPKNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQP-GSFLYDARLQALVVMAAQP 619
               + V     +VLPC  SS  A   W          QP G      R   L V+   P
Sbjct: 571 VVFEVPVATAAHVVLPCSPSSAWASCVW---------HQPSGVTALTPRRDGLEVVVT-P 620

Query: 620 RHAGAYHCFSEEQGARLAAEGYLVAVVAGPSVTLEARAPLENLGLVWLAVVALGAVCLVL 679
              GAY C  +E GA      Y  ++V G      +RA     GL    +  L A   ++
Sbjct: 621 GAMGAYACECQEGGAAHVVAAY--SLVWGSQRDAPSRAHTVGAGLAGFFLGILAASLTLI 678

Query: 680 LLLVLSLRRRLREELEKGAKATERTLVYPLELPKEPTSPPFRPCPEPDEKLWDPVGYYYS 739
           L+     RRR RE L +     +  L  P       +  P  P PE DE+L  P+     
Sbjct: 679 LIGRRQQRRRQRELLARDKVGLD--LGAPPSGTTSYSQDPPSPSPE-DERL--PLAL--- 730

Query: 740 DGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGG 780
                     A+   G G  SPP  +   P PSP  + L G
Sbjct: 731 ----------AKRGSGFGGFSPPFLL--DPCPSPAHIRLTG 759


>gi|21361914 semaphorin B [Homo sapiens]
          Length = 761

 Score =  401 bits (1030), Expect = e-111
 Identities = 246/633 (38%), Positives = 343/633 (54%), Gaps = 48/633 (7%)

Query: 28  VPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSME---ALELQ 84
           +PR    +G+    +  F Q G+QDF TL L+     LYVGAREA+ A  ++      L+
Sbjct: 39  MPRVRYYAGDERRALSFFHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLK 98

Query: 85  GAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNM-- 142
             I W A   KK+EC  K K+N+T+CFNFIR L  YN +HLY CGT+AF P CT++ +  
Sbjct: 99  NMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQD 158

Query: 143 -LTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSM 201
                +   +  +GKG+ P+DPA  H  +LVDG LYS T+NNFLG+EPI++R +G    +
Sbjct: 159 SYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVL 218

Query: 202 KTEYLAFWL-NEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARV 260
           KT+    WL ++  FV  A +P +          VYFFF E A E D +     +RVARV
Sbjct: 219 KTDNFLRWLHHDASFV--AAIPST--------QVVYFFFEETASEFDFFERLHTSRVARV 268

Query: 261 CKGDMGGARTLQRKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQ 320
           CK D+GG + LQ+KWTTFLKA+L C+ P  QL FN ++    L   S      + VF +Q
Sbjct: 269 CKNDVGGEKLLQKKWTTFLKAQLLCTQPG-QLPFNVIRHAVLLPADSPTAPHIYAVFTSQ 327

Query: 321 W--GDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRH 378
           W  G    SA+C + L +I+RVF+G YKE ++E  +W  Y  P  +PRPGSC        
Sbjct: 328 WQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPETNPRPGSC-------- 379

Query: 379 GYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTV 438
              S     D  L F+K H LM+EQV      PLLVK G  +T L  +   GLDG ++ V
Sbjct: 380 ---SVGPSSDKALTFMKDHFLMDEQV---VGTPLLVKSGVEYTRLAVETAQGLDGHSHLV 433

Query: 439 LFIGTGDGWLLKAVSLG-PWVHLIEELQLF-DQEPMRSLVLSQSKKLLFAGSRSQLVQLP 496
           +++GT  G L KAV  G    HL+EE+QLF D EP+R+L L+ ++  +F G    + ++P
Sbjct: 434 MYLGTTTGSLHKAVVSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVP 493

Query: 497 VADCMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLLIQHVMTSDTSGIC-NLRGS 555
            A+C  Y SC DCVLARDP+CAW   +  C  +   + +   Q +   +    C +   S
Sbjct: 494 RANCSVYESCVDCVLARDPHCAWDPESRTCCLLSAPNLNSWKQDMERGNPEWACASGPMS 553

Query: 556 KKVRPTP-----KNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLYDARLQ 610
           + +RP       K +  V  + L LPC   S LA   W+ G   +P  +  S +Y+  L 
Sbjct: 554 RSLRPQSRPQIIKEVLAVPNSILELPCPHLSALASYYWSHGPAAVP--EASSTVYNGSLL 611

Query: 611 ALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLV 643
            +V    Q    G Y C++ E G       Y V
Sbjct: 612 LIV----QDGVGGLYQCWATENGFSYPVISYWV 640


>gi|5174673 semaphorin 3A precursor [Homo sapiens]
          Length = 771

 Score =  355 bits (910), Expect = 1e-97
 Identities = 235/667 (35%), Positives = 343/667 (51%), Gaps = 55/667 (8%)

Query: 8   WL--LAARLWGLGIGAEVWW----NLVPRKTVSSGELATVVRRFSQTGIQD---FLTLTL 58
           WL  +    WG+ + A   +    N VPR  +S  E+       +  G+ +   + T  L
Sbjct: 3   WLTRIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLL 62

Query: 59  TEPTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQ 118
            E    LYVGA++ +F+F +  ++    I W     ++ EC   GK+   EC NFI+ L+
Sbjct: 63  DEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLK 122

Query: 119 PYNASHLYVCGTYAFQPKCTYVNM------LTFTLEHGEFEDGKGKCPYDPAKGHAGLLV 172
            YN +HLY CGT AF P CTY+ +        F LE+  FE+G+GK PYDP    A LL+
Sbjct: 123 AYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLI 182

Query: 173 DGELYSATLNNFLGTEPIILRNMGPHHSMKTE-YLAFWLNEPHFVGSAYVPESVGSFTGD 231
           DGELYS T  +F+G +  I R +G HH ++TE + + WLN+P F+ +  + ES      +
Sbjct: 183 DGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNP---E 239

Query: 232 DDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAP--- 288
           DDKVYFFFRE A++ +   +   AR+ ++CK D GG R+L  KWTTFLKARL CS P   
Sbjct: 240 DDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPN 299

Query: 289 NWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEY 348
               +F++LQ +  +      N   +GVF         SA+C Y + +++RVF GPY   
Sbjct: 300 GIDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHR 359

Query: 349 HEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRW 408
                +W  Y   VP PRPG+C +      G+ S+ +LPD+++ F + HP M   V P  
Sbjct: 360 DGPNYQWVPYQGRVPYPRPGTCPSKTF--GGFDSTKDLPDDVITFARSHPAMYNPVFPMN 417

Query: 409 SRPLLVKKGTN--FTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSL--GPWVH----L 460
           +RP+++K   N  FT +V DRV   DG  Y V+FIGT  G +LK VS+    W      L
Sbjct: 418 NRPIVIKTDVNYQFTQIVVDRVDAEDG-QYDVMFIGTDVGTVLKVVSIPKETWYDLEEVL 476

Query: 461 IEELQLFDQEP--MRSLVLSQSKKLLFAGSRSQLVQLPVADCMKY-RSCADCVLARDPYC 517
           +EE+ +F +EP  + ++ LS  ++ L+ GS + + QLP+  C  Y ++CA+C LARDPYC
Sbjct: 477 LEEMTVF-REPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYC 535

Query: 518 AWSVNT-SRCVAVGGHSGSLLIQHVMTSDTSGIC------NLRGSKKVRPTPKNITVVAG 570
           AW  +  SR             Q +   D    C      N  G     P  + I  V  
Sbjct: 536 AWDGSACSRYFPTAKRRTRR--QDIRNGDPLTHCSDLHHDNHHGHS---PEERIIYGVEN 590

Query: 571 TDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLYDARL----QALVVMAAQPRHAGAYH 626
           +   L C   S  A   W F  R+   E+      D  +    Q L++ + Q + +G Y 
Sbjct: 591 SSTFLECSPKSQRALVYWQFQRRN--EERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYL 648

Query: 627 CFSEEQG 633
           C + E G
Sbjct: 649 CHAVEHG 655


>gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]
          Length = 749

 Score =  348 bits (892), Expect = 2e-95
 Identities = 230/650 (35%), Positives = 329/650 (50%), Gaps = 41/650 (6%)

Query: 12  ARLWGLGIGAEVWWNLVPRKTVSSGELATV--VRRFSQTGIQDFLTLTLTEPTGLLYVGA 69
           A LW +G+G+       PR  +S  EL     ++ FS      +  L + E  G L+VGA
Sbjct: 14  ALLWAVGLGSAA--PSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFVGA 71

