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Search of human proteins with 154354983
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154354983 regulating synaptic membrane exocytosis 2 isoform
a [Homo sapiens]
(1349 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154354983 regulating synaptic membrane exocytosis 2 isoform a... 2722 0.0
gi|154354981 regulating synaptic membrane exocytosis 2 isoform b... 2191 0.0
gi|41054864 regulating synaptic membrane exocytosis 1 [Homo sapi... 1149 0.0
gi|48476344 regulating synaptic membrane exocytosis 3 [Homo sapi... 346 1e-94
gi|33667061 regulating synaptic membrane exocytosis 4 [Homo sapi... 326 1e-88
gi|150170670 piccolo isoform 2 [Homo sapiens] 143 1e-33
gi|150378539 piccolo isoform 1 [Homo sapiens] 143 1e-33
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide... 71 6e-12
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid... 71 8e-12
gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens] 70 1e-11
gi|193804862 synaptotagmin-like 4 [Homo sapiens] 70 1e-11
gi|193804860 synaptotagmin-like 4 [Homo sapiens] 70 1e-11
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens] 69 2e-11
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens] 69 2e-11
gi|6005997 double C2-like domains, beta [Homo sapiens] 69 2e-11
gi|4506067 protein kinase C, alpha [Homo sapiens] 69 3e-11
gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens] 69 3e-11
gi|244790016 synaptotagmin-like 2 isoform h [Homo sapiens] 69 3e-11
gi|5902064 rabphilin 3A-like (without C2 domains) [Homo sapiens] 68 7e-11
gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens] 67 9e-11
gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens] 67 9e-11
gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens] 67 9e-11
gi|238550198 synaptotagmin III [Homo sapiens] 67 9e-11
gi|238550196 synaptotagmin III [Homo sapiens] 67 9e-11
gi|14150054 synaptotagmin III [Homo sapiens] 67 9e-11
gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens] 66 2e-10
gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens] 66 2e-10
gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens] 66 2e-10
gi|46255068 synaptotagmin-like 2 isoform f [Homo sapiens] 66 2e-10
gi|46255066 synaptotagmin-like 2 isoform e [Homo sapiens] 66 2e-10
>gi|154354983 regulating synaptic membrane exocytosis 2 isoform a
[Homo sapiens]
Length = 1349
Score = 2722 bits (7057), Expect = 0.0
Identities = 1349/1349 (100%), Positives = 1349/1349 (100%)
Query: 1 MSAPVGPRGRLAPIPAASQPPLQPEMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLKK 60
MSAPVGPRGRLAPIPAASQPPLQPEMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLKK
Sbjct: 1 MSAPVGPRGRLAPIPAASQPPLQPEMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLKK 60
Query: 61 LHQQFEMYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFADGCGHNCSYCQTKFCARCG 120
LHQQFEMYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFADGCGHNCSYCQTKFCARCG
Sbjct: 61 LHQQFEMYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFADGCGHNCSYCQTKFCARCG 120
Query: 121 GRVSLRSNKVMWVCNLCRKQQEILTKSGAWFYNSGSNTPQQPDQKVLRGLRNEEAPQEKK 180
GRVSLRSNKVMWVCNLCRKQQEILTKSGAWFYNSGSNTPQQPDQKVLRGLRNEEAPQEKK
Sbjct: 121 GRVSLRSNKVMWVCNLCRKQQEILTKSGAWFYNSGSNTPQQPDQKVLRGLRNEEAPQEKK 180
Query: 181 PKLHEQTQFQGPSGDLSVPAVEKSRSHGLTRQHSIKNGSGVKHHIASDIASDRKRSPSVS 240
PKLHEQTQFQGPSGDLSVPAVEKSRSHGLTRQHSIKNGSGVKHHIASDIASDRKRSPSVS
Sbjct: 181 PKLHEQTQFQGPSGDLSVPAVEKSRSHGLTRQHSIKNGSGVKHHIASDIASDRKRSPSVS 240
Query: 241 RDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSNRRS 300
RDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSNRRS
Sbjct: 241 RDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSNRRS 300
Query: 301 HRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQMRIHAEVS 360
HRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQMRIHAEVS
Sbjct: 301 HRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQMRIHAEVS 360
Query: 361 RARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTREAQG 420
RARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTREAQG
Sbjct: 361 RARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTREAQG 420
Query: 421 PSSYAQRTTNHSPPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAVRKTKREKMETMLRN 480
PSSYAQRTTNHSPPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAVRKTKREKMETMLRN
Sbjct: 421 PSSYAQRTTNHSPPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAVRKTKREKMETMLRN 480
Query: 481 DSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVEIESESVSE 540
DSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVEIESESVSE
Sbjct: 481 DSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVEIESESVSE 540
Query: 541 KGDMDYNWLDHTSWHSSEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAM 600
KGDMDYNWLDHTSWHSSEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAM
Sbjct: 541 KGDMDYNWLDHTSWHSSEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAM 600
Query: 601 LGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNI 660
LGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNI
Sbjct: 601 LGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNI 660
Query: 661 ILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVTSPMSPGML 720
ILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVTSPMSPGML
Sbjct: 661 ILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVTSPMSPGML 720
Query: 721 RDVPQFLSGQLSSQSLSRRTTPFVPRVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRN 780
RDVPQFLSGQLSSQSLSRRTTPFVPRVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRN
Sbjct: 721 RDVPQFLSGQLSSQSLSRRTTPFVPRVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRN 780
Query: 781 PYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVR 840
PYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVR
Sbjct: 781 PYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVR 840
Query: 841 EEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQ 900
EEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQ
Sbjct: 841 EEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQ 900
Query: 901 RSKRISDSEVSDYDCDDGIGVVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDV 960
RSKRISDSEVSDYDCDDGIGVVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDV
Sbjct: 901 RSKRISDSEVSDYDCDDGIGVVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDV 960
Query: 961 IGRTRSWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPDRDRDCEAA 1020
IGRTRSWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPDRDRDCEAA
Sbjct: 961 IGRTRSWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPDRDRDCEAA 1020
Query: 1021 DRQPYHRSRSTEQRPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHPRT 1080
DRQPYHRSRSTEQRPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHPRT
Sbjct: 1021 DRQPYHRSRSTEQRPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHPRT 1080
Query: 1081 GSVQTSPSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTR 1140
GSVQTSPSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTR
Sbjct: 1081 GSVQTSPSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTR 1140
Query: 1141 QASRESTDGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQ 1200
QASRESTDGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQ
Sbjct: 1141 QASRESTDGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQ 1200
Query: 1201 VGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPL 1260
VGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPL
Sbjct: 1201 VGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPL 1260
Query: 1261 YQQLLSFEESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSS 1320
YQQLLSFEESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSS
Sbjct: 1261 YQQLLSFEESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSS 1320
Query: 1321 LVDPTLAPLTRRASQSSLESSTGPSYSRS 1349
LVDPTLAPLTRRASQSSLESSTGPSYSRS
Sbjct: 1321 LVDPTLAPLTRRASQSSLESSTGPSYSRS 1349
>gi|154354981 regulating synaptic membrane exocytosis 2 isoform b
[Homo sapiens]
Length = 1163
Score = 2191 bits (5676), Expect = 0.0
Identities = 1101/1139 (96%), Positives = 1101/1139 (96%), Gaps = 38/1139 (3%)
Query: 233 RKRSPSVSRDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLS 292
RKRSPSVSRDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLS
Sbjct: 41 RKRSPSVSRDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLS 100
Query: 293 YRDSNRRSHRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQ 352
YRDSNRRSHRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQ
Sbjct: 101 YRDSNRRSHRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQ 160
Query: 353 MRIHAEVSRARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSM 412
MRIHAEVSRARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSM
Sbjct: 161 MRIHAEVSRARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSM 220
Query: 413 ERTREAQGPSSYAQRTTNHSPPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAVRKTKRE 472
ERTREAQGPSSYAQRTTNHSPPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAVRKTKRE
Sbjct: 221 ERTREAQGPSSYAQRTTNHSPPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAVRKTKRE 280
Query: 473 KMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVE 532
KMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVE
Sbjct: 281 KMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVE 340
Query: 533 IESESVSEKGDMDYNWLDHTSWHSSEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGS 592
IESESVSEKGDMDYNWLDHTSWHSSEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGS
Sbjct: 341 IESESVSEKGDMDYNWLDHTSWHSSEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGS 400
Query: 593 VPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGA 652
VPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGA
Sbjct: 401 VPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGA 460
Query: 653 TFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVT 712
TFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVT
Sbjct: 461 TFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVT 520
Query: 713 SPMSPGMLRDVPQFLSGQLSSQSLSRRTTPFVPRVQIKLWFDKVGHQLIVTILGAKDLPS 772
SPMSPGMLRDVPQFLSGQLS IKLWFDKVGHQLIVTILGAKDLPS
Sbjct: 521 SPMSPGMLRDVPQFLSGQLS----------------IKLWFDKVGHQLIVTILGAKDLPS 564
Query: 773 REDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEIT 832
REDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEIT
Sbjct: 565 REDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEIT 624
Query: 833 LWDQARVREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHG 892
LWDQARVREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHG
Sbjct: 625 LWDQARVREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHG 684
Query: 893 ESPTRRLQRSKRISDSEVSDYDCDDGIGVVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPS 952
ESPTRRLQRSKRISDSEVSDYDCDDGIGVVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPS
Sbjct: 685 ESPTRRLQRSKRISDSEVSDYDCDDGIGVVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPS 744
Query: 953 GSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPD 1012
GSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPD
Sbjct: 745 GSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPD 804
Query: 1013 RD----------------------RDCEAADRQPYHRSRSTEQRPLLERTTTRSRSTERP 1050
RD RDCEAADRQPYHRSRSTEQRPLLERTTTRSRSTERP
Sbjct: 805 RDSHFLTLPRSRYSQTIDHHHRDGRDCEAADRQPYHRSRSTEQRPLLERTTTRSRSTERP 864
Query: 1051 DTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSSTPVAGRRGRQLPQLPPKGTLD 1110
DTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSSTPVAGRRGRQLPQLPPKGTLD
