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Search of human proteins with 157311604
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157311604 phosphodiesterase 4D interacting protein isoform 1
[Homo sapiens]
(2346 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157311604 phosphodiesterase 4D interacting protein isoform 1 ... 4531 0.0
gi|50658069 phosphodiesterase 4D interacting protein isoform 2 [... 1851 0.0
gi|50658071 phosphodiesterase 4D interacting protein isoform 5 [... 1447 0.0
gi|169217962 PREDICTED: similar to phosphodiesterase 4D interact... 825 0.0
gi|239752897 PREDICTED: similar to phosphodiesterase 4D interact... 393 e-108
gi|169217489 PREDICTED: similar to phosphodiesterase 4D interact... 380 e-104
gi|239747450 PREDICTED: similar to phosphodiesterase 4D interact... 379 e-104
gi|50658077 phosphodiesterase 4D interacting protein isoform 4 [... 343 1e-93
gi|50658075 phosphodiesterase 4D interacting protein isoform 3 [... 325 3e-88
gi|88943074 PREDICTED: similar to Phosphodiesterase 4D interacti... 248 4e-65
gi|58535453 CDK5 regulatory subunit associated protein 2 isoform... 226 3e-58
gi|58535451 CDK5 regulatory subunit associated protein 2 isoform... 226 3e-58
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 169 4e-41
gi|55770834 centromere protein F [Homo sapiens] 158 7e-38
gi|21735548 centrosomal protein 2 [Homo sapiens] 157 2e-37
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 146 2e-34
gi|71061468 centromere protein E [Homo sapiens] 145 3e-34
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 145 5e-34
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 144 1e-33
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 143 2e-33
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 139 2e-32
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 139 4e-32
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 138 7e-32
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 137 9e-32
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 136 2e-31
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 136 2e-31
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 136 3e-31
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 136 3e-31
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 135 5e-31
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 135 5e-31
>gi|157311604 phosphodiesterase 4D interacting protein isoform 1 [Homo
sapiens]
Length = 2346
Score = 4531 bits (11753), Expect = 0.0
Identities = 2346/2346 (100%), Positives = 2346/2346 (100%)
Query: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR 60
MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR
Sbjct: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR 60
Query: 61 ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK 120
ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK
Sbjct: 61 ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK 120
Query: 121 NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQ 180
NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQ
Sbjct: 121 NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQ 180
Query: 181 SLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSH 240
SLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSH
Sbjct: 181 SLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSH 240
Query: 241 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 300
LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL
Sbjct: 241 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 300
Query: 301 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 360
YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR
Sbjct: 301 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 360
Query: 361 VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA 420
VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA
Sbjct: 361 VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA 420
Query: 421 WEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR 480
WEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR
Sbjct: 421 WEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR 480
Query: 481 IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL 540
IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL
Sbjct: 481 IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL 540
Query: 541 LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSAT 600
LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSAT
Sbjct: 541 LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSAT 600
Query: 601 LLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQ 660
LLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQ
Sbjct: 601 LLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQ 660
Query: 661 AAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQI 720
AAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQI
Sbjct: 661 AAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQI 720
Query: 721 PSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQ 780
PSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQ
Sbjct: 721 PSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQ 780
Query: 781 SMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREK 840
SMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREK
Sbjct: 781 SMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREK 840
Query: 841 VASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD 900
VASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD
Sbjct: 841 VASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD 900
Query: 901 RTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE 960
RTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE
Sbjct: 901 RTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE 960
Query: 961 AAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEK 1020
AAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEK
Sbjct: 961 AAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEK 1020
Query: 1021 RKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKG 1080
RKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKG
Sbjct: 1021 RKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKG 1080
Query: 1081 EVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLV 1140
EVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLV
Sbjct: 1081 EVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLV 1140
Query: 1141 HLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRD 1200
HLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRD
Sbjct: 1141 HLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRD 1200
Query: 1201 PGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESL 1260
PGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESL
Sbjct: 1201 PGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESL 1260
Query: 1261 VKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRG 1320
VKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRG
Sbjct: 1261 VKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRG 1320
Query: 1321 STLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVR 1380
STLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVR
Sbjct: 1321 STLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVR 1380
Query: 1381 SLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLES 1440
SLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLES
Sbjct: 1381 SLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLES 1440
Query: 1441 LIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICY 1500
LIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICY
Sbjct: 1441 LIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICY 1500
Query: 1501 LITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQA 1560
LITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQA
Sbjct: 1501 LITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQA 1560
Query: 1561 GLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEAC 1620
GLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEAC
Sbjct: 1561 GLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEAC 1620
Query: 1621 SDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPT 1680
SDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPT
Sbjct: 1621 SDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPT 1680
Query: 1681 PQNTPKEANQAHSGFHFHSIPKLASLPQAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLA 1740
PQNTPKEANQAHSGFHFHSIPKLASLPQAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLA
Sbjct: 1681 PQNTPKEANQAHSGFHFHSIPKLASLPQAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLA 1740
Query: 1741 EAQQELQMLQKQLGESASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRIL 1800
EAQQELQMLQKQLGESASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRIL
Sbjct: 1741 EAQQELQMLQKQLGESASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRIL 1800
Query: 1801 EPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEE 1860
EPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEE
Sbjct: 1801 EPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEE 1860
Query: 1861 SICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSH 1920
SICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSH
Sbjct: 1861 SICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSH 1920
Query: 1921 VSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLS 1980
VSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLS
Sbjct: 1921 VSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLS 1980
Query: 1981 LQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPL 2040
LQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPL
Sbjct: 1981 LQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPL 2040
Query: 2041 SSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQNFPASTDP 2100
SSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQNFPASTDP
Sbjct: 2041 SSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQNFPASTDP 2100
Query: 2101 GNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDTSPVMKTP 2160
GNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDTSPVMKTP
Sbjct: 2101 GNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDTSPVMKTP 2160
Query: 2161 PKLEGDATDGSFANKHGRHVIGHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQ 2220
PKLEGDATDGSFANKHGRHVIGHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQ
Sbjct: 2161 PKLEGDATDGSFANKHGRHVIGHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQ 2220
Query: 2221 GTEVLGSKGIHELRSSTSALHHALEESASLLTMFWRAALPSTHIPVLPGKVGESTERELL 2280
GTEVLGSKGIHELRSSTSALHHALEESASLLTMFWRAALPSTHIPVLPGKVGESTERELL
Sbjct: 2221 GTEVLGSKGIHELRSSTSALHHALEESASLLTMFWRAALPSTHIPVLPGKVGESTERELL 2280
Query: 2281 ELRTKVSKQERLLQSTTEHLKNANQQKESMEQFIVSQLTRTHDVLKKARTNLEVKSLRAL 2340
ELRTKVSKQERLLQSTTEHLKNANQQKESMEQFIVSQLTRTHDVLKKARTNLEVKSLRAL
Sbjct: 2281 ELRTKVSKQERLLQSTTEHLKNANQQKESMEQFIVSQLTRTHDVLKKARTNLEVKSLRAL 2340
Query: 2341 PCTPAL 2346
PCTPAL
Sbjct: 2341 PCTPAL 2346
>gi|50658069 phosphodiesterase 4D interacting protein isoform 2
[Homo sapiens]
Length = 969
Score = 1851 bits (4795), Expect = 0.0
Identities = 969/969 (100%), Positives = 969/969 (100%)
Query: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR 60
MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR
Sbjct: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR 60
Query: 61 ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK 120
ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK
Sbjct: 61 ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK 120
Query: 121 NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQ 180
NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQ
Sbjct: 121 NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQ 180
Query: 181 SLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSH 240
SLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSH
Sbjct: 181 SLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSH 240
Query: 241 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 300
LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL
Sbjct: 241 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL 300
Query: 301 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 360
YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR
Sbjct: 301 YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQR 360
Query: 361 VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA 420
VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA
Sbjct: 361 VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRA 420
Query: 421 WEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR 480
WEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR
Sbjct: 421 WEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR 480
Query: 481 IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL 540
IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL
Sbjct: 481 IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL 540
Query: 541 LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSAT 600
LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSAT
Sbjct: 541 LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSAT 600
Query: 601 LLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQ 660
LLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQ
Sbjct: 601 LLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQ 660
Query: 661 AAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQI 720
AAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQI
Sbjct: 661 AAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQI 720
Query: 721 PSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQ 780
PSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQ
Sbjct: 721 PSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQ 780
Query: 781 SMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREK 840
SMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREK
Sbjct: 781 SMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREK 840
Query: 841 VASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD 900
VASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD
Sbjct: 841 VASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD 900
Query: 901 RTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE 960
RTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE
Sbjct: 901 RTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE 960
Query: 961 AAHHSHQQL 969
AAHHSHQQL
Sbjct: 961 AAHHSHQQL 969
Score = 43.9 bits (102), Expect = 0.002
Identities = 51/203 (25%), Positives = 94/203 (46%), Gaps = 25/203 (12%)
Query: 1891 SQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKEL 1950
S E + + + R + + LQ+ ++ V E Q + E+L + ++L K+L
Sbjct: 756 SNAKEELELMAKKERESQMELSALQSMMA-VQEEELQVQAADMESLTRNIQIKEDLIKDL 814
Query: 1951 EHQKVERQQLLEDLREKQQEVLHFREERLSLQE-----NDSRLQHKLVLLQQQCEEKQQL 2005
+ Q V+ + + + QEVL RE+ S++ + +R Q L++L+ +E+ +L
Sbjct: 815 QMQLVDPEDI-PAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRL 873
Query: 2006 FESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSD----LSHLVAEVRALRGQLEQS 2061
E+LQ+E Q+Y SL H P SS+ L + + LR +LE+
Sbjct: 874 NEALQAERQLYS-------------SLVKFHAHPESSERDRTLQVELEGAQVLRSRLEE- 919
Query: 2062 IQGNNCLRLQLQQQLESGAGKAS 2084
+ G + RL + L + G A+
Sbjct: 920 VLGRSLERLNRLETLAAIGGAAA 942
Score = 43.1 bits (100), Expect = 0.003
Identities = 136/737 (18%), Positives = 265/737 (35%), Gaps = 104/737 (14%)
Query: 1428 YSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQARELSY 1487
Y ++ K ++ESL + + + L K + + A +++ Q+
Sbjct: 45 YKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYEL 104
Query: 1488 LRQKIR--------------------EGRGICYL-ITRHAKDTVKSFEDLLRSNDIDYYL 1526
L KI+ E C L ++ K K++ED+ D
Sbjct: 105 LENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPG----DQVK 160
Query: 1527 GQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAK 1586
+ E LAQ + E L L+ + E L +LSRE Q+ ++E +
Sbjct: 161 PDQYTEALAQRDKRIEELNQSLAAQ-----------ERLVEQLSREKQQLLHLLE----E 205
Query: 1587 LDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIH 1646
+ + P + L + T+ ++ SD S +EK ++ I
Sbjct: 206 PTSMEVQPMTEELLKQQKLNSHETTITQ---QSVSD----SHLAELQEKIQQTEATNKIL 258
Query: 1647 HSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKLASL 1706
+ + + +SQ + +L + + +E Q G + L
Sbjct: 259 QEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREML 318
Query: 1707 PQAPLPSAPSSFLPFSPTGPLLLGCCETPVVS-LAEAQQELQMLQKQLGESASTVPPAST 1765
Q+ L SS T P + S L +Q E+Q LQ+ + + + A
Sbjct: 319 HQSQLGQLHSS----EGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQ 374
Query: 1766 ATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVSGDL 1825
+S ++ H+ EL + L+ K +R + ++
Sbjct: 375 CVQFVEAAAHESEQQKEASWKHNQ-----ELRKALQQLQEELQNKSQQLRAWEAEKYNEI 429
Query: 1826 -SSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRG 1884
+ ++ LN + + L + E+ R ++++ N+ L E+L R+ A
Sbjct: 430 RTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA---- 485
Query: 1885 STSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQ 1944
++ + +E E+ + QL RE + E LR+ L S+ + +Q
Sbjct: 486 ----------VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQ 535
Query: 1945 ELEKELEHQKVERQQL------LEDLRE----------KQQEVLHFREERLSLQENDSRL 1988
+E L + +E +QL L+ L+E K+QE + ++ + SL + + +
Sbjct: 536 SMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESI-IQQLQTSLHDRNKEV 594
Query: 1989 QHKLVLL-----QQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSD 2043
+ L Q E ++L + LQ + ++ + L + K + + ++ L
Sbjct: 595 EDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEI---QGLLQS 651
Query: 2044 LSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQN-------FPA 2096
+S E +A +L Q++ N L+Q L S +P S Q
Sbjct: 652 VSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGK 711
Query: 2097 STDPGNKQLLLQDSAVS 2113
TD G+ Q+ +D + S
Sbjct: 712 QTDQGSMQIPSRDDSTS 728
Score = 33.9 bits (76), Expect = 1.9
Identities = 42/155 (27%), Positives = 65/155 (41%), Gaps = 24/155 (15%)
Query: 1926 SQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQEND 1985
++E S+ + L + LEKEL + K E + + + RE Q E+
Sbjct: 731 AKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMEL-------------- 776
Query: 1986 SRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLS 2045
S LQ + + +++ + + ESL +QI E L K L+ +D IP L+
Sbjct: 777 SALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI----KDLQMQLVDP-EDIPAMERLT 831
Query: 2046 HLVAEVRALRGQLE---QSIQGNNCLRLQLQQQLE 2077
V +R +E Q I GN R QL LE
Sbjct: 832 QEVLLLREKVASVESQGQEISGNR--RQQLLLMLE 864
Score = 32.7 bits (73), Expect = 4.3
Identities = 66/323 (20%), Positives = 128/323 (39%), Gaps = 43/323 (13%)
Query: 1843 LLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCN 1902
+L+E L E+ + +ES D + L+ L S R T Y Q +E
Sbjct: 257 ILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRER---ETEELY-QVIEGQNDTMA 312
Query: 1903 ENRVLREDNRRLQAQLSHVSREHSQETE--SLREALLSSRSHLQELEK---ELEHQKVER 1957
+ R + ++ Q S + Q+ L+ AL S+ +Q+L++ + E Q +
Sbjct: 313 KLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADA 372
Query: 1958 QQLL--------EDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESL 2009
+Q + E ++K+ H +E R +LQ+ LQ+K L+ EK +
Sbjct: 373 KQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQ 432
Query: 2010 QSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLR 2069
+ +Q H + L E+ R +++++ N L
Sbjct: 433 EQNIQHLN------------------HSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLL 474
Query: 2070 LQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFP 2129
+L+Q++ KA +I++ F A + K+ L+ ++ RD + V
Sbjct: 475 EKLRQRIHD---KAVALERAIDEKFSALEE---KEKELRQLRLAVRERDHDLERLRDVLS 528
Query: 2130 SSASSTPGSETPIINRANGLGLD 2152
S+ ++ E+ + RA GL ++
Sbjct: 529 SNEATMQSMES--LLRAKGLEVE 549
>gi|50658071 phosphodiesterase 4D interacting protein isoform 5 [Homo
sapiens]
Length = 1132
Score = 1447 bits (3747), Expect = 0.0
Identities = 761/768 (99%), Positives = 763/768 (99%)
Query: 202 LLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEK 261
L E+ + VQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEK
Sbjct: 365 LCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEK 424
Query: 262 LNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQS 321
LNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQS
Sbjct: 425 LNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQS 484
Query: 322 QLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEA 381
QLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEA
Sbjct: 485 QLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEA 544
Query: 382 AAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNH 441
AAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNH
Sbjct: 545 AAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNH 604
Query: 442 SLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEE 501
SLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEE
Sbjct: 605 SLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEE 664
Query: 502 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWL 561
KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWL
Sbjct: 665 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWL 724
Query: 562 KEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQ 621
KEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQ
Sbjct: 725 KEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQ 784
Query: 622 RKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALR 681
RKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALR
Sbjct: 785 RKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALR 844
Query: 682 QYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRST 741
QYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRST
Sbjct: 845 QYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRST 904
Query: 742 LGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLT 801
LGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLT
Sbjct: 905 LGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLT 964
Query: 802 RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL 861
RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL
Sbjct: 965 RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL 1024
Query: 862 MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVL 921
MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVL
Sbjct: 1025 MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVL 1084
Query: 922 GRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL 969
GRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL
Sbjct: 1085 GRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL 1132
Score = 78.6 bits (192), Expect = 7e-14
Identities = 132/597 (22%), Positives = 247/597 (41%), Gaps = 109/597 (18%)
Query: 31 ERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQ 90
E + E +E +K N EL+ ++ L+ ELQ+K Q L + W EAE +
Sbjct: 543 EAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL-RAW----------EAEKYNE 591
Query: 91 FEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKL------ 144
++Q +H+ L +K QLLQE L + L E N L EKL
Sbjct: 592 IRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTL-----EANEMLLEKLRQRIHD 646
Query: 145 ------KGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERL---------- 188
+ + + + + + + Q A+ +RD +E L L++ E
Sbjct: 647 KAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRA 706
Query: 189 ----VEQLSREKQQLLHLLEEPTS--MEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
VEQLS Q L L EE + Q E +++Q + + H+ + +S + L
Sbjct: 707 KGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLC 766
Query: 243 EL--------QEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRE 294
+L +E Q+ + ++LQ+ L++ + ++ + + IQ L +++ +RE
Sbjct: 767 KLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQV-------LEHEMEIQGLLQSVSTRE 819
Query: 295 RET----EELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFC 350
+E+ E+L Q + +N + LR+ LG S +P Q A + L
Sbjct: 820 QESQAAAEKLVQALMERNSELQALRQ-----YLGGRDSLMSQAPISNQQAEVTPTGCL-G 873
Query: 351 SQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQ----QKEASWKHNQELRKALQQ 406
Q + +Q R L AK+ V + + + +KE S + +E + + +
Sbjct: 874 KQTDQGSMQIPSRDDSTSLT-AKEDVSIPRSTLGDLDTVAGLEKELS--NAKEELELMAK 930
Query: 407 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKT 466
+ E Q + L++ A + E++ Q +++ L ++ KE L+++ + +Q D D
Sbjct: 931 KERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQ--MQLVDPEDIP 988
Query: 467 LEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKEL-----RQLRLAVRERDHDLE 521
+E+L Q + + EK +++E + +E+ +QL L + +
Sbjct: 989 ------AMERLTQEV--------LLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERS 1034
Query: 522 RLRDVLSSNEATMQSM-------ESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSR 571
RL + L + S+ ES R + L+VE + Q L+ +E R
Sbjct: 1035 RLNEALQAERQLYSSLVKFHAHPESSERDRTLQVE-----LEGAQVLRSRLEEVLGR 1086
Score = 43.9 bits (102), Expect = 0.002
Identities = 51/203 (25%), Positives = 94/203 (46%), Gaps = 25/203 (12%)
Query: 1891 SQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKEL 1950
S E + + + R + + LQ+ ++ V E Q + E+L + ++L K+L
Sbjct: 919 SNAKEELELMAKKERESQMELSALQSMMA-VQEEELQVQAADMESLTRNIQIKEDLIKDL 977
Query: 1951 EHQKVERQQLLEDLREKQQEVLHFREERLSLQE-----NDSRLQHKLVLLQQQCEEKQQL 2005
+ Q V+ + + + QEVL RE+ S++ + +R Q L++L+ +E+ +L
Sbjct: 978 QMQLVDPEDI-PAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRL 1036
Query: 2006 FESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSD----LSHLVAEVRALRGQLEQS 2061
E+LQ+E Q+Y SL H P SS+ L + + LR +LE+
Sbjct: 1037 NEALQAERQLYS-------------SLVKFHAHPESSERDRTLQVELEGAQVLRSRLEE- 1082
Query: 2062 IQGNNCLRLQLQQQLESGAGKAS 2084
+ G + RL + L + G A+
Sbjct: 1083 VLGRSLERLNRLETLAAIGGAAA 1105
Score = 41.6 bits (96), Expect = 0.009
Identities = 64/312 (20%), Positives = 126/312 (40%), Gaps = 46/312 (14%)
Query: 1830 SVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNF 1889
++ LN + + L + E+ R ++++ N+ L E+L R+ A
Sbjct: 598 NIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA--------- 648
Query: 1890 YSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKE 1949
++ + +E E+ + QL RE + E LR+ L S+ + +Q +E
Sbjct: 649 -----VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESL 703
Query: 1950 LEHQKVERQQL------LEDLRE----------KQQEVLHFREERLSLQENDSRLQHKLV 1993
L + +E +QL L+ L+E K+QE + ++ + SL + + ++
Sbjct: 704 LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESI-IQQLQTSLHDRNKEVEDLSA 762
Query: 1994 LL-----QQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLV 2048
L Q E ++L + LQ + ++ + L + K + + ++ L +S
Sbjct: 763 TLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEI---QGLLQSVSTRE 819
Query: 2049 AEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQN-------FPASTDPG 2101
E +A +L Q++ N L+Q L S +P S Q TD G
Sbjct: 820 QESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQG 879
Query: 2102 NKQLLLQDSAVS 2113
+ Q+ +D + S
Sbjct: 880 SMQIPSRDDSTS 891
Score = 36.6 bits (83), Expect = 0.30
Identities = 50/216 (23%), Positives = 86/216 (39%), Gaps = 36/216 (16%)
Query: 1917 QLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVER-----------QQLLEDLR 1965
Q S +H+QE LR+AL + LQ ++L + E+ Q L L
Sbjct: 551 QQKEASWKHNQE---LRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS 607
Query: 1966 EKQQEVLHFRE--------------ERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQS 2011
K+Q + FRE + L++ R+ K V L++ +EK E +
Sbjct: 608 HKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEK 667
Query: 2012 ELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQ-LEQSIQGNNCLRL 2070
EL+ + + L+ + LSS+ + + + LR + LE C L
Sbjct: 668 ELRQLRLAVRE-----RDHDLERLRDV-LSSNEATMQSMESLLRAKGLEVEQLSTTCQNL 721
Query: 2071 Q-LQQQLESGAGKASLSPSSINQNFPASTDPGNKQL 2105
Q L++++E+ + SI Q S NK++
Sbjct: 722 QWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEV 757
Score = 35.8 bits (81), Expect = 0.51
Identities = 37/155 (23%), Positives = 69/155 (44%), Gaps = 5/155 (3%)
Query: 1868 LREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQ 1927
L++Q + +T + + + ++ E I Q N++L+E + +L ++E SQ
Sbjct: 382 LKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELK-CAQESSQ 440
Query: 1928 ETE----SLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQE 1983
+ + +L+E L S +EL + +E Q +L E L + Q LH E Q+
Sbjct: 441 KQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQ 500
Query: 1984 NDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEA 2018
+ L + L Q E ++ Q E Q+ +A
Sbjct: 501 QVALLDLQSALFCSQLEIQKLQRVVRQKERQLADA 535
Score = 34.3 bits (77), Expect = 1.5
Identities = 27/113 (23%), Positives = 58/113 (51%), Gaps = 7/113 (6%)
Query: 1900 LCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQ 1959
LC + LR + + +L + +S ET ++++ S SHL EL+++++ + +
Sbjct: 365 LCEDYLPLRV--QPMTEELLKQQKLNSHETTITQQSV--SDSHLAELQEKIQQTEATNKI 420
Query: 1960 LLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSE 2012
L E L E E+ +E S Q+ D +Q+ L+ + E ++L++ ++ +
Sbjct: 421 LQEKLNEMSYELKCAQE---SSQKQDGTIQNLKETLKSRERETEELYQVIEGQ 470
Score = 33.9 bits (76), Expect = 1.9
Identities = 42/155 (27%), Positives = 65/155 (41%), Gaps = 24/155 (15%)
Query: 1926 SQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQEND 1985
++E S+ + L + LEKEL + K E + + + RE Q E+
Sbjct: 894 AKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMEL-------------- 939
Query: 1986 SRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLS 2045
S LQ + + +++ + + ESL +QI E L K L+ +D IP L+
Sbjct: 940 SALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI----KDLQMQLVDP-EDIPAMERLT 994
Query: 2046 HLVAEVRALRGQLE---QSIQGNNCLRLQLQQQLE 2077
V +R +E Q I GN R QL LE
Sbjct: 995 QEVLLLREKVASVESQGQEISGNR--RQQLLLMLE 1027
Score = 32.7 bits (73), Expect = 4.3
Identities = 66/323 (20%), Positives = 128/323 (39%), Gaps = 43/323 (13%)
Query: 1843 LLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCN 1902
+L+E L E+ + +ES D + L+ L S R T Y Q +E
Sbjct: 420 ILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRER---ETEELY-QVIEGQNDTMA 475
Query: 1903 ENRVLREDNRRLQAQLSHVSREHSQETE--SLREALLSSRSHLQELEK---ELEHQKVER 1957
+ R + ++ Q S + Q+ L+ AL S+ +Q+L++ + E Q +
Sbjct: 476 KLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADA 535
Query: 1958 QQLL--------EDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESL 2009
+Q + E ++K+ H +E R +LQ+ LQ+K L+ EK +
Sbjct: 536 KQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQ 595
Query: 2010 QSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLR 2069
+ +Q H + L E+ R +++++ N L
Sbjct: 596 EQNIQHLN------------------HSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLL 637
Query: 2070 LQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFP 2129
+L+Q++ KA +I++ F A + K+ L+ ++ RD + V
Sbjct: 638 EKLRQRIHD---KAVALERAIDEKFSALEE---KEKELRQLRLAVRERDHDLERLRDVLS 691
Query: 2130 SSASSTPGSETPIINRANGLGLD 2152
S+ ++ E+ + RA GL ++
Sbjct: 692 SNEATMQSMES--LLRAKGLEVE 712
>gi|169217962 PREDICTED: similar to phosphodiesterase 4D interacting
protein [Homo sapiens]
Length = 424
Score = 825 bits (2131), Expect = 0.0
Identities = 422/424 (99%), Positives = 422/424 (99%)
Query: 1049 MLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGK 1108
MLSLCLENAELKEQMGE MSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGK
Sbjct: 1 MLSLCLENAELKEQMGETMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGK 60
Query: 1109 LKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNV 1168
LKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNV
Sbjct: 61 LKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNV 120
Query: 1169 TVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQ 1228
TVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQ
Sbjct: 121 TVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQ 180
Query: 1229 DLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAE 1288
DLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAE
Sbjct: 181 DLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAE 240
Query: 1289 REETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKS 1348
REETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKS
Sbjct: 241 REETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKS 300
Query: 1349 ENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSS 1408
ENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERP KLRAVGTLEGSS
Sbjct: 301 ENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPRKLRAVGTLEGSS 360
Query: 1409 PHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSA 1468
PHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSA
Sbjct: 361 PHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSA 420
Query: 1469 SWPG 1472
SWPG
Sbjct: 421 SWPG 424
>gi|239752897 PREDICTED: similar to phosphodiesterase 4D interacting
protein [Homo sapiens]
Length = 259
Score = 393 bits (1009), Expect = e-108
Identities = 201/212 (94%), Positives = 203/212 (95%)
Query: 2106 LLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDTSPVMKTPPKLEG 2165
+L DSAVSPPVRDVGMNSPALV PSSASSTPGSET IINR +GLGLDTSPVMK PPKLEG
Sbjct: 13 VLDDSAVSPPVRDVGMNSPALVLPSSASSTPGSETAIINRTHGLGLDTSPVMKAPPKLEG 72
Query: 2166 DATDGSFANKHGRHVIGHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVL 2225
DATDGSFANKHGRHVIGHIDDYSALRQQI EGKLLVKKIVSLVRSACSFPGLEAQGT VL
Sbjct: 73 DATDGSFANKHGRHVIGHIDDYSALRQQIVEGKLLVKKIVSLVRSACSFPGLEAQGTGVL 132
Query: 2226 GSKGIHELRSSTSALHHALEESASLLTMFWRAALPSTHIPVLPGKVGESTERELLELRTK 2285
GSKGIHELRSSTSALHHALEESASLLTMFWR ALPSTHIPVLPGKVGESTERELLELRTK
Sbjct: 133 GSKGIHELRSSTSALHHALEESASLLTMFWRVALPSTHIPVLPGKVGESTERELLELRTK 192
Query: 2286 VSKQERLLQSTTEHLKNANQQKESMEQFIVSQ 2317
VSKQERLLQST EHLKNANQQKESMEQFIVSQ
Sbjct: 193 VSKQERLLQSTAEHLKNANQQKESMEQFIVSQ 224
>gi|169217489 PREDICTED: similar to phosphodiesterase 4D interacting
protein [Homo sapiens]
Length = 211
Score = 380 bits (975), Expect = e-104
Identities = 195/198 (98%), Positives = 197/198 (99%)
Query: 398 QELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 457
+ELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL
Sbjct: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
Query: 458 QYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 517
QYRDNSDKTLEANEMLLEKLRQRI DKAVALERAIDEKFSALEEKEKELRQLRLAVRERD
Sbjct: 62 QYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 121
Query: 518 HDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 577
HDLERLRDVLSSNEATMQ+MESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE
Sbjct: 122 HDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 181
Query: 578 SIIQQLQTSLHDRNKEVE 595
SIIQQLQTSLHDRNKEVE
Sbjct: 182 SIIQQLQTSLHDRNKEVE 199
Score = 48.5 bits (114), Expect = 8e-05
Identities = 49/224 (21%), Positives = 99/224 (44%), Gaps = 19/224 (8%)
Query: 241 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESS----QKQDGTIQNLKETLKSRERE 296
+ EL++ +QQ LQE+L S +L+ + + Q+ IQ+L +L +E+
Sbjct: 1 MEELRKALQQ-------LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQL 53
Query: 297 TEELYQVIE--GQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLE 354
+E ++++ +D + EML L +L + A+ + SAL + E
Sbjct: 54 LQEFRELLQYRDNSDKTLEANEML----LEKLRQRIRDKAVALERAIDEKFSALEEKEKE 109
Query: 355 IQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNK 414
+++L+ VR+++ L + + EA E A ++L Q LQ +
Sbjct: 110 LRQLRLAVRERDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEM 169
Query: 415 SQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 458
+ W+ E+ + I+ + ++ N + + QL R+L+Q
Sbjct: 170 ETKFSRWQKEQESIIQQLQTSLHDRNKEVEARLQL--TLRQLVQ 211
Score = 45.8 bits (107), Expect = 5e-04
Identities = 61/254 (24%), Positives = 103/254 (40%), Gaps = 52/254 (20%)
Query: 50 ELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKI 109
EL+ ++ L+ ELQ+K Q L + W EAE + ++Q +H+ L +K
Sbjct: 3 ELRKALQQLQEELQNKSQQL-RAW----------EAEKYNEIRTQEQNIQHLNHSLSHKE 51
Query: 110 QLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALA 169
QLLQE L + L E N L EKL+ + +
Sbjct: 52 QLLQEFRELLQYRDNSDKTL-----EANEMLLEKLR----------------QRIRDKAV 90
Query: 170 QRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHET 229
++ I+E +L +E+ + QL ++ H LE + L+S+E
Sbjct: 91 ALERAIDEKFSALEEKEKELRQLRLAVRERDHDLER--------------LRDVLSSNEA 136
Query: 230 TITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKET 289
T+ +S L +++Q T + LQ EM + Q ++Q+ IQ L+ +
Sbjct: 137 TM---QTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ---KEQESIIQQLQTS 190
Query: 290 LKSRERETEELYQV 303
L R +E E Q+
Sbjct: 191 LHDRNKEVEARLQL 204
Score = 36.2 bits (82), Expect = 0.39
Identities = 39/185 (21%), Positives = 80/185 (43%), Gaps = 31/185 (16%)
Query: 1830 SVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNF 1889
++ LN + + L + E+ R ++++ N+ L E+L R+ A
Sbjct: 39 NIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIRDKA--------- 89
Query: 1890 YSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKE 1949
++ + +E E+ + QL RE + E LR+ L S+ + +Q +E
Sbjct: 90 -----VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQTMESL 144
Query: 1950 LEHQKVERQQL------LEDLRE----------KQQEVLHFREERLSLQENDSRLQHKLV 1993
L + +E +QL L+ L+E K+QE + ++ + SL + + ++ +L
Sbjct: 145 LRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESI-IQQLQTSLHDRNKEVEARLQ 203
Query: 1994 LLQQQ 1998
L +Q
Sbjct: 204 LTLRQ 208
Score = 35.0 bits (79), Expect = 0.87
Identities = 43/202 (21%), Positives = 76/202 (37%), Gaps = 31/202 (15%)
Query: 1930 ESLREALLSSRSHLQELEKELEHQKVER-----------QQLLEDLREKQQEVLHFRE-- 1976
E LR+AL + LQ ++L + E+ Q L L K+Q + FRE
Sbjct: 2 EELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 61
Query: 1977 ------------ERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSK 2024
+ L++ R++ K V L++ +EK E + EL+
Sbjct: 62 QYRDNSDKTLEANEMLLEKLRQRIRDKAVALERAIDEKFSALEEKEKELRQLRLAVRE-- 119
Query: 2025 KGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQ-LQQQLESGAGKA 2083
+ + L+ + S++ + E LE C LQ L++++E+ +
Sbjct: 120 ---RDHDLERLRDVLSSNEATMQTMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRW 176
Query: 2084 SLSPSSINQNFPASTDPGNKQL 2105
SI Q S NK++
Sbjct: 177 QKEQESIIQQLQTSLHDRNKEV 198
>gi|239747450 PREDICTED: similar to phosphodiesterase 4D interacting
protein [Homo sapiens]
Length = 236
Score = 379 bits (973), Expect = e-104
Identities = 196/210 (93%), Positives = 199/210 (94%)
Query: 2108 QDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDTSPVMKTPPKLEGDA 2167
+DSAVSPPVRDVGMNS ALV PSSASST GSET IINR NGLGLDTSPVMKTPPKLEGDA
Sbjct: 5 RDSAVSPPVRDVGMNSQALVLPSSASSTSGSETAIINRTNGLGLDTSPVMKTPPKLEGDA 64
Query: 2168 TDGSFANKHGRHVIGHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGS 2227
TDGSFA+KHGRHVIGHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGS
Sbjct: 65 TDGSFASKHGRHVIGHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGS 124
Query: 2228 KGIHELRSSTSALHHALEESASLLTMFWRAALPSTHIPVLPGKVGESTERELLELRTKVS 2287
KGIHELRSSTSALHHALEESASLLTMFWRAALPSTHIP LPGKV ESTERELLELRTKVS
Sbjct: 125 KGIHELRSSTSALHHALEESASLLTMFWRAALPSTHIPALPGKVRESTERELLELRTKVS 184
Query: 2288 KQERLLQSTTEHLKNANQQKESMEQFIVSQ 2317
KQE LLQST EHLK NQQKESMEQFI+SQ
Sbjct: 185 KQEWLLQSTAEHLKIDNQQKESMEQFIISQ 214
>gi|50658077 phosphodiesterase 4D interacting protein isoform 4
[Homo sapiens]
Length = 173
Score = 343 bits (879), Expect = 1e-93
Identities = 173/173 (100%), Positives = 173/173 (100%)
Query: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR 60
MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR
Sbjct: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKR 60
Query: 61 ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK 120
ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK
Sbjct: 61 ELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAK 120
Query: 121 NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK
Sbjct: 121 NEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
Score = 42.7 bits (99), Expect = 0.004
Identities = 35/115 (30%), Positives = 52/115 (45%), Gaps = 16/115 (13%)
Query: 380 EAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL-RAW----------EAEKYNE 428
E + E +E +K N EL+ ++ L+ ELQ+K Q L + W EAE +
Sbjct: 31 ERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQ 90
Query: 429 IRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTL-----EANEMLLEKLR 478
++Q +H+ L +K QLLQE L + L E N L EKL+
Sbjct: 91 FEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLK 145
Score = 36.2 bits (82), Expect = 0.39
Identities = 29/109 (26%), Positives = 48/109 (44%), Gaps = 13/109 (11%)
Query: 1928 ETESLREALLSSRSHLQEL-----------EKELEHQKVERQQLLEDLREKQQEVLHFRE 1976
E ESL+ L + HL + E EL Q ERQQ E + E + + +
Sbjct: 54 EVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQ 113
Query: 1977 ERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKK 2025
E L +N++ LV +++C +L E L+ + +E + G+ K
Sbjct: 114 EESRLAKNEAARMAALVEAEKEC--NLELSEKLKGVTKNWEDVPGDQVK 160
>gi|50658075 phosphodiesterase 4D interacting protein isoform 3
[Homo sapiens]
Length = 310
Score = 325 bits (833), Expect = 3e-88
Identities = 164/168 (97%), Positives = 165/168 (98%)
Query: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
R +HLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK
Sbjct: 143 RDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 202
Query: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 125
KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR
Sbjct: 203 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 262
Query: 126 MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK
Sbjct: 263 MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 310
Score = 43.9 bits (102), Expect = 0.002
Identities = 41/143 (28%), Positives = 64/143 (44%), Gaps = 24/143 (16%)
Query: 360 RVVRQKERQLADAKQ-------CVQFVEAAAHES-EQQKEASWKHNQELRKALQQLQEEL 411
+ +R E+ L D K+ + F+E + E +E +K N EL+ ++ L+ EL
Sbjct: 140 QALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKREL 199
Query: 412 QNKSQQL-RAW----------EAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYR 460
Q+K Q L + W EAE + ++Q +H+ L +K QLLQE L +
Sbjct: 200 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNE 259
Query: 461 DNSDKTL-----EANEMLLEKLR 478
L E N L EKL+
Sbjct: 260 AARMAALVEAEKECNLELSEKLK 282
Score = 36.2 bits (82), Expect = 0.39
Identities = 29/109 (26%), Positives = 48/109 (44%), Gaps = 13/109 (11%)
Query: 1928 ETESLREALLSSRSHLQEL-----------EKELEHQKVERQQLLEDLREKQQEVLHFRE 1976
E ESL+ L + HL + E EL Q ERQQ E + E + + +
Sbjct: 191 EVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQ 250
Query: 1977 ERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKK 2025
E L +N++ LV +++C +L E L+ + +E + G+ K
Sbjct: 251 EESRLAKNEAARMAALVEAEKEC--NLELSEKLKGVTKNWEDVPGDQVK 297
>gi|88943074 PREDICTED: similar to Phosphodiesterase 4D interacting
protein [Homo sapiens]
Length = 134
Score = 248 bits (634), Expect = 4e-65
Identities = 125/127 (98%), Positives = 126/127 (99%)
Query: 47 RNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLE 106
+N ELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLE
Sbjct: 8 QNTELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLE 67
Query: 107 NKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTE 166
NKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTE
Sbjct: 68 NKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTE 127
Query: 167 ALAQRDK 173
ALAQRDK
Sbjct: 128 ALAQRDK 134
Score = 37.7 bits (86), Expect = 0.13
Identities = 31/98 (31%), Positives = 45/98 (45%), Gaps = 16/98 (16%)
Query: 397 NQELRKALQQLQEELQNKSQQL-RAW----------EAEKYNEIRTQEQNIQHLNHSLSH 445
N EL+ ++ L+ ELQ+K Q L + W EAE + ++Q +H+ L +
Sbjct: 9 NTELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLEN 68
Query: 446 KEQLLQEFRELLQYRDNSDKTL-----EANEMLLEKLR 478
K QLLQE L + L E N L EKL+
Sbjct: 69 KIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLK 106
Score = 36.2 bits (82), Expect = 0.39
Identities = 29/109 (26%), Positives = 48/109 (44%), Gaps = 13/109 (11%)
Query: 1928 ETESLREALLSSRSHLQEL-----------EKELEHQKVERQQLLEDLREKQQEVLHFRE 1976
E ESL+ L + HL + E EL Q ERQQ E + E + + +
Sbjct: 15 EVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQ 74
Query: 1977 ERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKK 2025
E L +N++ LV +++C +L E L+ + +E + G+ K
Sbjct: 75 EESRLAKNEAARMAALVEAEKEC--NLELSEKLKGVTKNWEDVPGDQVK 121
>gi|58535453 CDK5 regulatory subunit associated protein 2 isoform b
[Homo sapiens]
Length = 1814
Score = 226 bits (575), Expect = 3e-58
Identities = 188/641 (29%), Positives = 322/641 (50%), Gaps = 36/641 (5%)
Query: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
+ + +LKKENF+LKLRIYFLEERMQQ++ E IYK NIELKVEVESLKRELQ++
Sbjct: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
Query: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 125
+Q L K VE+L +E++R E+ +++ + V +LL +I LL+++ A+ E +
Sbjct: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
Query: 126 MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQ 185
A E EK L L KL + K E GD L ++D+ IEEL SL ++
Sbjct: 181 AFAGTETEKALRLRLESKLSEMKKMHE---GDLA----MALVLDEKDRLIEELKLSLKSK 233
Query: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245
E L++ L EK Q+ E +S E++ + ++++ + + Q +S +
Sbjct: 234 EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNS----FE 289
Query: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE 305
E+IQ L+E L E E+ +++S K+D IQ L LKS+E++ EEL IE
Sbjct: 290 ERIQ-------ALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
Query: 306 GQNDTMAKLREMLHQSQLGQLHSSEG--TSPAQQQVALLDLQSALFCSQLEIQKLQRVVR 363
+ AK RE L ++Q + SE T+ + ++ L+S E +L+R ++
Sbjct: 343 KLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIK 402
Query: 364 QKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL----R 419
+ ++L+D +Q + +E E+ ++K ++LR +++L+ E+ + + + +
Sbjct: 403 KITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462
Query: 420 AWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQ 479
+ +E ++ QEQ I+HL S + K+ LLQ+F E + L A E L +
Sbjct: 463 SLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522
Query: 480 RIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL-----ERLRDVLSSNEATM 534
I +K + + + + E+K+ + + V +++ D+ + L++ S N
Sbjct: 523 LITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582
Query: 535 QSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----LQTSLHDR 590
+ + K LE + LS QNL+ EE ++ R ++E S+ L L +
Sbjct: 583 ELNKIFALRKQLEQDVLS--YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640
Query: 591 NK-EVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDL 630
N+ +VE S L K ++ +EL Q ++ + DL
Sbjct: 641 NRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681
Score = 150 bits (379), Expect = 1e-35
Identities = 151/513 (29%), Positives = 245/513 (47%), Gaps = 104/513 (20%)
Query: 1842 DLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLC 1901
DLL EH+ EIR LR+RLEESI N++LR+QLE + + +G +++ ++ G E L
Sbjct: 1393 DLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQG---STSIFASGSELHSSLT 1449
Query: 1902 NENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLL 1961
+E LR+ N+ L A L SR+ +E + LRE+L L+ L++E K E ++L
Sbjct: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQ 1509
Query: 1962 EDLREKQQEVLHFREE-RLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALY 2020
++ EK++ +E R S QE L +Q++ + +QQL LQ
Sbjct: 1510 KEGSEKERHNQQLIQEVRCSGQE--------LSRVQEEVKLRQQLLSQNDKLLQ------ 1555
Query: 2021 GNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGA 2080
+ + LKAY L E R LR + ++ +N L Q
Sbjct: 1556 -SLRVELKAYE--------------KLDEEHRRLRDGDKYPMESDNSFDLFDSSQ----- 1595
Query: 2081 GKASLSPSSINQNFPASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSET 2140
+++P S+++ P S G ++ +L S +S+T T
Sbjct: 1596 ---AVTPKSVSETPPLS----------------------GNDTDSLSCDSGSSAT---ST 1627
Query: 2141 PIINRANGLGLDTSPVMKTPPKLEGDATDGSFANKHGRHVIGHIDDYSALRQQIAEGKLL 2200
P ++R + T L +A+K+GRHV+G I+DY AL +QI++G+ L
Sbjct: 1628 PCVSR-----------LVTGHHL--------WASKNGRHVLGLIEDYEALLKQISQGQRL 1668
Query: 2201 VKKIVSLVRSACSFPGLEAQGTEVLGSKGIH-----ELRSSTSALHHALEESASLLTMFW 2255
+ ++ + A S E LG+KG H + SS S LEE+ L + W
Sbjct: 1669 LAEMDIQTQEAPSSTSQE------LGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLW 1722
Query: 2256 RAALPST-HIPVLPGKVGESTERELLELRTKVSKQERLLQSTTEHLKNANQQKESMEQFI 2314
R +LP P+ ++GE + E+ +L K+ +QE+ LQ+T + L+ + +Q E+ I
Sbjct: 1723 RVSLPEDGQCPLHCEQIGE-MKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQ----EKVI 1777
Query: 2315 VSQLTRTHDVLKKARTNLEVKSLRALP--CTPA 2345
QL TH +L+KAR NLE++ A P C+P+
Sbjct: 1778 FDQLVVTHKILRKARGNLELRPGGAHPGTCSPS 1810
Score = 134 bits (336), Expect = 1e-30
Identities = 275/1354 (20%), Positives = 534/1354 (39%), Gaps = 188/1354 (13%)
Query: 352 QLEIQKLQRVVRQKERQLADAKQCVQ-FVEAAAHESEQQKEASWKHNQE----------- 399
++E++ L+R ++++E+ L A + V+ EA E ++ KE + K Q+
Sbjct: 107 KVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILL 166
Query: 400 LRKALQQLQEELQNK------SQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 453
L K + Q EL+ + LR K +E++ + + L K++L++E
Sbjct: 167 LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEEL 226
Query: 454 RELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAV 513
+ +L++ E L++ L++ A E + L +E ++
Sbjct: 227 K----------LSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEA 276
Query: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573
+ +H ER +S E +Q++E LR K E+ T + +++ +
Sbjct: 277 AQMEHQKER-----NSFEERIQALEEDLREKEREI----ATEKKNSLKRDKAIQGLTMAL 327
Query: 574 KEQESIIQQLQTSLHDRNKEVEDLSATL------LCKLGPGQSEIAEELCQRLQRKERML 627
K +E +++L N E+E LSA L K + + +E+ L KE +
Sbjct: 328 KSKEKKVEEL-------NSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALS 380
Query: 628 QDLLSDR-NKQVLEHEME--IQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYL 684
L S K H + I+ + Q +S +QE + + L +A E++ +R
Sbjct: 381 AALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLR 440
Query: 685 GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGD 744
+ L ++ + E L + + Q T T ++DV + + D
Sbjct: 441 NEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKD 500
Query: 745 LDTVAGLEKELSNAKEELELMAK---KERESQMELSALQSMMAVQEEELQVQAADMESLT 801
L+ + + A E+LEL ++ E+ S + +++ + +++ Q++D E L
Sbjct: 501 LEVIQ--QNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKK----QSSDYEELI 554
Query: 802 RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL 861
+ ++ ++D+ L L + + I ++ ++ LR+++ Q + +Q+
Sbjct: 555 QVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI-- 612
Query: 862 MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEV- 920
+ R + +L +++ Y S+ E + QVE + L+ ++ ++
Sbjct: 613 ---SEIRRREEESFSLYSDQTSYLSICL--------EENNRFQVEHFSQEELKKKVSDLI 661
Query: 921 -LGRSLERLNR-----LETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVAL 974
L + L N+ + L+ +G G STE T+ + A + +K+
Sbjct: 662 QLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELL----ASKEDEDTIKIGE 717
Query: 975 EKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQI 1034
+ + + Q+ S C + H E + ++ + +
Sbjct: 718 DDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHT---------ESKISDCDGAHAPGCL 768
Query: 1035 EEAGFSSV-SHIRNTMLSLCLENA--------EL---------KEQMGEAMSDGWEIEED 1076
EE F ++ + + N +L LE+ EL +E GE + DG +
Sbjct: 769 EEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHL-DGKTEKTP 827
Query: 1077 KEKGEVM--VETVVTKEGLSESSLQAEFRKLQGK------LKNAHNIINLLKEQLVLSSK 1128
K+KGE++ V+T + E L E + ++ LK+A + L+
Sbjct: 828 KQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKH 887
Query: 1129 EGNSKLTPELLVHLTSTIERINTELVGSPGKHQH--------QEEGNVTVRPFPRPQSLD 1180
E + E ++ + E L G PG E + P S
Sbjct: 888 EATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRS 947
Query: 1181 LGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEAT 1240
LG + + A Q + L L+ +L + K + L +KL+L+EA
Sbjct: 948 LGNMYRLPATQ------------EVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAV 995
Query: 1241 VFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEH 1300
+ + + +L + V + + + + + + E + ++ S E +
Sbjct: 996 MEGRPTP---DKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSE 1052
Query: 1301 NSLKEMVLMEGLCSEQGRR-------GSTLASSSERKPLENQLGKQEEFRVYGKSENILV 1353
+ + C E + L+S S+ + +G + + +E
Sbjct: 1053 ICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEY- 1111
Query: 1354 LRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEG-SSPHSV 1412
L++ I DL+ +L+ I L+ + E G +G S P +
Sbjct: 1112 LKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTE--------GAQDGLSKPKNG 1163
Query: 1413 PDEDEGWLSDGTGAFY----------SPGLQAKKDLESLIQRVSQLEAQLPKN-GLEEKL 1461
D +E S Y +P + + LE+L Q++ + E +L K L +L
Sbjct: 1164 SDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQL 1223
Query: 1462 AEELRSAS------WPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFED 1515
E+ + P +YDSL+Q QARELS RQ+I++G GIC + +H +K+FE+
Sbjct: 1224 FSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEE 1283
Query: 1516 LLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQE 1575
LL+++D+DY + + F+EQL Q ++L E+L KL G+E + EL E
Sbjct: 1284 LLQASDVDYCVAEGFQEQLNQCAELLEKL-EKLFLNG-----KSVGVE---MNTQNELME 1334
Query: 1576 KEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSS 1609
+ + + L S PS+SHALSD S S
Sbjct: 1335 RIEEDNLTYQHLLPESPEPSASHALSDYETSEKS 1368
Score = 72.4 bits (176), Expect = 5e-12
Identities = 143/676 (21%), Positives = 283/676 (41%), Gaps = 119/676 (17%)
Query: 186 ERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
E + +L +E L ++ LEE E TE + K T I + +S
Sbjct: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYK--------TNIELKVEVESLKR 115
Query: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNL--------KETLKSRE 294
ELQE+ Q +K ++ E++ +E ++K+ +++L ++ + + +
Sbjct: 116 ELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175
Query: 295 RETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPA---QQQVALLDLQSALFCS 351
E E+ + E + +L L S++ ++H + ++ + +L+ +L
Sbjct: 176 AELEKAFAGTETEKALRLRLESKL--SEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSK 233
Query: 352 QLEIQKLQRVVRQKERQLADAKQCVQFVE------AAAHESEQQKEASWKHNQELRKA-- 403
+ IQ L ++++ Q+A + V E A E E++ EA+ +Q+ R +
Sbjct: 234 EALIQCL----KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFE 289
Query: 404 --LQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD 461
+Q L+E+L+ K +++ EK N ++ +++ IQ L +L KE+ ++E
Sbjct: 290 ERIQALEEDLREKEREIAT---EKKNSLK-RDKAIQGLTMALKSKEKKVEEL-------- 337
Query: 462 NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLE 521
NS+ +EKL AL++A ++F E+ E L E
Sbjct: 338 NSE---------IEKLSAAFAKAREALQKAQTQEFQGSEDYETALS-----------GKE 377
Query: 522 RLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQ 581
L L S T + LR +++++ +LQ +E +E +E+
Sbjct: 378 ALSAALRSQNLTKSTENHRLRRS---IKKITQELSDLQQERERLEKDLEEAHREKS---- 430
Query: 582 QLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEH 641
+ ++ D EVE L E+ +R + E + LLS+ NK++
Sbjct: 431 KGDCTIRDLRNEVEKLR---------------NEVNEREKAMENRYKSLLSESNKKLHNQ 475
Query: 642 EMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQA 701
E I+ L +S + ++ Q EK ++ ++++N L A + L+++ S+QQ
Sbjct: 476 EQVIKHLTESTNQKDVLLQKFNEKDLE-VIQQNCYLMAAEDLELRSEGLITE-KCSSQQP 533
Query: 702 EVTPTGCLGKQTDQGS-----MQI--PSRDDSTSL--TAKEDVSIPRSTLGDLDTVAGLE 752
+ T K+ Q S +Q+ +D T L + +E SI + +L+ + L
Sbjct: 534 PGSKT-IFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSI-NNLQAELNKIFALR 591
Query: 753 KEL-----------SNAKEELELMAKKERESQMELSALQSMMAVQEEE---LQVQAADME 798
K+L +E++ + ++E ES S S +++ EE QV+ E
Sbjct: 592 KQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQE 651
Query: 799 SLTRNIQIKEDLIKDL 814
L + + L+K+L
Sbjct: 652 ELKKKVSDLIQLVKEL 667
Score = 47.8 bits (112), Expect = 1e-04
Identities = 82/412 (19%), Positives = 161/412 (39%), Gaps = 63/412 (15%)
Query: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRR-QFEERQQETEHVYELLENKIQLLQ 113
+E+LK++L++++ L K +NLN Q +E+ Q + R L++++ + L
Sbjct: 1199 LENLKQQLEEQEYKLQKE----QNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELS 1254
Query: 114 EESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
+ + K+ + E L+ ++ G Q + +Q E L + +K
Sbjct: 1255 LQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEK 1314
Query: 174 RI---EELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETT 230
+ + + Q L+E++ + HLL P + E L+ +ET+
Sbjct: 1315 LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLL---------PESPEPSASHALSDYETS 1365
Query: 231 ITQQSVSDSHLAELQEKIQQTEAT----NKILQEKLNEMSYELKCAQESSQKQDGTIQNL 286
S + Q++ +TE T N Q+ L E E++ ++ ++ T + L
Sbjct: 1366 ------EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKL 1419
Query: 287 KETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQS 346
++ L ER+ E ++G A E LH S ++H + A L +
Sbjct: 1420 RKQL---ERQGSEF---VQGSTSIFASGSE-LHSSLTSEIHFLRKQNQA--------LNA 1464
Query: 347 ALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQ 406
L + QK +R ES +K S +H Q ++++
Sbjct: 1465 MLIKGSRDKQKENDKLR---------------------ESLSRKTVSLEHLQREYASVKE 1503
Query: 407 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 458
E LQ + + + E+R Q + + + ++QLL + +LLQ
Sbjct: 1504 ENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ 1555
Score = 45.4 bits (106), Expect = 6e-04
Identities = 61/236 (25%), Positives = 103/236 (43%), Gaps = 37/236 (15%)
Query: 1876 LTSTARGRGSTSNFYSQGLE-SIPQLCNENRVLREDNRRLQAQLSHVSREHSQ------- 1927
L++ R + T + + L SI ++ E L+++ RL+ L RE S+
Sbjct: 379 LSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRD 438
Query: 1928 ---ETESLR------EALLSSR--SHLQELEKELEHQKVERQQLLEDLREKQQEVLHFRE 1976
E E LR E + +R S L E K+L +Q+ + L E +K + F E
Sbjct: 439 LRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNE 498
Query: 1977 ERLS-LQEN-------DSRLQHKLVLLQQQCEEKQQ-----LFESLQSELQIYEALYGNS 2023
+ L +Q+N D L+ + L+ ++C +Q +F + + YE L
Sbjct: 499 KDLEVIQQNCYLMAAEDLELRSE-GLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVL 557
Query: 2024 KKGLKAYSLDACHQIPLSSDLSHLVAEVR---ALRGQLEQSIQGNNCLRLQLQQQL 2076
KK Y+ + S +++L AE+ ALR QLEQ + LR L++Q+
Sbjct: 558 KKEQDIYT-HLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI 612
Score = 40.4 bits (93), Expect = 0.021
Identities = 83/397 (20%), Positives = 166/397 (41%), Gaps = 56/397 (14%)
Query: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
RTL + L + K N L+ ++ ER ++ I+ EL + S L+ +
Sbjct: 1403 RTLRKRLEESIKTNEKLRKQL----ERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQ 1458
Query: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENK---IQLLQEESRLAKNE 122
Q L+ A L + ++Q+E + + E L K ++ LQ E K E
Sbjct: 1459 NQALN--------------AMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEE 1504
Query: 123 AARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSL 182
R+ ++ N +L ++++ + V ++VK Q + L+Q DK ++ L L
Sbjct: 1505 NERLQKEGSEKERHNQQLIQEVRCSGQELSRVQ-EEVKLRQ--QLLSQNDKLLQSLRVEL 1561
Query: 183 AAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
A E+L E+ R + + +E S ++ ++ + + + ET + +DS
Sbjct: 1562 KAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPK---SVSETPPLSGNDTDSLSC 1618
Query: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQN----LKETLKSRERETE 298
+ T ++++ + L A ++ + G I++ LK+ + + E
Sbjct: 1619 DSGSSATSTPCVSRLV------TGHHL-WASKNGRHVLGLIEDYEALLKQISQGQRLLAE 1671
Query: 299 ELYQVIEGQNDTMAKL-REMLHQSQLGQLHSSEGTS-----PAQQQVALL-------DLQ 345
Q E + T +L + H + L + SS T+ A +++ LL D Q
Sbjct: 1672 MDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQ 1731
Query: 346 SALFCSQL-----EIQKLQRVVRQKERQLADAKQCVQ 377
L C Q+ E+ KL + + ++E++L + + +Q
Sbjct: 1732 CPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQ 1768
Score = 36.2 bits (82), Expect = 0.39
Identities = 98/448 (21%), Positives = 178/448 (39%), Gaps = 89/448 (19%)
Query: 411 LQNKSQQLRAWEAEKYNEIRTQEQNIQHLN--HSLSHKEQLLQEFRELLQYRDNSDKTLE 468
L+N QQL E ++Y + Q N+Q + H+L +K FR+L R +S +
Sbjct: 1199 LENLKQQL---EEQEYKLQKEQNLNMQLFSEIHNLQNK------FRDLSPPRYDSLVQSQ 1249
Query: 469 ANEMLLEKL------------RQRIHDKAVALE---RAIDEKFSALEEKEKELRQLRLAV 513
A E+ L++ RQ ++ A E +A D + E +++L Q +
Sbjct: 1250 ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELL 1309
Query: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573
+ LE+L S M + L+ +E+ + T Q+L L E E S
Sbjct: 1310 EK----LEKLFLNGKSVGVEMNTQNELME----RIEEDNLTYQHL--LPESPEPSASHAL 1359
Query: 574 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 633
+ E+ + + ++ E E S + QDLL
Sbjct: 1360 SDYETSEKSFFSRDQKQDNETEKTSVMV----------------------NSFSQDLL-- 1395
Query: 634 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 693
+EH EI+ L + R +ES EKL + L + SE ++ G S+ +
Sbjct: 1396 -----MEHIQEIRTLRK----RLEESIKTNEKLRKQLERQGSE------FVQGSTSIFAS 1440
Query: 694 APISNQQAEVTPTGCLGKQTDQG--SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL 751
S + +T ++ +Q +M I D K S+ R T+ ++ L
Sbjct: 1441 G--SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV----SLEHL 1494
Query: 752 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 811
++E ++ KEE E + K+ E + L + +EL +++ + + + L+
Sbjct: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLL 1554
Query: 812 KDLQMQLVDPEDIPAMERLTQEVLLLRE 839
+ L+++L A E+L +E LR+
Sbjct: 1555 QSLRVEL------KAYEKLDEEHRRLRD 1576
Score = 35.4 bits (80), Expect = 0.66
Identities = 36/133 (27%), Positives = 61/133 (45%), Gaps = 14/133 (10%)
Query: 1949 ELEHQKVER------QQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEK 2002
++EHQK Q L EDLREK++E+ E+ + + D +Q L + K
Sbjct: 278 QMEHQKERNSFEERIQALEEDLREKEREI---ATEKKNSLKRDKAIQG----LTMALKSK 330
Query: 2003 QQLFESLQSELQIYEALYGNSKKGL-KAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQS 2061
++ E L SE++ A + +++ L KA + + + LS A ALR Q
Sbjct: 331 EKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTK 390
Query: 2062 IQGNNCLRLQLQQ 2074
N+ LR +++
Sbjct: 391 STENHRLRRSIKK 403
Score = 34.7 bits (78), Expect = 1.1
Identities = 60/282 (21%), Positives = 117/282 (41%), Gaps = 35/282 (12%)
Query: 1848 LGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVL 1907
L E L + L+ S+ + L + L+ + A + S+ +GL + P
Sbjct: 216 LDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAP--------- 266
Query: 1908 REDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQK---VERQQLLEDL 1964
RE+ R + EH +E S E + + L+E E+E+ +K ++R + ++ L
Sbjct: 267 REEKER---ETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGL 323
Query: 1965 ------REKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEA 2018
+EK+ E L+ E+LS +R LQ+ ++ Q E ++ L EA
Sbjct: 324 TMALKSKEKKVEELNSEIEKLSAAFAKAR-----EALQKAQTQEFQGSEDYETALSGKEA 378
Query: 2019 LYG-----NSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQ---GNNCLRL 2070
L N K + + L + ++ +LS L E L LE++ + +C
Sbjct: 379 LSAALRSQNLTKSTENHRLRRSIK-KITQELSDLQQERERLEKDLEEAHREKSKGDCTIR 437
Query: 2071 QLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAV 2112
L+ ++E + + ++ + + NK+L Q+ +
Sbjct: 438 DLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI 479
Score = 34.7 bits (78), Expect = 1.1
Identities = 50/249 (20%), Positives = 102/249 (40%), Gaps = 38/249 (15%)
Query: 63 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNE 122
+D+KQ + V +NS ++ L +E + + + E ++ +L ++ R
Sbjct: 1372 RDQKQDNETEKTSVM-VNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEF 1430
Query: 123 AARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSL 182
++ + E + L+ ++ + K + + +K RDK+ E
Sbjct: 1431 VQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIK--------GSRDKQKEN----- 1477
Query: 183 AAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
++L E LSR+ L HL E S++ EE + QK S + QQ + + +
Sbjct: 1478 ---DKLRESLSRKTVSLEHLQREYASVK-----EENERLQKEGSEKERHNQQLIQEVRCS 1529
Query: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQ 302
++L+ + E+K Q+ + D +Q+L+ LK+ E+ EE +
Sbjct: 1530 ----------------GQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRR 1573
Query: 303 VIEGQNDTM 311
+ +G M
Sbjct: 1574 LRDGDKYPM 1582
Score = 33.5 bits (75), Expect = 2.5
Identities = 37/149 (24%), Positives = 69/149 (46%), Gaps = 16/149 (10%)
Query: 1844 LEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNE 1903
L+ L +I LR++LE+ + LR+ LE +++ R + + YS S +C
Sbjct: 580 LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSD-QTSYLSIC-- 636
Query: 1904 NRVLREDNRRLQAQLSHVSREHSQETES----LREALLSSRSHLQELEKELEHQKVERQQ 1959
L E+NR Q+ H S+E ++ S L + L + HL++ +L +
Sbjct: 637 ---LEENNR---FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNG 690
Query: 1960 LLEDLREKQQ-EVLHFREER--LSLQEND 1985
+ L +Q E+L +E+ + + E+D
Sbjct: 691 FPDRLASTEQTELLASKEDEDTIKIGEDD 719
>gi|58535451 CDK5 regulatory subunit associated protein 2 isoform a
[Homo sapiens]
Length = 1893
Score = 226 bits (575), Expect = 3e-58
Identities = 188/641 (29%), Positives = 322/641 (50%), Gaps = 36/641 (5%)
Query: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
+ + +LKKENF+LKLRIYFLEERMQQ++ E IYK NIELKVEVESLKRELQ++
Sbjct: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
Query: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 125
+Q L K VE+L +E++R E+ +++ + V +LL +I LL+++ A+ E +
Sbjct: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
Query: 126 MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQ 185
A E EK L L KL + K E GD L ++D+ IEEL SL ++
Sbjct: 181 AFAGTETEKALRLRLESKLSEMKKMHE---GDLA----MALVLDEKDRLIEELKLSLKSK 233
Query: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245
E L++ L EK Q+ E +S E++ + ++++ + + Q +S +
Sbjct: 234 EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNS----FE 289
Query: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE 305
E+IQ L+E L E E+ +++S K+D IQ L LKS+E++ EEL IE
Sbjct: 290 ERIQ-------ALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
Query: 306 GQNDTMAKLREMLHQSQLGQLHSSEG--TSPAQQQVALLDLQSALFCSQLEIQKLQRVVR 363
+ AK RE L ++Q + SE T+ + ++ L+S E +L+R ++
Sbjct: 343 KLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIK 402
Query: 364 QKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL----R 419
+ ++L+D +Q + +E E+ ++K ++LR +++L+ E+ + + + +
Sbjct: 403 KITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462
Query: 420 AWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQ 479
+ +E ++ QEQ I+HL S + K+ LLQ+F E + L A E L +
Sbjct: 463 SLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522
Query: 480 RIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL-----ERLRDVLSSNEATM 534
I +K + + + + E+K+ + + V +++ D+ + L++ S N
Sbjct: 523 LITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582
Query: 535 QSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----LQTSLHDR 590
+ + K LE + LS QNL+ EE ++ R ++E S+ L L +
Sbjct: 583 ELNKIFALRKQLEQDVLS--YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640
Query: 591 NK-EVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDL 630
N+ +VE S L K ++ +EL Q ++ + DL
Sbjct: 641 NRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681
Score = 204 bits (518), Expect = 1e-51
Identities = 170/523 (32%), Positives = 277/523 (52%), Gaps = 45/523 (8%)
Query: 1842 DLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLC 1901
DLL EH+ EIR LR+RLEESI N++LR+QLE + + +G +++ ++ G E L
Sbjct: 1393 DLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQG---STSIFASGSELHSSLT 1449
Query: 1902 NENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLL 1961
+E LR+ N+ L A L SR+ +E + LRE+L L+ L++E K E ++L
Sbjct: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQ 1509
Query: 1962 EDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYG 2021
++ EK++ +E + SR+Q ++ L QQ + +L +SL+ EL+ YE L
Sbjct: 1510 KEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDE 1569
Query: 2022 NSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAG 2081
++ +A Q P DL L+ E++ALR QLE+SI+ ++ L+ +L++QL GA
Sbjct: 1570 EHRRLREASGEGWKGQDPF-RDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQLARGAE 1628
Query: 2082 KA-----SLSPSSIN-QNFPASTD--PGNKQLLLQDSAVSPPVRDVGMNSPALVFPSSAS 2133
KA +L+ +++ P D G+K + D++ +S V P S S
Sbjct: 1629 KAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDL------FDSSQAVTPKSVS 1682
Query: 2134 STP---GSETPIINRANGLGLDTSPVMKTPPKLEGDATDGSFANKHGRHVIGHIDDYSAL 2190
TP G++T ++ +G S TP +A+K+GRHV+G I+DY AL
Sbjct: 1683 ETPPLSGNDTDSLSCDSG-----SSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEAL 1737
Query: 2191 RQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIH-----ELRSSTSALHHALE 2245
+QI++G+ L+ ++ + A S E LG+KG H + SS S LE
Sbjct: 1738 LKQISQGQRLLAEMDIQTQEAPSSTSQE------LGTKGPHPAPLSKFVSSVSTAKLTLE 1791
Query: 2246 ESASLLTMFWRAALPST-HIPVLPGKVGESTERELLELRTKVSKQERLLQSTTEHLKNAN 2304
E+ L + WR +LP P+ ++GE + E+ +L K+ +QE+ LQ+T + L+ +
Sbjct: 1792 EAYRRLKLLWRVSLPEDGQCPLHCEQIGE-MKAEVTKLHKKLFEQEKKLQNTMKLLQLSK 1850
Query: 2305 QQKESMEQFIVSQLTRTHDVLKKARTNLEVKSLRALP--CTPA 2345
+Q E+ I QL TH +L+KAR NLE++ A P C+P+
Sbjct: 1851 RQ----EKVIFDQLVVTHKILRKARGNLELRPGGAHPGTCSPS 1889
Score = 134 bits (336), Expect = 1e-30
Identities = 275/1354 (20%), Positives = 534/1354 (39%), Gaps = 188/1354 (13%)
Query: 352 QLEIQKLQRVVRQKERQLADAKQCVQ-FVEAAAHESEQQKEASWKHNQE----------- 399
++E++ L+R ++++E+ L A + V+ EA E ++ KE + K Q+
Sbjct: 107 KVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILL 166
Query: 400 LRKALQQLQEELQNK------SQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 453
L K + Q EL+ + LR K +E++ + + L K++L++E
Sbjct: 167 LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEEL 226
Query: 454 RELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAV 513
+ +L++ E L++ L++ A E + L +E ++
Sbjct: 227 K----------LSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEA 276