Query: 70  REALFAFSMEALELQGA-ISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVC 128
              + + +++ +  +   ++W APVE + EC   GK+  TEC NF++ L  YN +HL  C
Sbjct: 72  ENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLAC 131

Query: 129 GTYAFQPKCTYVNM------LTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLN 182
           GT AF P C +V +          L+ G  EDGKGK PYDP    A +LV  ELYS    
Sbjct: 132 GTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGVAA 191

Query: 183 NFLGTEPIILRNMGPHHSMKTE-YLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRE 241
           + +G +  I R++G   S++TE + + WLNEP FV   ++PES      DDDK+YFFFRE
Sbjct: 192 DLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENP---DDDKIYFFFRE 248

Query: 242 RAVE-SDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAPNWQ--LYFNQLQ 298
            AVE +       V+RV ++C+ D+GG R+L  KWTTFLKARL CS P  +   +F+QLQ
Sbjct: 249 TAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQ 308

Query: 299 AMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRY 358
            +  L          + VF         SA+C Y + +++R F GP+        +W  Y
Sbjct: 309 DVFLLSSRDHRTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSY 368

Query: 359 TDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGT 418
              VP PRPG C +       ++S+ + PD+++ F + HPLM   V P   RPL ++ G 
Sbjct: 369 QGRVPYPRPGMCPSKTFGT--FSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGA 426

Query: 419 N--FTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLGPWVH------LIEELQLF-DQ 469
           N  FT + ADRV   DG  Y VLFIGT  G +LK +S+           L+EEL +F D 
Sbjct: 427 NYTFTQIAADRVAAADG-HYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFEDS 485

Query: 470 EPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKY-RSCADCVLARDPYCAW-SVNTSRCV 527
             + S+ +S  +  L+  SRS + Q+ +  C  + R C +C LARDPYCAW  V  +R  
Sbjct: 486 AAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRFQ 545

Query: 528 AVGGHSGSLLIQHVMTSDTSGICNLRGSKKVRPTPKNITVVAGTDLVLPCHLSSNLAHAR 587
                      Q V   D S +C+   S+      K +  V G+   L C   S  A   
Sbjct: 546 P--SAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHK-VFGVEGSSAFLECEPRSLQARVE 602

Query: 588 WTFGGRDLPAEQPGSFLYDARLQ----ALVVMAAQPRHAGAYHCFSEEQG 633
           WTF    + A      L + R +     L++   + R +G Y C + EQG
Sbjct: 603 WTFQRAGVTAHT--QVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQG 650


>gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]
          Length = 748

 Score =  344 bits (883), Expect = 2e-94
 Identities = 230/650 (35%), Positives = 329/650 (50%), Gaps = 42/650 (6%)

Query: 12  ARLWGLGIGAEVWWNLVPRKTVSSGELATV--VRRFSQTGIQDFLTLTLTEPTGLLYVGA 69
           A LW +G+G+       PR  +S  EL     ++ FS      +  L + E  G L+VGA
Sbjct: 14  ALLWAVGLGSAA--PSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFVGA 71

Query: 70  REALFAFSMEALELQGA-ISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVC 128
              + + +++ +  +   ++W APVE + EC   GK+  TEC NF++ L  YN +HL  C
Sbjct: 72  ENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLAC 131

Query: 129 GTYAFQPKCTYVNM------LTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLN 182
           GT AF P C +V +          L+ G  EDGKGK PYDP    A +LV  ELYS    
Sbjct: 132 GTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGVAA 191

Query: 183 NFLGTEPIILRNMGPHHSMKTE-YLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRE 241
           + +G +  I R++G   S++TE + + WLNEP FV   ++PES      DDDK+YFFFRE
Sbjct: 192 DLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENP---DDDKIYFFFRE 248

Query: 242 RAVE-SDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAPNWQ--LYFNQLQ 298
            AVE +       V+RV ++C+ D+GG R+L  KWTTFLKARL CS P  +   +F+QLQ
Sbjct: 249 TAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQ 308

Query: 299 AMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRY 358
            +  L          + VF         SA+C Y + +++R F GP+        +W  Y
Sbjct: 309 DVFLLSSRDHRTPLLYAVFSTS-SIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSY 367

Query: 359 TDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGT 418
              VP PRPG C +       ++S+ + PD+++ F + HPLM   V P   RPL ++ G 
Sbjct: 368 QGRVPYPRPGMCPSKTFGT--FSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGA 425

Query: 419 N--FTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLGPWVH------LIEELQLF-DQ 469
           N  FT + ADRV   DG  Y VLFIGT  G +LK +S+           L+EEL +F D 
Sbjct: 426 NYTFTQIAADRVAAADG-HYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFEDS 484

Query: 470 EPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKY-RSCADCVLARDPYCAW-SVNTSRCV 527
             + S+ +S  +  L+  SRS + Q+ +  C  + R C +C LARDPYCAW  V  +R  
Sbjct: 485 AAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRFQ 544

Query: 528 AVGGHSGSLLIQHVMTSDTSGICNLRGSKKVRPTPKNITVVAGTDLVLPCHLSSNLAHAR 587
                      Q V   D S +C+   S+      K +  V G+   L C   S  A   
Sbjct: 545 P--SAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHK-VFGVEGSSAFLECEPRSLQARVE 601

Query: 588 WTFGGRDLPAEQPGSFLYDARLQ----ALVVMAAQPRHAGAYHCFSEEQG 633
           WTF    + A      L + R +     L++   + R +G Y C + EQG
Sbjct: 602 WTFQRAGVTAHT--QVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQG 649


>gi|41406086 semaphorin 3D [Homo sapiens]
          Length = 777

 Score =  338 bits (868), Expect = 9e-93
 Identities = 193/494 (39%), Positives = 281/494 (56%), Gaps = 28/494 (5%)

Query: 52  DFLTLTLTEPTGLLYVGAREALFAFSMEALELQ-GAISWEAPVEKKTECIQKGKNNQTEC 110
           DF TL L E  G L +GA++ +F  S+  L      I W A  E+   C   GK+  TEC
Sbjct: 69  DFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTEC 128

Query: 111 FNFIRFLQPYNASHLYVCGTYAFQPKCTYVNM------LTFTLEHGEFEDGKGKCPYDPA 164
            NFIR LQPYN +H+YVCGT AF P C Y+++      + F L+    E G+ KCP+DP 
Sbjct: 129 ANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQ 188

Query: 165 KGHAGLLVDGELYSATLNNFLGTEPIILRNMGP---HHSMKTEYLA-FWLNEPHFVGSAY 220
           +  A ++ D  LYS T ++FLG +    R++GP   HH ++T+    +WLN   F+G+ +
Sbjct: 189 QPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFF 248

Query: 221 VPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLK 280
           +P++   +  DDDK+YFFFRE + E     + +++RV RVCK D+GG R+L  KWTTFLK
Sbjct: 249 IPDT---YNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLK 305

Query: 281 ARLACSAP---NWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEI 337
           ARL CS P       YF++LQ ++ L      N   +GVF         SA+C Y + +I
Sbjct: 306 ARLICSIPGSDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADI 365

Query: 338 QRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKH 397
           + VF GPY        +W +Y   +P PRPG+C +  +      S+ + PD++++F+K+H
Sbjct: 366 RAVFNGPYAHKESADHRWVQYDGRIPYPRPGTCPSKTYDPL-IKSTRDFPDDVISFIKRH 424

Query: 398 PLMEEQVGPRWSRPLLVKKGTNF--THLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLG 455
            +M + V P    P   +   ++  T +V D V   DG  Y V+F+GT  G +LK VS+ 
Sbjct: 425 SVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDG-QYDVMFLGTDIGTVLKVVSIS 483

Query: 456 --PW---VHLIEELQLFDQEP-MRSLVLSQSKKLLFAGSRSQLVQLPVADCMKY-RSCAD 508
              W     ++EELQ+F     + ++ LS  ++ L+ GSR  LVQL +  C  Y ++CAD
Sbjct: 484 KEKWNMEEVVLEELQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACAD 543

Query: 509 CVLARDPYCAWSVN 522
           C LARDPYCAW  N
Sbjct: 544 CCLARDPYCAWDGN 557


>gi|9910362 semaphorin sem2 [Homo sapiens]
          Length = 782

 Score =  319 bits (818), Expect = 6e-87
 Identities = 231/690 (33%), Positives = 335/690 (48%), Gaps = 57/690 (8%)

Query: 1   MAPH-WAV-WLLAARLWGLGIGAEVWWNLVPRKTVSSGELATVVRRFSQTGIQDFLTLT- 57
           MAP  WA+ WLL   L   G         VPR  +S  +L +  R     G Q  L L  
Sbjct: 1   MAPSAWAICWLLGGLLLHGGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQA 60

