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Search of human proteins with 110349767
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110349767 calcium channel, voltage-dependent, L type, alpha
1S subunit [Homo sapiens]
(1873 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110349767 calcium channel, voltage-dependent, L type, alpha 1... 3760 0.0
gi|193788540 calcium channel, voltage-dependent, L type, alpha 1... 2301 0.0
gi|193788544 calcium channel, voltage-dependent, L type, alpha 1... 2300 0.0
gi|193794830 calcium channel, voltage-dependent, L type, alpha 1... 2299 0.0
gi|193788732 calcium channel, voltage-dependent, L type, alpha 1... 2299 0.0
gi|193788538 calcium channel, voltage-dependent, L type, alpha 1... 2298 0.0
gi|193794828 calcium channel, voltage-dependent, L type, alpha 1... 2289 0.0
gi|193788720 calcium channel, voltage-dependent, L type, alpha 1... 2289 0.0
gi|193788724 calcium channel, voltage-dependent, L type, alpha 1... 2288 0.0
gi|120433602 calcium channel, voltage-dependent, L type, alpha 1... 2286 0.0
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1... 2283 0.0
gi|193788542 calcium channel, voltage-dependent, L type, alpha 1... 2282 0.0
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1... 2281 0.0
gi|193788526 calcium channel, voltage-dependent, L type, alpha 1... 2275 0.0
gi|193788528 calcium channel, voltage-dependent, L type, alpha 1... 2274 0.0
gi|193788532 calcium channel, voltage-dependent, L type, alpha 1... 2273 0.0
gi|193788728 calcium channel, voltage-dependent, L type, alpha 1... 2273 0.0
gi|193794832 calcium channel, voltage-dependent, L type, alpha 1... 2271 0.0
gi|193788530 calcium channel, voltage-dependent, L type, alpha 1... 2271 0.0
gi|193788536 calcium channel, voltage-dependent, L type, alpha 1... 2270 0.0
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1... 2270 0.0
gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D ... 2269 0.0
gi|192807300 calcium channel, voltage-dependent, L type, alpha 1... 2268 0.0
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1... 2266 0.0
gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F... 2084 0.0
gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo s... 737 0.0
gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B ... 735 0.0
gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E... 729 0.0
gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo s... 729 0.0
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s... 427 e-119
>gi|110349767 calcium channel, voltage-dependent, L type, alpha 1S
subunit [Homo sapiens]
Length = 1873
Score = 3760 bits (9751), Expect = 0.0
Identities = 1873/1873 (100%), Positives = 1873/1873 (100%)
Query: 1 MEPSSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLT 60
MEPSSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLT
Sbjct: 1 MEPSSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLT 60
Query: 61 IFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRS 120
IFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRS
Sbjct: 61 IFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRS 120
Query: 121 GWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVP 180
GWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVP
Sbjct: 121 GWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVP 180
Query: 181 SLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENE 240
SLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENE
Sbjct: 181 SLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENE 240
Query: 241 EPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYW 300
EPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYW
Sbjct: 241 EPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYW 300
Query: 301 VNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLD 360
VNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLD
Sbjct: 301 VNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLD 360
Query: 361 EDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFIRHWRQWNRI 420
EDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFIRHWRQWNRI
Sbjct: 361 EDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFIRHWRQWNRI 420
Query: 421 FRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEML 480
FRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEML
Sbjct: 421 FRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEML 480
Query: 481 MKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITK 540
MKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITK
Sbjct: 481 MKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITK 540
Query: 541 YWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNF 600
YWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNF
Sbjct: 541 YWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNF 600
Query: 601 PQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIA 660
PQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIA
Sbjct: 601 PQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIA 660
Query: 661 VDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKSEEEKSTMAKKLEQKPKGEGIPTTAKL 720
VDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKSEEEKSTMAKKLEQKPKGEGIPTTAKL
Sbjct: 661 VDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKSEEEKSTMAKKLEQKPKGEGIPTTAKL 720
Query: 721 KIDEFESNVNEVKDPYPSADFPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFF 780
KIDEFESNVNEVKDPYPSADFPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFF
Sbjct: 721 KIDEFESNVNEVKDPYPSADFPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFF 780
Query: 781 IFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFT 840
IFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFT
Sbjct: 781 IFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFT 840
Query: 841 SVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLR 900
SVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLR
Sbjct: 841 SVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLR 900
Query: 901 VLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDL 960
VLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDL
Sbjct: 901 VLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDL 960
Query: 961 SKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLL 1020
SKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLL
Sbjct: 961 SKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLL 1020
Query: 1021 YKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCE 1080
YKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCE
Sbjct: 1021 YKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCE 1080
Query: 1081 LDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHY 1140
LDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHY
Sbjct: 1081 LDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHY 1140
Query: 1141 NQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILS 1200
NQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILS
Sbjct: 1141 NQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILS 1200
Query: 1201 EIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTF 1260
EIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTF
Sbjct: 1201 EIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTF 1260
Query: 1261 IKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCA 1320
IKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCA
Sbjct: 1261 IKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCA 1320
Query: 1321 TGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVI 1380
TGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVI
Sbjct: 1321 TGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVI 1380
Query: 1381 MDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCP 1440
MDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCP
Sbjct: 1381 MDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCP 1440
Query: 1441 HRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKR 1500
HRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKR
Sbjct: 1441 HRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKR 1500
Query: 1501 TSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDIVQIQAGLR 1560
TSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDIVQIQAGLR
Sbjct: 1501 TSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDIVQIQAGLR 1560
Query: 1561 TIEEEAAPEICRTVSGDLAAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPP 1620
TIEEEAAPEICRTVSGDLAAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPP
Sbjct: 1561 TIEEEAAPEICRTVSGDLAAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPP 1620
Query: 1621 VMANQRPLQFAEIEMEEMESPVFLEDFPQDPRTNPLARANTNNANANVAYGNSNHSNSHV 1680
VMANQRPLQFAEIEMEEMESPVFLEDFPQDPRTNPLARANTNNANANVAYGNSNHSNSHV
Sbjct: 1621 VMANQRPLQFAEIEMEEMESPVFLEDFPQDPRTNPLARANTNNANANVAYGNSNHSNSHV 1680
Query: 1681 FSSVHYEREFPEETETPATRGRALGQPCRVLGPHSKPCVEMLKGLLTQRAMPRGQAPPAP 1740
FSSVHYEREFPEETETPATRGRALGQPCRVLGPHSKPCVEMLKGLLTQRAMPRGQAPPAP
Sbjct: 1681 FSSVHYEREFPEETETPATRGRALGQPCRVLGPHSKPCVEMLKGLLTQRAMPRGQAPPAP 1740
Query: 1741 CQCPRVESSMPEDRKSSTPGSLHEETPHSRSTRENTSRCSAPATALLIQKALVRGGLGTL 1800
CQCPRVESSMPEDRKSSTPGSLHEETPHSRSTRENTSRCSAPATALLIQKALVRGGLGTL
Sbjct: 1741 CQCPRVESSMPEDRKSSTPGSLHEETPHSRSTRENTSRCSAPATALLIQKALVRGGLGTL 1800
Query: 1801 AADANFIMATGQALADACQMEPEEVEIMATELLKGREAPEGMASSLGCLNLGSSLGSLDQ 1860
AADANFIMATGQALADACQMEPEEVEIMATELLKGREAPEGMASSLGCLNLGSSLGSLDQ
Sbjct: 1801 AADANFIMATGQALADACQMEPEEVEIMATELLKGREAPEGMASSLGCLNLGSSLGSLDQ 1860
Query: 1861 HQGSQETLIPPRL 1873
HQGSQETLIPPRL
Sbjct: 1861 HQGSQETLIPPRL 1873
>gi|193788540 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 16 [Homo sapiens]
Length = 2138
Score = 2301 bits (5963), Expect = 0.0
Identities = 1178/1714 (68%), Positives = 1385/1714 (80%), Gaps = 60/1714 (3%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNML 871
SS +LAAEDP++ S RN IL +FDI FT++FT+EI LKMT YGAFLHKGSFCRNYFN+L
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL 972
Query: 872 DLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNI 931
DLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TIGNI
Sbjct: 973 DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1032
Query: 932 VLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWV 991
V+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G Y YKDG+ ++ R W
Sbjct: 1033 VIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWE 1092
Query: 992 HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIIL 1051
+S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED GPIYN RVE++IFFIIYII+
Sbjct: 1093 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 1152
Query: 1052 IAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQV 1111
IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKN +QY+V
Sbjct: 1153 IAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKV 1212
Query: 1112 WYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMA 1171
WY+V S+YFEYLMF LI+LNTICL MQHY QS +ILN+ FT +FT+EMILKL+A
Sbjct: 1213 WYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARIS 1231
FK +GYF DPWNVFDFLIVIGSIIDVILSE + + C +++ +E++RIS
Sbjct: 1273 FKPKGYFSDPWNVFDFLIVIGSIIDVILSETN----PAEHTQC----SPSMNAEENSRIS 1324
Query: 1232 SAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGK 1291
FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGK
Sbjct: 1325 ITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGK 1384
Query: 1292 IALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE--E 1349
IAL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LAC GK C PES+ + E
Sbjct: 1385 IALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGE 1444
Query: 1350 YTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1409
CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IWAEY
Sbjct: 1445 TPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY 1504
Query: 1410 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469
DPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1505 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFA 1564
Query: 1470 LVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLI 1529
LVRTAL+IKTEGN EQANEELRAIIKKIWKRTSMKLLDQV+PP GDDEVTVGKFYATFLI
Sbjct: 1565 LVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLI 1624
Query: 1530 QEHFRKFMKRQEE-YYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAM 1588
QE+FRKF KR+E+ G +++ + +QAGLRT+ + PEI R +SGDL AEEEL++AM
Sbjct: 1625 QEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTL-HDIGPEIRRAISGDLTAEEELDKAM 1683
Query: 1589 ---VEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMANQRPLQF--AEIEMEEMESP 1641
V AA E+ IFRR GGLFG ++ + ++ P QRPL A + ESP
Sbjct: 1684 KEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESP 1743
Query: 1642 ----VFLEDFPQDPRTNPLARANTNNANANVAYG 1671
+ F ++ + AN NNAN N A G
Sbjct: 1744 SHEKLVDSTFTPSSYSSTGSNANINNAN-NTALG 1776
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 1965 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2024
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2025 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2084
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2085 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2115
>gi|193788544 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 19 [Homo sapiens]
Length = 2135
Score = 2300 bits (5960), Expect = 0.0
Identities = 1175/1713 (68%), Positives = 1382/1713 (80%), Gaps = 61/1713 (3%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPS 243
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + ++PS
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY----NQEGIAAEDDPS 311
Query: 244 PCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVN 302
PCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWVN
Sbjct: 312 PCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVN 370
Query: 303 DAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDED 362
DA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+ED
Sbjct: 371 DAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED 430
Query: 363 LRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN----- 405
L+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 431 LKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARL 490
Query: 406 ----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLT 461
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WLT
Sbjct: 491 AHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLT 550
Query: 462 RLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTP 521
+QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+P
Sbjct: 551 EVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSP 610
Query: 522 LGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLF 581
LGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQLF
Sbjct: 611 LGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF 670
Query: 582 GGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYF 641
GG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIYF
Sbjct: 671 GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYF 730
Query: 642 IILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--EK 698
IILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E EK
Sbjct: 731 IILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEK 790
Query: 699 STMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPEI 752
+ + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE+
Sbjct: 791 PAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEM 850
Query: 753 PLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLS 812
P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILLS
Sbjct: 851 PVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLS 910
Query: 813 SAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLD 872
S +LAAEDP++ S RN IL +FDI FT++FT+EI LKMT YGAFLHKGSFCRNYFN+LD
Sbjct: 911 SISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILD 970
Query: 873 LLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIV 932
LLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TIGNIV
Sbjct: 971 LLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIV 1030
Query: 933 LVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVH 992
+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G Y YKDG+ ++ R W +
Sbjct: 1031 IVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWEN 1090
Query: 993 SDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILI 1052
S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED GPIYN RVE++IFFIIYII+I
Sbjct: 1091 SKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIII 1150
Query: 1053 AFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVW 1112
AFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKN +QY+VW
Sbjct: 1151 AFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVW 1210
Query: 1113 YIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAF 1172
Y+V S+YFEYLMF LI+LNTICL MQHY QS +ILN+ FT +FT+EMILKL+AF
Sbjct: 1211 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF 1270
Query: 1173 KARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISS 1232
K +GYF DPWNVFDFLIVIGSIIDVILSE + + C +++ +E++RIS
Sbjct: 1271 KPKGYFSDPWNVFDFLIVIGSIIDVILSETN----PAEHTQC----SPSMNAEENSRISI 1322
Query: 1233 AFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKI 1292
FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKI
Sbjct: 1323 TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI 1382
Query: 1293 ALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE--EY 1350
AL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LAC GK C PES+ + E
Sbjct: 1383 ALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGET 1442
Query: 1351 TCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYD 1410
CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IWAEYD
Sbjct: 1443 PCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYD 1502
Query: 1411 PEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFAL 1470
PEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLFAL
Sbjct: 1503 PEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFAL 1562
Query: 1471 VRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQ 1530
VRTAL+IKTEGN EQANEELRAIIKKIWKRTSMKLLDQV+PP GDDEVTVGKFYATFLIQ
Sbjct: 1563 VRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQ 1622
Query: 1531 EHFRKFMKRQEE-YYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAM- 1588
E+FRKF KR+E+ G +++ + +QAGLRT+ + PEI R +SGDL AEEEL++AM
Sbjct: 1623 EYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTL-HDIGPEIRRAISGDLTAEEELDKAMK 1681
Query: 1589 --VEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMANQRPLQF--AEIEMEEMESP- 1641
V AA E+ IFRR GGLFG ++ + ++ P QRPL A + ESP
Sbjct: 1682 EAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPS 1741
Query: 1642 ---VFLEDFPQDPRTNPLARANTNNANANVAYG 1671
+ F ++ + AN NNAN N A G
Sbjct: 1742 HEKLVDSTFTPSSYSSTGSNANINNAN-NTALG 1773
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 1962 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2021
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2022 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2081
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2082 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2112
>gi|193794830 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 10 [Homo sapiens]
Length = 2155
Score = 2299 bits (5958), Expect = 0.0
Identities = 1177/1723 (68%), Positives = 1386/1723 (80%), Gaps = 61/1723 (3%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNML 871
SS +LAAEDP++ S RN IL + D FTS+FT+EI+LKMT YGAFLHKGSFCRNYFN+L
Sbjct: 913 SSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL 972
Query: 872 DLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNI 931
DLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TIGNI
Sbjct: 973 DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1032
Query: 932 VLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWV 991
V+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G Y YKDG+ ++ R W
Sbjct: 1033 VIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWE 1092
Query: 992 HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIIL 1051
+S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED GPIYN RVE++IFFIIYII+
Sbjct: 1093 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 1152
Query: 1052 IAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQV 1111
IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKN +QY+V
Sbjct: 1153 IAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKV 1212
Query: 1112 WYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMA 1171
WY+V S+YFEYLMF LI+LNTICL MQHY QS +ILN+ FT +FT+EMILKL+A
Sbjct: 1213 WYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNV--------- 1222
FK +GYF DPWNVFDFLIVIGSIIDVILSE + + + + G++
Sbjct: 1273 FKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVN 1332
Query: 1223 DPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYA 1282
+ +E++RIS FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLIVMLFFIYA
Sbjct: 1333 NAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYA 1392
Query: 1283 VIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPES 1342
VIGMQ+FGKIAL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LAC GK C PES
Sbjct: 1393 VIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPES 1452
Query: 1343 DYAPGE--EYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLD 1400
+ + E CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLD
Sbjct: 1453 EPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLD 1512
Query: 1401 EFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGT 1460
EFK IWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGT
Sbjct: 1513 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGT 1572
Query: 1461 VTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTV 1520
V FNATLFALVRTAL+IKTEGN EQANEELRAIIKKIWKRTSMKLLDQV+PP GDDEVTV
Sbjct: 1573 VMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTV 1632
Query: 1521 GKFYATFLIQEHFRKFMKRQEE-YYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLA 1579
GKFYATFLIQE+FRKF KR+E+ G +++ + +QAGLRT+ + PEI R +SGDL
Sbjct: 1633 GKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTL-HDIGPEIRRAISGDLT 1691
Query: 1580 AEEELERAM---VEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMANQRPLQF--AE 1632
AEEEL++AM V AA E+ IFRR GGLFG ++ + ++ P QRPL A
Sbjct: 1692 AEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAG 1751
Query: 1633 IEMEEMESP----VFLEDFPQDPRTNPLARANTNNANANVAYG 1671
+ ESP + F ++ + AN NNAN N A G
Sbjct: 1752 SSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNAN-NTALG 1793
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 1982 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2041
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2042 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2101
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2102 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2132
>gi|193788732 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 5 [Homo sapiens]
Length = 2166
Score = 2299 bits (5957), Expect = 0.0
Identities = 1180/1734 (68%), Positives = 1389/1734 (80%), Gaps = 72/1734 (4%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNML 871
SS +LAAEDP++ S RN IL +FDI FT++FT+EI LKMT YGAFLHKGSFCRNYFN+L
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL 972
Query: 872 DLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNI 931
DLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TIGNI
Sbjct: 973 DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1032
Query: 932 VLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWV 991
V+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G Y YKDG+ ++ R W
Sbjct: 1033 VIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWE 1092
Query: 992 HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIIL 1051
+S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED GPIYN RVE++IFFIIYII+
Sbjct: 1093 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 1152
Query: 1052 IAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQV 1111
IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKN +QY+V
Sbjct: 1153 IAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKV 1212
Query: 1112 WYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMA 1171
WY+V S+YFEYLMF LI+LNTICL MQHY QS +ILN+ FT +FT+EMILKL+A
Sbjct: 1213 WYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASS----GGLYCLGG---------- 1217
FK +GYF DPWNVFDFLIVIGSIIDVILSE + + + L +G
Sbjct: 1273 FKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVN 1332
Query: 1218 -----GCG-NVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVA 1271
C +++ +E++RIS FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVA
Sbjct: 1333 PAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1392
Query: 1272 LLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLA 1331
LLIVMLFFIYAVIGMQ+FGKIAL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LA
Sbjct: 1393 LLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLA 1452
Query: 1332 CSYGKLCDPESDYAPGE--EYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTR 1389
C GK C PES+ + E CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTR
Sbjct: 1453 CMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTR 1512
Query: 1390 DWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLV 1449
DWSILGPHHLDEFK IWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV
Sbjct: 1513 DWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV 1572
Query: 1450 GMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQV 1509
MNMPLNSDGTV FNATLFALVRTAL+IKTEGN EQANEELRAIIKKIWKRTSMKLLDQV
Sbjct: 1573 SMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQV 1632
Query: 1510 IPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEE-YYGYRPKKDIVQIQAGLRTIEEEAAP 1568