Query: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573
+ +H ER +S E +Q++E LR K E+ T + +++ +
Sbjct: 277 AQMEHQKER-----NSFEERIQALEEDLREKEREI----ATEKKNSLKRDKAIQGLTMAL 327
Query: 574 KEQESIIQQLQTSLHDRNKEVEDLSATL------LCKLGPGQSEIAEELCQRLQRKERML 627
K +E +++L N E+E LSA L K + + +E+ L KE +
Sbjct: 328 KSKEKKVEEL-------NSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALS 380
Query: 628 QDLLSDR-NKQVLEHEME--IQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYL 684
L S K H + I+ + Q +S +QE + + L +A E++ +R
Sbjct: 381 AALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLR 440
Query: 685 GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGD 744
+ L ++ + E L + + Q T T ++DV + + D
Sbjct: 441 NEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKD 500
Query: 745 LDTVAGLEKELSNAKEELELMAK---KERESQMELSALQSMMAVQEEELQVQAADMESLT 801
L+ + + A E+LEL ++ E+ S + +++ + +++ Q++D E L
Sbjct: 501 LEVIQ--QNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKK----QSSDYEELI 554
Query: 802 RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL 861
+ ++ ++D+ L L + + I ++ ++ LR+++ Q + +Q+
Sbjct: 555 QVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI-- 612
Query: 862 MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEV- 920
+ R + +L +++ Y S+ E + QVE + L+ ++ ++
Sbjct: 613 ---SEIRRREEESFSLYSDQTSYLSICL--------EENNRFQVEHFSQEELKKKVSDLI 661
Query: 921 -LGRSLERLNR-----LETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVAL 974
L + L N+ + L+ +G G STE T+ + A + +K+
Sbjct: 662 QLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELL----ASKEDEDTIKIGE 717
Query: 975 EKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQI 1034
+ + + Q+ S C + H E + ++ + +
Sbjct: 718 DDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHT---------ESKISDCDGAHAPGCL 768
Query: 1035 EEAGFSSV-SHIRNTMLSLCLENA--------EL---------KEQMGEAMSDGWEIEED 1076
EE F ++ + + N +L LE+ EL +E GE + DG +
Sbjct: 769 EEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHL-DGKTEKTP 827
Query: 1077 KEKGEVM--VETVVTKEGLSESSLQAEFRKLQGK------LKNAHNIINLLKEQLVLSSK 1128
K+KGE++ V+T + E L E + ++ LK+A + L+
Sbjct: 828 KQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKH 887
Query: 1129 EGNSKLTPELLVHLTSTIERINTELVGSPGKHQH--------QEEGNVTVRPFPRPQSLD 1180
E + E ++ + E L G PG E + P S
Sbjct: 888 EATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRS 947
Query: 1181 LGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEAT 1240
LG + + A Q + L L+ +L + K + L +KL+L+EA
Sbjct: 948 LGNMYRLPATQ------------EVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAV 995
Query: 1241 VFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEH 1300
+ + + +L + V + + + + + + E + ++ S E +
Sbjct: 996 MEGRPTP---DKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSE 1052
Query: 1301 NSLKEMVLMEGLCSEQGRR-------GSTLASSSERKPLENQLGKQEEFRVYGKSENILV 1353
+ + C E + L+S S+ + +G + + +E
Sbjct: 1053 ICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEY- 1111
Query: 1354 LRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEG-SSPHSV 1412
L++ I DL+ +L+ I L+ + E G +G S P +
Sbjct: 1112 LKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTE--------GAQDGLSKPKNG 1163
Query: 1413 PDEDEGWLSDGTGAFY----------SPGLQAKKDLESLIQRVSQLEAQLPKN-GLEEKL 1461
D +E S Y +P + + LE+L Q++ + E +L K L +L
Sbjct: 1164 SDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQL 1223
Query: 1462 AEELRSAS------WPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFED 1515
E+ + P +YDSL+Q QARELS RQ+I++G GIC + +H +K+FE+
Sbjct: 1224 FSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEE 1283
Query: 1516 LLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQE 1575
LL+++D+DY + + F+EQL Q ++L E+L KL G+E + EL E
Sbjct: 1284 LLQASDVDYCVAEGFQEQLNQCAELLEKL-EKLFLNG-----KSVGVE---MNTQNELME 1334
Query: 1576 KEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSS 1609
+ + + L S PS+SHALSD S S
Sbjct: 1335 RIEEDNLTYQHLLPESPEPSASHALSDYETSEKS 1368
Score = 72.4 bits (176), Expect = 5e-12
Identities = 143/676 (21%), Positives = 283/676 (41%), Gaps = 119/676 (17%)
Query: 186 ERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
E + +L +E L ++ LEE E TE + K T I + +S
Sbjct: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYK--------TNIELKVEVESLKR 115
Query: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNL--------KETLKSRE 294
ELQE+ Q +K ++ E++ +E ++K+ +++L ++ + + +
Sbjct: 116 ELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175
Query: 295 RETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPA---QQQVALLDLQSALFCS 351
E E+ + E + +L L S++ ++H + ++ + +L+ +L
Sbjct: 176 AELEKAFAGTETEKALRLRLESKL--SEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSK 233
Query: 352 QLEIQKLQRVVRQKERQLADAKQCVQFVE------AAAHESEQQKEASWKHNQELRKA-- 403
+ IQ L ++++ Q+A + V E A E E++ EA+ +Q+ R +
Sbjct: 234 EALIQCL----KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFE 289
Query: 404 --LQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD 461
+Q L+E+L+ K +++ EK N ++ +++ IQ L +L KE+ ++E
Sbjct: 290 ERIQALEEDLREKEREIAT---EKKNSLK-RDKAIQGLTMALKSKEKKVEEL-------- 337
Query: 462 NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLE 521
NS+ +EKL AL++A ++F E+ E L E
Sbjct: 338 NSE---------IEKLSAAFAKAREALQKAQTQEFQGSEDYETALS-----------GKE 377
Query: 522 RLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQ 581
L L S T + LR +++++ +LQ +E +E +E+
Sbjct: 378 ALSAALRSQNLTKSTENHRLRRS---IKKITQELSDLQQERERLEKDLEEAHREKS---- 430
Query: 582 QLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEH 641
+ ++ D EVE L E+ +R + E + LLS+ NK++
Sbjct: 431 KGDCTIRDLRNEVEKLR---------------NEVNEREKAMENRYKSLLSESNKKLHNQ 475
Query: 642 EMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQA 701
E I+ L +S + ++ Q EK ++ ++++N L A + L+++ S+QQ
Sbjct: 476 EQVIKHLTESTNQKDVLLQKFNEKDLE-VIQQNCYLMAAEDLELRSEGLITE-KCSSQQP 533
Query: 702 EVTPTGCLGKQTDQGS-----MQI--PSRDDSTSL--TAKEDVSIPRSTLGDLDTVAGLE 752
+ T K+ Q S +Q+ +D T L + +E SI + +L+ + L
Sbjct: 534 PGSKT-IFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSI-NNLQAELNKIFALR 591
Query: 753 KEL-----------SNAKEELELMAKKERESQMELSALQSMMAVQEEE---LQVQAADME 798
K+L +E++ + ++E ES S S +++ EE QV+ E
Sbjct: 592 KQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQE 651
Query: 799 SLTRNIQIKEDLIKDL 814
L + + L+K+L
Sbjct: 652 ELKKKVSDLIQLVKEL 667
Score = 50.1 bits (118), Expect = 3e-05
Identities = 104/504 (20%), Positives = 198/504 (39%), Gaps = 79/504 (15%)
Query: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRR-QFEERQQETEHVYELLENKIQLLQ 113
+E+LK++L++++ L K +NLN Q +E+ Q + R L++++ + L
Sbjct: 1199 LENLKQQLEEQEYKLQKE----QNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELS 1254
Query: 114 EESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
+ + K+ + E L+ ++ G Q + +Q E L + +K
Sbjct: 1255 LQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEK 1314
Query: 174 RI---EELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETT 230
+ + + Q L+E++ + HLL P + E L+ +ET+
Sbjct: 1315 LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLL---------PESPEPSASHALSDYETS 1365
Query: 231 ITQQSVSDSHLAELQEKIQQTEAT----NKILQEKLNEMSYELKCAQESSQKQDGTIQNL 286
S + Q++ +TE T N Q+ L E E++ ++ ++ T + L
Sbjct: 1366 ------EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKL 1419
Query: 287 KETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQS 346
++ L ER+ E ++G A E LH S ++H + A L +
Sbjct: 1420 RKQL---ERQGSEF---VQGSTSIFASGSE-LHSSLTSEIHFLRKQNQA--------LNA 1464
Query: 347 ALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQ 406
L + QK +R ES +K S +H Q ++++
Sbjct: 1465 MLIKGSRDKQKENDKLR---------------------ESLSRKTVSLEHLQREYASVKE 1503
Query: 407 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKT 466
E LQ + + + E+R Q + + + ++QLL + +LLQ +
Sbjct: 1504 ENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ---SLRVE 1560
Query: 467 LEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDV 526
L+A E L E+ R+ L A E + ++ ++L L + ++ LER +
Sbjct: 1561 LKAYEKLDEEHRR--------LREASGEGWKG-QDPFRDLHSLLMEIQALRLQLERSIET 1611
Query: 527 LSSNEATMQSMESLLRAKGLEVEQ 550
S T+QS A+G E Q
Sbjct: 1612 SS----TLQSRLKEQLARGAEKAQ 1631
Score = 45.4 bits (106), Expect = 6e-04
Identities = 61/236 (25%), Positives = 103/236 (43%), Gaps = 37/236 (15%)
Query: 1876 LTSTARGRGSTSNFYSQGLE-SIPQLCNENRVLREDNRRLQAQLSHVSREHSQ------- 1927
L++ R + T + + L SI ++ E L+++ RL+ L RE S+
Sbjct: 379 LSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRD 438
Query: 1928 ---ETESLR------EALLSSR--SHLQELEKELEHQKVERQQLLEDLREKQQEVLHFRE 1976
E E LR E + +R S L E K+L +Q+ + L E +K + F E
Sbjct: 439 LRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNE 498
Query: 1977 ERLS-LQEN-------DSRLQHKLVLLQQQCEEKQQ-----LFESLQSELQIYEALYGNS 2023
+ L +Q+N D L+ + L+ ++C +Q +F + + YE L
Sbjct: 499 KDLEVIQQNCYLMAAEDLELRSE-GLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVL 557
Query: 2024 KKGLKAYSLDACHQIPLSSDLSHLVAEVR---ALRGQLEQSIQGNNCLRLQLQQQL 2076
KK Y+ + S +++L AE+ ALR QLEQ + LR L++Q+
Sbjct: 558 KKEQDIYT-HLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI 612
Score = 40.4 bits (93), Expect = 0.021
Identities = 112/521 (21%), Positives = 206/521 (39%), Gaps = 94/521 (18%)
Query: 411 LQNKSQQLRAWEAEKYNEIRTQEQNIQHLN--HSLSHKEQLLQEFRELLQYRDNSDKTLE 468
L+N QQL E ++Y + Q N+Q + H+L +K FR+L R +S +
Sbjct: 1199 LENLKQQL---EEQEYKLQKEQNLNMQLFSEIHNLQNK------FRDLSPPRYDSLVQSQ 1249
Query: 469 ANEMLLEKL------------RQRIHDKAVALE---RAIDEKFSALEEKEKELRQLRLAV 513
A E+ L++ RQ ++ A E +A D + E +++L Q +
Sbjct: 1250 ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELL 1309
Query: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573
+ LE+L S M + L+ +E+ + T Q+L L E E S
Sbjct: 1310 EK----LEKLFLNGKSVGVEMNTQNELME----RIEEDNLTYQHL--LPESPEPSASHAL 1359
Query: 574 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 633
+ E+ + + ++ E E S + QDLL
Sbjct: 1360 SDYETSEKSFFSRDQKQDNETEKTSVMV----------------------NSFSQDLL-- 1395
Query: 634 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 693
+EH EI+ L + R +ES EKL + L + SE ++ G S+ +
Sbjct: 1396 -----MEHIQEIRTLRK----RLEESIKTNEKLRKQLERQGSE------FVQGSTSIFAS 1440
Query: 694 APISNQQAEVTPTGCLGKQTDQG--SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL 751
S + +T ++ +Q +M I D K S+ R T+ ++ L
Sbjct: 1441 G--SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV----SLEHL 1494
Query: 752 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 811
++E ++ KEE E + K+ E + L + +EL +++ + + + L+
Sbjct: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLL 1554
Query: 812 KDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERS 871
+ L+++L A E+L +E LRE AS E + LL+ ++ L R
Sbjct: 1555 QSLRVEL------KAYEKLDEEHRRLRE--ASGEGWKGQDPFRDLHSLLMEIQAL---RL 1603
Query: 872 RLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQV 912
+L +++ L S L + A ++ L + ++ +
Sbjct: 1604 QLERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSI 1644
Score = 35.4 bits (80), Expect = 0.66
Identities = 36/133 (27%), Positives = 61/133 (45%), Gaps = 14/133 (10%)
Query: 1949 ELEHQKVER------QQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEK 2002
++EHQK Q L EDLREK++E+ E+ + + D +Q L + K
Sbjct: 278 QMEHQKERNSFEERIQALEEDLREKEREI---ATEKKNSLKRDKAIQG----LTMALKSK 330
Query: 2003 QQLFESLQSELQIYEALYGNSKKGL-KAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQS 2061
++ E L SE++ A + +++ L KA + + + LS A ALR Q
Sbjct: 331 EKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTK 390
Query: 2062 IQGNNCLRLQLQQ 2074
N+ LR +++
Sbjct: 391 STENHRLRRSIKK 403
Score = 34.7 bits (78), Expect = 1.1
Identities = 60/282 (21%), Positives = 117/282 (41%), Gaps = 35/282 (12%)
Query: 1848 LGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVL 1907
L E L + L+ S+ + L + L+ + A + S+ +GL + P
Sbjct: 216 LDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAP--------- 266
Query: 1908 REDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQK---VERQQLLEDL 1964
RE+ R + EH +E S E + + L+E E+E+ +K ++R + ++ L
Sbjct: 267 REEKER---ETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGL 323
Query: 1965 ------REKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEA 2018
+EK+ E L+ E+LS +R LQ+ ++ Q E ++ L EA
Sbjct: 324 TMALKSKEKKVEELNSEIEKLSAAFAKAR-----EALQKAQTQEFQGSEDYETALSGKEA 378
Query: 2019 LYG-----NSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQ---GNNCLRL 2070
L N K + + L + ++ +LS L E L LE++ + +C
Sbjct: 379 LSAALRSQNLTKSTENHRLRRSIK-KITQELSDLQQERERLEKDLEEAHREKSKGDCTIR 437
Query: 2071 QLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAV 2112
L+ ++E + + ++ + + NK+L Q+ +
Sbjct: 438 DLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI 479
Score = 33.5 bits (75), Expect = 2.5
Identities = 37/149 (24%), Positives = 69/149 (46%), Gaps = 16/149 (10%)
Query: 1844 LEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNE 1903
L+ L +I LR++LE+ + LR+ LE +++ R + + YS S +C
Sbjct: 580 LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSD-QTSYLSIC-- 636
Query: 1904 NRVLREDNRRLQAQLSHVSREHSQETES----LREALLSSRSHLQELEKELEHQKVERQQ 1959
L E+NR Q+ H S+E ++ S L + L + HL++ +L +
Sbjct: 637 ---LEENNR---FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNG 690
Query: 1960 LLEDLREKQQ-EVLHFREER--LSLQEND 1985
+ L +Q E+L +E+ + + E+D
Sbjct: 691 FPDRLASTEQTELLASKEDEDTIKIGEDD 719
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 169 bits (427), Expect = 4e-41
Identities = 357/1708 (20%), Positives = 706/1708 (41%), Gaps = 247/1708 (14%)
Query: 30 EERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRR 89
++ +Q++++AS E+ + L+ +V LK+ L++ ++D + L Q AE+
Sbjct: 203 KKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVD-VLKPLPQLEPQ--AEVFT 259
Query: 90 QFEERQQETEHVYE--LLENKIQLLQEESRLAKNEAARMAALVEAEKE-CNLELSEKLKG 146
+ E + + E V E ++ LQ+ + +N R +++ KE C L SEK
Sbjct: 260 KEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEK--- 316
Query: 147 VTKNWEDVPGDQVKPDQYTEALAQR-DKRIEELNQ----SLAAQERLVEQLSREKQQLLH 201
EAL ++ D+R++EL + +A + +L+ QL R+ + L+
Sbjct: 317 -------------------EALQEQLDERLQELEKIKDLHMAEKTKLITQL-RDAKNLIE 356
Query: 202 LLEEPTSMEVQPMTEEL-----LKQQKLNSHETTITQQSVSDSHLAELQEKIQQT----- 251
LE+ M + ++ +K++++ + I Q + L E +EK ++
Sbjct: 357 QLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEEL 416
Query: 252 -------EATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVI 304
+ T + ++ EM ++K +++S+++ ++Q + R +E+ V+
Sbjct: 417 EKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQ------QELSRVKQEVVDVM 470
Query: 305 EGQNDTMAKLREMLHQSQLGQ--------LHSSEGTSPAQQQVALLDLQS---------- 346
+ ++ + LH+ +L + L + E Q +VAL QS
Sbjct: 471 KKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKE 530
Query: 347 ---ALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASW--------- 394
+L +LE+QK + ++ + E +L D +Q + E E E S
Sbjct: 531 QQESLALEELELQK-KAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKD 589
Query: 395 ----------KHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQN-IQHLNHSL 443
KHN+E+ +++ + EL++ Q A EK ++ Q Q ++ L
Sbjct: 590 LAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKC 649
Query: 444 SHKEQLLQEFRELL---QYRDNSDKTLE---ANEMLLEKLRQRIHDKAVALERAIDEKFS 497
+++ L + +E++ + ++KTLE + LE L + + A + ++E+ S
Sbjct: 650 EQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHK-LEEELS 708
Query: 498 ALEEKEKELRQLRLAV--RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTC 555
L+++ +++Q A +++H +++ ++ +E ++Q E L+ + ++E L
Sbjct: 709 VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLK-- 766
Query: 556 QNLQWLKE--------EMETKFSRWQKEQES----IIQQLQTSLHDRNKEVEDLSATLLC 603
+ + LKE E + K S + +Q S + Q Q++ H++ K E+ A L
Sbjct: 767 ERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQ 826
Query: 604 KLGPGQSE-------IAE------ELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQ 650
KL ++E +AE ++C L + +QDL+ KQ E E +++ L Q
Sbjct: 827 KLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQ 886
Query: 651 SVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLG 710
++ ++ E+ Q L+E+ + + +R+ +++Q A+ L
Sbjct: 887 VYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQ----KLSAKEDSIHILN 942
Query: 711 KQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKER 770
++ + + + AKE + L LD A L+KEL N EL K+
Sbjct: 943 EEYETKFKNQEKKMEKVKQKAKEMQETLKKKL--LDQEAKLKKELENTALELSQKEKQFN 1000
Query: 771 ESQMELS---------ALQSMMAVQEEELQ-VQAADMESLTRNIQIKEDLIKDLQMQLVD 820
+E++ A+ + Q+E+++ + L I I E + +L +
Sbjct: 1001 AKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQE 1060
Query: 821 PEDIPAMERLTQEVLLLREKV----ASVESQGQEISGNRRQ------QLLLMLEGLVDER 870
+I E+ QEV L++K+ E +EI+ + + L + E L +
Sbjct: 1061 IHEIQLQEK-EQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKS 1119
Query: 871 SRLNEALQAERQLYSSLVKFHAHPESSERDRT-LQVELEGAQVL----RSRLEEVLGRSL 925
+ +N Q E +L + L K S ++ T LQ +L ++L + ++ E+ +
Sbjct: 1120 AHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLK 1179
Query: 926 ERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQN 985
++L + + ED S EF EE A + + +K+ A +E +
Sbjct: 1180 TTDEEFQSLKS-SHEKSNKSLEDKSLEFKKLSEELAIQ------LDICCKKTEALLEAKT 1232
Query: 986 PSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHI 1045
S +N L R QH K K +K EA ++
Sbjct: 1233 NELINIS--SSKTNAILS------RISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284
Query: 1046 RNTM-LSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAE--- 1101
+NT+ +S +L+E+ + S +IE V + + KEG ++ +E
Sbjct: 1285 QNTLNISFQQATHQLEEKENQIKSMKADIE-----SLVTEKEALQKEGGNQQQAASEKES 1339
Query: 1102 -FRKLQGKLKNAHNIINLLKEQLVLSSKE--GNSKLTPELLVHLTSTIERINTELVGSPG 1158
+L+ +L N + L+KE+L E SK +L V L ++I E S
Sbjct: 1340 CITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSL 1399
Query: 1159 KHQHQEEGNVTVRPFPRPQSLDLGATFTVDA---------HQLD---NQSQPRDPGPQSA 1206
+ Q+ EE + Q DL +F VD Q+D N+ QS
Sbjct: 1400 RKQYDEEKCELL-----DQVQDL--SFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSR 1452
Query: 1207 FSLPGST-QHLRSQLS-QCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQD 1264
F+ +T + L+ QL + K+ Y+ ++ LL E + ++ K L GE ++ D
Sbjct: 1453 FTQHQNTVKELQIQLELKSKEAYEKDEQINLLKE-----ELDQQNKRFDCLKGE--MEDD 1505
Query: 1265 SKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLA 1324
+++ +L E ++ E E+ + + E SL E +++ ++ L
Sbjct: 1506 KSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNE--VLKNYNQQKDIEHKELV 1563
Query: 1325 SSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQ----NLKSRVR 1380
+ +LG++++ RV E IL L + +KA+L+ K ++ ++KS+
Sbjct: 1564 QKLQH---FQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEE 1620
Query: 1381 SLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLES 1440
L D S E KL L+ + + + LS Q KK ES
Sbjct: 1621 ELKALEDRLES-ESAAKL---AELKRKAEQKIAAIKKQLLSQ----MEEKEEQYKKGTES 1672
Query: 1441 LIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQARE--LSYLRQKIREGRGI 1498
+S+L +L + E + EE + + ++LI ++ + +Y Q+ + +G
Sbjct: 1673 ---HLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQG- 1728
Query: 1499 CYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKD 1558
C T K +V +L + +GQ E ++ ++ + +L +H +E
Sbjct: 1729 CVQKTYEEKISVLQ-RNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEH-AEAK 1786
Query: 1559 QAGLEPLALRLSRELQEKEKVIEVLQAK 1586
Q + + L EL+EK K ++ A+
Sbjct: 1787 QHEDQSMIGHLQEELEEKNKKYSLIVAQ 1814
Score = 135 bits (339), Expect = 6e-31
Identities = 264/1316 (20%), Positives = 548/1316 (41%), Gaps = 213/1316 (16%)
Query: 12 LNDLKKENFSLKLRIYFLEERMQQKYEASRED--------IYKRNIELKVEVESLKRELQ 63
+ L+K+N ++ ++ L + + K E ++ + K N+ L++ E K+E++
Sbjct: 867 MQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMR-EGQKKEIE 925
Query: 64 DKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLEN-KIQLLQEESRLAKNE 122
Q L + LN + E + + Q ++ ++ + E+ E K +LL +E++L K
Sbjct: 926 ILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKEL 985
Query: 123 AARMAALVEAEKECNLELSEKLKGVTKNWED-VPGDQVKPDQYTEALAQRDKRIEELNQS 181
L + EK+ N ++ E + + D V + + E+L + +R ELN
Sbjct: 986 ENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRR--ELNDV 1043
Query: 182 LAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELL----KQQKLNSHETTITQQSVS 237
++ E+ + Q + E Q++ + + EV + +++L +++++N T + ++ V
Sbjct: 1044 ISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVK 1103
Query: 238 -DSHLAELQEKIQQTEA----------------------TNKILQEK--LNEMSYELKCA 272
D+ L ELQE+++Q A NK L+E L E ELK
Sbjct: 1104 QDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKML 1163
Query: 273 QESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGT 332
E +++ + L LK+ + E + L E N ++ + L +L + + +
Sbjct: 1164 AEEDKRK---VSELTSKLKTTDEEFQSLKSSHEKSNKSLED--KSLEFKKLSEELAIQLD 1218
Query: 333 SPAQQQVALLDLQS--ALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQK 390
++ ALL+ ++ + S + + + + + K+ + E E Q
Sbjct: 1219 ICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQL 1278
Query: 391 EASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQ----HLNHSLSHK 446
+ L + QQ +L+ K Q+++ +A+ + T+++ +Q + + S K
Sbjct: 1279 RQLTEEQNTLNISFQQATHQLEEKENQIKSMKAD-IESLVTEKEALQKEGGNQQQAASEK 1337
Query: 447 EQLLQEFRELLQYRDNS----DKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEK 502
E + + ++ L N+ + L+ ++ + L +++ D V L+ +I +L EK
Sbjct: 1338 ESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI-----SLSEK 1392
Query: 503 EKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLK 562
E + LR + +D E+ ++L + +++L + K +EQ+
Sbjct: 1393 EAAISSLR-----KQYDEEKC-ELLDQVQDLSFKVDTLSKEKISALEQV----------- 1435
Query: 563 EEMETKFSRWQKEQES-------IIQQLQTSLHDRNKEV--EDLSATLLCKLGPGQSEI- 612
++ KFS W+K+ +S +++LQ L ++KE +D LL + Q++
Sbjct: 1436 DDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRF 1495
Query: 613 ------AEELCQRLQRKERMLQDLLSDRNKQVLEHE-------MEIQGLLQSVSTREQES 659
E+ ++++KE L+ L + +++E E +EI+ L + + Q+
Sbjct: 1496 DCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQK 1555
Query: 660 QAAAEKLVQALM-------ERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQ 712
++LVQ L E+++ ++ + + L + + + +AE+ K+
Sbjct: 1556 DIEHKELVQKLQHFQELGEEKDNRVKEAEEKI-----LTLENQVYSMKAELETKK---KE 1607
Query: 713 TDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDL-----DTVAGLEKELSNAKEELELMAK 767
+ ++ + S+++ S + L +L +A ++K+L + EE E K
Sbjct: 1608 LEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYK 1667
Query: 768 KERESQM-----ELSALQSMMAVQEEELQ-VQAADMESL-----TRNIQI---KEDLIKD 813
K ES + +L + + + EE+L+ V+++ E+L +N+ +E+
Sbjct: 1668 KGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQ 1727
Query: 814 LQMQLVDPEDIPAMER-LTQEVLLLR----EKVASVESQGQEISGNRRQQLLLMLEGLVD 868
+Q E I ++R LT++ LL+ EK +V S + + Q+ L+ LE
Sbjct: 1728 GCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRC--QYQERLIKLEHAEA 1785
Query: 869 ER-------SRLNEALQAERQLYSSLVKFHAHPESSERD---------------RTLQVE 906
++ L E L+ + + YS +V H E + + +TLQ +
Sbjct: 1786 KQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEK 1845
Query: 907 LEGAQVLRSRLEE-----VLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEA 961
Q+L +++E V + + R+ +E L + D + T+ +EE
Sbjct: 1846 ELTCQILEQKIKELDSCLVRQKEVHRVE-MEELTSKYEKLQALQQMDGRNKPTELLEENT 1904
Query: 962 AHHSHQQLVKVAL-----------EKSLATVETQNPSFSPPSPMGGDSNRCL----QEEM 1006
S LV+ L E LA E + R L Q+E+
Sbjct: 1905 EEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQEL 1964
Query: 1007 LHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAE--LKEQMG 1064
L+ E+ Q EEK K E+E ELK + + NT L+ + E +KE +
Sbjct: 1965 EILKKEYDQEREEKIKQEQEDLELK---HNSTLKQLMREFNTQLAQKEQELEMTIKETIN 2021
Query: 1065 EAMSDGWE-IEEDKEKGEVMVETVVTKE--------------GLSESSLQAEFRKLQGKL 1109
+A E +E +E+ +++ + K+ E + A+ R LQ +L
Sbjct: 2022 KAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQL 2081
Query: 1110 KNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEE 1165
+ + +++L GN +T ++ L + + + T + S K Q E
Sbjct: 2082 E---ELQKKYQQKLEQEENPGNDNVT---IMELQTQLAQKTTLISDSKLKEQEFRE 2131
Score = 118 bits (296), Expect = 6e-26
Identities = 316/1692 (18%), Positives = 646/1692 (38%), Gaps = 303/1692 (17%)
Query: 172 DKRIEEL--NQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHET 229
D E+L N +E+L+++L R ++ L + + + ++L+++K
Sbjct: 121 DSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVT---AYQMLQREKKKLQGI 177
Query: 230 TITQQSVSDSHLAELQEKIQQTEATNKILQEKLN-------------------------- 263
Q S +AEL+E++Q + K LQE+ +
Sbjct: 178 LSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
Query: 264 --------------EMSYELKCAQESSQK------QDGTIQNLKETLKSRERETEELY-- 301
E E+ +E+ + +DGT ETL+ R + E L
Sbjct: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKR 297
Query: 302 --QVIEGQNDTMAKL---REMLHQ---------SQLGQLHSSEGTS------PAQQQVAL 341
+ I+ + L +E L + ++ LH +E T A+ +
Sbjct: 298 CKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQ 357
Query: 342 LDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHN-QEL 400
L+ + ++ + +++ + KE ++A + ++ + E +QKE S + +EL
Sbjct: 358 LEQDKGMVIAETK-RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEEL 416
Query: 401 RKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHK-EQLLQEFRELLQY 459
KAL Q+ + R +AE +I+T E+ + SL + ++ QE ++++
Sbjct: 417 EKALSTAQK----TEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKK 472
Query: 460 RDNSD--KTLEANEMLLEKLRQRIHDKAVALERAIDEKFS-ALEEKEKELRQLRLAVRER 516
K + +E L + Q + K ER E+ ALE+ + E L+++ +
Sbjct: 473 SSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSE--YLKISQEKE 530
Query: 517 DHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQ 576
+ L ++ +A + E+ LR E E T + L+ +E + +
Sbjct: 531 QQESLALEELELQKKAILTESENKLRDLQQEAETYRT---RILELESSLEKSLQENKNQS 587
Query: 577 ESIIQQLQTSLHDRNKEVE---DLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 633
+ + L+ + NKE+ + T L L Q + E Q L+++ + + L +
Sbjct: 588 KDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLRE 647
Query: 634 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 693
+ +Q E ++ + ++ E+ ++ EKL E S L + L R L +
Sbjct: 648 KCEQEKETLLKDKEIIFQAHI-EEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEE 706
Query: 694 APISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEK 753
+ Q + K +Q + D S+ + +VSI R+ EK
Sbjct: 707 LSVLKDQTDKMKQELEAKMDEQKNHHQQQVD---SIIKEHEVSIQRT-----------EK 752
Query: 754 ELSNAKEELELMAKKE----RESQMELSALQSMMAVQEEELQVQAADME-------SLTR 802
L + +LEL+ K+ +E Q + L++ + E ELQ +A ++ +
Sbjct: 753 ALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHE 812
Query: 803 NIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGN---RRQQL 859
+ E+ + LQ +L+D L E +LL ++VA VE+Q +++ + Q+
Sbjct: 813 QTKAYEEQLAQLQQKLLD---------LETERILLTKQVAEVEAQKKDVCTELDAHKIQV 863
Query: 860 LLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLE- 918
+++ L + S + + +++ Q+Y S ++ + E+++T Q+ +E ++ E
Sbjct: 864 QDLMQQLEKQNSEMEQKVKSLTQVYESKLE----DGNKEQEQTKQILVEKENMILQMREG 919
Query: 919 -----EVLGR-------SLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSH 966
E+L + S+ LN + + + E ++++++
Sbjct: 920 QKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLL--DQ 977
Query: 967 QQLVKVALEKSLATVETQNPSFSPPSPMGGDSN-----------RCLQEEMLHLRAEFHQ 1015
+ +K LE + + + F+ +N Q+E + E H+
Sbjct: 978 EAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHR 1037
Query: 1016 H------------LEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQM 1063
L ++ + +E+ E++ Q +E V+ ++ +L E E+ +++
Sbjct: 1038 RELNDVISIWEKKLNQQAEELQEIHEIQLQEKE---QEVAELKQKILLFGCEKEEMNKEI 1094
Query: 1064 GEAMSDGWEIEEDKEKGEVMVE-----TVVTKEGLSESSLQAEFRKLQGKLKNAHNIINL 1118
+G +++D E+ + V E+ L+A KL+ L +
Sbjct: 1095 TWLKEEG--VKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTF 1152
Query: 1119 LKEQLV---LSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPR 1175
L+EQLV + ++E K++ EL L +T E + ++ E+ ++ +
Sbjct: 1153 LQEQLVELKMLAEEDKRKVS-ELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
Query: 1176 PQSLDLG-------ATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQ 1228
++ L A ++L N S + T + S++S C+ R
Sbjct: 1212 ELAIQLDICCKKTEALLEAKTNELINISSSK-------------TNAILSRISHCQHRTT 1258
Query: 1229 DLQEKLLLSEATVFAQANELEKYRVMLTGESLV---------------KQDSKQIQVDLQ 1273
++E LL+ TV +ELE LT E + K ++ D++
Sbjct: 1259 KVKEALLIKTCTV----SELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIE 1314
Query: 1274 DLGYETCGRSENEAEREETTSPE----CEEHNSLKEMVLMEGLCSEQGRRGSTLASSSER 1329
L E + +++ S + + L E + L E+ + SS +
Sbjct: 1315 SLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSK 1374
Query: 1330 KPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQN-----ANKVIQNLKSRVRSLSV 1384
+ + + Q + K I LRK + K +L + + KV K ++ +L
Sbjct: 1375 QLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQ 1434
Query: 1385 TSDYSSSLERPWKLRAVG--------------TLEGSSPHSVPDEDE------------- 1417
D+S+ WK +A LE S + +++
Sbjct: 1435 VDDWSNKFSE-WKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNK 1493
Query: 1418 ------GWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLE-EKLAEELRSASW 1470
G + D + +L+S R+ +LE + + +E E L E L++ +
Sbjct: 1494 RFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQ 1553
Query: 1471 P------------GKYDSLIQDQARELSYLRQKIREGRGICYLI----------TRHAKD 1508
+ L +++ + +KI Y + H
Sbjct: 1554 QKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNL 1613
Query: 1509 TVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSK-----LSTKDHKSEKDQAGLE 1563
+VKS E+ L++ ++ L +LA+ + E+ + LS + K E+ + G E
Sbjct: 1614 SVKSKEEELKA--LEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTE 1671
Query: 1564 PLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDM 1623
L+ +LQE+E+ + +L+ KL +S+ S S L RS + + +++ EA S
Sbjct: 1672 SHLSELNTKLQEREREVHILEEKL--KSVESSQSETLI-VPRSAKNVAAYTEQEEADSQG 1728
Query: 1624 DIVSEYTHYEEK 1635
+ YEEK
Sbjct: 1729 CVQKT---YEEK 1737
Score = 58.2 bits (139), Expect = 1e-07
Identities = 253/1262 (20%), Positives = 470/1262 (37%), Gaps = 214/1262 (16%)
Query: 912 VLRSRLEEVLGR--SLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL 969
+ RS +E L R S E LNRL+ ++ A+ D D +E D + + + Q +
Sbjct: 84 LFRSSSKESLVRTSSRESLNRLDLDSS---TASFDPPSDMDSEAEDLVGNSDSLNKEQLI 140
Query: 970 VKVA-LEKSLATVETQNPSFSPPSPMGGDSNRCLQ-------EEMLHLRAEFHQHLEEKR 1021
++ +E+SL++ + M + LQ ++ L AE + L+ +
Sbjct: 141 QRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQ 200
Query: 1022 KAEEELKE-LKAQIEEAG-FSSVSHIRNTMLSLCLENAELKEQMG------EAMSDGWEI 1073
+A++ L+E A +EE + SV + ++L L N + + E ++ +
Sbjct: 201 QAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTK 260
Query: 1074 EEDKEK-GEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNS 1132
EE+ E GE +VE +G S +L+ LQ ++K N++ KE + S KE +
Sbjct: 261 EENPESDGEPVVE-----DGTSVKTLET----LQQRVKRQENLLKRCKET-IQSHKEQCT 310
Query: 1133 KLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVT----VRPFPRPQSLDLGATFTVD 1188
LT E ER+ EL H ++ +T + D G
Sbjct: 311 LLTSEKEALQEQLDERLQ-ELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAET 369
Query: 1189 AHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANEL 1248
Q+ + ++ LRS++ Q + ++L+E+ SE F EL
Sbjct: 370 KRQMHETLEMKEE----------EIAQLRSRIKQMTTQGEELREQKEKSERAAF---EEL 416
Query: 1249 EKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVL 1308
EK L+ ++ ++++ ++ + + + E TS E E + +E+
Sbjct: 417 EK---ALSTAQKTEEARRKLKAEMDE-----------QIKTIEKTSEE-ERISLQQELSR 461
Query: 1309 MEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNA 1368
++ + ++ S + +K E +L ++E+ L K ++ + + Q
Sbjct: 462 VKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQ-----------ELTKKLQTREREFQEQ 510
Query: 1369 NKV-IQNLKSRVRSLSVTSDYSSSL---ERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGT 1424
KV ++ +S +S + SL E + +A+ T + + E E
Sbjct: 511 MKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAE------- 563
Query: 1425 GAFYSPGLQAKKDLESLIQR--------VSQLEAQLPKNGLE-----EKLAEELRS---- 1467
+ + L+ + LE +Q LEA+ K+ E EK EL S
Sbjct: 564 -TYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQ 622
Query: 1468 --ASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYY 1525
A W K L Q E+ LR+K + + E LL+ +I +
Sbjct: 623 QDALWTEKLQVLKQQYQTEMEKLREKCEQEK-----------------ETLLKDKEIIFQ 665
Query: 1526 LGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQA 1585
A ++ E+ KL K Q LE L+ LS L+ + K+ E L
Sbjct: 666 ---------AHIEEMNEKTLEKLDVK-------QTELESLSSELSEVLKARHKLEEELSV 709
Query: 1586 KLDARSLTPSSSHALSDSHRS--PSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSD 1643
D A D ++ + E E + + + D
Sbjct: 710 LKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERD 769
Query: 1644 SIHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKL 1703
H H A + + + S+G ++++ + Q+ E +A+ +L
Sbjct: 770 K-HLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYE-------EQL 821
Query: 1704 ASLPQAPLPSAPSSFLPFSPTGPLLLG----CCETPVVSLAEAQQELQMLQKQLGESAST 1759
A L Q L L + C E + + Q +Q L+KQ E
Sbjct: 822 AQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKI-QVQDLMQQLEKQNSEMEQK 880
Query: 1760 VPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKG 1819
V S + + LE + + Q +E ++ G + +++ QK
Sbjct: 881 VK--SLTQVYESKLEDGNKEQEQTKQI------LVEKENMILQMREGQKKEIEILT-QKL 931
Query: 1820 SVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTST 1879
S D S++ LN EE+ + +N +++E+ ++E L+ +L
Sbjct: 932 SAKED-----SIHILN---------EEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQ 977
Query: 1880 -ARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSH-VSREHSQETESLREALL 1937
A+ + N LE + N + E + A +S VSR + + E +
Sbjct: 978 EAKLKKELEN---TALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 1034
Query: 1938 SSRSHLQEL----EKELEHQKVERQQLLE-DLREKQQEVLHFREERLSLQENDSRLQHKL 1992
R L ++ EK+L Q E Q++ E L+EK+QEV +++ L + ++
Sbjct: 1035 VHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI 1094
Query: 1993 VLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVR 2052
L+++ ++ LQ +L+ A H L+ D + L A +
Sbjct: 1095 TWLKEEGVKQDTTLNELQEQLKQKSA-----------------HVNSLAQDETKLKAHLE 1137
Query: 2053 ALRGQLEQSIQGNNCLR---LQLQQQLESGAGKASLSPSSIN------QNFPASTDPGNK 2103
L L +S++ N L+ ++L+ E K S S + Q+ +S + NK
Sbjct: 1138 KLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNK 1197
Query: 2104 QL 2105
L
Sbjct: 1198 SL 1199
Score = 46.6 bits (109), Expect = 3e-04
Identities = 72/328 (21%), Positives = 138/328 (42%), Gaps = 55/328 (16%)
Query: 14 DLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTW 73
+L +EN K + + ++ ++ EA D L+ ++ +RE Q + + +
Sbjct: 1898 ELLEENTEEKSKSHLVQPKLLSNMEAQHND-------LEFKLAGAEREKQKLGKEIVRLQ 1950
Query: 74 ADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARM------A 127
D+ L +++ EL +E QE E KI+ QE+ L N +
Sbjct: 1951 KDLRMLRKEHQQELEILKKEYDQEREE-------KIKQEQEDLELKHNSTLKQLMREFNT 2003
Query: 128 ALVEAEKECNLELSEKL-KGVTKNWEDVPGDQVKPDQYTEALAQRD-------KRIEEL- 178
L + E+E + + E + K E + Q + +Q + +A++D KR EE+
Sbjct: 2004 QLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEIL 2063
Query: 179 ---NQSLAAQER----LVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTI 231
+ + A+ R +E+L ++ QQ L E P + V +++ Q + +TT+
Sbjct: 2064 DAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNV-----TIMELQTQLAQKTTL 2118
Query: 232 TQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLK 291
+SDS L E QE +Q L+++L + + + + G + + +L
Sbjct: 2119 ----ISDSKLKE-QEFREQIHN----LEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLF 2169
Query: 292 SRERETEELYQVI-----EGQNDTMAKL 314
E E L +V+ + TMAK+
Sbjct: 2170 GEPTEFEYLRKVLFEYMMGRETKTMAKV 2197
Score = 45.1 bits (105), Expect = 8e-04
Identities = 114/538 (21%), Positives = 209/538 (38%), Gaps = 79/538 (14%)
Query: 1842 DLLEEHLGEIRNLRQRLEESICINDRLREQLE----------HRLTSTAR----GRGSTS 1887
+ LE EI LR R+++ + LREQ E + STA+ R
Sbjct: 375 ETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLK 434
Query: 1888 NFYSQGLESIPQLCNENRV-LREDNRRLQAQLSHVSREHSQET----ESLREALLSSRSH 1942
+ +++I + E R+ L+++ R++ ++ V ++ S+E + L E L+ +
Sbjct: 435 AEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKE- 493
Query: 1943 LQELEKELEHQKVERQQLLEDLREKQQ----EVLHFREERLSLQENDSRLQHKLVL---- 1994
QEL K+L+ ++ E Q+ ++ EK Q ++ +E++ SL + LQ K +L
Sbjct: 494 -QELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESE 552
Query: 1995 -----LQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDA---CHQIPLSSDLSH 2046
LQQ+ E + L+S L+ N K L A L+A H ++ +
Sbjct: 553 NKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDL-AVHLEAEKNKHNKEITVMVEK 611
Query: 2047 LVAEVRALRGQLEQS-IQGNNCLRLQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQL 2105
E+ +L+ Q + + L+ Q Q ++E K K+
Sbjct: 612 HKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCE----------------QEKET 655
Query: 2106 LLQDSAVSPPVRDVGMNSPAL----VFPSSASSTPGSETPIINRANGLGLDTSPVMKTPP 2161
LL+D + MN L V + S + ++ + L + S +
Sbjct: 656 LLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTD 715
Query: 2162 KL--EGDATDGSFANKHGRHVIGHIDDY--------SALRQQIAEGKLLVK-KIVSLVRS 2210
K+ E +A N H + V I ++ AL+ QI + +LL+K + L
Sbjct: 716 KMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEH 775
Query: 2211 ACSFPGLEA-----QGTEVLGSKGIHELRSSTSALHHALEESASLLTMFWRAALPSTHIP 2265
LEA +G S + +S SA H + L + L
Sbjct: 776 QAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETER 835
Query: 2266 VLPGKVGESTERELLELRTKVSKQERLLQSTTEHLKNANQQKESMEQFIVSQLTRTHD 2323
+L K E + ++ T++ + +Q + L+ N + E V LT+ ++
Sbjct: 836 ILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQK----VKSLTQVYE 889
Score = 39.3 bits (90), Expect = 0.046
Identities = 46/191 (24%), Positives = 76/191 (39%), Gaps = 34/191 (17%)
Query: 1904 NRVLREDNRRLQAQLSHVSREHSQE-TESLREALLSSRSHLQELEKELEHQKVER----- 1957
N ++ + + A LS +S H Q T ++EALL + ELE +L E+
Sbjct: 1233 NELINISSSKTNAILSRIS--HCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNI 1290
Query: 1958 --QQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQI 2015
QQ L EK+ ++ + + SL LQ + QQ EK+ L+ EL
Sbjct: 1291 SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL-- 1348
Query: 2016 YEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQ 2075
+ + A +L + +L E+ +L QL L +QLQ
Sbjct: 1349 --------SENINAVTL-------MKEELKEKKVEISSLSKQLTD-------LNVQLQNS 1386
Query: 2076 LESGAGKASLS 2086
+ +A++S
Sbjct: 1387 ISLSEKEAAIS 1397
Score = 36.2 bits (82), Expect = 0.39
Identities = 38/144 (26%), Positives = 69/144 (47%), Gaps = 11/144 (7%)
Query: 1899 QLCNENRVLREDNRRLQAQL-SHVSREHSQETESLREALLSSRS---HLQELEKELEHQK 1954
+L EN + + +Q +L S++ +H+ L A + + L+K+L +
Sbjct: 1898 ELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLR 1957
Query: 1955 VERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQS-EL 2013
E QQ LE L+++ + REE++ ++ D L+H L Q E QL + Q E+
Sbjct: 1958 KEHQQELEILKKEYDQE---REEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEM 2014
Query: 2014 QIYEALYGNSKKGLKAYSLDACHQ 2037
I E + N + ++A L++ HQ
Sbjct: 2015 TIKETI--NKAQEVEAELLES-HQ 2035
Score = 34.7 bits (78), Expect = 1.1
Identities = 43/196 (21%), Positives = 80/196 (40%), Gaps = 16/196 (8%)
Query: 1843 LLEEHLGEIRNLR----QRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIP 1898
L +EH E+ L+ Q EE I + +E LE + ST + F +Q +
Sbjct: 1956 LRKEHQQELEILKKEYDQEREEKI---KQEQEDLELKHNSTLKQL--MREFNTQLAQKEQ 2010
Query: 1899 QLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEH----QK 1954
+L ++E + Q + + H +ET L + + L+ K E ++
Sbjct: 2011 EL---EMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDARE 2067
Query: 1955 VERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQ 2014
E + DL+ + +E+ +++L +EN ++ LQ Q +K L + + Q
Sbjct: 2068 EEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQ 2127
Query: 2015 IYEALYGNSKKGLKAY 2030
+ N + LK Y
Sbjct: 2128 EFREQIHNLEDRLKKY 2143
Score = 33.9 bits (76), Expect = 1.9
Identities = 43/188 (22%), Positives = 85/188 (45%), Gaps = 32/188 (17%)
Query: 1907 LREDNRR---LQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLED 1963
L + N+R L+ ++ + ++ +L L S + + ELE + + +E + L E
Sbjct: 1488 LDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEV 1547
Query: 1964 LR-----------EKQQEVLHFREERLSLQENDSRL---QHKLVLLQQQCEEKQQLFESL 2009
L+ E Q++ HF+E +E D+R+ + K++ L+ Q + E+
Sbjct: 1548 LKNYNQQKDIEHKELVQKLQHFQELG---EEKDNRVKEAEEKILTLENQVYSMKAELETK 1604
Query: 2010 QSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLR 2069
+ EL+ + ++ LKA + L S+ + +AE L+ + EQ I ++
Sbjct: 1605 KKELEHVNLSVKSKEEELKAL------EDRLESESAAKLAE---LKRKAEQKIA---AIK 1652
Query: 2070 LQLQQQLE 2077
QL Q+E
Sbjct: 1653 KQLLSQME 1660
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 158 bits (399), Expect = 7e-38
Identities = 460/2328 (19%), Positives = 918/2328 (39%), Gaps = 384/2328 (16%)
Query: 12 LNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIE-LKVEVESLKRELQDKKQHLD 70
L ++ E +L+ +I LE ++ + S E Y + L+++ E+L E+++ LD
Sbjct: 630 LTQMESEKENLQSKINHLETCLKTQQIKSHE--YNERVRTLEMDRENLSVEIRNLHNVLD 687
Query: 71 KTWADVEN-----LNSQNEAELRRQFEERQ---------------QETEHVYELLENKIQ 110
+VE + Q +AE Q +++ ++ EH +LL N+I
Sbjct: 688 SKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIM 747
Query: 111 --------LLQEESRLAKNEAARMAALVEAEK-ECNLELSEKLKGVTKNWEDVPGDQ--- 158
L E L ++ A+LV E + +L ++ + ++ ++ G+Q
Sbjct: 748 DKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSM 807
Query: 159 --------VKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEE--PTS 208
++ DQ + A R++ L SL +Q+++ L ++ ++L+ + E
Sbjct: 808 PSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENL 867
Query: 209 MEVQPMTEELLKQ--QKLNS-HETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEM 265
M+ + M + + + Q+++ E T Q+V L+ L+ K ++ + N ++ + E+
Sbjct: 868 MKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEI 927
Query: 266 SYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQV-------IEGQNDTMAKLREML 318
ELK + + +Q L ETL ++E + + + +N T+ ++ L
Sbjct: 928 Q-ELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASL 986
Query: 319 HQSQLGQLHSSEGTSP----------------AQQQVALLDLQSALFCSQLEIQKLQRVV 362
+Q ++ + SE + Q+++ LL + ++ + +
Sbjct: 987 NQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAA 1046
Query: 363 RQKERQLADA-KQCVQFVEAAAHESEQQKEASWKHNQELRKAL-------QQLQEELQNK 414
++K +L +C E +E EQ KEA K +QE L Q L EL+
Sbjct: 1047 QEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETV 1106
Query: 415 SQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ-EFRELLQYRDNSDKTL----EA 469
Q LR+ + N +++ ++ +L ++ +Q E +LLQ + K + E
Sbjct: 1107 QQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHEC 1166
Query: 470 NEMLLEKLRQRIHDKAV--------------ALERAIDEKFSALEEKEKELRQLRLAVRE 515
+ E +R + ++ E ++D + L + E LR L ++E
Sbjct: 1167 QNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQE 1226
Query: 516 RD-------HDLERLR-DVLSSNEATMQSMESLLRAKGLEVE----------QLSTTCQN 557
+ H+L+ +R D+ +SN MQS E + K E++ +LST+ +
Sbjct: 1227 SEKEKECLQHELQTIRGDLETSNLQDMQSQE-ISGLKDCEIDAEEKYISGPHELSTSQND 1285
Query: 558 LQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELC 617
L+ ++T ++ E E I + LQ ++ E+ D + + ++AEE+
Sbjct: 1286 NAHLQCSLQTTMNKLN-ELEKICEILQAEKYELVTELNDSRSECIT----ATRKMAEEV- 1339
Query: 618 QRLQRKERMLQDLLSDRNKQVLE--------------HEMEIQGLLQS-----VSTREQE 658
+L + ++L D + +++E H + + L +S ++ ++E
Sbjct: 1340 GKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKE 1399
Query: 659 SQAAAEKLVQALMERNSELQALRQYLGGRDSLMS--QAPISNQQAE--VTPT------GC 708
Q +L + + SE + L S MS Q + + +AE V T G
Sbjct: 1400 VQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGD 1459
Query: 709 LGKQTDQGSMQ--IPSRD-----DSTSLTAKEDVSIPRSTL---GDLDTVAGLEKELSN- 757
L K+ G + +PS DS+SL++ D S R+ L GD+ ++ LE +S
Sbjct: 1460 LVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSAN 1519
Query: 758 ---------AKEELELMAKKERESQME--LSALQSMMAVQEEELQVQAADMES--LTRNI 804
+ + E + +KE S + L+S+ V + L+ MES + +N
Sbjct: 1520 QCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNK 1579
Query: 805 QIKE-DLIKDLQMQLVD-------PEDIPAMERLTQEVLLLREKVASVESQGQEISGNRR 856
+I+E + + + Q +D E+ ++LT L + K+A+ + Q +++S
Sbjct: 1580 EIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLS-LEL 1638
Query: 857 QQLLLMLEGL-VDERSRLN----EALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQ 911
+ L L+GL + RS L +A+Q + + K H E++ER V Q
Sbjct: 1639 EVARLQLQGLDLSSRSLLGIDTEDAIQGRNES-CDISKEHTS-ETTERTPKHDVH----Q 1692
Query: 912 VLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVK 971
+ ++ L +E++ + G +G+ + DT+ E + + + +L
Sbjct: 1693 ICDKDAQQDLNLDIEKITETGAVKPTG-ECSGEQSPDTNYEPPGEDKTQGSSECISEL-- 1749
Query: 972 VALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEM--LHLRAE---------FHQHLEEK 1020
SFS P+ + QE++ L LR + H +
Sbjct: 1750 ---------------SFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRD 1794
Query: 1021 RKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENA-ELKEQMGEAMSDGWEIEEDKE- 1078
RK E L E+K S H++ L +E EL++ +GE + ++ E E
Sbjct: 1795 RKVESLLNEMKE------LDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEY 1848
Query: 1079 ---KGEVMVETVVTKEGL-SESSLQAEFRKLQGKLKNAHNIINLLKEQLV-----LSSKE 1129
+ +++ V T EGL S+ + A+ + N + + KE+ + LS
Sbjct: 1849 FSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIR 1908
Query: 1130 GNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDA 1189
++L + +E + TE + ++++++ V + + + T +
Sbjct: 1909 SEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLE--------EELSVVTSER 1960
Query: 1190 HQL----DNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQA 1245
+QL D S+ Q + + TQ L S S+C Q A+A
Sbjct: 1961 NQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQ-------------VAEA 2007
Query: 1246 NELEKYRVMLTGESLVKQ---DSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNS 1302
EK ++ T S V + D +Q LQ L ++ S + E E + + N
Sbjct: 2008 EVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELEN----QIAQLNK 2063
Query: 1303 LKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEF--RVYGKSENILVLRKDIKD 1360
KE+++ E + S + K LE L ++ EF R+ E + LR+ I+
Sbjct: 2064 EKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEK 2123
Query: 1361 LKAQLQNANK----VIQNLKSRVRSLSVTSDYSSSLERPWKL----RAVGTLEGSSPHSV 1412
L+ +++ K + + LK R R D +LER ++ + + L+ + +
Sbjct: 2124 LRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAE 2183
Query: 1413 PDEDEGWLSD---GTGAFYSPGLQAKKDLESLIQRVSQLEAQLP---------KNGLEEK 1460
+ + + + F + + + E+L +++ + + QL K+ LEEK
Sbjct: 2184 VETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEK 2243
Query: 1461 LAEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVK-------SF 1513
E++ ++Q+Q +EL+ + + I + ++ S
Sbjct: 2244 EQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSI 2303
Query: 1514 EDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSREL 1573
E L + D +QL + + L ++ + + E + E AL E
Sbjct: 2304 EKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAAL----EA 2359
Query: 1574 QEKEKVIEVLQAKLDA--RSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTH 1631
+ + +E L+AK++ +SL ++ + T+ L E E S+++I++
Sbjct: 2360 ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINS--- 2416
Query: 1632 YEEKKASPSHSDSIHHSSHSAVLSSKPSSTSAS--QGAKAESNSNPISLPTPQNTPKEAN 1689
S + + V + SST+ Q E N +L Q K
Sbjct: 2417 --------SFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKE 2468
Query: 1690 QAHSGFHFHSIPKLASLPQAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLAEAQQELQML 1749
Q S + A L Q L A ++++ + L+ E L + +E+ L
Sbjct: 2469 QNLSSQVECLELEKAQLLQG-LDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRL 2527
Query: 1750 QKQLGESASTVPPASTA----------TLLSNDLEADSSYYLNSAQPHSPP-RGTIELGR 1798
+ Q+ + V S L +L + + Q + + T+E
Sbjct: 2528 KNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLE--- 2584
Query: 1799 ILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQLNSKPTG------------ADLLEE 1846
+L+ Y + ++ + K +S V ++ +K T A+L EE
Sbjct: 2585 VLQSSYKNLENELELTKMDK------MSFVEKVNKMTAKETELQREMHEMAQKTAELQEE 2638
Query: 1847 HLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNE--- 1903
GE L L+ + ++QL+ + + S + +E ++ E
Sbjct: 2639 LSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAE 2698
Query: 1904 -NRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQ---- 1958
L E ++ QA L ++++ E ++ RE L S L + E++ K ++
Sbjct: 2699 YQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNN 2758
Query: 1959 ------QLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSE 2012
Q+LE+L++ + + L + + L++ + R Q K+ LL + C++ ++ E LQ E
Sbjct: 2759 SLKATTQILEELKKTKMDNLKYVNQ---LKKENERAQGKMKLLIKSCKQLEEEKEILQKE 2815
Query: 2013 LQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQ 2060
L +A K G + + + L E++ L+ LE+
Sbjct: 2816 LSQLQAAQEKQKTG-----------TVMDTKVDELTTEIKELKETLEE 2852
Score = 144 bits (363), Expect = 1e-33
Identities = 331/1673 (19%), Positives = 646/1673 (38%), Gaps = 308/1673 (18%)
Query: 35 QKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEA--ELRRQFE 92
Q+ E + + K + + +++SL+ LQ +KQ ++ + NL +N+ E+ E
Sbjct: 21 QELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLE 80
Query: 93 ERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKG-----V 147
+ +Q+ H ++ E+++ + + K + + L + K C EL + V
Sbjct: 81 KTKQKISHELQVKESQVNFQEGQLNSGKKQIEK---LEQELKRCKSELERSQQAAQSADV 137
Query: 148 TKNWEDVPGD----QVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQL----SREKQQL 199
+ N + P + P QY D + E+ N+ + ++RL ++ +++ Q
Sbjct: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLK-EKYNKEVEERKRLEAEVKALQAKKASQT 196
Query: 200 L--------HLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEK---- 247
L + S V +E ++ + T ++ S S+ + QE
Sbjct: 197 LPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSR 256
Query: 248 -----------------------IQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQ 284
+ Q +A N+ L+ K+NE+ L+ ++ + Q Q
Sbjct: 257 STLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQ 316
Query: 285 NLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDL 344
L+ L+ + E E +V+ D + + Q+ S++ T+ Q+ L L
Sbjct: 317 ELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQA------STKYTALEQK---LKKL 367
Query: 345 QSALFCSQLEIQK----LQRVVRQKERQLADA------------KQCVQFVEAAAHESEQ 388
L C + + L++ +++KE++ + ++C+Q E +Q
Sbjct: 368 TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQ 427
Query: 389 QKEASWKHNQELRKAL---QQLQEELQNKSQQL----RAWEAE--KYNEIRTQEQNIQHL 439
K EL K QQL+ L+ Q+L +A++A K NE+R + ++
Sbjct: 428 AKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKE 487
Query: 440 NHSL-SHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSA 498
N+ L SH EQ +E L N + L ++ E+++ + + L R + EK +
Sbjct: 488 NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETML-RDLQEKINQ 546
Query: 499 LEEKEKELRQLRLAV--------------RERDHDLERLRDVLSSNEATMQSMESLLRAK 544
+E L +L+LAV ++R+H +E+L D LS E +++ S L K
Sbjct: 547 -QENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELK 605
Query: 545 GLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCK 604
E E+L +E +T FS W+ E E ++ Q+++ + ++ L L
Sbjct: 606 KKEYEEL-----------KEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCL--- 651
Query: 605 LGPGQSEIAEELCQRLQRKE----------RMLQDLLSDRNKQVLEHEMEIQGLLQSVST 654
Q + E +R++ E R L ++L ++ +V ++ L Q
Sbjct: 652 --KTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEF 709
Query: 655 REQESQAAAEKLVQALMERNSELQALRQYLG--GRDSLMSQAPISNQQAEVTPTGCLGKQ 712
+Q+ Q E + + +++ L L + + + AE L K
Sbjct: 710 SDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS 769
Query: 713 TDQGSMQIPSRDDSTSLTA-KEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERE 771
D + + + D SL A + ++ S + + E S + E + K
Sbjct: 770 KD--ASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI 827
Query: 772 SQMELSALQSMMAVQEE---ELQVQAADMESLTRNIQIKEDLIKDLQM------------ 816
Q + +L+ + Q++ +LQ Q ++ + +I+E+L+K QM
Sbjct: 828 LQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKG--EIEENLMKAEQMHQSFVAETSQRI 885
Query: 817 ----------QLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL 866
Q V E + A+E +E+ LL +KV + +++ QE+ + +LE
Sbjct: 886 SKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNH-----LLEDS 940
Query: 867 VDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEV-LGRSL 925
+ E L+E L E++ SS++ + E+E L+E+ +
Sbjct: 941 LKELQLLSETLSLEKKEMSSIISLNKR------------EIEELTQENGTLKEINASLNQ 988
Query: 926 ERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEA------------AHHSHQQLVKVA 973
E++N ++ + D+ E + +E +D ++E A+ Q K A
Sbjct: 989 EKMNLIQKSESFANYI--DEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAA 1046
Query: 974 LEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQ 1033
EK+ CL E L E ++ E+LKE A+
Sbjct: 1047 QEKN-------------------SKLECLLNECTSL-------CENRKNELEQLKEAFAK 1080
Query: 1034 IEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGL 1093
+ + ++ +L LE +++ + M+D + E G + E + KE
Sbjct: 1081 EHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDN-QNNSKSEAGGLKQEIMTLKEEQ 1139
Query: 1094 SE-----SSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSK-----LTPELLVHLT 1143
++ + L E +L +K H NL E + S KE S+ P++ + +
Sbjct: 1140 NKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVK 1199
Query: 1144 S-TIERINTELV-------GSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLD-- 1193
+++ N +LV K Q E+ ++ + DL + D +
Sbjct: 1200 EISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEIS 1259
Query: 1194 -------NQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQAN 1246
+ + GP + HL+ L + +L++ + +A +
Sbjct: 1260 GLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVT 1319
Query: 1247 EL---------------EKYRVMLTGESLVKQDSKQIQVDL-QDLGYETCGRSENEAERE 1290
EL E+ +L ++ DS + +L +D+ G N E+
Sbjct: 1320 ELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPN--EQH 1377
Query: 1291 ETTSPECEEHNSLKEMVL--MEGLCSEQGRRGSTLASSSERKPLENQ----LGKQEEFRV 1344
+ +E NS + + L E + L+ SE K L +Q K E +
Sbjct: 1378 PVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQT 1437
Query: 1345 YG---KSENILV---LRKDIKDL--KAQLQNANKVIQNL-------KSRVRSLSVTSDYS 1389
Y K+EN+++ LR DL + QL ++ +L S + SL +S Y
Sbjct: 1438 YVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYR 1497
Query: 1390 SSLERPWKLRAVGTLEGSSPHSVPDEDEGWLS----DGTGAFYSPGLQAK--KDLESLI- 1442
+ LE+ + + LEG+ + DE + S + +P AK ++LESL
Sbjct: 1498 ALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCE 1557
Query: 1443 ---QRVSQLEAQLPKNG-LEEKLAEELRSASWPGKYDSLIQDQARELSYLRQK 1491
Q + +LE ++ G ++ K +EL + L+ + +EL LR++
Sbjct: 1558 VYRQSLEKLEEKMESQGIMKNKEIQEL---------EQLLSSERQELDCLRKQ 1601
Score = 105 bits (262), Expect = 5e-22
Identities = 146/691 (21%), Positives = 310/691 (44%), Gaps = 75/691 (10%)
Query: 8 LSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQ 67
+++ L + ++EN SLK ++ LE +Q E ++E + K EVE+LK ++++ +
Sbjct: 2138 IAEKLKERERENDSLKDKVENLERELQMS-EENQELVILDAENSKAEVETLKTQIEEMAR 2196
Query: 68 HLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMA 127
L D+ L S+ E L +Q +E+Q + + +LL + LL+E+ E A +
Sbjct: 2197 SLKVFELDLVTLRSEKE-NLTKQIQEKQGQLSELDKLLSSFKSLLEEK------EQAEIQ 2249
Query: 128 ALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQER 187
E++ + L +LK + + + GDQ ++L D IEE +Q + E+
Sbjct: 2250 IKEESKTAVEM-LQNQLKELNEAVAALCGDQEIMKATEQSL---DPPIEEEHQLRNSIEK 2305
Query: 188 LVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEK 247
L +L ++++ L +L++ E +LLK ++ + E + + H A +
Sbjct: 2306 LRARLEADEKKQLCVLQQLKESEHH---ADLLK-GRVENLERELEIARTNQEHAA---LE 2358
Query: 248 IQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQ 307
+ ++ + L+ K+ M+ L+ + TI++ KE L + ++ +E +E
Sbjct: 2359 AENSKGEVETLKAKIEGMTQSLR----GLELDVVTIRSEKENLTNELQKEQERISELEII 2414
Query: 308 NDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKER 367
N + + + Q ++ Q+ T+ Q L +L + + Q + KE+
Sbjct: 2415 NSSFENILQEKEQEKV-QMKEKSSTAMEMLQTQLKELNERV----AALHNDQEACKAKEQ 2469
Query: 368 QLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYN 427
L+ +C++ +A + + + ++ L+ ++ L +E+++ Q+L
Sbjct: 2470 NLSSQVECLELEKAQLLQGLDEAKNNY---IVLQSSVNGLIQEVEDGKQKL--------- 2517
Query: 428 EIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVA 487
+++ I L + + +EQL+ + + +E L ++ + + V
Sbjct: 2518 --EKKDEEISRLKNQIQDQEQLVSKLSQ-----------VEGEHQLWKEQNLELRNLTVE 2564
Query: 488 LERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLE 547
LE +K L+ K L+ ++ +LE ++ ++ + + + AK E
Sbjct: 2565 LE----QKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETE 2620
Query: 548 VE-QLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTS---LHDRNKEVEDLSATLLC 603
++ ++ Q L+EE+ + +R E + +++++++S L + E +L +L C
Sbjct: 2621 LQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDC 2680
Query: 604 -------KLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTRE 656
K G + EIAE RL E+ Q LL D NKQ +E+EIQ + ++++E
Sbjct: 2681 MHKDQVEKEGKVREEIAEYQL-RLHEAEKKHQALLLDTNKQ---YEVEIQTYREKLTSKE 2736
Query: 657 Q---ESQAAAEKLVQALMERNSELQALRQYL 684
+ + + L + E N+ L+A Q L
Sbjct: 2737 ECLSSQKLEIDLLKSSKEELNNSLKATTQIL 2767
Score = 102 bits (253), Expect = 6e-21
Identities = 238/1106 (21%), Positives = 449/1106 (40%), Gaps = 187/1106 (16%)
Query: 15 LKKENFSLKLRIYFLEERM------QQKYEASREDIYKRNIELKVEVESLKRELQDKKQH 68
L+K+N + + I LEE + + + + + K+ L + L ++++K Q
Sbjct: 1935 LEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTAL----DQLSEKMKEKTQE 1990
Query: 69 LDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAA 128
L+ ++ + EAE++ + E Q + V ELL++K L ++ L K+ A
Sbjct: 1991 LESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLT 2050
Query: 129 LVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERL 188
E E + +L+++ + + K E + + D E+LN S A + L
Sbjct: 2051 KCELENQI-AQLNKEKELLVKESESLQARLSESD------------YEKLNVSKALEAAL 2097
Query: 189 VEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKI 248
VE+ L T EV + + K + I H+A EK+
Sbjct: 2098 VEKGE------FALRLSSTQEEVHQLRRGIEKLR------VRIEADEKKQLHIA---EKL 2142
Query: 249 QQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLK---ETLKSRERETEELYQVIE 305
++ E N L++K+ + EL+ ++E+ + +N K ETLK++ E +V E
Sbjct: 2143 KERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFE 2202
Query: 306 GQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQK 365
T+ +E L + Q+ +G Q++ LD + F S LE +K Q ++ K
Sbjct: 2203 LDLVTLRSEKENLTK----QIQEKQG------QLSELDKLLSSFKSLLE-EKEQAEIQIK 2251
Query: 366 ERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQ-----LQEE--LQNKSQQL 418
E ++K V+ ++ E + A+ +QE+ KA +Q ++EE L+N ++L
Sbjct: 2252 E----ESKTAVEMLQNQLKEL-NEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKL 2306
Query: 419 RA-WEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSD-KTLEANEMLLEK 476
RA EA++ ++ +Q + +H+ K ++ REL R N + LEA
Sbjct: 2307 RARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEA------- 2359
Query: 477 LRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQS 536
+ + L+ I+ +L E ++ +R ++L++ ++ +S E S
Sbjct: 2360 --ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSS 2417
Query: 537 MESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVED 596
E++L+ K E Q+ +++ + ++ LQT L + N+ V
Sbjct: 2418 FENILQEKEQEKVQM---------------------KEKSSTAMEMLQTQLKELNERVAA 2456
Query: 597 LSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTRE 656
L Q+ ++ C L+ K ++LQ L +N ++ + + GL+Q V +
Sbjct: 2457 LHNDQEACKAKEQNLSSQVECLELE-KAQLLQGLDEAKNNYIV-LQSSVNGLIQEVEDGK 2514
Query: 657 QESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQG 716
Q+ L +++ E+ L+ + ++ L+S+ Q E G+
Sbjct: 2515 QK-----------LEKKDEEISRLKNQIQDQEQLVSKL----SQVE-------GEHQLWK 2552
Query: 717 SMQIPSRDDSTSLTAKEDVSIPRSTLGDL-DTVAGLEKELSNAKEELELMAKKERESQME 775
+ R+ + L K + + +S L DT+ L+ N + ELEL + +M
Sbjct: 2553 EQNLELRNLTVELEQK--IQVLQSKNASLQDTLEVLQSSYKNLENELEL----TKMDKMS 2606
Query: 776 LSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVL 835
+ M +E ELQ + +M T +Q E+L + RL E+
Sbjct: 2607 FVEKVNKMTAKETELQREMHEMAQKTAELQ--EELSGE-------------KNRLAGELQ 2651
Query: 836 LLREKVASVESQGQEI---SGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHA 892
LL E++ S + Q +E+ + ++ L M + V++ ++ E + AE QL +
Sbjct: 2652 LLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEI-AEYQLRLHEAEKKH 2710
Query: 893 HPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTE 952
+ ++ +VE++ + + EE L ++ L+ + + + S +
Sbjct: 2711 QALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLK---------SSKEELNNSLK 2761
Query: 953 FTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAE 1012
T I EE L V K N Q +M L
Sbjct: 2762 ATTQILEELKKTKMDNLKYVNQLKK--------------------ENERAQGKMKLLIKS 2801
Query: 1013 FHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWE 1072
Q EEK ++EL +L+A E+ +V + + L E ELKE + E + E
Sbjct: 2802 CKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTK--VDELTTEIKELKETLEEKTKEADE 2859
Query: 1073 I----------EEDKEKGEVMVETVV 1088
E EK + M+ET V
Sbjct: 2860 YLDKYCSLLISHEKLEKAKEMLETQV 2885
Score = 99.4 bits (246), Expect = 4e-20
Identities = 338/1739 (19%), Positives = 660/1739 (37%), Gaps = 257/1739 (14%)
Query: 3 NGYRTLSQHLNDLKKENFSLKLRIY---FLEERMQQKYEASREDIYKRNIELKVEV---- 55
N Y LSQ +++N L+ + L E + + E +E K + E ++
Sbjct: 1034 NAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAE 1093
Query: 56 ---ESLKRELQDKKQHLDKTWADVENLNSQNEA-----ELRRQFEERQQETEHVYELLEN 107
++L EL+ +Q L D +N NS++EA E+ EE+ + + V +LL+
Sbjct: 1094 ERNQNLMLELETVQQALRSEMTDNQN-NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQE 1152
Query: 108 KIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEA 167
QL++ + + + + KE SE+ + K D+ ++ D Y
Sbjct: 1153 NEQLMKVMKTKHECQNLESEPIRNSVKERE---SERNQCNFKPQMDLEVKEISLDSYNAQ 1209
Query: 168 LAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSH 227
L Q + + L E+ E L E Q + LE ++Q LK ++++
Sbjct: 1210 LVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAE 1269
Query: 228 ETTIT---QQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQES-----SQKQ 279
E I+ + S S + A LQ +Q T KLNE+ + Q ++
Sbjct: 1270 EKYISGPHELSTSQNDNAHLQCSLQTT-------MNKLNELEKICEILQAEKYELVTELN 1322
Query: 280 DGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSE-GTSPAQQQ 338
D + + T K E E +L ++ ND +LH + + E G P +Q
Sbjct: 1323 DSRSECITATRKMAE-EVGKLLNEVKILNDDSG----LLHGELVEDIPGGEFGEQPNEQH 1377
Query: 339 -VALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHN 397
V+L L + L + + V+ +L + +Q H+ Q +
Sbjct: 1378 PVSLAPLDESNSYEHLTLS--DKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMS-- 1433
Query: 398 QELRKALQQLQEELQNKSQQLRAWEAEKYNEIRT--QEQNIQHLNHSLSHKEQLLQEFRE 455
EL+ + L+ E S LR ++ + E++ +E + L+ S L +
Sbjct: 1434 -ELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGD 1492
Query: 456 LLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKF-SALEEKEKELRQLRLAVR 514
YR ++T + + L + A + ++DE F S+L+E+ ++ A
Sbjct: 1493 SSFYRALLEQTGDMS------LLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAP- 1545
Query: 515 ERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTC----QNLQWLKEEMETKFS 570
AKG VE+L + C Q+L+ L+E+ME++
Sbjct: 1546 ----------------------------AKG--VEELESLCEVYRQSLEKLEEKMESQGI 1575
Query: 571 RWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEI-----------------A 613
KE IQ+L+ L +E++ L L + Q ++
Sbjct: 1576 MKNKE----IQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQT 1631
Query: 614 EELCQRLQRKERMLQDL-LSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALME 672
E+L L+ LQ L LS R+ ++ E IQG +S ++ + E+ + +
Sbjct: 1632 EQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVH 1691
Query: 673 RNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTG-CLGKQTDQGSMQIPSRDDSTSLT- 730
+ + A + L + V PTG C G+Q+ + + P D + +
Sbjct: 1692 QICDKDA-------QQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSE 1744
Query: 731 -------AKEDVSIPRSTLGDLDTVAGLE---KELSNAK-EELELMAKKERESQM---EL 776
+ + +P LG+ + + L+ KE SN L ++ ++R+ + E+
Sbjct: 1745 CISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEM 1804
Query: 777 SALQSMMAVQEEELQVQ---AADMESLTRNIQIK-EDLIKDLQMQLVDPEDIPAMERL-T 831
L S + +QE +L + ++E + ++ + DL + L+ D +++ ++R+ T
Sbjct: 1805 KELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQEL--LQRVET 1862
Query: 832 QEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFH 891
E L ++ + +S ++I N + E +D + L+ + + +
Sbjct: 1863 SEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLE 1922
Query: 892 AHPESSERDR-TLQVELEGAQVLRSRLEEVLGRSLERLNRL--ETLAAIGGAAAGDDTED 948
A E + ++ L+ + E Q + LEE L N+L E A D +
Sbjct: 1923 ADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSE 1982
Query: 949 TSTEFTDSIEEEAAHHSH-QQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEML 1007
E T +E + H Q+ + +++ ++T + S E+L
Sbjct: 1983 KMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVS---------------ELL 2027
Query: 1008 HLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAM 1067
+ + L+ K + L K ++E + ++ + L E+ L+ ++ E
Sbjct: 2028 KDKTHLQEKLQSLEKDSQALSLTKCELE----NQIAQLNKEKELLVKESESLQARLSE-- 2081
Query: 1068 SDGWEIEEDK-------EKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLK 1120
SD ++ K EKGE + T+E + + L+ KL+ +++ +
Sbjct: 2082 SDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQ--LRRGIEKLRVRIEADEKKQLHIA 2139
Query: 1121 EQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLD 1180
E+L +E +S L +E + EL Q EE V +
Sbjct: 2140 EKLKERERENDS---------LKDKVENLEREL-------QMSEENQELVILDAENSKAE 2183
Query: 1181 LGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEAT 1240
+ T Q++ ++ +L ++L Q+ + + + +L +KLL S +
Sbjct: 2184 VETLKT----QIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSEL-DKLLSSFKS 2238
Query: 1241 VFAQANELEKYRVMLTGESLVKQDSKQIQV-DLQDLGYETCGRSENEAEREETTSPECEE 1299
+ E E+ + + ES + Q Q+ +L + CG E E++ P EE
Sbjct: 2239 LL---EEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEE 2295
Query: 1300 HNSLKEMV-----------------------------LMEGLCSEQGRRGSTLASSSERK 1330
+ L+ + L++G R ++ E
Sbjct: 2296 EHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHA 2355
Query: 1331 PLENQLGKQE----EFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLS-VT 1385
LE + K E + ++ G ++++ L D+ ++++ +N +Q + R+ L +
Sbjct: 2356 ALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIIN 2415
Query: 1386 SDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRV 1445
S + + L+ + + + S+ + L++ A ++ K ++L +V
Sbjct: 2416 SSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQV 2475
Query: 1446 SQLEAQLPK--NGLEEKLAEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLIT 1503
LE + + GL+E + S + LIQ+ L +K E I+
Sbjct: 2476 ECLELEKAQLLQGLDEAKNNYIVLQS---SVNGLIQEVEDGKQKLEKKDEE-------IS 2525
Query: 1504 RHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLE 1563
R K+ ++ E L+ Q ++EQ + LT L K+ K+ Q LE
Sbjct: 2526 R-LKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLE 2584
Query: 1564 PLA-----LRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDEL 1617
L L EL + +K+ V + +T + + H T+ L +EL
Sbjct: 2585 VLQSSYKNLENELELTKMDKMSFVEK----VNKMTAKETELQREMHEMAQKTAELQEEL 2639
Score = 99.4 bits (246), Expect = 4e-20
Identities = 268/1251 (21%), Positives = 488/1251 (39%), Gaps = 181/1251 (14%)
Query: 75 DVENLN------SQNEAELRRQFEERQQETEHVY---ELLENKIQLLQEESRLAKNEAA- 124
D+ NL S L E+R ++ E + + L++K+ L QE + K EA
Sbjct: 1768 DIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHL-QEVQLMTKIEACI 1826
Query: 125 RMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAA 184
+ +V K+ N +LSEKL+ + + ++ L QR + E LN L
Sbjct: 1827 ELEKIVGELKKENSDLSEKLEYFSCDHQE--------------LLQRVETSEGLNSDL-- 1870
Query: 185 QERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAEL 244
E ++ SRE + + + E L + + + I + S H A
Sbjct: 1871 -EMHADKSSRED------IGDNVAKVNDSWKERFLD---VENELSRIRSEKASIEHEALY 1920
Query: 245 QEKIQQTEATNKILQEKLNEMSYE-LKCAQESSQKQDGTIQNLKETLKSRERETEELYQV 303
E + T K+ EK NE + + C +E L+ L + ++T L Q+
Sbjct: 1921 LEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQL 1980
Query: 304 IEGQNDTMAKLR----EMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQ-KL 358
E + +L E LH Q+ + E T Q L S L + +Q KL
Sbjct: 1981 SEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQ---TLSSDVSELLKDKTHLQEKL 2037
Query: 359 QRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL 418
Q + +K+ Q +C +E + ++KE K ++ L+ L + E N S+ L
Sbjct: 2038 QSL--EKDSQALSLTKCE--LENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKAL 2093
Query: 419 RAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLR 478
A EK E + + Q H L + L+ ++ + K L E L E+ R
Sbjct: 2094 EAALVEK-GEFALRLSSTQEEVHQLRRGIEKLR-----VRIEADEKKQLHIAEKLKERER 2147
Query: 479 QR--IHDKAVALERAID--EKFSAL-----EEKEKELRQLRLAVRERDHDLERLRDVLSS 529
+ + DK LER + E+ L E + E+ L+ + E L+ L +
Sbjct: 2148 ENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVT 2207
Query: 530 NEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHD 589
+ +++ ++ K ++ +L + + L EE E + ++E ++ ++ LQ L +
Sbjct: 2208 LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKE 2267
Query: 590 RNKEVEDLSATLLCKLGPGQSEIAEELCQRLQ---RKERMLQDLLSDRNKQVLEHEMEIQ 646
N+ V LC G EI + Q L +E L++ + ++ E +
Sbjct: 2268 LNEAV-----AALC----GDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQL 2318
Query: 647 GLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVT-- 704
+LQ + +E E A K +ER E+ Q ++ S+ + +A++
Sbjct: 2319 CVLQQL--KESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGM 2376
Query: 705 PTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELEL 764
G + D + R + +LT ++ + + +L+ + + + KE+ ++
Sbjct: 2377 TQSLRGLELDV----VTIRSEKENLT--NELQKEQERISELEIINSSFENILQEKEQEKV 2430
Query: 765 MAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDI 824
K++ + ME M+ Q +EL + A + + + KE + Q++ ++ E
Sbjct: 2431 QMKEKSSTAME------MLQTQLKELNERVAALHNDQEACKAKEQNLSS-QVECLELEKA 2483
Query: 825 PAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLY 884
++ L + +SV QE+ +++ LE +E SRL +Q + QL
Sbjct: 2484 QLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQK-----LEKKDEEISRLKNQIQDQEQLV 2538
Query: 885 SSLVKFHAH----PESSERDRTLQVELEGA-QVLRSRLE------EVLGRSLERL-NRLE 932
S L + E + R L VELE QVL+S+ EVL S + L N LE
Sbjct: 2539 SKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELE 2598