Query: 58  --LTEPTGLLYVGAREALFAFSME-ALELQGAISWEAPVEKKTECIQKGKNNQTECFNFI 114
             L E    L++G  +AL++  ++ A      + W     ++ EC++KG++  TEC NF+
Sbjct: 61  MYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFV 120

Query: 115 RFLQPYNASHLYVCGTYAFQPKCTYVNM-----LTFTLEHGEFEDGKGKCPYDPAKGHAG 169
           R LQP+N +HL  CGT AFQP C  + +         LE G  E G+G+CP++P++  A 
Sbjct: 121 RVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFAS 180

Query: 170 LLVDGELYSATLNNFLGTEPIILRNMGPHHSMKTEYLAFWLNEPHFVGSAYVPESVGSFT 229
             +DGELY+    +FLG E +I R+ GP  +++++     L++P FV +A +PE+     
Sbjct: 181 TFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMAARIPENSDQ-- 238

Query: 230 GDDDKVYFFFRERAVESDCYAEQV-VARVARVCKGDMGGARTLQRKWTTFLKARLACSAP 288
            D+DKVYFFF E     D  +  V V+RV RVC  D GG R L  KW+TFLKARL CS P
Sbjct: 239 -DNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVP 297

Query: 289 ---NWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPY 345
                + +F+QL+ +  L   +  +   + +F          A+C Y + +I  VF GP+
Sbjct: 298 GPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVFNGPF 357

Query: 346 KEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHG--YTSSLELPDNILNFVKKHPLMEEQ 403
                   +W  Y   VP PRPG C +    + G  + S+ + PD +L F + HPLM   
Sbjct: 358 AHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWP 417

Query: 404 VGPRWSRPLLVKK--GTNFTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSL------G 455
           V PR  RP+LVK         +V DRV   DG TY V+F+GT  G +LK ++L       
Sbjct: 418 VRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDG-TYDVIFLGTDSGSVLKVIALQAGGSAE 476

Query: 456 PWVHLIEELQLFD-QEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKY-RSCADCVLAR 513
           P   ++EELQ+F    P+  + +S  +++L+ GSR  + QL +  C  Y  +CA+C LAR
Sbjct: 477 PEEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLAR 536

Query: 514 DPYCAW----------SVNTSRCVAVGGHSGSLLIQHVMTSDTSGICNLRGSKKVRPTPK 563
           DPYCAW          S+   R        G+  +Q +  S       L  +  V  T  
Sbjct: 537 DPYCAWDGASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVGLVAATMVYGTEH 596

Query: 564 NITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQ-PGSFLYDARL----QALVVMAAQ 618
           N T        L C   S  A  RW       P ++ P     D R+    + L+     
Sbjct: 597 NST-------FLECLPKSPQAAVRWLL---QRPGDEGPDQVKTDERVLHTERGLLFRRLS 646

Query: 619 PRHAGAYHCFSEEQG-ARLAAEGYLVAVVA 647
              AG Y C + E G ++      LV +VA
Sbjct: 647 RFDAGTYTCTTLEHGFSQTVVRLALVVIVA 676


>gi|6912650 semaphorin 3E [Homo sapiens]
          Length = 775

 Score =  315 bits (807), Expect = 1e-85
 Identities = 198/554 (35%), Positives = 285/554 (51%), Gaps = 35/554 (6%)

Query: 9   LLAARLWG----LGIGAEVWWNLVPRKTVSSGELATVVRR---FSQTGIQDFLTLTLTEP 61
           ++   LWG    L  G        PR  +S  EL  + R     S  G  D  T+ L E 
Sbjct: 7   IITLLLWGYLLELWTGGHTADTTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEY 66

Query: 62  TGLLYVGAREALFAFSMEAL-ELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPY 120
              L+VG R+ +++ S+E + +    I W +   K  ECI KGK+   EC N++R L  Y
Sbjct: 67  QERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKD-AGECANYVRVLHHY 125

Query: 121 NASHLYVCGTYAFQPKCTYVNM------LTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDG 174
           N +HL  CGT AF P C ++ +        F LE    E G+G+CP+DP+      L+  
Sbjct: 126 NRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGS 185

Query: 175 ELYSATLNNFLGTEPIILRNMGPHHSMKTEYL-AFWLNEPHFVGSAYVPESVGSFTGDDD 233
           EL++   +++   +  I R+MG    ++TE+     L EP FVGS  +P++      DD+
Sbjct: 186 ELFAGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDR---DDN 242

Query: 234 KVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAPNW--- 290
           KVYFFF E+A+E++  A  +  RV R+C  D+GG R L  KW+TFLKARL CS P     
Sbjct: 243 KVYFFFTEKALEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGI 302

Query: 291 QLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHE 350
             YF++L+ +  L      N   FG+F          AIC Y +  I+  F GPY     
Sbjct: 303 DTYFDELEDVFLLPTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEG 362

Query: 351 EAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSR 410
               W  Y   VP PRPGSC +  +    Y ++ + PD+ + F + HPLM + + P   +
Sbjct: 363 PEYHWSVYEGKVPYPRPGSCASKVNGGR-YGTTKDYPDDAIRFARSHPLMYQAIKPAHKK 421

Query: 411 PLLVKKG--TNFTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSL------GPWVHLIE 462
           P+LVK     N   +  DRV   DG  Y VLFIGT +G +LK +++           ++E
Sbjct: 422 PILVKTDGKYNLKQIAVDRVEAEDG-QYDVLFIGTDNGIVLKVITIYNQEMESMEEVILE 480

Query: 463 ELQLF-DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKYRS-CADCVLARDPYCAW- 519
           ELQ+F D  P+ S+ +S  ++ L+ GS S + Q+    C  Y S CADC LARDPYCAW 
Sbjct: 481 ELQIFKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWD 540

Query: 520 SVNTSRCVAVGGHS 533
            ++ SR    G H+
Sbjct: 541 GISCSRYYPTGTHA 554


>gi|188497703 semaphorin 3F [Homo sapiens]
          Length = 785

 Score =  313 bits (801), Expect = 5e-85
 Identities = 207/637 (32%), Positives = 305/637 (47%), Gaps = 67/637 (10%)

Query: 52  DFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAI-SWEAPVEKKTECIQKGKNNQTEC 110
           D+  L   E    +YVG+++ + +  +  +  +  I  W A  ++  EC+  GK+   EC
Sbjct: 56  DYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGEC 115

Query: 111 FNFIRFLQPYNASHLYVCGTYAFQPKCTYVNM---------------------------- 142
            NF+R +QP+N +HLYVCGT A+ P CTYVN                             
Sbjct: 116 GNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALR 175

Query: 143 ---------LTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILR 193
                      F LE    E GKGKCPYDP    A  L++ ELY+    +F+GT+  I R
Sbjct: 176 PMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFR 235

Query: 194 NMGPHHSMKT-EYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQ 252
            +G   +M+T +Y + WLN+P F+ +  +P+S      +DDK+YFFFRER+ E+   +  
Sbjct: 236 TLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSA---ERNDDKLYFFFRERSAEAP-QSPA 291

Query: 253 VVARVARVCKGDMGGARTLQRKWTTFLKARLACSAP---NWQLYFNQLQAMHTLQDTSWH 309
           V AR+ R+C  D GG   L  KW+TFLKARL CS P     + +F++LQ +   Q     
Sbjct: 292 VYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVR 351

Query: 310 NTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGS 369
           N   + VF +       SA+C Y + +I+ VF GP+        +W  ++  +P PRPG+
Sbjct: 352 NPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGT 411

Query: 370 CINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNF--THLVADR 427
           C           S+ + PD ++NF++ HPLM + V P   RPL+V+ G  +  T +  D+
Sbjct: 412 CPGGTF-TPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQ 470

Query: 428 VTGLDGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQE------PMRSLVLSQSK 481
           V   DG  Y VLF+GT  G + K + L      +EEL L + E      P++++ +S  +
Sbjct: 471 VDAADG-RYEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKR 529

Query: 482 KLLFAGSRSQLVQLPVADCMKY-RSCADCVLARDPYCAWSVNT-SRCVAVGGHSGSLLIQ 539
           + L+  S   +  L +  C  Y  +CADC LARDPYCAW     SR  A          Q
Sbjct: 530 QQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRR--Q 587

Query: 540 HVMTSDTSGICNLRGSKKVRPTPKNITV-VAGTDLVLPCHLSSNLAHARWTF----GGRD 594
            V   +    C    S   +   +++   VAG+   L C   S  A  +W F    G R 
Sbjct: 588 DVRHGNPIRQCRGFNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRR 647

