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Search of human proteins with 157364939
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157364939 phosphodiesterase 6C [Homo sapiens]
(858 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157364939 phosphodiesterase 6C [Homo sapiens] 1734 0.0
gi|170650674 phosphodiesterase 6A [Homo sapiens] 1143 0.0
gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens] 1141 0.0
gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens] 1137 0.0
gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens] 838 0.0
gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens] 414 e-115
gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens] 387 e-107
gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens] 377 e-104
gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens] 377 e-104
gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens] 377 e-104
gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens] 350 4e-96
gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens] 329 8e-90
gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens] 259 1e-68
gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens] 259 1e-68
gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens] 259 1e-68
gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens] 238 2e-62
gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens] 238 2e-62
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 141 2e-33
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 141 2e-33
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 141 3e-33
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 141 3e-33
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 141 3e-33
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 141 3e-33
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 129 2e-29
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 129 2e-29
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 129 2e-29
gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens] 129 2e-29
gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens] 129 2e-29
gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens] 129 2e-29
gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens] 129 2e-29
>gi|157364939 phosphodiesterase 6C [Homo sapiens]
Length = 858
Score = 1734 bits (4490), Expect = 0.0
Identities = 858/858 (100%), Positives = 858/858 (100%)
Query: 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA 60
MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA
Sbjct: 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA 60
Query: 61 LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT 120
LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT
Sbjct: 61 LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT 120
Query: 121 SKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL 180
SKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL
Sbjct: 121 SKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL 180
Query: 181 ATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRS 240
ATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRS
Sbjct: 181 ATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRS 240
Query: 241 QILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGE 300
QILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGE
Sbjct: 241 QILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGE 300
Query: 301 VEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN 360
VEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN
Sbjct: 301 VEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN 360
Query: 361 MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY 420
MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY
Sbjct: 361 MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY 420
Query: 421 ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD 480
ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD
Sbjct: 421 ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD 480
Query: 481 VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKV 540
VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKV
Sbjct: 481 VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKV 540
Query: 541 PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF 600
PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF
Sbjct: 541 PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF 600
Query: 601 CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET 660
CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET
Sbjct: 601 CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET 660
Query: 661 VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT 720
VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT
Sbjct: 661 VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT 720
Query: 721 ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI 780
ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI
Sbjct: 721 ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI 780
Query: 781 DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKA 840
DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKA
Sbjct: 781 DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKA 840
Query: 841 AEDSGGGDDKKSKTCLML 858
AEDSGGGDDKKSKTCLML
Sbjct: 841 AEDSGGGDDKKSKTCLML 858
>gi|170650674 phosphodiesterase 6A [Homo sapiens]
Length = 860
Score = 1143 bits (2956), Expect = 0.0
Identities = 548/860 (63%), Positives = 695/860 (80%), Gaps = 8/860 (0%)
Query: 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA 60
MGE+ VEK+L+ N FAK+Y++ R +++ ++ + V S ++ + +EES
Sbjct: 1 MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFS-NYHSPSSMEESE 59
Query: 61 LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT 120
+ +LL QE T E+ + +++L LLQADR S+F+ R+RNGI E+A+RL +V
Sbjct: 60 IIFDLLRDFQENLQT-EKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKD 118
Query: 121 SKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL 180
+ ED LV PD+E+VFPLD+GIVG AH+KK NVP+ +++ HF DF+D T Y TKN+L
Sbjct: 119 AVLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNIL 178
Query: 181 ATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRS 240
A+PI+ GK+V+A+IMAVNKV+ S F+K+DEE+ KYLNF ++I++++H SY++N E+RR
Sbjct: 179 ASPIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRG 238
Query: 241 QILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGE 300
QIL+WS +KVFEELTD+ERQFHKALYTVR++LNC+RYS+GLLDMTK+KEF+D WP+ +GE
Sbjct: 239 QILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGE 298
Query: 301 VEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN 360
V PY GP+TPDGRE+NFYK+IDYILHGKE+IKVIP PP DHW L+SGLP YVA+NG ICN
Sbjct: 299 VPPYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICN 358
Query: 361 MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY 420
+MNAPA+++F FQK P+DE+GW+IKNVLS+PIVNKKE+IVGVATFYNRKDGKPFDE DE
Sbjct: 359 IMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDET 418
Query: 421 ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD 480
+ E+LTQFLGWS+LN DTY+ MNKLENRKDI Q+++ K EEI+ ILK +E +
Sbjct: 419 LMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKE 478
Query: 481 VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKV 540
+CEE++L IL+ +LPD E+ +F FSD PLTE L+KCGI++++E+ VV+KF +
Sbjct: 479 PW-ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHI 537
Query: 541 PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF 600
P E L R+MY++ KGYR +TYHNWRHGFNVGQTMF+LL+TG+LK+Y+TDLEA AM+ AAF
Sbjct: 538 PQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAF 597
Query: 601 CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET 660
CHDIDHRGTNNLYQMKS +PLA+LHGSSILERHHLE+ KTLL+DESLNIFQNLN+RQ E
Sbjct: 598 CHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEH 657
Query: 661 VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT 720
IH+ ++AIIATDLALYFKKRTMFQKIVD + ++E+E +Y+ ++ T+KEI+MAMMMT
Sbjct: 658 AIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMT 717
Query: 721 ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI 780
ACDLSAITKPWEVQSQVAL+VA EFWEQGDLERTVLQQ PIPMMDRNK DELPKLQVGFI
Sbjct: 718 ACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFI 777
Query: 781 DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKA 840
DFVCTFVYKEFSRFH+EITPML G+ NNR EWK+LADEYDAKMKV EE+ +KQ+ A
Sbjct: 778 DFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAA 837
Query: 841 AEDSGGGDDK-----KSKTC 855