Query: 933 TLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPS 992
T+ F + + + A + +L + E + T E Q
Sbjct: 2599 L------------TKMDKMSFVEKVNKMTAKET--ELQREMHEMAQKTAELQEE------ 2638
Query: 993 PMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSL 1052
+ G+ NR L E LEE + ++++LKE L
Sbjct: 2639 -LSGEKNR--------LAGELQLLLEEIKSSKDQLKE----------------------L 2667
Query: 1053 CLENAELKEQMGEAMSDGWEIEEDKEKGEV------MVETVVTKEGL---SESSLQAEFR 1103
LEN+ELK+ + D E +E K + E+ + E + L + + E +
Sbjct: 2668 TLENSELKKSLDCMHKDQVE-KEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQ 2726
Query: 1104 KLQGKLKNAHNIIN--LLKEQLVLSSKE---GNSKLTPELLVHLTSTIERINTELVGSPG 1158
+ KL + ++ L+ L+ SSKE + K T ++L L T + N + V
Sbjct: 2727 TYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKT-KMDNLKYVNQLK 2785
Query: 1159 KHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRS 1218
K + +G + + Q + + QL + + G + T ++
Sbjct: 2786 KENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKE 2845
Query: 1219 QLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGE--SLVKQDSKQ 1267
+++ ++ E L ++ +LEK + ML + L Q SKQ
Sbjct: 2846 LKETLEEKTKEADE-YLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQ 2895
Score = 92.8 bits (229), Expect = 4e-18
Identities = 325/1637 (19%), Positives = 622/1637 (37%), Gaps = 274/1637 (16%)
Query: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE 305
+KIQ+ E L+++ + ++L + + QKQ ++N K + +RE + L ++ E
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
Query: 306 GQNDTMAKLREMLHQSQLGQLHSSEG-TSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQ 364
T K+ L Q + Q++ EG + ++Q+ L+ Q C E+++ Q+ +
Sbjct: 78 SLEKTKQKISHEL-QVKESQVNFQEGQLNSGKKQIEKLE-QELKRCKS-ELERSQQAAQS 134
Query: 365 KERQLADAKQ-----CVQFVEAAAHESEQQKEASWKHNQEL---------------RKAL 404
+ L + + + ++ K+N+E+ +KA
Sbjct: 135 ADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKAS 194
Query: 405 QQLQEELQN--------KSQQLRAWEAEKY-NEIRTQEQNI---QHLNHSLSHKEQLLQE 452
Q L + N S + +W+ EK + + + Q + + S EQ +
Sbjct: 195 QTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTP 254
Query: 453 FRELLQ---------YRDNSDK--TLEANEMLLEKLRQRIHDKAVAL---ERAIDEKFSA 498
R LQ + DNS L+ + ++LR +I++ + L E+ + + +
Sbjct: 255 SRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNK 314
Query: 499 LEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLE------VEQLS 552
+E + +L + ++ + E++ L + RD L T Q ++ + LE E LS
Sbjct: 315 FQELQLQLEKAKVELIEKEKVLNKCRDELV--RTTAQYDQASTKYTALEQKLKKLTEDLS 372
Query: 553 TTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPG---- 608
QN + + +E K +KE + + + Q S ++E + A L +L
Sbjct: 373 CQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMH 432
Query: 609 ---QSEI-------------AEELCQRLQRKERMLQ--------------------DLLS 632
Q+E+ EE Q+L R E+ Q +LL
Sbjct: 433 NVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLK 492
Query: 633 DRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMS 692
++Q ++ L+++ +SQ AE++ + + L+ L++ + +++ ++
Sbjct: 493 SHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLT 552
Query: 693 QAPISNQQAEV-TPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL 751
+ A++ C + I +D S T KE ++ L +
Sbjct: 553 LEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKAL-------LSALELK 605
Query: 752 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIK---- 807
+KE KEE L + + E++ L+ ++S ++E LQ + +E+ + QIK
Sbjct: 606 KKEYEELKEEKTLFSCWKSENEKLLTQMES----EKENLQSKINHLETCLKTQQIKSHEY 661
Query: 808 EDLIKDLQMQLVDPEDIPAMERLTQEVL------LLREKVASVE-SQGQEISGNRRQQLL 860
+ ++ L+M D E++ R VL + +K+A +E Q E S + Q+
Sbjct: 662 NERVRTLEM---DRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK-- 716
Query: 861 LMLEGLVDERSRLN---EALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRL 917
+E + + S+L E L+ + QL S+ E ++DR Q L +
Sbjct: 717 -EIENMCLKTSQLTGQVEDLEHKLQLLSN--------EIMDKDRCY-------QDLHAEY 760
Query: 918 EEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLV----KVA 973
E SL L + + + + ED ++ A HHS ++ +
Sbjct: 761 E-----SLRDLLKSKDASLV-------TNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMP 808
Query: 974 LEKSLATVET-QNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKA 1032
E+S +E Q+P S DS E + ++ + EE + + E++E
Sbjct: 809 SERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLM 868
Query: 1033 QIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEG 1092
+ E+ S V+ + L + + + + E +S E+KEK ++ V E
Sbjct: 869 KAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLS----ALENKEKELQLLNDKVETEQ 924
Query: 1093 LSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNS-----KLTPELLVHLTSTIE 1147
L+ L+ LK + LL E L L KE +S K E L T++
Sbjct: 925 AEIQELKKSNHLLEDSLKE----LQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLK 980
Query: 1148 RINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAF 1207
IN L +QE+ N+ + +D + + S+ D Q
Sbjct: 981 EINASL--------NQEKMNLIQKSESFANYID---------EREKSISELSDQYKQEKL 1023
Query: 1208 SLPGSTQHLRSQLSQCKQRYQDLQEK-----LLLSEATVFAQ--ANELE--------KYR 1252
L + + Q+Y+ QEK LL+E T + NELE +++
Sbjct: 1024 ILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQ 1083
Query: 1253 VMLTGESLVKQDSKQIQVDLQDL---------GYETCGRSENEAEREETTSPECEEHNSL 1303
LT + ++ ++ + ++L+ + + +SE ++E + + E++
Sbjct: 1084 EFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQ 1143
Query: 1304 KEM--VLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDL 1361
KE+ +L E + + + E +P+ N + ++E R + + L ++K++
Sbjct: 1144 KEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDL--EVKEI 1201
Query: 1362 KAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAV-GTLEGSSPHSVPDEDEGWL 1420
NA V R + L + +L+ + G LE S+ + ++ L
Sbjct: 1202 SLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGL 1261
Query: 1421 S----DGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDS 1476
D + S + L+ + K EK+ E L++ KY+
Sbjct: 1262 KDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAE----KYE- 1316
Query: 1477 LIQDQARELSYLRQKIREGRGICYLITRH-AKDTVKSFEDLLRSNDIDYYLGQSFREQLA 1535
L ++ + R C TR A++ K ++ ND L E +
Sbjct: 1317 -----------LVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIP 1365
Query: 1536 QGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRE-LQEKEKVIEVLQAKLDARSLTP 1594
G + +E+ L PL S E L +K +++ A+L + L+
Sbjct: 1366 GG-----------EFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSL 1414
Query: 1595 SSSH-ALSDSHRSPSS---------TSFLSDELEACSDM-----DIVSEYTHYEEKKASP 1639
S H L D H SS S ++ L +++ D+V E E+ P
Sbjct: 1415 QSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVP 1474
Query: 1640 SHSDSIHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHS 1699
S S S S SS S +S + +SL + ANQ F S
Sbjct: 1475 SLSSSCVPDS-----SSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCS 1529
Query: 1700 IPKLASLPQAPLPSAPS 1716
+ +L + PSAP+
Sbjct: 1530 SLQEENLTRKETPSAPA 1546
Score = 56.2 bits (134), Expect = 4e-07
Identities = 244/1347 (18%), Positives = 499/1347 (37%), Gaps = 194/1347 (14%)
Query: 855 RRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLR 914
R Q + LEG +D+ + E Q + QL S + E ++T L+
Sbjct: 15 RALQKIQELEGQLDKLKK--EKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRL 72
Query: 915 SRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVAL 974
+ E L ++ ++++ E + ++ + + +E+E K L
Sbjct: 73 MEICESLEKTKQKISH-ELQVKESQVNFQEGQLNSGKKQIEKLEQELKR------CKSEL 125
Query: 975 EKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQI 1034
E+S ++ + S +P + L + +++ E+ K EE K L+A++
Sbjct: 126 ERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEV 185
Query: 1035 EEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLS 1094
+ S T+ + + ++ + W+ E+ T LS
Sbjct: 186 KALQAKKASQ---TLPQATMNHRDIARHQASSSVFSWQQEK-------------TPSHLS 229
Query: 1095 ESSLQAEFRK-LQGKLKNAHNIINLLKEQLVLSSKEGNSKL-----TPELLVHLTSTIER 1148
+S + R+ + + + L + ++ NS +P LL L + +
Sbjct: 230 SNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQE 289
Query: 1149 INTELVGSPGKHQ-HQEEGNVTVRPFPRPQ-SLDLGATFTVDAHQLDNQSQPRDPGPQSA 1206
+ ++ + Q H++E V F Q L+ ++ ++ N+ +
Sbjct: 290 LRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDE------- 342
Query: 1207 FSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSK 1266
+Q Q +Y L++KL + Q E R L E +K+ K
Sbjct: 343 ------LVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSL--EQKIKEKEK 394
Query: 1267 QIQVDL--QDLGYETCGR---------------SEN-----EAEREETTSPECEEHNSLK 1304
+ Q +L Q ++T + ++N +AE ++ TS + + N+L+
Sbjct: 395 EFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLE 454
Query: 1305 EMVLMEGLC-SEQGRRGSTLASSSERKPLENQLGKQEEFRVYG--KSENILVLRKDIKDL 1361
E + LC +EQ + S + + R+ +E + + + K+ + L ++K++
Sbjct: 455 EF--KQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNI 512
Query: 1362 KAQLQNANKVIQNLKSRVRSL-SVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWL 1420
K L + + +K++ S ++ D + + + L+ + D
Sbjct: 513 KQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRD---- 568
Query: 1421 SDGTGAFYSPGLQAKKD--LESLIQRVSQLEAQ---------LPKNGLEEKLAEELRSAS 1469
S L K++ +E L ++S+ E + L K EE E+ +
Sbjct: 569 -------CSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSC 621
Query: 1470 WPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFE--DLLRSNDIDYYLG 1527
W + + L+ E L+ KI +L T +KS E + +R+ ++D
Sbjct: 622 WKSENEKLLTQMESEKENLQSKIN------HLETCLKTQQIKSHEYNERVRTLEMD---- 671
Query: 1528 QSFREQLAQ---------GSQLTERLTSKLS------TKDHKSEKDQAGLEPLALR---- 1568
RE L+ S+ E T KL+ + +K Q +E + L+
Sbjct: 672 ---RENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQL 728
Query: 1569 -------------LSRELQEKEKVIEVLQAKLDA-RSLTPSSSHAL-SDSHRSPSSTSFL 1613
LS E+ +K++ + L A+ ++ R L S +L ++ S +F
Sbjct: 729 TGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFD 788
Query: 1614 SDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAESNS 1673
S +I+ E ++ S ++ +SA+L ++ S S ++ + NS
Sbjct: 789 QQPAMHHSFANIIGEQGSMPSER-SECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNS 847
Query: 1674 N---------PISLPTPQNTPKEANQAHSGFHFHSIPKLASLP------QAPLPSAPSSF 1718
+ I +N K A Q H F + +++ L Q + S+
Sbjct: 848 DLQKQCEELVQIKGEIEENLMK-AEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSAL 906
Query: 1719 LPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGESASTVPPASTATLLSNDLEADSS 1778
LL ET + E ++ +L+ L E + TL E S
Sbjct: 907 ENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLL-----SETLSLEKKEMSSI 961
Query: 1779 YYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQLNSKP 1838
LN + T E G + E + K ++++ + + S+ +L+ +
Sbjct: 962 ISLNKREIEEL---TQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQY 1018
Query: 1839 TGADLL-----EEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSN----- 1888
L+ EE +L Q+ + + N +L E L + TS R +
Sbjct: 1019 KQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKL-ECLLNECTSLCENRKNELEQLKEA 1077
Query: 1889 FYSQGLESIPQLC-----NENRVLREDN--RRLQAQLSHVSREHSQETESLREALLSSRS 1941
F + E + +L N+N +L + + L+++++ E L++ +++ +
Sbjct: 1078 FAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKE 1137
Query: 1942 HLQELEKELEHQKVERQQLLEDLREKQQ-EVLHFREERLSLQENDSRLQHKLVLLQQQCE 2000
+++KE+ E +QL++ ++ K + + L R S++E +S Q E
Sbjct: 1138 EQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLE 1197
Query: 2001 EKQQLFESLQSELQIYEALYGNSKKGLKAYSLD-ACHQIPLSSDLSHLVAEVRALRGQLE 2059
K+ +S ++L EA+ N + L+ + C Q L + L E L+
Sbjct: 1198 VKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDL--ETSNLQDMQS 1255
Query: 2060 QSIQGNNCLRLQLQQQLESGAGKASLS 2086
Q I G + +++ SG + S S
Sbjct: 1256 QEISGLKDCEIDAEEKYISGPHELSTS 1282
Score = 43.9 bits (102), Expect = 0.002
Identities = 61/252 (24%), Positives = 112/252 (44%), Gaps = 33/252 (13%)
Query: 1845 EEHL--GEIRNLRQRLE----ESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIP 1898
EEH I LR RLE + +C+ +L+E H +GR + LE I
Sbjct: 2295 EEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHH--ADLLKGRVEN---LERELE-IA 2348
Query: 1899 QLCNENRVLREDNRRLQAQLSHVSREH-SQETESLREALLSSRSHLQELEKEL--EHQKV 1955
+ E+ L +N + + + E +Q L +++ RS + L EL E +++
Sbjct: 2349 RTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERI 2408
Query: 1956 ERQQLLED-----LREKQQEVLHFREERLS----LQENDSRLQHKLVLL---QQQCEEKQ 2003
+++ L+EK+QE + +E+ + LQ L ++ L Q+ C+ K+
Sbjct: 2409 SELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKE 2468
Query: 2004 QLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQ 2063
Q +L S+++ E +GL + I L S ++ L+ EV + +LE+ +
Sbjct: 2469 Q---NLSSQVECLELEKAQLLQGLDEAK---NNYIVLQSSVNGLIQEVEDGKQKLEKKDE 2522
Query: 2064 GNNCLRLQLQQQ 2075
+ L+ Q+Q Q
Sbjct: 2523 EISRLKNQIQDQ 2534
Score = 43.9 bits (102), Expect = 0.002
Identities = 61/286 (21%), Positives = 127/286 (44%), Gaps = 38/286 (13%)
Query: 1845 EEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNEN 1904
+E + E+ + E + ++ + Q++ + +STA T + E + L N+
Sbjct: 2405 QERISELEIINSSFENILQEKEQEKVQMKEK-SSTAMEMLQTQ--LKELNERVAALHNDQ 2461
Query: 1905 RVLREDNRRLQAQLSHVSREHSQETESLREA------LLSSRSHL--------QELEKE- 1949
+ + L +Q+ + E +Q + L EA L SS + L Q+LEK+
Sbjct: 2462 EACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKD 2521
Query: 1950 -----LEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQ 2004
L++Q +++QL+ L + + E ++E+ L L+ L+ K+ +LQ +
Sbjct: 2522 EEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNA---- 2577
Query: 2005 LFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQG 2064
SLQ L++ ++ Y N + L+ +D ++ ++ + A+ L+ ++ + Q
Sbjct: 2578 ---SLQDTLEVLQSSYKNLENELELTKMD---KMSFVEKVNKMTAKETELQREMHEMAQK 2631
Query: 2065 NNCLRLQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDS 2110
L+ +L + AG+ L I S+ K+L L++S
Sbjct: 2632 TAELQEELSGEKNRLAGELQLLLEEIK-----SSKDQLKELTLENS 2672
Score = 42.4 bits (98), Expect = 0.005
Identities = 64/267 (23%), Positives = 122/267 (45%), Gaps = 48/267 (17%)
Query: 1833 QLNSKPTGADLLEEHLGEIR----NLRQRLEESICINDRLREQLEHRLTSTARGRGSTSN 1888
QL +K LE+ +GE++ +L ++LE C + L +++E
Sbjct: 1817 QLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVET-------------- 1862
Query: 1889 FYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQE--- 1945
S+GL S ++ + ++ RED A+++ +E + E+ + S ++ ++
Sbjct: 1863 --SEGLNSDLEM-HADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEAL 1919
Query: 1946 -LEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQEND-----------SRLQHKLV 1993
LE +LE + E+ L +D E +Q+V+ EE LS+ ++ S+ L
Sbjct: 1920 YLEADLEVVQTEKLCLEKD-NENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALD 1978
Query: 1994 LLQQQCEEKQQLFESLQSE----LQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVA 2049
L ++ +EK Q ES QSE +Q+ EA + L+ S D L D +HL
Sbjct: 1979 QLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSE---LLKDKTHLQE 2035
Query: 2050 EVRALRGQLEQSIQGNNCLRLQLQQQL 2076
++++ LE+ Q + + +L+ Q+
Sbjct: 2036 KLQS----LEKDSQALSLTKCELENQI 2058
Score = 31.6 bits (70), Expect = 9.6
Identities = 52/238 (21%), Positives = 94/238 (39%), Gaps = 26/238 (10%)
Query: 1869 REQLEHRLTSTARGRGSTSNFY--SQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHS 1926
+E R T R + S+F+ S + QL +N+ LR L+ +L +E
Sbjct: 250 QEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMK 309
Query: 1927 QETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDS 1986
+ QEL+ +LE KVE + + L + + E++ + +
Sbjct: 310 GQVNKF-----------QELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYT 358
Query: 1987 RLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSH 2046
L+ KL L + ++Q ES + L+ K+ K + + Q L
Sbjct: 359 ALEQKLKKLTEDLSCQRQNAESARCSLE------QKIKEKEKEFQEELSRQQRSFQTLDQ 412
Query: 2047 LVAEVRA-LRGQLEQSIQGNNCLRLQL------QQQLESGAGKASLSPSSINQNFPAS 2097
+++A L +L+Q+ +N L+ +L +QQLE+ + Q F AS
Sbjct: 413 ECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQAS 470
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 157 bits (396), Expect = 2e-37
Identities = 484/2182 (22%), Positives = 846/2182 (38%), Gaps = 388/2182 (17%)
Query: 17 KENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADV 76
+E L L + +E ++ +E S+E I+LK + + K ELQD+ L A +
Sbjct: 241 REPAQLLLLLAKTQELEKEAHERSQE-----LIQLKSQGDLEKAELQDRVTELS---ALL 292
Query: 77 ENLNSQNEAELRRQFEERQQETEHVYELLE-NKIQLLQEESRLAKNEAARMAALVEAEKE 135
QNE +E+ + E+LE N +L++ E+ L++N +L + K+
Sbjct: 293 TQSQKQNE-----DYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKD 347
Query: 136 CNLELSEKLKGVT-----KNWEDVPGDQVKPDQYTEA----------LAQRDKRIEELNQ 180
+ E+ + +N ++ Y +A L +R + +++L Q
Sbjct: 348 ITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQ 407
Query: 181 SLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSH 240
LA + V L ++ Q EE E + + + L QKL T+ Q+V
Sbjct: 408 QLAGCQEAVNLLQQQHDQ----WEE----EGKALRQRL---QKLTGERDTLAGQTV---- 452
Query: 241 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESS----------QKQDGTIQNLKE-- 288
+LQ ++ ++LQ+ E+ +L+ ++ + Q Q + Q KE
Sbjct: 453 --DLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQ 510
Query: 289 ------TLKSRERETEELYQVIEGQNDTMAK---LREMLHQSQLGQLHSSEGTSPAQQQV 339
++ RER E L + Q++++++ LRE L S L EG Q+Q
Sbjct: 511 QEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHL------EGELLRQEQT 564
Query: 340 ALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQE 399
++ +AL ++ I +L + ++AD + AAA + EA
Sbjct: 565 ---EVTAALARAEQSIAELSSSENTLKTEVAD-------LRAAAVKLSALNEALALDKVG 614
Query: 400 LRKALQQLQEELQNKSQQLRA------------WEAEKYNEIRTQEQNIQHLNHSLSHKE 447
L + L QL+EE Q+ ++ A EAEK E ++ HL L E
Sbjct: 615 LNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNT--HLEAQLQKAE 672
Query: 448 ----QLLQEFRELLQYRDNSDKTL-------EANEMLLEKLRQRIHDKAVALERAIDEKF 496
+L + R++ + ++ K L EA LE+L Q + L RA+ EK
Sbjct: 673 EAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKE 732
Query: 497 SALEEKEKELRQLRLAVRERDHD--------LERLRDVLSSNEATMQSMESLLR-AKGLE 547
+ + +EK ++RL ERD L +++L S+ Q S++ KG
Sbjct: 733 ALV--REKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQL 790
Query: 548 VEQLSTTCQ-------NLQWLKEEMETKFSRWQKEQESIIQQL-------QTSLHDR--- 590
Q+ T Q ++ LK E++T+ S+ ++E+++ +QL +T+L +
Sbjct: 791 EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAA 850
Query: 591 -NKEVEDLSATLLCKLGPGQSEIAE----------ELCQRLQRKERMLQDLLSDRNKQ-- 637
KEV L + Q E+A+ EL RL+ ++ ++ + + R ++
Sbjct: 851 HEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERT 910
Query: 638 ---------VLEHEMEIQGLLQSVSTREQESQAAAEKL--------VQALMER------N 674
LE E E LL+++ ++E A+++L VQ L E+
Sbjct: 911 QAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQ 970
Query: 675 SELQALRQYL--GGRDSLMSQAPISNQQAEVTPTGC-LGKQTDQGSMQIPSRDDSTSLTA 731
++LQ ++ L R A + + + + L KQ + Q+ ++DDS L
Sbjct: 971 TQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVE 1030
Query: 732 KEDVSIPRSTLGDLDTVAGLEKE-----LSNAKEELELMAKKERES--QMELSALQSMMA 784
+E R T LE+E LS ++E L+ +E +S Q ELSAL+ M
Sbjct: 1031 QEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQ 1090
Query: 785 VQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASV 844
+ E + +A ME L + ++ KE + QL+ E++ A Q+ LR + +
Sbjct: 1091 EAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLL--EELEASHITEQQ---LRASLWAQ 1145
Query: 845 ESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQ---LYSSLVK-----FHAHPES 896
E++ ++ R + LE L E+ N+A QA+ Q LYS+L + + PE
Sbjct: 1146 EAKAAQLQ-LRLRSTESQLEALAAEQQPGNQA-QAQAQLASLYSALQQALGSVCESRPEL 1203
Query: 897 SERDRT------LQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTS 950
S + L+ + GA+ L R + S E A+ A +
Sbjct: 1204 SGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAE---------AVASALHKLHQDLWK 1254
Query: 951 TEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLR 1010
T+ T + + ++L EKS E Q+ L+
Sbjct: 1255 TQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQD-----------------------LQ 1291
Query: 1011 AEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDG 1070
+ Q+ EEK K E + L++++ E + TM SL + Q EA +
Sbjct: 1292 RQLSQNQEEKSKWEGKQNSLESELME--------LHETMASLQSRLRRAELQRMEAQGER 1343
Query: 1071 WEIEEDKEKGEVMVE--TVVTKEGLSESS----LQAEFRKLQGKLKNAHNIINLLKEQLV 1124
++ KE VE E +++S L+ + R + LK + + +E+
Sbjct: 1344 ELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQ 1403
Query: 1125 LSSKEGNSKLT-----PELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSL 1179
++G K+ E L LT T+ E+ G+ Q E+ + SL
Sbjct: 1404 ALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSL 1463
Query: 1180 DL-GATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSE 1238
DL VD Q Q Q + LP + Q +L+ +++ ++L++
Sbjct: 1464 DLKKRNQEVDLQQ--EQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQR 1521
Query: 1239 ATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECE 1298
+ Q ELEK M+ + QD K+ V L+ L E + ++ E ++ E E
Sbjct: 1522 NVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALE-LEENHHKMECQQKLIKELE 1580
Query: 1299 EHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLG------KQEEFRVYGKSENIL 1352
+ + L + R A SS+ LE+ ++ + V + E I
Sbjct: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIE 1640
Query: 1353 VLRKDIKDLKAQLQNANKVIQNLKSRVRSLS-----VTSDYSSSLER-PWKLRAVG---T 1403
L++ + L L+ ++ + K R++ L T LE+ LR G T
Sbjct: 1641 ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELT 1700
Query: 1404 LEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAK-KDLESLIQRVSQLEAQLPKNGLEEKLA 1462
+ +E +G G+ L + K+ E Q+ E Q K+ LE++L
Sbjct: 1701 TQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQ 1760
Query: 1463 EELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDI 1522
R G+ L+ + +E+ L+Q+++E R + L+ +
Sbjct: 1761 GLHRKV---GETSLLLSQREQEIVVLQQQLQEARE----------------QGELKEQSL 1801
Query: 1523 DYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEV 1582
L ++ R LAQ Q E L + E+ QA +E + KEK +
Sbjct: 1802 QSQLDEAQR-ALAQRDQELEAL---------QQEQQQA--------QGQEERVKEKA-DA 1842
Query: 1583 LQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHS 1642
LQ L+ +T H H+ + L +EL + E+ +
Sbjct: 1843 LQGALEQAHMTLKERHGELQDHKEQARR--LEEELA------VEGRRVQALEEVLGDLRA 1894
Query: 1643 DSIHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPK 1702
+S A+L+ + +Q + E+ + S Q KE +Q S
Sbjct: 1895 ES--REQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAES--- 1949
Query: 1703 LASLPQAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGESA--STV 1760
+S Q A + L +L +A LQ ++ L E A S
Sbjct: 1950 QSSRHQEEAARARAEALQ----------------EALGKAHAALQGKEQHLLEQAELSRS 1993
Query: 1761 PPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGS 1820
ASTATL ++ L++ Q HS R LE + +R Q+G
Sbjct: 1994 LEASTATLQAS---------LDACQAHS---------RQLE----------EALRIQEGE 2025
Query: 1821 VSG-DLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQL--EHRLT 1877
+ DL V QL D E L + Q LE+S+ R++E + E +
Sbjct: 2026 IQDQDLRYQEDVQQLQQALAQRD---EELRHQQEREQLLEKSLA--QRVQENMIQEKQNL 2080
Query: 1878 STARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALL 1937
R + E L + + + E R Q + + + HS +T + E L
Sbjct: 2081 GQEREEEEIRGLHQSVRELQLTLAQKEQEILE-LRETQQRNNLEALPHSHKTSPMEEQSL 2139
Query: 1938 SSRSHLQELEKELEH-QKVERQQLLEDL--REKQQEV-LHFREERLSLQENDSRLQHKLV 1993
S L++ELE Q RQ ++ REK Q++ L + + S+ S LQ +
Sbjct: 2140 KLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASV----SSLQEVAM 2195
Query: 1994 LLQQQCEEKQQLFESLQSELQI 2015
LQ E+ + LQ EL++
Sbjct: 2196 FLQASVLERDSEQQRLQDELEL 2217
Score = 147 bits (372), Expect = 9e-35
Identities = 469/2265 (20%), Positives = 873/2265 (38%), Gaps = 418/2265 (18%)
Query: 7 TLSQHLNDLKKENFSLKL--RIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQD 64
T S LN++K ++ L L ++ L+++M + AS + K + E + +L R+LQ
Sbjct: 3 TRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKL-KNSQEAQQRQATLVRKLQA 61
Query: 65 K-----------KQHLDKTWADV----ENLNSQNEAELRRQFEERQQETEHVYEL----- 104
K ++ L+ T + EN+ N EL + EE QQ E + E+
Sbjct: 62 KVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLR 121
Query: 105 -------LENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKN------- 150
+ NK L ++ +L + + L+ E + +E E KG K
Sbjct: 122 LHMEKADVVNKA-LREDVEKLTVDWSRARDELMRKESQWQME-QEFFKGYLKGEHGRLLS 179
Query: 151 -WEDVPGDQVKPDQYTEALAQRDKRIEELNQ----------------SLAAQERLVEQLS 193
W +V + + E + D+ + EL ++ AQ R
Sbjct: 180 LWREVVTFR---RHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSG 236
Query: 194 R----EKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQ 249
R E QLL LL + T+EL K+ S E I +S D AELQ+++
Sbjct: 237 RMDGREPAQLLLLLAK---------TQELEKEAHERSQEL-IQLKSQGDLEKAELQDRVT 286
Query: 250 QTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEE----LYQVIE 305
+ A Q++ + +K +E+ + + L E S R +E L QVI+
Sbjct: 287 ELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIK 346
Query: 306 GQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQK 365
M + + + Q G +S E S Q D AL + + + ++ V+
Sbjct: 347 DITQVMVEEGDNIAQGS-GHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDL 405
Query: 366 ERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEK 425
+QLA ++ V + QQ+ W +E KAL+Q ++L + L +
Sbjct: 406 RQQLAGCQEAVNLL--------QQQHDQW---EEEGKALRQRLQKLTGERDTLAGQTVDL 454
Query: 426 YNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA 485
E+ SLS + +LLQ+ RE L+ + LE +LE+ R+
Sbjct: 455 QGEV-----------DSLSKERELLQKAREELRQQ------LE----VLEQEAWRLRRVN 493
Query: 486 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATM-QSMESLLRAK 544
V L+ D SA +KE++ +L LAVRER ERL+++L EA +S+ L+ +
Sbjct: 494 VELQLQGD---SAQGQKEEQQEELHLAVRER----ERLQEMLMGLEAKQSESLSELITLR 546
Query: 545 GLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCK 604
E L ++ + L++E +T+ + E I +L +S + EV DL A + K
Sbjct: 547 ----EALESSHLEGELLRQE-QTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAV-K 600
Query: 605 LGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAA-- 662
L +A + N+Q+L+ E E Q + + EQ A
Sbjct: 601 LSALNEALALDKV---------------GLNQQLLQLEEENQSVCSRMEAAEQARNALQV 645
Query: 663 ----AEKLVQALMERNSELQA---------------LRQYLGGRDSLMSQAPISNQQAEV 703
AEK +AL E+N+ L+A LR ++ + + S Q E
Sbjct: 646 DLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEA 705
Query: 704 TPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELE 763
T Q +Q + +++ + +E ++ R + +E++ + E+L+
Sbjct: 706 ATT-----QLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQ 760
Query: 764 -LMAKKE--RESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVD 820
L + KE S E S++ V + +L+VQ ++++T+ ++ + ++ L+++L
Sbjct: 761 GLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQ---IQTVTQAKEVIQGEVRCLKLELDT 817
Query: 821 PEDIPAMER-----------------LTQEVLLLREKVASVESQGQEISGNRRQQLLLML 863
ER L Q+ ++V + + ++ +Q+L L
Sbjct: 818 ERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKAL 877
Query: 864 EGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTL-QVELEGAQVLRSRLEEVLG 922
E L E+ L L+ E+Q ++ E ++ + L Q++LE + S LE +L
Sbjct: 878 ESLEREKMELEMRLK-EQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQ 936
Query: 923 RSLE------RLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEE--EAAHHSHQQLVKVAL 974
E +L RL + + T T+ ++ E EAA L +
Sbjct: 937 TQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQE 996
Query: 975 EKSLAT-----VETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKE 1029
E S ++ Q DS R +++E+ +EK + +E
Sbjct: 997 ESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEV-----------QEKLRETQEYNR 1045
Query: 1030 LKAQIE-EAGFSSVSHIRNTMLSLCLENAEL--KEQMGEAMSDGWEIEEDKEKGEVMVET 1086
++ ++E E ++S + L L+ A+ ++++ D E + ++++ +E
Sbjct: 1046 IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMEL 1105
Query: 1087 VVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTI 1146
+ + E+ A+ +L +L+ +H + EQ + +S +L + L ST
Sbjct: 1106 LRQEVKEKEADFLAQEAQLLEELEASH-----ITEQQLRASLWAQEAKAAQLQLRLRSTE 1160
Query: 1147 ERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQS------QPRD 1200
++ +Q Q + + Q+L + + + +P
Sbjct: 1161 SQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQ 1220
Query: 1201 PGPQSAFSLPGSTQHLRSQL--SQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGE 1258
G +S F L ++ S + +QDL + ++ T ++++K LT
Sbjct: 1221 NGARSLFKRGPLLTALSAEAVASALHKLHQDLWK----TQQTRDVLRDQVQKLEERLTD- 1275
Query: 1259 SLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGR 1318
+ + Q+ +LQDL + S+N+ E+ + + + L E L E + S Q R
Sbjct: 1276 --TEAEKSQVHTELQDLQRQL---SQNQEEKSKWEGKQNSLESELME--LHETMASLQSR 1328
Query: 1319 RGSTLASSSERKPLENQLGKQEEFRVYGKSENILV----LRKDIKDLKAQLQNANKVIQN 1374
R L+ + E + EN+ L+ + + +AQ A + ++
Sbjct: 1329 L--------RRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEED 1380
Query: 1375 LKSRVRSLSVTSD-YSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQ 1433
L++ +L + ++ S ER L+ G L+ + + L + +
Sbjct: 1381 LRTARSALKLKNEEVESERERAQALQEQGELKVAQGKA--------LQENLALLTQTLAE 1432
Query: 1434 AKKDLESLIQRVSQLEAQ--LPKNGLE-----------------EKLAEELRSASWPGKY 1474
++++E+L ++ +LE Q + K LE E++ E + S
Sbjct: 1433 REEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHL 1492
Query: 1475 DSLIQDQARELSYLRQKIRE-------GRGIC--YLITRHAKDTV-----KSFEDL---- 1516
+Q++ ++L+ R++IRE R + L+ KD + +DL
Sbjct: 1493 PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQL 1552
Query: 1517 ---------LRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKD--HKSEKDQA----- 1560
L N Q ++L +G + T+R+ T D +S++ QA
Sbjct: 1553 VTLECLALELEENHHKMECQQKLIKEL-EGQRETQRVALTHLTLDLEERSQELQAQSSQI 1611
Query: 1561 -GLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEA 1619
LE + L+RELQE+++ EV + L H D R + ++
Sbjct: 1612 HDLESHSTVLARELQERDQ--EVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQV 1669
Query: 1620 CSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSSTSASQG---AKAESNSNPI 1676
D E+ + S+ + A +G +KA+ S
Sbjct: 1670 LEDQRTRQTKILEEDLEQIKL---SLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEH 1726
Query: 1677 SLPTPQNTPKEANQAHSGFHFHSIPKLASLPQAPLPSAPSSFLPFSPTGPLLLGCCETPV 1736
++ KE H H + +L + L L ET +
Sbjct: 1727 MKLILRDKEKEVECQQE--HIHELQELKDQLEQQLQG-------------LHRKVGETSL 1771
Query: 1737 VSLAEAQQELQMLQKQLGESASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIEL 1796
+ L++ +QE+ +LQ+QL E+ L L++ L+ AQ R EL
Sbjct: 1772 L-LSQREQEIVVLQQQLQEAREQ------GELKEQSLQSQ----LDEAQRALAQRDQ-EL 1819
Query: 1797 GRILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQ 1856
L+ + G+ + ++ + ++ G L L+E GE+++ ++
Sbjct: 1820 -EALQQEQQQAQGQEERVKEKADALQGALEQAHMT------------LKERHGELQDHKE 1866
Query: 1857 ---RLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRR 1913
RLEE + + R + LE E + L E+R +
Sbjct: 1867 QARRLEEELAVEGRRVQALE---------------------EVLGDLRAESREQEKALLA 1905
Query: 1914 LQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLH 1973
LQ Q + ++EH ET +L+++ L +++ L+E ++ELE + E Q Q+E
Sbjct: 1906 LQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQS-----SRHQEEAAR 1960
Query: 1974 FREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLD 2033
R E +LQE + L +Q E+ +L SL++ +A SLD
Sbjct: 1961 ARAE--ALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQA------------SLD 2006
Query: 2034 AC--HQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQL 2076
AC H L L E++ + ++ +Q QLQQ L
Sbjct: 2007 ACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQ-------QLQQAL 2044
Score = 135 bits (340), Expect = 5e-31
Identities = 363/1707 (21%), Positives = 686/1707 (40%), Gaps = 286/1707 (16%)
Query: 32 RMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQF 91
++++K+E R EL +ESL+RE + + L + ++E + +Q E E R Q
Sbjct: 857 QLREKWEKERS---WHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEE-RTQA 912
Query: 92 E----ERQQETE-HVYELLENKIQL-------------LQEESRLAKNEAARMAALVEAE 133
E + Q ETE LLE +Q L+++ ++ K + +++ +
Sbjct: 913 ESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQ 972
Query: 134 -KECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQ---ERLV 189
+E EL E + ++ +D+ Q + + K++E+L L AQ +RLV
Sbjct: 973 LQEAQRELKEAAR---QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLV 1029
Query: 190 EQLSREK---QQLLHLLEEPTSMEVQPMTEELL-KQQKLNSHETTITQQSVSDSHLAELQ 245
EQ +EK Q + +++ E +T L+ K+Q+L + S+ L+ L+
Sbjct: 1030 EQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEA---DSIRQQELSALR 1086
Query: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE 305
+ +Q+ + K L ++ + E+K + Q+ L E L++ ++L +
Sbjct: 1087 QDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEA---QLLEELEASHITEQQLRASLW 1143
Query: 306 GQNDTMAKLREMLH--QSQLGQLHSSEGT-SPAQQQVALLDLQSALFCSQLEIQKLQRVV 362
Q A+L+ L +SQL L + + + AQ Q L L SAL Q+ V
Sbjct: 1144 AQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSAL-------QQALGSV 1196
Query: 363 RQKERQLA---DAKQCVQFVE---------------AAAHESEQQKEASWKHNQELRKAL 404
+ +L+ D+ V +E A +E A K +Q+L K
Sbjct: 1197 CESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQ 1256
Query: 405 QQ---LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD 461
Q L++++Q ++L EAEK +++ T+ Q++Q R+L Q ++
Sbjct: 1257 QTRDVLRDQVQKLEERLTDTEAEK-SQVHTELQDLQ----------------RQLSQNQE 1299
Query: 462 NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLE 521
K E + LE +H+ +L+ + E + E L+ A +E
Sbjct: 1300 EKSK-WEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVE 1358
Query: 522 RLRDVLSSNEATMQS---MESLLR----AKGLEVEQLSTTCQNLQWLKEEMETKFSRWQK 574
L+ + A + +E LR A L+ E++ + + Q L+E+ E K ++ +
Sbjct: 1359 HLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKA 1418
Query: 575 EQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDR 634
QE++ QT L +R +EVE L GQ + E+ + + +L L R
Sbjct: 1419 LQENLALLTQT-LAEREEEVETLR---------GQIQELEKQREMQKAALELLSLDLKKR 1468
Query: 635 NKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLG--GRDSLMS 692
N++V + +IQ L ++ ++ E L A+ ER +L R+ + +D
Sbjct: 1469 NQEVDLQQEQIQEL--------EKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQ 1520
Query: 693 QAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLE 752
+ + +Q E+ + D + + V + L L+ +A LE
Sbjct: 1521 RNVLEHQLLEL------------------EKKDQMIESQRGQVQDLKKQLVTLECLA-LE 1561
Query: 753 KELSNAKEELELMAKKERESQME-----LSALQSMMAVQEEELQVQAA---DMES----L 800
E ++ K E + KE E Q E L+ L + + +ELQ Q++ D+ES L
Sbjct: 1562 LEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVL 1621
Query: 801 TRNIQIKEDLIKDLQMQLVDPED-----IPAMERLTQEVLLLREKVASVESQGQEISGNR 855
R +Q ++ +K + Q+ + + +ER QE++L +E++ +E Q R
Sbjct: 1622 ARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQ-------R 1674
Query: 856 RQQLLLMLEGLVDERSRLNE---ALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQV 912
+Q ++ E L + L E L +RQL + P ++R ++L +
Sbjct: 1675 TRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKL----I 1730
Query: 913 LRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKV 972
LR + +EV + E ++ L+ L D E + E + S ++ V
Sbjct: 1731 LRDKEKEVECQQ-EHIHELQELK--------DQLEQQLQGLHRKVGETSLLLSQREQEIV 1781
Query: 973 ALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKA 1032
L++ L Q G + LQ ++ + Q +E ++E ++ +
Sbjct: 1782 VLQQQLQEAREQ----------GELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQG 1831
Query: 1033 QIEEAGFSSVSHIRNTMLSLCLENAE--LKEQMGEAMSDGWEIEEDKEKGEVMVETVVTK 1090
Q E + L LE A LKE+ G E+++ KE+ + E +
Sbjct: 1832 QEERV------KEKADALQGALEQAHMTLKERHG-------ELQDHKEQARRLEEELAV- 1877
Query: 1091 EGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEG--NSKLTPELLVHLTSTIER 1148
EG +L+ L+ + + + L++Q ++E ++ + + + ++
Sbjct: 1878 EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKE 1937
Query: 1149 INTELVGSPGKHQ---HQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQS 1205
+ EL + Q HQEE R ++ L L + Q +
Sbjct: 1938 RDQELEALRAESQSSRHQEEA-------ARARAEALQEALGKAHAALQGKEQHLLEQAEL 1990
Query: 1206 AFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATV-----------------FAQANE- 1247
+ SL ST L++ L C+ + L+E L + E + AQ +E
Sbjct: 1991 SRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEE 2050
Query: 1248 --LEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKE 1305
++ R L +SL ++ + + + Q+LG E R E E + E + + KE
Sbjct: 2051 LRHQQEREQLLEKSLAQRVQENMIQEKQNLGQE---REEEEIRGLHQSVRELQLTLAQKE 2107
Query: 1306 MVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQL 1365
++E ++Q L S + P+E Q K + L+++++ L+A L
Sbjct: 2108 QEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPR--------LQRELERLQAAL 2159
Query: 1366 Q--NANKVIQNLKSR--VRSLSVTSDYSSSLERPWKLRAVGTLE-GSSPHSVPDEDE-GW 1419
+ A ++ K++ SL+ T SSL+ LE S + DE E
Sbjct: 2160 RQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTR 2219
Query: 1420 LSDGTGAFYSPGLQAKKDLES------LIQRVSQLEAQLPKNGLEEKLAEELRSASWPGK 1473
+ +SPG + +L S + VS +EA+ +G+E++ SW +
Sbjct: 2220 RALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQ--------SWRQR 2271
Query: 1474 YDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQ 1533
+ L Q AR L R +++ RH + E + R ++ R
Sbjct: 2272 LEHLQQAVAR-LEIDRSRLQ----------RHNVQLRSTLEQVERER--RKLKREAMRAA 2318
Query: 1534 LAQGSQLTERLTSKLSTKDHKSEKDQ-----AGLEPLALRLSREL-----QEKEKVIEVL 1583
A ++++ S + +D + +K+ A L+ + L +L Q+++ +
Sbjct: 2319 QAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSA 2378
Query: 1584 QAKLDARSLTPSSSHALSDSHRSPSST 1610
Q + L S SH+L ++P +T
Sbjct: 2379 QTSRELAGLHHSLSHSLLAVAQAPEAT 2405
Score = 94.0 bits (232), Expect = 2e-18
Identities = 403/2074 (19%), Positives = 793/2074 (38%), Gaps = 378/2074 (18%)
Query: 104 LLENKIQLLQEESRLAKNEAARMAALVEAEK--ECNLELSEKLKGVTKNWEDVPGDQVKP 161
+LE ++ LQ++ +A+N+AA L +++ + L KL Q K
Sbjct: 19 VLEEQVLALQQQ--MAENQAASWRKLKNSQEAQQRQATLVRKL-------------QAKV 63
Query: 162 DQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQ 221
QY + +KR+E + + VE+ + + +LL LEE +Q
Sbjct: 64 LQYRSWCQELEKRLEATGGPIPQRWENVEEPNLD--ELLVRLEE--------------EQ 107
Query: 222 QKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDG 281
Q+ S TQ L+ +++ + NK L+E + +++ + A++ +++
Sbjct: 108 QRCESLAEVNTQ----------LRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKES 157
Query: 282 TIQNLKETLKSRERETEELYQVIEGQNDTMAKL-REML-HQSQLGQLHSSEGTSPAQQQV 339
Q +E K ++G++ + L RE++ + ++ S+ + +
Sbjct: 158 QWQMEQEFFKG----------YLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKA 207
Query: 340 ALLDLQSALF--CSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHN 397
+ L +L C +L + R R D ++ Q + A E +KEA + +
Sbjct: 208 EHVRLSGSLLTCCLRLTVGAQSREPNGSGRM--DGREPAQLLLLLAKTQELEKEAH-ERS 264
Query: 398 QELRKALQQ---LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFR 454
QEL + Q + ELQ++ +L A + + E+ I+ L ++ E L
Sbjct: 265 QELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETV---EILETNHT 321
Query: 455 ELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQL---RL 511
EL+++ + + + ++ L+++ + I V +E + + E EL +
Sbjct: 322 ELMEHEASLSRNAQEEKLSLQQVIKDITQ--VMVEEGDNIAQGSGHENSLELDSSIFSQF 379
Query: 512 AVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSR 571
++ D L +R VL+ +Q + L CQ L ++ + +
Sbjct: 380 DYQDADKALTLVRSVLTRRRQAVQDLRQQLAG-----------CQEAVNL---LQQQHDQ 425
Query: 572 WQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAE-ELCQRLQRKERMLQDL 630
W++E +++ Q+LQ +R + L+ + G S E EL Q+ + + R ++
Sbjct: 426 WEEEGKALRQRLQKLTGER----DTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEV 481
Query: 631 LSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSL 690
L ++ +E+Q S +++E Q E+L A+ ER + L++ L G ++
Sbjct: 482 LEQEAWRLRRVNVELQLQGDSAQGQKEEQQ---EELHLAVRER----ERLQEMLMGLEAK 534
Query: 691 MSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAG 750
S++ +T L +G + + + T+ A+ + SI
Sbjct: 535 QSES----LSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIA------------ 578
Query: 751 LEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADME----SLTRNIQI 806
ELS+++ L+ R + ++LSAL +A+ + L Q +E S+ ++
Sbjct: 579 ---ELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA 635
Query: 807 KEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL 866
E LQ+ L + E E L ++ L ++ E G E+ + R + E
Sbjct: 636 AEQARNALQVDLAEAEK--RREALWEKNTHLEAQLQKAEEAGAELQADLRD----IQEEK 689
Query: 867 VDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLE 926
+ + +L+E+ + + L + H + E V+ + A V EV +++E
Sbjct: 690 EEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVE 749
Query: 927 RLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNP 986
R +R + + G ++ + ++S + E +S ++ K LE + TV
Sbjct: 750 R-DRQDLAEQLQGLSSAKELLESS------LFEAQQQNSVIEVTKGQLEVQIQTVTQAKE 802
Query: 987 SFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLE----EKRKAEEELKELKAQIEEAGFSSV 1042
RCL+ E+ R++ Q + + +AE+E K Q + A V
Sbjct: 803 VIQ-------GEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEV 855
Query: 1043 SHIRNTM-LSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAE 1101
+ +R EL + + + E+E ++ + +E + + E QAE
Sbjct: 856 NQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQR--EEERTQAE 913
Query: 1102 FRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQ 1161
Q +L+ ++LL E L+ + KE L + +ER+ ++ K Q
Sbjct: 914 SALCQMQLETEKERVSLL-ETLLQTQKE---------LADASQQLERLRQDMKVQKLKEQ 963
Query: 1162 HQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLS 1221
++ L Q + +L
Sbjct: 964 ------------------------------------------ETTGILQTQLQEAQRELK 981
Query: 1222 QCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQ-IQVDLQDLGYET- 1279
+ ++++D L +++ +L+K L + + + DS++ ++ ++Q+ ET
Sbjct: 982 EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQ 1041
Query: 1280 -CGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGK 1338
R + E ERE+ + + +VL E Q S+ R+ ++ G+
Sbjct: 1042 EYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQEL------SALRQDMQEAQGE 1095
Query: 1339 QEEFRVYGKSENILVLRKDIKDLKAQ-LQNANKVIQNLKSRVRSLSVTSDYSSSLERPWK 1397
Q+E S + +LR+++K+ +A L ++++ L++ S +SL W
Sbjct: 1096 QKEL-----SAQMELLRQEVKEKEADFLAQEAQLLEELEA---SHITEQQLRASL---WA 1144
Query: 1398 LRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPG--LQAKKDLESLIQRVSQLEAQLPKN 1455
A S + E ++ PG QA+ L SL + Q + ++
Sbjct: 1145 QEAKAAQLQLRLRSTESQLEALAAE-----QQPGNQAQAQAQLASLYSALQQALGSVCES 1199
Query: 1456 GLEEKLAEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFED 1515
E + + W + D Q+ AR L + G L+T + + V S
Sbjct: 1200 RPELSGGGDSAPSVWGLEPD---QNGARSL------FKRGP----LLTALSAEAVASALH 1246
Query: 1516 LLRSNDIDYYLGQSFREQLA-QGSQLTERLTSKLSTKDHKSEKDQAG--LEPLALRLSRE 1572
L D + Q R+ L Q +L ERLT D ++EK Q L+ L +LS+
Sbjct: 1247 KLHQ---DLWKTQQTRDVLRDQVQKLEERLT------DTEAEKSQVHTELQDLQRQLSQN 1297
Query: 1573 LQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHY 1632
+EK K E Q L++ + + A S + +EA + +++
Sbjct: 1298 QEEKSKW-EGKQNSLESELMELHETMASLQSRLRRAELQ----RMEAQGERELL------ 1346
Query: 1633 EEKKASPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAH 1692
+ A + + + H +AV+ ++ +++A G E S +N E+ +
Sbjct: 1347 --QAAKENLTAQVEHLQ-AAVVEARAQASAA--GILEEDLRTARSALKLKNEEVESERER 1401
Query: 1693 SGFHFHSIPKLASLPQAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQ 1752
+ ++ + L A + + + T LAE ++E++ L+ Q
Sbjct: 1402 A----QALQEQGELKVAQGKALQENLALLTQT--------------LAEREEEVETLRGQ 1443
Query: 1753 LGESASTVPPASTAT-LLSNDLEA---DSSYYLNSAQPHSPPRGTIELGRILEPGYLGSS 1808
+ E A LLS DL+ + Q R +E L
Sbjct: 1444 IQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEH---LPMAVQERE 1500
Query: 1809 GKWDVMRPQKGSVSGDLSSGSSV--YQLNSKPTGADLLEEHLGEIRNLRQRLEESICIND 1866
K V R Q + D + +V +QL ++E G++++L+++L C+
Sbjct: 1501 QKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLAL 1560
Query: 1867 RLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHS 1926
L E H++ E +L E RE R L+ E S
Sbjct: 1561 ELEEN-HHKM------------------ECQQKLIKELEGQRETQRVALTHLTLDLEERS 1601
Query: 1927 QETESLREALLSSRSHLQELEKELEHQ--------------------------------- 1953
QE ++ + SH L +EL+ +
Sbjct: 1602 QELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELM 1661
Query: 1954 -KVERQQLLEDLREKQQEVLH--FREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQ 2010
+ ER Q+LED R +Q ++L + +LSL+E L + L+Q++ EE + ++ +
Sbjct: 1662 LQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQR 1721
Query: 2011 SELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQ------G 2064
L+ + + + +K ++ C Q + E++ L+ QLEQ +Q G
Sbjct: 1722 GSLEHMKLILRDKEKEVE------CQQ--------EHIHELQELKDQLEQQLQGLHRKVG 1767
Query: 2065 NNCLRLQ--------LQQQLESGAGKASLSPSSI 2090
L L LQQQL+ + L S+
Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEAREQGELKEQSL 1801
Score = 48.5 bits (114), Expect = 8e-05
Identities = 58/212 (27%), Positives = 90/212 (42%), Gaps = 23/212 (10%)
Query: 1827 SGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGST 1886
S SS +Q + A+ L+E LG+ Q E+ + L LE T+T +
Sbjct: 1949 SQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAS-TATLQASLDA 2007
Query: 1887 SNFYSQGLESI-----PQLCNENRVLREDNRRLQAQLSHVSRE--HSQETESLREALLSS 1939
+S+ LE ++ +++ +ED ++LQ L+ E H QE E L E L+
Sbjct: 2008 CQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQ 2067
Query: 1940 R------SHLQELEKELE-------HQKVERQQLLEDLREKQQEVLHFREERLSLQENDS 1986
R Q L +E E HQ V QL L +K+QE+L RE +
Sbjct: 2068 RVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLT--LAQKEQEILELRETQQRNNLEAL 2125
Query: 1987 RLQHKLVLLQQQCEEKQQLFESLQSELQIYEA 2018
HK +++Q + L LQ EL+ +A
Sbjct: 2126 PHSHKTSPMEEQSLKLDSLEPRLQRELERLQA 2157
Score = 43.9 bits (102), Expect = 0.002
Identities = 49/218 (22%), Positives = 101/218 (46%), Gaps = 30/218 (13%)
Query: 1906 VLREDNRRLQAQLSHVSREHSQETESLRE---ALLSSRSHLQELEKELEHQKV---ERQQ 1959
+L+ + Q +L +R+H + +L+E +LL + LQ+ ++L+ Q V + Q+
Sbjct: 968 ILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQR 1027
Query: 1960 LLE-DLREKQQEVLHFREERLSLQENDSRL-------QHKLVLLQQQCEEKQQLFESLQS 2011
L+E +++EK +E + + L+ + L + +L++LQ+ +QQ +L+
Sbjct: 1028 LVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQ 1087
Query: 2012 ELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQ 2071
++Q G K+ L A ++ L ++ A+ A QL + ++ ++ Q
Sbjct: 1088 DMQ---EAQGEQKE------LSAQMEL-LRQEVKEKEADFLAQEAQLLEELEASHITEQQ 1137
Query: 2072 LQQQLESGAGKAS------LSPSSINQNFPASTDPGNK 2103
L+ L + KA+ S S + A PGN+
Sbjct: 1138 LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQ 1175
Score = 37.0 bits (84), Expect = 0.23
Identities = 48/211 (22%), Positives = 84/211 (39%), Gaps = 18/211 (8%)
Query: 1895 ESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKE---LE 1951
+ + +L E L LQ ++ +S+E E L++A R L+ LE+E L
Sbjct: 435 QRLQKLTGERDTLAGQTVDLQGEVDSLSKER----ELLQKAREELRQQLEVLEQEAWRLR 490
Query: 1952 HQKVERQ---QLLEDLREKQQEVLHF--------REERLSLQENDSRLQHKLVLLQQQCE 2000
VE Q + +E+QQE LH +E + L+ S +L+ L++ E
Sbjct: 491 RVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALE 550
Query: 2001 EKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQ 2060
E L+ E A +++ + S +DL ++ AL L
Sbjct: 551 SSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALAL 610
Query: 2061 SIQGNNCLRLQLQQQLESGAGKASLSPSSIN 2091
G N LQL+++ +S + + + N
Sbjct: 611 DKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 146 bits (369), Expect = 2e-34
Identities = 245/1116 (21%), Positives = 485/1116 (43%), Gaps = 160/1116 (14%)
Query: 29 LEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELR 88
L+ +K A+ ++ +++ + + E+ ++EL++K L K D++ L Q+EA+
Sbjct: 843 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQ-LQVQSEADSL 901
Query: 89 RQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVT 148
EER ++ L++NKIQL E+++ + + E E+E N EL+ K + +
Sbjct: 902 ADAEERCEQ------LIKNKIQL---EAKIKE-----VTERAEEEEEINAELTAKKRKLE 947
Query: 149 KNWEDVPGDQVKPDQYTEALAQRDK-----RIEELNQSLAAQERLVEQLSREKQQLLHLL 203
++ D + + T A +++K +++ L + +A + + +LS+EK+ L
Sbjct: 948 DECSELKKD-IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKAL---- 1002
Query: 204 EEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLN 263
+E + + E K L +T + QQ + +L+ ++Q + L+
Sbjct: 1003 QETHQQTLDDLQAEEDKVNILTKAKTKLEQQ------VDDLEGSLEQEKKLRMDLERAKR 1056
Query: 264 EMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQL 323
++ +LK AQES+ + Q L E L+ +E E L IE + +L
Sbjct: 1057 KLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQL--------- 1107
Query: 324 GQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQ--LADAKQCVQFVEA 381
Q+++ L + ++E ++ R +K+R + ++ + +E
Sbjct: 1108 ------------QKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1155
Query: 382 AAHESEQQKEASWKHNQELRKALQQLQE-ELQNKSQ--QLRAWEAEKYNEIRTQEQNIQH 438
A + Q E + K E +K + L+E LQ+++ LR A+ E+ Q N+Q
Sbjct: 1156 AGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQR 1215
Query: 439 LNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSA 498
+ K++L +E EL D+ L +N + K + + R+++++ S
Sbjct: 1216 V------KQKLEKEKSELKMETDD----LSSNAEAISKAKGNLEKMC----RSLEDQVSE 1261
Query: 499 LEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNL 558
L+ KE+E ++L D +R R + E + Q L K V QLS + Q
Sbjct: 1262 LKTKEEEQQRL-----INDLTAQRARLQTEAGEYSRQ-----LDEKDALVSQLSRSKQAS 1311
Query: 559 QWLKEEMETKFSRWQKEQESIIQQLQTSLHD------RNKEVEDLSATLLCKLGPGQSEI 612
EE++ + K + ++ LQ+S HD + +E ++ A L L SE+
Sbjct: 1312 TQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEV 1371
Query: 613 AE-------ELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEK 665
A+ + QR + E + L+ R ++ EH + S+ +Q Q E
Sbjct: 1372 AQWRTKYETDAIQRTEELEE-AKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVED 1430
Query: 666 LVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDD 725
L+ + N+ AL + D ++S+ Q+ E T Q + + Q SR
Sbjct: 1431 LMLDVERSNAACAALDKKQRNFDKVLSE---WKQKYEET-------QAELEASQKESRSL 1480
Query: 726 STSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSM-MA 784
ST L ++V +L L+T L +E N ++E+ + ++ E ++ L+ +
Sbjct: 1481 STELFKVKNVY--EESLDQLET---LRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQ 1535
Query: 785 VQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASV 844
V++E+ ++QAA +E +++ +E I +Q++L ++ EV K+A
Sbjct: 1536 VEQEKCEIQAA-LEEAEASLEHEEGKILRIQLEL---------NQVKSEV---DRKIAEK 1582
Query: 845 ESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKF-----HAH---PES 896
+ + ++ N + + M L E N+AL+ ++++ L + HA+ ES
Sbjct: 1583 DEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAES 1642
Query: 897 SERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDS 956
R Q L+ Q+ L++ L R E L E LA + A E T
Sbjct: 1643 LRNYRNTQGILKETQL---HLDDAL-RGQEDLK--EQLAIVERRANLLQAEIEELWATLE 1696
Query: 957 IEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQH 1016
E + + Q+L+ + + + + TQN S ++ + L+ ++ L++E +
Sbjct: 1697 QTERSRKIAEQELLDAS--ERVQLLHTQNTSLI-------NTKKKLENDVSQLQSEVEEV 1747
Query: 1017 LEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEED 1076
++E R AEE+ K+ I +A + + S LE +K+ + + + D ++
Sbjct: 1748 IQESRNAEEKAKK---AITDAAMMAEELKKEQDTSAHLE--RMKKNLEQTVKDLQHRLDE 1802
Query: 1077 KEKGEVMVETVVTKEGLSE-SSLQAEFRKLQGKLKN 1111
E+ + K G + L+A R+L+G+++N
Sbjct: 1803 AEQ-------LALKGGKKQIQKLEARVRELEGEVEN 1831
Score = 94.7 bits (234), Expect = 9e-19
Identities = 223/1142 (19%), Positives = 461/1142 (40%), Gaps = 203/1142 (17%)
Query: 286 LKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQ 345
+K LKS E E E MA ++E +++ A+ + +L+
Sbjct: 839 IKPLLKSAETEKE------------MATMKEEFQKTK---------DELAKSEAKRKELE 877
Query: 346 SALFCSQLEIQKLQRVVRQKERQLADAKQ-CVQFV------EAAAHESEQQKEASWKHNQ 398
+ E LQ V+ + LADA++ C Q + EA E ++ E + N
Sbjct: 878 EKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINA 937
Query: 399 ELRKALQQLQEE---LQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF-R 454
EL ++L++E L+ L A+ E E +++L ++ ++ + + +
Sbjct: 938 ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSK 997
Query: 455 ELLQYRDNSDKTLEANEMLLEKLRQRIHDKA-VALERAIDEKFSALEEKEKELRQLRLAV 513
E ++ +TL+ ++ E+ + I KA LE+ +D+ +LE+++K L A
Sbjct: 998 EKKALQETHQQTLD--DLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAK 1055
Query: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573
R+ + DL+ ++ E Q ++ L K E+ L + ++ Q ++ +++ K
Sbjct: 1056 RKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKK----- 1110
Query: 574 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 633
I++LQ + + +E+E AE + K+R SD
Sbjct: 1111 ------IKELQARIEELGEEIE-----------------AERASRAKAEKQR------SD 1141
Query: 634 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 693
+++ L+ +S R +E+ A V+ +R +E Q LR+ L +L +
Sbjct: 1142 LSRE-----------LEEISERLEEAGGATSAQVELNKKREAEFQKLRRDL-EEATLQHE 1189
Query: 694 APISN-QQAEVTPTGCLGKQTD--QGSMQIPSRDDSTSLTAKEDVSIPRSTL----GDLD 746
A ++ ++ LG+Q D Q Q ++ S +D+S + G+L+
Sbjct: 1190 AMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLE 1249
Query: 747 TVA-GLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQ 805
+ LE ++S K + E + + + + LQ+ +L + A + L+R+ Q
Sbjct: 1250 KMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQ 1309
Query: 806 IKEDLIKDLQMQLVDPEDIP-----AMERLTQEVLLLREKVASVESQG-----QEISGNR 855
I++L+ QL + A++ + LLRE+ E +G + +S
Sbjct: 1310 ASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEE-EQEGKAELQRALSKAN 1368
Query: 856 RQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPES-SERDRTLQVELEGAQVLR 914
+ + D R E +A+++L L + H E+ + + +L+ + Q L+
Sbjct: 1369 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLE---KTKQRLQ 1425
Query: 915 SRLEEVLGRSLERLNRLETLAAIGGAAAGDDT---------EDTSTEFTDSIEEEAAHHS 965
+ +E+++ +ER N AA+ D E+T E S +E + +
Sbjct: 1426 NEVEDLM-LDVERSN--AACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLST 1482
Query: 966 HQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLR-------AEFHQHLE 1018
VK E+SL +ET N+ LQ+E+ L + H+ +
Sbjct: 1483 ELFKVKNVYEESLDQLETLR-----------RENKNLQQEISDLTEQIAEGGKQIHELEK 1531
Query: 1019 EKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSD-GWEIEEDK 1077
K++ E+E E++A +EEA +S+ H +L + LE ++K ++ +++ EI++ K
Sbjct: 1532 IKKQVEQEKCEIQAALEEAE-ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK 1590
Query: 1078 EKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPE 1137
+VET+ +S+L AE R L+ + L E + + ++L E
Sbjct: 1591 RNHTRVVETM-------QSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHA--NRLAAE 1641
Query: 1138 LLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQ 1197
L + +T + + + QE+ + R +L
Sbjct: 1642 SLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANL------------------ 1683
Query: 1198 PRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTG 1257
L + L + L Q ++ + +++LL + E+ +++ T
Sbjct: 1684 -----------LQAEIEELWATLEQTERSRKIAEQELL----------DASERVQLLHTQ 1722
Query: 1258 ESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQG 1317
+ + K+++ D+ L ++E EE K+ + + +E+
Sbjct: 1723 NTSLINTKKKLENDVSQL----------QSEVEEVIQESRNAEEKAKKAITDAAMMAEEL 1772
Query: 1318 RRGSTLASSSER---------KPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNA 1368
++ ++ ER K L+++L + E+ + G + I L +++L+ +++N
Sbjct: 1773 KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENE 1832
Query: 1369 NK 1370
K
Sbjct: 1833 QK 1834
Score = 72.0 bits (175), Expect = 6e-12
Identities = 198/1061 (18%), Positives = 399/1061 (37%), Gaps = 143/1061 (13%)
Query: 562 KEEMETKFSRWQKEQESIIQQLQT---SLHDRNKEVEDLSATLL-----CKLGPGQSEIA 613
++E+E K KE+ + Q+Q+ SL D + E L + K ++E
Sbjct: 873 RKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEE 932
Query: 614 EELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLV---QAL 670
EE+ L K+R L+D S+ K + + E+ + + + E + + E++ + +
Sbjct: 933 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETI 992
Query: 671 MERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLT 730
+ + E +AL++ Q + + QAE L K + Q+ + S
Sbjct: 993 AKLSKEKKALQE--------THQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQE 1044
Query: 731 AKEDVSIPRSTL---GDLDTVAGLEKELSNAKEEL-ELMAKKERESQMELSALQSMMAVQ 786
K + + R+ GDL ++ N K++L E + KKE E +S ++ AV
Sbjct: 1045 KKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAV- 1103
Query: 787 EEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVES 846
E+Q+Q E R ++ E++ + + + + R +E+ E+ S
Sbjct: 1104 --EIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1161
Query: 847 QGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVE 906
E++ R + + R L EA + ++L K HA + L +
Sbjct: 1162 AQVELNKKREAEFQKL-------RRDLEEATLQHEAMVAALRKKHADSMAE-----LGEQ 1209
Query: 907 LEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSH 966
++ Q ++ +LE+ + L + A A G+ E D + E
Sbjct: 1210 IDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGN-LEKMCRSLEDQVSELKTKEEE 1268
Query: 967 QQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEE 1026
QQ + L A ++T+ G+ +R L E+ A Q K+ + ++
Sbjct: 1269 QQRLINDLTAQRARLQTE----------AGEYSRQLDEK----DALVSQLSRSKQASTQQ 1314
Query: 1027 LKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVET 1086
++ELK Q+EE + + + + + S + L+EQ E++++G+ ++
Sbjct: 1315 IEELKHQLEEET-KAKNALAHALQSSRHDCDLLREQY-----------EEEQEGKAELQR 1362
Query: 1087 VVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTI 1146
++K A Q + K + I +E +E KL + L +
Sbjct: 1363 ALSK---------ANSEVAQWRTKYETDAIQRTEEL-----EEAKKKLA-QRLQEAEEHV 1407
Query: 1147 ERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSA 1206
E +N + Q + +++++ + +
Sbjct: 1408 EAVNAKCASLEKTKQRLQ-------------------------NEVEDLMLDVERSNAAC 1442
Query: 1207 FSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEK----YRVMLTGESLVK 1262
+L ++ LS+ KQ+Y++ Q +L S+ + + EL K Y L ++
Sbjct: 1443 AALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLR 1502
Query: 1263 QDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGST 1322
+++K +Q ++ DL E + E + E+ + L E S + G
Sbjct: 1503 RENKNLQQEISDL-TEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKI 1561
Query: 1323 LASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSL 1382
L E NQ+ + + ++ K E I L+++ + +Q+ + ++SR +L
Sbjct: 1562 LRIQLEL----NQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQST--LDAEIRSRNDAL 1615
Query: 1383 SVTSDYSSSL-ERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLE-- 1439
V L E +L L S + + +G L + T L+ ++DL+
Sbjct: 1616 RVKKKMEGDLNEMEIQLNHANRLAAESLRNYRN-TQGILKE-TQLHLDDALRGQEDLKEQ 1673
Query: 1440 -SLIQR--------VSQLEAQLPKNGLEEKLAEE-------------LRSASWPGKYDSL 1477
++++R + +L A L + K+AE+ ++ S L
Sbjct: 1674 LAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL 1733
Query: 1478 IQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQG 1537
D ++ S + + I+E R + D E+L + D +L + +
Sbjct: 1734 ENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV 1793
Query: 1538 SQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEK 1578
L RL +K LE L E++ ++K
Sbjct: 1794 KDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQK 1834
Score = 71.6 bits (174), Expect = 8e-12
Identities = 98/465 (21%), Positives = 217/465 (46%), Gaps = 47/465 (10%)
Query: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQ------KYEASREDIYKRNIELKVE 54
+ N Y L L++EN +L+ I L E++ + + E ++ + + E++
Sbjct: 1487 VKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAA 1546
Query: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQE 114
+E + L+ ++ + + ++ + S+ + ++ + EE Q + ++E L
Sbjct: 1547 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDA 1606
Query: 115 ESRLAKNEAARMAALVEA---EKECNLELSEKLKGVT-KNWEDVPGDQVKPDQYTEALAQ 170
E R ++N+A R+ +E E E L + +L + +N+ + G +K Q A
Sbjct: 1607 EIR-SRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGI-LKETQLHLDDAL 1664
Query: 171 RDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELL----KQQKLNS 226
R + E+L + LA ER L E ++L LE+ T + +ELL + Q L++
Sbjct: 1665 RGQ--EDLKEQLAIVERRANLLQAEIEELWATLEQ-TERSRKIAEQELLDASERVQLLHT 1721
Query: 227 HETT-ITQQSVSDSHLAELQEKIQQTEATNKILQEKLNE-------MSYELKCAQESSQK 278
T+ I + ++ +++LQ ++++ ++ +EK + M+ ELK Q++S
Sbjct: 1722 QNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1781
Query: 279 QDGTIQNLKETLKSRERETEELYQV-IEGQNDTMAKL----REMLHQSQLGQLHSSE--- 330
+ +NL++T+K + +E Q+ ++G + KL RE+ + + Q ++E
Sbjct: 1782 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVK 1841
Query: 331 GTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQK 390
G +++V L Q+ + + +LQ +V + + ++ K+ A E+E+Q
Sbjct: 1842 GLRKHERRVKELTYQTEE--DRKNVLRLQDLVDKLQAKVKSYKR-------QAEEAEEQS 1892
Query: 391 EASWKHNQELRKALQQLQEE---LQNKSQQLRAWEAEKYNEIRTQ 432
A+ ++L+ L++ +E +++ +LR E + +I +
Sbjct: 1893 NANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKISAE 1937
Score = 48.9 bits (115), Expect = 6e-05
Identities = 56/272 (20%), Positives = 118/272 (43%), Gaps = 34/272 (12%)
Query: 1847 HLGEIRNLRQRLEESICINDRLR-------EQLEHRLTSTARGRGSTSNFYSQGLESIP- 1898
HL + ++ L+E + I +R E+L L T R R E +
Sbjct: 1659 HLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQL 1718
Query: 1899 ------QLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKE--- 1949
L N + L D +LQ+++ V +E E ++A+ + +EL+KE
Sbjct: 1719 LHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDT 1778
Query: 1950 ---LEHQKVERQQLLEDLREK--QQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQ 2004
LE K +Q ++DL+ + + E L + + +Q+ ++R++ ++ + + +
Sbjct: 1779 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAE 1838
Query: 2005 LFESLQS-ELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQ 2063
+ L+ E ++ E Y + D + + L + L A+V++ + Q E++ +
Sbjct: 1839 AVKGLRKHERRVKELTYQTEE--------DRKNVLRLQDLVDKLQAKVKSYKRQAEEAEE 1890
Query: 2064 GNNC---LRLQLQQQLESGAGKASLSPSSINQ 2092
+N +LQ +LE +A ++ S +N+
Sbjct: 1891 QSNANLSKFRKLQHELEEAEERADIAESQVNK 1922
Score = 40.0 bits (92), Expect = 0.027
Identities = 66/298 (22%), Positives = 113/298 (37%), Gaps = 57/298 (19%)
Query: 1818 KGSVSGDL--SSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICIN---------- 1865
K + GDL + S++ N K + LE+ EI NL ++E+ +
Sbjct: 1055 KRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKEL 1114
Query: 1866 ----DRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNE-----------NRVLRED 1910
+ L E++E S A+ S+ S+ LE I + E N+ +
Sbjct: 1115 QARIEELGEEIEAERASRAKAEKQRSDL-SRELEEISERLEEAGGATSAQVELNKKREAE 1173
Query: 1911 NRRLQAQLSHVSREHSQETESLREALLSSRSHL-----------QELEKELEHQKVERQQ 1959
++L+ L + +H +LR+ S + L Q+LEKE K+E
Sbjct: 1174 FQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDD 1233
Query: 1960 LLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEAL 2019
L + + + + SL++ S L+ K EE+Q+L L ++ +
Sbjct: 1234 LSSNAEAISKAKGNLEKMCRSLEDQVSELKTKE-------EEQQRLINDLTAQRARLQTE 1286
Query: 2020 YGNSKKGLKAYSLDACHQIPLSSDLSH----LVAEVRALRGQLEQSIQGNNCLRLQLQ 2073
G YS + L S LS ++ L+ QLE+ + N L LQ
Sbjct: 1287 AGE-------YSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQ 1337
Score = 37.7 bits (86), Expect = 0.13
Identities = 34/148 (22%), Positives = 71/148 (47%), Gaps = 22/148 (14%)
Query: 1871 QLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETE 1930
Q E R ST + N Y + L+ + LR +N+ LQ ++S ++ + ++ +
Sbjct: 1474 QKESRSLSTELFK--VKNVYEESLDQL-------ETLRRENKNLQQEISDLTEQIAEGGK 1524
Query: 1931 SLREALLSSRSHLQELEKELEHQKVERQQLLED----LREKQQEVLHFREERLSLQ-END 1985
+ E L++++K++E +K E Q LE+ L ++ ++L + E ++ E D
Sbjct: 1525 QIHE--------LEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVD 1576
Query: 1986 SRLQHKLVLLQQQCEEKQQLFESLQSEL 2013
++ K + Q ++ E++QS L
Sbjct: 1577 RKIAEKDEEIDQLKRNHTRVVETMQSTL 1604
Score = 37.4 bits (85), Expect = 0.17
Identities = 32/178 (17%), Positives = 80/178 (44%), Gaps = 4/178 (2%)
Query: 1839 TGADLLEEHLGEIRNLRQRLEESIC---INDRLREQLEHRLTSTARGRGSTSNFYSQGLE 1895
+ A+ + + G + + + LE+ + + +++L + LT+ + + YS+ L+
Sbjct: 1236 SNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLD 1295
Query: 1896 SIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKV 1955
L ++ ++ + + +L H E ++ +L AL SSR L ++ E ++
Sbjct: 1296 EKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQE 1355
Query: 1956 ERQQLLEDLREKQQEVLHFREE-RLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSE 2012
+ +L L + EV +R + + L+ L Q+ +E ++ E++ ++
Sbjct: 1356 GKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAK 1413
Score = 33.5 bits (75), Expect = 2.5
Identities = 75/372 (20%), Positives = 153/372 (41%), Gaps = 77/372 (20%)
Query: 1219 QLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYE 1278
+++ K+ +Q +++L SEA + ELE+ V L L +++ Q+QV
Sbjct: 851 EMATMKEEFQKTKDELAKSEA----KRKELEEKMVTL----LKEKNDLQLQV-------- 894
Query: 1279 TCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGK 1338
++EA+ CE+ +K + +E E +ER E ++
Sbjct: 895 -----QSEADSLADAEERCEQ--LIKNKIQLEAKIKEV----------TERAEEEEEINA 937
Query: 1339 QEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKL 1398
+ + + L+KDI DL+ L K +++V++L T + + E KL
Sbjct: 938 ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL--TEEMAGLDETIAKL 995
Query: 1399 RAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLI--------QRVSQLEA 1450
++ + + L D LQA++D +++ Q+V LE
Sbjct: 996 -------SKEKKALQETHQQTLDD---------LQAEEDKVNILTKAKTKLEQQVDDLEG 1039
Query: 1451 QLPKNGLEEKLAEELRSASWPGKYD-SLIQDQARELSYLRQKIREGRGICYLITRHAKDT 1509
L + E+KL +L A + D L Q+ ++ +Q++ E + + +
Sbjct: 1040 SLEQ---EKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDE------KLEKKEFEI 1090
Query: 1510 VKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRL 1569
+ ++ L + +E A+ +L E + ++ +++ K+EK ++ L
Sbjct: 1091 SNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASR-AKAEKQRSD-------L 1142
Query: 1570 SRELQEKEKVIE 1581
SREL+E + +E
Sbjct: 1143 SRELEEISERLE 1154
Score = 32.0 bits (71), Expect = 7.3
Identities = 33/160 (20%), Positives = 67/160 (41%), Gaps = 8/160 (5%)
Query: 1845 EEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQL---C 1901
++ L + R+ LEE + + + L+ ++ S A Q +++ QL
Sbjct: 863 KDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKI 922
Query: 1902 NENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLL 1961
E E+ + A+L+ R+ E L++ + L ++EKE + + + L
Sbjct: 923 KEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 982
Query: 1962 EDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEE 2001
E++ + + +E+ +LQE H+ L Q EE
Sbjct: 983 EEMAGLDETIAKLSKEKKALQET-----HQQTLDDLQAEE 1017
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 145 bits (367), Expect = 3e-34
Identities = 249/1181 (21%), Positives = 530/1181 (44%), Gaps = 139/1181 (11%)
Query: 6 RTLSQHLNDLKKENFSLKLRIYFLE--ER----MQQKYEASREDIYKRNIELKVEVESLK 59
R + + LN++++ L+ R L+ ER + +K + + E++ K + K +++ L+
Sbjct: 880 REVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEV-KTLTQEKDDLKQLQ 938
Query: 60 RELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLA 119
LQ ++ L D N+N + +LR E +Q E + L++KI
Sbjct: 939 ESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETI-NTLKSKIS--------- 988
Query: 120 KNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKP---DQYTEALAQRDKRIE 176
E +R + E E E +K+ G+ K +D+ + D + ++ ++I
Sbjct: 989 -EEVSRNLHMEENTGETKDEFQQKMVGIDKK-QDLEAKNTQTLTADVKDNEIIEQQRKIF 1046
Query: 177 ELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTE------ELLKQQKLNSHETT 230
L Q ++++E + EK+QL L+E M ++ E EL KQQ++ + E
Sbjct: 1047 SLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKN 1106
Query: 231 IT-----QQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESS--QKQDGTI 283
+ S + LAE++EK+++ ++ LQEK ++ L +E S QK+ I
Sbjct: 1107 HAIKKEGELSRTCDRLAEVEEKLKEK---SQQLQEKQQQL---LNVQEEMSEMQKKINEI 1160
Query: 284 QNLKETLKSRE-----RETEELYQVIEGQNDTMAKLREMLHQSQ-LGQLHSSEGTSPAQQ 337
+NLK LK++E ETE L ++ + N+ +++ + + + L +L S T
Sbjct: 1161 ENLKNELKNKELTLEHMETERL-ELAQKLNENYEEVKSITKERKVLKELQKSFETERDHL 1219
Query: 338 QVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHN 397
+ + ++++ ++ E++ +++ + + + ++ V A ++ +++ K
Sbjct: 1220 RGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQ 1279
Query: 398 QELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL 457
+E+ L + QE L N + E E+ T EQ+ + +L+ E E
Sbjct: 1280 EEI-PVLHEEQELLPNVKEVSETQETMNELELLT-EQSTTKDSTTLARIEMERLRLNEKF 1337
Query: 458 QYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 517
Q K+L L+ +++ + K L+ I E + ++E + + Q L ++E+D
Sbjct: 1338 QESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQ-SLNMKEKD 1396
Query: 518 HDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 577
++ + ++S E +LLR +E+E L + + LQ +EM++ KE++
Sbjct: 1397 NETTK---IVSEMEQFKPKDSALLR---IEIEMLGLS-KRLQESHDEMKSV----AKEKD 1445
Query: 578 SIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDL---LSDR 634
+ Q+LQ L + ++++ ++ K + E+ C L+ +E + +L LS++
Sbjct: 1446 DL-QRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCC-LKEQEETINELRVNLSEK 1503
Query: 635 NKQVLEHEMEIQGLLQSVSTREQESQAAAE----KLVQALMERNSELQALRQYLGGRDSL 690
++ + +++ + + + QE E K + + E+ +EL+ +++ +DS
Sbjct: 1504 ETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSA 1563
Query: 691 MSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAG 750
+ I ++ E+T Q Q +QI ++ +E + I R L +
Sbjct: 1564 LQS--IESKMLELTNR----LQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIV 1617
Query: 751 LEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESL-TRNIQIKED 809
+ + S KE L E+Q ++ ++ + +E+ + Q ++E++ T NI++ +
Sbjct: 1618 AKMKESQEKEYQFLKMTAVNETQEKMCEIEHL----KEQFETQKLNLENIETENIRLTQI 1673
Query: 810 LIKDLQ-MQLVDPE--DIPAME---RLTQEVLL--LREKVASVESQGQEISG-----NRR 856
L ++L+ M+ V E D+ ++E ++ ++ L LRE + + +E+
Sbjct: 1674 LHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEH 1733
Query: 857 QQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHP-ESSERDRTLQVELEGAQVLRS 915
Q+ + L G+V E++ NE ++ L S A + E R + L+ Q
Sbjct: 1734 QETIDKLRGIVSEKT--NEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETID 1791
Query: 916 RLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALE 975
+L ++ ++L+ ++ D E+++ + + I+E A+ HQ + L+
Sbjct: 1792 KLRGIVSEKTDKLSNMQK-----------DLENSNAKLQEKIQELKANE-HQL---ITLK 1836
Query: 976 KSLATVETQNPSFSPPSPMGGDSNRCLQE---EMLHLRAEFHQHLEEKRKAEEELKELKA 1032
K + + + D + L + E L+L + H++LEE + +E L+
Sbjct: 1837 KDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLR- 1895
Query: 1033 QIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVM----VETV- 1087
++EE +L LE +LKE + E + EI+++ + ++ ETV
Sbjct: 1896 RVEE--------------TLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVD 1941
Query: 1088 VTKEGLSESSLQ-AEFRKLQGKLKN--AHNIINLLKEQLVL 1125
+E +SE ++Q ++ +K K K+ I L K++L L
Sbjct: 1942 KLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQL 1982
Score = 129 bits (325), Expect = 3e-29