Sbjct: 865 DTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSSTPVAGRRGRQLPQLPPKGTLD 924
Query: 1111 RKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVRLASD 1170
RKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVRLASD
Sbjct: 925 RKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVRLASD 984
Query: 1171 SQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLP 1230
SQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLP
Sbjct: 985 SQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLP 1044
Query: 1231 APYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMDHK 1290
APYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMDHK
Sbjct: 1045 APYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMDHK 1104
Query: 1291 SFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSRS 1349
SFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSRS
Sbjct: 1105 SFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSRS 1163
>gi|41054864 regulating synaptic membrane exocytosis 1 [Homo sapiens]
Length = 1692
Score = 1149 bits (2971), Expect = 0.0
Identities = 629/1087 (57%), Positives = 761/1087 (70%), Gaps = 109/1087 (10%)
Query: 1 MSAPVGPRGRLAPIPAASQPPLQPEMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLK- 59
MS+ VGPRG P P PP+Q E+PDLSHLTEEER II+AVMDRQK+EEEKE+++LK
Sbjct: 1 MSSAVGPRG---PRPPTVPPPMQ-ELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKC 56
Query: 60 --------------------------KLHQQFEMYKEQVKKMGEESQQQQ-EQKGDAPTC 92
+LHQQFE YKEQV+K+GEE+++ Q E K DAPTC
Sbjct: 57 VVRDMAKPAACKTPRNAENQPHQPSPRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTC 116
Query: 93 GICHKTKFADGCGHNCSYCQTKFCARCGGRVSLRSNK----VMWVCNLCRKQQEILTKSG 148
GICHKTKFADGCGH CSYC+TKFCARCGGRVSLRSN VMWVCNLCRKQQEILTKSG
Sbjct: 117 GICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKSG 176
Query: 149 AWFYNSGSNTPQQPDQK-----VLRGLRNEEAPQEKKPKLHEQTQFQGP-------SGDL 196
AWF+ SG PQQ Q G E P+EKK +L E+++ Q P S D
Sbjct: 177 AWFFGSG---PQQTSQDGTLSDTATGA-GSEVPREKKARLQERSRSQTPLSTAAASSQDA 232
Query: 197 SVPAVEKSRSHGL--TRQHSIKNGSGVKHHIASDIASDRKRSPSVSRDQNRRYDQREERE 254
+ P+ RS G ++Q S+ +RK++P +S +QN + + ER+
Sbjct: 233 APPSAPPDRSKGAEPSQQALGPEQKQASSRSRSEPPRERKKTPGLS-EQNGKGALKSERK 291
Query: 255 EYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSNRRSHRHSKEYIVDDEDV 314
+P++ + + E+ + R+S R S++Y +
Sbjct: 292 R----------VPKTSAQPVEGA-------VEERERKERRESRRLEKGRSQDY---PDTP 331
Query: 315 ESRDE-----YERQRREEEYQSRYRSDPNLARYPVKPQPYEEQMRIHAEVSRARHERRHS 369
E RDE E+QR+EE+YQ+RYRSDPNLARYPVKP P E+QMR+HA VSRARHERRHS
Sbjct: 332 EKRDEGKAADEEKQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHS 391
Query: 370 DVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTREAQGPSSYAQRTT 429
DV+L + + L + ++ + R + ++ R+YS ERT E + P A++ T
Sbjct: 392 DVALPRTEAG----AALPEGKAGKRAPAAARASPPDSPRAYSAERTAETRAPG--AKQLT 445
Query: 430 NHSPPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAV--RKTKREKMETMLRNDSLSSDQ 487
NHSPP PR P+P + P+L+ + LRKQ LDPSSAV RK KREK+ETMLRNDSLSSDQ
Sbjct: 446 NHSPPAPRHGPVPAEAPELKAQEPLRKQSRLDPSSAVLMRKAKREKVETMLRNDSLSSDQ 505
Query: 488 SESVRPPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVEIESESVSEKGDMDYN 547
SESVRP PPKPH+SK+GGK RQ+S+SSSEEE STPEYTSC+DVE+ESESVSEKGD+DY
Sbjct: 506 SESVRPSPPKPHRSKRGGKKRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYY 565
Query: 548 WLDHTSWHSSEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVG 607
WLD +WHS E SP+S HPVTWQPSK+GDRLIGR++LNKR ++P+DSGA+LGLKVVG
Sbjct: 566 WLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRT---TMPKDSGALLGLKVVG 622
Query: 608 GKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNIILESKPE 667
GKMT+ GRL AFITKVKKGSLAD VGHLR GDEVLEWNG+ L GAT EEVYNIILESK E
Sbjct: 623 GKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSE 682
Query: 668 PQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFL 727
PQVE++VSRPIGDIPRIP+S+H LESSSSSFESQKM+RPSISV SP SPG L+D PQ L
Sbjct: 683 PQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVL 742
Query: 728 SGQLSSQSLSRRTTPFVPRVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYF 787
GQLS +KLW+DKVGHQLIV +L A DLP+R DGRPRNPYVK+YF
Sbjct: 743 PGQLS----------------VKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYF 786
Query: 788 LPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFL 847
LPDRSDK+KRRTKTVKK LEPKWNQTF+YS VHRR+FRERMLEIT+WDQ RV+EEESEFL
Sbjct: 787 LPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFL 846
Query: 848 GEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQRSKRISD 907
GEILIELETALLDDEPHWYKLQTHD SSLPLP PSP+MPRR +HGES +++LQRS+RISD
Sbjct: 847 GEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHIHGESSSKKLQRSQRISD 906
Query: 908 SEVSDYDCDDGIGVVS--DYRHDGRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDVIGRTR 965
S++SDY+ DDGIGVV YR R+ +S+TL+VPEQ +++H S S SPHR + G+ R
Sbjct: 907 SDISDYEVDDGIGVVPPVGYRSSARESKSTTLTVPEQQRTTHHRSRSVSPHRGNDQGKPR 966
Query: 966 SWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPDRDRDCEAADRQPY 1025
S P+VP +S + R +R+ T H++ HR D ++D E
Sbjct: 967 SRLPNVPLQRSLDEIHPTRRSRSPTRHHDASRSPVDHRTRDVDSQYLSEQDSELLMLPRA 1026
Query: 1026 HRSRSTE 1032
R RS E
Sbjct: 1027 KRGRSAE 1033
Score = 404 bits (1037), Expect = e-112
Identities = 226/377 (59%), Positives = 262/377 (69%), Gaps = 38/377 (10%)
Query: 1000 DRHRVMDDHYSPDRDRDCEAADRQPYHRSRSTEQRPLLERTTTRSRSTERPDTNLMRSMP 1059
D++R D+ + D D +D R+ S + L T+ S +ERP + P
Sbjct: 1327 DQYRSCDNVSAKSSDSD--VSDVSAISRTSSASR---LSSTSFMSEQSERPRGRISSFTP 1381
Query: 1060 SLMTGRSAPPSPALSRSHPRTGSVQT------SPSSTPVA-------------------- 1093
+ R ++ +S +G + T S S T V
Sbjct: 1382 KMQGRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAI 1441
Query: 1094 -GRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMN 1152
RR R QL ++G KKL+ST+QRSTETG+A EMR M RQ SRESTDGS+N
Sbjct: 1442 VSRRSRSTSQLS-----QTESGHKKLKSTIQRSTETGMAAEMRK-MVRQPSRESTDGSIN 1495
Query: 1153 SYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEV 1212
SYSSEGNLIFPGVRL +DSQFSDFLDGLGPAQLVGRQTLATPAMGDIQ+GM DKKGQLEV
Sbjct: 1496 SYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEV 1555
Query: 1213 EIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQ 1272
E+IRAR L KPGSK+ PAPYVKVYLL+NG CIAKKKT++ARKTL+PLYQQ L F+ESPQ
Sbjct: 1556 EVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQ 1615
Query: 1273 GKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRR 1332
GKVLQ+IVWGDYGRMDHK FMGVAQILL+EL+LS+MVIGW+KLFPPSSLVDPTL PLTRR
Sbjct: 1616 GKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRR 1675
Query: 1333 ASQSSLESSTGPSYSRS 1349
ASQSSLESSTGP RS
Sbjct: 1676 ASQSSLESSTGPPCIRS 1692
Score = 67.0 bits (162), Expect = 1e-10
Identities = 40/127 (31%), Positives = 58/127 (45%), Gaps = 25/127 (19%)
Query: 1003 RVMDDHYSPDRDRDCEAADRQPYHRS-------------------------RSTEQRPLL 1037
R+ H SP+ DR ++R + R+T+Q +
Sbjct: 1149 RIQIQHASPENDRHSRKSERSSIQKQTRKGTASDAERVLPTCLSRRGHAAPRATDQPVIR 1208
Query: 1038 ERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSSTPVAGRRG 1097
+ RSRS+E + SM L+ G SAPPSP L+R H + Q+ P+ T + RRG
Sbjct: 1209 GKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPADTSFSSRRG 1268
Query: 1098 RQLPQLP 1104
RQLPQ+P
Sbjct: 1269 RQLPQVP 1275
Score = 57.8 bits (138), Expect = 7e-08
Identities = 134/562 (23%), Positives = 224/562 (39%), Gaps = 89/562 (15%)
Query: 370 DVSLANADLEDSRIS-MLRMDRPSRQRSISERRAAMENQR-SYSMERT----REAQGPSS 423
D SL + + E R S L RP R I + A+ EN R S ER+ + +G +S
Sbjct: 1123 DTSLHSPERERGRWSPSLDRRRPPSPR-IQIQHASPENDRHSRKSERSSIQKQTRKGTAS 1181
Query: 424 YAQRT-----TNHSPPTPRRSPLPIDR---PDLRRTD------SLRKQHHL------DPS 463
A+R + PR + P+ R P R+ +L HHL PS
Sbjct: 1182 DAERVLPTCLSRRGHAAPRATDQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPS 1241
Query: 464 SAVRKTKREKMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEE------ 517
+ + R++ T S +D S S R P + G + Q SL E
Sbjct: 1242 PLLTRMHRQRSPTQ----SPPADTSFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKM 1297
Query: 518 ---ELASTPEYTSCDDVEIESESVSEKGDMDYNWLDHTSWHSSEASPMSLHPVTWQPSKD 574
T S +++ E S Y D+ S SS++ + ++ S
Sbjct: 1298 KVHRFKQTTGSGSSQELDREQYSKYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSS-- 1355
Query: 575 GDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVK---------K 625
RL ++++ + PR + K+ G +M SGR T V
Sbjct: 1356 ASRLSSTSFMSEQSER---PRGRISSFTPKMQGRRMGTSGRSIMKSTSVSGEMYTLEHND 1412
Query: 626 GSLADT-VGHLRPGDE------------VLEWNGRLLQGATFEEVYNIILESKPEPQVEL 672
GS +DT VG + G + ++ R + E + L+S + E
Sbjct: 1413 GSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTET 1472
Query: 673 VVSRPIGDIPRIP--DSTHAQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQ 730
++ + + R P +ST + S SS + P + + G FL G
Sbjct: 1473 GMAAEMRKMVRQPSRESTDGSINSYSSE---GNLIFPGVRL------GADSQFSDFLDGL 1523
Query: 731 LSSQSLSRRT--TPFVPRVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRN-PYVKIYF 787
+Q + R+T TP + +QI + DK G QL V ++ A+ L + + PYVK+Y
Sbjct: 1524 GPAQLVGRQTLATPAMGDIQIGME-DKKG-QLEVEVIRARSLTQKPGSKSTPAPYVKVYL 1581
Query: 788 LPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLW-DQARVREEESEF 846
L + + K++T+ +KTL+P + Q+ ++ + ++L++ +W D R+ +
Sbjct: 1582 LENGACIAKKKTRIARKTLDPLYQQSLVFD----ESPQGKVLQVIVWGDYGRMDHKCFMG 1637
Query: 847 LGEILIELETALLDDEPHWYKL 868
+ +IL+E E L WYKL
Sbjct: 1638 VAQILLE-ELDLSSMVIGWYKL 1658
Score = 43.9 bits (102), Expect = 0.001
Identities = 41/136 (30%), Positives = 67/136 (49%), Gaps = 10/136 (7%)
Query: 1205 DKKG-QLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQ 1263
DK G QL V +++A L + + PYVK+Y L + +K++TK +K LEP + Q
Sbjct: 753 DKVGHQLIVNVLQATDLPARVDGRPRN-PYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQ 811
Query: 1264 LLSF----EESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLD-ELELSNMVIGWFKL--F 1316
+ + ++L+I VW D R+ + + +IL++ E L + W+KL
Sbjct: 812 TFVYSHVHRRDFRERMLEITVW-DQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTH 870
Query: 1317 PPSSLVDPTLAPLTRR 1332
SSL P +P R
Sbjct: 871 DESSLPLPQPSPFMPR 886
Score = 32.3 bits (72), Expect = 3.2
Identities = 32/114 (28%), Positives = 47/114 (41%), Gaps = 23/114 (20%)
Query: 1031 TEQRPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSST 1090
+E +P L+R + S + RPDT+L P GR SP+L R P + +Q +S
Sbjct: 1103 SELQPFLDRARSASTNCLRPDTSL--HSPERERGRW---SPSLDRRRPPSPRIQIQHAS- 1156
Query: 1091 PVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASR 1144
P R R K RS++Q+ T G A + + SR
Sbjct: 1157 PENDRHSR-----------------KSERSSIQKQTRKGTASDAERVLPTCLSR 1193
>gi|48476344 regulating synaptic membrane exocytosis 3 [Homo sapiens]
Length = 308
Score = 346 bits (887), Expect = 1e-94
Identities = 173/249 (69%), Positives = 203/249 (81%), Gaps = 8/249 (3%)
Query: 1099 QLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEG 1158
QLPQ P+G KKLRS ++RSTETG+AVEMR+ +TRQ SRESTDGS NS SS+G
Sbjct: 68 QLPQ--PEGAT------KKLRSNIRRSTETGIAVEMRSRVTRQGSRESTDGSTNSNSSDG 119
Query: 1159 NLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRAR 1218
IFP RL ++SQFSDFLDGLGPAQ+VGRQTLATP MGD+ + +MD+ GQLEVE+I AR
Sbjct: 120 TFIFPTTRLGAESQFSDFLDGLGPAQIVGRQTLATPPMGDVHIAIMDRSGQLEVEVIEAR 179
Query: 1219 GLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQI 1278
GL KPGSK+LPA Y+KVYLL+NG C+AKKKTK+ +KT +PLYQQ L F+E PQGKVLQ+
Sbjct: 180 GLTPKPGSKSLPATYIKVYLLENGACLAKKKTKMTKKTCDPLYQQALLFDEGPQGKVLQV 239
Query: 1279 IVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSL 1338
IVWGDYGRMDHK FMG+AQI+LDEL+LS V GW+KLFP SS+ D TL LTRR SQSSL
Sbjct: 240 IVWGDYGRMDHKCFMGMAQIMLDELDLSAAVTGWYKLFPTSSVADSTLGSLTRRLSQSSL 299