Query: 595 LPAEQPGSFLYDARLQALVVMAAQPRHAGAYHCFSEE 631
                   FL     Q L++ A Q    G Y C + E
Sbjct: 648 REIRAEDRFLRTE--QGLLLRALQLSDRGLYSCTATE 682


>gi|5454048 semaphorin 3C [Homo sapiens]
          Length = 751

 Score =  300 bits (767), Expect = 5e-81
 Identities = 190/603 (31%), Positives = 309/603 (51%), Gaps = 31/603 (5%)

Query: 52  DFLTLTLTEPTGLLYVGAREALFAFSMEALELQG-AISWEAPVEKKTECIQKGKNNQTEC 110
           D+  L + E    +YVG+++ + + ++  +  +  ++ W A   K  EC   GK+    C
Sbjct: 53  DYRILLMDEDQDRIYVGSKDHILSLNINNISQEALSVFWPASTIKVEECKMAGKDPTHGC 112

Query: 111 FNFIRFLQPYNASHLYVCGTYAFQPKCTYVNM------LTFTLEHGEFEDGKGKCPYDPA 164
            NF+R +Q +N +HLYVCG+ AF P CTY+N         F ++  + E GKG+C ++P 
Sbjct: 113 GNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRRSEDQVFMID-SKCESGKGRCSFNPN 171

Query: 165 KGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKTE-YLAFWLNEPHFVGSAYVPE 223
                ++++ EL+S    +F+GT+  I R++   ++++T+ + + WL+EP FV +  +P+
Sbjct: 172 VNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDAHVIPD 231

Query: 224 SVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARL 283
                  +D KVYFFF+E+  +++   +Q+ + +AR+C  D GG R+L  KWTTFLKARL
Sbjct: 232 GTDP---NDAKVYFFFKEKLTDNNRSTKQIHSMIARICPNDTGGLRSLVNKWTTFLKARL 288

Query: 284 ACSAPNW---QLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRV 340
            CS  +    + +F++L+ +  L+  +   T  +G+F         SA+C Y L +IQ V
Sbjct: 289 VCSVTDEDGPETHFDELEDVFLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLSDIQTV 348

Query: 341 FEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLM 400
           F GP+        +   Y   +P PRPG+C       +  T+  E PD+++ F++ HPLM
Sbjct: 349 FNGPFAHKEGPNHQLISYQGRIPYPRPGTCPGGAFTPNMRTTK-EFPDDVVTFIRNHPLM 407

Query: 401 EEQVGPRWSRPLLVKKGTN--FTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLG--- 455
              + P   RPL+V+ GT+  +T +  DRV   DG  Y VLF+GT  G + K V L    
Sbjct: 408 YNSIYPIHKRPLIVRIGTDYKYTKIAVDRVNAADG-RYHVLFLGTDRGTVQKVVVLPTNN 466

Query: 456 --PWVHLIEELQLF-DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKY-RSCADCVL 511
                 ++EEL++F +  P+ ++ +S  K+ L+  S   + Q+ +  C  Y  +CADC L
Sbjct: 467 SVSGELILEELEVFKNHAPITTMKISSKKQQLYVSSNEGVSQVSLHRCHIYGTACADCCL 526

Query: 512 ARDPYCAWSVNT-SRCVAVGGHSGSLLIQHVMTSDTSGICNLRGSKKVRPTPKNITV-VA 569
           ARDPYCAW  ++ SR    G        Q V   +    C     K  R   + +   V 
Sbjct: 527 ARDPYCAWDGHSCSRFYPTGKRRSRR--QDVRHGNPLTQCRGFNLKAYRNAAEIVQYGVK 584

Query: 570 GTDLVLPCHLSSNLAHARWTF-GGRDLPAEQPGSFLYDARLQALVVMAAQPRHAGAYHCF 628
                L C   S  A  +W     +D   E   +    A  Q L++ + Q    G YHC 
Sbjct: 585 NNTTFLECAPKSPQASIKWLLQKDKDRRKEVKLNERIIATSQGLLIRSVQGSDQGLYHCI 644

Query: 629 SEE 631
           + E
Sbjct: 645 ATE 647


>gi|147904700 semaphorin 5A [Homo sapiens]
          Length = 1074

 Score =  274 bits (700), Expect = 3e-73
 Identities = 177/506 (34%), Positives = 257/506 (50%), Gaps = 36/506 (7%)

Query: 33  VSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEAP 92
           +S  E+   +R F      DF  LT       L VGAR  LF   +E L L  A+ WE  
Sbjct: 38  ISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECD 97

Query: 93  VEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNMLTFTLEHGEF 152
              K  C  KGK+ + EC N+IR L       L+ CGT AF P CT  ++   T  H + 
Sbjct: 98  EATKKACYSKGKSKE-ECQNYIRVLL-VGGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQI 155

Query: 153 EDGKGKCPYDPAKGHAGLLV-DGELYSATLNNFLGTEPIILRNMGPHHSMKT-EYLAFWL 210
             G  +CPY P      LL   GELY+AT  +F G +P I R++G    ++T +Y + WL
Sbjct: 156 S-GMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWL 214

Query: 211 NEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGART 270
           NEP+FV S      +G+FT      YFFFRE AVE DC  + V +R ARVCK D+GG   
Sbjct: 215 NEPNFVSSY----DIGNFT------YFFFRENAVEHDC-GKTVFSRAARVCKNDIGGRFL 263

Query: 271 LQRKWTTFLKARLACSAPNW-QLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAI 329
           L+  WTTF+KARL CS P     Y+N+LQ+   L +        +G+F      +  SA+
Sbjct: 264 LEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELD----LIYGIFTTNVNSIAASAV 319

Query: 330 CEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDN 389
           C + L  I + F GP+K        W  Y +P P  + G+     +        + L + 
Sbjct: 320 CVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQGLY--------VNLTER 371

Query: 390 ILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIGTGDGWLL 449
            L   +K  LM E V P  + P  ++  + F+H+  D V G +   + ++++ T  G + 
Sbjct: 372 NLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVH-IIYLATDYGTIK 430

Query: 450 KA-VSLGPWVH--LIEELQLFDQ---EPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKY 503
           K  V L       L+EE++LF +   EP+RSL +  S+ +LF G R  +V++P+  C  Y
Sbjct: 431 KVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFY 490

Query: 504 RSCADCVLARDPYCAWSVNTSRCVAV 529
           R+ + C+ A+DPYC W V   +C ++
Sbjct: 491 RTRSTCIGAQDPYCGWDVVMKKCTSL 516


>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
          Length = 1151

 Score =  270 bits (691), Expect = 3e-72
 Identities = 198/596 (33%), Positives = 285/596 (47%), Gaps = 70/596 (11%)

Query: 32  TVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEA 91
           TV+  +L   V  F+  G +DF  L L      L VGAR  LF  S+  + L  A  W +
Sbjct: 105 TVAFEDLQPWVSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQATEWAS 164

Query: 92  PVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCT--YVNMLTFTLEH 149
             + +  C  KGK  + EC N++R L       +++CGT AF P CT   V  L+ T+E 
Sbjct: 165 SEDTRRSCQSKGKTEE-ECQNYVRVLIVAGRK-VFMCGTNAFSPMCTSRQVGNLSRTIEK 222

Query: 150 GEFEDGKGKCPYDPAKGHAGLLVD-GELYSATLNNFLGTEPIILRNMGPHHSMKT-EYLA 207
               +G  +CPYDP      ++   GELY+AT+ +F G +P I R++G    ++T +Y +
Sbjct: 223 ---INGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNS 279

Query: 208 FWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGG 267
            WLNEP+FV +AY    +G F       YFF RE AVE DC    V +RVARVCK D+GG
Sbjct: 280 KWLNEPNFV-AAY---DIGLFA------YFFLRENAVEHDC-GRTVYSRVARVCKNDVGG 328

Query: 268 ARTLQRKWTTFLKARLACSAPNW-QLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYL 326
              L+  WTTF+KARL CS P     Y+N+LQ+   L +        +GVF      +  
Sbjct: 329 RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQD----LIYGVFTTNVNSIAA 384

Query: 327 SAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLEL 386
           SA+C + L  I + F GP++        W    +P+P+ + G+        +       L
Sbjct: 385 SAVCAFNLSAISQAFNGPFRYQENPRAAWLPIANPIPNFQCGTLPETGPNEN-------L 437

Query: 387 PDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIGTGDG 446
            +  L   ++  LM E V P    P + +    F+HLV D V   D   Y VL+IGT  G
Sbjct: 438 TERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKD-TLYHVLYIGTESG 496

