Search of human proteins with 155723000

Search of human proteins with 155723000

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|155723000 mixed lineage kinase 4 [Homo sapiens]
         (1036 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|155723000 mixed lineage kinase 4 [Homo sapiens]                   2076   0.0  
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho...   920   0.0  
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H...   811   0.0  
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho...   714   0.0  
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho...   244   2e-64
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H...   242   1e-63
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]               223   6e-58
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]               223   6e-58
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso...   163   7e-40
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof...   163   7e-40
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso...   162   1e-39
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso...   162   1e-39
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   148   3e-35
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   148   3e-35
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             143   7e-34
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               143   7e-34
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             143   7e-34
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             143   7e-34
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             143   7e-34
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur...   140   6e-33
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur...   140   6e-33
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur...   140   6e-33
gi|4503787 fyn-related kinase [Homo sapiens]                          138   2e-32
gi|18250298 src-related kinase lacking C-terminal regulatory tyr...   137   5e-32
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]   136   1e-31
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]     136   1e-31
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa...   135   2e-31
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa...   135   2e-31
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]         135   3e-31
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]         135   3e-31

>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
          Length = 1036

 Score = 2076 bits (5379), Expect = 0.0
 Identities = 1036/1036 (100%), Positives = 1036/1036 (100%)

Query: 1    MALRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLR 60
            MALRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLR
Sbjct: 1    MALRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLR 60

Query: 61   RGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVA 120
            RGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVA
Sbjct: 61   RGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVA 120

Query: 121  FERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRH 180
            FERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRH
Sbjct: 121  FERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRH 180

Query: 181  PNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNW 240
            PNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNW
Sbjct: 181  PNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNW 240

Query: 241  AVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTT 300
            AVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTT
Sbjct: 241  AVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTT 300

Query: 301  KMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNK 360
            KMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNK
Sbjct: 301  KMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNK 360

Query: 361  LTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDD 420
            LTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDD
Sbjct: 361  LTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDD 420

Query: 421  WKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELN 480
            WKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELN
Sbjct: 421  WKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELN 480

Query: 481  ILIFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSS 540
            ILIFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSS
Sbjct: 481  ILIFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSS 540

Query: 541  SSSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQM 600
            SSSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQM
Sbjct: 541  SSSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQM 600

Query: 601  KDRTDCKERIRPLSDGNSPWSTILIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPK 660
            KDRTDCKERIRPLSDGNSPWSTILIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPK
Sbjct: 601  KDRTDCKERIRPLSDGNSPWSTILIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPK 660

Query: 661  QIKLPSQAYIDLPLGKDAQRENPAEAESWEEAASANAATVSIEMTPTNSLSRSPQRKKTE 720
            QIKLPSQAYIDLPLGKDAQRENPAEAESWEEAASANAATVSIEMTPTNSLSRSPQRKKTE
Sbjct: 661  QIKLPSQAYIDLPLGKDAQRENPAEAESWEEAASANAATVSIEMTPTNSLSRSPQRKKTE 720

Query: 721  SALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGIFQRASKSRRSASPPTSL 780
            SALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGIFQRASKSRRSASPPTSL
Sbjct: 721  SALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGIFQRASKSRRSASPPTSL 780

Query: 781  PSTCGEASSPPSLPLSSALGILSTPSFSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCP 840
            PSTCGEASSPPSLPLSSALGILSTPSFSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCP
Sbjct: 781  PSTCGEASSPPSLPLSSALGILSTPSFSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCP 840

Query: 841  TAPGSGREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPT 900
            TAPGSGREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPT
Sbjct: 841  TAPGSGREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPT 900

Query: 901  PTGATIISATGASALPLCPSPAPHSHLPREVSPKKHSTVHIVPQRRPASLRSRSDLPQAY 960
            PTGATIISATGASALPLCPSPAPHSHLPREVSPKKHSTVHIVPQRRPASLRSRSDLPQAY
Sbjct: 901  PTGATIISATGASALPLCPSPAPHSHLPREVSPKKHSTVHIVPQRRPASLRSRSDLPQAY 960

Query: 961  PQTAVSQLAQTACVVGRPGPHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRS 1020
            PQTAVSQLAQTACVVGRPGPHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRS
Sbjct: 961  PQTAVSQLAQTACVVGRPGPHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRS 1020

Query: 1021 KTSRPSIYELEKEFLS 1036
            KTSRPSIYELEKEFLS
Sbjct: 1021 KTSRPSIYELEKEFLS 1036


>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
            sapiens]
          Length = 1118

 Score =  920 bits (2379), Expect = 0.0
 Identities = 548/1145 (47%), Positives = 698/1145 (60%), Gaps = 177/1145 (15%)

Query: 19   GAPGGSASSSSTSSGGSASAGAG---------LWAALYDYEARGEDELSLRRGQLVEVLS 69
            GA  G+          +A+ G G          W A+++YEA GEDEL+LR G +VEVLS
Sbjct: 24   GAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLS 83

Query: 70   QDAAVSGDEGWWAGQVQRRLGIFPANYVAP-------CRPAASPAPPPSRPSSPVHVAFE 122
            +D+ VSGDEGWW GQ+ +R+GIFP+NYV P       C+P     P    P   + + F 
Sbjct: 84   KDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGED-PSCYPPIQLLEIDFA 142

Query: 123  RLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPN 182
             L L+E+IG GGFG+VYRA W G EVAVKAAR DP++D +   E+VR+EA+LFAML+HPN
Sbjct: 143  ELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPN 202

Query: 183  IIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAV 242
            II LRGVCL++P+LCLV+EFARGG LNR L+                +RIPP +LVNWAV
Sbjct: 203  IIALRGVCLKEPNLCLVMEFARGGPLNRVLSG---------------KRIPPDILVNWAV 247

Query: 243  QIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKM 302
            QIARGM YLH+EA VPI+HRDLKSSNIL+L+K+E+ D+ NK LKITDFGLAREWHRTTKM
Sbjct: 248  QIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM 307

Query: 303  STAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLT 362
            S AGTYAWMAPEVI++S+FSKGSD+WSYGVLLWELLTGEVP+RGIDGLAVAYGVA+NKL 
Sbjct: 308  SAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLA 367

Query: 363  LPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDDWK 422
            LPIPSTCPEPFAKLM++CW  DPH RPSF  IL+QLT IE +   EMP++SFH +QD+WK
Sbjct: 368  LPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWK 427

Query: 423  LEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELNIL 482
             EIQ+MFD+LR KEKELR+ EEELTRAALQQK+QEELL+RREQ+LAEREID+LERELNI+
Sbjct: 428  HEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNII 487

Query: 483  IFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSSSS 542
            I QL QEKP+VKKRKGKF++SRLKLKDG+RISLPSDFQHK TVQASP +DKR+SL +S S
Sbjct: 488  IHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRS 547

Query: 543  SPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEE-FEDVKRNFKKKGCTWGPNSIQMK 601
            SPP+SPT++PRLRAIQLT  ES+KTWGR++V  +EE  E+ KR  KKKG TWGP ++  K
Sbjct: 548  SPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQK 607

Query: 602  DRTDCKE-----------------------RIRPLSDGNSPWSTI---LIKNQKTMP--- 632
            +     E                        ++ L DG   WS+    L+K  ++ P   
Sbjct: 608  ELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALP 667

Query: 633  ---------------LASLFVDQPGSCEEPKLSPDGLEHRKPKQIKLPSQAYIDLPLGKD 677
                           +  + +++    E P      L+H        PSQ+Y+ +P  + 
Sbjct: 668  GFTSLMEMALLAASWVVPIDIEEDEDSEGPGSGESRLQHS-------PSQSYLCIPFPRG 720