+PP GDDEVTVGKFYATFLIQE+FRKF KR+E+ G +++ + +QAGLRT+ + P
Sbjct: 1633 VPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTL-HDIGP 1691
Query: 1569 EICRTVSGDLAAEEELERAM---VEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMA 1623
EI R +SGDL AEEEL++AM V AA E+ IFRR GGLFG ++ + ++ P
Sbjct: 1692 EIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFT 1751
Query: 1624 NQRPLQF--AEIEMEEMESP----VFLEDFPQDPRTNPLARANTNNANANVAYG 1671
QRPL A + ESP + F ++ + AN NNAN N A G
Sbjct: 1752 TQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNAN-NTALG 1804
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 1993 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2052
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2053 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2112
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2113 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2143
>gi|193788538 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 15 [Homo sapiens]
Length = 2138
Score = 2298 bits (5954), Expect = 0.0
Identities = 1177/1714 (68%), Positives = 1384/1714 (80%), Gaps = 60/1714 (3%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNML 871
SS +LAAEDP++ S RN IL + D FTS+FT+EI+LKMT YGAFLHKGSFCRNYFN+L
Sbjct: 913 SSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL 972
Query: 872 DLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNI 931
DLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TIGNI
Sbjct: 973 DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1032
Query: 932 VLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWV 991
V+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G Y YKDG+ ++ R W
Sbjct: 1033 VIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWE 1092
Query: 992 HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIIL 1051
+S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED GPIYN RVE++IFFIIYII+
Sbjct: 1093 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 1152
Query: 1052 IAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQV 1111
IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKN +QY+V
Sbjct: 1153 IAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKV 1212
Query: 1112 WYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMA 1171
WY+V S+YFEYLMF LI+LNTICL MQHY QS +ILN+ FT +FT+EMILKL+A
Sbjct: 1213 WYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARIS 1231
FK +GYF DPWNVFDFLIVIGSIIDVILSE + + C +++ +E++RIS
Sbjct: 1273 FKPKGYFSDPWNVFDFLIVIGSIIDVILSETN----PAEHTQC----SPSMNAEENSRIS 1324
Query: 1232 SAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGK 1291
FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGK
Sbjct: 1325 ITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGK 1384
Query: 1292 IALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE--E 1349
IAL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LAC GK C PES+ + E
Sbjct: 1385 IALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGE 1444
Query: 1350 YTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1409
CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IWAEY
Sbjct: 1445 TPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY 1504
Query: 1410 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469
DPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1505 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFA 1564
Query: 1470 LVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLI 1529
LVRTAL+IKTEGN EQANEELRAIIKKIWKRTSMKLLDQV+PP GDDEVTVGKFYATFLI
Sbjct: 1565 LVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLI 1624
Query: 1530 QEHFRKFMKRQEE-YYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAM 1588
QE+FRKF KR+E+ G +++ + +QAGLRT+ + PEI R +SGDL AEEEL++AM
Sbjct: 1625 QEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTL-HDIGPEIRRAISGDLTAEEELDKAM 1683
Query: 1589 ---VEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMANQRPLQF--AEIEMEEMESP 1641
V AA E+ IFRR GGLFG ++ + ++ P QRPL A + ESP
Sbjct: 1684 KEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESP 1743
Query: 1642 ----VFLEDFPQDPRTNPLARANTNNANANVAYG 1671
+ F ++ + AN NNAN N A G
Sbjct: 1744 SHEKLVDSTFTPSSYSSTGSNANINNAN-NTALG 1776
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 1965 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2024
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2025 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2084
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2085 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2115
>gi|193794828 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 7 [Homo sapiens]
Length = 2157
Score = 2290 bits (5933), Expect = 0.0
Identities = 1178/1733 (67%), Positives = 1385/1733 (79%), Gaps = 79/1733 (4%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNML 871
SS +LAAEDP++ S RN IL +FDI FT++FT+EI LKMT YGAFLHKGSFCRNYFN+L
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL 972
Query: 872 DLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNI 931
DLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TIGNI
Sbjct: 973 DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1032
Query: 932 VLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWV 991
V+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G Y YKDG+ ++ R W
Sbjct: 1033 VIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWE 1092
Query: 992 HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIIL 1051
+S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED GPIYN RVE++IFFIIYII+
Sbjct: 1093 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 1152
Query: 1052 IAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQV 1111
IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKN +QY+V
Sbjct: 1153 IAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKV 1212
Query: 1112 WYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMA 1171
WY+V S+YFEYLMF LI+LNTICL MQHY QS +ILN+ FT +FT+EMILKL+A
Sbjct: 1213 WYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARIS 1231
FK +GYF DPWNVFDFLIVIGSIIDVILSE + + C +++ +E++RIS
Sbjct: 1273 FKPKGYFSDPWNVFDFLIVIGSIIDVILSETN----PAEHTQC----SPSMNAEENSRIS 1324
Query: 1232 SAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGK 1291
FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGK
Sbjct: 1325 ITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGK 1384
Query: 1292 IALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE--E 1349
IAL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LAC GK C PES+ + E
Sbjct: 1385 IALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGE 1444
Query: 1350 YTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1409
CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IWAEY
Sbjct: 1445 TPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY 1504
Query: 1410 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469
DPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1505 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFA 1564
Query: 1470 LVRTALKIKTE-------------------GNFEQANEELRAIIKKIWKRTSMKLLDQVI 1510
LVRTAL+IKTE GN EQANEELRAIIKKIWKRTSMKLLDQV+
Sbjct: 1565 LVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVV 1624
Query: 1511 PPIGDDEVTVGKFYATFLIQEHFRKFMKRQEE-YYGYRPKKDIVQIQAGLRTIEEEAAPE 1569
PP GDDEVTVGKFYATFLIQE+FRKF KR+E+ G +++ + +QAGLRT+ + PE
Sbjct: 1625 PPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTL-HDIGPE 1683
Query: 1570 ICRTVSGDLAAEEELERAM---VEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMAN 1624
I R +SGDL AEEEL++AM V AA E+ IFRR GGLFG ++ + ++ P
Sbjct: 1684 IRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTT 1743
Query: 1625 QRPLQF--AEIEMEEMESP----VFLEDFPQDPRTNPLARANTNNANANVAYG 1671
QRPL A + ESP + F ++ + AN NNAN N A G
Sbjct: 1744 QRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNAN-NTALG 1795
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 1984 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2043
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2044 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2103
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2104 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2134
>gi|193788720 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 1 [Homo sapiens]
Length = 2221
Score = 2289 bits (5931), Expect = 0.0
Identities = 1195/1876 (63%), Positives = 1431/1876 (76%), Gaps = 113/1876 (6%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFT--------------------SVFTVEIVLKM 851
SS +LAAEDP++ S RN IL +FDI FT S+FT+EI+LKM
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKM 972
Query: 852 TTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRA 911
T YGAFLHKGSFCRNYFN+LDLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRA
Sbjct: 973 TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRA 1032
Query: 912 KGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGY 971
KGLKHVVQC+FVAI TIGNIV+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G
Sbjct: 1033 KGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGN 1092
Query: 972 YYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDV 1031
Y YKDG+ ++ R W +S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED
Sbjct: 1093 YITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDK 1152
Query: 1032 GPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQY 1091
GPIYN RVE++IFFIIYII+IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+Y
Sbjct: 1153 GPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEY 1212
Query: 1092 ALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISD 1151
ALKARPLR YIPKN +QY+VWY+V S+YFEYLMF LI+LNTICL MQHY QS +
Sbjct: 1213 ALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMN 1272
Query: 1152 ILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASS-- 1209
ILN+ FT +FT+EMILKL+AFK +GYF DPWNVFDFLIVIGSIIDVILSE + + +
Sbjct: 1273 ILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWN 1332
Query: 1210 --GGLYCLGG---------------GCG-NVDPDESARISSAFFRLFRVMRLIKLLSRAE 1251
L +G C +++ +E++RIS FFRLFRVMRL+KLLSR E
Sbjct: 1333 TFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGE 1392
Query: 1252 GVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQ 1311
G+RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIAL D T+INRNNNFQTFPQ
Sbjct: 1393 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQ 1452
Query: 1312 AVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE--EYTCGTNFAYYYFISFYMLCA 1369
AVLLLFRCATGEAWQ+I+LAC GK C PES+ + E CG++FA +YFISFYMLCA
Sbjct: 1453 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1512
Query: 1370 FLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRI 1429
FL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IWAEYDPEAKGRIKHLDVVTLLRRI
Sbjct: 1513 FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRI 1572
Query: 1430 QPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEE 1489
QPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLFALVRTAL+IKTEGN EQANEE
Sbjct: 1573 QPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEE 1632
Query: 1490 LRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEE-YYGYRP 1548
LRAIIKKIWKRTSMKLLDQV+PP GDDEVTVGKFYATFLIQE+FRKF KR+E+ G
Sbjct: 1633 LRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPS 1692
Query: 1549 KKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAM---VEAAMEEGIFRRTGGLF 1605
+++ + +QAGLRT+ + PEI R +SGDL AEEEL++AM V AA E+ IFRR GGLF
Sbjct: 1693 QRNALSLQAGLRTL-HDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLF 1751
Query: 1606 GQVDNFLER--TNSLPPVMANQRPLQFAEIEMEEMESPVFLEDFPQDPRTNPLARANTNN 1663
G ++ + ++ P QRPL + + ++ + D P + ++T
Sbjct: 1752 GNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSST-G 1810
Query: 1664 ANANVAYGNSNHSNSHVFSSVHYEREFPEETETPATRGRALGQPCRV------LGPHSKP 1717
+NAN+ N++N+ + +P T G L RV L + +
Sbjct: 1811 SNANI-----NNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRER 1865
Query: 1718 CVEMLKGLLTQR----------AMPRGQAPPAPCQCPRVESSMPEDRKSSTPGSLHEETP 1767
V M + L +R + +A P+ C +++M ++S ++
Sbjct: 1866 HVPMCEDLELRRDSGSAGTQAHCLLLRKANPSRCHSRESQAAMAGQEETS------QDET 1919
Query: 1768 HSRSTRENTSRCSAPA 1783
+ +T CS P+
Sbjct: 1920 YEVKMNHDTEACSEPS 1935
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 2048 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2107
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2108 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2167
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2168 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2198
>gi|193788724 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 2 [Homo sapiens]
Length = 2186
Score = 2288 bits (5930), Expect = 0.0
Identities = 1181/1754 (67%), Positives = 1390/1754 (79%), Gaps = 92/1754 (5%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFT--------------------SVFTVEIVLKM 851
SS +LAAEDP++ S RN IL +FDI FT S+FT+EI+LKM
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKM 972
Query: 852 TTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRA 911
T YGAFLHKGSFCRNYFN+LDLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRA
Sbjct: 973 TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRA 1032
Query: 912 KGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGY 971
KGLKHVVQC+FVAI TIGNIV+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G
Sbjct: 1033 KGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGN 1092
Query: 972 YYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDV 1031
Y YKDG+ ++ R W +S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED
Sbjct: 1093 YITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDK 1152
Query: 1032 GPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQY 1091
GPIYN RVE++IFFIIYII+IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+Y
Sbjct: 1153 GPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEY 1212
Query: 1092 ALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISD 1151
ALKARPLR YIPKN +QY+VWY+V S+YFEYLMF LI+LNTICL MQHY QS +
Sbjct: 1213 ALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMN 1272
Query: 1152 ILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASS-- 1209
ILN+ FT +FT+EMILKL+AFK +GYF DPWNVFDFLIVIGSIIDVILSE + + +
Sbjct: 1273 ILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWN 1332
Query: 1210 --GGLYCLGG---------------GCG-NVDPDESARISSAFFRLFRVMRLIKLLSRAE 1251
L +G C +++ +E++RIS FFRLFRVMRL+KLLSR E
Sbjct: 1333 TFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGE 1392
Query: 1252 GVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQ 1311
G+RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIAL D T+INRNNNFQTFPQ
Sbjct: 1393 GIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQ 1452
Query: 1312 AVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE--EYTCGTNFAYYYFISFYMLCA 1369
AVLLLFRCATGEAWQ+I+LAC GK C PES+ + E CG++FA +YFISFYMLCA
Sbjct: 1453 AVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA 1512
Query: 1370 FLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRI 1429
FL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IWAEYDPEAKGRIKHLDVVTLLRRI
Sbjct: 1513 FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRI 1572
Query: 1430 QPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEE 1489
QPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLFALVRTAL+IKTEGN EQANEE
Sbjct: 1573 QPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEE 1632
Query: 1490 LRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEE-YYGYRP 1548
LRAIIKKIWKRTSMKLLDQV+PP GDDEVTVGKFYATFLIQE+FRKF KR+E+ G
Sbjct: 1633 LRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPS 1692
Query: 1549 KKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAM---VEAAMEEGIFRRTGGLF 1605
+++ + +QAGLRT+ + PEI R +SGDL AEEEL++AM V AA E+ IFRR GGLF
Sbjct: 1693 QRNALSLQAGLRTL-HDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLF 1751
Query: 1606 GQVDNFLER--TNSLPPVMANQRPLQF--AEIEMEEMESP----VFLEDFPQDPRTNPLA 1657
G ++ + ++ P QRPL A + ESP + F ++ +
Sbjct: 1752 GNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGS 1811
Query: 1658 RANTNNANANVAYG 1671
AN NNAN N A G
Sbjct: 1812 NANINNAN-NTALG 1824
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 2013 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2072
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2073 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2132
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2133 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2163
>gi|120433602 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 18 [Homo sapiens]
Length = 2138
Score = 2286 bits (5923), Expect = 0.0
Identities = 1168/1714 (68%), Positives = 1381/1714 (80%), Gaps = 60/1714 (3%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNML 871
SS +LAAEDP++ S RN IL +FDI FT++FT+EI LKMT YGAFLHKGSFCRNYFN+L
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL 972
Query: 872 DLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNI 931
DLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TIGNI
Sbjct: 973 DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1032
Query: 932 VLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWV 991
V+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G Y YKDG+ ++ R W
Sbjct: 1033 VIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWE 1092
Query: 992 HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIIL 1051
+S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED GPIYN RVE++IFFIIYII+
Sbjct: 1093 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 1152
Query: 1052 IAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQV 1111
IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKN +QY+V
Sbjct: 1153 IAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKV 1212
Query: 1112 WYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMA 1171
WY+V S+YFEYLMF LI+LNTICL MQHY QS +ILN+ FT +FT+EMILKL+A
Sbjct: 1213 WYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARIS 1231
FK + YF D WN FD LIV+GSI+D+ ++E++ + C +++ +E++RIS
Sbjct: 1273 FKPKHYFCDAWNTFDALIVVGSIVDIAITEVN----PAEHTQC----SPSMNAEENSRIS 1324
Query: 1232 SAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGK 1291
FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGK
Sbjct: 1325 ITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGK 1384
Query: 1292 IALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE--E 1349
IAL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LAC GK C PES+ + E
Sbjct: 1385 IALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGE 1444
Query: 1350 YTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1409
CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IWAEY
Sbjct: 1445 TPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY 1504
Query: 1410 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469
DPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1505 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFA 1564
Query: 1470 LVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLI 1529
LVRTAL+IKTEGN EQANEELRAIIKKIWKRTSMKLLDQV+PP GDDEVTVGKFYATFLI
Sbjct: 1565 LVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLI 1624
Query: 1530 QEHFRKFMKRQEE-YYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAM 1588
QE+FRKF KR+E+ G +++ + +QAGLRT+ + PEI R +SGDL AEEEL++AM
Sbjct: 1625 QEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTL-HDIGPEIRRAISGDLTAEEELDKAM 1683
Query: 1589 ---VEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMANQRPLQF--AEIEMEEMESP 1641
V AA E+ IFRR GGLFG ++ + ++ P QRPL A + ESP
Sbjct: 1684 KEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESP 1743
Query: 1642 ----VFLEDFPQDPRTNPLARANTNNANANVAYG 1671
+ F ++ + AN NNAN N A G
Sbjct: 1744 SHEKLVDSTFTPSSYSSTGSNANINNAN-NTALG 1776
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 1965 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2024
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2025 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2084
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2085 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2115
>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 4 [Homo sapiens]
Length = 2173
Score = 2283 bits (5915), Expect = 0.0
Identities = 1181/1836 (64%), Positives = 1421/1836 (77%), Gaps = 81/1836 (4%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNML 871
SS +LAAEDP++ S RN IL + D FTS+FT+EI+LKMT YGAFLHKGSFCRNYFN+L
Sbjct: 913 SSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL 972
Query: 872 DLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNI 931
DLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TIGNI
Sbjct: 973 DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1032
Query: 932 VLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWV 991
V+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G Y YKDG+ ++ R W
Sbjct: 1033 VIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWE 1092
Query: 992 HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIIL 1051
+S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED GPIYN RVE++IFFIIYII+
Sbjct: 1093 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 1152
Query: 1052 IAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQV 1111
IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKN +QY+V
Sbjct: 1153 IAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKV 1212
Query: 1112 WYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMA 1171
WY+V S+YFEYLMF LI+LNTICL MQHY QS +ILN+ FT +FT+EMILKL+A
Sbjct: 1213 WYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARIS 1231
FK + YF D WN FD LIV+GSI+D+ ++E++ + C +++ +E++RIS
Sbjct: 1273 FKPKHYFCDAWNTFDALIVVGSIVDIAITEVN----PAEHTQC----SPSMNAEENSRIS 1324
Query: 1232 SAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGK 1291
FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGK
Sbjct: 1325 ITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGK 1384
Query: 1292 IALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE--E 1349
IAL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LAC GK C PES+ + E
Sbjct: 1385 IALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGE 1444
Query: 1350 YTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1409
CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IWAEY
Sbjct: 1445 TPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY 1504
Query: 1410 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469
DPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1505 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFA 1564
Query: 1470 LVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLI 1529
LVRTAL+IKTEGN EQANEELRAIIKKIWKRTSMKLLDQV+PP GDDEVTVGKFYATFLI
Sbjct: 1565 LVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLI 1624
Query: 1530 QEHFRKFMKRQEE-YYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAM 1588
QE+FRKF KR+E+ G +++ + +QAGLRT+ + PEI R +SGDL AEEEL++AM
Sbjct: 1625 QEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTL-HDIGPEIRRAISGDLTAEEELDKAM 1683
Query: 1589 ---VEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMANQRPLQFAEIEMEEMESPVF 1643
V AA E+ IFRR GGLFG ++ + ++ P QRPL + + ++
Sbjct: 1684 KEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESP 1743
Query: 1644 LEDFPQDPRTNPLARANTNNANANVAYGNSNHSNSHVFSSVHYEREFPEETETPATRGRA 1703
+ D P + ++T +NAN+ N++N+ + +P T G
Sbjct: 1744 SHEKLVDSTFTPSSYSST-GSNANI-----NNANNTALGRLPRPAGYPSTVSTVEGHGPP 1797
Query: 1704 LGQPCRV------LGPHSKPCVEMLKGLLTQR----------AMPRGQAPPAPCQCPRVE 1747
L RV L + + V M + L +R + +A P+ C +
Sbjct: 1798 LSPAIRVQEVAWKLSSNRERHVPMCEDLELRRDSGSAGTQAHCLLLRKANPSRCHSRESQ 1857
Query: 1748 SSMPEDRKSSTPGSLHEETPHSRSTRENTSRCSAPA 1783
++M ++S ++ + +T CS P+
Sbjct: 1858 AAMAGQEETS------QDETYEVKMNHDTEACSEPS 1887
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 2000 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2059
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2060 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2119
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2120 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2150
>gi|193788542 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 17 [Homo sapiens]
Length = 2138
Score = 2282 bits (5914), Expect = 0.0
Identities = 1167/1714 (68%), Positives = 1380/1714 (80%), Gaps = 60/1714 (3%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNML 871
SS +LAAEDP++ S RN IL + D FTS+FT+EI+LKMT YGAFLHKGSFCRNYFN+L
Sbjct: 913 SSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL 972
Query: 872 DLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNI 931
DLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TIGNI
Sbjct: 973 DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1032
Query: 932 VLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWV 991
V+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G Y YKDG+ ++ R W
Sbjct: 1033 VIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWE 1092
Query: 992 HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIIL 1051
+S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED GPIYN RVE++IFFIIYII+
Sbjct: 1093 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 1152
Query: 1052 IAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQV 1111
IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKN +QY+V
Sbjct: 1153 IAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKV 1212
Query: 1112 WYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMA 1171
WY+V S+YFEYLMF LI+LNTICL MQHY QS +ILN+ FT +FT+EMILKL+A
Sbjct: 1213 WYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARIS 1231
FK + YF D WN FD LIV+GSI+D+ ++E++ + C +++ +E++RIS
Sbjct: 1273 FKPKHYFCDAWNTFDALIVVGSIVDIAITEVN----PAEHTQC----SPSMNAEENSRIS 1324
Query: 1232 SAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGK 1291
FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGK
Sbjct: 1325 ITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGK 1384
Query: 1292 IALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE--E 1349
IAL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LAC GK C PES+ + E
Sbjct: 1385 IALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGE 1444
Query: 1350 YTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1409
CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IWAEY
Sbjct: 1445 TPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY 1504
Query: 1410 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469
DPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1505 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFA 1564
Query: 1470 LVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLI 1529
LVRTAL+IKTEGN EQANEELRAIIKKIWKRTSMKLLDQV+PP GDDEVTVGKFYATFLI
Sbjct: 1565 LVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLI 1624
Query: 1530 QEHFRKFMKRQEE-YYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAM 1588
QE+FRKF KR+E+ G +++ + +QAGLRT+ + PEI R +SGDL AEEEL++AM
Sbjct: 1625 QEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTL-HDIGPEIRRAISGDLTAEEELDKAM 1683
Query: 1589 ---VEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMANQRPLQF--AEIEMEEMESP 1641
V AA E+ IFRR GGLFG ++ + ++ P QRPL A + ESP
Sbjct: 1684 KEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESP 1743
Query: 1642 ----VFLEDFPQDPRTNPLARANTNNANANVAYG 1671
+ F ++ + AN NNAN N A G
Sbjct: 1744 SHEKLVDSTFTPSSYSSTGSNANINNAN-NTALG 1776
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 1965 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2024
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2025 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2084
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2085 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2115
>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 20 [Homo sapiens]
Length = 2127
Score = 2281 bits (5912), Expect = 0.0
Identities = 1166/1714 (68%), Positives = 1376/1714 (80%), Gaps = 71/1714 (4%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNML 871
SS +LAAEDP++ S RN IL + D FTS+FT+EI+LKMT YGAFLHKGSFCRNYFN+L
Sbjct: 913 SSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL 972
Query: 872 DLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNI 931
DLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TIGNI
Sbjct: 973 DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1032
Query: 932 VLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWV 991
V+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G Y YKDG+ ++ R W
Sbjct: 1033 VIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWE 1092
Query: 992 HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIIL 1051
+S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED GPIYN RVE++IFFIIYII+
Sbjct: 1093 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 1152
Query: 1052 IAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQV 1111
IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKN +QY+V
Sbjct: 1153 IAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKV 1212
Query: 1112 WYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMA 1171
WY+V S+YFEYLMF LI+LNTICL MQHY QS +ILN+ FT +FT+EMILKL+A
Sbjct: 1213 WYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARIS 1231
FK + YF D WN FD LIV+GSI+D+ ++E++ + +E++RIS
Sbjct: 1273 FKPKHYFCDAWNTFDALIVVGSIVDIAITEVN-------------------NAEENSRIS 1313
Query: 1232 SAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGK 1291
FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGK
Sbjct: 1314 ITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGK 1373
Query: 1292 IALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE--E 1349
IAL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LAC GK C PES+ + E
Sbjct: 1374 IALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGE 1433
Query: 1350 YTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1409
CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IWAEY
Sbjct: 1434 TPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY 1493
Query: 1410 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469
DPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1494 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFA 1553
Query: 1470 LVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLI 1529
LVRTAL+IKTEGN EQANEELRAIIKKIWKRTSMKLLDQV+PP GDDEVTVGKFYATFLI
Sbjct: 1554 LVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLI 1613
Query: 1530 QEHFRKFMKRQEE-YYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAM 1588
QE+FRKF KR+E+ G +++ + +QAGLRT+ + PEI R +SGDL AEEEL++AM
Sbjct: 1614 QEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTL-HDIGPEIRRAISGDLTAEEELDKAM 1672
Query: 1589 ---VEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMANQRPLQF--AEIEMEEMESP 1641
V AA E+ IFRR GGLFG ++ + ++ P QRPL A + ESP
Sbjct: 1673 KEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESP 1732
Query: 1642 ----VFLEDFPQDPRTNPLARANTNNANANVAYG 1671
+ F ++ + AN NNAN N A G
Sbjct: 1733 SHEKLVDSTFTPSSYSSTGSNANINNAN-NTALG 1765
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 1954 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2013
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2014 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2073
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2074 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2104
>gi|193788526 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 6 [Homo sapiens]
Length = 2158
Score = 2275 bits (5896), Expect = 0.0
Identities = 1169/1734 (67%), Positives = 1382/1734 (79%), Gaps = 80/1734 (4%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFT--------------------SVFTVEIVLKM 851
SS +LAAEDP++ S RN IL +FDI FT S+FT+EI+LKM
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKM 972
Query: 852 TTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRA 911
T YGAFLHKGSFCRNYFN+LDLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRA
Sbjct: 973 TAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRA 1032
Query: 912 KGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGY 971
KGLKHVVQC+FVAI TIGNIV+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G
Sbjct: 1033 KGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGN 1092
Query: 972 YYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDV 1031
Y YKDG+ ++ R W +S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED
Sbjct: 1093 YITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDK 1152
Query: 1032 GPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQY 1091
GPIYN RVE++IFFIIYII+IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+Y
Sbjct: 1153 GPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEY 1212
Query: 1092 ALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISD 1151
ALKARPLR YIPKN +QY+VWY+V S+YFEYLMF LI+LNTICL MQHY QS +
Sbjct: 1213 ALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMN 1272
Query: 1152 ILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGG 1211
ILN+ FT +FT+EMILKL+AFK + YF D WN FD LIV+GSI+D+ ++E++ +
Sbjct: 1273 ILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVN----PAEH 1328
Query: 1212 LYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVA 1271
C +++ +E++RIS FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVA
Sbjct: 1329 TQC----SPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVA 1384
Query: 1272 LLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLA 1331
LLIVMLFFIYAVIGMQ+FGKIAL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LA
Sbjct: 1385 LLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLA 1444
Query: 1332 CSYGKLCDPESDYAPGE--EYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTR 1389
C GK C PES+ + E CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTR
Sbjct: 1445 CMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTR 1504
Query: 1390 DWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLV 1449
DWSILGPHHLDEFK IWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV
Sbjct: 1505 DWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV 1564
Query: 1450 GMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQV 1509
MNMPLNSDGTV FNATLFALVRTAL+IKTEGN EQANEELRAIIKKIWKRTSMKLLDQV
Sbjct: 1565 SMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQV 1624
Query: 1510 IPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEE-YYGYRPKKDIVQIQAGLRTIEEEAAP 1568
+PP GDDEVTVGKFYATFLIQE+FRKF KR+E+ G +++ + +QAGLRT+ + P
Sbjct: 1625 VPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTL-HDIGP 1683
Query: 1569 EICRTVSGDLAAEEELERAM---VEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMA 1623
EI R +SGDL AEEEL++AM V AA E+ IFRR GGLFG ++ + ++ P
Sbjct: 1684 EIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFT 1743
Query: 1624 NQRPLQF--AEIEMEEMESP----VFLEDFPQDPRTNPLARANTNNANANVAYG 1671
QRPL A + ESP + F ++ + AN NNAN N A G
Sbjct: 1744 TQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNAN-NTALG 1796
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 1985 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2044
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2045 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2104
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2105 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2135
>gi|193788528 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 8 [Homo sapiens]
Length = 2157
Score = 2274 bits (5893), Expect = 0.0
Identities = 1168/1733 (67%), Positives = 1381/1733 (79%), Gaps = 79/1733 (4%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNML 871
SS +LAAEDP++ S RN IL +FDI FT++FT+EI LKMT YGAFLHKGSFCRNYFN+L
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL 972
Query: 872 DLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNI 931
DLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TIGNI
Sbjct: 973 DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1032
Query: 932 VLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWV 991
V+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G Y YKDG+ ++ R W
Sbjct: 1033 VIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWE 1092
Query: 992 HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIIL 1051
+S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED GPIYN RVE++IFFIIYII+
Sbjct: 1093 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 1152
Query: 1052 IAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQV 1111
IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKN +QY+V
Sbjct: 1153 IAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKV 1212
Query: 1112 WYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMA 1171
WY+V S+YFEYLMF LI+LNTICL MQHY QS +ILN+ FT +FT+EMILKL+A
Sbjct: 1213 WYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARIS 1231
FK + YF D WN FD LIV+GSI+D+ ++E++ + C +++ +E++RIS
Sbjct: 1273 FKPKHYFCDAWNTFDALIVVGSIVDIAITEVN----PAEHTQC----SPSMNAEENSRIS 1324
Query: 1232 SAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGK 1291
FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGK
Sbjct: 1325 ITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGK 1384
Query: 1292 IALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE--E 1349
IAL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LAC GK C PES+ + E
Sbjct: 1385 IALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGE 1444
Query: 1350 YTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1409
CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IWAEY
Sbjct: 1445 TPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY 1504
Query: 1410 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469
DPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1505 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFA 1564
Query: 1470 LVRTALKIKTE-------------------GNFEQANEELRAIIKKIWKRTSMKLLDQVI 1510
LVRTAL+IKTE GN EQANEELRAIIKKIWKRTSMKLLDQV+
Sbjct: 1565 LVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVV 1624
Query: 1511 PPIGDDEVTVGKFYATFLIQEHFRKFMKRQEE-YYGYRPKKDIVQIQAGLRTIEEEAAPE 1569
PP GDDEVTVGKFYATFLIQE+FRKF KR+E+ G +++ + +QAGLRT+ + PE
Sbjct: 1625 PPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTL-HDIGPE 1683
Query: 1570 ICRTVSGDLAAEEELERAM---VEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMAN 1624
I R +SGDL AEEEL++AM V AA E+ IFRR GGLFG ++ + ++ P
Sbjct: 1684 IRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTT 1743
Query: 1625 QRPLQF--AEIEMEEMESP----VFLEDFPQDPRTNPLARANTNNANANVAYG 1671
QRPL A + ESP + F ++ + AN NNAN N A G
Sbjct: 1744 QRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNAN-NTALG 1795
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 1984 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2043
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2044 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2103
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2104 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2134
>gi|193788532 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 11 [Homo sapiens]
Length = 2146
Score = 2273 bits (5891), Expect = 0.0
Identities = 1167/1733 (67%), Positives = 1377/1733 (79%), Gaps = 90/1733 (5%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNML 871
SS +LAAEDP++ S RN IL +FDI FT++FT+EI LKMT YGAFLHKGSFCRNYFN+L
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL 972
Query: 872 DLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNI 931
DLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TIGNI
Sbjct: 973 DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1032
Query: 932 VLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWV 991
V+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G Y YKDG+ ++ R W
Sbjct: 1033 VIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWE 1092
Query: 992 HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIIL 1051
+S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED GPIYN RVE++IFFIIYII+
Sbjct: 1093 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 1152
Query: 1052 IAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQV 1111
IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKN +QY+V
Sbjct: 1153 IAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKV 1212
Query: 1112 WYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMA 1171
WY+V S+YFEYLMF LI+LNTICL MQHY QS +ILN+ FT +FT+EMILKL+A
Sbjct: 1213 WYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARIS 1231
FK + YF D WN FD LIV+GSI+D+ ++E++ + +E++RIS
Sbjct: 1273 FKPKHYFCDAWNTFDALIVVGSIVDIAITEVN-------------------NAEENSRIS 1313
Query: 1232 SAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGK 1291
FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGK
Sbjct: 1314 ITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGK 1373
Query: 1292 IALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE--E 1349
IAL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LAC GK C PES+ + E
Sbjct: 1374 IALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGE 1433
Query: 1350 YTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1409
CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IWAEY
Sbjct: 1434 TPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY 1493
Query: 1410 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469
DPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1494 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFA 1553
Query: 1470 LVRTALKIKTE-------------------GNFEQANEELRAIIKKIWKRTSMKLLDQVI 1510
LVRTAL+IKTE GN EQANEELRAIIKKIWKRTSMKLLDQV+
Sbjct: 1554 LVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVV 1613
Query: 1511 PPIGDDEVTVGKFYATFLIQEHFRKFMKRQEE-YYGYRPKKDIVQIQAGLRTIEEEAAPE 1569
PP GDDEVTVGKFYATFLIQE+FRKF KR+E+ G +++ + +QAGLRT+ + PE
Sbjct: 1614 PPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTL-HDIGPE 1672
Query: 1570 ICRTVSGDLAAEEELERAM---VEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMAN 1624
I R +SGDL AEEEL++AM V AA E+ IFRR GGLFG ++ + ++ P
Sbjct: 1673 IRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTT 1732
Query: 1625 QRPLQF--AEIEMEEMESP----VFLEDFPQDPRTNPLARANTNNANANVAYG 1671
QRPL A + ESP + F ++ + AN NNAN N A G
Sbjct: 1733 QRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNAN-NTALG 1784
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 1973 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2032
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2033 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2092
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2093 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2123
>gi|193788728 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 3 [Homo sapiens]
Length = 2179
Score = 2273 bits (5890), Expect = 0.0
Identities = 1173/1749 (67%), Positives = 1384/1749 (79%), Gaps = 89/1749 (5%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNML 871
SS +LAAEDP++ S RN IL +FDI FT++FT+EI LKMT YGAFLHKGSFCRNYFN+L
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL 972
Query: 872 DLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNI 931
DLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TIGNI
Sbjct: 973 DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1032
Query: 932 VLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWV 991
V+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G Y YKDG+ ++ R W
Sbjct: 1033 VIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWE 1092
Query: 992 HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIIL 1051
+S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED GPIYN RVE++IFFIIYII+
Sbjct: 1093 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 1152
Query: 1052 IAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQV 1111
IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKN +QY+V
Sbjct: 1153 IAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKV 1212
Query: 1112 WYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMA 1171
WY+V S+YFEYLMF LI+LNTICL MQHY QS +ILN+ FT +FT+EMILKL+A
Sbjct: 1213 WYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEID----TFLASSGGLYC------------L 1215
FK + YF D WN FD LIV+GSI+D+ ++E++ T + S G C +
Sbjct: 1273 FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMGPSCSHPPLAVLTAPPV 1332
Query: 1216 GGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIV 1275
G N +E++RIS FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLIV
Sbjct: 1333 ADGFQNA--EENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIV 1390
Query: 1276 MLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYG 1335
MLFFIYAVIGMQ+FGKIAL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LAC G
Sbjct: 1391 MLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPG 1450
Query: 1336 KLCDPESDYAPGE--EYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSI 1393
K C PES+ + E CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSI
Sbjct: 1451 KKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSI 1510
Query: 1394 LGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNM 1453
LGPHHLDEFK IWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNM
Sbjct: 1511 LGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNM 1570
Query: 1454 PLNSDGTVTFNATLFALVRTALKIKTE-------------------GNFEQANEELRAII 1494
PLNSDGTV FNATLFALVRTAL+IKTE GN EQANEELRAII
Sbjct: 1571 PLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAII 1630
Query: 1495 KKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEE-YYGYRPKKDIV 1553
KKIWKRTSMKLLDQV+PP GDDEVTVGKFYATFLIQE+FRKF KR+E+ G +++ +
Sbjct: 1631 KKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNAL 1690
Query: 1554 QIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAM---VEAAMEEGIFRRTGGLFGQVDN 1610
+QAGLRT+ + PEI R +SGDL AEEEL++AM V AA E+ IFRR GGLFG +
Sbjct: 1691 SLQAGLRTL-HDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVS 1749
Query: 1611 FLER--TNSLPPVMANQRPLQF--AEIEMEEMESP----VFLEDFPQDPRTNPLARANTN 1662
+ + ++ P QRPL A + ESP + F ++ + AN N
Sbjct: 1750 YYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANIN 1809
Query: 1663 NANANVAYG 1671
NAN N A G
Sbjct: 1810 NAN-NTALG 1817
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 2006 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2065
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2066 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2125
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2126 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2156
>gi|193794832 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoforom 13 [Homo sapiens]
Length = 2144
Score = 2271 bits (5885), Expect = 0.0
Identities = 1167/1733 (67%), Positives = 1375/1733 (79%), Gaps = 92/1733 (5%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNML 871
SS +LAAEDP++ S RN IL +FDI FT++FT+EI LKMT YGAFLHKGSFCRNYFN+L
Sbjct: 913 SSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL 972
Query: 872 DLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNI 931
DLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TIGNI
Sbjct: 973 DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1032
Query: 932 VLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWV 991
V+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G Y YKDG+ ++ R W
Sbjct: 1033 VIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWE 1092
Query: 992 HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIIL 1051
+S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED GPIYN RVE++IFFIIYII+
Sbjct: 1093 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 1152
Query: 1052 IAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQV 1111
IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKN +QY+V
Sbjct: 1153 IAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKV 1212
Query: 1112 WYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMA 1171
WY+V S+YFEYLMF LI+LNTICL MQHY QS +ILN+ FT +FT+EMILKL+A
Sbjct: 1213 WYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARIS 1231
FK + YF D WN FD LIV+GSI+D+ ++E + +E++RIS
Sbjct: 1273 FKPKHYFCDAWNTFDALIVVGSIVDIAITE---------------------NAEENSRIS 1311
Query: 1232 SAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGK 1291
FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGK
Sbjct: 1312 ITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGK 1371
Query: 1292 IALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE--E 1349
IAL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LAC GK C PES+ + E
Sbjct: 1372 IALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGE 1431
Query: 1350 YTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1409
CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IWAEY
Sbjct: 1432 TPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY 1491
Query: 1410 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469
DPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1492 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFA 1551
Query: 1470 LVRTALKIKTE-------------------GNFEQANEELRAIIKKIWKRTSMKLLDQVI 1510
LVRTAL+IKTE GN EQANEELRAIIKKIWKRTSMKLLDQV+
Sbjct: 1552 LVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVV 1611
Query: 1511 PPIGDDEVTVGKFYATFLIQEHFRKFMKRQEE-YYGYRPKKDIVQIQAGLRTIEEEAAPE 1569
PP GDDEVTVGKFYATFLIQE+FRKF KR+E+ G +++ + +QAGLRT+ + PE
Sbjct: 1612 PPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTL-HDIGPE 1670
Query: 1570 ICRTVSGDLAAEEELERAM---VEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMAN 1624
I R +SGDL AEEEL++AM V AA E+ IFRR GGLFG ++ + ++ P
Sbjct: 1671 IRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTT 1730
Query: 1625 QRPLQF--AEIEMEEMESP----VFLEDFPQDPRTNPLARANTNNANANVAYG 1671
QRPL A + ESP + F ++ + AN NNAN N A G
Sbjct: 1731 QRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNAN-NTALG 1782
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 1971 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2030
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2031 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2090
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2091 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2121
>gi|193788530 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 9 [Homo sapiens]
Length = 2157
Score = 2271 bits (5884), Expect = 0.0
Identities = 1167/1733 (67%), Positives = 1380/1733 (79%), Gaps = 79/1733 (4%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNML 871
SS +LAAEDP++ S RN IL + D FTS+FT+EI+LKMT YGAFLHKGSFCRNYFN+L
Sbjct: 913 SSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL 972
Query: 872 DLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNI 931
DLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TIGNI
Sbjct: 973 DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1032
Query: 932 VLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWV 991
V+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G Y YKDG+ ++ R W
Sbjct: 1033 VIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWE 1092
Query: 992 HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIIL 1051
+S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED GPIYN RVE++IFFIIYII+
Sbjct: 1093 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 1152
Query: 1052 IAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQV 1111
IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKN +QY+V
Sbjct: 1153 IAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKV 1212
Query: 1112 WYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMA 1171
WY+V S+YFEYLMF LI+LNTICL MQHY QS +ILN+ FT +FT+EMILKL+A
Sbjct: 1213 WYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARIS 1231
FK + YF D WN FD LIV+GSI+D+ ++E++ + C +++ +E++RIS
Sbjct: 1273 FKPKHYFCDAWNTFDALIVVGSIVDIAITEVN----PAEHTQC----SPSMNAEENSRIS 1324
