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Search of human proteins with 15619015
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma
[Homo sapiens]
(351 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 716 0.0
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 612 e-175
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 598 e-171
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 580 e-166
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 570 e-163
gi|46909587 cAMP-dependent protein kinase catalytic subunit beta... 418 e-117
gi|4826948 protein kinase, X-linked [Homo sapiens] 345 5e-95
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens] 270 2e-72
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 269 2e-72
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho... 269 2e-72
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 268 4e-72
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 268 4e-72
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 268 4e-72
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 268 4e-72
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 266 2e-71
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 266 2e-71
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 256 2e-68
gi|62241015 AKT1 kinase [Homo sapiens] 254 6e-68
gi|62241013 AKT1 kinase [Homo sapiens] 254 6e-68
gi|62241011 AKT1 kinase [Homo sapiens] 254 6e-68
gi|4502023 AKT2 kinase [Homo sapiens] 254 1e-67
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 253 2e-67
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 247 1e-65
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 247 1e-65
gi|5453974 protein kinase N2 [Homo sapiens] 243 2e-64
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 236 2e-62
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 234 7e-62
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 234 7e-62
gi|28557781 protein kinase C, eta [Homo sapiens] 233 1e-61
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 233 2e-61
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 716 bits (1848), Expect = 0.0
Identities = 351/351 (100%), Positives = 351/351 (100%)
Query: 1 MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVML 60
MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVML
Sbjct: 1 MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVML 60
Query: 61 VRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLV 120
VRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLV
Sbjct: 61 VRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLV 120
Query: 121 MEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGY 180
MEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGY
Sbjct: 121 MEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGY 180
Query: 181 LQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFY 240
LQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFY
Sbjct: 181 LQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFY 240
Query: 241 ADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFAT 300
ADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFAT
Sbjct: 241 ADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFAT 300
Query: 301 TSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF 351
TSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF
Sbjct: 301 TSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF 351
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 612 bits (1579), Expect = e-175
Identities = 291/351 (82%), Positives = 323/351 (92%)
Query: 1 MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVML 60
MGNA A K ++ESV EFLAKA+ DFL +W +PAQNTA DQFER++TLG GSFGRVML
Sbjct: 1 MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVML 60
Query: 61 VRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLV 120
V+H+ETG HYAMKIL+KQKVVK+KQ+EH LNEKRILQA++FPFLVKL+FSFKDNS LY+V
Sbjct: 61 VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV 120
Query: 121 MEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGY 180
MEYVPGGEMFS L+R+GRFSEPHA FYAAQ+VL +YLHSLDLI+RDLKPENLLIDQQGY
Sbjct: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY 180
Query: 181 LQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFY 240
+QVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMA G+PPF+
Sbjct: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240
Query: 241 ADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFAT 300
ADQPIQIYEKIVSG+VRFPS SSDLK LLR+LLQVDLTKRFGNL+NGV DIKNHKWFAT
Sbjct: 241 ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 300
Query: 301 TSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF 351
T WIAIY++KVEAPFIPK+ GPGD SNFDDYEEEE+R+SINEKC KEFSEF
Sbjct: 301 TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 351
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 598 bits (1541), Expect = e-171
Identities = 283/336 (84%), Positives = 313/336 (93%)
Query: 16 VNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKIL 75