Query: 678  AQRENPAEAESWEEAASANAATVSIEMTPTNSLSR-SPQRKKTESALYGCTVLLASVALG 736
               + P+     EE    N+AT + ++TPTNSL R     ++ E AL GC  +LA+  LG
Sbjct: 721  EDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLG 780

Query: 737  LDLRELHKAQ--AAEEPLP--KEEKKKREGIFQRASKSRRSASPPTSLPSTCGEASSPPS 792
             DL E  K Q    EEP P  +EEKK+REG+FQR+S+ RRS SPP+       E    P 
Sbjct: 781  FDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEE----PM 836

Query: 793  LPL---SSALGILSTPSF----STKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCPTAPGS 845
            L L   S++L +LS  S     ST+ LL+ DS++ +V   PV   S +  P   P     
Sbjct: 837  LLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPV---SPVEAPPLSPCTHN- 892

Query: 846  GREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPTPTGAT 905
                   P ++      +  P+  L  T        ++  +PS HRRT SDG   P   T
Sbjct: 893  -------PLVNVRVERFKRDPNQSLTPT----HVTLTTPSQPSSHRRTPSDGALKP--ET 939

Query: 906  IISATGASALPLCPSPA----------------PHSHLPREVSP--------------KK 935
            ++++   S+  L PSP                 P    P  V P              ++
Sbjct: 940  LLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLER 999

Query: 936  HSTVHIVPQRRPASLRSRSD-----LPQAYPQTAVSQLAQT--------------ACVVG 976
              T+  +P+ RP++ R R D      P     T+ +  + T              + V  
Sbjct: 1000 PKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEE 1059

Query: 977  RPG-----PHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRSKTSRPSIYELE 1031
            RPG     P     L   ERT      LLD D EGQS+D TVPLCR    T RP+ YE++
Sbjct: 1060 RPGLPALLPFQAGPLPPTERT------LLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQ 1113

Query: 1032 KEFLS 1036
            +EF S
Sbjct: 1114 QEFWS 1118


>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
            sapiens]
          Length = 954

 Score =  811 bits (2094), Expect = 0.0
 Identities = 492/1013 (48%), Positives = 624/1013 (61%), Gaps = 107/1013 (10%)

Query: 34   GSASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQR-RLGIF 92
            G+  AG  +W A++DYEA G++EL+LRRG  V+VLSQD AVSGDEGWW GQ+   R+G+F
Sbjct: 13   GTTPAGP-VWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVF 71

Query: 93   PANYVAPCRPAASPAPPPSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKA 152
            P+NYVAP  PAA     P+    P  + F  L+L+E+IG GGFG+VYRA W+G+EVAVKA
Sbjct: 72   PSNYVAPGAPAA-----PAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKA 126

Query: 153  ARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRAL 212
            AR DPE+D A  AE V +EARLF  L+HPNII LRG CL  PHLCLV+E+ARGGAL+R L
Sbjct: 127  ARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL 186

Query: 213  AAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLL 272
            A                RR+PPHVLVNWAVQ+ARGM YLH +A VPI+HRDLKS NIL+L
Sbjct: 187  AG---------------RRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILIL 231

Query: 273  EKIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGV 332
            E IE+ ++ +  LKITDFGLAREWH+TTKMS AGTYAWMAPEVI+ SLFSK SD+WS+GV
Sbjct: 232  EAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGV 291

Query: 333  LLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFA 392
            LLWELLTGEVPYR ID LAVAYGVA+NKLTLPIPSTCPEPFA+L++ECW  DPH RP F 
Sbjct: 292  LLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFG 351

Query: 393  LILEQLTAIEGAVMTEMPQESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAALQ 452
             IL++L  IE + + +MP ESFHS+Q+DWKLEIQ MFD+LRTKEKELRSREEEL RAA +
Sbjct: 352  SILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQE 411

Query: 453  QKSQEELLKRREQQLAEREIDVLERELNILIFQLNQEKPKVKKRKGKFKRSR-LKLKD-G 510
            Q+ QEE L+RREQ+LAERE+D++EREL++L+ QL+QEKP+V+KRKG FKRSR LKL++ G
Sbjct: 412  QRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGG 471

Query: 511  HRISLPSDFQHKITVQASPNLDKRRSLNSSSSSPPSSPTMMPRLRAIQLT---------- 560
              ISLPS F+HKITVQASP LDKR+   S  +SPP+SP+++PRLRAI+LT          
Sbjct: 472  SHISLPSGFEHKITVQASPTLDKRK--GSDGASPPASPSIIPRLRAIRLTPVDCGGSSSG 529

Query: 561  -SDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQMKDRTDCKERIRPLSDGNSP 619
             S   + TW R    ++EE        KKKG TWGP+S   K+R   +ER++ L +G+  
Sbjct: 530  SSSGGSGTWSRGGPPKKEELV----GGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQ 585

Query: 620  WSTI---LIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPKQIKLPSQAYIDLPLGK 676
            WS+    L K+ K  P+A  F       EE   + DG     P     PS  Y+ +PL  
Sbjct: 586  WSSSAPNLGKSPKHTPIAPGFASL-NEMEEFAEAEDGGSSVPPSPYSTPS--YLSVPLPA 642

Query: 677  DAQRENPAEAESWEEAASANAATVSIEMTPTNSLSRSPQRKKTESALYGCTVLLASVALG 736
            +    +P     WE   SA  A                 R++ + AL GC  LL +V LG
Sbjct: 643  E---PSPGARAPWEPTPSAPPARWG-----------HGARRRCDLALLGCATLLGAVGLG 688

Query: 737  LDLRELHKAQAAEEPLPKEEKKKREGI-FQRASKSRRSASPPTSLPSTCGEASSPPSLPL 795
             D+ E   A+AA+    +E+++  +G+ F RA +  R  SPP        +      L  
Sbjct: 689  ADVAE---ARAAD---GEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAP 742

Query: 796  SSALGILSTPS--FSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCPTAPGSGREPALMP 853
            S+ L  LS+ S   ST+ LL+ DS D    +AP        +P   P AP     P+  P
Sbjct: 743  SATLVSLSSVSDCNSTRSLLRSDS-DEAAPAAP--------SPPPSPPAPTPTPSPSTNP 793

Query: 854  RLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPTPTGATIISATGAS 913
             +D +    +  P   L  T      CA S+     HRRT SDG     G    +  G  
Sbjct: 794  LVDLELESFKKDPRQSLTPTHVTAA-CAVSR----GHRRTPSDGALGQRGPPEPAGHGPG 848

Query: 914  A-----LPLCPSPA---PHSHLPREVSPKKHSTVHIVPQRRPASLRSRSDLPQ--AYPQT 963
                   P  P P    P    P E  P + +T+   P+ RPA+ R R D  +  ++ +T
Sbjct: 849  PRDLLDFPRLPDPQALFPARRRPPEF-PGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRT 907

Query: 964  AVSQLAQTACVVGRPGPHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLC 1016
                          PGP   Q            P+LLD D+EGQ++D TVPLC
Sbjct: 908  LTISPPSRPDTPESPGPPSVQ------------PTLLDMDMEGQNQDSTVPLC 948


>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
           sapiens]
          Length = 847

 Score =  714 bits (1842), Expect = 0.0
 Identities = 417/822 (50%), Positives = 528/822 (64%), Gaps = 82/822 (9%)

Query: 3   LRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRG 62
           L+   G+ +   S  GG  GG     S  + G A+    +W AL+DYE  G+DEL+LR+G
Sbjct: 9   LKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANP---VWTALFDYEPSGQDELALRKG 65