Identities = 268/1355 (19%), Positives = 550/1355 (40%), Gaps = 247/1355 (18%)
Query: 14 DLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIE-LKVEVESLKRELQDKKQHLDKT 72
DL+ E L ++ L E+ Q + +E I + +E +K+++ ++D KQ + +T
Sbjct: 572 DLENE---LSSKVELLREKEDQ-IKKLQEYIDSQKLENIKMDLSYSLESIEDPKQ-MKQT 626
Query: 73 WADVEN--LNSQNEAELRR----QFEERQQETEHVYELLENKIQL--------------L 112
D E L+++ E+ R + +E+ +E Y+ +EN IQL L
Sbjct: 627 LFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDL 686
Query: 113 QEESRLAKNEAARMAALVEAEKE----CNLELSEKLKGVTKNWEDVPGDQVKPDQYTEAL 168
++E + A NE ++ +L++ + CNLEL K+ + K K + EAL
Sbjct: 687 EKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELN-------KEVEENEAL 739
Query: 169 AQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSM---------EVQPMTEELL 219
+ + EL + ERL +++ + ++L + E + VQ + EE+
Sbjct: 740 REEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIG 799
Query: 220 KQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQ 279
K + + TT + +D + E K++ E+ M+ E+ + +QK
Sbjct: 800 KTK--DDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKF 857
Query: 280 DGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREML-HQSQLGQLHSSEGTSPAQQQ 338
D ++ LK L + +E +E + ++ + + M +L+E L ++ Q E T ++
Sbjct: 858 DSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKL 917
Query: 339 VALLDLQSALFCSQLEIQKLQRVVRQKERQL-ADAKQCVQFVEAAAHESEQQKEASWKHN 397
L+ L + ++++LQ ++ + QL +D V + E+ +H
Sbjct: 918 QQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQ 977
Query: 398 QELRKALQQLQEELQ-----------------------NKSQQLRAWEAE------KYNE 428
+ + ++ EE+ +K Q L A + K NE
Sbjct: 978 ETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNE 1037
Query: 429 IRTQEQNI-----------QHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKL 477
I Q++ I Q L ++ KEQL + +E ++ + + L L+K
Sbjct: 1038 IIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQ 1097
Query: 478 RQ-----------------RIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRE---RD 517
++ R D+ +E + EK L+EK+++L ++ + E +
Sbjct: 1098 QEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI 1157
Query: 518 HDLERLRDVLSSNEATMQSMES-------LLRAKGLEVEQLSTTCQNLQWLKEEMETKFS 570
+++E L++ L + E T++ ME+ L EV+ ++ + L+ L++ ET+
Sbjct: 1158 NEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERD 1217
Query: 571 RWQ-------------KEQESI----IQQLQTSLHDRNKEVEDLSATLL--CKLGPGQSE 611
+ KE+ I +++ Q ++ + + V + +A ++ L ++
Sbjct: 1218 HLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTK 1277
Query: 612 IAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAE----KLV 667
+ EE+ L ++ +L ++ Q +E+E+ L + +T++ + A E +L
Sbjct: 1278 LQEEI-PVLHEEQELLPNVKEVSETQETMNELEL--LTEQSTTKDSTTLARIEMERLRLN 1334
Query: 668 QALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGK-----QTDQGSMQIPS 722
+ E E+++L + ++ + + Q + L K + S+ +
Sbjct: 1335 EKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKE 1394
Query: 723 RDDSTS--LTAKEDVSIPRSTLGDLD-TVAGLEKELSNAKEELELMAKKERESQMELSAL 779
+D+ T+ ++ E S L ++ + GL K L + +E++ +AK++ + Q L
Sbjct: 1395 KDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVL 1454
Query: 780 QS--------------MMAVQEEELQV-------QAADMESLTRNIQIKEDLIKDLQMQL 818
QS EEEL+V Q + L N+ KE I +Q QL
Sbjct: 1455 QSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQL 1514
Query: 819 VDPED-----------------IPAMERLTQEVLLLRE----------KVASVESQGQEI 851
D I + + ++V L++ + S+ES+ E+
Sbjct: 1515 EAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLEL 1574
Query: 852 SGNRRQQLLLMLEGLV---DERSRLNEALQAER-QLYSSLVKFHAHPESS---------- 897
+ NR Q+ ++ ++ +E R+ EALQ ER QL + + A + S
Sbjct: 1575 T-NRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKM 1633
Query: 898 -----------------ERDRTLQVELEGAQVLRSRLEEVLGRSLER----------LNR 930
E+ T ++ LE + RL ++L +LE L
Sbjct: 1634 TAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRS 1693
Query: 931 LETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSP 990
+E + ++ +T T + EE H H + + ++K V + S
Sbjct: 1694 VEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISN 1753
Query: 991 PSPMGGDSNRCLQEEMLHLRAEF---HQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRN 1047
SN L+ + L ++ E H HL+E+++ ++L+ + ++ + + + N
Sbjct: 1754 MQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLEN 1813
Query: 1048 TMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVM--VETVVTKEGLSESSLQAEFRKL 1105
+ L + ELK + ++ ++ E ++K M ++ + + L+ S L+ E L
Sbjct: 1814 SNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNL 1873
Query: 1106 QGKL-KNAHNIINLLKEQLVLSSKEGNSKLTPELL 1139
KL +N + +++KE+ L E KL + L
Sbjct: 1874 AQKLHENLEEMKSVMKERDNLRRVEETLKLERDQL 1908
Score = 127 bits (318), Expect = 2e-28
Identities = 242/1137 (21%), Positives = 472/1137 (41%), Gaps = 204/1137 (17%)
Query: 31 ERMQQKYEASREDI---YKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAEL 87
++M + A +E + K NIE+ +E + R L D+ + + A +N + E EL
Sbjct: 1056 QQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGEL 1115
Query: 88 RR-----------------QFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALV 130
R Q +E+QQ+ +V E + + + E L KNE +
Sbjct: 1116 SRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENL-KNELKNKELTL 1174
Query: 131 EAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVE 190
E + LEL++KL +N+E+V +++ + K ++EL +S + +
Sbjct: 1175 EHMETERLELAQKLN---ENYEEV-----------KSITKERKVLKELQKSFETERDHLR 1220
Query: 191 QLSRE--------KQQL----LHLLEEPTSME-----VQPMTEELLKQQKLNSHETTITQ 233
RE K++L +HL E +++ V T +++ Q L T + +
Sbjct: 1221 GYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQE 1280
Query: 234 QSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGT----------- 282
+ EL +++ T QE +NE L+ E S +D T
Sbjct: 1281 EIPVLHEEQELLPNVKEVSET----QETMNE----LELLTEQSTTKDSTTLARIEMERLR 1332
Query: 283 ----IQNLKETLKSRERETEELY-----------QVIEGQNDTMAKLREML---HQSQLG 324
Q +E +KS +E + L Q+ E +T+AK++E QS
Sbjct: 1333 LNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNM 1392
Query: 325 QLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKE---RQLADAKQCVQFV-E 380
+ +E T + SAL ++E+ L + +++ + +A K +Q + E
Sbjct: 1393 KEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQE 1452
Query: 381 AAAHESEQQKE------ASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQ 434
ES+Q KE A +E K +E + +LR +EK EI T ++
Sbjct: 1453 VLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQK 1512
Query: 435 NIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAV-ALERAID 493
++ +N L +K Q + E E + S+ + NE+ K ++ D A+ ++E +
Sbjct: 1513 QLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKML 1572
Query: 494 EKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLST 553
E + L+E ++E +++ ++E++ +++R+++ L ++ + AK E ++
Sbjct: 1573 ELTNRLQESQEE---IQIMIKEKE-EMKRVQEALQIERDQLKENTKEIVAKMKESQE--- 1625
Query: 554 TCQNLQWLKEEMETKFSRWQKEQESIIQQLQT-SLHDRNKEVEDLSATLLCKLGPGQSEI 612
+ Q+LK + E E + +Q +T L+ N E E++ T +I
Sbjct: 1626 --KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLT----------QI 1673
Query: 613 AEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALME 672
E + ++ + DL S +E + + L +++ TR+ E Q + + L E
Sbjct: 1674 LHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETI-TRDLEKQEELKIVHMHLKE 1732
Query: 673 RNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAK 732
+ LR + + + ISN Q ++ + K D L +
Sbjct: 1733 HQETIDKLRGIVSEKTN-----EISNMQKDLEHSNDALKAQD--------------LKIQ 1773
Query: 733 EDVSIPRSTLGD----LDTVAGLEKE----LSNAKEELELMAKKERESQMELSALQSMMA 784
E++ I L + +D + G+ E LSN +++LE K +E EL A + +
Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLI 1833
Query: 785 VQEE---ELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKV 841
++ E Q + ++ME L + QIK+ + L + ++ E++ ++L + + E++
Sbjct: 1834 TLKKDVNETQKKVSEMEQLKK--QIKD---QSLTLSKLEIENLNLAQKLHENL----EEM 1884
Query: 842 ASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDR 901
SV + R L + E L ER +L E+LQ E+ RD
Sbjct: 1885 KSVMKE--------RDNLRRVEETLKLERDQLKESLQ----------------ETKARDL 1920
Query: 902 TLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEA 961
+Q EL+ A++L +E + + E+++ I + D + + E I+E
Sbjct: 1921 EIQQELKTARMLSKEHKETVDKLREKISE----KTIQISDIQKDLDKSKDELQKKIQE-- 1974
Query: 962 AHHSHQQLVKVALE-----KSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQH 1016
QL++V + K + +E F + S + ++ + L + H+
Sbjct: 1975 LQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNL----SMQSVRMDNFQLTKKLHES 2030
Query: 1017 LEEKR---KAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDG 1070
LEE R K +EL+ +K ++ ++ +R M++ +N ++K + +SDG
Sbjct: 2031 LEEIRIVAKERDELRRIKESLKMERDQFIATLRE-MIARDRQNHQVKPEK-RLLSDG 2085
Score = 105 bits (261), Expect = 7e-22
Identities = 201/990 (20%), Positives = 415/990 (41%), Gaps = 168/990 (16%)
Query: 14 DLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTW 73
D KEN K + ++E +++Y+ + E E+E LK + + +K +L+
Sbjct: 1607 DQLKEN--TKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLE--- 1661
Query: 74 ADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAE 133
++E N + L EE + T+ +L + L E +L +N + +E +
Sbjct: 1662 -NIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQ 1720
Query: 134 KECNL---------ELSEKLKG-VTKNWEDVPGDQVKPDQYTEALAQRDKRIEE----LN 179
+E + E +KL+G V++ ++ Q + +AL +D +I+E +
Sbjct: 1721 EELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAH 1780
Query: 180 QSLAAQERLVEQL----SREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQS 235
L Q+ +++L S + +L ++ ++ + + +E +++ K N H+ ++
Sbjct: 1781 MHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAK--LQEKIQELKANEHQLITLKKD 1838
Query: 236 VSD-----SHLAELQEKIQQTEAT-------NKILQEKLNEMSYELKCAQESSQKQDGTI 283
V++ S + +L+++I+ T N L +KL+E E+K S K+ +
Sbjct: 1839 VNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMK----SVMKERDNL 1894
Query: 284 QNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSP--------A 335
+ ++ETLK + +E Q +T A+ E+ + + ++ S E +
Sbjct: 1895 RRVEETLKLERDQLKESLQ------ETKARDLEIQQELKTARMLSKEHKETVDKLREKIS 1948
Query: 336 QQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQK---EA 392
++ + + D+Q L S+ E+QK + +++KE QL K+ V +E EQ K EA
Sbjct: 1949 EKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEA 2008
Query: 393 SWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQE 452
Q +R QL ++L +++R A++ +E+R +++++ ++Q +
Sbjct: 2009 QNLSMQSVRMDNFQLTKKLHESLEEIRI-VAKERDELRRIKESLK------MERDQFIAT 2061
Query: 453 FRELLQYRDNSDKTLEANEMLL----EKLRQRIHDKAVALERAIDEKFSALEEKEKELRQ 508
RE++ RD + ++ + LL + L + + +K ++ + +++S +++ + L +
Sbjct: 2062 LREMIA-RDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELL-KRYSEMDDHYECLNR 2119
Query: 509 LRLAVRERDHDLE-----RLRDVLSSNEATMQSMESLLRAK---GLE----VEQLSTTCQ 556
L L + E++ + + R++ LS + +E L A +E +++L
Sbjct: 2120 LSLDL-EKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLS 2178
Query: 557 NLQWLKEEMETKFSRW----------QKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLG 606
+ +KEE +++ QKE IQ LQ ++E+ DL KL
Sbjct: 2179 YVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDL------KLN 2232
Query: 607 PGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQS-VSTREQESQAAAEK 665
EE+ + E + +QVL + E+ L+ ++TR EK
Sbjct: 2233 QNMDLHIEEILKDFSESE---FPSIKTEFQQVLSNRKEMTQFLEEWLNTRFD-----IEK 2284
Query: 666 LVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDD 725
L + + N + + + R + ++ T + K+ +Q + +++
Sbjct: 2285 LKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSAT----ISKEWEQDLKSLKEKNE 2340
Query: 726 ---------STSLTAKEDVS-----------IPRSTLGDLDTVAGLEKELSNAKEELELM 765
TSL + V+ R+T + + LE L AKE
Sbjct: 2341 KLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK 2400
Query: 766 AKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDL-----------IKDL 814
K + Q EL ++A + ++ +E IQ+ +D I+DL
Sbjct: 2401 ESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL 2460
Query: 815 QMQLV--DPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSR 872
+M+LV D E + + +E+ + A+VE Q + I +LL R
Sbjct: 2461 KMKLVKIDLEKMKNAKEFEKEISATK---ATVEYQKEVI------RLL---------REN 2502
Query: 873 LNEALQAERQLYSSLVKFHAHPESSERDRT 902
L + QA+ +S++ H P+ S + T
Sbjct: 2503 LRRSQQAQD---TSVISEHTDPQPSNKPLT 2529
Score = 87.8 bits (216), Expect = 1e-16
Identities = 385/1983 (19%), Positives = 767/1983 (38%), Gaps = 274/1983 (13%)
Query: 153 DVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSME-V 211
+V D+ +Y + + K++EE++ AQ + EK QL LLEE ++ V
Sbjct: 337 EVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQ-------AMEKDQLAQLLEEKDLLQKV 389
Query: 212 QPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKC 271
Q E L + + S T+ Q+ + + K + T KI + K + + +
Sbjct: 390 QNEKIENLTRMLVTSSSLTLQQE-------LKAKRKRRVTWCLGKINKMKNSNYADQFNI 442
Query: 272 AQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQ--LHSS 329
+ K NL L+ + V DT++++ L Q + S
Sbjct: 443 PTNITTKTHKLSINL---LREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESE 499
Query: 330 EGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQ 389
+ A +LD + QL +K + ++ KE+ D + +
Sbjct: 500 LNSLRADYDNLVLDYE------QLRTEKEEMELKLKEKNDLDEFEAL------------- 540
Query: 390 KEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQL 449
E K +QE+ QL E+ N ++ AE YN Q L + LS K +L
Sbjct: 541 -ERKTKKDQEM-----QLIHEISNLKNLVK--HAEVYN---------QDLENELSSKVEL 583
Query: 450 LQE----FRELLQYRDNSDKTLEANEMLL----------EKLRQRIHD-KAVALERAIDE 494
L+E ++L +Y D+ + LE +M L ++++Q + D + VAL+ +
Sbjct: 584 LREKEDQIKKLQEYIDS--QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRES 641
Query: 495 KFSALE--EKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLS 552
F E E ++++++L ++ ++D++ + L + + +E L++ E+ +L+
Sbjct: 642 AFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLT 701
Query: 553 TTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSAT-----LLCKLGP 607
+ L + K E E I LQ L NKEVE+ A LL +L
Sbjct: 702 S-------LIDGKVPKDLLCNLELEGKITDLQKEL---NKEVEENEALREEVILLSELKS 751
Query: 608 GQSEIAEELCQRLQRKERMLQDLLSDRNK---QVLEHEMEIQGLLQSVSTREQESQAAAE 664
SE+ E L + +Q K L + S+++K +V+ E +QGLL+ + + ++ A +
Sbjct: 752 LPSEV-ERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIG-KTKDDLATTQ 809
Query: 665 KLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRD 724
++ + + L + ++ + Q V L K+ + + +
Sbjct: 810 SNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVN----LSKEAQKFDSSLGALK 865
Query: 725 DSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMA 784
S +E R L+ + L+++L N L+ + ERE + LQ +
Sbjct: 866 TELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTV---EREKTLITEKLQQTLE 922
Query: 785 VQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASV 844
+ + L + D++ L ++QI+ D +K D D M TQE L R + S+
Sbjct: 923 -EVKTLTQEKDDLKQLQESLQIERDQLKS------DIHDTVNMNIDTQEQL--RNALESL 973
Query: 845 ESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQ 904
+ Q QE + ++ + + E +Q + K ++ +TL
Sbjct: 974 K-QHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDK--KQDLEAKNTQTLT 1030
Query: 905 VELEGAQVLRS--RLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAA 962
+++ +++ ++ ++ E LE++ A + E T+ ++IE
Sbjct: 1031 ADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIA--------EKEQLKTDLKENIEMTIE 1082
Query: 963 HHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRK 1022
+ +L+ L+K V + N +++E E + + +
Sbjct: 1083 NQEELRLLGDELKKQQEIVAQEK-------------NHAIKKE-----GELSRTCDRLAE 1124
Query: 1023 AEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEV 1082
EE+LKE Q++E + +L++ E +E+++++ E IE K +
Sbjct: 1125 VEEKLKEKSQQLQEK--------QQQLLNVQEEMSEMQKKINE-------IENLKNE--- 1166
Query: 1083 MVETVVTKEGLSESSLQAEFRKLQGKL-KNAHNIINLLKEQLVLSSKEGNSKLTPELLVH 1141
+ + L+ ++ E +L KL +N + ++ KE+ VL + + + + H
Sbjct: 1167 -----LKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERD---H 1218
Query: 1142 LTSTIERINTELVGSPGK------HQHQEEGNVTVRPFPRPQSLDLGATF-TVDAHQLDN 1194
L I I E G K H H +E T+ R S T D +
Sbjct: 1219 LRGYIREI--EATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHT 1276
Query: 1195 QSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRV- 1253
+ Q P L + + + S+ + + L E+ ++T A+ E+E+ R+
Sbjct: 1277 KLQEEIPVLHEEQELLPNVKEV-SETQETMNELELLTEQSTTKDSTTLARI-EMERLRLN 1334
Query: 1254 --MLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEG 1311
+ +K +K+ + +L+ + + + E T + +E S +E L
Sbjct: 1335 EKFQESQEEIKSLTKE-RDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLN-- 1391
Query: 1312 LCSEQGRRGSTLASSSER-KPLENQLGKQEEFRVYGKSENILVLRKDIKDL---KAQLQN 1367
E+ + + S E+ KP ++ L + E + G S+ + ++K + K LQ
Sbjct: 1392 -MKEKDNETTKIVSEMEQFKPKDSAL-LRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQR 1449
Query: 1368 ANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTG-A 1426
+V+Q+ +++ ++ + LE +L+ ++ + T +
Sbjct: 1450 LQEVLQSESDQLKE-NIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIS 1508
Query: 1427 FYSPGLQAKKD-LESLIQRVSQLEAQL---PKNGLEEKLAEELRSASWPGKYDSLIQDQA 1482
L+A D L++ IQ + + E Q + ++EK+ E + DS +Q
Sbjct: 1509 TIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIE 1568
Query: 1483 RELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTE 1542
++ L +++E + ++ + ++ + E L D L ++ +E +A+ + E
Sbjct: 1569 SKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERD---QLKENTKEIVAKMKESQE 1625
Query: 1543 R------LTSKLSTKDHKSEKD--QAGLEPLALRLSRELQEKEKVIEVLQAKLDA-RSLT 1593
+ +T+ T++ E + + E L L E ++ ++L L+ RS+T
Sbjct: 1626 KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVT 1685
Query: 1594 PSSSHALSDSHRSPSSTSFLS-DELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHS- 1651
D RS T + D+L+ I + EE K H +
Sbjct: 1686 KER-----DDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL 1740
Query: 1652 -AVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGF--HFHSIPKLASLPQ 1708
++S K + S Q K +SN +E AH +I KL +
Sbjct: 1741 RGIVSEKTNEISNMQ--KDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVS 1798
Query: 1709 APLPSAPSSFLPFSPTGPLL------LGCCETPVVSLA----EAQQ---ELQMLQKQLGE 1755
+ + L L E +++L E Q+ E++ L+KQ+ +
Sbjct: 1799 EKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKD 1858
Query: 1756 SASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMR 1815
+ T+ + L +L + N + S + L R+ E L + ++
Sbjct: 1859 QSLTL-----SKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQ 1913
Query: 1816 PQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRL-EESICIND------RL 1868
K DL + T L +EH + LR+++ E++I I+D +
Sbjct: 1914 ETKAR---DLEIQQEL------KTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKS 1964
Query: 1869 REQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQE 1928
+++L+ ++ + + + + NE L++ + V ++ Q
Sbjct: 1965 KDELQKKIQELQKKELQLLRV-KEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQL 2023
Query: 1929 TESLREALLSSR---SHLQELEKELEHQKVERQQLLEDLRE---KQQEVLHFREERLSLQ 1982
T+ L E+L R EL + E K+ER Q + LRE + ++ + E+ L
Sbjct: 2024 TKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLS 2083
Query: 1983 ENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSS 2042
+ QH L+++C ++L + YE L SLD +I
Sbjct: 2084 DGQ---QHLTESLREKCSRIKELLKRYSEMDDHYEC--------LNRLSLDLEKEIEFQK 2132
Query: 2043 DLS 2045
+LS
Sbjct: 2133 ELS 2135
Score = 76.6 bits (187), Expect = 3e-13
Identities = 166/837 (19%), Positives = 353/837 (42%), Gaps = 141/837 (16%)
Query: 8 LSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQ 67
LS DL+ N L+ +I L+ Q ++D+ + ++ E+E LK++++D+
Sbjct: 1804 LSNMQKDLENSNAKLQEKIQELKANEHQLITL-KKDVNETQKKVS-EMEQLKKQIKDQSL 1861
Query: 68 HLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMA 127
L K ++ENLN L ++ E +E + V + +N L+ K E ++
Sbjct: 1862 TLSKL--EIENLN------LAQKLHENLEEMKSVMKERDN----LRRVEETLKLERDQLK 1909
Query: 128 ALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQ-- 185
++ K +LE+ ++LK ++ + D+ E ++++ +I ++ + L
Sbjct: 1910 ESLQETKARDLEIQQELKTARMLSKE---HKETVDKLREKISEKTIQISDIQKDLDKSKD 1966
Query: 186 --ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAE 243
++ +++L +++ QLL + E+ +M + + E ++Q K ++ QSV + +
Sbjct: 1967 ELQKKIQELQKKELQLLRVKED-VNMSHKKINE--MEQLKKQFEAQNLSMQSVRMDNF-Q 2022
Query: 244 LQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEEL--- 300
L +K+ ++ +I+ ++ +E+ + + ++D I L+E + +R+R+ ++
Sbjct: 2023 LTKKLHESLEEIRIVAKERDELR---RIKESLKMERDQFIATLREMI-ARDRQNHQVKPE 2078
Query: 301 --------YQVIEGQNDTMAKLREML--------HQSQLGQLHSSEGTSPAQQQVALLDL 344
+ E + ++++E+L H L +L Q+ + +
Sbjct: 2079 KRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRV 2138
Query: 345 QSALFCSQLEIQKLQRVVRQKER----------QLADAKQCVQFVEAAAHESEQQKEASW 394
++ L L+ + ++++ +R +L V ++ HES + E +
Sbjct: 2139 KANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDF 2198
Query: 395 KHNQELRKAL----QQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLL 450
E +K L Q LQ++ S++LR + + ++ +E + S S +
Sbjct: 2199 IDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEIL---KDFSESEFPSIK 2255
Query: 451 QEFRELLQYRDNSDKTLEA---NEMLLEKLR---QRIHDKAVALERAIDEKFSALEEKEK 504
EF+++L R + LE +EKL+ Q+ +D+ + + + A+ +
Sbjct: 2256 TEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNEST 2315
Query: 505 ELRQLRLAV-RERDHDLERLRDVLSSNEATMQSMESLL--------------------RA 543
E + + +E + DL+ L++ Q++++ L RA
Sbjct: 2316 EFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRA 2375
Query: 544 KGLEVEQLSTTCQNLQWLKEEM---ETKFSRWQKEQE---SIIQQLQTSLHDRNKEVEDL 597
L E++ +L KE E+K + QKE E II +LQ +H+ NK +E
Sbjct: 2376 TQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKT 2435
Query: 598 SATLLC---KLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVST 654
T+ K+ G EE+ + L+ K L + ++ K E E EI +V
Sbjct: 2436 KETIQVLQDKVALGAKPYKEEI-EDLKMK---LVKIDLEKMKNAKEFEKEISATKATV-- 2489
Query: 655 REQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTD 714
E Q +L++ + R+ + Q S++S+ ++ Q P C G
Sbjct: 2490 ---EYQKEVIRLLRENLRRSQQAQDT--------SVISEH--TDPQPSNKPLTCGG---G 2533
Query: 715 QGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERE 771
G +Q ++ +L K + LEKE+S K++ E + K++ E
Sbjct: 2534 SGIVQ-----NTKALILKSEH-------------IRLEKEISKLKQQNEQLIKQKNE 2572
Score = 51.2 bits (121), Expect = 1e-05
Identities = 54/243 (22%), Positives = 115/243 (47%), Gaps = 23/243 (9%)
Query: 1842 DLLEEHLGE-IRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQL 1900
D L+E+L E I ++ EE ++ L+E E + + RG S ++ L
Sbjct: 1703 DQLKENLRETITRDLEKQEELKIVHMHLKEHQE----TIDKLRGIVSEKTNEISNMQKDL 1758
Query: 1901 CNENRVLREDNRRLQAQL--SHVSREHSQET-ESLREALLSSRSHLQELEKELEHQKVER 1957
+ N L+ + ++Q +L +H+ + QET + LR + L ++K+LE+ +
Sbjct: 1759 EHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKL 1818
Query: 1958 QQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSE-LQIY 2016
Q+ +++L+ + +++ +++ Q+ S ++ L++Q +++ L+ E L +
Sbjct: 1819 QEKIQELKANEHQLITLKKDVNETQKKVSEMEQ----LKKQIKDQSLTLSKLEIENLNLA 1874
Query: 2017 EALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRAL-RGQLEQSIQGNNCLRLQLQQQ 2075
+ L+ N L+ + D V E L R QL++S+Q L++QQ+
Sbjct: 1875 QKLHEN---------LEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQE 1925
Query: 2076 LES 2078
L++
Sbjct: 1926 LKT 1928
Score = 50.4 bits (119), Expect = 2e-05
Identities = 82/421 (19%), Positives = 177/421 (42%), Gaps = 32/421 (7%)
Query: 5 YRTLSQHLNDLKKENFSLKLRIYFLEE-RMQQKYEASREDIYKRNIE-LKVEVESLKREL 62
Y + H L + + L+ I F +E M+ K S + ++IE L + E
Sbjct: 2107 YSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEF 2166
Query: 63 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNE 122
+ L + V + + + + + E E ELL KIQ LQ++ + E
Sbjct: 2167 HRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLI-KIQHLQQDCDVPSRE 2225
Query: 123 AARMAALVEAEKECNLELSEKLKGVTKN--------WEDVPGDQVKPDQYTEALAQRDKR 174
+ + + +L + E LK +++ ++ V ++ + Q+ E
Sbjct: 2226 LRDL----KLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFD 2281
Query: 175 IEELNQSLAAQ-ERLVEQLSREKQQLLHLLEEPTSMEVQPMT-----EELLKQQKLNSHE 228
IE+L + + +R+ + + +++ ++ E T E + T E+ LK K + +
Sbjct: 2282 IEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEK 2341
Query: 229 TTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE 288
Q++ S + Q + N + + +++ E ++ + ++ KE
Sbjct: 2342 LFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLT------TEKIRELENSLHEAKE 2395
Query: 289 TLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSAL 348
+ +E + ++ + +E ND +AKL+ +H+S + E Q +VA L +
Sbjct: 2396 SAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVA---LGAKP 2452
Query: 349 FCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQ 408
+ ++E K+ ++V+ ++ +AK+ + + A E QKE + LR++ QQ Q
Sbjct: 2453 YKEEIEDLKM-KLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRS-QQAQ 2510
Query: 409 E 409
+
Sbjct: 2511 D 2511
Score = 40.4 bits (93), Expect = 0.021
Identities = 54/254 (21%), Positives = 105/254 (41%), Gaps = 25/254 (9%)
Query: 1856 QRLEESICIN-DRLREQLEHRLTSTARGRGSTSNFYSQGL--ESIPQLCNENRVLREDNR 1912
+R++E++ I D+L+E + + + F E+ ++C E L+E
Sbjct: 1596 KRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMC-EIEHLKEQFE 1654
Query: 1913 RLQAQLSHVSREHSQETESLREALLSSRSHLQE---LEKELEHQKVERQQLLEDLREKQQ 1969
+ L ++ E+ + T+ L E L RS +E L E KVER QL E+LRE
Sbjct: 1655 TQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETIT 1714
Query: 1970 EVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKA 2029
L +EE + + Q + L+ EK ++Q +L+ +S LKA
Sbjct: 1715 RDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLE-------HSNDALKA 1767
Query: 2030 YSLDACHQIPLS-----------SDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLES 2078
L ++ ++ L +V+E +++ ++ +N + Q+L++
Sbjct: 1768 QDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKA 1827
Query: 2079 GAGKASLSPSSINQ 2092
+ +N+
Sbjct: 1828 NEHQLITLKKDVNE 1841
Score = 37.4 bits (85), Expect = 0.17
Identities = 52/267 (19%), Positives = 109/267 (40%), Gaps = 29/267 (10%)
Query: 1849 GEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLR 1908
G+I +L++ L + + N+ LRE++ L S + S + + + I E ++
Sbjct: 720 GKITDLQKELNKEVEENEALREEVI--LLSELK---SLPSEVERLRKEIQDKSEELHIIT 774
Query: 1909 EDNRRLQAQLSHVSREHS---QETESLREALLSSRSHLQELEKELEHQKV-------ERQ 1958
+ +L +++ H +E ++ L +++S+ + ++E ++ K + +
Sbjct: 775 SEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYK 834
Query: 1959 QLLEDLREKQQEVLHFREE-----------RLSLQENDSRLQHKLVLLQQQCEEKQQLFE 2007
+LE+ QE+++ +E + L LQ K +Q++ E +QL E
Sbjct: 835 MVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKE 894
Query: 2008 SLQ---SELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQG 2064
L+ S LQ E + L+ + DL L ++ R QL+ I
Sbjct: 895 QLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHD 954
Query: 2065 NNCLRLQLQQQLESGAGKASLSPSSIN 2091
+ + Q+QL + +IN
Sbjct: 955 TVNMNIDTQEQLRNALESLKQHQETIN 981
Score = 32.3 bits (72), Expect = 5.6
Identities = 44/173 (25%), Positives = 77/173 (44%), Gaps = 9/173 (5%)
Query: 1891 SQGLE-SIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKE 1949
+Q LE S +L E VL E+ Q L +V +E S+ E++ E L + +
Sbjct: 1268 TQDLEKSHTKLQEEIPVLHEE----QELLPNV-KEVSETQETMNELELLTEQSTTKDSTT 1322
Query: 1950 LEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESL 2009
L ++ER +L E +E Q+E+ +ER +L+ L+ K L++ E +
Sbjct: 1323 LARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQES 1382
Query: 2010 QSELQIYEALYGNSKKGLKAYSLDACHQI-PLSSDLSHLVAEVRALRGQLEQS 2061
QS+ + ++L K + Q P S L + E+ L +L++S
Sbjct: 1383 QSKQE--QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQES 1433
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 145 bits (366), Expect = 5e-34
Identities = 245/1163 (21%), Positives = 490/1163 (42%), Gaps = 148/1163 (12%)
Query: 15 LKKENFSLKLRIYFLEERMQQKYEAS-------REDIYKRNIELKVEVESLKRELQDKKQ 67
L++E S KL+ +++Q +Y +S R ++ K E+ V V+ L++ +
Sbjct: 242 LERERESEKLKDEC--KKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNE 299
Query: 68 HLDKTWADVENL--NSQNEAELRRQFEERQQETEHVYELLENK-IQLLQEESRLAKNEAA 124
K ENL Q+ +L + E +++ L K + Q +SRL+ +E +
Sbjct: 300 LTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETS 359
Query: 125 RMAALVEAEK--ECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIE-ELNQS 181
VE + E +L E+L V ++ + + + Q E Q +++ E+NQ
Sbjct: 360 LHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL 419
Query: 182 LA-----------AQERLVEQLSREKQQLLHLLEEPTSMEVQ-PMTEELLKQQKLNSHET 229
+ A RL EQ ++L+ ++ ++++ EE LK++ NS E
Sbjct: 420 HSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTEL 479
Query: 230 TITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKET 289
H E Q Q T A + Q L ++ ++ + Q + +Q KE
Sbjct: 480 QHQLDKTKQQH-QEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKEN 538
Query: 290 LKSRERETEELY---QVIEGQNDTMAKLREMLH--QSQLGQL-----HSSEGTSPAQQQV 339
+ E+E E+LY Q EG+ + +L+E H Q Q+ QL + SE AQ+ +
Sbjct: 539 ISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENL 598
Query: 340 --ALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ----FVEAAAHESEQQKEAS 393
+ + ++ L +Q + L+ V + QL ++K+ V ++A + A
Sbjct: 599 HDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAK 658
Query: 394 WKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQ-EQNIQHLNHSLSHKEQL--- 449
+L+ L Q LQ+K Q+L N+I TQ +Q L H QL
Sbjct: 659 TAQRADLQNHLDTAQNALQDKQQEL--------NKITTQLDQVTAKLQDKQEHCSQLESH 710
Query: 450 LQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQL 509
L+E++E +Y KT E LE +++ ++ ++ + ++ L+++ + L
Sbjct: 711 LKEYKE--KYLSLEQKTEE-----LEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDL 763
Query: 510 RLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKF 569
L E LE ++++SS +Q L + ++L+ + Q LK++ ET
Sbjct: 764 ELRATELSKQLEMEKEIVSSTRLDLQKKSEALES---IKQKLTKQEEEKQILKQDFETLS 820
Query: 570 SRWQKEQESIIQQLQTSLHDRNK---EVEDLSATL------LCKLGPGQSEIAEELCQRL 620
+ + E + ++QT++ + K E E L L L K+ E +
Sbjct: 821 QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKEN 880
Query: 621 QRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQAL 680
Q+ + + DL ++ + L+H++++Q +++ ++E + + EK +A + EL ++
Sbjct: 881 QKGKAAILDL--EKTCKELKHQLQVQ--MENTLKEQKELKKSLEKEKEASHQLKLELNSM 936
Query: 681 RQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRS 740
++ L + + Q QQ + L + ++Q QI + + + +
Sbjct: 937 QEQLIQAQNTLKQNEKEEQQLQGN-INELKQSSEQKKKQIEALQGELKIAVLQKTELENK 995
Query: 741 TLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESL 800
L A +EL+ KE++ ++ +SQ LQS +E EL D++S+
Sbjct: 996 LQQQLTQAA---QELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 801 TRNIQI-KEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQE---ISGNRR 856
+ + +EDLI + + Q+ + + ++ L L + A E Q QE + +
Sbjct: 1053 EEKLSLAQEDLISN-RNQIGNQNKL--IQELKTAKATLEQDSAKKEQQLQERCKALQDIQ 1109
Query: 857 QQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSR 916
++ L + LV+E+S+L E + + + + K + +S + + ++ L+
Sbjct: 1110 KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEI-----TNLKDA 1164
Query: 917 LEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEK 976
+ ++ + LE + ++L A ++E+E +QQ++K ++K
Sbjct: 1165 KQLLIQQKLELQGKADSLKA-------------------AVEQE---KRNQQILKDQVKK 1202
Query: 977 SLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEK----RKAEEELKELKA 1032
L++E + A+ H ++EK +K EE +L
Sbjct: 1203 ---------------------EEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTM 1241
Query: 1033 QIEEAGFSSVSHIRNTMLSLCLENAELKEQ----MGEAMSDGWEIEEDKEKGEVMVETVV 1088
QI ++ ++ S +EL++Q GE ++ ++++ ++E +
Sbjct: 1242 QITALN-ENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCL 1300
Query: 1089 TKEGLSESSLQAEFRKLQGKLKN 1111
EG E LQ + +LQ KL N
Sbjct: 1301 KGEGEIE-KLQTKVLELQRKLDN 1322
Score = 128 bits (321), Expect = 8e-29
Identities = 251/1270 (19%), Positives = 513/1270 (40%), Gaps = 180/1270 (14%)
Query: 152 EDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLE------- 204
+D+ + Y+E L + ++ + L Q A + LV S E Q L LE
Sbjct: 93 QDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENF 152
Query: 205 ----------------------------------EPTSMEVQPMTEELLKQQKLNSHETT 230
E +V +TEEL K+ + T
Sbjct: 153 NIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKT 212
Query: 231 ITQQSVSDSHLAELQEKIQQTEA--TNKILQEKLNEMSYELKCAQESSQ--KQDGTIQNL 286
Q +A L++++ Q + N L+ + + +C + SQ + TI L
Sbjct: 213 ELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQL 272
Query: 287 KETLKSRERE----TEELYQVIEGQNDTMAK--------LREMLHQSQLGQLHSSEGTSP 334
+ L +E +EL ++ N+ K L++ ++L + H+ E S
Sbjct: 273 RSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSK 332
Query: 335 AQQQVAL----LD---LQSALFCSQLEIQKLQRVVRQK-------ERQLADAKQCVQFVE 380
Q L LD LQS L S+ + ++ + +K + +L++ + Q ++
Sbjct: 333 KNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLK 392
Query: 381 AAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLN 440
A + +QQ+E +H +L+ + QL +L +QL E + ++ Q Q +
Sbjct: 393 AEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQL----GEAHGRLKEQR---QLSS 445
Query: 441 HSLSHKEQLLQEFRELLQYRDN--SDKTLEANEM--LLEKLRQRIHDKAVALERAIDEKF 496
L KEQ + + + L + +K + E+ L+K +Q+ H + AL+++ K
Sbjct: 446 EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ-HQEQQALQQSTTAK- 503
Query: 497 SALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSME-------SLLRAKGLEVE 549
L E + +L Q+ + ++D ++ L +L ++ + +E + ++A E
Sbjct: 504 --LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETA 561
Query: 550 QLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKE-------VEDLSATLL 602
L+ + L+E++ T+ + K Q +Q Q +LHD+ +E +D +L
Sbjct: 562 VLNQLQEKNHTLQEQV-TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLE 620
Query: 603 CKLGPGQSEIAE--ELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQ 660
+ S++ E E +L + + +LL ++Q L + Q+ Q
Sbjct: 621 TSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ 680
Query: 661 AAAEKLVQALMERNSELQALRQYLGGRDSLMSQAP---ISNQQAEVTPTGCLGKQTDQGS 717
K+ L + ++LQ +++ +S + + +S +Q G + K+ + S
Sbjct: 681 QELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI-KKLEADS 739
Query: 718 MQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVA-GLEKELSNAKEELELMAKKERESQMEL 776
+++ + + A +D+ R DL+ A L K+L KE + ++ L
Sbjct: 740 LEVKASKEQ----ALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL 795
Query: 777 SALQSMMAVQEEELQVQAADMESLTRNIQIK-EDLIKDLQMQLVDPEDIP-AMERLTQEV 834
+++ + QEEE Q+ D E+L++ +I+ E+L +Q + + + + E L E+
Sbjct: 796 ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTEL 855
Query: 835 LLLREKVASV-----------ESQGQ----------EISGNRRQQLLLMLEGLVDERSRL 873
+++K++ V E + Q + + QL + +E + E+ L
Sbjct: 856 STVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKEL 915
Query: 874 NEALQAERQLYSSL-VKFHAHPES-SERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRL 931
++L+ E++ L ++ ++ E + TL+ + Q L+ + E+ S ++ ++
Sbjct: 916 KKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQI 975
Query: 932 ETLAAIGGAAAGDDTE---DTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSF 988
E L A TE + T + +E AA +++ EKS T + F
Sbjct: 976 EALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035
Query: 989 SPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNT 1048
G +S E+L R + E+ A+E+L + QI + ++
Sbjct: 1036 -----YGRES------ELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQN-KLIQELKTA 1083
Query: 1049 MLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGK 1108
+L ++A+ ++Q+ E +I+++K E KE ++E S AE +++ +
Sbjct: 1084 KATLEQDSAKKEQQLQERCKALQDIQKEKSLKE--------KELVNEKSKLAEIEEIKCR 1135
Query: 1109 LKNAHNIIN-LLKEQLVLSSKE-GNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEG 1166
+ +N LK + S KE N K +LL+ ++ L + + + ++
Sbjct: 1136 QEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQ- 1194
Query: 1167 NVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPG----PQSAFSLPGSTQHLRSQLSQ 1222
++ + + +L F +L ++ + ++ G ++ L L L
Sbjct: 1195 --ILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGT 1252
Query: 1223 CKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGR 1282
K+ +Q Q ++ +ELEK L GE V + + Q D + E C +
Sbjct: 1253 VKKEWQSSQRRV-----------SELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLK 1301
Query: 1283 SENEAEREET 1292
E E E+ +T
Sbjct: 1302 GEGEIEKLQT 1311
Score = 64.7 bits (156), Expect = 1e-09
Identities = 182/948 (19%), Positives = 377/948 (39%), Gaps = 125/948 (13%)
Query: 725 DSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNA-KEELE-LMAKKERESQMELSALQSM 782
+S ++DV++ R + DL EK S K+ELE +++E++ + S
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 783 MAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDP---------EDIPAMERLTQE 833
+Q E Q++ A E+ NI+ +DL + QL E+ E Q+
Sbjct: 135 AELQSLEQQLEEAQTENF--NIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQK 192
Query: 834 VLLLREKVASVESQGQEISGNRRQ---------------QLLLMLEGLVDERSRLNEALQ 878
V L E++ + Q++ Q Q+ +++ + ER R +E L+
Sbjct: 193 VTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLK 252
Query: 879 AE-RQLYSSLVKFHA-----HPESSERDRTLQVELEGAQVLRSRLEEVLGRS-------- 924
E ++L S A E ++ + + V ++ Q L+S + E+ ++
Sbjct: 253 DECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLL 312
Query: 925 --------LERLNRLETLAA--IGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVA- 973
LE + E+++ I D + + S E + H H +L +
Sbjct: 313 KKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGE 372
Query: 974 ----LEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKE 1029
L++ L+ VET+ ++ L L++E +Q + + E +L E
Sbjct: 373 ATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGE 432
Query: 1030 LKAQIEEAGFSSVSHIRNT---MLSLCLENAELKEQMGEAMSDGWEIEEDKEKG------ 1080
+++E S + + + L L+ + L+EQ+ E +++ E++ +K
Sbjct: 433 AHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQE 492
Query: 1081 -EVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELL 1139
+ + ++ K +++ L+ R++ K + N+ E L+ SKE S L E
Sbjct: 493 QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNL-----EALLQKSKENISLLEKERE 547
Query: 1140 -VHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAH-QLDNQSQ 1197
++ T ++ + H + VT + + H Q+ Q
Sbjct: 548 DLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKA 607
Query: 1198 PRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQ-------EKLLLSEATVFAQANELEK 1250
SL S L SQL++ K++ L E LL +EA AQ +L+
Sbjct: 608 HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQN 667
Query: 1251 YRVMLTGESLVK---QDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMV 1307
+ + T ++ ++ Q+ +I L + + + E+ ++ E E++ SL++
Sbjct: 668 H--LDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725
Query: 1308 L-MEGLCSEQGRRGSTLASSSERK----PLENQLGKQEEFRVYGKSENILVLRKDIKDLK 1362
+EG + + +S E+ + QL E R S+ + + ++ + +
Sbjct: 726 EELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTR 785
Query: 1363 AQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSD 1422
LQ ++ ++++K + L+ + L++ ++ + T + E+ L++
Sbjct: 786 LDLQKKSEALESIKQK---LTKQEEEKQILKQDFETLSQET-------KIQHEE---LNN 832
Query: 1423 GTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAE-ELRSASWPGKYDSL-IQD 1480
+ + K + E+L+ +S ++ +L K K ++ E + GK L ++
Sbjct: 833 RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK 892
Query: 1481 QARELSYLRQKIREGRGICYLITRHAKDTVKSFE-DLLRSNDIDYYLGQSFREQLAQGSQ 1539
+EL + Q E + K+ KS E + S+ + L S +EQL Q
Sbjct: 893 TCKELKHQLQVQMENT------LKEQKELKKSLEKEKEASHQLKLELN-SMQEQLIQAQN 945
Query: 1540 LTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKL 1587
++ +EK++ L+ L + ++K+K IE LQ +L
Sbjct: 946 TLKQ-----------NEKEEQQLQGNINELKQSSEQKKKQIEALQGEL 982
Score = 55.8 bits (133), Expect = 5e-07
Identities = 212/1163 (18%), Positives = 435/1163 (37%), Gaps = 204/1163 (17%)
Query: 995 GGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEEL-KELKAQIEEAGFSSVSHIR--NTMLS 1051
GG+SN L+ + + L + Q L+ K E+ +ELK ++E+ + +
Sbjct: 73 GGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTD 132
Query: 1052 LCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKN 1111
E L++Q+ EA ++ + I++ K+ E + T E ++ K
Sbjct: 133 SSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLAT-----------EIADIKSKYDE 181
Query: 1112 AHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVR 1171
++ ++++ ++E N + T I+ + TEL+ PG E+ V +
Sbjct: 182 ERSLREAAEQKVTRLTEELNKEAT---------VIQDLKTELLQRPGI----EDVAVLKK 228
Query: 1172 PFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQ 1231
+ Q+L +DN + R+ + + K + LQ
Sbjct: 229 ELVQVQTL------------MDNMTLERE-----------------RESEKLKDECKKLQ 259
Query: 1232 EKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREE 1291
+ SEAT+ +EL K + ++ Q+ ++++ + +L + +EN ++E+
Sbjct: 260 SQYASSEATISQLRSELAKGPQEV---AVYVQELQKLKSSVNELTQKNQTLTENLLKKEQ 316
Query: 1292 TTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENI 1351
+ E+HN E+ + ++ +K L+ Q Q + R+ ++
Sbjct: 317 DYTKLEEKHN-------------EESVSKKNIQATLHQKDLDCQ---QLQSRLSASETSL 360
Query: 1352 LVLRKDIKD-------LKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTL 1404
+ ++ + LK +L Q+LK+ + L + + +L++
Sbjct: 361 HRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKE--QHGLQLQS---- 414
Query: 1405 EGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEE 1464
E + HS E E L + G + + L Q+V+ L+ +L + LEE+L E+
Sbjct: 415 EINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSR--LEEQLKEK 472
Query: 1465 LRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDY 1524
+ +++ + +L +Q+ +E + + T ++ E +LR
Sbjct: 473 VTNST----------ELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR------ 516
Query: 1525 YLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQ 1584
++ KD K + +A L+ +S L EKE+ E L
Sbjct: 517 ----------------------QIGDKDQKIQNLEALLQKSKENIS--LLEKER--EDLY 550
Query: 1585 AKLDARSLTPSSSHALSD-SHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSD 1643
AK+ A + + L + +H + L+++L K S SH
Sbjct: 551 AKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKL-----------------KNQSESHKQ 593
Query: 1644 SIHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKL 1703
+ + H V K + A+Q ++ L + N KE + +L
Sbjct: 594 A-QENLHDQVQEQK-AHLRAAQDRVLSLETSVNELNSQLNESKE-----------KVSQL 640
Query: 1704 ASLPQAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGE-SASTVPP 1762
+A S+ + L +T +L + QQEL + QL + +A
Sbjct: 641 DIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDK 700
Query: 1763 ASTATLLSNDLEADSSYYLNSAQPHSPPRGTIEL--GRILEPGYLGSSGKWDVMRPQKGS 1820
+ L + L+ YL+ Q G I+ LE D+ + ++ +
Sbjct: 701 QEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLN 760
Query: 1821 VSGDLSSGSSVYQLNSKP-----TGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHR 1875
+L + QL + T DL ++ + +++Q+L + L++ E
Sbjct: 761 TDLELRATELSKQLEMEKEIVSSTRLDL-QKKSEALESIKQKLTKQEEEKQILKQDFETL 819
Query: 1876 LTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREA 1935
T +N + + ++ E L + ++ +LS VS +
Sbjct: 820 SQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKE 879
Query: 1936 LLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEV-----------------LHFREER 1978
++ + +LEK + K + Q +E+ ++Q+E+ L+ +E+
Sbjct: 880 NQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQ 939
Query: 1979 LSLQEN--------DSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAY 2030
L +N + +LQ + L+Q E+K++ E+LQ EL+I + L+
Sbjct: 940 LIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQ 999
Query: 2031 SLDACHQIPLSSD----LSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASLS 2086
A ++ + L + + + QL+ G L +Q L+S K SL+
Sbjct: 1000 LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLA 1059
Query: 2087 PSSINQNFPASTDPGNKQLLLQD 2109
+ N GN+ L+Q+
Sbjct: 1060 QEDLISN---RNQIGNQNKLIQE 1079
Score = 38.1 bits (87), Expect = 0.10
Identities = 52/249 (20%), Positives = 108/249 (43%), Gaps = 30/249 (12%)
Query: 1845 EEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNEN 1904
E+ +I L+ L+ ++ L +L+ +LT A+ + E I L N
Sbjct: 969 EQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEK-------EKISVLQNNY 1021
Query: 1905 RVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDL 1964
+E ++LQ+ + +E+E LL++R L+ +E++L + EDL
Sbjct: 1022 EKSQETFKQLQSDF------YGRESE-----LLATRQDLKSVEEKLSLAQ-------EDL 1063
Query: 1965 REKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSK 2024
+ ++ + + L+ + L+ +QQ +E+ + + +Q E + E N K
Sbjct: 1064 ISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEK 1123
Query: 2025 KGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQG-NNCLRLQLQQQLESGAGKA 2083
L C Q +++ L E+++ + + + I + +L +QQ+LE GKA
Sbjct: 1124 SKLAEIEEIKCRQ---EKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLEL-QGKA 1179
Query: 2084 SLSPSSINQ 2092
+++ Q
Sbjct: 1180 DSLKAAVEQ 1188
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 144 bits (363), Expect = 1e-33
Identities = 235/1157 (20%), Positives = 485/1157 (41%), Gaps = 143/1157 (12%)
Query: 4 GYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASR-EDIYKRNIELKVEVESLKREL 62
G R S L++L+KEN LK +++ +E M++ + + E++ + N+ L E +++
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDME--MERDMDRKKIEELMEENMTL----EMAQKQS 422
Query: 63 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQ---EESRLA 119
D+ HL + + +EA + E + T LE + Q L EE R
Sbjct: 423 MDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTT 482
Query: 120 KNEAARMAA-LVEAEKECNLELSEKLK----GVTKNWEDVPGDQVKPDQYTEALAQRDKR 174
+ A+ +++ EKE N LS+K++ + + + + Q + AQ +K
Sbjct: 483 VDSVEGNASKILKMEKE-NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKT 541
Query: 175 IEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQ 234
IE L ++ Q +++EQ + Q + L + + + + +++ K+ K+ T
Sbjct: 542 IETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSS 601
Query: 235 SVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLK---ETLK 291
+S + Q K + K E+ E+ EL ++ ++ I NLK E ++
Sbjct: 602 KLSKIEFEKRQIKKELEHYKEK--GERAEELENELHHLEKENELLQKKITNLKITCEKIE 659
Query: 292 SRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCS 351
+ E+E EL + T+ + + Q + + E + ++ + L +L C+
Sbjct: 660 ALEQENSELERENRKLKKTLDSFKNLTFQLESLE---KENSQLDEENLELRRNVESLKCA 716
Query: 352 QLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWK----HNQELRKALQQL 407
+++ +LQ ++ E + K+ ++ ++A+ ++E+ E S++ NQ L+K L+
Sbjct: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERL-EVSYQGLDIENQRLQKTLENS 775
Query: 408 QEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTL 467
+++Q +L+ E E +T ++N++ L S EQL +E + L + L
Sbjct: 776 NKKIQQLESELQDLEMEN----QTLQKNLEELKISSKRLEQLEKENKSL----EQETSQL 827
Query: 468 EANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVL 527
E ++ LEK +R+ +A + ++E + EKE + L + RL+++
Sbjct: 828 EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887
Query: 528 SSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSL 587
N + L++ ++++ L T ++L + E+++T QQ+ L
Sbjct: 888 KEN-------KELVKRATIDIKTLVTLREDL--VSEKLKT-------------QQMNNDL 925
Query: 588 HDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQG 647
E+E K+G + + + + ++L+ L K+ LE + E
Sbjct: 926 EKLTHELE--------KIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEE--- 974
Query: 648 LLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTG 707
+ ++ R +ES ++L Q L +AL+Q + S PIS
Sbjct: 975 KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISG--------- 1025
Query: 708 CLGKQTDQGSMQIPSRDDSTSLTAKED--VSIPRSTLGDLDTVAGLEKELSNAKEELELM 765
+ + S++ + L +D + + R+ A L+ E K +L+ +
Sbjct: 1026 ------EDNKWERESQETTRELLKVKDRLIEVERNN-------ATLQAEKQALKTQLKQL 1072
Query: 766 AKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIP 825
+ Q ++ ALQ Q LQ Q +++ +Q++ + L
Sbjct: 1073 ETQNNNLQAQILALQR----QTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSL------- 1121
Query: 826 AMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYS 885
+ Q LL ++ +S+E++ + + R+ L + + L+ + +L + + Y
Sbjct: 1122 ----MNQNAQLLIQQ-SSLENENESVI-KEREDLKSLYDSLIKDHEKLELLHERQASEYE 1175
Query: 886 SLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDD 945
SL+ H +S+ ++ L+VE + ++L + G+ LE L ++ + +
Sbjct: 1176 SLISKHGTLKSAHKN--LEVEHRDLEDRYNQLLKQKGQ-LEDLEKMLKVEQEKMLLENKN 1232
Query: 946 TEDTSTEFTDSI-EEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQE 1004
E + E+ E + +H++ QL+K + L T S S +
Sbjct: 1233 HETVAAEYKKLCGENDRLNHTYSQLLKET--EVLQTDHKNLKSLLNNSKL---------- 1280
Query: 1005 EMLHLRAEFHQHLEEKRKAE----------EELKELKAQIEEAGFSSVSHIRNTMLSLCL 1054
E L AEF + E+ ++ + E L +LK +EE H+ + + +L L
Sbjct: 1281 EQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN----RHLLDQIQTLML 1336
Query: 1055 ENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHN 1114
+N L EQ E+ D + +E+ ++ + + E KE L E + + N
Sbjct: 1337 QNRTLLEQNMES-KDLFHVEQ-RQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGN 1394
Query: 1115 IINLLKEQLVLSSKEGN 1131
I L +L+ S K+ N
Sbjct: 1395 WITLKMRKLIKSKKDIN 1411
Score = 123 bits (309), Expect = 2e-27
Identities = 260/1236 (21%), Positives = 499/1236 (40%), Gaps = 179/1236 (14%)
Query: 35 QKYEASREDIYKRNIELKVEVESLKRELQDKKQHL---------DKTWADVENLNSQNEA 85
QK E E I + + K V + +E+ ++++ D + D+E L
Sbjct: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMAL 195
Query: 86 ELRRQFEERQQETEHVYELLENK--IQLLQEESRLAKNEAARMA-ALVEAEKECNLELSE 142
L+R +ER + +E + EL E + + L S A++ E+ + ++EL++
Sbjct: 196 HLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELAD 255
Query: 143 ---KLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLS------ 193
K++ + + E+ + Q E + KR+++ N +L + R
Sbjct: 256 AKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL 315
Query: 194 REKQQLLHLLEEPTSMEVQPM---------TEELLKQQKLNSHETTITQQSVSDSHLAEL 244
REK + LE S + + EEL + ++ T+ + + +
Sbjct: 316 REKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRAR-- 373
Query: 245 QEKIQQTEATNKILQEKLNEMSYE-----------------LKCAQESSQKQD----GTI 283
+K+ + E N L+ KL++M E L+ AQ+ S + +
Sbjct: 374 SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWEL 433
Query: 284 QNLKETLKSRERETEEL-YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALL 342
+ + T + E + L ++V E + + KL EM +QS + T + + A
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKL-EMENQSLTKTVEELRTTVDSVEGNA-- 490
Query: 343 DLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ------------------FVEAAAH 384
S + + E Q+L + V E ++ KQ +Q +E
Sbjct: 491 ---SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 385 ESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS 444
SE+Q + + N+ L + + L++ Q S + R + EK N+I ++I+ + LS
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQ-ISAEARVKDIEKENKI--LHESIKETSSKLS 604
Query: 445 HKE-QLLQEFRELLQYRDNSDKTLEANEML--LEKLRQRIHDKAVALERAIDEKFSALEE 501
E + Q +EL Y++ ++ E L LEK + + K L + EK ALE+
Sbjct: 605 KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL-KITCEKIEALEQ 663
Query: 502 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQ--LSTTCQNLQ 559
+ EL + +++ + L L S ++ S L + LE+ + S C +++
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLES----LEKENSQLDEENLELRRNVESLKCASMK 719
Query: 560 WLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQR 619
+ ++E KE ES +QL+ L L K ++E E Q
Sbjct: 720 MAQLQLE------NKELESEKEQLKKGLE-------------LLKASFKKTERLEVSYQG 760
Query: 620 LQRKERMLQDLLSDRNKQVLEHEMEIQGL---LQSVSTREQESQAAAEKLVQALMERNSE 676
L + + LQ L + NK++ + E E+Q L Q++ +E + ++++L Q E S
Sbjct: 761 LDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSL 820
Query: 677 LQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVS 736
Q Q + L + QQAE+ T G+++ ++ T +++
Sbjct: 821 EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK------TLSKEIG 874
Query: 737 IPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAAD 796
I + + L KEL +EL K+ L L+ + ++ + Q D
Sbjct: 875 IYKESCVRL-------KELEKENKEL---VKRATIDIKTLVTLREDLVSEKLKTQQMNND 924
Query: 797 MESLTRNIQ----IKEDLIKDLQMQLVDPEDIPAMERLTQEVL-----LLREKVASVESQ 847
+E LT ++ KE L+ D Q D +E + L + EK+A++E++
Sbjct: 925 LEKLTHELEKIGLNKERLLHD--EQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEAR 982
Query: 848 GQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLV------KFHAHPESSER-- 899
+E S N QQL L+ + L + ER + SS K+ + + R
Sbjct: 983 LEE-STNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTREL 1041
Query: 900 ----DRTLQVELEGA------QVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDT 949
DR ++VE A Q L+++L+++ + N + A+ ++T
Sbjct: 1042 LKVKDRLIEVERNNATLQAEKQALKTQLKQL---ETQNNNLQAQILALQRQTVSLQEQNT 1098
Query: 950 STEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHL 1009
+ + ++ Q+ L ++ QN + N + +E L
Sbjct: 1099 TLQ---------TQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL 1149
Query: 1010 RAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSD 1069
++ + +++ K E L E +A E+ S +++ +L +E+ +L+++ + +
Sbjct: 1150 KSLYDSLIKDHEKL-ELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQ 1208
Query: 1070 GWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNA-HNIINLLKEQLVLSSK 1128
++ ED EK + + + E + ++ AE++KL G+ H LLKE VL +
Sbjct: 1209 KGQL-EDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTD 1267
Query: 1129 EGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQE 1164
N K LL + S +E+ E S K Q+Q+
Sbjct: 1268 HKNLK---SLLNN--SKLEQTRLEAEFSKLKEQYQQ 1298
Score = 101 bits (251), Expect = 1e-20
Identities = 300/1488 (20%), Positives = 596/1488 (40%), Gaps = 208/1488 (13%)
Query: 285 NLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDL 344
+LK + R+ +E + ++ E ++ L + H S Q S G+ ++ + L
Sbjct: 196 HLKRLIDERDEHSETIIELSEERDG----LHFLPHASSSAQ--SPCGSPGMKRTESRQHL 249
Query: 345 QSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKAL 404
L ++ +I++L++ + +K QL D KQ ++ +E +Q+ + R
Sbjct: 250 SVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR 309
Query: 405 QQLQEELQNKSQQLRAWEAE--KYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ---- 458
+L + L+ K+ ++ E+E +Y E + + L Q+L E + +L+
Sbjct: 310 DEL-DALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLE 368
Query: 459 -YRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD 517
R SDK E + L+ L+ ++HD + +ER +D K +EE +E L +A ++
Sbjct: 369 GTRARSDKLHELEKENLQ-LKAKLHD--MEMERDMDRK--KIEELMEENMTLEMAQKQSM 423
Query: 518 HDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTC--------QNLQWLKEEMETKF 569
+ L L T + E+ ++ G EV +L+++ Q+L EE+ T
Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTV 483
Query: 570 SRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQS--EIAEELCQRLQRKERML 627
+ I++ ++ +K+VE L ++ + Q+ ++++L + + E+ +
Sbjct: 484 DSVEGNASKILK-MEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542
Query: 628 QDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGR 687
+ L + +Q+ E E + L Q+VS+ Q SQ +AE V+ + + N + L + +
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN---KILHESIKET 599
Query: 688 DSLMSQAPISNQQA--EVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDL 745
S +S+ +Q E+ G++ ++ ++ + L K+ ++ +
Sbjct: 600 SSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITC---- 655
Query: 746 DTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQ 805
+ + LE+E S + E + KK +S L+ + ++++E Q+ ++E L RN++
Sbjct: 656 EKIEALEQENSELERENRKL-KKTLDSFKNLTF--QLESLEKENSQLDEENLE-LRRNVE 711
Query: 806 -IKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVES-----QGQEISGNRRQQL 859
+K +K Q+QL + E E+L + + LL+ E QG +I R Q+
Sbjct: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771
Query: 860 L-------LMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQV 912
L LE + + N+ LQ + L + + + +++L+ E +
Sbjct: 772 LENSNKKIQQLESELQDLEMENQTLQ--KNLEELKISSKRLEQLEKENKSLEQETSQLEK 829
Query: 913 LRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTD-------SIEEEAAHHS 965
+ +LE+ R ++ +T G+ ++ T + + +
Sbjct: 830 DKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE 889
Query: 966 HQQLVKVALE--KSLATVETQNPSFS-PPSPMGGDSNRCLQE-EMLHLRAEFHQH----- 1016
+++LVK A K+L T+ S M D + E E + L E H
Sbjct: 890 NKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949
Query: 1017 -------LEEKRKA---------EEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELK 1060
LE K ++ EE++ L+A++EE+ + +R + ++ LK
Sbjct: 950 DDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYN-QQLRQELKTVKKNYEALK 1008
Query: 1061 EQMGEAMS-------DGWEIEEDKEKGEVMVETVVTKEGLSE-----SSLQAEFRKLQGK 1108
++ E G + + ++E E E + K+ L E ++LQAE + L+ +
Sbjct: 1009 QRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ 1068
Query: 1109 LKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNV 1168
LK N L+ Q++ ++ T +++ NT L K Q + N
Sbjct: 1069 LKQLETQNNNLQAQILALQRQ-------------TVSLQEQNTTLQTQNAKLQVE---NS 1112
Query: 1169 TVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQ 1228
T+ ++ A + L+N+++ + SL S +L +R
Sbjct: 1113 TLNS-QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQA 1171
Query: 1229 DLQEKLLLSEATVFAQANELE--------KYRVMLTGESLVKQDSKQIQVDLQDLGYETC 1280
E L+ T+ + LE +Y +L + ++ K ++V+ + + E
Sbjct: 1172 SEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLEN- 1230
Query: 1281 GRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQE 1340
+ ET + E ++ LC E R T + QL K+
Sbjct: 1231 -------KNHETVAAEYKK------------LCGENDRLNHTYS----------QLLKET 1261
Query: 1341 EFRVYGKSENILVLRKDIKDLKAQLQNAN-------KVIQNLKSRVRSLSVTSD-YSSSL 1392
E VL+ D K+LK+ L N+ LK + + L +TS ++
Sbjct: 1262 E-----------VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQC 1310
Query: 1393 ERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKK----DLESLIQRVSQL 1448
E +L+ G LE + H + L + T +++K + I ++++L
Sbjct: 1311 ELLSQLK--GNLEEENRHLLDQIQTLMLQNRT--LLEQNMESKDLFHVEQRQYIDKLNEL 1366
Query: 1449 EAQLPKNGLEEKLAEELR--SASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHA 1506
Q K LEEK+ ++ + S P + + I + R+L ++ I R +T
Sbjct: 1367 RRQ--KEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTR 1424
Query: 1507 KDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLA 1566
D+ + F L Q ++ + GS E L TK + D LA
Sbjct: 1425 SDSSEGFLQLPH---------QDSQDSSSVGSNSLED-GQTLGTKKSSTMNDLVQSMVLA 1474
Query: 1567 LRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIV 1626
+ + + E ++ K + S + SS F S +L D
Sbjct: 1475 GQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDT--- 1531
Query: 1627 SEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAESNSN 1674
T +E+ DS S+ S V +S+P+S + + + + SN+N
Sbjct: 1532 ---TSFEDISPQGVSDDS---STGSRVHASRPASLDSGRTSTSNSNNN 1573
Score = 43.9 bits (102), Expect = 0.002
Identities = 60/263 (22%), Positives = 112/263 (42%), Gaps = 39/263 (14%)
Query: 1839 TGADLLEEHLGEIRNLR---QRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLE 1895
T D +E + +I + QRL + + E LE+ + + + N ++
Sbjct: 481 TTVDSVEGNASKILKMEKENQRLSKKV-------EILENEIVQEKQSLQNCQNLSKDLMK 533
Query: 1896 SIPQLCNENRVLREDNRRLQAQLSHVSREHSQET-ESLRE-ALLSSRSHLQELEKE---- 1949
QL LRE++ R Q ++ EH +T SLR+ + +S+ + ++++EKE
Sbjct: 534 EKAQLEKTIETLRENSER-QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKIL 592
Query: 1950 -------------LEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQ 1996
+E +K + ++ LE +EK + E L++ + LQ K+ L+
Sbjct: 593 HESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLK 652
Query: 1997 QQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRG 2056
CE+ E+L+ E E KK L ++ L + S L E LR
Sbjct: 653 ITCEK----IEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELR- 707
Query: 2057 QLEQSIQGNNCLRLQLQQ-QLES 2078
++++ C +++ Q QLE+
Sbjct: 708 ---RNVESLKCASMKMAQLQLEN 727
Score = 42.7 bits (99), Expect = 0.004
Identities = 73/324 (22%), Positives = 134/324 (41%), Gaps = 63/324 (19%)
Query: 1844 LEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNF------YSQGLESI 1897
LE+ ++ +++LE+ N RLR+Q E + T+ N S+ +
Sbjct: 820 LEQETSQLEKDKKQLEKE---NKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIY 876
Query: 1898 PQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSR-------SHLQELEKEL 1950
+ C + L ++N+ L + + + +LRE L+S + + L++L EL
Sbjct: 877 KESCVRLKELEKENKELVKRATI----DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL 932
Query: 1951 EHQKVERQQLLEDLREKQQEVLHFREERL--SLQENDSRLQHKLVLLQQQCEEK----QQ 2004
E + +++LL D + E +L +L+++ + K+ L+ + EE QQ
Sbjct: 933 EKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 992
Query: 2005 LFESLQSELQIYEALYGNSKKGLKAYSLDAC-----------------------HQIPLS 2041
L + L++ + YEAL + S I +
Sbjct: 993 LRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVE 1052
Query: 2042 SDLSHLVAEVRALRGQLEQSIQGNNCLRLQ----------LQQQ---LESGAGKASLSPS 2088
+ + L AE +AL+ QL+Q NN L+ Q LQ+Q L++ K + S
Sbjct: 1053 RNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENS 1112
Query: 2089 SINQNFPASTDPGNKQLLLQDSAV 2112
++N S N QLL+Q S++
Sbjct: 1113 TLNSQ-STSLMNQNAQLLIQQSSL 1135
Score = 38.9 bits (89), Expect = 0.060
Identities = 53/249 (21%), Positives = 110/249 (44%), Gaps = 28/249 (11%)
Query: 1832 YQLNS-KPTGADLLEEHLGEIRNLRQRLEESICINDRLRE-QLEHR-LTSTARGRGSTSN 1888
+QL S + + L EE+L LR+ +E C + ++ + QLE++ L S
Sbjct: 687 FQLESLEKENSQLDEENL----ELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLE 742
Query: 1889 FYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEK 1948
+ +L + L +N+RLQ L + +++ Q L++ + + Q L+K
Sbjct: 743 LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN----QTLQK 798
Query: 1949 ELEHQKVER---QQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEK--- 2002
LE K+ +QL ++ + +QE +++ L++ + RL+ + + EE
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858
Query: 2003 ----QQLFESLQSELQIY-------EALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEV 2051
++ ++L E+ IY + L +K+ +K ++D + L DL +
Sbjct: 859 IGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKT 918
Query: 2052 RALRGQLEQ 2060
+ + LE+
Sbjct: 919 QQMNNDLEK 927
Score = 34.3 bits (77), Expect = 1.5
Identities = 45/197 (22%), Positives = 87/197 (44%), Gaps = 38/197 (19%)
Query: 1897 IPQLCNENRVLREDNRRLQAQL----SHVSREHSQETESLREALLSSRSHLQELEKELEH 1952
+ +L +N+VL E L+ QL + + H E E+L+ L ++ H E+E++++
Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ---LKAKLHDMEMERDMDR 402
Query: 1953 QKVE---RQQLLEDLREKQ--QEVLH--FREERLSLQENDSRLQHKLV-----------L 1994
+K+E + + ++ +KQ E LH + E++S S K + L
Sbjct: 403 KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRL 462
Query: 1995 LQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRAL 2054
L+ + E Q L ++++ +++ GN+ K LK + + L +V L
Sbjct: 463 LKLEM-ENQSLTKTVEELRTTVDSVEGNASKILK-----------MEKENQRLSKKVEIL 510
Query: 2055 RGQLEQSIQG-NNCLRL 2070
++ Q Q NC L
Sbjct: 511 ENEIVQEKQSLQNCQNL 527
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 143 bits (361), Expect = 2e-33
Identities = 236/1157 (20%), Positives = 486/1157 (42%), Gaps = 144/1157 (12%)
Query: 4 GYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASR-EDIYKRNIELKVEVESLKREL 62
G R S L++L+KEN LK +++ +E M++ + + E++ + N+ L E +++
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDME--MERDMDRKKIEELMEENMTL----EMAQKQS 422
Query: 63 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQ---EESRLA 119
D+ HL + + +EA + E + T LE + Q L EE R
Sbjct: 423 MDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTT 482
Query: 120 KNEAARMAA-LVEAEKECNLELSEKLK----GVTKNWEDVPGDQVKPDQYTEALAQRDKR 174
+ A+ +++ EKE N LS+K++ + + + + Q + AQ +K
Sbjct: 483 VDSVEGNASKILKMEKE-NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKT 541
Query: 175 IEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQ 234
IE L ++ Q +++EQ + Q + L + + + + +++ K+ K+ T
Sbjct: 542 IETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSS 601
Query: 235 SVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLK---ETLK 291
+S + Q K + K E+ E+ EL ++ ++ I NLK E ++
Sbjct: 602 KLSKIEFEKRQIKKELEHYKEK--GERAEELENELHHLEKENELLQKKITNLKITCEKIE 659
Query: 292 SRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCS 351
+ E+E EL + T+ + + Q + + E + ++ + L +L C+
Sbjct: 660 ALEQENSELERENRKLKKTLDSFKNLTFQLESLE---KENSQLDEENLELRRNVESLKCA 716
Query: 352 QLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWK----HNQELRKALQQL 407
+++ +LQ ++ E + K+ ++ ++A+ ++E+ E S++ NQ L+K L+
Sbjct: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERL-EVSYQGLDIENQRLQKTLENS 775
Query: 408 QEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTL 467
+++Q +L+ E E +T ++N++ L S EQL +E + L + L
Sbjct: 776 NKKIQQLESELQDLEMEN----QTLQKNLEELKISSKRLEQLEKENKSL----EQETSQL 827
Query: 468 EANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVL 527
E ++ LEK +R+ +A + ++E + EKE + L + RL+++
Sbjct: 828 EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887
Query: 528 SSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSL 587
N + L++ ++++ L T ++L + E+++T QQ+ L
Sbjct: 888 KEN-------KELVKRATIDIKTLVTLREDL--VSEKLKT-------------QQMNNDL 925
Query: 588 HDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQG 647
E+E K+G + + + Q + ++L+ L K+ LE + E
Sbjct: 926 EKLTHELE--------KIGLNKERLLHDE-QSTDDRYKLLESKLESTLKKSLEIKEE--- 973
Query: 648 LLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTG 707
+ ++ R +ES ++L Q L +AL+Q + S PIS
Sbjct: 974 KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISG--------- 1024
Query: 708 CLGKQTDQGSMQIPSRDDSTSLTAKED--VSIPRSTLGDLDTVAGLEKELSNAKEELELM 765
+ + S++ + L +D + + R+ A L+ E K +L+ +
Sbjct: 1025 ------EDNKWERESQETTRELLKVKDRLIEVERNN-------ATLQAEKQALKTQLKQL 1071
Query: 766 AKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIP 825
+ Q ++ ALQ Q LQ Q +++ +Q++ + L
Sbjct: 1072 ETQNNNLQAQILALQR----QTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSL------- 1120
Query: 826 AMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYS 885
+ Q LL ++ +S+E++ + + R+ L + + L+ + +L + + Y
Sbjct: 1121 ----MNQNAQLLIQQ-SSLENENESVI-KEREDLKSLYDSLIKDHEKLELLHERQASEYE 1174
Query: 886 SLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDD 945
SL+ H +S+ ++ L+VE + ++L + G+ LE L ++ + +
Sbjct: 1175 SLISKHGTLKSAHKN--LEVEHRDLEDRYNQLLKQKGQ-LEDLEKMLKVEQEKMLLENKN 1231
Query: 946 TEDTSTEFTDSI-EEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQE 1004
E + E+ E + +H++ QL+K + L T S S +
Sbjct: 1232 HETVAAEYKKLCGENDRLNHTYSQLLKET--EVLQTDHKNLKSLLNNSKL---------- 1279
Query: 1005 EMLHLRAEFHQHLEEKRKAE----------EELKELKAQIEEAGFSSVSHIRNTMLSLCL 1054
E L AEF + E+ ++ + E L +LK +EE H+ + + +L L
Sbjct: 1280 EQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN----RHLLDQIQTLML 1335
Query: 1055 ENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHN 1114
+N L EQ E+ D + +E+ ++ + + E KE L E + + N
Sbjct: 1336 QNRTLLEQNMES-KDLFHVEQ-RQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGN 1393
Query: 1115 IINLLKEQLVLSSKEGN 1131
I L +L+ S K+ N
Sbjct: 1394 WITLKMRKLIKSKKDIN 1410
Score = 122 bits (305), Expect = 5e-27
Identities = 259/1236 (20%), Positives = 502/1236 (40%), Gaps = 180/1236 (14%)
Query: 35 QKYEASREDIYKRNIELKVEVESLKRELQDKKQHL---------DKTWADVENLNSQNEA 85
QK E E I + + K V + +E+ ++++ D + D+E L
Sbjct: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMAL 195
Query: 86 ELRRQFEERQQETEHVYELLENK--IQLLQEESRLAKNEAARMA-ALVEAEKECNLELSE 142
L+R +ER + +E + EL E + + L S A++ E+ + ++EL++
Sbjct: 196 HLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELAD 255
Query: 143 ---KLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLS------ 193
K++ + + E+ + Q E + KR+++ N +L + R
Sbjct: 256 AKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL 315
Query: 194 REKQQLLHLLEEPTSMEVQPM---------TEELLKQQKLNSHETTITQQSVSDSHLAEL 244
REK + LE S + + EEL + ++ T+ + + +
Sbjct: 316 REKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRAR-- 373
Query: 245 QEKIQQTEATNKILQEKLNEMSYE-----------------LKCAQESSQKQD----GTI 283
+K+ + E N L+ KL++M E L+ AQ+ S + +
Sbjct: 374 SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWEL 433
Query: 284 QNLKETLKSRERETEEL-YQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALL 342
+ + T + E + L ++V E + + KL EM +QS + T + + A
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKL-EMENQSLTKTVEELRTTVDSVEGNA-- 490
Query: 343 DLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ------------------FVEAAAH 384
S + + E Q+L + V E ++ KQ +Q +E
Sbjct: 491 ---SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 385 ESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS 444
SE+Q + + N+ L + + L++ Q S + R + EK N+I ++I+ + LS
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQ-ISAEARVKDIEKENKI--LHESIKETSSKLS 604
Query: 445 HKE-QLLQEFRELLQYRDNSDKTLEANEML--LEKLRQRIHDKAVALERAIDEKFSALEE 501
E + Q +EL Y++ ++ E L LEK + + K L + EK ALE+
Sbjct: 605 KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL-KITCEKIEALEQ 663
Query: 502 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQ--LSTTCQNLQ 559
+ EL + +++ + L L S ++ S L + LE+ + S C +++
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLES----LEKENSQLDEENLELRRNVESLKCASMK 719
Query: 560 WLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQR 619
+ ++E KE ES +QL+ L L K ++E E Q
Sbjct: 720 MAQLQLE------NKELESEKEQLKKGLE-------------LLKASFKKTERLEVSYQG 760
Query: 620 LQRKERMLQDLLSDRNKQVLEHEMEIQGL---LQSVSTREQESQAAAEKLVQALMERNSE 676
L + + LQ L + NK++ + E E+Q L Q++ +E + ++++L Q E S
Sbjct: 761 LDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSL 820
Query: 677 LQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVS 736
Q Q + L + QQAE+ T G+++ ++ T +++
Sbjct: 821 EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK------TLSKEIG 874
Query: 737 IPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAAD 796
I + + L KEL +EL K+ L L+ + ++ + Q D
Sbjct: 875 IYKESCVRL-------KELEKENKEL---VKRATIDIKTLVTLREDLVSEKLKTQQMNND 924
Query: 797 MESLTRNIQ----IKEDLIKDLQ-----MQLVDPEDIPAMERLTQEVLLLREKVASVESQ 847
+E LT ++ KE L+ D Q +L++ + L + + + EK+A++E++
Sbjct: 925 LEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESK---LESTLKKSLEIKEEKIAALEAR 981
Query: 848 GQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLV------KFHAHPESSER-- 899
+E S N QQL L+ + L + ER + SS K+ + + R
Sbjct: 982 LEE-STNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTREL 1040
Query: 900 ----DRTLQVELEGA------QVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDT 949
DR ++VE A Q L+++L+++ + N + A+ ++T
Sbjct: 1041 LKVKDRLIEVERNNATLQAEKQALKTQLKQL---ETQNNNLQAQILALQRQTVSLQEQNT 1097
Query: 950 STEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHL 1009
+ + ++ Q+ L ++ QN + N + +E L
Sbjct: 1098 TLQ---------TQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL 1148
Query: 1010 RAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSD 1069