A + GG+ SK+C
Sbjct: 838 AGNQPGGNPSPGGATTSKSC 857
>gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]
Length = 853
Score = 1141 bits (2952), Expect = 0.0
Identities = 551/855 (64%), Positives = 684/855 (80%), Gaps = 4/855 (0%)
Query: 4 INQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCL 63
+++ +L++NP FA++YF +KL E + ++ P S+ +L QVEES L
Sbjct: 3 LSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLR--DLCQVEESTALL 60
Query: 64 ELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKF 123
EL+ +QE E+ V + L+RL LLQADRCS+F+ R RNG+ E+A+RL V P S
Sbjct: 61 ELVQDMQESINM-ERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVL 119
Query: 124 EDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATP 183
ED LV PD E+VFPLDIG+VG A TKK NV DV + HFS F D+ T Y TKN+LATP
Sbjct: 120 EDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATP 179
Query: 184 IVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQIL 243
I+ GK+V+AVIMAVNK+N F+ +DE+VF KYLNF ++ L+++H SY++N E+RR Q+L
Sbjct: 180 IMNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVL 239
Query: 244 MWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEP 303
+WSANKVFEELTD+ERQFHKA YTVR+YLNCERYS+GLLDMTKEKEF+D W + +GE +P
Sbjct: 240 LWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQP 299
Query: 304 YKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMN 363
Y GP+TPDGRE+ FYK+IDYILHGKEEIKVIPTP ADHW L SGLP+YVAE+GFICN+MN
Sbjct: 300 YSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMN 359
Query: 364 APADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITE 423
A ADE F FQ+G +D++GW+IKNVLS+PIVNKKE+IVGVATFYNRKDGKPFDE DE + E
Sbjct: 360 ASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLME 419
Query: 424 TLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVID 483
+LTQFLGWS++NTDTYDKMNKLENRKDIAQ+M++ K +EI+ IL + +L +
Sbjct: 420 SLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPA- 478
Query: 484 DCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVE 543
DC+E +L ILKE+LP P + ++YEF FSD TE L+KCGI++++E+ VV KF++P E
Sbjct: 479 DCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQE 538
Query: 544 VLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHD 603
VL R+++++ KGYR +TYHNWRHGFNV QTMFTLLMTG+LK YYTDLEAFAM+ A CHD
Sbjct: 539 VLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHD 598
Query: 604 IDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIH 663
IDHRGTNNLYQMKS +PLA+LHGSSILERHHLE+ K LL +E+LNI+QNLN+RQ E VIH
Sbjct: 599 IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIH 658
Query: 664 LFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACD 723
L ++AIIATDLALYFKKR MFQKIVD + Q ++ ++Y++++ T+KEI+MAMMMTACD
Sbjct: 659 LMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACD 718
Query: 724 LSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFV 783
LSAITKPWEVQS+VAL+VA EFWEQGDLERTVL QQPIPMMDRNK ELPKLQVGFIDFV
Sbjct: 719 LSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFV 778
Query: 784 CTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAED 843
CTFVYKEFSRFH+EI PM LQNNR EWK+LADEY+AK+K +EE+ +++ A+K E
Sbjct: 779 CTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKGTEI 838
Query: 844 SGGGDDKKSKTCLML 858
GG KS TC +L
Sbjct: 839 CNGGPAPKSSTCCIL 853
>gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]
Length = 854
Score = 1137 bits (2940), Expect = 0.0
Identities = 551/856 (64%), Positives = 684/856 (79%), Gaps = 5/856 (0%)
Query: 4 INQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCL 63
+++ +L++NP FA++YF +KL E + ++ P S+ +L QVEES L
Sbjct: 3 LSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLR--DLCQVEESTALL 60
Query: 64 ELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKF 123
EL+ +QE E+ V + L+RL LLQADRCS+F+ R RNG+ E+A+RL V P S
Sbjct: 61 ELVQDMQESINM-ERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVL 119
Query: 124 EDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATP 183
ED LV PD E+VFPLDIG+VG A TKK NV DV + HFS F D+ T Y TKN+LATP
Sbjct: 120 EDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATP 179
Query: 184 IVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQIL 243
I+ GK+V+AVIMAVNK+N F+ +DE+VF KYLNF ++ L+++H SY++N E+RR Q+L
Sbjct: 180 IMNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVL 239
Query: 244 MWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEP 303
+WSANKVFEELTD+ERQFHKA YTVR+YLNCERYS+GLLDMTKEKEF+D W + +GE +P
Sbjct: 240 LWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQP 299
Query: 304 YKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMN 363
Y GP+TPDGRE+ FYK+IDYILHGKEEIKVIPTP ADHW L SGLP+YVAE+GFICN+MN
Sbjct: 300 YSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMN 359
Query: 364 APADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITE 423
A ADE F FQ+G +D++GW+IKNVLS+PIVNKKE+IVGVATFYNRKDGKPFDE DE + E
Sbjct: 360 ASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLME 419
Query: 424 TLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVID 483
+LTQFLGWS++NTDTYDKMNKLENRKDIAQ+M++ K +EI+ IL + +L +
Sbjct: 420 SLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPA- 478
Query: 484 DCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVE 543
DC+E +L ILKE+LP P + ++YEF FSD TE L+KCGI++++E+ VV KF++P E
Sbjct: 479 DCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQE 538
Query: 544 VLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHD 603
VL R+++++ KGYR +TYHNWRHGFNV QTMFTLLMTG+LK YYTDLEAFAM+ A CHD
Sbjct: 539 VLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHD 598
Query: 604 IDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIH 663
IDHRGTNNLYQMKS +PLA+LHGSSILERHHLE+ K LL +E+LNI+QNLN+RQ E VIH
Sbjct: 599 IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIH 658
Query: 664 LFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACD 723
L ++AIIATDLALYFKKR MFQKIVD + Q ++ ++Y++++ T+KEI+MAMMMTACD
Sbjct: 659 LMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACD 718
Query: 724 LSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFV 783
LSAITKPWEVQS+VAL+VA EFWEQGDLERTVL QQPIPMMDRNK ELPKLQVGFIDFV
Sbjct: 719 LSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFV 778
Query: 784 CTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEK-AAE 842
CTFVYKEFSRFH+EI PM LQNNR EWK+LADEY+AK+K +EE+ +++ A+K E
Sbjct: 779 CTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTE 838
Query: 843 DSGGGDDKKSKTCLML 858
GG KS TC +L
Sbjct: 839 ICNGGPAPKSSTCCIL 854
>gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]
Length = 575
Score = 838 bits (2164), Expect = 0.0
Identities = 397/576 (68%), Positives = 481/576 (83%), Gaps = 2/576 (0%)
Query: 284 MTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWT 343
MTKEKEF+D W + +GE +PY GP+TPDGRE+ FYK+IDYILHGKEEIKVIPTP ADHW
Sbjct: 1 MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA 60
Query: 344 LISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVA 403
L SGLP+YVAE+GFICN+MNA ADE F FQ+G +D++GW+IKNVLS+PIVNKKE+IVGVA
Sbjct: 61 LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA 120
Query: 404 TFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKAT 463
TFYNRKDGKPFDE DE + E+LTQFLGWS++NTDTYDKMNKLENRKDIAQ+M++ K
Sbjct: 121 TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 180
Query: 464 PEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIK 523
+EI+ IL + +L + D C+E +L ILKE+LP P + ++YEF FSD TE L+K
Sbjct: 181 RDEIQLILPTRARLGKEPAD-CDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVK 239
Query: 524 CGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRL 583
CGI++++E+ VV KF++P EVL R+++++ KGYR +TYHNWRHGFNV QTMFTLLMTG+L
Sbjct: 240 CGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKL 299
Query: 584 KKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQ 643
K YYTDLEAFAM+ A CHDIDHRGTNNLYQMKS +PLA+LHGSSILERHHLE+ K LL
Sbjct: 300 KSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLS 359
Query: 644 DESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKY 703
+E+LNI+QNLN+RQ E VIHL ++AIIATDLALYFKKR MFQKIVD + Q ++ ++Y
Sbjct: 360 EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEY 419
Query: 704 VTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPM 763
++++ T+KEI+MAMMMTACDLSAITKPWEVQS+VAL+VA EFWEQGDLERTVL QQPIPM
Sbjct: 420 LSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPM 479
Query: 764 MDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKM 823
MDRNK ELPKLQVGFIDFVCTFVYKEFSRFH+EI PM LQNNR EWK+LADEY+AK+