Query: 63  QLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVAFE 122
             VEVLS+DAA+SGDEGWWAGQV  ++GIFP+NYV+         PPP   +S     F+
Sbjct: 66  DRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVS-----RGGGPPPCEVAS-----FQ 115

Query: 123 RLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPN 182
            L L+E+IG GGFG+VYR +W+G+ VAVKAARQDP++D +  AESVR+EARLFAML HPN
Sbjct: 116 ELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPN 175

Query: 183 IIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAV 242
           II L+ VCL++P+LCLV+E+A GG L+RALA                RR+PPHVLVNWAV
Sbjct: 176 IIALKAVCLEEPNLCLVMEYAAGGPLSRALAG---------------RRVPPHVLVNWAV 220

Query: 243 QIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKM 302
           QIARGM YLH EA VP++HRDLKS+NILLL+ IE DD+ +KTLKITDFGLAREWH+TT+M
Sbjct: 221 QIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQM 280

Query: 303 STAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLT 362
           S AGTYAWMAPEVIK+S FSKGSD+WS+GVLLWELLTGEVPYRGID LAVAYGVAVNKLT
Sbjct: 281 SAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLT 340

Query: 363 LPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDDWK 422
           LPIPSTCPEPFA+LM +CW QDPH RP FA IL+QL A+E  V+ EMP++SFHSMQ+ WK
Sbjct: 341 LPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWK 400

Query: 423 LEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELNIL 482
            EIQ +FDELR KEKEL SREEELTRAA +Q+SQ E L+RRE  LA+ E++V EREL +L
Sbjct: 401 REIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLL 460

Query: 483 IFQLNQEKPKVKKRKGKFKRSRLKLKD-GHRISLPSDFQHKITVQASPNLDKRRSLNSSS 541
           + Q+++E+P V++R+G FKRS+L+ +D G RIS+P DF+H+ITVQASP LD+RR  N   
Sbjct: 461 LQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRR--NVFE 518

Query: 542 SSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGC-TWGPNSIQM 600
             P  SPT  PR RAIQL   E  + WGR +  R E+      N +++ C  WGP+S + 
Sbjct: 519 VGPGDSPT-FPRFRAIQLEPAEPGQAWGRQSPRRLED----SSNGERRACWAWGPSSPKP 573

Query: 601 KDRTDCKERIRP-------LSDGNSPW---STILIKNQKTMPLASLFVDQPGSCEEPKLS 650
            +  + + R R         SD +SP    ST    N    P  SL  ++P   + P  +
Sbjct: 574 GEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNP-PRPSLEPEEP---KRPVPA 629

Query: 651 PDGLEHRKPKQIK---LPSQAYI-DLPLGKDAQRENPAEAESWEEAASANAATVS---IE 703
             G     PK I+   L   A +  L LG+D Q       E  E   +    T +    E
Sbjct: 630 ERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTE 689

Query: 704 MTPTNSLSRSPQRKKTESALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGI 763
             P+  +  S    KT  +      LL  + + +  R            P+ E++ R G 
Sbjct: 690 PPPSPLICFS---LKTPDSPPTPAPLLLDLGIPVGQRSAKS--------PRREEEPRGG- 737

Query: 764 FQRASKSRRSASPPTSLPSTCGEASSPPSLPLSSALGILSTP 805
                    + SPP   P T   A   P  P S  LG++S P
Sbjct: 738 ---------TVSPP---PGTSRSAPGTPGTPRSPPLGLISRP 767


>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
           sapiens]
          Length = 966

 Score =  244 bits (624), Expect = 2e-64
 Identities = 156/449 (34%), Positives = 239/449 (53%), Gaps = 62/449 (13%)

Query: 119 VAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAML 178
           V FE +   + +G+G  G V+   ++ +EVA+K  R+  E D            +    L
Sbjct: 163 VPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDI-----------KHLRKL 211

Query: 179 RHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLV 238
           +HPNII  +GVC Q P  C+++E+   G L   L              R  R+I P +LV
Sbjct: 212 KHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL--------------RAGRKITPRLLV 257

Query: 239 NWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWH- 297
           +W+  IA GM YLH      I+HRDLKS N+L    + H D     +KI+DFG ++E   
Sbjct: 258 DWSTGIASGMNYLHLHK---IIHRDLKSPNVL----VTHTD----AVKISDFGTSKELSD 306

Query: 298 RTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVA 357
           ++TKMS AGT AWMAPEVI++   S+  DIWS+GV+LWELLTGE+PY+ +D  A+ +GV 
Sbjct: 307 KSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVG 366

Query: 358 VNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSM 417
            N L LP+PSTCP+ F  LMK+ WQ  P  RPSF   L  L  I  A +   PQE++   
Sbjct: 367 SNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLD-IASADVLATPQETYFKS 425

Query: 418 QDDWKLEIQQMFDELRTK--------EKELRSREEELTRAALQQKSQEELLKRREQQLAE 469
           Q +W+ E+++ F++++++        E+ +R R EEL  A   ++  E  L+R      E
Sbjct: 426 QAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYME 485

Query: 470 -----REIDVLERELNILIFQLNQEKPKVKKRKGKFKRSRLK----LKDGHRISLPSDFQ 520
                 ++++ E+EL      + +E+   KK  G +KR  ++         ++       
Sbjct: 486 LSAIMLQLEMREKEL------IKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVP 539

Query: 521 HKITVQAS-PNLDKRRSLNSSSSSPPSSP 548
           HK  +Q   P+L +   + ++  +P +SP
Sbjct: 540 HKSGMQTKRPDLLRSEGIPTTEVAPTASP 568


>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
           sapiens]
          Length = 859

 Score =  242 bits (618), Expect = 1e-63
 Identities = 156/441 (35%), Positives = 240/441 (54%), Gaps = 43/441 (9%)

Query: 119 VAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAML 178
           V FE +   + +G+G  G V+   + G+EVAVK  R   E D            +    L
Sbjct: 120 VPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDI-----------KHLRKL 168

Query: 179 RHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLV 238
           +HPNII  +GVC Q P  C+++EF   G L   L              R  R + P +LV
Sbjct: 169 KHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL--------------RAGRPVTPSLLV 214

Query: 239 NWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWH- 297
           +W++ IA GM YLH      I+HRDLKS N+L    I +DD+    +KI+DFG ++E   
Sbjct: 215 DWSMGIAGGMNYLHLHK---IIHRDLKSPNML----ITYDDV----VKISDFGTSKELSD 263

Query: 298 RTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVA 357
           ++TKMS AGT AWMAPEVI++   S+  DIWS+GV+LWELLTGE+PY+ +D  A+ +GV 
Sbjct: 264 KSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVG 323

Query: 358 VNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSM 417
            N L LP+PS+CP+ F  L+++CW   P  RPSF  IL  L  I  A +   PQE++   
Sbjct: 324 SNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLD-IASADVLSTPQETYFKS 382

Query: 418 QDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLER 477
           Q +W+ E++  F++++++   L   EEEL     ++      ++   ++  ER  + L  
Sbjct: 383 QAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLER-ANNLYM 441

Query: 478 ELNILIFQLNQEKPKVKKRKGKFKRSRLKLKDGH--RISLPSDFQHKITVQASPNLDKRR 535
           ELN L+ QL  ++ ++ +R+   +R    L   H  R  L  +   K+  +   N+ ++ 
Sbjct: 442 ELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKR--NVPQKL 499