++ + +++ K E L E +A E+ S +++ +L +E+ +L+++ + +
Sbjct: 1149 KSLYDSLIKDHEKL-ELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQ 1207
Query: 1070 GWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNA-HNIINLLKEQLVLSSK 1128
++ ED EK + + + E + ++ AE++KL G+ H LLKE VL +
Sbjct: 1208 KGQL-EDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTD 1266
Query: 1129 EGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQE 1164
N K LL + S +E+ E S K Q+Q+
Sbjct: 1267 HKNLK---SLLNN--SKLEQTRLEAEFSKLKEQYQQ 1297
Score = 88.2 bits (217), Expect = 9e-17
Identities = 253/1247 (20%), Positives = 498/1247 (39%), Gaps = 217/1247 (17%)
Query: 295 RETEELYQVIEGQN-DTMAK----LREMLH-QSQLGQLHSSEGTSPAQQQVALLDLQSAL 348
++ EE + I+G + DT A ++E+ H Q + L E T +Q+ + L AL
Sbjct: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMAL 195
Query: 349 FCSQLEIQKLQRVVRQKER------QLADAKQCVQFVEAAAHESEQQKEASWKHNQELRK 402
L+R++ +++ +L++ + + F+ A+ ++ + E R+
Sbjct: 196 H--------LKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQ 247
Query: 403 ALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQ----LLQEFRELLQ 458
L + + K ++LR EK ++ +Q ++ + L +Q LL + R
Sbjct: 248 HLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARM 307
Query: 459 YRDNSDKTLEAN------EMLLEKLRQRIHD---KAVALERAIDEKFSALEEK---EKEL 506
YRD D E E + + ++R+HD +E ++ LE K E +L
Sbjct: 308 YRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQL 367
Query: 507 RQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEM- 565
R A ++ H+LE+ L + M+ + R K E+ + + T + Q K+ M
Sbjct: 368 EGTR-ARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ--KQSMD 424
Query: 566 ETKFSRWQKEQESIIQQL-QTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKE 624
E+ W+ EQ S +L + EV +L+++ L KL E+ + + +
Sbjct: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKL-----EMENQSLTKTVEEL 479
Query: 625 RMLQDLLSDRNKQVLEHEMEIQGLLQSVS------TREQESQAAAEKLVQALMERNSELQ 678
R D + ++L+ E E Q L + V +E++S + L + LM+ ++L+
Sbjct: 480 RTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLE 539
Query: 679 ALRQYLGGRDSLMSQAPISNQQAE-VTPTGCLGKQTDQGSMQIPSRD-DSTSLTAKEDVS 736
+ L R++ Q I Q+ E + T +Q Q S + +D + + E +
Sbjct: 540 KTIETL--RENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 597
Query: 737 IPRSTLGDLD-TVAGLEKELSNAKE----------ELELMAKKERESQMELSALQSMMAV 785
S L ++ ++KEL + KE EL + K+ Q +++ L+ +
Sbjct: 598 ETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLK-ITCE 656
Query: 786 QEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVE 845
+ E L+ + +++E R ++ D K+L QL E +L +E L LR V S++
Sbjct: 657 KIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEK--ENSQLDEENLELRRNVESLK 714
Query: 846 SQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQV 905
+++ QL L + L E+ +L + L+ L+K S ++ L+V
Sbjct: 715 CASMKMA-----QLQLENKELESEKEQLKKGLE--------LLK-----ASFKKTERLEV 756
Query: 906 ELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHS 965
+G + RL+ ++LE N+ + +E D E
Sbjct: 757 SYQGLDIENQRLQ----KTLENSNK--------------KIQQLESELQDLEMENQTLQK 798
Query: 966 HQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEE 1025
+ + +K++ K L +E +N S L++E L + Q LE++ K
Sbjct: 799 NLEELKIS-SKRLEQLEKENKS--------------LEQETSQLEKDKKQ-LEKENKRLR 842
Query: 1026 ELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVE 1085
+ E+K E + ++ +L E KE E +E ++ + ++
Sbjct: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
Query: 1086 TVVT------KEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELL 1139
T+VT E L + + KL +L+ I L KE+ +L ++ L
Sbjct: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHELEK----IGLNKER-LLHDEQSTDDRYKLLE 957
Query: 1140 VHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPR 1199
L ST++ K +E + +S +
Sbjct: 958 SKLESTLK-----------KSLEIKEEKIAALEARLEESTNYN----------------- 989
Query: 1200 DPGPQSAFSLPGSTQHLRSQLSQCKQRYQDL-----QEKLLLSEATVFAQANELEKYRVM 1254
Q LR +L K+ Y+ L +E+++ S + + N+ E+
Sbjct: 990 --------------QQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQE 1035
Query: 1255 LTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCS 1314
T E L+K + I+V+ + + +E +A + + E + +N +++ ++
Sbjct: 1036 TTRE-LLKVKDRLIEVERNNATLQ----AEKQALKTQLKQLETQNNNLQAQILALQRQTV 1090
Query: 1315 EQGRRGSTLASSSERKPLENQ-LGKQ-------------EEFRVYGKSENILVLRKDIKD 1360
+ +TL + + + +EN L Q ++ + ++E+++ R+D+K
Sbjct: 1091 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1150
Query: 1361 LKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWL 1420
L L ++ ++ L R S+Y S + + GTL+ S H + + L
Sbjct: 1151 LYDSLIKDHEKLELLHER-----QASEYESLISKH------GTLK--SAHKNLEVEHRDL 1197
Query: 1421 SDGTGAFYSPGLQAKKDLESLIQRVS-QLEAQLPKNGLEEKLAEELR 1466
D Y+ L+ K LE L + + + E L +N E +A E +
Sbjct: 1198 EDR----YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYK 1240
Score = 43.9 bits (102), Expect = 0.002
Identities = 60/263 (22%), Positives = 112/263 (42%), Gaps = 39/263 (14%)
Query: 1839 TGADLLEEHLGEIRNLR---QRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLE 1895
T D +E + +I + QRL + + E LE+ + + + N ++
Sbjct: 481 TTVDSVEGNASKILKMEKENQRLSKKV-------EILENEIVQEKQSLQNCQNLSKDLMK 533
Query: 1896 SIPQLCNENRVLREDNRRLQAQLSHVSREHSQET-ESLRE-ALLSSRSHLQELEKE---- 1949
QL LRE++ R Q ++ EH +T SLR+ + +S+ + ++++EKE
Sbjct: 534 EKAQLEKTIETLRENSER-QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKIL 592
Query: 1950 -------------LEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQ 1996
+E +K + ++ LE +EK + E L++ + LQ K+ L+
Sbjct: 593 HESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLK 652
Query: 1997 QQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRG 2056
CE+ E+L+ E E KK L ++ L + S L E LR
Sbjct: 653 ITCEK----IEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELR- 707
Query: 2057 QLEQSIQGNNCLRLQLQQ-QLES 2078
++++ C +++ Q QLE+
Sbjct: 708 ---RNVESLKCASMKMAQLQLEN 727
Score = 41.6 bits (96), Expect = 0.009
Identities = 164/839 (19%), Positives = 300/839 (35%), Gaps = 171/839 (20%)
Query: 805 QIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKV-----ASVESQGQEISGNRRQQL 859
Q KE+ I+ ++Q +D + A+ QEV +E V V QE + +
Sbjct: 136 QKKEEFIE--RIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNM 193
Query: 860 LLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESS-------------ERDRTLQVE 906
L L+ L+DER +E + + L F H SS E + L VE
Sbjct: 194 ALHLKRLIDERDEHSETIIELSEERDGL-HFLPHASSSAQSPCGSPGMKRTESRQHLSVE 252
Query: 907 LEGAQVLRSRLEEVLGRSLERL-------------------NRLETLAAIGGAAAGDDTE 947
L A+ RL + L E+L + L+ A D
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL 312
Query: 948 DTSTEFT---DSIEEEAAHHSHQ----QLVKVALEKS------LATVETQNPSFSPPSPM 994
D E D +E E + + + + K +E+ L +T +
Sbjct: 313 DALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372
Query: 995 GGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCL 1054
D L++E L L+A+ H E+ ++++EL + ++ L
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE-----------------NMTL 415
Query: 1055 ENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHN 1114
E A+ K+ M E++ GWE+E+ E LSE+ ++ H
Sbjct: 416 EMAQ-KQSMDESLHLGWELEQISRTSE-----------LSEAPQKSL----------GHE 453
Query: 1115 IINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFP 1174
+ L +L+ E S LT T+E + T + EGN +
Sbjct: 454 VNELTSSRLLKLEMENQS---------LTKTVEELRTTV--------DSVEGNASKILKM 496
Query: 1175 RPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQE-- 1232
++ L + L+N+ Q+ +L ++QL + + ++ E
Sbjct: 497 EKENQRLSKKVEI----LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ 552
Query: 1233 -KLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREE 1291
K+L E Q + R ++ E+ VK K+ ++ + + + S+ E E+ +
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQ 612
Query: 1292 TTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENI 1351
E E + E+G R L + EN+L +++ + E I
Sbjct: 613 IKK-ELEHYK-------------EKGERAEELENELHHLEKENELLQKKITNLKITCEKI 658
Query: 1352 LVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSSPHS 1411
L ++ +L+ + + K + + K+ L SLE+ +S
Sbjct: 659 EALEQENSELERENRKLKKTLDSFKNLTFQL-------ESLEK--------------ENS 697
Query: 1412 VPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWP 1471
DE+ L+ ++++ESL + S AQL E + +E
Sbjct: 698 QLDEE--------------NLELRRNVESL-KCASMKMAQLQLENKELESEKEQLKKGLE 742
Query: 1472 GKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFR 1531
S + + E+SY I R ++ ++ E L+ +++ Q
Sbjct: 743 LLKASFKKTERLEVSYQGLDIENQR--LQKTLENSNKKIQQLESELQDLEMENQTLQKNL 800
Query: 1532 EQLAQGSQLTERL---TSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKL 1587
E+L S+ E+L L + + EKD+ LE RL ++ + K+ +E K+
Sbjct: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859
Score = 39.7 bits (91), Expect = 0.035
Identities = 37/163 (22%), Positives = 71/163 (43%), Gaps = 20/163 (12%)
Query: 1850 EIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLRE 1909
+I L RLEES N +LR++L+ + E++ Q +E R+++
Sbjct: 974 KIAALEARLEESTNYNQQLRQELKT---------------VKKNYEALKQRQDEERMVQS 1018
Query: 1910 DNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQ 1969
+S + +E++ LL + L E+E+ + E+Q L L++ +
Sbjct: 1019 S-----PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLET 1073
Query: 1970 EVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSE 2012
+ + + + L+LQ LQ + LQ Q + Q +L S+
Sbjct: 1074 QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116
Score = 38.9 bits (89), Expect = 0.060
Identities = 53/249 (21%), Positives = 110/249 (44%), Gaps = 28/249 (11%)
Query: 1832 YQLNS-KPTGADLLEEHLGEIRNLRQRLEESICINDRLRE-QLEHR-LTSTARGRGSTSN 1888
+QL S + + L EE+L LR+ +E C + ++ + QLE++ L S
Sbjct: 687 FQLESLEKENSQLDEENL----ELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLE 742
Query: 1889 FYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEK 1948
+ +L + L +N+RLQ L + +++ Q L++ + + Q L+K
Sbjct: 743 LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN----QTLQK 798
Query: 1949 ELEHQKVER---QQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEK--- 2002
LE K+ +QL ++ + +QE +++ L++ + RL+ + + EE
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858
Query: 2003 ----QQLFESLQSELQIY-------EALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEV 2051
++ ++L E+ IY + L +K+ +K ++D + L DL +
Sbjct: 859 IGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKT 918
Query: 2052 RALRGQLEQ 2060
+ + LE+
Sbjct: 919 QQMNNDLEK 927
Score = 34.3 bits (77), Expect = 1.5
Identities = 45/197 (22%), Positives = 87/197 (44%), Gaps = 38/197 (19%)
Query: 1897 IPQLCNENRVLREDNRRLQAQL----SHVSREHSQETESLREALLSSRSHLQELEKELEH 1952
+ +L +N+VL E L+ QL + + H E E+L+ L ++ H E+E++++
Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ---LKAKLHDMEMERDMDR 402
Query: 1953 QKVE---RQQLLEDLREKQ--QEVLH--FREERLSLQENDSRLQHKLV-----------L 1994
+K+E + + ++ +KQ E LH + E++S S K + L
Sbjct: 403 KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRL 462
Query: 1995 LQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRAL 2054
L+ + E Q L ++++ +++ GN+ K LK + + L +V L
Sbjct: 463 LKLEM-ENQSLTKTVEELRTTVDSVEGNASKILK-----------MEKENQRLSKKVEIL 510
Query: 2055 RGQLEQSIQG-NNCLRL 2070
++ Q Q NC L
Sbjct: 511 ENEIVQEKQSLQNCQNL 527
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 139 bits (351), Expect = 2e-32
Identities = 472/2329 (20%), Positives = 882/2329 (37%), Gaps = 442/2329 (18%)
Query: 10 QHLNDL-KKENFSLKLRIYFL---EERMQQKYEASREDIYKRNIELKVEV---ESLKREL 62
QH DL KKEN K ++ + + Q+ E++ E K E+ E+ + E+
Sbjct: 978 QHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEV 1037
Query: 63 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKN- 121
++ K++ + + V + + E L++ E++ E +H+ + LE K+ ++ L K
Sbjct: 1038 EEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQM 1097
Query: 122 -----EAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALA-----QR 171
+ L++AE N + +KL +T N + GD V + T ++
Sbjct: 1098 NQTLQDKTNQIDLLQAEISENQAIIQKL--ITSNTDASDGDSVALVKETVVISPPCTGSS 1155
Query: 172 DKRIEELNQSLAAQERLVEQLSREKQQLLHLLEE--PTSMEVQPMTEELLKQQK--LNSH 227
+ EL + + A E+ EQL ++ Q+ L + + E + E LKQQK N
Sbjct: 1156 EHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRL 1215
Query: 228 ETTITQQSVSDSHLAELQEKIQ---------------QTEATNKI--LQEKLNEMSYELK 270
+ +QS + ++ + ++Q Q E+ + L+E L + + +
Sbjct: 1216 QEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHH 1275
Query: 271 C---------------AQESSQKQDGT-IQNLKETLKSRERETEELYQVIEGQNDTMAKL 314
++++S Q GT + +K LK E E EL + + K
Sbjct: 1276 TQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKK 1335
Query: 315 REMLHQSQ-----LGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQL 369
E + Q Q G S T + +V LQ L SQL+I L+ + R+ + +L
Sbjct: 1336 SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHL-RELQPKL 1394
Query: 370 ADAKQCVQFVEAAAHESEQQKEASWKHNQ--ELRKALQQLQEELQNKSQQLRAWEAEKYN 427
+ ++ + S+++++ S+ Q E AL ++Q E+ + ++A +
Sbjct: 1395 DELQKLI---------SKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEM 1445
Query: 428 EIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEA-----------NEMLLEK 476
+ + ++ I+ L L +Q +E E + + + L+A N+ L E+
Sbjct: 1446 QAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEE 1505
Query: 477 L---RQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEAT 533
L R I +L + + +EK+ L +L L ERD + + L N++
Sbjct: 1506 LSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSL 1565
Query: 534 MQSMESL-LRAKGL--EVEQLSTTCQNLQWLK----EEMETKFSRWQKEQESIIQQLQTS 586
S ESL L +GL + E+L ++L+ K E + K QKE E ++Q +
Sbjct: 1566 SSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENV 1625
Query: 587 LHDRNK------EVEDLSATLLCKLGPGQSEIAE------ELCQRLQRKERMLQDLLSDR 634
++ + V L KL ++ E E Q ++ + ++ +
Sbjct: 1626 SNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSK 1685
Query: 635 NKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALR---QYLGGR-DSL 690
+++LE E E L V ++ E L+ + EL+ ++ + L + SL
Sbjct: 1686 QQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSL 1745
Query: 691 MSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSR-DDSTSLTAKEDVSIPRSTLG----DL 745
MS+ +++ + G + Q +++ + D+ T++T + SIP T +
Sbjct: 1746 MSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSM 1805
Query: 746 DTVAGLEKELSNAKEELELMAK------KERESQMELSALQSMMAVQEEELQVQAADMES 799
T + + +AK ++K + ++ L+ +A EEE Q ++
Sbjct: 1806 STRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQT 1865
Query: 800 L--TRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQ 857
L +N + + KD +++++ E++ M L Q++ +V ++ +E + +
Sbjct: 1866 LENEKNTLLSQISTKDGELKMLQ-EEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEE 1924
Query: 858 QLLLMLEGL----------VDERSRLNEALQAE-----------RQLYSSLVKFHAHPES 896
+L+ L L V + NE L++E + LVK ES
Sbjct: 1925 RLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVES 1984
Query: 897 SERDRTLQVELEGAQ--------------VLRSRLEEVLGRSLERLNRLETLAAIGGAAA 942
R L+ +++GAQ +L+ + +EV + + E ++A+
Sbjct: 1985 EIRKEYLE-KIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVK 2043
Query: 943 GDDTEDTST----EFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDS 998
+ T + E T +A H + ++A K L +TQ+ ++
Sbjct: 2044 ALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLD-DTQS-----------EA 2091
Query: 999 NRCLQEEMLHLRAEFHQHLE----EKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCL 1054
R L + L L+ E + E + ++ +E+L+ Q EE +++ + +L
Sbjct: 2092 ARVLADN-LKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRR 2150
Query: 1055 ENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGL---SESSLQAEFRKLQGKLKN 1111
E L+E +GE + +++ ++ + +++ VT+ S SSLQ + ++ + K
Sbjct: 2151 EKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKK 2210
Query: 1112 AHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVR 1171
K + SKE +L + L + +++ H EE + +
Sbjct: 2211 WER-----KFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSI----------HMEELKINI- 2254
Query: 1172 PFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQ 1231
L+ Q + Q Q + +L G + L SQL + + Y Q
Sbjct: 2255 -----SRLEHDKQIWESKAQTEVQLQQK-----VCDTLQGENKELLSQLEETRHLYHSSQ 2304
Query: 1232 EKLLLSEATVFA-------QANELEKYRVMLTG-ESLVKQDSKQIQVDLQDLGYETCGRS 1283
+L E+ + + +N LEK + E +++Q IQ YE +
Sbjct: 2305 NELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQ--NSKFSYEQL-ET 2361
Query: 1284 ENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLAS-----SSERKPLENQLGK 1338
+ +A RE T+ E ++KE ++ L ++ +A E K LEN L +
Sbjct: 2362 DLQASRELTS--RLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQ 2419
Query: 1339 QEEFRVYGKSENILVLRKDIKDLKAQLQNANKVI--QNLKSRVRSLSVTSDYSSSLERPW 1396
+EE + + EN K D QL K I +N++ + + S SS
Sbjct: 2420 EEEENIVLEEEN-----KKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSS------ 2468
Query: 1397 KLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNG 1456
+ D + ++ QLE +
Sbjct: 2469 -------------------------------------LQNDRDRIVGDYQQLEERHLSII 2491
Query: 1457 LEEKLAEELRSASWPGKYDSLIQDQARELSYLRQKIREGRG-ICYLITRHAK---DTVKS 1512
LE+ D LIQ+ A E + L+++IR R + L + +AK + ++
Sbjct: 2492 LEK---------------DQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQY 2536
Query: 1513 FEDLLRSNDI-DYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSR 1571
EDL + I D Q QL Q +L E +KL K +SE+ L L
Sbjct: 2537 REDLNQVITIKDSQQKQLLEVQLQQNKEL-ENKYAKLEEKLKESEEANEDLRRSFNALQE 2595
Query: 1572 ELQEKEKVIEVLQAKLD--ARSLT------------------PSSSHALSDSHRSPSSTS 1611
E Q+ K IE L+ + R +T H LS S
Sbjct: 2596 EKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRI 2655
Query: 1612 FLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSSTS--------- 1662
+E C + + E+K + H H A + + T+
Sbjct: 2656 AELEEELVCVQKEAAKKVGEIEDKL-----KKELKHLHHDAGIMRNETETAEERVAELAR 2710
Query: 1663 --------------ASQGAKAESNSNPISLPTPQNTPKEANQAHSGF---HFHSIPKLAS 1705
++G A+ S S+ + QN+ AN+ + S+ +LA
Sbjct: 2711 DLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQ 2770
Query: 1706 LPQAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGESASTVPPAST 1765
L + L + L S T + E + L + Q+L +QL
Sbjct: 2771 LKEQGLLNRERDAL-LSETAFSMNSTEENSLSHLEKLNQQLLSKDEQL------------ 2817
Query: 1766 ATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVSGDL 1825
LS+ LE SY N Q S +++ R W+ + + S G
Sbjct: 2818 -LHLSSQLE--DSY--NQVQSFSKAMASLQNER---------DHLWNELEKFRKSEEGKQ 2863
Query: 1826 SSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGS 1885
S + Q ++ P L++ + ++N R RL + + L++Q
Sbjct: 2864 RSAA---QPSTSPAEVQSLKKAMSSLQNDRDRLLKEL---KNLQQQ-------------- 2903
Query: 1886 TSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQET-------ESLREALLS 1938
Y Q + I +L L+AQL +E+ +T E LR+ LS
Sbjct: 2904 ----YLQINQEITEL-----------HPLKAQL----QEYQDKTKAFQIMQEELRQENLS 2944
Query: 1939 SRSHLQELEKELE----HQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVL 1994
+ L +L E H++ ++Q L + +K Q++ H + L+ + S+ Q V
Sbjct: 2945 WQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQ 3004
Query: 1995 LQQQCE-EKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRA 2053
Q+Q E + Q+ + E L LK L+S+ S L+ E
Sbjct: 3005 YQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNT 3064
Query: 2054 LRGQLEQSIQG------------NNCLRLQLQ-QQLESGAGKASLSPSS 2089
L QL + Q N+C L+ Q Q+L++G ++P +
Sbjct: 3065 LSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGA 3113
Score = 134 bits (336), Expect = 1e-30
Identities = 303/1539 (19%), Positives = 602/1539 (39%), Gaps = 243/1539 (15%)
Query: 5 YRTLSQHLNDLKKENFSLKLRIYFLEERMQQKY------EASREDIYKRNIELKVEVESL 58
Y L Q ++ E ++ + + + Q+ Y EA++++ K+ E + E+E +
Sbjct: 1615 YEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEM 1674
Query: 59 KRELQDKKQHLDKTWADVENLNSQNEAELR-----------------RQFEERQQETEHV 101
K +++ + + ++E N + AE+ +E + +
Sbjct: 1675 KEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKME 1734
Query: 102 YELLENKIQLLQEESRLAKNEAARMAALVEAE--KECNLELSEKLKGVTKNWED----VP 155
YE L K Q L E E + +E K+ NLE +EK T E+ +P
Sbjct: 1735 YETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIP 1794
Query: 156 GDQVKPDQYTEAL----AQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEV 211
G+ + D + + ++ + N +++ ++++ QQ+ L E +E
Sbjct: 1795 GETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEE 1854
Query: 212 QPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKC 271
+ + Q N T ++Q S D L LQE++ + N+ +QE+L+ ++ +
Sbjct: 1855 EKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKET 1914
Query: 272 AQESSQK--------------------QDGTIQNLKETLKSRERET---------EELYQ 302
A+E QD T +K L E + EE Q
Sbjct: 1915 AEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQ 1974
Query: 303 VIEGQNDTMAKLRE---------------MLHQSQLGQLHSSEGTSPAQQQVALLDLQSA 347
+++ + +++R+ H +L +L + Q Q + Q
Sbjct: 1975 LVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEK 2034
Query: 348 LFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKE-ASWK----------- 395
+ + ++ L+ V + ++ L K+ +A H + Q E AS+K
Sbjct: 2035 ISALERTVKALEFVQTESQKDLEITKE--NLAQAVEHRKKAQAELASFKVLLDDTQSEAA 2092
Query: 396 ----HNQELRKALQQLQEELQNKSQQ--------LRAWEAEKYNEIRTQEQNIQHLNHSL 443
N +L+K LQ +E ++++ +Q L E + E + ++ + L
Sbjct: 2093 RVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREK 2152
Query: 444 SHKEQLLQEF--------RELLQYRDNSDKTL------EANEMLLEKLRQRIHDKAVALE 489
H E+ + E +E+ Q ++N D T+ + L+ R R+ D+A E
Sbjct: 2153 VHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWE 2212
Query: 490 RAIDEKFSALEE----KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKG 545
R + + EE KE L+ +R+ +E L+ +S E Q ES +
Sbjct: 2213 RKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQT-- 2270
Query: 546 LEVEQLSTTCQNLQWLKEEMETKFSRWQ---KEQESIIQQLQTSLHDRNKEVEDLSATL- 601
EV+ C LQ +E+ ++ + ++ + +L++ L ++ DLS +L
Sbjct: 2271 -EVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLE 2329
Query: 602 LCKLGPGQSE-IAEELCQRLQRK----ERMLQDLLSDRNKQVLEHE---MEIQGLLQSVS 653
CK G E I + +Q E++ DL + R HE M+ Q ++ +S
Sbjct: 2330 KCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLS 2389
Query: 654 TREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ-----APISNQQAEVTPTGC 708
+E+ Q A +L Q + EL+ L + ++ + +NQ E T
Sbjct: 2390 GKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKT-- 2447
Query: 709 LGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELM--- 765
+ K+ Q Q+ S S S + I +GD + E+ LS E+ +L+
Sbjct: 2448 IKKENIQQKAQLDSFVKSMSSLQNDRDRI----VGDYQQLE--ERHLSIILEKDQLIQEA 2501
Query: 766 AKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIP 825
A + + + E+ L+S M ++L + A +++ IQ +EDL + + ++ D +
Sbjct: 2502 AAENNKLKEEIRGLRSHM----DDLNSENAKLDA--ELIQYREDLNQVITIK--DSQQKQ 2553
Query: 826 AMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYS 885
+E Q+ L K A +E + +E S + L L +E+ L++ +++ + S
Sbjct: 2554 LLEVQLQQNKELENKYAKLEEKLKE-SEEANEDLRRSFNALQEEKQDLSKEIESLKVSIS 2612
Query: 886 SLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRL-ETLAAIGGAAAGD 944
L + + +L+ + RL + S +R+ L E L + AA
Sbjct: 2613 QLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAA-- 2670
Query: 945 DTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQE 1004
E D +++E H H + + ET+ +E
Sbjct: 2671 ---KKVGEIEDKLKKELKHLHH--------DAGIMRNETET----------------AEE 2703
Query: 1005 EMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMG 1064
+ L + + ++ +E K L AQI+ G S+S ++N+ E ELK +
Sbjct: 2704 RVAELARDLVEMEQKLLMVTKENKGLTAQIQSFG-RSMSSLQNSRDHANEELDELKRKYD 2762
Query: 1065 EAMSDGWEIEE----DKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLK 1120
++ + +++E ++E+ ++ ET + E+SL + KL +L ++ +
Sbjct: 2763 ASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSL-SHLEKLNQQL------LSKDE 2815
Query: 1121 EQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLD 1180
+ L LSS+ +S + ++++ L K + EEG + +S
Sbjct: 2816 QLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEG--------KQRSAA 2867
Query: 1181 LGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEAT 1240
+T + L ++ SL L +L +Q+Y + +++
Sbjct: 2868 QPSTSPAEVQSL----------KKAMSSLQNDRDRLLKELKNLQQQYLQINQEI----TE 2913
Query: 1241 VFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEH 1300
+ +L++Y+ +++++ +Q + Q E R E +S E E
Sbjct: 2914 LHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQ---------HELHQLRMEKSSWEIHER 2964
Query: 1301 NSLKEMVLM------EGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVL 1354
+KE LM + L Q +SSS+ +PL+ Q +Q + L
Sbjct: 2965 R-MKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNL 3023
Query: 1355 RKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLE 1393
+ + L+ QL ++ K I + R++ L+ S++S LE
Sbjct: 3024 VYETELLRTQLNDSLKEIHQKELRIQQLN--SNFSQLLE 3060
Score = 123 bits (308), Expect = 2e-27
Identities = 327/1641 (19%), Positives = 661/1641 (40%), Gaps = 328/1641 (19%)
Query: 7 TLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKK 66
+L++++ ++K + ++ L Q + + S+ D K + E ++E+E +K +LQ+K+
Sbjct: 106 SLNKYIEEMKAQGGTV------LPTEPQSEEQLSKHD--KSSTEEEMEIEKIKHKLQEKE 157
Query: 67 QHLDKTWADVENLNSQNEAELRRQFEE------RQQETEHVYELLENKIQLLQEE---SR 117
+ + A + ++ A+ + EE + QE E L+ ++ Q E +
Sbjct: 158 ELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQ 217
Query: 118 LAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEE 177
+ + + AR V ++ L+L + T+ + + Q K +++ E+L R + ++
Sbjct: 218 VVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDL 277
Query: 178 LNQSLAAQERLVEQLSREKQQL------LHLLEEPTSMEVQPMTEEL---LKQQKLNSH- 227
L Q L A E+ + LS++ QQ+ L E E + + E++ + ++KL+ H
Sbjct: 278 LQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHN 337
Query: 228 --------------------ETTITQQSVSDSHLAELQEK---IQQTEATNKILQEKLNE 264
E ++ H AE++EK I + T + LQ +
Sbjct: 338 LQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDA 397
Query: 265 M----SYELKCAQESSQKQDGTIQNLKETLKSRERETEE-LYQVIEGQNDTMAKLREMLH 319
+ S L+ E + + TIQ L++ L+ + +E + L ++ Q++T ++
Sbjct: 398 LKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDV 457
Query: 320 QSQLGQLHSSEGTSPAQQQVALLDLQ-SALFCSQLEIQKL---------QRVVRQKERQL 369
++ Q + E + Q++V L+ + AL S +E+++L Q + + + +
Sbjct: 458 YNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRT 517
Query: 370 ADAKQCVQFV---------EAAAHESEQ---QKEASWKHNQ--ELRKALQQLQEELQNKS 415
+A + V + ++A ES Q + S KH + L +++ QEE+
Sbjct: 518 GEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLK 577
Query: 416 QQLRAWEAEKY-NEIRTQEQNIQHLNHSLS----------------------------HK 446
QL+ AE+ +E+ Q++ Q ++ K
Sbjct: 578 LQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEK 637
Query: 447 EQLLQEFR--------------ELLQYRDNSDKTLEA-------NEMLLEKLRQRIHDKA 485
EQ E + EL + + DK+L A ++ LE+L+ +I +
Sbjct: 638 EQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELE 697
Query: 486 VALERAIDEKFSALEEKEKELRQLRLAVRERDHD----------LERLRDVLSSNEATMQ 535
+ +A + L+EK KE+ L + E + L RD L S +
Sbjct: 698 LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKEL- 756
Query: 536 SMESLLRAKGLEVEQLSTTCQNLQWLKEEMET-----------KFSRWQKEQESIIQQLQ 584
SM + LRA+ ++E + + L E +T S K ++ I+ LQ
Sbjct: 757 SMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQ 816
Query: 585 TSLHD---RNKEVEDLSATLLCKLGPGQSEIAE--ELCQRLQRKERMLQDLLSDRNKQV- 638
L D + E L +L +L +SE+ E E + + K L LS + ++
Sbjct: 817 NELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEIT 876
Query: 639 ------LEHEMEIQGLLQSVSTREQE----SQAAAEKLVQALMERNS---ELQALRQYLG 685
LE + +++ L Q++ ++Q+ S + EK+VQ E+ S E++ L++ L
Sbjct: 877 KMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLN 936
Query: 686 ----GRDSLMSQAPISNQQA--------EVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKE 733
++ Q N+ + E++P G + K+ Q + +++ +
Sbjct: 937 LLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQ 996
Query: 734 DVSIPRSTLGDLDTVAGLEKELSNAKEEL------------ELMAKKERESQMELSA--- 778
I R L L V+ LE+EL+N K+E E+ KE + E
Sbjct: 997 AALINRKEL--LQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSK 1054
Query: 779 -------LQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVD----------- 820
L+ ++ +E ELQ D+E + + L+K + L D
Sbjct: 1055 CQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAE 1114
Query: 821 -PEDIPAMERLT---------QEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDER 870
E+ +++L V L++E V + S + + +L + L E+
Sbjct: 1115 ISENQAIIQKLITSNTDASDGDSVALVKETVV-ISPPCTGSSEHWKPELEEKILALEKEK 1173
Query: 871 SRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEV---------- 920
+L + LQ +++K ++ E++R L+ EL+ + +RL+E
Sbjct: 1174 EQLQKKLQEALTSRKAILK-----KAQEKERHLREELKQQKDDYNRLQEQFDEQSKENEN 1228
Query: 921 LGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLAT 980
+G L +L +++ +I G D ++ S T +EE + Q + LE +L
Sbjct: 1229 IGDQLRQL-QIQVRESIDGKLPSTDQQE-SCSSTPGLEEPLFKATEQHHTQPVLESNLCP 1286
Query: 981 VETQNPSFSPPSPMGGDSNRCLQEEMLHLRAE-------FHQHLEEKRKAEEELKELKAQ 1033
+ + S + GG S ++ ++ + AE E K EE+ +L+ Q
Sbjct: 1287 -DWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQ 1345
Query: 1034 IEEAG-----FSSVSH---IRNTMLSLCLENAELK----EQMGEAMSDGWEIEEDKEKGE 1081
I + G +VSH + L LE+++L+ E + E E+++ K E
Sbjct: 1346 INKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKE 1405
Query: 1082 VMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLVH 1141
V + + LSE +A K+Q ++ ++I L QL + +KE + ++ +L V
Sbjct: 1406 EDVSYLSGQ--LSEK--EAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERI-KQLQVE 1460
Query: 1142 LTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDP 1201
L ++ E +G + + Q + + R ++L +N+S
Sbjct: 1461 LCEMKQK--PEEIGEESRAKQQIQRKLQAALISRKEALK------------ENKSL---- 1502
Query: 1202 GPQSAFSLP-GSTQHLRSQLSQCKQRY--QDLQEKLLLSEATVFAQANE---LEKYRVML 1255
Q SL G+ + L L+ + + Q+ ++ +L + + + E R +L
Sbjct: 1503 --QEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLL 1560
Query: 1256 TGESL-------------VKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNS 1302
+SL + +D +++ +++ L S E+ + E E
Sbjct: 1561 ENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYE---- 1616
Query: 1303 LKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLK 1362
+L++ +++ +ER + +QE+ +YGK + + K+ +
Sbjct: 1617 ----ILLQSY--------ENVSNEAERIQHVVEAVRQEKQELYGKLRS---TEANKKETE 1661
Query: 1363 AQLQNANKVIQNLKSRVRSLS 1383
QLQ A + ++ +K ++R +
Sbjct: 1662 KQLQEAEQEMEEMKEKMRKFA 1682
Score = 99.0 bits (245), Expect = 5e-20
Identities = 360/1904 (18%), Positives = 729/1904 (38%), Gaps = 249/1904 (13%)
Query: 203 LEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKL 262
L + + ME T+E ++++ + + + + + +LQ+K + + K K+
Sbjct: 34 LHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKI 93
Query: 263 NEMSYELKCAQESSQK-------QDGTI----QNLKETLKSRERETEELYQVIEGQNDTM 311
++ K S K Q GT+ +E L ++ + E IE +
Sbjct: 94 KKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKL 153
Query: 312 AKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLAD 371
+ E++ Q QL ++ PAQ +++ + Q ++Q+ + + + QL+
Sbjct: 154 QEKEELISTLQ-AQLTQAQAEQPAQSST---EMEEFVMMKQ-QLQEKEEFISTLQAQLSQ 208
Query: 372 AKQCVQFVEAAAHESEQQKEASWK-----HNQELRKALQQ--LQEELQNKSQQLRAWEAE 424
+ E AA + ++K+A ++ H EL + + Q ++ E+Q K + L+ E
Sbjct: 209 TQ-----AEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEE 263
Query: 425 KYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTL--------EANEMLLEK 476
+ + Q + L L+ EQ Q + LQ + TL E +++LLEK
Sbjct: 264 HEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEK 323
Query: 477 LRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQS 536
+ + ++ ++ +E LE+ E+ +A ++S
Sbjct: 324 MELEVAERKLSFHNLQEEMHHLLEQFEQ----------------------AGQAQAELES 361
Query: 537 MESLLRAK-GLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVE 595
S L K E+E+ ++ +LQ +E+++ + + ++Q D+N++
Sbjct: 362 RYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQ-------DKNEQAV 414
Query: 596 DLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTR 655
+ T+ ++L +LQ+K + + L+ Q +HE Q V
Sbjct: 415 QSAQTI------------QQLEDQLQQKSKEISQFLNRLPLQ--QHETASQTSFPDV--Y 458
Query: 656 EQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTD- 714
+ +QA E+ + +L +R EL+ + L L+S + +AE L Q
Sbjct: 459 NEGTQAVTEENIASLQKRVVELENEKGAL-----LLSSIELEELKAE---NEKLSSQITL 510
Query: 715 -QGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQ 773
+ + D S + D++ RS+ + LE S +EL ++ + +E+Q
Sbjct: 511 LEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQ 570
Query: 774 MELSALQ-SMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLV---DPEDIPAMER 829
E++ L+ + + EE + D + + Q++ + I ++M++ +D P M
Sbjct: 571 EEIAFLKLQLQGKRAEEADHEVLDQKEMK---QMEGEGIAPIKMKVFLEDTGQDFPLMPN 627
Query: 830 LTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVK 889
+ + ++ AS E Q +R + + + + V+ +S + ++ L +
Sbjct: 628 EESSLPAVEKEQASTEHQ------SRTSEEISLNDAGVELKSTKQD---GDKSLSAVPDI 678
Query: 890 FHAHPESSERDRTLQVELE----GAQVLRSRLEEVLGRSLERLNRL---ETLAAIGGAAA 942
H + ER ++ +ELE AQ + + + + + LN+L A ++A
Sbjct: 679 GQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSA 738
Query: 943 GDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCL 1002
+ + ++E + + VK LE +LA E Q S D+ L
Sbjct: 739 FTALSEERDQLLSQVKELSMVTELRAQVK-QLEMNLAEAERQR-RLDYESQTAHDN--LL 794
Query: 1003 QEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGF---SSVSHIRNTMLSLCLENAEL 1059
E++ L E + + EL +++ Q E S S ++N S LE AE
Sbjct: 795 TEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKE-SEVLEGAER 853
Query: 1060 KEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLL 1119
+ + + + KE ++ ++ ++ +LQ + ++ K + I +
Sbjct: 854 VRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQ---QTIEEKDQQVTEISFSM 910
Query: 1120 KEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSL 1179
E++V ++E S L V + + E++N K + EE N
Sbjct: 911 TEKMVQLNEEKFS-----LGVEIKTLKEQLNLLSRAEEAKKEQVEEDN------------ 953
Query: 1180 DLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEA 1239
V + N + G S L L+ + Q K++ Q L++
Sbjct: 954 ------EVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQ----AALINRK 1003
Query: 1240 TVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEE 1299
+ + + LE+ L ES K+I + + G E EN+ E+ + +C+E
Sbjct: 1004 ELLQRVSRLEEELANLKDES-----KKEIPLSETERG-EVEEDKENKEYSEKCVTSKCQE 1057
Query: 1300 HNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRK--D 1357
+ + E + RK LE +L +E+F+ K N + K
Sbjct: 1058 IEIYLKQTISE----------KEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQ 1107
Query: 1358 IKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDE 1417
I L+A++ +IQ L + S + SD S + GSS H P+ +E
Sbjct: 1108 IDLLQAEISENQAIIQKL---ITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEE 1164
Query: 1418 GWLSDGTGAFYSPGLQAKKDLE-------SLIQRVSQLEAQLPK---------NGLEEKL 1461
L A Q +K L+ +++++ + E L + N L+E+
Sbjct: 1165 KIL-----ALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQF 1219
Query: 1462 AEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFED-----L 1516
E+ + G +Q Q RE + + + C + K+ E +
Sbjct: 1220 DEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPV 1279
Query: 1517 LRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEK 1576
L SN + S QG ++ ++L + E ++ LE + EL +K
Sbjct: 1280 LESNLCPDWPSHSEDASALQGGTSVAQIKAQLK----EIEAEKVELELKVSSTTSELTKK 1335
Query: 1577 EKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKK 1636
+ + LQ +++ + L S + SH + L +LE+ S + I H E +
Sbjct: 1336 SEEVFQLQEQINKQGLEIESLKTV--SHEAEVHAESLQQKLES-SQLQIAG-LEHLRELQ 1391
Query: 1637 ASPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQA-HSGF 1695
+ +S K S G +E + + T ++ +A H+
Sbjct: 1392 PKLDELQKL--------ISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQL 1443
Query: 1696 HFHSIP-----KLASLPQAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQ 1750
+ K + + P S + + ++S EA +E + LQ
Sbjct: 1444 EMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQ 1503
Query: 1751 KQLGESASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGK 1810
++L + T+ T D+E+ S + + T+ LGR+ L +
Sbjct: 1504 EELSLARGTI---ERLTKSLADVESQVS-------AQNKEKDTV-LGRLA----LLQEER 1548
Query: 1811 WDVMRPQKGSVSGDLSSGSSVYQLNSKPTG-ADLLEEHLGEIRNLR-QRLEESICINDRL 1868
++ S+ + S SS L G + E+ + EI +L+ ++ ES ++
Sbjct: 1549 DKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKH 1608
Query: 1869 RE-QLEHR-LTSTARGRGSTSNFYSQGLESIPQ----LCNENRVLREDNRRLQAQLSHVS 1922
+E Q E+ L + + + +E++ Q L + R + + + QL
Sbjct: 1609 KELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAE 1668
Query: 1923 REHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQ 1982
+E + E +R+ S + + ELE+E + + E + +E + +L S++
Sbjct: 1669 QEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLL---SSNASMK 1725
Query: 1983 ENDSRLQHKLVLLQQQCEEKQQLFESLQSELQ-IYEALYGNSKK 2025
E R++ + L ++ + +SL E+Q + + GN K
Sbjct: 1726 EELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSK 1769
Score = 95.5 bits (236), Expect = 5e-19
Identities = 391/1950 (20%), Positives = 732/1950 (37%), Gaps = 320/1950 (16%)
Query: 304 IEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVR 363
+ G +DT +R L +L Q E + Q+ D+Q L ++ + +L+ ++R
Sbjct: 16 LSGDDDTDQNMRAPL-DPELHQESDMEFNNTTQE-----DVQERLAYAEQLVVELKDIIR 69
Query: 364 QKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEA 423
QK+ QL + +Q AA ++ + H + +L + EE++ + + E
Sbjct: 70 QKDVQLQQKDEALQEERKAADNKIKKLKL---HAKAKLTSLNKYIEEMKAQGGTVLPTEP 126
Query: 424 E------KYNEIRTQEQ-NIQHLNHSLSHKEQLLQEFRELL---QYRDNSDKTLEANEML 473
+ K+++ T+E+ I+ + H L KE+L+ + L Q + + E E +
Sbjct: 127 QSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFV 186
Query: 474 LEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQ--LRLAVRERDHDLERLRDVLSSN- 530
+ K + + ++ ++ +A + A + ++ +R+ R + R H+ E L+ V ++
Sbjct: 187 MMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADV 246
Query: 531 EATMQSMESLLRAKGLEVEQ-LSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHD 589
E MQ +L+ K E E+ L Q + L++E+ R Q + + QQ++ +
Sbjct: 247 ETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQL-QQMEAEHNT 305
Query: 590 RNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLL 649
VE L + E+AE +E M L ++ +Q + + E++
Sbjct: 306 LRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHH--LLEQFEQAGQAQAELESRY 363
Query: 650 QSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCL 709
++ + + + +L + ELQ+ L ++S + Q L
Sbjct: 364 SALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQL 423
Query: 710 GKQTDQGSMQIPS--------RDDSTSLTAKEDVSIPRSTLGDLDTVAGLEK---ELSNA 758
Q Q S +I + ++ S T+ DV + + +A L+K EL N
Sbjct: 424 EDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENE 483
Query: 759 KEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQL 818
K L L + + E + E L S + + E + + AD E ++ +
Sbjct: 484 KGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVS--------------EISI 529
Query: 819 VDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQ-------LLLMLEGLVDERS 871
VD + ++ +S E GQ++ N Q LLL ++ +E +
Sbjct: 530 VD---------------IANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIA 574
Query: 872 RLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLE-EVLGRSLERL-N 929
L LQ +R A E ++ Q+E EG ++ ++ E G+ + N
Sbjct: 575 FLKLQLQGKRAE-------EADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPN 627
Query: 930 RLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFS 989
+L A+ + E STE EE + + +K +T + + S S
Sbjct: 628 EESSLPAV-------EKEQASTEHQSRTSEEISLNDAGVELK-------STKQDGDKSLS 673
Query: 990 PPSPMGG---DSNRCLQEEMLHLRAEFHQ-------HLEEKRKAEEELKEL------KAQ 1033
+G D L+ ++L L FH+ +L+EK K L +L A
Sbjct: 674 AVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNAD 733
Query: 1034 IEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGL 1093
+ F+++S R+ +LS +++E E+ + + L
Sbjct: 734 NNSSAFTALSEERDQLLS--------------------QVKELSMVTELRAQVKQLEMNL 773
Query: 1094 SESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTEL 1153
+E+ Q R+L + + AH+ NLL EQ+ S E SK IE + EL
Sbjct: 774 AEAERQ---RRLDYESQTAHD--NLLTEQIHSLSIEAKSK---------DVKIEVLQNEL 819
Query: 1154 VGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGST 1213
+ Q E+ + +SL QL N+ G + +
Sbjct: 820 --DDVQLQFSEQSTLI-------RSLQ---------SQLQNKESEVLEGAERVRHISSKV 861
Query: 1214 QHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQ 1273
+ L LSQ + + + LL + V +E+ +T E K +Q++ +
Sbjct: 862 EELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT-EISFSMTEKMVQLNEE 920
Query: 1274 --DLGYE--TCGRSENEAER-EETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSE 1328
LG E T N R EE + EE N + S L + +
Sbjct: 921 KFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVS----------------SGLKQNYD 964
Query: 1329 RKPLENQLGKQE---EFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVT 1385
Q+ K+E EF + K EN RK L+A L N +++Q + L+
Sbjct: 965 EMSPAGQISKEELQHEFDLL-KKENEQRKRK----LQAALINRKELLQRVSRLEEELANL 1019
Query: 1386 SDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLI--- 1442
D S E P G +E D YS K E I
Sbjct: 1020 KDESKK-EIPLSETERGEVE---------------EDKENKEYSEKCVTSKCQEIEIYLK 1063
Query: 1443 QRVSQLEAQLP--KNGLEEKLAEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICY 1500
Q +S+ E +L + LEEKLA E + + + + +QD+ ++ L+ +I E + I
Sbjct: 1064 QTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQ 1123
Query: 1501 -LITRHA-----------KDTVKSFEDLLRSND-----IDYYLGQSFREQLAQGSQLTER 1543
LIT + K+TV S++ ++ + +E+ +L E
Sbjct: 1124 KLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEA 1183
Query: 1544 LTSKLSTKDHKSEKDQAGLEPLAL------RLSRELQEKEKVIEVLQAKLDARSLTPSSS 1597
LTS+ + EK++ E L RL + E+ K E + +L + S
Sbjct: 1184 LTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRES 1243
Query: 1598 H----ALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAV 1653
+D S SST L + L ++ PSHS+ SA+
Sbjct: 1244 IDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDA-----SAL 1298
Query: 1654 LSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKLASLPQAPLPS 1713
+ +Q + E+ + L T + ++ F L L +
Sbjct: 1299 QGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKT 1358
Query: 1714 APSSFLPFSPTGPLLLGCCETPVVSLA---EAQQELQMLQK--------------QLGES 1756
+ + L + + L E Q +L LQK QL E
Sbjct: 1359 VSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEK 1418
Query: 1757 ASTVPPASTATLLSNDL-EADSSYYLNSAQPHSP--PRGTIELGRILE-PGYLG--SSGK 1810
+ + T + DL +A + A+ H + +EL + + P +G S K
Sbjct: 1419 EAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAK 1478
Query: 1811 WDVMRPQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLRE 1870
+ R + ++ +S ++ + S L+E L R +RL +S+ + +
Sbjct: 1479 QQIQRKLQAAL---ISRKEALKENKS-------LQEELSLARGTIERLTKSLA-DVESQV 1527
Query: 1871 QLEHRLTSTARGR-GSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQ-- 1927
+++ T GR + + + + EN+ L L+ L ++ + +
Sbjct: 1528 SAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLV 1587
Query: 1928 -ETESLREALLSSRSHLQELEKELEHQ-------------KVER-QQLLEDLREKQQEVL 1972
E ESL+ + ++ + QE KEL+ + + ER Q ++E +R+++QE+
Sbjct: 1588 KEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELY 1647
Query: 1973 --------HFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSE-----LQIYEAL 2019
+ +E LQE + ++ +++ + KQQ L+ E +++ A
Sbjct: 1648 GKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPA- 1706
Query: 2020 YGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQ---QQL 2076
G++ K L + + +L + E L + + + + L ++Q Q+
Sbjct: 1707 -GDTAKECMETLLSS--NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763
Query: 2077 ESGAGK-ASLSPSSINQNFPASTDPGNKQL 2105
E K A+L + + N T+ G + +
Sbjct: 1764 EGNVSKQANLEATEKHDNQTNVTEEGTQSI 1793
Score = 85.1 bits (209), Expect = 7e-16
Identities = 147/694 (21%), Positives = 284/694 (40%), Gaps = 96/694 (13%)
Query: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
R L H++DL EN L + E + Q ++ K+ +E++++ +EL++K
Sbjct: 2513 RGLRSHMDDLNSENAKLDAELIQYREDLNQVITI-KDSQQKQLLEVQLQQN---KELENK 2568
Query: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLEN----------KIQLLQEE 115
L++ + E N +LRR F Q+E + + + +E+ ++ LQEE
Sbjct: 2569 YAKLEEKLKESEEANE----DLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEE 2624
Query: 116 SRLA---------KNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTE 166
L + E R++AL + ++ EL E+L V K G+ +
Sbjct: 2625 GTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKEL 2684
Query: 167 ALAQRDKRIEELNQSLAAQERLVE---QLSREKQQLLHLLEEPTSM--EVQPMTEELLKQ 221
D I N++ A+ER+ E L +Q+LL + +E + ++Q +
Sbjct: 2685 KHLHHDAGIMR-NETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSL 2743
Query: 222 QKLNSH--ETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESS--- 276
Q H E + D+ L EL + +++ N+ L+E ++ + +E+S
Sbjct: 2744 QNSRDHANEELDELKRKYDASLKELAQ-LKEQGLLNRERDALLSETAFSMNSTEENSLSH 2802
Query: 277 -QKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLR----------EMLHQSQLGQ 325
+K + + + E L + E+ Y ++ + MA L+ E +S+ G+
Sbjct: 2803 LEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGK 2862
Query: 326 LHSSE--GTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFV---E 380
S+ TSPA+ Q L+ A+ Q + +L + ++ ++Q Q + + +
Sbjct: 2863 QRSAAQPSTSPAEVQ----SLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLK 2918
Query: 381 AAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLN 440
A E + + +A +ELR+ Q EL + +WE +E R +EQ + ++
Sbjct: 2919 AQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEI---HERRMKEQYLMAIS 2975
Query: 441 ---HSLSHKEQLLQEFRE--------LLQYR-----------DNSDKTLEANEMLLEKLR 478
LSH + L++E R +QY+ D S + E+L +L
Sbjct: 2976 DKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLN 3035
Query: 479 ---QRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQ 535
+ IH K + +++ LEEK QL + + + D+L ++ A ++
Sbjct: 3036 DSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLL-NHCAVLE 3094
Query: 536 SMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVE 595
L+A L ++ Q + + + + R E + + Q L + +EV
Sbjct: 3095 KQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELR---EPQQSFSEAQQQLCNTRQEVN 3151
Query: 596 DLSATLLCK-----LGPGQSEIAEELCQRLQRKE 624
+L L + +AEE +RL+ E
Sbjct: 3152 ELRKLLEEERDQRVAAENALSVAEEQIRRLEHSE 3185
Score = 43.5 bits (101), Expect = 0.002
Identities = 116/554 (20%), Positives = 219/554 (39%), Gaps = 100/554 (18%)
Query: 1850 EIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLRE 1909
EI+ L+++L + +EQ+E ++ + + G S +L +E +L++
Sbjct: 927 EIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKK 986
Query: 1910 DN----RRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLED-- 1963
+N R+LQA L + +E Q L E L + + E +KE+ + ER ++ ED
Sbjct: 987 ENEQRKRKLQAALIN-RKELLQRVSRLEEELANLKD---ESKKEIPLSETERGEVEEDKE 1042
Query: 1964 -----------------------LREKQQEVLHFR---EERLSLQENDSRLQHKLVLLQQ 1997
+ EK+ E+ H R EE+L+ +E + Q + + Q
Sbjct: 1043 NKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEE---QFQALVKQMNQ 1099
Query: 1998 QCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRAL--- 2054
++K + LQ+E+ +A+ + L + DA D LV E +
Sbjct: 1100 TLQDKTNQIDLLQAEISENQAII----QKLITSNTDAS-----DGDSVALVKETVVISPP 1150
Query: 2055 --------RGQLEQSIQGNNCLRLQLQQQLESGAG-------KASLSPSSINQNFPASTD 2099
+ +LE+ I + QLQ++L+ KA + + D
Sbjct: 1151 CTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKD 1210
Query: 2100 PGNK------QLLLQDSAVSPPVRDVGMNS--------PALVFPSSASSTPGSETPIINR 2145
N+ + ++ + +R + + P+ S SSTPG E P+
Sbjct: 1211 DYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKA 1270
Query: 2146 ANGLGLDTSPVMKTP--PKLEGDATDGSFANKHGRHVIGHIDDYSALRQQIAEGKLLVKK 2203
T PV+++ P + D S A + G V A ++I K+ ++
Sbjct: 1271 TEQH--HTQPVLESNLCPDWPSHSEDAS-ALQGGTSVA----QIKAQLKEIEAEKVELEL 1323
Query: 2204 IVSLVRSACSFPGLEA-QGTEVLGSKGIHELRSSTSALHHALEESASLLTMFWRAALPST 2262
VS S + E Q E + +G+ E+ S + H A + SL + L S+
Sbjct: 1324 KVSSTTSELTKKSEEVFQLQEQINKQGL-EIESLKTVSHEAEVHAESL-----QQKLESS 1377
Query: 2263 HIPVLPGKVGESTERELLELRTKVSKQERLLQSTTEHLKNANQQKESMEQFIVSQLTRTH 2322
+ + + + +L EL+ +SK+E +L +KE+ I +++
Sbjct: 1378 QLQIAGLEHLRELQPKLDELQKLISKKEE----DVSYLSGQLSEKEAALTKIQTEIIEQE 1433
Query: 2323 DVLKKARTNLEVKS 2336
D++K T LE+++
Sbjct: 1434 DLIKALHTQLEMQA 1447
Score = 36.6 bits (83), Expect = 0.30
Identities = 83/390 (21%), Positives = 146/390 (37%), Gaps = 63/390 (16%)
Query: 1914 LQAQLSHVS--REHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLED-LREKQQE 1970
++ + SH+ ++ QE +S +AL S L + + E Q + Q LED L++K +E
Sbjct: 374 MEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKE 433
Query: 1971 VLHFREERLSLQ-----------------------ENDSRLQHKLVLLQQ---------- 1997
+ F RL LQ EN + LQ ++V L+
Sbjct: 434 ISQFLN-RLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSI 492
Query: 1998 QCEEKQQLFESLQSELQIYEALYGNSK-------------KGLKAYSLDACHQIPLSSDL 2044
+ EE + E L S++ + EA + ++ S + Q L +
Sbjct: 493 ELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTF 552
Query: 2045 SHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQ 2104
S E+ L +++++ + L+LQLQ + A L + Q P +
Sbjct: 553 SQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMK 612
Query: 2105 LLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDTSPVMKTPPKLE 2164
+ L+D+ P+ +S V AS+ S T + + L+ + V K +
Sbjct: 613 VFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRT-----SEEISLNDAGVELKSTKQD 667
Query: 2165 GDATDGSFANKHGRHVIG--HIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGT 2222
GD + + + IG H D+ L+ QI E +L K + E
Sbjct: 668 GDKSLSAVPD------IGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNL 721
Query: 2223 EVLGSKGIHELRSSTSALHHALEESASLLT 2252
L + +++SA EE LL+
Sbjct: 722 NQLIEEFKKNADNNSSAFTALSEERDQLLS 751
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 139 bits (349), Expect = 4e-32
Identities = 250/1150 (21%), Positives = 486/1150 (42%), Gaps = 158/1150 (13%)
Query: 32 RMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHL-DKTWADVENLNSQNEA----- 85
R +++ +A E++ K E + +VE E++ K Q L ++ E L ++ E
Sbjct: 849 RQEEELQAKDEELLKVK-EKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAE 907
Query: 86 ELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLK 145
E+R + ++QE E + LE++++ +E +++ +NE +M A ++ +E +L E+
Sbjct: 908 EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE---QLDEEEG 964
Query: 146 GVTK-NWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVE---QLSREKQQLLH 201
K E V + E L D+ + + + ++R+ E QL+ E+++ +
Sbjct: 965 ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Query: 202 LLEEPTSMEVQ-PMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQE 260
L + EV EE LK+++ E ++ + D +LQ++I + LQ
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL-DGETTDLQDQIAE-------LQA 1076
Query: 261 KLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQ 320
+++E+ +L+ A++ + Q + ETL +N+ + +RE+ Q
Sbjct: 1077 QIDEL--KLQLAKKEEELQGALARGDDETLH---------------KNNALKVVREL--Q 1117
Query: 321 SQLGQLH---SSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ 377
+Q+ +L SE S + + DL L + E++ ++ +Q V
Sbjct: 1118 AQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA 1177
Query: 378 FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQ 437
++ A E + EA Q++R+ EEL + +Q + ++A + +Q ++
Sbjct: 1178 ELKKALEEETKNHEA---QIQDMRQRHATALEELSEQLEQAKRFKA----NLEKNKQGLE 1230
Query: 438 HLNHSLSHKEQLLQEFRELLQYR----DNSDKTLEANEMLLEKLRQRIHDKAVALERAID 493
N L+ + ++LQ+ + +++ D + L A ++LR + +KA L+ +D
Sbjct: 1231 TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD 1290
Query: 494 EKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLST 553
+ LEE EK+ + + L+ +++L E T Q + R + LE E+
Sbjct: 1291 NVSTLLEEAEKKGIKFAKDAASLESQLQDTQELL--QEETRQKLNLSSRIRQLEEEK--- 1345
Query: 554 TCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATL--LCKLGPGQSE 611
+LQ +EE E +K E + LQ+ L D K+V+D T+ L + +
Sbjct: 1346 --NSLQEQQEEEEEA----RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399
Query: 612 IAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQES---QAAAEKLVQ 668
AE L QRL+ K L +N+ + E+ L + + Q + + +K Q
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRL----QQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 669 ALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTS 728
L E S +Y RD ++A K+T S+ +R +
Sbjct: 1456 LLAEEKS---ISARYAEERDRAEAEA--------------REKETKALSL---ARALEEA 1495
Query: 729 LTAKEDVSIPRSTL-GDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQE 787
L AKE+ L D++ + + ++ ELE K +R + ++ +++ + E
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE---KSKRALEQQVEEMRTQLEELE 1552
Query: 788 EELQVQAADMESLTRNIQ-IKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVES 846
+ELQ L N+Q +K +DLQ + E+ ++ LL ++V +E+
Sbjct: 1553 DELQATEDAKLRLEVNMQAMKAQFERDLQTR---------DEQNEEKKRLLIKQVRELEA 1603
Query: 847 QGQEISGNRRQQLLLMLE------GLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD 900
E+ R+Q+ L + L D +++ A +A ++ L K A + +R
Sbjct: 1604 ---ELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR- 1659
Query: 901 RTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAA---------IGGAAAGDDTEDTST 951
ELE A+ R +E+ +S E +L++L A A E
Sbjct: 1660 -----ELEEARASR---DEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERD 1711
Query: 952 EFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNR-------CLQE 1004
E D I A+ S K LE +A +E + + D R L
Sbjct: 1712 ELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNA 1771
Query: 1005 EMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMG 1064
E+ R+ + +++ E + KELKA+++E + S + T+ +L + +L+EQ+
Sbjct: 1772 ELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLE 1831
Query: 1065 EAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRK-----LQGKLKNAHNIINLL 1119
+E KE+ T++ L E +Q E + + +++ A+ + L
Sbjct: 1832 ---------QEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQL 1882
Query: 1120 KEQLVLSSKE 1129
K QL + +E
Sbjct: 1883 KRQLEEAEEE 1892
Score = 128 bits (322), Expect = 6e-29
Identities = 207/963 (21%), Positives = 409/963 (42%), Gaps = 134/963 (13%)
Query: 8 LSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQ 67
L + +L+ + LKL++ EE +Q ++ +N LKV V L+ ++ + ++
Sbjct: 1067 LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKV-VRELQAQIAELQE 1125
Query: 68 HLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMA 127
+ A S+N+AE +Q + +E E + LE+ + + L +A
Sbjct: 1126 DFESEKA------SRNKAE--KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA 1177
Query: 128 ALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQER 187
EL + L+ TKN E Q++ + A A +EEL++ L +R
Sbjct: 1178 -----------ELKKALEEETKNHE----AQIQDMRQRHATA-----LEELSEQLEQAKR 1217
Query: 188 LVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEK 247
L + KQ L T + ++L+Q K S ++ D+ + EL K
Sbjct: 1218 FKANLEKNKQGL------ETDNKELACEVKVLQQVKAESEH----KRKKLDAQVQELHAK 1267
Query: 248 IQQTEATNKILQEKLNEMSYEL---KCAQESSQKQDGTIQNLKETLKSRERETEELYQVI 304
+ + + L EK +++ EL E ++K+ +L+S+ ++T+EL
Sbjct: 1268 VSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELL--- 1324
Query: 305 EGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQK-LQRVVR 363
Q +T KL S++ QL + + QQ+ + E +K L++ V
Sbjct: 1325 --QEETRQKLN---LSSRIRQLEEEKNSLQEQQE------------EEEEARKNLEKQVL 1367
Query: 364 QKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEA 423
+ QLAD K+ V E+ K+ K +AL Q EE +L +
Sbjct: 1368 ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKD----AEALSQRLEEKALAYDKLEKTKN 1423
Query: 424 EKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELL-QYRDNSDKTLEANEMLLEKLRQRIH 482
E+ ++ H S+ E+ ++F +LL + + S + E + + R++
Sbjct: 1424 RLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREK-E 1482
Query: 483 DKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLR 542
KA++L RA++E A EE E++ +QLR + DL +D + N + +E R
Sbjct: 1483 TKALSLARALEEALEAKEEFERQNKQLRADM----EDLMSSKDDVGKN---VHELEKSKR 1535
Query: 543 AKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLL 602
A +VE++ T + L+ + E R + +++ Q + L R+++ E+ L+
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 603 CKLGPGQSEIAEELCQR---LQRKERMLQDL------LSDRNK---QVLEHEMEIQGLLQ 650
++ ++E+ +E QR + K++M DL + NK +V++ ++Q ++
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655
Query: 651 SVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLG 710
+E++A+ +++ E +L++L + ++ + + + AE
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD 1715
Query: 711 KQTDQGSMQIPSRDDSTSLTAK-----EDVSIPRSTLGDLD--------TVAGLEKELS- 756
+ T+ S + D+ L A+ E++ +S + L+ V L EL+
Sbjct: 1716 EITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAA 1775
Query: 757 ---------NAKEELELMAKKERESQMEL------------SALQSMMAVQEEELQVQAA 795
NA+++LE K+ + EL SAL++ + EE+L+ +A
Sbjct: 1776 ERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAK 1835
Query: 796 DMESLTRNIQIKEDLIKDLQMQLVD-----PEDIPAMERLTQEVLLLREKVASVESQGQE 850
+ + + ++ E +K++ MQ+ D + ME+ + L+ ++ E +
Sbjct: 1836 ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATR 1895
Query: 851 ISGNRRQQLLLMLEGLVDERSRLNEALQAE-RQLYSSLVKFHAHPESSERDRTLQVELEG 909
+ +RR+ L+ +D+ + NE L E L + L + SS R Q+ LEG
Sbjct: 1896 ANASRRK-----LQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEG 1950
Query: 910 AQV 912
A +
Sbjct: 1951 ASL 1953
Score = 123 bits (308), Expect = 2e-27
Identities = 236/1126 (20%), Positives = 464/1126 (41%), Gaps = 158/1126 (14%)
Query: 31 ERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQN---EAEL 87
E + E+ E+ +RN L+ E + ++ +QD ++ LD+ + L + EA++
Sbjct: 921 EEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKI 980
Query: 88 RRQFEE----RQQETEHVYE--LLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELS 141
++ EE Q ++ + E L+E++I + + +A +A + ++ +L
Sbjct: 981 KKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLE 1040
Query: 142 EKLKGVTKNWEDVPGDQVKPDQYT----EALAQRDKRIEELNQSLA-AQERLVEQLSREK 196
E+LK K +++ + K D T + +A+ +I+EL LA +E L L+R
Sbjct: 1041 ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGD 1100
Query: 197 QQLLH---LLEEPTSMEVQ-PMTEELLKQQKLNSHETTITQQSVSDSHLA---ELQEKIQ 249
+ LH L+ ++ Q +E + +K + ++ ++ +S+ A EL++ +
Sbjct: 1101 DETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLD 1160
Query: 250 QTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLK--------------ETLKSRER 295
T A ++ ++ E++ K +E ++ + IQ+++ E K +
Sbjct: 1161 TTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKA 1220
Query: 296 ETEELYQVIEGQNDTMAKLREMLHQ-------------SQLGQLHS--SEGTSPAQQQVA 340
E+ Q +E N +A ++L Q +Q+ +LH+ SEG + +V
Sbjct: 1221 NLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGD---RLRVE 1277
Query: 341 LLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQEL 400
L + S L Q E+ + ++ + E K+ ++F + AA Q Q+
Sbjct: 1278 LAEKASKL---QNELDNVSTLLEEAE------KKGIKFAKDAASLESQL--------QDT 1320
Query: 401 RKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYR 460
++ LQ+ + N S ++R E EK N ++ Q++ + +L ++Q+L +L +
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEK-NSLQEQQEEEEEARKNL--EKQVLALQSQLADTK 1377
Query: 461 DNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL 520
D L E LE+ ++++ A AL + ++EK A ++ EK +L+ + + DL
Sbjct: 1378 KKVDDDLGTIES-LEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDL 1436
Query: 521 ERLRDVLSSNEATMQSMESLL---------------RAKGLEVEQLSTTCQNLQWLKEEM 565
+ R V S+ E + + LL RA+ E+ + + L+E +
Sbjct: 1437 DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEAL 1496
Query: 566 ETK--FSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRK 623
E K F R K+ + ++ L +S D K V +L K + EE+ +L+
Sbjct: 1497 EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE-----KSKRALEQQVEEMRTQLEEL 1551
Query: 624 ERMLQ-----DLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQ 678
E LQ L + N Q ++ + E + + TR+++++ L++ + E +EL+
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFE-----RDLQTRDEQNEEKKRLLIKQVRELEAELE 1606
Query: 679 ALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIP 738
R+ + A S ++ E+ L Q +RD+ K
Sbjct: 1607 DERKQ-------RALAVASKKKMEID----LKDLEAQIEAANKARDEVIKQLRKLQAQ-- 1653
Query: 739 RSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADME 798
+ ++EL A+ + + + +ES+ +L +L++ + +EEL A E
Sbjct: 1654 ---------MKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEEL----ASSE 1700
Query: 799 SLTRNIQIKEDLIKDLQMQLVDPED--IPAMERLTQEVLLLREKVASVESQGQEISGNRR 856
R+ + + D + D + + RL + L E++ E E+ +R
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEE-EQSNMELLNDRF 1759
Query: 857 QQLLLMLEGLVDERSRLNEALQAERQL--YSSLVKFHAHPESSERDRTLQVELEGA---- 910
++ L ++ LN L AER S + ++ E LQ ELEGA
Sbjct: 1760 RKTTLQVD-------TLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ-ELEGAVKSK 1811
Query: 911 -QVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQL 969
+ S LE +G+ E+L + A AAA T + + + H
Sbjct: 1812 FKATISALEAKIGQLEEQLEQ----EAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQ 1867
Query: 970 VKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKE 1029
K +EK+ A ++ +N ++ L+ E E E+
Sbjct: 1868 YKEQMEKANARMKQLKRQLEEAEEEATRANASRRK----LQRELDDATEANEGLSREVST 1923
Query: 1030 LKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEE 1075
LK ++ G S S R+ L LE A L+ + S ++ E
Sbjct: 1924 LKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDVNE 1969
Score = 106 bits (265), Expect = 2e-22
Identities = 239/1192 (20%), Positives = 457/1192 (38%), Gaps = 188/1192 (15%)
Query: 354 EIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQ--------------- 398
+++ L +V RQ+E A ++ ++ E + +E KH Q
Sbjct: 840 KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 399 -ELRKALQQLQEELQNKSQQL---------RAWEAEKYNEIRTQEQ-----NIQHLNHSL 443
EL ++++ L K Q+L R E E+ N+I E+ +IQ L L
Sbjct: 900 TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 959
Query: 444 SHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKE 503
+E Q+ + + K +E +LLE + + +E I E S L E+E
Sbjct: 960 DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEE 1019
Query: 504 KELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKE 563
++ + L +++ + L + L E T Q +E R E L LQ +
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQID 1079
Query: 564 EMETKFSRWQKE-QESIIQQLQTSLHDRN--KEVEDLSATLLCKLGPGQSEIAEELCQRL 620
E++ + ++ ++E Q ++ + +LH N K V +L A + +SE A +
Sbjct: 1080 ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR--NKA 1137
Query: 621 QRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVST-REQESQAAAEKLVQALMERNSELQA 679
++++R L + L + K LE ++ Q + T REQE + L + +++Q
Sbjct: 1138 EKQKRDLSEEL-EALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQD 1196
Query: 680 LRQ-YLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSM----------QIPSRDDSTS 728
+RQ + + L Q + + G +TD + + S
Sbjct: 1197 MRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKK 1256
Query: 729 LTAKEDVSIPRSTLGD------LDTVAGLEKELSNAKEELELMAKKERESQMELSALQSM 782
L A+ + + GD + + L+ EL N LE KK + + ++L+S
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316
Query: 783 MAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVA 842
+ +E LQ + +L+ I+ E+ LQ Q + E+ A + L ++VL L+ ++A
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE--ARKNLEKQVLALQSQLA 1374
Query: 843 SVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRT 902
+ + + G + L + L+ + L++ L+ + Y L K + D
Sbjct: 1375 DTKKKVDDDLGT-IESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDD-- 1431
Query: 903 LQVELEGAQVLRSRLEE--------------VLGRSLERLNRLETLA------AIGGAAA 942
L V+L+ + + S LE+ + R E +R E A A+ A A
Sbjct: 1432 LTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARA 1491
Query: 943 GDDTEDTSTEFTD-------------SIEEEAAHHSHQ-QLVKVALEKSLATVETQNPSF 988
++ + EF S +++ + H+ + K ALE+ + + TQ
Sbjct: 1492 LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551
Query: 989 SPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNT 1048
D+ L+ M ++A+F + L+ + + EE K L + +R
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRL----------LIKQVRE- 1600
Query: 1049 MLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSE-SSLQAEFRKLQG 1107
L LE+ + + A EI+ + ++ E + + LQA+ + Q
Sbjct: 1601 -LEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR 1659
Query: 1108 KLKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGN 1167
+L+ A ++++ SKE KL L + I ++ EL S +H E+
Sbjct: 1660 ELEEA----RASRDEIFAQSKESEKKLK-----SLEAEILQLQEELASSERARRHAEQER 1710
Query: 1168 VTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRY 1227
+ A ++ N + + +L + L ++++Q ++
Sbjct: 1711 DEL------------------ADEITNSASGKS-------ALLDEKRRLEARIAQLEEEL 1745
Query: 1228 QDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDS-----------KQIQVDLQDLG 1276
++ Q + L +++ L E Q S K+++ LQ+L
Sbjct: 1746 EEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQEL- 1804
Query: 1277 YETCGRSENEA----------EREETTSPECEE-----------HNSLKEMVLMEGLCSE 1315
E +S+ +A + EE E +E LKE+ + +
Sbjct: 1805 -EGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQ---VED 1860
Query: 1316 QGRRGSTLASSSER-----KPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANK 1370
+ R E+ K L+ QL + EE + L++++ D + ++
Sbjct: 1861 ERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR-RKLQRELDDATEANEGLSR 1919
Query: 1371 VIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSD 1422
+ LK+R+R S +SSS +L LEG+S D+ E SD
Sbjct: 1920 EVSTLKNRLRRGGPIS-FSSSRSGRRQLH----LEGASLELSDDDTESKTSD 1966
Score = 95.9 bits (237), Expect = 4e-19
Identities = 265/1297 (20%), Positives = 499/1297 (38%), Gaps = 259/1297 (19%)
Query: 446 KEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALER--AIDEKFSALEEKE 503
+E+L + ELL+ ++ K E + K +Q + +K + E+ A E F+ EE
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 504 KELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKE 563
L + + E HDLE + +Q+ + ++A ++Q L+E
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQA-------------HIQDLEE 957
Query: 564 EMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRK 623
+++ E+E Q+LQ +++ + +L + E+ + ++
Sbjct: 958 QLD--------EEEGARQKLQLEKVTAEAKIKKMEEEIL---------LLEDQNSKFIKE 1000
Query: 624 ERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQY 683
+++++D +++ + Q+ E E + + L + + +E E+L + R +A R+
Sbjct: 1001 KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL 1060
Query: 684 LGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLG 743
G L Q I+ QA++ + ++ +R D +L + + R
Sbjct: 1061 DGETTDLQDQ--IAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQA 1118
Query: 744 DLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRN 803
+A L+++ + K K++R+ EL AL++ + E+ L AA E T+
Sbjct: 1119 Q---IAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL---EDTLDTTAAQQELRTKR 1172
Query: 804 IQIKEDLIKDL---------QMQLVDPEDIPAMERLTQEVLLLREKVASVES--QGQEIS 852
Q +L K L Q+Q + A+E L++++ + A++E QG E
Sbjct: 1173 EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETD 1232
Query: 853 GNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVEL-EGAQ 911
+ +L+ + E + L A+ Q H + SE DR L+VEL E A
Sbjct: 1233 NKELACEVKVLQQVKAESEHKRKKLDAQVQ--------ELHAKVSEGDR-LRVELAEKAS 1283
Query: 912 VLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVK 971
L++ L+ V ++ EEA
Sbjct: 1284 KLQNELDNV----------------------------------STLLEEAEKKG------ 1303
Query: 972 VALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEM---LHLRAEFHQHLEEKRKAEEELK 1028
+ K A++E+Q D+ LQEE L+L + Q EEK +E+ +
Sbjct: 1304 IKFAKDAASLESQLQ----------DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE 1353
Query: 1029 ELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETV- 1087
E EEA ++ +L+L + A+ K+++ + + +EE K+K E +
Sbjct: 1354 EE----EEAR----KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 1088 --VTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTST 1145
+ ++ L+ L+ +LQ +L + ++L ++ V S+ E K +LL S
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDL--TVDLDHQRQVASNLEKKQKKFDQLLAEEKSI 1463
Query: 1146 IERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQL-----DNQSQPRD 1200
R E + + + +E +++ ++L+ F QL D S D
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLAR-ALEEALEAKEEFERQNKQLRADMEDLMSSKDD 1522
Query: 1201 PGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESL 1260
G ++ L S + L Q+ + + + ++L+++L QA E K R+ + +++
Sbjct: 1523 VG-KNVHELEKSKRALEQQVEEMRTQLEELEDEL---------QATEDAKLRLEVNMQAM 1572
Query: 1261 VKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRG 1320
Q + +Q R E E++ + E + E+ E R+
Sbjct: 1573 KAQFERDLQT-----------RDEQNEEKKRLLIKQVRELEA--EL--------EDERKQ 1611
Query: 1321 STLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVR 1380
LA +S++K + D+KDL+AQ++ ANK + ++R
Sbjct: 1612 RALAVASKKK-----------------------MEIDLKDLEAQIEAANKARDEVIKQLR 1648
Query: 1381 SLSV-TSDYSSSLERPWKLR--------------------------AVGTLEGSSPHSVP 1413
L DY LE R + + E + H+
Sbjct: 1649 KLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQ 1708
Query: 1414 DEDEGWLSD---GTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKL--------- 1461
+ DE L+D + + S L K+ LE+ R++QLE +L + +L
Sbjct: 1709 ERDE--LADEITNSASGKSALLDEKRRLEA---RIAQLEEELEEEQSNMELLNDRFRKTT 1763
Query: 1462 -------AEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFE 1514
AE S K D+ Q R+ L+ K++E G + K T+ + E
Sbjct: 1764 LQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEG---AVKSKFKATISALE 1820
Query: 1515 DLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKL-----STKDHKSEKDQ--AGLEPLAL 1567
+ ++ L Q +E+ A ++L R KL +D + DQ +E
Sbjct: 1821 --AKIGQLEEQLEQEAKER-AAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANA 1877
Query: 1568 R---LSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMD 1624
R L R+L+E E+ E +A R L A + S L + L +
Sbjct: 1878 RMKQLKRQLEEAEE--EATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPIS 1935
Query: 1625 IVSEYTHYEE---KKASPSHSDSIHHSSHSAVLSSKP 1658
S + + + AS SD S S V ++P
Sbjct: 1936 FSSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQP 1972
Score = 44.3 bits (103), Expect = 0.001
Identities = 62/269 (23%), Positives = 109/269 (40%), Gaps = 33/269 (12%)
Query: 1866 DRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREH 1925
+ L+ +LE L +TA + ++ + + +L + L E+ + +AQ+ + + H
Sbjct: 1149 EALKTELEDTLDTTA----AQQELRTKREQEVAEL---KKALEEETKNHEAQIQDMRQRH 1201
Query: 1926 SQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQEND 1985
+ E L E L ++ LEK + + + ++L +++ QQ +R L
Sbjct: 1202 ATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQV 1261
Query: 1986 SRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNS-KKGLK----AYSLDACHQ--- 2037