Sbjct: 480 MDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKV 539
Query: 824 KVIEEEAKKQEGGAEK-AAEDSGGGDDKKSKTCLML 858
K +EE+ +++ A+K E GG KS TC +L
Sbjct: 540 KALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL 575
Score = 37.0 bits (84), Expect = 0.078
Identities = 52/227 (22%), Positives = 93/227 (40%), Gaps = 35/227 (15%)
Query: 102 RSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKN 161
R+ +G V +++D K E ++ + L G+ + A + N+ + +
Sbjct: 25 RTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASAD 84
Query: 162 SHFSDFMD---KQTGYVTKNLLATPIVVGK-EVLAVIMAVNKVNASEFSKQDEEVFSKYL 217
F F + +G++ KN+L+ PIV K E++ V N+ + F +QDE +
Sbjct: 85 EMFK-FQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESL- 142
Query: 218 NFVSIILRLHHTSYMYNIESRRSQILMWSA--NKVFEELTDVERQFHKALYTVRSYLNCE 275
+Q L WS ++++ +E + A V ++ C+
Sbjct: 143 ----------------------TQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 180
Query: 276 RYSIGLLDMTKE---KEFYDEWPIKLGEV--EPYKGPKTPDGREVNF 317
R I L+ T+ KE D +LGE+ E GP T D E +F
Sbjct: 181 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHF 227
>gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]
Length = 933
Score = 414 bits (1064), Expect = e-115
Identities = 249/736 (33%), Positives = 387/736 (52%), Gaps = 69/736 (9%)
Query: 90 LLQADRCSMFLCR-SRNGIPEVASRLLDV------TPTSKFEDNLVGPDKEVVFPLDIGI 142
++ ADRCS+FL + G + S+ DV P S E++ EV P GI
Sbjct: 232 MVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENS-----NEVQVPWGKGI 286
Query: 143 VGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGK-EVLAVIMAVNKV- 200
+G+ +T N+PD ++ F+D +DK TGY TK+LL PI E++ V A+NK+
Sbjct: 287 IGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIP 346
Query: 201 NASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQ 260
+ F++ DE+V YL F I + E RS+ L+ N +FEE TD+E+
Sbjct: 347 EGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKI 406
Query: 261 FHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKI 320
K ++ ++ L CER S+ LL E + +K + PK E +F +
Sbjct: 407 VKKIMHRAQTLLKCERCSVLLL------EDIESPVVKFTKSFELMSPKCSADAENSFKES 460
Query: 321 IDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDET 380
++ + W + + + VA G N+ +A D F + + +
Sbjct: 461 MEKSSYSD-------------WLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--S 505
Query: 381 GWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYD 440
G+ I++VL +PI N I+GVA NR DGKPFD+ D+ + E F G + NT YD
Sbjct: 506 GFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYD 565
Query: 441 KMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPD 500
++ K ++ +A ++L + E+ + N+ ++ +
Sbjct: 566 QVKKSWAKQSVALDVLSYHATCSKAEVDKF----KAANIPLVSELA-------------- 607
Query: 501 PRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVT 560
+ + F DF L +I +R+F E+ +V+KFK+ E L RW+ TVRK YR V
Sbjct: 608 -----IDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVL 662
Query: 561 YHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSP 620
YHNWRH FNV Q MF +L T + T++E A++ CHD+DHRGTNN +Q KS S
Sbjct: 663 YHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSA 722
Query: 621 LARLHG-SSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFK 679
LA+L+G S+ LE HH ++ +LQ E NIF NL+ +++ ++ L + +I+ATDL LYF+
Sbjct: 723 LAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFE 782
Query: 680 KRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVAL 739
+RT F ++V E Y ++I +M+MTACDL A+TKPWE+ QVA
Sbjct: 783 RRTEFFELVSKGE----------YDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAE 832
Query: 740 MVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEIT 799
+V +EF+EQGD ER L+ P + DRN++DELP+LQ+ +ID +C +Y+ + + ++
Sbjct: 833 LVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLK 892
Query: 800 PMLSGLQNNRVEWKSL 815
PML + NR +W+ L
Sbjct: 893 PMLDSVATNRSKWEEL 908
>gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]
Length = 683
Score = 387 bits (994), Expect = e-107
Identities = 226/659 (34%), Positives = 351/659 (53%), Gaps = 57/659 (8%)
Query: 160 KNSHFSDFMDKQTGYVTKNLLATPIVVGK-EVLAVIMAVNKV-NASEFSKQDEEVFSKYL 217
K+ F+D +DK TGY TK+LL PI E++ V A+NK+ + F++ DE+V YL
Sbjct: 54 KDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYL 113
Query: 218 NFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERY 277
F I + E RS+ L+ N +FEE TD+E+ K ++ ++ L CER
Sbjct: 114 PFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERC 173
Query: 278 SIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTP 337
S+ LL E + +K + PK E +F + ++ +
Sbjct: 174 SVLLL------EDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSD--------- 218
Query: 338 PADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKE 397
W + + + VA G N+ +A D F + + +G+ I++VL +PI N
Sbjct: 219 ----WLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNH 272
Query: 398 DIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLM 457
I+GVA NR DGKPFD+ D+ + E F G + NT YD++ K ++ +A ++L
Sbjct: 273 QIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLS 332
Query: 458 NQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLT 517
+ E+ + N+ ++ + + + F DF L
Sbjct: 333 YHATCSKAEVDKF----KAANIPLVSELA-------------------IDDIHFDDFSLD 369
Query: 518 EHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTL 577
+I +R+F E+ +V+KFK+ E L RW+ TVRK YR V YHNWRH FNV Q MF +
Sbjct: 370 VDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAM 429
Query: 578 LMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHG-SSILERHHLE 636
L T + T++E A++ CHD+DHRGTNN +Q KS S LA+L+G S+ LE HH
Sbjct: 430 LTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFN 489
Query: 637 YSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQT 696
++ +LQ E NIF NL+ +++ ++ L + +I+ATDL LYF++RT F ++V E
Sbjct: 490 HAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGE---- 545
Query: 697 EEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVL 756
Y ++I +M+MTACDL A+TKPWE+ QVA +V +EF+EQGD ER L
Sbjct: 546 ------YDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLEL 599
Query: 757 QQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSL 815
+ P + DRN++DELP+LQ+ +ID +C +Y+ + + ++ PML + NR +W+ L
Sbjct: 600 KLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 658
>gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]
Length = 875
Score = 377 bits (968), Expect = e-104
Identities = 255/825 (30%), Positives = 419/825 (50%), Gaps = 97/825 (11%)
Query: 24 FDRKLR----------VEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEG 73
FDR LR V L + K Q+P+ + F +E C LL V++
Sbjct: 106 FDRPLRPIVVKDSEGTVSFLSDSEKKEQMPL-TPPRFDH----DEGDQCSRLLELVKDIS 160
Query: 74 GTPEQGV--HRALQRLAHLLQADRCSMFL-CRSRNGIPEVASRLLDVTPTSKFEDNLVGP 130
+ H+ + L+ ADR S+FL C + + SRL DV S E+
Sbjct: 161 SHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEV---S 217
Query: 131 DKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKE- 189
+ + + GIVG A + N+ D ++ F+ +D+ TGY T+++L PI +E
Sbjct: 218 NNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREE 277
Query: 190 VLAVIMAVNKV--NASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYN---IESRRSQILM 244
V+ V A+NK N F+++DE+ F+ YL F I+L H + +Y +E++R+Q+L+
Sbjct: 278 VVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVL---HNAQLYETSLLENKRNQVLL 334
Query: 245 WSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPY 304
A+ +FEE +E K T+ S++ ++ +I ++D F + ++ E+E
Sbjct: 335 DLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKS 394
Query: 305 KGPKTP--DGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMM 362
T D ++N Y Y+ + E + + P + F
Sbjct: 395 SDTLTREHDANKIN-YMYAQYVKNTMEPLNI---------------PDVSKDKRF----- 433
Query: 363 NAPADEYFTFQKGPVDETGWVIKNVLSLPIVN-KKEDIVGVATFYNRKDG-----KPFDE 416
+ T G V++ I+++L PI N KK ++GV N+ + KPF+
Sbjct: 434 -----PWTTENTGNVNQQ--CIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNR 486
Query: 417 HDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEK 476
+DE E F G + NT Y+ + + ++ + E+L A EE +
Sbjct: 487 NDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETR-------- 538
Query: 477 LNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVE 536
+L ++ +P ++ ++ +F FSDF L++ C IR+F ++N+V+
Sbjct: 539 ------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQ 586
Query: 537 KFKVPVEVLTRWMYTVRKGYRA-VTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAM 595
F++ EVL RW+ +V+K YR V YHNWRH FN Q MF L G+++ TDLE A+
Sbjct: 587 NFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILAL 646
Query: 596 LAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNK 655