Query: 536 SLNSSSSSPPSSPTMMPRLRA 556
           S +S       + +++P+L A
Sbjct: 500 SPHSKRPDILKTESLLPKLDA 520


>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
          Length = 455

 Score =  223 bits (569), Expect = 6e-58
 Identities = 133/359 (37%), Positives = 198/359 (55%), Gaps = 41/359 (11%)

Query: 114 SSPVHVAFERLELKELIGAGGFGQVYRATW--QGQEVAVKAARQDPEQDAAAAAESVRRE 171
           +S V + F+ L+  E  G G FG VYRA W  Q +EVAVK   +            + +E
Sbjct: 6   ASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK------------IEKE 53

Query: 172 ARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARR 231
           A + ++L H NII+  GV L+ P+  +V E+A  G+L   + +             R+  
Sbjct: 54  AEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINS------------NRSEE 101

Query: 232 IPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFG 291
           +    ++ WA  +A+GM YLH EA V ++HRDLKS N+++          +  LKI DFG
Sbjct: 102 MDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIA--------ADGVLKICDFG 153

Query: 292 LAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLA 351
            +R  + TT MS  GT+ WMAPEVI+S   S+  D +SYGV+LWE+LT EVP++G++GL 
Sbjct: 154 ASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQ 213

Query: 352 VAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQ 411
           VA+ V      L IPS+CP  FA+L+ +CW+ D   RPSF  I+  L ++          
Sbjct: 214 VAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKC 273

Query: 412 ESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAER 470
            SF   + +W+ EI+   + L+  E++L  +E+EL       K +E  LK  EQ+L E+
Sbjct: 274 NSFLHNKAEWRCEIEATLERLKKLERDLSFKEQEL-------KERERRLKMWEQKLTEQ 325


>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
          Length = 800

 Score =  223 bits (569), Expect = 6e-58
 Identities = 133/359 (37%), Positives = 198/359 (55%), Gaps = 41/359 (11%)

Query: 114 SSPVHVAFERLELKELIGAGGFGQVYRATW--QGQEVAVKAARQDPEQDAAAAAESVRRE 171
           +S V + F+ L+  E  G G FG VYRA W  Q +EVAVK   +            + +E
Sbjct: 6   ASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK------------IEKE 53

Query: 172 ARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARR 231
           A + ++L H NII+  GV L+ P+  +V E+A  G+L   + +             R+  
Sbjct: 54  AEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINS------------NRSEE 101

Query: 232 IPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFG 291
           +    ++ WA  +A+GM YLH EA V ++HRDLKS N+++          +  LKI DFG
Sbjct: 102 MDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIA--------ADGVLKICDFG 153

Query: 292 LAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLA 351
            +R  + TT MS  GT+ WMAPEVI+S   S+  D +SYGV+LWE+LT EVP++G++GL 
Sbjct: 154 ASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQ 213

Query: 352 VAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQ 411
           VA+ V      L IPS+CP  FA+L+ +CW+ D   RPSF  I+  L ++          
Sbjct: 214 VAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKC 273

Query: 412 ESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAER 470
            SF   + +W+ EI+   + L+  E++L  +E+EL       K +E  LK  EQ+L E+
Sbjct: 274 NSFLHNKAEWRCEIEATLERLKKLERDLSFKEQEL-------KERERRLKMWEQKLTEQ 325


>gi|21735566 mitogen-activated protein kinase kinase kinase 7
           isoform D [Homo sapiens]
          Length = 491

 Score =  163 bits (413), Expect = 7e-40
 Identities = 137/486 (28%), Positives = 220/486 (45%), Gaps = 69/486 (14%)

Query: 110 PSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVR 169
           PS+  +   + ++ +E++E++G G FG V +A W+ ++VA+K    + E+ A        
Sbjct: 22  PSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV----- 76

Query: 170 REARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRA 229
            E R  + + HPNI++L G CL    +CLV+E+A GG+L   L  A   P   A      
Sbjct: 77  -ELRQLSRVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAA----- 128

Query: 230 RRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITD 289
                H + +W +Q ++G+ YLH      ++HRDLK  N+LL+            LKI D
Sbjct: 129 -----HAM-SWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICD 175

Query: 290 FGLAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDG 349
           FG A +  +T   +  G+ AWMAPEV + S +S+  D++S+G++LWE++T   P+  I G
Sbjct: 176 FGTACDI-QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGG 234

Query: 350 LAVAYGVAVNKLTL-PIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTE 408
            A     AV+  T  P+    P+P   LM  CW +DP  RPS    +E++  I   +M  
Sbjct: 235 PAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPS----MEEIVKIMTHLMRY 290

Query: 409 MPQESFHSMQDDWKLEIQ-QMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQL 467
            P         D  L+   Q  DE ++          ++       KS   +     +Q+
Sbjct: 291 FPGA-------DEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNM-----EQV 338

Query: 468 AEREIDVLERELNILIFQLNQEKPKVKKRKGKFKRSRLK----LKDGHRISLP-SDFQHK 522
                 +   E  +L  Q  Q+    +   G  + S ++      +G R+S   S+ + +
Sbjct: 339 PATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEAR 398

Query: 523 ITVQASPNLDKRRSL-------------NSSSSSP------PSSPTMMPRLRAIQLTSDE 563
           I         +RRS+             +S SSSP       S PT     R+   T D+
Sbjct: 399 IAATTGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDD 458

Query: 564 SNKTWG 569
           S  T G
Sbjct: 459 STDTNG 464


>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
           A [Homo sapiens]
          Length = 579

 Score =  163 bits (413), Expect = 7e-40
 Identities = 137/486 (28%), Positives = 220/486 (45%), Gaps = 69/486 (14%)

Query: 110 PSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVR 169
           PS+  +   + ++ +E++E++G G FG V +A W+ ++VA+K    + E+ A        
Sbjct: 22  PSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV----- 76

Query: 170 REARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRA 229
            E R  + + HPNI++L G CL    +CLV+E+A GG+L   L  A   P   A      
Sbjct: 77  -ELRQLSRVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAA----- 128

Query: 230 RRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITD 289
                H + +W +Q ++G+ YLH      ++HRDLK  N+LL+            LKI D
Sbjct: 129 -----HAM-SWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICD 175

Query: 290 FGLAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDG 349
           FG A +  +T   +  G+ AWMAPEV + S +S+  D++S+G++LWE++T   P+  I G
Sbjct: 176 FGTACDI-QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGG 234

Query: 350 LAVAYGVAVNKLTL-PIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTE 408
            A     AV+  T  P+    P+P   LM  CW +DP  RPS    +E++  I   +M  
Sbjct: 235 PAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPS----MEEIVKIMTHLMRY 290

Query: 409 MPQESFHSMQDDWKLEIQ-QMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQL 467
            P         D  L+   Q  DE ++          ++       KS   +     +Q+
Sbjct: 291 FPGA-------DEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNM-----EQV 338

Query: 468 AEREIDVLERELNILIFQLNQEKPKVKKRKGKFKRSRLK----LKDGHRISLP-SDFQHK 522
                 +   E  +L  Q  Q+    +   G  + S ++      +G R+S   S+ + +
Sbjct: 339 PATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEAR 398

Query: 523 ITVQASPNLDKRRSL-------------NSSSSSP------PSSPTMMPRLRAIQLTSDE 563
           I         +RRS+             +S SSSP       S PT     R+   T D+
Sbjct: 399 IAATTGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDD 458

Query: 564 SNKTWG 569
           S  T G
Sbjct: 459 STDTNG 464


>gi|21735564 mitogen-activated protein kinase kinase kinase 7
           isoform C [Homo sapiens]
          Length = 518

 Score =  162 bits (411), Expect = 1e-39
 Identities = 99/291 (34%), Positives = 156/291 (53%), Gaps = 28/291 (9%)

