Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 153791497
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
(2017 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 3733 0.0
gi|21735548 centrosomal protein 2 [Homo sapiens] 676 0.0
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 266 2e-70
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 266 2e-70
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 266 2e-70
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 266 2e-70
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 266 2e-70
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 266 2e-70
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 266 2e-70
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 266 2e-70
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 255 4e-67
gi|148746195 trichohyalin [Homo sapiens] 248 4e-65
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 222 3e-57
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 211 6e-54
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 209 3e-53
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 209 3e-53
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 209 3e-53
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 206 1e-52
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 205 4e-52
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 205 4e-52
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 205 4e-52
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 205 4e-52
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 204 7e-52
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 203 2e-51
gi|55770834 centromere protein F [Homo sapiens] 198 4e-50
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 190 1e-47
gi|81295809 pericentrin [Homo sapiens] 188 5e-47
gi|71061468 centromere protein E [Homo sapiens] 186 2e-46
gi|156104908 myosin heavy chain 6 [Homo sapiens] 186 2e-46
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 184 1e-45
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 3733 bits (9680), Expect = 0.0
Identities = 2017/2017 (100%), Positives = 2017/2017 (100%)
Query: 1 MSLGLARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLS 60
MSLGLARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLS
Sbjct: 1 MSLGLARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLS 60
Query: 61 QPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQ 120
QPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQ
Sbjct: 61 QPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQ 120
Query: 121 ALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKI 180
ALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKI
Sbjct: 121 ALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKI 180
Query: 181 LQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLR 240
LQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLR
Sbjct: 181 LQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLR 240
Query: 241 EQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLW 300
EQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLW
Sbjct: 241 EQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLW 300
Query: 301 RQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQ 360
RQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQ
Sbjct: 301 RQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQ 360
Query: 361 ALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVN 420
ALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVN
Sbjct: 361 ALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVN 420
Query: 421 KDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADAS 480
KDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADAS
Sbjct: 421 KDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADAS 480
Query: 481 NGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRG 540
NGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRG
Sbjct: 481 NGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRG 540
Query: 541 RYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANEL 600
RYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANEL
Sbjct: 541 RYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANEL 600
Query: 601 LSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRE 660
LSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRE
Sbjct: 601 LSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRE 660
Query: 661 LERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVEL 720
LERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVEL
Sbjct: 661 LERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVEL 720
Query: 721 ELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEA 780
ELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEA
Sbjct: 721 ELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEA 780
Query: 781 TVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLS 840
TVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLS
Sbjct: 781 TVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLS 840
Query: 841 RQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEAT 900
RQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEAT
Sbjct: 841 RQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEAT 900
Query: 901 RLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQE 960
RLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQE
Sbjct: 901 RLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQE 960
Query: 961 KASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQL 1020
KASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQL
Sbjct: 961 KASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQL 1020
Query: 1021 QREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMG 1080
QREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMG
Sbjct: 1021 QREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMG 1080
Query: 1081 TRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQE 1140
TRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQE
Sbjct: 1081 TRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQE 1140
Query: 1141 QARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGE 1200
QARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGE
Sbjct: 1141 QARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGE 1200
Query: 1201 LRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKE 1260
LRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKE
Sbjct: 1201 LRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKE 1260
Query: 1261 AGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKES 1320
AGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKES
Sbjct: 1261 AGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKES 1320
Query: 1321 RRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQ 1380
RRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQ
Sbjct: 1321 RRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQ 1380
Query: 1381 LDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSAL 1440
LDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSAL
Sbjct: 1381 LDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSAL 1440
Query: 1441 RRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASP 1500
RRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASP
Sbjct: 1441 RRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASP 1500
Query: 1501 DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAV 1560
DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAV
Sbjct: 1501 DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAV 1560
Query: 1561 AESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQ 1620
AESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQ
Sbjct: 1561 AESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQ 1620
Query: 1621 EKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQ 1680
EKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQ
Sbjct: 1621 EKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQ 1680
Query: 1681 ALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSA 1740
ALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSA
Sbjct: 1681 ALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSA 1740
Query: 1741 SLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVAD 1800
SLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVAD
Sbjct: 1741 SLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVAD 1800
Query: 1801 LELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAE 1860
LELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAE
Sbjct: 1801 LELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAE 1860
Query: 1861 KREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEA 1920
KREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEA
Sbjct: 1861 KREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEA 1920
Query: 1921 QRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHR 1980
QRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHR
Sbjct: 1921 QRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHR 1980
Query: 1981 QRVRGLEEQVSTLKGQLQQELRRSSAPFSPPSGPPEK 2017
QRVRGLEEQVSTLKGQLQQELRRSSAPFSPPSGPPEK
Sbjct: 1981 QRVRGLEEQVSTLKGQLQQELRRSSAPFSPPSGPPEK 2017
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 676 bits (1743), Expect = 0.0
Identities = 572/1950 (29%), Positives = 954/1950 (48%), Gaps = 207/1950 (10%)
Query: 137 LVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLE 196
L Q + L++Q+ E QA+ RKL+ QE QQRQA LV++LQ K+LQY+ C ELE++L E
Sbjct: 20 LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRL-E 78
Query: 197 RSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSED 256
+G QR + E +L+ L+RLEEEQQR SLA+VN LR +++A N+AL ED
Sbjct: 79 ATGGPIPQRWENVEEP-NLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALRED 137
Query: 257 IRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMF 316
+ K+T DW+R R EL +E+ W+ E+E F Y EH RLL LWR+VV FRR E+K
Sbjct: 138 VEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSA 197
Query: 317 TERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALE-----KQALLQAQLEEQL 371
T+RDL++L E R S ++ L L+ G + E ++ + LL A+ +E
Sbjct: 198 TDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELE 257
Query: 372 RDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALE 431
++ R ++L Q + Q DL+KA+L RVTEL + + +KQN + +++ K L E +E LE
Sbjct: 258 KEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILE 317
Query: 432 SLR---LQEQAALE---TEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLR 485
+ ++ +A+L E+ LQQ ++D+ Q ++ + ++ Q SG E + + +
Sbjct: 318 TNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFS 377
Query: 486 GLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEAS 545
Q L L+ S L +R+ VQD+R +
Sbjct: 378 QFDYQ-------------------------DADKALTLVRSVLTRRRQAVQDLRQQLAGC 412
Query: 546 QDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREK 605
Q+ + L++Q E E +AL ++LQ+L + D D Q EV L ELL + +
Sbjct: 413 QEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAR 472
Query: 606 SNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSH 665
L L+V +Q+A LR+ +LQ + + Q++ +EE AV RE ER
Sbjct: 473 EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAV-------RERERLQ 525
Query: 666 RQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMT 725
L LE K+S EL+ +REAL + L+ ++L+ E+ EV AL +AE EL S
Sbjct: 526 EMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSEN 585
Query: 726 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVARE 785
L+ E A L+ + KLSALNE+LA DK+ LN+ + QLEEE ++ R AEQ +
Sbjct: 586 TLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQV 645
Query: 786 EQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSG 845
+ E+ R LE L+ AE+A L+ L ++ E+ ++Q++L++ Q
Sbjct: 646 DLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEA 705
Query: 846 REQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLE 905
+LEQ +EA+RQ E L RA +EKEAL +E A L V+L A ER+ + L+E+ L
Sbjct: 706 ATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSA 765
Query: 906 KEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLD 965
KE LE SLFE Q+Q + +E + QLE + Q + AKE + GE+ L+ ++ + +A +
Sbjct: 766 KELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQE 825
Query: 966 KELMAQKLVQAEREAQASLREQRAAHEEDLQRLQR--EKEAAWRELEAERAQLQSQLQRE 1023
++ A++L QAE+E + +L +Q+AAHE+++ +L+ EKE +W + E +A L+S L+RE
Sbjct: 826 RDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKA-LES-LERE 883
Query: 1024 QEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRH 1083
+ EL RL+ ++ E+ A+Q +R+E AES Q E E+ +L E L+ T+
Sbjct: 884 KMELEMRLKEQQTEME----AIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQK 939
Query: 1084 SLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQAR 1143
LA S ++ER ++D + ++ +++ T L ++L++ + + +EAA H ++ LQE++
Sbjct: 940 ELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESS 999
Query: 1144 DLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRR 1203
L + + ++ E+L++QL +D++ + +E+ Q KLRE+QE +Q
Sbjct: 1000 SLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEV---QEKLRETQEYNRIQ--------- 1047
Query: 1204 SLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGE 1263
K+ E E+ SL L+ +KEQ+L +L+EA + +E
Sbjct: 1048 -----------------------KELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSA 1084
Query: 1264 LRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESR-- 1321
LR +QE + + E +++ LR+++K + E L +E A+L L E++ R
Sbjct: 1085 LRQDMQEAQGEQKELSAQMELLRQEVK--EKEADFLAQE-AQLLEELEASHITEQQLRAS 1141
Query: 1322 -----RETLGLRQRLLKGEASLEVMRQELQVA-QRKLQEQEGEFRTRERRLLGSLEEARG 1375
+ L+ RL E+ LE + E Q Q + Q Q + ++ LGS+ E+R
Sbjct: 1142 LWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRP 1201
Query: 1376 TEKQQLDHAR---GLELKLEAARAEAAE----LGLRLSAAEGRAQGLEAELARVEVQRRA 1428
D A GLE AR+ L A L +L + + R
Sbjct: 1202 ELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDV 1261
Query: 1429 AEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQP 1488
Q+ L L + A + + +D + S + S E S
Sbjct: 1262 LRDQVQKLEERL--------TDTEAEKSQVHTELQDLQRQLS-QNQEEKSKWEGKQNS-- 1310
Query: 1489 PSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDS 1548
L+ E + L E + L+S R R EL+ + R+L ++A +++
Sbjct: 1311 -------------LESELME--LHETMASLQSRLR-RAELQRMEAQGEREL--LQAAKEN 1352
Query: 1549 ATSRARQLQKAVAESE---EARRSVDGRLSGVQAELALQEESVRRSERERRATLD----- 1600
T++ LQ AV E+ A ++ L ++ L L+ E V SERER L
Sbjct: 1353 LTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEV-ESERERAQALQEQGEL 1411
Query: 1601 ---QVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDA----SESRTVK 1653
Q L+ +L L +E++ ++ +LE + K L+ + R +
Sbjct: 1412 KVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQE 1471
Query: 1654 LELQRRSLEGELQRSR-------LGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLT 1706
++LQ+ ++ EL++ R + + +RE + ++++ L++ D E + L+
Sbjct: 1472 VDLQQEQIQ-ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEK---DRETQRNVLEHQ 1527
Query: 1707 VERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQV- 1765
+ L +E G ++D + L L + L K QK + E R+
Sbjct: 1528 LLELEKKDQMIESQRGQVQDLKKQLV-TLECLALELEENHHKMECQQKLIKELEGQRETQ 1586
Query: 1766 ----------LQER---LDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQL 1812
L+ER L A + + S+ L ++Q EV Q E + Q
Sbjct: 1587 RVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQK 1646
Query: 1813 QQLREVLRQRQEGEAAALNTVQKLQDER----RLLQERLGSL-------------QRALA 1855
+ L + L +R + +Q L+D+R ++L+E L + QR L
Sbjct: 1647 EHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLM 1706
Query: 1856 QLEAEKREVERSALR--LEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGA 1913
Q AE+ + A R LE ++ LR +VE ++ HE L K +L++ L G
Sbjct: 1707 QERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHE----LQELKDQLEQQLQGL 1762
Query: 1914 ELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLE 1973
++ E + Q E ++VVL+Q A+ + + ++Q LQ +++ + A AQ ++ LE
Sbjct: 1763 HRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ--SLQSQLDEAQRALAQRDQELE 1820
Query: 1974 ARERAHRQRVRGLEEQV----STLKGQLQQ 1999
A ++ +Q+ +G EE+V L+G L+Q
Sbjct: 1821 ALQQ-EQQQAQGQEERVKEKADALQGALEQ 1849
Score = 290 bits (742), Expect = 1e-77
Identities = 469/1987 (23%), Positives = 848/1987 (42%), Gaps = 255/1987 (12%)
Query: 71 TEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERL--------EQAL 122
TE+ + L+ E++ ELS E+ L A+ A+K +A++E L +Q L
Sbjct: 564 TEVTAALARAEQSIA---ELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLL 620
Query: 123 RLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQ 182
+LE E Q + + + R LQ + A ++ +A E L+ ++ +
Sbjct: 621 QLEE---ENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTH-------LEAQLQK 670
Query: 183 YKKRCSELEQQLLERSGELE--QQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLR 240
++ +EL+ L + E E Q++L ++ H Q E+A +LE+ Q + +V A
Sbjct: 671 AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQ--EAATTQLEQLHQEAKRQEEVLARAV 728
Query: 241 EQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEES-FNAYFSNEHSRLLLL 299
++ + AL ++ V D ++L+ +A E S F A ++S + +
Sbjct: 729 QEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEA--QQQNSVIEVT 786
Query: 300 WRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEK 359
Q+ + V++ K + ++ L EL ++ + L AE + ALE+
Sbjct: 787 KGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQ 846
Query: 360 QALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQV 419
Q + QLR+K +E+ QQ++ L+ + E+ RL++Q E + +
Sbjct: 847 QKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEM-----RLKEQQTEMEAI 901
Query: 420 NKDLTEKLEALESLRLQEQAALETEDG---EGLQQTLRDLAQAVLSDSESGVQLSGSERT 476
E+ ES Q Q E E E L QT ++LA A + +
Sbjct: 902 QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK 961
Query: 477 ADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQ 536
+ G L Q +R R R + +SS+L L K QV+
Sbjct: 962 EQETTGIL-----QTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQK---QVE 1013
Query: 537 DMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRS 596
D++ + A D S+R +E ++LR+ Q + Q+E++R ++
Sbjct: 1014 DLKSQLVAQDD-------------SQRLVEQEVQEKLRET-----QEYNRIQKELEREKA 1055
Query: 597 ANELLSREKSNLAHSLQVA----QQQAEELRQEREKLQAAQEELRRQ----RDRLEEEQE 648
+ L EK LQ A QQ+ LRQ+ ++ Q Q+EL Q R ++E++
Sbjct: 1056 SLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEA 1115
Query: 649 DAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAE 708
D + A++ ELE SH +QL + +++ L Q + L AE+ +
Sbjct: 1116 DFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQ 1175
Query: 709 ALTKAEAGRVELEL-----SMTKLRAEEASLQDSLSKLSAL--NESLAQDKLDLNRLVAQ 761
A +A+ + L S+ + R E + DS + L +++ A+ L+
Sbjct: 1176 AQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTA 1235
Query: 762 LEEEK--SALQGRQR---QAEQEATVAREEQERLEELRLEQEVAR-------QGLEGSLR 809
L E SAL + + +Q V R++ ++LEE + E + Q L+ L
Sbjct: 1236 LSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLS 1295
Query: 810 VAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAR 869
++ + E + +L E +L E +A L +L R EL+ R EAQ + E L+ AA+
Sbjct: 1296 QNQEEKSKWEGKQNSLESELMELHETMASLQSRL--RRAELQ--RMEAQGERELLQ-AAK 1350
Query: 870 EKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ-LEARRE 928
E EH AV A+ + EE R L+ E +R+ AQ L+ + E
Sbjct: 1351 ENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGE 1410
Query: 929 QLEAEGQAL-----LLAK---------ETLTGELAGL---RQQIIATQEKASLDKEL--- 968
A+G+AL LL + ETL G++ L R+ A E SLD +
Sbjct: 1411 LKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQ 1470
Query: 969 ---MAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQRE-- 1023
+ Q+ +Q + ++ L A +E Q+L ++E RELE +R ++ L+ +
Sbjct: 1471 EVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQI-RELEKDRETQRNVLEHQLL 1529
Query: 1024 ----QEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLM 1079
+++++ + ++L +++ L E L L E + ++ L +
Sbjct: 1530 ELEKKDQMIESQRGQVQDLKKQLVTL-----ECLALELEENHHKMECQQKLIKELEGQRE 1584
Query: 1080 GTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQ 1139
R +L ++L++E + ++ Q++ Q + T R+L+ +R++ + +++ LQ
Sbjct: 1585 TQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQ-ERDQEVKSQREQIEELQ 1643
Query: 1140 EQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE--AQRKLRESQEGREV--QR 1195
Q L + + +E + ++++LED R + L E Q KL + GRE+ QR
Sbjct: 1644 RQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQR 1703
Query: 1196 QEAGELRRSLGEGAK--EREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEA 1253
Q E R G+G +R +L LR K+ E ++ + E K+Q LE+
Sbjct: 1704 QLMQE-RAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQ----LEQQ 1758
Query: 1254 RTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALG 1313
+ ++ GE L + E+ + +++LQE R Q ++ + LQ +L
Sbjct: 1759 LQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQS----------LQSQLDEA 1808
Query: 1314 ERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA 1373
+RA L + + LE ++QE Q++ Q QE + + L G+LE+A
Sbjct: 1809 QRA--------------LAQRDQELEALQQE----QQQAQGQEERVKEKADALQGALEQA 1850
Query: 1374 RGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQL 1433
T K++ H + K +A R E L+ R Q LE L + + R E L
Sbjct: 1851 HMTLKER--HGELQDHKEQARRLEE-----ELAVEGRRVQALEEVLGDLRAESREQEKAL 1903
Query: 1434 GGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGP 1493
L+ A V +D+ + LE S
Sbjct: 1904 LALQQQC--------AEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRH- 1954
Query: 1494 ATSPASPDLDPEAVRG---ALREFLQELRSAQRERDELRTQTSALNRQL----AEMEAER 1546
EA R AL+E L + +A + +++ + + L+R L A ++A
Sbjct: 1955 ---------QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASL 2005
Query: 1547 DSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLE 1606
D+ + +RQL++A+ E + D R Q ++ ++++ + + E R ++ LE
Sbjct: 2006 DACQAHSRQLEEALRIQEGEIQDQDLRY---QEDVQQLQQALAQRDEELRHQQEREQLLE 2062
Query: 1607 RSLQATESELRASQEKISKMKANETKLEGDKRRLKEV-LDASESRTVKLELQRRSLEGEL 1665
+SL E +++ + E ++ G + ++E+ L ++ LEL+ L
Sbjct: 2063 KSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNL 2122
Query: 1666 QRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR 1725
+ + Q+L ++DSL+ + LQ +ERL AL + E E R
Sbjct: 2123 EALPHSHKTSPMEEQSL--KLDSLEPR----------LQRELERLQAALRQTEAREIEWR 2170
Query: 1726 DKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSS 1785
+K + L +LAQ+ AS++S ++ + LQ ++ + ++Q LQ+ L+ R+AL + R S
Sbjct: 2171 EKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSP 2230
Query: 1786 SLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQE 1845
G + EL +G QL EV E + E++ ++
Sbjct: 2231 ----------GATSTAELGSRGEQG--VQLGEVSGVEAEPSPDGM--------EKQSWRQ 2270
Query: 1846 RLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGR 1905
RL LQ+A+A+L E++RS RL++ V LR TL++VERE+ + + +R +A+ G
Sbjct: 2271 RLEHLQQAVARL-----EIDRS--RLQRHNVQLRSTLEQVERERRKLKREAMR-AAQAGS 2322
Query: 1906 LDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVER---LR 1962
L+ + A + R + +A+ V + Q EV Q QL L+++ ++ R
Sbjct: 2323 LEISKATASSPTQQDGRGQKNSDAKCV------AELQKEVVLLQAQLTLERKQKQDYITR 2376
Query: 1963 SAQAQTE 1969
SAQ E
Sbjct: 2377 SAQTSRE 2383
Score = 289 bits (739), Expect = 2e-77
Identities = 485/2067 (23%), Positives = 879/2067 (42%), Gaps = 323/2067 (15%)
Query: 8 AQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPESPVL 67
AQE +L+L+ VI+ + + V+ +E ++AQ + + L I ++ Q L
Sbjct: 334 AQEEKLSLQQVIKDI-TQVMVEE----GDNIAQGSGHENSLELDSSIFSQFDYQDADKAL 388
Query: 68 LPATEMASLLSLQEEN-QLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEP 126
T + S+L+ + + Q L+Q+L+ ++ + + + D+ + A+ +RL++
Sbjct: 389 ---TLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLT---- 441
Query: 127 GELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKR 186
GE +T L Q+V+L Q E S ++ + Q+ ++ Q ++ L+ + + ++
Sbjct: 442 GERDT-----LAGQTVDL----QGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRV 492
Query: 187 CSELEQQLLERSGELEQQR------LRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLR 240
EL+ Q G+ E+Q+ +R+ E Q++ L E ++S SL+++ LR
Sbjct: 493 NVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGL-----EAKQSESLSEL-ITLR 546
Query: 241 EQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLW 300
E L+ + + L ++ +VT AA R E+S S+E++ L
Sbjct: 547 EALESSHLEGELLRQEQTEVT--------------AALARAEQSIAELSSSENT----LK 588
Query: 301 RQVVGFRRLVSEVKMFTE----------RDLLQLGGE---LARTSRAVQEAGLGLSTGLR 347
+V R ++ E + LLQL E + A ++A L L
Sbjct: 589 TEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLA 648
Query: 348 LAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVK 407
AE R EA EK L+AQL++ + DL Q + + + LS + A
Sbjct: 649 EAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATT 708
Query: 408 RLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESG 467
+LE+ + E + + L ++ E+L ++E+AALE + +++ +DLA+ + S +
Sbjct: 709 QLEQLHQEAKRQEEVLARAVQEKEAL-VREKAALEVRL-QAVERDRQDLAEQLQGLSSAK 766
Query: 468 VQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSA 527
L S A N + GQ
Sbjct: 767 ELLESSLFEAQQQNSVIEVTKGQL------------------------------------ 790
Query: 528 LHKRQLQVQDMRGRYEASQDLLGTLRKQL----SDSESERRALEEQLQRLRDKTDGAMQA 583
++Q+Q + E Q + L+ +L S +E ER A QL + + A++
Sbjct: 791 ----EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQ 846
Query: 584 HEDA-QREVQRLRSANEL-LSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRD 641
+ A ++EV +LR E S + LA +L+ +++ EL ++ Q E ++ QR
Sbjct: 847 QKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQR- 905
Query: 642 RLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQA 701
EEE+ A + A + +LE ++ LE KEL + + L R L++DM
Sbjct: 906 --EEERTQA--ESALCQMQLETEKERVSLLETLLQT-QKELADASQQLER--LRQDM--- 955
Query: 702 EKAEVAEALTKAEAGRVELELSMTKLRAEEASLQ--DSLSKLSALNESLAQDKLDLNRLV 759
+V + + G ++ +L + +EA+ Q D L+ L + SL QDK+DL + V
Sbjct: 956 ---KVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQV 1012
Query: 760 AQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALE 819
L+ + A QR EQE V + +E E R+++E+ R+ +L + E+ E
Sbjct: 1013 EDLKSQLVAQDDSQRLVEQE--VQEKLRETQEYNRIQKELEREKASLTLSLMEK-----E 1065
Query: 820 QQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEA--LAKE 877
Q+L L+ S Q++L+ L + + QE + ++E Q+E L + +EKEA LA+E
Sbjct: 1066 QRLLVLQEADSIRQQELSALRQDM----QEAQGEQKELSAQMELLRQEVKEKEADFLAQE 1121
Query: 878 HAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQ-- 935
QL+ E E ++E+ +LR A E ++Q +L E++ E L AE Q
Sbjct: 1122 -----AQLLE-ELEASHITEQ--QLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPG 1173
Query: 936 ----------ALLLAKETLTGELAGLRQQIIATQEKA----SLDKELMAQKLVQAEREAQ 981
+L A + G + R ++ + A L+ + + +
Sbjct: 1174 NQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLL 1233
Query: 982 ASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEE 1041
+L + A L + + W+ + R L+ Q+Q+ EE L EAEK ++ E
Sbjct: 1234 TALSAEAVA-----SALHKLHQDLWKTQQT-RDVLRDQVQK-LEERLTDTEAEKSQVHTE 1286
Query: 1042 IAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMER---QKRD 1098
+ LQ++ S+ Q+ S E ++ +L +LM ++A++ + R Q+ +
Sbjct: 1287 LQDLQRQL--------SQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRME 1338
Query: 1099 AQSRQEQDRSTVNALTSELRDLRAQREEAAAAHA--------------------QEVRRL 1138
AQ +E ++ LT+++ L+A EA A + +EV
Sbjct: 1339 AQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESE 1398
Query: 1139 QEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEA 1198
+E+A+ L +Q + + + + L+ L LL E+ + +++E ++ RE+Q+
Sbjct: 1399 RERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAAL 1458
Query: 1199 GELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVG 1258
L L + +E + + +EL +K S L +A +++EQKL + E +
Sbjct: 1459 ELLSLDLKKRNQEVDLQQEQIQEL----EKCRSVLEHLPMAVQEREQKLTVQREQIRELE 1514
Query: 1259 KEAGELRTGLQ------EVERSRLEARR-ELQELRRQMKMLDSENTRLGRELAELQGRLA 1311
K+ R L+ E + +E++R ++Q+L++Q+ L+ L EL E ++
Sbjct: 1515 KDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLEC----LALELEENHHKME 1570
Query: 1312 LGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLE 1371
++ KE + R L LE QELQ ++ + E R L +
Sbjct: 1571 CQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAREL----Q 1626
Query: 1372 EARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEA 1431
E K Q + L+ + E + L + R Q LE + R Q + E
Sbjct: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTR---QTKILEE 1683
Query: 1432 QLGGLRSALR-RGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPS 1490
L ++ +LR RG L + R E + EG
Sbjct: 1684 DLEQIKLSLRERGREL-------------TTQRQLMQERAEEG----------------- 1713
Query: 1491 PGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSAT 1550
GP+ +A RG+L LR ++E + E++ +D
Sbjct: 1714 KGPS----------KAQRGSLEHMKLILRDKEKE-------VECQQEHIHELQELKDQLE 1756
Query: 1551 SRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQ 1610
+ + L + V E+ + + +Q +L E E+ ++ LD+ +R+L
Sbjct: 1757 QQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEA---QRALA 1813
Query: 1611 ATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRL 1670
+ EL A Q++ + + +G + R+KE DA + + + + GELQ
Sbjct: 1814 QRDQELEALQQE-------QQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQ---- 1862
Query: 1671 GLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEE--SEGALRDKV 1728
D + QA+ L++ + R+V E G L+ AL +++ +E A +V
Sbjct: 1863 ---DHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEV 1919
Query: 1729 --RGLTEALAQSSASLNSTRDKNLHLQKALT-ACEHDRQVLQERLDAARQALSEARK--- 1782
R L ++ Q+ A L RD+ L +A + + H + + R +A ++AL +A
Sbjct: 1920 ETRALQDSWLQAQAVLKE-RDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQ 1978
Query: 1783 -QSSSLGEQVQ---TLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQD 1838
+ L EQ + +L A L+ + +QL E LR QEGE +QD
Sbjct: 1979 GKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRI-QEGE---------IQD 2028
Query: 1839 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKD---RVALRRTLDKVEREKLRSHED 1895
+ QE + LQ+ALAQ + E R + LEK RV +K + R E+
Sbjct: 2029 QDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEE 2088
Query: 1896 TVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQ---LEVDAQQQQL 1952
L L TL E E+ E + Q+ + + SP + L++D+ + +L
Sbjct: 2089 IRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRL 2148
Query: 1953 ELQQEVERLRSAQAQTE-RTLEARERA 1978
Q+E+ERL++A QTE R +E RE+A
Sbjct: 2149 --QRELERLQAALRQTEAREIEWREKA 2173
Score = 220 bits (561), Expect = 1e-56
Identities = 388/1669 (23%), Positives = 685/1669 (41%), Gaps = 193/1669 (11%)
Query: 5 LARA-QEVELTLETVIQTLESSV-LCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQP 62
LA+A QE + LE E V +EK R Q +L +L RE + +
Sbjct: 833 LAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLK 892
Query: 63 ESPVLLPATEMASLLSLQEENQL----------LQQELSRVEDLLAQSRAERDELAIKYN 112
E TEM ++ + +EE + L+ E RV LL + ELA
Sbjct: 893 EQQ-----TEMEAIQAQREEERTQAESALCQMQLETEKERVS-LLETLLQTQKELADASQ 946
Query: 113 AVSERLEQALRLEPGELETQEPRGLVR-QSVELRRQLQEEQASYRRKLQAYQEGQQRQAQ 171
+ ERL Q ++++ +L+ QE G+++ Q E +R+L+E +R L A QE Q
Sbjct: 947 QL-ERLRQDMKVQ--KLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003
Query: 172 LVQRLQGKILQYKKRCSE-------LEQQLLERSGELEQQRLRDTEHSQDLESALIRLEE 224
LQ ++ K + +EQ++ E+ E ++ E ++ S + L E
Sbjct: 1004 DKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME 1063
Query: 225 EQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEES 284
++QR L + +++ +++L AL +D+++ + +KEL + R+E +
Sbjct: 1064 KEQRLLVLQEADSIRQQELS-------ALRQDMQEAQGE----QKELSAQMELLRQEVKE 1112
Query: 285 FNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLG-LS 343
A F L E ++ E + + + R S QEA L
Sbjct: 1113 KEADF-------------------LAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ 1153
Query: 344 TGLRLAESRAEA-ALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTEL 402
LR ES+ EA A E+Q QAQ + QL QQ + S + +R
Sbjct: 1154 LRLRSTESQLEALAAEQQPGNQAQAQAQLASLY----SALQQALGSVCE-----SRPELS 1204
Query: 403 GLAVKRLEKQNLEKDQVN-KDLTEKLEALESLRLQEQAALETEDGEGLQQT--LRDLAQA 459
G LE DQ + L ++ L +L + A+ + + L +T RD+ +
Sbjct: 1205 GGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRD 1264
Query: 460 VLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSS-PGRGRSPRRGPSPACSDS 518
+ E +L+ +E + L+ L Q + + +S G+ S S
Sbjct: 1265 QVQKLEE--RLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLE---SELMELH 1319
Query: 519 STLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSES---ERRA-------LEE 568
T+A + S L + +LQ + +G E Q L Q+ ++ E RA LEE
Sbjct: 1320 ETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEE 1379
Query: 569 QLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREK 628
L+ R + E + Q L+ EL + L +L + Q E +E E
Sbjct: 1380 DLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVET 1439
Query: 629 LQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREA 688
L+ +EL +QR+ + E D + +E++ Q+++LE RSVL + V+E
Sbjct: 1440 LRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQER 1499
Query: 689 LSRATLQRDML----------------QAEKAEVAEALTKAEAGRV-ELELSMTKLRAEE 731
+ T+QR+ + Q + E + + +++ G+V +L+ + L
Sbjct: 1500 EQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLA 1559
Query: 732 ASLQDSLSKLSALNESLAQ-------DKLDLNRLVAQLEEEKSALQGRQRQ---AEQEAT 781
L+++ K+ + + + ++ L L LEE LQ + Q E +T
Sbjct: 1560 LELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHST 1619
Query: 782 V-AREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLS 840
V ARE QER +E++ + R+ +E R E + LE++ L ++ ++Q Q +
Sbjct: 1620 VLARELQERDQEVKSQ----REQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRT 1675
Query: 841 RQLSGREQELEQAR-------REAQRQVEALERAAREKEALAKEHAG----LAVQLVAAE 889
RQ E++LEQ + RE Q + ++ A E + +K G + + L E
Sbjct: 1676 RQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKE 1735
Query: 890 REGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ----LEARREQLEAEGQALLLAKETLT 945
+E E L+ K+ LE L + R++ + L R +++ Q L A+E
Sbjct: 1736 KEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGE 1795
Query: 946 GELAGLRQQIIATQEK-ASLDKELMAQKLVQAEREAQASLREQRAAHEED-LQRLQREKE 1003
+ L+ Q+ Q A D+EL A L Q +++AQ +E+R + D LQ +
Sbjct: 1796 LKEQSLQSQLDEAQRALAQRDQELEA--LQQEQQQAQG--QEERVKEKADALQGALEQAH 1851
Query: 1004 AAWRELEAERAQLQSQLQREQEELL--ARLEAEKEELSEEIAALQQERDEGLLLAESEKQ 1061
+E E + Q +R +EEL R EE+ ++ A +E+++ LL + +
Sbjct: 1852 MTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCA 1911
Query: 1062 QALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQD---RSTVNALTSELR 1118
+ E E AL + + + L E+E + ++QS + Q+ R+ AL L
Sbjct: 1912 EQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALG 1971
Query: 1119 DLRAQ---REEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRL----LEDARD 1171
A +E+ A+ R L+ L D+C + +L LR+ ++D
Sbjct: 1972 KAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL 2031
Query: 1172 GLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSN---EELRSAVKK 1228
+ ++ + Q+ L + E Q++ L +SL + +E + N E ++
Sbjct: 2032 RYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRG 2091
Query: 1229 AESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQ 1288
L+L KEQ++ L E + R L+ + S + E Q L+
Sbjct: 2092 LHQSVRELQLTLAQKEQEILELRET---------QQRNNLEALPHSHKTSPMEEQSLK-- 2140
Query: 1289 MKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVA 1348
LDS RL REL LQ L E E E R + L L + +AS+ +++
Sbjct: 2141 ---LDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFL 2197
Query: 1349 QRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAA 1408
Q + E++ E ++RL LE R +++ H+ G E E G++L
Sbjct: 2198 QASVLERDSE----QQRLQDELELTRRALEKERLHSPGATSTAEL--GSRGEQGVQL--- 2248
Query: 1409 EGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAE 1468
G G+EAE + +++++ +L L+ A+ R L + R S R + E
Sbjct: 2249 -GEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVAR-LEIDR--SRLQRHNVQLRSTLEQVE 2304
Query: 1469 GSGEGLNSPSTLECSPGSQPPSPGPATSPASPD------LDPEAVRGALREFL---QELR 1519
L + GS S A+SP D D + V +E + +L
Sbjct: 2305 RERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLT 2364
Query: 1520 SAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARR 1568
++++ + T+++ +R+LA + + Q +A E RR
Sbjct: 2365 LERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRR 2413
Score = 114 bits (284), Expect = 1e-24
Identities = 241/1108 (21%), Positives = 446/1108 (40%), Gaps = 185/1108 (16%)
Query: 964 LDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQRE 1023
L+++++A + AE +A AS R+ + + E Q+ + R+L+A+ Q +S Q
Sbjct: 20 LEEQVLALQQQMAENQA-ASWRKLKNSQEA-----QQRQATLVRKLQAKVLQYRSWCQ-- 71
Query: 1024 QEELLARLEA------------EKEELSEEIAALQQERDEGLLLAESEKQQALSLKESE- 1070
EL RLEA E+ L E + L++E+ LAE Q L +++++
Sbjct: 72 --ELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADV 129
Query: 1071 -KTALSEKLMGTRHSLATISLEMERQKRDAQSRQE-------QDRSTVNALTSELRDLRA 1122
AL E + + E+ R++ Q QE + + +L E+ R
Sbjct: 130 VNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRR 189
Query: 1123 QREEAAAAHAQEVRRLQ-EQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQ 1181
E +A +++ L+ E R G CLR +++ DG RE +
Sbjct: 190 HFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDG--REPAQLL 247
Query: 1182 RKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANE 1241
L ++QE + + + EL + +G E+ L+ EL + + +++ + NE
Sbjct: 248 LLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQ-------NE 300
Query: 1242 DKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGR 1301
D E+ + L E + EL + R+ E + LQ++ + + +
Sbjct: 301 DYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQV--------- 351
Query: 1302 ELAELQGRLALGERAEKESRRETLGLRQ-RLLKGEASLEVMRQELQVAQRKLQEQEGEFR 1360
+ E +A G E ++ Q + +L ++R L ++ +Q+
Sbjct: 352 -MVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDL----- 405
Query: 1361 TRERRLLGSLEEARGTEKQQLDH----ARGLELKLEAARAEAAELGLRLSAAEGRAQGLE 1416
R+ L +EA +QQ D + L +L+ E L + +G L
Sbjct: 406 ---RQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLS 462
Query: 1417 AELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNS 1476
E ++ R QL L R R + A+G E
Sbjct: 463 KERELLQKAREELRQQLEVLEQEAWR----------LRRVNVELQLQGDSAQGQKEEQQE 512
Query: 1477 PSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRER-DELRTQTSAL 1535
L R L+E L L + Q E EL T AL
Sbjct: 513 ELHLAVRE-----------------------RERLQEMLMGLEAKQSESLSELITLREAL 549
Query: 1536 NRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELA-LQEESVRRSERE 1594
E E R T ++ A+A +E++ + + ++ E+A L+ +V+ S
Sbjct: 550 ESSHLEGELLRQEQT----EVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALN 605
Query: 1595 RRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKL 1654
LD+V ++ LQ E +Q S+M+A E + L+ L +E R L
Sbjct: 606 EALALDKVGLNQQLLQLEEE----NQSVCSRMEAAEQA----RNALQVDLAEAEKRREAL 657
Query: 1655 ELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGAL 1714
+ LE +LQ++ ++ +A + +Q+ + +Q+++++S + +E+L+
Sbjct: 658 WEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEA 717
Query: 1715 AKVEESEG-ALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAA 1773
+ EE A+++K EAL + A+L + L A E DRQ L E+L
Sbjct: 718 KRQEEVLARAVQEK-----EALVREKAAL----------EVRLQAVERDRQDLAEQLQGL 762
Query: 1774 RQA-------LSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLR-----EVLRQ 1821
A L EA++Q+S + L ++ + + +G+++ L+ E +
Sbjct: 763 SSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQA 822
Query: 1822 RQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRT 1881
QE +AAA Q Q+ + L+++ + ++ + QL EK E ERS + E L +
Sbjct: 823 EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLR-EKWEKERSWHQQE-----LAKA 876
Query: 1882 LDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQ--------------- 1926
L+ +EREK+ E +RL ++ E+E +AQR+ ++
Sbjct: 877 LESLEREKM---ELEMRLKEQQ---------TEMEAIQAQREEERTQAESALCQMQLETE 924
Query: 1927 ----------LEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARE 1976
L+ Q + + S +L D + Q+L+ Q+ L++ + +R L+
Sbjct: 925 KERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984
Query: 1977 RAHRQRVRGLEEQVSTL---KGQLQQEL 2001
R HR + L+E+ S+L K LQ+++
Sbjct: 985 RQHRDDLAALQEESSSLLQDKMDLQKQV 1012
Score = 110 bits (275), Expect = 1e-23
Identities = 212/928 (22%), Positives = 369/928 (39%), Gaps = 106/928 (11%)
Query: 1118 RDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELR-TQLRLLEDARDGLRRE 1176
+ L+ EE A Q++ + QA K ++S +EA++ + T +R L+ R
Sbjct: 14 QSLQLVLEEQVLALQQQMA--ENQAASWRKLKNS--QEAQQRQATLVRKLQAKVLQYRSW 69
Query: 1177 LLEAQRKLRES-----QEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAES 1231
E +++L + Q V+ EL L E + E+L N +LR ++KA+
Sbjct: 70 CQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKAD- 128
Query: 1232 ERISLKLANEDKEQKLALLEEARTAVGKEAG------ELRTGLQEVERSRLEAR-RELQE 1284
+ K ED E+ AR + ++ E G + E RL + RE+
Sbjct: 129 --VVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVT 186
Query: 1285 LRRQMKMLDSENTRLGRELAELQGR-LALGERAEKESRRETLGLRQRLLKGEASLEVMRQ 1343
RR + S R +L EL+ + L R T+G + R G ++
Sbjct: 187 FRRHFLEMKSATDR---DLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREP 243
Query: 1344 -ELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQL-DHARGLELKLEAARAEAAEL 1401
+L + K QE E E R + L+ L+ EK +L D L L ++ + +
Sbjct: 244 AQLLLLLAKTQELEKEAHERSQELI-QLKSQGDLEKAELQDRVTELSALLTQSQKQNEDY 302
Query: 1402 GLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSP 1461
+ A + LE + EA L R+A L L + + +
Sbjct: 303 EKMIKALRETVEILETN----HTELMEHEASLS--RNAQEEKLSLQQVIKDITQVMVEEG 356
Query: 1462 ARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSA 1521
A G L S++ Q + +AV+ LR+ L + A
Sbjct: 357 DNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQD-LRQQLAGCQEA 415
Query: 1522 ----QRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGV 1577
Q++ D+ + AL ++L ++ ERD+ + LQ V + R + +
Sbjct: 416 VNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREEL 475
Query: 1578 QAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDK 1637
+ +L + E+ R R Q + + + + EL + + +++ LE
Sbjct: 476 RQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEA-- 533
Query: 1638 RRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSE 1697
K+ SE T++ L+ LEGEL R +E
Sbjct: 534 ---KQSESLSELITLREALESSHLEGELLRQE-------------------------QTE 565
Query: 1698 VKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALT 1757
V A + R ++A++ SE L+ +V L A + SA + + L + L
Sbjct: 566 VTAA-----LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLL 620
Query: 1758 ACEHDRQVLQERLDAARQA-------LSEARKQSSSLGEQVQTLRGEVADLELQRVEAEG 1810
E + Q + R++AA QA L+EA K+ +L E+ L ++ E EA
Sbjct: 621 QLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAE----EAGA 676
Query: 1811 QLQ-QLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSAL 1869
+LQ LR++ +++E +QK E R QE + L Q + EV A+
Sbjct: 677 ELQADLRDIQEEKEE--------IQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAV 728
Query: 1870 R----LEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQ 1925
+ L +++ AL L VER++ E LS+ K L+ +L A+ + + +
Sbjct: 729 QEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKG 788
Query: 1926 QLEAQVVVLEQSHSPAQ-------LEVDAQQQQLELQQEVERLRSAQAQTE--RTLEARE 1976
QLE Q+ + Q+ Q LE+D ++ Q E +++ + AQA+ E LE ++
Sbjct: 789 QLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQK 848
Query: 1977 RAHRQRVRGLEEQVSTLKGQLQQELRRS 2004
AH + V L E+ + QQEL ++
Sbjct: 849 AAHEKEVNQLREKWEKERSWHQQELAKA 876
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 266 bits (680), Expect = 2e-70
Identities = 459/1955 (23%), Positives = 813/1955 (41%), Gaps = 297/1955 (15%)
Query: 110 KYNAVSERLEQALR-LEPGELETQEPRGLVRQSVELRRQLQ--EEQASYRRKL------- 159
+Y + S +Q L+ LE G E + + + ++R QL+ E + +R +L
Sbjct: 957 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA 1016
Query: 160 ----QAYQEGQQRQAQL------VQRLQG---KILQYKK---RCSELEQQLLERSGELEQ 203
Q E Q+ QA++ V RL K+L + L +L G+LEQ
Sbjct: 1017 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1076
Query: 204 QR----------------LRDTEHSQD-LESALIRLEEEQQRSASLAQVNAM------LR 240
R +R T+ +++ L + +L+E Q A+L ++ A LR
Sbjct: 1077 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1136
Query: 241 EQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLW 300
Q + AL +++R R ++ R+ R E ++LL W
Sbjct: 1137 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERV--------AQLLERW 1188
Query: 301 RQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAES-RAEAALEK 359
+ V+ ++V+ +R+L QLG +L + G L R E +A +
Sbjct: 1189 QAVLA----QTDVR---QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1241
Query: 360 QALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQV 419
QA+ + +EQ + + ++ Q + + + EL L + + + +
Sbjct: 1242 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK 1301
Query: 420 NKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADA 479
+ E++ +QE L T E T +Q + SE+ ++ ER A+
Sbjct: 1302 KPKVQSGSESV----IQEYVDLRTHYSELTTLT----SQYIKFISETLRRMEEEERLAEQ 1353
Query: 480 SNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMR 539
QR R + +R + A + + A + ++++Q + +R
Sbjct: 1354 ----------QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 540 GRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANE 599
R EA+ D ++ ++R+++E+LQ+LR ++ +QA + R A E
Sbjct: 1404 -REEAAVD-----------AQQQKRSIQEELQQLRQSSEAEIQA---------KARQA-E 1441
Query: 600 LLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
R + + ++V + Q E ++R + + LR + + E ++ A ++ R+RR
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1501
Query: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRA--TLQRDMLQAEKAEVAEALTKAEAGR 717
+++ ++ Q E + + K E RA L+ LQAE+AE + E R
Sbjct: 1502 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Query: 718 VELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAE 777
T R+ EA LQ + + L + + + VAQL EE R+ Q +
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE----RRAQQQ 1617
Query: 778 QEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLA 837
EA AREE ER EL Q A + L L+ E AQ Q+ LA
Sbjct: 1618 AEAERAREEAER--ELERWQLKANEALRLRLQAEEVAQ-----------------QKSLA 1658
Query: 838 QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKE-------HAGLAVQLVAAER 890
Q E++ E+A REA+R+ +A E+A R++E +E G A Q +AAE+
Sbjct: 1659 QAEA-----EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 891 EGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAG 950
E L E + +++ LE L +QR+ A +R++LEAE + E L A
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 951 LRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELE 1010
++ +T EK+ E A + + EA R + A E QR E++AA + E
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAA---RLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 1011 AERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLL--LAESEKQQALSLKE 1068
AER E+L A EA + + EIA ++E + L LAE E Q L+E
Sbjct: 1831 AERVLA--------EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882
Query: 1069 S---EKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQRE 1125
K + E+L R + + E+ERQK + Q R + E+ L+A E
Sbjct: 1883 QAAQHKADIEERLAQLRKASDS---ELERQKGLVEDTLRQRRQ----VEEEILALKASFE 1935
Query: 1126 EAAAAHAQ---EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
+AAA A+ E+ R++ A D + ++ EA R QL E+ R RRE E +
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-QLAAEEERR---RREAEERVQ 1991
Query: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERI-SLKLANE 1241
K ++E QR+ A E E E L+ EE R ++AE E L+LA E
Sbjct: 1992 KSLAAEEEAARQRKAALE----------EVERLKAKVEEARRLRERAEQESARQLQLAQE 2041
Query: 1242 DKEQKLALLEEART-AVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLG 1300
+++L E+A AV ++ EL+ LQ+ + + R E + RR + + +
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2101
Query: 1301 RELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQEL-QVAQRKLQEQEGEF 1359
RE A+ + ++ ER ++ + + Q + +A+ E +R+E Q A R+ Q ++
Sbjct: 2102 REAAQSRRQVEEAERLKQSAEEQA----QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 1360 RTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAEL 1419
R ++ +E+ + +Q L +E +L R L+L + + L+ EL
Sbjct: 2158 RQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR-------LQLEETDHQKNLLDEEL 2209
Query: 1420 ARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPST 1479
R++ + A Q RS + L R
Sbjct: 2210 QRLKAEATEAARQ----RSQVEEELFSVR------------------------------- 2234
Query: 1480 LECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRE--RDELRTQTSALNR 1537
++ S+ + A + A D + + L+E ++++ E R + Q +A R
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 1538 QLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRA 1597
QLAE + + A + +K A E R + L Q ELA +E RR + ++