L AA HD+DHRG NN Y +S PLA+L+ SI+E HH + +L I L+
Sbjct: 647 LIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSI 706
Query: 656 RQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIM 715
+++T + + + AI+ATDLALY K+R F +++ Q E DP +KE+ +
Sbjct: 707 EEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK-NQFNLE---------DPHQKELFL 756
Query: 716 AMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKL 775
AM+MTACDLSAITKPW +Q ++A +VA EF++QGD ER L +P +M+R K++++P +
Sbjct: 757 AMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSM 816
Query: 776 QVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYD 820
QVGFID +C +Y+ + ++ P+L G + NR +W++LA++ +
Sbjct: 817 QVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 861
>gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens]
Length = 823
Score = 377 bits (968), Expect = e-104
Identities = 255/825 (30%), Positives = 419/825 (50%), Gaps = 97/825 (11%)
Query: 24 FDRKLR----------VEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEG 73
FDR LR V L + K Q+P+ + F +E C LL V++
Sbjct: 54 FDRPLRPIVVKDSEGTVSFLSDSEKKEQMPL-TPPRFDH----DEGDQCSRLLELVKDIS 108
Query: 74 GTPEQGV--HRALQRLAHLLQADRCSMFL-CRSRNGIPEVASRLLDVTPTSKFEDNLVGP 130
+ H+ + L+ ADR S+FL C + + SRL DV S E+
Sbjct: 109 SHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEV---S 165
Query: 131 DKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKE- 189
+ + + GIVG A + N+ D ++ F+ +D+ TGY T+++L PI +E
Sbjct: 166 NNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREE 225
Query: 190 VLAVIMAVNKV--NASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYN---IESRRSQILM 244
V+ V A+NK N F+++DE+ F+ YL F I+L H + +Y +E++R+Q+L+
Sbjct: 226 VVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVL---HNAQLYETSLLENKRNQVLL 282
Query: 245 WSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPY 304
A+ +FEE +E K T+ S++ ++ +I ++D F + ++ E+E
Sbjct: 283 DLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKS 342
Query: 305 KGPKTP--DGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMM 362
T D ++N Y Y+ + E + + P + F
Sbjct: 343 SDTLTREHDANKIN-YMYAQYVKNTMEPLNI---------------PDVSKDKRF----- 381
Query: 363 NAPADEYFTFQKGPVDETGWVIKNVLSLPIVN-KKEDIVGVATFYNRKDG-----KPFDE 416
+ T G V++ I+++L PI N KK ++GV N+ + KPF+
Sbjct: 382 -----PWTTENTGNVNQQ--CIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNR 434
Query: 417 HDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEK 476
+DE E F G + NT Y+ + + ++ + E+L A EE +
Sbjct: 435 NDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETR-------- 486
Query: 477 LNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVE 536
+L ++ +P ++ ++ +F FSDF L++ C IR+F ++N+V+
Sbjct: 487 ------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQ 534
Query: 537 KFKVPVEVLTRWMYTVRKGYRA-VTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAM 595
F++ EVL RW+ +V+K YR V YHNWRH FN Q MF L G+++ TDLE A+
Sbjct: 535 NFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILAL 594
Query: 596 LAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNK 655
L AA HD+DHRG NN Y +S PLA+L+ SI+E HH + +L I L+
Sbjct: 595 LIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSI 654
Query: 656 RQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIM 715
+++T + + + AI+ATDLALY K+R F +++ Q E DP +KE+ +
Sbjct: 655 EEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK-NQFNLE---------DPHQKELFL 704
Query: 716 AMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKL 775
AM+MTACDLSAITKPW +Q ++A +VA EF++QGD ER L +P +M+R K++++P +
Sbjct: 705 AMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSM 764
Query: 776 QVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYD 820
QVGFID +C +Y+ + ++ P+L G + NR +W++LA++ +
Sbjct: 765 QVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 809
>gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]
Length = 833
Score = 377 bits (968), Expect = e-104
Identities = 255/825 (30%), Positives = 419/825 (50%), Gaps = 97/825 (11%)
Query: 24 FDRKLR----------VEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEG 73
FDR LR V L + K Q+P+ + F +E C LL V++
Sbjct: 64 FDRPLRPIVVKDSEGTVSFLSDSEKKEQMPL-TPPRFDH----DEGDQCSRLLELVKDIS 118
Query: 74 GTPEQGV--HRALQRLAHLLQADRCSMFL-CRSRNGIPEVASRLLDVTPTSKFEDNLVGP 130
+ H+ + L+ ADR S+FL C + + SRL DV S E+
Sbjct: 119 SHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEV---S 175
Query: 131 DKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKE- 189
+ + + GIVG A + N+ D ++ F+ +D+ TGY T+++L PI +E
Sbjct: 176 NNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREE 235
Query: 190 VLAVIMAVNKV--NASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYN---IESRRSQILM 244
V+ V A+NK N F+++DE+ F+ YL F I+L H + +Y +E++R+Q+L+
Sbjct: 236 VVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVL---HNAQLYETSLLENKRNQVLL 292
Query: 245 WSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPY 304
A+ +FEE +E K T+ S++ ++ +I ++D F + ++ E+E
Sbjct: 293 DLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKS 352
Query: 305 KGPKTP--DGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMM 362
T D ++N Y Y+ + E + + P + F
Sbjct: 353 SDTLTREHDANKIN-YMYAQYVKNTMEPLNI---------------PDVSKDKRF----- 391
Query: 363 NAPADEYFTFQKGPVDETGWVIKNVLSLPIVN-KKEDIVGVATFYNRKDG-----KPFDE 416
+ T G V++ I+++L PI N KK ++GV N+ + KPF+
Sbjct: 392 -----PWTTENTGNVNQQ--CIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNR 444
Query: 417 HDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEK 476
+DE E F G + NT Y+ + + ++ + E+L A EE +
Sbjct: 445 NDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETR-------- 496
Query: 477 LNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVE 536
+L ++ +P ++ ++ +F FSDF L++ C IR+F ++N+V+
Sbjct: 497 ------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQ 544
Query: 537 KFKVPVEVLTRWMYTVRKGYRA-VTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAM 595
F++ EVL RW+ +V+K YR V YHNWRH FN Q MF L G+++ TDLE A+
Sbjct: 545 NFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILAL 604
Query: 596 LAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNK 655
L AA HD+DHRG NN Y +S PLA+L+ SI+E HH + +L I L+
Sbjct: 605 LIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSI 664
Query: 656 RQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIM 715
+++T + + + AI+ATDLALY K+R F +++ Q E DP +KE+ +
Sbjct: 665 EEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK-NQFNLE---------DPHQKELFL 714
Query: 716 AMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKL 775
AM+MTACDLSAITKPW +Q ++A +VA EF++QGD ER L +P +M+R K++++P +
Sbjct: 715 AMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSM 774
Query: 776 QVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYD 820
QVGFID +C +Y+ + ++ P+L G + NR +W++LA++ +
Sbjct: 775 QVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 819
>gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]
Length = 575
Score = 350 bits (897), Expect = 4e-96
Identities = 203/601 (33%), Positives = 316/601 (52%), Gaps = 55/601 (9%)
Query: 216 YLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCE 275
YL F I + E RS+ L+ N +FEE TD+E+ K ++ ++ L CE
Sbjct: 4 YLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCE 63
Query: 276 RYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIP 335
R S+ LL E + +K + PK E +F + ++ +
Sbjct: 64 RCSVLLL------EDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSD------- 110
Query: 336 TPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNK 395
W + + + VA G N+ +A D F + + +G+ I++VL +PI N
Sbjct: 111 ------WLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNS 162
Query: 396 KEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEM 455
I+GVA NR DGKPFD+ D+ + E F G + NT YD++ K ++ +A ++
Sbjct: 163 NHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDV 222
Query: 456 LMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFP 515
L + E+ + N+ ++ + + + F DF
Sbjct: 223 LSYHATCSKAEVDKF----KAANIPLVSELA-------------------IDDIHFDDFS 259
Query: 516 LTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMF 575
L +I +R+F E+ +V+KFK+ E L RW+ TVRK YR V YHNWRH FNV Q MF
Sbjct: 260 LDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMF 319
Query: 576 TLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHG-SSILERHH 634
+L T + T++E A++ CHD+DHRGTNN +Q KS S LA+L+G S+ LE HH
Sbjct: 320 AMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHH 379
Query: 635 LEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQM 694