L K+ + E + LQ+EL L + KKG+K A SL++ Q
Sbjct: 1262 QELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQ 1321
Query: 2038 ----------IPLSSDLSHLVAEVRALRGQLEQSIQGNNCLR---LQLQQQLESGAGKAS 2084
+ LSS + L E +L+ Q E+ + L L LQ QL K
Sbjct: 1322 ELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVD 1381
Query: 2085 LSPSSINQNFPASTDPGNKQLLLQDSAVS 2113
+I S + K+LL A+S
Sbjct: 1382 DDLGTIE-----SLEEAKKKLLKDAEALS 1405
Score = 42.4 bits (98), Expect = 0.005
Identities = 44/249 (17%), Positives = 113/249 (45%), Gaps = 24/249 (9%)
Query: 1845 EEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNEN 1904
+E L +++ + ++E + +R +QL A + + +++ E +L +
Sbjct: 858 DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKK 917
Query: 1905 RVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDL 1964
+ L E L++++ E + + L+ ++H+Q+LE++L+ ++ RQ+L +
Sbjct: 918 QELEEILHDLESRVE----EEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEK 973
Query: 1965 REKQQEVLHFREERLSLQENDSR-------LQHKLVLLQQQCEEKQQLFESLQSELQIYE 2017
+ ++ EE L L++ +S+ ++ ++ Q E+++ ++L E
Sbjct: 974 VTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQE 1033
Query: 2018 ALYGNSKKGLK-----AYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQL 2072
+ + ++ LK L+ + L + + L ++ L+ Q+++ L+LQL
Sbjct: 1034 VMISDLEERLKKEEKTRQELEKAKR-KLDGETTDLQDQIAELQAQIDE-------LKLQL 1085
Query: 2073 QQQLESGAG 2081
++ E G
Sbjct: 1086 AKKEEELQG 1094
Score = 40.4 bits (93), Expect = 0.021
Identities = 55/237 (23%), Positives = 105/237 (44%), Gaps = 30/237 (12%)
Query: 1844 LEEHLGEIRNLRQRLE--------ESICINDRLRE---QLEHRLTSTARGRGSTSNFYSQ 1892
LEE L + RQ LE E+ + D++ E Q++ A+ ++
Sbjct: 1039 LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALAR 1098
Query: 1893 GLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEH 1952
G + N +V+RE LQAQ++ + + E S +A R +L +ELE
Sbjct: 1099 GDDETLHKNNALKVVRE----LQAQIAELQEDFESEKASRNKAEKQKR----DLSEELEA 1150
Query: 1953 QKVERQQLLEDLREKQQEVLHFREERL-----SLQENDSRLQHKLV-LLQQQCEEKQQLF 2006
K E + L D QQE+ RE+ + +L+E + ++ + Q+ ++L
Sbjct: 1151 LKTELEDTL-DTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELS 1209
Query: 2007 ESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQ 2063
E L+ + + ++A +K+GL+ + + ++ + L + AE R +L+ +Q
Sbjct: 1210 EQLE-QAKRFKANLEKNKQGLETDNKELACEVKV---LQQVKAESEHKRKKLDAQVQ 1262
Score = 40.0 bits (92), Expect = 0.027
Identities = 57/251 (22%), Positives = 99/251 (39%), Gaps = 30/251 (11%)
Query: 1818 KGSVSGDLSSGSSVYQLNSKPT-GADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRL 1876
K V DL + S+ + K A+ L + L E +LE++ +RL+++L+
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT---KNRLQQELDDLT 1433
Query: 1877 TSTARGRGSTSNFYSQGLESIPQLCNENRV---LREDNRRLQAQLSHVSREHSQETESLR 1933
R SN + + L E + E+ R +A+ +RE + SL
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAE----AREKETKALSLA 1489
Query: 1934 EALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLV 1993
AL E ++E E Q + + +EDL + +V +N L+
Sbjct: 1490 RAL----EEALEAKEEFERQNKQLRADMEDLMSSKDDV----------GKNVHELEKSKR 1535
Query: 1994 LLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSH-----LV 2048
L+QQ EE + E L+ ELQ E + ++A + + + L+
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 2049 AEVRALRGQLE 2059
+VR L +LE
Sbjct: 1596 KQVRELEAELE 1606
Score = 40.0 bits (92), Expect = 0.027
Identities = 48/192 (25%), Positives = 82/192 (42%), Gaps = 28/192 (14%)
Query: 1912 RRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEV 1971
R+LQAQ+ RE + S E S+ E EK+L+ + E QL E+L ++
Sbjct: 1648 RKLQAQMKDYQRELEEARASRDEIFAQSK----ESEKKLKSLEAEILQLQEELASSERAR 1703
Query: 1972 LHFREER--------------LSLQENDSRLQHKLVLLQQQCEEKQQLFESL-----QSE 2012
H +ER +L + RL+ ++ L+++ EE+Q E L ++
Sbjct: 1704 RHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTT 1763
Query: 2013 LQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGN-NCLRL- 2070
LQ+ + + A D Q L L A+++ L G ++ + + L
Sbjct: 1764 LQVDTLNAELAAERSAAQKSDNARQ-QLERQNKELKAKLQELEGAVKSKFKATISALEAK 1822
Query: 2071 --QLQQQLESGA 2080
QL++QLE A
Sbjct: 1823 IGQLEEQLEQEA 1834
Score = 35.8 bits (81), Expect = 0.51
Identities = 33/121 (27%), Positives = 57/121 (47%), Gaps = 5/121 (4%)
Query: 1918 LSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREE 1977
L V+R+ +E ++ E LL + ++E ELE + + QQLLE+ +++ E
Sbjct: 844 LLQVTRQE-EELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETEL 902
Query: 1978 RLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQ 2037
+E +RL K +Q+ EE ES E + + N KK ++A+ D Q
Sbjct: 903 FAEAEEMRARLAAK----KQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958
Query: 2038 I 2038
+
Sbjct: 959 L 959
Score = 33.9 bits (76), Expect = 1.9
Identities = 46/238 (19%), Positives = 94/238 (39%), Gaps = 51/238 (21%)
Query: 1871 QLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETE 1930
QL+ L S+ R R + + I + L ++ RRL+A+++ + E +E
Sbjct: 1691 QLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQS 1750
Query: 1931 SL------------------------REALLSSRSHLQELEKELEHQKVERQQLLEDLRE 1966
++ R A S + Q+LE++ + K + Q+L ++
Sbjct: 1751 NMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKS 1810
Query: 1967 KQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKG 2026
K + + S L+ K+ L++Q E++ + E L ++K
Sbjct: 1811 KFKATI-------------SALEAKIGQLEEQLEQEAK-------ERAAANKLVRRTEKK 1850
Query: 2027 LKAYSL----DACHQIPLSSDLSHLVAEVRALRGQLEQSIQ---GNNCLRLQLQQQLE 2077
LK + + H + A ++ L+ QLE++ + N R +LQ++L+
Sbjct: 1851 LKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELD 1908
Score = 32.7 bits (73), Expect = 4.3
Identities = 16/74 (21%), Positives = 39/74 (52%), Gaps = 4/74 (5%)
Query: 1910 DNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQ 1969
D + L+AQ+ ++ + + LR+ ++ +++ ++ELE + R ++ +E ++
Sbjct: 1625 DLKDLEAQIEAANKARDEVIKQLRKL----QAQMKDYQRELEEARASRDEIFAQSKESEK 1680
Query: 1970 EVLHFREERLSLQE 1983
++ E L LQE
Sbjct: 1681 KLKSLEAEILQLQE 1694
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 138 bits (347), Expect = 7e-32
Identities = 225/1102 (20%), Positives = 469/1102 (42%), Gaps = 120/1102 (10%)
Query: 33 MQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENL------------- 79
M+++++ +++++ K + K E L +Q+K + A+ ENL
Sbjct: 853 MKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKA 912
Query: 80 NSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNL- 138
Q EA+++ E + E E EL K +L E S L K+ L + EKE +
Sbjct: 913 KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 972
Query: 139 -----ELSEKLKGVTKN------------------WEDVPGDQVKPDQYTEALAQRDKRI 175
L+E+L G+ + +D+ ++ K + + ++ ++++
Sbjct: 973 ENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQV 1032
Query: 176 EELNQSLAAQERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSHETTIT 232
E+L SL +++L L R K++L L L +E + ++++ ++L ++ K E
Sbjct: 1033 EDLESSLEQEKKLRVDLERNKRKLEGDLKLAQE-SILDLENDKQQLDERLKKKDFEYCQL 1091
Query: 233 QQSVSD----------------SHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESS 276
Q V D + + EL+E+I+ AT +++ ++ + EL+ E
Sbjct: 1092 QSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERL 1151
Query: 277 QKQDGTIQNLKETLKSRERETEELYQVIEGQN---------------DTMAKLREMLHQS 321
++ G E K RE E +L + +E D++A+L E +
Sbjct: 1152 EEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQI--D 1209
Query: 322 QLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEA 381
L ++ ++ ++ + DL S++ L+++ R E QL++A+ + ++
Sbjct: 1210 NLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQR 1269
Query: 382 AAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNH 441
+ E QK EL + L++ + + S+ +A+ ++ E++ Q + +
Sbjct: 1270 SLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAF-TQQTEELKRQLEEENKAKN 1328
Query: 442 SLSHKEQLLQEFRELL--QYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSAL 499
+L+H Q + +LL QY + + E + L K + E ++ L
Sbjct: 1329 ALAHALQSSRHDCDLLREQYEEEQEGKAEL-QRALSKANSEVAQWRTKYETDAIQRTEEL 1387
Query: 500 EEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQ 559
EE +K+L Q +++ + +E + +S E T Q ++ + ++VE+ ++ L
Sbjct: 1388 EEAKKKLAQ---RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALD 1444
Query: 560 WLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQR 619
+ + + W+ + E +L+ SL KE LS T L KL E ++L +
Sbjct: 1445 KKQRNFDKVLAEWKTKCEESQAELEASL----KESRSLS-TELFKLKNAYEEALDQL-ET 1498
Query: 620 LQRKERMLQDLLSDRNKQVLEHEMEIQGLLQS---VSTREQESQAAAEKLVQALMERNSE 676
++R+ + L+ ++D +Q+ E+ I L +S + + + Q A E+ AL ++
Sbjct: 1499 VKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAK 1558
Query: 677 LQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVS 736
+ ++ L S + + I+ + E+ L + + + S D+ + E +
Sbjct: 1559 ILRIQLELTQVKSEIDR-KIAEKDEEIEQ---LKRNYQRTVETMQSALDAEVRSRNEAIR 1614
Query: 737 IPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMM--AVQ-EEELQVQ 793
+ + GDL+ + E +LS+A + K R Q +L Q + A++ +E+L+ Q
Sbjct: 1615 LKKKMEGDLNEI---EIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQ 1671
Query: 794 AADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISG 853
A +E R + + +++L+ L E A + QE+L E+V + +Q +
Sbjct: 1672 LAIVE---RRANLLQAEVEELRATLEQTE--RARKLAEQELLDSNERVQLLHTQNTSLIH 1726
Query: 854 NRR--QQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQ 911
++ + L+ L+ V++ SR +A AE + ++ E ++++ LE
Sbjct: 1727 TKKKLETDLMQLQSEVEDASR--DARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER-- 1782
Query: 912 VLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVK 971
++ LE+ + RL+ E LA GG E E +E E ++
Sbjct: 1783 -MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGL 1841
Query: 972 VALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQ-------HLEEKRKAE 1024
E+ + + Q+ D LQ ++ + + + HL + RKA+
Sbjct: 1842 RKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQ 1901
Query: 1025 EELKELKAQIEEAGFSSVSHIR 1046
EL+E + + + A S V+ +R
Sbjct: 1902 HELEEAEERADIAE-SQVNKLR 1922
Score = 126 bits (316), Expect = 3e-28
Identities = 233/1115 (20%), Positives = 454/1115 (40%), Gaps = 137/1115 (12%)
Query: 74 ADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAE 133
A+ E + + E ++ +E + EL E + L+QE++ L A L++AE
Sbjct: 844 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE 903
Query: 134 KECN------LELSEKLKGVTKNWEDVPGDQ----VKPDQYTEALAQRDKRIEELNQSLA 183
+ C+ +L K+K VT+ ED K + + ++ K I++L +LA
Sbjct: 904 ERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 963
Query: 184 AQER-----------LVEQLSREKQQLLHLLEEPTSME---VQPMTEELLKQQKLNSHET 229
E+ L E+LS + + L E +++ Q + + ++ K+NS
Sbjct: 964 KVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNK 1023
Query: 230 TITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKET 289
T +S + + +L+ ++Q + L+ ++ +LK AQES + Q L E
Sbjct: 1024 T---KSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDER 1080
Query: 290 LKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSAL- 348
LK ++ E +L +E E T Q Q + +LQ+ +
Sbjct: 1081 LKKKDFEYCQLQSKVE-----------------------DEQTLGLQFQKKIKELQARIE 1117
Query: 349 -FCSQLEIQKLQRVVRQKERQ--LADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQ 405
++E ++ R +K+R + ++ + +E A + Q E + K E K +
Sbjct: 1118 ELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRR 1177
Query: 406 QLQE-ELQNKSQ--QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDN 462
L+E LQ+++ LR A+ E+ Q N+Q + L E+ EF+ + +
Sbjct: 1178 DLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKL---EKEKSEFKLEIDDLSS 1234
Query: 463 SDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLER 522
S +++ ++ LEK+ + + D+ +E +L E + +L+ E LE
Sbjct: 1235 SMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEE 1294
Query: 523 LRDVLS----SNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQES 578
++S S +A Q E L R E + + LQ + + + ++++EQE
Sbjct: 1295 KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEG 1354
Query: 579 IIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQV 638
+LQ +L N EV A K + EE L+ ++ L L D +QV
Sbjct: 1355 -KAELQRALSKANSEV----AQWRTKYETDAIQRTEE----LEEAKKKLAQRLQDSEEQV 1405
Query: 639 LEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISN 698
+ S+ +Q Q E L+ + NS AL + D ++++
Sbjct: 1406 ----EAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAE----- 1456
Query: 699 QQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNA 758
T C Q + + SR ST L ++ L L+TV K L
Sbjct: 1457 -----WKTKCEESQAELEASLKESRSLSTELFKLKNAY--EEALDQLETVKRENKNLEQE 1509
Query: 759 KEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQL 818
+L + ++ EL + + +++ ++Q+ + E+ ++ + K L++QL
Sbjct: 1510 IADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEA-----ALEHEEAKILRIQL 1564
Query: 819 VDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQ 878
LTQ + K+A + + +++ N ++ + M L E NEA++
Sbjct: 1565 ----------ELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIR 1614
Query: 879 AERQLYSSLVKF-----HAHPESSE---RDRTLQVELEGAQVLRSRLEEVLGRSLERLNR 930
++++ L + HA+ +++E R++Q +L+ Q+ L++ L R E L
Sbjct: 1615 LKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQL---HLDDAL-RGQEDLK- 1669
Query: 931 LETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSP 990
E LA + A E T E A + Q+L+ + + + TQN S
Sbjct: 1670 -EQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLD--SNERVQLLHTQNTSLI- 1725
Query: 991 PSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTML 1050
+ + L+ +++ L++E + R AEE+ K+ I +A + +
Sbjct: 1726 ------HTKKKLETDLMQLQSEVEDASRDARNAEEKAKK---AITDAAMMAEELKKEQDT 1776
Query: 1051 SLCLENAELKEQMGEAMSDGWEIEEDKEK-----GEVMVETVVTKEGLSESSLQAEFRKL 1105
S LE +K+ + + + D ++ E+ G+ ++ + T+ E L+ E +K
Sbjct: 1777 SAHLE--RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKN 1834
Query: 1106 QGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLV 1140
+K +KE S ++ + L + LV
Sbjct: 1835 TESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLV 1869
Score = 98.6 bits (244), Expect = 6e-20
Identities = 209/1114 (18%), Positives = 442/1114 (39%), Gaps = 129/1114 (11%)
Query: 341 LLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQEL 400
++ + ++FC Q I+ V +L + + E KE K EL
Sbjct: 805 MVQRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDEL 864
Query: 401 RKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNI----QHLNHSLSHKEQLLQEFREL 456
K+ + ++EL+ K L + + +++ + +N+ + + + K QL + +E+
Sbjct: 865 AKS-EAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEV 923
Query: 457 LQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRER 516
+ ++ + E N L K R ++ D+ L++ ID+ L + EKE V+
Sbjct: 924 TERAEDEE---EINAELTAKKR-KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 979
Query: 517 DHDLERLRDVLSS--------NEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETK 568
+L L + ++ EA Q+++ L +A+ +V L+ T L+ E++E+
Sbjct: 980 TEELSGLDETIAKLTREKKALQEAHQQALDDL-QAEEDKVNSLNKTKSKLEQQVEDLESS 1038
Query: 569 FSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKER--- 625
EQE ++L+ L +RNK + L + ++L +RL++K+
Sbjct: 1039 L-----EQE---KKLRVDL-ERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYC 1089
Query: 626 MLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLG 685
LQ + D L+ + +I+ L + E+E +A + +R+ + L +
Sbjct: 1090 QLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEEL-- 1147
Query: 686 GRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDL 745
+ L +++ Q E L K+ + +++ R D T + + +
Sbjct: 1148 -SERLEEAGGVTSTQIE------LNKKREAEFLKL--RRDLEEATLQHEAMVAALRKKHA 1198
Query: 746 DTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNI- 804
D+VA L +++ N + + + K++ E ++E+ L S M E + A++E + R +
Sbjct: 1199 DSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSM----ESVSKSKANLEKICRTLE 1254
Query: 805 -QIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLML 863
Q+ E K+ ++Q E RL E L ++ ES ++S ++
Sbjct: 1255 DQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSK-------- 1306
Query: 864 EGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGR 923
+ + L L+ E + ++L HA S L+ + E Q ++ L+ L +
Sbjct: 1307 QAFTQQTEELKRQLEEENKAKNALA--HALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1364
Query: 924 SLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEE-----------AAHHSHQQLVKV 972
+ + + T ++ E+ + +++ A+ +Q ++
Sbjct: 1365 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQG 1424
Query: 973 ALEKSLATVETQNPSFSPPSPMGGDSNRCLQE---EMLHLRAEFHQHLEEKRKAEEELKE 1029
+E + VE N + + ++ L E + +AE L+E R EL +
Sbjct: 1425 EVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFK 1484
Query: 1030 LKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVT 1089
LK EEA + ++ +L E A+L EQ+ E E+E+ +++ E+ +
Sbjct: 1485 LKNAYEEA-LDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQL 1543
Query: 1090 KEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERI 1149
+E++L+ E + K+ + +K ++ E + ++ +L + T+E +
Sbjct: 1544 ALEEAEAALEHE----EAKILRIQLELTQVKSEIDRKIAEKDEEIE-QLKRNYQRTVETM 1598
Query: 1150 NTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAF-- 1207
+ L + VR R +++ L D ++++ Q +
Sbjct: 1599 QSAL-------------DAEVRS--RNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKH 1643
Query: 1208 --SLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVML----TGESLV 1261
S+ G + + L + +DL+E+L + E E+E+ R L L
Sbjct: 1644 LRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLA 1703
Query: 1262 KQD---------------------SKQIQVDLQDLGYETCGRSENEAEREETTSPECEEH 1300
+Q+ K+++ DL L E S + EE +
Sbjct: 1704 EQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDA 1763
Query: 1301 NSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKD 1360
+ E + E S R + K L+++L + E+ + G + I L I++
Sbjct: 1764 AMMAEELKKEQDTSAHLERMKKNLEQTV-KDLQHRLDEAEQLALKGGKKQIQKLETRIRE 1822
Query: 1361 LKAQLQNANKV-------IQNLKSRVRSLSVTSD 1387
L+ +L+ K ++ + RV+ L+ S+
Sbjct: 1823 LEFELEGEQKKNTESVKGLRKYERRVKELTYQSE 1856
Score = 86.7 bits (213), Expect = 3e-16
Identities = 131/630 (20%), Positives = 268/630 (42%), Gaps = 96/630 (15%)
Query: 30 EERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEA--EL 87
++++ Q+ + S E + N + +E K+ LQ + + L DVE NS A +
Sbjct: 1391 KKKLAQRLQDSEEQVEAVNAKC-ASLEKTKQRLQGEVEDL---MVDVERANSLAAALDKK 1446
Query: 88 RRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGV 147
+R F++ E + E + +++ +ESR E ++ E L+ E +K
Sbjct: 1447 QRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEA----LDQLETVKRE 1502
Query: 148 TKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPT 207
KN E D TE +A+ K I EL +S +Q+ EK + LEE
Sbjct: 1503 NKNLEQEIAD------LTEQIAENGKTIHELEKSR-------KQIELEKADIQLALEEAE 1549
Query: 208 SMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEAT-NKILQEKLNEMS 266
+ + L Q +L ++ I D +AE E+I+Q + + ++ + +
Sbjct: 1550 AALEHEEAKILRIQLELTQVKSEI------DRKIAEKDEEIEQLKRNYQRTVETMQSALD 1603
Query: 267 YELKCAQES---SQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQL 323
E++ E+ +K +G + ++ L R+ E T+ LR + Q +
Sbjct: 1604 AEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAE----------TLKHLRSVQGQLKD 1653
Query: 324 GQLHSSE---GTSPAQQQVALLDLQSALFCSQLE-----IQKLQRVVRQKERQLADAKQC 375
QLH + G ++Q+A+++ ++ L +++E +++ +R + E++L D+ +
Sbjct: 1654 TQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNER 1713
Query: 376 VQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQN 435
VQ + Q + ++L L QLQ E+++ S+ R +E+
Sbjct: 1714 VQLLHT-------QNTSLIHTKKKLETDLMQLQSEVEDASRDAR----------NAEEKA 1756
Query: 436 IQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEK 495
+ + + E+L +E +D S LE++++ + L+ +DE
Sbjct: 1757 KKAITDAAMMAEELKKE-------QDTSAH--------LERMKKNLEQTVKDLQHRLDEA 1801
Query: 496 FS-ALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTT 554
AL+ +K++++L +RE + +LE + + + ++ E ++ + E+
Sbjct: 1802 EQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKN 1861
Query: 555 CQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAE 614
LQ L ++++ K ++++ E +Q L K +L +++IAE
Sbjct: 1862 VLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEE------AEERADIAE 1915
Query: 615 ELCQRLQRKERMLQDLLSDRNKQVLEHEME 644
+L+ K R D S R ++ HE E
Sbjct: 1916 SQVNKLRAKTR---DFTSSR---MVVHESE 1939
Score = 77.8 bits (190), Expect = 1e-13
Identities = 100/438 (22%), Positives = 198/438 (45%), Gaps = 45/438 (10%)
Query: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQ------KYEASREDIYKRNIELKVE 54
+ N Y L +K+EN +L+ I L E++ + + E SR+ I ++++
Sbjct: 1485 LKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLA 1544
Query: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQE 114
+E + L+ ++ + + ++ + S+ + ++ + EE +Q + +E L
Sbjct: 1545 LEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDA 1604
Query: 115 ESRLAKNEAARMAALVEAE-KECNLELS---EKLKGVTKNWEDVPGDQVKPDQYTEALAQ 170
E R ++NEA R+ +E + E ++LS + K+ V G Q+K Q A
Sbjct: 1605 EVR-SRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQG-QLKDTQLHLDDAL 1662
Query: 171 RDKRIEELNQSLAAQERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSH 227
R + E+L + LA ER L E ++L L E + Q + + + Q L++
Sbjct: 1663 RGQ--EDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQ 1720
Query: 228 ETT-ITQQSVSDSHLAELQEKIQQTEATNKILQEKLNE-------MSYELKCAQESSQKQ 279
T+ I + ++ L +LQ +++ + +EK + M+ ELK Q++S
Sbjct: 1721 NTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1780
Query: 280 DGTIQNLKETLKSRERETEELYQV-IEGQNDTMAKL----REM---LHQSQLGQLHSSEG 331
+ +NL++T+K + +E Q+ ++G + KL RE+ L Q S +G
Sbjct: 1781 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKG 1840
Query: 332 TSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKE 391
+++V L QS + + +LQ +V + + ++ K+ A E+++Q
Sbjct: 1841 LRKYERRVKELTYQSEE--DRKNVLRLQDLVDKLQVKVKSYKR-------QAEEADEQAN 1891
Query: 392 ASWKHNQELRKALQQLQE 409
A H + RKA +L+E
Sbjct: 1892 A---HLTKFRKAQHELEE 1906
Score = 70.1 bits (170), Expect = 2e-11
Identities = 223/1176 (18%), Positives = 437/1176 (37%), Gaps = 152/1176 (12%)
Query: 1003 QEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAEL--- 1059
++EM ++ EF + +E K+E + KEL EE + V + L + E+ L
Sbjct: 847 EKEMATMKEEFQKTKDELAKSEAKRKEL----EEKLVTLVQEKNDLQLQVQAESENLLDA 902
Query: 1060 KEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLL 1119
+E+ + + +++E K + + E +E ++ + L A+ RKL+ + I+ L
Sbjct: 903 EERCDQLIKAKFQLEA---KIKEVTERAEDEEEIN-AELTAKKRKLEDECSELKKDIDDL 958
Query: 1120 KEQLVLSSKEGNS-----KLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFP 1174
+ L KE ++ K E L L TI ++ E HQ
Sbjct: 959 ELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQ------------- 1005
Query: 1175 RPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKL 1234
Q+LD + ++++ ++ + Q L S + + ++ + L+ L
Sbjct: 1006 --QALD---DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDL 1060
Query: 1235 LLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCG------------- 1281
L++ ++ N+ ++ E L K+D + Q+ + +T G
Sbjct: 1061 KLAQESILDLENDKQQL-----DERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQAR 1115
Query: 1282 ----RSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLEN-QL 1336
E EAER E + + +E+ + E G ST ++++ E +L
Sbjct: 1116 IEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKL 1175
Query: 1337 GKQEEFRVYGKSENILVLRK----DIKDLKAQLQNANKVIQNLKSRVRSLSVT-SDYSSS 1391
+ E + LRK + +L Q+ N +V Q L+ + D SSS
Sbjct: 1176 RRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSS 1235
Query: 1392 LERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQ 1451
+E K +A + + E LS+ G + ++ L L + S+L+ +
Sbjct: 1236 MESVSKSKA-------NLEKICRTLEDQLSEARGK----NEEIQRSLSELTTQKSRLQTE 1284
Query: 1452 LPKNGLEEKLAEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVK 1511
+ L +L E+ S + Q EL RQ E + L HA + +
Sbjct: 1285 AGE--LSRQLEEKESIVSQLSRSKQAFTQQTEELK--RQLEEENKAKNALA--HALQSSR 1338
Query: 1512 SFEDLLRSNDIDYYLGQS-FREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLS 1570
DLLR + G++ + L++ + + +K T + ++ LE +L+
Sbjct: 1339 HDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEE---LEEAKKKLA 1395
Query: 1571 RELQEKEKVIEVLQAKLDARSLTPSSSHA-----LSDSHRSPSSTSFLSDELEACSDMDI 1625
+ LQ+ E+ +E + AK + T + D R+ S + L D+ + D +
Sbjct: 1396 QRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAAL-DKKQRNFDKVL 1454
Query: 1626 VSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAESNSNP-ISLPTPQNT 1684
T EE +A S S + + K + A + N + T
Sbjct: 1455 AEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLT 1514
Query: 1685 PKEANQAHSGFHFHSIPKLASLPQAPLPSA---PSSFLPFSPTGPLLLGCCETPVVS--- 1738
+ A + K L +A + A + L L + T V S
Sbjct: 1515 EQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEID 1574
Query: 1739 --LAEAQQELQMLQKQLGESASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIEL 1796
+AE +E++ L++ + T+ A A + S + + L I+L
Sbjct: 1575 RKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRN----EAIRLKKKMEGDLNEIEIQL 1630
Query: 1797 GRILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQ 1856
+ + ++ + SV G L + L+ G + L+E L +
Sbjct: 1631 SH-------ANRQAAETLKHLR-SVQGQLKD--TQLHLDDALRGQEDLKEQLAIVERRAN 1680
Query: 1857 RLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQA 1916
L+ + E+L L T R R E + L +N L ++L+
Sbjct: 1681 LLQAEV-------EELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLET 1733
Query: 1917 QLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFRE 1976
L + E + R A E++ + + + E+L+++Q H
Sbjct: 1734 DLMQLQSEVEDASRDARNA-----------EEKAKKAITDAAMMAEELKKEQDTSAHLER 1782
Query: 1977 ERLSLQENDSRLQHKLVLLQQ--------QCEEKQQLFESLQSELQIYEALYGNSKKGLK 2028
+ +L++ LQH+L +Q Q ++ + L+ EL+ + S KGL+
Sbjct: 1783 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLR 1842
Query: 2029 AYSL-----------DACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQL---QQ 2074
Y D + + L + L +V++ + Q E++ + N + Q
Sbjct: 1843 KYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQH 1902
Query: 2075 QLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDS 2110
+LE +A ++ S +N+ + D + ++++ +S
Sbjct: 1903 ELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHES 1938
Score = 32.3 bits (72), Expect = 5.6
Identities = 61/313 (19%), Positives = 118/313 (37%), Gaps = 47/313 (15%)
Query: 1845 EEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNEN 1904
E+ + + + +LE+ + + EQ + R + ESI L N+
Sbjct: 1015 EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDK 1074
Query: 1905 RVLRE-----------------DNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELE 1947
+ L E D + L Q +E E L E + + R+ + E
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTE 1134
Query: 1948 KELEHQKVERQQLLEDLRE------KQQEVLHFRE-ERLSLQEN--DSRLQHKLVL---- 1994
K+ E ++L E L E Q E+ RE E L L+ + ++ LQH+ ++
Sbjct: 1135 KQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALR 1194
Query: 1995 ---------LQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLS 2045
L +Q + Q++ + L+ E ++ + +++ S + + L
Sbjct: 1195 KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLE 1254
Query: 2046 HLVAEVRALRGQLEQSIQGNNCLRLQLQ-------QQLESGAGKASLSPSSINQNFPAST 2098
++E R ++++S+ + +LQ +QLE S S Q F T
Sbjct: 1255 DQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS-QLSRSKQAFTQQT 1313
Query: 2099 DPGNKQLLLQDSA 2111
+ +QL ++ A
Sbjct: 1314 EELKRQLEEENKA 1326
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 137 bits (346), Expect = 9e-32
Identities = 236/1149 (20%), Positives = 478/1149 (41%), Gaps = 142/1149 (12%)
Query: 163 QYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQ 222
Q E +A+ ++ ++ + LAA+ RL E + + Q + L+ ++Q TE + +
Sbjct: 843 QEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQ--LQEQLQAETELCAEAE 900
Query: 223 KLNSHETTITQQSVSDSH-----LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQ 277
+L + T Q+ H + E +E+ Q +A K +Q+ + E+ +L+ + + Q
Sbjct: 901 ELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQ 960
Query: 278 KQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQ---------SQLGQLHS 328
K +Q K T +++ ++ EE ++E QN +AK +++L ++ +
Sbjct: 961 K----LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSK 1016
Query: 329 SEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQ 388
S + + + DL+ L + + Q+L++ R+ E D + ++A E +
Sbjct: 1017 SLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKM 1076
Query: 389 QKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQH--------LN 440
Q K +EL+ AL +++EE K+ L+ K E+ +Q +Q N
Sbjct: 1077 QLA---KKEEELQAALARVEEEAAQKNMALK-----KIRELESQISELQEDLESERASRN 1128
Query: 441 HSLSHKEQLLQEFREL-LQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSAL 499
+ K L +E L + D D T E LR + + L++ ++E+
Sbjct: 1129 KAEKQKRDLGEELEALKTELEDTLDSTAAQQE-----LRSKREQEVNILKKTLEEEAKTH 1183
Query: 500 EEKEKELRQLRL-AVRERDHDLERLRDVLSSNEATMQSMES-----------LLRAKG-- 545
E + +E+RQ AV E LE+ + V ++ E Q++E+ LL+ KG
Sbjct: 1184 EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDS 1243
Query: 546 --------LEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDL 597
++++L + ++ E+ K ++ Q E +++ L S +K +D
Sbjct: 1244 EHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDF 1303
Query: 598 SATLLCKLGPGQSEIAEELCQRLQ--RKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTR 655
SA L +L Q + EE Q+L K + ++D + +Q+ E E L + ++T
Sbjct: 1304 SA-LESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL 1362
Query: 656 EQESQAAAEKLVQAL--MERNSELQA-LRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQ 712
+ +K+ ++ +E E++ L++ L G + + + E T T +
Sbjct: 1363 HAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQEL 1422
Query: 713 TD---------QGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELE 763
D Q + + + E+ +I + D +E L
Sbjct: 1423 DDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLA 1482
Query: 764 LMAKKERESQMELSALQSMMAVQEEELQVQAADM----ESLTRNIQIKEDLIKDLQMQLV 819
++ E + EL L + E+L D+ L ++ + E +++++ QL
Sbjct: 1483 RALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE 1542
Query: 820 DPED-IPAME--RLTQEVLLLREKVA-SVESQGQEISGNRRQQLLL-----MLEGLVDER 870
+ ED + A E +L EV L K + QG++ +++ L+ M L DER
Sbjct: 1543 ELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDER 1602
Query: 871 SRLNEALQAERQLYSSLVKFHAHPESSERDRT--------LQVELEGAQV----LRSRLE 918
+ + A+ A ++L L AH +S+ ++R LQ +++ R+ E
Sbjct: 1603 KQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE 1662
Query: 919 EVLGRSLERLNRLETLAAI-----GGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLV--- 970
E+L ++ E +L+++ A AA + + + + D + +E A+ S + +
Sbjct: 1663 EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALE 1722
Query: 971 -KVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFH---QHLEEKRKAEEE 1026
K LE +A +E + + + D + ++ + + + H ++ A ++
Sbjct: 1723 EKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQ 1782
Query: 1027 L----KELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEV 1082
L KELK +++E + S + ++ +L + A+L+EQ+ E KE+
Sbjct: 1783 LERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLD---------NETKERQAA 1833
Query: 1083 MVETVVTKEGLSESSLQAE-----FRKLQGKLKNAHNIINLLKEQLVLSSKE------GN 1131
+ T++ L + LQ + + + + A + LK QL + +E
Sbjct: 1834 CKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASR 1893
Query: 1132 SKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQ 1191
KL E L T T + +N E+ K + + V R R + D G+ VD
Sbjct: 1894 RKLQRE-LEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGD-GSDEEVDGKA 1951
Query: 1192 LDNQSQPRD 1200
+++P +
Sbjct: 1952 DGAEAKPAE 1960
Score = 113 bits (282), Expect = 3e-24
Identities = 178/868 (20%), Positives = 365/868 (42%), Gaps = 113/868 (13%)
Query: 22 LKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNS 81
L+ +I L+E ++ + ASR K+ +L E+E+LK EL+D LD T A E L S
Sbjct: 1109 LESQISELQEDLESE-RASRNKAEKQKRDLGEELEALKTELEDT---LDSTAAQQE-LRS 1163
Query: 82 QNEAE---LRRQFEE------------RQQETEHVYELLENKIQLLQEESRLAK------ 120
+ E E L++ EE RQ+ ++ V EL E Q + ++ L K
Sbjct: 1164 KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLE 1223
Query: 121 NEAARMA-----------------ALVEAE-KECNLELSEKLKGVTKNWEDVPGDQVKPD 162
NE +A VEA+ +E ++ +E + T+ + V QV+ D
Sbjct: 1224 NERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELD 1283
Query: 163 QYTEALAQRDKRIEELNQSLAAQERLV----EQLSREKQQLLHLLEEPTSMEVQPMT-EE 217
T L+Q D + +L + +A E + E L E +Q L L + +E + + E
Sbjct: 1284 NVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFRE 1343
Query: 218 LLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQ 277
L++++ H Q + + +A++++K++ + + +E ++ +L+ + +
Sbjct: 1344 QLEEEEEAKHNLE-KQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE 1402
Query: 278 KQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPA-- 335
++ L++T ++E ++L ++ Q + L + Q + QL + E T A
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK--QKKFDQLLAEEKTISAKY 1460
Query: 336 ------------QQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAA 383
+++ L L AL + + +L+R+ +Q ++ D V +
Sbjct: 1461 AEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSV 1520
Query: 384 HESEQQKEASWKHNQELRKALQQLQEELQNKSQ-------QLRAWEAEKYNEIRTQEQNI 436
HE E+ K A + +E++ L++L++ELQ L+A +A+ +++ +++
Sbjct: 1521 HELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDE-- 1578
Query: 437 QHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKF 496
S K+QL+++ RE+ ++ K +KL + D LE ID
Sbjct: 1579 ----QSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKD----LEAHIDSAN 1630
Query: 497 SALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQ 556
+E K+LR+L+ +++ +L+ R S E Q+ E+ + K +E E +
Sbjct: 1631 KNRDEAIKQLRKLQAQMKDCMRELDDTR--ASREEILAQAKENEKKLKSMEAEMIQ---- 1684
Query: 557 NLQWLKEEM---ETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIA 613
L+EE+ E + Q+E++ + ++ S +E+ L ++ + E+
Sbjct: 1685 ----LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE-KRRLEARIAQLEEELE 1739
Query: 614 EELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMER 673
EE Q ++ D L N Q+ + ++ E+ E Q L +
Sbjct: 1740 EE-----QGNTELINDRLKKANLQIDQINTDL--------NLERSHAQKNENARQQLERQ 1786
Query: 674 NSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKE 733
N EL+ Q + G +A I+ +A++ L +Q D + + + T K+
Sbjct: 1787 NKELKVKLQEMEGTVKSKYKASITALEAKIAQ---LEEQLDNETKERQAACKQVRRTEKK 1843
Query: 734 DVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQ 793
+ + + + A L+ + ++ E++ E + + EL+
Sbjct: 1844 LKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDA 1903
Query: 794 AADMESLTRNIQIKEDLIKDLQMQLVDP 821
+++ R + ++ ++ + V P
Sbjct: 1904 TETADAMNREVSSLKNKLRRGDLPFVVP 1931
Score = 108 bits (269), Expect = 8e-23
Identities = 214/1122 (19%), Positives = 444/1122 (39%), Gaps = 134/1122 (11%)
Query: 354 EIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQN 413
+++ L +V RQ+E +A ++ V+ E + E +Q + + LQ LQE+LQ
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQ-LQEQLQA 891
Query: 414 KSQ------QLRAWEAEKYNE-----------IRTQEQNIQHLNHSLSHKEQLLQEFREL 456
+++ +LRA K E + +E+ QHL +Q +QE E
Sbjct: 892 ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ 951
Query: 457 LQYRDNSD--------------KTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEK 502
L+ +++ K LE +++LE ++ + LE I E + L E+
Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011
Query: 503 EKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLK 562
E++ + L + + + L + L E Q +E R + LS LQ
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 563 EEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQR 622
E++ + ++ ++E ++ + +++ +N ++ + L ++ Q ++ E R +
Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMALKKI-RELESQISELQEDLESERASR-NK 1129
Query: 623 KERMLQDLLSDRN--KQVLEHEMEIQGLLQSV-STREQESQAAAEKLVQALMERNSELQA 679
E+ +DL + K LE ++ Q + S REQE + L + +++Q
Sbjct: 1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQE 1189
Query: 680 LRQ-------YLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAK 732
+RQ L + + + ++A+ T G+ ++ + + + DS K
Sbjct: 1190 MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK 1249
Query: 733 EDVSI----------PRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSM 782
+ + R D V L+ EL N L K + + SAL+S
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQ 1309
Query: 783 MAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVA 842
+ +E LQ + SL+ ++ ED + QL + E+ A L +++ L +VA
Sbjct: 1310 LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEE--AKHNLEKQIATLHAQVA 1367
Query: 843 SVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRT 902
++ + ++ G LE + + +L + L+ Q + K A+ + +
Sbjct: 1368 DMKKKMEDSVG--------CLETAEEVKRKLQKDLEGLSQRHEE--KVAAYDKLEKTKTR 1417
Query: 903 LQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAA 962
LQ EL+ V + ++ + + L A + E+ ++ E+E
Sbjct: 1418 LQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETK 1477
Query: 963 HHSHQQLVKVALEKSLATVETQNPSF--------SPPSPMGGD------SNRCLQEEMLH 1008
S + ++ A+E+ A +E N F S +G S R L++++
Sbjct: 1478 ALSLARALEEAMEQK-AELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEE 1536
Query: 1009 LRAEFHQHLEEKRKAEEELK---ELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGE 1065
++ + + LE++ +A E+ K E+ Q +A F R+ ++ E K+Q+
Sbjct: 1537 MKTQL-EELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDE------QSEEKKKQLVR 1589
Query: 1066 AMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQA--------------EFRKLQGKLKN 1111
+ + ED+ K M K + L+A + RKLQ ++K+
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649
Query: 1112 AHNIIN---LLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSP-GKHQHQEEGN 1167
++ +E+++ +KE KL + + + ++ EL + K Q Q+E +
Sbjct: 1650 CMRELDDTRASREEILAQAKENEKKLK-----SMEAEMIQLQEELAAAERAKRQAQQERD 1704
Query: 1168 VTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRY 1227
S GA + +L+ + + + G+T+ + +L + +
Sbjct: 1705 ELADEI--ANSSGKGALALEEKRRLEARIAQLE---EELEEEQGNTELINDRLKKANLQI 1759
Query: 1228 QDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEA 1287
+ L L + AQ NE +++ +K+++V LQ++ + +
Sbjct: 1760 DQINTDLNLERS--HAQKNE--------NARQQLERQNKELKVKLQEMEGTVKSKYKASI 1809
Query: 1288 EREETTSPECEEH--NSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVY 1345
E + EE N KE + C + R L + E + +Q + +
Sbjct: 1810 TALEAKIAQLEEQLDNETKE---RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQAD 1866
Query: 1346 GKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSD 1387
S + L++ +++ + + Q AN + L+ + + T+D
Sbjct: 1867 KASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETAD 1908
Score = 90.9 bits (224), Expect = 1e-17
Identities = 231/1196 (19%), Positives = 471/1196 (39%), Gaps = 185/1196 (15%)
Query: 527 LSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESI-IQQLQT 585
L++ + ++ + L+ + + +L T + L + + E + KE+E + +++ Q
Sbjct: 806 LTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMA---KEEELVKVREKQL 862
Query: 586 SLHDRNKEVEDLSATLLCKLGPGQSEI---------AEELCQRLQRKERMLQDLLSDRNK 636
+ +R E+E L + L+ + Q ++ AEEL RL K++ L+++ D
Sbjct: 863 AAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEA 922
Query: 637 QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPI 696
+V E E Q L Q + ++ +Q L E+ E ++ RQ L
Sbjct: 923 RVEEEEERCQHL--------QAEKKKMQQNIQELEEQLEEEESARQKL------------ 962
Query: 697 SNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELS 756
Q +VT L K ++ QI D + L AKE + D +A L+
Sbjct: 963 --QLEKVTTEAKLKKLEEE---QIILEDQNCKL-AKEKKLLE-------DRIAEFTTNLT 1009
Query: 757 NAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQM 816
+E+ + +AK + + + ++ L+ + +E++ Q L + D I +LQ
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 817 QLVDPE-DIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNE 875
Q+ + + + E Q L E+ A+ ++ + Q+ + E L ER+ N+
Sbjct: 1070 QIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNK 1129
Query: 876 ALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLA 935
A + +R L L L+ ELE + +E+ + + +N L+
Sbjct: 1130 AEKQKRDLGEEL-------------EALKTELEDTLDSTAAQQELRSKREQEVNILKKTL 1176
Query: 936 AIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPM- 994
++ + + ++EE A + VK LEK+ T+E + + +
Sbjct: 1177 EEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL 1236
Query: 995 ---GGDSN---RCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEA----------- 1037
GDS + ++ ++ L+ +F++ + + +++ +L+ +++
Sbjct: 1237 LQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKS 1296
Query: 1038 -----GFSSV-SHIRNTMLSLCLENAE-------LKEQMGEAMSDGWEIEEDKEKGEVMV 1084
FS++ S +++T L EN + LK+ E S ++EE++E +
Sbjct: 1297 SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE 1356
Query: 1085 ETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTS 1144
+ + T + ++ + G L+ A + L++ L S+ K+ + T
Sbjct: 1357 KQIATLHA-QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTK 1415
Query: 1145 TIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSL----DLGATFTVDAHQLDNQSQPRD 1200
T + + + HQ Q N+ + Q L + A + + + + +++ ++
Sbjct: 1416 TRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKE 1475
Query: 1201 PGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESL 1260
S +++L + ++++ E L+ S+ V +ELEK + L
Sbjct: 1476 TKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRAL----- 1530
Query: 1261 VKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRG 1320
+Q ++++ L++L E E + T + +L+ M E+ +G
Sbjct: 1531 -EQQVEEMKTQLEEL----------EDELQATEDAKLRLEVNLQAMKAQ----FERDLQG 1575
Query: 1321 STLASSSERKPLENQLGKQE-EFRVYGKSENILV-----LRKDIKDLKAQLQNAN----- 1369
S ++K L Q+ + E E K ++ V L D+KDL+A + +AN
Sbjct: 1576 RDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDE 1635
Query: 1370 ------KVIQNLKSRVRSLSVT-----SDYSSSLERPWKLRA-----------VGTLEGS 1407
K+ +K +R L T + + E KL++ + E +
Sbjct: 1636 AIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERA 1695
Query: 1408 SPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQL-PKNGLEEKLAEELR 1466
+ + DE L+D G A ++ L R++QLE +L + G E + + L+
Sbjct: 1696 KRQAQQERDE--LADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK 1753
Query: 1467 SA---------------SWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVK 1511
A S K ++ Q R+ L+ K++E G + K ++
Sbjct: 1754 KANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEG---TVKSKYKASIT 1810
Query: 1512 SFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKL---------STKDHKSEKDQAGL 1562
+ E + ++ L +E+ A Q+ R KL ++ + KDQA
Sbjct: 1811 ALE--AKIAQLEEQLDNETKERQAACKQV-RRTEKKLKDVLLQVDDERRNAEQYKDQADK 1867
Query: 1563 EPLALR-LSRELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDEL 1617
L+ L R+L+E E+ E +A R L A + S L ++L
Sbjct: 1868 ASTRLKQLKRQLEEAEE--EAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 53.5 bits (127), Expect = 2e-06
Identities = 97/399 (24%), Positives = 163/399 (40%), Gaps = 40/399 (10%)
Query: 1954 KVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSEL 2013
+V RQ+ E++ K++E++ RE++L+ + +RL L Q EK QL E LQ+E
Sbjct: 839 QVSRQE--EEMMAKEEELVKVREKQLAAE---NRLTEMETLQSQLMAEKLQLQEQLQAET 893
Query: 2014 QIY-EALYGNSKKGLKAYSLDA-CHQIPLSSD-----LSHLVAEVRALRG---QLEQSIQ 2063
++ EA ++ K L+ CH + + HL AE + ++ +LE+ ++
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 2064 GNNCLRLQLQQQLESGAGKASLSPSSINQNF--PASTDPGNKQLLLQDSAVSPPVRDVGM 2121
R +LQ LE +A L Q + ++ LL+D
Sbjct: 954 EEESARQKLQ--LEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011
Query: 2122 NSPALVFPSSASSTPGSETPIINRANGLGLDTSPVMKTPPKLEGDATDGSFANKHGRHVI 2181
+ + T + R + KT KLEGD+TD S
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLS---------- 1061
Query: 2182 GHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIHELRSSTSALH 2241
D + L+ QIAE K+ + K +++A + EA + + K I EL S S L
Sbjct: 1062 ---DQIAELQAQIAELKMQLAKKEEELQAALARVEEEA-AQKNMALKKIRELESQISELQ 1117
Query: 2242 HALE-ESASLLTMFWRAALPSTHIPVLPGKVGESTERELL--ELRTKVSKQERLLQST-T 2297
LE E AS + + L ++ ++ + ELR+K ++ +L+ T
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLE 1177
Query: 2298 EHLKNANQQKESMEQ---FIVSQLTRTHDVLKKARTNLE 2333
E K Q + M Q V +L + K+ + NLE
Sbjct: 1178 EEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLE 1216
Score = 50.1 bits (118), Expect = 3e-05
Identities = 156/849 (18%), Positives = 328/849 (38%), Gaps = 136/849 (16%)
Query: 1214 QHLRSQLSQCKQRYQDLQE----------KLLLSEATVFAQANELEKYRVMLTGESLVKQ 1263
QHL+++ + +Q Q+L+E KL L + T A+ +LE+ +++L ++
Sbjct: 932 QHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLA 991
Query: 1264 DSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMV--LMEGLCSEQGRRGS 1321
K++ D + N E EE + + N + M+ L E L E+ +R
Sbjct: 992 KEKKLLED------RIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQE 1045
Query: 1322 TLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRS 1381
R+ LE G + S+ I L+ I +LK QL + +Q +RV
Sbjct: 1046 L---EKTRRKLE---GDSTDL-----SDQIAELQAQIAELKMQLAKKEEELQAALARVEE 1094
Query: 1382 LSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESL 1441
+ ++ L+ + LE + ++DLES
Sbjct: 1095 --------EAAQKNMALKKIRELESQIS-----------------------ELQEDLES- 1122
Query: 1442 IQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQAR-----ELSYLRQKIREGR 1496
+R S+ +A+ K L E+L E L++ + Q + R E++ L++ + E
Sbjct: 1123 -ERASRNKAEKQKRDLGEEL-EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEA 1180
Query: 1497 G-----ICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTK 1551
I + +H++ + E L ++ + L ++ + + +L + L K
Sbjct: 1181 KTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGK 1240
Query: 1552 ---DHKSEKDQAGLEPLALRLSR-ELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSP 1607
+HK +K +A L+ L ++ + E E +V + +++ ++T S + S S +
Sbjct: 1241 GDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLT 1300
Query: 1608 SSTSFLSDELEACSDM---------DIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKP 1658
S L +L+ ++ + ++ E++K S + + + K
Sbjct: 1301 KDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNS--FREQLEEEEEAKHNLEKQ 1358
Query: 1659 SSTSASQGA--KAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKLASLPQAPLPSAPS 1716
+T +Q A K + + L T + ++ + G K+A+ +
Sbjct: 1359 IATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDK-------- 1410
Query: 1717 SFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGESASTVPPASTATLLSNDLEAD 1776
T L + +V L +Q L+K+ + + T + + E D
Sbjct: 1411 ----LEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAE-ERD 1465
Query: 1777 SSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVSGDLSS-----GSSV 1831
+ A+ + L R LE + + + + Q + DL S G SV
Sbjct: 1466 RA----EAEAREKETKALSLARALEEA-MEQKAELERLNKQFRTEMEDLMSSKDDVGKSV 1520
Query: 1832 YQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTST-ARGRGSTSNFY 1890
++L LE+ + E++ + LE+ + + + +LE L + A+
Sbjct: 1521 HELEKSKRA---LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRD 1577
Query: 1891 SQGLESIPQLCNENRVLR---EDNRRLQAQL---------------SHVSREHSQETESL 1932
Q E QL + R + ED R+ ++ +H+ + E++
Sbjct: 1578 EQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAI 1637
Query: 1933 REALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKL 1992
++ L ++ +++ +EL+ + R+++L +E ++++ E + LQE + +
Sbjct: 1638 KQ-LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAK 1696
Query: 1993 VLLQQQCEE 2001
QQ+ +E
Sbjct: 1697 RQAQQERDE 1705
Score = 45.8 bits (107), Expect = 5e-04
Identities = 41/181 (22%), Positives = 86/181 (47%), Gaps = 15/181 (8%)
Query: 1841 ADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQL 1900
A L +H I +L +RL ++ R++LE + + G +++ Q E Q+
Sbjct: 1019 AKLKNKHEAMITDLEERLRRE----EKQRQELEK---TRRKLEGDSTDLSDQIAELQAQI 1071
Query: 1901 CNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQ- 1959
L + LQA L+ V E +Q+ +L++ + S + EL+++LE ++ R +
Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMALKK-IRELESQISELQEDLESERASRNKA 1130
Query: 1960 ------LLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSEL 2013
L E+L + E+ + + QE S+ + ++ +L++ EE+ + E+ E+
Sbjct: 1131 EKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEM 1190
Query: 2014 Q 2014
+
Sbjct: 1191 R 1191
Score = 42.7 bits (99), Expect = 0.004
Identities = 53/235 (22%), Positives = 104/235 (44%), Gaps = 45/235 (19%)
Query: 1866 DRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREH 1925
+ L+ +LE L STA + S+ + + L + L E+ + +AQ+ + ++H
Sbjct: 1142 EALKTELEDTLDSTA----AQQELRSKREQEVNIL---KKTLEEEAKTHEAQIQEMRQKH 1194
Query: 1926 SQETESLREALLSS---RSHLQELEKELEHQKVE------------------RQQLLEDL 1964
SQ E L E L + +++L++ ++ LE+++ E R+++ L
Sbjct: 1195 SQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQL 1254
Query: 1965 REKQQEVLHFREERLSLQENDSRLQHKL----VLLQQQCEEKQQL---FESLQSELQIYE 2017
+E Q + R L + ++LQ +L LL Q + +L F +L+S+LQ +
Sbjct: 1255 QELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQ 1314
Query: 2018 ALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQL 2072
L + ++ LS+ L + E + R QLE+ + + L Q+
Sbjct: 1315 ELLQEENR----------QKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQI 1359
Score = 42.4 bits (98), Expect = 0.005
Identities = 54/256 (21%), Positives = 102/256 (39%), Gaps = 28/256 (10%)
Query: 1850 EIRNLRQRLEESICIND-------RLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCN 1902
++ L QR EE + D RL+++L+ L R S N + + QL
Sbjct: 1393 DLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ-KKFDQLLA 1451
Query: 1903 ENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLE 1962
E + + + + +RE + SL AL +E QK E ++L +
Sbjct: 1452 EEKTISAKYAEERDRAEAEAREKETKALSLARAL-----------EEAMEQKAELERLNK 1500
Query: 1963 DLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGN 2022
R + ++++ +++ + ++ L+ L+QQ EE + E L+ ELQ E
Sbjct: 1501 QFRTEMEDLMSSKDD---VGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLR 1557
Query: 2023 SKKGLKAYSLDACHQIPLSSDLS-----HLVAEVRALRGQLEQSIQGNNCLRLQLQQQLE 2077
+ L+A + + S LV +VR + +LE + + + +++LE
Sbjct: 1558 LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDE-RKQRSMAVAARKKLE 1616
Query: 2078 SGAGKASLSPSSINQN 2093
S N+N
Sbjct: 1617 MDLKDLEAHIDSANKN 1632
Score = 40.8 bits (94), Expect = 0.016
Identities = 45/232 (19%), Positives = 102/232 (43%), Gaps = 18/232 (7%)
Query: 1845 EEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNEN 1904
EE L ++R + E + + L+ QL + + ++ E +L +
Sbjct: 851 EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKK 910
Query: 1905 RVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDL 1964
+ L E L+A++ E + + L+ + ++QELE++LE ++ RQ+L +
Sbjct: 911 QELEEICHDLEARVE----EEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEK 966
Query: 1965 REKQQEVLHFREERLSLQENDSRLQHKLVLLQQQ-------CEEKQQLFESLQSELQIYE 2017
+ ++ EE++ L++ + +L + LL+ + E+++ +SL +E
Sbjct: 967 VTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHE 1026
Query: 2018 ALYGNSKKGLKAYSLDACHQIPL-------SSDLSHLVAEVRALRGQLEQSI 2062
A+ + ++ L+ S+DLS +AE++A +L+ +
Sbjct: 1027 AMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL 1078
Score = 40.0 bits (92), Expect = 0.027
Identities = 40/198 (20%), Positives = 89/198 (44%), Gaps = 10/198 (5%)
Query: 1844 LEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQ---GLESIPQL 1900
L E L + + ++ LE++ + R +L + + +G+G + + + L+ +
Sbjct: 1201 LAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVK 1260
Query: 1901 CNENRVLREDNR----RLQAQLSHVSREHSQ---ETESLREALLSSRSHLQELEKELEHQ 1953
NE +R + +LQ +L +V+ SQ ++ L + + S LQ+ ++ L+ +
Sbjct: 1261 FNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE 1320
Query: 1954 KVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSEL 2013
++ L L++ + E FRE+ +E L+ ++ L Q + ++ E L
Sbjct: 1321 NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCL 1380
Query: 2014 QIYEALYGNSKKGLKAYS 2031
+ E + +K L+ S
Sbjct: 1381 ETAEEVKRKLQKDLEGLS 1398
Score = 38.9 bits (89), Expect = 0.060
Identities = 36/118 (30%), Positives = 60/118 (50%), Gaps = 20/118 (16%)
Query: 1912 RRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDL------- 1964
R+LQAQ+ RE +T + RE +L+ +E EK+L+ + E QL E+L
Sbjct: 1641 RKLQAQMKDCMRE-LDDTRASREEILAQA---KENEKKLKSMEAEMIQLQEELAAAERAK 1696
Query: 1965 REKQQEVLHFREE--------RLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQ 2014
R+ QQE +E L+L+E RL+ ++ L+++ EE+Q E + L+
Sbjct: 1697 RQAQQERDELADEIANSSGKGALALEEK-RRLEARIAQLEEELEEEQGNTELINDRLK 1753
Score = 36.2 bits (82), Expect = 0.39
Identities = 39/168 (23%), Positives = 77/168 (45%), Gaps = 12/168 (7%)
Query: 1833 QLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQL-EHRLTSTARGRGSTSNFYS 1891
Q++ T +L H + N RQ+LE N L+ +L E T ++ + S + +
Sbjct: 1758 QIDQINTDLNLERSHAQKNENARQQLERQ---NKELKVKLQEMEGTVKSKYKASITALEA 1814
Query: 1892 QGLESIPQLCNENRV-------LREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQ 1944
+ + QL NE + +R ++L+ L V E + E ++ + + L+
Sbjct: 1815 KIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDER-RNAEQYKDQADKASTRLK 1873
Query: 1945 ELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKL 1992
+L+++LE + E Q+ R+ Q+E+ E ++ S L++KL
Sbjct: 1874 QLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 35.0 bits (79), Expect = 0.87
Identities = 51/246 (20%), Positives = 95/246 (38%), Gaps = 36/246 (14%)
Query: 1844 LEEHLGEIRNLRQRLE-ESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCN 1902
LEE L E + RQ+L+ E + +L++ E ++ L +
Sbjct: 948 LEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQII----------------------LED 985
Query: 1903 ENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSH---LQELEKELEHQKVERQQ 1959
+N L ++ + L+ +++ + ++E E + H + +LE+ L ++ +RQ+
Sbjct: 986 QNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQE 1045
Query: 1960 LLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEAL 2019
LE R K + L + + LQ ++ L+ Q +K+ E LQ+ L E
Sbjct: 1046 -LEKTRRK------LEGDSTDLSDQIAELQAQIAELKMQLAKKE---EELQAALARVEEE 1095
Query: 2020 YGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESG 2079
LK L DL A Q + L+ +L+ L+S
Sbjct: 1096 AAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDST 1155
Query: 2080 AGKASL 2085
A + L
Sbjct: 1156 AAQQEL 1161
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 136 bits (343), Expect = 2e-31
Identities = 208/968 (21%), Positives = 411/968 (42%), Gaps = 177/968 (18%)
Query: 10 QHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHL 69
+ + DL+ + LK+++ EE +Q ++I ++N LK ++ L+ + D ++ L
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDL 1134
Query: 70 DKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAAL 129
D A ++N+AE +Q + +E E + LE+ + + L + L
Sbjct: 1135 DSERA------ARNKAE--KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1186
Query: 130 VEA-EKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKR---IEELNQSLAAQ 185
+A ++E ++ + K+ + V + +Q+ A A DK +E+ N LA +
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245
R+ L + KQ++ H K++KL ++ + ELQ
Sbjct: 1247 LRV---LGQAKQEVEH------------------KKKKL-------------EAQVQELQ 1272
Query: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE---TLKSRERETEELYQ 302
K E L +K++++ E++ + +G L + +L S+ ++T+EL
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL- 1331
Query: 303 VIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVV 362
Q +T KL QL + +S LQ L Q L+R +
Sbjct: 1332 ----QEETRQKLNVSTKLRQLEEERNS--------------LQDQLDEEMEAKQNLERHI 1373
Query: 363 RQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQE------ELQNKSQ 416
QL+D+K+ +Q + E+ K+ + +E+ QQ +E +L+
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKK---RFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 417 QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL-LQYRDNSDKT-LEANEMLL 474
+L+ + ++ Q Q + +L +QLL E + + +Y D D+ EA E
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-- 1488
Query: 475 EKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSN---- 530
KA++L RA++E A EE E+ + L+ + DL +D + N
Sbjct: 1489 -------ETKALSLARALEEALEAKEELERTNKMLKAEM----EDLVSSKDDVGKNVHEL 1537
Query: 531 EATMQSMESLLRAKGLEVEQLSTTCQ-----------NLQWLKEEMETKFSRWQKEQESI 579
E + +++E+ + ++E+L Q N+Q LK + E ++ E
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 580 IQQLQTSLHDRNKEVED------LSATLLCKLG--------------PGQSEIAEELCQR 619
+QLQ LH+ E+ED L+A KL G+ E ++L ++
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL-RK 1656
Query: 620 LQRK----ERMLQDLLSDRNK---QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALME 672
LQ + +R L+D + R++ E+E + + L + +++ AA QA +E
Sbjct: 1657 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716
Query: 673 RNSELQALRQYLGGRDSLMS-----QAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDST 727
+ + L L GR++L +A I+ + E+ + +QG+M+ S
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL--------EEEQGNMEAMSDRVRK 1768
Query: 728 SLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQME------------ 775
+ E +S +L T ++ +A+++LE K+ R E
Sbjct: 1769 ATQQAEQLS------NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822
Query: 776 LSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAM-----ERL 830
++AL++ +A EE+++ +A + ++ T++++ K+ +K++ +Q+ D + E+
Sbjct: 1823 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG 1882
Query: 831 TQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKF 890
V L+ ++ E + Q I+ NRR+ L+ +DE + NEA+ E S ++
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRK-----LQRELDEATESNEAMGREVNALKSKLRG 1937
Query: 891 HAHPESSE 898
E+S+
Sbjct: 1938 PPPQETSQ 1945
Score = 135 bits (340), Expect = 5e-31
Identities = 233/1110 (20%), Positives = 456/1110 (41%), Gaps = 135/1110 (12%)
Query: 54 EVESLKRELQ---DKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQ 110
E+++ + ELQ +++Q + ++E +SQ E E+ Q ETE E E +++
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 111 LLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQ 170
L ++ L + M A +E E++ +L + K + + D+ +Q++ ++ Q
Sbjct: 920 LAAKKQEL-EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE-EQLEEEEAARQKLQ 977
Query: 171 RDK-----RIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKL- 224
+K +I++L + + +LS+E++ LLEE S + EE K + L
Sbjct: 978 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERK----LLEERISDLTTNLAEEEEKAKNLT 1033
Query: 225 ---NSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDG 281
N HE+ I+ EL+ ++++ E + + L++ ++ + E
Sbjct: 1034 KLKNKHESMIS----------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 282 TIQNLKETLKSRERETE----ELYQVIEGQNDTMAKLREML-HQSQLGQLHSSEGTSPAQ 336
I LK L +E E + L I +N+ + K+RE+ H S L + SE + +
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143
Query: 337 QQVALLDLQSALFCSQLEIQKL------QRVVRQKERQLADAKQCVQFVEAAAHESEQQK 390
+ DL L + E++ Q+ +R K Q + E +HE++ Q
Sbjct: 1144 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ- 1202
Query: 391 EASWKHNQELRKALQQLQE------ELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS 444
E KH Q + + +QL++ L Q L A+ E+R Q Q + H
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 445 HKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHD----------KAVALERAIDE 494
E +QE + + D E N+ + KL+ + KA+ L + +
Sbjct: 1263 KLEAQVQELQS--KCSDGERARAELNDKV-HKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 495 KFSALEEKEKELRQ-------LRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLE 547
S L++ ++ L++ + +R+ + + L+D L Q++E + ++
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 548 VEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----------LQTSLHDRNKEVEDL 597
+ Q+ E +E R+QKE E++ QQ L+ + + +E++DL
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 598 SATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQ 657
L + +L L++K+R LL++ ++ E +E
Sbjct: 1440 VVDL---------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490
Query: 658 ESQAAAEKLVQALMERNSELQALRQYLGG--RDSLMSQAPISNQQAEVTPT-GCLGKQTD 714
++ + A L +AL E EL+ + L D + S+ + E+ + L Q +
Sbjct: 1491 KALSLARALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 715 QGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAG-LEKELSNAKEELELMAKKERESQ 773
+ Q+ +D L A ED + ++ + G E++L E+ E +K R+ Q
Sbjct: 1550 EMKTQLEELED--ELQATEDAKLRLEV--NMQALKGQFERDLQARDEQNE---EKRRQLQ 1602
Query: 774 MELSALQSMMAVQEEELQVQAADMESLTRN-----------IQIKEDLIKDLQMQLVDPE 822
+L ++ + + ++ + AA + L + I+ +E+ IK L+ +
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 823 DIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL-VDERSRLNEALQAE- 880
D +R ++ R+++ + + ++ + + L+ + E L ER+R L+ E
Sbjct: 1663 D---FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1719
Query: 881 --RQLYSSLVKFHAHPESSER--------DRTLQVELEGAQVLRSRLEEVLGRSLERLNR 930
+L SSL +A + R + L+ E + + R+ + ++ + N
Sbjct: 1720 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779
Query: 931 L--ETLAAIGGAAAGDDTEDTSTEFTDSIEE-EAAHHSHQQLVKVALEKSLATVETQNPS 987
L E A +A E + E + E E A S + ALE +A +E Q
Sbjct: 1780 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Query: 988 FSPPSPMGGDS----NRCLQEEMLHLRAE---FHQHLEEKRKAEEELKELKAQIEEAGFS 1040
+ S ++ L+E +L + E Q+ E+ K +K+LK Q+EEA
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Query: 1041 S--VSHIRNTMLSLCLENAELKEQMGEAMS 1068
S ++ R + E E E MG ++
Sbjct: 1900 SQRINANRRKLQRELDEATESNEAMGREVN 1929
Score = 118 bits (296), Expect = 6e-26
Identities = 259/1231 (21%), Positives = 497/1231 (40%), Gaps = 188/1231 (15%)
Query: 173 KRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTIT 232
KR ++L Q L Q L + + +Q +E Q K + + T
Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPL-LQVTRQEEEMQAKEDELQKTKE 873
Query: 233 QQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKS 292
+Q +++ L EL++K Q +LQE+L ++ + + ++ L +
Sbjct: 874 RQQKAENELKELEQKHSQLTEEKNLLQEQL-----------QAETELYAEAEEMRVRLAA 922
Query: 293 RERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQ 352
+++E EE+ +E A+L E + GQ +E AQQ +LDL+ Q
Sbjct: 923 KKQELEEILHEME------ARLEE---EEDRGQQLQAERKKMAQQ---MLDLE-----EQ 965
Query: 353 LEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQ 412
LE ++ R Q E+ A+AK ++ +E + Q N +L K + L+E +
Sbjct: 966 LEEEEAARQKLQLEKVTAEAK--IKKLEDEILVMDDQ-------NNKLSKERKLLEERIS 1016
Query: 413 NKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEM 472
+ + L +E+ ++L + E ++ E L+ + S + LE +
Sbjct: 1017 DLTTNL-----------AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065
Query: 473 LLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR----QLRLAVRERDHDLERLRDVLS 528
LE H++ L+ I E L +KE+EL+ +L + ++++ L+++R++
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125
Query: 529 SNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS--------RWQKEQESII 580
+ ++S A+ +Q + L+ LK E+E R ++EQE +
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 581 QQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLE 640
+ R+ E + + ++ ++ EEL ++L++ +R +L D+NKQ LE
Sbjct: 1186 LKKALDEETRSHEAQ------VQEMRQKHAQAVEELTEQLEQFKRAKANL--DKNKQTLE 1237
Query: 641 HE-MEIQGLLQSVSTREQESQAAAEKL---VQALMERNSELQALRQYLGGRDSLMSQAPI 696
E ++ G L+ + +QE + +KL VQ L + S+ + R L + +
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK--------V 1289
Query: 697 SNQQAEV-TPTGCLGKQTDQG---SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLE 752
Q EV + TG L + + + + S T + R L + LE
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1349
Query: 753 KELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIK 812
+E ++ +++L+ + ++ + +S L ++ +++LQ A+ +E+L E+ K
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL-------EEGKK 1402
Query: 813 DLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSR 872
Q ++ E LTQ+ EK A+ + E + NR QQ L L +D + +
Sbjct: 1403 RFQKEI---------ENLTQQ---YEEKAAAYDK--LEKTKNRLQQELDDLVVDLDNQRQ 1448
Query: 873 LNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEG------AQVLRSRLEEVL--GRS 924
L L+ +++ + L+ + S D + E E A L LEE L
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1508
Query: 925 LERLNRLETLAAIGGAAAGDDT--------------EDTSTEFTDSIEEEAAHHSHQQLV 970
LER N++ ++ DD E E +EE +
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568
Query: 971 KVALEKSLATVETQ-NPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKE 1029
K+ LE ++ ++ Q + R LQ ++ E +++ A K+
Sbjct: 1569 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628
Query: 1030 LKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVT 1089
L+ +++ + S I+ ++ +L++ + E+E+ + + + T
Sbjct: 1629 LEGDLKDLELQADSAIKGREEAI----KQLRKLQAQMKDFQRELEDARASRDEIFATAKE 1684
Query: 1090 KEGLSESSLQAEFRKLQGKL---KNAHNIINLLKEQL---VLSSKEGNSKLTPELLVHLT 1143
E ++ SL+A+ +LQ L + A +L KE+L + SS G + L E L
Sbjct: 1685 NEKKAK-SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR-RLE 1742
Query: 1144 STIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGP 1203
+ I ++ EL +E+GN+ D T A QL N+
Sbjct: 1743 ARIAQLEEEL--------EEEQGNMEAMS-------DRVRKATQQAEQLSNELATERSTA 1787
Query: 1204 QSAFS----LPGSTQHLRSQL--------SQCKQRYQDLQEKLLLSEATVFAQANELEKY 1251
Q S L + LRS+L S+ K L+ K+ E V +A E +
Sbjct: 1788 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ-- 1845
Query: 1252 RVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNS-LKEMVLME 1310
+SL ++D K ++ LQ E+E + E + E+ N+ +K++
Sbjct: 1846 ---AATKSLKQKDKKLKEILLQ---------VEDERKMAEQYKEQAEKGNARVKQLKRQL 1893
Query: 1311 GLCSEQGRRGSTLASSSERKPLENQLGKQEE 1341
E+ +R ++ R+ L+ +L + E
Sbjct: 1894 EEAEEESQR-----INANRRKLQRELDEATE 1919
Score = 79.0 bits (193), Expect = 5e-14
Identities = 118/570 (20%), Positives = 241/570 (42%), Gaps = 70/570 (12%)
Query: 7 TLSQHLNDLKKENFSLKLRIYFLEE----------RMQQKYE---ASREDIYKRNIELKV 53
TL+ L+D KK+ + LEE + Q+YE A+ + + K L+
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434
Query: 54 EVESLKRELQDKKQ----------HLDKTWADVENLNSQNEAEL-RRQFEERQQETE--H 100
E++ L +L +++Q D+ A+ +N++S+ E R + E R++ET+
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494
Query: 101 VYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNL---ELSEKLKGVTKNWEDVPGD 157
+ LE ++ +E R K A M LV ++ + EL + + + E++
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 158 QVKPDQYTEALAQRDKRIE--------ELNQSLAAQERLVEQLSREKQQLLHLLEEPTSM 209
+ + +A R+E + + L A++ E+ R+ Q+ LH E
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Query: 210 EVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYEL 269
E + ++KL + Q+ DS + +E I+Q LQ ++ + EL
Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDLELQA--DSAIKGREEAIKQLRK----LQAQMKDFQREL 1668
Query: 270 KCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQ--LH 327
+ A+ S + T + ++ KS E + +L + + A+ + L + +L +
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE--RARKQADLEKEELAEELAS 1726
Query: 328 SSEGTSPAQQQVALLDLQSALFCSQLE-----IQKLQRVVRQKERQLADAKQCVQFVEAA 382
S G + Q + L+ + A +LE ++ + VR+ +Q + +
Sbjct: 1727 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1786
Query: 383 AHESEQQKEASWKHNQELRKALQQLQEELQNKSQQ----LRAWEAEKYNEIRTQEQNIQH 438
A ++E ++ + N+ELR L +++ +++K + L A A+ ++ + + Q
Sbjct: 1787 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1846
Query: 439 LNHSLSHKEQLLQEF--------RELLQYRDNSDKTLEANEMLLEKLR------QRIHDK 484
SL K++ L+E + QY++ ++K + L +L QRI+
Sbjct: 1847 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906
Query: 485 AVALERAIDEKFSALEEKEKELRQLRLAVR 514
L+R +DE + E +E+ L+ +R
Sbjct: 1907 RRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 63.9 bits (154), Expect = 2e-09
Identities = 224/1231 (18%), Positives = 446/1231 (36%), Gaps = 187/1231 (15%)
Query: 832 QEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFH 891
+E + +E + Q+ + N ++L L +E++ L E LQAE +LY+ +
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 892 AHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTST 951
+ +++ L L E+ R E +R + L A A
Sbjct: 918 VRLAAKKQE------------LEEILHEMEARLEEEEDRGQQLQAERKKMA-----QQML 960
Query: 952 EFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRA 1011
+ + +EEE A QL KV E + +E + + + L+E + L
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 1012 EFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGW 1071
+L E+ + + L +LK + E S +S + + EL++ + D
Sbjct: 1021 ----NLAEEEEKAKNLTKLKNKHE----SMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072
Query: 1072 EIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKE--------QL 1123
+ E + + + + E LQA +L ++ +N + ++E Q
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132
Query: 1124 VLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGA 1183
L S+ + L +E + TEL + Q+E R Q +
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK-----REQEV---- 1183
Query: 1184 TFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFA 1243
TV LD +++ + Q +R + +Q + + E+ ++A +
Sbjct: 1184 --TVLKKALDEETRSHE----------AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231
Query: 1244 QANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSL 1303
LEK L GE V +KQ E++ ++ E E
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQ--------------EVEHKKKKLEAQVQE------- 1270
Query: 1304 KEMVLMEGLCSEQGRRGSTLASSSER--KPLENQLGKQEEFRVYGKSENILVLRKDIKDL 1361
++ CS+ R + L + +E+ G E GK+ + L KD+ L
Sbjct: 1271 -----LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE--GKA---IKLAKDVASL 1320
Query: 1362 KAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLS 1421
+QLQ+ +++Q + ++S KLR + S + +E
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVST------------KLRQLEEERNSLQDQLDEE------ 1362
Query: 1422 DGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQ 1481
++AK++LE + +S L QL + ++KL + + ++L + +
Sbjct: 1363 ----------MEAKQNLE---RHISTLNIQLSDS--KKKLQD------FASTVEALEEGK 1401
Query: 1482 AR---ELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGS 1538
R E+ L Q+ E + + + +DL+ D L + ++ +
Sbjct: 1402 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1461
Query: 1539 QLT---ERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPS 1595
QL + ++SK + + ++E + E AL L+R L+E L+AK +
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE------ALEAKEELERTNKM 1515
Query: 1596 SSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLS 1655
+ D S ELE + T EE K + ++ A L
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKR----ALETQMEEMKTQLEELEDELQATEDAKLR 1571
Query: 1656 SKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKLASLPQAPLPSAP 1715
+ + Q K + + + QN K Q H + Q L +A
Sbjct: 1572 LEVNM----QALKGQFERD-LQARDEQNEEKR-RQLQRQLHEYETELEDERKQRALAAAA 1625
Query: 1716 SSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGESASTVPPASTATLLSNDLEA 1775
L L ++ + EA ++L+ LQ Q+ + + D A
Sbjct: 1626 KKKLEGDLKDLELQA--DSAIKGREEAIKQLRKLQAQMKDFQREL----------EDARA 1673
Query: 1776 DSSYYLNSAQPHSPPRGTIE--LGRILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQ 1833