Query: 1232 SAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGK 1291
FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGK
Sbjct: 1325 ITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGK 1384
Query: 1292 IALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE--E 1349
IAL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LAC GK C PES+ + E
Sbjct: 1385 IALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGE 1444
Query: 1350 YTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1409
CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IWAEY
Sbjct: 1445 TPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY 1504
Query: 1410 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469
DPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1505 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFA 1564
Query: 1470 LVRTALKIKTE-------------------GNFEQANEELRAIIKKIWKRTSMKLLDQVI 1510
LVRTAL+IKTE GN EQANEELRAIIKKIWKRTSMKLLDQV+
Sbjct: 1565 LVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVV 1624
Query: 1511 PPIGDDEVTVGKFYATFLIQEHFRKFMKRQEE-YYGYRPKKDIVQIQAGLRTIEEEAAPE 1569
PP GDDEVTVGKFYATFLIQE+FRKF KR+E+ G +++ + +QAGLRT+ + PE
Sbjct: 1625 PPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTL-HDIGPE 1683
Query: 1570 ICRTVSGDLAAEEELERAM---VEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMAN 1624
I R +SGDL AEEEL++AM V AA E+ IFRR GGLFG ++ + ++ P
Sbjct: 1684 IRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTT 1743
Query: 1625 QRPLQF--AEIEMEEMESP----VFLEDFPQDPRTNPLARANTNNANANVAYG 1671
QRPL A + ESP + F ++ + AN NNAN N A G
Sbjct: 1744 QRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNAN-NTALG 1795
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 1984 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2043
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2044 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2103
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2104 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2134
>gi|193788536 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 14 [Homo sapiens]
Length = 2138
Score = 2270 bits (5883), Expect = 0.0
Identities = 1162/1714 (67%), Positives = 1377/1714 (80%), Gaps = 60/1714 (3%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYW+
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWM 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
DA+G E PW+YFV+L++ GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 QDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNML 871
SS +LAAEDP++ S RN IL + D FTS+FT+EI+LKMT YGAFLHKGSFCRNYFN+L
Sbjct: 913 SSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL 972
Query: 872 DLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNI 931
DLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TIGNI
Sbjct: 973 DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1032
Query: 932 VLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWV 991
V+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G Y YKDG+ ++ R W
Sbjct: 1033 VIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWE 1092
Query: 992 HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIIL 1051
+S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED GPIYN RVE++IFFIIYII+
Sbjct: 1093 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 1152
Query: 1052 IAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQV 1111
IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKN +QY+V
Sbjct: 1153 IAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKV 1212
Query: 1112 WYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMA 1171
WY+V S+YFEYLMF LI+LNTICL MQHY QS +ILN+ FT +FT+EMILKL+A
Sbjct: 1213 WYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARIS 1231
FK + YF D WN FD LIV+GSI+D+ ++E++ + C +++ +E++RIS
Sbjct: 1273 FKPKHYFCDAWNTFDALIVVGSIVDIAITEVN----PAEHTQC----SPSMNAEENSRIS 1324
Query: 1232 SAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGK 1291
FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGK
Sbjct: 1325 ITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGK 1384
Query: 1292 IALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE--E 1349
IAL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LAC GK C PES+ + E
Sbjct: 1385 IALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGE 1444
Query: 1350 YTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1409
CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IWAEY
Sbjct: 1445 TPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY 1504
Query: 1410 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469
DPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1505 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFA 1564
Query: 1470 LVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLI 1529
LVRTAL+IKTEGN EQANEELRAIIKKIWKRTSMKLLDQV+PP GDDEVTVGKFYATFLI
Sbjct: 1565 LVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLI 1624
Query: 1530 QEHFRKFMKRQEE-YYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAM 1588
QE+FRKF KR+E+ G +++ + +QAGLRT+ + PEI R +SGDL AEEEL++AM
Sbjct: 1625 QEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTL-HDIGPEIRRAISGDLTAEEELDKAM 1683
Query: 1589 ---VEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMANQRPLQF--AEIEMEEMESP 1641
V AA E+ IFRR GGLFG ++ + ++ P QRPL A + ESP
Sbjct: 1684 KEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESP 1743
Query: 1642 ----VFLEDFPQDPRTNPLARANTNNANANVAYG 1671
+ F ++ + AN NNAN N A G
Sbjct: 1744 SHEKLVDSTFTPSSYSSTGSNANINNAN-NTALG 1776
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 1965 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2024
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2025 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2084
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2085 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2115
>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 12 [Homo sapiens]
Length = 2146
Score = 2270 bits (5882), Expect = 0.0
Identities = 1166/1733 (67%), Positives = 1376/1733 (79%), Gaps = 90/1733 (5%)
Query: 4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFA 63
SS Q + + +PKK RPPRAL CLTL+NP+R+ACISIVEWKPFE IILLTIFA
Sbjct: 77 SSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFA 136
Query: 64 NCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWN 123
NCVALA+Y+P PEDD+N+ N LE++EY FLI+F++EA +K+IAYG LFH +AYLR+GWN
Sbjct: 137 NCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWN 196
Query: 124 VLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQ 183
+LDF IV +G+F+ ILEQ A + KGAG DVKALRAFRVLRPLRLVSGVPSLQ
Sbjct: 197 LLDFIIVVVGLFSAILEQATKADGANA-LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQ 255
Query: 184 VVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEE-P 242
VVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTCY + +A V E+ P
Sbjct: 256 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY--NQEGIADVPAEDDP 313
Query: 243 SPCA-RTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV 301
SPCA TG GR+C NG+ C+ GW GP HGIT+FDNF F+MLTV+QCITMEGWTDVLYWV
Sbjct: 314 SPCALETGHGRQCQ-NGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV 372
Query: 302 NDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE 361
NDA+G +WPWIYFVTLI++GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKLREKQQL+E
Sbjct: 373 NDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE 432
Query: 362 DLRGYMSWITQGEVMDVEDFREGK-----LSLDEGGSDTESLY-------EIAGLN---- 405
DL+GY+ WITQ E +D E+ EG ++ S+TES+ +I G N
Sbjct: 433 DLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGAR 492
Query: 406 -----KIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWL 460
+F R+WR+WNR R KC VKS VFYWLVI +V LNTL+IASEH+NQP WL
Sbjct: 493 LAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWL 552
Query: 461 TRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT 520
T +QD AN+ LL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GILE +LVE+ M+
Sbjct: 553 TEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMS 612
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
PLGISVLRC+RLLRIFKIT+YW SLSNLVASLLNS+RSIASLLLLLFLFI+IF+LLGMQL
Sbjct: 613 PLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQL 672
Query: 581 FGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIY 640
FGG+++F++ + RRS FDNFPQ+L++VFQ+LTGEDW S+MY+GIMAYGGPS+PGMLVCIY
Sbjct: 673 FGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIY 732
Query: 641 FIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSK-GLPDKSEE--E 697
FIILF+CGNYILLNVFLAIAVDNLA+AESLTSAQK + EEK+R+K+++ P+K +E E
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVE 792
Query: 698 KSTMAKKLEQKPKGEGI------PTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPE 751
K + + E+K + + I P K+ +D+ + N NE K PYP+ + G+++E+EPE
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPE 852
Query: 752 IPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILL 811
+P+ PRPRPL+EL LKEKAVP+PEAS+FFIFS N+ R+ CHRIVN T FTN IL FILL
Sbjct: 853 MPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILL 912
Query: 812 SSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNML 871
SS +LAAEDP++ S RN IL + D FTS+FT+EI+LKMT YGAFLHKGSFCRNYFN+L
Sbjct: 913 SSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNIL 972
Query: 872 DLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNI 931
DLLVV+VSLIS G++SSAI+VVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TIGNI
Sbjct: 973 DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1032
Query: 932 VLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWV 991
V+VTTLLQFMFACIGVQLFKGK + C+D SK TE EC+G Y YKDG+ ++ R W
Sbjct: 1033 VIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWE 1092
Query: 992 HSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIIL 1051
+S F FDNVL+AMM+LFTVSTFEGWP+LLY++IDS+ ED GPIYN RVE++IFFIIYII+
Sbjct: 1093 NSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIII 1152
Query: 1052 IAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQV 1111
IAFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKN +QY+V
Sbjct: 1153 IAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKV 1212
Query: 1112 WYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMA 1171
WY+V S+YFEYLMF LI+LNTICL MQHY QS +ILN+ FT +FT+EMILKL+A
Sbjct: 1213 WYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 1172 FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARIS 1231
FK + YF D WN FD LIV+GSI+D+ ++E++ + +E++RIS
Sbjct: 1273 FKPKHYFCDAWNTFDALIVVGSIVDIAITEVN-------------------NAEENSRIS 1313
Query: 1232 SAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGK 1291
FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGK
Sbjct: 1314 ITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGK 1373
Query: 1292 IALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE--E 1349
IAL D T+INRNNNFQTFPQAVLLLFRCATGEAWQ+I+LAC GK C PES+ + E
Sbjct: 1374 IALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGE 1433
Query: 1350 YTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEY 1409
CG++FA +YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IWAEY
Sbjct: 1434 TPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEY 1493
Query: 1410 DPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469
DPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLFA
Sbjct: 1494 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFA 1553
Query: 1470 LVRTALKIKTE-------------------GNFEQANEELRAIIKKIWKRTSMKLLDQVI 1510
LVRTAL+IKTE GN EQANEELRAIIKKIWKRTSMKLLDQV+
Sbjct: 1554 LVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVV 1613
Query: 1511 PPIGDDEVTVGKFYATFLIQEHFRKFMKRQEE-YYGYRPKKDIVQIQAGLRTIEEEAAPE 1569
PP GDDEVTVGKFYATFLIQE+FRKF KR+E+ G +++ + +QAGLRT+ + PE
Sbjct: 1614 PPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTL-HDIGPE 1672
Query: 1570 ICRTVSGDLAAEEELERAM---VEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMAN 1624
I R +SGDL AEEEL++AM V AA E+ IFRR GGLFG ++ + ++ P
Sbjct: 1673 IRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTT 1732
Query: 1625 QRPLQF--AEIEMEEMESP----VFLEDFPQDPRTNPLARANTNNANANVAYG 1671
QRPL A + ESP + F ++ + AN NNAN N A G
Sbjct: 1733 QRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNAN-NTALG 1784
Score = 49.7 bits (117), Expect = 3e-05
Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 24/151 (15%)
Query: 1737 PPAPCQCPRVESSMPEDRKSSTPGSLH-----EETPH------SRSTRENT----SRCSA 1781
PP P R+E ++ +S+ S+H E TP +R R + S+ A
Sbjct: 1973 PPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGA 2032
Query: 1782 P------ATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEPEEVEIMATELLKG 1835
P + + L++ L+ GLG A D FI T Q LADAC M EE+E A +L G
Sbjct: 2033 PGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSG 2092
Query: 1836 --REAPEG-MASSLGCLNLGSSLGSLDQHQG 1863
++P G + + C + G ++ G
Sbjct: 2093 GAPQSPNGALLPFVNCRDAGQDRAGGEEDAG 2123
>gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform a [Homo sapiens]
Length = 2181
Score = 2269 bits (5879), Expect = 0.0
Identities = 1172/1784 (65%), Positives = 1377/1784 (77%), Gaps = 111/1784 (6%)
Query: 1 MEPSSPQDEGL---RKKQP----KKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPF 53
M S+P G RK+Q KK RP RALFCL+L NP+R+ACISIVEWKPF
Sbjct: 69 MSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPF 128
Query: 54 ETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFH 113
+ ILL IFANCVALA+Y+P PEDD+NS N LEK+EY FLI+F++E +KIIAYG L H
Sbjct: 129 DIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLH 188
Query: 114 QDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPL 173
+AY+R+GWN+LDF IV +G+F+VILEQ+ S K G DVKALRAFRVLRPL
Sbjct: 189 PNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPL 248
Query: 174 RLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDI 233
RLVSGVPSLQVVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTC+F +DI
Sbjct: 249 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDI 308
Query: 234 VATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEG 293
VA E+P+PCA +G+GR+CT NG+ECR GW GPN GIT+FDNF F+MLTV+QCITMEG
Sbjct: 309 VA---EEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 365
Query: 294 WTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKL 353
WTDVLYWVNDAIG EWPW+YFV+LI+LGSFF+LNLVLGVLSGEF+KEREKAK+RG FQKL
Sbjct: 366 WTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 425
Query: 354 REKQQLDEDLRGYMSWITQGEVMDVEDFREG----KLSLDEGGSDTESLYEI-------- 401
REKQQL+EDL+GY+ WITQ E +D E+ EG K + S+TES+
Sbjct: 426 REKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGEN 485
Query: 402 ---------------------AGLNKIIQFI------RHWRQWNRIFRWKCHDIVKSKVF 434
+G + Q I R WR+WNR R +C VKS F
Sbjct: 486 RGCCGSLWCWWRRRGAAKAGPSGCRRWGQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTF 545
Query: 435 YWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMS 494
YWLVI++V LNTL+I+SEH+NQP WLT++QDIAN+VLL+LFT EML+KMY LGL+ YF+S
Sbjct: 546 YWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVS 605
Query: 495 IFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLN 554
+FNRFDCFVVC GI E +LVE M+PLGISV RC+RLLRIFK+T++WTSLSNLVASLLN
Sbjct: 606 LFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLN 665
Query: 555 SIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGE 614
S++SIASLLLLLFLFI+IF+LLGMQLFGG+++F++T+ +RS FDNFPQAL++VFQ+LTGE
Sbjct: 666 SMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGE 725
Query: 615 DWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQ 674
DW ++MY+GIMAYGGPS GM+VCIYFIILF+CGNYILLNVFLAIAVDNLA+AESL +AQ
Sbjct: 726 DWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQ 785
Query: 675 KAKAEEKKRRKMSKGLPDKSEEEKSTMAKKLEQKPKGEGIPTTA-KLKIDEFESNVNEVK 733
K +AEEK+R+K+++ K ++ K KP+ I + K+ ID++ +E K
Sbjct: 786 KEEAEEKERKKIAR---------KESLENKKNNKPEVNQIANSDNKVTIDDYREE-DEDK 835
Query: 734 DPYPSADFP-----GDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKI 788
DPYP D P ++EEDEPE+P PRPR ++EL +KEK PIPE S+FFI S TN I
Sbjct: 836 DPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPI 895
Query: 789 RVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIV 848
RV CH+++N FTN IL+FI+LSSAALAAEDPIR+ S RN IL +FD FT++FTVEI+
Sbjct: 896 RVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEIL 955
Query: 849 LKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAI 908
LKMTT+GAFLHKG+FCRNYFN+LD+LVV VSL+S G++SSAISVVKILRVLRVLRPLRAI
Sbjct: 956 LKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAI 1015
Query: 909 NRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEEC 968
NRAKGLKHVVQC+FVAI TIGNI++VTTLLQFMFACIGVQLFKGKF+RCTD +K EEC
Sbjct: 1016 NRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEEC 1075
Query: 969 RGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNA 1028
RG + +YKDGD +R R W +SDF+FDNVLSAMM+LFTVSTFEGWP LLYKAIDSN
Sbjct: 1076 RGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNG 1135
Query: 1029 EDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQC 1088
E++GPIYN+RVE++IFFIIYII++AFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQC
Sbjct: 1136 ENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQC 1195
Query: 1089 VQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNH 1148
V+YALKARPLR YIPKNPYQY+ WY+V SS FEY+MF LIMLNT+CL MQHY QS+ N
Sbjct: 1196 VEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFND 1255
Query: 1149 ISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLAS 1208
DILN+ FT +FT+EM+LK++AFK +GYF D WN FD LIVIGSIIDV LSE D +
Sbjct: 1256 AMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESE 1315
Query: 1209 SGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALP 1268
+ + G + +ES RIS FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALP
Sbjct: 1316 NVPVPTATPG----NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALP 1371
Query: 1269 YVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEI 1328
YVALLI MLFFIYAVIGMQMFGK+A+ D QINRNNNFQTFPQAVLLLFRCATGEAWQEI
Sbjct: 1372 YVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEI 1431
Query: 1329 LLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLT 1388
+LAC GKLCDPESDY PGEEYTCG+NFA YFISFYMLCAFL+INLFVAVIMDNFDYLT
Sbjct: 1432 MLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLT 1491
Query: 1389 RDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRL 1448
RDWSILGPHHLDEFK IW+EYDPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRL
Sbjct: 1492 RDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRL 1551
Query: 1449 VGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQ 1508
V MNMPLNSDGTV FNATLFALVRTALKIKTEGN EQANEELRA+IKKIWK+TSMKLLDQ
Sbjct: 1552 VAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQ 1611
Query: 1509 VIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEE--YYGYRPKKDIVQIQAGLRTIEEEA 1566
V+PP GDDEVTVGKFYATFLIQ++FRKF KR+E+ Y K + +QAGLRT+ +
Sbjct: 1612 VVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTL-HDI 1670
Query: 1567 APEICRTVSGDLAAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFL--ERTNSLPPVMAN 1624
PEI R +S DL +E E E E+ +F+R G L G N + +R +SL
Sbjct: 1671 GPEIRRAISCDLQDDEPEETKREE---EDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTT 1727
Query: 1625 QRPLQFAEIEM---EEMESPVFLEDFPQDPRTNPL-----------------ARANTNNA 1664
RPL + + E P+F P N + AN NNA
Sbjct: 1728 HRPLHVQRPSIPPASDTEKPLF------PPAGNSVCHNHHNHNSIGKQVPTSTNANLNNA 1781
Query: 1665 NANVA-------YGNSNHSNSHVFSSVH-YEREFPEETETPATR 1700
N + A GN H + + S H ++RE + TR
Sbjct: 1782 NMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRTR 1825
Score = 47.0 bits (110), Expect = 2e-04
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 5/85 (5%)
Query: 1755 KSSTPGSLHEETPHSRSTRENTSRCSAPATALLIQKALVRGGLGTLAADANFIMATGQAL 1814
++ TP SL P S + + + SA + L++ L+ GLG A D F+ AT +
Sbjct: 2054 RTFTPASL--TVPSSFRNKNSDKQRSADS---LVEAVLISEGLGRYARDPKFVSATKHEI 2108
Query: 1815 ADACQMEPEEVEIMATELLKGREAP 1839
ADAC + +E+E A+ LL G P
Sbjct: 2109 ADACDLTIDEMESAASTLLNGNVRP 2133
>gi|192807300 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform b [Homo sapiens]
Length = 2161
Score = 2268 bits (5878), Expect = 0.0
Identities = 1167/1764 (66%), Positives = 1376/1764 (78%), Gaps = 91/1764 (5%)
Query: 1 MEPSSPQDEGL---RKKQP----KKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPF 53
M S+P G RK+Q KK RP RALFCL+L NP+R+ACISIVEWKPF
Sbjct: 69 MSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPF 128
Query: 54 ETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFH 113
+ ILL IFANCVALA+Y+P PEDD+NS N LEK+EY FLI+F++E +KIIAYG L H
Sbjct: 129 DIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLH 188
Query: 114 QDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPL 173
+AY+R+GWN+LDF IV +G+F+VILEQ+ S K G DVKALRAFRVLRPL
Sbjct: 189 PNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPL 248
Query: 174 RLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDI 233
RLVSGVPSLQVVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTC+F +DI
Sbjct: 249 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDI 308
Query: 234 VATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEG 293
VA E+P+PCA +G+GR+CT NG+ECR GW GPN GIT+FDNF F+MLTV+QCITMEG
Sbjct: 309 VA---EEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 365
Query: 294 WTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKL 353
WTDVLYW+NDA+G E PW+YFV+L++ GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKL
Sbjct: 366 WTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 425
Query: 354 REKQQLDEDLRGYMSWITQGEVMDVEDFREG----KLSLDEGGSDTESLY--EIAG---- 403
REKQQL+EDL+GY+ WITQ E +D E+ EG K + S+TES+ ++G
Sbjct: 426 REKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGEN 485
Query: 404 ---LNKIIQFI------RHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHH 454
+ Q I R WR+WNR R +C VKS FYWLVI++V LNTL+I+SEH+
Sbjct: 486 RGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHY 545
Query: 455 NQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLV 514
NQP WLT++QDIAN+VLL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GI E +LV
Sbjct: 546 NQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILV 605
Query: 515 ESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFA 574
E M+PLGISV RC+RLLRIFK+T++WTSLSNLVASLLNS++SIASLLLLLFLFI+IF+
Sbjct: 606 ELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFS 665
Query: 575 LLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPG 634
LLGMQLFGG+++F++T+ +RS FDNFPQAL++VFQ+LTGEDW ++MY+GIMAYGGPS G
Sbjct: 666 LLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSG 725
Query: 635 MLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKS 694
M+VCIYFIILF+CGNYILLNVFLAIAVDNLA+AESL +AQK +AEEK+R+K+++
Sbjct: 726 MIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIAR------ 779
Query: 695 EEEKSTMAKKLEQKPKGEGIPTTA-KLKIDEFESNVNEVKDPYPSADFP-----GDDEED 748
K ++ K KP+ I + K+ ID++ +E KDPYP D P ++EED
Sbjct: 780 ---KESLENKKNNKPEVNQIANSDNKVTIDDYREE-DEDKDPYPPCDVPVGEEEEEEEED 835
Query: 749 EPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLF 808
EPE+P PRPR ++EL +KEK PIPE S+FFI S TN IRV CH+++N FTN IL+F
Sbjct: 836 EPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVF 895
Query: 809 ILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYF 868
I+LSSAALAAEDPIR+ S RN IL +FD FT++FTVEI+LKMTT+GAFLHKG+FCRNYF
Sbjct: 896 IMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYF 955
Query: 869 NMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTI 928
N+LD+LVV VSL+S G++SSAISVVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TI
Sbjct: 956 NLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1015
Query: 929 GNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHR 988
GNI++VTTLLQFMFACIGVQLFKGKF+RCTD +K EECRG + +YKDGD +R R
Sbjct: 1016 GNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRER 1075
Query: 989 EWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIY 1048
W +SDF+FDNVLSAMM+LFTVSTFEGWP LLYKAIDSN E++GPIYN+RVE++IFFIIY
Sbjct: 1076 IWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIY 1135
Query: 1049 IILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQ 1108
II++AFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKNPYQ
Sbjct: 1136 IIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQ 1195
Query: 1109 YQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILK 1168
Y+ WY+V SS FEY+MF LIMLNT+CL MQHY QS+ N DILN+ FT +FT+EM+LK
Sbjct: 1196 YKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLK 1255
Query: 1169 LMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESA 1228
++AFK +GYF D WN FD LIVIGSIIDV LSE D + + + G + +ES
Sbjct: 1256 VIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPG----NSEESN 1311
Query: 1229 RISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQM 1288
RIS FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQM
Sbjct: 1312 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQM 1371
Query: 1289 FGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE 1348
FGK+A+ D QINRNNNFQTFPQAVLLLFRCATGEAWQEI+LAC GKLCDPESDY PGE
Sbjct: 1372 FGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE 1431
Query: 1349 EYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAE 1408
EYTCG+NFA YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IW+E
Sbjct: 1432 EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSE 1491
Query: 1409 YDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLF 1468
YDPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLF
Sbjct: 1492 YDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLF 1551
Query: 1469 ALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFL 1528
ALVRTALKIKTEGN EQANEELRA+IKKIWK+TSMKLLDQV+PP GDDEVTVGKFYATFL
Sbjct: 1552 ALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFL 1611
Query: 1529 IQEHFRKFMKRQEE--YYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELER 1586
IQ++FRKF KR+E+ Y K + +QAGLRT+ + PEI R +S DL +E E