++ +LQ E NIF NL+ +++ ++ L + +I+ATDL LYF++RT F ++V E
Sbjct: 380 FNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGE-- 437
Query: 695 QTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERT 754
Y ++I +M+MTACDL A+TKPWE+ QVA +V +EF+EQGD ER
Sbjct: 438 --------YDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERL 489
Query: 755 VLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKS 814
L+ P + DRN++DELP+LQ+ +ID +C +Y+ + + ++ PML + NR +W+
Sbjct: 490 ELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEE 549
Query: 815 L 815
L
Sbjct: 550 L 550
>gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens]
Length = 489
Score = 329 bits (843), Expect = 8e-90
Identities = 174/475 (36%), Positives = 268/475 (56%), Gaps = 36/475 (7%)
Query: 342 WTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVG 401
W + + + VA G N+ +A D F + + +G+ I++VL +PI N I+G
Sbjct: 25 WLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNHQIIG 82
Query: 402 VATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTK 461
VA NR DGKPFD+ D+ + E F G + NT YD++ K ++ +A ++L
Sbjct: 83 VAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHAT 142
Query: 462 ATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGL 521
+ E+ + N+ ++ + + + F DF L +
Sbjct: 143 CSKAEVDKF----KAANIPLVSELA-------------------IDDIHFDDFSLDVDAM 179
Query: 522 IKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTG 581
I +R+F E+ +V+KFK+ E L RW+ TVRK YR V YHNWRH FNV Q MF +L T
Sbjct: 180 ITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTA 239
Query: 582 RLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHG-SSILERHHLEYSKT 640
+ T++E A++ CHD+DHRGTNN +Q KS S LA+L+G S+ LE HH ++
Sbjct: 240 GFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVM 299
Query: 641 LLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEA 700
+LQ E NIF NL+ +++ ++ L + +I+ATDL LYF++RT F ++V E
Sbjct: 300 ILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGE-------- 351
Query: 701 IKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQP 760
Y ++I +M+MTACDL A+TKPWE+ QVA +V +EF+EQGD ER L+ P
Sbjct: 352 --YDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTP 409
Query: 761 IPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSL 815
+ DRN++DELP+LQ+ +ID +C +Y+ + + ++ PML + NR +W+ L
Sbjct: 410 SAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 464
>gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens]
Length = 932
Score = 259 bits (661), Expect = 1e-68
Identities = 195/745 (26%), Positives = 342/745 (45%), Gaps = 97/745 (13%)
Query: 82 RALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIG 141
+ LQ L +A RC + L N +++ +++ D ++G +EV FPL G
Sbjct: 239 KVLQYLQQETRASRCCLLLVSEDN--LQLSCKVIG--------DKVLG--EEVSFPLT-G 285
Query: 142 IVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIV--VGKEVLAVIMAVNK 199
+G KK+ + D+ S + G + +L P++ +V+A+ A NK
Sbjct: 286 CLGQVVEDKKSIQLKDL--TSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNK 343
Query: 200 VNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESR---RSQILMWSANKVFEELTD 256
+ F+ +DE V ++ S +L ++ + E + Q L+ A +F L D
Sbjct: 344 LEGDLFTDEDEHVIQHCFHYTSTVLT---STLAFQKEQKLKCECQALLQVAKNLFTHLDD 400
Query: 257 VERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVN 316
V + + R+ N E S+ LLD + K DG V+
Sbjct: 401 VSVLLQEIITEARNLSNAEICSVFLLDQNELVA------------------KVFDGGVVD 442
Query: 317 FYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGP 376
EI++ PAD G+ +VA G I N+ +A A F +G
Sbjct: 443 ---------DESYEIRI----PADQ-----GIAGHVATTGQILNIPDAYAHPLF--YRGV 482
Query: 377 VDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNT 436
D TG+ +N+L PI N+ ++++GVA N+ +G F + DE + + + G S+ ++
Sbjct: 483 DDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHS 542
Query: 437 DTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKE 496
Y K+N+ + R +A EM+M K + +E +L + Q VA +
Sbjct: 543 LLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLH-------------DGIQPVAAIDS 589
Query: 497 DLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGY 556
+ F ++ L E + + ++N + +K+ L R+ V+KGY
Sbjct: 590 NFAS--------FTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGY 641
Query: 557 RAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMK 616
R YHNW H F+V + L L Y D+E FA+ + CHD+DHRGTNN +Q+
Sbjct: 642 RDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVA 701
Query: 617 STSPLARLHGS--SILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDL 674
S S LA L+ S S++ERHH + +L NIF + +++ ++ ++ L I+ATDL
Sbjct: 702 SKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDL 761
Query: 675 ALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQ 734
A + + QK+ + + Y + +++ ++MT+CDLS TK W+
Sbjct: 762 AHHLRIFKDLQKMAE-----------VGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTT 810
Query: 735 SQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRF 794
++A ++ EF+ QGDLE+ + +P+ MMDR K +P+LQ+ F++ + +YK
Sbjct: 811 RKIAELIYKEFFSQGDLEK-AMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQDL 868
Query: 795 HKEITPMLSGLQNNRVEWKSLADEY 819
+ + + +NR W ++ ++
Sbjct: 869 FPKAAELYERVASNREHWTKVSHKF 893
>gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]
Length = 934
Score = 259 bits (661), Expect = 1e-68
Identities = 195/745 (26%), Positives = 342/745 (45%), Gaps = 97/745 (13%)
Query: 82 RALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIG 141
+ LQ L +A RC + L N +++ +++ D ++G +EV FPL G
Sbjct: 241 KVLQYLQQETRASRCCLLLVSEDN--LQLSCKVIG--------DKVLG--EEVSFPLT-G 287
Query: 142 IVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIV--VGKEVLAVIMAVNK 199
+G KK+ + D+ S + G + +L P++ +V+A+ A NK
Sbjct: 288 CLGQVVEDKKSIQLKDL--TSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNK 345
Query: 200 VNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESR---RSQILMWSANKVFEELTD 256
+ F+ +DE V ++ S +L ++ + E + Q L+ A +F L D
Sbjct: 346 LEGDLFTDEDEHVIQHCFHYTSTVLT---STLAFQKEQKLKCECQALLQVAKNLFTHLDD 402
Query: 257 VERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVN 316
V + + R+ N E S+ LLD + K DG V+
Sbjct: 403 VSVLLQEIITEARNLSNAEICSVFLLDQNELVA------------------KVFDGGVVD 444
Query: 317 FYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGP 376
EI++ PAD G+ +VA G I N+ +A A F +G
Sbjct: 445 ---------DESYEIRI----PADQ-----GIAGHVATTGQILNIPDAYAHPLF--YRGV 484
Query: 377 VDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNT 436
D TG+ +N+L PI N+ ++++GVA N+ +G F + DE + + + G S+ ++
Sbjct: 485 DDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHS 544
Query: 437 DTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKE 496
Y K+N+ + R +A EM+M K + +E +L + Q VA +
Sbjct: 545 LLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLH-------------DGIQPVAAIDS 591
Query: 497 DLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGY 556
+ F ++ L E + + ++N + +K+ L R+ V+KGY
Sbjct: 592 NFAS--------FTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGY 643
Query: 557 RAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMK 616
R YHNW H F+V + L L Y D+E FA+ + CHD+DHRGTNN +Q+
Sbjct: 644 RDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVA 703
Query: 617 STSPLARLHGS--SILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDL 674
S S LA L+ S S++ERHH + +L NIF + +++ ++ ++ L I+ATDL
Sbjct: 704 SKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDL 763
Query: 675 ALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQ 734
A + + QK+ + + Y + +++ ++MT+CDLS TK W+
Sbjct: 764 AHHLRIFKDLQKMAE-----------VGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTT 812
Query: 735 SQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRF 794
++A ++ EF+ QGDLE+ + +P+ MMDR K +P+LQ+ F++ + +YK
Sbjct: 813 RKIAELIYKEFFSQGDLEK-AMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQDL 870
Query: 795 HKEITPMLSGLQNNRVEWKSLADEY 819
+ + + +NR W ++ ++
Sbjct: 871 FPKAAELYERVASNREHWTKVSHKF 895
>gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]
Length = 941
Score = 259 bits (661), Expect = 1e-68
Identities = 195/745 (26%), Positives = 342/745 (45%), Gaps = 97/745 (13%)
Query: 82 RALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIG 141
+ LQ L +A RC + L N +++ +++ D ++G +EV FPL G
Sbjct: 248 KVLQYLQQETRASRCCLLLVSEDN--LQLSCKVIG--------DKVLG--EEVSFPLT-G 294
Query: 142 IVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIV--VGKEVLAVIMAVNK 199
+G KK+ + D+ S + G + +L P++ +V+A+ A NK
Sbjct: 295 CLGQVVEDKKSIQLKDL--TSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNK 352