V EFLAKA+ DFL +W +PAQNTA DQFER++TLG GSFGRVMLV+H+ETG HYAMKIL
Sbjct: 8 VKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKIL 67
Query: 76 NKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQR 135
+KQKVVK+KQ+EH LNEKRILQA++FPFLVKL+FSFKDNS LY+VMEYVPGGEMFS L+R
Sbjct: 68 DKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRR 127
Query: 136 VGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGR 195
+GRFSEPHA FYAAQ+VL +YLHSLDLI+RDLKPENLLIDQQGY+QVTDFGFAKRVKGR
Sbjct: 128 IGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR 187
Query: 196 TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGR 255
TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMA G+PPF+ADQPIQIYEKIVSG+
Sbjct: 188 TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 247
Query: 256 VRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPF 315
VRFPS SSDLK LLR+LLQVDLTKRFGNL+NGV DIKNHKWFATT WIAIY++KVEAPF
Sbjct: 248 VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPF 307
Query: 316 IPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF 351
IPK+ GPGD SNFDDYEEEE+R+SINEKC KEFSEF
Sbjct: 308 IPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 343
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 580 bits (1496), Expect = e-166
Identities = 276/351 (78%), Positives = 311/351 (88%)
Query: 1 MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVML 60
MGNA K + ESV EFLAKA+ DFL +W NP QN A + FER +TLG GSFGRVML
Sbjct: 1 MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML 60
Query: 61 VRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLV 120
V+H+ T +YAMKIL+KQKVVK+KQ+EH LNEKRILQA++FPFLV+L+++FKDNS LY+V
Sbjct: 61 VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV 120
Query: 121 MEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGY 180
MEYVPGGEMFS L+R+GRFSEPHA FYAAQ+VL +YLHSLDLI+RDLKPENLLID QGY
Sbjct: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY 180
Query: 181 LQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFY 240
+QVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMA G+PPF+
Sbjct: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240
Query: 241 ADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFAT 300
ADQPIQIYEKIVSG+VRFPS SSDLK LLR+LLQVDLTKRFGNL+NGV DIK HKWFAT
Sbjct: 241 ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT 300
Query: 301 TSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF 351
T WIAIY++KVEAPFIPK+ G GD SNFDDYEEE++R+SI EKCAKEF EF
Sbjct: 301 TDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 351
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 570 bits (1469), Expect = e-163
Identities = 269/339 (79%), Positives = 305/339 (89%)
Query: 13 EESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAM 72
+ S+ EFLAKA+ DFL +W NP QN A + FER +TLG GSFGRVMLV+H+ T +YAM
Sbjct: 60 DRSMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAM 119
Query: 73 KILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSR 132
KIL+KQKVVK+KQ+EH LNEKRILQA++FPFLV+L+++FKDNS LY+VMEYVPGGEMFS
Sbjct: 120 KILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSH 179
Query: 133 LQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRV 192
L+R+GRFSEPHA FYAAQ+VL +YLHSLDLI+RDLKPENLLID QGY+QVTDFGFAKRV
Sbjct: 180 LRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRV 239
Query: 193 KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIV 252
KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMA G+PPF+ADQPIQIYEKIV
Sbjct: 240 KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 299
Query: 253 SGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVE 312
SG+VRFPS SSDLK LLR+LLQVDLTKRFGNL+NGV DIK HKWFATT WIAIY++KVE
Sbjct: 300 SGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVE 359
Query: 313 APFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF 351
APFIPK+ G GD SNFDDYEEE++R+SI EKCAKEF EF
Sbjct: 360 APFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 398
>gi|46909587 cAMP-dependent protein kinase catalytic subunit beta
isoform 3 [Homo sapiens]
Length = 257
Score = 418 bits (1074), Expect = e-117
Identities = 199/255 (78%), Positives = 226/255 (88%)
Query: 1 MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVML 60
MGNA K + ESV EFLAKA+ DFL +W NP QN A + FER +TLG GSFGRVML
Sbjct: 1 MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML 60
Query: 61 VRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLV 120
V+H+ T +YAMKIL+KQKVVK+KQ+EH LNEKRILQA++FPFLV+L+++FKDNS LY+V
Sbjct: 61 VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV 120
Query: 121 MEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGY 180
MEYVPGGEMFS L+R+GRFSEPHA FYAAQ+VL +YLHSLDLI+RDLKPENLLID QGY
Sbjct: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY 180
Query: 181 LQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFY 240
+QVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMA G+PPF+
Sbjct: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240
Query: 241 ADQPIQIYEKIVSGR 255
ADQPIQIYEKIVSG+
Sbjct: 241 ADQPIQIYEKIVSGK 255
>gi|4826948 protein kinase, X-linked [Homo sapiens]