Query: 110 PSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVR 169
           PS+  +   + ++ +E++E++G G FG V +A W+ ++VA+K    + E+ A        
Sbjct: 22  PSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV----- 76

Query: 170 REARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRA 229
            E R  + + HPNI++L G CL    +CLV+E+A GG+L   L  A   P   A      
Sbjct: 77  -ELRQLSRVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAA----- 128

Query: 230 RRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITD 289
                H + +W +Q ++G+ YLH      ++HRDLK  N+LL+            LKI D
Sbjct: 129 -----HAM-SWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICD 175

Query: 290 FGLAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDG 349
           FG A +  +T   +  G+ AWMAPEV + S +S+  D++S+G++LWE++T   P+  I G
Sbjct: 176 FGTACDI-QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGG 234

Query: 350 LAVAYGVAVNKLTL-PIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLT 399
            A     AV+  T  P+    P+P   LM  CW +DP  RPS   I++ +T
Sbjct: 235 PAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMT 285


>gi|21735562 mitogen-activated protein kinase kinase kinase 7
           isoform B [Homo sapiens]
          Length = 606

 Score =  162 bits (411), Expect = 1e-39
 Identities = 99/291 (34%), Positives = 156/291 (53%), Gaps = 28/291 (9%)

Query: 110 PSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVR 169
           PS+  +   + ++ +E++E++G G FG V +A W+ ++VA+K    + E+ A        
Sbjct: 22  PSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV----- 76

Query: 170 REARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRA 229
            E R  + + HPNI++L G CL    +CLV+E+A GG+L   L  A   P   A      
Sbjct: 77  -ELRQLSRVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAA----- 128

Query: 230 RRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITD 289
                H + +W +Q ++G+ YLH      ++HRDLK  N+LL+            LKI D
Sbjct: 129 -----HAM-SWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICD 175

Query: 290 FGLAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDG 349
           FG A +  +T   +  G+ AWMAPEV + S +S+  D++S+G++LWE++T   P+  I G
Sbjct: 176 FGTACDI-QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGG 234

Query: 350 LAVAYGVAVNKLTL-PIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLT 399
            A     AV+  T  P+    P+P   LM  CW +DP  RPS   I++ +T
Sbjct: 235 PAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMT 285


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  148 bits (373), Expect = 3e-35
 Identities = 105/323 (32%), Positives = 161/323 (49%), Gaps = 45/323 (13%)

Query: 106 PAPPPSRPS----SPVHVAFER----LELKELIGAGGFGQVYRATWQGQE--VAVKAARQ 155
           PAP  ++P+    SP +  +E     + +K  +G G +G+VY   W+     VAVK  ++
Sbjct: 216 PAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKE 275

Query: 156 DPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAA 215
           D  +      E   +EA +   ++HPN+++L GVC ++P   ++ EF   G L   L   
Sbjct: 276 DTME-----VEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLREC 330

Query: 216 NAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKI 275
           N             + +   VL+  A QI+  M YL ++ F+   HRDL + N L+ E  
Sbjct: 331 NR------------QEVNAVVLLYMATQISSAMEYLEKKNFI---HRDLAARNCLVGE-- 373

Query: 276 EHDDICNKTLKITDFGLAREWHRTTKMSTAGT---YAWMAPEVIKSSLFSKGSDIWSYGV 332
                 N  +K+ DFGL+R     T  + AG      W APE +  + FS  SD+W++GV
Sbjct: 374 ------NHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGV 427

Query: 333 LLWELLT-GEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSF 391
           LLWE+ T G  PY GID L+  Y +      +  P  CPE   +LM+ CWQ +P  RPSF
Sbjct: 428 LLWEIATYGMSPYPGID-LSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSF 486

Query: 392 ALILEQLTAI--EGAVMTEMPQE 412
           A I +    +  E ++  E+ +E
Sbjct: 487 AEIHQAFETMFQESSISDEVEKE 509


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  148 bits (373), Expect = 3e-35
 Identities = 105/323 (32%), Positives = 161/323 (49%), Gaps = 45/323 (13%)

Query: 106 PAPPPSRPS----SPVHVAFER----LELKELIGAGGFGQVYRATWQGQE--VAVKAARQ 155
           PAP  ++P+    SP +  +E     + +K  +G G +G+VY   W+     VAVK  ++
Sbjct: 235 PAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKE 294

Query: 156 DPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAA 215
           D  +      E   +EA +   ++HPN+++L GVC ++P   ++ EF   G L   L   
Sbjct: 295 DTME-----VEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLREC 349

Query: 216 NAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKI 275
           N             + +   VL+  A QI+  M YL ++ F+   HRDL + N L+ E  
Sbjct: 350 NR------------QEVNAVVLLYMATQISSAMEYLEKKNFI---HRDLAARNCLVGE-- 392

Query: 276 EHDDICNKTLKITDFGLAREWHRTTKMSTAGT---YAWMAPEVIKSSLFSKGSDIWSYGV 332
                 N  +K+ DFGL+R     T  + AG      W APE +  + FS  SD+W++GV
Sbjct: 393 ------NHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGV 446

Query: 333 LLWELLT-GEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSF 391
           LLWE+ T G  PY GID L+  Y +      +  P  CPE   +LM+ CWQ +P  RPSF
Sbjct: 447 LLWEIATYGMSPYPGID-LSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSF 505

Query: 392 ALILEQLTAI--EGAVMTEMPQE 412
           A I +    +  E ++  E+ +E
Sbjct: 506 AEIHQAFETMFQESSISDEVEKE 528


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  143 bits (361), Expect = 7e-34
 Identities = 100/301 (33%), Positives = 148/301 (49%), Gaps = 43/301 (14%)

Query: 106 PAPPPSRPS----SPVHVAFER----LELKELIGAGGFGQVYRATWQGQE--VAVKAARQ 155
           PAP  ++P+    SP+H  +E     + +K  +G G +G+VY   W+     VAVK  ++
Sbjct: 247 PAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKE 306

Query: 156 DPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAA 215
           D  +      E   +EA +   ++HPN+++L GVC  +P   +V E+   G L   L   
Sbjct: 307 DTME-----VEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLREC 361

Query: 216 NAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKI 275
           N               +   VL+  A QI+  M YL ++ F+   HRDL + N L+ E  
Sbjct: 362 NR------------EEVTAVVLLYMATQISSAMEYLEKKNFI---HRDLAARNCLVGE-- 404

Query: 276 EHDDICNKTLKITDFGLAREWHRTTKMSTAGT---YAWMAPEVIKSSLFSKGSDIWSYGV 332
                 N  +K+ DFGL+R     T  + AG      W APE +  + FS  SD+W++GV
Sbjct: 405 ------NHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGV 458

Query: 333 LLWELLT-GEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSF 391
           LLWE+ T G  PY GID L+  Y +      +  P  CP    +LM+ CW+  P  RPSF
Sbjct: 459 LLWEIATYGMSPYPGID-LSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 517

Query: 392 A 392
           A
Sbjct: 518 A 518


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  143 bits (361), Expect = 7e-34
 Identities = 100/301 (33%), Positives = 148/301 (49%), Gaps = 43/301 (14%)

Query: 106 PAPPPSRPS----SPVHVAFER----LELKELIGAGGFGQVYRATWQGQE--VAVKAARQ 155
           PAP  ++P+    SP+H  +E     + +K  +G G +G+VY   W+     VAVK  ++
Sbjct: 262 PAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKE 321

Query: 156 DPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAA 215
           D  +      E   +EA +   ++HPN+++L GVC  +P   +V E+   G L   L   
Sbjct: 322 DTME-----VEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLREC 376