+A+ + ++E L ++ E D+ ++ DL +
Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQE----------DLAAAERARKQADLEKEELAEE 1723
Query: 1834 LNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQG 1893
L S +G + L++ + +LEE + E + R+ + SN +
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Query: 1894 LESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQ 1953
+ + + + L N+ L+++L + + +S AL + + +LE+++E +
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL---EAKIAQLEEQVEQE 1840
Query: 1954 KVERQQLLEDLREKQQE----VLHFREERLSLQENDSRLQHKLVLLQQ------QCEEKQ 2003
E+Q + L++K ++ +L +ER ++ + + ++Q + EE+
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900
Query: 2004 QLFESLQSELQ--IYEALYGNSKKGLKAYSL 2032
Q + + +LQ + EA N G + +L
Sbjct: 1901 QRINANRRKLQRELDEATESNEAMGREVNAL 1931
Score = 42.7 bits (99), Expect = 0.004
Identities = 53/239 (22%), Positives = 94/239 (39%), Gaps = 7/239 (2%)
Query: 1844 LEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNE 1903
L+E L R R + E+ L E+LE T ST+ + ++
Sbjct: 1130 LQEDLDSERAARNKAEKQ---KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1186
Query: 1904 NRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLED 1963
+ L E+ R +AQ+ + ++H+Q E L E L + L+K + + E L +
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 1964 LREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNS 2023
LR Q ++ L+ LQ K ++ E LQ+E++ + +
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 2024 K-KGLKAYSLDACHQIPLSSDLSHLVAEVRA---LRGQLEQSIQGNNCLRLQLQQQLES 2078
+ K +K A L L E R + +L Q + N L+ QL +++E+
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365
Score = 42.7 bits (99), Expect = 0.004
Identities = 42/208 (20%), Positives = 87/208 (41%), Gaps = 20/208 (9%)
Query: 1909 EDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQ 1968
ED R + ++ ++E+ ++ +SL L+ + L E+ + +E+++L E+L
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 1969 QEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLK 2028
R +LQ+ RL+ ++ L+++ EE+Q E++ ++ L
Sbjct: 1729 SG-------RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 2029 AYSLDACHQIPLSSDLSHLVAEVR--------ALRGQLEQSIQGNNCLRLQLQQQLESGA 2080
A L E+R A++ + + +I QL++Q+E A
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 2081 GKASLSPSSINQNFPASTDPGNKQLLLQ 2108
+ + S+ Q D K++LLQ
Sbjct: 1842 REKQAATKSLKQK-----DKKLKEILLQ 1864
Score = 42.0 bits (97), Expect = 0.007
Identities = 61/241 (25%), Positives = 94/241 (39%), Gaps = 56/241 (23%)
Query: 1850 EIRNLRQRLEESICIND-------RLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCN 1902
EI NL Q+ EE D RL+++L+ + R SN + + L
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466
Query: 1903 ENRV---LREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQ 1959
E + ++ R +A+ +RE + SL AL + +ELE+ + K E
Sbjct: 1467 EKNISSKYADERDRAEAE----AREKETKALSLARALEEALEAKEELERTNKMLKAE--- 1519
Query: 1960 LLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEAL 2019
+EDL + +V +N L+ L+ Q EE + E L+ ELQ E
Sbjct: 1520 -MEDLVSSKDDV----------GKNVHELEKSKRALETQMEEMKTQLEELEDELQATE-- 1566
Query: 2020 YGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQG----NNCLRLQLQQQ 2075
DA L ++AL+GQ E+ +Q N R QLQ+Q
Sbjct: 1567 -------------DA---------KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604
Query: 2076 L 2076
L
Sbjct: 1605 L 1605
Score = 38.9 bits (89), Expect = 0.060
Identities = 45/240 (18%), Positives = 104/240 (43%), Gaps = 25/240 (10%)
Query: 1845 EEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNEN 1904
E+ L + + +Q+ E + ++ QL + + Y++ E +L +
Sbjct: 865 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 924
Query: 1905 RVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDL 1964
+ L E ++A+L + Q+ ++ R+ + + +LE++LE ++ RQ+L +
Sbjct: 925 QELEEILHEMEARLEE-EEDRGQQLQAERKKMAQQ---MLDLEEQLEEEEAARQKLQLEK 980
Query: 1965 REKQQEVLHFREERLSLQENDSRLQHKLVLLQQQC----------EEK-------QQLFE 2007
+ ++ +E L + + +++L + LL+++ EEK + E
Sbjct: 981 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
Query: 2008 SLQSELQIYEALYGNSKKGLKAYSL----DACHQIPLSSDLSHLVAEVRALRGQLEQSIQ 2063
S+ SEL++ S++ L+ DA +DL +AE++ + E+ +Q
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1100
Score = 37.4 bits (85), Expect = 0.17
Identities = 51/239 (21%), Positives = 100/239 (41%), Gaps = 24/239 (10%)
Query: 1850 EIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLRE 1909
++ +L ++LEE +L QLE ++T+ A+ + + I + ++N L +
Sbjct: 958 QMLDLEEQLEEEEAARQKL--QLE-KVTAEAKIKKLE--------DEILVMDDQNNKLSK 1006
Query: 1910 DNRRLQAQLSHVSREHSQETESLREALLSSRSH---LQELEKELEHQKVERQQLLEDLRE 1966
+ + L+ ++S ++ ++E E + H + ELE L+ ++ RQ+L + R+
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1066
Query: 1967 KQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKG 2026
+ + F E+ LQ ++ L+ Q +K+ E LQ+ L +
Sbjct: 1067 LEGDASDFHEQIADLQA-------QIAELKMQLAKKE---EELQAALARLDDEIAQKNNA 1116
Query: 2027 LKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASL 2085
LK H L DL A Q + L+ +L+ L+S A + L
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1175
Score = 37.4 bits (85), Expect = 0.17
Identities = 50/280 (17%), Positives = 108/280 (38%), Gaps = 19/280 (6%)
Query: 1833 QLNSKPTGADLLEEHLGEIRNLRQRLEESI-CINDRLREQLEHRLTSTARGRGSTSNFYS 1891
Q+ T + LE+ L + + RLE ++ + + L+ R R
Sbjct: 1547 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606
Query: 1892 QGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSR---SHLQELEK 1948
+ + + + ++L+ L + + + EA+ R + +++ ++
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666
Query: 1949 ELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFES 2008
ELE + R ++ +E +++ + + LQE+ + + +Q EK++L E
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER---ARKQADLEKEELAEE 1723
Query: 2009 LQSELQIYEALYGNSKKGLKAYSLDACHQI-PLSSDLSHLVAEVRALRGQLEQ------- 2060
L S L AL + K+ L+A ++ ++ + VR Q EQ
Sbjct: 1724 LASSLSGRNALQ-DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1782
Query: 2061 ---SIQGNNCLRLQLQQQLESGAGKASLSPSSINQNFPAS 2097
+ Q N R QL++Q + K ++ F ++
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822
Score = 32.0 bits (71), Expect = 7.3
Identities = 36/204 (17%), Positives = 78/204 (38%), Gaps = 3/204 (1%)
Query: 1873 EHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLRED---NRRLQAQLSHVSREHSQET 1929
E L T + N + + QL E +L+E L A+ + + +
Sbjct: 865 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 924
Query: 1930 ESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQ 1989
+ L E L + L+E E + + ER+++ + + + ++++ R LQ +
Sbjct: 925 QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 984
Query: 1990 HKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVA 2049
K+ L+ + L E ++ E + L A + L + +++
Sbjct: 985 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1044
Query: 2050 EVRALRGQLEQSIQGNNCLRLQLQ 2073
E+ + E+S Q L+ +L+
Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKLE 1068
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 136 bits (343), Expect = 2e-31
Identities = 208/968 (21%), Positives = 411/968 (42%), Gaps = 177/968 (18%)
Query: 10 QHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHL 69
+ + DL+ + LK+++ EE +Q ++I ++N LK ++ L+ + D ++ L
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDL 1127
Query: 70 DKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAAL 129
D A ++N+AE +Q + +E E + LE+ + + L + L
Sbjct: 1128 DSERA------ARNKAE--KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1179
Query: 130 VEA-EKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKR---IEELNQSLAAQ 185
+A ++E ++ + K+ + V + +Q+ A A DK +E+ N LA +
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245
R+ L + KQ++ H K++KL ++ + ELQ
Sbjct: 1240 LRV---LGQAKQEVEH------------------KKKKL-------------EAQVQELQ 1265
Query: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE---TLKSRERETEELYQ 302
K E L +K++++ E++ + +G L + +L S+ ++T+EL
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL- 1324
Query: 303 VIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVV 362
Q +T KL QL + +S LQ L Q L+R +
Sbjct: 1325 ----QEETRQKLNVSTKLRQLEEERNS--------------LQDQLDEEMEAKQNLERHI 1366
Query: 363 RQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQE------ELQNKSQ 416
QL+D+K+ +Q + E+ K+ + +E+ QQ +E +L+
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKK---RFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 417 QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL-LQYRDNSDKT-LEANEMLL 474
+L+ + ++ Q Q + +L +QLL E + + +Y D D+ EA E
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-- 1481
Query: 475 EKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSN---- 530
KA++L RA++E A EE E+ + L+ + DL +D + N
Sbjct: 1482 -------ETKALSLARALEEALEAKEELERTNKMLKAEM----EDLVSSKDDVGKNVHEL 1530
Query: 531 EATMQSMESLLRAKGLEVEQLSTTCQ-----------NLQWLKEEMETKFSRWQKEQESI 579
E + +++E+ + ++E+L Q N+Q LK + E ++ E
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 580 IQQLQTSLHDRNKEVED------LSATLLCKLG--------------PGQSEIAEELCQR 619
+QLQ LH+ E+ED L+A KL G+ E ++L ++
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL-RK 1649
Query: 620 LQRK----ERMLQDLLSDRNK---QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALME 672
LQ + +R L+D + R++ E+E + + L + +++ AA QA +E
Sbjct: 1650 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709
Query: 673 RNSELQALRQYLGGRDSLMS-----QAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDST 727
+ + L L GR++L +A I+ + E+ + +QG+M+ S
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL--------EEEQGNMEAMSDRVRK 1761
Query: 728 SLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQME------------ 775
+ E +S +L T ++ +A+++LE K+ R E
Sbjct: 1762 ATQQAEQLS------NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815
Query: 776 LSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAM-----ERL 830
++AL++ +A EE+++ +A + ++ T++++ K+ +K++ +Q+ D + E+
Sbjct: 1816 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG 1875
Query: 831 TQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKF 890
V L+ ++ E + Q I+ NRR+ L+ +DE + NEA+ E S ++
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRK-----LQRELDEATESNEAMGREVNALKSKLRG 1930
Query: 891 HAHPESSE 898
E+S+
Sbjct: 1931 PPPQETSQ 1938
Score = 135 bits (340), Expect = 5e-31
Identities = 233/1110 (20%), Positives = 456/1110 (41%), Gaps = 135/1110 (12%)
Query: 54 EVESLKRELQ---DKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQ 110
E+++ + ELQ +++Q + ++E +SQ E E+ Q ETE E E +++
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 111 LLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQ 170
L ++ L + M A +E E++ +L + K + + D+ +Q++ ++ Q
Sbjct: 913 LAAKKQEL-EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE-EQLEEEEAARQKLQ 970
Query: 171 RDK-----RIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKL- 224
+K +I++L + + +LS+E++ LLEE S + EE K + L
Sbjct: 971 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERK----LLEERISDLTTNLAEEEEKAKNLT 1026
Query: 225 ---NSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDG 281
N HE+ I+ EL+ ++++ E + + L++ ++ + E
Sbjct: 1027 KLKNKHESMIS----------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 282 TIQNLKETLKSRERETE----ELYQVIEGQNDTMAKLREML-HQSQLGQLHSSEGTSPAQ 336
I LK L +E E + L I +N+ + K+RE+ H S L + SE + +
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136
Query: 337 QQVALLDLQSALFCSQLEIQKL------QRVVRQKERQLADAKQCVQFVEAAAHESEQQK 390
+ DL L + E++ Q+ +R K Q + E +HE++ Q
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ- 1195
Query: 391 EASWKHNQELRKALQQLQE------ELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS 444
E KH Q + + +QL++ L Q L A+ E+R Q Q + H
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 445 HKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHD----------KAVALERAIDE 494
E +QE + + D E N+ + KL+ + KA+ L + +
Sbjct: 1256 KLEAQVQELQS--KCSDGERARAELNDKV-HKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 495 KFSALEEKEKELRQ-------LRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLE 547
S L++ ++ L++ + +R+ + + L+D L Q++E + ++
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 548 VEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----------LQTSLHDRNKEVEDL 597
+ Q+ E +E R+QKE E++ QQ L+ + + +E++DL
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 598 SATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQ 657
L + +L L++K+R LL++ ++ E +E
Sbjct: 1433 VVDL---------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483
Query: 658 ESQAAAEKLVQALMERNSELQALRQYLGG--RDSLMSQAPISNQQAEVTPT-GCLGKQTD 714
++ + A L +AL E EL+ + L D + S+ + E+ + L Q +
Sbjct: 1484 KALSLARALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542
Query: 715 QGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAG-LEKELSNAKEELELMAKKERESQ 773
+ Q+ +D L A ED + ++ + G E++L E+ E +K R+ Q
Sbjct: 1543 EMKTQLEELED--ELQATEDAKLRLEV--NMQALKGQFERDLQARDEQNE---EKRRQLQ 1595
Query: 774 MELSALQSMMAVQEEELQVQAADMESLTRN-----------IQIKEDLIKDLQMQLVDPE 822
+L ++ + + ++ + AA + L + I+ +E+ IK L+ +
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Query: 823 DIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL-VDERSRLNEALQAE- 880
D +R ++ R+++ + + ++ + + L+ + E L ER+R L+ E
Sbjct: 1656 D---FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1712
Query: 881 --RQLYSSLVKFHAHPESSER--------DRTLQVELEGAQVLRSRLEEVLGRSLERLNR 930
+L SSL +A + R + L+ E + + R+ + ++ + N
Sbjct: 1713 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772
Query: 931 L--ETLAAIGGAAAGDDTEDTSTEFTDSIEE-EAAHHSHQQLVKVALEKSLATVETQNPS 987
L E A +A E + E + E E A S + ALE +A +E Q
Sbjct: 1773 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832
Query: 988 FSPPSPMGGDS----NRCLQEEMLHLRAE---FHQHLEEKRKAEEELKELKAQIEEAGFS 1040
+ S ++ L+E +L + E Q+ E+ K +K+LK Q+EEA
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Query: 1041 S--VSHIRNTMLSLCLENAELKEQMGEAMS 1068
S ++ R + E E E MG ++
Sbjct: 1893 SQRINANRRKLQRELDEATESNEAMGREVN 1922
Score = 118 bits (296), Expect = 6e-26
Identities = 259/1231 (21%), Positives = 497/1231 (40%), Gaps = 188/1231 (15%)
Query: 173 KRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTIT 232
KR ++L Q L Q L + + +Q +E Q K + + T
Sbjct: 808 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPL-LQVTRQEEEMQAKEDELQKTKE 866
Query: 233 QQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKS 292
+Q +++ L EL++K Q +LQE+L ++ + + ++ L +
Sbjct: 867 RQQKAENELKELEQKHSQLTEEKNLLQEQL-----------QAETELYAEAEEMRVRLAA 915
Query: 293 RERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQ 352
+++E EE+ +E A+L E + GQ +E AQQ +LDL+ Q
Sbjct: 916 KKQELEEILHEME------ARLEE---EEDRGQQLQAERKKMAQQ---MLDLE-----EQ 958
Query: 353 LEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQ 412
LE ++ R Q E+ A+AK ++ +E + Q N +L K + L+E +
Sbjct: 959 LEEEEAARQKLQLEKVTAEAK--IKKLEDEILVMDDQ-------NNKLSKERKLLEERIS 1009
Query: 413 NKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEM 472
+ + L +E+ ++L + E ++ E L+ + S + LE +
Sbjct: 1010 DLTTNL-----------AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 473 LLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR----QLRLAVRERDHDLERLRDVLS 528
LE H++ L+ I E L +KE+EL+ +L + ++++ L+++R++
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 529 SNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS--------RWQKEQESII 580
+ ++S A+ +Q + L+ LK E+E R ++EQE +
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 581 QQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLE 640
+ R+ E + + ++ ++ EEL ++L++ +R +L D+NKQ LE
Sbjct: 1179 LKKALDEETRSHEAQ------VQEMRQKHAQAVEELTEQLEQFKRAKANL--DKNKQTLE 1230
Query: 641 HE-MEIQGLLQSVSTREQESQAAAEKL---VQALMERNSELQALRQYLGGRDSLMSQAPI 696
E ++ G L+ + +QE + +KL VQ L + S+ + R L + +
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK--------V 1282
Query: 697 SNQQAEV-TPTGCLGKQTDQG---SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLE 752
Q EV + TG L + + + + S T + R L + LE
Sbjct: 1283 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1342
Query: 753 KELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIK 812
+E ++ +++L+ + ++ + +S L ++ +++LQ A+ +E+L E+ K
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL-------EEGKK 1395
Query: 813 DLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSR 872
Q ++ E LTQ+ EK A+ + E + NR QQ L L +D + +
Sbjct: 1396 RFQKEI---------ENLTQQ---YEEKAAAYDK--LEKTKNRLQQELDDLVVDLDNQRQ 1441
Query: 873 LNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEG------AQVLRSRLEEVL--GRS 924
L L+ +++ + L+ + S D + E E A L LEE L
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1501
Query: 925 LERLNRLETLAAIGGAAAGDDT--------------EDTSTEFTDSIEEEAAHHSHQQLV 970
LER N++ ++ DD E E +EE +
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561
Query: 971 KVALEKSLATVETQ-NPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKE 1029
K+ LE ++ ++ Q + R LQ ++ E +++ A K+
Sbjct: 1562 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1621
Query: 1030 LKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVT 1089
L+ +++ + S I+ ++ +L++ + E+E+ + + + T
Sbjct: 1622 LEGDLKDLELQADSAIKGREEAI----KQLRKLQAQMKDFQRELEDARASRDEIFATAKE 1677
Query: 1090 KEGLSESSLQAEFRKLQGKL---KNAHNIINLLKEQL---VLSSKEGNSKLTPELLVHLT 1143
E ++ SL+A+ +LQ L + A +L KE+L + SS G + L E L
Sbjct: 1678 NEKKAK-SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR-RLE 1735
Query: 1144 STIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGP 1203
+ I ++ EL +E+GN+ D T A QL N+
Sbjct: 1736 ARIAQLEEEL--------EEEQGNMEAMS-------DRVRKATQQAEQLSNELATERSTA 1780
Query: 1204 QSAFS----LPGSTQHLRSQL--------SQCKQRYQDLQEKLLLSEATVFAQANELEKY 1251
Q S L + LRS+L S+ K L+ K+ E V +A E +
Sbjct: 1781 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ-- 1838
Query: 1252 RVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNS-LKEMVLME 1310
+SL ++D K ++ LQ E+E + E + E+ N+ +K++
Sbjct: 1839 ---AATKSLKQKDKKLKEILLQ---------VEDERKMAEQYKEQAEKGNARVKQLKRQL 1886
Query: 1311 GLCSEQGRRGSTLASSSERKPLENQLGKQEE 1341
E+ +R ++ R+ L+ +L + E
Sbjct: 1887 EEAEEESQR-----INANRRKLQRELDEATE 1912
Score = 79.0 bits (193), Expect = 5e-14
Identities = 118/570 (20%), Positives = 241/570 (42%), Gaps = 70/570 (12%)
Query: 7 TLSQHLNDLKKENFSLKLRIYFLEE----------RMQQKYE---ASREDIYKRNIELKV 53
TL+ L+D KK+ + LEE + Q+YE A+ + + K L+
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427
Query: 54 EVESLKRELQDKKQ----------HLDKTWADVENLNSQNEAEL-RRQFEERQQETE--H 100
E++ L +L +++Q D+ A+ +N++S+ E R + E R++ET+
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487
Query: 101 VYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNL---ELSEKLKGVTKNWEDVPGD 157
+ LE ++ +E R K A M LV ++ + EL + + + E++
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 158 QVKPDQYTEALAQRDKRIE--------ELNQSLAAQERLVEQLSREKQQLLHLLEEPTSM 209
+ + +A R+E + + L A++ E+ R+ Q+ LH E
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Query: 210 EVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYEL 269
E + ++KL + Q+ DS + +E I+Q LQ ++ + EL
Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDLELQA--DSAIKGREEAIKQLRK----LQAQMKDFQREL 1661
Query: 270 KCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQ--LH 327
+ A+ S + T + ++ KS E + +L + + A+ + L + +L +
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE--RARKQADLEKEELAEELAS 1719
Query: 328 SSEGTSPAQQQVALLDLQSALFCSQLE-----IQKLQRVVRQKERQLADAKQCVQFVEAA 382
S G + Q + L+ + A +LE ++ + VR+ +Q + +
Sbjct: 1720 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1779
Query: 383 AHESEQQKEASWKHNQELRKALQQLQEELQNKSQQ----LRAWEAEKYNEIRTQEQNIQH 438
A ++E ++ + N+ELR L +++ +++K + L A A+ ++ + + Q
Sbjct: 1780 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1839
Query: 439 LNHSLSHKEQLLQEF--------RELLQYRDNSDKTLEANEMLLEKLR------QRIHDK 484
SL K++ L+E + QY++ ++K + L +L QRI+
Sbjct: 1840 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899
Query: 485 AVALERAIDEKFSALEEKEKELRQLRLAVR 514
L+R +DE + E +E+ L+ +R
Sbjct: 1900 RRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 63.9 bits (154), Expect = 2e-09
Identities = 224/1231 (18%), Positives = 446/1231 (36%), Gaps = 187/1231 (15%)
Query: 832 QEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFH 891
+E + +E + Q+ + N ++L L +E++ L E LQAE +LY+ +
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 892 AHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTST 951
+ +++ L L E+ R E +R + L A A
Sbjct: 911 VRLAAKKQE------------LEEILHEMEARLEEEEDRGQQLQAERKKMA-----QQML 953
Query: 952 EFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRA 1011
+ + +EEE A QL KV E + +E + + + L+E + L
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 1012 EFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGW 1071
+L E+ + + L +LK + E S +S + + EL++ + D
Sbjct: 1014 ----NLAEEEEKAKNLTKLKNKHE----SMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 1072 EIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKE--------QL 1123
+ E + + + + E LQA +L ++ +N + ++E Q
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125
Query: 1124 VLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGA 1183
L S+ + L +E + TEL + Q+E R Q +
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK-----REQEV---- 1176
Query: 1184 TFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFA 1243
TV LD +++ + Q +R + +Q + + E+ ++A +
Sbjct: 1177 --TVLKKALDEETRSHE----------AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224
Query: 1244 QANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSL 1303
LEK L GE V +KQ E++ ++ E E
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAKQ--------------EVEHKKKKLEAQVQE------- 1263
Query: 1304 KEMVLMEGLCSEQGRRGSTLASSSER--KPLENQLGKQEEFRVYGKSENILVLRKDIKDL 1361
++ CS+ R + L + +E+ G E GK+ + L KD+ L
Sbjct: 1264 -----LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE--GKA---IKLAKDVASL 1313
Query: 1362 KAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLS 1421
+QLQ+ +++Q + ++S KLR + S + +E
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVST------------KLRQLEEERNSLQDQLDEE------ 1355
Query: 1422 DGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQ 1481
++AK++LE + +S L QL + ++KL + + ++L + +
Sbjct: 1356 ----------MEAKQNLE---RHISTLNIQLSDS--KKKLQD------FASTVEALEEGK 1394
Query: 1482 AR---ELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGS 1538
R E+ L Q+ E + + + +DL+ D L + ++ +
Sbjct: 1395 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1454
Query: 1539 QLT---ERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPS 1595
QL + ++SK + + ++E + E AL L+R L+E L+AK +
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE------ALEAKEELERTNKM 1508
Query: 1596 SSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLS 1655
+ D S ELE + T EE K + ++ A L
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKR----ALETQMEEMKTQLEELEDELQATEDAKLR 1564
Query: 1656 SKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKLASLPQAPLPSAP 1715
+ + Q K + + + QN K Q H + Q L +A
Sbjct: 1565 LEVNM----QALKGQFERD-LQARDEQNEEKR-RQLQRQLHEYETELEDERKQRALAAAA 1618
Query: 1716 SSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGESASTVPPASTATLLSNDLEA 1775
L L ++ + EA ++L+ LQ Q+ + + D A
Sbjct: 1619 KKKLEGDLKDLELQA--DSAIKGREEAIKQLRKLQAQMKDFQREL----------EDARA 1666
Query: 1776 DSSYYLNSAQPHSPPRGTIE--LGRILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQ 1833
+A+ + ++E L ++ E D+ ++ DL +
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQE----------DLAAAERARKQADLEKEELAEE 1716
Query: 1834 LNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQG 1893
L S +G + L++ + +LEE + E + R+ + SN +
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Query: 1894 LESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQ 1953
+ + + + L N+ L+++L + + +S AL + + +LE+++E +
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL---EAKIAQLEEQVEQE 1833
Query: 1954 KVERQQLLEDLREKQQE----VLHFREERLSLQENDSRLQHKLVLLQQ------QCEEKQ 2003
E+Q + L++K ++ +L +ER ++ + + ++Q + EE+
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893
Query: 2004 QLFESLQSELQ--IYEALYGNSKKGLKAYSL 2032
Q + + +LQ + EA N G + +L
Sbjct: 1894 QRINANRRKLQRELDEATESNEAMGREVNAL 1924
Score = 42.7 bits (99), Expect = 0.004
Identities = 53/239 (22%), Positives = 94/239 (39%), Gaps = 7/239 (2%)
Query: 1844 LEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNE 1903
L+E L R R + E+ L E+LE T ST+ + ++
Sbjct: 1123 LQEDLDSERAARNKAEKQ---KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1179
Query: 1904 NRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLED 1963
+ L E+ R +AQ+ + ++H+Q E L E L + L+K + + E L +
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 1964 LREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNS 2023
LR Q ++ L+ LQ K ++ E LQ+E++ + +
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 2024 K-KGLKAYSLDACHQIPLSSDLSHLVAEVRA---LRGQLEQSIQGNNCLRLQLQQQLES 2078
+ K +K A L L E R + +L Q + N L+ QL +++E+
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358
Score = 42.7 bits (99), Expect = 0.004
Identities = 42/208 (20%), Positives = 87/208 (41%), Gaps = 20/208 (9%)
Query: 1909 EDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQ 1968
ED R + ++ ++E+ ++ +SL L+ + L E+ + +E+++L E+L
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Query: 1969 QEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLK 2028
R +LQ+ RL+ ++ L+++ EE+Q E++ ++ L
Sbjct: 1722 SG-------RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774
Query: 2029 AYSLDACHQIPLSSDLSHLVAEVR--------ALRGQLEQSIQGNNCLRLQLQQQLESGA 2080
A L E+R A++ + + +I QL++Q+E A
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 2081 GKASLSPSSINQNFPASTDPGNKQLLLQ 2108
+ + S+ Q D K++LLQ
Sbjct: 1835 REKQAATKSLKQK-----DKKLKEILLQ 1857
Score = 42.0 bits (97), Expect = 0.007
Identities = 61/241 (25%), Positives = 94/241 (39%), Gaps = 56/241 (23%)
Query: 1850 EIRNLRQRLEESICIND-------RLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCN 1902
EI NL Q+ EE D RL+++L+ + R SN + + L
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459
Query: 1903 ENRV---LREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQ 1959
E + ++ R +A+ +RE + SL AL + +ELE+ + K E
Sbjct: 1460 EKNISSKYADERDRAEAE----AREKETKALSLARALEEALEAKEELERTNKMLKAE--- 1512
Query: 1960 LLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEAL 2019
+EDL + +V +N L+ L+ Q EE + E L+ ELQ E
Sbjct: 1513 -MEDLVSSKDDV----------GKNVHELEKSKRALETQMEEMKTQLEELEDELQATE-- 1559
Query: 2020 YGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQG----NNCLRLQLQQQ 2075
DA L ++AL+GQ E+ +Q N R QLQ+Q
Sbjct: 1560 -------------DA---------KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597
Query: 2076 L 2076
L
Sbjct: 1598 L 1598
Score = 38.9 bits (89), Expect = 0.060
Identities = 45/240 (18%), Positives = 104/240 (43%), Gaps = 25/240 (10%)
Query: 1845 EEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNEN 1904
E+ L + + +Q+ E + ++ QL + + Y++ E +L +
Sbjct: 858 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 917
Query: 1905 RVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDL 1964
+ L E ++A+L + Q+ ++ R+ + + +LE++LE ++ RQ+L +
Sbjct: 918 QELEEILHEMEARLEE-EEDRGQQLQAERKKMAQQ---MLDLEEQLEEEEAARQKLQLEK 973
Query: 1965 REKQQEVLHFREERLSLQENDSRLQHKLVLLQQQC----------EEK-------QQLFE 2007
+ ++ +E L + + +++L + LL+++ EEK + E
Sbjct: 974 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033
Query: 2008 SLQSELQIYEALYGNSKKGLKAYSL----DACHQIPLSSDLSHLVAEVRALRGQLEQSIQ 2063
S+ SEL++ S++ L+ DA +DL +AE++ + E+ +Q
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1093
Score = 37.4 bits (85), Expect = 0.17
Identities = 51/239 (21%), Positives = 100/239 (41%), Gaps = 24/239 (10%)
Query: 1850 EIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLRE 1909
++ +L ++LEE +L QLE ++T+ A+ + + I + ++N L +
Sbjct: 951 QMLDLEEQLEEEEAARQKL--QLE-KVTAEAKIKKLE--------DEILVMDDQNNKLSK 999
Query: 1910 DNRRLQAQLSHVSREHSQETESLREALLSSRSH---LQELEKELEHQKVERQQLLEDLRE 1966
+ + L+ ++S ++ ++E E + H + ELE L+ ++ RQ+L + R+
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1059
Query: 1967 KQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKG 2026
+ + F E+ LQ ++ L+ Q +K+ E LQ+ L +
Sbjct: 1060 LEGDASDFHEQIADLQA-------QIAELKMQLAKKE---EELQAALARLDDEIAQKNNA 1109
Query: 2027 LKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASL 2085
LK H L DL A Q + L+ +L+ L+S A + L
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168
Score = 37.4 bits (85), Expect = 0.17
Identities = 50/280 (17%), Positives = 108/280 (38%), Gaps = 19/280 (6%)
Query: 1833 QLNSKPTGADLLEEHLGEIRNLRQRLEESI-CINDRLREQLEHRLTSTARGRGSTSNFYS 1891
Q+ T + LE+ L + + RLE ++ + + L+ R R
Sbjct: 1540 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599
Query: 1892 QGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSR---SHLQELEK 1948
+ + + + ++L+ L + + + EA+ R + +++ ++
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659
Query: 1949 ELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFES 2008
ELE + R ++ +E +++ + + LQE+ + + +Q EK++L E
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER---ARKQADLEKEELAEE 1716
Query: 2009 LQSELQIYEALYGNSKKGLKAYSLDACHQI-PLSSDLSHLVAEVRALRGQLEQ------- 2060
L S L AL + K+ L+A ++ ++ + VR Q EQ
Sbjct: 1717 LASSLSGRNALQ-DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1775
Query: 2061 ---SIQGNNCLRLQLQQQLESGAGKASLSPSSINQNFPAS 2097
+ Q N R QL++Q + K ++ F ++
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815
Score = 32.0 bits (71), Expect = 7.3
Identities = 36/204 (17%), Positives = 78/204 (38%), Gaps = 3/204 (1%)
Query: 1873 EHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLRED---NRRLQAQLSHVSREHSQET 1929
E L T + N + + QL E +L+E L A+ + + +
Sbjct: 858 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 917
Query: 1930 ESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQ 1989
+ L E L + L+E E + + ER+++ + + + ++++ R LQ +
Sbjct: 918 QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 977
Query: 1990 HKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVA 2049
K+ L+ + L E ++ E + L A + L + +++
Sbjct: 978 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1037
Query: 2050 EVRALRGQLEQSIQGNNCLRLQLQ 2073
E+ + E+S Q L+ +L+
Sbjct: 1038 ELEVRLKKEEKSRQELEKLKRKLE 1061
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 136 bits (342), Expect = 3e-31
Identities = 214/1113 (19%), Positives = 451/1113 (40%), Gaps = 143/1113 (12%)
Query: 33 MQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQN--------- 83
M++ +E ++E++ + K E + LQ+K + ++ ENL
Sbjct: 856 MKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKS 915
Query: 84 ----EAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNL- 138
EA+++ E ++E E EL+ K L + S L ++ L + EKE +
Sbjct: 916 KILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHAT 975
Query: 139 -----ELSEKLKGVTKN------------------WEDVPGDQVKPDQYTEALAQRDKRI 175
LSE++ + +N +D+ ++ K + + A+ +++
Sbjct: 976 ENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQT 1035
Query: 176 EELNQSLAAQERLVEQLSREKQQLLHLLE--EPTSMEVQPMTEELLKQQKLNSHETTITQ 233
++L SL +++L L R K++L L+ + + M+++ +++ ++ K E + Q
Sbjct: 1036 DDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQ 1095
Query: 234 QSVSDS--HLAELQEKIQQTEATNKILQEKL--------------NEMSYELKCAQESSQ 277
+ D H + Q+KI++ +A + L+E++ ++++ EL+ E +
Sbjct: 1096 AKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLE 1155
Query: 278 KQDGTIQNLKETLKSRERETEELYQVIE---------------GQNDTMAKLREMLHQSQ 322
+ G E K RE E +++ + +E Q D++A+L E + Q
Sbjct: 1156 EASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQ 1215
Query: 323 LGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAA 382
+ + S + ++ D+ S + ++R R E Q ++ K +
Sbjct: 1216 RVKQKLEKEKSELKMEID--DMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQL 1273
Query: 383 AHESEQQKEASWKHNQEL-------RKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQN 435
H+ QK N EL + QL + Q +QQL E ++ E T+ +N
Sbjct: 1274 IHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLE--ELKRQMEEETKAKN 1331
Query: 436 -IQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDE 494
+ H S H LL+E QY + + E + L K + E +
Sbjct: 1332 AMAHALQSSRHDCDLLRE-----QYEEEQEAKAEL-QRALSKANSEVAQWRTKYETDAIQ 1385
Query: 495 KFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTT 554
+ LEE +K+L Q ++E + + E +S E T Q ++ + ++E+ T
Sbjct: 1386 RTEELEEAKKKLAQ---RLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA 1442
Query: 555 CQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAE 614
C L + + + W+++ + + Q L KE LS T L K+ E+ +
Sbjct: 1443 CATLDKKQRNFDKVLAEWKQK----LDESQAELEAAQKESRSLS-TELFKMRNAYEEVVD 1497
Query: 615 ELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQES---QAAAEKLVQALM 671
+L + L+R+ + LQ+ +SD +Q+ E +Q ++ EQE Q A E++ +L
Sbjct: 1498 QL-ETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLE 1556
Query: 672 ERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTA 731
S++ ++ L S + + I + E+ L + + + + + S D+ +
Sbjct: 1557 HEESKILRVQLELSQVKSELDRKVIEKDE-EIEQ---LKRNSQRAAEALQSVLDAEIRSR 1612
Query: 732 KEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQ 791
+ + + + GDL+ +E +L ++ ++ E+Q L +Q + + L
Sbjct: 1613 NDALRLKKKMEGDLNE---MEIQLGHSNRQM-------AETQKHLRTVQGQLKDSQLHLD 1662
Query: 792 VQAADMESLTRNIQIKED----LIKDLQMQLVDPEDIPAMERLT-QEVLLLREKVASVES 846
E L + I E L+++L+ V E RL+ QE+L ++V + S
Sbjct: 1663 DALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHS 1722
Query: 847 QGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVE 906
Q + +++ + + + + + E+ AE + ++ E ++++
Sbjct: 1723 QNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1782
Query: 907 LEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAH--- 963
LE ++ LE+ + RL+ E LA GG E+ E + ++ E
Sbjct: 1783 LER---MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAE 1839
Query: 964 -----HSHQQLVK-------------VALEKSLATVETQNPSFSPPSPMGGDSNRCLQEE 1005
H +++ VK + L+ + ++ + S+ + +
Sbjct: 1840 ALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSR 1899
Query: 1006 MLHLRAEFHQHLEEKRKAEEELKELKAQIEEAG 1038
++ E + E AE ++ +L+A+ + G
Sbjct: 1900 CRRVQHELEEAAERADIAESQVNKLRAKSRDVG 1932
Score = 94.4 bits (233), Expect = 1e-18
Identities = 214/1122 (19%), Positives = 442/1122 (39%), Gaps = 160/1122 (14%)
Query: 286 LKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQ 345
+K LKS E E E + + + +E L +S+ + E + V+LL +
Sbjct: 840 IKPLLKSAEAEKE-----MATMKEDFERTKEELARSEARRKELEE------KMVSLLQEK 888
Query: 346 SALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQ 405
+ L QL++Q + E + + +EA E ++ E + N EL +
Sbjct: 889 NDL---QLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKR 945
Query: 406 QLQEELQNKSQQLRAWE---AEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF-RELLQYRD 461
L+++ + + + E + E E +++L+ ++ E+ + + +E ++
Sbjct: 946 NLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQE 1005
Query: 462 NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLE 521
+TL+ ++ +K+ I A LE+ D+ +LE+++K L A R+ + DL+
Sbjct: 1006 AHQQTLDDLQVEEDKVNGLIKINA-KLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLK 1064
Query: 522 RLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQ 581
++ + E Q +E L+ K E+ QL + Q + + K I+
Sbjct: 1065 MSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKK-----------IK 1113
Query: 582 QLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEH 641
+LQ + + +E+E TL K+ +S++A EL
Sbjct: 1114 ELQARIEELEEEIE-AEHTLRAKIEKQRSDLAREL------------------------- 1147
Query: 642 EMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQA 701
+ +S R +E+ A ++ +R +E Q +R+ L +A + ++
Sbjct: 1148 --------EEISERLEEASGATSAQIEMNKKREAEFQKMRRDL-------EEATLQHEAT 1192
Query: 702 EVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLG-DLDTVAGLEKELSNAKE 760
T L K+ ++ + D+ K+ + +S L ++D +A + LS +K
Sbjct: 1193 AAT----LRKKQADSVAELGEQIDNLQ-RVKQKLEKEKSELKMEIDDMASNIEALSKSKS 1247
Query: 761 ELELMAKKERESQMELSALQSMMAVQEEELQVQAADMES----LTRNIQIKEDLIKDLQM 816
+E + + E+ A +L +Q A +++ L+ ++ KE LI L
Sbjct: 1248 NIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLT- 1306
Query: 817 QLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEA 876
+ A+ + +E+ E+ ++ + R L+ E +E+ E
Sbjct: 1307 -----KSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAEL 1361
Query: 877 LQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAA 936
+A + S + ++ E+ RT ++E E + L RL+E
Sbjct: 1362 QRALSKANSEVAQWRTKYETDAIQRTEELE-EAKKKLAQRLQEA---------------- 1404
Query: 937 IGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGG 996
++ +T+ S+E+ +Q ++ +E + +E + + +
Sbjct: 1405 -------EENTETANSKCASLEKT------KQRLQGEVEDLMRDLERSHTACATLDKKQR 1451
Query: 997 DSNRCLQEEMLHL---RAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLC 1053
+ ++ L E L +AE +E R EL +++ EE + +R +L
Sbjct: 1452 NFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEV-VDQLETLRRENKNLQ 1510
Query: 1054 LENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAH 1113
E ++L EQ+ E + E E+ K+ +V +E +S LQ +++G L+ H
Sbjct: 1511 EEISDLTEQIAETGKNLQEAEKTKK--------LVEQE---KSDLQVALEEVEGSLE--H 1557
Query: 1114 NIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPF 1173
+L+ QL LS + ++ IE++ + Q + + R
Sbjct: 1558 EESKILRVQLELSQVKSE---LDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRND 1614
Query: 1174 PRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEK 1233
+ QL + ++ + ++ G + + L + +DL+E+
Sbjct: 1615 ALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQ 1674
Query: 1234 LLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQD---LGYETCGRSENEAERE 1290
L + E ELE+ +V L ++ S+Q +D D L + N ++
Sbjct: 1675 LAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKL 1734
Query: 1291 ETTSPEC--EEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKS 1348
E +C E NS++E E E+ ++ T A+ + +L K+++ + +
Sbjct: 1735 EADIAQCQAEVENSIQESRNAE----EKAKKAITDAAM-----MAEELKKEQDTSAHLER 1785
Query: 1349 ENILVLRKDIKDLKAQLQNA--------NKVIQNLKSRVRSL 1382
L + +KDL+ +L A K IQ L++RVR L
Sbjct: 1786 MK-KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVREL 1826
Score = 76.3 bits (186), Expect = 3e-13
Identities = 97/461 (21%), Positives = 195/461 (42%), Gaps = 59/461 (12%)
Query: 1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQ------QKYEASREDIYKRNIELKVE 54
M N Y + L L++EN +L+ I L E++ Q+ E +++ + + +L+V
Sbjct: 1488 MRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVA 1547
Query: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQ- 113
+E ++ L+ ++ + + ++ SQ ++EL R+ E+ +E E + + + LQ
Sbjct: 1548 LEEVEGSLEHEESKILRVQLEL----SQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQS 1603
Query: 114 --EESRLAKNEAARMAALVEA---EKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEAL 168
+ ++N+A R+ +E E E L S + T+ Q+K Q
Sbjct: 1604 VLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQL---- 1659
Query: 169 AQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHE 228
L+ +L + E L EQL+ +++ LLEE M+V + E
Sbjct: 1660 --------HLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKV--------------ALE 1697
Query: 229 TTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE 288
T + +S+ L + +++Q + N L ++ ++ Q + +N +E
Sbjct: 1698 QTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEE 1757
Query: 289 TLKSRERETEELYQVIEGQNDTMAKLREM---LHQSQLGQLHSSEGTSPAQQQVALLDLQ 345
K + + + ++ + DT A L M L Q+ H + Q
Sbjct: 1758 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE-----------Q 1806
Query: 346 SALFCSQLEIQKLQRVVRQKERQL-ADAKQCVQFVEAAAHESEQQKEASWKHNQELRK-- 402
AL + +IQKL+ VR+ E +L + K+ + ++ A + KE +++ ++ +
Sbjct: 1807 LALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNIL 1866
Query: 403 ALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSL 443
LQ L ++LQ K + + E + TQ + + H L
Sbjct: 1867 RLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHEL 1907
Score = 66.2 bits (160), Expect = 4e-10
Identities = 187/1018 (18%), Positives = 400/1018 (39%), Gaps = 163/1018 (16%)
Query: 749 AGLEKELSNAKEELE-----LMAKKERESQMELSALQSMMAVQEEELQVQA--------- 794
A EKE++ KE+ E L + R ++E + + + +LQVQ+
Sbjct: 847 AEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAE 906
Query: 795 --------------ADMESLTRNIQIKEDLIKDLQMQLVDPED-IPAMERLTQEVLLLRE 839
A ++ LT ++ +E++ +L + + ED +++R ++ L
Sbjct: 907 ERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLT 966
Query: 840 KVASVESQGQEISGNRRQQLLLMLEG---LVDERSRLNEA-------LQAERQLYSSLVK 889
KV + + N +++ + E L E+ L EA LQ E + L+K
Sbjct: 967 KVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIK 1026
Query: 890 FHAHPE--------SSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLET-------- 933
+A E S E+++ L+ +LE A + +LE L S E + LE
Sbjct: 1027 INAKLEQQTDDLEGSLEQEKKLRADLERA---KRKLEGDLKMSQESIMDLENDKQQIEEK 1083
Query: 934 -------LAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNP 986
L+ + A DD + S +F I+E ++ +E+ +E ++
Sbjct: 1084 LKKKEFELSQL--QAKIDDEQVHSLQFQKKIKE----------LQARIEELEEEIEAEHT 1131
Query: 987 SFSPPSPMGGDSNRCLQEEMLHLR---AEFHQHLEEKRKAEEELKELKAQIEEAGFSSVS 1043
+ D R L+E L +E +K E E ++++ +EEA ++
Sbjct: 1132 LRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEA---TLQ 1188
Query: 1044 HIRNTMLSLCLENAELKEQMGEAMSDGWEIEE--DKEKGEVMVETVVTKEGLSESSLQAE 1101
H T +L + A+ ++GE + + +++ +KEK E+ +E + +
Sbjct: 1189 H-EATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEI---------DDMASN 1238
Query: 1102 FRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQ 1161
L N +++Q S + + +L+ L R+ T+ H+
Sbjct: 1239 IEALSKSKSNIERTCRTVEDQF--SEIKAKDEQQTQLIHDLNMQKARLQTQ--NGELSHR 1294
Query: 1162 HQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLS 1221
+E+ ++ + Q+L QL+ + + ++ ++ + Q R
Sbjct: 1295 VEEKESLISQLTKSKQAL---------TQQLEELKRQMEEETKAKNAMAHALQSSRHDCD 1345
Query: 1222 QCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCG 1281
+++Y++ QE + + +E+ ++R +++ + + +L++ +
Sbjct: 1346 LLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTE------ELEEAKKKLAQ 1399
Query: 1282 RSENEAEREETTSPECEEHNSLKEMVL--MEGLCSEQGRRGSTLASSSER-----KPLEN 1334
R + E ET + +C K+ + +E L + R + A+ ++ K L
Sbjct: 1400 RLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAE 1459
Query: 1335 QLGKQEEFRVY---------GKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVT 1385
K +E + S + +R +++ QL+ + +NL+ + L+
Sbjct: 1460 WKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQ 1519
Query: 1386 -SDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGL---QAKKDLE-S 1440
++ +L+ K + + E S +E EG L L Q K +L+
Sbjct: 1520 IAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRK 1579
Query: 1441 LIQRVSQLEAQLPKNG------LEEKLAEELRSAS----WPGKYDSLIQDQARELSYLRQ 1490
+I++ ++E QL +N L+ L E+RS + K + + + +L + +
Sbjct: 1580 VIEKDEEIE-QLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNR 1638
Query: 1491 KIREGRGICYLITRHAKDTVKSFEDLLRSN-DIDYYLGQSFR---------EQLAQGSQL 1540
++ E + + KD+ +D LRSN D+ L R E++ +
Sbjct: 1639 QMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQ 1698
Query: 1541 TERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKV-IEVLQAKLDARSLTPSSSHA 1599
TER T +LS ++ D+ L L + + + K+K+ ++ Q + + + S +A
Sbjct: 1699 TER-TRRLSEQELLDASDRVQL--LHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNA 1755
Query: 1600 LSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSK 1657
+ ++ + + +++EL+ D S + +K + D H + L+ K
Sbjct: 1756 EEKAKKAITDAAMMAEELKKEQD---TSAHLERMKKNLEQTVKDLQHRLDEAEQLALK 1810
Score = 51.6 bits (122), Expect = 9e-06
Identities = 68/295 (23%), Positives = 129/295 (43%), Gaps = 54/295 (18%)
Query: 1847 HLGEIRNLRQRLEESICINDR----LREQLEHR---LTSTARGRGSTSNFYSQGLESIPQ 1899
HL + + L+E + I +R L E+LE L T R R + + +
Sbjct: 1660 HLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQL 1719
Query: 1900 LCNENRVLREDNRRL-------QAQLSHVSREHSQETESLREALLSSRSHLQELEKE--- 1949
L ++N L ++L QA++ + +E E ++A+ + +EL+KE
Sbjct: 1720 LHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDT 1779
Query: 1950 ---LEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLF 2006
LE K +Q ++DL+ + E E+L+L+ ++Q ++ +
Sbjct: 1780 SAHLERMKKNLEQTVKDLQHRLDEA-----EQLALKGG-----------KKQIQKLENRV 1823
Query: 2007 ESLQSELQI-----YEALYGNSKKGLK----AYSLDACHQ--IPLSSDLSHLVAEVRALR 2055
L++EL + EAL G K K Y + H+ + L + L A+V++ +
Sbjct: 1824 RELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYK 1883
Query: 2056 GQLEQ-----SIQGNNCLRLQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQL 2105
Q E+ + Q + C R +Q +LE A +A ++ S +N+ S D G++++
Sbjct: 1884 RQAEEAEEQANTQLSRCRR--VQHELEEAAERADIAESQVNKLRAKSRDVGSQKM 1936
Score = 41.2 bits (95), Expect = 0.012
Identities = 33/172 (19%), Positives = 83/172 (48%), Gaps = 8/172 (4%)
Query: 1845 EEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNEN 1904
E+ + ++ +R +E + ++ R++LE ++ S + + E++
Sbjct: 850 EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERC 909
Query: 1905 RVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQE----LEKELEHQKVERQQL 1960
L + L+A++ ++ E +E E + L++ + +L++ L+++++ ++ ++
Sbjct: 910 EGLIKSKILLEAKVKELT-ERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKV 968
Query: 1961 LEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSE 2012
++ + +V + EE +L+EN S+L + LQ E QQ + LQ E
Sbjct: 969 EKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQ---EAHQQTLDDLQVE 1017
Score = 38.9 bits (89), Expect = 0.060
Identities = 50/209 (23%), Positives = 97/209 (46%), Gaps = 32/209 (15%)
Query: 1845 EEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFY---SQGL----ESI 1897
EE E+ ++ LE+ R + LE LT + + +T N S+ + E+I
Sbjct: 934 EEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENI 993
Query: 1898 PQLCNENRVLREDNRR----LQAQ------LSHVSREHSQETESLREALLSS---RSHLQ 1944
+L E + L+E +++ LQ + L ++ + Q+T+ L +L R+ L+
Sbjct: 994 SKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLE 1053
Query: 1945 ELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQEND-SRLQHKL-------VLLQ 1996
+++LE Q+ + DL +Q++ EE+L +E + S+LQ K+ + Q
Sbjct: 1054 RAKRKLEGDLKMSQESIMDLENDKQQI----EEKLKKKEFELSQLQAKIDDEQVHSLQFQ 1109
Query: 1997 QQCEEKQQLFESLQSELQIYEALYGNSKK 2025
++ +E Q E L+ E++ L +K
Sbjct: 1110 KKIKELQARIEELEEEIEAEHTLRAKIEK 1138
Score = 37.7 bits (86), Expect = 0.13
Identities = 44/245 (17%), Positives = 98/245 (40%), Gaps = 11/245 (4%)
Query: 1845 EEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNEN 1904
+E + ++ N +Q++EE + + QL+ ++ + I +L E
Sbjct: 1067 QESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEI 1126
Query: 1905 RVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHL----------QELEKELEHQK 1954
+++ Q S ++RE + +E L EA ++ + + Q++ ++LE
Sbjct: 1127 EAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEAT 1186
Query: 1955 VERQQLLEDLREKQQE-VLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSEL 2013
++ + LR+KQ + V E+ +LQ +L+ + L+ + ++ E+L
Sbjct: 1187 LQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSK 1246
Query: 2014 QIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQ 2073
E + Q L DL+ A ++ G+L ++ L QL
Sbjct: 1247 SNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLT 1306
Query: 2074 QQLES 2078
+ ++
Sbjct: 1307 KSKQA 1311
Score = 37.7 bits (86), Expect = 0.13
Identities = 43/233 (18%), Positives = 99/233 (42%), Gaps = 17/233 (7%)
Query: 1845 EEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNEN 1904
++ + E++ + LEE I LR ++E + + AR S + + N
Sbjct: 1109 QKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMN 1168
Query: 1905 RVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDL 1964
+ + ++++ L + +H +LR+ S + EL +++++ + +Q+L ++
Sbjct: 1169 KKREAEFQKMRRDLEEATLQHEATAATLRKKQADS---VAELGEQIDNLQRVKQKLEKEK 1225
Query: 1965 REKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSK 2024
E + E+ +L ++ S ++ ++ Q E + E Q++L
Sbjct: 1226 SELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQ-QTQL----------- 1273
Query: 2025 KGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLE 2077
+ ++ + +LSH V E +L QL +S Q +L++Q+E
Sbjct: 1274 --IHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQME 1324
Score = 33.1 bits (74), Expect = 3.3
Identities = 41/167 (24%), Positives = 68/167 (40%), Gaps = 12/167 (7%)
Query: 1856 QRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQ-LCNENRVLREDNRRL 1914
QR EE +L ++L+ +T T+N LE Q L E L D R
Sbjct: 1385 QRTEELEEAKKKLAQRLQEAEENT-----ETANSKCASLEKTKQRLQGEVEDLMRDLERS 1439
Query: 1915 Q---AQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEV 1971
A L R + ++ L S++ L+ +KE E ++ E ++
Sbjct: 1440 HTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQL 1499
Query: 1972 LHFREERLSLQENDSRLQHKLVLL---QQQCEEKQQLFESLQSELQI 2015
R E +LQE S L ++ Q+ E+ ++L E +S+LQ+
Sbjct: 1500 ETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQV 1546
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 136 bits (342), Expect = 3e-31
Identities = 301/1388 (21%), Positives = 563/1388 (40%), Gaps = 150/1388 (10%)
Query: 6 RTLSQHLND---LKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKREL 62
+ LS L D L+++N L+ ++ LEE + Q + ++ + ++ +++E+LK+E
Sbjct: 364 KELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDV-LQLETLKQEA 422
Query: 63 QDKKQHLDKTWADVENLNS---QNEAEL---RRQFEERQQETEHVYELLENKIQ-LLQEE 115
+ + A VE L + Q EA+L R FEE +Q+ + L++ I L Q +
Sbjct: 423 ATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAK 482
Query: 116 SRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRI 175
L + A A L EL+ + + +++ G + + + LAQ ++
Sbjct: 483 EELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQ 542
Query: 176 EELNQSLAAQ-ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQ 234
E+ +Q L Q E+L L +++QQL + E+ +E +Q T ++
Sbjct: 543 EQASQGLRHQVEQLSSSLKQKEQQLKEVAEK----------QEATRQDHAQQLATAAEER 592
Query: 235 SVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRE 294
S L E ++Q EA K KL + +L+ A E+ ++ +
Sbjct: 593 EAS---LRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELS 649
Query: 295 RETEELYQVIEG----QNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFC 350
R+ EEL +E Q++ A++ E+ Q + Q ++E AQ++ L + AL
Sbjct: 650 RKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKE 709
Query: 351 SQLEIQK--LQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQE-------LR 401
S L++ K L+ R+ L + ++C+ ++A +Q + K +E L
Sbjct: 710 S-LKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLE 768
Query: 402 KALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSH-KEQLLQEFRELLQYR 460
LQQL E Q +++ LR AE T E + L ++ +E+ +E QY
Sbjct: 769 ARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYG 828
Query: 461 DNSDKTLEANEMLLEKLRQRIHD---KAVALERAIDEKFS---------------ALEE- 501
+ L + EK RQ + + K +E + + S AL++
Sbjct: 829 AMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQV 888
Query: 502 KEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNL--- 558
+EKE+R +LA DL L++ +++ + +E+L+R G EQ T + L
Sbjct: 889 QEKEVRAQKLA-----DDLSTLQEKMAATSKEVARLETLVRKAG---EQQETASRELVKE 940
Query: 559 ---------QWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQ 609
+WL+E+ +F Q + +Q ++ E+E L A L+ G Q
Sbjct: 941 PARAGDRQPEWLEEQQGRQFCSTQ----AALQAMEREAEQMGNELERLRAALMESQGQQQ 996
Query: 610 SEIAE---ELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKL 666
E + E+ + Q + R DL ++ + E EM +Q L + E E L
Sbjct: 997 EERGQQEREVARLTQERGRAQADLALEKAARA-ELEMRLQNALNE---QRVEFATLQEAL 1052
Query: 667 VQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDS 726
AL E+ + Q L + G + + + Q + K+ + S ++ ++
Sbjct: 1053 AHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGS-GAQSEA 1111
Query: 727 TSLTAKEDVSIP--RSTLGDLDTVAGLEKELSNAKE---ELELMAKKERESQMELSALQS 781
T + R+ + L+ ++E +++ E E E ++ ER+S +E LQ
Sbjct: 1112 AGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALE--TLQG 1169
Query: 782 MMAVQEEELQVQAADMESLTRNIQIKEDLIKDL-----QMQLVDPEDIPAMERLTQEVLL 836
+ + +EL + + S R + ++D + + ER +
Sbjct: 1170 QLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISS 1229
Query: 837 LREKVASVESQGQEISGNRRQ-QLLLMLEG----LVDERSRLNEALQAERQLYSSLVKFH 891
L E+V+ + Q E G ++ + L+M E ++ER RL LQAE S+
Sbjct: 1230 LEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRL---LQAETASNSARA--- 1283
Query: 892 AHPESSERD--RTLQVELEGAQVLRSRLEEVLGRSLERLNRL--------ETLAAIGGAA 941
A S+ R+ ++L+ E E +V L + L ER L E A
Sbjct: 1284 AERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQAL 1343
Query: 942 AGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRC 1001
+ E TST+ S E A H QQL E++ A + GG
Sbjct: 1344 STLQLEHTSTQALVS-ELLPAKHLCQQL---QAEQAAAEKRHREELEQSKQAAGG----- 1394
Query: 1002 LQEEMLHLRAEFHQHLEEKRK-AEEELKELKAQIEEAGFSS-VSHIRNTMLSLCLENAEL 1059
L+ E+L + E + + ++K AE+E + + E+A ++ +S ++ L EN L
Sbjct: 1395 LRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGL 1454
Query: 1060 KEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLL 1119
E+ E+E D+ + E V+ + +E+ L R+ Q + ++
Sbjct: 1455 GERANLGRQF-LEVELDQAR-EKYVQELAAVRADAETRLAEVQREAQSTARELE-VMTAK 1511
Query: 1120 KEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSL 1179
E + E + E LT+ +E++ Q E V + +
Sbjct: 1512 YEGAKVKVLEERQRFQEERQ-KLTAQVEQLEV----------FQREQTKQVEELSKKLA- 1559
Query: 1180 DLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEA 1239
D V +L Q A L L++QLSQ +Q + + ++ ++
Sbjct: 1560 DSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKT 1619
Query: 1240 TVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEE 1299
A+ + ++ + L +++++K+++ + + LG+E E E+T +
Sbjct: 1620 HYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQ 1679
Query: 1300 HNSLKEMV 1307
SL+ V
Sbjct: 1680 VRSLEAQV 1687
Score = 126 bits (317), Expect = 2e-28
Identities = 324/1543 (20%), Positives = 599/1543 (38%), Gaps = 266/1543 (17%)
Query: 8 LSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQ 67
+ + +N L +EN L ++ +QQ +A E + + K E L+++ Q +K+
Sbjct: 309 MDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHS---KATQEWLEKQAQLEKE 365
Query: 68 HLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQ--------LLQEESRLA 119
L D + L +NE L+ + + + EH+ +L +N Q +LQ E+
Sbjct: 366 -LSAALQDKKCLEEKNEI-LQGKLSQLE---EHLSQLQDNPPQEKGEVLGDVLQLET--L 418
Query: 120 KNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQR---DKRIE 176
K EAA +AA + + +E+ E +G Q + LA+R ++ +
Sbjct: 419 KQEAATLAA-NNTQLQARVEMLETERG---------------QQEAKLLAERGHFEEEKQ 462
Query: 177 ELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLK-QQKLNSHETTITQQS 235
+L+ + + + LS+ K++ LE+ + +T ++ +L + TI QQ
Sbjct: 463 QLSSLITDLQSSISNLSQAKEE----LEQASQAHGARLTAQVASLTSELTTLNATIQQQD 518
Query: 236 VSDSHL--------AELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLK 287
+ L A+L + +QQ E ++ L+ ++ ++S LK QK+ Q LK
Sbjct: 519 QELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLK------QKE----QQLK 568
Query: 288 ETLKSRERETEE-LYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQ- 345
E + +E ++ Q+ + A LRE + L QL + E A+ ++ LQ
Sbjct: 569 EVAEKQEATRQDHAQQLATAAEEREASLRE--RDAALKQLEALEKEKAAKLEILQQQLQV 626
Query: 346 --SALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQ-KEASWKHNQELRK 402
A +Q + + QR + R++ + + CV+ HE++ Q E + E +K
Sbjct: 627 ANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQK 686
Query: 403 ALQ---------QLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 453
A + QLQE+LQ + L+ + E R ++ +S +L E
Sbjct: 687 ATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCIS---ELKAET 743
Query: 454 RELLQYRDNSDKTLEAN-------EMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKEL 506
R L++ K LE E L++L + + L R + E +A E E
Sbjct: 744 RSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESEC 803
Query: 507 RQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEME 566
QL +++V + E S + + + EQL T LKEE E
Sbjct: 804 EQL-------------VKEVAAWRERYEDSQQEEAQYGAMFQEQLMT-------LKEECE 843
Query: 567 TKFSRWQKEQESII---QQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRK 623
Q+ +E + + + + E+ +L A L L Q++Q K
Sbjct: 844 KARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARAL------------QQVQEK 891
Query: 624 E---RMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQAL 680
E + L D LS +++ E+ L V ++ + A+ +LV+
Sbjct: 892 EVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEW 951
Query: 681 RQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRS 740
+ GR +QA + + E G ++ M+ + + +
Sbjct: 952 LEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQERE------ 1005
Query: 741 TLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESL 800
VA L +E A+ +L L E +M L + V+ LQ E+L
Sbjct: 1006 -------VARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQ------EAL 1052
Query: 801 TRNIQIKEDLIKDL-QMQLVDPEDIPAMERLTQEVLLLREKVASVE------SQGQEISG 853
+ KE ++L +++ ++ I +E L Q V L+E++A E S Q +
Sbjct: 1053 AHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAA 1112
Query: 854 NRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGA-QV 912
R + LE L E S+L + Q +++ SL + S E +R + E + A +
Sbjct: 1113 GRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLER------SLEAERASRAERDSALET 1166
Query: 913 LRSRLEE---VLGRSLERL-NRLETLAAI---------------GGAAAGDDTEDTSTEF 953
L+ +LEE LG S L + LAA A G +
Sbjct: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSL 1226
Query: 954 TDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEF 1013
S+EEE + + Q L K K L + + ++ L+E + L+AE
Sbjct: 1227 ISSLEEEVSILNRQVLEKEGESKELKRLVMAE----------SEKSQKLEERLRLLQAET 1276
Query: 1014 HQH----LEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSD 1069
+ E EE++ L+ + E+ +S ++R + S AE E++G+ +
Sbjct: 1277 ASNSARAAERSSALREEVQSLREEAEKQRVAS-ENLRQELTS----QAERAEELGQELK- 1330
Query: 1070 GWE---IEEDKEKGEVMVETVVTKEGLSE--------SSLQAE----FRKLQGKLKNAHN 1114
W+ ++++ + +E T+ +SE LQAE ++ + +L+ +
Sbjct: 1331 AWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQ 1390
Query: 1115 IINLLKEQLVLSSKE-GNSKLTPELLVHLTSTIERINTELVG-----SPGKHQH----QE 1164
L+ +L+ + +E G + + T +++ E S K H +E
Sbjct: 1391 AAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE 1450
Query: 1165 EGNVTVRPFPRPQSLDLG------------ATFTVDAH------QLDNQSQPRDPGPQSA 1206
+ R Q L++ A DA Q + QS R+ +A
Sbjct: 1451 NRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTA 1510
Query: 1207 FSLPGSTQHLRSQLSQCKQRYQDLQEKLL--LSEATVF--AQANELEKYRVMLTGESLVK 1262
+ + ++ + +QR+Q+ ++KL + + VF Q ++E+ L
Sbjct: 1511 -----KYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQAS 1565
Query: 1263 QDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGST 1322
+ +Q +Q G G S+ EA+R + E + S KE + +
Sbjct: 1566 KVQQQKLKAVQAQG----GESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHY 1621
Query: 1323 LASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQ-------NANKVIQNL 1375
A + + L+ QL E+ + K LR + + L +LQ A + ++L
Sbjct: 1622 DAKKQQNQELQEQLRSLEQLQKENKE-----LRAEAERLGHELQQAGLKTKEAEQTCRHL 1676
Query: 1376 KSRVRSLSVTSDYSSSLERPWKLRAVGT--LEGSSPHSVPDED 1416
++VRSL ++ R V T L+ P + P D
Sbjct: 1677 TAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLD 1719
Score = 121 bits (304), Expect = 7e-27
Identities = 351/1738 (20%), Positives = 663/1738 (38%), Gaps = 271/1738 (15%)
Query: 87 LRRQF-EERQQETEHVYELLENKIQLLQEESRLA--KNEAARMAALVEAEKECNLELSEK 143
L++Q +ER E EL EN+ L ++++++A + R+A L E + LE E
Sbjct: 219 LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKEL 278
Query: 144 LKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLL 203
+ KN + T L + K+ ++L + +R + QLS E L L
Sbjct: 279 EELRDKN-----------ESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKL 327
Query: 204 EEPTS--MEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEK 261
E S ++Q EL ++ + E Q + A LQ+K + E N+ILQ K
Sbjct: 328 REFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDK-KCLEEKNEILQGK 386
Query: 262 LNEMSYELKCAQESSQKQDGTIQN---LKETLKSR------------------------- 293
L+++ L Q++ ++ G + ETLK
Sbjct: 387 LSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQ 446
Query: 294 -----------ERETEELYQVIEGQNDTMAKLREMLHQ-SQLGQLHSSEGTSPAQQQVAL 341
E E ++L +I +++ L + + Q Q H + T+ +
Sbjct: 447 EAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSE 506
Query: 342 LDLQSALFCSQ-LEIQKLQRVVRQKERQLADA-KQCVQFVEAAAHESEQQKEASWKHNQE 399
L +A Q E+ L++ ++K+ QLA +Q Q + H+ EQ + + Q+
Sbjct: 507 LTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQ 566
Query: 400 LRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQY 459
L++ ++ + Q+ +QQL E+ +R ++ ++ L K L+ ++ LQ
Sbjct: 567 LKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQV 626
Query: 460 RDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHD 519
+ + + + + ++ + + K L+ ++ E + ++ +L L +R
Sbjct: 627 ANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQK 686
Query: 520 LERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESI 579
V + + +++L + + L + EE + S + E S+
Sbjct: 687 ATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSL 746
Query: 580 IQQLQTSLHDR-NKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQV 638
++Q H R KE+E+ A G ++L + Q + +L+ L++
Sbjct: 747 VEQ-----HKRERKELEEERAG-----RKGLEARLQQLGEAHQAETEVLRRELAEAMAAQ 796
Query: 639 LEHEMEIQGLLQSVS--------TREQESQAAA--EKLVQALMER----NSELQALRQYL 684
E E + L++ V+ ++++E+Q A ++ + L E ELQ ++ +
Sbjct: 797 HTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKV 856
Query: 685 GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGD 744
G +S S+ IS QQ E+ L + Q+ ++ A + ++
Sbjct: 857 AGIES-HSELQISRQQNELAE---LHANLARALQQVQEKEVRAQKLADDLSTLQEKMAAT 912
Query: 745 LDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQ---VQAADMESLT 801
VA LE + A E+ E +++ + Q +++ Q QAA ++++
Sbjct: 913 SKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAA-LQAME 971
Query: 802 RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL 861
R + + ++ L+ L++ + ER QE +VA + + G + L L
Sbjct: 972 REAEQMGNELERLRAALMESQGQQQEERGQQE-----REVARLTQE----RGRAQADLAL 1022
Query: 862 MLEGLVDERSRLNEALQAERQLYSSLVKFHAH----PESSERDRTLQVELEGAQVLR-SR 916
+ RL AL +R +++L + AH E +++ LE AQ+
Sbjct: 1023 EKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEE 1082
Query: 917 LEEVLGRSLERLNRLETLAAIGGAA---AGDDTEDTSTEFTDSIEEEAA----HHSHQQL 969
L + + + E+L + E A G A A TE T + +++ E + QQ
Sbjct: 1083 LRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKL-EALRAEVSKLEQQCQKQQE 1141
Query: 970 VKVALEKSL-----------ATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLE 1018
+LE+SL + +ET + G S L L A F ++
Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQREL-AAFRTKVQ 1200
Query: 1019 EKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKE 1078
+ KAE+E K A+ + S I + + + N ++ E+ GE+ + + E
Sbjct: 1201 DHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESE 1260
Query: 1079 KGEVMVE--TVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTP 1136
K + + E ++ E S S+ AE + + L+E+ E +
Sbjct: 1261 KSQKLEERLRLLQAETASNSARAAE------RSSALREEVQSLREE-----AEKQRVASE 1309
Query: 1137 ELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQS 1196
L LTS ER E +G K + + F + Q+L QL++
Sbjct: 1310 NLRQELTSQAER--AEELGQELKAWQE-------KFFQKEQAL--------STLQLEHT- 1351
Query: 1197 QPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLT 1256
STQ L S+L K Q LQ + +E + + ++ L
Sbjct: 1352 ---------------STQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLR 1396
Query: 1257 GESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLM----EGL 1312
E L Q ++LG E + AE+E T E S E + M GL
Sbjct: 1397 AELLRAQ---------RELG-ELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGL 1446
Query: 1313 CSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVI 1372
+E+ RG ++ R+ LE +L + E V + + +R D + A++Q
Sbjct: 1447 LAEE-NRGLGERANLGRQFLEVELDQAREKYV----QELAAVRADAETRLAEVQ------ 1495
Query: 1373 QNLKSRVRSLSV-TSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPG 1431
+ +S R L V T+ Y EG+ + +
Sbjct: 1496 REAQSTARELEVMTAKY----------------EGAKVKVLEERQ--------------- 1524
Query: 1432 LQAKKDLESLIQRVSQLEA-QLPKNGLEEKLAEELRSASWPGKYDSLIQDQARELSYLRQ 1490
+ +++ + L +V QLE Q + E+L+++L + DQA ++ +
Sbjct: 1525 -RFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADS-----------DQASKVQQQKL 1572
Query: 1491 KIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLST 1550
K + +G ++ + + L N++ L Q +EQ A+ +L ++ +
Sbjct: 1573 KAVQAQG------GESQQEAQRLQAQL--NELQAQLSQ--KEQAAEHYKL--QMEKAKTH 1620
Query: 1551 KDHKSEKDQAGLEPLALRLSRELQEKEKVI---------EVLQAKLDARSLTPSSSHALS 1601
D K +++Q E LR +LQ++ K + E+ QA L + + H +
Sbjct: 1621 YDAKKQQNQELQE--QLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTA 1678
Query: 1602 DSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSST 1661
+ + +L + ++ E +A P SI S + S T
Sbjct: 1679 QVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSIT 1738
Query: 1662 SASQGAKAESNSNP--ISLPTPQNTPKEANQAHSGFHFHSIPKLASLPQAPLPSAPSS 1717
S + + S P + P Q P + S +F IP + QAPL S+ S
Sbjct: 1739 SKLPRTQPDGTSVPGEPASPISQRLPPKVESLES-LYFTPIP---ARSQAPLESSLDS 1792
Score = 76.6 bits (187), Expect = 3e-13
Identities = 137/692 (19%), Positives = 281/692 (40%), Gaps = 86/692 (12%)
Query: 21 SLKLRIYFLEERMQQKYEASREDIYKRNIELK--------VEVESLKRELQDKKQHLDKT 72
+L+ + LE++ Q++ E + D +R++E + +E+L+ +L++K Q L +
Sbjct: 1124 ALRAEVSKLEQQCQKQQEQA--DSLERSLEAERASRAERDSALETLQGQLEEKAQELGHS 1181
Query: 73 WADVENL-------------NSQNEAELRRQFEERQQETEHVYEL---LENKIQLLQEES 116
+ + + +S+ E E + Q +QE E L LE ++ +L +
Sbjct: 1182 QSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQV 1241
Query: 117 RLAKNEAARMAALVEAEKECNLELSEKLK----------------------GVTKNWEDV 154
+ E+ + LV AE E + +L E+L+ V E+
Sbjct: 1242 LEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEA 1301
Query: 155 PGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPM 214
+V + + L + +R EEL Q L A + E+ +++Q L L E TS Q +
Sbjct: 1302 EKQRVASENLRQELTSQAERAEELGQELKAWQ---EKFFQKEQALSTLQLEHTS--TQAL 1356
Query: 215 TEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQE 274
ELL + L + Q + H EL++ Q L E+ EL ++
Sbjct: 1357 VSELLPAKHL-CQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELG-ELIPLRQ 1414
Query: 275 SSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSP 334
+Q+ T Q L+ S E+L + + + R + ++ LG+
Sbjct: 1415 KVAEQERTAQQLRAEKASY---AEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQ 1471
Query: 335 AQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASW 394
A+++ + +L + ++ + ++QR + R+L + E A + ++++
Sbjct: 1472 AREKY-VQELAAVRADAETRLAEVQREAQSTAREL---EVMTAKYEGAKVKVLEERQRFQ 1527
Query: 395 KHNQELRKALQQL---QEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLN----HSLSHKE 447
+ Q+L ++QL Q E + ++L A+ + Q+Q ++ + S +
Sbjct: 1528 EERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQ 1587
Query: 448 QLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR 507
+L + EL ++ E ++ +EK + +D + + E+ +LE+ +KE +
Sbjct: 1588 RLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTH-YDAKKQQNQELQEQLRSLEQLQKENK 1646
Query: 508 QLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 567
+LR H+L++ E T + + + +R+ +V ++L + +
Sbjct: 1647 ELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDA 1706
Query: 568 KFSRWQKEQESIIQQLQTSLHDRNKEVED-LSATLLCKLGPGQ-------SEIAEELCQR 619
SR + QL S+ + E+ ++ KL Q E A + QR
Sbjct: 1707 LKSR----EPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPISQR 1762
Query: 620 LQRKERMLQDL----LSDRNKQVLEHEMEIQG 647
L K L+ L + R++ LE ++ G
Sbjct: 1763 LPPKVESLESLYFTPIPARSQAPLESSLDSLG 1794
Score = 74.7 bits (182), Expect = 1e-12
Identities = 277/1573 (17%), Positives = 572/1573 (36%), Gaps = 232/1573 (14%)
Query: 525 DVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQK--EQESIIQQ 582
D+L + + M+ ++ L + ++L + L E + + + Q+ ++ +++ +
Sbjct: 207 DILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNE 266
Query: 583 LQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNK------ 636
Q + KE+E+L + E L RL + QDL +++++
Sbjct: 267 KQAASPLEPKELEELR------------DKNESLTMRLHETLKQCQDLKTEKSQMDRKIN 314
Query: 637 QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPI 696
Q+ E ++ L+ ++ Q+ Q A +L + +A +++L + L +
Sbjct: 315 QLSEENGDLSFKLREFASHLQQLQDALNELTE------EHSKATQEWLEKQAQLEKELSA 368
Query: 697 SNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELS 756
+ Q + CL ++ + ++ ++ S LGD+ +L
Sbjct: 369 ALQDKK-----CLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDV-------LQLE 416
Query: 757 NAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQM 816
K+E +A + Q + L++ QE +L + E + + LI DLQ
Sbjct: 417 TLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLS---SLITDLQS 473
Query: 817 QLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEA 876
+ ++ + + ++ S +L + L E + LN
Sbjct: 474 SI--------------------SNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNAT 513
Query: 877 LQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAA 936
+Q + Q + L K A + ++ +TLQ + + +Q LR ++E++ ++ +L+ +A
Sbjct: 514 IQQQDQELAGL-KQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAE 572
Query: 937 IGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGG 996
++EA H Q + A E+ A++ ++ + +
Sbjct: 573 ---------------------KQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEK 611
Query: 997 DSNRCLQ--EEMLHLRAEFHQHLEEK-RKAEEELKELKAQIEEAGFSSVSHIRNTMLSLC 1053
+ L+ ++ L + E + +A+ E EL ++EE L C
Sbjct: 612 EKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEE-------------LQAC 658
Query: 1054 LENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAH 1113
+E A ++ +A E++ E+ + + V +E + LQ + + L+ LK
Sbjct: 659 VETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQE---KDQLQEQLQALKESLKVTK 715
Query: 1114 NIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPF 1173
+ K + + E + EL S +E QH+ E
Sbjct: 716 GSLEEEKRRAA-DALEEQQRCISELKAETRSLVE-------------QHKRERKELEEER 761
Query: 1174 PRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSA--FSLPGSTQHLRSQLSQCKQRYQD-- 1229
+ L+ +AHQ + + R+ A + + L +++ ++RY+D
Sbjct: 762 AGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQ 821
Query: 1230 ---------LQEKLLLSEATVFAQANELEKYRVMLTG-ESLVKQDSKQIQVDLQDLGYET 1279
QE+L+ + EL++ + + G ES + + Q +L +L