Query: 1339 ESSTGPSYS 1347
ES+T PS S
Sbjct: 300 ESATSPSCS 308
Score = 46.6 bits (109), Expect = 2e-04
Identities = 43/178 (24%), Positives = 79/178 (44%), Gaps = 9/178 (5%)
Query: 693 ESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSSQSLSRRTTPFVPRVQIKLW 752
ES+ S S D I T+ + G FL G +Q + R+T P + +
Sbjct: 106 ESTDGSTNSNSSDGTFIFPTTRL--GAESQFSDFLDGLGPAQIVGRQTLATPPMGDVHIA 163
Query: 753 FDKVGHQLIVTILGAKDLPSREDGRPRNP-YVKIYFLPDRSDKNKRRTKTVKKTLEPKWN 811
QL V ++ A+ L + + Y+K+Y L + + K++TK KKT +P +
Sbjct: 164 IMDRSGQLEVEVIEARGLTPKPGSKSLPATYIKVYLLENGACLAKKKTKMTKKTCDPLYQ 223
Query: 812 QTFIYSPVHRREFRERMLEITLW-DQARVREEESEFLGEILIELETALLDDEPHWYKL 868
Q ++ + ++L++ +W D R+ + + +I+++ E L WYKL
Sbjct: 224 QALLFD----EGPQGKVLQVIVWGDYGRMDHKCFMGMAQIMLD-ELDLSAAVTGWYKL 276
>gi|33667061 regulating synaptic membrane exocytosis 4 [Homo sapiens]
Length = 269
Score = 326 bits (835), Expect = 1e-88
Identities = 159/241 (65%), Positives = 196/241 (81%), Gaps = 1/241 (0%)
Query: 1110 DRKAG-GKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVRLA 1168
D AG ++L+ +QRSTETGLAVEM + RQAS ES + SMNSY SEGNL + GV LA
Sbjct: 29 DEDAGDSRRLKGAIQRSTETGLAVEMPSRTLRQASHESIEDSMNSYGSEGNLNYGGVCLA 88
Query: 1169 SDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKT 1228
SD+QFSDFL +GPAQ VGRQTLAT MGD+++G+ ++ GQLEV+II+ARGL KPGSKT
Sbjct: 89 SDAQFSDFLGSMGPAQFVGRQTLATTPMGDVEIGLQERNGQLEVDIIQARGLTAKPGSKT 148
Query: 1229 LPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMD 1288
LPA Y+K YLL+NG+CIAKKKTKVARK+L+PLY Q+L F ESPQGKVLQ+IVWG+YGRM+
Sbjct: 149 LPAAYIKAYLLENGICIAKKKTKVARKSLDPLYNQVLLFPESPQGKVLQVIVWGNYGRME 208
Query: 1289 HKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSR 1348
K FMGVA++LL+EL+L+ + +GW+KLFP SS+VDP PL R+ASQ SLES+ GP R
Sbjct: 209 RKQFMGVARVLLEELDLTTLAVGWYKLFPTSSMVDPATGPLLRQASQLSLESTVGPCGER 268
Query: 1349 S 1349
S
Sbjct: 269 S 269
Score = 51.2 bits (121), Expect = 7e-06
Identities = 50/205 (24%), Positives = 94/205 (45%), Gaps = 22/205 (10%)
Query: 687 STHAQLESSSSSFESQ-KMDRPSISVTSPMSPGMLRDVPQFLSGQLSSQSLSRRTTPFVP 745
++H +E S +S+ S+ ++ + + S FL +Q + R+T P
Sbjct: 62 ASHESIEDSMNSYGSEGNLNYGGVCLASDAQ------FSDFLGSMGPAQFVGRQTLATTP 115
Query: 746 RVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNP-YVKIYFLPDRSDKNKRRTKTVKK 804
+++ + QL V I+ A+ L ++ + Y+K Y L + K++TK +K
Sbjct: 116 MGDVEIGLQERNGQLEVDIIQARGLTAKPGSKTLPAAYIKAYLLENGICIAKKKTKVARK 175
Query: 805 TLEPKWNQTFIY--SPVHRREFRERMLEITLWDQARVREEESEFLG--EILIELETALLD 860
+L+P +NQ ++ SP + ++L++ +W R E +F+G +L+E E L
Sbjct: 176 SLDPLYNQVLLFPESP------QGKVLQVIVWGNYG-RMERKQFMGVARVLLE-ELDLTT 227
Query: 861 DEPHWYKLQTHDVSSLPLPHPSPYM 885
WYKL SS+ P P +
Sbjct: 228 LAVGWYKL--FPTSSMVDPATGPLL 250
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 143 bits (361), Expect = 1e-33
Identities = 117/375 (31%), Positives = 185/375 (49%), Gaps = 69/375 (18%)
Query: 581 RILLNKRLKDGSVPRDSGAMLGLKVVGGKMT--ESGRLCAFITKVKKGSLADTVGHLRPG 638
RI + + KD +V SG LG+++VGGK SG + A+I K+ G A+ G L G
Sbjct: 4496 RIKITRDSKDHTV---SGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEQTGKLMEG 4552
Query: 639 DEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSS 698
+VLEWNG L T+EEV +II S+ + E+ V + + +S H +L +
Sbjct: 4553 MQVLEWNGIPLTSKTYEEVQSII--SQQSGEAEICVRLDLNMLSDSENSQHLELHEPPKA 4610
Query: 699 FESQK---MDRPSIS-----VTSPMSPGMLRDVPQFLS-----------------GQLSS 733
+ K +D ++ V+ SP +L V + S GQ S
Sbjct: 4611 VDKAKSPGVDPKQLAAELQKVSLQQSPLVLSSVVEKGSHVHSGPTSAGSSSVPSPGQPGS 4670
Query: 734 QSLSRR--------------TTPFVPRVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPR 779
S+S++ + P +Q+++ +D +G+ LI+ IL A++L R++
Sbjct: 4671 PSVSKKKHGSSKPTDGTKVVSHPITGEIQLQINYD-LGN-LIIHILQARNLVPRDNNGYS 4728
Query: 780 NPYVKIYFLPDR---------SDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLE 830
+P+VK+Y LP R S + KRRTK V+K+L P+WNQT IY + + +++ LE
Sbjct: 4729 DPFVKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLE 4788
Query: 831 ITLWDQARVREEESEFLGEILIEL-ETALLDDEPHWYKL--QTHDV-------SSLPLPH 880
+T+WD R ++FLGE+LI+L T+ LD+ P WY L QT + S
Sbjct: 4789 VTVWDYDRF--SSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQSSQQS 4846
Query: 881 PSPYMPRRQLHGESP 895
P P + + + HG P
Sbjct: 4847 PKPSVIKSRSHGIFP 4861
Score = 57.0 bits (136), Expect = 1e-07
Identities = 50/176 (28%), Positives = 82/176 (46%), Gaps = 20/176 (11%)
Query: 1187 GRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLL------- 1239
G + ++ P G+IQ+ + G L + I++AR LV + + P+VKVYLL
Sbjct: 4686 GTKVVSHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNG-YSDPFVKVYLLPGRGQVM 4744
Query: 1240 --DNGVCIAKKKTKVARKTLEPLYQQLLSFE----ESPQGKVLQIIVWGDYGRMDHKSFM 1293
N K++TK +K+L P + Q + ++ E + K L++ VW DY R F+
Sbjct: 4745 VVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVW-DYDRFSSNDFL 4803
Query: 1294 GVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSRS 1349
G I L + W+ L + +D + +SQSS + S PS +S
Sbjct: 4804 GEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKS----HSSQSS-QQSPKPSVIKS 4854
Score = 34.3 bits (77), Expect = 0.83
Identities = 42/170 (24%), Positives = 65/170 (38%), Gaps = 35/170 (20%)
Query: 6 GPRGRLAPIPAASQPPLQ----------PEMPDLSHLTEEERKIILAVMDRQKKEEEKEQ 55
GP + PA SQPP P P S ++E K A +K E + EQ
Sbjct: 959 GPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAA----EKLEPKAEQ 1014
Query: 56 SVLKKLHQQFEMYKEQVKKMGEESQQQQEQKGDAP-----------TCGICHKTKFADGC 104
+ K + E K+ +S + QK P TC +C KT+ G
Sbjct: 1015 APTVK---RTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLC-KTELNIGS 1070
Query: 105 G-----HNCSYCQTKFCARCGGRVSLRSNKVM-WVCNLCRKQQEILTKSG 148
+ C+ C+ + C CG + ++ W+C C+ Q+ I + G
Sbjct: 1071 KDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLG 1120
Score = 32.7 bits (73), Expect = 2.4
Identities = 41/204 (20%), Positives = 76/204 (37%), Gaps = 14/204 (6%)
Query: 241 RDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSNRRS 300
+ +R + R +Y + T PRS D Q + + D ++S R ++S
Sbjct: 3408 KQPKKRSSGAKVRGQYDDMGENMTDDPRSFKKIVDSGVQTDDEDATDRSYVSRRRRTKKS 3467
Query: 301 HRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQMRIHAEVS 360
S + DDED + D R RR+ +Y A K +P + I +
Sbjct: 3468 VDTSVQ--TDDEDQDEWDMPTRSRRKARV-GKYGDSMTEAD---KTKPLSKVSSIAVQTV 3521
Query: 361 RARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTREAQG 420
+++S+ + R +R ++ I A + + S+ EA
Sbjct: 3522 --------AEISVQTEPVGTIRTPSIRARVDAKVEIIKHISAPEKTYKGGSLGCQTEADS 3573
Query: 421 PSSYAQRTTNHSPPTPRRSPLPID 444
+ Q + SPP ++ P P++
Sbjct: 3574 DTQSPQYLSATSPPKDKKRPTPLE 3597
Score = 31.6 bits (70), Expect = 5.4
Identities = 49/261 (18%), Positives = 92/261 (35%), Gaps = 41/261 (15%)
Query: 15 PAASQPPLQ--------PEMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLKKLHQQFE 66
P +++PP Q P+ P + ++ + + Q K + Q
Sbjct: 504 PGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGS 563
Query: 67 MYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFA-----DGCGHNCSYCQTKFCARCGG 121
Q + ++Q Q C +C+ T+ + C+ CQT C+ CG
Sbjct: 564 GKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGF 623
Query: 122 RVSLRSNKVM-WVCNLCRKQQEI-------------------LTKSGAWFYNSGSNTPQQ 161
+ +V W+C C+ ++ + +T + A + S PQQ
Sbjct: 624 NPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSA--VSKSSPQPQQ 681
Query: 162 PDQKVLRGLRNE--EAPQEKK-PKLHEQTQFQGPSGDLSVPAVEKSRSHGLTRQHSIKNG 218
K + + +AP+ KK P L +Q G S A + + L++ K
Sbjct: 682 TSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSP---SAKAKQPPEADSLSKPAPPKEP 738
Query: 219 SGVKHHIASDIASDRKRSPSV 239
S + +A D+ + P +
Sbjct: 739 SVPSEQDKAPVADDKPKQPKM 759
Score = 31.6 bits (70), Expect = 5.4
Identities = 20/84 (23%), Positives = 39/84 (46%), Gaps = 12/84 (14%)
Query: 3 APVGPRGRLAPIPAASQPPLQPEMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLKKLH 62
AP GP+ P+P S P + + ++E+++ + E E+ +L+K+
Sbjct: 1128 APSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEV----------KTEAEKVILEKVK 1177
Query: 63 QQFEMYKEQVKKMGEESQQQQEQK 86
+ M E++ M Q+Q+E K
Sbjct: 1178 ETLSM--EKIPPMVTTDQKQEESK 1199
Score = 31.6 bits (70), Expect = 5.4
Identities = 39/183 (21%), Positives = 74/183 (40%), Gaps = 21/183 (11%)
Query: 178 EKKPKLHEQTQFQGPSGDLSVPAVEKSRSHGLTRQHSIKNGSGVKHHIASDIASDRKRSP 237
+KK L+ + + L+ ++SR G + H+ G S + D SP
Sbjct: 1686 QKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSP 1745
Query: 238 SVSRDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSN 297
S + ++++ QR+ R P P S E + E+ + L ++
Sbjct: 1746 SHKKGESKQ--QRKARHR-----------PHGPLLPTIEDSSEEEELREEEELLKEQEKQ 1792
Query: 298 RRSHRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDP-NLARYPVKPQPYEEQMRIH 356
R + ++ + + +DE QRR E R ++ P NL+ P++ E++R
Sbjct: 1793 REIEQQQRK-SSSKKSKKDKDELRAQRRRE----RPKTPPSNLS--PIEDASPTEELRQA 1845
Query: 357 AEV 359
AE+
Sbjct: 1846 AEM 1848
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 143 bits (361), Expect = 1e-33
Identities = 117/375 (31%), Positives = 185/375 (49%), Gaps = 69/375 (18%)
Query: 581 RILLNKRLKDGSVPRDSGAMLGLKVVGGKMT--ESGRLCAFITKVKKGSLADTVGHLRPG 638
RI + + KD +V SG LG+++VGGK SG + A+I K+ G A+ G L G
Sbjct: 4496 RIKITRDSKDHTV---SGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEQTGKLMEG 4552
Query: 639 DEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSS 698
+VLEWNG L T+EEV +II S+ + E+ V + + +S H +L +
Sbjct: 4553 MQVLEWNGIPLTSKTYEEVQSII--SQQSGEAEICVRLDLNMLSDSENSQHLELHEPPKA 4610
Query: 699 FESQK---MDRPSIS-----VTSPMSPGMLRDVPQFLS-----------------GQLSS 733
+ K +D ++ V+ SP +L V + S GQ S
Sbjct: 4611 VDKAKSPGVDPKQLAAELQKVSLQQSPLVLSSVVEKGSHVHSGPTSAGSSSVPSPGQPGS 4670
Query: 734 QSLSRR--------------TTPFVPRVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPR 779
S+S++ + P +Q+++ +D +G+ LI+ IL A++L R++
Sbjct: 4671 PSVSKKKHGSSKPTDGTKVVSHPITGEIQLQINYD-LGN-LIIHILQARNLVPRDNNGYS 4728
Query: 780 NPYVKIYFLPDR---------SDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLE 830
+P+VK+Y LP R S + KRRTK V+K+L P+WNQT IY + + +++ LE
Sbjct: 4729 DPFVKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLE 4788
Query: 831 ITLWDQARVREEESEFLGEILIEL-ETALLDDEPHWYKL--QTHDV-------SSLPLPH 880
+T+WD R ++FLGE+LI+L T+ LD+ P WY L QT + S
Sbjct: 4789 VTVWDYDRF--SSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQSSQQS 4846
Query: 881 PSPYMPRRQLHGESP 895
P P + + + HG P
Sbjct: 4847 PKPSVIKSRSHGIFP 4861
Score = 82.0 bits (201), Expect = 3e-15
Identities = 95/336 (28%), Positives = 146/336 (43%), Gaps = 54/336 (16%)
Query: 1018 EAADRQPYHRSRSTEQRPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAP-PSPALSRS 1076
E+ D H S+S++Q P +RS PD + +P++ S+P S + S
Sbjct: 4830 ESIDHGKSHSSQSSQQSPKPSVIKSRSHGIF-PDPSKDMQVPTIEKSHSSPGSSKSSSEG 4888
Query: 1077 HPRTGSVQTSPSSTPV--------------AGRRGRQLPQLPPKGTLDRKAGGKKLRSTV 1122
H R+ S S T V A +QL P K R A +
Sbjct: 4889 HLRSHGPSRSQSKTSVTQTHLEDAGAAIAAAEAAVQQLRIQPTKPPNHRPAESSVSTGSS 4948
Query: 1123 QRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGP 1182
S +G +V+ ++GS +S + E NL FP R+ Q +G P
Sbjct: 4949 GSSFGSGYSVD-------------SEGS-SSTAGETNL-FPIPRIGKMGQ-----NGQEP 4988
Query: 1183 AQLVG------RQTLATPAMGDIQVGM---MDKKG-QLEVEIIRARGLVVKPGSKT-LPA 1231
+ G T MG+I++ + M G QL VEI++ R + K S LP
Sbjct: 4989 VKQPGVGVGLADTEAKTQVMGEIKIALKKEMKTDGEQLIVEILQCRNITYKFKSPDHLPD 5048
Query: 1232 PYVKVYLLDNGVC--IAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMDH 1289
YVK+Y+++ + KKKT+V R EP + + F SP G LQI+++ + G+
Sbjct: 5049 LYVKIYVMNISTQKKVIKKKTRVCRHDREPSFNETFRFSLSPAGHSLQILLFSNGGKFMK 5108
Query: 1290 KSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPT 1325
K+ +G A I LD+++L ++ W KL LV PT