Query: 216 NAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKI 275
           N               +   VL+  A QI+  M YL ++ F+   HRDL + N L+ E  
Sbjct: 377 NR------------EEVTAVVLLYMATQISSAMEYLEKKNFI---HRDLAARNCLVGE-- 419

Query: 276 EHDDICNKTLKITDFGLAREWHRTTKMSTAGT---YAWMAPEVIKSSLFSKGSDIWSYGV 332
                 N  +K+ DFGL+R     T  + AG      W APE +  + FS  SD+W++GV
Sbjct: 420 ------NHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGV 473

Query: 333 LLWELLT-GEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSF 391
           LLWE+ T G  PY GID L+  Y +      +  P  CP    +LM+ CW+  P  RPSF
Sbjct: 474 LLWEIATYGMSPYPGID-LSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 532

Query: 392 A 392
           A
Sbjct: 533 A 533


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  143 bits (361), Expect = 7e-34
 Identities = 100/301 (33%), Positives = 148/301 (49%), Gaps = 43/301 (14%)

Query: 106 PAPPPSRPS----SPVHVAFER----LELKELIGAGGFGQVYRATWQGQE--VAVKAARQ 155
           PAP  ++P+    SP+H  +E     + +K  +G G +G+VY   W+     VAVK  ++
Sbjct: 241 PAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKE 300

Query: 156 DPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAA 215
           D  +      E   +EA +   ++HPN+++L GVC  +P   +V E+   G L   L   
Sbjct: 301 DTME-----VEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLREC 355

Query: 216 NAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKI 275
           N               +   VL+  A QI+  M YL ++ F+   HRDL + N L+ E  
Sbjct: 356 NR------------EEVTAVVLLYMATQISSAMEYLEKKNFI---HRDLAARNCLVGE-- 398

Query: 276 EHDDICNKTLKITDFGLAREWHRTTKMSTAGT---YAWMAPEVIKSSLFSKGSDIWSYGV 332
                 N  +K+ DFGL+R     T  + AG      W APE +  + FS  SD+W++GV
Sbjct: 399 ------NHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGV 452

Query: 333 LLWELLT-GEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSF 391
           LLWE+ T G  PY GID L+  Y +      +  P  CP    +LM+ CW+  P  RPSF
Sbjct: 453 LLWEIATYGMSPYPGID-LSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 511

Query: 392 A 392
           A
Sbjct: 512 A 512


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  143 bits (361), Expect = 7e-34
 Identities = 100/301 (33%), Positives = 148/301 (49%), Gaps = 43/301 (14%)

Query: 106 PAPPPSRPS----SPVHVAFER----LELKELIGAGGFGQVYRATWQGQE--VAVKAARQ 155
           PAP  ++P+    SP+H  +E     + +K  +G G +G+VY   W+     VAVK  ++
Sbjct: 247 PAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKE 306

Query: 156 DPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAA 215
           D  +      E   +EA +   ++HPN+++L GVC  +P   +V E+   G L   L   
Sbjct: 307 DTME-----VEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLREC 361

Query: 216 NAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKI 275
           N               +   VL+  A QI+  M YL ++ F+   HRDL + N L+ E  
Sbjct: 362 NR------------EEVTAVVLLYMATQISSAMEYLEKKNFI---HRDLAARNCLVGE-- 404

Query: 276 EHDDICNKTLKITDFGLAREWHRTTKMSTAGT---YAWMAPEVIKSSLFSKGSDIWSYGV 332
                 N  +K+ DFGL+R     T  + AG      W APE +  + FS  SD+W++GV
Sbjct: 405 ------NHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGV 458

Query: 333 LLWELLT-GEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSF 391
           LLWE+ T G  PY GID L+  Y +      +  P  CP    +LM+ CW+  P  RPSF
Sbjct: 459 LLWEIATYGMSPYPGID-LSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 517

Query: 392 A 392
           A
Sbjct: 518 A 518


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  143 bits (361), Expect = 7e-34
 Identities = 100/301 (33%), Positives = 148/301 (49%), Gaps = 43/301 (14%)

Query: 106 PAPPPSRPS----SPVHVAFER----LELKELIGAGGFGQVYRATWQGQE--VAVKAARQ 155
           PAP  ++P+    SP+H  +E     + +K  +G G +G+VY   W+     VAVK  ++
Sbjct: 226 PAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKE 285

Query: 156 DPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAA 215
           D  +      E   +EA +   ++HPN+++L GVC  +P   +V E+   G L   L   
Sbjct: 286 DTME-----VEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLREC 340

Query: 216 NAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKI 275
           N               +   VL+  A QI+  M YL ++ F+   HRDL + N L+ E  
Sbjct: 341 NR------------EEVTAVVLLYMATQISSAMEYLEKKNFI---HRDLAARNCLVGE-- 383

Query: 276 EHDDICNKTLKITDFGLAREWHRTTKMSTAGT---YAWMAPEVIKSSLFSKGSDIWSYGV 332
                 N  +K+ DFGL+R     T  + AG      W APE +  + FS  SD+W++GV
Sbjct: 384 ------NHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGV 437

Query: 333 LLWELLT-GEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSF 391
           LLWE+ T G  PY GID L+  Y +      +  P  CP    +LM+ CW+  P  RPSF
Sbjct: 438 LLWEIATYGMSPYPGID-LSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 496

Query: 392 A 392
           A
Sbjct: 497 A 497


>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
           [Homo sapiens]
          Length = 762

 Score =  140 bits (353), Expect = 6e-33
 Identities = 107/303 (35%), Positives = 147/303 (48%), Gaps = 30/303 (9%)

Query: 122 ERLELKELIGAGGFGQVYRATWQGQE---------VAVKAARQDPEQDAAAAAESVRREA 172
           +RL L + +G G FGQV RA   G +         VAVK  + +      A   S     
Sbjct: 425 DRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVM 484

Query: 173 RLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANA-APDPRAPGPRRARR 231
           +L    RH NII L GVC Q+  L +++E A  G L   L A     PD    GPR +  
Sbjct: 485 KLIG--RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEG 542

Query: 232 -IPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDF 290
            +   VLV+ A Q+ARGM YL     +   HRDL + N+L+ E        +  +KI DF
Sbjct: 543 PLSFPVLVSCAYQVARGMQYLESRKCI---HRDLAARNVLVTE--------DNVMKIADF 591

Query: 291 GLAREWHRTT--KMSTAGTYA--WMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYR 345
           GLAR  H     K ++ G     WMAPE +   +++  SD+WS+G+LLWE+ T G  PY 
Sbjct: 592 GLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYP 651

Query: 346 GIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAV 405
           GI  +   + +      +  P  CP     LM+ECW   P  RP+F  ++E L  +  AV
Sbjct: 652 GIP-VEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAV 710

Query: 406 MTE 408
             E
Sbjct: 711 SEE 713


>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
           [Homo sapiens]
          Length = 802

 Score =  140 bits (353), Expect = 6e-33
 Identities = 107/303 (35%), Positives = 147/303 (48%), Gaps = 30/303 (9%)

Query: 122 ERLELKELIGAGGFGQVYRATWQGQE---------VAVKAARQDPEQDAAAAAESVRREA 172
           +RL L + +G G FGQV RA   G +         VAVK  + +      A   S     
Sbjct: 465 DRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVM 524

Query: 173 RLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANA-APDPRAPGPRRARR 231
           +L    RH NII L GVC Q+  L +++E A  G L   L A     PD    GPR +  
Sbjct: 525 KLIG--RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEG 582