Query: 447 WLLKAVSLGPW-VH--LIEELQLFD---QEPMRSLVLSQSKKLLFAGSRSQLVQLPVADC 500
            +LKA+S     +H   +EEL +     +EP+RSL +  S + LF G R  ++++P+  C
Sbjct: 497 TILKALSTASRSLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERC 556

Query: 501 MKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSG-SLLIQHV------------------ 541
             YRS   C+ ARDPYC W     RC  +   S  SL  Q++                  
Sbjct: 557 AAYRSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNITACPVRNVTRDGGFGPWS 616

Query: 542 -------MTSDTSGICNLRGSKKVRPTPKNITVVAGTDLVLPC-HLSSNLAHARWT 589
                  +  D SG C  R      P P+      G D + P  H+++   +  WT
Sbjct: 617 PWQPCEHLDGDNSGSCLCRARSCDSPRPR----CGGLDCLGPAIHIANCSRNGAWT 668


>gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]
          Length = 1011

 Score =  268 bits (685), Expect = 2e-71
 Identities = 166/487 (34%), Positives = 259/487 (53%), Gaps = 52/487 (10%)

Query: 65  LYVGAREALFAFSMEALELQGAI-----SWEAPVEKKTECIQKGKNNQTECFNFIRFLQP 119
           LY+  R+ ++  ++  +     I     +W +  + +  C  KGK+   EC NFI+   P
Sbjct: 69  LYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECHNFIKVFVP 127

Query: 120 YNASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSA 179
            N   ++VCGT AF P C Y  + T   + GE   G  +CP+D  + +  L  DG+LYSA
Sbjct: 128 RNDEMVFVCGTNAFNPMCRYYRLSTLEYD-GEEISGLARCPFDARQTNVALFADGKLYSA 186

Query: 180 TLNNFLGTEPIILRNMGPHHSMKT-EYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFF 238
           T+ +FL ++ +I R+MG   +++T +Y + W+ EPHF+ +       G++      VYFF
Sbjct: 187 TVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAI----EYGNY------VYFF 236

Query: 239 FRERAVESDCYAEQVVARVARVCKGDMGGA-RTLQRKWTTFLKARLACSAPNWQ-LYFNQ 296
           FRE AVE +   + V +RVAR+CK DMGG+ R L++ WT+FLKARL CS P     YF+ 
Sbjct: 237 FREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDV 296

Query: 297 LQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWD 356
           LQ++  +   +    T  GVF  Q   +  SA+C + +++I++VF+G +KE       W 
Sbjct: 297 LQSITDIIQIN-GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWT 355

Query: 357 RY-TDPVPSPRPGSCINNWHRRHG----YTSSLELPDNILNFVKKHPLMEEQVGPRWSRP 411
               D VP PRPG C      +HG    Y +S++ PD  L+F+K HPLM+  V P    P
Sbjct: 356 AVPEDKVPKPRPGCC-----AKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEP 410

Query: 412 LLVKKGTNF--THLVADRVTGLDGATYTVLFIGTGDGWLLKAV------SLGPWVHLIEE 463
              K    +  T +  D   G     YTV+F+G+  G +LK +      SL   V L+EE
Sbjct: 411 WFTKTRVRYRLTAISVDHSAG-PYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSV-LLEE 468

Query: 464 LQLF----------DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKYRSC-ADCVLA 512
           ++ +          + + + SL L +    L+    S ++++P++ C +Y SC   C+ +
Sbjct: 469 IEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIAS 528

Query: 513 RDPYCAW 519
           RDPYC W
Sbjct: 529 RDPYCGW 535


>gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]
          Length = 597

 Score =  268 bits (685), Expect = 2e-71
 Identities = 166/487 (34%), Positives = 259/487 (53%), Gaps = 52/487 (10%)

Query: 65  LYVGAREALFAFSMEALELQGAI-----SWEAPVEKKTECIQKGKNNQTECFNFIRFLQP 119
           LY+  R+ ++  ++  +     I     +W +  + +  C  KGK+   EC NFI+   P
Sbjct: 69  LYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECHNFIKVFVP 127

Query: 120 YNASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSA 179
            N   ++VCGT AF P C Y  + T   + GE   G  +CP+D  + +  L  DG+LYSA
Sbjct: 128 RNDEMVFVCGTNAFNPMCRYYRLSTLEYD-GEEISGLARCPFDARQTNVALFADGKLYSA 186

Query: 180 TLNNFLGTEPIILRNMGPHHSMKT-EYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFF 238
           T+ +FL ++ +I R+MG   +++T +Y + W+ EPHF+ +       G++      VYFF
Sbjct: 187 TVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAI----EYGNY------VYFF 236

Query: 239 FRERAVESDCYAEQVVARVARVCKGDMGGA-RTLQRKWTTFLKARLACSAPNWQ-LYFNQ 296
           FRE AVE +   + V +RVAR+CK DMGG+ R L++ WT+FLKARL CS P     YF+ 
Sbjct: 237 FREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDV 296

Query: 297 LQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWD 356
           LQ++  +   +    T  GVF  Q   +  SA+C + +++I++VF+G +KE       W 
Sbjct: 297 LQSITDIIQIN-GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWT 355

Query: 357 RY-TDPVPSPRPGSCINNWHRRHG----YTSSLELPDNILNFVKKHPLMEEQVGPRWSRP 411
               D VP PRPG C      +HG    Y +S++ PD  L+F+K HPLM+  V P    P
Sbjct: 356 AVPEDKVPKPRPGCC-----AKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEP 410

Query: 412 LLVKKGTNF--THLVADRVTGLDGATYTVLFIGTGDGWLLKAV------SLGPWVHLIEE 463
              K    +  T +  D   G     YTV+F+G+  G +LK +      SL   V L+EE
Sbjct: 411 WFTKTRVRYRLTAISVDHSAG-PYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSV-LLEE 468

Query: 464 LQLF----------DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKYRSC-ADCVLA 512
           ++ +          + + + SL L +    L+    S ++++P++ C +Y SC   C+ +
Sbjct: 469 IEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIAS 528

Query: 513 RDPYCAW 519
           RDPYC W
Sbjct: 529 RDPYCGW 535


>gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]
          Length = 1073

 Score =  268 bits (685), Expect = 2e-71
 Identities = 166/487 (34%), Positives = 259/487 (53%), Gaps = 52/487 (10%)

Query: 65  LYVGAREALFAFSMEALELQGAI-----SWEAPVEKKTECIQKGKNNQTECFNFIRFLQP 119
           LY+  R+ ++  ++  +     I     +W +  + +  C  KGK+   EC NFI+   P
Sbjct: 69  LYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECHNFIKVFVP 127

Query: 120 YNASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSA 179
            N   ++VCGT AF P C Y  + T   + GE   G  +CP+D  + +  L  DG+LYSA
Sbjct: 128 RNDEMVFVCGTNAFNPMCRYYRLSTLEYD-GEEISGLARCPFDARQTNVALFADGKLYSA 186

Query: 180 TLNNFLGTEPIILRNMGPHHSMKT-EYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFF 238
           T+ +FL ++ +I R+MG   +++T +Y + W+ EPHF+ +       G++      VYFF
Sbjct: 187 TVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAI----EYGNY------VYFF 236

Query: 239 FRERAVESDCYAEQVVARVARVCKGDMGGA-RTLQRKWTTFLKARLACSAPNWQ-LYFNQ 296
           FRE AVE +   + V +RVAR+CK DMGG+ R L++ WT+FLKARL CS P     YF+ 
Sbjct: 237 FREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDV 296

Query: 297 LQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWD 356
           LQ++  +   +    T  GVF  Q   +  SA+C + +++I++VF+G +KE       W 
Sbjct: 297 LQSITDIIQIN-GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWT 355

Query: 357 RY-TDPVPSPRPGSCINNWHRRHG----YTSSLELPDNILNFVKKHPLMEEQVGPRWSRP 411
               D VP PRPG C      +HG    Y +S++ PD  L+F+K HPLM+  V P    P
Sbjct: 356 AVPEDKVPKPRPGCC-----AKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEP 410

Query: 412 LLVKKGTNF--THLVADRVTGLDGATYTVLFIGTGDGWLLKAV------SLGPWVHLIEE 463
              K    +  T +  D   G     YTV+F+G+  G +LK +      SL   V L+EE
Sbjct: 411 WFTKTRVRYRLTAISVDHSAG-PYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSV-LLEE 468