Sbjct: 822 QEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANL 881
Query: 1280 CGRSENEAEREETTSPECEEHNSL--------KEMVLMEGLCSEQGRRGSTLASSSERKP 1331
+ E+E ++ ++L KE+ +E L + G + T + ++P
Sbjct: 882 ARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEP 941
Query: 1332 LENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSS 1391
+Q E+ + + ++ ++ + + ++ R+R+ + S
Sbjct: 942 ARAG-DRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELE----RLRAALMESQGQQQ 996
Query: 1392 LERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQ 1451
ER + R V L + D + A+ +LE +Q E +
Sbjct: 997 EERGQQEREVARLTQERGRAQAD-------------LALEKAARAELEMRLQNALN-EQR 1042
Query: 1452 LPKNGLEEKLAEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVK 1511
+ L+E LA L GK L + + E + +++ + TVK
Sbjct: 1043 VEFATLQEALAHALTEKE--GKDQELAKLRGLEAAQIKE------------LEELRQTVK 1088
Query: 1512 SFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSR 1571
++ L + ++ G + + A ++ T L + K E+ + A L R
Sbjct: 1089 QLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLER 1148
Query: 1572 ELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTH 1631
L+ + +A+ D+ T S ++ S + E + V +++
Sbjct: 1149 SLEAER----ASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSK 1204
Query: 1632 YEEKKASPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQA 1691
E++ + ++++SS S E L E +Q
Sbjct: 1205 AEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQ- 1263
Query: 1692 HSGFHFHSIPKLASLPQAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQK 1751
+ + L QA S + S V SL E ++ ++ +
Sbjct: 1264 -------KLEERLRLLQAETASNSARAAERS-------SALREEVQSLREEAEKQRVASE 1309
Query: 1752 QLGESASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGS--SG 1809
L + ++ A A L +L+A + Q S T++L +
Sbjct: 1310 NLRQELTS--QAERAEELGQELKAWQEKFFQKEQALS----TLQLEHTSTQALVSELLPA 1363
Query: 1810 KWDVMRPQKGSVSGDLSSGSSVYQLNSKPTG--ADLL--EEHLGEIRNLRQRLEESICIN 1865
K + Q + + + Q G A+LL + LGE+ LRQ++ E
Sbjct: 1364 KHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTA 1423
Query: 1866 DRLR-------EQLEHR------LTSTARGRGSTSNFYSQGLESIPQLCNENRV-----L 1907
+LR EQL L RG G +N Q LE E V +
Sbjct: 1424 QQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAV 1483
Query: 1908 REDNRRLQAQLSHVSREHSQETESL-------REALLSSRSHLQELEKELEHQKVERQQL 1960
R D A++ ++ ++E E + + +L R QE ++L Q VE+ ++
Sbjct: 1484 RADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQ-VEQLEV 1542
Query: 1961 LEDLREKQQEVLHFREERLSLQENDSRLQH-KLVLLQQQCEEKQQLFESLQSELQIYEAL 2019
+ + KQ E L ++L+ + S++Q KL +Q Q E QQ + LQ++L +A
Sbjct: 1543 FQREQTKQVEEL---SKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599
Query: 2020 YGNSKKGLKAYSL 2032
++ + Y L
Sbjct: 1600 LSQKEQAAEHYKL 1612
Score = 63.5 bits (153), Expect = 2e-09
Identities = 149/677 (22%), Positives = 269/677 (39%), Gaps = 80/677 (11%)
Query: 1438 LESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLI----------QDQARELSY 1487
++ I R++ L + + LE K EELR K +SL QD E S
Sbjct: 254 MQQRIDRLALLNEKQAASPLEPKELEELRD-----KNESLTMRLHETLKQCQDLKTEKSQ 308
Query: 1488 LRQKIR---EGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERL 1544
+ +KI E G R ++ +D L N++ ++ +E L + +QL + L
Sbjct: 309 MDRKINQLSEENGDLSFKLREFASHLQQLQDAL--NELTEEHSKATQEWLEKQAQLEKEL 366
Query: 1545 TSKLSTK---DHKSEKDQAGLEPLALRLSRELQEK--EKVIEVLQAKLDARSLTPSSSHA 1599
++ L K + K+E Q L L LS +LQ+ ++ EVL L +L ++
Sbjct: 367 SAALQDKKCLEEKNEILQGKLSQLEEHLS-QLQDNPPQEKGEVLGDVLQLETLKQEAATL 425
Query: 1600 LSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPS 1659
+++ + + L E + +++E H+EE+K S + SS S + +K
Sbjct: 426 AANNTQLQARVEMLETE-RGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEE 484
Query: 1660 STSASQ--GAK--AESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKLASLPQAPLPSAP 1715
ASQ GA+ A+ S L T T ++ +Q +G + K A L Q L
Sbjct: 485 LEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQT-LQQQE 543
Query: 1716 SSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGESASTVPPASTATLLSNDLEA 1775
+ L + L E ++ + ++ + +T A+L D
Sbjct: 544 QASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAAL 603
Query: 1776 DSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVS-----GDLSSGSS 1830
L + + + I ++ S + V + Q+ +L +
Sbjct: 604 KQ---LEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE 660
Query: 1831 VYQLNSKPTGADLLEEHLGEIRNLRQRLEESICI---NDRLREQLEHRLTSTARGRGSTS 1887
+ A + E L ++R+ +Q+ E + D+L+EQL+ S +GS
Sbjct: 661 TARQEQHEAQAQVAELEL-QLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLE 719
Query: 1888 NFYSQGLES-------IPQLCNENRVLREDNRR--------------LQAQLSHVSREHS 1926
+ ++ I +L E R L E ++R L+A+L + H
Sbjct: 720 EEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQ 779
Query: 1927 QETESLR----EALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQ 1982
ETE LR EA+ + + E E+ ++ R++ + +E+ Q F+E+ ++L+
Sbjct: 780 AETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLK 839
Query: 1983 ENDSRLQHKLVLLQQQCEEKQQLFESLQSELQI------YEALYGNSKKGLKAYSLDACH 2036
E + + +L Q+ +EK ES SELQI L+ N + L+
Sbjct: 840 EECEKARQEL----QEAKEKVAGIES-HSELQISRQQNELAELHANLARALQQVQEKEVR 894
Query: 2037 QIPLSSDLSHLVAEVRA 2053
L+ DLS L ++ A
Sbjct: 895 AQKLADDLSTLQEKMAA 911
Score = 59.3 bits (142), Expect = 4e-08
Identities = 282/1386 (20%), Positives = 524/1386 (37%), Gaps = 244/1386 (17%)
Query: 804 IQIKEDLIKDLQMQLVD-------PEDI-PAMERLTQEVLLLR-EKVASVESQGQEISGN 854
+ + EDL LQ V PE++ P + +E+ L +KVAS S +SG+
Sbjct: 141 LNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGS 200
Query: 855 RRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLR 914
+ +L+ + RL + L ER S RD L++EL + L
Sbjct: 201 PASPMGDILQTPQFQMRRLKKQLADER---------------SNRDE-LELELAENRKLL 244
Query: 915 SRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVAL 974
+ + + +R++RL A + A E E E H+ L +
Sbjct: 245 TEKDAQIAMMQQRIDRL---ALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQC-- 299
Query: 975 EKSLATVETQ-NPSFSPPSPMGGDSNRCLQEEMLHLRA---EFHQHLEEKRKAEEELKEL 1030
+ L T ++Q + + S GD + L+E HL+ ++ EE KA +E E
Sbjct: 300 -QDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEK 358
Query: 1031 KAQIEEAGFSSVS-----HIRNTMLSLCLENAELK---------EQMGEAMSDGWEIEED 1076
+AQ+E+ +++ +N +L L E ++ GE + D ++E
Sbjct: 359 QAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETL 418
Query: 1077 KEKGEVM----------VETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLL------- 1119
K++ + VE + T+ G E+ L AE + + + ++I L
Sbjct: 419 KQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNL 478
Query: 1120 ---KEQLVLSSKEGNSKLTPEL------LVHLTSTIERINTELVGSPGKHQHQEEGNVTV 1170
KE+L +S+ ++LT ++ L L +TI++ + EL G K Q +E+
Sbjct: 479 SQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGL--KQQAKEKQAQLA 536
Query: 1171 RPFPRPQSLDLGATFTVD--AHQLDNQSQP------------RDPGPQSAFSLPGSTQHL 1216
+ + + G V+ + L + Q +D Q A + L
Sbjct: 537 QTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASL 596
Query: 1217 RSQLSQCKQ----------RYQDLQEKL-LLSEATVFAQAN----ELEKYRVMLTGESL- 1260
R + + KQ + + LQ++L + +EA AQ + + EK + E L
Sbjct: 597 RERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQ 656
Query: 1261 -----VKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPEC---EEHNSLKEMV-LMEG 1311
+Q+ + Q + +L + + E+E + E+ +LKE + + +G
Sbjct: 657 ACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKG 716
Query: 1312 LCSEQGRRGSTLASSSER-----KPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQ 1366
E+ RR + +R K L +Q + R + E RK ++ QL
Sbjct: 717 SLEEEKRRAADALEEQQRCISELKAETRSLVEQHK-RERKELEEERAGRKGLEARLQQLG 775
Query: 1367 NANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGA 1426
A++ + R + ++ + +++ E ++ V S +E + GA
Sbjct: 776 EAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQ------YGA 829
Query: 1427 FYSPGL--------QAKKDLESLIQRV------SQLEAQLPKNGLEEKLAEELRSASWPG 1472
+ L +A+++L+ ++V S+L+ +N L E A R+
Sbjct: 830 MFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQ 889
Query: 1473 KYDSLIQDQARELSYLRQKI----REGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQ 1528
+ + Q A +LS L++K+ +E + L+ + + + +L++ G
Sbjct: 890 EKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKE---PARAGD 946
Query: 1529 SFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLD 1588
E L + Q + +++ + + + E +Q G E LR + + ++ E Q + +
Sbjct: 947 RQPEWLEE-QQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQERE 1005
Query: 1589 ARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHS 1648
LT A +D ++ + L L+ + V E+ +E A H+ +
Sbjct: 1006 VARLTQERGRAQADLALEKAARAELEMRLQNALNEQRV-EFATLQEALA---HALTEKEG 1061
Query: 1649 SHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAH-SGFHFHSIPKLASLP 1707
+ +K A+Q + E + Q KE A SG + +
Sbjct: 1062 KDQEL--AKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRT---- 1115
Query: 1708 QAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGESASTVPPASTAT 1767
PTGP L E +++ +Q+ Q Q+Q A
Sbjct: 1116 --------------EPTGPKL----EALRAEVSKLEQQCQKQQEQ-------------AD 1144
Query: 1768 LLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVSGDLSS 1827
L LEA+ + +G +E + E G+ S+ S +L++
Sbjct: 1145 SLERSLEAERASRAERDSALETLQGQLE-EKAQELGHSQSA---------LASAQRELAA 1194
Query: 1828 GSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTS 1887
+ Q +SK +E ++ RQ E + L E++ G
Sbjct: 1195 FRTKVQDHSKAE-----DEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGE-- 1247
Query: 1888 NFYSQGLESIPQLCNE-NRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQEL 1946
S+ L+ + +E ++ L E R LQA+ + S ++ + +LRE +Q L
Sbjct: 1248 ---SKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALRE-------EVQSL 1297
Query: 1947 EKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLF 2006
+E E Q+V + L R+E S E L +L Q++ +K+Q
Sbjct: 1298 REEAEKQRVASENL--------------RQELTSQAERAEELGQELKAWQEKFFQKEQAL 1343
Query: 2007 ESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNN 2066
+LQ E +AL L A L C Q+ + A + R +LEQS Q
Sbjct: 1344 STLQLEHTSTQALVSEL---LPAKHL--CQQLQ-----AEQAAAEKRHREELEQSKQAAG 1393
Query: 2067 CLRLQL 2072
LR +L
Sbjct: 1394 GLRAEL 1399
Score = 59.3 bits (142), Expect = 4e-08
Identities = 276/1386 (19%), Positives = 518/1386 (37%), Gaps = 223/1386 (16%)
Query: 738 PRSTLGDL-----DTVAGLEKELSNAK---EELELMAKKERESQMELSALQSMMAVQEEE 789
P S +GD+ + L+K+L++ + +ELEL + R+ E A +MM + +
Sbjct: 201 PASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDR 260
Query: 790 LQV-----QAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASV 844
L + A+ +E + ++ D + L M+L E + + L E + K+ +
Sbjct: 261 LALLNEKQAASPLEP--KELEELRDKNESLTMRL--HETLKQCQDLKTEKSQMDRKINQL 316
Query: 845 ESQGQEISGNRR------QQLLLMLEGLVDERSR-----LNEALQAERQLYSSLVKFHAH 893
+ ++S R QQL L L +E S+ L + Q E++L ++L
Sbjct: 317 SEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCL 376
Query: 894 PESSE--RDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTST 951
E +E + + Q+E E L+ + G L + +LETL A ++T+ +
Sbjct: 377 EEKNEILQGKLSQLE-EHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQAR 435
Query: 952 EFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRA 1011
+ +E E QQ K+ E+ E Q S SN +E L +
Sbjct: 436 --VEMLETERG----QQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQAS 489
Query: 1012 EFH--QHLEEKRKAEEELKELKAQIEE-----AGFSSVSHIRNTMLSLCLENAE-----L 1059
+ H + + EL L A I++ AG + + L+ L+ E L
Sbjct: 490 QAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGL 549
Query: 1060 KEQMGEAMSD----GWEIEEDKEKGEVM----VETVVTKEGLSESSLQ---AEFRKLQGK 1108
+ Q+ + S +++E EK E + + T E+SL+ A ++L+
Sbjct: 550 RHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEAL 609
Query: 1109 LKNAHNIINLLKEQLVLSSKEGNSKLTPELLVH-----LTSTIERINTELVGSPGKHQHQ 1163
K + +L++QL ++++ +S T L+ +E + V + + QH+
Sbjct: 610 EKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQA-CVETARQEQHE 668
Query: 1164 EEGNVTVRPFPRPQSLDLGATFTVD-AHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQ 1222
+ V L+L A + + +Q +D + +L S + + L +
Sbjct: 669 AQAQVA--------ELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE 720
Query: 1223 CKQRYQDLQEKLLLSEATVFAQANEL-EKYRVMLTGESLVKQDSKQIQVDLQDLGYETCG 1281
K+R D E+ + + A+ L E+++ + K ++ LQ LG
Sbjct: 721 EKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLG--EAH 778
Query: 1282 RSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEE 1341
++E E R E +H + E E L E +A+ ER Q+E
Sbjct: 779 QAETEVLRRELAEAMAAQHTAESEC---EQLVKE-------VAAWRERYE-----DSQQE 823
Query: 1342 FRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAV 1401
YG + ++ + LK + + A + +Q K +V + S+ S ++ +
Sbjct: 824 EAQYGA-----MFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQ----NEL 874
Query: 1402 GTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKL 1461
L + ++ E + A LQ K S + V++LE + K G +++
Sbjct: 875 AELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATS--KEVARLETLVRKAGEQQET 932
Query: 1462 AEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSND 1521
A L+++ AR + + E +G + T+ A ++ + + N+
Sbjct: 933 ASR-----------ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQM-GNE 980
Query: 1522 IDYY----LGQSFREQLAQGSQLTE--RLTSKLSTKDHKSEKDQAGLEPLALRLSRELQE 1575
++ + ++Q +G Q E RLT + ++A L +RL L E
Sbjct: 981 LERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNE 1040
Query: 1576 KEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEK 1635
+ LQ L +HAL++ + L LEA ++ ++
Sbjct: 1041 QRVEFATLQEAL---------AHALTEKEGKDQELAKLRG-LEAAQIKELEELRQTVKQL 1090
Query: 1636 KASPSHSDSIHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGF 1695
K + + H S A S+ + + G K E+ +S Q K+ QA S
Sbjct: 1091 KEQLAKKEKEHASGSGA--QSEAAGRTEPTGPKLEALRAEVS-KLEQQCQKQQEQADS-- 1145
Query: 1696 HFHSIPKLASLPQAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGE 1755
L E S AE L+ LQ QL E
Sbjct: 1146 --------------------------------LERSLEAERASRAERDSALETLQGQLEE 1173
Query: 1756 SASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMR 1815
A + + +A + + + + + Q HS E + +
Sbjct: 1174 KAQELGHSQSALASA---QRELAAFRTKVQDHSKA----------EDEWKAQVARGRQEA 1220
Query: 1816 PQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRL----EESICINDRLREQ 1871
+K S+ L S+ LN + +LE+ GE + L++ + E+S + +RLR
Sbjct: 1221 ERKNSLISSLEEEVSI--LNRQ-----VLEKE-GESKELKRLVMAESEKSQKLEERLRLL 1272
Query: 1872 LEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETES 1931
+++AR +S LRE+ + L+ + + + +E+
Sbjct: 1273 QAETASNSARAAERSS------------------ALREEVQSLREE----AEKQRVASEN 1310
Query: 1932 LREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHK 1991
LR+ L S +EL +EL+ + E +K+Q + + E S Q S L
Sbjct: 1311 LRQELTSQAERAEELGQELKAWQ-------EKFFQKEQALSTLQLEHTSTQALVSELLPA 1363
Query: 1992 LVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEV 2051
L QQ E+ + + EL+ + G + L + IPL ++
Sbjct: 1364 KHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTA 1423
Query: 2052 RALRGQ 2057
+ LR +
Sbjct: 1424 QQLRAE 1429
Score = 53.9 bits (128), Expect = 2e-06
Identities = 257/1318 (19%), Positives = 483/1318 (36%), Gaps = 195/1318 (14%)
Query: 869 ERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSL-ER 927
E S L A LY S + + + + + +Q EL A +L+ L+ G +L E
Sbjct: 89 EGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAEL--AVILKFVLDHEDGLNLNED 146
Query: 928 LNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQN-P 986
L A + + E+ S +H + +++ + L+K ++ N
Sbjct: 147 LENFLQKAPVPSTCSSTFPEELSPP---------SHQAKREIRFLELQKVASSSSGNNFL 197
Query: 987 SFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIR 1046
S SP SPMG D + Q +M L+ + + + E EL E + + E + ++ ++
Sbjct: 198 SGSPASPMG-DILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKD-AQIAMMQ 255
Query: 1047 NTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMV----------ETVVTKEG---- 1092
+ L L L E+ + + E+EE ++K E + + + T++
Sbjct: 256 QRIDRLAL----LNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDR 311
Query: 1093 ----LSESS--LQAEFRKLQGKLKNAHNIINLLKEQLVLSSKEGNSKLTP---------- 1136
LSE + L + R+ L+ + +N L E+ +++E K
Sbjct: 312 KINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQ 371
Query: 1137 ---------ELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGATFTV 1187
E+L S +E ++L +P + + + G+V + ++ L A T
Sbjct: 372 DKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQ 431
Query: 1188 DAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLL-LSEATV-FAQA 1245
+++ R G Q A L H + Q DLQ + LS+A QA
Sbjct: 432 LQARVEMLETER--GQQEA-KLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQA 488
Query: 1246 NELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKE 1305
++ R+ SL + + + +Q E G + E++ + ++
Sbjct: 489 SQAHGARLTAQVASLTSELTT-LNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQ--- 544
Query: 1306 MVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQL 1365
+ QG R SS K E QL + E + + ++ L ++ +A L
Sbjct: 545 --------ASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASL 596
Query: 1366 QNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPD--EDEGWLSDG 1423
+ + ++ L++ + + + +L+ S+ SV ++ LS
Sbjct: 597 RERDAALKQLEALEKEKAAKLEILQQ-----QLQVANEARDSAQTSVTQAQREKAELSRK 651
Query: 1424 TGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQAR 1483
+ A+++ +V++LE QL ++K E+ R A +DQ +
Sbjct: 652 VEELQACVETARQEQHEAQAQVAELELQLRSE--QQKATEKERVAQE--------KDQLQ 701
Query: 1484 E-LSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTE 1542
E L L++ ++ +G R A D ++ + + + T
Sbjct: 702 EQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAE-----------------TR 744
Query: 1543 RLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPSSSHALSD 1602
L + + + E+++AG + L RL + + + EVL+ +L + A++
Sbjct: 745 SLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRREL---------AEAMAA 795
Query: 1603 SHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSSTS 1662
H + S L E+ A + E + EE + + + + + +
Sbjct: 796 QHTAESECEQLVKEVAAWRER---YEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEA 852
Query: 1663 ASQGAKAESNSNPISLPTPQNTPKE--ANQAHSGFHFHSIPKLASLPQAPLPSAPSSFLP 1720
+ A ES+S + + QN E AN A + A L +
Sbjct: 853 KEKVAGIESHSE-LQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAA 911
Query: 1721 FSPTGPLLLGCCETPVVSLAEAQQ----------------ELQMLQKQLGESASTVPPA- 1763
S L ET V E Q+ + + L++Q G + A
Sbjct: 912 TSKEVARL----ETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAAL 967
Query: 1764 ----STATLLSNDLEADSSYYLNSAQPHSPPRG---------TIELGRILEPGYLGSSGK 1810
A + N+LE + + S RG T E GR L + +
Sbjct: 968 QAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAAR 1027
Query: 1811 WDV-MRPQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLR----QRLEESICIN 1865
++ MR Q + + L T + ++ L ++R L + LEE
Sbjct: 1028 AELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTV 1087
Query: 1866 DRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREH 1925
+L+EQL + A G G+ S + + P+L LR + +L+ Q +E
Sbjct: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKL----EALRAEVSKLEQQCQK-QQEQ 1142
Query: 1926 SQETESLREALLSSR----SHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSL 1981
+ E EA +SR S L+ L+ +LE + E L Q+E+ FR +
Sbjct: 1143 ADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDH 1202
Query: 1982 QENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALY----GNSK--------KGLKA 2029
+ + + ++ +Q+ E K L SL+ E+ I G SK + K+
Sbjct: 1203 SKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKS 1262
Query: 2030 YSLD----------ACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLE 2077
L+ A + + S L EV++LR + E+ + LR +L Q E
Sbjct: 1263 QKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAE 1320
Score = 43.9 bits (102), Expect = 0.002
Identities = 107/475 (22%), Positives = 177/475 (37%), Gaps = 79/475 (16%)
Query: 1681 PQNTPKEANQAHSGFHFHSIPKLASLPQAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLA 1740
P+ ++QA F + K+AS S+ ++FL SP P+ +TP +
Sbjct: 165 PEELSPPSHQAKREIRFLELQKVAS------SSSGNNFLSGSPASPMG-DILQTPQFQMR 217
Query: 1741 EAQQEL-------QMLQKQLGESASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGT 1793
+++L L+ +L E+ + A + D LN Q SP
Sbjct: 218 RLKKQLADERSNRDELELELAENRKLLTEKD-AQIAMMQQRIDRLALLNEKQAASP---- 272
Query: 1794 IELGRILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRN 1853
LEP L + +R + S++ L Q DL E R
Sbjct: 273 ------LEPKEL------EELRDKNESLTMRLHETLKQCQ--------DLKTEKSQMDRK 312
Query: 1854 LRQRLEESICINDRLRE------QLEHRLTSTARGRGSTSNFY----SQGLESIPQLCNE 1903
+ Q EE+ ++ +LRE QL+ L + + +Q + + +
Sbjct: 313 INQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQD 372
Query: 1904 NRVLREDNRRLQAQLSHVSREHSQETESLREA---LLSSRSHLQELEKEL------EHQK 1954
+ L E N LQ +LS + SQ ++ + +L L+ L++E Q
Sbjct: 373 KKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQL 432
Query: 1955 VERQQLLEDLREKQQEVL-----HFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFE-- 2007
R ++LE R +Q+ L HF EE+ L + LQ + L Q EE +Q +
Sbjct: 433 QARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAH 492
Query: 2008 ---------SLQSELQIYEALYGNSKKGLKAYSLDACH-QIPLSSDLSHLVAEVRALRGQ 2057
SL SEL A + L A Q L+ L + LR Q
Sbjct: 493 GARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQ 552
Query: 2058 LEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAV 2112
+EQ ++ L+ Q +QQL+ A K + Q + + L +D+A+
Sbjct: 553 VEQL---SSSLK-QKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAAL 603
Score = 38.5 bits (88), Expect = 0.078
Identities = 67/356 (18%), Positives = 144/356 (40%), Gaps = 24/356 (6%)
Query: 1733 ETPVVSLAEAQQELQMLQKQLGE--SASTVPPASTATLLSNDLEADSSYYLNSAQPHSPP 1790
++ + +L++A++EL+ + G +A S T L+ ++ Q
Sbjct: 472 QSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEK 531
Query: 1791 RGTIELGRILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGE 1850
+ +L + L+ S G +R Q +S L + ++ A ++H +
Sbjct: 532 QA--QLAQTLQQQEQASQG----LRHQVEQLSSSLKQKEQQLKEVAEKQEATR-QDHAQQ 584
Query: 1851 IRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLRED 1910
+ + E S+ D +QLE + + + + Q L+ + + +
Sbjct: 585 LATAAEEREASLRERDAALKQLE----ALEKEKAAKLEILQQQLQVANEARDSAQTSVTQ 640
Query: 1911 NRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKEL--EHQKVERQQLLEDLREKQ 1968
+R +A+LS E E+ R+ +++ + ELE +L E QK ++ + +++
Sbjct: 641 AQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQL 700
Query: 1969 QEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLK 2028
QE L +E SL+ L+ + EE+Q+ L++E + +L K+ K
Sbjct: 701 QEQLQALKE--SLKVTKGSLEEEKRRAADALEEQQRCISELKAETR---SLVEQHKRERK 755
Query: 2029 AYSLDACHQIPLSSDLSHL----VAEVRALRGQLEQSIQGNNCLRLQLQQQLESGA 2080
+ + L + L L AE LR +L +++ + + +Q ++ A
Sbjct: 756 ELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA 811
Score = 38.1 bits (87), Expect = 0.10
Identities = 29/135 (21%), Positives = 66/135 (48%), Gaps = 14/135 (10%)
Query: 1904 NRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVE------- 1956
++V ++ + +QAQ E QE + L+ L ++ L + E+ EH K++
Sbjct: 1565 SKVQQQKLKAVQAQ----GGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTH 1620
Query: 1957 ---RQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSEL 2013
++Q ++L+E+ + + ++E L+ RL H+L + +E +Q L +++
Sbjct: 1621 YDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQV 1680
Query: 2014 QIYEALYGNSKKGLK 2028
+ EA ++ + L+
Sbjct: 1681 RSLEAQVAHADQQLR 1695
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 135 bits (340), Expect = 5e-31
Identities = 233/1110 (20%), Positives = 456/1110 (41%), Gaps = 135/1110 (12%)
Query: 54 EVESLKRELQ---DKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQ 110
E+++ + ELQ +++Q + ++E +SQ E E+ Q ETE E E +++
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 111 LLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQ 170
L ++ L + M A +E E++ +L + K + + D+ +Q++ ++ Q
Sbjct: 913 LAAKKQEL-EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE-EQLEEEEAARQKLQ 970
Query: 171 RDK-----RIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKL- 224
+K +I++L + + +LS+E++ LLEE S + EE K + L
Sbjct: 971 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERK----LLEERISDLTTNLAEEEEKAKNLT 1026
Query: 225 ---NSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDG 281
N HE+ I+ EL+ ++++ E + + L++ ++ + E
Sbjct: 1027 KLKNKHESMIS----------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 282 TIQNLKETLKSRERETE----ELYQVIEGQNDTMAKLREML-HQSQLGQLHSSEGTSPAQ 336
I LK L +E E + L I +N+ + K+RE+ H S L + SE + +
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136
Query: 337 QQVALLDLQSALFCSQLEIQKL------QRVVRQKERQLADAKQCVQFVEAAAHESEQQK 390
+ DL L + E++ Q+ +R K Q + E +HE++ Q
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ- 1195
Query: 391 EASWKHNQELRKALQQLQE------ELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS 444
E KH Q + + +QL++ L Q L A+ E+R Q Q + H
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 445 HKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHD----------KAVALERAIDE 494
E +QE + + D E N+ + KL+ + KA+ L + +
Sbjct: 1256 KLEAQVQELQS--KCSDGERARAELNDKV-HKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 495 KFSALEEKEKELRQ-------LRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLE 547
S L++ ++ L++ + +R+ + + L+D L Q++E + ++
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 548 VEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----------LQTSLHDRNKEVEDL 597
+ Q+ E +E R+QKE E++ QQ L+ + + +E++DL
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 598 SATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQ 657
L + +L L++K+R LL++ ++ E +E
Sbjct: 1433 VVDL---------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483
Query: 658 ESQAAAEKLVQALMERNSELQALRQYLGG--RDSLMSQAPISNQQAEVTPT-GCLGKQTD 714
++ + A L +AL E EL+ + L D + S+ + E+ + L Q +
Sbjct: 1484 KALSLARALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542
Query: 715 QGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAG-LEKELSNAKEELELMAKKERESQ 773
+ Q+ +D L A ED + ++ + G E++L E+ E +K R+ Q
Sbjct: 1543 EMKTQLEELED--ELQATEDAKLRLEV--NMQALKGQFERDLQARDEQNE---EKRRQLQ 1595
Query: 774 MELSALQSMMAVQEEELQVQAADMESLTRN-----------IQIKEDLIKDLQMQLVDPE 822
+L ++ + + ++ + AA + L + I+ +E+ IK L+ +
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Query: 823 DIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL-VDERSRLNEALQAE- 880
D +R ++ R+++ + + ++ + + L+ + E L ER+R L+ E
Sbjct: 1656 D---FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1712
Query: 881 --RQLYSSLVKFHAHPESSER--------DRTLQVELEGAQVLRSRLEEVLGRSLERLNR 930
+L SSL +A + R + L+ E + + R+ + ++ + N
Sbjct: 1713 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772
Query: 931 L--ETLAAIGGAAAGDDTEDTSTEFTDSIEE-EAAHHSHQQLVKVALEKSLATVETQNPS 987
L E A +A E + E + E E A S + ALE +A +E Q
Sbjct: 1773 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832
Query: 988 FSPPSPMGGDS----NRCLQEEMLHLRAE---FHQHLEEKRKAEEELKELKAQIEEAGFS 1040
+ S ++ L+E +L + E Q+ E+ K +K+LK Q+EEA
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Query: 1041 S--VSHIRNTMLSLCLENAELKEQMGEAMS 1068
S ++ R + E E E MG ++
Sbjct: 1893 SQRINANRRKLQRELDEATESNEAMGREVN 1922
Score = 135 bits (340), Expect = 5e-31
Identities = 205/950 (21%), Positives = 404/950 (42%), Gaps = 177/950 (18%)
Query: 10 QHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHL 69
+ + DL+ + LK+++ EE +Q ++I ++N LK ++ L+ + D ++ L
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDL 1127
Query: 70 DKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAAL 129
D A ++N+AE +Q + +E E + LE+ + + L + L
Sbjct: 1128 DSERA------ARNKAE--KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1179
Query: 130 VEA-EKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKR---IEELNQSLAAQ 185
+A ++E ++ + K+ + V + +Q+ A A DK +E+ N LA +
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245
R+ L + KQ++ H K++KL ++ + ELQ
Sbjct: 1240 LRV---LGQAKQEVEH------------------KKKKL-------------EAQVQELQ 1265
Query: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE---TLKSRERETEELYQ 302
K E L +K++++ E++ + +G L + +L S+ ++T+EL
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL- 1324
Query: 303 VIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVV 362
Q +T KL QL + +S LQ L Q L+R +
Sbjct: 1325 ----QEETRQKLNVSTKLRQLEEERNS--------------LQDQLDEEMEAKQNLERHI 1366
Query: 363 RQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQE------ELQNKSQ 416
QL+D+K+ +Q + E+ K+ + +E+ QQ +E +L+
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKK---RFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 417 QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL-LQYRDNSDKT-LEANEMLL 474
+L+ + ++ Q Q + +L +QLL E + + +Y D D+ EA E
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-- 1481
Query: 475 EKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSN---- 530
KA++L RA++E A EE E+ + L+ + DL +D + N
Sbjct: 1482 -------ETKALSLARALEEALEAKEELERTNKMLKAEM----EDLVSSKDDVGKNVHEL 1530
Query: 531 EATMQSMESLLRAKGLEVEQLSTTCQ-----------NLQWLKEEMETKFSRWQKEQESI 579
E + +++E+ + ++E+L Q N+Q LK + E ++ E
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 580 IQQLQTSLHDRNKEVED------LSATLLCKLG--------------PGQSEIAEELCQR 619
+QLQ LH+ E+ED L+A KL G+ E ++L ++
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL-RK 1649
Query: 620 LQRK----ERMLQDLLSDRNK---QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALME 672
LQ + +R L+D + R++ E+E + + L + +++ AA QA +E
Sbjct: 1650 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709
Query: 673 RNSELQALRQYLGGRDSLMS-----QAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDST 727
+ + L L GR++L +A I+ + E+ + +QG+M+ S
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL--------EEEQGNMEAMSDRVRK 1761
Query: 728 SLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQME------------ 775
+ E +S +L T ++ +A+++LE K+ R E
Sbjct: 1762 ATQQAEQLS------NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815
Query: 776 LSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAM-----ERL 830
++AL++ +A EE+++ +A + ++ T++++ K+ +K++ +Q+ D + E+
Sbjct: 1816 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG 1875
Query: 831 TQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAE 880
V L+ ++ E + Q I+ NRR+ L+ +DE + NEA+ E
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRK-----LQRELDEATESNEAMGRE 1920
Score = 122 bits (307), Expect = 3e-27
Identities = 272/1265 (21%), Positives = 501/1265 (39%), Gaps = 211/1265 (16%)
Query: 173 KRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTIT 232
KR ++L Q L Q L + + +Q +E Q K + + T
Sbjct: 808 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPL-LQVTRQEEEMQAKEDELQKTKE 866
Query: 233 QQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKS 292
+Q +++ L EL++K Q +LQE+L ++ + + ++ L +
Sbjct: 867 RQQKAENELKELEQKHSQLTEEKNLLQEQL-----------QAETELYAEAEEMRVRLAA 915
Query: 293 RERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQ 352
+++E EE+ +E A+L E + GQ +E AQQ +LDL+ Q
Sbjct: 916 KKQELEEILHEME------ARLEE---EEDRGQQLQAERKKMAQQ---MLDLE-----EQ 958
Query: 353 LEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQ 412
LE ++ R Q E+ A+AK ++ +E + Q N +L K + L+E +
Sbjct: 959 LEEEEAARQKLQLEKVTAEAK--IKKLEDEILVMDDQ-------NNKLSKERKLLEERIS 1009
Query: 413 NKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEM 472
+ + L +E+ ++L + E ++ E L+ + S + LE +
Sbjct: 1010 DLTTNL-----------AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 473 LLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR----QLRLAVRERDHDLERLRDVLS 528
LE H++ L+ I E L +KE+EL+ +L + ++++ L+++R++
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 529 SNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS--------RWQKEQESII 580
+ ++S A+ +Q + L+ LK E+E R ++EQE +
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1178
Query: 581 QQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLE 640
+ R+ E + + ++ ++ EEL ++L++ +R +L D+NKQ LE
Sbjct: 1179 LKKALDEETRSHEAQ------VQEMRQKHAQAVEELTEQLEQFKRAKANL--DKNKQTLE 1230
Query: 641 HE-MEIQGLLQSVSTREQESQAAAEKL---VQALMERNSELQALRQYLGGRDSLMSQAPI 696
E ++ G L+ + +QE + +KL VQ L + S+ + R L + +
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK--------V 1282
Query: 697 SNQQAEV-TPTGCLGK-------------------QTDQGSMQIPSRDDSTSLTAKEDVS 736
Q EV + TG L + Q Q +Q +R T +
Sbjct: 1283 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1342
Query: 737 IPRSTLGD-----LDTVAGLEKELSNAKEELELMAKKERESQMELSALQS---------M 782
R++L D ++ LE+ +S +L KK ++ + AL+
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 783 MAVQEEELQVQAADMESLTRN--IQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREK 840
Q+ E + A D T+N Q +DL+ DL Q ++ +R ++L +
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 841 VASV---ESQGQEISGNRRQQLLLMLEGLVDER-------SRLNEALQAERQ-LYSSL-- 887
++S E E ++ L L ++E R N+ L+AE + L SS
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522
Query: 888 VKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLE-TLAAIGG-----AA 941
V + H E + R L+ ++E + LE+ L + + RLE + A+ G
Sbjct: 1523 VGKNVH-ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1581
Query: 942 AGDDTEDTST--------EFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSP 993
A D+ + E+ +E+E + K LE L +E Q S
Sbjct: 1582 ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641
Query: 994 MGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEEL------KELKAQIEEAGF----SSVS 1043
R LQ +M +F + LE+ R + +E+ E KA+ EA ++
Sbjct: 1642 EAIKQLRKLQAQM----KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1697
Query: 1044 HIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFR 1103
LE EL E++ ++S ++++K + E + + L+ E
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI-----------AQLEEELE 1746
Query: 1104 KLQGKLKNAHNIINLLKEQL-VLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQH 1162
+ QG ++ + + +Q LS++ + T + +ER N EL H
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL----RSKLH 1802
Query: 1163 QEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQ 1222
+ EG V + + A QL+ Q + Q A +T+ L
Sbjct: 1803 EMEGAV------KSKFKSTIAALEAKIAQLEEQVE------QEAREKQAATKSL------ 1844
Query: 1223 CKQRYQDLQEKLLLSEATVFAQANELEKYRVML-TGESLVKQDSKQIQVDLQDLGYETCG 1281
KQ+ + L+E LL E + E+Y+ G + VKQ +Q++ ++
Sbjct: 1845 -KQKDKKLKEILLQVE----DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899
Query: 1282 RSENEAEREETTSPE---CEEHNSLKEMVLMEGLCSEQGRRGSTLAS--SSERKPLENQL 1336
R + + E +E T E N+LK + +G S + S S R+ +EN
Sbjct: 1900 RRKLQRELDEATESNEAMGREVNALKSKL-------RRGNETSFVPSRRSGGRRVIENAD 1952
Query: 1337 GKQEE 1341
G +EE
Sbjct: 1953 GSEEE 1957
Score = 77.0 bits (188), Expect = 2e-13
Identities = 83/424 (19%), Positives = 187/424 (44%), Gaps = 27/424 (6%)
Query: 38 EASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQE 97
E S+ + + E+K ++E L+ ELQ + + +++ L Q E +L+ + E+ +++
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 98 TEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGD 157
+ L L++E + AA L K+ L+ +KG + + +
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 158 QVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLL------EEPTSMEV 211
Q + + L +E+ + E+ + L + QL L + +E
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710
Query: 212 QPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKC 271
+ + EEL L+ ++ ++ +A+L+E++++ + + + +++ K
Sbjct: 1711 EELAEEL--ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR------KA 1762
Query: 272 AQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEG 331
Q++ Q + N T +S ++ E Q +E QN +LR LH+ + G + S
Sbjct: 1763 TQQAEQ-----LSNELATERSTAQKNESARQQLERQN---KELRSKLHEME-GAVKSKFK 1813
Query: 332 TSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKE 391
++ A + + L+ + E Q + ++QK+++L K+ + VE +EQ KE
Sbjct: 1814 STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL---KEILLQVEDERKMAEQYKE 1870
Query: 392 ASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ 451
+ K N +++ +QL EE + +SQ++ A + E+ ++ + + ++ + L+
Sbjct: 1871 QAEKGNARVKQLKRQL-EEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Query: 452 EFRE 455
E
Sbjct: 1930 RGNE 1933
Score = 63.9 bits (154), Expect = 2e-09
Identities = 224/1231 (18%), Positives = 446/1231 (36%), Gaps = 187/1231 (15%)
Query: 832 QEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFH 891
+E + +E + Q+ + N ++L L +E++ L E LQAE +LY+ +
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910
Query: 892 AHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTST 951
+ +++ L L E+ R E +R + L A A
Sbjct: 911 VRLAAKKQE------------LEEILHEMEARLEEEEDRGQQLQAERKKMA-----QQML 953
Query: 952 EFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRA 1011
+ + +EEE A QL KV E + +E + + + L+E + L
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 1012 EFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGW 1071
+L E+ + + L +LK + E S +S + + EL++ + D
Sbjct: 1014 ----NLAEEEEKAKNLTKLKNKHE----SMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 1072 EIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKE--------QL 1123
+ E + + + + E LQA +L ++ +N + ++E Q
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125
Query: 1124 VLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGA 1183
L S+ + L +E + TEL + Q+E R Q +
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK-----REQEV---- 1176
Query: 1184 TFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFA 1243
TV LD +++ + Q +R + +Q + + E+ ++A +
Sbjct: 1177 --TVLKKALDEETRSHE----------AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224
Query: 1244 QANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSL 1303
LEK L GE V +KQ E++ ++ E E
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAKQ--------------EVEHKKKKLEAQVQE------- 1263
Query: 1304 KEMVLMEGLCSEQGRRGSTLASSSER--KPLENQLGKQEEFRVYGKSENILVLRKDIKDL 1361
++ CS+ R + L + +E+ G E GK+ + L KD+ L
Sbjct: 1264 -----LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE--GKA---IKLAKDVASL 1313
Query: 1362 KAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLS 1421
+QLQ+ +++Q + ++S KLR + S + +E
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVST------------KLRQLEEERNSLQDQLDEE------ 1355
Query: 1422 DGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQ 1481
++AK++LE + +S L QL + ++KL + + ++L + +
Sbjct: 1356 ----------MEAKQNLE---RHISTLNIQLSDS--KKKLQD------FASTVEALEEGK 1394
Query: 1482 AR---ELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGS 1538
R E+ L Q+ E + + + +DL+ D L + ++ +
Sbjct: 1395 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1454
Query: 1539 QLT---ERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPS 1595
QL + ++SK + + ++E + E AL L+R L+E L+AK +
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE------ALEAKEELERTNKM 1508
Query: 1596 SSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLS 1655
+ D S ELE + T EE K + ++ A L
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKR----ALETQMEEMKTQLEELEDELQATEDAKLR 1564
Query: 1656 SKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKLASLPQAPLPSAP 1715
+ + Q K + + + QN K Q H + Q L +A
Sbjct: 1565 LEVNM----QALKGQFERD-LQARDEQNEEKR-RQLQRQLHEYETELEDERKQRALAAAA 1618
Query: 1716 SSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGESASTVPPASTATLLSNDLEA 1775
L L ++ + EA ++L+ LQ Q+ + + D A
Sbjct: 1619 KKKLEGDLKDLELQA--DSAIKGREEAIKQLRKLQAQMKDFQREL----------EDARA 1666
Query: 1776 DSSYYLNSAQPHSPPRGTIE--LGRILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQ 1833
+A+ + ++E L ++ E D+ ++ DL +
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQE----------DLAAAERARKQADLEKEELAEE 1716
Query: 1834 LNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQG 1893
L S +G + L++ + +LEE + E + R+ + SN +
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Query: 1894 LESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQ 1953
+ + + + L N+ L+++L + + +S AL + + +LE+++E +
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL---EAKIAQLEEQVEQE 1833
Query: 1954 KVERQQLLEDLREKQQE----VLHFREERLSLQENDSRLQHKLVLLQQ------QCEEKQ 2003
E+Q + L++K ++ +L +ER ++ + + ++Q + EE+
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893
Query: 2004 QLFESLQSELQ--IYEALYGNSKKGLKAYSL 2032
Q + + +LQ + EA N G + +L
Sbjct: 1894 QRINANRRKLQRELDEATESNEAMGREVNAL 1924
Score = 42.7 bits (99), Expect = 0.004
Identities = 53/239 (22%), Positives = 94/239 (39%), Gaps = 7/239 (2%)
Query: 1844 LEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNE 1903
L+E L R R + E+ L E+LE T ST+ + ++
Sbjct: 1123 LQEDLDSERAARNKAEKQ---KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1179
Query: 1904 NRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLED 1963
+ L E+ R +AQ+ + ++H+Q E L E L + L+K + + E L +
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 1964 LREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNS 2023
LR Q ++ L+ LQ K ++ E LQ+E++ + +
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 2024 K-KGLKAYSLDACHQIPLSSDLSHLVAEVRA---LRGQLEQSIQGNNCLRLQLQQQLES 2078
+ K +K A L L E R + +L Q + N L+ QL +++E+
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358
Score = 42.7 bits (99), Expect = 0.004
Identities = 42/208 (20%), Positives = 87/208 (41%), Gaps = 20/208 (9%)
Query: 1909 EDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQ 1968
ED R + ++ ++E+ ++ +SL L+ + L E+ + +E+++L E+L
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Query: 1969 QEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLK 2028
R +LQ+ RL+ ++ L+++ EE+Q E++ ++ L
Sbjct: 1722 SG-------RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774
Query: 2029 AYSLDACHQIPLSSDLSHLVAEVR--------ALRGQLEQSIQGNNCLRLQLQQQLESGA 2080
A L E+R A++ + + +I QL++Q+E A
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 2081 GKASLSPSSINQNFPASTDPGNKQLLLQ 2108
+ + S+ Q D K++LLQ
Sbjct: 1835 REKQAATKSLKQK-----DKKLKEILLQ 1857
Score = 42.0 bits (97), Expect = 0.007
Identities = 61/241 (25%), Positives = 94/241 (39%), Gaps = 56/241 (23%)
Query: 1850 EIRNLRQRLEESICIND-------RLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCN 1902
EI NL Q+ EE D RL+++L+ + R SN + + L
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459
Query: 1903 ENRV---LREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQ 1959
E + ++ R +A+ +RE + SL AL + +ELE+ + K E
Sbjct: 1460 EKNISSKYADERDRAEAE----AREKETKALSLARALEEALEAKEELERTNKMLKAE--- 1512
Query: 1960 LLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEAL 2019
+EDL + +V +N L+ L+ Q EE + E L+ ELQ E
Sbjct: 1513 -MEDLVSSKDDV----------GKNVHELEKSKRALETQMEEMKTQLEELEDELQATE-- 1559
Query: 2020 YGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQG----NNCLRLQLQQQ 2075
DA L ++AL+GQ E+ +Q N R QLQ+Q
Sbjct: 1560 -------------DA---------KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597
Query: 2076 L 2076
L
Sbjct: 1598 L 1598
Score = 38.9 bits (89), Expect = 0.060
Identities = 45/240 (18%), Positives = 104/240 (43%), Gaps = 25/240 (10%)
Query: 1845 EEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNEN 1904
E+ L + + +Q+ E + ++ QL + + Y++ E +L +
Sbjct: 858 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 917
Query: 1905 RVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDL 1964
+ L E ++A+L + Q+ ++ R+ + + +LE++LE ++ RQ+L +
Sbjct: 918 QELEEILHEMEARLEE-EEDRGQQLQAERKKMAQQ---MLDLEEQLEEEEAARQKLQLEK 973
Query: 1965 REKQQEVLHFREERLSLQENDSRLQHKLVLLQQQC----------EEK-------QQLFE 2007
+ ++ +E L + + +++L + LL+++ EEK + E
Sbjct: 974 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033
Query: 2008 SLQSELQIYEALYGNSKKGLKAYSL----DACHQIPLSSDLSHLVAEVRALRGQLEQSIQ 2063
S+ SEL++ S++ L+ DA +DL +AE++ + E+ +Q
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1093
Score = 37.4 bits (85), Expect = 0.17
Identities = 51/239 (21%), Positives = 100/239 (41%), Gaps = 24/239 (10%)
Query: 1850 EIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLRE 1909
++ +L ++LEE +L QLE ++T+ A+ + + I + ++N L +
Sbjct: 951 QMLDLEEQLEEEEAARQKL--QLE-KVTAEAKIKKLE--------DEILVMDDQNNKLSK 999
Query: 1910 DNRRLQAQLSHVSREHSQETESLREALLSSRSH---LQELEKELEHQKVERQQLLEDLRE 1966
+ + L+ ++S ++ ++E E + H + ELE L+ ++ RQ+L + R+
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1059
Query: 1967 KQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKG 2026
+ + F E+ LQ ++ L+ Q +K+ E LQ+ L +
Sbjct: 1060 LEGDASDFHEQIADLQA-------QIAELKMQLAKKE---EELQAALARLDDEIAQKNNA 1109
Query: 2027 LKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASL 2085
LK H L DL A Q + L+ +L+ L+S A + L
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168
Score = 37.4 bits (85), Expect = 0.17
Identities = 50/280 (17%), Positives = 108/280 (38%), Gaps = 19/280 (6%)
Query: 1833 QLNSKPTGADLLEEHLGEIRNLRQRLEESI-CINDRLREQLEHRLTSTARGRGSTSNFYS 1891
Q+ T + LE+ L + + RLE ++ + + L+ R R
Sbjct: 1540 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599
Query: 1892 QGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSR---SHLQELEK 1948
+ + + + ++L+ L + + + EA+ R + +++ ++
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659
Query: 1949 ELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFES 2008
ELE + R ++ +E +++ + + LQE+ + + +Q EK++L E
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER---ARKQADLEKEELAEE 1716
Query: 2009 LQSELQIYEALYGNSKKGLKAYSLDACHQI-PLSSDLSHLVAEVRALRGQLEQ------- 2060
L S L AL + K+ L+A ++ ++ + VR Q EQ
Sbjct: 1717 LASSLSGRNALQ-DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1775
Query: 2061 ---SIQGNNCLRLQLQQQLESGAGKASLSPSSINQNFPAS 2097
+ Q N R QL++Q + K ++ F ++
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815
Score = 32.0 bits (71), Expect = 7.3
Identities = 36/204 (17%), Positives = 78/204 (38%), Gaps = 3/204 (1%)
Query: 1873 EHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLRED---NRRLQAQLSHVSREHSQET 1929
E L T + N + + QL E +L+E L A+ + + +
Sbjct: 858 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 917
Query: 1930 ESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQ 1989
+ L E L + L+E E + + ER+++ + + + ++++ R LQ +
Sbjct: 918 QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 977
Query: 1990 HKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVA 2049
K+ L+ + L E ++ E + L A + L + +++
Sbjct: 978 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1037
Query: 2050 EVRALRGQLEQSIQGNNCLRLQLQ 2073
E+ + E+S Q L+ +L+
Sbjct: 1038 ELEVRLKKEEKSRQELEKLKRKLE 1061
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 135 bits (340), Expect = 5e-31
Identities = 233/1110 (20%), Positives = 456/1110 (41%), Gaps = 135/1110 (12%)
Query: 54 EVESLKRELQ---DKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQ 110
E+++ + ELQ +++Q + ++E +SQ E E+ Q ETE E E +++
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 111 LLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQ 170
L ++ L + M A +E E++ +L + K + + D+ +Q++ ++ Q
Sbjct: 920 LAAKKQEL-EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE-EQLEEEEAARQKLQ 977
Query: 171 RDK-----RIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKL- 224
+K +I++L + + +LS+E++ LLEE S + EE K + L
Sbjct: 978 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERK----LLEERISDLTTNLAEEEEKAKNLT 1033
Query: 225 ---NSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDG 281
N HE+ I+ EL+ ++++ E + + L++ ++ + E
Sbjct: 1034 KLKNKHESMIS----------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 282 TIQNLKETLKSRERETE----ELYQVIEGQNDTMAKLREML-HQSQLGQLHSSEGTSPAQ 336
I LK L +E E + L I +N+ + K+RE+ H S L + SE + +
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143
Query: 337 QQVALLDLQSALFCSQLEIQKL------QRVVRQKERQLADAKQCVQFVEAAAHESEQQK 390
+ DL L + E++ Q+ +R K Q + E +HE++ Q
Sbjct: 1144 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ- 1202
Query: 391 EASWKHNQELRKALQQLQE------ELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS 444
E KH Q + + +QL++ L Q L A+ E+R Q Q + H
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 445 HKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHD----------KAVALERAIDE 494
E +QE + + D E N+ + KL+ + KA+ L + +
Sbjct: 1263 KLEAQVQELQS--KCSDGERARAELNDKV-HKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 495 KFSALEEKEKELRQ-------LRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLE 547
S L++ ++ L++ + +R+ + + L+D L Q++E + ++
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 548 VEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----------LQTSLHDRNKEVEDL 597
+ Q+ E +E R+QKE E++ QQ L+ + + +E++DL
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 598 SATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQ 657
L + +L L++K+R LL++ ++ E +E
Sbjct: 1440 VVDL---------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490
Query: 658 ESQAAAEKLVQALMERNSELQALRQYLGG--RDSLMSQAPISNQQAEVTPT-GCLGKQTD 714
++ + A L +AL E EL+ + L D + S+ + E+ + L Q +
Sbjct: 1491 KALSLARALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 715 QGSMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAG-LEKELSNAKEELELMAKKERESQ 773
+ Q+ +D L A ED + ++ + G E++L E+ E +K R+ Q
Sbjct: 1550 EMKTQLEELED--ELQATEDAKLRLEV--NMQALKGQFERDLQARDEQNE---EKRRQLQ 1602
Query: 774 MELSALQSMMAVQEEELQVQAADMESLTRN-----------IQIKEDLIKDLQMQLVDPE 822
+L ++ + + ++ + AA + L + I+ +E+ IK L+ +
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 823 DIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGL-VDERSRLNEALQAE- 880
D +R ++ R+++ + + ++ + + L+ + E L ER+R L+ E
Sbjct: 1663 D---FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1719
Query: 881 --RQLYSSLVKFHAHPESSER--------DRTLQVELEGAQVLRSRLEEVLGRSLERLNR 930
+L SSL +A + R + L+ E + + R+ + ++ + N
Sbjct: 1720 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779
Query: 931 L--ETLAAIGGAAAGDDTEDTSTEFTDSIEE-EAAHHSHQQLVKVALEKSLATVETQNPS 987
L E A +A E + E + E E A S + ALE +A +E Q
Sbjct: 1780 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Query: 988 FSPPSPMGGDS----NRCLQEEMLHLRAE---FHQHLEEKRKAEEELKELKAQIEEAGFS 1040
+ S ++ L+E +L + E Q+ E+ K +K+LK Q+EEA
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Query: 1041 S--VSHIRNTMLSLCLENAELKEQMGEAMS 1068
S ++ R + E E E MG ++
Sbjct: 1900 SQRINANRRKLQRELDEATESNEAMGREVN 1929
Score = 135 bits (340), Expect = 5e-31
Identities = 205/950 (21%), Positives = 404/950 (42%), Gaps = 177/950 (18%)
Query: 10 QHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHL 69
+ + DL+ + LK+++ EE +Q ++I ++N LK ++ L+ + D ++ L
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDL 1134
Query: 70 DKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAAL 129
D A ++N+AE +Q + +E E + LE+ + + L + L
Sbjct: 1135 DSERA------ARNKAE--KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1186
Query: 130 VEA-EKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKR---IEELNQSLAAQ 185
+A ++E ++ + K+ + V + +Q+ A A DK +E+ N LA +
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245
R+ L + KQ++ H K++KL ++ + ELQ
Sbjct: 1247 LRV---LGQAKQEVEH------------------KKKKL-------------EAQVQELQ 1272
Query: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE---TLKSRERETEELYQ 302
K E L +K++++ E++ + +G L + +L S+ ++T+EL
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL- 1331
Query: 303 VIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVV 362
Q +T KL QL + +S LQ L Q L+R +
Sbjct: 1332 ----QEETRQKLNVSTKLRQLEEERNS--------------LQDQLDEEMEAKQNLERHI 1373
Query: 363 RQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQE------ELQNKSQ 416
QL+D+K+ +Q + E+ K+ + +E+ QQ +E +L+
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKK---RFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 417 QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFREL-LQYRDNSDKT-LEANEMLL 474
+L+ + ++ Q Q + +L +QLL E + + +Y D D+ EA E
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK-- 1488
Query: 475 EKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSN---- 530
KA++L RA++E A EE E+ + L+ + DL +D + N
Sbjct: 1489 -------ETKALSLARALEEALEAKEELERTNKMLKAEM----EDLVSSKDDVGKNVHEL 1537
Query: 531 EATMQSMESLLRAKGLEVEQLSTTCQ-----------NLQWLKEEMETKFSRWQKEQESI 579
E + +++E+ + ++E+L Q N+Q LK + E ++ E
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 580 IQQLQTSLHDRNKEVED------LSATLLCKLG--------------PGQSEIAEELCQR 619
+QLQ LH+ E+ED L+A KL G+ E ++L ++
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL-RK 1656
Query: 620 LQRK----ERMLQDLLSDRNK---QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALME 672
LQ + +R L+D + R++ E+E + + L + +++ AA QA +E
Sbjct: 1657 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716
Query: 673 RNSELQALRQYLGGRDSLMS-----QAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDST 727
+ + L L GR++L +A I+ + E+ + +QG+M+ S
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL--------EEEQGNMEAMSDRVRK 1768
Query: 728 SLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQME------------ 775
+ E +S +L T ++ +A+++LE K+ R E
Sbjct: 1769 ATQQAEQLS------NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822
Query: 776 LSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAM-----ERL 830
++AL++ +A EE+++ +A + ++ T++++ K+ +K++ +Q+ D + E+
Sbjct: 1823 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG 1882
Query: 831 TQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAE 880
V L+ ++ E + Q I+ NRR+ L+ +DE + NEA+ E
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRK-----LQRELDEATESNEAMGRE 1927
Score = 122 bits (307), Expect = 3e-27
Identities = 272/1265 (21%), Positives = 501/1265 (39%), Gaps = 211/1265 (16%)
Query: 173 KRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTIT 232
KR ++L Q L Q L + + +Q +E Q K + + T
Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPL-LQVTRQEEEMQAKEDELQKTKE 873
Query: 233 QQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKS 292
+Q +++ L EL++K Q +LQE+L ++ + + ++ L +
Sbjct: 874 RQQKAENELKELEQKHSQLTEEKNLLQEQL-----------QAETELYAEAEEMRVRLAA 922
Query: 293 RERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQ 352
+++E EE+ +E A+L E + GQ +E AQQ +LDL+ Q
Sbjct: 923 KKQELEEILHEME------ARLEE---EEDRGQQLQAERKKMAQQ---MLDLE-----EQ 965
Query: 353 LEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQ 412
LE ++ R Q E+ A+AK ++ +E + Q N +L K + L+E +
Sbjct: 966 LEEEEAARQKLQLEKVTAEAK--IKKLEDEILVMDDQ-------NNKLSKERKLLEERIS 1016
Query: 413 NKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEM 472
+ + L +E+ ++L + E ++ E L+ + S + LE +
Sbjct: 1017 DLTTNL-----------AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065
Query: 473 LLEKLRQRIHDKAVALERAIDEKFSALEEKEKELR----QLRLAVRERDHDLERLRDVLS 528
LE H++ L+ I E L +KE+EL+ +L + ++++ L+++R++
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125
Query: 529 SNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFS--------RWQKEQESII 580
+ ++S A+ +Q + L+ LK E+E R ++EQE +
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV 1185
Query: 581 QQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLE 640
+ R+ E + + ++ ++ EEL ++L++ +R +L D+NKQ LE
Sbjct: 1186 LKKALDEETRSHEAQ------VQEMRQKHAQAVEELTEQLEQFKRAKANL--DKNKQTLE 1237
Query: 641 HE-MEIQGLLQSVSTREQESQAAAEKL---VQALMERNSELQALRQYLGGRDSLMSQAPI 696
E ++ G L+ + +QE + +KL VQ L + S+ + R L + +
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK--------V 1289
Query: 697 SNQQAEV-TPTGCLGK-------------------QTDQGSMQIPSRDDSTSLTAKEDVS 736
Q EV + TG L + Q Q +Q +R T +
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1349
Query: 737 IPRSTLGD-----LDTVAGLEKELSNAKEELELMAKKERESQMELSALQS---------M 782
R++L D ++ LE+ +S +L KK ++ + AL+
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 783 MAVQEEELQVQAADMESLTRN--IQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREK 840
Q+ E + A D T+N Q +DL+ DL Q ++ +R ++L +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 841 VASV---ESQGQEISGNRRQQLLLMLEGLVDER-------SRLNEALQAERQ-LYSSL-- 887
++S E E ++ L L ++E R N+ L+AE + L SS
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529
Query: 888 VKFHAHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLE-TLAAIGG-----AA 941
V + H E + R L+ ++E + LE+ L + + RLE + A+ G
Sbjct: 1530 VGKNVH-ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQ 1588
Query: 942 AGDDTEDTST--------EFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSP 993
A D+ + E+ +E+E + K LE L +E Q S
Sbjct: 1589 ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
Query: 994 MGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEEL------KELKAQIEEAGF----SSVS 1043
R LQ +M +F + LE+ R + +E+ E KA+ EA ++
Sbjct: 1649 EAIKQLRKLQAQM----KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704
Query: 1044 HIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFR 1103
LE EL E++ ++S ++++K + E + + L+ E
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI-----------AQLEEELE 1753
Query: 1104 KLQGKLKNAHNIINLLKEQL-VLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQH 1162
+ QG ++ + + +Q LS++ + T + +ER N EL H
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL----RSKLH 1809
Query: 1163 QEEGNVTVRPFPRPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQ 1222
+ EG V + + A QL+ Q + Q A +T+ L
Sbjct: 1810 EMEGAV------KSKFKSTIAALEAKIAQLEEQVE------QEAREKQAATKSL------ 1851
Query: 1223 CKQRYQDLQEKLLLSEATVFAQANELEKYRVML-TGESLVKQDSKQIQVDLQDLGYETCG 1281
KQ+ + L+E LL E + E+Y+ G + VKQ +Q++ ++
Sbjct: 1852 -KQKDKKLKEILLQVE----DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906
Query: 1282 RSENEAEREETTSPE---CEEHNSLKEMVLMEGLCSEQGRRGSTLAS--SSERKPLENQL 1336
R + + E +E T E N+LK + +G S + S S R+ +EN
Sbjct: 1907 RRKLQRELDEATESNEAMGREVNALKSKL-------RRGNETSFVPSRRSGGRRVIENAD 1959
Query: 1337 GKQEE 1341
G +EE
Sbjct: 1960 GSEEE 1964
Score = 77.0 bits (188), Expect = 2e-13
Identities = 83/424 (19%), Positives = 187/424 (44%), Gaps = 27/424 (6%)
Query: 38 EASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQE 97
E S+ + + E+K ++E L+ ELQ + + +++ L Q E +L+ + E+ +++
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 98 TEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGD 157
+ L L++E + AA L K+ L+ +KG + + +
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 158 QVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLL------EEPTSMEV 211
Q + + L +E+ + E+ + L + QL L + +E
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717
Query: 212 QPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKC 271
+ + EEL L+ ++ ++ +A+L+E++++ + + + +++ K
Sbjct: 1718 EELAEEL--ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR------KA 1769
Query: 272 AQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEG 331
Q++ Q + N T +S ++ E Q +E QN +LR LH+ + G + S
Sbjct: 1770 TQQAEQ-----LSNELATERSTAQKNESARQQLERQN---KELRSKLHEME-GAVKSKFK 1820
Query: 332 TSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKE 391
++ A + + L+ + E Q + ++QK+++L K+ + VE +EQ KE
Sbjct: 1821 STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL---KEILLQVEDERKMAEQYKE 1877
Query: 392 ASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQ 451
+ K N +++ +QL EE + +SQ++ A + E+ ++ + + ++ + L+
Sbjct: 1878 QAEKGNARVKQLKRQL-EEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Query: 452 EFRE 455
E
Sbjct: 1937 RGNE 1940
Score = 63.9 bits (154), Expect = 2e-09
Identities = 224/1231 (18%), Positives = 446/1231 (36%), Gaps = 187/1231 (15%)
Query: 832 QEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFH 891
+E + +E + Q+ + N ++L L +E++ L E LQAE +LY+ +
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917
Query: 892 AHPESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTST 951
+ +++ L L E+ R E +R + L A A
Sbjct: 918 VRLAAKKQE------------LEEILHEMEARLEEEEDRGQQLQAERKKMA-----QQML 960
Query: 952 EFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRA 1011
+ + +EEE A QL KV E + +E + + + L+E + L
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 1012 EFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGW 1071
+L E+ + + L +LK + E S +S + + EL++ + D
Sbjct: 1021 ----NLAEEEEKAKNLTKLKNKHE----SMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072
Query: 1072 EIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKE--------QL 1123
+ E + + + + E LQA +L ++ +N + ++E Q
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132
Query: 1124 VLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGA 1183
L S+ + L +E + TEL + Q+E R Q +
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK-----REQEV---- 1183
Query: 1184 TFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFA 1243
TV LD +++ + Q +R + +Q + + E+ ++A +
Sbjct: 1184 --TVLKKALDEETRSHE----------AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231
Query: 1244 QANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSL 1303
LEK L GE V +KQ E++ ++ E E
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQ--------------EVEHKKKKLEAQVQE------- 1270
Query: 1304 KEMVLMEGLCSEQGRRGSTLASSSER--KPLENQLGKQEEFRVYGKSENILVLRKDIKDL 1361
++ CS+ R + L + +E+ G E GK+ + L KD+ L
Sbjct: 1271 -----LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE--GKA---IKLAKDVASL 1320
Query: 1362 KAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEGSSPHSVPDEDEGWLS 1421
+QLQ+ +++Q + ++S KLR + S + +E
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVST------------KLRQLEEERNSLQDQLDEE------ 1362
Query: 1422 DGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQDQ 1481
++AK++LE + +S L QL + ++KL + + ++L + +
Sbjct: 1363 ----------MEAKQNLE---RHISTLNIQLSDS--KKKLQD------FASTVEALEEGK 1401
Query: 1482 AR---ELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGS 1538
R E+ L Q+ E + + + +DL+ D L + ++ +
Sbjct: 1402 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1461
Query: 1539 QLT---ERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLDARSLTPS 1595
QL + ++SK + + ++E + E AL L+R L+E L+AK +
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE------ALEAKEELERTNKM 1515
Query: 1596 SSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLS 1655
+ D S ELE + T EE K + ++ A L
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKR----ALETQMEEMKTQLEELEDELQATEDAKLR 1571
Query: 1656 SKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKLASLPQAPLPSAP 1715
+ + Q K + + + QN K Q H + Q L +A
Sbjct: 1572 LEVNM----QALKGQFERD-LQARDEQNEEKR-RQLQRQLHEYETELEDERKQRALAAAA 1625
Query: 1716 SSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGESASTVPPASTATLLSNDLEA 1775
L L ++ + EA ++L+ LQ Q+ + + D A
Sbjct: 1626 KKKLEGDLKDLELQA--DSAIKGREEAIKQLRKLQAQMKDFQREL----------EDARA 1673
Query: 1776 DSSYYLNSAQPHSPPRGTIE--LGRILEPGYLGSSGKWDVMRPQKGSVSGDLSSGSSVYQ 1833
+A+ + ++E L ++ E D+ ++ DL +
Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQE----------DLAAAERARKQADLEKEELAEE 1723
Query: 1834 LNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQG 1893
L S +G + L++ + +LEE + E + R+ + SN +
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Query: 1894 LESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQ 1953
+ + + + L N+ L+++L + + +S AL + + +LE+++E +
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL---EAKIAQLEEQVEQE 1840
Query: 1954 KVERQQLLEDLREKQQE----VLHFREERLSLQENDSRLQHKLVLLQQ------QCEEKQ 2003
E+Q + L++K ++ +L +ER ++ + + ++Q + EE+
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900
Query: 2004 QLFESLQSELQ--IYEALYGNSKKGLKAYSL 2032
Q + + +LQ + EA N G + +L
Sbjct: 1901 QRINANRRKLQRELDEATESNEAMGREVNAL 1931
Score = 42.7 bits (99), Expect = 0.004
Identities = 53/239 (22%), Positives = 94/239 (39%), Gaps = 7/239 (2%)
Query: 1844 LEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNE 1903
L+E L R R + E+ L E+LE T ST+ + ++
Sbjct: 1130 LQEDLDSERAARNKAEKQ---KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1186
Query: 1904 NRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLED 1963
+ L E+ R +AQ+ + ++H+Q E L E L + L+K + + E L +
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 1964 LREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNS 2023
LR Q ++ L+ LQ K ++ E LQ+E++ + +
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 2024 K-KGLKAYSLDACHQIPLSSDLSHLVAEVRA---LRGQLEQSIQGNNCLRLQLQQQLES 2078
+ K +K A L L E R + +L Q + N L+ QL +++E+
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365
Score = 42.7 bits (99), Expect = 0.004
Identities = 42/208 (20%), Positives = 87/208 (41%), Gaps = 20/208 (9%)
Query: 1909 EDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQ 1968
ED R + ++ ++E+ ++ +SL L+ + L E+ + +E+++L E+L
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 1969 QEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLK 2028
R +LQ+ RL+ ++ L+++ EE+Q E++ ++ L
Sbjct: 1729 SG-------RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 2029 AYSLDACHQIPLSSDLSHLVAEVR--------ALRGQLEQSIQGNNCLRLQLQQQLESGA 2080
A L E+R A++ + + +I QL++Q+E A
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 2081 GKASLSPSSINQNFPASTDPGNKQLLLQ 2108
+ + S+ Q D K++LLQ
Sbjct: 1842 REKQAATKSLKQK-----DKKLKEILLQ 1864
Score = 42.0 bits (97), Expect = 0.007
Identities = 61/241 (25%), Positives = 94/241 (39%), Gaps = 56/241 (23%)
Query: 1850 EIRNLRQRLEESICIND-------RLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCN 1902
EI NL Q+ EE D RL+++L+ + R SN + + L
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466
Query: 1903 ENRV---LREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQ 1959
E + ++ R +A+ +RE + SL AL + +ELE+ + K E
Sbjct: 1467 EKNISSKYADERDRAEAE----AREKETKALSLARALEEALEAKEELERTNKMLKAE--- 1519
Query: 1960 LLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEAL 2019
+EDL + +V +N L+ L+ Q EE + E L+ ELQ E
Sbjct: 1520 -MEDLVSSKDDV----------GKNVHELEKSKRALETQMEEMKTQLEELEDELQATE-- 1566
Query: 2020 YGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQG----NNCLRLQLQQQ 2075
DA L ++AL+GQ E+ +Q N R QLQ+Q
Sbjct: 1567 -------------DA---------KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604
Query: 2076 L 2076
L
Sbjct: 1605 L 1605
Score = 38.9 bits (89), Expect = 0.060
Identities = 45/240 (18%), Positives = 104/240 (43%), Gaps = 25/240 (10%)
Query: 1845 EEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNEN 1904
E+ L + + +Q+ E + ++ QL + + Y++ E +L +
Sbjct: 865 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 924
Query: 1905 RVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDL 1964
+ L E ++A+L + Q+ ++ R+ + + +LE++LE ++ RQ+L +
Sbjct: 925 QELEEILHEMEARLEE-EEDRGQQLQAERKKMAQQ---MLDLEEQLEEEEAARQKLQLEK 980
Query: 1965 REKQQEVLHFREERLSLQENDSRLQHKLVLLQQQC----------EEK-------QQLFE 2007
+ ++ +E L + + +++L + LL+++ EEK + E
Sbjct: 981 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
Query: 2008 SLQSELQIYEALYGNSKKGLKAYSL----DACHQIPLSSDLSHLVAEVRALRGQLEQSIQ 2063
S+ SEL++ S++ L+ DA +DL +AE++ + E+ +Q
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1100
Score = 37.4 bits (85), Expect = 0.17
Identities = 51/239 (21%), Positives = 100/239 (41%), Gaps = 24/239 (10%)
Query: 1850 EIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLRE 1909
++ +L ++LEE +L QLE ++T+ A+ + + I + ++N L +
Sbjct: 958 QMLDLEEQLEEEEAARQKL--QLE-KVTAEAKIKKLE--------DEILVMDDQNNKLSK 1006
Query: 1910 DNRRLQAQLSHVSREHSQETESLREALLSSRSH---LQELEKELEHQKVERQQLLEDLRE 1966
+ + L+ ++S ++ ++E E + H + ELE L+ ++ RQ+L + R+
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1066
Query: 1967 KQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKG 2026
+ + F E+ LQ ++ L+ Q +K+ E LQ+ L +
Sbjct: 1067 LEGDASDFHEQIADLQA-------QIAELKMQLAKKE---EELQAALARLDDEIAQKNNA 1116
Query: 2027 LKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGKASL 2085
LK H L DL A Q + L+ +L+ L+S A + L
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1175
Score = 37.4 bits (85), Expect = 0.17
Identities = 50/280 (17%), Positives = 108/280 (38%), Gaps = 19/280 (6%)
Query: 1833 QLNSKPTGADLLEEHLGEIRNLRQRLEESI-CINDRLREQLEHRLTSTARGRGSTSNFYS 1891
Q+ T + LE+ L + + RLE ++ + + L+ R R
Sbjct: 1547 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606
Query: 1892 QGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSR---SHLQELEK 1948
+ + + + ++L+ L + + + EA+ R + +++ ++
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666
Query: 1949 ELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFES 2008
ELE + R ++ +E +++ + + LQE+ + + +Q EK++L E
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER---ARKQADLEKEELAEE 1723
Query: 2009 LQSELQIYEALYGNSKKGLKAYSLDACHQI-PLSSDLSHLVAEVRALRGQLEQ------- 2060
L S L AL + K+ L+A ++ ++ + VR Q EQ
Sbjct: 1724 LASSLSGRNALQ-DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1782
Query: 2061 ---SIQGNNCLRLQLQQQLESGAGKASLSPSSINQNFPAS 2097
+ Q N R QL++Q + K ++ F ++
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822
Score = 32.0 bits (71), Expect = 7.3
Identities = 36/204 (17%), Positives = 78/204 (38%), Gaps = 3/204 (1%)
Query: 1873 EHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLRED---NRRLQAQLSHVSREHSQET 1929
E L T + N + + QL E +L+E L A+ + + +
Sbjct: 865 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 924
Query: 1930 ESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQ 1989
+ L E L + L+E E + + ER+++ + + + ++++ R LQ +
Sbjct: 925 QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 984
Query: 1990 HKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVA 2049
K+ L+ + L E ++ E + L A + L + +++
Sbjct: 985 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1044
Query: 2050 EVRALRGQLEQSIQGNNCLRLQLQ 2073
E+ + E+S Q L+ +L+
Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKLE 1068
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.125 0.335
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,841,555
Number of Sequences: 37866
Number of extensions: 4068627
Number of successful extensions: 45581
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 459
Number of HSP's successfully gapped in prelim test: 1426
Number of HSP's that attempted gapping in prelim test: 18395
Number of HSP's gapped (non-prelim): 15314
length of query: 2346
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2227
effective length of database: 13,741,464
effective search space: 30602240328
effective search space used: 30602240328
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.