Query: 200 VNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESR---RSQILMWSANKVFEELTD 256
+ F+ +DE V ++ S +L ++ + E + Q L+ A +F L D
Sbjct: 353 LEGDLFTDEDEHVIQHCFHYTSTVLT---STLAFQKEQKLKCECQALLQVAKNLFTHLDD 409
Query: 257 VERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVN 316
V + + R+ N E S+ LLD + K DG V+
Sbjct: 410 VSVLLQEIITEARNLSNAEICSVFLLDQNELVA------------------KVFDGGVVD 451
Query: 317 FYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGP 376
EI++ PAD G+ +VA G I N+ +A A F +G
Sbjct: 452 ---------DESYEIRI----PADQ-----GIAGHVATTGQILNIPDAYAHPLF--YRGV 491
Query: 377 VDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNT 436
D TG+ +N+L PI N+ ++++GVA N+ +G F + DE + + + G S+ ++
Sbjct: 492 DDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHS 551
Query: 437 DTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKE 496
Y K+N+ + R +A EM+M K + +E +L + Q VA +
Sbjct: 552 LLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLH-------------DGIQPVAAIDS 598
Query: 497 DLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGY 556
+ F ++ L E + + ++N + +K+ L R+ V+KGY
Sbjct: 599 NFAS--------FTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGY 650
Query: 557 RAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMK 616
R YHNW H F+V + L L Y D+E FA+ + CHD+DHRGTNN +Q+
Sbjct: 651 RDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVA 710
Query: 617 STSPLARLHGS--SILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDL 674
S S LA L+ S S++ERHH + +L NIF + +++ ++ ++ L I+ATDL
Sbjct: 711 SKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDL 770
Query: 675 ALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQ 734
A + + QK+ + + Y + +++ ++MT+CDLS TK W+
Sbjct: 771 AHHLRIFKDLQKMAE-----------VGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTT 819
Query: 735 SQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRF 794
++A ++ EF+ QGDLE+ + +P+ MMDR K +P+LQ+ F++ + +YK
Sbjct: 820 RKIAELIYKEFFSQGDLEK-AMGNRPMEMMDREKA-YIPELQISFMEHIAMPIYKLLQDL 877
Query: 795 HKEITPMLSGLQNNRVEWKSLADEY 819
+ + + +NR W ++ ++
Sbjct: 878 FPKAAELYERVASNREHWTKVSHKF 902
>gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]
Length = 779
Score = 238 bits (607), Expect = 2e-62
Identities = 202/830 (24%), Positives = 358/830 (43%), Gaps = 116/830 (13%)
Query: 9 VEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEES---ALCLEL 65
V+ YL +PQ E+ + E + + K + + E+++ +++ + EL
Sbjct: 19 VKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYEL 78
Query: 66 LWTVQEE---GGTPEQGVHRALQRLAHLLQADRCSMFLCRSRN---------GIPEVASR 113
+++ GG + ++ + +AD +++ N GI E R
Sbjct: 79 NSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPR 138
Query: 114 LLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTG 173
L+ P ++ + + A ++KT V D+ + F ++G
Sbjct: 139 LIPAGPITQ----------------GTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESG 182
Query: 174 YVTKNLLATPIVVG-KEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYM 232
+++L PIV +++ ++ F +EV + L + S+ +
Sbjct: 183 TRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRG 242
Query: 233 YNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYD 292
++ + L+ + F+ + ++ + ++ +N +R ++ +D K KE Y
Sbjct: 243 LAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDH-KNKELYS 301
Query: 293 EWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYV 352
+ +GE + K P +E+ F ++ G+ V
Sbjct: 302 DL-FDIGEEKEGK-PVFKKTKEIRF-------------------------SIEKGIAGQV 334
Query: 353 AENGFICNMMNAPADEYFTFQKGPVD-ETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDG 411
A G + N+ +A AD F + VD TG+ +N+L +PIV++ ++GV N+ G
Sbjct: 335 ARTGEVLNIPDAYADPRFNRE---VDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKISG 390
Query: 412 KPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSIL 471
F + DE + F +L + Y ++ E + E L + T EE + ++
Sbjct: 391 SAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM 450
Query: 472 KFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLI------KCG 525
+F + + C+E EL+ F F G+ CG
Sbjct: 451 QFTLPVRL-----CKE----------------IELFHFDIGPFENMWPGIFVYMVHRSCG 489
Query: 526 IRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKK 585
F +E L R++ +V+K YR V YHNW+H V M+ +L
Sbjct: 490 TSCF-----------ELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHT-- 536
Query: 586 YYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDE 645
+TDLE +L A CHD+DHRG +N Y K PLA L+ +S +E+HH + ++LQ E
Sbjct: 537 LFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE 596
Query: 646 SLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVT 705
NIF L+ ++E V+ + AIIATDLALYF R + E QT +
Sbjct: 597 GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLE------EMYQTGSLNLN--- 647
Query: 706 VDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMD 765
+ + ++ ++ +MMTACDL ++TK W V A + EFW +GD E L QPIPMMD
Sbjct: 648 -NQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMD 705
Query: 766 RNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSL 815
R+K+DE+P+ Q+GF + V Y ++ P+L ++N +W+ +
Sbjct: 706 RDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKV 755
>gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]
Length = 789
Score = 238 bits (607), Expect = 2e-62
Identities = 202/830 (24%), Positives = 358/830 (43%), Gaps = 116/830 (13%)
Query: 9 VEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEES---ALCLEL 65
V+ YL +PQ E+ + E + + K + + E+++ +++ + EL
Sbjct: 29 VKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYEL 88
Query: 66 LWTVQEE---GGTPEQGVHRALQRLAHLLQADRCSMFLCRSRN---------GIPEVASR 113
+++ GG + ++ + +AD +++ N GI E R
Sbjct: 89 NSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPR 148
Query: 114 LLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTG 173
L+ P ++ + + A ++KT V D+ + F ++G
Sbjct: 149 LIPAGPITQ----------------GTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESG 192
Query: 174 YVTKNLLATPIVVG-KEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYM 232
+++L PIV +++ ++ F +EV + L + S+ +
Sbjct: 193 TRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRG 252
Query: 233 YNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYD 292
++ + L+ + F+ + ++ + ++ +N +R ++ +D K KE Y
Sbjct: 253 LAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDH-KNKELYS 311
Query: 293 EWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYV 352
+ +GE + K P +E+ F ++ G+ V
Sbjct: 312 DL-FDIGEEKEGK-PVFKKTKEIRF-------------------------SIEKGIAGQV 344
Query: 353 AENGFICNMMNAPADEYFTFQKGPVD-ETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDG 411
A G + N+ +A AD F + VD TG+ +N+L +PIV++ ++GV N+ G
Sbjct: 345 ARTGEVLNIPDAYADPRFNRE---VDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKISG 400
Query: 412 KPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSIL 471
F + DE + F +L + Y ++ E + E L + T EE + ++
Sbjct: 401 SAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM 460
Query: 472 KFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLI------KCG 525
+F + + C+E EL+ F F G+ CG
Sbjct: 461 QFTLPVRL-----CKE----------------IELFHFDIGPFENMWPGIFVYMVHRSCG 499
Query: 526 IRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKK 585
F +E L R++ +V+K YR V YHNW+H V M+ +L
Sbjct: 500 TSCF-----------ELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHT-- 546
Query: 586 YYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDE 645
+TDLE +L A CHD+DHRG +N Y K PLA L+ +S +E+HH + ++LQ E
Sbjct: 547 LFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE 606
Query: 646 SLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVT 705
NIF L+ ++E V+ + AIIATDLALYF R + E QT +
Sbjct: 607 GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLE------EMYQTGSLNLN--- 657
Query: 706 VDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMD 765
+ + ++ ++ +MMTACDL ++TK W V A + EFW +GD E L QPIPMMD
Sbjct: 658 -NQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMD 715
Query: 766 RNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSL 815
R+K+DE+P+ Q+GF + V Y ++ P+L ++N +W+ +
Sbjct: 716 RDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKV 765
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 141 bits (356), Expect = 2e-33
Identities = 108/369 (29%), Positives = 187/369 (50%), Gaps = 21/369 (5%)
Query: 493 ILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTV 552
+L ++L D L+ FR ++ L +F E ++++ FK+PV+ L ++ T+
Sbjct: 393 VLAKELEDVNKWGLHVFRIAELS-GNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTL 451