Sbjct: 5109 KTLIGEACIWLDKVDLRKRIVNWHKL-----LVSPT 5139
Score = 57.0 bits (136), Expect = 1e-07
Identities = 50/176 (28%), Positives = 82/176 (46%), Gaps = 20/176 (11%)
Query: 1187 GRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLL------- 1239
G + ++ P G+IQ+ + G L + I++AR LV + + P+VKVYLL
Sbjct: 4686 GTKVVSHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNG-YSDPFVKVYLLPGRGQVM 4744
Query: 1240 --DNGVCIAKKKTKVARKTLEPLYQQLLSFE----ESPQGKVLQIIVWGDYGRMDHKSFM 1293
N K++TK +K+L P + Q + ++ E + K L++ VW DY R F+
Sbjct: 4745 VVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVW-DYDRFSSNDFL 4803
Query: 1294 GVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSRS 1349
G I L + W+ L + +D + +SQSS + S PS +S
Sbjct: 4804 GEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKS----HSSQSS-QQSPKPSVIKS 4854
Score = 35.8 bits (81), Expect = 0.29
Identities = 23/76 (30%), Positives = 39/76 (51%), Gaps = 4/76 (5%)
Query: 746 RVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNP--YVKIYFLPDRSDKN--KRRTKT 801
++ +K G QLIV IL +++ + P YVKIY + + K K++T+
Sbjct: 5012 KIALKKEMKTDGEQLIVEILQCRNITYKFKSPDHLPDLYVKIYVMNISTQKKVIKKKTRV 5071
Query: 802 VKKTLEPKWNQTFIYS 817
+ EP +N+TF +S
Sbjct: 5072 CRHDREPSFNETFRFS 5087
Score = 34.3 bits (77), Expect = 0.83
Identities = 42/170 (24%), Positives = 65/170 (38%), Gaps = 35/170 (20%)
Query: 6 GPRGRLAPIPAASQPPLQ----------PEMPDLSHLTEEERKIILAVMDRQKKEEEKEQ 55
GP + PA SQPP P P S ++E K A +K E + EQ
Sbjct: 959 GPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAA----EKLEPKAEQ 1014
Query: 56 SVLKKLHQQFEMYKEQVKKMGEESQQQQEQKGDAP-----------TCGICHKTKFADGC 104
+ K + E K+ +S + QK P TC +C KT+ G
Sbjct: 1015 APTVK---RTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLC-KTELNIGS 1070
Query: 105 G-----HNCSYCQTKFCARCGGRVSLRSNKVM-WVCNLCRKQQEILTKSG 148
+ C+ C+ + C CG + ++ W+C C+ Q+ I + G
Sbjct: 1071 KDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLG 1120
Score = 32.7 bits (73), Expect = 2.4
Identities = 41/204 (20%), Positives = 76/204 (37%), Gaps = 14/204 (6%)
Query: 241 RDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSNRRS 300
+ +R + R +Y + T PRS D Q + + D ++S R ++S
Sbjct: 3408 KQPKKRSSGAKVRGQYDDMGENMTDDPRSFKKIVDSGVQTDDEDATDRSYVSRRRRTKKS 3467
Query: 301 HRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQMRIHAEVS 360
S + DDED + D R RR+ +Y A K +P + I +
Sbjct: 3468 VDTSVQ--TDDEDQDEWDMPTRSRRKARV-GKYGDSMTEAD---KTKPLSKVSSIAVQTV 3521
Query: 361 RARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTREAQG 420
+++S+ + R +R ++ I A + + S+ EA
Sbjct: 3522 --------AEISVQTEPVGTIRTPSIRARVDAKVEIIKHISAPEKTYKGGSLGCQTEADS 3573
Query: 421 PSSYAQRTTNHSPPTPRRSPLPID 444
+ Q + SPP ++ P P++
Sbjct: 3574 DTQSPQYLSATSPPKDKKRPTPLE 3597
Score = 31.6 bits (70), Expect = 5.4
Identities = 49/261 (18%), Positives = 92/261 (35%), Gaps = 41/261 (15%)
Query: 15 PAASQPPLQ--------PEMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLKKLHQQFE 66
P +++PP Q P+ P + ++ + + Q K + Q
Sbjct: 504 PGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGS 563
Query: 67 MYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFA-----DGCGHNCSYCQTKFCARCGG 121
Q + ++Q Q C +C+ T+ + C+ CQT C+ CG
Sbjct: 564 GKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGF 623
Query: 122 RVSLRSNKVM-WVCNLCRKQQEI-------------------LTKSGAWFYNSGSNTPQQ 161
+ +V W+C C+ ++ + +T + A + S PQQ
Sbjct: 624 NPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSA--VSKSSPQPQQ 681
Query: 162 PDQKVLRGLRNE--EAPQEKK-PKLHEQTQFQGPSGDLSVPAVEKSRSHGLTRQHSIKNG 218
K + + +AP+ KK P L +Q G S A + + L++ K
Sbjct: 682 TSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSP---SAKAKQPPEADSLSKPAPPKEP 738
Query: 219 SGVKHHIASDIASDRKRSPSV 239
S + +A D+ + P +
Sbjct: 739 SVPSEQDKAPVADDKPKQPKM 759
Score = 31.6 bits (70), Expect = 5.4
Identities = 20/84 (23%), Positives = 39/84 (46%), Gaps = 12/84 (14%)
Query: 3 APVGPRGRLAPIPAASQPPLQPEMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLKKLH 62
AP GP+ P+P S P + + ++E+++ + E E+ +L+K+
Sbjct: 1128 APSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEV----------KTEAEKVILEKVK 1177
Query: 63 QQFEMYKEQVKKMGEESQQQQEQK 86
+ M E++ M Q+Q+E K
Sbjct: 1178 ETLSM--EKIPPMVTTDQKQEESK 1199
Score = 31.6 bits (70), Expect = 5.4
Identities = 39/183 (21%), Positives = 74/183 (40%), Gaps = 21/183 (11%)
Query: 178 EKKPKLHEQTQFQGPSGDLSVPAVEKSRSHGLTRQHSIKNGSGVKHHIASDIASDRKRSP 237
+KK L+ + + L+ ++SR G + H+ G S + D SP
Sbjct: 1686 QKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSP 1745
Query: 238 SVSRDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSN 297
S + ++++ QR+ R P P S E + E+ + L ++
Sbjct: 1746 SHKKGESKQ--QRKARHR-----------PHGPLLPTIEDSSEEEELREEEELLKEQEKQ 1792
Query: 298 RRSHRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDP-NLARYPVKPQPYEEQMRIH 356
R + ++ + + +DE QRR E R ++ P NL+ P++ E++R
Sbjct: 1793 REIEQQQRK-SSSKKSKKDKDELRAQRRRE----RPKTPPSNLS--PIEDASPTEELRQA 1845
Query: 357 AEV 359
AE+
Sbjct: 1846 AEM 1848
>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
[Homo sapiens]
Length = 1634
Score = 71.2 bits (173), Expect = 6e-12
Identities = 49/145 (33%), Positives = 78/145 (53%), Gaps = 11/145 (7%)
Query: 1179 GLGPAQLVGRQTLATPAM---GDIQVGMMDKKGQLEVEIIRARGL-VVKPGSKTLPAPYV 1234
G PA T A P G++++ + K +L + ++ RGL +++ G+ P PYV
Sbjct: 1485 GTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGND--PDPYV 1542
Query: 1235 KVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQG----KVLQIIVWGDYGRMDHK 1290
K+YLL + K+KTKVARKT P Y ++L ++ P+G + LQ+ V + G ++
Sbjct: 1543 KIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWEN- 1601
Query: 1291 SFMGVAQILLDELELSNMVIGWFKL 1315
+G I L EL+L+ GWF L
Sbjct: 1602 VLLGEVNIRLRELDLAQEKTGWFAL 1626
Score = 69.7 bits (169), Expect = 2e-11
Identities = 37/130 (28%), Positives = 69/130 (53%), Gaps = 3/130 (2%)
Query: 748 QIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLE 807
++KL ++L + ++ + L +DG +PYVKIY LPD KR+TK +KT
Sbjct: 1507 EVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCN 1566
Query: 808 PKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIEL-ETALLDDEPHWY 866
P +N+ +Y + + + ++R L++++ + E+ LGE+ I L E L ++ W+
Sbjct: 1567 PTYNEMLVYDGIPKGDLQQRELQLSVLSEQGF--WENVLLGEVNIRLRELDLAQEKTGWF 1624
Query: 867 KLQTHDVSSL 876
L + +L
Sbjct: 1625 ALGSRSHGTL 1634
>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
[Homo sapiens]
Length = 1686
Score = 70.9 bits (172), Expect = 8e-12
Identities = 42/121 (34%), Positives = 65/121 (53%), Gaps = 4/121 (3%)
Query: 749 IKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEP 808
+KL L + ++ KDL + EDG NPYVK Y LPD +KR+TK +KT P
Sbjct: 1563 VKLSISYRNGTLFIMVMHIKDLVT-EDGADPNPYVKTYLLPDNHKTSKRKTKISRKTRNP 1621
Query: 809 KWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEP-HWYK 867
+N+ +YS + R+R L++++ +R E+ FLG + + L+ L E WY+
Sbjct: 1622 TFNEMLVYSGYSKETLRQRELQLSVLSAESLR--ENFFLGGVTLPLKDFNLSKETVKWYQ 1679
Query: 868 L 868
L
Sbjct: 1680 L 1680
Score = 56.6 bits (135), Expect = 2e-07
Identities = 34/123 (27%), Positives = 66/123 (53%), Gaps = 7/123 (5%)
Query: 1197 GDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKT 1256
G +++ + + G L + ++ + LV + G+ P PYVK YLL + +K+KTK++RKT
Sbjct: 1561 GAVKLSISYRNGTLFIMVMHIKDLVTEDGAD--PNPYVKTYLLPDNHKTSKRKTKISRKT 1618
Query: 1257 LEPLYQQLLSF----EESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGW 1312
P + ++L + +E+ + + LQ+ V + F+G + L + LS + W
Sbjct: 1619 RNPTFNEMLVYSGYSKETLRQRELQLSVLSAES-LRENFFLGGVTLPLKDFNLSKETVKW 1677
Query: 1313 FKL 1315
++L
Sbjct: 1678 YQL 1680
>gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens]
Length = 1104
Score = 70.1 bits (170), Expect = 1e-11
Identities = 49/184 (26%), Positives = 86/184 (46%), Gaps = 5/184 (2%)
Query: 687 STHAQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSSQSLSRRTTPFVPR 746
S H+ +E+ S S+ S P + P+ S + +
Sbjct: 915 SQHSGVEAHSHSYSHSSSSLSEEPELSGGPPHITSSAPELRQRLTHVDSPLEAPAGPLGQ 974
Query: 747 VQIKLWFDKVGHQLIVTILGAKDLPSREDGR-PRNPYVKIYFLPDRSDKNKRRTKTVKKT 805
V++ LW+ +L+ + G + L R++GR P +PYV + LPD++ KRRT K+T
Sbjct: 975 VKLTLWYYSEERKLVSIVHGCRSL--RQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKKRT 1032
Query: 806 LEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIEL-ETALLDDEPH 864
L P++N+ F + + E + R L++++ + E E LG++ ++L ET L
Sbjct: 1033 LSPEFNERFEWE-LPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVAR 1091
Query: 865 WYKL 868
WY L
Sbjct: 1092 WYDL 1095
Score = 36.6 bits (83), Expect = 0.17
Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 4/90 (4%)
Query: 1230 PAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFE---ESPQGKVLQIIVWGDYGR 1286
P PYV + LL + K++T ++TL P + + +E + Q + L + V +
Sbjct: 1006 PDPYVSLLLLPDKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSF 1065
Query: 1287 MD-HKSFMGVAQILLDELELSNMVIGWFKL 1315
M + +G Q+ L E +LS V W+ L
Sbjct: 1066 MSRERELLGKVQLDLAETDLSQGVARWYDL 1095
Score = 33.9 bits (76), Expect = 1.1
Identities = 58/256 (22%), Positives = 105/256 (41%), Gaps = 57/256 (22%)
Query: 758 HQLIVTILGAKDLPSRE-------DGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKW 810
H L + +L A+DL +++ G+ +PYVK+ L RS R+ V++ L P+W
Sbjct: 647 HVLRIHVLEAQDLIAKDRFLGGLVKGKS-DPYVKLK-LAGRSF----RSHVVREDLNPRW 700
Query: 811 NQTF--IYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETAL----LDDEPH 864
N+ F I + V +E LE+ ++D+ ++ +FLG + L T L LD+
Sbjct: 701 NEVFEVIVTSVPGQE-----LEVEVFDKDL---DKDDFLGRCKVRLTTVLNSGFLDE--- 749
Query: 865 WYKLQTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQRSKRISDSEVSDYDCDDGIGVVSD 924
W L+ +P ++ +L L+ +++ + + ++S
Sbjct: 750 WLTLE-------DVPSGRLHLRLERLTPRPTAAELEEVLQVNSLIQTQKSAELAAALLSI 802
Query: 925 YRHDGRDLQSSTLSVPEQVMSSNHCSP------SGSPHRVDVIGRTRS--WSPS----VP 972
Y DL + H SP S H+ I +T + W S +
Sbjct: 803 YMERAEDLPLR--------KGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIR 854
Query: 973 PPQSRNVEQGLRGTRT 988
P + ++E +RG T
Sbjct: 855 KPHTESLELQVRGEGT 870
>gi|193804862 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 70.1 bits (170), Expect = 1e-11
Identities = 37/106 (34%), Positives = 63/106 (59%), Gaps = 2/106 (1%)
Query: 757 GHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIY 816
G +L V I AK+L + + G + +VK Y LP R+ +KR+T +KKTL P +N TF+Y
Sbjct: 525 GGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVY 584
Query: 817 SPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDE 862
+ V + + LE+T+WD+ + ++FLG + + + T + + E
Sbjct: 585 NGVRLEDLQHMCLELTVWDREPL--ASNDFLGGVRLGVGTGISNGE 628
Score = 60.1 bits (144), Expect = 1e-08
Identities = 47/204 (23%), Positives = 93/204 (45%), Gaps = 11/204 (5%)
Query: 661 ILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQ---KMDRPSISVTSPMSP 717
+++ +PE V S +GD + + +E + K+ R ++ +S S
Sbjct: 275 VIDLRPEDVVH--ESGSLGDRSKSVPGLNVDMEEEEEEEDIDHLVKLHRQKLARSSMQSG 332
Query: 718 GMLRDVPQFLSGQLSSQSLSRRTTPFVPRVQIKLWFDKVGHQLIVTILGAKDLPSREDGR 777
+ + +S + S++ R+ L +++ L+V + L ++ +
Sbjct: 333 SSMSTIGSMMS--IYSEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAK 390
Query: 778 PR-NPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQ 836
R NPYVK Y LPD+S + KR+T + T+ P +++T Y + +R L+ ++W
Sbjct: 391 KRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYE-IPESLLAQRTLQFSVWHH 449
Query: 837 ARVREEESEFLGEILIELETALLD 860
R + FLGE I++++ LD
Sbjct: 450 GRF--GRNTFLGEAEIQMDSWKLD 471
Score = 57.4 bits (137), Expect = 9e-08
Identities = 64/264 (24%), Positives = 102/264 (38%), Gaps = 62/264 (23%)
Query: 25 EMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLKKLHQQFEMYKEQVKKMGEESQQQQE 84