Length = 358
Score = 345 bits (884), Expect = 5e-95
Identities = 147/303 (48%), Positives = 224/303 (73%)
Query: 33 NPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNE 92
+P S F+ L T+G G+FGRV LV+ + +A+K+++ V+++KQ +H+ NE
Sbjct: 38 SPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNE 97
Query: 93 KRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVV 152
K +L+ + PFL++L +++ D +LY++MEYVPGGE+FS L+ GRFS FY+A+++
Sbjct: 98 KSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEII 157
Query: 153 LAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWTLCGTPEYLAPEIIL 212
A++YLHS ++++RDLKPEN+L+D+ G++++TDFGFAK++ RTWTLCGTPEYLAPE+I
Sbjct: 158 CAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQ 217
Query: 213 SKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRS 272
SKG+ +AVDWWALG+LI+EM GFPPF+ D P IY+KI++G++ FP L +K L++
Sbjct: 218 SKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKK 277
Query: 273 LLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYE 332
LL VD T+R GN++NG D+K+H+WF + W A+ ++K++ P +PK G GD SNF+ Y
Sbjct: 278 LLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYP 337
Query: 333 EEE 335
E +
Sbjct: 338 END 340
>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
Length = 762
Score = 270 bits (689), Expect = 2e-72
Identities = 135/304 (44%), Positives = 200/304 (65%), Gaps = 7/304 (2%)
Query: 39 ASSDQFERLR---TLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRI 95
+SS F+ L TLG+G FGRV LV+ + +AMK + K+ +V KQ EH+ +EKRI
Sbjct: 445 SSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRI 504
Query: 96 LQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAV 155
L+ + PF+VKL +FKDN Y+Y+++E GGE++S L+ G F EP + F A V A
Sbjct: 505 LEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAF 564
Query: 156 QYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILS 213
YLH L +I+RDLKPENL++D +GYL++ DFGFAK++ +TWT CGTPEY+APE+IL+
Sbjct: 565 DYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILN 624
Query: 214 KGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSG--RVRFPSKLSSDLKHLLR 271
KG++ +VD+W+LG+L+YE+ G PPF + Y I+ G ++ FP K++ + L+R
Sbjct: 625 KGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIR 684
Query: 272 SLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDY 331
L + + T+R GNL+NG+ DIK H+W +W + + + +P + GP D S FD Y
Sbjct: 685 RLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKY 744
Query: 332 EEEE 335
E+
Sbjct: 745 PPEK 748
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 269 bits (688), Expect = 2e-72
Identities = 133/296 (44%), Positives = 196/296 (66%), Gaps = 5/296 (1%)
Query: 44 FERLRTLGMGSFGRVMLVR-HQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFP 102
F + TLG+G FGRV LV+ E +AMKIL K+ +V +Q EHI +EK+I+Q
Sbjct: 360 FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSD 419
Query: 103 FLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLD 162
F+V+L +FKD+ YLY++ME GGE+++ L+ G F + FY A VV A YLHS
Sbjct: 420 FIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKG 479
Query: 163 LIHRDLKPENLLIDQQGYLQVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSKGYNKAV 220
+I+RDLKPENL++D +GY ++ DFGFAK++ +TWT CGTPEY+APEIIL+KG++ +
Sbjct: 480 IIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISA 539
Query: 221 DWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSG--RVRFPSKLSSDLKHLLRSLLQVDL 278
D+W+LG+L+YE+ G PPF P++ Y I+ G + FP K++ + +L++ L + +
Sbjct: 540 DYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNP 599
Query: 279 TKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEE 334
++R GNL+NGV DI+ HKWF +W + + + P IP P D SNFD + E+
Sbjct: 600 SERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPED 655
>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
sapiens]
Length = 686
Score = 269 bits (688), Expect = 2e-72
Identities = 133/296 (44%), Positives = 196/296 (66%), Gaps = 5/296 (1%)
Query: 44 FERLRTLGMGSFGRVMLVR-HQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFP 102
F + TLG+G FGRV LV+ E +AMKIL K+ +V +Q EHI +EK+I+Q
Sbjct: 375 FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSD 434
Query: 103 FLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLD 162
F+V+L +FKD+ YLY++ME GGE+++ L+ G F + FY A VV A YLHS
Sbjct: 435 FIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKG 494
Query: 163 LIHRDLKPENLLIDQQGYLQVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSKGYNKAV 220
+I+RDLKPENL++D +GY ++ DFGFAK++ +TWT CGTPEY+APEIIL+KG++ +
Sbjct: 495 IIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISA 554
Query: 221 DWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSG--RVRFPSKLSSDLKHLLRSLLQVDL 278
D+W+LG+L+YE+ G PPF P++ Y I+ G + FP K++ + +L++ L + +
Sbjct: 555 DYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNP 614
Query: 279 TKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEE 334
++R GNL+NGV DI+ HKWF +W + + + P IP P D SNFD + E+
Sbjct: 615 SERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPED 670
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 268 bits (686), Expect = 4e-72