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA--QEQARRLQEDKEQ 2352
Query: 1598 TLDQVATLERSLQAT-------ESELRASQEK----ISKMKANETKLEGDKRRLKEVLDA 1646
Q+A + Q T + E+ A E+ +++M + + E D +R ++ +
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412
Query: 1647 SESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLT 1706
+ + EL + +Q + + A+ L++ + L+R+ + +A LQL
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL- 2471
Query: 1707 VERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNST---RDKNLHLQKALTACEHDR 1763
K EE + ++++ T+AL QS S + R++ + +KA
Sbjct: 2472 ---------KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL-----E 2517
Query: 1764 QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQ 1823
Q+ Q+ + A+Q E ++Q + ++ Q L VA +E EA + + E +R++Q
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASME----EARRRQHEAEEGVRRKQ 2570
Query: 1824 EGEAAALNTVQKLQDERR----LLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALR 1879
E +Q+L+ +RR LL E L+ L LE + R + + +VA
Sbjct: 2571 E-------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2623
Query: 1880 RTLDK---------VEREKLRSHEDTVR-LSAEKGRLDRTLTGAELE-LAEAQRQIQQLE 1928
+TL E E S + R +SA++ + L+ EL+ LA+ + +L
Sbjct: 2624 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2683
Query: 1929 AQVVV---LEQSHSPAQLEVDAQQQQLELQQEVER 1960
+ V L+ S A L + A ++L + ++R
Sbjct: 2684 RREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQR 2718
Score = 263 bits (673), Expect = 1e-69
Identities = 357/1544 (23%), Positives = 644/1544 (41%), Gaps = 172/1544 (11%)
Query: 543 EASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRS-ANELL 601
EA++ L LR Q + AL ++L+ ++ + Q H + EV+R R +LL
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1185
Query: 602 SREKSNLAHSLQVAQQQAEEL----RQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARV 657
R ++ LA + V Q++ E+L R RE L+ R R E+ Q + D V
Sbjct: 1186 ERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1244
Query: 658 RRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGR 717
R +L + LE++E EK E + K
Sbjct: 1245 REQLRQEQALLEEIER--------------------------HGEKVEECQRFAKQYINA 1278
Query: 718 V---ELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQL-----------E 763
+ EL+L K + E + K+ + +ES+ Q+ +DL ++L
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1338
Query: 764 EEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLP 823
E ++ +R AEQ+ EE+ERL E+ E RQ E + QA+ ++
Sbjct: 1339 ETLRRMEEEERLAEQQRA---EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395
Query: 824 TLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEA----LERAAREKEALAKEHA 879
++ E + +E +Q ++EL+Q R+ ++ +++A E A R + + +E
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 880 GLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEAR---REQLEAEGQA 936
+ +QL A ER+ E LR E E + Q + +L + Q + + +
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 937 LLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAE---------------REAQ 981
L ++ E A +Q+ + E+ L E ++L QAE R A+
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 982 ASLREQRAAHEEDLQRLQREKE------AAWRELEAERAQLQSQLQREQEELLARLEA-- 1033
A L+ +RA+ E +L+R + A RE RAQ Q++ +R +EE LE
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 1034 --EKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE 1091
E L + A + + + L AE+EKQ+ + +E+ + +E+ + LA LE
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1695
Query: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHA---QEVRRLQEQARDLGKQ 1148
+RQ + ++Q A EL LRA+ E+ +E+ RLQ +A ++
Sbjct: 1696 KQRQLAEGTAQQRL------AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1749
Query: 1149 RDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLR---ESQEGREVQRQEAGELRRSL 1205
R E ++R ++ +L ++ E K + E++ GR + E R+L
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809
Query: 1206 GEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELR 1265
E AK + L + +A ++AE+ER+ +KLA + EA K E+
Sbjct: 1810 AEEAKRQRQLAEED----AARQRAEAERVLA--------EKLAAIGEATRL--KTEAEIA 1855
Query: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETL 1325
+E E RL RR ++ Q + L+ + + A+++ RLA +A
Sbjct: 1856 LKEKEAENERL--RRLAEDEAFQRRRLEEQ---AAQHKADIEERLAQLRKASDSELERQK 1910
Query: 1326 GLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA-RGTEKQQLDHA 1384
GL + L+ +E L+ + K + E R+ + E+ R E+ +L+ A
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970
Query: 1385 RGLELKLEAARA--EAAE-LGLRLSAAEGRAQGLEAELARVE-VQRRAAEAQLGGLRSAL 1440
R +L E R EA E + L+A E A+ +A L VE ++ + EA+ R+
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2030
Query: 1441 RRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASP 1500
L A A + + A A E TL+ G A
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ-ELQQTLQQEQSVLDQLRGEA------ 2083
Query: 1501 DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNR--QLAEMEAERDSATSRARQLQK 1558
EA R A E + A+RE + R Q R Q AE +A+ + A + +
Sbjct: 2084 ----EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 1559 AVAESEEARRSVDGRLS-----GVQAELALQEESVRRSERERRATLDQVATLERSLQATE 1613
AE E ARR+ + + AE+ ++ ++ R++ ++ TL L+ T+
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 1614 SELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLS 1673
+ E++ ++KA T+ + +++E L + + +L + +E E L L
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE--NRALILR 2257
Query: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGA----LAKVEE-SEGALRDKV 1728
D++ + LQ+ + + +QVA+ + RL LA+ +E L++K+
Sbjct: 2258 DKDNTQRFLQEEAEKM-KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 1729 RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQ---ERLDAARQALSEARKQSS 1785
+ + EA + + + K L ++A E Q+ Q E ++ L R++
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 1786 SLGEQVQTLRGEVADLELQRVEAEGQLQQLR-------EVLRQRQEGEAAALNTVQKLQD 1838
+ + + L+ VA++ + AE Q+ R E L + + + VQ L+
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 1839 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR 1898
+R+ L+ A+A+LE EK ++++ A L+ + V++E+L
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQ------ 2486
Query: 1899 LSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV 1958
E L ++ + L + +R I+Q +A++ L Q ++ +QQ+ + Q E
Sbjct: 2487 ---ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 1959 ERLRSAQAQTERTLEARERAH--RQRVRGLEEQVSTLKGQLQQE 2000
ER R + EAR R H + VR +E++ L+ Q +Q+
Sbjct: 2544 ERQRLVASME----EARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2583
Score = 234 bits (597), Expect = 6e-61
Identities = 425/1785 (23%), Positives = 742/1785 (41%), Gaps = 230/1785 (12%)
Query: 116 ERLEQALRLEPGELETQEP-----RGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQA 170
E + +L+ + E Q+P R +R + E+ +LQ+ +++ ++E R A
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE---RVA 1182
Query: 171 QLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI---RLEEEQQ 227
QL++R Q + Q R ELEQ ++LR S D A + R +EQ
Sbjct: 1183 QLLERWQAVLAQTDVRQRELEQL---------GRQLRYYRESADPLGAWLQDARRRQEQI 1233
Query: 228 RSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCR----------KELEHREAA 277
++ LA A+ REQL Q QAL E+I + C+ K+ E +
Sbjct: 1234 QAMPLADSQAV-REQLRQ----EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288
Query: 278 WRRE-----------------EESFNAYFS--NEHSRLLLLWRQVVGFRRLVSEV--KMF 316
++ + E Y +S L L Q + F +SE +M
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF---ISETLRRME 1345
Query: 317 TERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVL 376
E L + R A EA L L A ++A+A E++A +L+++++++V+
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA---KELQQRMQEEVV 1402
Query: 377 REKDLA---QQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL 433
R ++ A QQQ +S ++ + +E + K + + E+ ++ + E + +
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE-----EEIRVV 1457
Query: 434 RLQEQAALETEDG-EGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRT 492
RLQ +A G EG Q LR A+ E+ Q ++ A+ ++ S ++
Sbjct: 1458 RLQLEATERQRGGAEGELQALRARAE------EAEAQKRQAQEEAERLRRQVQDESQRKR 1511
Query: 493 PSPPRRSSPGRGRSPR-RGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGT 551
+ +S + + R A L L +R Q + R R + L
Sbjct: 1512 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQVALETA 1570
Query: 552 LRKQLSDSESERRALEE---QLQR-LRDKTDGAMQAHEDAQREVQR---LRSANELLSRE 604
R ++ +S+R + E QL+R L+++ Q E+A+R Q+ A E RE
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1630
Query: 605 ------KSNLAHSLQVAQQQAEELRQEREKLQAA----QEELRRQRDRLEEEQEDAVQDG 654
K+N A L++ QAEE+ Q++ QA +EE R+ R + +E AV+
Sbjct: 1631 LERWQLKANEALRLRL---QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687
Query: 655 ARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE 714
+ELE+ + E +R +EL+ +R + QR +L+ E A + A
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747
Query: 715 AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQ------LEEEKSA 768
R ELE + K+RAE L SK A ES + + RL A+ L EE +
Sbjct: 1748 QKRQELEAELAKVRAEMEVLL--ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805
Query: 769 LQG------RQRQ-AEQEATVAREEQERL--EELRLEQEVARQGLEG--SLRVAEQAQEA 817
L+ RQRQ AE++A R E ER+ E+L E R E +L+ E E
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1865
Query: 818 LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR-REAQRQVEALERAAREKEALAK 876
L + +R +L+EQ AQ + R +L +A E +RQ +E R++ + +
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 877 EHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARRE-QLEAEGQ 935
E L A L E R+R E S ++ A+LEA R+ QL AE
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRS-----KEQAELEAARQRQLAAE-- 1978
Query: 936 ALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL 995
+E E Q+ +A +E+A+ ++ +++ + + + + + R + A +E
Sbjct: 1979 -----EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033
Query: 996 QRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLL 1055
++LQ +EAA + L+AE +Q++++EL ++ L +E + L Q R E
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL-------QQTLQQEQSVLDQLRGE---- 2082
Query: 1056 AESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTS 1115
AE+ ++ A +E+ A E R E ER K+ A+ Q Q R+ A
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVE-----EAERLKQSAEE-QAQARAQAQAAAE 2136
Query: 1116 ELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRR 1175
+LR A++E A A A++ Q+QA D ++ + AE+ Q +E LR
Sbjct: 2137 KLRK-EAEQEAARRAQAEQAALRQKQAADAEMEKHK--KFAEQTLRQKAQVEQELTTLRL 2193
Query: 1176 ELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERIS 1235
+L E + E + + EA E R + +E ++R EEL + E+E +
Sbjct: 2194 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2253
Query: 1236 LKLANEDKEQKLALLEEARTA--VGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLD 1293
L L ++D Q+ L EEA V +EA L QE R R A +L + R + +
Sbjct: 2254 LILRDKDNTQRF-LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312
Query: 1294 SENTRLGRELAELQGRLAL----GERAEKESRR--------------ETLGL-------R 1328
E + +E L+ L E A++++RR ET G R
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372
Query: 1329 QRLLKGEASLEVMR---QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHAR 1385
QR L+ A E ++ E+ AQ + +E FR + + L ++++ +
Sbjct: 2373 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432
Query: 1386 GLELKLEAARAEAAELGLRLSAAEGRAQGLEAE-----LARVEVQRRAAEAQLGGLRSAL 1440
LE++ + + +A L ++ E + L+ E L E+Q E L ++
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492
Query: 1441 RRGLGLGRAPSPAPRPVPGSPAR------DAPAEGSGEGLNSPSTLECSPGSQPPSPGPA 1494
+ L + R + A+ D A+ + L + Q A
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK--AQQLREEQQRQQQQMEQERQRLVA 2550
Query: 1495 TSPASPDLDPEAVRGALR--EFLQELRSAQRERDE-LRTQTSALNRQLAEMEAERDSATS 1551
+ + EA G R E LQ+L +R+++E L + L QL +E + +A +
Sbjct: 2551 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2610
Query: 1552 RARQLQKAVAESEEARRSVDGRLSGVQAELALQE--ESVRR---SERERRATLDQVATLE 1606
+ ++ + + + + L G AE + + +RR ++R + A + L+
Sbjct: 2611 HSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2670
Query: 1607 RSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDA-SESRTVKLELQRRSLEGEL 1665
R Q + +++++ + L+G +L A +E +V LQR+ L
Sbjct: 2671 RLAQG-----HTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS--- 2722
Query: 1666 QRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR 1725
+ L L + +A + L D V + +R + VK G + L+ L E + +
Sbjct: 2723 PGTALILLEAQAASGFLLDPVRN-RRLTVNEAVKEGVVG---PELHHKLLSAERAVTGYK 2778
Query: 1726 DKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERL 1770
D G +L Q+ +QK L EH ++L+ ++
Sbjct: 2779 DPYTGQQISLFQA-------------MQKGLIVREHGIRLLEAQI 2810
Score = 220 bits (560), Expect = 1e-56
Identities = 342/1419 (24%), Positives = 607/1419 (42%), Gaps = 206/1419 (14%)
Query: 75 SLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEP 134
+L ++EE +L +Q+ + + LA+ A ++ A ++ QA R E EL+ +
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER-EAKELQQRMQ 1398
Query: 135 RGLVRQ------SVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQR------------- 175
+VR+ + + +R +QEE R+ +A + + RQA+ +R
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 176 ------------LQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLE 223
+G++ + R E E Q + E E+ R + + SQ A + L
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518
Query: 224 EEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTR-CRKELEHREAAWRREE 282
+ A A+ + L++ + +R+ + R + LE + + E
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 283 ESFNAYFSNEHSRL-LLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR--TSRAVQEAG 339
+S A F+ + ++L L + V +L E + ++ Q E AR R ++
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ---QAEAERAREEAERELERWQ 1635
Query: 340 LGLSTGLRLAESRAEAALEKQALLQAQLEEQ-------------LRDKVLREKDLAQQQM 386
L + LRL +AE ++++L QA+ E+Q ++ +R+++LA+Q++
Sbjct: 1636 LKANEALRL-RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1694
Query: 387 QSDLDKADLSARVTELGLAVK----RLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALE 442
+ A+ +A+ LA + RL + + +Q + L E+L RLQ +AA
Sbjct: 1695 EKQRQLAEGTAQQR---LAAEQELIRLRAETEQGEQQRQLLEEELA-----RLQREAAAA 1746
Query: 443 TEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPG 502
T+ + L+ L + +E V L+ R + S S S QR + G
Sbjct: 1747 TQKRQELEAELAKVR------AEMEVLLASKARAEEESR-STSEKSKQRL-----EAEAG 1794
Query: 503 RGRSPRRGPSPACSDSSTL-ALIHSALHKRQLQVQDM-RGRYEASQDLLG---------- 550
R R +++ L AL A +RQL +D R R EA + L
Sbjct: 1795 RFRE-------LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1847
Query: 551 -------TLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANEL-LS 602
L+++ +++E RR E++ + R + A Q D + + +LR A++ L
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1907
Query: 603 REKSNLAHSLQVAQQQAEE---LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
R+K + +L+ +Q EE L+ EK A + EL + R+ ED ++ +
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967
Query: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVE 719
E R RQL E +R A+E V+ A ++ E+ E +A K E R
Sbjct: 1968 EAARQ-RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA--KVEEAR-- 2022
Query: 720 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQE 779
R E + Q+S +L E+ AQ +L Q EE+ A +Q++ E +
Sbjct: 2023 --------RLRERAEQESARQLQLAQEA-AQKRL-------QAEEKAHAFAVQQKEQELQ 2066
Query: 780 ATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ-EALEQQLPTLRHER-SQLQEQLA 837
T+ ++EQ L++LR E E AR+ E + QA+ EA + + ER Q E+ A
Sbjct: 2067 QTL-QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Query: 838 QLSRQLSGREQEL-EQARREAQRQVEALERAAREKEA---------------------LA 875
Q Q ++L ++A +EA R+ +A + A R+K+A +
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 876 KEHAGLAVQLVAAEREGRTLSEEATRLRLE-------KEALEGSLFEVQRQLAQLEARRE 928
+E L +QL + + L EE RL+ E + +E LF V+ Q+ +L +
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 929 QLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQR 988
++EAE +AL+L + T + + + + + AQ+ + + A+ L +QR
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR 2305
Query: 989 AAHEEDL-QRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQ 1047
A E+ L +++Q +EA + EAE Q Q +L +EQ RL+ +KE++++++A Q
Sbjct: 2306 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR---RLQEDKEQMAQQLAEETQ 2362
Query: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDR 1107
L E+E+Q+ L E +A +E+L + +A +S R + DAQ ++Q
Sbjct: 2363 GFQRTL---EAERQRQL-----EMSAEAERL---KLRVAEMSRAQARAEEDAQRFRKQAE 2411
Query: 1108 STVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLE 1167
L R A +E+ E++R Q +AE LR + LE
Sbjct: 2412 EIGEKLH---RTELATQEKVTLVQTLEIQRQQSD------------HDAERLREAIAELE 2456
Query: 1168 DARDGLRRELLEAQRKLRESQEGREVQ-RQEAGELRRS-LGEGAKEREALRRSNEELRSA 1225
++ L++E Q K E Q ++ Q QE L++S L E + R +E
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 1226 VKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQEL 1285
+ + E + E+++++ +E+ R + E R E E + ELQ+L
Sbjct: 2517 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2576
Query: 1286 ----RRQMKMLDSENTRLGR--ELAELQGRLALGE----RAEKESRRETLGLRQRLLKGE 1335
R+Q ++L EN RL +L E Q R AL A + + +TL + L G
Sbjct: 2577 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGP 2636
Query: 1336 ASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEAR 1374
A+ +RK+ Q R +E +L + E R
Sbjct: 2637 AAEAEPEHSFDGLRRKVSAQ----RLQEAGILSAEELQR 2671
Score = 195 bits (496), Expect = 3e-49
Identities = 323/1344 (24%), Positives = 558/1344 (41%), Gaps = 216/1344 (16%)
Query: 746 ESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV------AREEQERL-EELRLEQE 798
E AQ++ R +++L++ + L+ + + + ARE +R+ E+ + + E
Sbjct: 973 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE 1032
Query: 799 VARQGLEGSLRVAEQAQE--ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE 856
V G +G R++ +A++ AL + P RS+L+ L +L + S L E
Sbjct: 1033 VEGLG-KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS-----LSAIYLE 1086
Query: 857 AQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEV 916
+ + + R + E + + H EE + E +A+ +L E+
Sbjct: 1087 KLKTISLVIRGTQGAEEVLRAH------------------EEQLK---EAQAVPATLPEL 1125
Query: 917 QRQLAQLEARREQLEAEGQALLLAKETLTG-ELAGLRQQIIATQEKASLDKELMAQKLVQ 975
+ A L+ R Q EA+ ++ L G + G R Q Q D E+ +
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ----QRHGERDVEVERWR--- 1178
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQ------SQLQREQEEL-- 1027
ER AQ R Q + D++ QRE E R+L R +R QE++
Sbjct: 1179 -ERVAQLLERWQAVLAQTDVR--QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1235
Query: 1028 --LARLEAEKEELSEEIAALQQERDEGLLLAESE---KQQALSLKESEKTALSEKLMGTR 1082
LA +A +E+L +E A L++ G + E + KQ ++K+ E
Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL----------- 1284
Query: 1083 HSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQA 1142
L T ++E A+ + Q S ++ E DLR E +Q ++ + E
Sbjct: 1285 -QLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1341
Query: 1143 RDLGKQRDSCLREAEELRTQLRLLEDARDGLR--------------RELLEAQRKLRESQ 1188
R + ++ ++ E R +L +E A + R RE E Q++++E
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 1189 EGREVQRQEAGELRRSLGEGAKEREALRRSNE-ELRSAVKKAES-ERISLKLANEDKEQK 1246
RE +A + +RS+ E E + LR+S+E E+++ ++AE+ ER L++ E + +
Sbjct: 1402 VRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 1247 LAL--LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELA 1304
L L E R E LR +E E + +A+ E + LRRQ++ E+ R +
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQRKRQAEV 1515
Query: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER 1364
EL R+ +AE E+ RE +QR L+ +LE +R + + A+R+L++ E E R R
Sbjct: 1516 ELASRV----KAEAEAARE----KQRALQ---ALEELRLQAEEAERRLRQAEVE---RAR 1561
Query: 1365 RLLGSLEEARGTEKQQLDHARG--------LELKLEAARAEAAELGLRLSAAEGRAQGLE 1416
++ +LE A+ + + +L R LE L+ A+L R A Q E
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL--REEAERRAQQQAE 1619
Query: 1417 AELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNS 1476
AE AR E +R QL ALR L A A AE E
Sbjct: 1620 AERAREEAERELERWQLKA-NEALRLRL-------QAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 1477 PSTLECSPGSQPPSPGPATSPASPDLDPEA--VRGALREFL---QELRSAQRERDELRTQ 1531
+ G A +L+ + G ++ L QEL + E ++ Q
Sbjct: 1672 EARRR---GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1728
Query: 1532 TSALNRQLAEMEAERDSATSRARQLQKAVAE---------SEEARRSVDGRLSGVQAELA 1582
L +LA ++ E +AT + ++L+ +A+ + +AR + R + +++
Sbjct: 1729 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788
Query: 1583 LQEESVR-RSERERRATLDQVAT-LERSLQATESELRASQEKISKMKANETKLEGDKRRL 1640
L+ E+ R R E A L +A +R Q E + + + ++ A + G+ RL
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1848
Query: 1641 KE----VLDASESRTVKLE-------LQRRSLEGELQRSRLGLSDREAQAQALQDR---- 1685
K L E+ +L QRR LE + + + + +R AQ + D
Sbjct: 1849 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1908
Query: 1686 ----VDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSAS 1741
V+ RQ E + L+ + E+ A++E G +R + Q A
Sbjct: 1909 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ--AE 1966
Query: 1742 LNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADL 1801
L + R + L ++ E R+ +ER+ + A EA +Q + E+V+ L+ +V +
Sbjct: 1967 LEAARQRQLAAEE-----ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 1802 ELQRVEAEG----QLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQL 1857
R AE QLQ +E ++R + E A +Q + + LQ+ L Q L QL
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKA--HAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 1858 EAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELEL 1917
E R+A E+ RV + ERE +S ++
Sbjct: 2080 RGEAEAARRAAEEAEEARV-------QAEREAAQSRR---------------------QV 2111
Query: 1918 AEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARER 1977
EA+R Q E EQ+ + AQ + A++ + E +QE R A+ R +A +
Sbjct: 2112 EEAERLKQSAE------EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD- 2164
Query: 1978 AHRQRVRGLEEQVSTLKGQLQQEL 2001
A ++ + EQ K Q++QEL
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQEL 2188
Score = 188 bits (477), Expect = 5e-47
Identities = 438/1879 (23%), Positives = 754/1879 (40%), Gaps = 272/1879 (14%)
Query: 271 LEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR 330
+ H AA+ EE F + F + +LW Q + F+ + K E D + G
Sbjct: 295 MRHHTAAF--EERRFPSSFEE----IEILWSQFLKFKEMELPAK---EADKNRSKGIYQS 345
Query: 331 TSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLR----EKDLAQQQM 386
AVQ L + G + E A+L+ E+QLR + R ++ + + QM
Sbjct: 346 LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILER--EKQLRSEFERLECLQRIVTKLQM 403
Query: 387 QSDLDKADLSARVTELGLAVKRLEKQNLEK--DQVNKDLTEKLEALESLRLQEQAALETE 444
++ L + L+ L V+ L + + +V +DL +K +++ L +
Sbjct: 404 EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL-DKADSMIRLLFNDV------ 456
Query: 445 DGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRG 504
QTL+D V A + +LR +G +P + +
Sbjct: 457 ------QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG--VAAPATQVAQVTL 508
Query: 505 RSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERR 564
+S +R P + STL + L V++ + R + ++ G + R
Sbjct: 509 QSVQRRPE---LEDSTLRYLQDLL----AWVEENQHRVDGAE--WGVDLPSVEAQLGSHR 559
Query: 565 ALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQ 624
L + ++ R K + A ++ Q + + L R A L ++ + L
Sbjct: 560 GLHQSIEEFRAKIERARS--DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 617
Query: 625 EREKLQAAQEELRRQRDRLEEE-----------QEDAVQDGARVRRELERSHRQLEQLEG 673
+ AA +EL ++ EEE + + + RELE +++++L+
Sbjct: 618 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 677
Query: 674 KRSVLAKELVEVREALS--RATLQRD---MLQAEKAEVAEALTKAEAGRVELELSMTKLR 728
L +E R + +A LQ MLQ EA K A + + +
Sbjct: 678 AGDRLLREDHPARPTVESFQAALQTQWSWMLQL--CCCIEAHLKENAAYFQFFSDVREAE 735
Query: 729 AEEASLQDSLSKLSALNESLAQDKL-----DLNRLVAQLEEEKSALQGRQRQAEQEATVA 783
+ LQ++L + + + S +L D QL E K L G ++A+ A V
Sbjct: 736 GQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK--AVVQ 793
Query: 784 REEQERLEELR----LEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQ-LAQ 838
+ + +R L + +E ++ ++ Q Q + S E +
Sbjct: 794 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 853
Query: 839 LSRQLSGREQELEQARREAQRQVEALERAARE-----KEALAKEHAGLAVQLVAAEREG- 892
+ + QE ++A + Q +AL + K LA + VQL+ +
Sbjct: 854 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT 913
Query: 893 -RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 951
RTL E R L L F Q A ++L AE + G +
Sbjct: 914 FRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREY---------GSCSHH 964
Query: 952 RQQIIATQEKASLDKELMAQKLVQAEREAQASLR--EQRAAHEEDLQRLQRE--KEAAWR 1007
QQ++ + E+ + +E Q+ + ++ + L E R H L L +E +E A R
Sbjct: 965 YQQLLQSLEQGA-QEESRCQRCISELKDIRLQLEACETRTVHRLRLP-LDKEPARECAQR 1022
Query: 1008 ELEAERAQLQ--------SQLQREQEELLARLEAE------KEELSEEIAALQQERDEGL 1053
E ++AQ + ++L E E++LA E + EL + L+Q R
Sbjct: 1023 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1082
Query: 1054 LLAESEKQQALSLK-----ESEKTALSEKLMGTRHSLATISLEMERQK---RDAQSRQEQ 1105
+ E K +L ++ E A E+L + AT+ E+E K + +++ E
Sbjct: 1083 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEA 1141
Query: 1106 DRSTVNALTSELRDLRAQREEAAAAHAQ---EVRRLQEQARDLGK-------QRDSCLRE 1155
+ T +AL ELR + E H + EV R +E+ L + Q D RE
Sbjct: 1142 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRE 1201
Query: 1156 AEELRTQLRLLEDARDGLRRELLEAQRK--------LRESQEGREVQRQEAGELRRSLGE 1207
E+L QLR ++ D L L +A+R+ L +SQ RE RQE L
Sbjct: 1202 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERH 1261
Query: 1208 GAKEREALRRSNEELRSAVKKAESERISLKLANED--KEQKLALLEEARTAVGKEAGELR 1265
G K E R + + + +A+K E + ++ K E K ++ +V +E +LR
Sbjct: 1262 GEKVEECQRFAKQYI-NAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1320
Query: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLG-RELAELQGRLALGERAEKESRRET 1324
T E+ + + + E R+M+ E RL ++ AE + RLA E A ++ R+
Sbjct: 1321 THYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLA 1376
Query: 1325 LGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHA 1384
Q + E + ++Q +Q + +E + + ++R S++E E QQL +
Sbjct: 1377 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR----SIQE----ELQQLRQS 1428
Query: 1385 RGLELKLEAARAEAAELG-LRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRG 1443
E++ +A +AEAAE LR+ E + + +L E QR AE +L LR+
Sbjct: 1429 SEAEIQAKARQAEAAERSRLRI---EEEIRVVRLQLEATERQRGGAEGELQALRARAEE- 1484
Query: 1444 LGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLD 1503
+ A+ A+ E L + SQ + +
Sbjct: 1485 ----------------AEAQKRQAQEEAERLRR----QVQDESQRKRQAEVELASRVKAE 1524
Query: 1504 PEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAES 1563
EA R E + A + +ELR Q R+L + E ER ARQ+Q A+
Sbjct: 1525 AEAAR--------EKQRALQALEELRLQAEEAERRLRQAEVER------ARQVQVAL--- 1567
Query: 1564 EEARRSVDGRLSG---------VQAELALQEESVR----RSERERRATLDQVATLERSLQ 1610
E A+RS + L Q E +LQEE V R E ERRA Q A ER+ +
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA--QQQAEAERARE 1625
Query: 1611 ATESELR-------------------ASQEKISKMKANETKLEGD---KRRLKEVLDASE 1648
E EL A Q+ +++ +A + K E + +RR K A
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1685
Query: 1649 SRTV---KLELQRRSLEG----------ELQRSRLGLSDREAQAQALQDRVDSLQRQVAD 1695
R + +LE QR+ EG EL R R E Q Q L++ + LQR+ A
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745
Query: 1696 SEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE----ALAQSSASLNSTRDKNLH 1751
+ K L+ + ++ + + S+ ++ R +E L + ++
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805
Query: 1752 LQKALTACEHDRQVLQERLDAARQALSEAR---KQSSSLGEQVQTLRGEVADLELQRVEA 1808
L+ + RQ+ +E DAARQ R ++ +++GE + L+ E A++ L+ EA
Sbjct: 1806 LRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATR-LKTE-AEIALKEKEA 1861
Query: 1809 EGQLQQLREVLRQRQEGEAAALNTVQKLQDERRL-LQERLGSLQRAL-AQLEAEKREVE- 1865
E E LR+ E EA +++ + + ++ERL L++A ++LE +K VE
Sbjct: 1862 E------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915
Query: 1866 --RSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQ 1923
R ++E++ +AL+ + +K K + R+ + R+ AELE A QRQ
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQ 1974
Query: 1924 I--QQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQ 1981
+ ++ + E+ E +A +Q+ +EVERL+ A+ E RERA ++
Sbjct: 1975 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK---AKVEEARRLRERAEQE 2031
Query: 1982 RVRGLEEQVSTLKGQLQQE 2000
R L+ + +LQ E
Sbjct: 2032 SARQLQLAQEAAQKRLQAE 2050
Score = 154 bits (389), Expect = 8e-37
Identities = 349/1516 (23%), Positives = 595/1516 (39%), Gaps = 229/1516 (15%)
Query: 550 GTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSA-----NELLSRE 604
G + + L ++S R L +Q L+D G E R V RL E R
Sbjct: 436 GEVERDLDKADSMIRLLFNDVQTLKD---GRHPQGEQMYRRVYRLHERLVAIRTEYNLRL 492
Query: 605 KSNLAH-SLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELER 663
K+ +A + QVAQ + +++ E + L+ +EE Q DGA +L
Sbjct: 493 KAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV--DGAEWGVDLPS 550
Query: 664 SHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ-AEKAEVAEALTKAEAGRVELEL 722
QL G L + + E R + RA L A + + L GR++L+
Sbjct: 551 VEAQL----GSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCL-----GRLDLQY 601
Query: 723 SMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV 782
+ L + +A L+ SL L + + ++ + LN + EEE+ R A
Sbjct: 602 AKL-LNSSKARLR-SLESLHSFVAAATKELMWLN----EKEEEEVGFDWSDRNTNMTA-- 653
Query: 783 AREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 842
++E L E E+ + ++ ++ PT+ ++ LQ Q + + +
Sbjct: 654 ---KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 710
Query: 843 LSGREQELEQAR---------REAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGR 893
E L++ REA+ Q++ L+ A R K + + ++ + + +
Sbjct: 711 CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQ-- 768
Query: 894 TLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQ 953
+E +L K L G L + + + QL+ R G+ LLA +
Sbjct: 769 ---DEKEQLNEYKGHLSG-LAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDY--------K 816
Query: 954 QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013
Q+ T K ++ Q + + + W+ L +
Sbjct: 817 QVEVTVHKG------------------------------DECQLVGPAQPSHWKVLSSSG 846
Query: 1014 AQ--------LQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS 1065
++ L +E +E + RLEA+ + L L + LLA ++ +
Sbjct: 847 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKS--LLAWQSLRRDVQ 904
Query: 1066 LKESEKTALSEKLMGTRHSLATISLEME-----RQKRDAQSRQEQDRSTVNALTSELRDL 1120
L S A L A SLE+ R +DA +DR L
Sbjct: 905 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR------------L 952
Query: 1121 RAQREEAAAAHA-QEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE 1179
A+RE + +H Q++ + EQ + C+ E +++R QL E R R L
Sbjct: 953 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE-TRTVHRLRLPL 1011
Query: 1180 AQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLA 1239
+ RE + R ++Q+A LG+G A L A + R L+L
Sbjct: 1012 DKEPARECAQ-RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT 1070
Query: 1240 NEDKEQKLAL----LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSE 1295
EQ +L LE+ +T G G +EV R+ E +E Q + + L++
Sbjct: 1071 LGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQLKEAQAVPATLPELEAT 1128
Query: 1296 NTRLGRELAELQGRLALGERAEKESR-RETLGLRQRLLKGEASLEVMRQELQVAQRKLQE 1354
L + A+ + + + E R + +G R + GE +EV R +VAQ +
Sbjct: 1129 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1188
Query: 1355 QEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQG 1414
Q +T + R E +QL +L R A LG L A R +
Sbjct: 1189 QAVLAQT----------DVRQRELEQLGR------QLRYYRESADPLGAWLQDARRRQEQ 1232
Query: 1415 LEA-ELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEG 1473
++A LA + R + L R G + A + + +A + +
Sbjct: 1233 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI------NAIKDYELQL 1286
Query: 1474 LNSPSTLE--CSPGSQPPSPGPATSPASPDLDPEAVRGALR-------EFLQELRSAQRE 1524
+ + LE SP +P + S +D L +F+ E E
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1346
Query: 1525 RDELRTQTSALNRQ-LAEMEAERDSATSRARQLQKAVAESE-EARRSVDGRLSGVQAELA 1582
+ L Q A R+ LAE+EA A + RQL +A A+++ +A R +Q E+
Sbjct: 1347 EERLAEQQRAEERERLAEVEA----ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 1583 LQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKE 1642
+EE+ +++++R+ +++ L Q++E+E++A + + + ++E + R ++
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459
Query: 1643 VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGT 1702
L+A+E QR EGELQ R + EAQ + Q+ + L+RQV D +
Sbjct: 1460 QLEATER-------QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK-- 1510
Query: 1703 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKA-----LT 1757
++E L +V+ EA + +L + + L ++A
Sbjct: 1511 ---------------RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1555
Query: 1758 ACEHDRQVLQERLDAARQALSEARKQSSSLGEQV----QTLRGEVADLELQRVEAEGQLQ 1813
E RQV A R A +E + + +S E+ ++L+ E + R EAE + Q
Sbjct: 1556 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 1814 QLREVLRQRQEGEAAALNTVQKLQDERRL-LQERLGSLQRALAQLEAEKREVERSALRLE 1872
Q E R R+E E K + RL LQ + Q++LAQ EAEK++ E
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA------ 1669
Query: 1873 KDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV- 1931
+R A RR K E + +R E AE EL E QRQ+ + AQ
Sbjct: 1670 -EREARRR--GKAEEQAVRQREL-----------------AEQEL-EKQRQLAEGTAQQR 1708
Query: 1932 VVLEQSHSPAQLEVDAQQQQLE-LQQEVERL-RSAQAQTERTLEARERAHRQRVRGLEEQ 1989
+ EQ + E + +QQ + L++E+ RL R A A T++ E A +VR E
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL--EAELAKVRAEMEV 1766
Query: 1990 VSTLKGQLQQELRRSS 2005
+ K + ++E R +S
Sbjct: 1767 LLASKARAEEESRSTS 1782
Score = 48.9 bits (115), Expect = 5e-05
Identities = 48/216 (22%), Positives = 98/216 (45%), Gaps = 17/216 (7%)
Query: 5 LARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPES 64
LA ++V L IQ +S + +L ++ + A + ++ + + +
Sbjct: 2422 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2481
Query: 65 PVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRL 124
LL T+ L E++ LLQ+ E + Q +A+ ++L A +++L + +
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQR-----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536
Query: 125 EPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYK 184
+ ++E QE + LV E RR+ E + RRK + Q+ +Q++ Q + L
Sbjct: 2537 QQQQME-QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL-------- 2587
Query: 185 KRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI 220
+E Q+L E+ LE+Q HS+++ ++ +
Sbjct: 2588 ---AEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2620
Score = 35.4 bits (80), Expect = 0.57
Identities = 89/418 (21%), Positives = 174/418 (41%), Gaps = 43/418 (10%)
Query: 1606 ERSLQATESELRASQEKISKMKANETKL-EGDKRRLKEVLDASESRTVKLELQ------R 1658
ER ++ E+ + K K E E DK R K + + E +L+
Sbjct: 304 ERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP 363
Query: 1659 RSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVE 1718
+E E + + + +RE Q ++ +R++ LQR V +++AG L E+LN
Sbjct: 364 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG---LCEEQLN------- 413
Query: 1719 ESEGALRDKVRGLTEA-LAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQAL 1777
+++ L+ VR L + Q + + DK + + L +D Q L+ D
Sbjct: 414 QADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF---NDVQTLK---DGRHPQG 467
Query: 1778 SEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQ 1837
+ ++ L E++ +R E +L L+ A Q + L+ Q +T++ LQ
Sbjct: 468 EQMYRRVYRLHERLVAIRTEY-NLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ 526
Query: 1838 DERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV 1897
D ++E + A ++ E + + R L +++++ + R+ D
Sbjct: 527 DLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR------GLHQSIEEFRAKIERARSDEG 580
Query: 1898 RLS-AEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL-Q 1955
+LS A +G L +L+ A + + +A++ LE HS A ++ + L +
Sbjct: 581 QLSPATRGAYRDCLGRLDLQYA---KLLNSSKARLRSLESLHS---FVAAATKELMWLNE 634
Query: 1956 QEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQ---QELRRSSAPFSP 2010
+E E + + + A++ ++ +R LE + +K +LQ L R P P
Sbjct: 635 KEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK-ELQNAGDRLLREDHPARP 691
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 266 bits (680), Expect = 2e-70
Identities = 459/1955 (23%), Positives = 813/1955 (41%), Gaps = 297/1955 (15%)
Query: 110 KYNAVSERLEQALR-LEPGELETQEPRGLVRQSVELRRQLQ--EEQASYRRKL------- 159
+Y + S +Q L+ LE G E + + + ++R QL+ E + +R +L
Sbjct: 961 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA 1020
Query: 160 ----QAYQEGQQRQAQL------VQRLQG---KILQYKK---RCSELEQQLLERSGELEQ 203
Q E Q+ QA++ V RL K+L + L +L G+LEQ
Sbjct: 1021 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1080
Query: 204 QR----------------LRDTEHSQD-LESALIRLEEEQQRSASLAQVNAM------LR 240
R +R T+ +++ L + +L+E Q A+L ++ A LR
Sbjct: 1081 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1140
Query: 241 EQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLW 300
Q + AL +++R R ++ R+ R E ++LL W
Sbjct: 1141 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERV--------AQLLERW 1192
Query: 301 RQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAES-RAEAALEK 359
+ V+ ++V+ +R+L QLG +L + G L R E +A +
Sbjct: 1193 QAVLA----QTDVR---QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1245
Query: 360 QALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQV 419
QA+ + +EQ + + ++ Q + + + EL L + + + +
Sbjct: 1246 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK 1305
Query: 420 NKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADA 479
+ E++ +QE L T E T +Q + SE+ ++ ER A+
Sbjct: 1306 KPKVQSGSESV----IQEYVDLRTHYSELTTLT----SQYIKFISETLRRMEEEERLAEQ 1357
Query: 480 SNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMR 539
QR R + +R + A + + A + ++++Q + +R
Sbjct: 1358 ----------QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407
Query: 540 GRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANE 599
R EA+ D ++ ++R+++E+LQ+LR ++ +QA + R A E
Sbjct: 1408 -REEAAVD-----------AQQQKRSIQEELQQLRQSSEAEIQA---------KARQA-E 1445
Query: 600 LLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
R + + ++V + Q E ++R + + LR + + E ++ A ++ R+RR
Sbjct: 1446 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1505
Query: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRA--TLQRDMLQAEKAEVAEALTKAEAGR 717
+++ ++ Q E + + K E RA L+ LQAE+AE + E R
Sbjct: 1506 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1565
Query: 718 VELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAE 777
T R+ EA LQ + + L + + + VAQL EE R+ Q +
Sbjct: 1566 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE----RRAQQQ 1621
Query: 778 QEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLA 837
EA AREE ER EL Q A + L L+ E AQ Q+ LA
Sbjct: 1622 AEAERAREEAER--ELERWQLKANEALRLRLQAEEVAQ-----------------QKSLA 1662
Query: 838 QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKE-------HAGLAVQLVAAER 890
Q E++ E+A REA+R+ +A E+A R++E +E G A Q +AAE+
Sbjct: 1663 QAEA-----EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1717
Query: 891 EGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAG 950
E L E + +++ LE L +QR+ A +R++LEAE + E L A
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1777
Query: 951 LRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELE 1010
++ +T EK+ E A + + EA R + A E QR E++AA + E
Sbjct: 1778 AEEESRSTSEKSKQRLEAEAGRFRELAEEAA---RLRALAEEAKRQRQLAEEDAARQRAE 1834
Query: 1011 AERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLL--LAESEKQQALSLKE 1068
AER E+L A EA + + EIA ++E + L LAE E Q L+E
Sbjct: 1835 AERVLA--------EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1886
Query: 1069 S---EKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQRE 1125
K + E+L R + + E+ERQK + Q R + E+ L+A E
Sbjct: 1887 QAAQHKADIEERLAQLRKASDS---ELERQKGLVEDTLRQRRQ----VEEEILALKASFE 1939
Query: 1126 EAAAAHAQ---EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
+AAA A+ E+ R++ A D + ++ EA R QL E+ R RRE E +
Sbjct: 1940 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-QLAAEEERR---RREAEERVQ 1995
Query: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERI-SLKLANE 1241
K ++E QR+ A E E E L+ EE R ++AE E L+LA E
Sbjct: 1996 KSLAAEEEAARQRKAALE----------EVERLKAKVEEARRLRERAEQESARQLQLAQE 2045
Query: 1242 DKEQKLALLEEART-AVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLG 1300
+++L E+A AV ++ EL+ LQ+ + + R E + RR + + +
Sbjct: 2046 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2105
Query: 1301 RELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQEL-QVAQRKLQEQEGEF 1359
RE A+ + ++ ER ++ + + Q + +A+ E +R+E Q A R+ Q ++
Sbjct: 2106 REAAQSRRQVEEAERLKQSAEEQA----QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2161
Query: 1360 RTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAEL 1419
R ++ +E+ + +Q L +E +L R L+L + + L+ EL
Sbjct: 2162 RQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR-------LQLEETDHQKNLLDEEL 2213
Query: 1420 ARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPST 1479
R++ + A Q RS + L R
Sbjct: 2214 QRLKAEATEAARQ----RSQVEEELFSVR------------------------------- 2238
Query: 1480 LECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRE--RDELRTQTSALNR 1537
++ S+ + A + A D + + L+E ++++ E R + Q +A R
Sbjct: 2239 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2298
Query: 1538 QLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRA 1597
QLAE + + A + +K A E R + L Q ELA +E RR + ++
Sbjct: 2299 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA--QEQARRLQEDKEQ 2356
Query: 1598 TLDQVATLERSLQAT-------ESELRASQEK----ISKMKANETKLEGDKRRLKEVLDA 1646
Q+A + Q T + E+ A E+ +++M + + E D +R ++ +
Sbjct: 2357 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2416
Query: 1647 SESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLT 1706
+ + EL + +Q + + A+ L++ + L+R+ + +A LQL
Sbjct: 2417 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL- 2475
Query: 1707 VERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNST---RDKNLHLQKALTACEHDR 1763
K EE + ++++ T+AL QS S + R++ + +KA
Sbjct: 2476 ---------KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL-----E 2521
Query: 1764 QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQ 1823
Q+ Q+ + A+Q E ++Q + ++ Q L VA +E EA + + E +R++Q
Sbjct: 2522 QLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASME----EARRRQHEAEEGVRRKQ 2574
Query: 1824 EGEAAALNTVQKLQDERR----LLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALR 1879
E +Q+L+ +RR LL E L+ L LE + R + + +VA
Sbjct: 2575 E-------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2627
Query: 1880 RTLDK---------VEREKLRSHEDTVR-LSAEKGRLDRTLTGAELE-LAEAQRQIQQLE 1928
+TL E E S + R +SA++ + L+ EL+ LA+ + +L
Sbjct: 2628 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2687
Query: 1929 AQVVV---LEQSHSPAQLEVDAQQQQLELQQEVER 1960
+ V L+ S A L + A ++L + ++R
Sbjct: 2688 RREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQR 2722
Score = 263 bits (673), Expect = 1e-69
Identities = 357/1544 (23%), Positives = 644/1544 (41%), Gaps = 172/1544 (11%)
Query: 543 EASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRS-ANELL 601
EA++ L LR Q + AL ++L+ ++ + Q H + EV+R R +LL
Sbjct: 1130 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1189
Query: 602 SREKSNLAHSLQVAQQQAEEL----RQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARV 657
R ++ LA + V Q++ E+L R RE L+ R R E+ Q + D V
Sbjct: 1190 ERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1248
Query: 658 RRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGR 717
R +L + LE++E EK E + K
Sbjct: 1249 REQLRQEQALLEEIER--------------------------HGEKVEECQRFAKQYINA 1282
Query: 718 V---ELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQL-----------E 763
+ EL+L K + E + K+ + +ES+ Q+ +DL ++L
Sbjct: 1283 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1342
Query: 764 EEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLP 823
E ++ +R AEQ+ EE+ERL E+ E RQ E + QA+ ++
Sbjct: 1343 ETLRRMEEEERLAEQQRA---EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1399
Query: 824 TLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEA----LERAAREKEALAKEHA 879
++ E + +E +Q ++EL+Q R+ ++ +++A E A R + + +E
Sbjct: 1400 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1459
Query: 880 GLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEAR---REQLEAEGQA 936
+ +QL A ER+ E LR E E + Q + +L + Q + + +
Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1519
Query: 937 LLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAE---------------REAQ 981
L ++ E A +Q+ + E+ L E ++L QAE R A+
Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579
Query: 982 ASLREQRAAHEEDLQRLQREKE------AAWRELEAERAQLQSQLQREQEELLARLEA-- 1033
A L+ +RA+ E +L+R + A RE RAQ Q++ +R +EE LE
Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1639
Query: 1034 --EKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE 1091
E L + A + + + L AE+EKQ+ + +E+ + +E+ + LA LE
Sbjct: 1640 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1699
Query: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHA---QEVRRLQEQARDLGKQ 1148
+RQ + ++Q A EL LRA+ E+ +E+ RLQ +A ++
Sbjct: 1700 KQRQLAEGTAQQRL------AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1753
Query: 1149 RDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLR---ESQEGREVQRQEAGELRRSL 1205
R E ++R ++ +L ++ E K + E++ GR + E R+L
Sbjct: 1754 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1813
Query: 1206 GEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELR 1265
E AK + L + +A ++AE+ER+ +KLA + EA K E+
Sbjct: 1814 AEEAKRQRQLAEED----AARQRAEAERVLA--------EKLAAIGEATRL--KTEAEIA 1859
Query: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETL 1325
+E E RL RR ++ Q + L+ + + A+++ RLA +A
Sbjct: 1860 LKEKEAENERL--RRLAEDEAFQRRRLEEQ---AAQHKADIEERLAQLRKASDSELERQK 1914
Query: 1326 GLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA-RGTEKQQLDHA 1384
GL + L+ +E L+ + K + E R+ + E+ R E+ +L+ A
Sbjct: 1915 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1974
Query: 1385 RGLELKLEAARA--EAAE-LGLRLSAAEGRAQGLEAELARVE-VQRRAAEAQLGGLRSAL 1440
R +L E R EA E + L+A E A+ +A L VE ++ + EA+ R+
Sbjct: 1975 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2034
Query: 1441 RRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASP 1500
L A A + + A A E TL+ G A
Sbjct: 2035 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ-ELQQTLQQEQSVLDQLRGEA------ 2087
Query: 1501 DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNR--QLAEMEAERDSATSRARQLQK 1558
EA R A E + A+RE + R Q R Q AE +A+ + A + +
Sbjct: 2088 ----EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2143
Query: 1559 AVAESEEARRSVDGRLS-----GVQAELALQEESVRRSERERRATLDQVATLERSLQATE 1613
AE E ARR+ + + AE+ ++ ++ R++ ++ TL L+ T+
Sbjct: 2144 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2203
Query: 1614 SELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLS 1673
+ E++ ++KA T+ + +++E L + + +L + +E E L L
Sbjct: 2204 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE--NRALILR 2261
Query: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGA----LAKVEE-SEGALRDKV 1728
D++ + LQ+ + + +QVA+ + RL LA+ +E L++K+
Sbjct: 2262 DKDNTQRFLQEEAEKM-KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2320
Query: 1729 RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQ---ERLDAARQALSEARKQSS 1785
+ + EA + + + K L ++A E Q+ Q E ++ L R++
Sbjct: 2321 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2380
Query: 1786 SLGEQVQTLRGEVADLELQRVEAEGQLQQLR-------EVLRQRQEGEAAALNTVQKLQD 1838
+ + + L+ VA++ + AE Q+ R E L + + + VQ L+
Sbjct: 2381 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2440
Query: 1839 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR 1898
+R+ L+ A+A+LE EK ++++ A L+ + V++E+L
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQ------ 2490
Query: 1899 LSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV 1958
E L ++ + L + +R I+Q +A++ L Q ++ +QQ+ + Q E
Sbjct: 2491 ---ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547
Query: 1959 ERLRSAQAQTERTLEARERAH--RQRVRGLEEQVSTLKGQLQQE 2000
ER R + EAR R H + VR +E++ L+ Q +Q+
Sbjct: 2548 ERQRLVASME----EARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2587
Score = 234 bits (597), Expect = 6e-61
Identities = 425/1785 (23%), Positives = 742/1785 (41%), Gaps = 230/1785 (12%)
Query: 116 ERLEQALRLEPGELETQEP-----RGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQA 170
E + +L+ + E Q+P R +R + E+ +LQ+ +++ ++E R A
Sbjct: 1130 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE---RVA 1186