E+ DLS L+EEE+ +IL+V+ R ++ + ++ +++L + K + K G + +
Sbjct: 3 ELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDR- 61
Query: 85 QKGDAPTCGICH--------KTKFADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNL 136
TC C KT GC H C C ++ + W C +
Sbjct: 62 ------TCARCQESLGRLSPKTNTCRGCNH-------LVCRDC----RIQESNGTWRCKV 104
Query: 137 CRKQQEILTKSGAWFYNSGSNTPQQPDQKVLRGLRNEEAPQEKKPKLHEQTQFQGPSGDL 196
C K+ E+ +G WFY DQKV R + + H+
Sbjct: 105 CAKEIELKKATGDWFY----------DQKVNRFAYRTGSEIIRMSLRHK----------- 143
Query: 197 SVPAVEKSRSHGLTRQHSIKNGS---GVKHHIASDIASDRKRSPSVSRDQNRRYDQREER 253
PAV K + G + H + G G K I +R++ PSV + + +
Sbjct: 144 --PAVSKRETVGQSLLHQTQMGDIWPGRK------IIQERQKEPSVLFEVPKLKSGKSAL 195
Query: 254 EEYSQYATSDTAMPRSPSDYADRR 277
E S+ S TA SD RR
Sbjct: 196 EAESESLDSFTA----DSDSTSRR 215
Score = 55.1 bits (131), Expect = 5e-07
Identities = 39/123 (31%), Positives = 56/123 (45%), Gaps = 6/123 (4%)
Query: 1210 LEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEE 1269
L V + L +K PYVK YLL + K+KT + R T+ PLY + L + E
Sbjct: 373 LVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRY-E 431
Query: 1270 SPQG----KVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPT 1325
P+ + LQ VW +GR +F+G A+I +D +L + L S PT
Sbjct: 432 IPESLLAQRTLQFSVW-HHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPT 490
Query: 1326 LAP 1328
P
Sbjct: 491 GLP 493
Score = 41.6 bits (96), Expect = 0.005
Identities = 35/124 (28%), Positives = 55/124 (44%), Gaps = 6/124 (4%)
Query: 1193 TPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKV 1252
TP GD + + G+L+V I A+ L T + +VK YLL +K+KT V
Sbjct: 511 TPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDS-FVKGYLLPMRNKASKRKTPV 569
Query: 1253 ARKTLEPLYQQLLSFE----ESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNM 1308
+KTL P Y + E Q L++ VW D + F+G ++ + +
Sbjct: 570 MKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVW-DREPLASNDFLGGVRLGVGTGISNGE 628
Query: 1309 VIGW 1312
V+ W
Sbjct: 629 VVDW 632
>gi|193804860 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 70.1 bits (170), Expect = 1e-11
Identities = 37/106 (34%), Positives = 63/106 (59%), Gaps = 2/106 (1%)
Query: 757 GHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIY 816
G +L V I AK+L + + G + +VK Y LP R+ +KR+T +KKTL P +N TF+Y
Sbjct: 525 GGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVY 584
Query: 817 SPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDE 862
+ V + + LE+T+WD+ + ++FLG + + + T + + E
Sbjct: 585 NGVRLEDLQHMCLELTVWDREPL--ASNDFLGGVRLGVGTGISNGE 628
Score = 60.1 bits (144), Expect = 1e-08
Identities = 47/204 (23%), Positives = 93/204 (45%), Gaps = 11/204 (5%)
Query: 661 ILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQ---KMDRPSISVTSPMSP 717
+++ +PE V S +GD + + +E + K+ R ++ +S S
Sbjct: 275 VIDLRPEDVVH--ESGSLGDRSKSVPGLNVDMEEEEEEEDIDHLVKLHRQKLARSSMQSG 332
Query: 718 GMLRDVPQFLSGQLSSQSLSRRTTPFVPRVQIKLWFDKVGHQLIVTILGAKDLPSREDGR 777
+ + +S + S++ R+ L +++ L+V + L ++ +
Sbjct: 333 SSMSTIGSMMS--IYSEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAK 390
Query: 778 PR-NPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQ 836
R NPYVK Y LPD+S + KR+T + T+ P +++T Y + +R L+ ++W
Sbjct: 391 KRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYE-IPESLLAQRTLQFSVWHH 449
Query: 837 ARVREEESEFLGEILIELETALLD 860
R + FLGE I++++ LD
Sbjct: 450 GRF--GRNTFLGEAEIQMDSWKLD 471
Score = 57.4 bits (137), Expect = 9e-08
Identities = 64/264 (24%), Positives = 102/264 (38%), Gaps = 62/264 (23%)
Query: 25 EMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLKKLHQQFEMYKEQVKKMGEESQQQQE 84
E+ DLS L+EEE+ +IL+V+ R ++ + ++ +++L + K + K G + +
Sbjct: 3 ELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDR- 61
Query: 85 QKGDAPTCGICH--------KTKFADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNL 136
TC C KT GC H C C ++ + W C +
Sbjct: 62 ------TCARCQESLGRLSPKTNTCRGCNH-------LVCRDC----RIQESNGTWRCKV 104
Query: 137 CRKQQEILTKSGAWFYNSGSNTPQQPDQKVLRGLRNEEAPQEKKPKLHEQTQFQGPSGDL 196
C K+ E+ +G WFY DQKV R + + H+
Sbjct: 105 CAKEIELKKATGDWFY----------DQKVNRFAYRTGSEIIRMSLRHK----------- 143
Query: 197 SVPAVEKSRSHGLTRQHSIKNGS---GVKHHIASDIASDRKRSPSVSRDQNRRYDQREER 253
PAV K + G + H + G G K I +R++ PSV + + +
Sbjct: 144 --PAVSKRETVGQSLLHQTQMGDIWPGRK------IIQERQKEPSVLFEVPKLKSGKSAL 195
Query: 254 EEYSQYATSDTAMPRSPSDYADRR 277
E S+ S TA SD RR
Sbjct: 196 EAESESLDSFTA----DSDSTSRR 215
Score = 55.1 bits (131), Expect = 5e-07
Identities = 39/123 (31%), Positives = 56/123 (45%), Gaps = 6/123 (4%)
Query: 1210 LEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEE 1269
L V + L +K PYVK YLL + K+KT + R T+ PLY + L + E
Sbjct: 373 LVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRY-E 431
Query: 1270 SPQG----KVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPT 1325
P+ + LQ VW +GR +F+G A+I +D +L + L S PT
Sbjct: 432 IPESLLAQRTLQFSVW-HHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPT 490
Query: 1326 LAP 1328
P
Sbjct: 491 GLP 493
Score = 41.6 bits (96), Expect = 0.005
Identities = 35/124 (28%), Positives = 55/124 (44%), Gaps = 6/124 (4%)
Query: 1193 TPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKV 1252
TP GD + + G+L+V I A+ L T + +VK YLL +K+KT V
Sbjct: 511 TPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDS-FVKGYLLPMRNKASKRKTPV 569
Query: 1253 ARKTLEPLYQQLLSFE----ESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNM 1308
+KTL P Y + E Q L++ VW D + F+G ++ + +
Sbjct: 570 MKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVW-DREPLASNDFLGGVRLGVGTGISNGE 628
Query: 1309 VIGW 1312
V+ W
Sbjct: 629 VVDW 632
>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
Length = 694
Score = 69.3 bits (168), Expect = 2e-11
Identities = 50/195 (25%), Positives = 84/195 (43%), Gaps = 8/195 (4%)
Query: 666 PEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPS-----ISVTSPMSPGML 720
P+ + E+ S P P + T + +M PS S +P P
Sbjct: 311 PDQKPEVAPSDPGTTAPPREERTGGVGGYPAVGAREDRMSHPSGPYSQASAAAPQ-PAAA 369
Query: 721 RDVPQFLSGQLSSQSLSRRTTPFVPRVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRN 780
R P + + S + ++ L +D+ L TI+ AK L + +
Sbjct: 370 RQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLAD 429
Query: 781 PYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVR 840
PYVK++ LP S NK RTKT++ T P WN+T +Y + + + + L I++ D+ +
Sbjct: 430 PYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKF- 488
Query: 841 EEESEFLGEILIELE 855
+EF+GE L+
Sbjct: 489 -GHNEFIGETRFSLK 502
Score = 59.7 bits (143), Expect = 2e-08
Identities = 45/163 (27%), Positives = 71/163 (43%), Gaps = 28/163 (17%)
Query: 32 LTEEERKIILAVMDRQKKEEEKEQSVLKKLHQQFEMYKEQVKKMGEESQQQQEQKGDAPT 91
LT+EE++II V+ R +K EE EQ + +L + E ++ V G
Sbjct: 50 LTDEEKEIINRVIARAEKMEEMEQERIGRLVDRLENMRKNVAGDGVNR------------ 97
Query: 92 CGICHKTKFADGCGHN-CSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEILTKSGAW 150
C +C + G C C+ C +CG + R + V W+C +C +Q+E+ +SGAW
Sbjct: 98 CILCGEQLGMLGSACVVCEDCKKNVCTKCGVETNNRLHSV-WLCKICIEQREVWKRSGAW 156
Query: 151 FYNS------------GSNTPQQPDQKVLRGLRNEEAPQEKKP 181
F+ PQQP + + AP+ K P
Sbjct: 157 FFKGFPKQVLPQPMPIKKTKPQQPVSE--PAAPEQPAPEPKHP 197
Score = 53.9 bits (128), Expect = 1e-06
Identities = 32/122 (26%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 746 RVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKT 805
++ + L + LIV I+ L + + +P+VK++ PD K K +T+ KKT
Sbjct: 553 KILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKT 612
Query: 806 LEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHW 865
L P++N+ F Y H + ++ L+I++WD + ++++G + + +A + HW
Sbjct: 613 LNPEFNEEFFYDIKH-SDLAKKSLDISVWDYD--IGKSNDYIGGCQLGI-SAKGERLKHW 668
Query: 866 YK 867
Y+
Sbjct: 669 YE 670
Score = 46.2 bits (108), Expect = 2e-04
Identities = 35/100 (35%), Positives = 52/100 (52%), Gaps = 8/100 (8%)
Query: 1210 LEVEIIRARGLVVKP-GSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSF- 1267
L+ II+A+GL KP S L PYVK++LL K +TK R T P++ + L +
Sbjct: 409 LQCTIIKAKGL--KPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYH 466
Query: 1268 ---EESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELE 1304
+E Q K L+I V D + H F+G + L +L+
Sbjct: 467 GITDEDMQRKTLRISVC-DEDKFGHNEFIGETRFSLKKLK 505
Score = 33.1 bits (74), Expect = 1.9
Identities = 32/107 (29%), Positives = 50/107 (46%), Gaps = 7/107 (6%)
Query: 1197 GDIQVGMM--DKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVAR 1254
G I V +M ++G L V IIR L + P+VK++L + AK KT++ +
Sbjct: 552 GKILVSLMYSTQQGGLIVGIIRCVHLAAMDANG-YSDPFVKLWLKPDMGKKAKHKTQIKK 610
Query: 1255 KTLEPLYQQLLSFE---ESPQGKVLQIIVWGDYGRMDHKSFMGVAQI 1298
KTL P + + ++ K L I VW DY ++G Q+
Sbjct: 611 KTLNPEFNEEFFYDIKHSDLAKKSLDISVW-DYDIGKSNDYIGGCQL 656
>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
Length = 690
Score = 69.3 bits (168), Expect = 2e-11
Identities = 50/195 (25%), Positives = 84/195 (43%), Gaps = 8/195 (4%)
Query: 666 PEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPS-----ISVTSPMSPGML 720
P+ + E+ S P P + T + +M PS S +P P
Sbjct: 307 PDQKPEVAPSDPGTTAPPREERTGGVGGYPAVGAREDRMSHPSGPYSQASAAAPQ-PAAA 365
Query: 721 RDVPQFLSGQLSSQSLSRRTTPFVPRVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRN 780
R P + + S + ++ L +D+ L TI+ AK L + +
Sbjct: 366 RQPPPPEEEEEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLAD 425
Query: 781 PYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVR 840
PYVK++ LP S NK RTKT++ T P WN+T +Y + + + + L I++ D+ +
Sbjct: 426 PYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKF- 484
Query: 841 EEESEFLGEILIELE 855
+EF+GE L+
Sbjct: 485 -GHNEFIGETRFSLK 498
Score = 59.7 bits (143), Expect = 2e-08
Identities = 45/163 (27%), Positives = 71/163 (43%), Gaps = 28/163 (17%)
Query: 32 LTEEERKIILAVMDRQKKEEEKEQSVLKKLHQQFEMYKEQVKKMGEESQQQQEQKGDAPT 91
LT+EE++II V+ R +K EE EQ + +L + E ++ V G
Sbjct: 46 LTDEEKEIINRVIARAEKMEEMEQERIGRLVDRLENMRKNVAGDGVNR------------ 93
Query: 92 CGICHKTKFADGCGHN-CSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEILTKSGAW 150
C +C + G C C+ C +CG + R + V W+C +C +Q+E+ +SGAW
Sbjct: 94 CILCGEQLGMLGSACVVCEDCKKNVCTKCGVETNNRLHSV-WLCKICIEQREVWKRSGAW 152
Query: 151 FYNS------------GSNTPQQPDQKVLRGLRNEEAPQEKKP 181
F+ PQQP + + AP+ K P
Sbjct: 153 FFKGFPKQVLPQPMPIKKTKPQQPVSE--PAAPEQPAPEPKHP 193
Score = 53.9 bits (128), Expect = 1e-06
Identities = 32/122 (26%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 746 RVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKT 805
++ + L + LIV I+ L + + +P+VK++ PD K K +T+ KKT
Sbjct: 549 KILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKT 608
Query: 806 LEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHW 865
L P++N+ F Y H + ++ L+I++WD + ++++G + + +A + HW
Sbjct: 609 LNPEFNEEFFYDIKH-SDLAKKSLDISVWDYD--IGKSNDYIGGCQLGI-SAKGERLKHW 664
Query: 866 YK 867
Y+
Sbjct: 665 YE 666
Score = 46.2 bits (108), Expect = 2e-04
Identities = 35/100 (35%), Positives = 52/100 (52%), Gaps = 8/100 (8%)
Query: 1210 LEVEIIRARGLVVKP-GSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSF- 1267
L+ II+A+GL KP S L PYVK++LL K +TK R T P++ + L +
Sbjct: 405 LQCTIIKAKGL--KPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYH 462
Query: 1268 ---EESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELE 1304
+E Q K L+I V D + H F+G + L +L+
Sbjct: 463 GITDEDMQRKTLRISVC-DEDKFGHNEFIGETRFSLKKLK 501
Score = 33.1 bits (74), Expect = 1.9
Identities = 32/107 (29%), Positives = 50/107 (46%), Gaps = 7/107 (6%)
Query: 1197 GDIQVGMM--DKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVAR 1254