Identities = 133/315 (42%), Positives = 203/315 (64%), Gaps = 7/315 (2%)
Query: 34 PAQNT-ASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNE 92
P+ N A F L+ +G GSFG+V+L RH+ YA+K+L K+ ++K K+ +HI++E
Sbjct: 87 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 146
Query: 93 KRIL-QAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQV 151
+ +L + + PFLV L FSF+ LY V++Y+ GGE+F LQR F EP A FYAA++
Sbjct: 147 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 206
Query: 152 VLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAK---RVKGRTWTLCGTPEYLAP 208
A+ YLHSL++++RDLKPEN+L+D QG++ +TDFG K T T CGTPEYLAP
Sbjct: 207 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 266
Query: 209 EIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKH 268
E++ + Y++ VDWW LG ++YEM G PPFY+ ++Y+ I++ ++ +++ +H
Sbjct: 267 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARH 326
Query: 269 LLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNF 328
LL LLQ D TKR G ++ +IK+H +F+ +W + KK+ PF P +GP D +F
Sbjct: 327 LLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 385
Query: 329 D-DYEEEELRISINE 342
D ++ EE + SI +
Sbjct: 386 DPEFTEEPVPNSIGK 400
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 268 bits (686), Expect = 4e-72
Identities = 133/315 (42%), Positives = 203/315 (64%), Gaps = 7/315 (2%)
Query: 34 PAQNT-ASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNE 92
P+ N A F L+ +G GSFG+V+L RH+ YA+K+L K+ ++K K+ +HI++E
Sbjct: 101 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 160
Query: 93 KRIL-QAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQV 151
+ +L + + PFLV L FSF+ LY V++Y+ GGE+F LQR F EP A FYAA++
Sbjct: 161 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 220
Query: 152 VLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAK---RVKGRTWTLCGTPEYLAP 208
A+ YLHSL++++RDLKPEN+L+D QG++ +TDFG K T T CGTPEYLAP
Sbjct: 221 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 280
Query: 209 EIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKH 268
E++ + Y++ VDWW LG ++YEM G PPFY+ ++Y+ I++ ++ +++ +H
Sbjct: 281 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARH 340
Query: 269 LLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNF 328
LL LLQ D TKR G ++ +IK+H +F+ +W + KK+ PF P +GP D +F
Sbjct: 341 LLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 399
Query: 329 D-DYEEEELRISINE 342
D ++ EE + SI +
Sbjct: 400 DPEFTEEPVPNSIGK 414
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 268 bits (686), Expect = 4e-72
Identities = 133/315 (42%), Positives = 203/315 (64%), Gaps = 7/315 (2%)
Query: 34 PAQNT-ASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNE 92
P+ N A F L+ +G GSFG+V+L RH+ YA+K+L K+ ++K K+ +HI++E
Sbjct: 115 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 174
Query: 93 KRIL-QAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQV 151
+ +L + + PFLV L FSF+ LY V++Y+ GGE+F LQR F EP A FYAA++
Sbjct: 175 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 234
Query: 152 VLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAK---RVKGRTWTLCGTPEYLAP 208
A+ YLHSL++++RDLKPEN+L+D QG++ +TDFG K T T CGTPEYLAP
Sbjct: 235 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 294
Query: 209 EIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKH 268
E++ + Y++ VDWW LG ++YEM G PPFY+ ++Y+ I++ ++ +++ +H
Sbjct: 295 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARH 354
Query: 269 LLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNF 328
LL LLQ D TKR G ++ +IK+H +F+ +W + KK+ PF P +GP D +F
Sbjct: 355 LLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 413
Query: 329 D-DYEEEELRISINE 342
D ++ EE + SI +
Sbjct: 414 DPEFTEEPVPNSIGK 428
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 268 bits (686), Expect = 4e-72
Identities = 133/315 (42%), Positives = 203/315 (64%), Gaps = 7/315 (2%)
Query: 34 PAQNT-ASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNE 92
P+ N A F L+ +G GSFG+V+L RH+ YA+K+L K+ ++K K+ +HI++E
Sbjct: 182 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 241
Query: 93 KRIL-QAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQV 151
+ +L + + PFLV L FSF+ LY V++Y+ GGE+F LQR F EP A FYAA++
Sbjct: 242 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 301
Query: 152 VLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAK---RVKGRTWTLCGTPEYLAP 208
A+ YLHSL++++RDLKPEN+L+D QG++ +TDFG K T T CGTPEYLAP
Sbjct: 302 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 361
Query: 209 EIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKH 268
E++ + Y++ VDWW LG ++YEM G PPFY+ ++Y+ I++ ++ +++ +H
Sbjct: 362 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARH 421
Query: 269 LLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNF 328
LL LLQ D TKR G ++ +IK+H +F+ +W + KK+ PF P +GP D +F
Sbjct: 422 LLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHF 480
Query: 329 D-DYEEEELRISINE 342
D ++ EE + SI +
Sbjct: 481 DPEFTEEPVPNSIGK 495
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 266 bits (680), Expect = 2e-71