Query: 464 LQLF----------DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKYRSC-ADCVLA 512
           ++ +          + + + SL L +    L+    S ++++P++ C +Y SC   C+ +
Sbjct: 469 IEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIAS 528

Query: 513 RDPYCAW 519
           RDPYC W
Sbjct: 529 RDPYCGW 535


>gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]
          Length = 1017

 Score =  268 bits (685), Expect = 2e-71
 Identities = 166/487 (34%), Positives = 259/487 (53%), Gaps = 52/487 (10%)

Query: 65  LYVGAREALFAFSMEALELQGAI-----SWEAPVEKKTECIQKGKNNQTECFNFIRFLQP 119
           LY+  R+ ++  ++  +     I     +W +  + +  C  KGK+   EC NFI+   P
Sbjct: 69  LYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECHNFIKVFVP 127

Query: 120 YNASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSA 179
            N   ++VCGT AF P C Y  + T   + GE   G  +CP+D  + +  L  DG+LYSA
Sbjct: 128 RNDEMVFVCGTNAFNPMCRYYRLSTLEYD-GEEISGLARCPFDARQTNVALFADGKLYSA 186

Query: 180 TLNNFLGTEPIILRNMGPHHSMKT-EYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFF 238
           T+ +FL ++ +I R+MG   +++T +Y + W+ EPHF+ +       G++      VYFF
Sbjct: 187 TVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAI----EYGNY------VYFF 236

Query: 239 FRERAVESDCYAEQVVARVARVCKGDMGGA-RTLQRKWTTFLKARLACSAPNWQ-LYFNQ 296
           FRE AVE +   + V +RVAR+CK DMGG+ R L++ WT+FLKARL CS P     YF+ 
Sbjct: 237 FREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDV 296

Query: 297 LQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWD 356
           LQ++  +   +    T  GVF  Q   +  SA+C + +++I++VF+G +KE       W 
Sbjct: 297 LQSITDIIQIN-GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWT 355

Query: 357 RY-TDPVPSPRPGSCINNWHRRHG----YTSSLELPDNILNFVKKHPLMEEQVGPRWSRP 411
               D VP PRPG C      +HG    Y +S++ PD  L+F+K HPLM+  V P    P
Sbjct: 356 AVPEDKVPKPRPGCC-----AKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEP 410

Query: 412 LLVKKGTNF--THLVADRVTGLDGATYTVLFIGTGDGWLLKAV------SLGPWVHLIEE 463
              K    +  T +  D   G     YTV+F+G+  G +LK +      SL   V L+EE
Sbjct: 411 WFTKTRVRYRLTAISVDHSAG-PYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSV-LLEE 468

Query: 464 LQLF----------DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKYRSC-ADCVLA 512
           ++ +          + + + SL L +    L+    S ++++P++ C +Y SC   C+ +
Sbjct: 469 IEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIAS 528

Query: 513 RDPYCAW 519
           RDPYC W
Sbjct: 529 RDPYCGW 535


>gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]
          Length = 998

 Score =  268 bits (685), Expect = 2e-71
 Identities = 166/487 (34%), Positives = 259/487 (53%), Gaps = 52/487 (10%)

Query: 65  LYVGAREALFAFSMEALELQGAI-----SWEAPVEKKTECIQKGKNNQTECFNFIRFLQP 119
           LY+  R+ ++  ++  +     I     +W +  + +  C  KGK+   EC NFI+   P
Sbjct: 69  LYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECHNFIKVFVP 127

Query: 120 YNASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSA 179
            N   ++VCGT AF P C Y  + T   + GE   G  +CP+D  + +  L  DG+LYSA
Sbjct: 128 RNDEMVFVCGTNAFNPMCRYYRLSTLEYD-GEEISGLARCPFDARQTNVALFADGKLYSA 186

Query: 180 TLNNFLGTEPIILRNMGPHHSMKT-EYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFF 238
           T+ +FL ++ +I R+MG   +++T +Y + W+ EPHF+ +       G++      VYFF
Sbjct: 187 TVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAI----EYGNY------VYFF 236

Query: 239 FRERAVESDCYAEQVVARVARVCKGDMGGA-RTLQRKWTTFLKARLACSAPNWQ-LYFNQ 296
           FRE AVE +   + V +RVAR+CK DMGG+ R L++ WT+FLKARL CS P     YF+ 
Sbjct: 237 FREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDV 296

Query: 297 LQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWD 356
           LQ++  +   +    T  GVF  Q   +  SA+C + +++I++VF+G +KE       W 
Sbjct: 297 LQSITDIIQIN-GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWT 355

Query: 357 RY-TDPVPSPRPGSCINNWHRRHG----YTSSLELPDNILNFVKKHPLMEEQVGPRWSRP 411
               D VP PRPG C      +HG    Y +S++ PD  L+F+K HPLM+  V P    P
Sbjct: 356 AVPEDKVPKPRPGCC-----AKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEP 410

Query: 412 LLVKKGTNF--THLVADRVTGLDGATYTVLFIGTGDGWLLKAV------SLGPWVHLIEE 463
              K    +  T +  D   G     YTV+F+G+  G +LK +      SL   V L+EE
Sbjct: 411 WFTKTRVRYRLTAISVDHSAG-PYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSV-LLEE 468

Query: 464 LQLF----------DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKYRSC-ADCVLA 512
           ++ +          + + + SL L +    L+    S ++++P++ C +Y SC   C+ +
Sbjct: 469 IEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIAS 528

Query: 513 RDPYCAW 519
           RDPYC W
Sbjct: 529 RDPYCGW 535


>gi|16306552 semaphorin Y [Homo sapiens]
          Length = 930

 Score =  261 bits (668), Expect = 1e-69
 Identities = 182/517 (35%), Positives = 269/517 (52%), Gaps = 58/517 (11%)

Query: 51  QDFLTLTLTEPTGLLYVGAREALFAFSMEALEL-QGAI-----SWEAPVEKKTECIQKGK 104
           Q FLTL  T     L V AR+ +F+F ++A E  +G +     +W +  +    C  +GK
Sbjct: 64  QRFLTLNRT-----LLVAARDHVFSFDLQAEEEGEGLVPNKYLTWRS--QDVENCAVRGK 116

Query: 105 NNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPA 164
               EC+N+IR L P+++  L  CGT +F P C     +T   + GE   G+ +CP+D  
Sbjct: 117 LTD-ECYNYIRVLVPWDSQTLLACGTNSFSPVCRSYG-ITSLQQEGEELSGQARCPFDAT 174

Query: 165 KGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKT-EYLAFWLNEPHFVGSAYVPE 223
           + +  +  +G LYSAT  +F  ++ ++ R++GP   +++ +Y + WL EPHFV +     
Sbjct: 175 QSNVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVQA----- 229

Query: 224 SVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGA-RTLQRKWTTFLKAR 282
                    D VYFFFRE +VE         +RVARVCK DMGG+ R L R WT+FLK R
Sbjct: 230 -----LEHGDHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLR 284

Query: 283 LACSAP-NWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVF 341
           L CS P +   YF+ LQA+ T        +  FGVF  Q   +  SA+C + L+EI+R F
Sbjct: 285 LNCSVPGDSTFYFDVLQAL-TGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGF 343

Query: 342 EGPYKEYHEEAQKWDRYT-DPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLM 400
           EG +KE       W   + D VPSPRPGSC         ++SS +LPD++L F+K HPL+
Sbjct: 344 EGKFKEQRSLDGAWTPVSEDRVPSPRPGSCAGVGGAAL-FSSSRDLPDDVLTFIKAHPLL 402

Query: 401 EEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDG--ATYTVLFIGTGDGWLLKAV-----S 453
           +  V P   +PLL    T+   L    V G+ G  +  TV+F+G+ DG +LK +     S
Sbjct: 403 DPAVPPVTHQPLLTL--TSRALLTQVAVDGMAGPHSNITVMFLGSNDGTVLKVLTPGGRS 460

Query: 454 LGPWVHLIEELQLFDQEPMR--------------SLVLSQSKKLLFAGSRSQLVQLPVAD 499
            GP   L+EE+  +   P R               L L      LF      +V LP++ 
Sbjct: 461 GGPEPILLEEIDAY--SPARCSGKRTAQTARRIIGLELDTEGHRLFVAFSGCIVYLPLSR 518

Query: 500 CMKYRSC-ADCVLARDPYCAWSVNTSRCVAVGGHSGS 535
           C ++ +C   C+ ++DPYC W  ++  CV + G  G+
Sbjct: 519 CARHGACQRSCLASQDPYCGWH-SSRGCVDIRGSGGT 554