Query: 171 QLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI---RLEEEQQ 227
QL++R Q + Q R ELEQ ++LR S D A + R +EQ
Sbjct: 1187 QLLERWQAVLAQTDVRQRELEQL---------GRQLRYYRESADPLGAWLQDARRRQEQI 1237
Query: 228 RSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCR----------KELEHREAA 277
++ LA A+ REQL Q QAL E+I + C+ K+ E +
Sbjct: 1238 QAMPLADSQAV-REQLRQ----EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1292
Query: 278 WRRE-----------------EESFNAYFS--NEHSRLLLLWRQVVGFRRLVSEV--KMF 316
++ + E Y +S L L Q + F +SE +M
Sbjct: 1293 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF---ISETLRRME 1349
Query: 317 TERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVL 376
E L + R A EA L L A ++A+A E++A +L+++++++V+
Sbjct: 1350 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA---KELQQRMQEEVV 1406
Query: 377 REKDLA---QQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL 433
R ++ A QQQ +S ++ + +E + K + + E+ ++ + E + +
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE-----EEIRVV 1461
Query: 434 RLQEQAALETEDG-EGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRT 492
RLQ +A G EG Q LR A+ E+ Q ++ A+ ++ S ++
Sbjct: 1462 RLQLEATERQRGGAEGELQALRARAE------EAEAQKRQAQEEAERLRRQVQDESQRKR 1515
Query: 493 PSPPRRSSPGRGRSPR-RGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGT 551
+ +S + + R A L L +R Q + R R + L
Sbjct: 1516 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQVALETA 1574
Query: 552 LRKQLSDSESERRALEE---QLQR-LRDKTDGAMQAHEDAQREVQR---LRSANELLSRE 604
R ++ +S+R + E QL+R L+++ Q E+A+R Q+ A E RE
Sbjct: 1575 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1634
Query: 605 ------KSNLAHSLQVAQQQAEELRQEREKLQAA----QEELRRQRDRLEEEQEDAVQDG 654
K+N A L++ QAEE+ Q++ QA +EE R+ R + +E AV+
Sbjct: 1635 LERWQLKANEALRLRL---QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1691
Query: 655 ARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE 714
+ELE+ + E +R +EL+ +R + QR +L+ E A + A
Sbjct: 1692 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1751
Query: 715 AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQ------LEEEKSA 768
R ELE + K+RAE L SK A ES + + RL A+ L EE +
Sbjct: 1752 QKRQELEAELAKVRAEMEVLL--ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1809
Query: 769 LQG------RQRQ-AEQEATVAREEQERL--EELRLEQEVARQGLEG--SLRVAEQAQEA 817
L+ RQRQ AE++A R E ER+ E+L E R E +L+ E E
Sbjct: 1810 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1869
Query: 818 LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR-REAQRQVEALERAAREKEALAK 876
L + +R +L+EQ AQ + R +L +A E +RQ +E R++ + +
Sbjct: 1870 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1929
Query: 877 EHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARRE-QLEAEGQ 935
E L A L E R+R E S ++ A+LEA R+ QL AE
Sbjct: 1930 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRS-----KEQAELEAARQRQLAAE-- 1982
Query: 936 ALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL 995
+E E Q+ +A +E+A+ ++ +++ + + + + + R + A +E
Sbjct: 1983 -----EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2037
Query: 996 QRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLL 1055
++LQ +EAA + L+AE +Q++++EL ++ L +E + L Q R E
Sbjct: 2038 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL-------QQTLQQEQSVLDQLRGE---- 2086
Query: 1056 AESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTS 1115
AE+ ++ A +E+ A E R E ER K+ A+ Q Q R+ A
Sbjct: 2087 AEAARRAAEEAEEARVQAEREAAQSRRQVE-----EAERLKQSAEE-QAQARAQAQAAAE 2140
Query: 1116 ELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRR 1175
+LR A++E A A A++ Q+QA D ++ + AE+ Q +E LR
Sbjct: 2141 KLRK-EAEQEAARRAQAEQAALRQKQAADAEMEKHK--KFAEQTLRQKAQVEQELTTLRL 2197
Query: 1176 ELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERIS 1235
+L E + E + + EA E R + +E ++R EEL + E+E +
Sbjct: 2198 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2257
Query: 1236 LKLANEDKEQKLALLEEARTA--VGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLD 1293
L L ++D Q+ L EEA V +EA L QE R R A +L + R + +
Sbjct: 2258 LILRDKDNTQRF-LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2316
Query: 1294 SENTRLGRELAELQGRLAL----GERAEKESRR--------------ETLGL-------R 1328
E + +E L+ L E A++++RR ET G R
Sbjct: 2317 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2376
Query: 1329 QRLLKGEASLEVMR---QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHAR 1385
QR L+ A E ++ E+ AQ + +E FR + + L ++++ +
Sbjct: 2377 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2436
Query: 1386 GLELKLEAARAEAAELGLRLSAAEGRAQGLEAE-----LARVEVQRRAAEAQLGGLRSAL 1440
LE++ + + +A L ++ E + L+ E L E+Q E L ++
Sbjct: 2437 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2496
Query: 1441 RRGLGLGRAPSPAPRPVPGSPAR------DAPAEGSGEGLNSPSTLECSPGSQPPSPGPA 1494
+ L + R + A+ D A+ + L + Q A
Sbjct: 2497 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK--AQQLREEQQRQQQQMEQERQRLVA 2554
Query: 1495 TSPASPDLDPEAVRGALR--EFLQELRSAQRERDE-LRTQTSALNRQLAEMEAERDSATS 1551
+ + EA G R E LQ+L +R+++E L + L QL +E + +A +
Sbjct: 2555 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2614
Query: 1552 RARQLQKAVAESEEARRSVDGRLSGVQAELALQE--ESVRR---SERERRATLDQVATLE 1606
+ ++ + + + + L G AE + + +RR ++R + A + L+
Sbjct: 2615 HSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2674
Query: 1607 RSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDA-SESRTVKLELQRRSLEGEL 1665
R Q + +++++ + L+G +L A +E +V LQR+ L
Sbjct: 2675 RLAQG-----HTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS--- 2726
Query: 1666 QRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR 1725
+ L L + +A + L D V + +R + VK G + L+ L E + +
Sbjct: 2727 PGTALILLEAQAASGFLLDPVRN-RRLTVNEAVKEGVVG---PELHHKLLSAERAVTGYK 2782
Query: 1726 DKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERL 1770
D G +L Q+ +QK L EH ++L+ ++
Sbjct: 2783 DPYTGQQISLFQA-------------MQKGLIVREHGIRLLEAQI 2814
Score = 220 bits (560), Expect = 1e-56
Identities = 342/1419 (24%), Positives = 607/1419 (42%), Gaps = 206/1419 (14%)
Query: 75 SLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEP 134
+L ++EE +L +Q+ + + LA+ A ++ A ++ QA R E EL+ +
Sbjct: 1344 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER-EAKELQQRMQ 1402
Query: 135 RGLVRQ------SVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQR------------- 175
+VR+ + + +R +QEE R+ +A + + RQA+ +R
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1462
Query: 176 ------------LQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLE 223
+G++ + R E E Q + E E+ R + + SQ A + L
Sbjct: 1463 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1522
Query: 224 EEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTR-CRKELEHREAAWRREE 282
+ A A+ + L++ + +R+ + R + LE + + E
Sbjct: 1523 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1582
Query: 283 ESFNAYFSNEHSRL-LLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR--TSRAVQEAG 339
+S A F+ + ++L L + V +L E + ++ Q E AR R ++
Sbjct: 1583 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ---QAEAERAREEAERELERWQ 1639
Query: 340 LGLSTGLRLAESRAEAALEKQALLQAQLEEQ-------------LRDKVLREKDLAQQQM 386
L + LRL +AE ++++L QA+ E+Q ++ +R+++LA+Q++
Sbjct: 1640 LKANEALRL-RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1698
Query: 387 QSDLDKADLSARVTELGLAVK----RLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALE 442
+ A+ +A+ LA + RL + + +Q + L E+L RLQ +AA
Sbjct: 1699 EKQRQLAEGTAQQR---LAAEQELIRLRAETEQGEQQRQLLEEELA-----RLQREAAAA 1750
Query: 443 TEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPG 502
T+ + L+ L + +E V L+ R + S S S QR + G
Sbjct: 1751 TQKRQELEAELAKVR------AEMEVLLASKARAEEESR-STSEKSKQRL-----EAEAG 1798
Query: 503 RGRSPRRGPSPACSDSSTL-ALIHSALHKRQLQVQDM-RGRYEASQDLLG---------- 550
R R +++ L AL A +RQL +D R R EA + L
Sbjct: 1799 RFRE-------LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1851
Query: 551 -------TLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANEL-LS 602
L+++ +++E RR E++ + R + A Q D + + +LR A++ L
Sbjct: 1852 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1911
Query: 603 REKSNLAHSLQVAQQQAEE---LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
R+K + +L+ +Q EE L+ EK A + EL + R+ ED ++ +
Sbjct: 1912 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1971
Query: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVE 719
E R RQL E +R A+E V+ A ++ E+ E +A K E R
Sbjct: 1972 EAARQ-RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA--KVEEAR-- 2026
Query: 720 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQE 779
R E + Q+S +L E+ AQ +L Q EE+ A +Q++ E +
Sbjct: 2027 --------RLRERAEQESARQLQLAQEA-AQKRL-------QAEEKAHAFAVQQKEQELQ 2070
Query: 780 ATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ-EALEQQLPTLRHER-SQLQEQLA 837
T+ ++EQ L++LR E E AR+ E + QA+ EA + + ER Q E+ A
Sbjct: 2071 QTL-QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2129
Query: 838 QLSRQLSGREQEL-EQARREAQRQVEALERAAREKEA---------------------LA 875
Q Q ++L ++A +EA R+ +A + A R+K+A +
Sbjct: 2130 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2189
Query: 876 KEHAGLAVQLVAAEREGRTLSEEATRLRLE-------KEALEGSLFEVQRQLAQLEARRE 928
+E L +QL + + L EE RL+ E + +E LF V+ Q+ +L +
Sbjct: 2190 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2249
Query: 929 QLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQR 988
++EAE +AL+L + T + + + + + AQ+ + + A+ L +QR
Sbjct: 2250 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR 2309
Query: 989 AAHEEDL-QRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQ 1047
A E+ L +++Q +EA + EAE Q Q +L +EQ RL+ +KE++++++A Q
Sbjct: 2310 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR---RLQEDKEQMAQQLAEETQ 2366
Query: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDR 1107
L E+E+Q+ L E +A +E+L + +A +S R + DAQ ++Q
Sbjct: 2367 GFQRTL---EAERQRQL-----EMSAEAERL---KLRVAEMSRAQARAEEDAQRFRKQAE 2415
Query: 1108 STVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLE 1167
L R A +E+ E++R Q +AE LR + LE
Sbjct: 2416 EIGEKLH---RTELATQEKVTLVQTLEIQRQQSD------------HDAERLREAIAELE 2460
Query: 1168 DARDGLRRELLEAQRKLRESQEGREVQ-RQEAGELRRS-LGEGAKEREALRRSNEELRSA 1225
++ L++E Q K E Q ++ Q QE L++S L E + R +E
Sbjct: 2461 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2520
Query: 1226 VKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQEL 1285
+ + E + E+++++ +E+ R + E R E E + ELQ+L
Sbjct: 2521 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2580
Query: 1286 ----RRQMKMLDSENTRLGR--ELAELQGRLALGE----RAEKESRRETLGLRQRLLKGE 1335
R+Q ++L EN RL +L E Q R AL A + + +TL + L G
Sbjct: 2581 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGP 2640
Query: 1336 ASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEAR 1374
A+ +RK+ Q R +E +L + E R
Sbjct: 2641 AAEAEPEHSFDGLRRKVSAQ----RLQEAGILSAEELQR 2675
Score = 195 bits (496), Expect = 3e-49
Identities = 323/1344 (24%), Positives = 558/1344 (41%), Gaps = 216/1344 (16%)
Query: 746 ESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV------AREEQERL-EELRLEQE 798
E AQ++ R +++L++ + L+ + + + ARE +R+ E+ + + E
Sbjct: 977 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE 1036
Query: 799 VARQGLEGSLRVAEQAQE--ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE 856
V G +G R++ +A++ AL + P RS+L+ L +L + S L E
Sbjct: 1037 VEGLG-KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS-----LSAIYLE 1090
Query: 857 AQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEV 916
+ + + R + E + + H EE + E +A+ +L E+
Sbjct: 1091 KLKTISLVIRGTQGAEEVLRAH------------------EEQLK---EAQAVPATLPEL 1129
Query: 917 QRQLAQLEARREQLEAEGQALLLAKETLTG-ELAGLRQQIIATQEKASLDKELMAQKLVQ 975
+ A L+ R Q EA+ ++ L G + G R Q Q D E+ +
Sbjct: 1130 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ----QRHGERDVEVERWR--- 1182
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQ------SQLQREQEEL-- 1027
ER AQ R Q + D++ QRE E R+L R +R QE++
Sbjct: 1183 -ERVAQLLERWQAVLAQTDVR--QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1239
Query: 1028 --LARLEAEKEELSEEIAALQQERDEGLLLAESE---KQQALSLKESEKTALSEKLMGTR 1082
LA +A +E+L +E A L++ G + E + KQ ++K+ E
Sbjct: 1240 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL----------- 1288
Query: 1083 HSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQA 1142
L T ++E A+ + Q S ++ E DLR E +Q ++ + E
Sbjct: 1289 -QLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1345
Query: 1143 RDLGKQRDSCLREAEELRTQLRLLEDARDGLR--------------RELLEAQRKLRESQ 1188
R + ++ ++ E R +L +E A + R RE E Q++++E
Sbjct: 1346 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1405
Query: 1189 EGREVQRQEAGELRRSLGEGAKEREALRRSNE-ELRSAVKKAES-ERISLKLANEDKEQK 1246
RE +A + +RS+ E E + LR+S+E E+++ ++AE+ ER L++ E + +
Sbjct: 1406 VRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1462
Query: 1247 LAL--LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELA 1304
L L E R E LR +E E + +A+ E + LRRQ++ E+ R +
Sbjct: 1463 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQRKRQAEV 1519
Query: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER 1364
EL R+ +AE E+ RE +QR L+ +LE +R + + A+R+L++ E E R R
Sbjct: 1520 ELASRV----KAEAEAARE----KQRALQ---ALEELRLQAEEAERRLRQAEVE---RAR 1565
Query: 1365 RLLGSLEEARGTEKQQLDHARG--------LELKLEAARAEAAELGLRLSAAEGRAQGLE 1416
++ +LE A+ + + +L R LE L+ A+L R A Q E
Sbjct: 1566 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL--REEAERRAQQQAE 1623
Query: 1417 AELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNS 1476
AE AR E +R QL ALR L A A AE E
Sbjct: 1624 AERAREEAERELERWQLKA-NEALRLRL-------QAEEVAQQKSLAQAEAEKQKEEAER 1675
Query: 1477 PSTLECSPGSQPPSPGPATSPASPDLDPEA--VRGALREFL---QELRSAQRERDELRTQ 1531
+ G A +L+ + G ++ L QEL + E ++ Q
Sbjct: 1676 EARRR---GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1732
Query: 1532 TSALNRQLAEMEAERDSATSRARQLQKAVAE---------SEEARRSVDGRLSGVQAELA 1582
L +LA ++ E +AT + ++L+ +A+ + +AR + R + +++
Sbjct: 1733 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1792
Query: 1583 LQEESVR-RSERERRATLDQVAT-LERSLQATESELRASQEKISKMKANETKLEGDKRRL 1640
L+ E+ R R E A L +A +R Q E + + + ++ A + G+ RL
Sbjct: 1793 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1852
Query: 1641 KE----VLDASESRTVKLE-------LQRRSLEGELQRSRLGLSDREAQAQALQDR---- 1685
K L E+ +L QRR LE + + + + +R AQ + D
Sbjct: 1853 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1912
Query: 1686 ----VDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSAS 1741
V+ RQ E + L+ + E+ A++E G +R + Q A
Sbjct: 1913 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ--AE 1970
Query: 1742 LNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADL 1801
L + R + L ++ E R+ +ER+ + A EA +Q + E+V+ L+ +V +
Sbjct: 1971 LEAARQRQLAAEE-----ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2025
Query: 1802 ELQRVEAEG----QLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQL 1857
R AE QLQ +E ++R + E A +Q + + LQ+ L Q L QL
Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQKRLQAEEKA--HAFAVQQKEQELQQTLQQEQSVLDQL 2083
Query: 1858 EAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELEL 1917
E R+A E+ RV + ERE +S ++
Sbjct: 2084 RGEAEAARRAAEEAEEARV-------QAEREAAQSRR---------------------QV 2115
Query: 1918 AEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARER 1977
EA+R Q E EQ+ + AQ + A++ + E +QE R A+ R +A +
Sbjct: 2116 EEAERLKQSAE------EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD- 2168
Query: 1978 AHRQRVRGLEEQVSTLKGQLQQEL 2001
A ++ + EQ K Q++QEL
Sbjct: 2169 AEMEKHKKFAEQTLRQKAQVEQEL 2192
Score = 188 bits (477), Expect = 5e-47
Identities = 438/1879 (23%), Positives = 754/1879 (40%), Gaps = 272/1879 (14%)
Query: 271 LEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR 330
+ H AA+ EE F + F + +LW Q + F+ + K E D + G
Sbjct: 299 MRHHTAAF--EERRFPSSFEE----IEILWSQFLKFKEMELPAK---EADKNRSKGIYQS 349
Query: 331 TSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLR----EKDLAQQQM 386
AVQ L + G + E A+L+ E+QLR + R ++ + + QM
Sbjct: 350 LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILER--EKQLRSEFERLECLQRIVTKLQM 407
Query: 387 QSDLDKADLSARVTELGLAVKRLEKQNLEK--DQVNKDLTEKLEALESLRLQEQAALETE 444
++ L + L+ L V+ L + + +V +DL +K +++ L +
Sbjct: 408 EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL-DKADSMIRLLFNDV------ 460
Query: 445 DGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRG 504
QTL+D V A + +LR +G +P + +
Sbjct: 461 ------QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG--VAAPATQVAQVTL 512
Query: 505 RSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERR 564
+S +R P + STL + L V++ + R + ++ G + R
Sbjct: 513 QSVQRRPE---LEDSTLRYLQDLL----AWVEENQHRVDGAE--WGVDLPSVEAQLGSHR 563
Query: 565 ALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQ 624
L + ++ R K + A ++ Q + + L R A L ++ + L
Sbjct: 564 GLHQSIEEFRAKIERARS--DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 621
Query: 625 EREKLQAAQEELRRQRDRLEEE-----------QEDAVQDGARVRRELERSHRQLEQLEG 673
+ AA +EL ++ EEE + + + RELE +++++L+
Sbjct: 622 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 681
Query: 674 KRSVLAKELVEVREALS--RATLQRD---MLQAEKAEVAEALTKAEAGRVELELSMTKLR 728
L +E R + +A LQ MLQ EA K A + + +
Sbjct: 682 AGDRLLREDHPARPTVESFQAALQTQWSWMLQL--CCCIEAHLKENAAYFQFFSDVREAE 739
Query: 729 AEEASLQDSLSKLSALNESLAQDKL-----DLNRLVAQLEEEKSALQGRQRQAEQEATVA 783
+ LQ++L + + + S +L D QL E K L G ++A+ A V
Sbjct: 740 GQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK--AVVQ 797
Query: 784 REEQERLEELR----LEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQ-LAQ 838
+ + +R L + +E ++ ++ Q Q + S E +
Sbjct: 798 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 857
Query: 839 LSRQLSGREQELEQARREAQRQVEALERAARE-----KEALAKEHAGLAVQLVAAEREG- 892
+ + QE ++A + Q +AL + K LA + VQL+ +
Sbjct: 858 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT 917
Query: 893 -RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 951
RTL E R L L F Q A ++L AE + G +
Sbjct: 918 FRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREY---------GSCSHH 968
Query: 952 RQQIIATQEKASLDKELMAQKLVQAEREAQASLR--EQRAAHEEDLQRLQRE--KEAAWR 1007
QQ++ + E+ + +E Q+ + ++ + L E R H L L +E +E A R
Sbjct: 969 YQQLLQSLEQGA-QEESRCQRCISELKDIRLQLEACETRTVHRLRLP-LDKEPARECAQR 1026
Query: 1008 ELEAERAQLQ--------SQLQREQEELLARLEAE------KEELSEEIAALQQERDEGL 1053
E ++AQ + ++L E E++LA E + EL + L+Q R
Sbjct: 1027 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1086
Query: 1054 LLAESEKQQALSLK-----ESEKTALSEKLMGTRHSLATISLEMERQK---RDAQSRQEQ 1105
+ E K +L ++ E A E+L + AT+ E+E K + +++ E
Sbjct: 1087 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEA 1145
Query: 1106 DRSTVNALTSELRDLRAQREEAAAAHAQ---EVRRLQEQARDLGK-------QRDSCLRE 1155
+ T +AL ELR + E H + EV R +E+ L + Q D RE
Sbjct: 1146 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRE 1205
Query: 1156 AEELRTQLRLLEDARDGLRRELLEAQRK--------LRESQEGREVQRQEAGELRRSLGE 1207
E+L QLR ++ D L L +A+R+ L +SQ RE RQE L
Sbjct: 1206 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERH 1265
Query: 1208 GAKEREALRRSNEELRSAVKKAESERISLKLANED--KEQKLALLEEARTAVGKEAGELR 1265
G K E R + + + +A+K E + ++ K E K ++ +V +E +LR
Sbjct: 1266 GEKVEECQRFAKQYI-NAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1324
Query: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLG-RELAELQGRLALGERAEKESRRET 1324
T E+ + + + E R+M+ E RL ++ AE + RLA E A ++ R+
Sbjct: 1325 THYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLA 1380
Query: 1325 LGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHA 1384
Q + E + ++Q +Q + +E + + ++R S++E E QQL +
Sbjct: 1381 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR----SIQE----ELQQLRQS 1432
Query: 1385 RGLELKLEAARAEAAELG-LRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRG 1443
E++ +A +AEAAE LR+ E + + +L E QR AE +L LR+
Sbjct: 1433 SEAEIQAKARQAEAAERSRLRI---EEEIRVVRLQLEATERQRGGAEGELQALRARAEE- 1488
Query: 1444 LGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLD 1503
+ A+ A+ E L + SQ + +
Sbjct: 1489 ----------------AEAQKRQAQEEAERLRR----QVQDESQRKRQAEVELASRVKAE 1528
Query: 1504 PEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAES 1563
EA R E + A + +ELR Q R+L + E ER ARQ+Q A+
Sbjct: 1529 AEAAR--------EKQRALQALEELRLQAEEAERRLRQAEVER------ARQVQVAL--- 1571
Query: 1564 EEARRSVDGRLSG---------VQAELALQEESVR----RSERERRATLDQVATLERSLQ 1610
E A+RS + L Q E +LQEE V R E ERRA Q A ER+ +
Sbjct: 1572 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA--QQQAEAERARE 1629
Query: 1611 ATESELR-------------------ASQEKISKMKANETKLEGD---KRRLKEVLDASE 1648
E EL A Q+ +++ +A + K E + +RR K A
Sbjct: 1630 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1689
Query: 1649 SRTV---KLELQRRSLEG----------ELQRSRLGLSDREAQAQALQDRVDSLQRQVAD 1695
R + +LE QR+ EG EL R R E Q Q L++ + LQR+ A
Sbjct: 1690 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1749
Query: 1696 SEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE----ALAQSSASLNSTRDKNLH 1751
+ K L+ + ++ + + S+ ++ R +E L + ++
Sbjct: 1750 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1809
Query: 1752 LQKALTACEHDRQVLQERLDAARQALSEAR---KQSSSLGEQVQTLRGEVADLELQRVEA 1808
L+ + RQ+ +E DAARQ R ++ +++GE + L+ E A++ L+ EA
Sbjct: 1810 LRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATR-LKTE-AEIALKEKEA 1865
Query: 1809 EGQLQQLREVLRQRQEGEAAALNTVQKLQDERRL-LQERLGSLQRAL-AQLEAEKREVE- 1865
E E LR+ E EA +++ + + ++ERL L++A ++LE +K VE
Sbjct: 1866 E------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1919
Query: 1866 --RSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQ 1923
R ++E++ +AL+ + +K K + R+ + R+ AELE A QRQ
Sbjct: 1920 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQ 1978
Query: 1924 I--QQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQ 1981
+ ++ + E+ E +A +Q+ +EVERL+ A+ E RERA ++
Sbjct: 1979 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK---AKVEEARRLRERAEQE 2035
Query: 1982 RVRGLEEQVSTLKGQLQQE 2000
R L+ + +LQ E
Sbjct: 2036 SARQLQLAQEAAQKRLQAE 2054
Score = 154 bits (389), Expect = 8e-37
Identities = 349/1516 (23%), Positives = 595/1516 (39%), Gaps = 229/1516 (15%)
Query: 550 GTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSA-----NELLSRE 604
G + + L ++S R L +Q L+D G E R V RL E R
Sbjct: 440 GEVERDLDKADSMIRLLFNDVQTLKD---GRHPQGEQMYRRVYRLHERLVAIRTEYNLRL 496
Query: 605 KSNLAH-SLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELER 663
K+ +A + QVAQ + +++ E + L+ +EE Q DGA +L
Sbjct: 497 KAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV--DGAEWGVDLPS 554
Query: 664 SHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ-AEKAEVAEALTKAEAGRVELEL 722
QL G L + + E R + RA L A + + L GR++L+
Sbjct: 555 VEAQL----GSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCL-----GRLDLQY 605
Query: 723 SMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV 782
+ L + +A L+ SL L + + ++ + LN + EEE+ R A
Sbjct: 606 AKL-LNSSKARLR-SLESLHSFVAAATKELMWLN----EKEEEEVGFDWSDRNTNMTA-- 657
Query: 783 AREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 842
++E L E E+ + ++ ++ PT+ ++ LQ Q + + +
Sbjct: 658 ---KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 714
Query: 843 LSGREQELEQAR---------REAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGR 893
E L++ REA+ Q++ L+ A R K + + ++ + + +
Sbjct: 715 CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQ-- 772
Query: 894 TLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQ 953
+E +L K L G L + + + QL+ R G+ LLA +
Sbjct: 773 ---DEKEQLNEYKGHLSG-LAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDY--------K 820
Query: 954 QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013
Q+ T K ++ Q + + + W+ L +
Sbjct: 821 QVEVTVHKG------------------------------DECQLVGPAQPSHWKVLSSSG 850
Query: 1014 AQ--------LQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS 1065
++ L +E +E + RLEA+ + L L + LLA ++ +
Sbjct: 851 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKS--LLAWQSLRRDVQ 908
Query: 1066 LKESEKTALSEKLMGTRHSLATISLEME-----RQKRDAQSRQEQDRSTVNALTSELRDL 1120
L S A L A SLE+ R +DA +DR L
Sbjct: 909 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR------------L 956
Query: 1121 RAQREEAAAAHA-QEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE 1179
A+RE + +H Q++ + EQ + C+ E +++R QL E R R L
Sbjct: 957 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE-TRTVHRLRLPL 1015
Query: 1180 AQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLA 1239
+ RE + R ++Q+A LG+G A L A + R L+L
Sbjct: 1016 DKEPARECAQ-RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT 1074
Query: 1240 NEDKEQKLAL----LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSE 1295
EQ +L LE+ +T G G +EV R+ E +E Q + + L++
Sbjct: 1075 LGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQLKEAQAVPATLPELEAT 1132
Query: 1296 NTRLGRELAELQGRLALGERAEKESR-RETLGLRQRLLKGEASLEVMRQELQVAQRKLQE 1354
L + A+ + + + E R + +G R + GE +EV R +VAQ +
Sbjct: 1133 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1192
Query: 1355 QEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQG 1414
Q +T + R E +QL +L R A LG L A R +
Sbjct: 1193 QAVLAQT----------DVRQRELEQLGR------QLRYYRESADPLGAWLQDARRRQEQ 1236
Query: 1415 LEA-ELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEG 1473
++A LA + R + L R G + A + + +A + +
Sbjct: 1237 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI------NAIKDYELQL 1290
Query: 1474 LNSPSTLE--CSPGSQPPSPGPATSPASPDLDPEAVRGALR-------EFLQELRSAQRE 1524
+ + LE SP +P + S +D L +F+ E E
Sbjct: 1291 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1350
Query: 1525 RDELRTQTSALNRQ-LAEMEAERDSATSRARQLQKAVAESE-EARRSVDGRLSGVQAELA 1582
+ L Q A R+ LAE+EA A + RQL +A A+++ +A R +Q E+
Sbjct: 1351 EERLAEQQRAEERERLAEVEA----ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406
Query: 1583 LQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKE 1642
+EE+ +++++R+ +++ L Q++E+E++A + + + ++E + R ++
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1463
Query: 1643 VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGT 1702
L+A+E QR EGELQ R + EAQ + Q+ + L+RQV D +
Sbjct: 1464 QLEATER-------QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK-- 1514
Query: 1703 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKA-----LT 1757
++E L +V+ EA + +L + + L ++A
Sbjct: 1515 ---------------RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1559
Query: 1758 ACEHDRQVLQERLDAARQALSEARKQSSSLGEQV----QTLRGEVADLELQRVEAEGQLQ 1813
E RQV A R A +E + + +S E+ ++L+ E + R EAE + Q
Sbjct: 1560 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1619
Query: 1814 QLREVLRQRQEGEAAALNTVQKLQDERRL-LQERLGSLQRALAQLEAEKREVERSALRLE 1872
Q E R R+E E K + RL LQ + Q++LAQ EAEK++ E
Sbjct: 1620 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA------ 1673
Query: 1873 KDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV- 1931
+R A RR K E + +R E AE EL E QRQ+ + AQ
Sbjct: 1674 -EREARRR--GKAEEQAVRQREL-----------------AEQEL-EKQRQLAEGTAQQR 1712
Query: 1932 VVLEQSHSPAQLEVDAQQQQLE-LQQEVERL-RSAQAQTERTLEARERAHRQRVRGLEEQ 1989
+ EQ + E + +QQ + L++E+ RL R A A T++ E A +VR E
Sbjct: 1713 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL--EAELAKVRAEMEV 1770
Query: 1990 VSTLKGQLQQELRRSS 2005
+ K + ++E R +S
Sbjct: 1771 LLASKARAEEESRSTS 1786
Score = 48.9 bits (115), Expect = 5e-05
Identities = 48/216 (22%), Positives = 98/216 (45%), Gaps = 17/216 (7%)
Query: 5 LARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPES 64
LA ++V L IQ +S + +L ++ + A + ++ + + +
Sbjct: 2426 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2485
Query: 65 PVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRL 124
LL T+ L E++ LLQ+ E + Q +A+ ++L A +++L + +
Sbjct: 2486 EQLLQETQALQQSFLSEKDSLLQR-----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2540
Query: 125 EPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYK 184
+ ++E QE + LV E RR+ E + RRK + Q+ +Q++ Q + L
Sbjct: 2541 QQQQME-QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL-------- 2591
Query: 185 KRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI 220
+E Q+L E+ LE+Q HS+++ ++ +
Sbjct: 2592 ---AEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2624
Score = 35.4 bits (80), Expect = 0.57
Identities = 89/418 (21%), Positives = 174/418 (41%), Gaps = 43/418 (10%)
Query: 1606 ERSLQATESELRASQEKISKMKANETKL-EGDKRRLKEVLDASESRTVKLELQ------R 1658
ER ++ E+ + K K E E DK R K + + E +L+
Sbjct: 308 ERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP 367
Query: 1659 RSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVE 1718
+E E + + + +RE Q ++ +R++ LQR V +++AG L E+LN
Sbjct: 368 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG---LCEEQLN------- 417
Query: 1719 ESEGALRDKVRGLTEA-LAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQAL 1777
+++ L+ VR L + Q + + DK + + L +D Q L+ D
Sbjct: 418 QADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF---NDVQTLK---DGRHPQG 471
Query: 1778 SEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQ 1837
+ ++ L E++ +R E +L L+ A Q + L+ Q +T++ LQ
Sbjct: 472 EQMYRRVYRLHERLVAIRTEY-NLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ 530
Query: 1838 DERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV 1897
D ++E + A ++ E + + R L +++++ + R+ D
Sbjct: 531 DLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR------GLHQSIEEFRAKIERARSDEG 584
Query: 1898 RLS-AEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL-Q 1955
+LS A +G L +L+ A + + +A++ LE HS A ++ + L +
Sbjct: 585 QLSPATRGAYRDCLGRLDLQYA---KLLNSSKARLRSLESLHS---FVAAATKELMWLNE 638
Query: 1956 QEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQ---QELRRSSAPFSP 2010
+E E + + + A++ ++ +R LE + +K +LQ L R P P
Sbjct: 639 KEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK-ELQNAGDRLLREDHPARP 695
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 266 bits (680), Expect = 2e-70
Identities = 459/1955 (23%), Positives = 813/1955 (41%), Gaps = 297/1955 (15%)
Query: 110 KYNAVSERLEQALR-LEPGELETQEPRGLVRQSVELRRQLQ--EEQASYRRKL------- 159
+Y + S +Q L+ LE G E + + + ++R QL+ E + +R +L
Sbjct: 957 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA 1016
Query: 160 ----QAYQEGQQRQAQL------VQRLQG---KILQYKK---RCSELEQQLLERSGELEQ 203
Q E Q+ QA++ V RL K+L + L +L G+LEQ
Sbjct: 1017 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1076
Query: 204 QR----------------LRDTEHSQD-LESALIRLEEEQQRSASLAQVNAM------LR 240
R +R T+ +++ L + +L+E Q A+L ++ A LR
Sbjct: 1077 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1136
Query: 241 EQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLW 300
Q + AL +++R R ++ R+ R E ++LL W
Sbjct: 1137 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERV--------AQLLERW 1188
Query: 301 RQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAES-RAEAALEK 359
+ V+ ++V+ +R+L QLG +L + G L R E +A +
Sbjct: 1189 QAVLA----QTDVR---QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1241
Query: 360 QALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQV 419
QA+ + +EQ + + ++ Q + + + EL L + + + +
Sbjct: 1242 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK 1301
Query: 420 NKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADA 479
+ E++ +QE L T E T +Q + SE+ ++ ER A+
Sbjct: 1302 KPKVQSGSESV----IQEYVDLRTHYSELTTLT----SQYIKFISETLRRMEEEERLAEQ 1353
Query: 480 SNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMR 539
QR R + +R + A + + A + ++++Q + +R
Sbjct: 1354 ----------QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 540 GRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANE 599
R EA+ D ++ ++R+++E+LQ+LR ++ +QA + R A E
Sbjct: 1404 -REEAAVD-----------AQQQKRSIQEELQQLRQSSEAEIQA---------KARQA-E 1441
Query: 600 LLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
R + + ++V + Q E ++R + + LR + + E ++ A ++ R+RR
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1501
Query: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRA--TLQRDMLQAEKAEVAEALTKAEAGR 717
+++ ++ Q E + + K E RA L+ LQAE+AE + E R
Sbjct: 1502 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Query: 718 VELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAE 777
T R+ EA LQ + + L + + + VAQL EE R+ Q +
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE----RRAQQQ 1617
Query: 778 QEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLA 837
EA AREE ER EL Q A + L L+ E AQ Q+ LA
Sbjct: 1618 AEAERAREEAER--ELERWQLKANEALRLRLQAEEVAQ-----------------QKSLA 1658
Query: 838 QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKE-------HAGLAVQLVAAER 890
Q E++ E+A REA+R+ +A E+A R++E +E G A Q +AAE+
Sbjct: 1659 QAEA-----EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 891 EGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAG 950
E L E + +++ LE L +QR+ A +R++LEAE + E L A
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 951 LRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELE 1010
++ +T EK+ E A + + EA R + A E QR E++AA + E
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAA---RLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 1011 AERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLL--LAESEKQQALSLKE 1068
AER E+L A EA + + EIA ++E + L LAE E Q L+E
Sbjct: 1831 AERVLA--------EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882
Query: 1069 S---EKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQRE 1125
K + E+L R + + E+ERQK + Q R + E+ L+A E
Sbjct: 1883 QAAQHKADIEERLAQLRKASDS---ELERQKGLVEDTLRQRRQ----VEEEILALKASFE 1935
Query: 1126 EAAAAHAQ---EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
+AAA A+ E+ R++ A D + ++ EA R QL E+ R RRE E +
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-QLAAEEERR---RREAEERVQ 1991
Query: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERI-SLKLANE 1241
K ++E QR+ A E E E L+ EE R ++AE E L+LA E
Sbjct: 1992 KSLAAEEEAARQRKAALE----------EVERLKAKVEEARRLRERAEQESARQLQLAQE 2041
Query: 1242 DKEQKLALLEEART-AVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLG 1300
+++L E+A AV ++ EL+ LQ+ + + R E + RR + + +
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2101
Query: 1301 RELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQEL-QVAQRKLQEQEGEF 1359
RE A+ + ++ ER ++ + + Q + +A+ E +R+E Q A R+ Q ++
Sbjct: 2102 REAAQSRRQVEEAERLKQSAEEQA----QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 1360 RTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAEL 1419
R ++ +E+ + +Q L +E +L R L+L + + L+ EL
Sbjct: 2158 RQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR-------LQLEETDHQKNLLDEEL 2209
Query: 1420 ARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPST 1479
R++ + A Q RS + L R
Sbjct: 2210 QRLKAEATEAARQ----RSQVEEELFSVR------------------------------- 2234
Query: 1480 LECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRE--RDELRTQTSALNR 1537
++ S+ + A + A D + + L+E ++++ E R + Q +A R
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 1538 QLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRA 1597
QLAE + + A + +K A E R + L Q ELA +E RR + ++
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA--QEQARRLQEDKEQ 2352
Query: 1598 TLDQVATLERSLQAT-------ESELRASQEK----ISKMKANETKLEGDKRRLKEVLDA 1646
Q+A + Q T + E+ A E+ +++M + + E D +R ++ +
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2412
Query: 1647 SESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLT 1706
+ + EL + +Q + + A+ L++ + L+R+ + +A LQL
Sbjct: 2413 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL- 2471
Query: 1707 VERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNST---RDKNLHLQKALTACEHDR 1763
K EE + ++++ T+AL QS S + R++ + +KA
Sbjct: 2472 ---------KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL-----E 2517
Query: 1764 QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQ 1823
Q+ Q+ + A+Q E ++Q + ++ Q L VA +E EA + + E +R++Q
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASME----EARRRQHEAEEGVRRKQ 2570
Query: 1824 EGEAAALNTVQKLQDERR----LLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALR 1879
E +Q+L+ +RR LL E L+ L LE + R + + +VA
Sbjct: 2571 E-------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2623
Query: 1880 RTLDK---------VEREKLRSHEDTVR-LSAEKGRLDRTLTGAELE-LAEAQRQIQQLE 1928
+TL E E S + R +SA++ + L+ EL+ LA+ + +L
Sbjct: 2624 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2683
Query: 1929 AQVVV---LEQSHSPAQLEVDAQQQQLELQQEVER 1960
+ V L+ S A L + A ++L + ++R
Sbjct: 2684 RREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQR 2718
Score = 263 bits (673), Expect = 1e-69
Identities = 357/1544 (23%), Positives = 644/1544 (41%), Gaps = 172/1544 (11%)
Query: 543 EASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRS-ANELL 601
EA++ L LR Q + AL ++L+ ++ + Q H + EV+R R +LL
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1185
Query: 602 SREKSNLAHSLQVAQQQAEEL----RQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARV 657
R ++ LA + V Q++ E+L R RE L+ R R E+ Q + D V
Sbjct: 1186 ERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1244
Query: 658 RRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGR 717
R +L + LE++E EK E + K
Sbjct: 1245 REQLRQEQALLEEIER--------------------------HGEKVEECQRFAKQYINA 1278
Query: 718 V---ELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQL-----------E 763
+ EL+L K + E + K+ + +ES+ Q+ +DL ++L
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1338
Query: 764 EEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLP 823
E ++ +R AEQ+ EE+ERL E+ E RQ E + QA+ ++
Sbjct: 1339 ETLRRMEEEERLAEQQRA---EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395
Query: 824 TLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEA----LERAAREKEALAKEHA 879
++ E + +E +Q ++EL+Q R+ ++ +++A E A R + + +E
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 880 GLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEAR---REQLEAEGQA 936
+ +QL A ER+ E LR E E + Q + +L + Q + + +
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 937 LLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAE---------------REAQ 981
L ++ E A +Q+ + E+ L E ++L QAE R A+
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 982 ASLREQRAAHEEDLQRLQREKE------AAWRELEAERAQLQSQLQREQEELLARLEA-- 1033
A L+ +RA+ E +L+R + A RE RAQ Q++ +R +EE LE
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 1034 --EKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE 1091
E L + A + + + L AE+EKQ+ + +E+ + +E+ + LA LE
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1695
Query: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHA---QEVRRLQEQARDLGKQ 1148
+RQ + ++Q A EL LRA+ E+ +E+ RLQ +A ++
Sbjct: 1696 KQRQLAEGTAQQRL------AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1749
Query: 1149 RDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLR---ESQEGREVQRQEAGELRRSL 1205
R E ++R ++ +L ++ E K + E++ GR + E R+L
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809
Query: 1206 GEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELR 1265
E AK + L + +A ++AE+ER+ +KLA + EA K E+
Sbjct: 1810 AEEAKRQRQLAEED----AARQRAEAERVLA--------EKLAAIGEATRL--KTEAEIA 1855
Query: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETL 1325
+E E RL RR ++ Q + L+ + + A+++ RLA +A
Sbjct: 1856 LKEKEAENERL--RRLAEDEAFQRRRLEEQ---AAQHKADIEERLAQLRKASDSELERQK 1910
Query: 1326 GLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA-RGTEKQQLDHA 1384
GL + L+ +E L+ + K + E R+ + E+ R E+ +L+ A
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970
Query: 1385 RGLELKLEAARA--EAAE-LGLRLSAAEGRAQGLEAELARVE-VQRRAAEAQLGGLRSAL 1440
R +L E R EA E + L+A E A+ +A L VE ++ + EA+ R+
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2030
Query: 1441 RRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASP 1500
L A A + + A A E TL+ G A
Sbjct: 2031 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ-ELQQTLQQEQSVLDQLRGEA------ 2083
Query: 1501 DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNR--QLAEMEAERDSATSRARQLQK 1558
EA R A E + A+RE + R Q R Q AE +A+ + A + +
Sbjct: 2084 ----EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 1559 AVAESEEARRSVDGRLS-----GVQAELALQEESVRRSERERRATLDQVATLERSLQATE 1613
AE E ARR+ + + AE+ ++ ++ R++ ++ TL L+ T+
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 1614 SELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLS 1673
+ E++ ++KA T+ + +++E L + + +L + +E E L L
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE--NRALILR 2257
Query: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGA----LAKVEE-SEGALRDKV 1728
D++ + LQ+ + + +QVA+ + RL LA+ +E L++K+
Sbjct: 2258 DKDNTQRFLQEEAEKM-KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 1729 RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQ---ERLDAARQALSEARKQSS 1785
+ + EA + + + K L ++A E Q+ Q E ++ L R++
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 1786 SLGEQVQTLRGEVADLELQRVEAEGQLQQLR-------EVLRQRQEGEAAALNTVQKLQD 1838
+ + + L+ VA++ + AE Q+ R E L + + + VQ L+
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 1839 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR 1898
+R+ L+ A+A+LE EK ++++ A L+ + V++E+L
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQ------ 2486
Query: 1899 LSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV 1958
E L ++ + L + +R I+Q +A++ L Q ++ +QQ+ + Q E
Sbjct: 2487 ---ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 1959 ERLRSAQAQTERTLEARERAH--RQRVRGLEEQVSTLKGQLQQE 2000
ER R + EAR R H + VR +E++ L+ Q +Q+
Sbjct: 2544 ERQRLVASME----EARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2583
Score = 234 bits (597), Expect = 6e-61
Identities = 425/1785 (23%), Positives = 742/1785 (41%), Gaps = 230/1785 (12%)
Query: 116 ERLEQALRLEPGELETQEP-----RGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQA 170
E + +L+ + E Q+P R +R + E+ +LQ+ +++ ++E R A
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE---RVA 1182
Query: 171 QLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI---RLEEEQQ 227
QL++R Q + Q R ELEQ ++LR S D A + R +EQ
Sbjct: 1183 QLLERWQAVLAQTDVRQRELEQL---------GRQLRYYRESADPLGAWLQDARRRQEQI 1233
Query: 228 RSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCR----------KELEHREAA 277
++ LA A+ REQL Q QAL E+I + C+ K+ E +
Sbjct: 1234 QAMPLADSQAV-REQLRQ----EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1288
Query: 278 WRRE-----------------EESFNAYFS--NEHSRLLLLWRQVVGFRRLVSEV--KMF 316
++ + E Y +S L L Q + F +SE +M
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF---ISETLRRME 1345
Query: 317 TERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVL 376
E L + R A EA L L A ++A+A E++A +L+++++++V+
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA---KELQQRMQEEVV 1402
Query: 377 REKDLA---QQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL 433
R ++ A QQQ +S ++ + +E + K + + E+ ++ + E + +
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE-----EEIRVV 1457
Query: 434 RLQEQAALETEDG-EGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRT 492
RLQ +A G EG Q LR A+ E+ Q ++ A+ ++ S ++
Sbjct: 1458 RLQLEATERQRGGAEGELQALRARAE------EAEAQKRQAQEEAERLRRQVQDESQRKR 1511
Query: 493 PSPPRRSSPGRGRSPR-RGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGT 551
+ +S + + R A L L +R Q + R R + L
Sbjct: 1512 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQVALETA 1570
Query: 552 LRKQLSDSESERRALEE---QLQR-LRDKTDGAMQAHEDAQREVQR---LRSANELLSRE 604
R ++ +S+R + E QL+R L+++ Q E+A+R Q+ A E RE
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1630
Query: 605 ------KSNLAHSLQVAQQQAEELRQEREKLQAA----QEELRRQRDRLEEEQEDAVQDG 654
K+N A L++ QAEE+ Q++ QA +EE R+ R + +E AV+
Sbjct: 1631 LERWQLKANEALRLRL---QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687
Query: 655 ARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE 714
+ELE+ + E +R +EL+ +R + QR +L+ E A + A
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747
Query: 715 AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQ------LEEEKSA 768
R ELE + K+RAE L SK A ES + + RL A+ L EE +
Sbjct: 1748 QKRQELEAELAKVRAEMEVLL--ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805
Query: 769 LQG------RQRQ-AEQEATVAREEQERL--EELRLEQEVARQGLEG--SLRVAEQAQEA 817
L+ RQRQ AE++A R E ER+ E+L E R E +L+ E E
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1865
Query: 818 LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR-REAQRQVEALERAAREKEALAK 876
L + +R +L+EQ AQ + R +L +A E +RQ +E R++ + +
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 877 EHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARRE-QLEAEGQ 935
E L A L E R+R E S ++ A+LEA R+ QL AE
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRS-----KEQAELEAARQRQLAAE-- 1978
Query: 936 ALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL 995
+E E Q+ +A +E+A+ ++ +++ + + + + + R + A +E
Sbjct: 1979 -----EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033
Query: 996 QRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLL 1055
++LQ +EAA + L+AE +Q++++EL ++ L +E + L Q R E
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL-------QQTLQQEQSVLDQLRGE---- 2082
Query: 1056 AESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTS 1115
AE+ ++ A +E+ A E R E ER K+ A+ Q Q R+ A
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVE-----EAERLKQSAEE-QAQARAQAQAAAE 2136
Query: 1116 ELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRR 1175
+LR A++E A A A++ Q+QA D ++ + AE+ Q +E LR
Sbjct: 2137 KLRK-EAEQEAARRAQAEQAALRQKQAADAEMEKHK--KFAEQTLRQKAQVEQELTTLRL 2193
Query: 1176 ELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERIS 1235
+L E + E + + EA E R + +E ++R EEL + E+E +
Sbjct: 2194 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2253
Query: 1236 LKLANEDKEQKLALLEEARTA--VGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLD 1293
L L ++D Q+ L EEA V +EA L QE R R A +L + R + +
Sbjct: 2254 LILRDKDNTQRF-LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312
Query: 1294 SENTRLGRELAELQGRLAL----GERAEKESRR--------------ETLGL-------R 1328
E + +E L+ L E A++++RR ET G R
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372
Query: 1329 QRLLKGEASLEVMR---QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHAR 1385
QR L+ A E ++ E+ AQ + +E FR + + L ++++ +
Sbjct: 2373 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432
Query: 1386 GLELKLEAARAEAAELGLRLSAAEGRAQGLEAE-----LARVEVQRRAAEAQLGGLRSAL 1440
LE++ + + +A L ++ E + L+ E L E+Q E L ++
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492
Query: 1441 RRGLGLGRAPSPAPRPVPGSPAR------DAPAEGSGEGLNSPSTLECSPGSQPPSPGPA 1494
+ L + R + A+ D A+ + L + Q A
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK--AQQLREEQQRQQQQMEQERQRLVA 2550
Query: 1495 TSPASPDLDPEAVRGALR--EFLQELRSAQRERDE-LRTQTSALNRQLAEMEAERDSATS 1551
+ + EA G R E LQ+L +R+++E L + L QL +E + +A +
Sbjct: 2551 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2610
Query: 1552 RARQLQKAVAESEEARRSVDGRLSGVQAELALQE--ESVRR---SERERRATLDQVATLE 1606
+ ++ + + + + L G AE + + +RR ++R + A + L+
Sbjct: 2611 HSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2670
Query: 1607 RSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDA-SESRTVKLELQRRSLEGEL 1665
R Q + +++++ + L+G +L A +E +V LQR+ L
Sbjct: 2671 RLAQG-----HTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS--- 2722
Query: 1666 QRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR 1725
+ L L + +A + L D V + +R + VK G + L+ L E + +
Sbjct: 2723 PGTALILLEAQAASGFLLDPVRN-RRLTVNEAVKEGVVG---PELHHKLLSAERAVTGYK 2778
Query: 1726 DKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERL 1770
D G +L Q+ +QK L EH ++L+ ++
Sbjct: 2779 DPYTGQQISLFQA-------------MQKGLIVREHGIRLLEAQI 2810
Score = 220 bits (560), Expect = 1e-56
Identities = 342/1419 (24%), Positives = 607/1419 (42%), Gaps = 206/1419 (14%)
Query: 75 SLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEP 134
+L ++EE +L +Q+ + + LA+ A ++ A ++ QA R E EL+ +
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER-EAKELQQRMQ 1398
Query: 135 RGLVRQ------SVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQR------------- 175
+VR+ + + +R +QEE R+ +A + + RQA+ +R
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 176 ------------LQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLE 223
+G++ + R E E Q + E E+ R + + SQ A + L
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518
Query: 224 EEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTR-CRKELEHREAAWRREE 282
+ A A+ + L++ + +R+ + R + LE + + E
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 283 ESFNAYFSNEHSRL-LLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR--TSRAVQEAG 339