Identities = 135/314 (42%), Positives = 202/314 (64%), Gaps = 6/314 (1%)
Query: 32 GNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILN 91
G A A F+ L+ +G G++G+V+L + + G YA+K+L K+ ++K K+ HI+
Sbjct: 23 GPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMA 82
Query: 92 EKRIL-QAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQ 150
E+ +L + + PFLV L++SF+ LY V++YV GGE+F LQR RF EP A FYAA+
Sbjct: 83 ERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAE 142
Query: 151 VVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAK---RVKGRTWTLCGTPEYLA 207
V A+ YLHSL++I+RDLKPEN+L+D QG++ +TDFG K + T T CGTPEYLA
Sbjct: 143 VASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLA 202
Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLK 267
PE++ + Y++AVDWW LG ++YEM G PPFY+ Q+YE I+ ++ P +
Sbjct: 203 PEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAAC 262
Query: 268 HLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASN 327
LL+SLL D +R G+ + + +IKNH +F+ +W +Y K++ PF P TGP D +
Sbjct: 263 DLLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKH 321
Query: 328 FD-DYEEEELRISI 340
FD ++ +E + SI
Sbjct: 322 FDPEFTQEAVSKSI 335
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 266 bits (680), Expect = 2e-71
Identities = 135/314 (42%), Positives = 202/314 (64%), Gaps = 6/314 (1%)
Query: 32 GNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILN 91
G A A F+ L+ +G G++G+V+L + + G YA+K+L K+ ++K K+ HI+
Sbjct: 83 GPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMA 142
Query: 92 EKRIL-QAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQ 150
E+ +L + + PFLV L++SF+ LY V++YV GGE+F LQR RF EP A FYAA+
Sbjct: 143 ERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAE 202
Query: 151 VVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAK---RVKGRTWTLCGTPEYLA 207
V A+ YLHSL++I+RDLKPEN+L+D QG++ +TDFG K + T T CGTPEYLA
Sbjct: 203 VASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLA 262
Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLK 267
PE++ + Y++AVDWW LG ++YEM G PPFY+ Q+YE I+ ++ P +
Sbjct: 263 PEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAAC 322
Query: 268 HLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASN 327
LL+SLL D +R G+ + + +IKNH +F+ +W +Y K++ PF P TGP D +
Sbjct: 323 DLLQSLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKH 381
Query: 328 FD-DYEEEELRISI 340
FD ++ +E + SI
Sbjct: 382 FDPEFTQEAVSKSI 395
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 256 bits (655), Expect = 2e-68
Identities = 131/307 (42%), Positives = 188/307 (61%), Gaps = 4/307 (1%)
Query: 42 DQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDF 101
+ F+ L+ LG G+FG+V+LVR + +G +YAMKIL K+ ++ +V H L E R+L+
Sbjct: 146 NDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRH 205
Query: 102 PFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSL 161
PFL L++SF+ L VMEYV GGE+F L R FSE FY A++V A+ YLHS
Sbjct: 206 PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSG 265
Query: 162 DLIHRDLKPENLLIDQQGYLQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYNK 218
+++RDLK ENL++D+ G++++TDFG K T CGTPEYLAPE++ Y +
Sbjct: 266 KIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGR 325
Query: 219 AVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDL 278
AVDWW LGV++YEM G PFY +++E I+ ++FP LSSD K LL LL D
Sbjct: 326 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDP 385
Query: 279 TKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFD-DYEEEELR 337
KR G + +I H +F+ +W +Y+KK+ PF P+ T D FD ++ + +
Sbjct: 386 NKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTIT 445
Query: 338 ISINEKC 344
I+ EKC
Sbjct: 446 ITPPEKC 452
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 254 bits (650), Expect = 6e-68
Identities = 135/321 (42%), Positives = 192/321 (59%), Gaps = 19/321 (5%)
Query: 29 YRWGNPAQNTASSD---------------QFERLRTLGMGSFGRVMLVRHQETGGHYAMK 73
+R G+P+ N+ + + +FE L+ LG G+FG+V+LV+ + TG +YAMK
Sbjct: 120 FRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMK 179
Query: 74 ILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRL 133
IL K+ +V +V H L E R+LQ PFL L++SF+ + L VMEY GGE+F L
Sbjct: 180 ILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL 239
Query: 134 QRVGRFSEPHACFYAAQVVLAVQYLHS-LDLIHRDLKPENLLIDQQGYLQVTDFGFAKR- 191
R FSE A FY A++V A+ YLHS ++++RDLK ENL++D+ G++++TDFG K
Sbjct: 240 SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG 299
Query: 192 -VKGRTW-TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYE 249
G T T CGTPEYLAPE++ Y +AVDWW LGV++YEM G PFY +++E
Sbjct: 300 IKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFE 359
Query: 250 KIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEK 309
I+ +RFP L + K LL LL+ D +R G +I H++FA W +YEK
Sbjct: 360 LILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEK 419
Query: 310 KVEAPFIPKYTGPGDASNFDD 330
K+ PF P+ T D FD+
Sbjct: 420 KLSPPFKPQVTSETDTRYFDE 440
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 254 bits (650), Expect = 6e-68