Sbjct: 1612 IQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTL-HDIGPEIRRAISCDLQDDEPEET 1670
Query: 1587 AMVEAAMEEGIFRRTGGLFGQVDNFL--ERTNSLPPVMANQRPLQFAEIEM---EEMESP 1641
E E+ +F+R G L G N + +R +SL RPL + + E P
Sbjct: 1671 KREE---EDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKP 1727
Query: 1642 VFLEDFPQDPRTNPL-----------------ARANTNNANANVA-------YGNSNHSN 1677
+F P N + AN NNAN + A GN H +
Sbjct: 1728 LF------PPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVS 1781
Query: 1678 SHVFSSVH-YEREFPEETETPATR 1700
+ S H ++RE + TR
Sbjct: 1782 ENGHHSSHKHDREPQRRSSVKRTR 1805
Score = 47.0 bits (110), Expect = 2e-04
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 5/85 (5%)
Query: 1755 KSSTPGSLHEETPHSRSTRENTSRCSAPATALLIQKALVRGGLGTLAADANFIMATGQAL 1814
++ TP SL P S + + + SA + L++ L+ GLG A D F+ AT +
Sbjct: 2034 RTFTPASL--TVPSSFRNKNSDKQRSADS---LVEAVLISEGLGRYARDPKFVSATKHEI 2088
Query: 1815 ADACQMEPEEVEIMATELLKGREAP 1839
ADAC + +E+E A+ LL G P
Sbjct: 2089 ADACDLTIDEMESAASTLLNGNVRP 2113
>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform c [Homo sapiens]
Length = 2137
Score = 2266 bits (5872), Expect = 0.0
Identities = 1158/1730 (66%), Positives = 1366/1730 (78%), Gaps = 84/1730 (4%)
Query: 1 MEPSSPQDEGL---RKKQP----KKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPF 53
M S+P G RK+Q KK RP RALFCL+L NP+R+ACISIVEWKPF
Sbjct: 69 MSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPF 128
Query: 54 ETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFH 113
+ ILL IFANCVALA+Y+P PEDD+NS N LEK+EY FLI+F++E +KIIAYG L H
Sbjct: 129 DIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLH 188
Query: 114 QDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPL 173
+AY+R+GWN+LDF IV +G+F+VILEQ+ S K G DVKALRAFRVLRPL
Sbjct: 189 PNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPL 248
Query: 174 RLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDI 233
RLVSGVPSLQVVLNSI KAM+PL HIALLVLF++IIYAIIGLELF GKMHKTC+F +DI
Sbjct: 249 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDI 308
Query: 234 VATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEG 293
VA E+P+PCA +G+GR+CT NG+ECR GW GPN GIT+FDNF F+MLTV+QCITMEG
Sbjct: 309 VA---EEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEG 365
Query: 294 WTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKL 353
WTDVLYW+NDA+G E PW+YFV+L++ GSFF+LNLVLGVLSGEF+KEREKAK+RG FQKL
Sbjct: 366 WTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKL 425
Query: 354 REKQQLDEDLRGYMSWITQGEVMDVEDFREG----KLSLDEGGSDTESLY--EIAG---- 403
REKQQL+EDL+GY+ WITQ E +D E+ EG K + S+TES+ ++G
Sbjct: 426 REKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGEN 485
Query: 404 ---LNKIIQFI------RHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHH 454
+ Q I R WR+WNR R +C VKS FYWLVI++V LNTL+I+SEH+
Sbjct: 486 RGCCGSLCQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHY 545
Query: 455 NQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLV 514
NQP WLT++QDIAN+VLL+LFT EML+KMY LGL+ YF+S+FNRFDCFVVC GI E +LV
Sbjct: 546 NQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILV 605
Query: 515 ESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFA 574
E M+PLGISV RC+RLLRIFK+T++WTSLSNLVASLLNS++SIASLLLLLFLFI+IF+
Sbjct: 606 ELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFS 665
Query: 575 LLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPG 634
LLGMQLFGG+++F++T+ +RS FDNFPQAL++VFQ+LTGEDW ++MY+GIMAYGGPS G
Sbjct: 666 LLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSG 725
Query: 635 MLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKS 694
M+VCIYFIILF+CGNYILLNVFLAIAVDNLA+AESL +AQK +AEEK+R+K+++
Sbjct: 726 MIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIAR------ 779
Query: 695 EEEKSTMAKKLEQKPKGEGIPTTA-KLKIDEFESNVNEVKDPYPSADFP-----GDDEED 748
K ++ K KP+ I + K+ ID++ +E KDPYP D P ++EED
Sbjct: 780 ---KESLENKKNNKPEVNQIANSDNKVTIDDYREE-DEDKDPYPPCDVPVGEEEEEEEED 835
Query: 749 EPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLF 808
EPE+P PRPR ++EL +KEK PIPE S+FFI S TN IRV CH+++N FTN IL+F
Sbjct: 836 EPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVF 895
Query: 809 ILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYF 868
I+LSSAALAAEDPIR+ S RN IL +FD FT++FTVEI+LKMTT+GAFLHKG+FCRNYF
Sbjct: 896 IMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYF 955
Query: 869 NMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTI 928
N+LD+LVV VSL+S G++SSAISVVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI TI
Sbjct: 956 NLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1015
Query: 929 GNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHR 988
GNI++VTTLLQFMFACIGVQLFKGKF+RCTD +K EECRG + +YKDGD +R R
Sbjct: 1016 GNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRER 1075
Query: 989 EWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIY 1048
W +SDF+FDNVLSAMM+LFTVSTFEGWP LLYKAIDSN E++GPIYN+RVE++IFFIIY
Sbjct: 1076 IWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIY 1135
Query: 1049 IILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQ 1108
II++AFFMMNIFVGFVIVTFQEQGE EYKNCELDKNQRQCV+YALKARPLR YIPKNPYQ
Sbjct: 1136 IIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQ 1195
Query: 1109 YQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILK 1168
Y+ WY+V SS FEY+MF LIMLNT+CL MQHY QS+ N DILN+ FT +FT+EM+LK
Sbjct: 1196 YKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLK 1255
Query: 1169 LMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESA 1228
++AFK +GYF D WN FD LIVIGSIIDV LSE D + +ES
Sbjct: 1256 VIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEAD-------------------NSEESN 1296
Query: 1229 RISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQM 1288
RIS FFRLFRVMRL+KLLSR EG+RTLLWTFIKSFQALPYVALLI MLFFIYAVIGMQM
Sbjct: 1297 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQM 1356
Query: 1289 FGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGE 1348
FGK+A+ D QINRNNNFQTFPQAVLLLFRCATGEAWQEI+LAC GKLCDPESDY PGE
Sbjct: 1357 FGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGE 1416
Query: 1349 EYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAE 1408
EYTCG+NFA YFISFYMLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IW+E
Sbjct: 1417 EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSE 1476
Query: 1409 YDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLF 1468
YDPEAKGRIKHLDVVTLLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTV FNATLF
Sbjct: 1477 YDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLF 1536
Query: 1469 ALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFL 1528
ALVRTALKIKTEGN EQANEELRA+IKKIWK+TSMKLLDQV+PP GDDEVTVGKFYATFL
Sbjct: 1537 ALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFL 1596
Query: 1529 IQEHFRKFMKRQEE--YYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELER 1586
IQ++FRKF KR+E+ Y K + +QAGLRT+ + PEI R +S DL +E E
Sbjct: 1597 IQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTL-HDIGPEIRRAISCDLQDDEPEET 1655
Query: 1587 AMVEAAMEEGIFRRTGGLFGQVDNFL--ERTNSLPPVMANQRPLQFAEIEM---EEMESP 1641
E E+ +F+R G L G N + +R +SL RPL + + E P
Sbjct: 1656 KREE---EDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPASDTEKP 1712
Query: 1642 VFLEDFPQDPRTNPLA--RANTNNANANVAYG-NSNHSNSHVFSSVHYER 1688
+F P N + N N+ V N+N +N+++ + H +R
Sbjct: 1713 LF------PPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKR 1756
Score = 47.0 bits (110), Expect = 2e-04
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 5/85 (5%)
Query: 1755 KSSTPGSLHEETPHSRSTRENTSRCSAPATALLIQKALVRGGLGTLAADANFIMATGQAL 1814
++ TP SL P S + + + SA + L++ L+ GLG A D F+ AT +
Sbjct: 2010 RTFTPASL--TVPSSFRNKNSDKQRSADS---LVEAVLISEGLGRYARDPKFVSATKHEI 2064
Query: 1815 ADACQMEPEEVEIMATELLKGREAP 1839
ADAC + +E+E A+ LL G P
Sbjct: 2065 ADACDLTIDEMESAASTLLNGNVRP 2089
>gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F
subunit [Homo sapiens]
Length = 1977
Score = 2084 bits (5399), Expect = 0.0
Identities = 1110/1931 (57%), Positives = 1359/1931 (70%), Gaps = 176/1931 (9%)
Query: 26 RPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLG 85
R PRALFCLTL NPLR++CISIVEWKPF+ +ILLTIFANCVAL VY+P PEDD+N+ N
Sbjct: 67 RSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHN 126
Query: 86 LEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVI 145
LE++EY FL++F++E +KI+AYG + H AY+R+GWN+LDF IV +G+F+V+LEQ
Sbjct: 127 LEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGR 186
Query: 146 QSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLF 205
K G DVKALRAFRVLRPLRLVSGVPSL +VLNSI KA++PL HIALLVLF
Sbjct: 187 PGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLF 246
Query: 206 MVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGW 265
++IIYAIIGLELF G+MHKTCYF+G+D+ A E+PSPCA +GSGR CT+N +ECRG W
Sbjct: 247 VIIIYAIIGLELFLGRMHKTCYFLGSDMEA---EEDPSPCASSGSGRACTLNQTECRGRW 303
Query: 266 PGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFI 325
PGPN GIT+FDNF F+MLTV+QC+TMEGWTDVLYW+ DA+G E PW+YFV+L++ GSFF+
Sbjct: 304 PGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFV 363
Query: 326 LNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEVMDVED----- 380
LNLVLGVLSGEF+KEREKAK+RG FQK REKQQ++EDLRGY+ WITQ E +D+ED
Sbjct: 364 LNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMEDPSADD 423
Query: 381 ----------------------FREGKLS---------------LDEGGSDTESLYEIAG 403
R G+L SDT S+ E G
Sbjct: 424 NLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTETQG 483
Query: 404 ---------------LNKIIQ--FIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNT 446
LNKI++ R R+ NR+ R +C VKS YW V+L+V LNT
Sbjct: 484 DEDEEEGALASCTRCLNKIMKTRVCRRLRRANRVLRARCRRAVKSNACYWAVLLLVFLNT 543
Query: 447 LSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCS 506
L+IASEHH QP+WLT++Q+ AN+VLL LFT EML+K+YGLG Y S FNRFDCFVVC
Sbjct: 544 LTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCG 603
Query: 507 GILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLL 566
GILE LVE GAM PLGISVLRC+RLLRIFK+T++W SLSNLVASLLNS++SIASLLLLL
Sbjct: 604 GILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLL 663
Query: 567 FLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMA 626
FLFI+IF+LLGMQLFGG+++F+ T +RS FD FPQAL++VFQ+LTGEDW +MY+GIMA
Sbjct: 664 FLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMA 723
Query: 627 YGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKM 686
YGGP +PGMLVCIYFIILF+CGNYILLNVFLAIAVDNLA ++ T+ K K EK K
Sbjct: 724 YGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLASGDAGTA--KDKGGEKSNEK- 780
Query: 687 SKGLPDKSEEEKSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSADFPGDDE 746
LP ++E + K+ E+ + EG A ++ +E E ++E
Sbjct: 781 --DLPQENEGLVPGVEKEEEEGARREG----ADMEEEEEEE----------------EEE 818
Query: 747 EDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFIL 806
E+E E + L E+ KEK VPIPE S+FF S TN +R CH +++ FTN IL
Sbjct: 819 EEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLIL 878
Query: 807 LFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRN 866
+FI+LSS +LAAEDPIRA S RN IL +FD FTS+FTVEI+LKMT +GAFLH+GSFCR+
Sbjct: 879 VFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRS 938
Query: 867 YFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAIS 926
+FNMLDLLVV+VSLIS G+ SSAISVVKILRVLRVLRPLRAINRAKGLKHVVQC+FVAI
Sbjct: 939 WFNMLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIR 998
Query: 927 TIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELR 986
TIGNI++VTTLLQFMFACIGVQLFKGKF+ CTD +K T +EC+G + VY DGD + +R
Sbjct: 999 TIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVR 1058
Query: 987 HREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFI 1046
R WV+SDF+FDNVLSAMM+LFTVSTFEGWP LLYKAID+ AED GPIYN RVE+++FFI
Sbjct: 1059 ERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFI 1118
Query: 1047 IYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNP 1106
+YII+IAFFMMNIFVGFVI+TF+ QGE EY+NCELDKNQRQCV+YALKA+PLR YIPKNP
Sbjct: 1119 VYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNP 1178
Query: 1107 YQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMI 1166
+QY+VW V S+ FEYLMF LI+LNT+ L MQHY Q+ N+ DILN+ FT +FT+EM+
Sbjct: 1179 HQYRVWATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMV 1238
Query: 1167 LKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDE 1226
LK++AFK + YF D WN FD LIV+GSI+D+ ++E++ GG G ++
Sbjct: 1239 LKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNN-----------GGHLGE-SSED 1286
Query: 1227 SARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGM 1286
S+RIS FFRLFRVMRL+KLLS+ EG+RTLLWTFIKSFQALPYVALLI M+FFIYAVIGM
Sbjct: 1287 SSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGM 1346
Query: 1287 QMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAP 1346
QMFGK+AL DGTQINRNNNFQTFPQAVLLLFRCATGEAWQEI+LA G CDPESD+ P
Sbjct: 1347 QMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGP 1406
Query: 1347 GEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIW 1406
GEE+TCG+NFA YFISF+MLCAFL+INLFVAVIMDNFDYLTRDWSILGPHHLDEFK IW
Sbjct: 1407 GEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW 1466
Query: 1407 AEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNAT 1466
+EYDP AKGRIKHLDVV LLRRIQPPLGFGK CPHRVACKRLV MNMPLNSDGTVTFNAT
Sbjct: 1467 SEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVTFNAT 1526
Query: 1467 LFALVRTALKIKTEGNFEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYAT 1526
LFALVRT+LKIKTEGN EQAN+ELR +IKKIWKR KLLD+VIPP ++EVTVGKFYAT
Sbjct: 1527 LFALVRTSLKIKTEGNLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDEEEVTVGKFYAT 1586
Query: 1527 FLIQEHFRKFMKRQEE--YYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEEL 1584
FLIQ++FRKF +R+E+ +QAGLR++ ++ PE+ + ++ D EEE
Sbjct: 1587 FLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGLRSL-QDLGPEMRQALTCDTEEEEEE 1645
Query: 1585 ERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPPVMANQRP--LQFAEIEMEEMESPV 1642
+ VE E+ + + Q S+ + ++ P L F + ++ +P
Sbjct: 1646 GQEGVEEEDEKDLETNKATMVSQPSARRGSGISVSLPVGDRLPDSLSFGPSD-DDRGTPT 1704
Query: 1643 FLEDFPQDPRTNPLARANTNNANANVAY------GNSNHSNSHVFSSVHYEREFPEETET 1696
+ P A +NT+ + GNS + + + E P+
Sbjct: 1705 ------SSQPSVPQAGSNTHRRGSGALIFTIPEEGNSQPKGTKGQNKQDEDEEVPDRLS- 1757
Query: 1697 PATRGRALGQPCRVLGPHSKPCVEMLKGLLTQRAM----PRGQAPPAPCQCPRVESSMPE 1752
+A PC VL P + M L+ +R + P G+ P QC + + S +
Sbjct: 1758 -YLDEQAGTPPCSVLLPPHRAQRYMDGHLVPRRRLLPPTPAGRKPSFTIQCLQRQGSCED 1816
Query: 1753 DRKSSTPGSLHE-------------ETP-------------------------------- 1767
PG+ H TP
Sbjct: 1817 ---LPIPGTYHRGRNSGPNRAQGSWATPPQRGRLLYAPLLLVEEGAAGEGYLGRSSGPLR 1873
Query: 1768 -----HSRSTRENTSRCSAPATALLIQKALVRGGLGTLAADANFIMATGQALADACQMEP 1822
H T + S + L++ L+ GLG A D F+ Q +ADAC++
Sbjct: 1874 TFTCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVALAKQEIADACRLTL 1933
Query: 1823 EEVEIMATELL 1833
+E++ A++LL
Sbjct: 1934 DEMDNAASDLL 1944
Score = 214 bits (545), Expect = 6e-55
Identities = 174/695 (25%), Positives = 313/695 (45%), Gaps = 121/695 (17%)
Query: 10 GLRKKQPKKPVPEILPRPP-RALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVAL 68
G+ Q P +++P P A FCL+ NPLRK C +++ F +IL+ I + V+L
Sbjct: 829 GVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSL 888
Query: 69 AVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFT 128
A P+ + LG +Y F +F++E +K+ +G H+ ++ RS +N+LD
Sbjct: 889 AAEDPIRAHSFRNHILGY--FDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLL 946
Query: 129 IVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNS 188
+V + + + + H++ +S VK LR RVLRPLR ++ L+ V+
Sbjct: 947 VVSVSLISFGI--------HSSAISV------VKILRVLRVLRPLRAINRAKGLKHVVQC 992
Query: 189 IFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENE-------- 240
+F A+ + +I ++ + ++A IG++LFKGK + TC TD E
Sbjct: 993 VFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-TC----TDEAKHTPQECKGSFLVY 1047
Query: 241 EPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYW 300
+R R +N +FDN +M+ ++ T EGW +LY
Sbjct: 1048 PDGDVSRPLVRERLWVNSD-------------FNFDNVLSAMMALFTVSTFEGWPALLYK 1094
Query: 301 VNDAIGNEWPWIY---------FVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQ 351
DA + IY F+ I++ +FF++N+ +G + F + E+
Sbjct: 1095 AIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQE------- 1147
Query: 352 KLREKQQLDEDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFI 411
+ +LD++ R + + + + L + I
Sbjct: 1148 --YQNCELDKNQRQCVEYALKAQ----------------------------PLRRYIPKN 1177
Query: 412 RH-WRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRV 470
H +R W V S F +L+ L++ LNT+++A +H+ Q DI N V
Sbjct: 1178 PHQYRVW---------ATVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMV 1228
Query: 471 LLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVE----------SGAMT 520
LFT EM++K+ + YF +N FD +V I++I + E S +
Sbjct: 1229 FTGLFTIEMVLKIIAFKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSS 1288
Query: 521 PLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQL 580
+ I+ R R++R+ K+ + L+ + + S +++ + LL+ + I+A++GMQ+
Sbjct: 1289 RISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQM 1348
Query: 581 FGGRYDFEDTEV-RRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYG-------GP-- 630
FG + T++ R +NF FPQA++ +F+ TGE W +M + GP
Sbjct: 1349 FGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGE 1408
Query: 631 --SYPGMLVCIYFIILFVCGNYILLNVFLAIAVDN 663
+ YFI F+ ++++N+F+A+ +DN
Sbjct: 1409 EFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDN 1443
Score = 114 bits (286), Expect = 7e-25
Identities = 100/357 (28%), Positives = 155/357 (43%), Gaps = 54/357 (15%)
Query: 767 KEKAVPIPEAS----SFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPI 822
K K V + A + F + N +R C IV F ILL I + AL P
Sbjct: 56 KHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPF 115
Query: 823 RADSMR--NQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSL 880
D N L+ + F +FTVE VLK+ YG LH ++ RN +N+LD ++V V L
Sbjct: 116 PEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGL 175
Query: 881 ISMGLESSAISV--------------VKILRVLRVLRPLRAINRAKGLKHVVQCMFVAIS 926
S+ LE VK LR RVLRPLR ++ L V+ + A+
Sbjct: 176 FSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALV 235
Query: 927 TIGNIVLVTTLLQFMFACIGVQLFKGKFFR-CTDLSKMTEEECRGYYYVYKDGDPM---- 981
+ +I L+ + ++A IG++LF G+ + C L E E +D P
Sbjct: 236 PLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAE--------EDPSPCASSG 287
Query: 982 --------QIELRHREWVHSD---FHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAED 1030
Q E R R W + +FDN AM+++F T EGW +LY D+ +
Sbjct: 288 SGRACTLNQTECRGR-WPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYE 346
Query: 1031 VGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQ 1087
+ +Y F+ +I +FF++N+ +G + F ++ E + K + +
Sbjct: 347 LPWVY---------FVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREK 394
>gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo
sapiens]
Length = 2261
Score = 737 bits (1903), Expect = 0.0
Identities = 384/825 (46%), Positives = 531/825 (64%), Gaps = 60/825 (7%)
Query: 728 NVNEVKDPYPSADFPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNK 787
N N DP P + +EE++ P+P +P SS FI S TN
Sbjct: 1187 NKNANPDPLPKKEEEKKEEEEDDRGEDGPKP--------------MPPYSSMFILSTTNP 1232
Query: 788 IRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEI 847
+R LCH I+N +F IL+ I +SS ALAAEDP++ ++ RN +L++FD FT VFT E+
Sbjct: 1233 LRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEM 1292
Query: 848 VLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSA----ISVVKILRVLRVLR 903
V+KM G LH+G++ R+ +N+LD +VV+ +L++ ++ I+ +K LRVLRVLR
Sbjct: 1293 VIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLR 1352
Query: 904 PLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKM 963
PL+ I R LK V C+ ++ + NI++V L F+FA + VQLFKGKFF CTD SK
Sbjct: 1353 PLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKE 1412
Query: 964 TEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKA 1023
E++CRG Y +Y+ + ++ R REW +FH+DNVL A+++LFTVST EGWPQ+L +
Sbjct: 1413 FEKDCRGKYLLYEKNE---VKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHS 1469
Query: 1024 IDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDK 1083
+D+ E+ GP R+EM+IF+++Y ++ FF +NIFV +I+TFQEQG+ + L+K
Sbjct: 1470 VDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEK 1529
Query: 1084 NQRQCVQYALKARPLRCYIPKNP--YQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYN 1141
N+R C+ +A+ A+PL ++P+N +QY++W V S FEY + A+I LNTI L M+ Y
Sbjct: 1530 NERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYG 1589
Query: 1142 QSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSE 1201
S + + N+ FT +F+LE +LK+MAF YF D WN+FDF+ V+GSI D++++E
Sbjct: 1590 ASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTE 1649
Query: 1202 IDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFI 1261
I+ +F RLFR RLIKLL + +R LLWTF+
Sbjct: 1650 FGNNF-----------------------INLSFLRLFRAARLIKLLRQGYTIRILLWTFV 1686
Query: 1262 KSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL--------VDGTQINRNNNFQTFPQAV 1313
+SF+ALPYV LLI MLFFIYA+IGMQ+FG I + D QI +NNF+TF QA+
Sbjct: 1687 QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQAL 1746
Query: 1314 LLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVI 1373
+LLFR ATGEAW I+L+C GK CD S E CG FAY+YF+SF LC+FL++
Sbjct: 1747 MLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRE---CGNEFAYFYFVSFIFLCSFLML 1803
Query: 1374 NLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPL 1433
NLFVAVIMDNF+YLTRD SILGPHHLDE+ +WAEYDP A GRI + D+ +LLR I PPL
Sbjct: 1804 NLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPL 1863
Query: 1434 GFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTE---GNFEQANEEL 1490
G GK CPHRVACKRL+ M++P+ D TV FN+TL AL+RTAL IK + +Q + EL
Sbjct: 1864 GLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAEL 1923
Query: 1491 RAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRK 1535
R + IW S K LD ++ P ++TVGK YA +I E++R+
Sbjct: 1924 RKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQ 1968
Score = 628 bits (1619), Expect = e-179
Identities = 338/716 (47%), Positives = 457/716 (63%), Gaps = 55/716 (7%)
Query: 29 RALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEK 88
R+LF + +N +RK I EW PFE +IL TI ANC+ LA+ +P+DD ++ L+
Sbjct: 76 RSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDD 135
Query: 89 LEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSH 148
E +F+ +F EA +KIIA GF FH+ +YLR+GWNV+DF +V G+ +
Sbjct: 136 TEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATV---------- 185
Query: 149 TAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVI 208
G D++ LRA RVLRPL+LVSG+PSLQVVL SI KAM+PL I LL+ F ++
Sbjct: 186 -------GTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAIL 238
Query: 209 IYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGP 268
I+AIIGLE + GK H TC+ GTD ++ E P+PC R C NG++C+ W GP
Sbjct: 239 IFAIIGLEFYMGKFHTTCFEEGTD---DIQGESPAPCGTEEPARTCP-NGTKCQPYWEGP 294
Query: 269 NHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNL 328
N+GIT FDN F++LTV+QCITMEGWTD+LY NDA GN W W+YF+ LI++GSFF+LNL
Sbjct: 295 NNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNL 354
Query: 329 VLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQG-EVMDVEDFREG--- 384
VLGVLSGEF KERE+ ++R F KLR +QQ++ +L GYM WI++ EV+ ED +G
Sbjct: 355 VLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQR 414
Query: 385 ---------------KLSLDEGGSDTESLYEIAGL----------NKIIQFIRHWRQWNR 419
K L + L +IA + + ++ + + R
Sbjct: 415 HPFDGALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKER 474
Query: 420 IFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEM 479
R+ +VK++ FYW V+ +VALNTL +A H+NQP WL+ A + L LF +EM
Sbjct: 475 RMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEM 534
Query: 480 LMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKIT 539
+KMYGLG R YF S FN FDC V+ I E++ T GISVLR +RLLRIFK+T
Sbjct: 535 FIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVT 594
Query: 540 KYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDN 599
KYW SL NLV SLLNS++SI SLL LLFLFIV+FALLGMQLFGG+++F D +NFD
Sbjct: 595 KYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF-DEGTPPTNFDT 653
Query: 600 FPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAI 659
FP A+++VFQ+LTGEDW +MY+GI + GG GM+ IYFI+L + GNY LLNVFLAI
Sbjct: 654 FPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-GGMVFSIYFIVLTLFGNYTLLNVFLAI 712
Query: 660 AVDNLAEAESLTSAQKAK---AEEKKRRKMSKGLPDKSEEEKSTMAKKLEQKPKGE 712
AVDNLA A+ LT ++ + A +K + +K + + S + M+ ++++ K +
Sbjct: 713 AVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQ 768
Score = 221 bits (562), Expect = 7e-57
Identities = 176/690 (25%), Positives = 323/690 (46%), Gaps = 104/690 (15%)
Query: 2 EPSSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTI 61
E ++E R + KP+P P ++F L+ NPLR+ C I+ + FE IL+ I
Sbjct: 1200 EEKKEEEEDDRGEDGPKPMP-----PYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVI 1254
Query: 62 FANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSG 121
+ +ALA P+ N N L +Y F VF+ E +K+I G + HQ AY R
Sbjct: 1255 AMSSIALAAEDPV--QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDL 1312
Query: 122 WNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLD-VKALRAFRVLRPLRLVSGVP 180
WN+LDF +V + + +SKG ++ +K+LR RVLRPL+ + +P
Sbjct: 1313 WNILDFIVVS-----------GALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLP 1361
Query: 181 SLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENE 240
L+ V + + ++ +F+I ++ + + I+A++ ++LFKGK +F TD E++
Sbjct: 1362 KLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGK-----FFHCTD-----ESK 1411
Query: 241 EPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVL-Y 299
E R G+ +E + H+DN +++LT++ T EGW VL +
Sbjct: 1412 EFEKDCR---GKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKH 1468
Query: 300 WVNDAIGNEWP--------WIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQ 351
V+ N+ P I++V ++ FF +N+ + ++ F ++ +
Sbjct: 1469 SVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGD--------- 1519