+S A F+ + ++L L + V +L E + ++ Q E AR R ++
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ---QAEAERAREEAERELERWQ 1635
Query: 340 LGLSTGLRLAESRAEAALEKQALLQAQLEEQ-------------LRDKVLREKDLAQQQM 386
L + LRL +AE ++++L QA+ E+Q ++ +R+++LA+Q++
Sbjct: 1636 LKANEALRL-RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1694
Query: 387 QSDLDKADLSARVTELGLAVK----RLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALE 442
+ A+ +A+ LA + RL + + +Q + L E+L RLQ +AA
Sbjct: 1695 EKQRQLAEGTAQQR---LAAEQELIRLRAETEQGEQQRQLLEEELA-----RLQREAAAA 1746
Query: 443 TEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPG 502
T+ + L+ L + +E V L+ R + S S S QR + G
Sbjct: 1747 TQKRQELEAELAKVR------AEMEVLLASKARAEEESR-STSEKSKQRL-----EAEAG 1794
Query: 503 RGRSPRRGPSPACSDSSTL-ALIHSALHKRQLQVQDM-RGRYEASQDLLG---------- 550
R R +++ L AL A +RQL +D R R EA + L
Sbjct: 1795 RFRE-------LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1847
Query: 551 -------TLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANEL-LS 602
L+++ +++E RR E++ + R + A Q D + + +LR A++ L
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1907
Query: 603 REKSNLAHSLQVAQQQAEE---LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
R+K + +L+ +Q EE L+ EK A + EL + R+ ED ++ +
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967
Query: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVE 719
E R RQL E +R A+E V+ A ++ E+ E +A K E R
Sbjct: 1968 EAARQ-RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA--KVEEAR-- 2022
Query: 720 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQE 779
R E + Q+S +L E+ AQ +L Q EE+ A +Q++ E +
Sbjct: 2023 --------RLRERAEQESARQLQLAQEA-AQKRL-------QAEEKAHAFAVQQKEQELQ 2066
Query: 780 ATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ-EALEQQLPTLRHER-SQLQEQLA 837
T+ ++EQ L++LR E E AR+ E + QA+ EA + + ER Q E+ A
Sbjct: 2067 QTL-QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Query: 838 QLSRQLSGREQEL-EQARREAQRQVEALERAAREKEA---------------------LA 875
Q Q ++L ++A +EA R+ +A + A R+K+A +
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 876 KEHAGLAVQLVAAEREGRTLSEEATRLRLE-------KEALEGSLFEVQRQLAQLEARRE 928
+E L +QL + + L EE RL+ E + +E LF V+ Q+ +L +
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 929 QLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQR 988
++EAE +AL+L + T + + + + + AQ+ + + A+ L +QR
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR 2305
Query: 989 AAHEEDL-QRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQ 1047
A E+ L +++Q +EA + EAE Q Q +L +EQ RL+ +KE++++++A Q
Sbjct: 2306 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR---RLQEDKEQMAQQLAEETQ 2362
Query: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDR 1107
L E+E+Q+ L E +A +E+L + +A +S R + DAQ ++Q
Sbjct: 2363 GFQRTL---EAERQRQL-----EMSAEAERL---KLRVAEMSRAQARAEEDAQRFRKQAE 2411
Query: 1108 STVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLE 1167
L R A +E+ E++R Q +AE LR + LE
Sbjct: 2412 EIGEKLH---RTELATQEKVTLVQTLEIQRQQSD------------HDAERLREAIAELE 2456
Query: 1168 DARDGLRRELLEAQRKLRESQEGREVQ-RQEAGELRRS-LGEGAKEREALRRSNEELRSA 1225
++ L++E Q K E Q ++ Q QE L++S L E + R +E
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 1226 VKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQEL 1285
+ + E + E+++++ +E+ R + E R E E + ELQ+L
Sbjct: 2517 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2576
Query: 1286 ----RRQMKMLDSENTRLGR--ELAELQGRLALGE----RAEKESRRETLGLRQRLLKGE 1335
R+Q ++L EN RL +L E Q R AL A + + +TL + L G
Sbjct: 2577 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGP 2636
Query: 1336 ASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEAR 1374
A+ +RK+ Q R +E +L + E R
Sbjct: 2637 AAEAEPEHSFDGLRRKVSAQ----RLQEAGILSAEELQR 2671
Score = 195 bits (496), Expect = 3e-49
Identities = 323/1344 (24%), Positives = 558/1344 (41%), Gaps = 216/1344 (16%)
Query: 746 ESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV------AREEQERL-EELRLEQE 798
E AQ++ R +++L++ + L+ + + + ARE +R+ E+ + + E
Sbjct: 973 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE 1032
Query: 799 VARQGLEGSLRVAEQAQE--ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE 856
V G +G R++ +A++ AL + P RS+L+ L +L + S L E
Sbjct: 1033 VEGLG-KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS-----LSAIYLE 1086
Query: 857 AQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEV 916
+ + + R + E + + H EE + E +A+ +L E+
Sbjct: 1087 KLKTISLVIRGTQGAEEVLRAH------------------EEQLK---EAQAVPATLPEL 1125
Query: 917 QRQLAQLEARREQLEAEGQALLLAKETLTG-ELAGLRQQIIATQEKASLDKELMAQKLVQ 975
+ A L+ R Q EA+ ++ L G + G R Q Q D E+ +
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ----QRHGERDVEVERWR--- 1178
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQ------SQLQREQEEL-- 1027
ER AQ R Q + D++ QRE E R+L R +R QE++
Sbjct: 1179 -ERVAQLLERWQAVLAQTDVR--QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1235
Query: 1028 --LARLEAEKEELSEEIAALQQERDEGLLLAESE---KQQALSLKESEKTALSEKLMGTR 1082
LA +A +E+L +E A L++ G + E + KQ ++K+ E
Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL----------- 1284
Query: 1083 HSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQA 1142
L T ++E A+ + Q S ++ E DLR E +Q ++ + E
Sbjct: 1285 -QLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1341
Query: 1143 RDLGKQRDSCLREAEELRTQLRLLEDARDGLR--------------RELLEAQRKLRESQ 1188
R + ++ ++ E R +L +E A + R RE E Q++++E
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 1189 EGREVQRQEAGELRRSLGEGAKEREALRRSNE-ELRSAVKKAES-ERISLKLANEDKEQK 1246
RE +A + +RS+ E E + LR+S+E E+++ ++AE+ ER L++ E + +
Sbjct: 1402 VRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 1247 LAL--LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELA 1304
L L E R E LR +E E + +A+ E + LRRQ++ E+ R +
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQRKRQAEV 1515
Query: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER 1364
EL R+ +AE E+ RE +QR L+ +LE +R + + A+R+L++ E E R R
Sbjct: 1516 ELASRV----KAEAEAARE----KQRALQ---ALEELRLQAEEAERRLRQAEVE---RAR 1561
Query: 1365 RLLGSLEEARGTEKQQLDHARG--------LELKLEAARAEAAELGLRLSAAEGRAQGLE 1416
++ +LE A+ + + +L R LE L+ A+L R A Q E
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL--REEAERRAQQQAE 1619
Query: 1417 AELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNS 1476
AE AR E +R QL ALR L A A AE E
Sbjct: 1620 AERAREEAERELERWQLKA-NEALRLRL-------QAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 1477 PSTLECSPGSQPPSPGPATSPASPDLDPEA--VRGALREFL---QELRSAQRERDELRTQ 1531
+ G A +L+ + G ++ L QEL + E ++ Q
Sbjct: 1672 EARRR---GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1728
Query: 1532 TSALNRQLAEMEAERDSATSRARQLQKAVAE---------SEEARRSVDGRLSGVQAELA 1582
L +LA ++ E +AT + ++L+ +A+ + +AR + R + +++
Sbjct: 1729 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788
Query: 1583 LQEESVR-RSERERRATLDQVAT-LERSLQATESELRASQEKISKMKANETKLEGDKRRL 1640
L+ E+ R R E A L +A +R Q E + + + ++ A + G+ RL
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1848
Query: 1641 KE----VLDASESRTVKLE-------LQRRSLEGELQRSRLGLSDREAQAQALQDR---- 1685
K L E+ +L QRR LE + + + + +R AQ + D
Sbjct: 1849 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1908
Query: 1686 ----VDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSAS 1741
V+ RQ E + L+ + E+ A++E G +R + Q A
Sbjct: 1909 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ--AE 1966
Query: 1742 LNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADL 1801
L + R + L ++ E R+ +ER+ + A EA +Q + E+V+ L+ +V +
Sbjct: 1967 LEAARQRQLAAEE-----ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 1802 ELQRVEAEG----QLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQL 1857
R AE QLQ +E ++R + E A +Q + + LQ+ L Q L QL
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKA--HAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 1858 EAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELEL 1917
E R+A E+ RV + ERE +S ++
Sbjct: 2080 RGEAEAARRAAEEAEEARV-------QAEREAAQSRR---------------------QV 2111
Query: 1918 AEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARER 1977
EA+R Q E EQ+ + AQ + A++ + E +QE R A+ R +A +
Sbjct: 2112 EEAERLKQSAE------EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD- 2164
Query: 1978 AHRQRVRGLEEQVSTLKGQLQQEL 2001
A ++ + EQ K Q++QEL
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQEL 2188
Score = 188 bits (477), Expect = 5e-47
Identities = 438/1879 (23%), Positives = 754/1879 (40%), Gaps = 272/1879 (14%)
Query: 271 LEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR 330
+ H AA+ EE F + F + +LW Q + F+ + K E D + G
Sbjct: 295 MRHHTAAF--EERRFPSSFEE----IEILWSQFLKFKEMELPAK---EADKNRSKGIYQS 345
Query: 331 TSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLR----EKDLAQQQM 386
AVQ L + G + E A+L+ E+QLR + R ++ + + QM
Sbjct: 346 LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILER--EKQLRSEFERLECLQRIVTKLQM 403
Query: 387 QSDLDKADLSARVTELGLAVKRLEKQNLEK--DQVNKDLTEKLEALESLRLQEQAALETE 444
++ L + L+ L V+ L + + +V +DL +K +++ L +
Sbjct: 404 EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL-DKADSMIRLLFNDV------ 456
Query: 445 DGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRG 504
QTL+D V A + +LR +G +P + +
Sbjct: 457 ------QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG--VAAPATQVAQVTL 508
Query: 505 RSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERR 564
+S +R P + STL + L V++ + R + ++ G + R
Sbjct: 509 QSVQRRPE---LEDSTLRYLQDLL----AWVEENQHRVDGAE--WGVDLPSVEAQLGSHR 559
Query: 565 ALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQ 624
L + ++ R K + A ++ Q + + L R A L ++ + L
Sbjct: 560 GLHQSIEEFRAKIERARS--DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 617
Query: 625 EREKLQAAQEELRRQRDRLEEE-----------QEDAVQDGARVRRELERSHRQLEQLEG 673
+ AA +EL ++ EEE + + + RELE +++++L+
Sbjct: 618 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 677
Query: 674 KRSVLAKELVEVREALS--RATLQRD---MLQAEKAEVAEALTKAEAGRVELELSMTKLR 728
L +E R + +A LQ MLQ EA K A + + +
Sbjct: 678 AGDRLLREDHPARPTVESFQAALQTQWSWMLQL--CCCIEAHLKENAAYFQFFSDVREAE 735
Query: 729 AEEASLQDSLSKLSALNESLAQDKL-----DLNRLVAQLEEEKSALQGRQRQAEQEATVA 783
+ LQ++L + + + S +L D QL E K L G ++A+ A V
Sbjct: 736 GQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK--AVVQ 793
Query: 784 REEQERLEELR----LEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQ-LAQ 838
+ + +R L + +E ++ ++ Q Q + S E +
Sbjct: 794 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 853
Query: 839 LSRQLSGREQELEQARREAQRQVEALERAARE-----KEALAKEHAGLAVQLVAAEREG- 892
+ + QE ++A + Q +AL + K LA + VQL+ +
Sbjct: 854 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT 913
Query: 893 -RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 951
RTL E R L L F Q A ++L AE + G +
Sbjct: 914 FRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREY---------GSCSHH 964
Query: 952 RQQIIATQEKASLDKELMAQKLVQAEREAQASLR--EQRAAHEEDLQRLQRE--KEAAWR 1007
QQ++ + E+ + +E Q+ + ++ + L E R H L L +E +E A R
Sbjct: 965 YQQLLQSLEQGA-QEESRCQRCISELKDIRLQLEACETRTVHRLRLP-LDKEPARECAQR 1022
Query: 1008 ELEAERAQLQ--------SQLQREQEELLARLEAE------KEELSEEIAALQQERDEGL 1053
E ++AQ + ++L E E++LA E + EL + L+Q R
Sbjct: 1023 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1082
Query: 1054 LLAESEKQQALSLK-----ESEKTALSEKLMGTRHSLATISLEMERQK---RDAQSRQEQ 1105
+ E K +L ++ E A E+L + AT+ E+E K + +++ E
Sbjct: 1083 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEA 1141
Query: 1106 DRSTVNALTSELRDLRAQREEAAAAHAQ---EVRRLQEQARDLGK-------QRDSCLRE 1155
+ T +AL ELR + E H + EV R +E+ L + Q D RE
Sbjct: 1142 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRE 1201
Query: 1156 AEELRTQLRLLEDARDGLRRELLEAQRK--------LRESQEGREVQRQEAGELRRSLGE 1207
E+L QLR ++ D L L +A+R+ L +SQ RE RQE L
Sbjct: 1202 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERH 1261
Query: 1208 GAKEREALRRSNEELRSAVKKAESERISLKLANED--KEQKLALLEEARTAVGKEAGELR 1265
G K E R + + + +A+K E + ++ K E K ++ +V +E +LR
Sbjct: 1262 GEKVEECQRFAKQYI-NAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1320
Query: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLG-RELAELQGRLALGERAEKESRRET 1324
T E+ + + + E R+M+ E RL ++ AE + RLA E A ++ R+
Sbjct: 1321 THYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLA 1376
Query: 1325 LGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHA 1384
Q + E + ++Q +Q + +E + + ++R S++E E QQL +
Sbjct: 1377 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR----SIQE----ELQQLRQS 1428
Query: 1385 RGLELKLEAARAEAAELG-LRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRG 1443
E++ +A +AEAAE LR+ E + + +L E QR AE +L LR+
Sbjct: 1429 SEAEIQAKARQAEAAERSRLRI---EEEIRVVRLQLEATERQRGGAEGELQALRARAEE- 1484
Query: 1444 LGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLD 1503
+ A+ A+ E L + SQ + +
Sbjct: 1485 ----------------AEAQKRQAQEEAERLRR----QVQDESQRKRQAEVELASRVKAE 1524
Query: 1504 PEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAES 1563
EA R E + A + +ELR Q R+L + E ER ARQ+Q A+
Sbjct: 1525 AEAAR--------EKQRALQALEELRLQAEEAERRLRQAEVER------ARQVQVAL--- 1567
Query: 1564 EEARRSVDGRLSG---------VQAELALQEESVR----RSERERRATLDQVATLERSLQ 1610
E A+RS + L Q E +LQEE V R E ERRA Q A ER+ +
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA--QQQAEAERARE 1625
Query: 1611 ATESELR-------------------ASQEKISKMKANETKLEGD---KRRLKEVLDASE 1648
E EL A Q+ +++ +A + K E + +RR K A
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1685
Query: 1649 SRTV---KLELQRRSLEG----------ELQRSRLGLSDREAQAQALQDRVDSLQRQVAD 1695
R + +LE QR+ EG EL R R E Q Q L++ + LQR+ A
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745
Query: 1696 SEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE----ALAQSSASLNSTRDKNLH 1751
+ K L+ + ++ + + S+ ++ R +E L + ++
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805
Query: 1752 LQKALTACEHDRQVLQERLDAARQALSEAR---KQSSSLGEQVQTLRGEVADLELQRVEA 1808
L+ + RQ+ +E DAARQ R ++ +++GE + L+ E A++ L+ EA
Sbjct: 1806 LRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATR-LKTE-AEIALKEKEA 1861
Query: 1809 EGQLQQLREVLRQRQEGEAAALNTVQKLQDERRL-LQERLGSLQRAL-AQLEAEKREVE- 1865
E E LR+ E EA +++ + + ++ERL L++A ++LE +K VE
Sbjct: 1862 E------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915
Query: 1866 --RSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQ 1923
R ++E++ +AL+ + +K K + R+ + R+ AELE A QRQ
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQ 1974
Query: 1924 I--QQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQ 1981
+ ++ + E+ E +A +Q+ +EVERL+ A+ E RERA ++
Sbjct: 1975 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK---AKVEEARRLRERAEQE 2031
Query: 1982 RVRGLEEQVSTLKGQLQQE 2000
R L+ + +LQ E
Sbjct: 2032 SARQLQLAQEAAQKRLQAE 2050
Score = 154 bits (389), Expect = 8e-37
Identities = 349/1516 (23%), Positives = 595/1516 (39%), Gaps = 229/1516 (15%)
Query: 550 GTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSA-----NELLSRE 604
G + + L ++S R L +Q L+D G E R V RL E R
Sbjct: 436 GEVERDLDKADSMIRLLFNDVQTLKD---GRHPQGEQMYRRVYRLHERLVAIRTEYNLRL 492
Query: 605 KSNLAH-SLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELER 663
K+ +A + QVAQ + +++ E + L+ +EE Q DGA +L
Sbjct: 493 KAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV--DGAEWGVDLPS 550
Query: 664 SHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ-AEKAEVAEALTKAEAGRVELEL 722
QL G L + + E R + RA L A + + L GR++L+
Sbjct: 551 VEAQL----GSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCL-----GRLDLQY 601
Query: 723 SMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV 782
+ L + +A L+ SL L + + ++ + LN + EEE+ R A
Sbjct: 602 AKL-LNSSKARLR-SLESLHSFVAAATKELMWLN----EKEEEEVGFDWSDRNTNMTA-- 653
Query: 783 AREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 842
++E L E E+ + ++ ++ PT+ ++ LQ Q + + +
Sbjct: 654 ---KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 710
Query: 843 LSGREQELEQAR---------REAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGR 893
E L++ REA+ Q++ L+ A R K + + ++ + + +
Sbjct: 711 CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQ-- 768
Query: 894 TLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQ 953
+E +L K L G L + + + QL+ R G+ LLA +
Sbjct: 769 ---DEKEQLNEYKGHLSG-LAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDY--------K 816
Query: 954 QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013
Q+ T K ++ Q + + + W+ L +
Sbjct: 817 QVEVTVHKG------------------------------DECQLVGPAQPSHWKVLSSSG 846
Query: 1014 AQ--------LQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS 1065
++ L +E +E + RLEA+ + L L + LLA ++ +
Sbjct: 847 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKS--LLAWQSLRRDVQ 904
Query: 1066 LKESEKTALSEKLMGTRHSLATISLEME-----RQKRDAQSRQEQDRSTVNALTSELRDL 1120
L S A L A SLE+ R +DA +DR L
Sbjct: 905 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR------------L 952
Query: 1121 RAQREEAAAAHA-QEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE 1179
A+RE + +H Q++ + EQ + C+ E +++R QL E R R L
Sbjct: 953 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE-TRTVHRLRLPL 1011
Query: 1180 AQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLA 1239
+ RE + R ++Q+A LG+G A L A + R L+L
Sbjct: 1012 DKEPARECAQ-RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT 1070
Query: 1240 NEDKEQKLAL----LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSE 1295
EQ +L LE+ +T G G +EV R+ E +E Q + + L++
Sbjct: 1071 LGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQLKEAQAVPATLPELEAT 1128
Query: 1296 NTRLGRELAELQGRLALGERAEKESR-RETLGLRQRLLKGEASLEVMRQELQVAQRKLQE 1354
L + A+ + + + E R + +G R + GE +EV R +VAQ +
Sbjct: 1129 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1188
Query: 1355 QEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQG 1414
Q +T + R E +QL +L R A LG L A R +
Sbjct: 1189 QAVLAQT----------DVRQRELEQLGR------QLRYYRESADPLGAWLQDARRRQEQ 1232
Query: 1415 LEA-ELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEG 1473
++A LA + R + L R G + A + + +A + +
Sbjct: 1233 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI------NAIKDYELQL 1286
Query: 1474 LNSPSTLE--CSPGSQPPSPGPATSPASPDLDPEAVRGALR-------EFLQELRSAQRE 1524
+ + LE SP +P + S +D L +F+ E E
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1346
Query: 1525 RDELRTQTSALNRQ-LAEMEAERDSATSRARQLQKAVAESE-EARRSVDGRLSGVQAELA 1582
+ L Q A R+ LAE+EA A + RQL +A A+++ +A R +Q E+
Sbjct: 1347 EERLAEQQRAEERERLAEVEA----ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 1583 LQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKE 1642
+EE+ +++++R+ +++ L Q++E+E++A + + + ++E + R ++
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459
Query: 1643 VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGT 1702
L+A+E QR EGELQ R + EAQ + Q+ + L+RQV D +
Sbjct: 1460 QLEATER-------QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK-- 1510
Query: 1703 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKA-----LT 1757
++E L +V+ EA + +L + + L ++A
Sbjct: 1511 ---------------RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1555
Query: 1758 ACEHDRQVLQERLDAARQALSEARKQSSSLGEQV----QTLRGEVADLELQRVEAEGQLQ 1813
E RQV A R A +E + + +S E+ ++L+ E + R EAE + Q
Sbjct: 1556 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 1814 QLREVLRQRQEGEAAALNTVQKLQDERRL-LQERLGSLQRALAQLEAEKREVERSALRLE 1872
Q E R R+E E K + RL LQ + Q++LAQ EAEK++ E
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA------ 1669
Query: 1873 KDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV- 1931
+R A RR K E + +R E AE EL E QRQ+ + AQ
Sbjct: 1670 -EREARRR--GKAEEQAVRQREL-----------------AEQEL-EKQRQLAEGTAQQR 1708
Query: 1932 VVLEQSHSPAQLEVDAQQQQLE-LQQEVERL-RSAQAQTERTLEARERAHRQRVRGLEEQ 1989
+ EQ + E + +QQ + L++E+ RL R A A T++ E A +VR E
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL--EAELAKVRAEMEV 1766
Query: 1990 VSTLKGQLQQELRRSS 2005
+ K + ++E R +S
Sbjct: 1767 LLASKARAEEESRSTS 1782
Score = 48.9 bits (115), Expect = 5e-05
Identities = 48/216 (22%), Positives = 98/216 (45%), Gaps = 17/216 (7%)
Query: 5 LARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPES 64
LA ++V L IQ +S + +L ++ + A + ++ + + +
Sbjct: 2422 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2481
Query: 65 PVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRL 124
LL T+ L E++ LLQ+ E + Q +A+ ++L A +++L + +
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQR-----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536
Query: 125 EPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYK 184
+ ++E QE + LV E RR+ E + RRK + Q+ +Q++ Q + L
Sbjct: 2537 QQQQME-QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL-------- 2587
Query: 185 KRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI 220
+E Q+L E+ LE+Q HS+++ ++ +
Sbjct: 2588 ---AEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2620
Score = 35.4 bits (80), Expect = 0.57
Identities = 89/418 (21%), Positives = 174/418 (41%), Gaps = 43/418 (10%)
Query: 1606 ERSLQATESELRASQEKISKMKANETKL-EGDKRRLKEVLDASESRTVKLELQ------R 1658
ER ++ E+ + K K E E DK R K + + E +L+
Sbjct: 304 ERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP 363
Query: 1659 RSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVE 1718
+E E + + + +RE Q ++ +R++ LQR V +++AG L E+LN
Sbjct: 364 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG---LCEEQLN------- 413
Query: 1719 ESEGALRDKVRGLTEA-LAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQAL 1777
+++ L+ VR L + Q + + DK + + L +D Q L+ D
Sbjct: 414 QADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF---NDVQTLK---DGRHPQG 467
Query: 1778 SEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQ 1837
+ ++ L E++ +R E +L L+ A Q + L+ Q +T++ LQ
Sbjct: 468 EQMYRRVYRLHERLVAIRTEY-NLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ 526
Query: 1838 DERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV 1897
D ++E + A ++ E + + R L +++++ + R+ D
Sbjct: 527 DLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR------GLHQSIEEFRAKIERARSDEG 580
Query: 1898 RLS-AEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL-Q 1955
+LS A +G L +L+ A + + +A++ LE HS A ++ + L +
Sbjct: 581 QLSPATRGAYRDCLGRLDLQYA---KLLNSSKARLRSLESLHS---FVAAATKELMWLNE 634
Query: 1956 QEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQ---QELRRSSAPFSP 2010
+E E + + + A++ ++ +R LE + +K +LQ L R P P
Sbjct: 635 KEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK-ELQNAGDRLLREDHPARP 691
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 266 bits (680), Expect = 2e-70
Identities = 459/1955 (23%), Positives = 813/1955 (41%), Gaps = 297/1955 (15%)
Query: 110 KYNAVSERLEQALR-LEPGELETQEPRGLVRQSVELRRQLQ--EEQASYRRKL------- 159
+Y + S +Q L+ LE G E + + + ++R QL+ E + +R +L
Sbjct: 925 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA 984
Query: 160 ----QAYQEGQQRQAQL------VQRLQG---KILQYKK---RCSELEQQLLERSGELEQ 203
Q E Q+ QA++ V RL K+L + L +L G+LEQ
Sbjct: 985 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1044
Query: 204 QR----------------LRDTEHSQD-LESALIRLEEEQQRSASLAQVNAM------LR 240
R +R T+ +++ L + +L+E Q A+L ++ A LR
Sbjct: 1045 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1104
Query: 241 EQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLW 300
Q + AL +++R R ++ R+ R E ++LL W
Sbjct: 1105 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERV--------AQLLERW 1156
Query: 301 RQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAES-RAEAALEK 359
+ V+ ++V+ +R+L QLG +L + G L R E +A +
Sbjct: 1157 QAVLA----QTDVR---QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1209
Query: 360 QALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQV 419
QA+ + +EQ + + ++ Q + + + EL L + + + +
Sbjct: 1210 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK 1269
Query: 420 NKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADA 479
+ E++ +QE L T E T +Q + SE+ ++ ER A+
Sbjct: 1270 KPKVQSGSESV----IQEYVDLRTHYSELTTLT----SQYIKFISETLRRMEEEERLAEQ 1321
Query: 480 SNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMR 539
QR R + +R + A + + A + ++++Q + +R
Sbjct: 1322 ----------QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1371
Query: 540 GRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANE 599
R EA+ D ++ ++R+++E+LQ+LR ++ +QA + R A E
Sbjct: 1372 -REEAAVD-----------AQQQKRSIQEELQQLRQSSEAEIQA---------KARQA-E 1409
Query: 600 LLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
R + + ++V + Q E ++R + + LR + + E ++ A ++ R+RR
Sbjct: 1410 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1469
Query: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRA--TLQRDMLQAEKAEVAEALTKAEAGR 717
+++ ++ Q E + + K E RA L+ LQAE+AE + E R
Sbjct: 1470 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1529
Query: 718 VELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAE 777
T R+ EA LQ + + L + + + VAQL EE R+ Q +
Sbjct: 1530 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE----RRAQQQ 1585
Query: 778 QEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLA 837
EA AREE ER EL Q A + L L+ E AQ Q+ LA
Sbjct: 1586 AEAERAREEAER--ELERWQLKANEALRLRLQAEEVAQ-----------------QKSLA 1626
Query: 838 QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKE-------HAGLAVQLVAAER 890
Q E++ E+A REA+R+ +A E+A R++E +E G A Q +AAE+
Sbjct: 1627 QAEA-----EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1681
Query: 891 EGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAG 950
E L E + +++ LE L +QR+ A +R++LEAE + E L A
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1741
Query: 951 LRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELE 1010
++ +T EK+ E A + + EA R + A E QR E++AA + E
Sbjct: 1742 AEEESRSTSEKSKQRLEAEAGRFRELAEEAA---RLRALAEEAKRQRQLAEEDAARQRAE 1798
Query: 1011 AERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLL--LAESEKQQALSLKE 1068
AER E+L A EA + + EIA ++E + L LAE E Q L+E
Sbjct: 1799 AERVLA--------EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1850
Query: 1069 S---EKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQRE 1125
K + E+L R + + E+ERQK + Q R + E+ L+A E
Sbjct: 1851 QAAQHKADIEERLAQLRKASDS---ELERQKGLVEDTLRQRRQ----VEEEILALKASFE 1903
Query: 1126 EAAAAHAQ---EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
+AAA A+ E+ R++ A D + ++ EA R QL E+ R RRE E +
Sbjct: 1904 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-QLAAEEERR---RREAEERVQ 1959
Query: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERI-SLKLANE 1241
K ++E QR+ A E E E L+ EE R ++AE E L+LA E
Sbjct: 1960 KSLAAEEEAARQRKAALE----------EVERLKAKVEEARRLRERAEQESARQLQLAQE 2009
Query: 1242 DKEQKLALLEEART-AVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLG 1300
+++L E+A AV ++ EL+ LQ+ + + R E + RR + + +
Sbjct: 2010 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2069
Query: 1301 RELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQEL-QVAQRKLQEQEGEF 1359
RE A+ + ++ ER ++ + + Q + +A+ E +R+E Q A R+ Q ++
Sbjct: 2070 REAAQSRRQVEEAERLKQSAEEQA----QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2125
Query: 1360 RTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAEL 1419
R ++ +E+ + +Q L +E +L R L+L + + L+ EL
Sbjct: 2126 RQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR-------LQLEETDHQKNLLDEEL 2177
Query: 1420 ARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPST 1479
R++ + A Q RS + L R
Sbjct: 2178 QRLKAEATEAARQ----RSQVEEELFSVR------------------------------- 2202
Query: 1480 LECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRE--RDELRTQTSALNR 1537
++ S+ + A + A D + + L+E ++++ E R + Q +A R
Sbjct: 2203 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2262
Query: 1538 QLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRA 1597
QLAE + + A + +K A E R + L Q ELA +E RR + ++
Sbjct: 2263 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA--QEQARRLQEDKEQ 2320
Query: 1598 TLDQVATLERSLQAT-------ESELRASQEK----ISKMKANETKLEGDKRRLKEVLDA 1646
Q+A + Q T + E+ A E+ +++M + + E D +R ++ +
Sbjct: 2321 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2380
Query: 1647 SESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLT 1706
+ + EL + +Q + + A+ L++ + L+R+ + +A LQL
Sbjct: 2381 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL- 2439
Query: 1707 VERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNST---RDKNLHLQKALTACEHDR 1763
K EE + ++++ T+AL QS S + R++ + +KA
Sbjct: 2440 ---------KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL-----E 2485
Query: 1764 QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQ 1823
Q+ Q+ + A+Q E ++Q + ++ Q L VA +E EA + + E +R++Q
Sbjct: 2486 QLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASME----EARRRQHEAEEGVRRKQ 2538
Query: 1824 EGEAAALNTVQKLQDERR----LLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALR 1879
E +Q+L+ +RR LL E L+ L LE + R + + +VA
Sbjct: 2539 E-------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2591
Query: 1880 RTLDK---------VEREKLRSHEDTVR-LSAEKGRLDRTLTGAELE-LAEAQRQIQQLE 1928
+TL E E S + R +SA++ + L+ EL+ LA+ + +L
Sbjct: 2592 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2651
Query: 1929 AQVVV---LEQSHSPAQLEVDAQQQQLELQQEVER 1960
+ V L+ S A L + A ++L + ++R
Sbjct: 2652 RREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQR 2686
Score = 263 bits (673), Expect = 1e-69
Identities = 357/1544 (23%), Positives = 644/1544 (41%), Gaps = 172/1544 (11%)
Query: 543 EASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRS-ANELL 601
EA++ L LR Q + AL ++L+ ++ + Q H + EV+R R +LL
Sbjct: 1094 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1153
Query: 602 SREKSNLAHSLQVAQQQAEEL----RQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARV 657
R ++ LA + V Q++ E+L R RE L+ R R E+ Q + D V
Sbjct: 1154 ERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1212
Query: 658 RRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGR 717
R +L + LE++E EK E + K
Sbjct: 1213 REQLRQEQALLEEIER--------------------------HGEKVEECQRFAKQYINA 1246
Query: 718 V---ELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQL-----------E 763
+ EL+L K + E + K+ + +ES+ Q+ +DL ++L
Sbjct: 1247 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1306
Query: 764 EEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLP 823
E ++ +R AEQ+ EE+ERL E+ E RQ E + QA+ ++
Sbjct: 1307 ETLRRMEEEERLAEQQRA---EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1363
Query: 824 TLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEA----LERAAREKEALAKEHA 879
++ E + +E +Q ++EL+Q R+ ++ +++A E A R + + +E
Sbjct: 1364 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1423
Query: 880 GLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEAR---REQLEAEGQA 936
+ +QL A ER+ E LR E E + Q + +L + Q + + +
Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1483
Query: 937 LLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAE---------------REAQ 981
L ++ E A +Q+ + E+ L E ++L QAE R A+
Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543
Query: 982 ASLREQRAAHEEDLQRLQREKE------AAWRELEAERAQLQSQLQREQEELLARLEA-- 1033
A L+ +RA+ E +L+R + A RE RAQ Q++ +R +EE LE
Sbjct: 1544 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1603
Query: 1034 --EKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE 1091
E L + A + + + L AE+EKQ+ + +E+ + +E+ + LA LE
Sbjct: 1604 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1663
Query: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHA---QEVRRLQEQARDLGKQ 1148
+RQ + ++Q A EL LRA+ E+ +E+ RLQ +A ++
Sbjct: 1664 KQRQLAEGTAQQRL------AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1717
Query: 1149 RDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLR---ESQEGREVQRQEAGELRRSL 1205
R E ++R ++ +L ++ E K + E++ GR + E R+L
Sbjct: 1718 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1777
Query: 1206 GEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELR 1265
E AK + L + +A ++AE+ER+ +KLA + EA K E+
Sbjct: 1778 AEEAKRQRQLAEED----AARQRAEAERVLA--------EKLAAIGEATRL--KTEAEIA 1823
Query: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETL 1325
+E E RL RR ++ Q + L+ + + A+++ RLA +A
Sbjct: 1824 LKEKEAENERL--RRLAEDEAFQRRRLEEQ---AAQHKADIEERLAQLRKASDSELERQK 1878
Query: 1326 GLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA-RGTEKQQLDHA 1384
GL + L+ +E L+ + K + E R+ + E+ R E+ +L+ A
Sbjct: 1879 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1938
Query: 1385 RGLELKLEAARA--EAAE-LGLRLSAAEGRAQGLEAELARVE-VQRRAAEAQLGGLRSAL 1440
R +L E R EA E + L+A E A+ +A L VE ++ + EA+ R+
Sbjct: 1939 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 1998
Query: 1441 RRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASP 1500
L A A + + A A E TL+ G A
Sbjct: 1999 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ-ELQQTLQQEQSVLDQLRGEA------ 2051
Query: 1501 DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNR--QLAEMEAERDSATSRARQLQK 1558
EA R A E + A+RE + R Q R Q AE +A+ + A + +
Sbjct: 2052 ----EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2107
Query: 1559 AVAESEEARRSVDGRLS-----GVQAELALQEESVRRSERERRATLDQVATLERSLQATE 1613
AE E ARR+ + + AE+ ++ ++ R++ ++ TL L+ T+
Sbjct: 2108 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2167
Query: 1614 SELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLS 1673
+ E++ ++KA T+ + +++E L + + +L + +E E L L
Sbjct: 2168 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE--NRALILR 2225
Query: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGA----LAKVEE-SEGALRDKV 1728
D++ + LQ+ + + +QVA+ + RL LA+ +E L++K+
Sbjct: 2226 DKDNTQRFLQEEAEKM-KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2284
Query: 1729 RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQ---ERLDAARQALSEARKQSS 1785
+ + EA + + + K L ++A E Q+ Q E ++ L R++
Sbjct: 2285 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2344
Query: 1786 SLGEQVQTLRGEVADLELQRVEAEGQLQQLR-------EVLRQRQEGEAAALNTVQKLQD 1838
+ + + L+ VA++ + AE Q+ R E L + + + VQ L+
Sbjct: 2345 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2404
Query: 1839 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR 1898
+R+ L+ A+A+LE EK ++++ A L+ + V++E+L
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQ------ 2454
Query: 1899 LSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV 1958
E L ++ + L + +R I+Q +A++ L Q ++ +QQ+ + Q E
Sbjct: 2455 ---ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511
Query: 1959 ERLRSAQAQTERTLEARERAH--RQRVRGLEEQVSTLKGQLQQE 2000
ER R + EAR R H + VR +E++ L+ Q +Q+
Sbjct: 2512 ERQRLVASME----EARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2551
Score = 234 bits (597), Expect = 6e-61
Identities = 425/1785 (23%), Positives = 742/1785 (41%), Gaps = 230/1785 (12%)
Query: 116 ERLEQALRLEPGELETQEP-----RGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQA 170
E + +L+ + E Q+P R +R + E+ +LQ+ +++ ++E R A
Sbjct: 1094 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE---RVA 1150
Query: 171 QLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI---RLEEEQQ 227
QL++R Q + Q R ELEQ ++LR S D A + R +EQ
Sbjct: 1151 QLLERWQAVLAQTDVRQRELEQL---------GRQLRYYRESADPLGAWLQDARRRQEQI 1201
Query: 228 RSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCR----------KELEHREAA 277
++ LA A+ REQL Q QAL E+I + C+ K+ E +
Sbjct: 1202 QAMPLADSQAV-REQLRQ----EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1256
Query: 278 WRRE-----------------EESFNAYFS--NEHSRLLLLWRQVVGFRRLVSEV--KMF 316
++ + E Y +S L L Q + F +SE +M
Sbjct: 1257 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF---ISETLRRME 1313
Query: 317 TERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVL 376
E L + R A EA L L A ++A+A E++A +L+++++++V+
Sbjct: 1314 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA---KELQQRMQEEVV 1370
Query: 377 REKDLA---QQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL 433
R ++ A QQQ +S ++ + +E + K + + E+ ++ + E + +
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE-----EEIRVV 1425
Query: 434 RLQEQAALETEDG-EGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRT 492
RLQ +A G EG Q LR A+ E+ Q ++ A+ ++ S ++
Sbjct: 1426 RLQLEATERQRGGAEGELQALRARAE------EAEAQKRQAQEEAERLRRQVQDESQRKR 1479
Query: 493 PSPPRRSSPGRGRSPR-RGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGT 551
+ +S + + R A L L +R Q + R R + L
Sbjct: 1480 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQVALETA 1538
Query: 552 LRKQLSDSESERRALEE---QLQR-LRDKTDGAMQAHEDAQREVQR---LRSANELLSRE 604
R ++ +S+R + E QL+R L+++ Q E+A+R Q+ A E RE
Sbjct: 1539 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1598
Query: 605 ------KSNLAHSLQVAQQQAEELRQEREKLQAA----QEELRRQRDRLEEEQEDAVQDG 654
K+N A L++ QAEE+ Q++ QA +EE R+ R + +E AV+
Sbjct: 1599 LERWQLKANEALRLRL---QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1655
Query: 655 ARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE 714
+ELE+ + E +R +EL+ +R + QR +L+ E A + A
Sbjct: 1656 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1715
Query: 715 AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQ------LEEEKSA 768
R ELE + K+RAE L SK A ES + + RL A+ L EE +
Sbjct: 1716 QKRQELEAELAKVRAEMEVLL--ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1773
Query: 769 LQG------RQRQ-AEQEATVAREEQERL--EELRLEQEVARQGLEG--SLRVAEQAQEA 817
L+ RQRQ AE++A R E ER+ E+L E R E +L+ E E
Sbjct: 1774 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1833
Query: 818 LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR-REAQRQVEALERAAREKEALAK 876
L + +R +L+EQ AQ + R +L +A E +RQ +E R++ + +
Sbjct: 1834 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1893
Query: 877 EHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARRE-QLEAEGQ 935
E L A L E R+R E S ++ A+LEA R+ QL AE
Sbjct: 1894 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRS-----KEQAELEAARQRQLAAE-- 1946
Query: 936 ALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL 995
+E E Q+ +A +E+A+ ++ +++ + + + + + R + A +E
Sbjct: 1947 -----EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2001
Query: 996 QRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLL 1055
++LQ +EAA + L+AE +Q++++EL ++ L +E + L Q R E
Sbjct: 2002 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL-------QQTLQQEQSVLDQLRGE---- 2050
Query: 1056 AESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTS 1115
AE+ ++ A +E+ A E R E ER K+ A+ Q Q R+ A
Sbjct: 2051 AEAARRAAEEAEEARVQAEREAAQSRRQVE-----EAERLKQSAEE-QAQARAQAQAAAE 2104
Query: 1116 ELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRR 1175
+LR A++E A A A++ Q+QA D ++ + AE+ Q +E LR
Sbjct: 2105 KLRK-EAEQEAARRAQAEQAALRQKQAADAEMEKHK--KFAEQTLRQKAQVEQELTTLRL 2161
Query: 1176 ELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERIS 1235
+L E + E + + EA E R + +E ++R EEL + E+E +
Sbjct: 2162 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2221
Query: 1236 LKLANEDKEQKLALLEEARTA--VGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLD 1293
L L ++D Q+ L EEA V +EA L QE R R A +L + R + +
Sbjct: 2222 LILRDKDNTQRF-LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2280
Query: 1294 SENTRLGRELAELQGRLAL----GERAEKESRR--------------ETLGL-------R 1328
E + +E L+ L E A++++RR ET G R
Sbjct: 2281 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2340
Query: 1329 QRLLKGEASLEVMR---QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHAR 1385
QR L+ A E ++ E+ AQ + +E FR + + L ++++ +
Sbjct: 2341 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2400
Query: 1386 GLELKLEAARAEAAELGLRLSAAEGRAQGLEAE-----LARVEVQRRAAEAQLGGLRSAL 1440
LE++ + + +A L ++ E + L+ E L E+Q E L ++
Sbjct: 2401 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2460
Query: 1441 RRGLGLGRAPSPAPRPVPGSPAR------DAPAEGSGEGLNSPSTLECSPGSQPPSPGPA 1494
+ L + R + A+ D A+ + L + Q A
Sbjct: 2461 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK--AQQLREEQQRQQQQMEQERQRLVA 2518
Query: 1495 TSPASPDLDPEAVRGALR--EFLQELRSAQRERDE-LRTQTSALNRQLAEMEAERDSATS 1551
+ + EA G R E LQ+L +R+++E L + L QL +E + +A +
Sbjct: 2519 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2578
Query: 1552 RARQLQKAVAESEEARRSVDGRLSGVQAELALQE--ESVRR---SERERRATLDQVATLE 1606
+ ++ + + + + L G AE + + +RR ++R + A + L+
Sbjct: 2579 HSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2638
Query: 1607 RSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDA-SESRTVKLELQRRSLEGEL 1665
R Q + +++++ + L+G +L A +E +V LQR+ L
Sbjct: 2639 RLAQG-----HTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS--- 2690
Query: 1666 QRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR 1725
+ L L + +A + L D V + +R + VK G + L+ L E + +
Sbjct: 2691 PGTALILLEAQAASGFLLDPVRN-RRLTVNEAVKEGVVG---PELHHKLLSAERAVTGYK 2746
Query: 1726 DKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERL 1770
D G +L Q+ +QK L EH ++L+ ++
Sbjct: 2747 DPYTGQQISLFQA-------------MQKGLIVREHGIRLLEAQI 2778
Score = 220 bits (560), Expect = 1e-56
Identities = 342/1419 (24%), Positives = 607/1419 (42%), Gaps = 206/1419 (14%)
Query: 75 SLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEP 134
+L ++EE +L +Q+ + + LA+ A ++ A ++ QA R E EL+ +
Sbjct: 1308 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER-EAKELQQRMQ 1366
Query: 135 RGLVRQ------SVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQR------------- 175
+VR+ + + +R +QEE R+ +A + + RQA+ +R
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1426
Query: 176 ------------LQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLE 223
+G++ + R E E Q + E E+ R + + SQ A + L
Sbjct: 1427 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1486
Query: 224 EEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTR-CRKELEHREAAWRREE 282
+ A A+ + L++ + +R+ + R + LE + + E
Sbjct: 1487 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1546
Query: 283 ESFNAYFSNEHSRL-LLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR--TSRAVQEAG 339
+S A F+ + ++L L + V +L E + ++ Q E AR R ++
Sbjct: 1547 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ---QAEAERAREEAERELERWQ 1603
Query: 340 LGLSTGLRLAESRAEAALEKQALLQAQLEEQ-------------LRDKVLREKDLAQQQM 386
L + LRL +AE ++++L QA+ E+Q ++ +R+++LA+Q++
Sbjct: 1604 LKANEALRL-RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1662
Query: 387 QSDLDKADLSARVTELGLAVK----RLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALE 442
+ A+ +A+ LA + RL + + +Q + L E+L RLQ +AA
Sbjct: 1663 EKQRQLAEGTAQQR---LAAEQELIRLRAETEQGEQQRQLLEEELA-----RLQREAAAA 1714
Query: 443 TEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPG 502
T+ + L+ L + +E V L+ R + S S S QR + G
Sbjct: 1715 TQKRQELEAELAKVR------AEMEVLLASKARAEEESR-STSEKSKQRL-----EAEAG 1762
Query: 503 RGRSPRRGPSPACSDSSTL-ALIHSALHKRQLQVQDM-RGRYEASQDLLG---------- 550
R R +++ L AL A +RQL +D R R EA + L
Sbjct: 1763 RFRE-------LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1815
Query: 551 -------TLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANEL-LS 602
L+++ +++E RR E++ + R + A Q D + + +LR A++ L
Sbjct: 1816 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1875
Query: 603 REKSNLAHSLQVAQQQAEE---LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
R+K + +L+ +Q EE L+ EK A + EL + R+ ED ++ +
Sbjct: 1876 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1935
Query: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVE 719
E R RQL E +R A+E V+ A ++ E+ E +A K E R
Sbjct: 1936 EAARQ-RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA--KVEEAR-- 1990
Query: 720 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQE 779
R E + Q+S +L E+ AQ +L Q EE+ A +Q++ E +
Sbjct: 1991 --------RLRERAEQESARQLQLAQEA-AQKRL-------QAEEKAHAFAVQQKEQELQ 2034
Query: 780 ATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ-EALEQQLPTLRHER-SQLQEQLA 837
T+ ++EQ L++LR E E AR+ E + QA+ EA + + ER Q E+ A
Sbjct: 2035 QTL-QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2093
Query: 838 QLSRQLSGREQEL-EQARREAQRQVEALERAAREKEA---------------------LA 875
Q Q ++L ++A +EA R+ +A + A R+K+A +
Sbjct: 2094 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2153
Query: 876 KEHAGLAVQLVAAEREGRTLSEEATRLRLE-------KEALEGSLFEVQRQLAQLEARRE 928
+E L +QL + + L EE RL+ E + +E LF V+ Q+ +L +
Sbjct: 2154 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2213
Query: 929 QLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQR 988
++EAE +AL+L + T + + + + + AQ+ + + A+ L +QR
Sbjct: 2214 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR 2273
Query: 989 AAHEEDL-QRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQ 1047
A E+ L +++Q +EA + EAE Q Q +L +EQ RL+ +KE++++++A Q
Sbjct: 2274 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR---RLQEDKEQMAQQLAEETQ 2330
Query: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDR 1107
L E+E+Q+ L E +A +E+L + +A +S R + DAQ ++Q
Sbjct: 2331 GFQRTL---EAERQRQL-----EMSAEAERL---KLRVAEMSRAQARAEEDAQRFRKQAE 2379
Query: 1108 STVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLE 1167
L R A +E+ E++R Q +AE LR + LE
Sbjct: 2380 EIGEKLH---RTELATQEKVTLVQTLEIQRQQSD------------HDAERLREAIAELE 2424
Query: 1168 DARDGLRRELLEAQRKLRESQEGREVQ-RQEAGELRRS-LGEGAKEREALRRSNEELRSA 1225
++ L++E Q K E Q ++ Q QE L++S L E + R +E
Sbjct: 2425 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2484
Query: 1226 VKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQEL 1285
+ + E + E+++++ +E+ R + E R E E + ELQ+L
Sbjct: 2485 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2544
Query: 1286 ----RRQMKMLDSENTRLGR--ELAELQGRLALGE----RAEKESRRETLGLRQRLLKGE 1335
R+Q ++L EN RL +L E Q R AL A + + +TL + L G
Sbjct: 2545 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGP 2604
Query: 1336 ASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEAR 1374
A+ +RK+ Q R +E +L + E R
Sbjct: 2605 AAEAEPEHSFDGLRRKVSAQ----RLQEAGILSAEELQR 2639
Score = 195 bits (496), Expect = 3e-49
Identities = 323/1344 (24%), Positives = 558/1344 (41%), Gaps = 216/1344 (16%)
Query: 746 ESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV------AREEQERL-EELRLEQE 798
E AQ++ R +++L++ + L+ + + + ARE +R+ E+ + + E
Sbjct: 941 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE 1000
Query: 799 VARQGLEGSLRVAEQAQE--ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE 856
V G +G R++ +A++ AL + P RS+L+ L +L + S L E
Sbjct: 1001 VEGLG-KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS-----LSAIYLE 1054
Query: 857 AQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEV 916
+ + + R + E + + H EE + E +A+ +L E+
Sbjct: 1055 KLKTISLVIRGTQGAEEVLRAH------------------EEQLK---EAQAVPATLPEL 1093
Query: 917 QRQLAQLEARREQLEAEGQALLLAKETLTG-ELAGLRQQIIATQEKASLDKELMAQKLVQ 975
+ A L+ R Q EA+ ++ L G + G R Q Q D E+ +
Sbjct: 1094 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ----QRHGERDVEVERWR--- 1146
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQ------SQLQREQEEL-- 1027
ER AQ R Q + D++ QRE E R+L R +R QE++
Sbjct: 1147 -ERVAQLLERWQAVLAQTDVR--QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1203
Query: 1028 --LARLEAEKEELSEEIAALQQERDEGLLLAESE---KQQALSLKESEKTALSEKLMGTR 1082
LA +A +E+L +E A L++ G + E + KQ ++K+ E
Sbjct: 1204 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL----------- 1252
Query: 1083 HSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQA 1142
L T ++E A+ + Q S ++ E DLR E +Q ++ + E
Sbjct: 1253 -QLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1309
Query: 1143 RDLGKQRDSCLREAEELRTQLRLLEDARDGLR--------------RELLEAQRKLRESQ 1188
R + ++ ++ E R +L +E A + R RE E Q++++E
Sbjct: 1310 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1369
Query: 1189 EGREVQRQEAGELRRSLGEGAKEREALRRSNE-ELRSAVKKAES-ERISLKLANEDKEQK 1246
RE +A + +RS+ E E + LR+S+E E+++ ++AE+ ER L++ E + +
Sbjct: 1370 VRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1426
Query: 1247 LAL--LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELA 1304
L L E R E LR +E E + +A+ E + LRRQ++ E+ R +
Sbjct: 1427 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQRKRQAEV 1483
Query: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER 1364
EL R+ +AE E+ RE +QR L+ +LE +R + + A+R+L++ E E R R
Sbjct: 1484 ELASRV----KAEAEAARE----KQRALQ---ALEELRLQAEEAERRLRQAEVE---RAR 1529
Query: 1365 RLLGSLEEARGTEKQQLDHARG--------LELKLEAARAEAAELGLRLSAAEGRAQGLE 1416
++ +LE A+ + + +L R LE L+ A+L R A Q E
Sbjct: 1530 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL--REEAERRAQQQAE 1587
Query: 1417 AELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNS 1476