Identities = 135/321 (42%), Positives = 192/321 (59%), Gaps = 19/321 (5%)
Query: 29 YRWGNPAQNTASSD---------------QFERLRTLGMGSFGRVMLVRHQETGGHYAMK 73
+R G+P+ N+ + + +FE L+ LG G+FG+V+LV+ + TG +YAMK
Sbjct: 120 FRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMK 179
Query: 74 ILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRL 133
IL K+ +V +V H L E R+LQ PFL L++SF+ + L VMEY GGE+F L
Sbjct: 180 ILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL 239
Query: 134 QRVGRFSEPHACFYAAQVVLAVQYLHS-LDLIHRDLKPENLLIDQQGYLQVTDFGFAKR- 191
R FSE A FY A++V A+ YLHS ++++RDLK ENL++D+ G++++TDFG K
Sbjct: 240 SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG 299
Query: 192 -VKGRTW-TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYE 249
G T T CGTPEYLAPE++ Y +AVDWW LGV++YEM G PFY +++E
Sbjct: 300 IKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFE 359
Query: 250 KIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEK 309
I+ +RFP L + K LL LL+ D +R G +I H++FA W +YEK
Sbjct: 360 LILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEK 419
Query: 310 KVEAPFIPKYTGPGDASNFDD 330
K+ PF P+ T D FD+
Sbjct: 420 KLSPPFKPQVTSETDTRYFDE 440
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 254 bits (650), Expect = 6e-68
Identities = 135/321 (42%), Positives = 192/321 (59%), Gaps = 19/321 (5%)
Query: 29 YRWGNPAQNTASSD---------------QFERLRTLGMGSFGRVMLVRHQETGGHYAMK 73
+R G+P+ N+ + + +FE L+ LG G+FG+V+LV+ + TG +YAMK
Sbjct: 120 FRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMK 179
Query: 74 ILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRL 133
IL K+ +V +V H L E R+LQ PFL L++SF+ + L VMEY GGE+F L
Sbjct: 180 ILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHL 239
Query: 134 QRVGRFSEPHACFYAAQVVLAVQYLHS-LDLIHRDLKPENLLIDQQGYLQVTDFGFAKR- 191
R FSE A FY A++V A+ YLHS ++++RDLK ENL++D+ G++++TDFG K
Sbjct: 240 SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG 299
Query: 192 -VKGRTW-TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYE 249
G T T CGTPEYLAPE++ Y +AVDWW LGV++YEM G PFY +++E
Sbjct: 300 IKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFE 359
Query: 250 KIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEK 309
I+ +RFP L + K LL LL+ D +R G +I H++FA W +YEK
Sbjct: 360 LILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEK 419
Query: 310 KVEAPFIPKYTGPGDASNFDD 330
K+ PF P+ T D FD+
Sbjct: 420 KLSPPFKPQVTSETDTRYFDE 440
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 254 bits (648), Expect = 1e-67
Identities = 126/299 (42%), Positives = 188/299 (62%), Gaps = 3/299 (1%)
Query: 35 AQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKR 94
A+ + + F+ L+ LG G+FG+V+LVR + TG +YAMKIL K+ ++ +V H + E R
Sbjct: 143 ARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESR 202
Query: 95 ILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLA 154
+LQ PFL L+++F+ + L VMEY GGE+F L R F+E A FY A++V A
Sbjct: 203 VLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSA 262
Query: 155 VQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEII 211
++YLHS D+++RD+K ENL++D+ G++++TDFG K G T T CGTPEYLAPE++
Sbjct: 263 LEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVL 322
Query: 212 LSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLR 271
Y +AVDWW LGV++YEM G PFY +++E I+ +RFP LS + K LL
Sbjct: 323 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLA 382
Query: 272 SLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDD 330
LL+ D +R G + ++ H++F + +W + +KK+ PF P+ T D FDD
Sbjct: 383 GLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDD 441
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 253 bits (646), Expect = 2e-67
Identities = 130/306 (42%), Positives = 187/306 (61%), Gaps = 4/306 (1%)
Query: 42 DQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDF 101
+ F+ L+ LG G+FG+V+LVR + +G +YAMKIL K+ ++ +V H L E R+L+
Sbjct: 146 NDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRH 205
Query: 102 PFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSL 161
PFL L++SF+ L VMEYV GGE+F L R FSE FY A++V A+ YLHS
Sbjct: 206 PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSG 265
Query: 162 DLIHRDLKPENLLIDQQGYLQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYNK 218
+++RDLK ENL++D+ G++++TDFG K T CGTPEYLAPE++ Y +
Sbjct: 266 KIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGR 325
Query: 219 AVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDL 278
AVDWW LGV++YEM G PFY +++E I+ ++FP LSSD K LL LL D
Sbjct: 326 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDP 385
Query: 279 TKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFD-DYEEEELR 337
KR G + +I H +F+ +W +Y+KK+ PF P+ T D FD ++ + +
Sbjct: 386 NKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTIT 445
Query: 338 ISINEK 343
I+ EK
Sbjct: 446 ITPPEK 451
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 247 bits (630), Expect = 1e-65
Identities = 130/331 (39%), Positives = 193/331 (58%), Gaps = 8/331 (2%)
Query: 9 DTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGG 68