G I V +M ++G L V IIR L + P+VK++L + AK KT++ +
Sbjct: 548 GKILVSLMYSTQQGGLIVGIIRCVHLAAMDANG-YSDPFVKLWLKPDMGKKAKHKTQIKK 606
Query: 1255 KTLEPLYQQLLSFE---ESPQGKVLQIIVWGDYGRMDHKSFMGVAQI 1298
KTL P + + ++ K L I VW DY ++G Q+
Sbjct: 607 KTLNPEFNEEFFYDIKHSDLAKKSLDISVW-DYDIGKSNDYIGGCQL 652
>gi|6005997 double C2-like domains, beta [Homo sapiens]
Length = 412
Score = 69.3 bits (168), Expect = 2e-11
Identities = 37/109 (33%), Positives = 59/109 (54%), Gaps = 2/109 (1%)
Query: 747 VQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTL 806
+ L +D+ + L TI AK L + +PYVK++ LP S NK RTKT++ TL
Sbjct: 130 LDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTL 189
Query: 807 EPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELE 855
P WN+T Y + + + L I++ D+ + R +EF+GE + L+
Sbjct: 190 NPTWNETLTYYGITDEDMIRKTLRISVCDEDKFR--HNEFIGETRVPLK 236
Score = 60.5 bits (145), Expect = 1e-08
Identities = 36/121 (29%), Positives = 63/121 (52%), Gaps = 4/121 (3%)
Query: 746 RVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKT 805
R+ I L + L+V I+ L + + +PYVK Y PD K+K +T KKT
Sbjct: 269 RILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKT 328
Query: 806 LEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHW 865
L P++N+ F Y H + ++ LE+T+WD + ++F+G +++ + A + HW
Sbjct: 329 LNPEFNEEFCYEIKH-GDLAKKSLEVTVWDYD--IGKSNDFIGGVVLGIH-AKGERLKHW 384
Query: 866 Y 866
+
Sbjct: 385 F 385
Score = 42.7 bits (99), Expect = 0.002
Identities = 35/117 (29%), Positives = 57/117 (48%), Gaps = 10/117 (8%)
Query: 1195 AMGDIQVGMM--DKKGQLEVEIIRARGLVVKPGSKT-LPAPYVKVYLLDNGVCIAKKKTK 1251
A+G + ++ + L I +A+GL KP L PYVK++LL K +TK
Sbjct: 126 ALGTLDFSLLYDQENNALHCTITKAKGL--KPMDHNGLADPYVKLHLLPGASKANKLRTK 183
Query: 1252 VARKTLEPLYQQLLSF----EESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELE 1304
R TL P + + L++ +E K L+I V D + H F+G ++ L +L+
Sbjct: 184 TLRNTLNPTWNETLTYYGITDEDMIRKTLRISVC-DEDKFRHNEFIGETRVPLKKLK 239
Score = 33.5 bits (75), Expect = 1.4
Identities = 23/66 (34%), Positives = 32/66 (48%), Gaps = 4/66 (6%)
Query: 1232 PYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFE---ESPQGKVLQIIVWGDYGRMD 1288
PYVK YL + +K KT V +KTL P + + +E K L++ VW DY
Sbjct: 304 PYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVW-DYDIGK 362
Query: 1289 HKSFMG 1294
F+G
Sbjct: 363 SNDFIG 368
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 68.9 bits (167), Expect = 3e-11
Identities = 38/137 (27%), Positives = 74/137 (54%), Gaps = 7/137 (5%)
Query: 746 RVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKT 805
R +I L + +L VT+ AK+L + +PYVK+ +PD +++K++TKT++ T
Sbjct: 159 RGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRST 218
Query: 806 LEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHW 865
L P+WN++F + + ++R L + +WD R ++F+G + + + W
Sbjct: 219 LNPQWNESFTFK--LKPSDKDRRLSVEIWDWDRT--TRNDFMGSLSFGVSELMKMPASGW 274
Query: 866 YKL---QTHDVSSLPLP 879
YKL + + ++P+P
Sbjct: 275 YKLLNQEEGEYYNVPIP 291
Score = 47.4 bits (111), Expect = 9e-05
Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 7/110 (6%)
Query: 1209 QLEVEIIRARGLV-VKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSF 1267
+L V + A+ L+ + P L PYVK+ L+ + +K+KTK R TL P + + +F
Sbjct: 172 KLHVTVRDAKNLIPMDPNG--LSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTF 229
Query: 1268 EESPQGK--VLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKL 1315
+ P K L + +W D+ R FMG + EL + GW+KL
Sbjct: 230 KLKPSDKDRRLSVEIW-DWDRTTRNDFMGSLSFGVSEL-MKMPASGWYKL 277
>gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens]
Length = 910
Score = 68.9 bits (167), Expect = 3e-11
Identities = 47/161 (29%), Positives = 84/161 (52%), Gaps = 13/161 (8%)
Query: 719 MLRDVPQFLSGQLSSQSLSRRTTPF-----VPRVQIKLWFDKVGHQLIVTILGAKDLPSR 773
M + VP FL ++S +S + F +Q + + + +L V + KDL +
Sbjct: 575 MSKSVPAFLQDEVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAA 634
Query: 774 EDGRPRN-PYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEIT 832
+ + R+ PYVK Y LPD+ K++T VKKTL P +N+ Y + ++ + + L ++
Sbjct: 635 DVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYK-IEKQILKTQKLNLS 693
Query: 833 LWDQARVREEESEFLGEILIELETALLDDEPH----WYKLQ 869
+W R + + FLGE+ ++LET D++ + WY L+
Sbjct: 694 IWH--RDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLK 732
Score = 53.5 bits (127), Expect = 1e-06
Identities = 30/88 (34%), Positives = 47/88 (53%), Gaps = 4/88 (4%)
Query: 769 DLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERM 828
DLP G N +VK LPD S K++++T+ V KT P +N T +Y + E
Sbjct: 779 DLPLLR-GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEAC 837
Query: 829 LEITLWDQARVREEESEFLGEILIELET 856
+E+T+WD ++ ++FLG + I T
Sbjct: 838 VELTVWDHYKL---TNQFLGGLRIGFGT 862
Score = 52.0 bits (123), Expect = 4e-06
Identities = 75/302 (24%), Positives = 120/302 (39%), Gaps = 38/302 (12%)
Query: 1038 ERTTTRSRSTER-PDTNLMRSMPSLMTGRSA--PPSPALSRSHPRTGSVQTSPSSTPVAG 1094
E T R +S E P N + S +T + P SPA SH V+ PS P
Sbjct: 425 EVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSH----CVEPEPSQVPGGS 480
Query: 1095 RRGRQLPQ----LPPKGTLDRKAGGKKLRSTVQR-STETGLAVEMRNWMTRQASRESTDG 1149
R RQ P TL+R A K +++ S+++ ++ N + R + D
Sbjct: 481 SRDRQQGSEEEPSPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDN-QPEELVRSAEDD 539
Query: 1150 SMNSYSSEGNLIFPGVRLAS---DSQFS--DFLDGLG---PAQLVGRQTLATPAMGDIQV 1201
N P + D+ FS D L + PA L + + ++
Sbjct: 540 EKPDQKPVTNECVPRISTVPTQPDNPFSHPDKLKRMSKSVPAFLQDEVSGSVMSVYSGDF 599
Query: 1202 GMMDKKG-------------QLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKK 1248
G ++ KG +L V + + + L K PYVK YLL + + KK
Sbjct: 600 GNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKK 659
Query: 1249 KTKVARKTLEPLYQQLLSFEESPQ---GKVLQIIVWGDYGRMDHKSFMGVAQILLDELEL 1305
KT V +KTL P+Y ++L ++ Q + L + +W SF+G ++ L+ +
Sbjct: 660 KTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIW-HRDTFKRNSFLGEVELDLETWDW 718
Query: 1306 SN 1307
N
Sbjct: 719 DN 720
>gi|244790016 synaptotagmin-like 2 isoform h [Homo sapiens]
Length = 336
Score = 68.9 bits (167), Expect = 3e-11
Identities = 47/161 (29%), Positives = 84/161 (52%), Gaps = 13/161 (8%)
Query: 719 MLRDVPQFLSGQLSSQSLSRRTTPF-----VPRVQIKLWFDKVGHQLIVTILGAKDLPSR 773
M + VP FL ++S +S + F +Q + + + +L V + KDL +
Sbjct: 1 MSKSVPAFLQDEVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAA 60
Query: 774 EDGRPRN-PYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEIT 832
+ + R+ PYVK Y LPD+ K++T VKKTL P +N+ Y + ++ + + L ++
Sbjct: 61 DVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYK-IEKQILKTQKLNLS 119
Query: 833 LWDQARVREEESEFLGEILIELETALLDDEPH----WYKLQ 869
+W R + + FLGE+ ++LET D++ + WY L+
Sbjct: 120 IWH--RDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLK 158
Score = 53.5 bits (127), Expect = 1e-06
Identities = 30/88 (34%), Positives = 47/88 (53%), Gaps = 4/88 (4%)
Query: 769 DLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERM 828
DLP G N +VK LPD S K++++T+ V KT P +N T +Y + E
Sbjct: 205 DLPLLR-GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEAC 263
Query: 829 LEITLWDQARVREEESEFLGEILIELET 856
+E+T+WD ++ ++FLG + I T
Sbjct: 264 VELTVWDHYKL---TNQFLGGLRIGFGT 288
Score = 48.9 bits (115), Expect = 3e-05
Identities = 33/116 (28%), Positives = 57/116 (49%), Gaps = 6/116 (5%)
Query: 1197 GDIQVGM--MDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVAR 1254
G+IQ + ++ +L V + + + L K PYVK YLL + + KKKT V +
Sbjct: 32 GNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVK 91
Query: 1255 KTLEPLYQQLLSFEESPQ---GKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSN 1307
KTL P+Y ++L ++ Q + L + +W SF+G ++ L+ + N
Sbjct: 92 KTLNPVYNEILRYKIEKQILKTQKLNLSIW-HRDTFKRNSFLGEVELDLETWDWDN 146
>gi|5902064 rabphilin 3A-like (without C2 domains) [Homo sapiens]
Length = 315
Score = 67.8 bits (164), Expect = 7e-11
Identities = 46/165 (27%), Positives = 75/165 (45%), Gaps = 21/165 (12%)
Query: 31 HLTEEERKIILAVMDRQKKEEEKEQSVLKKLHQQFEMYKEQVKKMGEESQQQQEQKGDAP 90
HL+ E + IL V+ R ++ + EQ + +L ++ E + V MG Q
Sbjct: 46 HLSPAEVEAILQVIQRAERLDVLEQQRIGRLVERLETMRRNV--MGNGLSQ--------- 94
Query: 91 TCGICHKTK-FADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEILTKSGA 149
C +C + F C C+ K C +CG S + +W+C +C +Q+E+ +SGA
Sbjct: 95 -CLLCGEVLGFLGSSSVFCKDCRKKVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGA 153
Query: 150 WFYNS------GSNTPQQPDQKVLRGLRNEEAPQEKKPKLHEQTQ 188
WFY TP + D R L E P E++P+ E ++
Sbjct: 154 WFYKGLPKYILPLKTPGRADDPHFRPLPTE--PAEREPRSSETSR 196
>gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 67.4 bits (163), Expect = 9e-11
Identities = 31/80 (38%), Positives = 50/80 (62%)
Query: 757 GHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIY 816
G L V I AK+L + + G + +VK Y LPD S K +T +KK++ P+WN TF++
Sbjct: 586 GGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMF 645
Query: 817 SPVHRREFRERMLEITLWDQ 836
S +H ++ + LE+T+WD+
Sbjct: 646 SGIHPQDIKNVCLELTIWDK 665
Score = 52.0 bits (123), Expect = 4e-06
Identities = 45/187 (24%), Positives = 79/187 (42%), Gaps = 18/187 (9%)
Query: 25 EMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLKKLHQQFEMYKEQVKKMGEESQQQQE 84
E +LS L + E+++IL V+ R + ++ E ++KL + K + K +E+ +
Sbjct: 6 EFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEASR--- 62
Query: 85 QKGDAPTCGICHKTK-FADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEI 143
C CH+ G C C + C C RV+ + W C +C K ++
Sbjct: 63 ------VCVHCHRNLGLIFDRGDPCQACSLRVCREC--RVAGPNGS--WKCTVCDKIAQL 112
Query: 144 LTKSGAWFYNSGSNTPQQPD---QKVLRGLRNEEAPQEKKPKLHEQTQFQGPSGDLSVPA 200
+G WF+ + +Q + V+R +P ++ + EQT+ D S P
Sbjct: 113 RIITGEWFFEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTS-PV 171
Query: 201 VEKSRSH 207
K SH
Sbjct: 172 AGKKASH 178
Score = 51.6 bits (122), Expect = 5e-06
Identities = 33/112 (29%), Positives = 61/112 (54%), Gaps = 6/112 (5%)
Query: 760 LIVTILGAKDLPSREDGRPR-NPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSP 818
L + + ++L ++ + R + YVK Y LPD+S NKR+TK ++ P++N+T Y+
Sbjct: 423 LYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTK-IRTGTNPEFNETLKYTI 481
Query: 819 VHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDD-EPHWYKLQ 869
H + R L++++W R + FLGE+ I ++ ++ W+ LQ
Sbjct: 482 SH-TQLETRTLQLSVWHYDRF--GRNSFLGEVEIPFDSWNFENPTDEWFVLQ 530
Score = 48.1 bits (113), Expect = 6e-05
Identities = 36/115 (31%), Positives = 50/115 (43%), Gaps = 5/115 (4%)
Query: 1206 KKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLL 1265
K G L + + R L + K YVK YLL + K+KTK+ R P + + L
Sbjct: 419 KTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKI-RTGTNPEFNETL 477
Query: 1266 SFEESP---QGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFP 1317
+ S + + LQ+ VW Y R SF+G +I D N WF L P
Sbjct: 478 KYTISHTQLETRTLQLSVW-HYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQP 531
Score = 32.0 bits (71), Expect = 4.1
Identities = 29/106 (27%), Positives = 45/106 (42%), Gaps = 8/106 (7%)
Query: 1180 LGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLL 1239
L P QL G +T G + + G LEV I A+ L T + +VK YLL
Sbjct: 562 LPPEQLQGNKTFKK---GKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDS-FVKGYLL 617
Query: 1240 DNGVCIAKKKTKVARKTLEPLYQQLLSFE----ESPQGKVLQIIVW 1281
+ K KT V +K++ P + F + + L++ +W
Sbjct: 618 PDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIW 663
>gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens]
Length = 752
Score = 67.4 bits (163), Expect = 9e-11
Identities = 31/80 (38%), Positives = 50/80 (62%)
Query: 757 GHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIY 816