>gi|11991660 sema domain, transmembrane domain (TM), and cytoplasmic
           domain, (semaphorin) 6A [Homo sapiens]
          Length = 1030

 Score =  254 bits (649), Expect = 2e-67
 Identities = 166/521 (31%), Positives = 261/521 (50%), Gaps = 43/521 (8%)

Query: 63  GLLYVGAREALFAFSM-----EALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFL 117
           G LY+ AR+ ++   +     E +     ++W++       C  KGK+   EC NFI+ L
Sbjct: 66  GTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKD-ECHNFIKVL 124

Query: 118 QPYNASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELY 177
              N   L+VCGT AF P C    M T      EF  G  +CPYD    +  L  DG+LY
Sbjct: 125 LKKNDDALFVCGTNAFNPSCRNYKMDTLEPFGDEFS-GMARCPYDAKHANVALFADGKLY 183

Query: 178 SATLNNFLGTEPIILRNMGPHHSMKT-EYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVY 236
           SAT+ +FL  + +I R++G   +++T ++ + WL EP+FV +              D +Y
Sbjct: 184 SATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQA----------VDYGDYIY 233

Query: 237 FFFRERAVESDCYAEQVVARVARVCKGDMGGA-RTLQRKWTTFLKARLACSAP-NWQLYF 294
           FFFRE AVE +   + V  RVA+VCK DMGG+ R L+++WT+FLKARL CS P +   YF
Sbjct: 234 FFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYF 293

Query: 295 NQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQK 354
           N LQA+  +   +  +      F   +  +  SA+C Y + +I  VF G +KE       
Sbjct: 294 NILQAVTDVIRINGRDVV-LATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDST 352

Query: 355 WDRYTDP-VPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLL 413
           W    D  VP PRPG C  +      Y +S E PD+ LNF+K HPLM+E V   ++RP  
Sbjct: 353 WTPVPDERVPKPRPGCCAGS-SSLERYATSNEFPDDTLNFIKTHPLMDEAVPSIFNRPWF 411

Query: 414 VKKGTNF--THLVADRVTGLDGATYTVLFIGTGDGWLLKAVS-LGPWVHL-----IEELQ 465
           ++    +  T +  D   G     +TV+F+G+  G +LK ++ +G    L     +EE+ 
Sbjct: 412 LRTMVRYRLTKIAVDTAAG-PYQNHTVVFLGSEKGIILKFLARIGNSGFLNDSLFLEEMS 470

Query: 466 LFDQEP----------MRSLVLSQSKKLLFAGSRSQLVQLPVADCMKYRSC-ADCVLARD 514
           +++ E           +  + L ++   L+    + ++++P+  C ++  C   C+ +RD
Sbjct: 471 VYNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRD 530

Query: 515 PYCAWSVNTSRCVAVGGHSGSLLIQHVMTSDTSGICNLRGS 555
           PYC W      C  +  +S     Q +   +T G+ +   S
Sbjct: 531 PYCGWIKEGGACSHLSPNSRLTFEQDIERGNTDGLGDCHNS 571


>gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]
          Length = 476

 Score =  238 bits (608), Expect = 1e-62
 Identities = 149/425 (35%), Positives = 229/425 (53%), Gaps = 41/425 (9%)

Query: 65  LYVGAREALFAFSMEALELQGAI-----SWEAPVEKKTECIQKGKNNQTECFNFIRFLQP 119
           LY+  R+ ++  ++  +     I     +W +  + +  C  KGK+   EC NFI+   P
Sbjct: 69  LYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECHNFIKVFVP 127

Query: 120 YNASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSA 179
            N   ++VCGT AF P C Y  + T   + GE   G  +CP+D  + +  L  DG+LYSA
Sbjct: 128 RNDEMVFVCGTNAFNPMCRYYRLSTLEYD-GEEISGLARCPFDARQTNVALFADGKLYSA 186

Query: 180 TLNNFLGTEPIILRNMGPHHSMKT-EYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFF 238
           T+ +FL ++ +I R+MG   +++T +Y + W+ EPHF+ +       G++      VYFF
Sbjct: 187 TVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAI----EYGNY------VYFF 236

Query: 239 FRERAVESDCYAEQVVARVARVCKGDMGGA-RTLQRKWTTFLKARLACSAPNWQ-LYFNQ 296
           FRE AVE +   + V +RVAR+CK DMGG+ R L++ WT+FLKARL CS P     YF+ 
Sbjct: 237 FREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDV 296

Query: 297 LQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWD 356
           LQ++  +   +    T  GVF  Q   +  SA+C + +++I++VF+G +KE       W 
Sbjct: 297 LQSITDIIQIN-GIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWT 355

Query: 357 RY-TDPVPSPRPGSCINNWHRRHG----YTSSLELPDNILNFVKKHPLMEEQVGPRWSRP 411
               D VP PRPG C      +HG    Y +S++ PD  L+F+K HPLM+  V P    P
Sbjct: 356 AVPEDKVPKPRPGCC-----AKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEP 410

Query: 412 LLVKKGTNF--THLVADRVTGLDGATYTVLFIGTGDGWLLKAV------SLGPWVHLIEE 463
              K    +  T +  D   G     YTV+F+G+  G +LK +      SL   V L+EE
Sbjct: 411 WFTKTRVRYRLTAISVDHSAG-PYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSV-LLEE 468

Query: 464 LQLFD 468
           ++ ++
Sbjct: 469 IEAYN 473


>gi|19718780 semaphorin 6B precursor [Homo sapiens]
          Length = 888

 Score =  236 bits (603), Expect = 5e-62
 Identities = 173/523 (33%), Positives = 264/523 (50%), Gaps = 52/523 (9%)

Query: 65  LYVGAREALFAFSMEA-----LELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQP 119
           L++G R+ L+   +E      L  Q  ++W +       C  KGK  + EC NF++ L  
Sbjct: 77  LFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQ-EGECRNFVKVLLL 135

Query: 120 YNASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSA 179
            + S L+VCG+ AF P C   ++ T     G+   G  +CPYDP   +  L  DG L++A
Sbjct: 136 RDESTLFVCGSNAFNPVCANYSIDTLQ-PVGDNISGMARCPYDPKHANVALFSDGMLFTA 194

Query: 180 TLNNFLGTEPIILRNMGPHHSMKT-EYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFF 238
           T+ +FL  + +I R++G   +++T ++ + W  EP+FV +       GS       VYFF
Sbjct: 195 TVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAV----EWGS------HVYFF 244

Query: 239 FRERAVESDCYAEQVVARVARVCKGDMGGA-RTLQRKWTTFLKARLACSAP-NWQLYFNQ 296
           FRE A+E +   + VV+RVARVCK D+GG+ R L+++WT+FLKARL CS P +   YFN 
Sbjct: 245 FREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNV 304

Query: 297 LQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWD 356
           LQA+  +            VF      +  SA+C + L ++  VFEG ++E       W 
Sbjct: 305 LQAVTGVVSLG-GRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWT 363

Query: 357 RY-TDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVK 415
               D VP PRPG C     +   Y +S  LPD+ILNFVK HPLM+E V      P +++
Sbjct: 364 PVPEDQVPRPRPGCCAAPGMQ---YNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILR 420

Query: 416 --KGTNFTHLVADRVTGLDGATYTVLFIGTGDGWLLKAV---------SLGPWVHLIEEL 464
                  T +  D   G  G   TV+F+G+  G +LK +         + G  V L EE 
Sbjct: 421 TLMRHQLTRVAVDVGAGPWG-NQTVVFLGSEAGTVLKFLVRPNASTSGTSGLSVFL-EEF 478

Query: 465 QLF------------DQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKYRSC-ADCVL 511
           + +              + + SL L  +   L A     +V++PVA C +Y  C  +C+ 
Sbjct: 479 ETYRPDRCGRPGGGETGQRLLSLELDAASGGLLAAFPRCVVRVPVARCQQYSGCMKNCIG 538

Query: 512 ARDPYCAWSVNTSRCVAVGGHSGSLLIQHVMTSDTSGICNLRG 554
           ++DPYC W+ + S C+ +   + +   Q V  + TSG+ +  G
Sbjct: 539 SQDPYCGWAPDGS-CIFLSPGTRAAFEQDVSGASTSGLGDCTG 580


>gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]
          Length = 652

 Score =  167 bits (424), Expect = 3e-41
 Identities = 150/546 (27%), Positives = 240/546 (43%), Gaps = 60/546 (10%)