+ E E S + + ++ L GNP A F+ L+ +G GSFG+V+L + + G
Sbjct: 130 EDEDERSSQKLHSTSQNINLGPSGNPH---AKPTDFDFLKVIGKGSFGKVLLAKRKLDGK 186
Query: 69 HYAMKILNKQKVVKMKQVEHILNEKRIL-QAIDFPFLVKLQFSFKDNSYLYLVMEYVPGG 127
YA+K+L K+ V+ K+ +HI+ E+ +L + + PFLV L +SF+ LY V+++V GG
Sbjct: 187 FYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGG 246
Query: 128 EMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFG 187
E+F LQR F E A FYAA++ A+ YLHS+ +++RDLKPEN+L+D G++ +TDFG
Sbjct: 247 ELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFG 306
Query: 188 FAKR---VKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQP 244
K + T T CGTPEYLAPE+I + Y+ VDWW LG ++YEM G PPFY
Sbjct: 307 LCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDV 366
Query: 245 IQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWI 304
++Y+ I+ + +S +L LL+ D R G + +I+NH +F + SW
Sbjct: 367 AEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLG-AKEDFLEIQNHPFFESLSWA 425
Query: 305 AIYEKKVEAPFIPKYTGPGDASNFDDYEEEE 335
+ +KK+ PF P GP D NFD EE
Sbjct: 426 DLVQKKIPPPFNPNVAGPDDIRNFDTAFTEE 456
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 247 bits (630), Expect = 1e-65
Identities = 130/331 (39%), Positives = 193/331 (58%), Gaps = 8/331 (2%)
Query: 9 DTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGG 68
+ E E S + + ++ L GNP A F+ L+ +G GSFG+V+L + + G
Sbjct: 130 EDEDERSSQKLHSTSQNINLGPSGNPH---AKPTDFDFLKVIGKGSFGKVLLAKRKLDGK 186
Query: 69 HYAMKILNKQKVVKMKQVEHILNEKRIL-QAIDFPFLVKLQFSFKDNSYLYLVMEYVPGG 127
YA+K+L K+ V+ K+ +HI+ E+ +L + + PFLV L +SF+ LY V+++V GG
Sbjct: 187 FYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGG 246
Query: 128 EMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFG 187
E+F LQR F E A FYAA++ A+ YLHS+ +++RDLKPEN+L+D G++ +TDFG
Sbjct: 247 ELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFG 306
Query: 188 FAKR---VKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQP 244
K + T T CGTPEYLAPE+I + Y+ VDWW LG ++YEM G PPFY
Sbjct: 307 LCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDV 366
Query: 245 IQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWI 304
++Y+ I+ + +S +L LL+ D R G + +I+NH +F + SW
Sbjct: 367 AEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLG-AKEDFLEIQNHPFFESLSWA 425
Query: 305 AIYEKKVEAPFIPKYTGPGDASNFDDYEEEE 335
+ +KK+ PF P GP D NFD EE
Sbjct: 426 DLVQKKIPPPFNPNVAGPDDIRNFDTAFTEE 456
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 243 bits (619), Expect = 2e-64
Identities = 124/293 (42%), Positives = 177/293 (60%), Gaps = 7/293 (2%)
Query: 44 FERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAID--- 100
F LG G FG+V+L ++ T +A+K L K +V +V+ ++ EKRI + ++
Sbjct: 657 FRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVR 716
Query: 101 FPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHS 160
PFLV L F+ ++ VMEY GG++ + FSEP A FYAA VVL +QYLH
Sbjct: 717 HPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-TDVFSEPRAVFYAACVVLGLQYLHE 775
Query: 161 LDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKGYN 217
+++RDLK +NLL+D +G++++ DFG K G RT T CGTPE+LAPE++ Y
Sbjct: 776 HKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYT 835
Query: 218 KAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVD 277
+AVDWW LGVLIYEM VG PF D ++++ IV+ VR+P LS++ ++R LL+ +
Sbjct: 836 RAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRN 895
Query: 278 LTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDD 330
+R G D+K H +F W A+ +KKV+ PFIP G D SNFDD
Sbjct: 896 PERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDD 948
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 236 bits (603), Expect = 2e-62
Identities = 118/293 (40%), Positives = 181/293 (61%), Gaps = 7/293 (2%)
Query: 44 FERLRTLGMGSFGRVMLVRHQE---TGGHYAMKILNKQKVVK-MKQVEHILNEKRILQAI 99
FE LR LG G +G+V VR + G YAMK+L K K+V+ K H E+ IL+++
Sbjct: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126
Query: 100 DFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLH 159
PF+V+L ++F+ LYL++E + GGE+F+ L+R G F E ACFY A++ LA+ +LH
Sbjct: 127 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH 186
Query: 160 SLDLIHRDLKPENLLIDQQGYLQVTDFGFAK---RVKGRTWTLCGTPEYLAPEIILSKGY 216
S +I+RDLKPEN+++ QG++++TDFG K T T CGT EY+APEI++ G+
Sbjct: 187 SQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGH 246
Query: 217 NKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQV 276
N+AVDWW+LG L+Y+M G PPF A+ + +KI+ G++ P L+ D + L++ L+
Sbjct: 247 NRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKR 306
Query: 277 DLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFD 329
+ ++R G D++ H +F +W + +V+ PF P D S FD
Sbjct: 307 NPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFD 359
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 234 bits (598), Expect = 7e-62
Identities = 121/295 (41%), Positives = 180/295 (61%), Gaps = 7/295 (2%)
Query: 42 DQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAID- 100
+ F+ L LG G FG+V+L + +G +A+K L K +V +VE ++ EKRIL A+
Sbjct: 619 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 678