Query: 232 -IPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDF 290
            +   VLV+ A Q+ARGM YL     +   HRDL + N+L+ E        +  +KI DF
Sbjct: 583 PLSFPVLVSCAYQVARGMQYLESRKCI---HRDLAARNVLVTE--------DNVMKIADF 631

Query: 291 GLAREWHRTT--KMSTAGTYA--WMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYR 345
           GLAR  H     K ++ G     WMAPE +   +++  SD+WS+G+LLWE+ T G  PY 
Sbjct: 632 GLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYP 691

Query: 346 GIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAV 405
           GI  +   + +      +  P  CP     LM+ECW   P  RP+F  ++E L  +  AV
Sbjct: 692 GIP-VEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAV 750

Query: 406 MTE 408
             E
Sbjct: 751 SEE 753


>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
           [Homo sapiens]
          Length = 802

 Score =  140 bits (353), Expect = 6e-33
 Identities = 107/303 (35%), Positives = 147/303 (48%), Gaps = 30/303 (9%)

Query: 122 ERLELKELIGAGGFGQVYRATWQGQE---------VAVKAARQDPEQDAAAAAESVRREA 172
           +RL L + +G G FGQV RA   G +         VAVK  + +      A   S     
Sbjct: 465 DRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVM 524

Query: 173 RLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANA-APDPRAPGPRRARR 231
           +L    RH NII L GVC Q+  L +++E A  G L   L A     PD    GPR +  
Sbjct: 525 KLIG--RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEG 582

Query: 232 -IPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDF 290
            +   VLV+ A Q+ARGM YL     +   HRDL + N+L+ E        +  +KI DF
Sbjct: 583 PLSFPVLVSCAYQVARGMQYLESRKCI---HRDLAARNVLVTE--------DNVMKIADF 631

Query: 291 GLAREWHRTT--KMSTAGTYA--WMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYR 345
           GLAR  H     K ++ G     WMAPE +   +++  SD+WS+G+LLWE+ T G  PY 
Sbjct: 632 GLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYP 691

Query: 346 GIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAV 405
           GI  +   + +      +  P  CP     LM+ECW   P  RP+F  ++E L  +  AV
Sbjct: 692 GIP-VEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAV 750

Query: 406 MTE 408
             E
Sbjct: 751 SEE 753


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score =  138 bits (348), Expect = 2e-32
 Identities = 98/307 (31%), Positives = 147/307 (47%), Gaps = 47/307 (15%)

Query: 99  PCRPAASPAPPPSRPSSPVHVAFER--LELKELIGAGGFGQVYRATWQGQE-VAVKAARQ 155
           PC     PAP      +      +R  ++L + +G+G FG+V+   W     VAVK  + 
Sbjct: 207 PCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKP 266

Query: 156 DPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAA 215
                 +       REA++   LRHP +I+L  VC  +  + ++ E  R G+L   L   
Sbjct: 267 -----GSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQND 321

Query: 216 NAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKI 275
             +            +I     V+ A Q+A GM YL    ++   HRDL + N+L+ E  
Sbjct: 322 TGS------------KIHLTQQVDMAAQVASGMAYLESRNYI---HRDLAARNVLVGE-- 364

Query: 276 EHDDICNKTLKITDFGLAREWHRTTKMSTAGTYA----------WMAPEVIKSSLFSKGS 325
                 +   K+ DFGLAR +    K+     Y           W APE I+S+ FS  S
Sbjct: 365 ------HNIYKVADFGLARVF----KVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKS 414

Query: 326 DIWSYGVLLWELLT-GEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQD 384
           D+WS+G+LL+E++T G++PY G+ G  V   +A N   LP PS CP+ F  +M ECW  +
Sbjct: 415 DVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQN-YRLPQPSNCPQQFYNIMLECWNAE 473

Query: 385 PHIRPSF 391
           P  RP+F
Sbjct: 474 PKERPTF 480



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 32/102 (31%), Positives = 45/102 (44%), Gaps = 21/102 (20%)

Query: 9   ATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRGQLVEVL 68
           +T+   S+    PG   S  S   G         + AL+DY+AR  ++LS R G  ++VL
Sbjct: 20  STEADKSTVIENPGALCSPQSQRHGH-------YFVALFDYQARTAEDLSFRAGDKLQVL 72

Query: 69  SQDAAVSGDEGWW---------AGQVQRRLGIFPANYVAPCR 101
                 +  EGWW          G  Q+  G  P+NYVA  R
Sbjct: 73  D-----TLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDR 109


>gi|18250298 src-related kinase lacking C-terminal regulatory
           tyrosine and N-terminal myristylation sites [Homo
           sapiens]
          Length = 488

 Score =  137 bits (345), Expect = 5e-32
 Identities = 116/381 (30%), Positives = 162/381 (42%), Gaps = 52/381 (13%)

Query: 27  SSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQ 86
           S S+  G S S  A      Y      +  L L++G+L   L +                
Sbjct: 149 SESSLGGYSLSVRAQAKVCHYRVSMAADGSLYLQKGRLFPGLEE---------------- 192

Query: 87  RRLGIFPANYVAPCRPAASPAPPPSRPSSPV-HVAFERLELKELIGAGGFGQVYRATWQG 145
             L  + AN+     P   P  P   P   V         L   +G G FG+V+   W G
Sbjct: 193 -LLTYYKANWKLIQNPLLQPCMPQKAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLG 251

Query: 146 Q-EVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFAR 204
              VA+K  +      A      + +E +    LRH  +I L  VC     + +V E  R
Sbjct: 252 SLPVAIKVIKS-----ANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMR 306

Query: 205 GGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDL 264
            G L   L               RA R+PP  L+ +A Q+A GM YL E+    ++HRDL
Sbjct: 307 KGNLQAFLGTPEG----------RALRLPP--LLGFACQVAEGMSYLEEQR---VVHRDL 351

Query: 265 KSSNILLLEKIEHDDICNKTLKITDFGLAR---EWHRTTKMSTAGTYAWMAPEVIKSSLF 321
            + N+L+      DD      K+ DFGLAR   +   +   S+     W APE     +F
Sbjct: 352 AARNVLV------DD--GLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVF 403

Query: 322 SKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKEC 380
           S+ SD+WS+GVLL E+ T G+ PY G+        + +    LP P+ CP     LM EC
Sbjct: 404 SQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQI-MRGYRLPRPAACPAEVYVLMLEC 462

Query: 381 WQQDPHIRPSFALILEQLTAI 401
           W+  P  RPSFA + E+L AI
Sbjct: 463 WRSSPEERPSFATLREKLHAI 483


>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
          Length = 2347

 Score =  136 bits (342), Expect = 1e-31
 Identities = 100/290 (34%), Positives = 141/290 (48%), Gaps = 30/290 (10%)

Query: 122  ERLELKELIGAGGFGQVYRAT-------WQGQ-EVAVKAARQDPEQDAAAAAESVRREAR 173
            E+L L+ L+G+G FG+VY  T         G+ +VAVK  ++              +EA 
Sbjct: 1943 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKI---EFLKEAH 1999

Query: 174  LFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIP 233
            L +   HPNI++  GVCL      ++LE   GG L   L  A  A      GP     + 
Sbjct: 2000 LMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMAT---FYGPL----LT 2052

Query: 234  PHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLA 293
               LV+  V I++G +YL    F+   HRDL + N L+  K   D    + +KI DFGLA
Sbjct: 2053 LVDLVDLCVDISKGCVYLERMHFI---HRDLAARNCLVSVK---DYTSPRIVKIGDFGLA 2106

Query: 294  REWHRTTKMSTAGT----YAWMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRGID 348
            R+ ++       G       WMAPE +   +F+  SD+WS+G+L+WE+LT G  PY    
Sbjct: 2107 RDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHS 2166