Query: 553 RKGYRA-VTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNN 611
Y A V YHN H +V Q+ LL T L+ +TDLE A + A+ HD+DH G +N
Sbjct: 452 EDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSN 511
Query: 612 LYQMKSTSPLARLHG-SSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAII 670
+ + + S LA ++ SS+LE HHL LLQ+E+ +IFQNL K+Q +++ + ++
Sbjct: 512 QFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVL 571
Query: 671 ATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAM--MMTACDLSAIT 728
ATD++ + + D ++T++ V + + I + M+ DLS T
Sbjct: 572 ATDMSKH------MNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPT 625
Query: 729 KPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVY 788
KP ++ Q + EF+ QGD ER + PM D++ + K QVGFID++ ++
Sbjct: 626 KPLQLYRQWTDRIMEEFFRQGDRERE-RGMEISPMCDKHNA-SVEKSQVGFIDYIVHPLW 683
Query: 789 KEFSRF-HKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEK-----AAE 842
+ ++ H + +L L++NR ++S + + EE + +G EK E
Sbjct: 684 ETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGR--QGQTEKFQFELTLE 741
Query: 843 DSGGGDDKK 851
+ G D +K
Sbjct: 742 EDGESDTEK 750
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 141 bits (356), Expect = 2e-33
Identities = 108/369 (29%), Positives = 187/369 (50%), Gaps = 21/369 (5%)
Query: 493 ILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTV 552
+L ++L D L+ FR ++ L +F E ++++ FK+PV+ L ++ T+
Sbjct: 257 VLAKELEDVNKWGLHVFRIAELS-GNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTL 315
Query: 553 RKGYRA-VTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNN 611
Y A V YHN H +V Q+ LL T L+ +TDLE A + A+ HD+DH G +N
Sbjct: 316 EDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSN 375
Query: 612 LYQMKSTSPLARLHG-SSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAII 670
+ + + S LA ++ SS+LE HHL LLQ+E+ +IFQNL K+Q +++ + ++
Sbjct: 376 QFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVL 435
Query: 671 ATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAM--MMTACDLSAIT 728
ATD++ + + D ++T++ V + + I + M+ DLS T
Sbjct: 436 ATDMSKH------MNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPT 489
Query: 729 KPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVY 788
KP ++ Q + EF+ QGD ER + PM D++ + K QVGFID++ ++
Sbjct: 490 KPLQLYRQWTDRIMEEFFRQGDRERE-RGMEISPMCDKHNA-SVEKSQVGFIDYIVHPLW 547
Query: 789 KEFSRF-HKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEK-----AAE 842
+ ++ H + +L L++NR ++S + + EE + +G EK E
Sbjct: 548 ETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGR--QGQTEKFQFELTLE 605
Query: 843 DSGGGDDKK 851
+ G D +K
Sbjct: 606 EDGESDTEK 614
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 141 bits (355), Expect = 3e-33
Identities = 95/289 (32%), Positives = 159/289 (55%), Gaps = 12/289 (4%)
Query: 528 LFFEINVVEKFKVPVEVLTRWMYTVRKGYRA-VTYHNWRHGFNVGQTMFTLLMTGRLKKY 586
+F E ++++KF++PV+ + +M T+ Y A V YHN H +V Q+ LL T L
Sbjct: 337 IFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAV 396
Query: 587 YTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHG-SSILERHHLEYSKTLLQDE 645
+TDLE A L AA HD+DH G +N + + + S LA ++ S+LE HHL LLQ++
Sbjct: 397 FTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED 456
Query: 646 SLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVT 705
+ +IFQNL+KRQ +++ + ++ATD++ K T+ + E + + +
Sbjct: 457 NCDIFQNLSKRQRQSLRKMVIDMVLATDMS---KHMTLLADLKTMVETKKVTSSGV--LL 511
Query: 706 VDPTKKEI-IMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMM 764
+D I ++ M+ DLS TKP E+ Q + EF++QGD ER + PM
Sbjct: 512 LDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMC 570
Query: 765 DRNKRDELPKLQVGFIDFVCTFVYKEFSRF-HKEITPMLSGLQNNRVEW 812
D++ + K QVGFID++ +++ ++ H + +L L++NR +W
Sbjct: 571 DKHTA-SVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNR-DW 617
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 141 bits (355), Expect = 3e-33
Identities = 95/289 (32%), Positives = 159/289 (55%), Gaps = 12/289 (4%)
Query: 528 LFFEINVVEKFKVPVEVLTRWMYTVRKGYRA-VTYHNWRHGFNVGQTMFTLLMTGRLKKY 586
+F E ++++KF++PV+ + +M T+ Y A V YHN H +V Q+ LL T L
Sbjct: 372 IFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAV 431
Query: 587 YTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHG-SSILERHHLEYSKTLLQDE 645
+TDLE A L AA HD+DH G +N + + + S LA ++ S+LE HHL LLQ++
Sbjct: 432 FTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED 491
Query: 646 SLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVT 705
+ +IFQNL+KRQ +++ + ++ATD++ K T+ + E + + +
Sbjct: 492 NCDIFQNLSKRQRQSLRKMVIDMVLATDMS---KHMTLLADLKTMVETKKVTSSGV--LL 546
Query: 706 VDPTKKEI-IMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMM 764
+D I ++ M+ DLS TKP E+ Q + EF++QGD ER + PM
Sbjct: 547 LDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMC 605
Query: 765 DRNKRDELPKLQVGFIDFVCTFVYKEFSRF-HKEITPMLSGLQNNRVEW 812
D++ + K QVGFID++ +++ ++ H + +L L++NR +W
Sbjct: 606 DKHTA-SVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNR-DW 652
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 141 bits (355), Expect = 3e-33
Identities = 95/289 (32%), Positives = 159/289 (55%), Gaps = 12/289 (4%)
Query: 528 LFFEINVVEKFKVPVEVLTRWMYTVRKGYRA-VTYHNWRHGFNVGQTMFTLLMTGRLKKY 586
+F E ++++KF++PV+ + +M T+ Y A V YHN H +V Q+ LL T L
Sbjct: 398 IFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAV 457
Query: 587 YTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHG-SSILERHHLEYSKTLLQDE 645
+TDLE A L AA HD+DH G +N + + + S LA ++ S+LE HHL LLQ++
Sbjct: 458 FTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED 517
Query: 646 SLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVT 705
+ +IFQNL+KRQ +++ + ++ATD++ K T+ + E + + +
Sbjct: 518 NCDIFQNLSKRQRQSLRKMVIDMVLATDMS---KHMTLLADLKTMVETKKVTSSGV--LL 572
Query: 706 VDPTKKEI-IMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMM 764
+D I ++ M+ DLS TKP E+ Q + EF++QGD ER + PM
Sbjct: 573 LDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMC 631
Query: 765 DRNKRDELPKLQVGFIDFVCTFVYKEFSRF-HKEITPMLSGLQNNRVEW 812
D++ + K QVGFID++ +++ ++ H + +L L++NR +W
Sbjct: 632 DKHTA-SVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNR-DW 678
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 141 bits (355), Expect = 3e-33
Identities = 95/289 (32%), Positives = 159/289 (55%), Gaps = 12/289 (4%)
Query: 528 LFFEINVVEKFKVPVEVLTRWMYTVRKGYRA-VTYHNWRHGFNVGQTMFTLLMTGRLKKY 586
+F E ++++KF++PV+ + +M T+ Y A V YHN H +V Q+ LL T L
Sbjct: 159 IFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAV 218
Query: 587 YTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHG-SSILERHHLEYSKTLLQDE 645
+TDLE A L AA HD+DH G +N + + + S LA ++ S+LE HHL LLQ++
Sbjct: 219 FTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED 278
Query: 646 SLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVT 705
+ +IFQNL+KRQ +++ + ++ATD++ K T+ + E + + +
Sbjct: 279 NCDIFQNLSKRQRQSLRKMVIDMVLATDMS---KHMTLLADLKTMVETKKVTSSGV--LL 333
Query: 706 VDPTKKEI-IMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMM 764
+D I ++ M+ DLS TKP E+ Q + EF++QGD ER + PM
Sbjct: 334 LDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMC 392
Query: 765 DRNKRDELPKLQVGFIDFVCTFVYKEFSRF-HKEITPMLSGLQNNRVEW 812
D++ + K QVGFID++ +++ ++ H + +L L++NR +W
Sbjct: 393 DKHTA-SVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNR-DW 439
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 129 bits (323), Expect = 2e-29
Identities = 85/327 (25%), Positives = 159/327 (48%), Gaps = 18/327 (5%)
Query: 521 LIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMT 580
++ C ++ ++ +V F + L RW++ V YR +HN+RH F V Q M++++
Sbjct: 64 MLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWL 123
Query: 581 GRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLA-RLHGSSILERHHLEYSK 639
L++ ++ + ++ AA CHD+DH G NN YQ+ + + LA R + S LE HH +
Sbjct: 124 CSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAF 183
Query: 640 TLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEE 699
+L + NIF N+ F+ + I+ATD+A + + F++ ++ + E
Sbjct: 184 QILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEH- 242
Query: 700 AIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQ 759
++ +++ CD+S +P EV + E++ Q D E++ +
Sbjct: 243 -----------MTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EGL 289
Query: 760 PI-PMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITP-MLSGLQNNRVEWKSLAD 817
P+ P MDR+K + Q+GFI FV +++ ++ + ML L +R ++ L
Sbjct: 290 PVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKR 348