AE AR E +R QL ALR L A A AE E
Sbjct: 1588 AERAREEAERELERWQLKA-NEALRLRL-------QAEEVAQQKSLAQAEAEKQKEEAER 1639
Query: 1477 PSTLECSPGSQPPSPGPATSPASPDLDPEA--VRGALREFL---QELRSAQRERDELRTQ 1531
+ G A +L+ + G ++ L QEL + E ++ Q
Sbjct: 1640 EARRR---GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1696
Query: 1532 TSALNRQLAEMEAERDSATSRARQLQKAVAE---------SEEARRSVDGRLSGVQAELA 1582
L +LA ++ E +AT + ++L+ +A+ + +AR + R + +++
Sbjct: 1697 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1756
Query: 1583 LQEESVR-RSERERRATLDQVAT-LERSLQATESELRASQEKISKMKANETKLEGDKRRL 1640
L+ E+ R R E A L +A +R Q E + + + ++ A + G+ RL
Sbjct: 1757 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1816
Query: 1641 KE----VLDASESRTVKLE-------LQRRSLEGELQRSRLGLSDREAQAQALQDR---- 1685
K L E+ +L QRR LE + + + + +R AQ + D
Sbjct: 1817 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1876
Query: 1686 ----VDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSAS 1741
V+ RQ E + L+ + E+ A++E G +R + Q A
Sbjct: 1877 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ--AE 1934
Query: 1742 LNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADL 1801
L + R + L ++ E R+ +ER+ + A EA +Q + E+V+ L+ +V +
Sbjct: 1935 LEAARQRQLAAEE-----ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1989
Query: 1802 ELQRVEAEG----QLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQL 1857
R AE QLQ +E ++R + E A +Q + + LQ+ L Q L QL
Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQKRLQAEEKA--HAFAVQQKEQELQQTLQQEQSVLDQL 2047
Query: 1858 EAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELEL 1917
E R+A E+ RV + ERE +S ++
Sbjct: 2048 RGEAEAARRAAEEAEEARV-------QAEREAAQSRR---------------------QV 2079
Query: 1918 AEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARER 1977
EA+R Q E EQ+ + AQ + A++ + E +QE R A+ R +A +
Sbjct: 2080 EEAERLKQSAE------EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD- 2132
Query: 1978 AHRQRVRGLEEQVSTLKGQLQQEL 2001
A ++ + EQ K Q++QEL
Sbjct: 2133 AEMEKHKKFAEQTLRQKAQVEQEL 2156
Score = 188 bits (477), Expect = 5e-47
Identities = 438/1879 (23%), Positives = 754/1879 (40%), Gaps = 272/1879 (14%)
Query: 271 LEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR 330
+ H AA+ EE F + F + +LW Q + F+ + K E D + G
Sbjct: 263 MRHHTAAF--EERRFPSSFEE----IEILWSQFLKFKEMELPAK---EADKNRSKGIYQS 313
Query: 331 TSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLR----EKDLAQQQM 386
AVQ L + G + E A+L+ E+QLR + R ++ + + QM
Sbjct: 314 LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILER--EKQLRSEFERLECLQRIVTKLQM 371
Query: 387 QSDLDKADLSARVTELGLAVKRLEKQNLEK--DQVNKDLTEKLEALESLRLQEQAALETE 444
++ L + L+ L V+ L + + +V +DL +K +++ L +
Sbjct: 372 EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL-DKADSMIRLLFNDV------ 424
Query: 445 DGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRG 504
QTL+D V A + +LR +G +P + +
Sbjct: 425 ------QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG--VAAPATQVAQVTL 476
Query: 505 RSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERR 564
+S +R P + STL + L V++ + R + ++ G + R
Sbjct: 477 QSVQRRPE---LEDSTLRYLQDLL----AWVEENQHRVDGAE--WGVDLPSVEAQLGSHR 527
Query: 565 ALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQ 624
L + ++ R K + A ++ Q + + L R A L ++ + L
Sbjct: 528 GLHQSIEEFRAKIERARS--DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 585
Query: 625 EREKLQAAQEELRRQRDRLEEE-----------QEDAVQDGARVRRELERSHRQLEQLEG 673
+ AA +EL ++ EEE + + + RELE +++++L+
Sbjct: 586 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 645
Query: 674 KRSVLAKELVEVREALS--RATLQRD---MLQAEKAEVAEALTKAEAGRVELELSMTKLR 728
L +E R + +A LQ MLQ EA K A + + +
Sbjct: 646 AGDRLLREDHPARPTVESFQAALQTQWSWMLQL--CCCIEAHLKENAAYFQFFSDVREAE 703
Query: 729 AEEASLQDSLSKLSALNESLAQDKL-----DLNRLVAQLEEEKSALQGRQRQAEQEATVA 783
+ LQ++L + + + S +L D QL E K L G ++A+ A V
Sbjct: 704 GQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK--AVVQ 761
Query: 784 REEQERLEELR----LEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQ-LAQ 838
+ + +R L + +E ++ ++ Q Q + S E +
Sbjct: 762 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 821
Query: 839 LSRQLSGREQELEQARREAQRQVEALERAARE-----KEALAKEHAGLAVQLVAAEREG- 892
+ + QE ++A + Q +AL + K LA + VQL+ +
Sbjct: 822 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT 881
Query: 893 -RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 951
RTL E R L L F Q A ++L AE + G +
Sbjct: 882 FRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREY---------GSCSHH 932
Query: 952 RQQIIATQEKASLDKELMAQKLVQAEREAQASLR--EQRAAHEEDLQRLQRE--KEAAWR 1007
QQ++ + E+ + +E Q+ + ++ + L E R H L L +E +E A R
Sbjct: 933 YQQLLQSLEQGA-QEESRCQRCISELKDIRLQLEACETRTVHRLRLP-LDKEPARECAQR 990
Query: 1008 ELEAERAQLQ--------SQLQREQEELLARLEAE------KEELSEEIAALQQERDEGL 1053
E ++AQ + ++L E E++LA E + EL + L+Q R
Sbjct: 991 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1050
Query: 1054 LLAESEKQQALSLK-----ESEKTALSEKLMGTRHSLATISLEMERQK---RDAQSRQEQ 1105
+ E K +L ++ E A E+L + AT+ E+E K + +++ E
Sbjct: 1051 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEA 1109
Query: 1106 DRSTVNALTSELRDLRAQREEAAAAHAQ---EVRRLQEQARDLGK-------QRDSCLRE 1155
+ T +AL ELR + E H + EV R +E+ L + Q D RE
Sbjct: 1110 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRE 1169
Query: 1156 AEELRTQLRLLEDARDGLRRELLEAQRK--------LRESQEGREVQRQEAGELRRSLGE 1207
E+L QLR ++ D L L +A+R+ L +SQ RE RQE L
Sbjct: 1170 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERH 1229
Query: 1208 GAKEREALRRSNEELRSAVKKAESERISLKLANED--KEQKLALLEEARTAVGKEAGELR 1265
G K E R + + + +A+K E + ++ K E K ++ +V +E +LR
Sbjct: 1230 GEKVEECQRFAKQYI-NAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1288
Query: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLG-RELAELQGRLALGERAEKESRRET 1324
T E+ + + + E R+M+ E RL ++ AE + RLA E A ++ R+
Sbjct: 1289 THYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLA 1344
Query: 1325 LGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHA 1384
Q + E + ++Q +Q + +E + + ++R S++E E QQL +
Sbjct: 1345 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR----SIQE----ELQQLRQS 1396
Query: 1385 RGLELKLEAARAEAAELG-LRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRG 1443
E++ +A +AEAAE LR+ E + + +L E QR AE +L LR+
Sbjct: 1397 SEAEIQAKARQAEAAERSRLRI---EEEIRVVRLQLEATERQRGGAEGELQALRARAEE- 1452
Query: 1444 LGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLD 1503
+ A+ A+ E L + SQ + +
Sbjct: 1453 ----------------AEAQKRQAQEEAERLRR----QVQDESQRKRQAEVELASRVKAE 1492
Query: 1504 PEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAES 1563
EA R E + A + +ELR Q R+L + E ER ARQ+Q A+
Sbjct: 1493 AEAAR--------EKQRALQALEELRLQAEEAERRLRQAEVER------ARQVQVAL--- 1535
Query: 1564 EEARRSVDGRLSG---------VQAELALQEESVR----RSERERRATLDQVATLERSLQ 1610
E A+RS + L Q E +LQEE V R E ERRA Q A ER+ +
Sbjct: 1536 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA--QQQAEAERARE 1593
Query: 1611 ATESELR-------------------ASQEKISKMKANETKLEGD---KRRLKEVLDASE 1648
E EL A Q+ +++ +A + K E + +RR K A
Sbjct: 1594 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1653
Query: 1649 SRTV---KLELQRRSLEG----------ELQRSRLGLSDREAQAQALQDRVDSLQRQVAD 1695
R + +LE QR+ EG EL R R E Q Q L++ + LQR+ A
Sbjct: 1654 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1713
Query: 1696 SEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE----ALAQSSASLNSTRDKNLH 1751
+ K L+ + ++ + + S+ ++ R +E L + ++
Sbjct: 1714 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1773
Query: 1752 LQKALTACEHDRQVLQERLDAARQALSEAR---KQSSSLGEQVQTLRGEVADLELQRVEA 1808
L+ + RQ+ +E DAARQ R ++ +++GE + L+ E A++ L+ EA
Sbjct: 1774 LRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATR-LKTE-AEIALKEKEA 1829
Query: 1809 EGQLQQLREVLRQRQEGEAAALNTVQKLQDERRL-LQERLGSLQRAL-AQLEAEKREVE- 1865
E E LR+ E EA +++ + + ++ERL L++A ++LE +K VE
Sbjct: 1830 E------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1883
Query: 1866 --RSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQ 1923
R ++E++ +AL+ + +K K + R+ + R+ AELE A QRQ
Sbjct: 1884 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQ 1942
Query: 1924 I--QQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQ 1981
+ ++ + E+ E +A +Q+ +EVERL+ A+ E RERA ++
Sbjct: 1943 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK---AKVEEARRLRERAEQE 1999
Query: 1982 RVRGLEEQVSTLKGQLQQE 2000
R L+ + +LQ E
Sbjct: 2000 SARQLQLAQEAAQKRLQAE 2018
Score = 154 bits (389), Expect = 8e-37
Identities = 349/1516 (23%), Positives = 595/1516 (39%), Gaps = 229/1516 (15%)
Query: 550 GTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSA-----NELLSRE 604
G + + L ++S R L +Q L+D G E R V RL E R
Sbjct: 404 GEVERDLDKADSMIRLLFNDVQTLKD---GRHPQGEQMYRRVYRLHERLVAIRTEYNLRL 460
Query: 605 KSNLAH-SLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELER 663
K+ +A + QVAQ + +++ E + L+ +EE Q DGA +L
Sbjct: 461 KAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV--DGAEWGVDLPS 518
Query: 664 SHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ-AEKAEVAEALTKAEAGRVELEL 722
QL G L + + E R + RA L A + + L GR++L+
Sbjct: 519 VEAQL----GSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCL-----GRLDLQY 569
Query: 723 SMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV 782
+ L + +A L+ SL L + + ++ + LN + EEE+ R A
Sbjct: 570 AKL-LNSSKARLR-SLESLHSFVAAATKELMWLN----EKEEEEVGFDWSDRNTNMTA-- 621
Query: 783 AREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 842
++E L E E+ + ++ ++ PT+ ++ LQ Q + + +
Sbjct: 622 ---KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 678
Query: 843 LSGREQELEQAR---------REAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGR 893
E L++ REA+ Q++ L+ A R K + + ++ + + +
Sbjct: 679 CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQ-- 736
Query: 894 TLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQ 953
+E +L K L G L + + + QL+ R G+ LLA +
Sbjct: 737 ---DEKEQLNEYKGHLSG-LAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDY--------K 784
Query: 954 QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013
Q+ T K ++ Q + + + W+ L +
Sbjct: 785 QVEVTVHKG------------------------------DECQLVGPAQPSHWKVLSSSG 814
Query: 1014 AQ--------LQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS 1065
++ L +E +E + RLEA+ + L L + LLA ++ +
Sbjct: 815 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKS--LLAWQSLRRDVQ 872
Query: 1066 LKESEKTALSEKLMGTRHSLATISLEME-----RQKRDAQSRQEQDRSTVNALTSELRDL 1120
L S A L A SLE+ R +DA +DR L
Sbjct: 873 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR------------L 920
Query: 1121 RAQREEAAAAHA-QEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE 1179
A+RE + +H Q++ + EQ + C+ E +++R QL E R R L
Sbjct: 921 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE-TRTVHRLRLPL 979
Query: 1180 AQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLA 1239
+ RE + R ++Q+A LG+G A L A + R L+L
Sbjct: 980 DKEPARECAQ-RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT 1038
Query: 1240 NEDKEQKLAL----LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSE 1295
EQ +L LE+ +T G G +EV R+ E +E Q + + L++
Sbjct: 1039 LGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQLKEAQAVPATLPELEAT 1096
Query: 1296 NTRLGRELAELQGRLALGERAEKESR-RETLGLRQRLLKGEASLEVMRQELQVAQRKLQE 1354
L + A+ + + + E R + +G R + GE +EV R +VAQ +
Sbjct: 1097 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1156
Query: 1355 QEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQG 1414
Q +T + R E +QL +L R A LG L A R +
Sbjct: 1157 QAVLAQT----------DVRQRELEQLGR------QLRYYRESADPLGAWLQDARRRQEQ 1200
Query: 1415 LEA-ELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEG 1473
++A LA + R + L R G + A + + +A + +
Sbjct: 1201 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI------NAIKDYELQL 1254
Query: 1474 LNSPSTLE--CSPGSQPPSPGPATSPASPDLDPEAVRGALR-------EFLQELRSAQRE 1524
+ + LE SP +P + S +D L +F+ E E
Sbjct: 1255 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1314
Query: 1525 RDELRTQTSALNRQ-LAEMEAERDSATSRARQLQKAVAESE-EARRSVDGRLSGVQAELA 1582
+ L Q A R+ LAE+EA A + RQL +A A+++ +A R +Q E+
Sbjct: 1315 EERLAEQQRAEERERLAEVEA----ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370
Query: 1583 LQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKE 1642
+EE+ +++++R+ +++ L Q++E+E++A + + + ++E + R ++
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1427
Query: 1643 VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGT 1702
L+A+E QR EGELQ R + EAQ + Q+ + L+RQV D +
Sbjct: 1428 QLEATER-------QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK-- 1478
Query: 1703 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKA-----LT 1757
++E L +V+ EA + +L + + L ++A
Sbjct: 1479 ---------------RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1523
Query: 1758 ACEHDRQVLQERLDAARQALSEARKQSSSLGEQV----QTLRGEVADLELQRVEAEGQLQ 1813
E RQV A R A +E + + +S E+ ++L+ E + R EAE + Q
Sbjct: 1524 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1583
Query: 1814 QLREVLRQRQEGEAAALNTVQKLQDERRL-LQERLGSLQRALAQLEAEKREVERSALRLE 1872
Q E R R+E E K + RL LQ + Q++LAQ EAEK++ E
Sbjct: 1584 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA------ 1637
Query: 1873 KDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV- 1931
+R A RR K E + +R E AE EL E QRQ+ + AQ
Sbjct: 1638 -EREARRR--GKAEEQAVRQREL-----------------AEQEL-EKQRQLAEGTAQQR 1676
Query: 1932 VVLEQSHSPAQLEVDAQQQQLE-LQQEVERL-RSAQAQTERTLEARERAHRQRVRGLEEQ 1989
+ EQ + E + +QQ + L++E+ RL R A A T++ E A +VR E
Sbjct: 1677 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL--EAELAKVRAEMEV 1734
Query: 1990 VSTLKGQLQQELRRSS 2005
+ K + ++E R +S
Sbjct: 1735 LLASKARAEEESRSTS 1750
Score = 48.9 bits (115), Expect = 5e-05
Identities = 48/216 (22%), Positives = 98/216 (45%), Gaps = 17/216 (7%)
Query: 5 LARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPES 64
LA ++V L IQ +S + +L ++ + A + ++ + + +
Sbjct: 2390 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2449
Query: 65 PVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRL 124
LL T+ L E++ LLQ+ E + Q +A+ ++L A +++L + +
Sbjct: 2450 EQLLQETQALQQSFLSEKDSLLQR-----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2504
Query: 125 EPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYK 184
+ ++E QE + LV E RR+ E + RRK + Q+ +Q++ Q + L
Sbjct: 2505 QQQQME-QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL-------- 2555
Query: 185 KRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI 220
+E Q+L E+ LE+Q HS+++ ++ +
Sbjct: 2556 ---AEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2588
Score = 35.4 bits (80), Expect = 0.57
Identities = 89/418 (21%), Positives = 174/418 (41%), Gaps = 43/418 (10%)
Query: 1606 ERSLQATESELRASQEKISKMKANETKL-EGDKRRLKEVLDASESRTVKLELQ------R 1658
ER ++ E+ + K K E E DK R K + + E +L+
Sbjct: 272 ERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP 331
Query: 1659 RSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVE 1718
+E E + + + +RE Q ++ +R++ LQR V +++AG L E+LN
Sbjct: 332 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG---LCEEQLN------- 381
Query: 1719 ESEGALRDKVRGLTEA-LAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQAL 1777
+++ L+ VR L + Q + + DK + + L +D Q L+ D
Sbjct: 382 QADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF---NDVQTLK---DGRHPQG 435
Query: 1778 SEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQ 1837
+ ++ L E++ +R E +L L+ A Q + L+ Q +T++ LQ
Sbjct: 436 EQMYRRVYRLHERLVAIRTEY-NLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ 494
Query: 1838 DERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV 1897
D ++E + A ++ E + + R L +++++ + R+ D
Sbjct: 495 DLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR------GLHQSIEEFRAKIERARSDEG 548
Query: 1898 RLS-AEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL-Q 1955
+LS A +G L +L+ A + + +A++ LE HS A ++ + L +
Sbjct: 549 QLSPATRGAYRDCLGRLDLQYA---KLLNSSKARLRSLESLHS---FVAAATKELMWLNE 602
Query: 1956 QEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQ---QELRRSSAPFSP 2010
+E E + + + A++ ++ +R LE + +K +LQ L R P P
Sbjct: 603 KEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK-ELQNAGDRLLREDHPARP 659
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 266 bits (680), Expect = 2e-70
Identities = 459/1955 (23%), Positives = 813/1955 (41%), Gaps = 297/1955 (15%)
Query: 110 KYNAVSERLEQALR-LEPGELETQEPRGLVRQSVELRRQLQ--EEQASYRRKL------- 159
+Y + S +Q L+ LE G E + + + ++R QL+ E + +R +L
Sbjct: 1094 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA 1153
Query: 160 ----QAYQEGQQRQAQL------VQRLQG---KILQYKK---RCSELEQQLLERSGELEQ 203
Q E Q+ QA++ V RL K+L + L +L G+LEQ
Sbjct: 1154 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1213
Query: 204 QR----------------LRDTEHSQD-LESALIRLEEEQQRSASLAQVNAM------LR 240
R +R T+ +++ L + +L+E Q A+L ++ A LR
Sbjct: 1214 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1273
Query: 241 EQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLW 300
Q + AL +++R R ++ R+ R E ++LL W
Sbjct: 1274 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERV--------AQLLERW 1325
Query: 301 RQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAES-RAEAALEK 359
+ V+ ++V+ +R+L QLG +L + G L R E +A +
Sbjct: 1326 QAVLA----QTDVR---QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1378
Query: 360 QALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQV 419
QA+ + +EQ + + ++ Q + + + EL L + + + +
Sbjct: 1379 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK 1438
Query: 420 NKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADA 479
+ E++ +QE L T E T +Q + SE+ ++ ER A+
Sbjct: 1439 KPKVQSGSESV----IQEYVDLRTHYSELTTLT----SQYIKFISETLRRMEEEERLAEQ 1490
Query: 480 SNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMR 539
QR R + +R + A + + A + ++++Q + +R
Sbjct: 1491 ----------QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540
Query: 540 GRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANE 599
R EA+ D ++ ++R+++E+LQ+LR ++ +QA + R A E
Sbjct: 1541 -REEAAVD-----------AQQQKRSIQEELQQLRQSSEAEIQA---------KARQA-E 1578
Query: 600 LLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
R + + ++V + Q E ++R + + LR + + E ++ A ++ R+RR
Sbjct: 1579 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1638
Query: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRA--TLQRDMLQAEKAEVAEALTKAEAGR 717
+++ ++ Q E + + K E RA L+ LQAE+AE + E R
Sbjct: 1639 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1698
Query: 718 VELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAE 777
T R+ EA LQ + + L + + + VAQL EE R+ Q +
Sbjct: 1699 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE----RRAQQQ 1754
Query: 778 QEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLA 837
EA AREE ER EL Q A + L L+ E AQ Q+ LA
Sbjct: 1755 AEAERAREEAER--ELERWQLKANEALRLRLQAEEVAQ-----------------QKSLA 1795
Query: 838 QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKE-------HAGLAVQLVAAER 890
Q E++ E+A REA+R+ +A E+A R++E +E G A Q +AAE+
Sbjct: 1796 QAEA-----EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1850
Query: 891 EGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAG 950
E L E + +++ LE L +QR+ A +R++LEAE + E L A
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1910
Query: 951 LRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELE 1010
++ +T EK+ E A + + EA R + A E QR E++AA + E
Sbjct: 1911 AEEESRSTSEKSKQRLEAEAGRFRELAEEAA---RLRALAEEAKRQRQLAEEDAARQRAE 1967
Query: 1011 AERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLL--LAESEKQQALSLKE 1068
AER E+L A EA + + EIA ++E + L LAE E Q L+E
Sbjct: 1968 AERVLA--------EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 2019
Query: 1069 S---EKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQRE 1125
K + E+L R + + E+ERQK + Q R + E+ L+A E
Sbjct: 2020 QAAQHKADIEERLAQLRKASDS---ELERQKGLVEDTLRQRRQ----VEEEILALKASFE 2072
Query: 1126 EAAAAHAQ---EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
+AAA A+ E+ R++ A D + ++ EA R QL E+ R RRE E +
Sbjct: 2073 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-QLAAEEERR---RREAEERVQ 2128
Query: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERI-SLKLANE 1241
K ++E QR+ A E E E L+ EE R ++AE E L+LA E
Sbjct: 2129 KSLAAEEEAARQRKAALE----------EVERLKAKVEEARRLRERAEQESARQLQLAQE 2178
Query: 1242 DKEQKLALLEEART-AVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLG 1300
+++L E+A AV ++ EL+ LQ+ + + R E + RR + + +
Sbjct: 2179 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2238
Query: 1301 RELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQEL-QVAQRKLQEQEGEF 1359
RE A+ + ++ ER ++ + + Q + +A+ E +R+E Q A R+ Q ++
Sbjct: 2239 REAAQSRRQVEEAERLKQSAEEQA----QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2294
Query: 1360 RTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAEL 1419
R ++ +E+ + +Q L +E +L R L+L + + L+ EL
Sbjct: 2295 RQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR-------LQLEETDHQKNLLDEEL 2346
Query: 1420 ARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPST 1479
R++ + A Q RS + L R
Sbjct: 2347 QRLKAEATEAARQ----RSQVEEELFSVR------------------------------- 2371
Query: 1480 LECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRE--RDELRTQTSALNR 1537
++ S+ + A + A D + + L+E ++++ E R + Q +A R
Sbjct: 2372 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2431
Query: 1538 QLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRA 1597
QLAE + + A + +K A E R + L Q ELA +E RR + ++
Sbjct: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA--QEQARRLQEDKEQ 2489
Query: 1598 TLDQVATLERSLQAT-------ESELRASQEK----ISKMKANETKLEGDKRRLKEVLDA 1646
Q+A + Q T + E+ A E+ +++M + + E D +R ++ +
Sbjct: 2490 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2549
Query: 1647 SESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLT 1706
+ + EL + +Q + + A+ L++ + L+R+ + +A LQL
Sbjct: 2550 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL- 2608
Query: 1707 VERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNST---RDKNLHLQKALTACEHDR 1763
K EE + ++++ T+AL QS S + R++ + +KA
Sbjct: 2609 ---------KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL-----E 2654
Query: 1764 QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQ 1823
Q+ Q+ + A+Q E ++Q + ++ Q L VA +E EA + + E +R++Q
Sbjct: 2655 QLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASME----EARRRQHEAEEGVRRKQ 2707
Query: 1824 EGEAAALNTVQKLQDERR----LLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALR 1879
E +Q+L+ +RR LL E L+ L LE + R + + +VA
Sbjct: 2708 E-------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2760
Query: 1880 RTLDK---------VEREKLRSHEDTVR-LSAEKGRLDRTLTGAELE-LAEAQRQIQQLE 1928
+TL E E S + R +SA++ + L+ EL+ LA+ + +L
Sbjct: 2761 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2820
Query: 1929 AQVVV---LEQSHSPAQLEVDAQQQQLELQQEVER 1960
+ V L+ S A L + A ++L + ++R
Sbjct: 2821 RREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQR 2855
Score = 263 bits (673), Expect = 1e-69
Identities = 357/1544 (23%), Positives = 644/1544 (41%), Gaps = 172/1544 (11%)
Query: 543 EASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRS-ANELL 601
EA++ L LR Q + AL ++L+ ++ + Q H + EV+R R +LL
Sbjct: 1263 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1322
Query: 602 SREKSNLAHSLQVAQQQAEEL----RQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARV 657
R ++ LA + V Q++ E+L R RE L+ R R E+ Q + D V
Sbjct: 1323 ERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1381
Query: 658 RRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGR 717
R +L + LE++E EK E + K
Sbjct: 1382 REQLRQEQALLEEIER--------------------------HGEKVEECQRFAKQYINA 1415
Query: 718 V---ELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQL-----------E 763
+ EL+L K + E + K+ + +ES+ Q+ +DL ++L
Sbjct: 1416 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1475
Query: 764 EEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLP 823
E ++ +R AEQ+ EE+ERL E+ E RQ E + QA+ ++
Sbjct: 1476 ETLRRMEEEERLAEQQRA---EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1532
Query: 824 TLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEA----LERAAREKEALAKEHA 879
++ E + +E +Q ++EL+Q R+ ++ +++A E A R + + +E
Sbjct: 1533 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1592
Query: 880 GLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEAR---REQLEAEGQA 936
+ +QL A ER+ E LR E E + Q + +L + Q + + +
Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1652
Query: 937 LLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAE---------------REAQ 981
L ++ E A +Q+ + E+ L E ++L QAE R A+
Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712
Query: 982 ASLREQRAAHEEDLQRLQREKE------AAWRELEAERAQLQSQLQREQEELLARLEA-- 1033
A L+ +RA+ E +L+R + A RE RAQ Q++ +R +EE LE
Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1772
Query: 1034 --EKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE 1091
E L + A + + + L AE+EKQ+ + +E+ + +E+ + LA LE
Sbjct: 1773 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1832
Query: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHA---QEVRRLQEQARDLGKQ 1148
+RQ + ++Q A EL LRA+ E+ +E+ RLQ +A ++
Sbjct: 1833 KQRQLAEGTAQQRL------AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1886
Query: 1149 RDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLR---ESQEGREVQRQEAGELRRSL 1205
R E ++R ++ +L ++ E K + E++ GR + E R+L
Sbjct: 1887 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1946
Query: 1206 GEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELR 1265
E AK + L + +A ++AE+ER+ +KLA + EA K E+
Sbjct: 1947 AEEAKRQRQLAEED----AARQRAEAERVLA--------EKLAAIGEATRL--KTEAEIA 1992
Query: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETL 1325
+E E RL RR ++ Q + L+ + + A+++ RLA +A
Sbjct: 1993 LKEKEAENERL--RRLAEDEAFQRRRLEEQ---AAQHKADIEERLAQLRKASDSELERQK 2047
Query: 1326 GLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA-RGTEKQQLDHA 1384
GL + L+ +E L+ + K + E R+ + E+ R E+ +L+ A
Sbjct: 2048 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 2107
Query: 1385 RGLELKLEAARA--EAAE-LGLRLSAAEGRAQGLEAELARVE-VQRRAAEAQLGGLRSAL 1440
R +L E R EA E + L+A E A+ +A L VE ++ + EA+ R+
Sbjct: 2108 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2167
Query: 1441 RRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASP 1500
L A A + + A A E TL+ G A
Sbjct: 2168 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ-ELQQTLQQEQSVLDQLRGEA------ 2220
Query: 1501 DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNR--QLAEMEAERDSATSRARQLQK 1558
EA R A E + A+RE + R Q R Q AE +A+ + A + +
Sbjct: 2221 ----EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2276
Query: 1559 AVAESEEARRSVDGRLS-----GVQAELALQEESVRRSERERRATLDQVATLERSLQATE 1613
AE E ARR+ + + AE+ ++ ++ R++ ++ TL L+ T+
Sbjct: 2277 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2336
Query: 1614 SELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLS 1673
+ E++ ++KA T+ + +++E L + + +L + +E E L L
Sbjct: 2337 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE--NRALILR 2394
Query: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGA----LAKVEE-SEGALRDKV 1728
D++ + LQ+ + + +QVA+ + RL LA+ +E L++K+
Sbjct: 2395 DKDNTQRFLQEEAEKM-KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2453
Query: 1729 RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQ---ERLDAARQALSEARKQSS 1785
+ + EA + + + K L ++A E Q+ Q E ++ L R++
Sbjct: 2454 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2513
Query: 1786 SLGEQVQTLRGEVADLELQRVEAEGQLQQLR-------EVLRQRQEGEAAALNTVQKLQD 1838
+ + + L+ VA++ + AE Q+ R E L + + + VQ L+
Sbjct: 2514 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2573
Query: 1839 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR 1898
+R+ L+ A+A+LE EK ++++ A L+ + V++E+L
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQ------ 2623
Query: 1899 LSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV 1958
E L ++ + L + +R I+Q +A++ L Q ++ +QQ+ + Q E
Sbjct: 2624 ---ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680
Query: 1959 ERLRSAQAQTERTLEARERAH--RQRVRGLEEQVSTLKGQLQQE 2000
ER R + EAR R H + VR +E++ L+ Q +Q+
Sbjct: 2681 ERQRLVASME----EARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2720
Score = 234 bits (597), Expect = 6e-61
Identities = 425/1785 (23%), Positives = 742/1785 (41%), Gaps = 230/1785 (12%)
Query: 116 ERLEQALRLEPGELETQEP-----RGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQA 170
E + +L+ + E Q+P R +R + E+ +LQ+ +++ ++E R A
Sbjct: 1263 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE---RVA 1319
Query: 171 QLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI---RLEEEQQ 227
QL++R Q + Q R ELEQ ++LR S D A + R +EQ
Sbjct: 1320 QLLERWQAVLAQTDVRQRELEQL---------GRQLRYYRESADPLGAWLQDARRRQEQI 1370
Query: 228 RSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCR----------KELEHREAA 277
++ LA A+ REQL Q QAL E+I + C+ K+ E +
Sbjct: 1371 QAMPLADSQAV-REQLRQ----EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1425
Query: 278 WRRE-----------------EESFNAYFS--NEHSRLLLLWRQVVGFRRLVSEV--KMF 316
++ + E Y +S L L Q + F +SE +M
Sbjct: 1426 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF---ISETLRRME 1482
Query: 317 TERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVL 376
E L + R A EA L L A ++A+A E++A +L+++++++V+
Sbjct: 1483 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA---KELQQRMQEEVV 1539
Query: 377 REKDLA---QQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL 433
R ++ A QQQ +S ++ + +E + K + + E+ ++ + E + +
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE-----EEIRVV 1594
Query: 434 RLQEQAALETEDG-EGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRT 492
RLQ +A G EG Q LR A+ E+ Q ++ A+ ++ S ++
Sbjct: 1595 RLQLEATERQRGGAEGELQALRARAE------EAEAQKRQAQEEAERLRRQVQDESQRKR 1648
Query: 493 PSPPRRSSPGRGRSPR-RGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGT 551
+ +S + + R A L L +R Q + R R + L
Sbjct: 1649 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQVALETA 1707
Query: 552 LRKQLSDSESERRALEE---QLQR-LRDKTDGAMQAHEDAQREVQR---LRSANELLSRE 604
R ++ +S+R + E QL+R L+++ Q E+A+R Q+ A E RE
Sbjct: 1708 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1767
Query: 605 ------KSNLAHSLQVAQQQAEELRQEREKLQAA----QEELRRQRDRLEEEQEDAVQDG 654
K+N A L++ QAEE+ Q++ QA +EE R+ R + +E AV+
Sbjct: 1768 LERWQLKANEALRLRL---QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1824
Query: 655 ARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE 714
+ELE+ + E +R +EL+ +R + QR +L+ E A + A
Sbjct: 1825 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1884
Query: 715 AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQ------LEEEKSA 768
R ELE + K+RAE L SK A ES + + RL A+ L EE +
Sbjct: 1885 QKRQELEAELAKVRAEMEVLL--ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1942
Query: 769 LQG------RQRQ-AEQEATVAREEQERL--EELRLEQEVARQGLEG--SLRVAEQAQEA 817
L+ RQRQ AE++A R E ER+ E+L E R E +L+ E E
Sbjct: 1943 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 2002
Query: 818 LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR-REAQRQVEALERAAREKEALAK 876
L + +R +L+EQ AQ + R +L +A E +RQ +E R++ + +
Sbjct: 2003 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 2062
Query: 877 EHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARRE-QLEAEGQ 935
E L A L E R+R E S ++ A+LEA R+ QL AE
Sbjct: 2063 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRS-----KEQAELEAARQRQLAAE-- 2115
Query: 936 ALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL 995
+E E Q+ +A +E+A+ ++ +++ + + + + + R + A +E
Sbjct: 2116 -----EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2170
Query: 996 QRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLL 1055
++LQ +EAA + L+AE +Q++++EL ++ L +E + L Q R E
Sbjct: 2171 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL-------QQTLQQEQSVLDQLRGE---- 2219
Query: 1056 AESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTS 1115
AE+ ++ A +E+ A E R E ER K+ A+ Q Q R+ A
Sbjct: 2220 AEAARRAAEEAEEARVQAEREAAQSRRQVE-----EAERLKQSAEE-QAQARAQAQAAAE 2273
Query: 1116 ELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRR 1175
+LR A++E A A A++ Q+QA D ++ + AE+ Q +E LR
Sbjct: 2274 KLRK-EAEQEAARRAQAEQAALRQKQAADAEMEKHK--KFAEQTLRQKAQVEQELTTLRL 2330
Query: 1176 ELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERIS 1235
+L E + E + + EA E R + +E ++R EEL + E+E +
Sbjct: 2331 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2390
Query: 1236 LKLANEDKEQKLALLEEARTA--VGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLD 1293
L L ++D Q+ L EEA V +EA L QE R R A +L + R + +
Sbjct: 2391 LILRDKDNTQRF-LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2449
Query: 1294 SENTRLGRELAELQGRLAL----GERAEKESRR--------------ETLGL-------R 1328
E + +E L+ L E A++++RR ET G R
Sbjct: 2450 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2509
Query: 1329 QRLLKGEASLEVMR---QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHAR 1385
QR L+ A E ++ E+ AQ + +E FR + + L ++++ +
Sbjct: 2510 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2569
Query: 1386 GLELKLEAARAEAAELGLRLSAAEGRAQGLEAE-----LARVEVQRRAAEAQLGGLRSAL 1440
LE++ + + +A L ++ E + L+ E L E+Q E L ++
Sbjct: 2570 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2629
Query: 1441 RRGLGLGRAPSPAPRPVPGSPAR------DAPAEGSGEGLNSPSTLECSPGSQPPSPGPA 1494
+ L + R + A+ D A+ + L + Q A
Sbjct: 2630 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK--AQQLREEQQRQQQQMEQERQRLVA 2687
Query: 1495 TSPASPDLDPEAVRGALR--EFLQELRSAQRERDE-LRTQTSALNRQLAEMEAERDSATS 1551
+ + EA G R E LQ+L +R+++E L + L QL +E + +A +
Sbjct: 2688 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2747
Query: 1552 RARQLQKAVAESEEARRSVDGRLSGVQAELALQE--ESVRR---SERERRATLDQVATLE 1606
+ ++ + + + + L G AE + + +RR ++R + A + L+
Sbjct: 2748 HSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2807
Query: 1607 RSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDA-SESRTVKLELQRRSLEGEL 1665
R Q + +++++ + L+G +L A +E +V LQR+ L
Sbjct: 2808 RLAQG-----HTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS--- 2859
Query: 1666 QRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR 1725
+ L L + +A + L D V + +R + VK G + L+ L E + +
Sbjct: 2860 PGTALILLEAQAASGFLLDPVRN-RRLTVNEAVKEGVVG---PELHHKLLSAERAVTGYK 2915
Query: 1726 DKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERL 1770
D G +L Q+ +QK L EH ++L+ ++
Sbjct: 2916 DPYTGQQISLFQA-------------MQKGLIVREHGIRLLEAQI 2947
Score = 220 bits (560), Expect = 1e-56
Identities = 342/1419 (24%), Positives = 607/1419 (42%), Gaps = 206/1419 (14%)
Query: 75 SLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEP 134
+L ++EE +L +Q+ + + LA+ A ++ A ++ QA R E EL+ +
Sbjct: 1477 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER-EAKELQQRMQ 1535
Query: 135 RGLVRQ------SVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQR------------- 175
+VR+ + + +R +QEE R+ +A + + RQA+ +R
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1595
Query: 176 ------------LQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLE 223
+G++ + R E E Q + E E+ R + + SQ A + L
Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1655
Query: 224 EEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTR-CRKELEHREAAWRREE 282
+ A A+ + L++ + +R+ + R + LE + + E
Sbjct: 1656 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1715
Query: 283 ESFNAYFSNEHSRL-LLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR--TSRAVQEAG 339
+S A F+ + ++L L + V +L E + ++ Q E AR R ++
Sbjct: 1716 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ---QAEAERAREEAERELERWQ 1772
Query: 340 LGLSTGLRLAESRAEAALEKQALLQAQLEEQ-------------LRDKVLREKDLAQQQM 386
L + LRL +AE ++++L QA+ E+Q ++ +R+++LA+Q++
Sbjct: 1773 LKANEALRL-RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1831
Query: 387 QSDLDKADLSARVTELGLAVK----RLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALE 442
+ A+ +A+ LA + RL + + +Q + L E+L RLQ +AA
Sbjct: 1832 EKQRQLAEGTAQQR---LAAEQELIRLRAETEQGEQQRQLLEEELA-----RLQREAAAA 1883
Query: 443 TEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPG 502
T+ + L+ L + +E V L+ R + S S S QR + G
Sbjct: 1884 TQKRQELEAELAKVR------AEMEVLLASKARAEEESR-STSEKSKQRL-----EAEAG 1931
Query: 503 RGRSPRRGPSPACSDSSTL-ALIHSALHKRQLQVQDM-RGRYEASQDLLG---------- 550
R R +++ L AL A +RQL +D R R EA + L
Sbjct: 1932 RFRE-------LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1984
Query: 551 -------TLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANEL-LS 602
L+++ +++E RR E++ + R + A Q D + + +LR A++ L
Sbjct: 1985 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 2044
Query: 603 REKSNLAHSLQVAQQQAEE---LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
R+K + +L+ +Q EE L+ EK A + EL + R+ ED ++ +
Sbjct: 2045 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 2104
Query: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVE 719
E R RQL E +R A+E V+ A ++ E+ E +A K E R
Sbjct: 2105 EAARQ-RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA--KVEEAR-- 2159
Query: 720 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQE 779
R E + Q+S +L E+ AQ +L Q EE+ A +Q++ E +
Sbjct: 2160 --------RLRERAEQESARQLQLAQEA-AQKRL-------QAEEKAHAFAVQQKEQELQ 2203
Query: 780 ATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ-EALEQQLPTLRHER-SQLQEQLA 837
T+ ++EQ L++LR E E AR+ E + QA+ EA + + ER Q E+ A
Sbjct: 2204 QTL-QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262
Query: 838 QLSRQLSGREQEL-EQARREAQRQVEALERAAREKEA---------------------LA 875
Q Q ++L ++A +EA R+ +A + A R+K+A +
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2322
Query: 876 KEHAGLAVQLVAAEREGRTLSEEATRLRLE-------KEALEGSLFEVQRQLAQLEARRE 928
+E L +QL + + L EE RL+ E + +E LF V+ Q+ +L +
Sbjct: 2323 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2382
Query: 929 QLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQR 988
++EAE +AL+L + T + + + + + AQ+ + + A+ L +QR
Sbjct: 2383 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR 2442
Query: 989 AAHEEDL-QRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQ 1047
A E+ L +++Q +EA + EAE Q Q +L +EQ RL+ +KE++++++A Q
Sbjct: 2443 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR---RLQEDKEQMAQQLAEETQ 2499
Query: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDR 1107
L E+E+Q+ L E +A +E+L + +A +S R + DAQ ++Q
Sbjct: 2500 GFQRTL---EAERQRQL-----EMSAEAERL---KLRVAEMSRAQARAEEDAQRFRKQAE 2548
Query: 1108 STVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLE 1167
L R A +E+ E++R Q +AE LR + LE
Sbjct: 2549 EIGEKLH---RTELATQEKVTLVQTLEIQRQQSD------------HDAERLREAIAELE 2593
Query: 1168 DARDGLRRELLEAQRKLRESQEGREVQ-RQEAGELRRS-LGEGAKEREALRRSNEELRSA 1225
++ L++E Q K E Q ++ Q QE L++S L E + R +E
Sbjct: 2594 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2653
Query: 1226 VKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQEL 1285
+ + E + E+++++ +E+ R + E R E E + ELQ+L
Sbjct: 2654 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2713
Query: 1286 ----RRQMKMLDSENTRLGR--ELAELQGRLALGE----RAEKESRRETLGLRQRLLKGE 1335
R+Q ++L EN RL +L E Q R AL A + + +TL + L G
Sbjct: 2714 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGP 2773
Query: 1336 ASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEAR 1374
A+ +RK+ Q R +E +L + E R
Sbjct: 2774 AAEAEPEHSFDGLRRKVSAQ----RLQEAGILSAEELQR 2808
Score = 195 bits (496), Expect = 3e-49
Identities = 323/1344 (24%), Positives = 558/1344 (41%), Gaps = 216/1344 (16%)
Query: 746 ESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV------AREEQERL-EELRLEQE 798
E AQ++ R +++L++ + L+ + + + ARE +R+ E+ + + E
Sbjct: 1110 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE 1169
Query: 799 VARQGLEGSLRVAEQAQE--ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE 856
V G +G R++ +A++ AL + P RS+L+ L +L + S L E
Sbjct: 1170 VEGLG-KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS-----LSAIYLE 1223
Query: 857 AQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEV 916
+ + + R + E + + H EE + E +A+ +L E+
Sbjct: 1224 KLKTISLVIRGTQGAEEVLRAH------------------EEQLK---EAQAVPATLPEL 1262
Query: 917 QRQLAQLEARREQLEAEGQALLLAKETLTG-ELAGLRQQIIATQEKASLDKELMAQKLVQ 975
+ A L+ R Q EA+ ++ L G + G R Q Q D E+ +
Sbjct: 1263 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ----QRHGERDVEVERWR--- 1315
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQ------SQLQREQEEL-- 1027
ER AQ R Q + D++ QRE E R+L R +R QE++
Sbjct: 1316 -ERVAQLLERWQAVLAQTDVR--QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1372
Query: 1028 --LARLEAEKEELSEEIAALQQERDEGLLLAESE---KQQALSLKESEKTALSEKLMGTR 1082
LA +A +E+L +E A L++ G + E + KQ ++K+ E
Sbjct: 1373 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL----------- 1421
Query: 1083 HSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQA 1142
L T ++E A+ + Q S ++ E DLR E +Q ++ + E
Sbjct: 1422 -QLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1478
Query: 1143 RDLGKQRDSCLREAEELRTQLRLLEDARDGLR--------------RELLEAQRKLRESQ 1188
R + ++ ++ E R +L +E A + R RE E Q++++E
Sbjct: 1479 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1538
Query: 1189 EGREVQRQEAGELRRSLGEGAKEREALRRSNE-ELRSAVKKAES-ERISLKLANEDKEQK 1246
RE +A + +RS+ E E + LR+S+E E+++ ++AE+ ER L++ E + +
Sbjct: 1539 VRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1595
Query: 1247 LAL--LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELA 1304
L L E R E LR +E E + +A+ E + LRRQ++ E+ R +
Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQRKRQAEV 1652
Query: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER 1364
EL R+ +AE E+ RE +QR L+ +LE +R + + A+R+L++ E E R R
Sbjct: 1653 ELASRV----KAEAEAARE----KQRALQ---ALEELRLQAEEAERRLRQAEVE---RAR 1698
Query: 1365 RLLGSLEEARGTEKQQLDHARG--------LELKLEAARAEAAELGLRLSAAEGRAQGLE 1416
++ +LE A+ + + +L R LE L+ A+L R A Q E
Sbjct: 1699 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL--REEAERRAQQQAE 1756
Query: 1417 AELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNS 1476
AE AR E +R QL ALR L A A AE E
Sbjct: 1757 AERAREEAERELERWQLKA-NEALRLRL-------QAEEVAQQKSLAQAEAEKQKEEAER 1808
Query: 1477 PSTLECSPGSQPPSPGPATSPASPDLDPEA--VRGALREFL---QELRSAQRERDELRTQ 1531
+ G A +L+ + G ++ L QEL + E ++ Q
Sbjct: 1809 EARRR---GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1865
Query: 1532 TSALNRQLAEMEAERDSATSRARQLQKAVAE---------SEEARRSVDGRLSGVQAELA 1582
L +LA ++ E +AT + ++L+ +A+ + +AR + R + +++
Sbjct: 1866 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1925
Query: 1583 LQEESVR-RSERERRATLDQVAT-LERSLQATESELRASQEKISKMKANETKLEGDKRRL 1640
L+ E+ R R E A L +A +R Q E + + + ++ A + G+ RL
Sbjct: 1926 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1985
Query: 1641 KE----VLDASESRTVKLE-------LQRRSLEGELQRSRLGLSDREAQAQALQDR---- 1685
K L E+ +L QRR LE + + + + +R AQ + D
Sbjct: 1986 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 2045
Query: 1686 ----VDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSAS 1741
V+ RQ E + L+ + E+ A++E G +R + Q A
Sbjct: 2046 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ--AE 2103
Query: 1742 LNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADL 1801
L + R + L ++ E R+ +ER+ + A EA +Q + E+V+ L+ +V +
Sbjct: 2104 LEAARQRQLAAEE-----ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158
Query: 1802 ELQRVEAEG----QLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQL 1857
R AE QLQ +E ++R + E A +Q + + LQ+ L Q L QL
Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQKRLQAEEKA--HAFAVQQKEQELQQTLQQEQSVLDQL 2216
Query: 1858 EAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELEL 1917
E R+A E+ RV + ERE +S ++
Sbjct: 2217 RGEAEAARRAAEEAEEARV-------QAEREAAQSRR---------------------QV 2248
Query: 1918 AEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARER 1977
EA+R Q E EQ+ + AQ + A++ + E +QE R A+ R +A +
Sbjct: 2249 EEAERLKQSAE------EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD- 2301
Query: 1978 AHRQRVRGLEEQVSTLKGQLQQEL 2001
A ++ + EQ K Q++QEL
Sbjct: 2302 AEMEKHKKFAEQTLRQKAQVEQEL 2325
Score = 188 bits (477), Expect = 5e-47
Identities = 438/1879 (23%), Positives = 754/1879 (40%), Gaps = 272/1879 (14%)
Query: 271 LEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR 330
+ H AA+ EE F + F + +LW Q + F+ + K E D + G
Sbjct: 432 MRHHTAAF--EERRFPSSFEE----IEILWSQFLKFKEMELPAK---EADKNRSKGIYQS 482
Query: 331 TSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLR----EKDLAQQQM 386
AVQ L + G + E A+L+ E+QLR + R ++ + + QM
Sbjct: 483 LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILER--EKQLRSEFERLECLQRIVTKLQM 540
Query: 387 QSDLDKADLSARVTELGLAVKRLEKQNLEK--DQVNKDLTEKLEALESLRLQEQAALETE 444
++ L + L+ L V+ L + + +V +DL +K +++ L +
Sbjct: 541 EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL-DKADSMIRLLFNDV------ 593
Query: 445 DGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRG 504
QTL+D V A + +LR +G +P + +
Sbjct: 594 ------QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG--VAAPATQVAQVTL 645
Query: 505 RSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERR 564
+S +R P + STL + L V++ + R + ++ G + R
Sbjct: 646 QSVQRRPE---LEDSTLRYLQDLL----AWVEENQHRVDGAE--WGVDLPSVEAQLGSHR 696
Query: 565 ALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQ 624
L + ++ R K + A ++ Q + + L R A L ++ + L
Sbjct: 697 GLHQSIEEFRAKIERARS--DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 754
Query: 625 EREKLQAAQEELRRQRDRLEEE-----------QEDAVQDGARVRRELERSHRQLEQLEG 673
+ AA +EL ++ EEE + + + RELE +++++L+
Sbjct: 755 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 814
Query: 674 KRSVLAKELVEVREALS--RATLQRD---MLQAEKAEVAEALTKAEAGRVELELSMTKLR 728
L +E R + +A LQ MLQ EA K A + + +
Sbjct: 815 AGDRLLREDHPARPTVESFQAALQTQWSWMLQL--CCCIEAHLKENAAYFQFFSDVREAE 872
Query: 729 AEEASLQDSLSKLSALNESLAQDKL-----DLNRLVAQLEEEKSALQGRQRQAEQEATVA 783
+ LQ++L + + + S +L D QL E K L G ++A+ A V
Sbjct: 873 GQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK--AVVQ 930
Query: 784 REEQERLEELR----LEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQ-LAQ 838
+ + +R L + +E ++ ++ Q Q + S E +
Sbjct: 931 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 990
Query: 839 LSRQLSGREQELEQARREAQRQVEALERAARE-----KEALAKEHAGLAVQLVAAEREG- 892
+ + QE ++A + Q +AL + K LA + VQL+ +
Sbjct: 991 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT 1050
Query: 893 -RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 951
RTL E R L L F Q A ++L AE + G +
Sbjct: 1051 FRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREY---------GSCSHH 1101
Query: 952 RQQIIATQEKASLDKELMAQKLVQAEREAQASLR--EQRAAHEEDLQRLQRE--KEAAWR 1007
QQ++ + E+ + +E Q+ + ++ + L E R H L L +E +E A R
Sbjct: 1102 YQQLLQSLEQGA-QEESRCQRCISELKDIRLQLEACETRTVHRLRLP-LDKEPARECAQR 1159
Query: 1008 ELEAERAQLQ--------SQLQREQEELLARLEAE------KEELSEEIAALQQERDEGL 1053
E ++AQ + ++L E E++LA E + EL + L+Q R
Sbjct: 1160 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1219
Query: 1054 LLAESEKQQALSLK-----ESEKTALSEKLMGTRHSLATISLEMERQK---RDAQSRQEQ 1105
+ E K +L ++ E A E+L + AT+ E+E K + +++ E
Sbjct: 1220 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEA 1278
Query: 1106 DRSTVNALTSELRDLRAQREEAAAAHAQ---EVRRLQEQARDLGK-------QRDSCLRE 1155
+ T +AL ELR + E H + EV R +E+ L + Q D RE
Sbjct: 1279 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRE 1338
Query: 1156 AEELRTQLRLLEDARDGLRRELLEAQRK--------LRESQEGREVQRQEAGELRRSLGE 1207
E+L QLR ++ D L L +A+R+ L +SQ RE RQE L
Sbjct: 1339 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERH 1398
Query: 1208 GAKEREALRRSNEELRSAVKKAESERISLKLANED--KEQKLALLEEARTAVGKEAGELR 1265
G K E R + + + +A+K E + ++ K E K ++ +V +E +LR
Sbjct: 1399 GEKVEECQRFAKQYI-NAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1457
Query: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLG-RELAELQGRLALGERAEKESRRET 1324
T E+ + + + E R+M+ E RL ++ AE + RLA E A ++ R+
Sbjct: 1458 THYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLA 1513
Query: 1325 LGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHA 1384
Q + E + ++Q +Q + +E + + ++R S++E E QQL +
Sbjct: 1514 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR----SIQE----ELQQLRQS 1565
Query: 1385 RGLELKLEAARAEAAELG-LRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRG 1443
E++ +A +AEAAE LR+ E + + +L E QR AE +L LR+