G L V I AK+L + + G + +VK Y LPD S K +T +KK++ P+WN TF++
Sbjct: 608 GGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMF 667
Query: 817 SPVHRREFRERMLEITLWDQ 836
S +H ++ + LE+T+WD+
Sbjct: 668 SGIHPQDIKNVCLELTIWDK 687
Score = 52.0 bits (123), Expect = 4e-06
Identities = 45/187 (24%), Positives = 79/187 (42%), Gaps = 18/187 (9%)
Query: 25 EMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLKKLHQQFEMYKEQVKKMGEESQQQQE 84
E +LS L + E+++IL V+ R + ++ E ++KL + K + K +E+ +
Sbjct: 6 EFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEASR--- 62
Query: 85 QKGDAPTCGICHKTK-FADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEI 143
C CH+ G C C + C C RV+ + W C +C K ++
Sbjct: 63 ------VCVHCHRNLGLIFDRGDPCQACSLRVCREC--RVAGPNGS--WKCTVCDKIAQL 112
Query: 144 LTKSGAWFYNSGSNTPQQPD---QKVLRGLRNEEAPQEKKPKLHEQTQFQGPSGDLSVPA 200
+G WF+ + +Q + V+R +P ++ + EQT+ D S P
Sbjct: 113 RIITGEWFFEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTS-PV 171
Query: 201 VEKSRSH 207
K SH
Sbjct: 172 AGKKASH 178
Score = 51.6 bits (122), Expect = 5e-06
Identities = 33/112 (29%), Positives = 61/112 (54%), Gaps = 6/112 (5%)
Query: 760 LIVTILGAKDLPSREDGRPR-NPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSP 818
L + + ++L ++ + R + YVK Y LPD+S NKR+TK ++ P++N+T Y+
Sbjct: 445 LYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTK-IRTGTNPEFNETLKYTI 503
Query: 819 VHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDD-EPHWYKLQ 869
H + R L++++W R + FLGE+ I ++ ++ W+ LQ
Sbjct: 504 SH-TQLETRTLQLSVWHYDRF--GRNSFLGEVEIPFDSWNFENPTDEWFVLQ 552
Score = 48.1 bits (113), Expect = 6e-05
Identities = 36/115 (31%), Positives = 50/115 (43%), Gaps = 5/115 (4%)
Query: 1206 KKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLL 1265
K G L + + R L + K YVK YLL + K+KTK+ R P + + L
Sbjct: 441 KTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKI-RTGTNPEFNETL 499
Query: 1266 SFEESP---QGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFP 1317
+ S + + LQ+ VW Y R SF+G +I D N WF L P
Sbjct: 500 KYTISHTQLETRTLQLSVW-HYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQP 553
Score = 32.0 bits (71), Expect = 4.1
Identities = 29/106 (27%), Positives = 45/106 (42%), Gaps = 8/106 (7%)
Query: 1180 LGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLL 1239
L P QL G +T G + + G LEV I A+ L T + +VK YLL
Sbjct: 584 LPPEQLQGNKTFKK---GKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDS-FVKGYLL 639
Query: 1240 DNGVCIAKKKTKVARKTLEPLYQQLLSFE----ESPQGKVLQIIVW 1281
+ K KT V +K++ P + F + + L++ +W
Sbjct: 640 PDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIW 685
>gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 67.4 bits (163), Expect = 9e-11
Identities = 31/80 (38%), Positives = 50/80 (62%)
Query: 757 GHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIY 816
G L V I AK+L + + G + +VK Y LPD S K +T +KK++ P+WN TF++
Sbjct: 586 GGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMF 645
Query: 817 SPVHRREFRERMLEITLWDQ 836
S +H ++ + LE+T+WD+
Sbjct: 646 SGIHPQDIKNVCLELTIWDK 665
Score = 52.0 bits (123), Expect = 4e-06
Identities = 45/187 (24%), Positives = 79/187 (42%), Gaps = 18/187 (9%)
Query: 25 EMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLKKLHQQFEMYKEQVKKMGEESQQQQE 84
E +LS L + E+++IL V+ R + ++ E ++KL + K + K +E+ +
Sbjct: 6 EFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEASR--- 62
Query: 85 QKGDAPTCGICHKTK-FADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEI 143
C CH+ G C C + C C RV+ + W C +C K ++
Sbjct: 63 ------VCVHCHRNLGLIFDRGDPCQACSLRVCREC--RVAGPNGS--WKCTVCDKIAQL 112
Query: 144 LTKSGAWFYNSGSNTPQQPD---QKVLRGLRNEEAPQEKKPKLHEQTQFQGPSGDLSVPA 200
+G WF+ + +Q + V+R +P ++ + EQT+ D S P
Sbjct: 113 RIITGEWFFEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTS-PV 171
Query: 201 VEKSRSH 207
K SH
Sbjct: 172 AGKKASH 178
Score = 51.6 bits (122), Expect = 5e-06
Identities = 33/112 (29%), Positives = 61/112 (54%), Gaps = 6/112 (5%)
Query: 760 LIVTILGAKDLPSREDGRPR-NPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSP 818
L + + ++L ++ + R + YVK Y LPD+S NKR+TK ++ P++N+T Y+
Sbjct: 423 LYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTK-IRTGTNPEFNETLKYTI 481
Query: 819 VHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDD-EPHWYKLQ 869
H + R L++++W R + FLGE+ I ++ ++ W+ LQ
Sbjct: 482 SH-TQLETRTLQLSVWHYDRF--GRNSFLGEVEIPFDSWNFENPTDEWFVLQ 530
Score = 48.1 bits (113), Expect = 6e-05
Identities = 36/115 (31%), Positives = 50/115 (43%), Gaps = 5/115 (4%)
Query: 1206 KKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLL 1265
K G L + + R L + K YVK YLL + K+KTK+ R P + + L
Sbjct: 419 KTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKI-RTGTNPEFNETL 477
Query: 1266 SFEESP---QGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFP 1317
+ S + + LQ+ VW Y R SF+G +I D N WF L P
Sbjct: 478 KYTISHTQLETRTLQLSVW-HYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQP 531
Score = 32.0 bits (71), Expect = 4.1
Identities = 29/106 (27%), Positives = 45/106 (42%), Gaps = 8/106 (7%)
Query: 1180 LGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLL 1239
L P QL G +T G + + G LEV I A+ L T + +VK YLL
Sbjct: 562 LPPEQLQGNKTFKK---GKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDS-FVKGYLL 617
Query: 1240 DNGVCIAKKKTKVARKTLEPLYQQLLSFE----ESPQGKVLQIIVW 1281
+ K KT V +K++ P + F + + L++ +W
Sbjct: 618 PDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIW 663
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 67.4 bits (163), Expect = 9e-11
Identities = 44/123 (35%), Positives = 68/123 (55%), Gaps = 8/123 (6%)
Query: 746 RVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKT 805
R+ L + QL+V IL A DLP+++ +PYVKIY LPDR K K +TK +KT
Sbjct: 302 RISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDR--KKKFQTKVHRKT 359
Query: 806 LEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLD---DE 862
L P +N+TF +S V E +R L +++D R + +G+++++ L + D
Sbjct: 360 LNPVFNETFQFS-VPLAELAQRKLHFSVYDFDRF--SRHDLIGQVVLDNLLELAEQPPDR 416
Query: 863 PHW 865
P W
Sbjct: 417 PLW 419
Score = 48.5 bits (114), Expect = 4e-05
Identities = 88/310 (28%), Positives = 115/310 (37%), Gaps = 63/310 (20%)
Query: 1024 PYHRSRSTEQRP---LLERTTTRSRSTERPDTNLMRSMPSLMTGR-SAPPSPALSRSHPR 1079
P+H + + P LLE + T P M S P +A P+
Sbjct: 130 PHHHAHAAHHPPFAELLEPGSLGGSDTPEPSYLDMDSYPEAAAAAVAAGVKPS------- 182
Query: 1080 TGSVQTSPSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMR---- 1135
QTSP P G G L LPP G GG L S T LA R
Sbjct: 183 ----QTSPE-LPSEGGAGSGLLLLPPSG------GG--LPSAQSHQQVTSLAPTTRYPAL 229
Query: 1136 -NWMTRQASRESTDGSMNSYSSEGNLIFPG----VRLASDSQFSDFLDGLGPAQLVGRQT 1190
+T+Q D S L PG +L + + G GP GR++
Sbjct: 230 PRPLTQQTLTSQPDPSSEERPPALPLPLPGGEEKAKLIGQIK-PELYQGTGPG---GRRS 285
Query: 1191 LATPAMGDIQVGM-----------MDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLL 1239
P G+ G + QL V I++A L K S PYVK+YLL
Sbjct: 286 GGGPGSGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKD-SNGFSDPYVKIYLL 344
Query: 1240 DNGVCIAKKK--TKVARKTLEPLYQQLLSFE----ESPQGKVLQIIVWGDYGRMDHKSFM 1293
+ KKK TKV RKTL P++ + F E Q K L V+ D+ R +
Sbjct: 345 PD----RKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRK-LHFSVY-DFDRFSRHDLI 398
Query: 1294 GVAQILLDEL 1303
G Q++LD L
Sbjct: 399 G--QVVLDNL 406
Score = 46.2 bits (108), Expect = 2e-04
Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 3/93 (3%)
Query: 1208 GQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSF 1267
G+L V II+A L + PYVK L+ G + K+KT + + TL P Y + L F
Sbjct: 446 GRLTVTIIKASNLKAMDLTG-FSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVF 504
Query: 1268 EESPQG--KVLQIIVWGDYGRMDHKSFMGVAQI 1298
+ +P+ V I DY + H +GV ++
Sbjct: 505 DVAPESVENVGLSIAVVDYDCIGHNEVIGVCRV 537
Score = 35.8 bits (81), Expect = 0.29
Identities = 18/58 (31%), Positives = 31/58 (53%)
Query: 759 QLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIY 816
+L VTI+ A +L + + +PYVK + + KR+T K TL P +N+ ++
Sbjct: 447 RLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVF 504
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 67.4 bits (163), Expect = 9e-11
Identities = 44/123 (35%), Positives = 68/123 (55%), Gaps = 8/123 (6%)
Query: 746 RVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKT 805
R+ L + QL+V IL A DLP+++ +PYVKIY LPDR K K +TK +KT
Sbjct: 302 RISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDR--KKKFQTKVHRKT 359
Query: 806 LEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLD---DE 862
L P +N+TF +S V E +R L +++D R + +G+++++ L + D
Sbjct: 360 LNPVFNETFQFS-VPLAELAQRKLHFSVYDFDRF--SRHDLIGQVVLDNLLELAEQPPDR 416
Query: 863 PHW 865
P W
Sbjct: 417 PLW 419
Score = 48.5 bits (114), Expect = 4e-05
Identities = 88/310 (28%), Positives = 115/310 (37%), Gaps = 63/310 (20%)
Query: 1024 PYHRSRSTEQRP---LLERTTTRSRSTERPDTNLMRSMPSLMTGR-SAPPSPALSRSHPR 1079
P+H + + P LLE + T P M S P +A P+
Sbjct: 130 PHHHAHAAHHPPFAELLEPGSLGGSDTPEPSYLDMDSYPEAAAAAVAAGVKPS------- 182
Query: 1080 TGSVQTSPSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMR---- 1135
QTSP P G G L LPP G GG L S T LA R
Sbjct: 183 ----QTSPE-LPSEGGAGSGLLLLPPSG------GG--LPSAQSHQQVTSLAPTTRYPAL 229
Query: 1136 -NWMTRQASRESTDGSMNSYSSEGNLIFPG----VRLASDSQFSDFLDGLGPAQLVGRQT 1190
+T+Q D S L PG +L + + G GP GR++
Sbjct: 230 PRPLTQQTLTSQPDPSSEERPPALPLPLPGGEEKAKLIGQIK-PELYQGTGPG---GRRS 285
Query: 1191 LATPAMGDIQVGM-----------MDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLL 1239
P G+ G + QL V I++A L K S PYVK+YLL
Sbjct: 286 GGGPGSGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKD-SNGFSDPYVKIYLL 344
Query: 1240 DNGVCIAKKK--TKVARKTLEPLYQQLLSFE----ESPQGKVLQIIVWGDYGRMDHKSFM 1293
+ KKK TKV RKTL P++ + F E Q K L V+ D+ R +
Sbjct: 345 PD----RKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRK-LHFSVY-DFDRFSRHDLI 398
Query: 1294 GVAQILLDEL 1303
G Q++LD L
Sbjct: 399 G--QVVLDNL 406
Score = 46.2 bits (108), Expect = 2e-04
Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 3/93 (3%)
Query: 1208 GQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSF 1267
G+L V II+A L + PYVK L+ G + K+KT + + TL P Y + L F
Sbjct: 446 GRLTVTIIKASNLKAMDLTG-FSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVF 504
Query: 1268 EESPQG--KVLQIIVWGDYGRMDHKSFMGVAQI 1298
+ +P+ V I DY + H +GV ++
Sbjct: 505 DVAPESVENVGLSIAVVDYDCIGHNEVIGVCRV 537
Score = 35.8 bits (81), Expect = 0.29
Identities = 18/58 (31%), Positives = 31/58 (53%)
Query: 759 QLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIY 816
+L VTI+ A +L + + +PYVK + + KR+T K TL P +N+ ++
Sbjct: 447 RLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVF 504
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 67.4 bits (163), Expect = 9e-11
Identities = 44/123 (35%), Positives = 68/123 (55%), Gaps = 8/123 (6%)
Query: 746 RVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKT 805
R+ L + QL+V IL A DLP+++ +PYVKIY LPDR K K +TK +KT
Sbjct: 302 RISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDR--KKKFQTKVHRKT 359
Query: 806 LEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLD---DE 862
L P +N+TF +S V E +R L +++D R + +G+++++ L + D
Sbjct: 360 LNPVFNETFQFS-VPLAELAQRKLHFSVYDFDRF--SRHDLIGQVVLDNLLELAEQPPDR 416
Query: 863 PHW 865
P W
Sbjct: 417 PLW 419
Score = 48.5 bits (114), Expect = 4e-05
Identities = 88/310 (28%), Positives = 115/310 (37%), Gaps = 63/310 (20%)
Query: 1024 PYHRSRSTEQRP---LLERTTTRSRSTERPDTNLMRSMPSLMTGR-SAPPSPALSRSHPR 1079
P+H + + P LLE + T P M S P +A P+
Sbjct: 130 PHHHAHAAHHPPFAELLEPGSLGGSDTPEPSYLDMDSYPEAAAAAVAAGVKPS------- 182