Query: 349  GLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQL 398
             L V   V       P P  CP+    LM +CW Q+P  RP+F  I +QL
Sbjct: 2167 NLDVLNYVQTGGRLEP-PRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQL 2215


>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
          Length = 822

 Score =  136 bits (342), Expect = 1e-31
 Identities = 92/296 (31%), Positives = 143/296 (48%), Gaps = 47/296 (15%)

Query: 119 VAFERLELKELIGAGGFGQVYRATWQGQ-EVAVKAARQDPEQDAAAAAESVRREARLFAM 177
           ++ E + L EL+G G FG+VY+ T + +  VAVK  ++D  Q+         +EA++   
Sbjct: 558 LSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKI---KFLQEAKILKQ 614

Query: 178 LRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVL 237
             HPNI++L GVC Q+  + +++E   GG     L              R+   +    L
Sbjct: 615 YDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLR-------------RKKDELKLKQL 661

Query: 238 VNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWH 297
           V +++  A GMLYL  +  +   HRDL + N L+ E        N  LKI+DFG++R+  
Sbjct: 662 VKFSLDAAAGMLYLESKNCI---HRDLAARNCLVGE--------NNVLKISDFGMSRQ-- 708

Query: 298 RTTKMSTAGTYA----------WMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRG 346
                   G Y+          W APE +    +S  SD+WS+G+LLWE  + G  PY G
Sbjct: 709 -----EDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPG 763

Query: 347 IDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIE 402
           +        V      +  P  CPE  +K+M +CW   P  RP F+ + ++LT I+
Sbjct: 764 MTNQQAREQVE-RGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIK 818


>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
            sapiens]
          Length = 1328

 Score =  135 bits (340), Expect = 2e-31
 Identities = 90/281 (32%), Positives = 137/281 (48%), Gaps = 37/281 (13%)

Query: 128  ELIGAGGFGQVYRA-TWQGQEVAVKAARQDPEQDAAAAAE--SVRREARLFAMLRHPNII 184
            E++G G +G VY   T QGQ +AVK    D     AA  E   ++ E  L   L+H NI+
Sbjct: 1065 EILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 1124

Query: 185  ELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQI 244
               G CLQ+  + + +EF  GG+++  +               R   +P  V   +  QI
Sbjct: 1125 AYLGTCLQENTVSIFMEFVPGGSISSII--------------NRFGPLPEMVFCKYTKQI 1170

Query: 245  ARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLARE--W------ 296
             +G+ YLHE     ++HRD+K +N++L+            +K+ DFG AR   W      
Sbjct: 1171 LQGVAYLHENC---VVHRDIKGNNVMLMP--------TGIIKLIDFGCARRLAWAGLNGT 1219

Query: 297  HRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGV 356
            H     S  GT  WMAPEVI  S + + SDIWS G  ++E+ TG+ P   +D +A  + +
Sbjct: 1220 HSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYI 1279

Query: 357  AVNK-LTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILE 396
              ++ L  P+P    E  A  ++ C  +D H RPS   +L+
Sbjct: 1280 GAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLK 1320


>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
           sapiens]
          Length = 510

 Score =  135 bits (340), Expect = 2e-31
 Identities = 90/281 (32%), Positives = 137/281 (48%), Gaps = 37/281 (13%)

Query: 128 ELIGAGGFGQVYRA-TWQGQEVAVKAARQDPEQDAAAAAE--SVRREARLFAMLRHPNII 184
           E++G G +G VY   T QGQ +AVK    D     AA  E   ++ E  L   L+H NI+
Sbjct: 247 EILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 306

Query: 185 ELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQI 244
              G CLQ+  + + +EF  GG+++  +               R   +P  V   +  QI
Sbjct: 307 AYLGTCLQENTVSIFMEFVPGGSISSII--------------NRFGPLPEMVFCKYTKQI 352

Query: 245 ARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLARE--W------ 296
            +G+ YLHE     ++HRD+K +N++L+            +K+ DFG AR   W      
Sbjct: 353 LQGVAYLHENC---VVHRDIKGNNVMLMP--------TGIIKLIDFGCARRLAWAGLNGT 401

Query: 297 HRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGV 356
           H     S  GT  WMAPEVI  S + + SDIWS G  ++E+ TG+ P   +D +A  + +
Sbjct: 402 HSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYI 461

Query: 357 AVNK-LTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILE 396
             ++ L  P+P    E  A  ++ C  +D H RPS   +L+
Sbjct: 462 GAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLK 502


>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
          Length = 694

 Score =  135 bits (339), Expect = 3e-31
 Identities = 94/287 (32%), Positives = 134/287 (46%), Gaps = 35/287 (12%)

Query: 122 ERLELKELIGAGGFGQVYRATWQGQE--VAVKAARQDPEQDAAAAAESVRREARLFAMLR 179
           E L L E IG G FG+V+    +     VAVK+ R+    D  A      +EAR+     
Sbjct: 431 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKA---KFLQEARILKQYS 487

Query: 180 HPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVN 239
           HPNI+ L GVC Q+  + +V+E  +GG     L    A             R+    L+ 
Sbjct: 488 HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGA-------------RLRVKTLLQ 534

Query: 240 WAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRT 299
                A GM YL  +  +   HRDL + N L+ EK          LKI+DFG++RE    
Sbjct: 535 MVGDAAAGMEYLESKCCI---HRDLAARNCLVTEK--------NVLKISDFGMSREEADG 583

Query: 300 TKMSTAGT----YAWMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVAY 354
              ++ G       W APE +    +S  SD+WS+G+LLWE  + G  PY  +       
Sbjct: 584 VYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTRE 643

Query: 355 GVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAI 401
            V      LP P  CP+   +LM++CW  +P  RPSF+ I ++L +I
Sbjct: 644 FVEKGG-RLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 689


>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
          Length = 752

 Score =  135 bits (339), Expect = 3e-31
 Identities = 94/287 (32%), Positives = 134/287 (46%), Gaps = 35/287 (12%)

Query: 122 ERLELKELIGAGGFGQVYRATWQGQE--VAVKAARQDPEQDAAAAAESVRREARLFAMLR 179
           E L L E IG G FG+V+    +     VAVK+ R+    D  A      +EAR+     
Sbjct: 489 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKA---KFLQEARILKQYS 545

Query: 180 HPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVN 239
           HPNI+ L GVC Q+  + +V+E  +GG     L    A             R+    L+ 
Sbjct: 546 HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGA-------------RLRVKTLLQ 592

Query: 240 WAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRT 299
                A GM YL  +  +   HRDL + N L+ EK          LKI+DFG++RE    
Sbjct: 593 MVGDAAAGMEYLESKCCI---HRDLAARNCLVTEK--------NVLKISDFGMSREEADG 641

Query: 300 TKMSTAGT----YAWMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVAY 354
              ++ G       W APE +    +S  SD+WS+G+LLWE  + G  PY  +       
Sbjct: 642 VYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTRE 701

Query: 355 GVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAI 401
            V      LP P  CP+   +LM++CW  +P  RPSF+ I ++L +I
Sbjct: 702 FVEKGG-RLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 747


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,808,027
Number of Sequences: 37866
Number of extensions: 2382230
Number of successful extensions: 24945
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 791
Number of HSP's successfully gapped in prelim test: 813
Number of HSP's that attempted gapping in prelim test: 16936
Number of HSP's gapped (non-prelim): 5714
length of query: 1036
length of database: 18,247,518
effective HSP length: 112
effective length of query: 924
effective length of database: 14,006,526
effective search space: 12942030024
effective search space used: 12942030024
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.