Sbjct: 1566 SEAEIQAKARQAEAAERSRLRI---EEEIRVVRLQLEATERQRGGAEGELQALRARAEE- 1621
Query: 1444 LGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLD 1503
+ A+ A+ E L + SQ + +
Sbjct: 1622 ----------------AEAQKRQAQEEAERLRR----QVQDESQRKRQAEVELASRVKAE 1661
Query: 1504 PEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAES 1563
EA R E + A + +ELR Q R+L + E ER ARQ+Q A+
Sbjct: 1662 AEAAR--------EKQRALQALEELRLQAEEAERRLRQAEVER------ARQVQVAL--- 1704
Query: 1564 EEARRSVDGRLSG---------VQAELALQEESVR----RSERERRATLDQVATLERSLQ 1610
E A+RS + L Q E +LQEE V R E ERRA Q A ER+ +
Sbjct: 1705 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA--QQQAEAERARE 1762
Query: 1611 ATESELR-------------------ASQEKISKMKANETKLEGD---KRRLKEVLDASE 1648
E EL A Q+ +++ +A + K E + +RR K A
Sbjct: 1763 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1822
Query: 1649 SRTV---KLELQRRSLEG----------ELQRSRLGLSDREAQAQALQDRVDSLQRQVAD 1695
R + +LE QR+ EG EL R R E Q Q L++ + LQR+ A
Sbjct: 1823 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1882
Query: 1696 SEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE----ALAQSSASLNSTRDKNLH 1751
+ K L+ + ++ + + S+ ++ R +E L + ++
Sbjct: 1883 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1942
Query: 1752 LQKALTACEHDRQVLQERLDAARQALSEAR---KQSSSLGEQVQTLRGEVADLELQRVEA 1808
L+ + RQ+ +E DAARQ R ++ +++GE + L+ E A++ L+ EA
Sbjct: 1943 LRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATR-LKTE-AEIALKEKEA 1998
Query: 1809 EGQLQQLREVLRQRQEGEAAALNTVQKLQDERRL-LQERLGSLQRAL-AQLEAEKREVE- 1865
E E LR+ E EA +++ + + ++ERL L++A ++LE +K VE
Sbjct: 1999 E------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 2052
Query: 1866 --RSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQ 1923
R ++E++ +AL+ + +K K + R+ + R+ AELE A QRQ
Sbjct: 2053 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQ 2111
Query: 1924 I--QQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQ 1981
+ ++ + E+ E +A +Q+ +EVERL+ A+ E RERA ++
Sbjct: 2112 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK---AKVEEARRLRERAEQE 2168
Query: 1982 RVRGLEEQVSTLKGQLQQE 2000
R L+ + +LQ E
Sbjct: 2169 SARQLQLAQEAAQKRLQAE 2187
Score = 154 bits (389), Expect = 8e-37
Identities = 349/1516 (23%), Positives = 595/1516 (39%), Gaps = 229/1516 (15%)
Query: 550 GTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSA-----NELLSRE 604
G + + L ++S R L +Q L+D G E R V RL E R
Sbjct: 573 GEVERDLDKADSMIRLLFNDVQTLKD---GRHPQGEQMYRRVYRLHERLVAIRTEYNLRL 629
Query: 605 KSNLAH-SLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELER 663
K+ +A + QVAQ + +++ E + L+ +EE Q DGA +L
Sbjct: 630 KAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV--DGAEWGVDLPS 687
Query: 664 SHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ-AEKAEVAEALTKAEAGRVELEL 722
QL G L + + E R + RA L A + + L GR++L+
Sbjct: 688 VEAQL----GSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCL-----GRLDLQY 738
Query: 723 SMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV 782
+ L + +A L+ SL L + + ++ + LN + EEE+ R A
Sbjct: 739 AKL-LNSSKARLR-SLESLHSFVAAATKELMWLN----EKEEEEVGFDWSDRNTNMTA-- 790
Query: 783 AREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 842
++E L E E+ + ++ ++ PT+ ++ LQ Q + + +
Sbjct: 791 ---KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 847
Query: 843 LSGREQELEQAR---------REAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGR 893
E L++ REA+ Q++ L+ A R K + + ++ + + +
Sbjct: 848 CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQ-- 905
Query: 894 TLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQ 953
+E +L K L G L + + + QL+ R G+ LLA +
Sbjct: 906 ---DEKEQLNEYKGHLSG-LAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDY--------K 953
Query: 954 QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013
Q+ T K ++ Q + + + W+ L +
Sbjct: 954 QVEVTVHKG------------------------------DECQLVGPAQPSHWKVLSSSG 983
Query: 1014 AQ--------LQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS 1065
++ L +E +E + RLEA+ + L L + LLA ++ +
Sbjct: 984 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKS--LLAWQSLRRDVQ 1041
Query: 1066 LKESEKTALSEKLMGTRHSLATISLEME-----RQKRDAQSRQEQDRSTVNALTSELRDL 1120
L S A L A SLE+ R +DA +DR L
Sbjct: 1042 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR------------L 1089
Query: 1121 RAQREEAAAAHA-QEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE 1179
A+RE + +H Q++ + EQ + C+ E +++R QL E R R L
Sbjct: 1090 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE-TRTVHRLRLPL 1148
Query: 1180 AQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLA 1239
+ RE + R ++Q+A LG+G A L A + R L+L
Sbjct: 1149 DKEPARECAQ-RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT 1207
Query: 1240 NEDKEQKLAL----LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSE 1295
EQ +L LE+ +T G G +EV R+ E +E Q + + L++
Sbjct: 1208 LGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQLKEAQAVPATLPELEAT 1265
Query: 1296 NTRLGRELAELQGRLALGERAEKESR-RETLGLRQRLLKGEASLEVMRQELQVAQRKLQE 1354
L + A+ + + + E R + +G R + GE +EV R +VAQ +
Sbjct: 1266 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1325
Query: 1355 QEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQG 1414
Q +T + R E +QL +L R A LG L A R +
Sbjct: 1326 QAVLAQT----------DVRQRELEQLGR------QLRYYRESADPLGAWLQDARRRQEQ 1369
Query: 1415 LEA-ELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEG 1473
++A LA + R + L R G + A + + +A + +
Sbjct: 1370 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI------NAIKDYELQL 1423
Query: 1474 LNSPSTLE--CSPGSQPPSPGPATSPASPDLDPEAVRGALR-------EFLQELRSAQRE 1524
+ + LE SP +P + S +D L +F+ E E
Sbjct: 1424 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1483
Query: 1525 RDELRTQTSALNRQ-LAEMEAERDSATSRARQLQKAVAESE-EARRSVDGRLSGVQAELA 1582
+ L Q A R+ LAE+EA A + RQL +A A+++ +A R +Q E+
Sbjct: 1484 EERLAEQQRAEERERLAEVEA----ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539
Query: 1583 LQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKE 1642
+EE+ +++++R+ +++ L Q++E+E++A + + + ++E + R ++
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1596
Query: 1643 VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGT 1702
L+A+E QR EGELQ R + EAQ + Q+ + L+RQV D +
Sbjct: 1597 QLEATER-------QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK-- 1647
Query: 1703 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKA-----LT 1757
++E L +V+ EA + +L + + L ++A
Sbjct: 1648 ---------------RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1692
Query: 1758 ACEHDRQVLQERLDAARQALSEARKQSSSLGEQV----QTLRGEVADLELQRVEAEGQLQ 1813
E RQV A R A +E + + +S E+ ++L+ E + R EAE + Q
Sbjct: 1693 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1752
Query: 1814 QLREVLRQRQEGEAAALNTVQKLQDERRL-LQERLGSLQRALAQLEAEKREVERSALRLE 1872
Q E R R+E E K + RL LQ + Q++LAQ EAEK++ E
Sbjct: 1753 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA------ 1806
Query: 1873 KDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV- 1931
+R A RR K E + +R E AE EL E QRQ+ + AQ
Sbjct: 1807 -EREARRR--GKAEEQAVRQREL-----------------AEQEL-EKQRQLAEGTAQQR 1845
Query: 1932 VVLEQSHSPAQLEVDAQQQQLE-LQQEVERL-RSAQAQTERTLEARERAHRQRVRGLEEQ 1989
+ EQ + E + +QQ + L++E+ RL R A A T++ E A +VR E
Sbjct: 1846 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL--EAELAKVRAEMEV 1903
Query: 1990 VSTLKGQLQQELRRSS 2005
+ K + ++E R +S
Sbjct: 1904 LLASKARAEEESRSTS 1919
Score = 48.9 bits (115), Expect = 5e-05
Identities = 48/216 (22%), Positives = 98/216 (45%), Gaps = 17/216 (7%)
Query: 5 LARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPES 64
LA ++V L IQ +S + +L ++ + A + ++ + + +
Sbjct: 2559 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2618
Query: 65 PVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRL 124
LL T+ L E++ LLQ+ E + Q +A+ ++L A +++L + +
Sbjct: 2619 EQLLQETQALQQSFLSEKDSLLQR-----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2673
Query: 125 EPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYK 184
+ ++E QE + LV E RR+ E + RRK + Q+ +Q++ Q + L
Sbjct: 2674 QQQQME-QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL-------- 2724
Query: 185 KRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI 220
+E Q+L E+ LE+Q HS+++ ++ +
Sbjct: 2725 ---AEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2757
Score = 35.4 bits (80), Expect = 0.57
Identities = 89/418 (21%), Positives = 174/418 (41%), Gaps = 43/418 (10%)
Query: 1606 ERSLQATESELRASQEKISKMKANETKL-EGDKRRLKEVLDASESRTVKLELQ------R 1658
ER ++ E+ + K K E E DK R K + + E +L+
Sbjct: 441 ERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP 500
Query: 1659 RSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVE 1718
+E E + + + +RE Q ++ +R++ LQR V +++AG L E+LN
Sbjct: 501 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG---LCEEQLN------- 550
Query: 1719 ESEGALRDKVRGLTEA-LAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQAL 1777
+++ L+ VR L + Q + + DK + + L +D Q L+ D
Sbjct: 551 QADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF---NDVQTLK---DGRHPQG 604
Query: 1778 SEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQ 1837
+ ++ L E++ +R E +L L+ A Q + L+ Q +T++ LQ
Sbjct: 605 EQMYRRVYRLHERLVAIRTEY-NLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ 663
Query: 1838 DERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV 1897
D ++E + A ++ E + + R L +++++ + R+ D
Sbjct: 664 DLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR------GLHQSIEEFRAKIERARSDEG 717
Query: 1898 RLS-AEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL-Q 1955
+LS A +G L +L+ A + + +A++ LE HS A ++ + L +
Sbjct: 718 QLSPATRGAYRDCLGRLDLQYA---KLLNSSKARLRSLESLHS---FVAAATKELMWLNE 771
Query: 1956 QEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQ---QELRRSSAPFSP 2010
+E E + + + A++ ++ +R LE + +K +LQ L R P P
Sbjct: 772 KEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK-ELQNAGDRLLREDHPARP 828
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 266 bits (680), Expect = 2e-70
Identities = 459/1955 (23%), Positives = 813/1955 (41%), Gaps = 297/1955 (15%)
Query: 110 KYNAVSERLEQALR-LEPGELETQEPRGLVRQSVELRRQLQ--EEQASYRRKL------- 159
+Y + S +Q L+ LE G E + + + ++R QL+ E + +R +L
Sbjct: 935 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA 994
Query: 160 ----QAYQEGQQRQAQL------VQRLQG---KILQYKK---RCSELEQQLLERSGELEQ 203
Q E Q+ QA++ V RL K+L + L +L G+LEQ
Sbjct: 995 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1054
Query: 204 QR----------------LRDTEHSQD-LESALIRLEEEQQRSASLAQVNAM------LR 240
R +R T+ +++ L + +L+E Q A+L ++ A LR
Sbjct: 1055 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1114
Query: 241 EQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLW 300
Q + AL +++R R ++ R+ R E ++LL W
Sbjct: 1115 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERV--------AQLLERW 1166
Query: 301 RQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAES-RAEAALEK 359
+ V+ ++V+ +R+L QLG +L + G L R E +A +
Sbjct: 1167 QAVLA----QTDVR---QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1219
Query: 360 QALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQV 419
QA+ + +EQ + + ++ Q + + + EL L + + + +
Sbjct: 1220 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK 1279
Query: 420 NKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADA 479
+ E++ +QE L T E T +Q + SE+ ++ ER A+
Sbjct: 1280 KPKVQSGSESV----IQEYVDLRTHYSELTTLT----SQYIKFISETLRRMEEEERLAEQ 1331
Query: 480 SNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMR 539
QR R + +R + A + + A + ++++Q + +R
Sbjct: 1332 ----------QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381
Query: 540 GRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANE 599
R EA+ D ++ ++R+++E+LQ+LR ++ +QA + R A E
Sbjct: 1382 -REEAAVD-----------AQQQKRSIQEELQQLRQSSEAEIQA---------KARQA-E 1419
Query: 600 LLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
R + + ++V + Q E ++R + + LR + + E ++ A ++ R+RR
Sbjct: 1420 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1479
Query: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRA--TLQRDMLQAEKAEVAEALTKAEAGR 717
+++ ++ Q E + + K E RA L+ LQAE+AE + E R
Sbjct: 1480 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1539
Query: 718 VELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAE 777
T R+ EA LQ + + L + + + VAQL EE R+ Q +
Sbjct: 1540 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE----RRAQQQ 1595
Query: 778 QEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLA 837
EA AREE ER EL Q A + L L+ E AQ Q+ LA
Sbjct: 1596 AEAERAREEAER--ELERWQLKANEALRLRLQAEEVAQ-----------------QKSLA 1636
Query: 838 QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKE-------HAGLAVQLVAAER 890
Q E++ E+A REA+R+ +A E+A R++E +E G A Q +AAE+
Sbjct: 1637 QAEA-----EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1691
Query: 891 EGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAG 950
E L E + +++ LE L +QR+ A +R++LEAE + E L A
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1751
Query: 951 LRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELE 1010
++ +T EK+ E A + + EA R + A E QR E++AA + E
Sbjct: 1752 AEEESRSTSEKSKQRLEAEAGRFRELAEEAA---RLRALAEEAKRQRQLAEEDAARQRAE 1808
Query: 1011 AERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLL--LAESEKQQALSLKE 1068
AER E+L A EA + + EIA ++E + L LAE E Q L+E
Sbjct: 1809 AERVLA--------EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1860
Query: 1069 S---EKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQRE 1125
K + E+L R + + E+ERQK + Q R + E+ L+A E
Sbjct: 1861 QAAQHKADIEERLAQLRKASDS---ELERQKGLVEDTLRQRRQ----VEEEILALKASFE 1913
Query: 1126 EAAAAHAQ---EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
+AAA A+ E+ R++ A D + ++ EA R QL E+ R RRE E +
Sbjct: 1914 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-QLAAEEERR---RREAEERVQ 1969
Query: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERI-SLKLANE 1241
K ++E QR+ A E E E L+ EE R ++AE E L+LA E
Sbjct: 1970 KSLAAEEEAARQRKAALE----------EVERLKAKVEEARRLRERAEQESARQLQLAQE 2019
Query: 1242 DKEQKLALLEEART-AVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLG 1300
+++L E+A AV ++ EL+ LQ+ + + R E + RR + + +
Sbjct: 2020 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2079
Query: 1301 RELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQEL-QVAQRKLQEQEGEF 1359
RE A+ + ++ ER ++ + + Q + +A+ E +R+E Q A R+ Q ++
Sbjct: 2080 REAAQSRRQVEEAERLKQSAEEQA----QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2135
Query: 1360 RTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAEL 1419
R ++ +E+ + +Q L +E +L R L+L + + L+ EL
Sbjct: 2136 RQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR-------LQLEETDHQKNLLDEEL 2187
Query: 1420 ARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPST 1479
R++ + A Q RS + L R
Sbjct: 2188 QRLKAEATEAARQ----RSQVEEELFSVR------------------------------- 2212
Query: 1480 LECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRE--RDELRTQTSALNR 1537
++ S+ + A + A D + + L+E ++++ E R + Q +A R
Sbjct: 2213 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2272
Query: 1538 QLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRA 1597
QLAE + + A + +K A E R + L Q ELA +E RR + ++
Sbjct: 2273 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA--QEQARRLQEDKEQ 2330
Query: 1598 TLDQVATLERSLQAT-------ESELRASQEK----ISKMKANETKLEGDKRRLKEVLDA 1646
Q+A + Q T + E+ A E+ +++M + + E D +R ++ +
Sbjct: 2331 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2390
Query: 1647 SESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLT 1706
+ + EL + +Q + + A+ L++ + L+R+ + +A LQL
Sbjct: 2391 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL- 2449
Query: 1707 VERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNST---RDKNLHLQKALTACEHDR 1763
K EE + ++++ T+AL QS S + R++ + +KA
Sbjct: 2450 ---------KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL-----E 2495
Query: 1764 QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQ 1823
Q+ Q+ + A+Q E ++Q + ++ Q L VA +E EA + + E +R++Q
Sbjct: 2496 QLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASME----EARRRQHEAEEGVRRKQ 2548
Query: 1824 EGEAAALNTVQKLQDERR----LLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALR 1879
E +Q+L+ +RR LL E L+ L LE + R + + +VA
Sbjct: 2549 E-------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2601
Query: 1880 RTLDK---------VEREKLRSHEDTVR-LSAEKGRLDRTLTGAELE-LAEAQRQIQQLE 1928
+TL E E S + R +SA++ + L+ EL+ LA+ + +L
Sbjct: 2602 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2661
Query: 1929 AQVVV---LEQSHSPAQLEVDAQQQQLELQQEVER 1960
+ V L+ S A L + A ++L + ++R
Sbjct: 2662 RREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQR 2696
Score = 263 bits (673), Expect = 1e-69
Identities = 357/1544 (23%), Positives = 644/1544 (41%), Gaps = 172/1544 (11%)
Query: 543 EASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRS-ANELL 601
EA++ L LR Q + AL ++L+ ++ + Q H + EV+R R +LL
Sbjct: 1104 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1163
Query: 602 SREKSNLAHSLQVAQQQAEEL----RQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARV 657
R ++ LA + V Q++ E+L R RE L+ R R E+ Q + D V
Sbjct: 1164 ERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1222
Query: 658 RRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGR 717
R +L + LE++E EK E + K
Sbjct: 1223 REQLRQEQALLEEIER--------------------------HGEKVEECQRFAKQYINA 1256
Query: 718 V---ELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQL-----------E 763
+ EL+L K + E + K+ + +ES+ Q+ +DL ++L
Sbjct: 1257 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1316
Query: 764 EEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLP 823
E ++ +R AEQ+ EE+ERL E+ E RQ E + QA+ ++
Sbjct: 1317 ETLRRMEEEERLAEQQRA---EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1373
Query: 824 TLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEA----LERAAREKEALAKEHA 879
++ E + +E +Q ++EL+Q R+ ++ +++A E A R + + +E
Sbjct: 1374 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1433
Query: 880 GLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEAR---REQLEAEGQA 936
+ +QL A ER+ E LR E E + Q + +L + Q + + +
Sbjct: 1434 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1493
Query: 937 LLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAE---------------REAQ 981
L ++ E A +Q+ + E+ L E ++L QAE R A+
Sbjct: 1494 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553
Query: 982 ASLREQRAAHEEDLQRLQREKE------AAWRELEAERAQLQSQLQREQEELLARLEA-- 1033
A L+ +RA+ E +L+R + A RE RAQ Q++ +R +EE LE
Sbjct: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1613
Query: 1034 --EKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE 1091
E L + A + + + L AE+EKQ+ + +E+ + +E+ + LA LE
Sbjct: 1614 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1673
Query: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHA---QEVRRLQEQARDLGKQ 1148
+RQ + ++Q A EL LRA+ E+ +E+ RLQ +A ++
Sbjct: 1674 KQRQLAEGTAQQRL------AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1727
Query: 1149 RDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLR---ESQEGREVQRQEAGELRRSL 1205
R E ++R ++ +L ++ E K + E++ GR + E R+L
Sbjct: 1728 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1787
Query: 1206 GEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELR 1265
E AK + L + +A ++AE+ER+ +KLA + EA K E+
Sbjct: 1788 AEEAKRQRQLAEED----AARQRAEAERVLA--------EKLAAIGEATRL--KTEAEIA 1833
Query: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETL 1325
+E E RL RR ++ Q + L+ + + A+++ RLA +A
Sbjct: 1834 LKEKEAENERL--RRLAEDEAFQRRRLEEQ---AAQHKADIEERLAQLRKASDSELERQK 1888
Query: 1326 GLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA-RGTEKQQLDHA 1384
GL + L+ +E L+ + K + E R+ + E+ R E+ +L+ A
Sbjct: 1889 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1948
Query: 1385 RGLELKLEAARA--EAAE-LGLRLSAAEGRAQGLEAELARVE-VQRRAAEAQLGGLRSAL 1440
R +L E R EA E + L+A E A+ +A L VE ++ + EA+ R+
Sbjct: 1949 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2008
Query: 1441 RRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASP 1500
L A A + + A A E TL+ G A
Sbjct: 2009 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ-ELQQTLQQEQSVLDQLRGEA------ 2061
Query: 1501 DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNR--QLAEMEAERDSATSRARQLQK 1558
EA R A E + A+RE + R Q R Q AE +A+ + A + +
Sbjct: 2062 ----EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2117
Query: 1559 AVAESEEARRSVDGRLS-----GVQAELALQEESVRRSERERRATLDQVATLERSLQATE 1613
AE E ARR+ + + AE+ ++ ++ R++ ++ TL L+ T+
Sbjct: 2118 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2177
Query: 1614 SELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLS 1673
+ E++ ++KA T+ + +++E L + + +L + +E E L L
Sbjct: 2178 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE--NRALILR 2235
Query: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGA----LAKVEE-SEGALRDKV 1728
D++ + LQ+ + + +QVA+ + RL LA+ +E L++K+
Sbjct: 2236 DKDNTQRFLQEEAEKM-KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294
Query: 1729 RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQ---ERLDAARQALSEARKQSS 1785
+ + EA + + + K L ++A E Q+ Q E ++ L R++
Sbjct: 2295 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2354
Query: 1786 SLGEQVQTLRGEVADLELQRVEAEGQLQQLR-------EVLRQRQEGEAAALNTVQKLQD 1838
+ + + L+ VA++ + AE Q+ R E L + + + VQ L+
Sbjct: 2355 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2414
Query: 1839 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR 1898
+R+ L+ A+A+LE EK ++++ A L+ + V++E+L
Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQ------ 2464
Query: 1899 LSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV 1958
E L ++ + L + +R I+Q +A++ L Q ++ +QQ+ + Q E
Sbjct: 2465 ---ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521
Query: 1959 ERLRSAQAQTERTLEARERAH--RQRVRGLEEQVSTLKGQLQQE 2000
ER R + EAR R H + VR +E++ L+ Q +Q+
Sbjct: 2522 ERQRLVASME----EARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2561
Score = 234 bits (597), Expect = 6e-61
Identities = 425/1785 (23%), Positives = 742/1785 (41%), Gaps = 230/1785 (12%)
Query: 116 ERLEQALRLEPGELETQEP-----RGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQA 170
E + +L+ + E Q+P R +R + E+ +LQ+ +++ ++E R A
Sbjct: 1104 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE---RVA 1160
Query: 171 QLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI---RLEEEQQ 227
QL++R Q + Q R ELEQ ++LR S D A + R +EQ
Sbjct: 1161 QLLERWQAVLAQTDVRQRELEQL---------GRQLRYYRESADPLGAWLQDARRRQEQI 1211
Query: 228 RSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCR----------KELEHREAA 277
++ LA A+ REQL Q QAL E+I + C+ K+ E +
Sbjct: 1212 QAMPLADSQAV-REQLRQ----EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1266
Query: 278 WRRE-----------------EESFNAYFS--NEHSRLLLLWRQVVGFRRLVSEV--KMF 316
++ + E Y +S L L Q + F +SE +M
Sbjct: 1267 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF---ISETLRRME 1323
Query: 317 TERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVL 376
E L + R A EA L L A ++A+A E++A +L+++++++V+
Sbjct: 1324 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA---KELQQRMQEEVV 1380
Query: 377 REKDLA---QQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL 433
R ++ A QQQ +S ++ + +E + K + + E+ ++ + E + +
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE-----EEIRVV 1435
Query: 434 RLQEQAALETEDG-EGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRT 492
RLQ +A G EG Q LR A+ E+ Q ++ A+ ++ S ++
Sbjct: 1436 RLQLEATERQRGGAEGELQALRARAE------EAEAQKRQAQEEAERLRRQVQDESQRKR 1489
Query: 493 PSPPRRSSPGRGRSPR-RGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGT 551
+ +S + + R A L L +R Q + R R + L
Sbjct: 1490 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQVALETA 1548
Query: 552 LRKQLSDSESERRALEE---QLQR-LRDKTDGAMQAHEDAQREVQR---LRSANELLSRE 604
R ++ +S+R + E QL+R L+++ Q E+A+R Q+ A E RE
Sbjct: 1549 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1608
Query: 605 ------KSNLAHSLQVAQQQAEELRQEREKLQAA----QEELRRQRDRLEEEQEDAVQDG 654
K+N A L++ QAEE+ Q++ QA +EE R+ R + +E AV+
Sbjct: 1609 LERWQLKANEALRLRL---QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1665
Query: 655 ARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE 714
+ELE+ + E +R +EL+ +R + QR +L+ E A + A
Sbjct: 1666 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1725
Query: 715 AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQ------LEEEKSA 768
R ELE + K+RAE L SK A ES + + RL A+ L EE +
Sbjct: 1726 QKRQELEAELAKVRAEMEVLL--ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1783
Query: 769 LQG------RQRQ-AEQEATVAREEQERL--EELRLEQEVARQGLEG--SLRVAEQAQEA 817
L+ RQRQ AE++A R E ER+ E+L E R E +L+ E E
Sbjct: 1784 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1843
Query: 818 LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR-REAQRQVEALERAAREKEALAK 876
L + +R +L+EQ AQ + R +L +A E +RQ +E R++ + +
Sbjct: 1844 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1903
Query: 877 EHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARRE-QLEAEGQ 935
E L A L E R+R E S ++ A+LEA R+ QL AE
Sbjct: 1904 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRS-----KEQAELEAARQRQLAAE-- 1956
Query: 936 ALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL 995
+E E Q+ +A +E+A+ ++ +++ + + + + + R + A +E
Sbjct: 1957 -----EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2011
Query: 996 QRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLL 1055
++LQ +EAA + L+AE +Q++++EL ++ L +E + L Q R E
Sbjct: 2012 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL-------QQTLQQEQSVLDQLRGE---- 2060
Query: 1056 AESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTS 1115
AE+ ++ A +E+ A E R E ER K+ A+ Q Q R+ A
Sbjct: 2061 AEAARRAAEEAEEARVQAEREAAQSRRQVE-----EAERLKQSAEE-QAQARAQAQAAAE 2114
Query: 1116 ELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRR 1175
+LR A++E A A A++ Q+QA D ++ + AE+ Q +E LR
Sbjct: 2115 KLRK-EAEQEAARRAQAEQAALRQKQAADAEMEKHK--KFAEQTLRQKAQVEQELTTLRL 2171
Query: 1176 ELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERIS 1235
+L E + E + + EA E R + +E ++R EEL + E+E +
Sbjct: 2172 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2231
Query: 1236 LKLANEDKEQKLALLEEARTA--VGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLD 1293
L L ++D Q+ L EEA V +EA L QE R R A +L + R + +
Sbjct: 2232 LILRDKDNTQRF-LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2290
Query: 1294 SENTRLGRELAELQGRLAL----GERAEKESRR--------------ETLGL-------R 1328
E + +E L+ L E A++++RR ET G R
Sbjct: 2291 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2350
Query: 1329 QRLLKGEASLEVMR---QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHAR 1385
QR L+ A E ++ E+ AQ + +E FR + + L ++++ +
Sbjct: 2351 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2410
Query: 1386 GLELKLEAARAEAAELGLRLSAAEGRAQGLEAE-----LARVEVQRRAAEAQLGGLRSAL 1440
LE++ + + +A L ++ E + L+ E L E+Q E L ++
Sbjct: 2411 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2470
Query: 1441 RRGLGLGRAPSPAPRPVPGSPAR------DAPAEGSGEGLNSPSTLECSPGSQPPSPGPA 1494
+ L + R + A+ D A+ + L + Q A
Sbjct: 2471 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK--AQQLREEQQRQQQQMEQERQRLVA 2528
Query: 1495 TSPASPDLDPEAVRGALR--EFLQELRSAQRERDE-LRTQTSALNRQLAEMEAERDSATS 1551
+ + EA G R E LQ+L +R+++E L + L QL +E + +A +
Sbjct: 2529 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2588
Query: 1552 RARQLQKAVAESEEARRSVDGRLSGVQAELALQE--ESVRR---SERERRATLDQVATLE 1606
+ ++ + + + + L G AE + + +RR ++R + A + L+
Sbjct: 2589 HSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2648
Query: 1607 RSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDA-SESRTVKLELQRRSLEGEL 1665
R Q + +++++ + L+G +L A +E +V LQR+ L
Sbjct: 2649 RLAQG-----HTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS--- 2700
Query: 1666 QRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR 1725
+ L L + +A + L D V + +R + VK G + L+ L E + +
Sbjct: 2701 PGTALILLEAQAASGFLLDPVRN-RRLTVNEAVKEGVVG---PELHHKLLSAERAVTGYK 2756
Query: 1726 DKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERL 1770
D G +L Q+ +QK L EH ++L+ ++
Sbjct: 2757 DPYTGQQISLFQA-------------MQKGLIVREHGIRLLEAQI 2788
Score = 220 bits (560), Expect = 1e-56
Identities = 342/1419 (24%), Positives = 607/1419 (42%), Gaps = 206/1419 (14%)
Query: 75 SLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEP 134
+L ++EE +L +Q+ + + LA+ A ++ A ++ QA R E EL+ +
Sbjct: 1318 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER-EAKELQQRMQ 1376
Query: 135 RGLVRQ------SVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQR------------- 175
+VR+ + + +R +QEE R+ +A + + RQA+ +R
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436
Query: 176 ------------LQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLE 223
+G++ + R E E Q + E E+ R + + SQ A + L
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1496
Query: 224 EEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTR-CRKELEHREAAWRREE 282
+ A A+ + L++ + +R+ + R + LE + + E
Sbjct: 1497 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1556
Query: 283 ESFNAYFSNEHSRL-LLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR--TSRAVQEAG 339
+S A F+ + ++L L + V +L E + ++ Q E AR R ++
Sbjct: 1557 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ---QAEAERAREEAERELERWQ 1613
Query: 340 LGLSTGLRLAESRAEAALEKQALLQAQLEEQ-------------LRDKVLREKDLAQQQM 386
L + LRL +AE ++++L QA+ E+Q ++ +R+++LA+Q++
Sbjct: 1614 LKANEALRL-RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1672
Query: 387 QSDLDKADLSARVTELGLAVK----RLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALE 442
+ A+ +A+ LA + RL + + +Q + L E+L RLQ +AA
Sbjct: 1673 EKQRQLAEGTAQQR---LAAEQELIRLRAETEQGEQQRQLLEEELA-----RLQREAAAA 1724
Query: 443 TEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPG 502
T+ + L+ L + +E V L+ R + S S S QR + G
Sbjct: 1725 TQKRQELEAELAKVR------AEMEVLLASKARAEEESR-STSEKSKQRL-----EAEAG 1772
Query: 503 RGRSPRRGPSPACSDSSTL-ALIHSALHKRQLQVQDM-RGRYEASQDLLG---------- 550
R R +++ L AL A +RQL +D R R EA + L
Sbjct: 1773 RFRE-------LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1825
Query: 551 -------TLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANEL-LS 602
L+++ +++E RR E++ + R + A Q D + + +LR A++ L
Sbjct: 1826 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1885
Query: 603 REKSNLAHSLQVAQQQAEE---LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
R+K + +L+ +Q EE L+ EK A + EL + R+ ED ++ +
Sbjct: 1886 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1945
Query: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVE 719
E R RQL E +R A+E V+ A ++ E+ E +A K E R
Sbjct: 1946 EAARQ-RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA--KVEEAR-- 2000
Query: 720 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQE 779
R E + Q+S +L E+ AQ +L Q EE+ A +Q++ E +
Sbjct: 2001 --------RLRERAEQESARQLQLAQEA-AQKRL-------QAEEKAHAFAVQQKEQELQ 2044
Query: 780 ATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ-EALEQQLPTLRHER-SQLQEQLA 837
T+ ++EQ L++LR E E AR+ E + QA+ EA + + ER Q E+ A
Sbjct: 2045 QTL-QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2103
Query: 838 QLSRQLSGREQEL-EQARREAQRQVEALERAAREKEA---------------------LA 875
Q Q ++L ++A +EA R+ +A + A R+K+A +
Sbjct: 2104 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2163
Query: 876 KEHAGLAVQLVAAEREGRTLSEEATRLRLE-------KEALEGSLFEVQRQLAQLEARRE 928
+E L +QL + + L EE RL+ E + +E LF V+ Q+ +L +
Sbjct: 2164 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2223
Query: 929 QLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQR 988
++EAE +AL+L + T + + + + + AQ+ + + A+ L +QR
Sbjct: 2224 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR 2283
Query: 989 AAHEEDL-QRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQ 1047
A E+ L +++Q +EA + EAE Q Q +L +EQ RL+ +KE++++++A Q
Sbjct: 2284 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR---RLQEDKEQMAQQLAEETQ 2340
Query: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDR 1107
L E+E+Q+ L E +A +E+L + +A +S R + DAQ ++Q
Sbjct: 2341 GFQRTL---EAERQRQL-----EMSAEAERL---KLRVAEMSRAQARAEEDAQRFRKQAE 2389
Query: 1108 STVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLE 1167
L R A +E+ E++R Q +AE LR + LE
Sbjct: 2390 EIGEKLH---RTELATQEKVTLVQTLEIQRQQSD------------HDAERLREAIAELE 2434
Query: 1168 DARDGLRRELLEAQRKLRESQEGREVQ-RQEAGELRRS-LGEGAKEREALRRSNEELRSA 1225
++ L++E Q K E Q ++ Q QE L++S L E + R +E
Sbjct: 2435 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2494
Query: 1226 VKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQEL 1285
+ + E + E+++++ +E+ R + E R E E + ELQ+L
Sbjct: 2495 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2554
Query: 1286 ----RRQMKMLDSENTRLGR--ELAELQGRLALGE----RAEKESRRETLGLRQRLLKGE 1335
R+Q ++L EN RL +L E Q R AL A + + +TL + L G
Sbjct: 2555 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGP 2614
Query: 1336 ASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEAR 1374
A+ +RK+ Q R +E +L + E R
Sbjct: 2615 AAEAEPEHSFDGLRRKVSAQ----RLQEAGILSAEELQR 2649
Score = 195 bits (496), Expect = 3e-49
Identities = 323/1344 (24%), Positives = 558/1344 (41%), Gaps = 216/1344 (16%)
Query: 746 ESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV------AREEQERL-EELRLEQE 798
E AQ++ R +++L++ + L+ + + + ARE +R+ E+ + + E
Sbjct: 951 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE 1010
Query: 799 VARQGLEGSLRVAEQAQE--ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE 856
V G +G R++ +A++ AL + P RS+L+ L +L + S L E
Sbjct: 1011 VEGLG-KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS-----LSAIYLE 1064
Query: 857 AQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEV 916
+ + + R + E + + H EE + E +A+ +L E+
Sbjct: 1065 KLKTISLVIRGTQGAEEVLRAH------------------EEQLK---EAQAVPATLPEL 1103
Query: 917 QRQLAQLEARREQLEAEGQALLLAKETLTG-ELAGLRQQIIATQEKASLDKELMAQKLVQ 975
+ A L+ R Q EA+ ++ L G + G R Q Q D E+ +
Sbjct: 1104 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ----QRHGERDVEVERWR--- 1156
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQ------SQLQREQEEL-- 1027
ER AQ R Q + D++ QRE E R+L R +R QE++
Sbjct: 1157 -ERVAQLLERWQAVLAQTDVR--QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1213
Query: 1028 --LARLEAEKEELSEEIAALQQERDEGLLLAESE---KQQALSLKESEKTALSEKLMGTR 1082
LA +A +E+L +E A L++ G + E + KQ ++K+ E
Sbjct: 1214 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL----------- 1262
Query: 1083 HSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQA 1142
L T ++E A+ + Q S ++ E DLR E +Q ++ + E
Sbjct: 1263 -QLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1319
Query: 1143 RDLGKQRDSCLREAEELRTQLRLLEDARDGLR--------------RELLEAQRKLRESQ 1188
R + ++ ++ E R +L +E A + R RE E Q++++E
Sbjct: 1320 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1379
Query: 1189 EGREVQRQEAGELRRSLGEGAKEREALRRSNE-ELRSAVKKAES-ERISLKLANEDKEQK 1246
RE +A + +RS+ E E + LR+S+E E+++ ++AE+ ER L++ E + +
Sbjct: 1380 VRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436
Query: 1247 LAL--LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELA 1304
L L E R E LR +E E + +A+ E + LRRQ++ E+ R +
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQRKRQAEV 1493
Query: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER 1364
EL R+ +AE E+ RE +QR L+ +LE +R + + A+R+L++ E E R R
Sbjct: 1494 ELASRV----KAEAEAARE----KQRALQ---ALEELRLQAEEAERRLRQAEVE---RAR 1539
Query: 1365 RLLGSLEEARGTEKQQLDHARG--------LELKLEAARAEAAELGLRLSAAEGRAQGLE 1416
++ +LE A+ + + +L R LE L+ A+L R A Q E
Sbjct: 1540 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL--REEAERRAQQQAE 1597
Query: 1417 AELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNS 1476
AE AR E +R QL ALR L A A AE E
Sbjct: 1598 AERAREEAERELERWQLKA-NEALRLRL-------QAEEVAQQKSLAQAEAEKQKEEAER 1649
Query: 1477 PSTLECSPGSQPPSPGPATSPASPDLDPEA--VRGALREFL---QELRSAQRERDELRTQ 1531
+ G A +L+ + G ++ L QEL + E ++ Q
Sbjct: 1650 EARRR---GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1706
Query: 1532 TSALNRQLAEMEAERDSATSRARQLQKAVAE---------SEEARRSVDGRLSGVQAELA 1582
L +LA ++ E +AT + ++L+ +A+ + +AR + R + +++
Sbjct: 1707 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1766
Query: 1583 LQEESVR-RSERERRATLDQVAT-LERSLQATESELRASQEKISKMKANETKLEGDKRRL 1640
L+ E+ R R E A L +A +R Q E + + + ++ A + G+ RL
Sbjct: 1767 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1826
Query: 1641 KE----VLDASESRTVKLE-------LQRRSLEGELQRSRLGLSDREAQAQALQDR---- 1685
K L E+ +L QRR LE + + + + +R AQ + D
Sbjct: 1827 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1886
Query: 1686 ----VDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSAS 1741
V+ RQ E + L+ + E+ A++E G +R + Q A
Sbjct: 1887 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ--AE 1944
Query: 1742 LNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADL 1801
L + R + L ++ E R+ +ER+ + A EA +Q + E+V+ L+ +V +
Sbjct: 1945 LEAARQRQLAAEE-----ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1999
Query: 1802 ELQRVEAEG----QLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQL 1857
R AE QLQ +E ++R + E A +Q + + LQ+ L Q L QL
Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQKRLQAEEKA--HAFAVQQKEQELQQTLQQEQSVLDQL 2057
Query: 1858 EAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELEL 1917
E R+A E+ RV + ERE +S ++
Sbjct: 2058 RGEAEAARRAAEEAEEARV-------QAEREAAQSRR---------------------QV 2089
Query: 1918 AEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARER 1977
EA+R Q E EQ+ + AQ + A++ + E +QE R A+ R +A +
Sbjct: 2090 EEAERLKQSAE------EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD- 2142
Query: 1978 AHRQRVRGLEEQVSTLKGQLQQEL 2001
A ++ + EQ K Q++QEL
Sbjct: 2143 AEMEKHKKFAEQTLRQKAQVEQEL 2166
Score = 188 bits (477), Expect = 5e-47
Identities = 438/1879 (23%), Positives = 754/1879 (40%), Gaps = 272/1879 (14%)
Query: 271 LEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR 330
+ H AA+ EE F + F + +LW Q + F+ + K E D + G
Sbjct: 273 MRHHTAAF--EERRFPSSFEE----IEILWSQFLKFKEMELPAK---EADKNRSKGIYQS 323
Query: 331 TSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLR----EKDLAQQQM 386
AVQ L + G + E A+L+ E+QLR + R ++ + + QM
Sbjct: 324 LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILER--EKQLRSEFERLECLQRIVTKLQM 381
Query: 387 QSDLDKADLSARVTELGLAVKRLEKQNLEK--DQVNKDLTEKLEALESLRLQEQAALETE 444
++ L + L+ L V+ L + + +V +DL +K +++ L +
Sbjct: 382 EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL-DKADSMIRLLFNDV------ 434
Query: 445 DGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRG 504
QTL+D V A + +LR +G +P + +
Sbjct: 435 ------QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG--VAAPATQVAQVTL 486
Query: 505 RSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERR 564
+S +R P + STL + L V++ + R + ++ G + R
Sbjct: 487 QSVQRRPE---LEDSTLRYLQDLL----AWVEENQHRVDGAE--WGVDLPSVEAQLGSHR 537
Query: 565 ALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQ 624
L + ++ R K + A ++ Q + + L R A L ++ + L
Sbjct: 538 GLHQSIEEFRAKIERARS--DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 595
Query: 625 EREKLQAAQEELRRQRDRLEEE-----------QEDAVQDGARVRRELERSHRQLEQLEG 673
+ AA +EL ++ EEE + + + RELE +++++L+
Sbjct: 596 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 655
Query: 674 KRSVLAKELVEVREALS--RATLQRD---MLQAEKAEVAEALTKAEAGRVELELSMTKLR 728
L +E R + +A LQ MLQ EA K A + + +
Sbjct: 656 AGDRLLREDHPARPTVESFQAALQTQWSWMLQL--CCCIEAHLKENAAYFQFFSDVREAE 713
Query: 729 AEEASLQDSLSKLSALNESLAQDKL-----DLNRLVAQLEEEKSALQGRQRQAEQEATVA 783
+ LQ++L + + + S +L D QL E K L G ++A+ A V
Sbjct: 714 GQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK--AVVQ 771
Query: 784 REEQERLEELR----LEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQ-LAQ 838
+ + +R L + +E ++ ++ Q Q + S E +
Sbjct: 772 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 831
Query: 839 LSRQLSGREQELEQARREAQRQVEALERAARE-----KEALAKEHAGLAVQLVAAEREG- 892
+ + QE ++A + Q +AL + K LA + VQL+ +
Sbjct: 832 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT 891
Query: 893 -RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 951
RTL E R L L F Q A ++L AE + G +
Sbjct: 892 FRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREY---------GSCSHH 942
Query: 952 RQQIIATQEKASLDKELMAQKLVQAEREAQASLR--EQRAAHEEDLQRLQRE--KEAAWR 1007
QQ++ + E+ + +E Q+ + ++ + L E R H L L +E +E A R
Sbjct: 943 YQQLLQSLEQGA-QEESRCQRCISELKDIRLQLEACETRTVHRLRLP-LDKEPARECAQR 1000
Query: 1008 ELEAERAQLQ--------SQLQREQEELLARLEAE------KEELSEEIAALQQERDEGL 1053
E ++AQ + ++L E E++LA E + EL + L+Q R
Sbjct: 1001 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1060
Query: 1054 LLAESEKQQALSLK-----ESEKTALSEKLMGTRHSLATISLEMERQK---RDAQSRQEQ 1105
+ E K +L ++ E A E+L + AT+ E+E K + +++ E
Sbjct: 1061 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEA 1119
Query: 1106 DRSTVNALTSELRDLRAQREEAAAAHAQ---EVRRLQEQARDLGK-------QRDSCLRE 1155
+ T +AL ELR + E H + EV R +E+ L + Q D RE
Sbjct: 1120 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRE 1179
Query: 1156 AEELRTQLRLLEDARDGLRRELLEAQRK--------LRESQEGREVQRQEAGELRRSLGE 1207
E+L QLR ++ D L L +A+R+ L +SQ RE RQE L
Sbjct: 1180 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERH 1239
Query: 1208 GAKEREALRRSNEELRSAVKKAESERISLKLANED--KEQKLALLEEARTAVGKEAGELR 1265
G K E R + + + +A+K E + ++ K E K ++ +V +E +LR
Sbjct: 1240 GEKVEECQRFAKQYI-NAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1298
Query: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLG-RELAELQGRLALGERAEKESRRET 1324
T E+ + + + E R+M+ E RL ++ AE + RLA E A ++ R+
Sbjct: 1299 THYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLA 1354
Query: 1325 LGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHA 1384
Q + E + ++Q +Q + +E + + ++R S++E E QQL +
Sbjct: 1355 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR----SIQE----ELQQLRQS 1406
Query: 1385 RGLELKLEAARAEAAELG-LRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRG 1443
E++ +A +AEAAE LR+ E + + +L E QR AE +L LR+
Sbjct: 1407 SEAEIQAKARQAEAAERSRLRI---EEEIRVVRLQLEATERQRGGAEGELQALRARAEE- 1462
Query: 1444 LGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLD 1503
+ A+ A+ E L + SQ + +
Sbjct: 1463 ----------------AEAQKRQAQEEAERLRR----QVQDESQRKRQAEVELASRVKAE 1502
Query: 1504 PEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAES 1563
EA R E + A + +ELR Q R+L + E ER ARQ+Q A+
Sbjct: 1503 AEAAR--------EKQRALQALEELRLQAEEAERRLRQAEVER------ARQVQVAL--- 1545
Query: 1564 EEARRSVDGRLSG---------VQAELALQEESVR----RSERERRATLDQVATLERSLQ 1610
E A+RS + L Q E +LQEE V R E ERRA Q A ER+ +
Sbjct: 1546 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA--QQQAEAERARE 1603
Query: 1611 ATESELR-------------------ASQEKISKMKANETKLEGD---KRRLKEVLDASE 1648
E EL A Q+ +++ +A + K E + +RR K A
Sbjct: 1604 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1663
Query: 1649 SRTV---KLELQRRSLEG----------ELQRSRLGLSDREAQAQALQDRVDSLQRQVAD 1695
R + +LE QR+ EG EL R R E Q Q L++ + LQR+ A
Sbjct: 1664 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1723
Query: 1696 SEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE----ALAQSSASLNSTRDKNLH 1751
+ K L+ + ++ + + S+ ++ R +E L + ++
Sbjct: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1783
Query: 1752 LQKALTACEHDRQVLQERLDAARQALSEAR---KQSSSLGEQVQTLRGEVADLELQRVEA 1808
L+ + RQ+ +E DAARQ R ++ +++GE + L+ E A++ L+ EA
Sbjct: 1784 LRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATR-LKTE-AEIALKEKEA 1839
Query: 1809 EGQLQQLREVLRQRQEGEAAALNTVQKLQDERRL-LQERLGSLQRAL-AQLEAEKREVE- 1865
E E LR+ E EA +++ + + ++ERL L++A ++LE +K VE
Sbjct: 1840 E------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1893
Query: 1866 --RSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQ 1923
R ++E++ +AL+ + +K K + R+ + R+ AELE A QRQ
Sbjct: 1894 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQ 1952
Query: 1924 I--QQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQ 1981
+ ++ + E+ E +A +Q+ +EVERL+ A+ E RERA ++
Sbjct: 1953 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK---AKVEEARRLRERAEQE 2009
Query: 1982 RVRGLEEQVSTLKGQLQQE 2000
R L+ + +LQ E
Sbjct: 2010 SARQLQLAQEAAQKRLQAE 2028
Score = 154 bits (389), Expect = 8e-37
Identities = 349/1516 (23%), Positives = 595/1516 (39%), Gaps = 229/1516 (15%)
Query: 550 GTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSA-----NELLSRE 604
G + + L ++S R L +Q L+D G E R V RL E R
Sbjct: 414 GEVERDLDKADSMIRLLFNDVQTLKD---GRHPQGEQMYRRVYRLHERLVAIRTEYNLRL 470
Query: 605 KSNLAH-SLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELER 663
K+ +A + QVAQ + +++ E + L+ +EE Q DGA +L
Sbjct: 471 KAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV--DGAEWGVDLPS 528
Query: 664 SHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ-AEKAEVAEALTKAEAGRVELEL 722
QL G L + + E R + RA L A + + L GR++L+
Sbjct: 529 VEAQL----GSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCL-----GRLDLQY 579
Query: 723 SMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV 782
+ L + +A L+ SL L + + ++ + LN + EEE+ R A
Sbjct: 580 AKL-LNSSKARLR-SLESLHSFVAAATKELMWLN----EKEEEEVGFDWSDRNTNMTA-- 631
Query: 783 AREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 842
++E L E E+ + ++ ++ PT+ ++ LQ Q + + +
Sbjct: 632 ---KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 688
Query: 843 LSGREQELEQAR---------REAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGR 893
E L++ REA+ Q++ L+ A R K + + ++ + + +
Sbjct: 689 CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQ-- 746
Query: 894 TLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQ 953
+E +L K L G L + + + QL+ R G+ LLA +
Sbjct: 747 ---DEKEQLNEYKGHLSG-LAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDY--------K 794
Query: 954 QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013
Q+ T K ++ Q + + + W+ L +
Sbjct: 795 QVEVTVHKG------------------------------DECQLVGPAQPSHWKVLSSSG 824
Query: 1014 AQ--------LQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS 1065
++ L +E +E + RLEA+ + L L + LLA ++ +
Sbjct: 825 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKS--LLAWQSLRRDVQ 882
Query: 1066 LKESEKTALSEKLMGTRHSLATISLEME-----RQKRDAQSRQEQDRSTVNALTSELRDL 1120
L S A L A SLE+ R +DA +DR L
Sbjct: 883 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR------------L 930
Query: 1121 RAQREEAAAAHA-QEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE 1179
A+RE + +H Q++ + EQ + C+ E +++R QL E R R L
Sbjct: 931 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE-TRTVHRLRLPL 989
Query: 1180 AQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLA 1239
+ RE + R ++Q+A LG+G A L A + R L+L
Sbjct: 990 DKEPARECAQ-RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT 1048
Query: 1240 NEDKEQKLAL----LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSE 1295
EQ +L LE+ +T G G +EV R+ E +E Q + + L++
Sbjct: 1049 LGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQLKEAQAVPATLPELEAT 1106
Query: 1296 NTRLGRELAELQGRLALGERAEKESR-RETLGLRQRLLKGEASLEVMRQELQVAQRKLQE 1354
L + A+ + + + E R + +G R + GE +EV R +VAQ +
Sbjct: 1107 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1166
Query: 1355 QEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQG 1414
Q +T + R E +QL +L R A LG L A R +
Sbjct: 1167 QAVLAQT----------DVRQRELEQLGR------QLRYYRESADPLGAWLQDARRRQEQ 1210
Query: 1415 LEA-ELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEG 1473
++A LA + R + L R G + A + + +A + +
Sbjct: 1211 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI------NAIKDYELQL 1264
Query: 1474 LNSPSTLE--CSPGSQPPSPGPATSPASPDLDPEAVRGALR-------EFLQELRSAQRE 1524
+ + LE SP +P + S +D L +F+ E E
Sbjct: 1265 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1324
Query: 1525 RDELRTQTSALNRQ-LAEMEAERDSATSRARQLQKAVAESE-EARRSVDGRLSGVQAELA 1582
+ L Q A R+ LAE+EA A + RQL +A A+++ +A R +Q E+
Sbjct: 1325 EERLAEQQRAEERERLAEVEA----ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380
Query: 1583 LQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKE 1642
+EE+ +++++R+ +++ L Q++E+E++A + + + ++E + R ++
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1437
Query: 1643 VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGT 1702
L+A+E QR EGELQ R + EAQ + Q+ + L+RQV D +