Query: 101 --FPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYL 158
PFLV L F+ ++ VMEY GG++ + FSEP A FY+A VVL +Q+L
Sbjct: 679 AGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFL 737
Query: 159 HSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKG 215
H +++RDLK +NLL+D +GY+++ DFG K G RT T CGTPE+LAPE++
Sbjct: 738 HEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTS 797
Query: 216 YNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQ 275
Y +AVDWW LGVL+YEM VG PF D ++++ IV+ VR+P LS++ ++R LL+
Sbjct: 798 YTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLR 857
Query: 276 VDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDD 330
+ +R G+ D+K +F T W A+ +++ PF+P +G D SNFD+
Sbjct: 858 RNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDE 912
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 234 bits (598), Expect = 7e-62
Identities = 121/295 (41%), Positives = 180/295 (61%), Gaps = 7/295 (2%)
Query: 42 DQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAID- 100
+ F+ L LG G FG+V+L + +G +A+K L K +V +VE ++ EKRIL A+
Sbjct: 613 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 672
Query: 101 --FPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYL 158
PFLV L F+ ++ VMEY GG++ + FSEP A FY+A VVL +Q+L
Sbjct: 673 AGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFL 731
Query: 159 HSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKG 215
H +++RDLK +NLL+D +GY+++ DFG K G RT T CGTPE+LAPE++
Sbjct: 732 HEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTS 791
Query: 216 YNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQ 275
Y +AVDWW LGVL+YEM VG PF D ++++ IV+ VR+P LS++ ++R LL+
Sbjct: 792 YTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLR 851
Query: 276 VDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDD 330
+ +R G+ D+K +F T W A+ +++ PF+P +G D SNFD+
Sbjct: 852 RNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDE 906
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 233 bits (595), Expect = 1e-61
Identities = 127/310 (40%), Positives = 186/310 (60%), Gaps = 6/310 (1%)
Query: 32 GNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILN 91
G + N D FE +R LG GSFG+VML R +ETG YA+K+L K +++ VE +
Sbjct: 343 GVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMT 402
Query: 92 EKRILQ-AIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQ 150
EKRIL A + PFL +L F+ L+ VME+V GG++ +Q+ RF E A FYAA+
Sbjct: 403 EKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAE 462
Query: 151 VVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKR--VKG-RTWTLCGTPEYLA 207
++ A+ +LH +I+RDLK +N+L+D +G+ ++ DFG K G T T CGTP+Y+A
Sbjct: 463 IISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIA 522
Query: 208 PEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLK 267
PEI+ Y AVDWWA+GVL+YEM G PF A+ ++E I++ V +P+ L D
Sbjct: 523 PEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDAT 582
Query: 268 HLLRSLLQVDLTKRFGNL-RNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDAS 326
+L+S + + T R G+L + G I H +F W + +++E PF P+ D S
Sbjct: 583 GILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVS 642
Query: 327 NFD-DYEEEE 335
NFD D+ +EE
Sbjct: 643 NFDPDFIKEE 652
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 233 bits (594), Expect = 2e-61
Identities = 117/293 (39%), Positives = 178/293 (60%), Gaps = 7/293 (2%)
Query: 44 FERLRTLGMGSFGRVMLVRH---QETGGHYAMKILNKQKVVK-MKQVEHILNEKRILQAI 99
FE LR LG G +G+V VR TG +AMK+L K +V+ K H E+ IL+ +
Sbjct: 91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150
Query: 100 DFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLH 159
PF+V L ++F+ LYL++EY+ GGE+F +L+R G F E ACFY A++ +A+ +LH
Sbjct: 151 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 210
Query: 160 SLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGR---TWTLCGTPEYLAPEIILSKGY 216
+I+RDLKPEN++++ QG++++TDFG K T T CGT EY+APEI++ G+
Sbjct: 211 QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGH 270
Query: 217 NKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQV 276
N+AVDWW+LG L+Y+M G PPF + + +KI+ ++ P L+ + + LL+ LL+
Sbjct: 271 NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKR 330
Query: 277 DLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFD 329
+ R G G+++ H +F +W + +KVE PF P D S FD
Sbjct: 331 NAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFD 383
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,384,391
Number of Sequences: 37866
Number of extensions: 577829
Number of successful extensions: 3397
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 745
Number of HSP's successfully gapped in prelim test: 66
Number of HSP's that attempted gapping in prelim test: 1125
Number of HSP's gapped (non-prelim): 917
length of query: 351
length of database: 18,247,518
effective HSP length: 103
effective length of query: 248
effective length of database: 14,347,320
effective search space: 3558135360
effective search space used: 3558135360
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.