Query: 352 KLREKQQLDEDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFI 411
K+ E+ L+++ R + + + +
Sbjct: 1520 KMMEEYSLEKNERACIDFAISAKPL----------------------------------T 1545
Query: 412 RHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVL 471
RH Q + F+++ V S F + ++ ++ALNT+ + + + + + N V
Sbjct: 1546 RHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVF 1605
Query: 472 LSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIR 531
SLF+ E ++K+ G+ YF +N FD V I +IL+ E G + +S LR R
Sbjct: 1606 TSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG-NNFINLSFLRLFR 1664
Query: 532 LLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGG-RYDFEDT 590
R+ K+ + ++ L+ + + S +++ + LL+ + I+A++GMQ+FG D ED
Sbjct: 1665 AARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDE 1724
Query: 591 E--------VRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGML------ 636
+ +NF F QAL+ +F+ TGE W ++M + + G+L
Sbjct: 1725 DSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGN 1784
Query: 637 --VCIYFI-ILFVCGNYILLNVFLAIAVDN 663
YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 1785 EFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1813
Score = 127 bits (319), Expect = 1e-28
Identities = 151/704 (21%), Positives = 294/704 (41%), Gaps = 121/704 (17%)
Query: 434 FYWLVILIVALNTLSIASEHH---NQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLR- 489
F ++++ + N + +A E H + ++ D + +F E +K+ LG
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 490 ---QYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLS 546
Y + +N D VV +GIL + E T LR +R+LR K+ SL
Sbjct: 160 HKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT------LRAVRVLRPLKLVSGIPSLQ 213
Query: 547 NLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYD---FED-------------- 589
++ S++ ++ + + LLLF I+IFA++G++ + G++ FE+
Sbjct: 214 VVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCG 273
Query: 590 -TEVRRS-------------------NFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGG 629
E R+ FDN A+++VFQ +T E WT ++YN A G
Sbjct: 274 TEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGN 333
Query: 630 PSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKG 689
+YFI L + G++ +LN+ L + A+ ++A + ++++++ +
Sbjct: 334 TWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
Query: 690 LPDKSEE-EKSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSADFPGDDEED 748
L E K+ E + GE + F+ + D +E +
Sbjct: 389 LNGYMEWISKAEEVILAEDETDGE--------QRHPFDGALRRTTIKKSKTDLLNPEEAE 440
Query: 749 EPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLF 808
+ ++ P A +K + E S+FF ++R R+V F +L
Sbjct: 441 DQLADIASVGSPFARASIKSAKL---ENSTFF-HKKERRMRFYIRRMVKTQAFYWTVLSL 496
Query: 809 ILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYF 868
+ L++ +A + + + + L + + F +F E+ +KM YG L + + F
Sbjct: 497 VALNTLCVAIVHYNQPEWL-SDFLYYAEFIFLGLFMSEMFIKM--YG--LGTRPYFHSSF 551
Query: 869 NMLDLLVVAVSLISM---GLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAI 925
N D V+ S+ + ++ + +LR LR+LR + L+++V + ++
Sbjct: 552 NCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSM 611
Query: 926 STIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIEL 985
+I +++ + L +FA +G+QLF G+F + +G P
Sbjct: 612 KSIISLLFLLFLFIVVFALLGMQLFGGQFN-------------------FDEGTPPT--- 649
Query: 986 RHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFF 1045
+FD +A+M++F + T E W +++Y I S G + V +I+F
Sbjct: 650 ----------NFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQ----GGVQGGMV-FSIYF 694
Query: 1046 IIYIILIAFFMMNIFVGFVI--------VTFQEQGETEYKNCEL 1081
I+ + + ++N+F+ + +T EQ E E N +L
Sbjct: 695 IVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKL 738
Score = 108 bits (270), Expect = 5e-23
Identities = 80/301 (26%), Positives = 138/301 (45%), Gaps = 50/301 (16%)
Query: 1094 KARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDIL 1153
K R +R YI + +V + F + + +L+ LNT+C+ + HYNQ E ++
Sbjct: 472 KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 522
Query: 1154 NVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLY 1213
F +F EM +K+ R YF +N FD ++IGSI +VI + I
Sbjct: 523 EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVI----------- 571
Query: 1214 CLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALL 1273
P S IS R R++R+ K+ +R L+ + + S +++ + L
Sbjct: 572 ---------KPGTSFGIS--VLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFL 620
Query: 1274 IVMLFFIYAVIGMQMF-GKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLAC 1332
+ + ++A++GMQ+F G+ +GT NF TFP A++ +F+ TGE W E++
Sbjct: 621 LFLFIVVFALLGMQLFGGQFNFDEGTP---PTNFDTFPAAIMTVFQILTGEDWNEVMY-- 675
Query: 1333 SYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNF---DYLTR 1389
D + G YFI + + ++N+F+A+ +DN LT+
Sbjct: 676 ----------DGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK 725
Query: 1390 D 1390
D
Sbjct: 726 D 726
Score = 102 bits (253), Expect = 5e-21
Identities = 86/326 (26%), Positives = 154/326 (47%), Gaps = 23/326 (7%)
Query: 778 SFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMR--NQILKHF 835
S F+FS N +R +I F IL I+ + LA E + D ++ L
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 836 DIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLI-SMGLESSAISVVK 894
+ F +F E +K+ G HKGS+ RN +N++D +VV ++ ++G E ++
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
Query: 895 ILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKF 954
LR +RVLRPL+ ++ L+ V++ + A+ + I L+ +FA IG++ + GKF
Sbjct: 193 TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
Query: 955 FR------CTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLF 1008
D+ + C + + + + FDN+L A++++F
Sbjct: 253 HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVF 312
Query: 1009 TVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTF 1068
T EGW LLY + D++ G +N ++FI II+ +FFM+N+ +G + F
Sbjct: 313 QCITMEGWTDLLYNSNDAS----GNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEF 363
Query: 1069 -QEQGETEYKNCELDKNQRQCVQYAL 1093
+E+ E + L ++Q ++ L
Sbjct: 364 AKERERVENRRAFLKLRRQQQIEREL 389
Score = 99.4 bits (246), Expect = 3e-20
Identities = 80/300 (26%), Positives = 152/300 (50%), Gaps = 51/300 (17%)
Query: 425 CHDIVKSKVFYWLVILIVALNTLSIASEHHNQP-LWLTRLQDIANRVLLSLFTTEMLMKM 483
CH I+ + F +++++A++++++A+E QP + + V +FT EM++KM
Sbjct: 1237 CHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKM 1296
Query: 484 YGLGL----RQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKIT 539
LGL YF ++N D F+V SG L + +G I+ ++ +R+LR+ +
Sbjct: 1297 IDLGLVLHQGAYFRDLWNILD-FIVVSGAL-VAFAFTGNSKGKDINTIKSLRVLRVLRPL 1354
Query: 540 KYWTSLSNLVA---SLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYD---------- 586
K L L A ++NS++++ ++L++ LF+ IFA++ +QLF G++
Sbjct: 1355 KTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFE 1414
Query: 587 ---------FEDTEVR---------RSNFDNFPQALISVFQVLTGEDWTSMMYNGIMA-- 626
+E EV+ ++DN AL+++F V TGE W ++ + + A
Sbjct: 1415 KDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1474
Query: 627 -YGGPSYPG--MLVCIYFIILFVCGNYILLNVFLAIAV-------DNLAEAESLTSAQKA 676
GPS PG M + I++++ FV + +N+F+A+ + D + E SL ++A
Sbjct: 1475 ENQGPS-PGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERA 1533
Score = 75.1 bits (183), Expect = 6e-13
Identities = 71/322 (22%), Positives = 129/322 (40%), Gaps = 69/322 (21%)
Query: 34 LTLENPLRKACISIVEWK-----PFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEK 88
LT P K W+ PFE I+ I N + L + + + L
Sbjct: 1544 LTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKF---YGASVAYENALRV 1600
Query: 89 LEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSH 148
F +FS+E +K++A+G L Y R WN+ DF V + +++ +
Sbjct: 1601 FNIVFTSLFSLECVLKVMAFGIL----NYFRDAWNIFDFVTVLGSITDILVTEFG----- 1651
Query: 149 TAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVI 208
+++ LR FR R ++L+ +++++L + ++ L ++ LL+ +
Sbjct: 1652 -------NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1704
Query: 209 IYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGP 268
IYAIIG+++F IG D+ +E+ +
Sbjct: 1705 IYAIIGMQVFGN--------IGIDVEDEDSDEDEFQITEHNN------------------ 1738
Query: 269 NHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV--------NDAI-----GNEWPWIYFV 315
F F +++ +++ T E W +++ N I GNE+ + YFV
Sbjct: 1739 ------FRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFV 1792
Query: 316 TLILLGSFFILNLVLGVLSGEF 337
+ I L SF +LNL + V+ F
Sbjct: 1793 SFIFLCSFLMLNLFVAVIMDNF 1814
Score = 67.4 bits (163), Expect = 1e-10
Identities = 68/308 (22%), Positives = 119/308 (38%), Gaps = 87/308 (28%)
Query: 1120 FEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVA---FTIIFTLEMILKLMA----F 1172
FEY++ A I+ N I L ++ + + +S+ L+ F IF E +K++A F
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 1173 KARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISS 1232
Y + WNV DF++V+ I+ + +E D
Sbjct: 160 HKGSYLRNGWNVMDFVVVLTGILATVGTEFDL---------------------------- 191
Query: 1233 AFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GK 1291
R RV+R +KL+S ++ +L + +K+ L + LL+ I+A+IG++ + GK
Sbjct: 192 RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGK 251
Query: 1292 I---------------------------ALVDGTQI-----NRNNNFQTFPQ---AVLLL 1316
+GT+ NN F AVL +
Sbjct: 252 FHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTV 311
Query: 1317 FRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLF 1376
F+C T E W ++L G + + YFI ++ +F ++NL
Sbjct: 312 FQCITMEGWTDLLY----------------NSNDASGNTWNWLYFIPLIIIGSFFMLNLV 355
Query: 1377 VAVIMDNF 1384
+ V+ F
Sbjct: 356 LGVLSGEF 363
>gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B
subunit [Homo sapiens]
Length = 2339
Score = 735 bits (1898), Expect = 0.0
Identities = 380/773 (49%), Positives = 513/773 (66%), Gaps = 38/773 (4%)
Query: 772 PIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQI 831
PI SS F SPTN +R CH IV +F IL+ I LSS ALAAEDP+R DS RN
Sbjct: 1123 PIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNA 1182
Query: 832 LKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSA-- 889
LK+ D FT VFT E+V+KM G LH G++ R+ +N+LD +VV+ +L++ S
Sbjct: 1183 LKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGK 1242
Query: 890 -ISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQ 948
I+ +K LRVLRVLRPL+ I R LK V C+ ++ + NI++V L F+FA I VQ
Sbjct: 1243 DINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQ 1302
Query: 949 LFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLF 1008
LFKGKFF CTD SK E +CRG Y Y + ++E + R+W DFH+DNVL A+++LF
Sbjct: 1303 LFKGKFFYCTDESKELERDCRGQYLDY---EKEEVEAQPRQWKKYDFHYDNVLWALLTLF 1359
Query: 1009 TVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTF 1068
TVST EGWP +L ++D+ E+ GP R+E++IF+++Y ++ FF +NIFV +I+TF
Sbjct: 1360 TVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF 1419
Query: 1069 QEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKN--PYQYQVWYIVTSSYFEYLMFA 1126
QEQG+ C L+KN+R C+ +A+ A+PL Y+P+N +QY+ W V S FEY + A
Sbjct: 1420 QEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMA 1479
Query: 1127 LIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFD 1186
+I LNT+ L M+ Y+ + + LN+ FT +F++E +LK++AF YF D WNVFD
Sbjct: 1480 MIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFD 1539
Query: 1187 FLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKL 1246
F+ V+GSI D++++EI + + I+ +F RLFR RLIKL
Sbjct: 1540 FVTVLGSITDILVTEI---------------------AETNNFINLSFLRLFRAARLIKL 1578
Query: 1247 LSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNF 1306
L + +R LLWTF++SF+ALPYV LLI MLFFIYA+IGMQ+FG IAL D T INR+NNF
Sbjct: 1579 LRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNF 1638
Query: 1307 QTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYM 1366
+TF QA++LLFR ATGEAW EI+L+C + CD +++ CG++FAY+YF+SF
Sbjct: 1639 RTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATE-----CGSDFAYFYFVSFIF 1693
Query: 1367 LCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLL 1426
LC+FL++NLFVAVIMDNF+YLTRD SILGPHHLDEF +WAEYDP A GRI + D+ +L
Sbjct: 1694 LCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEML 1753
Query: 1427 RRIQPPLGFGKFCPHRVACKRLVGMNMPL-NSDGTVTFNATLFALVRTALKIK---TEGN 1482
+ + PPLG GK CP RVA KRLV MNMP+ N D TV F +TL AL+RTAL+IK
Sbjct: 1754 KHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTK 1813
Query: 1483 FEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRK 1535
Q + ELR I +W K LD ++PP DE+TVGK YA +I + +++
Sbjct: 1814 QHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQ 1866
Score = 617 bits (1591), Expect = e-176
Identities = 337/687 (49%), Positives = 447/687 (65%), Gaps = 53/687 (7%)
Query: 29 RALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEK 88
R+LF + +N +RK I EW PFE +IL TI ANC+ LA+ +P+ D ++ L+
Sbjct: 73 RSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDD 132
Query: 89 LEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSH 148
E +F+ +F EA +KIIA GF+FH+ +YLR+GWNV+DF +V G+
Sbjct: 133 TEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGI-------------- 178
Query: 149 TAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVI 208
+++ G D++ LRA RVLRPL+LVSG+PSLQVVL SI KAM+PL I LL+ F ++
Sbjct: 179 ---LATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIL 235
Query: 209 IYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGP 268
++AIIGLE + GK HK C+ TD E PC + R C +ECR WPGP
Sbjct: 236 MFAIIGLEFYMGKFHKACFPNSTD----AEPVGDFPCGKEAPARLCE-GDTECREYWPGP 290
Query: 269 NHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNL 328
N GIT+FDN F++LTV+QCITMEGWTD+LY NDA GN W W+YF+ LI++GSFF+LNL
Sbjct: 291 NFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNL 350
Query: 329 VLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQG-EVMDVEDFR--EGK 385
VLGVLSGEF KERE+ ++R F KLR +QQ++ +L GY+ WI + EVM E+ R E K
Sbjct: 351 VLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEK 410
Query: 386 LSLD-----------------EGGSD-------TESLYEIAGLNK-IIQFIRHWRQWNRI 420
LD E G D S + A L + ++R+ ++
Sbjct: 411 SPLDVLKRAATKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKM 470
Query: 421 FRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEML 480
FR+ +VK++ FYW+V+ +VALNTL +A H+NQP LT A V L LF TEM
Sbjct: 471 FRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMS 530
Query: 481 MKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITK 540
+KMYGLG R YF S FN FD V+ + E++ + GISVLR +RLLRIFK+TK
Sbjct: 531 LKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTK 590
Query: 541 YWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNF 600
YW+SL NLV SLLNS++SI SLL LLFLFIV+FALLGMQLFGG+++F+D E +NFD F
Sbjct: 591 YWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQD-ETPTTNFDTF 649
Query: 601 PQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIA 660
P A+++VFQ+LTGEDW ++MY+GI + GG S GM YFI+L + GNY LLNVFLAIA
Sbjct: 650 PAAILTVFQILTGEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLFGNYTLLNVFLAIA 708
Query: 661 VDNLAEAESLTSAQKAKAEEKKRRKMS 687
VDNLA A+ LT ++ + EE +K++
Sbjct: 709 VDNLANAQELTKDEE-EMEEAANQKLA 734
Score = 218 bits (555), Expect = 4e-56
Identities = 173/656 (26%), Positives = 300/656 (45%), Gaps = 90/656 (13%)
Query: 27 PPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGL 86
P ++FCL+ N LR+ C IV + FE +IL+ I + +ALA P+ D N L
Sbjct: 1126 PYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPR--NNAL 1183
Query: 87 EKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQ 146
+ L+Y F VF+ E +K+I G L H AY R WN+LDF IV G
Sbjct: 1184 KYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDF-IVVSGALVAF-------- 1234
Query: 147 SHTAPMSSKGAGLD-VKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLF 205
A SKG ++ +K+LR RVLRPL+ + +P L+ V + + ++ + +I ++ +
Sbjct: 1235 ---AFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYML 1291
Query: 206 MVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGW 265
+ I+A+I ++LFKGK +F TD E R G+ E
Sbjct: 1292 FMFIFAVIAVQLFKGK-----FFYCTD--------ESKELERDCRGQYLDYEKEEVEAQP 1338
Query: 266 PGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWP---------WIYFVT 316
H+DN +++LT++ T EGW VL DA E I++V
Sbjct: 1339 RQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVV 1398
Query: 317 LILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEVM 376
++ FF +N+ + ++ F ++ +K S + +K E+ +D +
Sbjct: 1399 YFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEK-NERACIDFAISAK---------- 1447
Query: 377 DVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFIRHWRQWNRIFRWKCHDIVKSKVFYW 436
R+ Q + F++K V S F +
Sbjct: 1448 --------------------------------PLTRYMPQNRQSFQYKTWTFVVSPPFEY 1475
Query: 437 LVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIF 496
++ ++ALNT+ + + ++ P + N V S+F+ E ++K+ G+ YF +
Sbjct: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAW 1535
Query: 497 NRFDCFVVCSGILEILLVESGAMTP-LGISVLRCIRLLRIFKITKYWTSLSNLVASLLNS 555
N FD V I +IL+ E + +S LR R R+ K+ + ++ L+ + + S
Sbjct: 1536 NVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1595
Query: 556 IRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEV-RRSNFDNFPQALISVFQVLTGE 614
+++ + LL+ + I+A++GMQ+FG +DT + R +NF F QAL+ +F+ TGE
Sbjct: 1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGE 1655
Query: 615 DWTSMMYNGIMAYGGPSYPGMLVC------IYFI-ILFVCGNYILLNVFLAIAVDN 663
W +M + + C YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 1656 AWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1710
Score = 130 bits (326), Expect = 2e-29
Identities = 159/714 (22%), Positives = 301/714 (42%), Gaps = 127/714 (17%)
Query: 434 FYWLVILIVALNTLSIASEHH----NQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGL- 488
F ++++ + N + +A E H ++ RL D + +F E +K+ LG
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDD-TEPYFIGIFCFEAGIKIIALGFV 155
Query: 489 ---RQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSL 545
Y + +N D VV +GIL + A T + LR +R+LR K+ SL
Sbjct: 156 FHKGSYLRNGWNVMDFVVVLTGIL------ATAGTDFDLRTLRAVRVLRPLKLVSGIPSL 209
Query: 546 SNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY---------------DFE-- 588
++ S++ ++ + + LLLF I++FA++G++ + G++ DF
Sbjct: 210 QVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269
Query: 589 ----------DTEVRR---------SNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGG 629
DTE R +NFDN A+++VFQ +T E WT ++YN A G
Sbjct: 270 KEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGN 329
Query: 630 PSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKG 689
+YFI L + G++ +LN+ L + A+ ++A + ++++++ +
Sbjct: 330 TWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 384
Query: 690 LPDKSEEEKSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSA---DFPGDDE 746
L LE K E + + + E +S ++ +K D +E
Sbjct: 385 LNGY-----------LEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEE 433
Query: 747 EDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFIL 806
++ L P A LK E+SS+F R R+V A F +L
Sbjct: 434 GEDRFADLCAVGSPFARASLKSGKT---ESSSYFR-RKEKMFRFFIRRMVKAQSFYWVVL 489
Query: 807 LFILLSSAALAA---EDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSF 863
+ L++ +A P R + L + F +F E+ LKM YG L S+
Sbjct: 490 CVVALNTLCVAMVHYNQPRRLTTT----LYFAEFVFLGLFLTEMSLKM--YG--LGPRSY 541
Query: 864 CRNYFNMLDLLVVAVSLISM---GLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQC 920
R+ FN D V+ S+ + ++ + + +LR LR+LR + L+++V
Sbjct: 542 FRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVS 601
Query: 921 MFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDP 980
+ ++ +I +++ + L +FA +G+QLF G+F ++D P
Sbjct: 602 LLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN-------------------FQDETP 642
Query: 981 MQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVE 1040
+FD +A++++F + T E W ++Y I+S +++
Sbjct: 643 TT-------------NFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFS---- 685
Query: 1041 MAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDK--NQRQCVQYA 1092
+ +FI+ + + ++N+F+ + E E+++ NQ+ +Q A
Sbjct: 686 -SFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKA 738
Score = 112 bits (280), Expect = 3e-24
Identities = 74/288 (25%), Positives = 139/288 (48%), Gaps = 41/288 (14%)
Query: 1107 YQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMI 1166
+++ + +V + F +++ ++ LNT+C+ M HYNQ ++ F +F EM
Sbjct: 471 FRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMS 530
Query: 1167 LKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDE 1226
LK+ R YF +N FDF +++GS+ +V+ + I P
Sbjct: 531 LKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAI--------------------KPGS 570
Query: 1227 SARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGM 1286
S IS R R++R+ K+ +R L+ + + S +++ + L+ + ++A++GM
Sbjct: 571 SFGIS--VLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGM 628
Query: 1287 QMF-GKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYA 1345
Q+F G+ D T NF TFP A+L +F+ TGE W ++ +G + + +
Sbjct: 629 QLFGGQFNFQDETP---TTNFDTFPAAILTVFQILTGEDWNAVMY---HG--IESQGGVS 680
Query: 1346 PGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNF---DYLTRD 1390
G F+ +YFI + + ++N+F+A+ +DN LT+D
Sbjct: 681 KG-------MFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 721
Score = 111 bits (277), Expect = 8e-24
Identities = 92/325 (28%), Positives = 157/325 (48%), Gaps = 22/325 (6%)
Query: 778 SFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAED--PIRADSMRNQILKHF 835
S F+FS N +R RI F IL I+ + LA E P + ++ L
Sbjct: 74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133
Query: 836 DIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKI 895
+ F +F E +K+ G HKGS+ RN +N++D +VV +++ + ++
Sbjct: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRT 190
Query: 896 LRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFF 955
LR +RVLRPL+ ++ L+ V++ + A+ + I L+ MFA IG++ + GKF
Sbjct: 191 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFH 250
Query: 956 RCTDLSKMTEEECRGYYYVYKDGDPMQIE--LRHRE-WVHSDF---HFDNVLSAMMSLFT 1009
+ T+ E G + K+ E RE W +F +FDN+L A++++F
Sbjct: 251 KAC-FPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQ 309
Query: 1010 VSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTF- 1068
T EGW +LY D+ G +N ++FI II+ +FFM+N+ +G + F
Sbjct: 310 CITMEGWTDILYNTNDA----AGNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFA 360
Query: 1069 QEQGETEYKNCELDKNQRQCVQYAL 1093
+E+ E + L ++Q ++ L
Sbjct: 361 KERERVENRRAFLKLRRQQQIEREL 385
Score = 101 bits (251), Expect = 8e-21
Identities = 78/288 (27%), Positives = 143/288 (49%), Gaps = 45/288 (15%)
Query: 420 IFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVL----LSLF 475
+ R CH IV + F ++++++AL+++++A+E P+ ++ A + L +F
Sbjct: 1138 LLRRFCHYIVTMRYFEVVILVVIALSSIALAAE---DPVRTDSPRNNALKYLDYIFTGVF 1194
Query: 476 TTEMLMKMYGLGLR----QYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIR 531
T EM++KM LGL YF ++N D VV ++ S I LR +R
Sbjct: 1195 TFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLR 1254
Query: 532 LLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY------ 585
+LR K K L + ++NS++++ ++L++ LF+ IFA++ +QLF G++
Sbjct: 1255 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDE 1314
Query: 586 -------------DFEDTEVRRS---------NFDNFPQALISVFQVLTGEDWTSMMYNG 623
D+E EV ++DN AL+++F V TGE W ++ +
Sbjct: 1315 SKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHS 1374
Query: 624 IMA---YGGPSYPG--MLVCIYFIILFVCGNYILLNVFLAIAVDNLAE 666
+ A GPS PG M + I++++ FV + +N+F+A+ + E
Sbjct: 1375 VDATYEEQGPS-PGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQE 1421
Score = 85.1 bits (209), Expect = 6e-16
Identities = 87/391 (22%), Positives = 164/391 (41%), Gaps = 84/391 (21%)
Query: 47 IVEWKPFETIILLTIFAN--CVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMK 104
+V+ + F ++L + N CVA+ Y + L L E+ FL +F E ++K
Sbjct: 478 MVKAQSFYWVVLCVVALNTLCVAMVHY-----NQPRRLTTTLYFAEFVFLGLFLTEMSLK 532
Query: 105 IIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKAL 164
+ G +Y RS +N DF ++ VF V+ + G+ + L
Sbjct: 533 MYGLG----PRSYFRSSFNCFDFGVIVGSVFEVVWAAIK-----------PGSSFGISVL 577
Query: 165 RAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHK 224
RA R+LR ++ SL+ ++ S+ +M + + L+ ++++A++G++LF G+ +
Sbjct: 578 RALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN- 636
Query: 225 TCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLT 284
++E P+ T+FD F ++LT
Sbjct: 637 ------------FQDETPT-----------------------------TNFDTFPAAILT 655
Query: 285 VYQCITMEGWTDVLYWVNDAIG----NEWPWIYFVTLILLGSFFILNLVLGVL------S 334
V+Q +T E W V+Y ++ G + YF+ L L G++ +LN+ L + +
Sbjct: 656 VFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANA 715
Query: 335 GEFTKEREK----AKSRGTFQKLREKQQLDEDLRGYMSWITQ----GEVMDVEDFREGKL 386
E TK+ E+ A + QK +E ++ +S + + V + R +L
Sbjct: 716 QELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQL 775
Query: 387 SLDEGGSDTESLYEIAGLNKIIQF--IRHWR 415
L + E+LY + ++F RH R
Sbjct: 776 RLQNLRASCEALYSEMDPEERLRFATTRHLR 806
Score = 82.8 bits (203), Expect = 3e-15
Identities = 79/354 (22%), Positives = 152/354 (42%), Gaps = 68/354 (19%)
Query: 1066 VTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMF 1125
V + Q E + K E D R + + + C P N + YIVT YFE ++
Sbjct: 1099 VDLESQAEGK-KEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVIL 1157
Query: 1126 ALIMLNTICLGMQHYNQSEQ-MNHISDILNVAFTIIFTLEMILKL----MAFKARGYFGD 1180
+I L++I L + +++ N+ L+ FT +FT EM++K+ + YF D
Sbjct: 1158 VVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRD 1217
Query: 1181 PWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRV 1240
WN+ DF++V G+++ S G +++ +S R+ RV
Sbjct: 1218 LWNILDFIVVSGALVAFAFS---------------GSKGKDINTIKSLRV-------LRV 1255
Query: 1241 MRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GKI--ALVDG 1297
+R +K + R ++ + + S + + + ++ ++ FI+AVI +Q+F GK +
Sbjct: 1256 LRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDES 1315
Query: 1298 TQINR------------------------NNNFQTFPQAVLLLFRCATGEAWQEIL---L 1330
++ R + ++ A+L LF +TGE W +L +
Sbjct: 1316 KELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSV 1375
Query: 1331 ACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNF 1384
+Y E +PG +++ ++++ F +N+FVA+I+ F