Query: 102 KGKNN--QTECFNFIRFLQPYNASHLYVCGTYAFQPKC-TYVNMLTFTLEHGEFEDGKGK 158
           +GKN   +T+C N+I  L+   +  L  CGT A  P C   VN     L  GE    +G 
Sbjct: 102 EGKNASVRTDCENYITLLER-RSEGLLACGTNARHPSCWNLVNGTVVPL--GEM---RGY 155

Query: 159 CPYDPAKGHAGLLVDGELYSATLNN-FLGTEPIILRNMGPHHSMKTEYLAFWLNEPHFVG 217
            P+ P +    L    E+YS      + G  P   R  G      ++ +   +  P F+ 
Sbjct: 156 APFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV---MQNPQFIK 212

Query: 218 SAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQ-RKWT 276
           +  V +        DDK+Y+FFRE   + +  A   V+RVA++C+GD GG  +L   KW 
Sbjct: 213 ATIVHQDQAY----DDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWN 268

Query: 277 TFLKARLACSAPNWQLYFNQLQAMHTLQDTS--WHNTTFFGVFQAQWGDMYLSAICEYQL 334
           TFLKA L CS       FN+LQ +  L D S  W +T  +GVF   W     SA+C Y L
Sbjct: 269 TFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWN---YSAVCVYSL 325

Query: 335 EEIQRVFE-GPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNF 393
            +I +VF     K YH            +P+PRPG C+              +P      
Sbjct: 326 GDIDKVFRTSSLKGYHSS----------LPNPRPGKCL---------PDQQPIPTETFQV 366

Query: 394 VKKHPLMEEQVGPR--WSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIGTGDGWLLKA 451
             +HP + ++V P      PL   K  ++  +   R+    G T+ VL++ T  G + K 
Sbjct: 367 ADRHPEVAQRVEPMGPLKTPLFHSK-YHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKV 425

Query: 452 VSLGPWVHL----IEELQLFDQ-EPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKY-RS 505
           V  G   H     I E+Q F +   ++++ L   ++ L+  S+ ++ Q+P+  C  Y   
Sbjct: 426 VEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGG 485

Query: 506 CADCVLARDPYCAWSVNTSRCVAVGGHSGSLLIQHVMTSDTSGICNLRGSKKVRPTPKNI 565
           C  C+++RDPYC W  +  RC+++     S+L Q +  ++    C     K  +   + +
Sbjct: 486 CHGCLMSRDPYCGW--DQGRCISIYSSERSVL-QSINPAEPHKEC--PNPKPDKAPLQKV 540

Query: 566 TVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLYDARLQALVVMAAQPRHAGAY 625
           ++   +   L C + S  A   W        + +PG   + +    L +     +  G Y
Sbjct: 541 SLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPG---HQSPNCILFIENLTAQQYGHY 597

Query: 626 HCFSEE 631
            C ++E
Sbjct: 598 FCEAQE 603


>gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]
          Length = 666

 Score =  165 bits (417), Expect = 2e-40
 Identities = 149/550 (27%), Positives = 238/550 (43%), Gaps = 63/550 (11%)

Query: 96  KTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKC-TYVNMLTFTLEHGEFED 154
           K  C+ K      +C N+I  L+   +  L  CGT A  P C   VN     L  GE   
Sbjct: 117 KGSCLDK-----RDCENYITLLER-RSEGLLACGTNARHPSCWNLVNGTVVPL--GEM-- 166

Query: 155 GKGKCPYDPAKGHAGLLVDGELYSATLNN-FLGTEPIILRNMGPHHSMKTEYLAFWLNEP 213
            +G  P+ P +    L    E+YS      + G  P   R  G      ++ +   +  P
Sbjct: 167 -RGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV---MQNP 222

Query: 214 HFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQ- 272
            F+ +  V +        DDK+Y+FFRE   + +  A   V+RVA++C+GD GG  +L  
Sbjct: 223 QFIKATIVHQDQAY----DDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSV 278

Query: 273 RKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDTS--WHNTTFFGVFQAQWGDMYLSAIC 330
            KW TFLKA L CS       FN+LQ +  L D S  W +T  +GVF   W     SA+C
Sbjct: 279 SKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWN---YSAVC 335

Query: 331 EYQLEEIQRVFE-GPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDN 389
            Y L +I +VF     K YH            +P+PRPG C+              +P  
Sbjct: 336 VYSLGDIDKVFRTSSLKGYHSS----------LPNPRPGKCL---------PDQQPIPTE 376

Query: 390 ILNFVKKHPLMEEQVGPR--WSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIGTGDGW 447
                 +HP + ++V P      PL   K  ++  +   R+    G T+ VL++ T  G 
Sbjct: 377 TFQVADRHPEVAQRVEPMGPLKTPLFHSK-YHYQKVAVHRMQASHGETFHVLYLTTDRGT 435

Query: 448 LLKAVSLGPWVHL----IEELQLFDQ-EPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMK 502
           + K V  G   H     I E+Q F +   ++++ L   ++ L+  S+ ++ Q+P+  C  
Sbjct: 436 IHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEV 495

Query: 503 Y-RSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLLIQHVMTSDTSGICNLRGSKKVRPT 561
           Y   C  C+++RDPYC W  +  RC+++     S+L Q +  ++    C     K  +  
Sbjct: 496 YGGGCHGCLMSRDPYCGW--DQGRCISIYSSERSVL-QSINPAEPHKEC--PNPKPDKAP 550

Query: 562 PKNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLYDARLQALVVMAAQPRH 621
            + +++   +   L C + S  A   W        + +PG   + +    L +     + 
Sbjct: 551 LQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPG---HQSPNCILFIENLTAQQ 607

Query: 622 AGAYHCFSEE 631
            G Y C ++E
Sbjct: 608 YGHYFCEAQE 617


>gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]
          Length = 501

 Score =  153 bits (387), Expect = 6e-37
 Identities = 130/489 (26%), Positives = 214/489 (43%), Gaps = 51/489 (10%)

Query: 156 KGKCPYDPAKGHAGLLVDGELYSATLNN-FLGTEPIILRNMGPHHSMKTEYLAFWLNEPH 214
           +G  P+ P +    L    E+YS      + G  P   R  G      ++ +   +  P 
Sbjct: 2   RGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV---MQNPQ 58

Query: 215 FVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQ-R 273
           F+ +  V +        DDK+Y+FFRE   + +  A   V+RVA++C+GD GG  +L   
Sbjct: 59  FIKATIVHQDQAY----DDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVS 114

Query: 274 KWTTFLKARLACSAPNWQLYFNQLQAMHTLQDTS--WHNTTFFGVFQAQWGDMYLSAICE 331
           KW TFLKA L CS       FN+LQ +  L D S  W +T  +GVF   W     SA+C 
Sbjct: 115 KWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWN---YSAVCV 171

Query: 332 YQLEEIQRVFE-GPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNI 390
           Y L +I +VF     K YH            +P+PRPG C+              +P   
Sbjct: 172 YSLGDIDKVFRTSSLKGYHSS----------LPNPRPGKCL---------PDQQPIPTET 212

Query: 391 LNFVKKHPLMEEQVGPR--WSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIGTGDGWL 448
                +HP + ++V P      PL   K  ++  +   R+    G T+ VL++ T  G +
Sbjct: 213 FQVADRHPEVAQRVEPMGPLKTPLFHSK-YHYQKVAVHRMQASHGETFHVLYLTTDRGTI 271

Query: 449 LKAVSLGPWVHL----IEELQLFDQ-EPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKY 503
            K V  G   H     I E+Q F +   ++++ L   ++ L+  S+ ++ Q+P+  C  Y
Sbjct: 272 HKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVY 331

Query: 504 -RSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLLIQHVMTSDTSGICNLRGSKKVRPTP 562
              C  C+++RDPYC W  +  RC+++     S+L Q +  ++    C     K  +   
Sbjct: 332 GGGCHGCLMSRDPYCGW--DQGRCISIYSSERSVL-QSINPAEPHKEC--PNPKPDKAPL 386

Query: 563 KNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLYDARLQALVVMAAQPRHA 622
           + +++   +   L C + S  A   W        + +PG   + +    L +     +  
Sbjct: 387 QKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPG---HQSPNCILFIENLTAQQY 443

Query: 623 GAYHCFSEE 631
           G Y C ++E
Sbjct: 444 GHYFCEAQE 452


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.437 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,341,416
Number of Sequences: 37866
Number of extensions: 2024024
Number of successful extensions: 11158
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 175
Number of HSP's that attempted gapping in prelim test: 9891
Number of HSP's gapped (non-prelim): 1117
length of query: 833
length of database: 18,247,518
effective HSP length: 111
effective length of query: 722
effective length of database: 14,044,392
effective search space: 10140051024
effective search space used: 10140051024
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.