Sbjct: 1438 QLEATER-------QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK-- 1488
Query: 1703 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKA-----LT 1757
++E L +V+ EA + +L + + L ++A
Sbjct: 1489 ---------------RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1533
Query: 1758 ACEHDRQVLQERLDAARQALSEARKQSSSLGEQV----QTLRGEVADLELQRVEAEGQLQ 1813
E RQV A R A +E + + +S E+ ++L+ E + R EAE + Q
Sbjct: 1534 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1593
Query: 1814 QLREVLRQRQEGEAAALNTVQKLQDERRL-LQERLGSLQRALAQLEAEKREVERSALRLE 1872
Q E R R+E E K + RL LQ + Q++LAQ EAEK++ E
Sbjct: 1594 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA------ 1647
Query: 1873 KDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV- 1931
+R A RR K E + +R E AE EL E QRQ+ + AQ
Sbjct: 1648 -EREARRR--GKAEEQAVRQREL-----------------AEQEL-EKQRQLAEGTAQQR 1686
Query: 1932 VVLEQSHSPAQLEVDAQQQQLE-LQQEVERL-RSAQAQTERTLEARERAHRQRVRGLEEQ 1989
+ EQ + E + +QQ + L++E+ RL R A A T++ E A +VR E
Sbjct: 1687 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL--EAELAKVRAEMEV 1744
Query: 1990 VSTLKGQLQQELRRSS 2005
+ K + ++E R +S
Sbjct: 1745 LLASKARAEEESRSTS 1760
Score = 48.9 bits (115), Expect = 5e-05
Identities = 48/216 (22%), Positives = 98/216 (45%), Gaps = 17/216 (7%)
Query: 5 LARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPES 64
LA ++V L IQ +S + +L ++ + A + ++ + + +
Sbjct: 2400 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2459
Query: 65 PVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRL 124
LL T+ L E++ LLQ+ E + Q +A+ ++L A +++L + +
Sbjct: 2460 EQLLQETQALQQSFLSEKDSLLQR-----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2514
Query: 125 EPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYK 184
+ ++E QE + LV E RR+ E + RRK + Q+ +Q++ Q + L
Sbjct: 2515 QQQQME-QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL-------- 2565
Query: 185 KRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI 220
+E Q+L E+ LE+Q HS+++ ++ +
Sbjct: 2566 ---AEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2598
Score = 35.4 bits (80), Expect = 0.57
Identities = 89/418 (21%), Positives = 174/418 (41%), Gaps = 43/418 (10%)
Query: 1606 ERSLQATESELRASQEKISKMKANETKL-EGDKRRLKEVLDASESRTVKLELQ------R 1658
ER ++ E+ + K K E E DK R K + + E +L+
Sbjct: 282 ERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP 341
Query: 1659 RSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVE 1718
+E E + + + +RE Q ++ +R++ LQR V +++AG L E+LN
Sbjct: 342 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG---LCEEQLN------- 391
Query: 1719 ESEGALRDKVRGLTEA-LAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQAL 1777
+++ L+ VR L + Q + + DK + + L +D Q L+ D
Sbjct: 392 QADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF---NDVQTLK---DGRHPQG 445
Query: 1778 SEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQ 1837
+ ++ L E++ +R E +L L+ A Q + L+ Q +T++ LQ
Sbjct: 446 EQMYRRVYRLHERLVAIRTEY-NLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ 504
Query: 1838 DERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV 1897
D ++E + A ++ E + + R L +++++ + R+ D
Sbjct: 505 DLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR------GLHQSIEEFRAKIERARSDEG 558
Query: 1898 RLS-AEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL-Q 1955
+LS A +G L +L+ A + + +A++ LE HS A ++ + L +
Sbjct: 559 QLSPATRGAYRDCLGRLDLQYA---KLLNSSKARLRSLESLHS---FVAAATKELMWLNE 612
Query: 1956 QEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQ---QELRRSSAPFSP 2010
+E E + + + A++ ++ +R LE + +K +LQ L R P P
Sbjct: 613 KEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK-ELQNAGDRLLREDHPARP 669
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 266 bits (680), Expect = 2e-70
Identities = 459/1955 (23%), Positives = 813/1955 (41%), Gaps = 297/1955 (15%)
Query: 110 KYNAVSERLEQALR-LEPGELETQEPRGLVRQSVELRRQLQ--EEQASYRRKL------- 159
+Y + S +Q L+ LE G E + + + ++R QL+ E + +R +L
Sbjct: 943 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA 1002
Query: 160 ----QAYQEGQQRQAQL------VQRLQG---KILQYKK---RCSELEQQLLERSGELEQ 203
Q E Q+ QA++ V RL K+L + L +L G+LEQ
Sbjct: 1003 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1062
Query: 204 QR----------------LRDTEHSQD-LESALIRLEEEQQRSASLAQVNAM------LR 240
R +R T+ +++ L + +L+E Q A+L ++ A LR
Sbjct: 1063 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1122
Query: 241 EQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLW 300
Q + AL +++R R ++ R+ R E ++LL W
Sbjct: 1123 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERV--------AQLLERW 1174
Query: 301 RQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAES-RAEAALEK 359
+ V+ ++V+ +R+L QLG +L + G L R E +A +
Sbjct: 1175 QAVLA----QTDVR---QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1227
Query: 360 QALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQV 419
QA+ + +EQ + + ++ Q + + + EL L + + + +
Sbjct: 1228 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK 1287
Query: 420 NKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADA 479
+ E++ +QE L T E T +Q + SE+ ++ ER A+
Sbjct: 1288 KPKVQSGSESV----IQEYVDLRTHYSELTTLT----SQYIKFISETLRRMEEEERLAEQ 1339
Query: 480 SNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMR 539
QR R + +R + A + + A + ++++Q + +R
Sbjct: 1340 ----------QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1389
Query: 540 GRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANE 599
R EA+ D ++ ++R+++E+LQ+LR ++ +QA + R A E
Sbjct: 1390 -REEAAVD-----------AQQQKRSIQEELQQLRQSSEAEIQA---------KARQA-E 1427
Query: 600 LLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
R + + ++V + Q E ++R + + LR + + E ++ A ++ R+RR
Sbjct: 1428 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1487
Query: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRA--TLQRDMLQAEKAEVAEALTKAEAGR 717
+++ ++ Q E + + K E RA L+ LQAE+AE + E R
Sbjct: 1488 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1547
Query: 718 VELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAE 777
T R+ EA LQ + + L + + + VAQL EE R+ Q +
Sbjct: 1548 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE----RRAQQQ 1603
Query: 778 QEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLA 837
EA AREE ER EL Q A + L L+ E AQ Q+ LA
Sbjct: 1604 AEAERAREEAER--ELERWQLKANEALRLRLQAEEVAQ-----------------QKSLA 1644
Query: 838 QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKE-------HAGLAVQLVAAER 890
Q E++ E+A REA+R+ +A E+A R++E +E G A Q +AAE+
Sbjct: 1645 QAEA-----EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1699
Query: 891 EGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAG 950
E L E + +++ LE L +QR+ A +R++LEAE + E L A
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1759
Query: 951 LRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELE 1010
++ +T EK+ E A + + EA R + A E QR E++AA + E
Sbjct: 1760 AEEESRSTSEKSKQRLEAEAGRFRELAEEAA---RLRALAEEAKRQRQLAEEDAARQRAE 1816
Query: 1011 AERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLL--LAESEKQQALSLKE 1068
AER E+L A EA + + EIA ++E + L LAE E Q L+E
Sbjct: 1817 AERVLA--------EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1868
Query: 1069 S---EKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQRE 1125
K + E+L R + + E+ERQK + Q R + E+ L+A E
Sbjct: 1869 QAAQHKADIEERLAQLRKASDS---ELERQKGLVEDTLRQRRQ----VEEEILALKASFE 1921
Query: 1126 EAAAAHAQ---EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
+AAA A+ E+ R++ A D + ++ EA R QL E+ R RRE E +
Sbjct: 1922 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-QLAAEEERR---RREAEERVQ 1977
Query: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERI-SLKLANE 1241
K ++E QR+ A E E E L+ EE R ++AE E L+LA E
Sbjct: 1978 KSLAAEEEAARQRKAALE----------EVERLKAKVEEARRLRERAEQESARQLQLAQE 2027
Query: 1242 DKEQKLALLEEART-AVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLG 1300
+++L E+A AV ++ EL+ LQ+ + + R E + RR + + +
Sbjct: 2028 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2087
Query: 1301 RELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQEL-QVAQRKLQEQEGEF 1359
RE A+ + ++ ER ++ + + Q + +A+ E +R+E Q A R+ Q ++
Sbjct: 2088 REAAQSRRQVEEAERLKQSAEEQA----QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2143
Query: 1360 RTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAEL 1419
R ++ +E+ + +Q L +E +L R L+L + + L+ EL
Sbjct: 2144 RQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR-------LQLEETDHQKNLLDEEL 2195
Query: 1420 ARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPST 1479
R++ + A Q RS + L R
Sbjct: 2196 QRLKAEATEAARQ----RSQVEEELFSVR------------------------------- 2220
Query: 1480 LECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRE--RDELRTQTSALNR 1537
++ S+ + A + A D + + L+E ++++ E R + Q +A R
Sbjct: 2221 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2280
Query: 1538 QLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRA 1597
QLAE + + A + +K A E R + L Q ELA +E RR + ++
Sbjct: 2281 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA--QEQARRLQEDKEQ 2338
Query: 1598 TLDQVATLERSLQAT-------ESELRASQEK----ISKMKANETKLEGDKRRLKEVLDA 1646
Q+A + Q T + E+ A E+ +++M + + E D +R ++ +
Sbjct: 2339 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2398
Query: 1647 SESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLT 1706
+ + EL + +Q + + A+ L++ + L+R+ + +A LQL
Sbjct: 2399 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL- 2457
Query: 1707 VERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNST---RDKNLHLQKALTACEHDR 1763
K EE + ++++ T+AL QS S + R++ + +KA
Sbjct: 2458 ---------KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL-----E 2503
Query: 1764 QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQ 1823
Q+ Q+ + A+Q E ++Q + ++ Q L VA +E EA + + E +R++Q
Sbjct: 2504 QLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASME----EARRRQHEAEEGVRRKQ 2556
Query: 1824 EGEAAALNTVQKLQDERR----LLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALR 1879
E +Q+L+ +RR LL E L+ L LE + R + + +VA
Sbjct: 2557 E-------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2609
Query: 1880 RTLDK---------VEREKLRSHEDTVR-LSAEKGRLDRTLTGAELE-LAEAQRQIQQLE 1928
+TL E E S + R +SA++ + L+ EL+ LA+ + +L
Sbjct: 2610 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2669
Query: 1929 AQVVV---LEQSHSPAQLEVDAQQQQLELQQEVER 1960
+ V L+ S A L + A ++L + ++R
Sbjct: 2670 RREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQR 2704
Score = 263 bits (673), Expect = 1e-69
Identities = 357/1544 (23%), Positives = 644/1544 (41%), Gaps = 172/1544 (11%)
Query: 543 EASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRS-ANELL 601
EA++ L LR Q + AL ++L+ ++ + Q H + EV+R R +LL
Sbjct: 1112 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1171
Query: 602 SREKSNLAHSLQVAQQQAEEL----RQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARV 657
R ++ LA + V Q++ E+L R RE L+ R R E+ Q + D V
Sbjct: 1172 ERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1230
Query: 658 RRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGR 717
R +L + LE++E EK E + K
Sbjct: 1231 REQLRQEQALLEEIER--------------------------HGEKVEECQRFAKQYINA 1264
Query: 718 V---ELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQL-----------E 763
+ EL+L K + E + K+ + +ES+ Q+ +DL ++L
Sbjct: 1265 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1324
Query: 764 EEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLP 823
E ++ +R AEQ+ EE+ERL E+ E RQ E + QA+ ++
Sbjct: 1325 ETLRRMEEEERLAEQQRA---EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1381
Query: 824 TLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEA----LERAAREKEALAKEHA 879
++ E + +E +Q ++EL+Q R+ ++ +++A E A R + + +E
Sbjct: 1382 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1441
Query: 880 GLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEAR---REQLEAEGQA 936
+ +QL A ER+ E LR E E + Q + +L + Q + + +
Sbjct: 1442 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1501
Query: 937 LLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAE---------------REAQ 981
L ++ E A +Q+ + E+ L E ++L QAE R A+
Sbjct: 1502 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561
Query: 982 ASLREQRAAHEEDLQRLQREKE------AAWRELEAERAQLQSQLQREQEELLARLEA-- 1033
A L+ +RA+ E +L+R + A RE RAQ Q++ +R +EE LE
Sbjct: 1562 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1621
Query: 1034 --EKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE 1091
E L + A + + + L AE+EKQ+ + +E+ + +E+ + LA LE
Sbjct: 1622 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1681
Query: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHA---QEVRRLQEQARDLGKQ 1148
+RQ + ++Q A EL LRA+ E+ +E+ RLQ +A ++
Sbjct: 1682 KQRQLAEGTAQQRL------AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1735
Query: 1149 RDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLR---ESQEGREVQRQEAGELRRSL 1205
R E ++R ++ +L ++ E K + E++ GR + E R+L
Sbjct: 1736 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1795
Query: 1206 GEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELR 1265
E AK + L + +A ++AE+ER+ +KLA + EA K E+
Sbjct: 1796 AEEAKRQRQLAEED----AARQRAEAERVLA--------EKLAAIGEATRL--KTEAEIA 1841
Query: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETL 1325
+E E RL RR ++ Q + L+ + + A+++ RLA +A
Sbjct: 1842 LKEKEAENERL--RRLAEDEAFQRRRLEEQ---AAQHKADIEERLAQLRKASDSELERQK 1896
Query: 1326 GLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA-RGTEKQQLDHA 1384
GL + L+ +E L+ + K + E R+ + E+ R E+ +L+ A
Sbjct: 1897 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1956
Query: 1385 RGLELKLEAARA--EAAE-LGLRLSAAEGRAQGLEAELARVE-VQRRAAEAQLGGLRSAL 1440
R +L E R EA E + L+A E A+ +A L VE ++ + EA+ R+
Sbjct: 1957 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2016
Query: 1441 RRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASP 1500
L A A + + A A E TL+ G A
Sbjct: 2017 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ-ELQQTLQQEQSVLDQLRGEA------ 2069
Query: 1501 DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNR--QLAEMEAERDSATSRARQLQK 1558
EA R A E + A+RE + R Q R Q AE +A+ + A + +
Sbjct: 2070 ----EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2125
Query: 1559 AVAESEEARRSVDGRLS-----GVQAELALQEESVRRSERERRATLDQVATLERSLQATE 1613
AE E ARR+ + + AE+ ++ ++ R++ ++ TL L+ T+
Sbjct: 2126 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2185
Query: 1614 SELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLS 1673
+ E++ ++KA T+ + +++E L + + +L + +E E L L
Sbjct: 2186 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE--NRALILR 2243
Query: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGA----LAKVEE-SEGALRDKV 1728
D++ + LQ+ + + +QVA+ + RL LA+ +E L++K+
Sbjct: 2244 DKDNTQRFLQEEAEKM-KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2302
Query: 1729 RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQ---ERLDAARQALSEARKQSS 1785
+ + EA + + + K L ++A E Q+ Q E ++ L R++
Sbjct: 2303 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2362
Query: 1786 SLGEQVQTLRGEVADLELQRVEAEGQLQQLR-------EVLRQRQEGEAAALNTVQKLQD 1838
+ + + L+ VA++ + AE Q+ R E L + + + VQ L+
Sbjct: 2363 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2422
Query: 1839 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR 1898
+R+ L+ A+A+LE EK ++++ A L+ + V++E+L
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQ------ 2472
Query: 1899 LSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV 1958
E L ++ + L + +R I+Q +A++ L Q ++ +QQ+ + Q E
Sbjct: 2473 ---ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529
Query: 1959 ERLRSAQAQTERTLEARERAH--RQRVRGLEEQVSTLKGQLQQE 2000
ER R + EAR R H + VR +E++ L+ Q +Q+
Sbjct: 2530 ERQRLVASME----EARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2569
Score = 234 bits (597), Expect = 6e-61
Identities = 425/1785 (23%), Positives = 742/1785 (41%), Gaps = 230/1785 (12%)
Query: 116 ERLEQALRLEPGELETQEP-----RGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQA 170
E + +L+ + E Q+P R +R + E+ +LQ+ +++ ++E R A
Sbjct: 1112 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE---RVA 1168
Query: 171 QLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI---RLEEEQQ 227
QL++R Q + Q R ELEQ ++LR S D A + R +EQ
Sbjct: 1169 QLLERWQAVLAQTDVRQRELEQL---------GRQLRYYRESADPLGAWLQDARRRQEQI 1219
Query: 228 RSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCR----------KELEHREAA 277
++ LA A+ REQL Q QAL E+I + C+ K+ E +
Sbjct: 1220 QAMPLADSQAV-REQLRQ----EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1274
Query: 278 WRRE-----------------EESFNAYFS--NEHSRLLLLWRQVVGFRRLVSEV--KMF 316
++ + E Y +S L L Q + F +SE +M
Sbjct: 1275 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF---ISETLRRME 1331
Query: 317 TERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVL 376
E L + R A EA L L A ++A+A E++A +L+++++++V+
Sbjct: 1332 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA---KELQQRMQEEVV 1388
Query: 377 REKDLA---QQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL 433
R ++ A QQQ +S ++ + +E + K + + E+ ++ + E + +
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE-----EEIRVV 1443
Query: 434 RLQEQAALETEDG-EGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRT 492
RLQ +A G EG Q LR A+ E+ Q ++ A+ ++ S ++
Sbjct: 1444 RLQLEATERQRGGAEGELQALRARAE------EAEAQKRQAQEEAERLRRQVQDESQRKR 1497
Query: 493 PSPPRRSSPGRGRSPR-RGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGT 551
+ +S + + R A L L +R Q + R R + L
Sbjct: 1498 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQVALETA 1556
Query: 552 LRKQLSDSESERRALEE---QLQR-LRDKTDGAMQAHEDAQREVQR---LRSANELLSRE 604
R ++ +S+R + E QL+R L+++ Q E+A+R Q+ A E RE
Sbjct: 1557 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1616
Query: 605 ------KSNLAHSLQVAQQQAEELRQEREKLQAA----QEELRRQRDRLEEEQEDAVQDG 654
K+N A L++ QAEE+ Q++ QA +EE R+ R + +E AV+
Sbjct: 1617 LERWQLKANEALRLRL---QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1673
Query: 655 ARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE 714
+ELE+ + E +R +EL+ +R + QR +L+ E A + A
Sbjct: 1674 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1733
Query: 715 AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQ------LEEEKSA 768
R ELE + K+RAE L SK A ES + + RL A+ L EE +
Sbjct: 1734 QKRQELEAELAKVRAEMEVLL--ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1791
Query: 769 LQG------RQRQ-AEQEATVAREEQERL--EELRLEQEVARQGLEG--SLRVAEQAQEA 817
L+ RQRQ AE++A R E ER+ E+L E R E +L+ E E
Sbjct: 1792 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1851
Query: 818 LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR-REAQRQVEALERAAREKEALAK 876
L + +R +L+EQ AQ + R +L +A E +RQ +E R++ + +
Sbjct: 1852 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1911
Query: 877 EHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARRE-QLEAEGQ 935
E L A L E R+R E S ++ A+LEA R+ QL AE
Sbjct: 1912 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRS-----KEQAELEAARQRQLAAE-- 1964
Query: 936 ALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL 995
+E E Q+ +A +E+A+ ++ +++ + + + + + R + A +E
Sbjct: 1965 -----EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2019
Query: 996 QRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLL 1055
++LQ +EAA + L+AE +Q++++EL ++ L +E + L Q R E
Sbjct: 2020 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL-------QQTLQQEQSVLDQLRGE---- 2068
Query: 1056 AESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTS 1115
AE+ ++ A +E+ A E R E ER K+ A+ Q Q R+ A
Sbjct: 2069 AEAARRAAEEAEEARVQAEREAAQSRRQVE-----EAERLKQSAEE-QAQARAQAQAAAE 2122
Query: 1116 ELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRR 1175
+LR A++E A A A++ Q+QA D ++ + AE+ Q +E LR
Sbjct: 2123 KLRK-EAEQEAARRAQAEQAALRQKQAADAEMEKHK--KFAEQTLRQKAQVEQELTTLRL 2179
Query: 1176 ELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERIS 1235
+L E + E + + EA E R + +E ++R EEL + E+E +
Sbjct: 2180 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2239
Query: 1236 LKLANEDKEQKLALLEEARTA--VGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLD 1293
L L ++D Q+ L EEA V +EA L QE R R A +L + R + +
Sbjct: 2240 LILRDKDNTQRF-LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2298
Query: 1294 SENTRLGRELAELQGRLAL----GERAEKESRR--------------ETLGL-------R 1328
E + +E L+ L E A++++RR ET G R
Sbjct: 2299 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2358
Query: 1329 QRLLKGEASLEVMR---QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHAR 1385
QR L+ A E ++ E+ AQ + +E FR + + L ++++ +
Sbjct: 2359 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2418
Query: 1386 GLELKLEAARAEAAELGLRLSAAEGRAQGLEAE-----LARVEVQRRAAEAQLGGLRSAL 1440
LE++ + + +A L ++ E + L+ E L E+Q E L ++
Sbjct: 2419 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2478
Query: 1441 RRGLGLGRAPSPAPRPVPGSPAR------DAPAEGSGEGLNSPSTLECSPGSQPPSPGPA 1494
+ L + R + A+ D A+ + L + Q A
Sbjct: 2479 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK--AQQLREEQQRQQQQMEQERQRLVA 2536
Query: 1495 TSPASPDLDPEAVRGALR--EFLQELRSAQRERDE-LRTQTSALNRQLAEMEAERDSATS 1551
+ + EA G R E LQ+L +R+++E L + L QL +E + +A +
Sbjct: 2537 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2596
Query: 1552 RARQLQKAVAESEEARRSVDGRLSGVQAELALQE--ESVRR---SERERRATLDQVATLE 1606
+ ++ + + + + L G AE + + +RR ++R + A + L+
Sbjct: 2597 HSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2656
Query: 1607 RSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDA-SESRTVKLELQRRSLEGEL 1665
R Q + +++++ + L+G +L A +E +V LQR+ L
Sbjct: 2657 RLAQG-----HTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS--- 2708
Query: 1666 QRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR 1725
+ L L + +A + L D V + +R + VK G + L+ L E + +
Sbjct: 2709 PGTALILLEAQAASGFLLDPVRN-RRLTVNEAVKEGVVG---PELHHKLLSAERAVTGYK 2764
Query: 1726 DKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERL 1770
D G +L Q+ +QK L EH ++L+ ++
Sbjct: 2765 DPYTGQQISLFQA-------------MQKGLIVREHGIRLLEAQI 2796
Score = 220 bits (560), Expect = 1e-56
Identities = 342/1419 (24%), Positives = 607/1419 (42%), Gaps = 206/1419 (14%)
Query: 75 SLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEP 134
+L ++EE +L +Q+ + + LA+ A ++ A ++ QA R E EL+ +
Sbjct: 1326 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER-EAKELQQRMQ 1384
Query: 135 RGLVRQ------SVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQR------------- 175
+VR+ + + +R +QEE R+ +A + + RQA+ +R
Sbjct: 1385 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1444
Query: 176 ------------LQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLE 223
+G++ + R E E Q + E E+ R + + SQ A + L
Sbjct: 1445 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1504
Query: 224 EEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTR-CRKELEHREAAWRREE 282
+ A A+ + L++ + +R+ + R + LE + + E
Sbjct: 1505 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1564
Query: 283 ESFNAYFSNEHSRL-LLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR--TSRAVQEAG 339
+S A F+ + ++L L + V +L E + ++ Q E AR R ++
Sbjct: 1565 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ---QAEAERAREEAERELERWQ 1621
Query: 340 LGLSTGLRLAESRAEAALEKQALLQAQLEEQ-------------LRDKVLREKDLAQQQM 386
L + LRL +AE ++++L QA+ E+Q ++ +R+++LA+Q++
Sbjct: 1622 LKANEALRL-RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1680
Query: 387 QSDLDKADLSARVTELGLAVK----RLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALE 442
+ A+ +A+ LA + RL + + +Q + L E+L RLQ +AA
Sbjct: 1681 EKQRQLAEGTAQQR---LAAEQELIRLRAETEQGEQQRQLLEEELA-----RLQREAAAA 1732
Query: 443 TEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPG 502
T+ + L+ L + +E V L+ R + S S S QR + G
Sbjct: 1733 TQKRQELEAELAKVR------AEMEVLLASKARAEEESR-STSEKSKQRL-----EAEAG 1780
Query: 503 RGRSPRRGPSPACSDSSTL-ALIHSALHKRQLQVQDM-RGRYEASQDLLG---------- 550
R R +++ L AL A +RQL +D R R EA + L
Sbjct: 1781 RFRE-------LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1833
Query: 551 -------TLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANEL-LS 602
L+++ +++E RR E++ + R + A Q D + + +LR A++ L
Sbjct: 1834 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1893
Query: 603 REKSNLAHSLQVAQQQAEE---LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
R+K + +L+ +Q EE L+ EK A + EL + R+ ED ++ +
Sbjct: 1894 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1953
Query: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVE 719
E R RQL E +R A+E V+ A ++ E+ E +A K E R
Sbjct: 1954 EAARQ-RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA--KVEEAR-- 2008
Query: 720 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQE 779
R E + Q+S +L E+ AQ +L Q EE+ A +Q++ E +
Sbjct: 2009 --------RLRERAEQESARQLQLAQEA-AQKRL-------QAEEKAHAFAVQQKEQELQ 2052
Query: 780 ATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ-EALEQQLPTLRHER-SQLQEQLA 837
T+ ++EQ L++LR E E AR+ E + QA+ EA + + ER Q E+ A
Sbjct: 2053 QTL-QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2111
Query: 838 QLSRQLSGREQEL-EQARREAQRQVEALERAAREKEA---------------------LA 875
Q Q ++L ++A +EA R+ +A + A R+K+A +
Sbjct: 2112 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2171
Query: 876 KEHAGLAVQLVAAEREGRTLSEEATRLRLE-------KEALEGSLFEVQRQLAQLEARRE 928
+E L +QL + + L EE RL+ E + +E LF V+ Q+ +L +
Sbjct: 2172 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2231
Query: 929 QLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQR 988
++EAE +AL+L + T + + + + + AQ+ + + A+ L +QR
Sbjct: 2232 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR 2291
Query: 989 AAHEEDL-QRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQ 1047
A E+ L +++Q +EA + EAE Q Q +L +EQ RL+ +KE++++++A Q
Sbjct: 2292 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR---RLQEDKEQMAQQLAEETQ 2348
Query: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDR 1107
L E+E+Q+ L E +A +E+L + +A +S R + DAQ ++Q
Sbjct: 2349 GFQRTL---EAERQRQL-----EMSAEAERL---KLRVAEMSRAQARAEEDAQRFRKQAE 2397
Query: 1108 STVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLE 1167
L R A +E+ E++R Q +AE LR + LE
Sbjct: 2398 EIGEKLH---RTELATQEKVTLVQTLEIQRQQSD------------HDAERLREAIAELE 2442
Query: 1168 DARDGLRRELLEAQRKLRESQEGREVQ-RQEAGELRRS-LGEGAKEREALRRSNEELRSA 1225
++ L++E Q K E Q ++ Q QE L++S L E + R +E
Sbjct: 2443 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2502
Query: 1226 VKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQEL 1285
+ + E + E+++++ +E+ R + E R E E + ELQ+L
Sbjct: 2503 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2562
Query: 1286 ----RRQMKMLDSENTRLGR--ELAELQGRLALGE----RAEKESRRETLGLRQRLLKGE 1335
R+Q ++L EN RL +L E Q R AL A + + +TL + L G
Sbjct: 2563 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGP 2622
Query: 1336 ASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEAR 1374
A+ +RK+ Q R +E +L + E R
Sbjct: 2623 AAEAEPEHSFDGLRRKVSAQ----RLQEAGILSAEELQR 2657
Score = 195 bits (496), Expect = 3e-49
Identities = 323/1344 (24%), Positives = 558/1344 (41%), Gaps = 216/1344 (16%)
Query: 746 ESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV------AREEQERL-EELRLEQE 798
E AQ++ R +++L++ + L+ + + + ARE +R+ E+ + + E
Sbjct: 959 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE 1018
Query: 799 VARQGLEGSLRVAEQAQE--ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE 856
V G +G R++ +A++ AL + P RS+L+ L +L + S L E
Sbjct: 1019 VEGLG-KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS-----LSAIYLE 1072
Query: 857 AQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEV 916
+ + + R + E + + H EE + E +A+ +L E+
Sbjct: 1073 KLKTISLVIRGTQGAEEVLRAH------------------EEQLK---EAQAVPATLPEL 1111
Query: 917 QRQLAQLEARREQLEAEGQALLLAKETLTG-ELAGLRQQIIATQEKASLDKELMAQKLVQ 975
+ A L+ R Q EA+ ++ L G + G R Q Q D E+ +
Sbjct: 1112 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ----QRHGERDVEVERWR--- 1164
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQ------SQLQREQEEL-- 1027
ER AQ R Q + D++ QRE E R+L R +R QE++
Sbjct: 1165 -ERVAQLLERWQAVLAQTDVR--QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1221
Query: 1028 --LARLEAEKEELSEEIAALQQERDEGLLLAESE---KQQALSLKESEKTALSEKLMGTR 1082
LA +A +E+L +E A L++ G + E + KQ ++K+ E
Sbjct: 1222 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL----------- 1270
Query: 1083 HSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQA 1142
L T ++E A+ + Q S ++ E DLR E +Q ++ + E
Sbjct: 1271 -QLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1327
Query: 1143 RDLGKQRDSCLREAEELRTQLRLLEDARDGLR--------------RELLEAQRKLRESQ 1188
R + ++ ++ E R +L +E A + R RE E Q++++E
Sbjct: 1328 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1387
Query: 1189 EGREVQRQEAGELRRSLGEGAKEREALRRSNE-ELRSAVKKAES-ERISLKLANEDKEQK 1246
RE +A + +RS+ E E + LR+S+E E+++ ++AE+ ER L++ E + +
Sbjct: 1388 VRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1444
Query: 1247 LAL--LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELA 1304
L L E R E LR +E E + +A+ E + LRRQ++ E+ R +
Sbjct: 1445 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQRKRQAEV 1501
Query: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER 1364
EL R+ +AE E+ RE +QR L+ +LE +R + + A+R+L++ E E R R
Sbjct: 1502 ELASRV----KAEAEAARE----KQRALQ---ALEELRLQAEEAERRLRQAEVE---RAR 1547
Query: 1365 RLLGSLEEARGTEKQQLDHARG--------LELKLEAARAEAAELGLRLSAAEGRAQGLE 1416
++ +LE A+ + + +L R LE L+ A+L R A Q E
Sbjct: 1548 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL--REEAERRAQQQAE 1605
Query: 1417 AELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNS 1476
AE AR E +R QL ALR L A A AE E
Sbjct: 1606 AERAREEAERELERWQLKA-NEALRLRL-------QAEEVAQQKSLAQAEAEKQKEEAER 1657
Query: 1477 PSTLECSPGSQPPSPGPATSPASPDLDPEA--VRGALREFL---QELRSAQRERDELRTQ 1531
+ G A +L+ + G ++ L QEL + E ++ Q
Sbjct: 1658 EARRR---GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1714
Query: 1532 TSALNRQLAEMEAERDSATSRARQLQKAVAE---------SEEARRSVDGRLSGVQAELA 1582
L +LA ++ E +AT + ++L+ +A+ + +AR + R + +++
Sbjct: 1715 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1774
Query: 1583 LQEESVR-RSERERRATLDQVAT-LERSLQATESELRASQEKISKMKANETKLEGDKRRL 1640
L+ E+ R R E A L +A +R Q E + + + ++ A + G+ RL
Sbjct: 1775 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1834
Query: 1641 KE----VLDASESRTVKLE-------LQRRSLEGELQRSRLGLSDREAQAQALQDR---- 1685
K L E+ +L QRR LE + + + + +R AQ + D
Sbjct: 1835 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1894
Query: 1686 ----VDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSAS 1741
V+ RQ E + L+ + E+ A++E G +R + Q A
Sbjct: 1895 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ--AE 1952
Query: 1742 LNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADL 1801
L + R + L ++ E R+ +ER+ + A EA +Q + E+V+ L+ +V +
Sbjct: 1953 LEAARQRQLAAEE-----ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2007
Query: 1802 ELQRVEAEG----QLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQL 1857
R AE QLQ +E ++R + E A +Q + + LQ+ L Q L QL
Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQKRLQAEEKA--HAFAVQQKEQELQQTLQQEQSVLDQL 2065
Query: 1858 EAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELEL 1917
E R+A E+ RV + ERE +S ++
Sbjct: 2066 RGEAEAARRAAEEAEEARV-------QAEREAAQSRR---------------------QV 2097
Query: 1918 AEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARER 1977
EA+R Q E EQ+ + AQ + A++ + E +QE R A+ R +A +
Sbjct: 2098 EEAERLKQSAE------EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD- 2150
Query: 1978 AHRQRVRGLEEQVSTLKGQLQQEL 2001
A ++ + EQ K Q++QEL
Sbjct: 2151 AEMEKHKKFAEQTLRQKAQVEQEL 2174
Score = 188 bits (477), Expect = 5e-47
Identities = 438/1879 (23%), Positives = 754/1879 (40%), Gaps = 272/1879 (14%)
Query: 271 LEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR 330
+ H AA+ EE F + F + +LW Q + F+ + K E D + G
Sbjct: 281 MRHHTAAF--EERRFPSSFEE----IEILWSQFLKFKEMELPAK---EADKNRSKGIYQS 331
Query: 331 TSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLR----EKDLAQQQM 386
AVQ L + G + E A+L+ E+QLR + R ++ + + QM
Sbjct: 332 LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILER--EKQLRSEFERLECLQRIVTKLQM 389
Query: 387 QSDLDKADLSARVTELGLAVKRLEKQNLEK--DQVNKDLTEKLEALESLRLQEQAALETE 444
++ L + L+ L V+ L + + +V +DL +K +++ L +
Sbjct: 390 EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL-DKADSMIRLLFNDV------ 442
Query: 445 DGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRG 504
QTL+D V A + +LR +G +P + +
Sbjct: 443 ------QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG--VAAPATQVAQVTL 494
Query: 505 RSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERR 564
+S +R P + STL + L V++ + R + ++ G + R
Sbjct: 495 QSVQRRPE---LEDSTLRYLQDLL----AWVEENQHRVDGAE--WGVDLPSVEAQLGSHR 545
Query: 565 ALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQ 624
L + ++ R K + A ++ Q + + L R A L ++ + L
Sbjct: 546 GLHQSIEEFRAKIERARS--DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 603
Query: 625 EREKLQAAQEELRRQRDRLEEE-----------QEDAVQDGARVRRELERSHRQLEQLEG 673
+ AA +EL ++ EEE + + + RELE +++++L+
Sbjct: 604 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 663
Query: 674 KRSVLAKELVEVREALS--RATLQRD---MLQAEKAEVAEALTKAEAGRVELELSMTKLR 728
L +E R + +A LQ MLQ EA K A + + +
Sbjct: 664 AGDRLLREDHPARPTVESFQAALQTQWSWMLQL--CCCIEAHLKENAAYFQFFSDVREAE 721
Query: 729 AEEASLQDSLSKLSALNESLAQDKL-----DLNRLVAQLEEEKSALQGRQRQAEQEATVA 783
+ LQ++L + + + S +L D QL E K L G ++A+ A V
Sbjct: 722 GQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK--AVVQ 779
Query: 784 REEQERLEELR----LEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQ-LAQ 838
+ + +R L + +E ++ ++ Q Q + S E +
Sbjct: 780 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 839
Query: 839 LSRQLSGREQELEQARREAQRQVEALERAARE-----KEALAKEHAGLAVQLVAAEREG- 892
+ + QE ++A + Q +AL + K LA + VQL+ +
Sbjct: 840 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT 899
Query: 893 -RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 951
RTL E R L L F Q A ++L AE + G +
Sbjct: 900 FRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREY---------GSCSHH 950
Query: 952 RQQIIATQEKASLDKELMAQKLVQAEREAQASLR--EQRAAHEEDLQRLQRE--KEAAWR 1007
QQ++ + E+ + +E Q+ + ++ + L E R H L L +E +E A R
Sbjct: 951 YQQLLQSLEQGA-QEESRCQRCISELKDIRLQLEACETRTVHRLRLP-LDKEPARECAQR 1008
Query: 1008 ELEAERAQLQ--------SQLQREQEELLARLEAE------KEELSEEIAALQQERDEGL 1053
E ++AQ + ++L E E++LA E + EL + L+Q R
Sbjct: 1009 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1068
Query: 1054 LLAESEKQQALSLK-----ESEKTALSEKLMGTRHSLATISLEMERQK---RDAQSRQEQ 1105
+ E K +L ++ E A E+L + AT+ E+E K + +++ E
Sbjct: 1069 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEA 1127
Query: 1106 DRSTVNALTSELRDLRAQREEAAAAHAQ---EVRRLQEQARDLGK-------QRDSCLRE 1155
+ T +AL ELR + E H + EV R +E+ L + Q D RE
Sbjct: 1128 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRE 1187
Query: 1156 AEELRTQLRLLEDARDGLRRELLEAQRK--------LRESQEGREVQRQEAGELRRSLGE 1207
E+L QLR ++ D L L +A+R+ L +SQ RE RQE L
Sbjct: 1188 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERH 1247
Query: 1208 GAKEREALRRSNEELRSAVKKAESERISLKLANED--KEQKLALLEEARTAVGKEAGELR 1265
G K E R + + + +A+K E + ++ K E K ++ +V +E +LR
Sbjct: 1248 GEKVEECQRFAKQYI-NAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1306
Query: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLG-RELAELQGRLALGERAEKESRRET 1324
T E+ + + + E R+M+ E RL ++ AE + RLA E A ++ R+
Sbjct: 1307 THYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLA 1362
Query: 1325 LGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHA 1384
Q + E + ++Q +Q + +E + + ++R S++E E QQL +
Sbjct: 1363 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR----SIQE----ELQQLRQS 1414
Query: 1385 RGLELKLEAARAEAAELG-LRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRG 1443
E++ +A +AEAAE LR+ E + + +L E QR AE +L LR+
Sbjct: 1415 SEAEIQAKARQAEAAERSRLRI---EEEIRVVRLQLEATERQRGGAEGELQALRARAEE- 1470
Query: 1444 LGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLD 1503
+ A+ A+ E L + SQ + +
Sbjct: 1471 ----------------AEAQKRQAQEEAERLRR----QVQDESQRKRQAEVELASRVKAE 1510
Query: 1504 PEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAES 1563
EA R E + A + +ELR Q R+L + E ER ARQ+Q A+
Sbjct: 1511 AEAAR--------EKQRALQALEELRLQAEEAERRLRQAEVER------ARQVQVAL--- 1553
Query: 1564 EEARRSVDGRLSG---------VQAELALQEESVR----RSERERRATLDQVATLERSLQ 1610
E A+RS + L Q E +LQEE V R E ERRA Q A ER+ +
Sbjct: 1554 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA--QQQAEAERARE 1611
Query: 1611 ATESELR-------------------ASQEKISKMKANETKLEGD---KRRLKEVLDASE 1648
E EL A Q+ +++ +A + K E + +RR K A
Sbjct: 1612 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1671
Query: 1649 SRTV---KLELQRRSLEG----------ELQRSRLGLSDREAQAQALQDRVDSLQRQVAD 1695
R + +LE QR+ EG EL R R E Q Q L++ + LQR+ A
Sbjct: 1672 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1731
Query: 1696 SEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE----ALAQSSASLNSTRDKNLH 1751
+ K L+ + ++ + + S+ ++ R +E L + ++
Sbjct: 1732 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1791
Query: 1752 LQKALTACEHDRQVLQERLDAARQALSEAR---KQSSSLGEQVQTLRGEVADLELQRVEA 1808
L+ + RQ+ +E DAARQ R ++ +++GE + L+ E A++ L+ EA
Sbjct: 1792 LRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATR-LKTE-AEIALKEKEA 1847
Query: 1809 EGQLQQLREVLRQRQEGEAAALNTVQKLQDERRL-LQERLGSLQRAL-AQLEAEKREVE- 1865
E E LR+ E EA +++ + + ++ERL L++A ++LE +K VE
Sbjct: 1848 E------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1901
Query: 1866 --RSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQ 1923
R ++E++ +AL+ + +K K + R+ + R+ AELE A QRQ
Sbjct: 1902 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQ 1960
Query: 1924 I--QQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQ 1981
+ ++ + E+ E +A +Q+ +EVERL+ A+ E RERA ++
Sbjct: 1961 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK---AKVEEARRLRERAEQE 2017
Query: 1982 RVRGLEEQVSTLKGQLQQE 2000
R L+ + +LQ E
Sbjct: 2018 SARQLQLAQEAAQKRLQAE 2036
Score = 154 bits (389), Expect = 8e-37
Identities = 349/1516 (23%), Positives = 595/1516 (39%), Gaps = 229/1516 (15%)
Query: 550 GTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSA-----NELLSRE 604
G + + L ++S R L +Q L+D G E R V RL E R
Sbjct: 422 GEVERDLDKADSMIRLLFNDVQTLKD---GRHPQGEQMYRRVYRLHERLVAIRTEYNLRL 478
Query: 605 KSNLAH-SLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELER 663
K+ +A + QVAQ + +++ E + L+ +EE Q DGA +L
Sbjct: 479 KAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV--DGAEWGVDLPS 536
Query: 664 SHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ-AEKAEVAEALTKAEAGRVELEL 722
QL G L + + E R + RA L A + + L GR++L+
Sbjct: 537 VEAQL----GSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCL-----GRLDLQY 587
Query: 723 SMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV 782
+ L + +A L+ SL L + + ++ + LN + EEE+ R A
Sbjct: 588 AKL-LNSSKARLR-SLESLHSFVAAATKELMWLN----EKEEEEVGFDWSDRNTNMTA-- 639
Query: 783 AREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 842
++E L E E+ + ++ ++ PT+ ++ LQ Q + + +
Sbjct: 640 ---KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 696
Query: 843 LSGREQELEQAR---------REAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGR 893
E L++ REA+ Q++ L+ A R K + + ++ + + +
Sbjct: 697 CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQ-- 754
Query: 894 TLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQ 953
+E +L K L G L + + + QL+ R G+ LLA +
Sbjct: 755 ---DEKEQLNEYKGHLSG-LAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDY--------K 802
Query: 954 QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013
Q+ T K ++ Q + + + W+ L +
Sbjct: 803 QVEVTVHKG------------------------------DECQLVGPAQPSHWKVLSSSG 832
Query: 1014 AQ--------LQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS 1065
++ L +E +E + RLEA+ + L L + LLA ++ +
Sbjct: 833 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKS--LLAWQSLRRDVQ 890
Query: 1066 LKESEKTALSEKLMGTRHSLATISLEME-----RQKRDAQSRQEQDRSTVNALTSELRDL 1120
L S A L A SLE+ R +DA +DR L
Sbjct: 891 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR------------L 938
Query: 1121 RAQREEAAAAHA-QEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE 1179
A+RE + +H Q++ + EQ + C+ E +++R QL E R R L
Sbjct: 939 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE-TRTVHRLRLPL 997
Query: 1180 AQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLA 1239
+ RE + R ++Q+A LG+G A L A + R L+L
Sbjct: 998 DKEPARECAQ-RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT 1056
Query: 1240 NEDKEQKLAL----LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSE 1295
EQ +L LE+ +T G G +EV R+ E +E Q + + L++
Sbjct: 1057 LGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQLKEAQAVPATLPELEAT 1114
Query: 1296 NTRLGRELAELQGRLALGERAEKESR-RETLGLRQRLLKGEASLEVMRQELQVAQRKLQE 1354
L + A+ + + + E R + +G R + GE +EV R +VAQ +
Sbjct: 1115 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1174
Query: 1355 QEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQG 1414
Q +T + R E +QL +L R A LG L A R +
Sbjct: 1175 QAVLAQT----------DVRQRELEQLGR------QLRYYRESADPLGAWLQDARRRQEQ 1218
Query: 1415 LEA-ELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEG 1473
++A LA + R + L R G + A + + +A + +
Sbjct: 1219 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI------NAIKDYELQL 1272
Query: 1474 LNSPSTLE--CSPGSQPPSPGPATSPASPDLDPEAVRGALR-------EFLQELRSAQRE 1524
+ + LE SP +P + S +D L +F+ E E
Sbjct: 1273 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1332
Query: 1525 RDELRTQTSALNRQ-LAEMEAERDSATSRARQLQKAVAESE-EARRSVDGRLSGVQAELA 1582
+ L Q A R+ LAE+EA A + RQL +A A+++ +A R +Q E+
Sbjct: 1333 EERLAEQQRAEERERLAEVEA----ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388
Query: 1583 LQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKE 1642
+EE+ +++++R+ +++ L Q++E+E++A + + + ++E + R ++
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1445
Query: 1643 VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGT 1702
L+A+E QR EGELQ R + EAQ + Q+ + L+RQV D +
Sbjct: 1446 QLEATER-------QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK-- 1496
Query: 1703 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKA-----LT 1757
++E L +V+ EA + +L + + L ++A
Sbjct: 1497 ---------------RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1541
Query: 1758 ACEHDRQVLQERLDAARQALSEARKQSSSLGEQV----QTLRGEVADLELQRVEAEGQLQ 1813
E RQV A R A +E + + +S E+ ++L+ E + R EAE + Q
Sbjct: 1542 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1601
Query: 1814 QLREVLRQRQEGEAAALNTVQKLQDERRL-LQERLGSLQRALAQLEAEKREVERSALRLE 1872
Q E R R+E E K + RL LQ + Q++LAQ EAEK++ E
Sbjct: 1602 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA------ 1655
Query: 1873 KDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV- 1931
+R A RR K E + +R E AE EL E QRQ+ + AQ
Sbjct: 1656 -EREARRR--GKAEEQAVRQREL-----------------AEQEL-EKQRQLAEGTAQQR 1694
Query: 1932 VVLEQSHSPAQLEVDAQQQQLE-LQQEVERL-RSAQAQTERTLEARERAHRQRVRGLEEQ 1989
+ EQ + E + +QQ + L++E+ RL R A A T++ E A +VR E
Sbjct: 1695 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL--EAELAKVRAEMEV 1752
Query: 1990 VSTLKGQLQQELRRSS 2005
+ K + ++E R +S
Sbjct: 1753 LLASKARAEEESRSTS 1768
Score = 48.9 bits (115), Expect = 5e-05
Identities = 48/216 (22%), Positives = 98/216 (45%), Gaps = 17/216 (7%)
Query: 5 LARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPES 64
LA ++V L IQ +S + +L ++ + A + ++ + + +
Sbjct: 2408 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2467
Query: 65 PVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRL 124
LL T+ L E++ LLQ+ E + Q +A+ ++L A +++L + +
Sbjct: 2468 EQLLQETQALQQSFLSEKDSLLQR-----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2522
Query: 125 EPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYK 184
+ ++E QE + LV E RR+ E + RRK + Q+ +Q++ Q + L
Sbjct: 2523 QQQQME-QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL-------- 2573
Query: 185 KRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI 220
+E Q+L E+ LE+Q HS+++ ++ +
Sbjct: 2574 ---AEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2606
Score = 35.4 bits (80), Expect = 0.57
Identities = 89/418 (21%), Positives = 174/418 (41%), Gaps = 43/418 (10%)
Query: 1606 ERSLQATESELRASQEKISKMKANETKL-EGDKRRLKEVLDASESRTVKLELQ------R 1658
ER ++ E+ + K K E E DK R K + + E +L+
Sbjct: 290 ERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP 349
Query: 1659 RSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVE 1718
+E E + + + +RE Q ++ +R++ LQR V +++AG L E+LN
Sbjct: 350 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG---LCEEQLN------- 399
Query: 1719 ESEGALRDKVRGLTEA-LAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQAL 1777
+++ L+ VR L + Q + + DK + + L +D Q L+ D
Sbjct: 400 QADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF---NDVQTLK---DGRHPQG 453
Query: 1778 SEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQ 1837
+ ++ L E++ +R E +L L+ A Q + L+ Q +T++ LQ
Sbjct: 454 EQMYRRVYRLHERLVAIRTEY-NLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ 512
Query: 1838 DERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV 1897
D ++E + A ++ E + + R L +++++ + R+ D
Sbjct: 513 DLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR------GLHQSIEEFRAKIERARSDEG 566
Query: 1898 RLS-AEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL-Q 1955
+LS A +G L +L+ A + + +A++ LE HS A ++ + L +
Sbjct: 567 QLSPATRGAYRDCLGRLDLQYA---KLLNSSKARLRSLESLHS---FVAAATKELMWLNE 620
Query: 1956 QEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQ---QELRRSSAPFSP 2010
+E E + + + A++ ++ +R LE + +K +LQ L R P P
Sbjct: 621 KEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK-ELQNAGDRLLREDHPARP 677
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 266 bits (680), Expect = 2e-70
Identities = 459/1955 (23%), Positives = 813/1955 (41%), Gaps = 297/1955 (15%)
Query: 110 KYNAVSERLEQALR-LEPGELETQEPRGLVRQSVELRRQLQ--EEQASYRRKL------- 159
+Y + S +Q L+ LE G E + + + ++R QL+ E + +R +L
Sbjct: 984 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA 1043
Query: 160 ----QAYQEGQQRQAQL------VQRLQG---KILQYKK---RCSELEQQLLERSGELEQ 203
Q E Q+ QA++ V RL K+L + L +L G+LEQ
Sbjct: 1044 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1103
Query: 204 QR----------------LRDTEHSQD-LESALIRLEEEQQRSASLAQVNAM------LR 240
R +R T+ +++ L + +L+E Q A+L ++ A LR
Sbjct: 1104 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1163
Query: 241 EQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLW 300
Q + AL +++R R ++ R+ R E ++LL W
Sbjct: 1164 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERV--------AQLLERW 1215
Query: 301 RQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAES-RAEAALEK 359
+ V+ ++V+ +R+L QLG +L + G L R E +A +
Sbjct: 1216 QAVLA----QTDVR---QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1268
Query: 360 QALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQV 419
QA+ + +EQ + + ++ Q + + + EL L + + + +
Sbjct: 1269 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK 1328
Query: 420 NKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADA 479
+ E++ +QE L T E T +Q + SE+ ++ ER A+
Sbjct: 1329 KPKVQSGSESV----IQEYVDLRTHYSELTTLT----SQYIKFISETLRRMEEEERLAEQ 1380
Query: 480 SNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMR 539
QR R + +R + A + + A + ++++Q + +R
Sbjct: 1381 ----------QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430
Query: 540 GRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANE 599
R EA+ D ++ ++R+++E+LQ+LR ++ +QA + R A E
Sbjct: 1431 -REEAAVD-----------AQQQKRSIQEELQQLRQSSEAEIQA---------KARQA-E 1468
Query: 600 LLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
R + + ++V + Q E ++R + + LR + + E ++ A ++ R+RR
Sbjct: 1469 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1528
Query: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRA--TLQRDMLQAEKAEVAEALTKAEAGR 717
+++ ++ Q E + + K E RA L+ LQAE+AE + E R
Sbjct: 1529 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1588
Query: 718 VELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAE 777
T R+ EA LQ + + L + + + VAQL EE R+ Q +
Sbjct: 1589 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE----RRAQQQ 1644
Query: 778 QEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLA 837