Sbjct: 1376 DATY-----EEQGPSPGYRMELS-----IFYVVYFVVFPFFFVNIFVALIIITF 1419
Score = 75.9 bits (185), Expect = 4e-13
Identities = 74/297 (24%), Positives = 124/297 (41%), Gaps = 68/297 (22%)
Query: 52 PFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFL 111
PFE I+ I N V L + D L L+ L F +FS+E +KIIA+G L
Sbjct: 1472 PFEYFIMAMIALNTVVLMMKF---YDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVL 1528
Query: 112 FHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLR 171
Y R WNV DF V LG T IL ++ +++ LR FR R
Sbjct: 1529 ----NYFRDAWNVFDFVTV-LGSITDIL---------VTEIAETNNFINLSFLRLFRAAR 1574
Query: 172 PLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGT 231
++L+ +++++L + ++ L ++ LL+ + IYAIIG+++F I
Sbjct: 1575 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGN--------IAL 1626
Query: 232 DIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITM 291
D ++ +F F +++ +++ T
Sbjct: 1627 DDDTSINRHN--------------------------------NFRTFLQALMLLFRSATG 1654
Query: 292 EGWTDVLYWV--NDAI---------GNEWPWIYFVTLILLGSFFILNLVLGVLSGEF 337
E W +++ N A G+++ + YFV+ I L SF +LNL + V+ F
Sbjct: 1655 EAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1711
Score = 64.7 bits (156), Expect = 8e-10
Identities = 67/307 (21%), Positives = 117/307 (38%), Gaps = 86/307 (28%)
Query: 1120 FEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVA---FTIIFTLEMILKLMA----F 1172
FEY++ A I+ N I L ++ + +S+ L+ F IF E +K++A F
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 1173 KARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISS 1232
Y + WNV DF++V+ I+ ++ D
Sbjct: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFDL---------------------------- 188
Query: 1233 AFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF--- 1289
R RV+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ +
Sbjct: 189 RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGK 248
Query: 1290 --------------------GKIA---LVDGTQINRN---------NNFQTFPQAVLLLF 1317
GK A L +G R NF A+L +F
Sbjct: 249 FHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
Query: 1318 RCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFV 1377
+C T E W +IL G + + YFI ++ +F ++NL +
Sbjct: 309 QCITMEGWTDILY----------------NTNDAAGNTWNWLYFIPLIIIGSFFMLNLVL 352
Query: 1378 AVIMDNF 1384
V+ F
Sbjct: 353 GVLSGEF 359
>gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E
subunit [Homo sapiens]
Length = 2270
Score = 729 bits (1882), Expect = 0.0
Identities = 395/874 (45%), Positives = 555/874 (63%), Gaps = 44/874 (5%)
Query: 684 RKMSKGLPDKSEEEKSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSADFPG 743
R +S+ PD S +T E IP L +D +++ D S
Sbjct: 1044 RVISQSEPDLSCITANTDKATTESTSVTVAIPDVDPL-VDSTVVHISNKTDGEASPLKEA 1102
Query: 744 DDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTN 803
+ EDE E+ + + + +E + SS FIFS TN IR CH IVN +F
Sbjct: 1103 EIREDEEEVEKKKQKK-----EKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEM 1157
Query: 804 FILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSF 863
ILL I SS ALAAEDP+ +S RN++L++FD FT VFT E+V+KM G L GS+
Sbjct: 1158 CILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSY 1217
Query: 864 CRNYFNMLDLLVVAVSLISMGLESSA-------ISVVKILRVLRVLRPLRAINRAKGLKH 916
R+ +N+LD +VV +L++ L ++ I +K LRVLRVLRPL+ I R LK
Sbjct: 1218 FRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKA 1277
Query: 917 VVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYK 976
V C+ ++ + NI++V L F+FA I VQLFKGKFF CTD SK TE+EC G Y
Sbjct: 1278 VFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYV--- 1334
Query: 977 DGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYN 1036
D + ++E++ REW +FH+DN++ A+++LFTVST EGWPQ+L ++D ED GP +
Sbjct: 1335 DHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRS 1394
Query: 1037 NRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKAR 1096
NR+EM+IF+++Y ++ FF +NIFV +I+TFQEQG+ + C L+KN+R C+ +A+ A+
Sbjct: 1395 NRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAK 1454
Query: 1097 PLRCYIPKN--PYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILN 1154
PL Y+P+N +QY+VW+ V S FEY + A+I LNT+ L M++Y+ LN
Sbjct: 1455 PLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLN 1514
Query: 1155 VAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYC 1214
+AFT++F+LE +LK++AF YF D WN+FDF+ VIGSI ++IL+ D+ L ++ G
Sbjct: 1515 IAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILT--DSKLVNTSGF-- 1570
Query: 1215 LGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLI 1274
+ +F +LFR RLIKLL + +R LLWTF++SF+ALPYV LLI
Sbjct: 1571 ----------------NMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLI 1614
Query: 1275 VMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSY 1334
MLFFIYA+IGMQ+FG I L + + INR+NNF++F +++LLFR ATGEAWQEI+L+C
Sbjct: 1615 AMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLG 1674
Query: 1335 GKLCDPESDYAPG--EEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWS 1392
K C+P++ G E CGT+ AY YF+SF C+FL++NLFVAVIMDNF+YLTRD S
Sbjct: 1675 EKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSS 1734
Query: 1393 ILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMN 1452
ILGPHHLDEF +WAEYD A GRI + ++ +L + PPLG GK CP +VA KRLV MN
Sbjct: 1735 ILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMN 1794
Query: 1453 MPLNSDGTVTFNATLFALVRTALKIKTE---GNFEQANEELRAIIKKIWKRTSMKLLDQV 1509
MP+ D TV F +TL AL+RTAL IK + +Q + EL+ IW S K+LD +
Sbjct: 1795 MPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLL 1854
Query: 1510 IPPIGDDEVTVGKFYATFLIQEHFRKF-MKRQEE 1542
+P ++TVGK YA +I +++++ +K+Q +
Sbjct: 1855 VPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQ 1888
Score = 607 bits (1566), Expect = e-173
Identities = 328/678 (48%), Positives = 433/678 (63%), Gaps = 50/678 (7%)
Query: 29 RALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEK 88
R+LF +N +RK +++W PFE +IL TI ANC+ LA+ +PEDD ++ LEK
Sbjct: 67 RSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEK 126
Query: 89 LEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSH 148
E +F+ +F EA +KI+A GF+FH+ +YLR+GWNV+DF +V G+ N
Sbjct: 127 TEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNT---- 182
Query: 149 TAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVI 208
+D++ LRA RVLRPL+LVSG+PSLQ+VL SI KAM+PL I LL+ F ++
Sbjct: 183 ---------HVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAIL 233
Query: 209 IYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGP 268
++AIIGLE + GK+H+ C+ + I+ + P PC G G EC+ W GP
Sbjct: 234 MFAIIGLEFYSGKLHRACFMNNSGILEGFD--PPHPCGVQGCPA-----GYECKD-WIGP 285
Query: 269 NHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNL 328
N GIT FDN F++LTV+QCITMEGWT VLY NDA+G W W+YF+ LI++GSFF+LNL
Sbjct: 286 NDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNL 345
Query: 329 VLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGE-VMDVEDFREGKLS 387
VLGVLSGEF KERE+ ++R F KLR +QQ++ +L GY +WI + E VM E+ + S
Sbjct: 346 VLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTS 405
Query: 388 LDE----------------GGSDTESLYEIAGL----------NKIIQFIRHWRQWNRIF 421
E S E +I+ + + + + ++R R+
Sbjct: 406 ALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLL 465
Query: 422 RWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLM 481
R +VKS+VFYW+V+ +VALNT +A HHNQP WLT L A + L LF EM +
Sbjct: 466 RISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSL 525
Query: 482 KMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKY 541
KMYG+G R YF S FN FD V I E++ T GISVLR +RLLRIFKITKY
Sbjct: 526 KMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKY 585
Query: 542 WTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFP 601
W SL NLV SL++S++SI SLL LLFLFIV+FALLGMQLFGGR++F D +NFD FP
Sbjct: 586 WASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFND-GTPSANFDTFP 644
Query: 602 QALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAV 661
A+++VFQ+LTGEDW +MYNGI + GG S GM IYFI+L + GNY LLNVFLAIAV
Sbjct: 645 AAIMTVFQILTGEDWNEVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAV 703
Query: 662 DNLAEAESLTSAQKAKAE 679
DNLA A+ LT ++ + E
Sbjct: 704 DNLANAQELTKDEQEEEE 721
Score = 208 bits (529), Expect = 5e-53
Identities = 173/685 (25%), Positives = 312/685 (45%), Gaps = 96/685 (14%)
Query: 8 DEGLRKKQPKKPVPEILPR--PPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANC 65
+E + KK+ KK E P ++F + NP+R+AC IV + FE ILL I A+
Sbjct: 1108 EEEVEKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASS 1167
Query: 66 VALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVL 125
+ALA P+ N+ N L +Y F VF+ E +K+I G + +Y R WN+L
Sbjct: 1168 IALAAEDPVLT--NSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNIL 1225
Query: 126 DFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLD-VKALRAFRVLRPLRLVSGVPSLQV 184
DF +V + L A ++KG + +K+LR RVLRPL+ + +P L+
Sbjct: 1226 DFVVVVGALVAFALAN--------ALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKA 1277
Query: 185 VLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSP 244
V + + ++ +F+I ++ + I+A+I ++LFKGK +F TD E E
Sbjct: 1278 VFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGK-----FFYCTDSSKDTEKE---- 1328
Query: 245 CARTGSGRRCTINGSECRG-GWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVND 303
C G+ N E +G W H+DN +++LT++ T EGW VL D
Sbjct: 1329 C--IGNYVDHEKNKMEVKGREWKRHEF---HYDNIIWALLTLFTVSTGEGWPQVLQHSVD 1383
Query: 304 AIGNE---------WPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLR 354
+ I++V ++ FF +N+ + ++ F ++ + K+
Sbjct: 1384 VTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGD---------KMM 1434
Query: 355 EKQQLDEDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFIRHW 414
E+ L+++ R + + + + R+
Sbjct: 1435 EECSLEKNERACIDFAISAKPL----------------------------------TRYM 1460
Query: 415 RQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSL 474
Q F+++ V S F + ++ ++ALNT+ + ++++ P N +
Sbjct: 1461 PQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMV 1520
Query: 475 FTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLG--ISVLRCIRL 532
F+ E ++K+ G YF +N FD V I EI+L +S + G +S L+ R
Sbjct: 1521 FSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRA 1580
Query: 533 LRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGG-RYDFEDTE 591
R+ K+ + ++ L+ + + S +++ + LL+ + I+A++GMQ+FG + D E
Sbjct: 1581 ARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHI 1640
Query: 592 VRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYG------GPSYPGM-------LVC 638
R +NF +F +L+ +F+ TGE W +M + + G PS L
Sbjct: 1641 NRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAY 1700
Query: 639 IYFIILFVCGNYILLNVFLAIAVDN 663
+YF+ ++++LN+F+A+ +DN
Sbjct: 1701 VYFVSFIFFCSFLMLNLFVAVIMDN 1725
Score = 135 bits (340), Expect = 4e-31
Identities = 153/716 (21%), Positives = 299/716 (41%), Gaps = 119/716 (16%)
Query: 434 FYWLVILIVALNTLSIASEHH---NQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGL-- 488
F ++++ + N + +A E H + ++R + + +F E +K+ LG
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
Query: 489 --RQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLS 546
Y + +N D VV SGIL T + + LR +R+LR K+ SL
Sbjct: 151 HKGSYLRNGWNVMDFIVVLSGILATAGTHFN--THVDLRTLRAVRVLRPLKLVSGIPSLQ 208
Query: 547 NLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGR---------------------- 584
++ S++ ++ + + LLLF I++FA++G++ + G+
Sbjct: 209 IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPC 268
Query: 585 --------YDFED---TEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYP 633
Y+ +D + FDN A+++VFQ +T E WT+++YN A G
Sbjct: 269 GVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWN- 327
Query: 634 GMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKGLP-- 691
+YFI L + G++ +LN+ L + A+ ++A + ++++++ + L
Sbjct: 328 ----WLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGY 383
Query: 692 ----DKSEEEKSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSADFPGDDEE 747
DK+EE L ++ K G L+ + + E D
Sbjct: 384 RAWIDKAEEVM------LAEENKNAGTSALEVLRRATIKRSRTEAMTR---------DSS 428
Query: 748 DEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILL 807
DE + +S PLA +K V + S+F +R+ +V + F +L
Sbjct: 429 DEHCVDISSVGTPLARASIKSAKV---DGVSYFRHKE-RLLRISIRHMVKSQVFYWIVLS 484
Query: 808 FILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNY 867
+ L++A +A + + + +L + + F +F +E+ LKM G L + +
Sbjct: 485 LVALNTACVAIVHHNQPQWLTH-LLYYAEFLFLGLFLLEMSLKMYGMGPRL----YFHSS 539
Query: 868 FNMLDLLVVAVSLISMG---LESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVA 924
FN D V S+ + + +LR LR+LR + L+++V + +
Sbjct: 540 FNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSS 599
Query: 925 ISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIE 984
+ +I +++ + L +FA +G+QLF G+F + DG P
Sbjct: 600 MKSIISLLFLLFLFIVVFALLGMQLFGGRF-------------------NFNDGTP---- 636
Query: 985 LRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIF 1044
+FD +A+M++F + T E W +++Y I S +++ AI+
Sbjct: 637 ---------SANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWS-----AIY 682
Query: 1045 FIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDK--NQRQCVQYALKARPL 1098
FI+ + + ++N+F+ + E E ++ NQ+ +Q A + P+
Sbjct: 683 FIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPM 738
Score = 110 bits (276), Expect = 1e-23
Identities = 74/282 (26%), Positives = 135/282 (47%), Gaps = 41/282 (14%)
Query: 1113 YIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAF 1172
++V S F +++ +L+ LNT C+ + H+NQ + + H+ F +F LEM LK+
Sbjct: 471 HMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGM 530
Query: 1173 KARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISS 1232
R YF +N FDF + +GSI +V+ + P S IS
Sbjct: 531 GPRLYFHSSFNCFDFGVTVGSIFEVVWAIF--------------------RPGTSFGIS- 569
Query: 1233 AFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GK 1291
R R++R+ K+ +R L+ + + S +++ + L+ + ++A++GMQ+F G+
Sbjct: 570 -VLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGR 628
Query: 1292 IALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYT 1351
DGT + NF TFP A++ +F+ TGE W E++ + +
Sbjct: 629 FNFNDGTP---SANFDTFPAAIMTVFQILTGEDWNEVMY------------NGIRSQGGV 673
Query: 1352 CGTNFAYYYFISFYMLCAFLVINLFVAVIMDNF---DYLTRD 1390
++ YFI + + ++N+F+A+ +DN LT+D
Sbjct: 674 SSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 715
Score = 107 bits (268), Expect = 8e-23
Identities = 83/321 (25%), Positives = 153/321 (47%), Gaps = 26/321 (8%)
Query: 778 SFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMR--NQILKHF 835
S FIF N +R ++++ F IL I+ + LA E + D ++ L+
Sbjct: 68 SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127
Query: 836 DIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISM-GLESSAISVVK 894
+ F +F E +K+ G HKGS+ RN +N++D +VV +++ G + ++
Sbjct: 128 EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLR 187
Query: 895 ILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKF 954
LR +RVLRPL+ ++ L+ V++ + A+ + I L+ MFA IG++ + GK
Sbjct: 188 TLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKL 247
Query: 955 FRCTDLSKMTEEECRGYYYVYKDGDPMQIE-----LRHREWVHSD---FHFDNVLSAMMS 1006
R ++ G + P ++ ++W+ + FDN+L A+++
Sbjct: 248 HRACFMNN------SGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLT 301
Query: 1007 LFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIV 1066
+F T EGW +LY D+ +G +N ++FI II+ +FF++N+ +G +
Sbjct: 302 VFQCITMEGWTTVLYNTNDA----LGATWN-----WLYFIPLIIIGSFFVLNLVLGVLSG 352
Query: 1067 TFQEQGETEYKNCELDKNQRQ 1087
F ++ E K +RQ
Sbjct: 353 EFAKERERVENRRAFMKLRRQ 373
Score = 90.9 bits (224), Expect = 1e-17
Identities = 80/307 (26%), Positives = 145/307 (47%), Gaps = 56/307 (18%)
Query: 422 RWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANR----VLLSLFTT 477
R CH IV + F ++L++A +++++A+E P+ ++ R V +FT
Sbjct: 1143 RRACHYIVNLRYFEMCILLVIAASSIALAAE---DPVLTNSERNKVLRYFDYVFTGVFTF 1199
Query: 478 EMLMKMYGLGL----RQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLG-----ISVLR 528
EM++KM GL YF ++N D FVV G L + + T G I LR
Sbjct: 1200 EMVIKMIDQGLILQDGSYFRDLWNILD-FVVVVGALVAFALANALGTNKGRDIKTIKSLR 1258
Query: 529 CIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDF- 587
+R+LR K K L + ++ S++++ ++L++ LF+ IFA++ +QLF G++ +
Sbjct: 1259 VLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYC 1318
Query: 588 ----EDTEV-----------------------RRSNFDNFPQALISVFQVLTGEDWTSMM 620
+DTE ++DN AL+++F V TGE W ++
Sbjct: 1319 TDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVL 1378
Query: 621 YNGIMAY---GGPSYPG-MLVCIYFIILFVCGNYILLNVFLAIAV-------DNLAEAES 669
+ + GPS M + I++++ FV + +N+F+A+ + D + E S
Sbjct: 1379 QHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECS 1438
Query: 670 LTSAQKA 676
L ++A
Sbjct: 1439 LEKNERA 1445
Score = 83.6 bits (205), Expect = 2e-15
Identities = 71/304 (23%), Positives = 129/304 (42%), Gaps = 76/304 (25%)
Query: 53 FETIILLTIFANCVALAV-YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFL 111
FE I+ I N V L + Y P + L L+ L F +VFS+E +K+IA+GFL
Sbjct: 1480 FEYTIMAMIALNTVVLMMKYYSAP----CTYELALKYLNIAFTMVFSLECVLKVIAFGFL 1535
Query: 112 FHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLR 171
Y R WN+ DF V + +IL ++ + +G ++ L+ FR R
Sbjct: 1536 ----NYFRDTWNIFDFITVIGSITEIILTDSKLVNT---------SGFNMSFLKLFRAAR 1582
Query: 172 PLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGT 231
++L+ +++++L + ++ L ++ LL+ + IYAIIG+++F
Sbjct: 1583 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF------------- 1629
Query: 232 DIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITM 291
++ +E S R + F +F S++ +++ T
Sbjct: 1630 ---GNIKLDEESHINRHNN------------------------FRSFFGSLMLLFRSATG 1662
Query: 292 EGWTDVLYWV------------------NDAIGNEWPWIYFVTLILLGSFFILNLVLGVL 333
E W +++ N+ G + ++YFV+ I SF +LNL + V+
Sbjct: 1663 EAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVI 1722
Query: 334 SGEF 337
F
Sbjct: 1723 MDNF 1726
Score = 67.4 bits (163), Expect = 1e-10
Identities = 68/304 (22%), Positives = 121/304 (39%), Gaps = 79/304 (25%)
Query: 1120 FEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVA---FTIIFTLEMILKLMA----F 1172
FEY++ A I+ N I L ++ + + +S L F IF E +K++A F
Sbjct: 91 FEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIF 150
Query: 1173 KARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISS 1232
Y + WNV DF++V+ I LA++G + + +
Sbjct: 151 HKGSYLRNGWNVMDFIVVLSGI-----------LATAGTHF-------------NTHVDL 186
Query: 1233 AFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GK 1291
R RV+R +KL+S ++ +L + +K+ L + LL+ ++A+IG++ + GK
Sbjct: 187 RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGK 246
Query: 1292 I---------ALVDGTQ-------------------INRNNNFQTFPQ---AVLLLFRCA 1320
+ +++G I N+ F AVL +F+C
Sbjct: 247 LHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCI 306
Query: 1321 TGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVI 1380
T E W +L G + + YFI ++ +F V+NL + V+
Sbjct: 307 TMEGWTTVLY----------------NTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVL 350
Query: 1381 MDNF 1384
F
Sbjct: 351 SGEF 354
>gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo
sapiens]
Length = 2506
Score = 729 bits (1881), Expect = 0.0
Identities = 380/825 (46%), Positives = 529/825 (64%), Gaps = 60/825 (7%)
Query: 728 NVNEVKDPYPSADFPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNK 787
N N DP P + +EE++ P+P +P SS FI S TN
Sbjct: 1186 NKNANPDPLPKKEEEKKEEEEDDRGEDGPKP--------------MPPYSSMFILSTTNP 1231
Query: 788 IRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEI 847
+R LCH I+N +F IL+ I +SS ALAAEDP++ ++ RN +L++FD FT VFT E+
Sbjct: 1232 LRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEM 1291
Query: 848 VLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSA----ISVVKILRVLRVLR 903
V+KM G LH+G++ R+ +N+LD +VV+ +L++ ++ I+ +K LRVLRVLR
Sbjct: 1292 VIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLR 1351
Query: 904 PLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKM 963
PL+ I R LK V C+ ++ + NI++V L F+FA + VQLFKGKFF CTD SK
Sbjct: 1352 PLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKE 1411
Query: 964 TEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKA 1023
E++CRG Y +Y+ + ++ R REW +FH+DNVL A+++LFTVST EGWPQ+L +
Sbjct: 1412 FEKDCRGKYLLYEKNE---VKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHS 1468
Query: 1024 IDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDK 1083
+D+ E+ GP R+EM+IF+++Y ++ FF +NIFV +I+TFQEQG+ + L+K
Sbjct: 1469 VDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEK 1528
Query: 1084 NQRQCVQYALKARPLRCYIPKNP--YQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYN 1141
N+R C+ +A+ A+PL ++P+N +QY++W V S FEY + A+I LNTI L M+ Y
Sbjct: 1529 NERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYG 1588
Query: 1142 QSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSE 1201
S + + N+ FT +F+LE +LK+MAF YF D WN+FDF+ V+GSI D++++E
Sbjct: 1589 ASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTE 1648
Query: 1202 IDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFI 1261
I+ +F RLFR RLIKLL + +R LLWTF+
Sbjct: 1649 FGNNF-----------------------INLSFLRLFRAARLIKLLRQGYTIRILLWTFV 1685
Query: 1262 KSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL--------VDGTQINRNNNFQTFPQAV 1313
+SF+ALPYV LLI MLFFIYA+IGMQ+FG I + D QI +NNF+TF QA+
Sbjct: 1686 QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQAL 1745
Query: 1314 LLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVI 1373
+LLFR ATGEAW I+L+C GK CD S E CG FAY+YF+SF LC+FL++
Sbjct: 1746 MLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRE---CGNEFAYFYFVSFIFLCSFLML 1802
Query: 1374 NLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPL 1433
NLFVAVIMDNF+YLTRD SILGPHHLDE+ +WAEYDP A GR+ +LD+ +LR + PPL
Sbjct: 1803 NLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPL 1862
Query: 1434 GFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTE---GNFEQANEEL 1490
G GK CP RVA KRL+ M++P+ D TV FN+TL AL+RTAL IK + +Q + EL
Sbjct: 1863 GLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAEL 1922
Query: 1491 RAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRK 1535
R + IW S K LD ++ P ++TVGK YA +I E++R+
Sbjct: 1923 RKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQ 1967
Score = 628 bits (1620), Expect = e-179
Identities = 338/715 (47%), Positives = 457/715 (63%), Gaps = 54/715 (7%)
Query: 29 RALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEK 88
R+LF + +N +RK I EW PFE +IL TI ANC+ LA+ +P+DD ++ L+
Sbjct: 76 RSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDD 135
Query: 89 LEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSH 148
E +F+ +F EA +KIIA GF FH+ +YLR+GWNV+DF +V G+ +
Sbjct: 136 TEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATV---------- 185
Query: 149 TAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVI 208
G D++ LRA RVLRPL+LVSG+PSLQVVL SI KAM+PL I LL+ F ++
Sbjct: 186 -------GTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAIL 238
Query: 209 IYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGP 268
I+AIIGLE + GK H TC+ GTD ++ E P+PC R C NG++C+ W GP
Sbjct: 239 IFAIIGLEFYMGKFHTTCFEEGTD---DIQGESPAPCGTEEPARTCP-NGTKCQPYWEGP 294
Query: 269 NHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNL 328
N+GIT FDN F++LTV+QCITMEGWTD+LY NDA GN W W+YF+ LI++GSFF+LNL
Sbjct: 295 NNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNL 354
Query: 329 VLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQG-EVMDVEDFREG--- 384
VLGVLSGEF KERE+ ++R F KLR +QQ++ +L GYM WI++ EV+ ED +G
Sbjct: 355 VLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQR 414
Query: 385 --------------KLSLDEGGSDTESLYEIAGL----------NKIIQFIRHWRQWNRI 420
K L + L +IA + + ++ + + R
Sbjct: 415 HPFDALRRTTIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERR 474
Query: 421 FRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEML 480
R+ +VK++ FYW V+ +VALNTL +A H+NQP WL+ A + L LF +EM
Sbjct: 475 MRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMF 534
Query: 481 MKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITK 540
+KMYGLG R YF S FN FDC V+ I E++ T GISVLR +RLLRIFK+TK
Sbjct: 535 IKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTK 594
Query: 541 YWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNF 600
YW SL NLV SLLNS++SI SLL LLFLFIV+FALLGMQLFGG+++F D +NFD F
Sbjct: 595 YWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF-DEGTPPTNFDTF 653
Query: 601 PQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIA 660
P A+++VFQ+LTGEDW +MY+GI + GG GM+ IYFI+L + GNY LLNVFLAIA
Sbjct: 654 PAAIMTVFQILTGEDWNEVMYDGIKSQGGVQ-GGMVFSIYFIVLTLFGNYTLLNVFLAIA 712
Query: 661 VDNLAEAESLTSAQKAK---AEEKKRRKMSKGLPDKSEEEKSTMAKKLEQKPKGE 712
VDNLA A+ LT ++ + A +K + +K + + S + M+ ++++ K +
Sbjct: 713 VDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQ 767
Score = 221 bits (562), Expect = 7e-57
Identities = 176/690 (25%), Positives = 323/690 (46%), Gaps = 104/690 (15%)
Query: 2 EPSSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTI 61
E ++E R + KP+P P ++F L+ NPLR+ C I+ + FE IL+ I
Sbjct: 1199 EEKKEEEEDDRGEDGPKPMP-----PYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVI 1253
Query: 62 FANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSG 121
+ +ALA P+ N N L +Y F VF+ E +K+I G + HQ AY R
Sbjct: 1254 AMSSIALAAEDPV--QPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDL 1311
Query: 122 WNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLD-VKALRAFRVLRPLRLVSGVP 180
WN+LDF +V + + +SKG ++ +K+LR RVLRPL+ + +P
Sbjct: 1312 WNILDFIVVS-----------GALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLP 1360
Query: 181 SLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENE 240
L+ V + + ++ +F+I ++ + + I+A++ ++LFKGK +F TD E++
Sbjct: 1361 KLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGK-----FFHCTD-----ESK 1410
Query: 241 EPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVL-Y 299
E R G+ +E + H+DN +++LT++ T EGW VL +
Sbjct: 1411 EFEKDCR---GKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKH 1467
Query: 300 WVNDAIGNEWP--------WIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQ 351