Query: 1080 TGSVQTSPSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMR---- 1135
QTSP P G G L LPP G GG L S T LA R
Sbjct: 183 ----QTSPE-LPSEGGAGSGLLLLPPSG------GG--LPSAQSHQQVTSLAPTTRYPAL 229
Query: 1136 -NWMTRQASRESTDGSMNSYSSEGNLIFPG----VRLASDSQFSDFLDGLGPAQLVGRQT 1190
+T+Q D S L PG +L + + G GP GR++
Sbjct: 230 PRPLTQQTLTSQPDPSSEERPPALPLPLPGGEEKAKLIGQIK-PELYQGTGPG---GRRS 285
Query: 1191 LATPAMGDIQVGM-----------MDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLL 1239
P G+ G + QL V I++A L K S PYVK+YLL
Sbjct: 286 GGGPGSGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKD-SNGFSDPYVKIYLL 344
Query: 1240 DNGVCIAKKK--TKVARKTLEPLYQQLLSFE----ESPQGKVLQIIVWGDYGRMDHKSFM 1293
+ KKK TKV RKTL P++ + F E Q K L V+ D+ R +
Sbjct: 345 PD----RKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRK-LHFSVY-DFDRFSRHDLI 398
Query: 1294 GVAQILLDEL 1303
G Q++LD L
Sbjct: 399 G--QVVLDNL 406
Score = 46.2 bits (108), Expect = 2e-04
Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 3/93 (3%)
Query: 1208 GQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSF 1267
G+L V II+A L + PYVK L+ G + K+KT + + TL P Y + L F
Sbjct: 446 GRLTVTIIKASNLKAMDLTG-FSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVF 504
Query: 1268 EESPQG--KVLQIIVWGDYGRMDHKSFMGVAQI 1298
+ +P+ V I DY + H +GV ++
Sbjct: 505 DVAPESVENVGLSIAVVDYDCIGHNEVIGVCRV 537
Score = 35.8 bits (81), Expect = 0.29
Identities = 18/58 (31%), Positives = 31/58 (53%)
Query: 759 QLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIY 816
+L VTI+ A +L + + +PYVK + + KR+T K TL P +N+ ++
Sbjct: 447 RLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVF 504
>gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens]
Length = 376
Score = 66.2 bits (160), Expect = 2e-10
Identities = 47/181 (25%), Positives = 89/181 (49%), Gaps = 8/181 (4%)
Query: 694 SSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSSQSLSRRTTPFVPRVQIKLWF 753
+S SS++ + + S+T+ S + + +S S +Q + +
Sbjct: 21 ASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEY 80
Query: 754 DKVGHQLIVTILGAKDLPSREDGRPRN-PYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQ 812
+ +L V + KDL + + + R+ PYVK Y LPD+ K++T VKKTL P +N+
Sbjct: 81 VESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNE 140
Query: 813 TFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPH----WYKL 868
Y + ++ + + L +++W R + + FLGE+ ++LET D++ + WY L
Sbjct: 141 ILRYK-IEKQILKTQKLNLSIWH--RDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPL 197
Query: 869 Q 869
+
Sbjct: 198 K 198
Score = 53.5 bits (127), Expect = 1e-06
Identities = 30/88 (34%), Positives = 47/88 (53%), Gaps = 4/88 (4%)
Query: 769 DLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERM 828
DLP G N +VK LPD S K++++T+ V KT P +N T +Y + E
Sbjct: 245 DLPLLR-GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEAC 303
Query: 829 LEITLWDQARVREEESEFLGEILIELET 856
+E+T+WD ++ ++FLG + I T
Sbjct: 304 VELTVWDHYKL---TNQFLGGLRIGFGT 328
Score = 48.9 bits (115), Expect = 3e-05
Identities = 33/116 (28%), Positives = 57/116 (49%), Gaps = 6/116 (5%)
Query: 1197 GDIQVGM--MDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVAR 1254
G+IQ + ++ +L V + + + L K PYVK YLL + + KKKT V +
Sbjct: 72 GNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVK 131
Query: 1255 KTLEPLYQQLLSFEESPQ---GKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSN 1307
KTL P+Y ++L ++ Q + L + +W SF+G ++ L+ + N
Sbjct: 132 KTLNPVYNEILRYKIEKQILKTQKLNLSIW-HRDTFKRNSFLGEVELDLETWDWDN 186
>gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens]
Length = 935
Score = 66.2 bits (160), Expect = 2e-10
Identities = 47/181 (25%), Positives = 89/181 (49%), Gaps = 8/181 (4%)
Query: 694 SSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSSQSLSRRTTPFVPRVQIKLWF 753
+S SS++ + + S+T+ S + + +S S +Q + +
Sbjct: 580 ASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEY 639
Query: 754 DKVGHQLIVTILGAKDLPSREDGRPRN-PYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQ 812
+ +L V + KDL + + + R+ PYVK Y LPD+ K++T VKKTL P +N+
Sbjct: 640 VESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNE 699
Query: 813 TFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPH----WYKL 868
Y + ++ + + L +++W R + + FLGE+ ++LET D++ + WY L
Sbjct: 700 ILRYK-IEKQILKTQKLNLSIWH--RDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPL 756
Query: 869 Q 869
+
Sbjct: 757 K 757
Score = 53.5 bits (127), Expect = 1e-06
Identities = 30/88 (34%), Positives = 47/88 (53%), Gaps = 4/88 (4%)
Query: 769 DLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERM 828
DLP G N +VK LPD S K++++T+ V KT P +N T +Y + E
Sbjct: 804 DLPLLR-GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEAC 862
Query: 829 LEITLWDQARVREEESEFLGEILIELET 856
+E+T+WD ++ ++FLG + I T
Sbjct: 863 VELTVWDHYKL---TNQFLGGLRIGFGT 887
Score = 48.9 bits (115), Expect = 3e-05
Identities = 33/116 (28%), Positives = 57/116 (49%), Gaps = 6/116 (5%)
Query: 1197 GDIQVGM--MDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVAR 1254
G+IQ + ++ +L V + + + L K PYVK YLL + + KKKT V +
Sbjct: 631 GNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVK 690
Query: 1255 KTLEPLYQQLLSFEESPQ---GKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSN 1307
KTL P+Y ++L ++ Q + L + +W SF+G ++ L+ + N
Sbjct: 691 KTLNPVYNEILRYKIEKQILKTQKLNLSIW-HRDTFKRNSFLGEVELDLETWDWDN 745
>gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]
Length = 934
Score = 66.2 bits (160), Expect = 2e-10
Identities = 47/181 (25%), Positives = 89/181 (49%), Gaps = 8/181 (4%)
Query: 694 SSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSSQSLSRRTTPFVPRVQIKLWF 753
+S SS++ + + S+T+ S + + +S S +Q + +
Sbjct: 579 ASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEY 638
Query: 754 DKVGHQLIVTILGAKDLPSREDGRPRN-PYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQ 812
+ +L V + KDL + + + R+ PYVK Y LPD+ K++T VKKTL P +N+
Sbjct: 639 VESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNE 698
Query: 813 TFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPH----WYKL 868
Y + ++ + + L +++W R + + FLGE+ ++LET D++ + WY L
Sbjct: 699 ILRYK-IEKQILKTQKLNLSIWH--RDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPL 755
Query: 869 Q 869
+
Sbjct: 756 K 756
Score = 53.5 bits (127), Expect = 1e-06
Identities = 30/88 (34%), Positives = 47/88 (53%), Gaps = 4/88 (4%)
Query: 769 DLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERM 828
DLP G N +VK LPD S K++++T+ V KT P +N T +Y + E
Sbjct: 803 DLPLLR-GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEAC 861
Query: 829 LEITLWDQARVREEESEFLGEILIELET 856
+E+T+WD ++ ++FLG + I T
Sbjct: 862 VELTVWDHYKL---TNQFLGGLRIGFGT 886
Score = 48.9 bits (115), Expect = 3e-05
Identities = 33/116 (28%), Positives = 57/116 (49%), Gaps = 6/116 (5%)
Query: 1197 GDIQVGM--MDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVAR 1254
G+IQ + ++ +L V + + + L K PYVK YLL + + KKKT V +
Sbjct: 630 GNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVK 689
Query: 1255 KTLEPLYQQLLSFEESPQ---GKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSN 1307
KTL P+Y ++L ++ Q + L + +W SF+G ++ L+ + N
Sbjct: 690 KTLNPVYNEILRYKIEKQILKTQKLNLSIW-HRDTFKRNSFLGEVELDLETWDWDN 744
>gi|46255068 synaptotagmin-like 2 isoform f [Homo sapiens]
Length = 365
Score = 66.2 bits (160), Expect = 2e-10
Identities = 47/181 (25%), Positives = 89/181 (49%), Gaps = 8/181 (4%)
Query: 694 SSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSSQSLSRRTTPFVPRVQIKLWF 753
+S SS++ + + S+T+ S + + +S S +Q + +
Sbjct: 10 ASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEY 69
Query: 754 DKVGHQLIVTILGAKDLPSREDGRPRN-PYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQ 812
+ +L V + KDL + + + R+ PYVK Y LPD+ K++T VKKTL P +N+
Sbjct: 70 VESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNE 129
Query: 813 TFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPH----WYKL 868
Y + ++ + + L +++W R + + FLGE+ ++LET D++ + WY L
Sbjct: 130 ILRYK-IEKQILKTQKLNLSIWH--RDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPL 186
Query: 869 Q 869
+
Sbjct: 187 K 187
Score = 53.5 bits (127), Expect = 1e-06
Identities = 30/88 (34%), Positives = 47/88 (53%), Gaps = 4/88 (4%)
Query: 769 DLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERM 828
DLP G N +VK LPD S K++++T+ V KT P +N T +Y + E
Sbjct: 234 DLPLLR-GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEAC 292
Query: 829 LEITLWDQARVREEESEFLGEILIELET 856
+E+T+WD ++ ++FLG + I T
Sbjct: 293 VELTVWDHYKL---TNQFLGGLRIGFGT 317
Score = 48.9 bits (115), Expect = 3e-05
Identities = 33/116 (28%), Positives = 57/116 (49%), Gaps = 6/116 (5%)
Query: 1197 GDIQVGM--MDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVAR 1254
G+IQ + ++ +L V + + + L K PYVK YLL + + KKKT V +
Sbjct: 61 GNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVK 120
Query: 1255 KTLEPLYQQLLSFEESPQ---GKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSN 1307
KTL P+Y ++L ++ Q + L + +W SF+G ++ L+ + N
Sbjct: 121 KTLNPVYNEILRYKIEKQILKTQKLNLSIW-HRDTFKRNSFLGEVELDLETWDWDN 175
>gi|46255066 synaptotagmin-like 2 isoform e [Homo sapiens]
Length = 376
Score = 66.2 bits (160), Expect = 2e-10
Identities = 47/181 (25%), Positives = 89/181 (49%), Gaps = 8/181 (4%)
Query: 694 SSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSSQSLSRRTTPFVPRVQIKLWF 753
+S SS++ + + S+T+ S + + +S S +Q + +
Sbjct: 21 ASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEY 80
Query: 754 DKVGHQLIVTILGAKDLPSREDGRPRN-PYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQ 812
+ +L V + KDL + + + R+ PYVK Y LPD+ K++T VKKTL P +N+
Sbjct: 81 VESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNE 140
Query: 813 TFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPH----WYKL 868
Y + ++ + + L +++W R + + FLGE+ ++LET D++ + WY L
Sbjct: 141 ILRYK-IEKQILKTQKLNLSIWH--RDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPL 197
Query: 869 Q 869
+
Sbjct: 198 K 198
Score = 53.5 bits (127), Expect = 1e-06
Identities = 30/88 (34%), Positives = 47/88 (53%), Gaps = 4/88 (4%)
Query: 769 DLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERM 828
DLP G N +VK LPD S K++++T+ V KT P +N T +Y + E
Sbjct: 245 DLPLLR-GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEAC 303
Query: 829 LEITLWDQARVREEESEFLGEILIELET 856
+E+T+WD ++ ++FLG + I T
Sbjct: 304 VELTVWDHYKL---TNQFLGGLRIGFGT 328
Score = 48.9 bits (115), Expect = 3e-05
Identities = 33/116 (28%), Positives = 57/116 (49%), Gaps = 6/116 (5%)
Query: 1197 GDIQVGM--MDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVAR 1254
G+IQ + ++ +L V + + + L K PYVK YLL + + KKKT V +
Sbjct: 72 GNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVK 131
Query: 1255 KTLEPLYQQLLSFEESPQ---GKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSN 1307
KTL P+Y ++L ++ Q + L + +W SF+G ++ L+ + N
Sbjct: 132 KTLNPVYNEILRYKIEKQILKTQKLNLSIW-HRDTFKRNSFLGEVELDLETWDWDN 186
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,045,123
Number of Sequences: 37866
Number of extensions: 2911136
Number of successful extensions: 18447
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 204
Number of HSP's successfully gapped in prelim test: 563
Number of HSP's that attempted gapping in prelim test: 14222
Number of HSP's gapped (non-prelim): 4174
length of query: 1349
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1235
effective length of database: 13,930,794
effective search space: 17204530590
effective search space used: 17204530590
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.