Query: 818 EYDAKMKVIEEEAKKQEGGAEKAAEDS 844
DA ++ ++ G EK+ E S
Sbjct: 349 IDDAMKELQKKTDSLTSGATEKSRERS 375
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 129 bits (323), Expect = 2e-29
Identities = 85/327 (25%), Positives = 159/327 (48%), Gaps = 18/327 (5%)
Query: 521 LIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMT 580
++ C ++ ++ +V F + L RW++ V YR +HN+RH F V Q M++++
Sbjct: 64 MLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWL 123
Query: 581 GRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLA-RLHGSSILERHHLEYSK 639
L++ ++ + ++ AA CHD+DH G NN YQ+ + + LA R + S LE HH +
Sbjct: 124 CSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAF 183
Query: 640 TLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEE 699
+L + NIF N+ F+ + I+ATD+A + + F++ ++ + E
Sbjct: 184 QILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEH- 242
Query: 700 AIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQ 759
++ +++ CD+S +P EV + E++ Q D E++ +
Sbjct: 243 -----------MTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EGL 289
Query: 760 PI-PMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITP-MLSGLQNNRVEWKSLAD 817
P+ P MDR+K + Q+GFI FV +++ ++ + ML L +R ++ L
Sbjct: 290 PVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKR 348
Query: 818 EYDAKMKVIEEEAKKQEGGAEKAAEDS 844
DA ++ ++ G EK+ E S
Sbjct: 349 IDDAMKELQKKTDSLTSGATEKSRERS 375
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 129 bits (323), Expect = 2e-29
Identities = 85/327 (25%), Positives = 159/327 (48%), Gaps = 18/327 (5%)
Query: 521 LIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMT 580
++ C ++ ++ +V F + L RW++ V YR +HN+RH F V Q M++++
Sbjct: 245 MLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWL 304
Query: 581 GRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLA-RLHGSSILERHHLEYSK 639
L++ ++ + ++ AA CHD+DH G NN YQ+ + + LA R + S LE HH +
Sbjct: 305 CSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAF 364
Query: 640 TLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEE 699
+L + NIF N+ F+ + I+ATD+A + + F++ ++ + E
Sbjct: 365 QILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEH- 423
Query: 700 AIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQ 759
++ +++ CD+S +P EV + E++ Q D E++ +
Sbjct: 424 -----------MTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EGL 470
Query: 760 PI-PMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITP-MLSGLQNNRVEWKSLAD 817
P+ P MDR+K + Q+GFI FV +++ ++ + ML L +R ++ L
Sbjct: 471 PVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKR 529
Query: 818 EYDAKMKVIEEEAKKQEGGAEKAAEDS 844
DA ++ ++ G EK+ E S
Sbjct: 530 IDDAMKELQKKTDSLTSGATEKSRERS 556
>gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]
Length = 552
Score = 129 bits (323), Expect = 2e-29
Identities = 85/327 (25%), Positives = 159/327 (48%), Gaps = 18/327 (5%)
Query: 521 LIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMT 580
++ C ++ ++ +V F + L RW++ V YR +HN+RH F V Q M++++
Sbjct: 230 MLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWL 289
Query: 581 GRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLA-RLHGSSILERHHLEYSK 639
L++ ++ + ++ AA CHD+DH G NN YQ+ + + LA R + S LE HH +
Sbjct: 290 CSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAF 349
Query: 640 TLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEE 699
+L + NIF N+ F+ + I+ATD+A + + F++ ++ + E
Sbjct: 350 QILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEH- 408
Query: 700 AIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQ 759
++ +++ CD+S +P EV + E++ Q D E++ +
Sbjct: 409 -----------MTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EGL 455
Query: 760 PI-PMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITP-MLSGLQNNRVEWKSLAD 817
P+ P MDR+K + Q+GFI FV +++ ++ + ML L +R ++ L
Sbjct: 456 PVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKR 514
Query: 818 EYDAKMKVIEEEAKKQEGGAEKAAEDS 844
DA ++ ++ G EK+ E S
Sbjct: 515 IDDAMKELQKKTDSLTSGATEKSRERS 541
>gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens]
Length = 526
Score = 129 bits (323), Expect = 2e-29
Identities = 85/327 (25%), Positives = 159/327 (48%), Gaps = 18/327 (5%)
Query: 521 LIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMT 580
++ C ++ ++ +V F + L RW++ V YR +HN+RH F V Q M++++
Sbjct: 204 MLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWL 263
Query: 581 GRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLA-RLHGSSILERHHLEYSK 639
L++ ++ + ++ AA CHD+DH G NN YQ+ + + LA R + S LE HH +
Sbjct: 264 CSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAF 323
Query: 640 TLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEE 699
+L + NIF N+ F+ + I+ATD+A + + F++ ++ + E
Sbjct: 324 QILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEH- 382
Query: 700 AIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQ 759
++ +++ CD+S +P EV + E++ Q D E++ +
Sbjct: 383 -----------MTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EGL 429
Query: 760 PI-PMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITP-MLSGLQNNRVEWKSLAD 817
P+ P MDR+K + Q+GFI FV +++ ++ + ML L +R ++ L
Sbjct: 430 PVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKR 488
Query: 818 EYDAKMKVIEEEAKKQEGGAEKAAEDS 844
DA ++ ++ G EK+ E S
Sbjct: 489 IDDAMKELQKKTDSLTSGATEKSRERS 515
>gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens]
Length = 376
Score = 129 bits (323), Expect = 2e-29
Identities = 85/327 (25%), Positives = 159/327 (48%), Gaps = 18/327 (5%)
Query: 521 LIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMT 580
++ C ++ ++ +V F + L RW++ V YR +HN+RH F V Q M++++
Sbjct: 54 MLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWL 113
Query: 581 GRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLA-RLHGSSILERHHLEYSK 639
L++ ++ + ++ AA CHD+DH G NN YQ+ + + LA R + S LE HH +
Sbjct: 114 CSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAF 173
Query: 640 TLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEE 699
+L + NIF N+ F+ + I+ATD+A + + F++ ++ + E
Sbjct: 174 QILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEH- 232
Query: 700 AIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQ 759
++ +++ CD+S +P EV + E++ Q D E++ +
Sbjct: 233 -----------MTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EGL 279
Query: 760 PI-PMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITP-MLSGLQNNRVEWKSLAD 817
P+ P MDR+K + Q+GFI FV +++ ++ + ML L +R ++ L
Sbjct: 280 PVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKR 338
Query: 818 EYDAKMKVIEEEAKKQEGGAEKAAEDS 844
DA ++ ++ G EK+ E S
Sbjct: 339 IDDAMKELQKKTDSLTSGATEKSRERS 365
>gi|48762742 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 129 bits (323), Expect = 2e-29
Identities = 85/327 (25%), Positives = 159/327 (48%), Gaps = 18/327 (5%)
Query: 521 LIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMT 580
++ C ++ ++ +V F + L RW++ V YR +HN+RH F V Q M++++
Sbjct: 64 MLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWL 123
Query: 581 GRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLA-RLHGSSILERHHLEYSK 639
L++ ++ + ++ AA CHD+DH G NN YQ+ + + LA R + S LE HH +
Sbjct: 124 CSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAF 183
Query: 640 TLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEE 699
+L + NIF N+ F+ + I+ATD+A + + F++ ++ + E
Sbjct: 184 QILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEH- 242
Query: 700 AIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQ 759
++ +++ CD+S +P EV + E++ Q D E++ +
Sbjct: 243 -----------MTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EGL 289
Query: 760 PI-PMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITP-MLSGLQNNRVEWKSLAD 817
P+ P MDR+K + Q+GFI FV +++ ++ + ML L +R ++ L
Sbjct: 290 PVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKR 348
Query: 818 EYDAKMKVIEEEAKKQEGGAEKAAEDS 844
DA ++ ++ G EK+ E S
Sbjct: 349 IDDAMKELQKKTDSLTSGATEKSRERS 375
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,491,403
Number of Sequences: 37866
Number of extensions: 1414342
Number of successful extensions: 4210
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 3912
Number of HSP's gapped (non-prelim): 102
length of query: 858
length of database: 18,247,518
effective HSP length: 111
effective length of query: 747
effective length of database: 14,044,392
effective search space: 10491160824
effective search space used: 10491160824
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.