V+ N+ P I++V ++ FF +N+ + ++ F ++ +
Sbjct: 1468 SVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGD--------- 1518
Query: 352 KLREKQQLDEDLRGYMSWITQGEVMDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFI 411
K+ E+ L+++ R + + + +
Sbjct: 1519 KMMEEYSLEKNERACIDFAISAKPL----------------------------------T 1544
Query: 412 RHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVL 471
RH Q + F+++ V S F + ++ ++ALNT+ + + + + + N V
Sbjct: 1545 RHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVF 1604
Query: 472 LSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIR 531
SLF+ E ++K+ G+ YF +N FD V I +IL+ E G + +S LR R
Sbjct: 1605 TSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFG-NNFINLSFLRLFR 1663
Query: 532 LLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGG-RYDFEDT 590
R+ K+ + ++ L+ + + S +++ + LL+ + I+A++GMQ+FG D ED
Sbjct: 1664 AARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDE 1723
Query: 591 E--------VRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGML------ 636
+ +NF F QAL+ +F+ TGE W ++M + + G+L
Sbjct: 1724 DSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGN 1783
Query: 637 --VCIYFI-ILFVCGNYILLNVFLAIAVDN 663
YF+ +F+C ++++LN+F+A+ +DN
Sbjct: 1784 EFAYFYFVSFIFLC-SFLMLNLFVAVIMDN 1812
Score = 127 bits (318), Expect = 1e-28
Identities = 151/704 (21%), Positives = 297/704 (42%), Gaps = 122/704 (17%)
Query: 434 FYWLVILIVALNTLSIASEHH---NQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLR- 489
F ++++ + N + +A E H + ++ D + +F E +K+ LG
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 490 ---QYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLS 546
Y + +N D VV +GIL + E T LR +R+LR K+ SL
Sbjct: 160 HKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT------LRAVRVLRPLKLVSGIPSLQ 213
Query: 547 NLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYD---FED-------------- 589
++ S++ ++ + + LLLF I+IFA++G++ + G++ FE+
Sbjct: 214 VVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCG 273
Query: 590 -TEVRRS-------------------NFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGG 629
E R+ FDN A+++VFQ +T E WT ++YN A G
Sbjct: 274 TEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGN 333
Query: 630 PSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKG 689
+YFI L + G++ +LN+ L + A+ ++A + ++++++ +
Sbjct: 334 TWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388
Query: 690 LPDKSEE-EKSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSADFPGDDEED 748
L E K+ E + GE L+ + + ++ +P +E +
Sbjct: 389 LNGYMEWISKAEEVILAEDETDGEQRHPFDALRRTTIKKSKTDLLNP---------EEAE 439
Query: 749 EPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLF 808
+ ++ P A +K + E S+FF ++R R+V F +L
Sbjct: 440 DQLADIASVGSPFARASIKSAKL---ENSTFF-HKKERRMRFYIRRMVKTQAFYWTVLSL 495
Query: 809 ILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYF 868
+ L++ +A + + + + L + + F +F E+ +KM YG L + + F
Sbjct: 496 VALNTLCVAIVHYNQPEWL-SDFLYYAEFIFLGLFMSEMFIKM--YG--LGTRPYFHSSF 550
Query: 869 NMLDLLVVAVSLISM---GLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAI 925
N D V+ S+ + ++ + +LR LR+LR + L+++V + ++
Sbjct: 551 NCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSM 610
Query: 926 STIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIEL 985
+I +++ + L +FA +G+QLF G+F + +G P
Sbjct: 611 KSIISLLFLLFLFIVVFALLGMQLFGGQFN-------------------FDEGTPPT--- 648
Query: 986 RHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFF 1045
+FD +A+M++F + T E W +++Y I S G + V +I+F
Sbjct: 649 ----------NFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQ----GGVQGGMV-FSIYF 693
Query: 1046 IIYIILIAFFMMNIFVGFVI--------VTFQEQGETEYKNCEL 1081
I+ + + ++N+F+ + +T EQ E E N +L
Sbjct: 694 IVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKL 737
Score = 108 bits (270), Expect = 5e-23
Identities = 80/301 (26%), Positives = 138/301 (45%), Gaps = 50/301 (16%)
Query: 1094 KARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDIL 1153
K R +R YI + +V + F + + +L+ LNT+C+ + HYNQ E ++
Sbjct: 471 KERRMRFYIRR---------MVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYA 521
Query: 1154 NVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLY 1213
F +F EM +K+ R YF +N FD ++IGSI +VI + I
Sbjct: 522 EFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVI----------- 570
Query: 1214 CLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALL 1273
P S IS R R++R+ K+ +R L+ + + S +++ + L
Sbjct: 571 ---------KPGTSFGIS--VLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFL 619
Query: 1274 IVMLFFIYAVIGMQMF-GKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLAC 1332
+ + ++A++GMQ+F G+ +GT NF TFP A++ +F+ TGE W E++
Sbjct: 620 LFLFIVVFALLGMQLFGGQFNFDEGTP---PTNFDTFPAAIMTVFQILTGEDWNEVMY-- 674
Query: 1333 SYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNF---DYLTR 1389
D + G YFI + + ++N+F+A+ +DN LT+
Sbjct: 675 ----------DGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK 724
Query: 1390 D 1390
D
Sbjct: 725 D 725
Score = 102 bits (253), Expect = 5e-21
Identities = 86/326 (26%), Positives = 154/326 (47%), Gaps = 23/326 (7%)
Query: 778 SFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMR--NQILKHF 835
S F+FS N +R +I F IL I+ + LA E + D ++ L
Sbjct: 77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136
Query: 836 DIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLI-SMGLESSAISVVK 894
+ F +F E +K+ G HKGS+ RN +N++D +VV ++ ++G E ++
Sbjct: 137 EPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD----LR 192
Query: 895 ILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKF 954
LR +RVLRPL+ ++ L+ V++ + A+ + I L+ +FA IG++ + GKF
Sbjct: 193 TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKF 252
Query: 955 FR------CTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLF 1008
D+ + C + + + + FDN+L A++++F
Sbjct: 253 HTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVF 312
Query: 1009 TVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTF 1068
T EGW LLY + D++ G +N ++FI II+ +FFM+N+ +G + F
Sbjct: 313 QCITMEGWTDLLYNSNDAS----GNTWN-----WLYFIPLIIIGSFFMLNLVLGVLSGEF 363
Query: 1069 -QEQGETEYKNCELDKNQRQCVQYAL 1093
+E+ E + L ++Q ++ L
Sbjct: 364 AKERERVENRRAFLKLRRQQQIEREL 389
Score = 99.4 bits (246), Expect = 3e-20
Identities = 80/300 (26%), Positives = 152/300 (50%), Gaps = 51/300 (17%)
Query: 425 CHDIVKSKVFYWLVILIVALNTLSIASEHHNQP-LWLTRLQDIANRVLLSLFTTEMLMKM 483
CH I+ + F +++++A++++++A+E QP + + V +FT EM++KM
Sbjct: 1236 CHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKM 1295
Query: 484 YGLGL----RQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKIT 539
LGL YF ++N D F+V SG L + +G I+ ++ +R+LR+ +
Sbjct: 1296 IDLGLVLHQGAYFRDLWNILD-FIVVSGAL-VAFAFTGNSKGKDINTIKSLRVLRVLRPL 1353
Query: 540 KYWTSLSNLVA---SLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYD---------- 586
K L L A ++NS++++ ++L++ LF+ IFA++ +QLF G++
Sbjct: 1354 KTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFE 1413
Query: 587 ---------FEDTEVR---------RSNFDNFPQALISVFQVLTGEDWTSMMYNGIMA-- 626
+E EV+ ++DN AL+++F V TGE W ++ + + A
Sbjct: 1414 KDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1473
Query: 627 -YGGPSYPG--MLVCIYFIILFVCGNYILLNVFLAIAV-------DNLAEAESLTSAQKA 676
GPS PG M + I++++ FV + +N+F+A+ + D + E SL ++A
Sbjct: 1474 ENQGPS-PGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERA 1532
Score = 75.1 bits (183), Expect = 6e-13
Identities = 71/322 (22%), Positives = 129/322 (40%), Gaps = 69/322 (21%)
Query: 34 LTLENPLRKACISIVEWK-----PFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEK 88
LT P K W+ PFE I+ I N + L + + + L
Sbjct: 1543 LTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKF---YGASVAYENALRV 1599
Query: 89 LEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSH 148
F +FS+E +K++A+G L Y R WN+ DF V + +++ +
Sbjct: 1600 FNIVFTSLFSLECVLKVMAFGIL----NYFRDAWNIFDFVTVLGSITDILVTEFG----- 1650
Query: 149 TAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVI 208
+++ LR FR R ++L+ +++++L + ++ L ++ LL+ +
Sbjct: 1651 -------NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF 1703
Query: 209 IYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGP 268
IYAIIG+++F IG D+ +E+ +
Sbjct: 1704 IYAIIGMQVFGN--------IGIDVEDEDSDEDEFQITEHNN------------------ 1737
Query: 269 NHGITHFDNFGFSMLTVYQCITMEGWTDVLYWV--------NDAI-----GNEWPWIYFV 315
F F +++ +++ T E W +++ N I GNE+ + YFV
Sbjct: 1738 ------FRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFV 1791
Query: 316 TLILLGSFFILNLVLGVLSGEF 337
+ I L SF +LNL + V+ F
Sbjct: 1792 SFIFLCSFLMLNLFVAVIMDNF 1813
Score = 67.4 bits (163), Expect = 1e-10
Identities = 68/308 (22%), Positives = 119/308 (38%), Gaps = 87/308 (28%)
Query: 1120 FEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVA---FTIIFTLEMILKLMA----F 1172
FEY++ A I+ N I L ++ + + +S+ L+ F IF E +K++A F
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 1173 KARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISS 1232
Y + WNV DF++V+ I+ + +E D
Sbjct: 160 HKGSYLRNGWNVMDFVVVLTGILATVGTEFDL---------------------------- 191
Query: 1233 AFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GK 1291
R RV+R +KL+S ++ +L + +K+ L + LL+ I+A+IG++ + GK
Sbjct: 192 RTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGK 251
Query: 1292 I---------------------------ALVDGTQI-----NRNNNFQTFPQ---AVLLL 1316
+GT+ NN F AVL +
Sbjct: 252 FHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTV 311
Query: 1317 FRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLF 1376
F+C T E W ++L G + + YFI ++ +F ++NL
Sbjct: 312 FQCITMEGWTDLLY----------------NSNDASGNTWNWLYFIPLIIIGSFFMLNLV 355
Query: 1377 VAVIMDNF 1384
+ V+ F
Sbjct: 356 LGVLSGEF 363
>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
sapiens]
Length = 1977
Score = 427 bits (1098), Expect = e-119
Identities = 351/1187 (29%), Positives = 566/1187 (47%), Gaps = 172/1187 (14%)
Query: 409 QFIRHWRQWNRIFRW----KCHDIVKSKVFYWLVILI-VALNTLSIASEHHNQPLWLTRL 463
+F + WN W KC + F L I I + LNTL +A EHH +
Sbjct: 705 RFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNV 764
Query: 464 QDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLG 523
I N V +F EM++K+ + +YF +N FD +V ++E+ L + G
Sbjct: 765 LAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVE-----G 819
Query: 524 ISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGG 583
+SVLR RLLR+FK+ K W +L+ L+ + NS+ ++ +L L+L + + IFA++GMQLFG
Sbjct: 820 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 879
Query: 584 RYDF------EDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLV 637
Y +D + R + ++F + + VF+VL GE W M++ + G M +
Sbjct: 880 SYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAG----QAMCL 934
Query: 638 CIYFIILFVCGNYILLNVFLAIAV-----DNLAEAE----------SLTSAQKA------ 676
+Y +++ V GN ++LN+FLA+ + DNL E ++T +K
Sbjct: 935 IVYMMVM-VIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQ 993
Query: 677 -------KAEEKKRR-------------------------KMSKGLPDKSEEEK-----S 699
KA KK + +MSKG E++K S
Sbjct: 994 TLREFILKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGS 1053
Query: 700 TMAKKLEQKPKGEGI----PTTAKLKIDEFESNVNEVKDPYPSAD--------------- 740
++ K L + G+ T + I ES++ + S+D
Sbjct: 1054 SVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSS 1113
Query: 741 ---------FPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKI--- 788
PG+ EE E E S P E + V I S KI
Sbjct: 1114 SECSTVDNPLPGEGEEAEAEPMNSDEP----EACFTDGCVRRFSCCQVNIESGKGKIWWN 1169
Query: 789 -RVLCHRIVNATWFTNFILLFILLSSAALAAEDP-IRADSMRNQILKHFDIGFTSVFTVE 846
R C++IV +WF +FI+L ILLSS ALA ED I IL++ D FT +F +E
Sbjct: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILE 1229
Query: 847 IVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISM---GLESSAISVVKILRVLRVLR 903
++LK YG ++ N + LD L+V VSL+++ L S + +K LR LR LR
Sbjct: 1230 MLLKWIAYGY----KTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALR 1285
Query: 904 PLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRC---TDL 960
PLRA++R +G++ VV + AI +I N++LV + +F+ +GV LF GKF+ C TD
Sbjct: 1286 PLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDG 1345
Query: 961 SKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLL 1020
S+ + + + Q + W + +FDNV +SL V+TF+GW ++
Sbjct: 1346 SRFPASQVPNRSECFALMNVSQ----NVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIM 1401
Query: 1021 YKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQ-----GETE 1075
Y A+DS D P Y + M I+F+++II +FF +N+F+G +I F +Q G+
Sbjct: 1402 YAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1461
Query: 1076 YKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICL 1135
+ E K + K P N Q ++ +VT+ F+ + LI LN + +
Sbjct: 1462 FMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTM 1521
Query: 1136 GMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSII 1195
++ QS+ M + +NV F I+FT E +LKL++ + YF WN+FDF++VI SI+
Sbjct: 1522 MVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR-HYYFTVGWNIFDFVVVIISIV 1580
Query: 1196 DVILSE-IDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVR 1254
+ L++ I+T+ S RL R+ R+++L+ A+G+R
Sbjct: 1581 GMFLADLIETYFVSP--------------------TLFRVIRLARIGRILRLVKGAKGIR 1620
Query: 1255 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVL 1314
TLL+ + S AL + LL+ ++ FIYA+ GM F + DG IN NF+TF +++
Sbjct: 1621 TLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDG--INDMFNFETFGNSMI 1678
Query: 1315 LLFRCATGEAWQEILLACSYGKL--CDPESDYAPGE--EYTCGT-NFAYYYFISFYMLCA 1369
LF+ T W +L K CDP+ + PG E CG + +YF+S+ ++
Sbjct: 1679 CLFQITTSAGWDGLLAPILNSKPPDCDPKKVH-PGSSVEGDCGNPSVGIFYFVSYIIISF 1737
Query: 1370 FLVINLFVAVIMDNFDYLTRD-WSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRR 1428
+V+N+++AVI++NF T + L + F +W ++DP+A I+ +
Sbjct: 1738 LVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAA 1797
Query: 1429 IQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTAL 1475
+ PPL K P++V +L+ M++P+ S + LFA + L
Sbjct: 1798 LDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFAFTKRVL 1839
Score = 191 bits (485), Expect = 6e-48
Identities = 169/672 (25%), Positives = 303/672 (45%), Gaps = 130/672 (19%)
Query: 40 LRKACISIVEWKPFETIILLTIFANCVALA---VYLPMPEDDNNSLNLGLEKLEYFFLIV 96
+RK C IVE FE+ I+L I + ALA +Y+ + ++ + LE + F +
Sbjct: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYI----ERKKTIKIILEYADKIFTYI 1225
Query: 97 FSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKG 156
F +E +K IAYG+ Y + W LDF IV + + T++ ++T S G
Sbjct: 1226 FILEMLLKWIAYGY----KTYFTNAWCWLDFLIVDVSLVTLV--------ANTLGYSDLG 1273
Query: 157 AGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLE 216
+K+LR R LRPLR +S ++VV+N++ A+ + ++ L+ L +I++I+G+
Sbjct: 1274 P---IKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVN 1330
Query: 217 LFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTI----NGSEC--------RGG 264
LF GK ++ C T G R N SEC
Sbjct: 1331 LFAGKFYE--------------------CINTTDGSRFPASQVPNRSECFALMNVSQNVR 1370
Query: 265 WPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNE---------WPWIYFV 315
W +FDN G L++ Q T +GWT ++Y D++ + + +IYFV
Sbjct: 1371 WKNLK---VNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFV 1427
Query: 316 TLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEV 375
I+ GSFF LNL +GV+ F ++++K + F +K+ +
Sbjct: 1428 VFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYN--------------A 1473
Query: 376 MDVEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFIRHWRQWNRIFRWKCHDIVKSKVFY 435
M ++ + + G NKI I D+V ++ F
Sbjct: 1474 MKKLGSKKPQKPIPRPG------------NKIQGCI--------------FDLVTNQAFD 1507
Query: 436 WLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSI 495
+++++ LN +++ E Q +T + N V + LFT E ++K+ + LR Y+ ++
Sbjct: 1508 ISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKL--ISLRHYYFTV 1565
Query: 496 -FNRFDCFVVCSGILEIL---LVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVAS 551
+N FD VV I+ + L+E+ ++P V+R R+ RI ++ K + L+ +
Sbjct: 1566 GWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFA 1625
Query: 552 LLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVL 611
L+ S+ ++ ++ LLLFL + I+A+ GM F ED NF+ F ++I +FQ+
Sbjct: 1626 LMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKKEDGINDMFNFETFGNSMICLFQIT 1684
Query: 612 TGEDWTSMM----------------YNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNV 655
T W ++ + G G P + + YF+ + +++N+
Sbjct: 1685 TSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGI-FYFVSYIIISFLVVVNM 1743
Query: 656 FLAIAVDNLAEA 667
++A+ ++N + A
Sbjct: 1744 YIAVILENFSVA 1755
Score = 146 bits (368), Expect = 2e-34
Identities = 102/356 (28%), Positives = 181/356 (50%), Gaps = 50/356 (14%)
Query: 30 ALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKL 89
AL+ L+ +PLR+ I I+ F +I+ TI NC+ + + P P+ N +
Sbjct: 105 ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP-PDWTKN--------V 155
Query: 90 EYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHT 149
EY F +++ E+ +KI+A GF + +LR WN LDF ++ VF + E VN+
Sbjct: 156 EYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVI---VFAYLTEFVNLG---- 208
Query: 150 APMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVII 209
+V ALR FRVLR L+ +S +P L+ ++ ++ +++ L + +L +F + +
Sbjct: 209 ----------NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 258
Query: 210 YAIIGLELFKGKMHKTCYFIGTD-------IVATVENEEPSP--------------CART 248
+A+IGL+LF G + C+ + I+ T+E+EE C +
Sbjct: 259 FALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFS 318
Query: 249 GSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNE 308
+C G C P++G T FD F ++ L +++ +T + W ++ A G
Sbjct: 319 TDSGQCP-EGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKT 377
Query: 309 WPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLR 364
+ I+FV +I LGSF+++NL+L V++ + +E+ +A QK E QQ+ + L+
Sbjct: 378 Y-MIFFVVVIFLGSFYLINLILAVVAMAY-EEQNQANIEEAKQKELEFQQMLDRLK 431
Score = 102 bits (254), Expect = 4e-21
Identities = 80/314 (25%), Positives = 148/314 (47%), Gaps = 53/314 (16%)
Query: 1080 ELDKNQRQC----VQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICL 1135
EL++++++C ++A K C ++ +++IV + + + I+LNT+ +
Sbjct: 691 ELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFM 750
Query: 1136 GMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSII 1195
M+H+ +E+ ++ I N+ FT IF EM+LKL+A YF WN+FD LIV S++
Sbjct: 751 AMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLV 810
Query: 1196 DVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRT 1255
++ L++++ GL L R FR++R+ KL +
Sbjct: 811 ELFLADVE-------GLSVL--------------------RSFRLLRVFKLAKSWPTLNM 843
Query: 1256 LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNN-----NFQTFP 1310
L+ S AL + L++ ++ FI+AV+GMQ+FGK +IN + + F
Sbjct: 844 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFF 903
Query: 1311 QAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAF 1370
+ L++FR GE W E + C G ++ ++
Sbjct: 904 HSFLIVFRVLCGE-WIETMWDCM----------------EVAGQAMCLIVYMMVMVIGNL 946
Query: 1371 LVINLFVAVIMDNF 1384
+V+NLF+A+++ +F
Sbjct: 947 VVLNLFLALLLSSF 960
Score = 89.4 bits (220), Expect = 3e-17
Identities = 82/344 (23%), Positives = 159/344 (46%), Gaps = 59/344 (17%)
Query: 778 SFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDI 837
+ ++ SP + +R + +I+ + F+ I+ IL + + +P K+ +
Sbjct: 105 ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP-------PDWTKNVEY 157
Query: 838 GFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILR 897
FT ++T E ++K+ G + + +F R+ +N LD +V+ + ++ E + V LR
Sbjct: 158 TFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLT---EFVNLGNVSALR 214
Query: 898 VLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKG----K 953
RVLR L+ I+ GLK +V + ++ + +++++T +FA IG+QLF G K
Sbjct: 215 TFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHK 274
Query: 954 FFRCTDLSKMT----------EEECRGYYYVYKDGDPMQIEL------------------ 985
FR + + T EE+ R Y+Y Y +G +
Sbjct: 275 CFRNSLENNETLESIMNTLESEEDFRKYFY-YLEGSKDALLCGFSTDSGQCPEGYTCVKI 333
Query: 986 -RHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIF 1044
R+ ++ ++ FD A ++LF + T + W L + + + G Y IF
Sbjct: 334 GRNPDYGYTS--FDTFSWAFLALFRLMTQDYWENLYQQTLRA----AGKTY------MIF 381
Query: 1045 FIIYIILIAFFMMNIFVGFVIVTFQEQGET---EYKNCELDKNQ 1085
F++ I L +F+++N+ + V + ++EQ + E K EL+ Q
Sbjct: 382 FVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQ 425
Score = 86.3 bits (212), Expect = 3e-16
Identities = 76/301 (25%), Positives = 133/301 (44%), Gaps = 62/301 (20%)
Query: 42 KACISIVEWKPF-ETIILLTIFANCVALAV-YLPMPEDDNNSLNLGLEKLEYFFLIVFSI 99
K CI + PF + I + I N + +A+ + PM E+ N L +G F +F+
Sbjct: 723 KKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIG----NLVFTGIFAA 778
Query: 100 EAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGL 159
E +K+IA Y + GWN+ D IV L + + L V GL
Sbjct: 779 EMVLKLIA----MDPYEYFQVGWNIFDSLIVTLSLVELFLADVE--------------GL 820
Query: 160 DVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFK 219
V LR+FR+LR +L P+L +++ I ++ L ++ L++ +V I+A++G++LF
Sbjct: 821 SV--LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF- 877
Query: 220 GKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFG 279
GK +K C C IN W H ++F
Sbjct: 878 GKSYKECV--------------------------CKINDDCTLPRW--------HMNDFF 903
Query: 280 FSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTK 339
S L V++ + E W + ++ + G I ++ ++++G+ +LNL L +L F+
Sbjct: 904 HSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSS 962
Query: 340 E 340
+
Sbjct: 963 D 963
Score = 75.1 bits (183), Expect = 6e-13
Identities = 86/383 (22%), Positives = 158/383 (41%), Gaps = 95/383 (24%)
Query: 11 LRKKQPKKPVPEILPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAV 70
L K+P+KP+P RP N ++ +V + F+ I++ I N V + V
Sbjct: 1477 LGSKKPQKPIP----RPG---------NKIQGCIFDLVTNQAFDISIMVLICLNMVTMMV 1523
Query: 71 YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIV 130
E + + L + F+I+F+ E +K+I+ + Y GWN+ DF +V
Sbjct: 1524 E---KEGQSQHMTEVLYWINVVFIILFTGECVLKLISL-----RHYYFTVGWNIFDFVVV 1575
Query: 131 FLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIF 190
+ + + L ++I+++ + + +R R+ R LRLV G ++ +L ++
Sbjct: 1576 IISIVGMFL--ADLIETYFVSPTL------FRVIRLARIGRILRLVKGAKGIRTLLFALM 1627
Query: 191 KAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGS 250
++ LF+I LL+ ++ IYAI G+ F A V+ E+
Sbjct: 1628 MSLPALFNIGLLLFLVMFIYAIFGMSNF----------------AYVKKED--------- 1662
Query: 251 GRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVL------------ 298
G N + +F+ FG SM+ ++Q T GW +L
Sbjct: 1663 ----------------GIN-DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCD 1705
Query: 299 -------YWVNDAIGNEWPWI-YFVTLILLGSFFILNLVLGVLSGEF---TKEREKAKSR 347
V GN I YFV+ I++ ++N+ + V+ F T+E + S
Sbjct: 1706 PKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSE 1765
Query: 348 GTFQKLREK-QQLDEDLRGYMSW 369
F+ E ++ D D ++ +
Sbjct: 1766 DDFEMFYEVWEKFDPDATQFIEF 1788
Score = 60.1 bits (144), Expect = 2e-08
Identities = 75/334 (22%), Positives = 126/334 (37%), Gaps = 121/334 (36%)
Query: 1114 IVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFK 1173
I+ S F L+ I+ N C+ M N + ++ FT I+T E ++K++A
Sbjct: 122 ILVHSLFSMLIMCTILTN--CIFMTMNNPPDWTKNVE----YTFTGIYTFESLVKILA-- 173
Query: 1174 ARGY-------FGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDE 1226
RG+ DPWN DF++++ + + ++ GNV
Sbjct: 174 -RGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVN------------------LGNVSA-- 212
Query: 1227 SARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGM 1286
R FRV+R +K +S G++T++ I+S + L V +L V ++A+IG+
Sbjct: 213 --------LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGL 264
Query: 1287 QMF-----------------------------------------GKIALVDG-------- 1297
Q+F K AL+ G
Sbjct: 265 QLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQC 324
Query: 1298 ------TQINRN-----NNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAP 1346
+I RN +F TF A L LFR T + W+ + ++ A
Sbjct: 325 PEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLY----------QQTLRAA 374
Query: 1347 GEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVI 1380
G+ Y +F+ L +F +INL +AV+
Sbjct: 375 GKTY-------MIFFVVVIFLGSFYLINLILAVV 401
Score = 55.1 bits (131), Expect = 6e-07
Identities = 70/338 (20%), Positives = 133/338 (39%), Gaps = 72/338 (21%)
Query: 428 IVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKM---- 483
I+ +F L++ + N + + +N P W ++ ++T E L+K+
Sbjct: 122 ILVHSLFSMLIMCTILTNCIFMTM--NNPPDWTKNVE----YTFTGIYTFESLVKILARG 175
Query: 484 YGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWT 543
+ +G + +N D V+ L V G +S LR R+LR K
Sbjct: 176 FCVGEFTFLRDPWNWLDFVVIVFAYLTEF-VNLG-----NVSALRTFRVLRALKTISVIP 229
Query: 544 SLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGG-------RYDFEDTEVRRS- 595
L +V +L+ S++ ++ +++L + +FAL+G+QLF G R E+ E S
Sbjct: 230 GLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESI 289
Query: 596 ---------------NFDNFPQALISVFQVLTG---EDWTSMMYNGIMAYGGPSY----- 632
+ AL+ F +G E +T + YG S+
Sbjct: 290 MNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSW 349
Query: 633 ------------------------PGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAE 668
G I+F+++ G++ L+N+ LA+ V E +
Sbjct: 350 AFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAV-VAMAYEEQ 408
Query: 669 SLTSAQKAKAEEKKRRKMSKGLPDKSEEEKSTMAKKLE 706
+ + ++AK +E + ++M L + EE ++ A E
Sbjct: 409 NQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAE 446
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.140 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,103,376
Number of Sequences: 37866
Number of extensions: 3165843
Number of successful extensions: 18760
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 108
Number of HSP's successfully gapped in prelim test: 65
Number of HSP's that attempted gapping in prelim test: 13809
Number of HSP's gapped (non-prelim): 1370
length of query: 1873
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1756
effective length of database: 13,817,196
effective search space: 24262996176
effective search space used: 24262996176
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.