EA AREE ER EL Q A + L L+ E AQ Q+ LA
Sbjct: 1645 AEAERAREEAER--ELERWQLKANEALRLRLQAEEVAQ-----------------QKSLA 1685
Query: 838 QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKE-------HAGLAVQLVAAER 890
Q E++ E+A REA+R+ +A E+A R++E +E G A Q +AAE+
Sbjct: 1686 QAEA-----EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1740
Query: 891 EGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAG 950
E L E + +++ LE L +QR+ A +R++LEAE + E L A
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1800
Query: 951 LRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELE 1010
++ +T EK+ E A + + EA R + A E QR E++AA + E
Sbjct: 1801 AEEESRSTSEKSKQRLEAEAGRFRELAEEAA---RLRALAEEAKRQRQLAEEDAARQRAE 1857
Query: 1011 AERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLL--LAESEKQQALSLKE 1068
AER E+L A EA + + EIA ++E + L LAE E Q L+E
Sbjct: 1858 AERVLA--------EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1909
Query: 1069 S---EKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQRE 1125
K + E+L R + + E+ERQK + Q R + E+ L+A E
Sbjct: 1910 QAAQHKADIEERLAQLRKASDS---ELERQKGLVEDTLRQRRQ----VEEEILALKASFE 1962
Query: 1126 EAAAAHAQ---EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
+AAA A+ E+ R++ A D + ++ EA R QL E+ R RRE E +
Sbjct: 1963 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-QLAAEEERR---RREAEERVQ 2018
Query: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERI-SLKLANE 1241
K ++E QR+ A E E E L+ EE R ++AE E L+LA E
Sbjct: 2019 KSLAAEEEAARQRKAALE----------EVERLKAKVEEARRLRERAEQESARQLQLAQE 2068
Query: 1242 DKEQKLALLEEART-AVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLG 1300
+++L E+A AV ++ EL+ LQ+ + + R E + RR + + +
Sbjct: 2069 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2128
Query: 1301 RELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQEL-QVAQRKLQEQEGEF 1359
RE A+ + ++ ER ++ + + Q + +A+ E +R+E Q A R+ Q ++
Sbjct: 2129 REAAQSRRQVEEAERLKQSAEEQA----QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2184
Query: 1360 RTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAEL 1419
R ++ +E+ + +Q L +E +L R L+L + + L+ EL
Sbjct: 2185 RQKQAAD-AEMEKHKKFAEQTLRQKAQVEQELTTLR-------LQLEETDHQKNLLDEEL 2236
Query: 1420 ARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPST 1479
R++ + A Q RS + L R
Sbjct: 2237 QRLKAEATEAARQ----RSQVEEELFSVR------------------------------- 2261
Query: 1480 LECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRE--RDELRTQTSALNR 1537
++ S+ + A + A D + + L+E ++++ E R + Q +A R
Sbjct: 2262 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2321
Query: 1538 QLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRA 1597
QLAE + + A + +K A E R + L Q ELA +E RR + ++
Sbjct: 2322 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA--QEQARRLQEDKEQ 2379
Query: 1598 TLDQVATLERSLQAT-------ESELRASQEK----ISKMKANETKLEGDKRRLKEVLDA 1646
Q+A + Q T + E+ A E+ +++M + + E D +R ++ +
Sbjct: 2380 MAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2439
Query: 1647 SESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLT 1706
+ + EL + +Q + + A+ L++ + L+R+ + +A LQL
Sbjct: 2440 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQL- 2498
Query: 1707 VERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNST---RDKNLHLQKALTACEHDR 1763
K EE + ++++ T+AL QS S + R++ + +KA
Sbjct: 2499 ---------KSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL-----E 2544
Query: 1764 QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQ 1823
Q+ Q+ + A+Q E ++Q + ++ Q L VA +E EA + + E +R++Q
Sbjct: 2545 QLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASME----EARRRQHEAEEGVRRKQ 2597
Query: 1824 EGEAAALNTVQKLQDERR----LLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALR 1879
E +Q+L+ +RR LL E L+ L LE + R + + +VA
Sbjct: 2598 E-------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2650
Query: 1880 RTLDK---------VEREKLRSHEDTVR-LSAEKGRLDRTLTGAELE-LAEAQRQIQQLE 1928
+TL E E S + R +SA++ + L+ EL+ LA+ + +L
Sbjct: 2651 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2710
Query: 1929 AQVVV---LEQSHSPAQLEVDAQQQQLELQQEVER 1960
+ V L+ S A L + A ++L + ++R
Sbjct: 2711 RREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQR 2745
Score = 263 bits (673), Expect = 1e-69
Identities = 357/1544 (23%), Positives = 644/1544 (41%), Gaps = 172/1544 (11%)
Query: 543 EASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRS-ANELL 601
EA++ L LR Q + AL ++L+ ++ + Q H + EV+R R +LL
Sbjct: 1153 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1212
Query: 602 SREKSNLAHSLQVAQQQAEEL----RQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARV 657
R ++ LA + V Q++ E+L R RE L+ R R E+ Q + D V
Sbjct: 1213 ERWQAVLAQT-DVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1271
Query: 658 RRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGR 717
R +L + LE++E EK E + K
Sbjct: 1272 REQLRQEQALLEEIER--------------------------HGEKVEECQRFAKQYINA 1305
Query: 718 V---ELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQL-----------E 763
+ EL+L K + E + K+ + +ES+ Q+ +DL ++L
Sbjct: 1306 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1365
Query: 764 EEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLP 823
E ++ +R AEQ+ EE+ERL E+ E RQ E + QA+ ++
Sbjct: 1366 ETLRRMEEEERLAEQQRA---EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1422
Query: 824 TLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEA----LERAAREKEALAKEHA 879
++ E + +E +Q ++EL+Q R+ ++ +++A E A R + + +E
Sbjct: 1423 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1482
Query: 880 GLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEAR---REQLEAEGQA 936
+ +QL A ER+ E LR E E + Q + +L + Q + + +
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1542
Query: 937 LLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAE---------------REAQ 981
L ++ E A +Q+ + E+ L E ++L QAE R A+
Sbjct: 1543 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602
Query: 982 ASLREQRAAHEEDLQRLQREKE------AAWRELEAERAQLQSQLQREQEELLARLEA-- 1033
A L+ +RA+ E +L+R + A RE RAQ Q++ +R +EE LE
Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662
Query: 1034 --EKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE 1091
E L + A + + + L AE+EKQ+ + +E+ + +E+ + LA LE
Sbjct: 1663 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1722
Query: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHA---QEVRRLQEQARDLGKQ 1148
+RQ + ++Q A EL LRA+ E+ +E+ RLQ +A ++
Sbjct: 1723 KQRQLAEGTAQQRL------AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1776
Query: 1149 RDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLR---ESQEGREVQRQEAGELRRSL 1205
R E ++R ++ +L ++ E K + E++ GR + E R+L
Sbjct: 1777 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1836
Query: 1206 GEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELR 1265
E AK + L + +A ++AE+ER+ +KLA + EA K E+
Sbjct: 1837 AEEAKRQRQLAEED----AARQRAEAERVLA--------EKLAAIGEATRL--KTEAEIA 1882
Query: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETL 1325
+E E RL RR ++ Q + L+ + + A+++ RLA +A
Sbjct: 1883 LKEKEAENERL--RRLAEDEAFQRRRLEEQ---AAQHKADIEERLAQLRKASDSELERQK 1937
Query: 1326 GLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA-RGTEKQQLDHA 1384
GL + L+ +E L+ + K + E R+ + E+ R E+ +L+ A
Sbjct: 1938 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1997
Query: 1385 RGLELKLEAARA--EAAE-LGLRLSAAEGRAQGLEAELARVE-VQRRAAEAQLGGLRSAL 1440
R +L E R EA E + L+A E A+ +A L VE ++ + EA+ R+
Sbjct: 1998 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQ 2057
Query: 1441 RRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASP 1500
L A A + + A A E TL+ G A
Sbjct: 2058 ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ-ELQQTLQQEQSVLDQLRGEA------ 2110
Query: 1501 DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNR--QLAEMEAERDSATSRARQLQK 1558
EA R A E + A+RE + R Q R Q AE +A+ + A + +
Sbjct: 2111 ----EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2166
Query: 1559 AVAESEEARRSVDGRLS-----GVQAELALQEESVRRSERERRATLDQVATLERSLQATE 1613
AE E ARR+ + + AE+ ++ ++ R++ ++ TL L+ T+
Sbjct: 2167 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2226
Query: 1614 SELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLS 1673
+ E++ ++KA T+ + +++E L + + +L + +E E L L
Sbjct: 2227 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE--NRALILR 2284
Query: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGA----LAKVEE-SEGALRDKV 1728
D++ + LQ+ + + +QVA+ + RL LA+ +E L++K+
Sbjct: 2285 DKDNTQRFLQEEAEKM-KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2343
Query: 1729 RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQ---ERLDAARQALSEARKQSS 1785
+ + EA + + + K L ++A E Q+ Q E ++ L R++
Sbjct: 2344 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2403
Query: 1786 SLGEQVQTLRGEVADLELQRVEAEGQLQQLR-------EVLRQRQEGEAAALNTVQKLQD 1838
+ + + L+ VA++ + AE Q+ R E L + + + VQ L+
Sbjct: 2404 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2463
Query: 1839 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR 1898
+R+ L+ A+A+LE EK ++++ A L+ + V++E+L
Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQ------ 2513
Query: 1899 LSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV 1958
E L ++ + L + +R I+Q +A++ L Q ++ +QQ+ + Q E
Sbjct: 2514 ---ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570
Query: 1959 ERLRSAQAQTERTLEARERAH--RQRVRGLEEQVSTLKGQLQQE 2000
ER R + EAR R H + VR +E++ L+ Q +Q+
Sbjct: 2571 ERQRLVASME----EARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2610
Score = 234 bits (597), Expect = 6e-61
Identities = 425/1785 (23%), Positives = 742/1785 (41%), Gaps = 230/1785 (12%)
Query: 116 ERLEQALRLEPGELETQEP-----RGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQA 170
E + +L+ + E Q+P R +R + E+ +LQ+ +++ ++E R A
Sbjct: 1153 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE---RVA 1209
Query: 171 QLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI---RLEEEQQ 227
QL++R Q + Q R ELEQ ++LR S D A + R +EQ
Sbjct: 1210 QLLERWQAVLAQTDVRQRELEQL---------GRQLRYYRESADPLGAWLQDARRRQEQI 1260
Query: 228 RSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCR----------KELEHREAA 277
++ LA A+ REQL Q QAL E+I + C+ K+ E +
Sbjct: 1261 QAMPLADSQAV-REQLRQ----EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT 1315
Query: 278 WRRE-----------------EESFNAYFS--NEHSRLLLLWRQVVGFRRLVSEV--KMF 316
++ + E Y +S L L Q + F +SE +M
Sbjct: 1316 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKF---ISETLRRME 1372
Query: 317 TERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVL 376
E L + R A EA L L A ++A+A E++A +L+++++++V+
Sbjct: 1373 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA---KELQQRMQEEVV 1429
Query: 377 REKDLA---QQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL 433
R ++ A QQQ +S ++ + +E + K + + E+ ++ + E + +
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE-----EEIRVV 1484
Query: 434 RLQEQAALETEDG-EGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRT 492
RLQ +A G EG Q LR A+ E+ Q ++ A+ ++ S ++
Sbjct: 1485 RLQLEATERQRGGAEGELQALRARAE------EAEAQKRQAQEEAERLRRQVQDESQRKR 1538
Query: 493 PSPPRRSSPGRGRSPR-RGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGT 551
+ +S + + R A L L +R Q + R R + L
Sbjct: 1539 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR-QVQVALETA 1597
Query: 552 LRKQLSDSESERRALEE---QLQR-LRDKTDGAMQAHEDAQREVQR---LRSANELLSRE 604
R ++ +S+R + E QL+R L+++ Q E+A+R Q+ A E RE
Sbjct: 1598 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1657
Query: 605 ------KSNLAHSLQVAQQQAEELRQEREKLQAA----QEELRRQRDRLEEEQEDAVQDG 654
K+N A L++ QAEE+ Q++ QA +EE R+ R + +E AV+
Sbjct: 1658 LERWQLKANEALRLRL---QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1714
Query: 655 ARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE 714
+ELE+ + E +R +EL+ +R + QR +L+ E A + A
Sbjct: 1715 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1774
Query: 715 AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQ------LEEEKSA 768
R ELE + K+RAE L SK A ES + + RL A+ L EE +
Sbjct: 1775 QKRQELEAELAKVRAEMEVLL--ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1832
Query: 769 LQG------RQRQ-AEQEATVAREEQERL--EELRLEQEVARQGLEG--SLRVAEQAQEA 817
L+ RQRQ AE++A R E ER+ E+L E R E +L+ E E
Sbjct: 1833 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1892
Query: 818 LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR-REAQRQVEALERAAREKEALAK 876
L + +R +L+EQ AQ + R +L +A E +RQ +E R++ + +
Sbjct: 1893 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1952
Query: 877 EHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARRE-QLEAEGQ 935
E L A L E R+R E S ++ A+LEA R+ QL AE
Sbjct: 1953 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRS-----KEQAELEAARQRQLAAE-- 2005
Query: 936 ALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL 995
+E E Q+ +A +E+A+ ++ +++ + + + + + R + A +E
Sbjct: 2006 -----EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2060
Query: 996 QRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLL 1055
++LQ +EAA + L+AE +Q++++EL ++ L +E + L Q R E
Sbjct: 2061 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL-------QQTLQQEQSVLDQLRGE---- 2109
Query: 1056 AESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTS 1115
AE+ ++ A +E+ A E R E ER K+ A+ Q Q R+ A
Sbjct: 2110 AEAARRAAEEAEEARVQAEREAAQSRRQVE-----EAERLKQSAEE-QAQARAQAQAAAE 2163
Query: 1116 ELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRR 1175
+LR A++E A A A++ Q+QA D ++ + AE+ Q +E LR
Sbjct: 2164 KLRK-EAEQEAARRAQAEQAALRQKQAADAEMEKHK--KFAEQTLRQKAQVEQELTTLRL 2220
Query: 1176 ELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERIS 1235
+L E + E + + EA E R + +E ++R EEL + E+E +
Sbjct: 2221 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2280
Query: 1236 LKLANEDKEQKLALLEEARTA--VGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLD 1293
L L ++D Q+ L EEA V +EA L QE R R A +L + R + +
Sbjct: 2281 LILRDKDNTQRF-LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2339
Query: 1294 SENTRLGRELAELQGRLAL----GERAEKESRR--------------ETLGL-------R 1328
E + +E L+ L E A++++RR ET G R
Sbjct: 2340 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2399
Query: 1329 QRLLKGEASLEVMR---QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHAR 1385
QR L+ A E ++ E+ AQ + +E FR + + L ++++ +
Sbjct: 2400 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2459
Query: 1386 GLELKLEAARAEAAELGLRLSAAEGRAQGLEAE-----LARVEVQRRAAEAQLGGLRSAL 1440
LE++ + + +A L ++ E + L+ E L E+Q E L ++
Sbjct: 2460 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2519
Query: 1441 RRGLGLGRAPSPAPRPVPGSPAR------DAPAEGSGEGLNSPSTLECSPGSQPPSPGPA 1494
+ L + R + A+ D A+ + L + Q A
Sbjct: 2520 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK--AQQLREEQQRQQQQMEQERQRLVA 2577
Query: 1495 TSPASPDLDPEAVRGALR--EFLQELRSAQRERDE-LRTQTSALNRQLAEMEAERDSATS 1551
+ + EA G R E LQ+L +R+++E L + L QL +E + +A +
Sbjct: 2578 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2637
Query: 1552 RARQLQKAVAESEEARRSVDGRLSGVQAELALQE--ESVRR---SERERRATLDQVATLE 1606
+ ++ + + + + L G AE + + +RR ++R + A + L+
Sbjct: 2638 HSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2697
Query: 1607 RSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDA-SESRTVKLELQRRSLEGEL 1665
R Q + +++++ + L+G +L A +E +V LQR+ L
Sbjct: 2698 RLAQG-----HTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS--- 2749
Query: 1666 QRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR 1725
+ L L + +A + L D V + +R + VK G + L+ L E + +
Sbjct: 2750 PGTALILLEAQAASGFLLDPVRN-RRLTVNEAVKEGVVG---PELHHKLLSAERAVTGYK 2805
Query: 1726 DKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERL 1770
D G +L Q+ +QK L EH ++L+ ++
Sbjct: 2806 DPYTGQQISLFQA-------------MQKGLIVREHGIRLLEAQI 2837
Score = 220 bits (560), Expect = 1e-56
Identities = 342/1419 (24%), Positives = 607/1419 (42%), Gaps = 206/1419 (14%)
Query: 75 SLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEP 134
+L ++EE +L +Q+ + + LA+ A ++ A ++ QA R E EL+ +
Sbjct: 1367 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER-EAKELQQRMQ 1425
Query: 135 RGLVRQ------SVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQR------------- 175
+VR+ + + +R +QEE R+ +A + + RQA+ +R
Sbjct: 1426 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1485
Query: 176 ------------LQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLE 223
+G++ + R E E Q + E E+ R + + SQ A + L
Sbjct: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1545
Query: 224 EEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTR-CRKELEHREAAWRREE 282
+ A A+ + L++ + +R+ + R + LE + + E
Sbjct: 1546 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1605
Query: 283 ESFNAYFSNEHSRL-LLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR--TSRAVQEAG 339
+S A F+ + ++L L + V +L E + ++ Q E AR R ++
Sbjct: 1606 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ---QAEAERAREEAERELERWQ 1662
Query: 340 LGLSTGLRLAESRAEAALEKQALLQAQLEEQ-------------LRDKVLREKDLAQQQM 386
L + LRL +AE ++++L QA+ E+Q ++ +R+++LA+Q++
Sbjct: 1663 LKANEALRL-RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1721
Query: 387 QSDLDKADLSARVTELGLAVK----RLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALE 442
+ A+ +A+ LA + RL + + +Q + L E+L RLQ +AA
Sbjct: 1722 EKQRQLAEGTAQQR---LAAEQELIRLRAETEQGEQQRQLLEEELA-----RLQREAAAA 1773
Query: 443 TEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPG 502
T+ + L+ L + +E V L+ R + S S S QR + G
Sbjct: 1774 TQKRQELEAELAKVR------AEMEVLLASKARAEEESR-STSEKSKQRL-----EAEAG 1821
Query: 503 RGRSPRRGPSPACSDSSTL-ALIHSALHKRQLQVQDM-RGRYEASQDLLG---------- 550
R R +++ L AL A +RQL +D R R EA + L
Sbjct: 1822 RFRE-------LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1874
Query: 551 -------TLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANEL-LS 602
L+++ +++E RR E++ + R + A Q D + + +LR A++ L
Sbjct: 1875 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1934
Query: 603 REKSNLAHSLQVAQQQAEE---LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
R+K + +L+ +Q EE L+ EK A + EL + R+ ED ++ +
Sbjct: 1935 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1994
Query: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVE 719
E R RQL E +R A+E V+ A ++ E+ E +A K E R
Sbjct: 1995 EAARQ-RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA--KVEEAR-- 2049
Query: 720 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQE 779
R E + Q+S +L E+ AQ +L Q EE+ A +Q++ E +
Sbjct: 2050 --------RLRERAEQESARQLQLAQEA-AQKRL-------QAEEKAHAFAVQQKEQELQ 2093
Query: 780 ATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ-EALEQQLPTLRHER-SQLQEQLA 837
T+ ++EQ L++LR E E AR+ E + QA+ EA + + ER Q E+ A
Sbjct: 2094 QTL-QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2152
Query: 838 QLSRQLSGREQEL-EQARREAQRQVEALERAAREKEA---------------------LA 875
Q Q ++L ++A +EA R+ +A + A R+K+A +
Sbjct: 2153 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2212
Query: 876 KEHAGLAVQLVAAEREGRTLSEEATRLRLE-------KEALEGSLFEVQRQLAQLEARRE 928
+E L +QL + + L EE RL+ E + +E LF V+ Q+ +L +
Sbjct: 2213 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2272
Query: 929 QLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQR 988
++EAE +AL+L + T + + + + + AQ+ + + A+ L +QR
Sbjct: 2273 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR 2332
Query: 989 AAHEEDL-QRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQ 1047
A E+ L +++Q +EA + EAE Q Q +L +EQ RL+ +KE++++++A Q
Sbjct: 2333 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR---RLQEDKEQMAQQLAEETQ 2389
Query: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDR 1107
L E+E+Q+ L E +A +E+L + +A +S R + DAQ ++Q
Sbjct: 2390 GFQRTL---EAERQRQL-----EMSAEAERL---KLRVAEMSRAQARAEEDAQRFRKQAE 2438
Query: 1108 STVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLE 1167
L R A +E+ E++R Q +AE LR + LE
Sbjct: 2439 EIGEKLH---RTELATQEKVTLVQTLEIQRQQSD------------HDAERLREAIAELE 2483
Query: 1168 DARDGLRRELLEAQRKLRESQEGREVQ-RQEAGELRRS-LGEGAKEREALRRSNEELRSA 1225
++ L++E Q K E Q ++ Q QE L++S L E + R +E
Sbjct: 2484 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2543
Query: 1226 VKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQEL 1285
+ + E + E+++++ +E+ R + E R E E + ELQ+L
Sbjct: 2544 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2603
Query: 1286 ----RRQMKMLDSENTRLGR--ELAELQGRLALGE----RAEKESRRETLGLRQRLLKGE 1335
R+Q ++L EN RL +L E Q R AL A + + +TL + L G
Sbjct: 2604 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGP 2663
Query: 1336 ASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEAR 1374
A+ +RK+ Q R +E +L + E R
Sbjct: 2664 AAEAEPEHSFDGLRRKVSAQ----RLQEAGILSAEELQR 2698
Score = 195 bits (496), Expect = 3e-49
Identities = 323/1344 (24%), Positives = 558/1344 (41%), Gaps = 216/1344 (16%)
Query: 746 ESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV------AREEQERL-EELRLEQE 798
E AQ++ R +++L++ + L+ + + + ARE +R+ E+ + + E
Sbjct: 1000 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAE 1059
Query: 799 VARQGLEGSLRVAEQAQE--ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE 856
V G +G R++ +A++ AL + P RS+L+ L +L + S L E
Sbjct: 1060 VEGLG-KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS-----LSAIYLE 1113
Query: 857 AQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEV 916
+ + + R + E + + H EE + E +A+ +L E+
Sbjct: 1114 KLKTISLVIRGTQGAEEVLRAH------------------EEQLK---EAQAVPATLPEL 1152
Query: 917 QRQLAQLEARREQLEAEGQALLLAKETLTG-ELAGLRQQIIATQEKASLDKELMAQKLVQ 975
+ A L+ R Q EA+ ++ L G + G R Q Q D E+ +
Sbjct: 1153 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ----QRHGERDVEVERWR--- 1205
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQ------SQLQREQEEL-- 1027
ER AQ R Q + D++ QRE E R+L R +R QE++
Sbjct: 1206 -ERVAQLLERWQAVLAQTDVR--QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1262
Query: 1028 --LARLEAEKEELSEEIAALQQERDEGLLLAESE---KQQALSLKESEKTALSEKLMGTR 1082
LA +A +E+L +E A L++ G + E + KQ ++K+ E
Sbjct: 1263 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL----------- 1311
Query: 1083 HSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQA 1142
L T ++E A+ + Q S ++ E DLR E +Q ++ + E
Sbjct: 1312 -QLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1368
Query: 1143 RDLGKQRDSCLREAEELRTQLRLLEDARDGLR--------------RELLEAQRKLRESQ 1188
R + ++ ++ E R +L +E A + R RE E Q++++E
Sbjct: 1369 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1428
Query: 1189 EGREVQRQEAGELRRSLGEGAKEREALRRSNE-ELRSAVKKAES-ERISLKLANEDKEQK 1246
RE +A + +RS+ E E + LR+S+E E+++ ++AE+ ER L++ E + +
Sbjct: 1429 VRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1485
Query: 1247 LAL--LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELA 1304
L L E R E LR +E E + +A+ E + LRRQ++ E+ R +
Sbjct: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQRKRQAEV 1542
Query: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER 1364
EL R+ +AE E+ RE +QR L+ +LE +R + + A+R+L++ E E R R
Sbjct: 1543 ELASRV----KAEAEAARE----KQRALQ---ALEELRLQAEEAERRLRQAEVE---RAR 1588
Query: 1365 RLLGSLEEARGTEKQQLDHARG--------LELKLEAARAEAAELGLRLSAAEGRAQGLE 1416
++ +LE A+ + + +L R LE L+ A+L R A Q E
Sbjct: 1589 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL--REEAERRAQQQAE 1646
Query: 1417 AELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNS 1476
AE AR E +R QL ALR L A A AE E
Sbjct: 1647 AERAREEAERELERWQLKA-NEALRLRL-------QAEEVAQQKSLAQAEAEKQKEEAER 1698
Query: 1477 PSTLECSPGSQPPSPGPATSPASPDLDPEA--VRGALREFL---QELRSAQRERDELRTQ 1531
+ G A +L+ + G ++ L QEL + E ++ Q
Sbjct: 1699 EARRR---GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1755
Query: 1532 TSALNRQLAEMEAERDSATSRARQLQKAVAE---------SEEARRSVDGRLSGVQAELA 1582
L +LA ++ E +AT + ++L+ +A+ + +AR + R + +++
Sbjct: 1756 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1815
Query: 1583 LQEESVR-RSERERRATLDQVAT-LERSLQATESELRASQEKISKMKANETKLEGDKRRL 1640
L+ E+ R R E A L +A +R Q E + + + ++ A + G+ RL
Sbjct: 1816 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1875
Query: 1641 KE----VLDASESRTVKLE-------LQRRSLEGELQRSRLGLSDREAQAQALQDR---- 1685
K L E+ +L QRR LE + + + + +R AQ + D
Sbjct: 1876 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1935
Query: 1686 ----VDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSAS 1741
V+ RQ E + L+ + E+ A++E G +R + Q A
Sbjct: 1936 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ--AE 1993
Query: 1742 LNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADL 1801
L + R + L ++ E R+ +ER+ + A EA +Q + E+V+ L+ +V +
Sbjct: 1994 LEAARQRQLAAEE-----ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2048
Query: 1802 ELQRVEAEG----QLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQL 1857
R AE QLQ +E ++R + E A +Q + + LQ+ L Q L QL
Sbjct: 2049 RRLRERAEQESARQLQLAQEAAQKRLQAEEKA--HAFAVQQKEQELQQTLQQEQSVLDQL 2106
Query: 1858 EAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELEL 1917
E R+A E+ RV + ERE +S ++
Sbjct: 2107 RGEAEAARRAAEEAEEARV-------QAEREAAQSRR---------------------QV 2138
Query: 1918 AEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARER 1977
EA+R Q E EQ+ + AQ + A++ + E +QE R A+ R +A +
Sbjct: 2139 EEAERLKQSAE------EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD- 2191
Query: 1978 AHRQRVRGLEEQVSTLKGQLQQEL 2001
A ++ + EQ K Q++QEL
Sbjct: 2192 AEMEKHKKFAEQTLRQKAQVEQEL 2215
Score = 188 bits (477), Expect = 5e-47
Identities = 438/1879 (23%), Positives = 754/1879 (40%), Gaps = 272/1879 (14%)
Query: 271 LEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR 330
+ H AA+ EE F + F + +LW Q + F+ + K E D + G
Sbjct: 322 MRHHTAAF--EERRFPSSFEE----IEILWSQFLKFKEMELPAK---EADKNRSKGIYQS 372
Query: 331 TSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLR----EKDLAQQQM 386
AVQ L + G + E A+L+ E+QLR + R ++ + + QM
Sbjct: 373 LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILER--EKQLRSEFERLECLQRIVTKLQM 430
Query: 387 QSDLDKADLSARVTELGLAVKRLEKQNLEK--DQVNKDLTEKLEALESLRLQEQAALETE 444
++ L + L+ L V+ L + + +V +DL +K +++ L +
Sbjct: 431 EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL-DKADSMIRLLFNDV------ 483
Query: 445 DGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRG 504
QTL+D V A + +LR +G +P + +
Sbjct: 484 ------QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG--VAAPATQVAQVTL 535
Query: 505 RSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERR 564
+S +R P + STL + L V++ + R + ++ G + R
Sbjct: 536 QSVQRRPE---LEDSTLRYLQDLL----AWVEENQHRVDGAE--WGVDLPSVEAQLGSHR 586
Query: 565 ALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQ 624
L + ++ R K + A ++ Q + + L R A L ++ + L
Sbjct: 587 GLHQSIEEFRAKIERARS--DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 644
Query: 625 EREKLQAAQEELRRQRDRLEEE-----------QEDAVQDGARVRRELERSHRQLEQLEG 673
+ AA +EL ++ EEE + + + RELE +++++L+
Sbjct: 645 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 704
Query: 674 KRSVLAKELVEVREALS--RATLQRD---MLQAEKAEVAEALTKAEAGRVELELSMTKLR 728
L +E R + +A LQ MLQ EA K A + + +
Sbjct: 705 AGDRLLREDHPARPTVESFQAALQTQWSWMLQL--CCCIEAHLKENAAYFQFFSDVREAE 762
Query: 729 AEEASLQDSLSKLSALNESLAQDKL-----DLNRLVAQLEEEKSALQGRQRQAEQEATVA 783
+ LQ++L + + + S +L D QL E K L G ++A+ A V
Sbjct: 763 GQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK--AVVQ 820
Query: 784 REEQERLEELR----LEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQ-LAQ 838
+ + +R L + +E ++ ++ Q Q + S E +
Sbjct: 821 LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 880
Query: 839 LSRQLSGREQELEQARREAQRQVEALERAARE-----KEALAKEHAGLAVQLVAAEREG- 892
+ + QE ++A + Q +AL + K LA + VQL+ +
Sbjct: 881 VCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT 940
Query: 893 -RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 951
RTL E R L L F Q A ++L AE + G +
Sbjct: 941 FRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREY---------GSCSHH 991
Query: 952 RQQIIATQEKASLDKELMAQKLVQAEREAQASLR--EQRAAHEEDLQRLQRE--KEAAWR 1007
QQ++ + E+ + +E Q+ + ++ + L E R H L L +E +E A R
Sbjct: 992 YQQLLQSLEQGA-QEESRCQRCISELKDIRLQLEACETRTVHRLRLP-LDKEPARECAQR 1049
Query: 1008 ELEAERAQLQ--------SQLQREQEELLARLEAE------KEELSEEIAALQQERDEGL 1053
E ++AQ + ++L E E++LA E + EL + L+Q R
Sbjct: 1050 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1109
Query: 1054 LLAESEKQQALSLK-----ESEKTALSEKLMGTRHSLATISLEMERQK---RDAQSRQEQ 1105
+ E K +L ++ E A E+L + AT+ E+E K + +++ E
Sbjct: 1110 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEA 1168
Query: 1106 DRSTVNALTSELRDLRAQREEAAAAHAQ---EVRRLQEQARDLGK-------QRDSCLRE 1155
+ T +AL ELR + E H + EV R +E+ L + Q D RE
Sbjct: 1169 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRE 1228
Query: 1156 AEELRTQLRLLEDARDGLRRELLEAQRK--------LRESQEGREVQRQEAGELRRSLGE 1207
E+L QLR ++ D L L +A+R+ L +SQ RE RQE L
Sbjct: 1229 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERH 1288
Query: 1208 GAKEREALRRSNEELRSAVKKAESERISLKLANED--KEQKLALLEEARTAVGKEAGELR 1265
G K E R + + + +A+K E + ++ K E K ++ +V +E +LR
Sbjct: 1289 GEKVEECQRFAKQYI-NAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR 1347
Query: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLG-RELAELQGRLALGERAEKESRRET 1324
T E+ + + + E R+M+ E RL ++ AE + RLA E A ++ R+
Sbjct: 1348 THYSELTTLTSQYIKFISETLRRME----EEERLAEQQRAEERERLAEVEAALEKQRQLA 1403
Query: 1325 LGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHA 1384
Q + E + ++Q +Q + +E + + ++R S++E E QQL +
Sbjct: 1404 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR----SIQE----ELQQLRQS 1455
Query: 1385 RGLELKLEAARAEAAELG-LRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRG 1443
E++ +A +AEAAE LR+ E + + +L E QR AE +L LR+
Sbjct: 1456 SEAEIQAKARQAEAAERSRLRI---EEEIRVVRLQLEATERQRGGAEGELQALRARAEE- 1511
Query: 1444 LGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLD 1503
+ A+ A+ E L + SQ + +
Sbjct: 1512 ----------------AEAQKRQAQEEAERLRR----QVQDESQRKRQAEVELASRVKAE 1551
Query: 1504 PEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAES 1563
EA R E + A + +ELR Q R+L + E ER ARQ+Q A+
Sbjct: 1552 AEAAR--------EKQRALQALEELRLQAEEAERRLRQAEVER------ARQVQVAL--- 1594
Query: 1564 EEARRSVDGRLSG---------VQAELALQEESVR----RSERERRATLDQVATLERSLQ 1610
E A+RS + L Q E +LQEE V R E ERRA Q A ER+ +
Sbjct: 1595 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA--QQQAEAERARE 1652
Query: 1611 ATESELR-------------------ASQEKISKMKANETKLEGD---KRRLKEVLDASE 1648
E EL A Q+ +++ +A + K E + +RR K A
Sbjct: 1653 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1712
Query: 1649 SRTV---KLELQRRSLEG----------ELQRSRLGLSDREAQAQALQDRVDSLQRQVAD 1695
R + +LE QR+ EG EL R R E Q Q L++ + LQR+ A
Sbjct: 1713 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1772
Query: 1696 SEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE----ALAQSSASLNSTRDKNLH 1751
+ K L+ + ++ + + S+ ++ R +E L + ++
Sbjct: 1773 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1832
Query: 1752 LQKALTACEHDRQVLQERLDAARQALSEAR---KQSSSLGEQVQTLRGEVADLELQRVEA 1808
L+ + RQ+ +E DAARQ R ++ +++GE + L+ E A++ L+ EA
Sbjct: 1833 LRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATR-LKTE-AEIALKEKEA 1888
Query: 1809 EGQLQQLREVLRQRQEGEAAALNTVQKLQDERRL-LQERLGSLQRAL-AQLEAEKREVE- 1865
E E LR+ E EA +++ + + ++ERL L++A ++LE +K VE
Sbjct: 1889 E------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1942
Query: 1866 --RSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQ 1923
R ++E++ +AL+ + +K K + R+ + R+ AELE A QRQ
Sbjct: 1943 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-QRQ 2001
Query: 1924 I--QQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQ 1981
+ ++ + E+ E +A +Q+ +EVERL+ A+ E RERA ++
Sbjct: 2002 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK---AKVEEARRLRERAEQE 2058
Query: 1982 RVRGLEEQVSTLKGQLQQE 2000
R L+ + +LQ E
Sbjct: 2059 SARQLQLAQEAAQKRLQAE 2077
Score = 154 bits (389), Expect = 8e-37
Identities = 349/1516 (23%), Positives = 595/1516 (39%), Gaps = 229/1516 (15%)
Query: 550 GTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSA-----NELLSRE 604
G + + L ++S R L +Q L+D G E R V RL E R
Sbjct: 463 GEVERDLDKADSMIRLLFNDVQTLKD---GRHPQGEQMYRRVYRLHERLVAIRTEYNLRL 519
Query: 605 KSNLAH-SLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELER 663
K+ +A + QVAQ + +++ E + L+ +EE Q DGA +L
Sbjct: 520 KAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV--DGAEWGVDLPS 577
Query: 664 SHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ-AEKAEVAEALTKAEAGRVELEL 722
QL G L + + E R + RA L A + + L GR++L+
Sbjct: 578 VEAQL----GSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCL-----GRLDLQY 628
Query: 723 SMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV 782
+ L + +A L+ SL L + + ++ + LN + EEE+ R A
Sbjct: 629 AKL-LNSSKARLR-SLESLHSFVAAATKELMWLN----EKEEEEVGFDWSDRNTNMTA-- 680
Query: 783 AREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 842
++E L E E+ + ++ ++ PT+ ++ LQ Q + + +
Sbjct: 681 ---KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 737
Query: 843 LSGREQELEQAR---------REAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGR 893
E L++ REA+ Q++ L+ A R K + + ++ + + +
Sbjct: 738 CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQ-- 795
Query: 894 TLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQ 953
+E +L K L G L + + + QL+ R G+ LLA +
Sbjct: 796 ---DEKEQLNEYKGHLSG-LAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDY--------K 843
Query: 954 QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013
Q+ T K ++ Q + + + W+ L +
Sbjct: 844 QVEVTVHKG------------------------------DECQLVGPAQPSHWKVLSSSG 873
Query: 1014 AQ--------LQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS 1065
++ L +E +E + RLEA+ + L L + LLA ++ +
Sbjct: 874 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKS--LLAWQSLRRDVQ 931
Query: 1066 LKESEKTALSEKLMGTRHSLATISLEME-----RQKRDAQSRQEQDRSTVNALTSELRDL 1120
L S A L A SLE+ R +DA +DR L
Sbjct: 932 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR------------L 979
Query: 1121 RAQREEAAAAHA-QEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE 1179
A+RE + +H Q++ + EQ + C+ E +++R QL E R R L
Sbjct: 980 MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE-TRTVHRLRLPL 1038
Query: 1180 AQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLA 1239
+ RE + R ++Q+A LG+G A L A + R L+L
Sbjct: 1039 DKEPARECAQ-RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT 1097
Query: 1240 NEDKEQKLAL----LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSE 1295
EQ +L LE+ +T G G +EV R+ E +E Q + + L++
Sbjct: 1098 LGKLEQVRSLSAIYLEKLKTISLVIRGT--QGAEEVLRAHEEQLKEAQAVPATLPELEAT 1155
Query: 1296 NTRLGRELAELQGRLALGERAEKESR-RETLGLRQRLLKGEASLEVMRQELQVAQRKLQE 1354
L + A+ + + + E R + +G R + GE +EV R +VAQ +
Sbjct: 1156 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1215
Query: 1355 QEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQG 1414
Q +T + R E +QL +L R A LG L A R +
Sbjct: 1216 QAVLAQT----------DVRQRELEQLGR------QLRYYRESADPLGAWLQDARRRQEQ 1259
Query: 1415 LEA-ELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEG 1473
++A LA + R + L R G + A + + +A + +
Sbjct: 1260 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI------NAIKDYELQL 1313
Query: 1474 LNSPSTLE--CSPGSQPPSPGPATSPASPDLDPEAVRGALR-------EFLQELRSAQRE 1524
+ + LE SP +P + S +D L +F+ E E
Sbjct: 1314 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1373
Query: 1525 RDELRTQTSALNRQ-LAEMEAERDSATSRARQLQKAVAESE-EARRSVDGRLSGVQAELA 1582
+ L Q A R+ LAE+EA A + RQL +A A+++ +A R +Q E+
Sbjct: 1374 EERLAEQQRAEERERLAEVEA----ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429
Query: 1583 LQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKE 1642
+EE+ +++++R+ +++ L Q++E+E++A + + + ++E + R ++
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLR---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1486
Query: 1643 VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGT 1702
L+A+E QR EGELQ R + EAQ + Q+ + L+RQV D +
Sbjct: 1487 QLEATER-------QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK-- 1537
Query: 1703 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKA-----LT 1757
++E L +V+ EA + +L + + L ++A
Sbjct: 1538 ---------------RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1582
Query: 1758 ACEHDRQVLQERLDAARQALSEARKQSSSLGEQV----QTLRGEVADLELQRVEAEGQLQ 1813
E RQV A R A +E + + +S E+ ++L+ E + R EAE + Q
Sbjct: 1583 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1642
Query: 1814 QLREVLRQRQEGEAAALNTVQKLQDERRL-LQERLGSLQRALAQLEAEKREVERSALRLE 1872
Q E R R+E E K + RL LQ + Q++LAQ EAEK++ E
Sbjct: 1643 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA------ 1696
Query: 1873 KDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV- 1931
+R A RR K E + +R E AE EL E QRQ+ + AQ
Sbjct: 1697 -EREARRR--GKAEEQAVRQREL-----------------AEQEL-EKQRQLAEGTAQQR 1735
Query: 1932 VVLEQSHSPAQLEVDAQQQQLE-LQQEVERL-RSAQAQTERTLEARERAHRQRVRGLEEQ 1989
+ EQ + E + +QQ + L++E+ RL R A A T++ E A +VR E
Sbjct: 1736 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL--EAELAKVRAEMEV 1793
Query: 1990 VSTLKGQLQQELRRSS 2005
+ K + ++E R +S
Sbjct: 1794 LLASKARAEEESRSTS 1809
Score = 48.9 bits (115), Expect = 5e-05
Identities = 48/216 (22%), Positives = 98/216 (45%), Gaps = 17/216 (7%)
Query: 5 LARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPES 64
LA ++V L IQ +S + +L ++ + A + ++ + + +
Sbjct: 2449 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2508
Query: 65 PVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRL 124
LL T+ L E++ LLQ+ E + Q +A+ ++L A +++L + +
Sbjct: 2509 EQLLQETQALQQSFLSEKDSLLQR-----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2563
Query: 125 EPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYK 184
+ ++E QE + LV E RR+ E + RRK + Q+ +Q++ Q + L
Sbjct: 2564 QQQQME-QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL-------- 2614
Query: 185 KRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI 220
+E Q+L E+ LE+Q HS+++ ++ +
Sbjct: 2615 ---AEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2647
Score = 35.4 bits (80), Expect = 0.57
Identities = 89/418 (21%), Positives = 174/418 (41%), Gaps = 43/418 (10%)
Query: 1606 ERSLQATESELRASQEKISKMKANETKL-EGDKRRLKEVLDASESRTVKLELQ------R 1658
ER ++ E+ + K K E E DK R K + + E +L+
Sbjct: 331 ERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP 390
Query: 1659 RSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVE 1718
+E E + + + +RE Q ++ +R++ LQR V +++AG L E+LN
Sbjct: 391 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG---LCEEQLN------- 440
Query: 1719 ESEGALRDKVRGLTEA-LAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQAL 1777
+++ L+ VR L + Q + + DK + + L +D Q L+ D
Sbjct: 441 QADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF---NDVQTLK---DGRHPQG 494
Query: 1778 SEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQ 1837
+ ++ L E++ +R E +L L+ A Q + L+ Q +T++ LQ
Sbjct: 495 EQMYRRVYRLHERLVAIRTEY-NLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ 553
Query: 1838 DERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV 1897
D ++E + A ++ E + + R L +++++ + R+ D
Sbjct: 554 DLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR------GLHQSIEEFRAKIERARSDEG 607
Query: 1898 RLS-AEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL-Q 1955
+LS A +G L +L+ A + + +A++ LE HS A ++ + L +
Sbjct: 608 QLSPATRGAYRDCLGRLDLQYA---KLLNSSKARLRSLESLHS---FVAAATKELMWLNE 661
Query: 1956 QEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQ---QELRRSSAPFSP 2010
+E E + + + A++ ++ +R LE + +K +LQ L R P P
Sbjct: 662 KEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK-ELQNAGDRLLREDHPARP 718
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 255 bits (651), Expect = 4e-67
Identities = 363/1535 (23%), Positives = 635/1535 (41%), Gaps = 197/1535 (12%)
Query: 590 EVQRLRSA----NELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEE 645
E+Q++ S+ N L S + LQ Q Q L+++ ++ ++EL + L E
Sbjct: 183 ELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELE---LAE 239
Query: 646 EQEDAVQDGARVRRELERSHRQ--LEQLEGKRSVLAKELVEVREALSRATL-------QR 696
++ + A++ +R R L + + + KEL E+R+ T+ Q
Sbjct: 240 NRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQC 299
Query: 697 DMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLN 756
L+ EK+++ + + +L + + + LQD+L++L+ + Q+ L+
Sbjct: 300 QDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQ 359
Query: 757 RLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE 816
AQLE+E SA ++ E++ + + + +LEE + + +G + E
Sbjct: 360 ---AQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLE 416
Query: 817 ALEQQLPTLRHERSQLQEQLAQLSRQLSGRE--------------QELEQARREAQRQVE 862
L+Q+ TL +QLQ ++ L + +E Q+L + Q +
Sbjct: 417 TLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSIS 476
Query: 863 ALERAAREKEALAKEH-AGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLA 921
L +A E E ++ H A L Q+ + E TL+ + E L+ E Q QLA
Sbjct: 477 NLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLA 536
Query: 922 QLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQ 981
Q ++EQ Q L E L+ L QQ+ EK ++ AQ+L A E +
Sbjct: 537 QTLQQQEQAS---QGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEERE 593
Query: 982 ASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEE 1041
ASLRE+ AA ++ L+ L++EK AA E+ ++ Q+ ++ + + + + + EK ELS +
Sbjct: 594 ASLRERDAALKQ-LEALEKEK-AAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRK 651
Query: 1042 IAALQ-------QERDEGL-------LLAESEKQQALSLKE--SEKTALSEKLMGTRHSL 1085
+ LQ QE+ E L SE+Q+A + EK L E+L + SL
Sbjct: 652 VEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESL 711
Query: 1086 ATISLEMERQKRDAQSRQEQDRSTVNALTSELRDL-------RAQREEAAAAHAQEVRRL 1138
+E +KR A E+ + ++ L +E R L R + EE A RL
Sbjct: 712 KVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARL 771
Query: 1139 QEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQ---- 1194
Q+ + + RE E E + L +E+ + + +SQ+ E Q
Sbjct: 772 QQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ-EEAQYGAM 830
Query: 1195 --------RQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLAN------ 1240
++E + R+ L E AKE+ A S+ EL+ + ++ E + LA
Sbjct: 831 FQEQLMTLKEECEKARQELQE-AKEKVAGIESHSELQISRQQNELAELHANLARALQQVQ 889
Query: 1241 --EDKEQKLA----LLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELR-----RQM 1289
E + QKLA L+E A KE L T +++ + A REL + RQ
Sbjct: 890 EKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQP 949
Query: 1290 KMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQ 1349
+ L+ + GR+ Q L ER ++ E LR L++ + + R + +
Sbjct: 950 EWLEEQQ---GRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREV 1006
Query: 1350 RKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAE 1409
+L ++ G R + L + AR + +L +A L R E A L L+ A
Sbjct: 1007 ARLTQERG----RAQADLALEKAARAELEMRLQNA------LNEQRVEFATLQEALAHAL 1056
Query: 1410 GRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEG 1469
+G + ELA++ A +L LR +++ + A+
Sbjct: 1057 TEKEGKDQELAKLRGLEAAQIKELEELRQTVKQ--------------LKEQLAKKEKEHA 1102
Query: 1470 SGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELR 1529
SG G S + T P P L EA+R + + Q+ + Q + D L
Sbjct: 1103 SGSGAQSEAA-------------GRTEPTGPKL--EALRAEVSKLEQQCQKQQEQADSLE 1147
Query: 1530 TQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVR 1589
A AERDSA LQ + E + L+ Q ELA V+
Sbjct: 1148 RSLEAERAS----RAERDSALET---LQGQLEEKAQELGHSQSALASAQRELAAFRTKVQ 1200
Query: 1590 RSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASES 1649
+ QVA + + S + + +E++S + + EG+ + LK ++ A
Sbjct: 1201 DHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESE 1260
Query: 1650 RTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVER 1709
++ KLE + R L+ E + ++R + AL++ V SL+ + V + E
Sbjct: 1261 KSQKLEERLRLLQAETASNSARAAER---SSALREEVQSLREEAEKQRVAS-------EN 1310
Query: 1710 LNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQ---KALTACEHDRQVL 1766
L L E L +++ E Q +L++ + ++ Q L +H Q L
Sbjct: 1311 LRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQL 1370
Query: 1767 QERLDAARQALSEARKQSSSL--GEQVQTLR-----GEVADLELQRVEAEGQLQQLREVL 1819
Q AA + E +QS G + + LR GE+ L + E E QQLR
Sbjct: 1371 QAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEK 1430
Query: 1820 RQRQEGEAAALNTVQKLQDERRLLQERLG------------SLQRALAQLEAEKREVERS 1867
E + L +E R L ER + ++ + +L A + + E
Sbjct: 1431 ASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETR 1490
Query: 1868 ALRLEKDRVALRRTLD----KVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQ 1923
++++ + R L+ K E K++ E+ R E+ +L + E+ E +Q
Sbjct: 1491 LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQ 1550
Query: 1924 IQQLEAQVVVLEQSHSPAQLEVDA-QQQQLELQQEVERLRS----AQAQTERTLEARER- 1977
+++L ++ +Q+ Q ++ A Q Q E QQE +RL++ QAQ + +A E
Sbjct: 1551 VEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHY 1610
Query: 1978 ------------AHRQRVRGLEEQVSTLKGQLQQE 2000
A +Q+ + L+EQ+ +L+ QLQ+E
Sbjct: 1611 KLQMEKAKTHYDAKKQQNQELQEQLRSLE-QLQKE 1644
Score = 242 bits (617), Expect = 3e-63
Identities = 399/1591 (25%), Positives = 663/1591 (41%), Gaps = 259/1591 (16%)
Query: 552 LRKQLSDSESERRALE-----------------------------------------EQL 570
L+KQL+D S R LE ++L
Sbjct: 219 LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKEL 278
Query: 571 QRLRDKTDG-AMQAHE-------------DAQREVQRLRSANELLSREKSNLAHSLQVAQ 616
+ LRDK + M+ HE R++ +L N LS + A LQ Q
Sbjct: 279 EELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQ 338
Query: 617 QQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRS 676
EL +E K A QE L +Q +LE+E A+QD + + E +L QLE S
Sbjct: 339 DALNELTEEHSK--ATQEWLEKQA-QLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLS 395
Query: 677 VLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEA---------GRVELELSMTKL 727
L + + + LQ + L+ E A +A T+ +A G+ E +L +
Sbjct: 396 QLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERG 455
Query: 728 RAEE---------ASLQDSLSKLSALNESLAQDK----LDLNRLVAQLEEEKSALQGRQR 774
EE LQ S+S LS E L Q L VA L E + L +
Sbjct: 456 HFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQ 515
Query: 775 QAEQEAT----VAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERS 830
Q +QE A+E+Q +L + +QE A QGL + + + EQQL + ++
Sbjct: 516 QQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQE 575
Query: 831 QLQEQLAQLSRQLSGREQELEQARRE---AQRQVEALERAAREKEALAKEHAGLA----- 882
++ AQ QL+ +E E + RE A +Q+EALE+ K + ++ +A
Sbjct: 576 ATRQDHAQ---QLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARD 632
Query: 883 ---VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLE--ARREQLEA-EGQA 936
+ A+RE LS + L+ E E Q Q+A+LE R EQ +A E +
Sbjct: 633 SAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKER 692
Query: 937 LLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAER---EAQASLREQRAAHEE 993
+ K+ L +L L++ + T+ +K A L + +R E +A R H+
Sbjct: 693 VAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKR 752
Query: 994 DLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARL----------EAEKEELSEEIA 1043
+ + L+ E+ A + LEA QL Q E E L L E+E E+L +E+A
Sbjct: 753 ERKELEEER-AGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA 811
Query: 1044 ALQQERDEGLLLAESE-----KQQALSLKESEKTALSEKLMGTRHSLATI----SLEMER 1094
A +ER E E++ ++Q ++LKE + A E L + +A I L++ R
Sbjct: 812 A-WRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQE-LQEAKEKVAGIESHSELQISR 869
Query: 1095 QKRD--------AQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLG 1146
Q+ + A++ Q+ V A +L D + +E AA ++EV RL+ R G
Sbjct: 870 QQNELAELHANLARALQQVQEKEVRA--QKLADDLSTLQEKMAATSKEVARLETLVRKAG 927
Query: 1147 KQRDSCLRE--AEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRS 1204
+Q+++ RE E R R E + R+ Q L+ + E E LR +
Sbjct: 928 EQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAA 987
Query: 1205 LGE---------GAKEREALRRSNEELRS----AVKKAESERISLKLANEDKEQKL--AL 1249
L E G +ERE R + E R+ A++KA + ++L N EQ++ A
Sbjct: 988 LMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFAT 1047
Query: 1250 LEEART-AVGKEAGELRTGLQEVERSR-LEAR--RELQELRRQMKMLDSENTRLGRELAE 1305
L+EA A+ ++ G+ QE+ + R LEA +EL+ELR+ +K L + + +E A
Sbjct: 1048 LQEALAHALTEKEGK----DQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHAS 1103
Query: 1306 LQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERR 1365
G ++E R E G + L+ E S KL++Q
Sbjct: 1104 -----GSGAQSEAAGRTEPTGPKLEALRAEVS-------------KLEQQ---------- 1135
Query: 1366 LLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQ 1425
+KQQ + A LE LEA RA AE L +G+ + EL +
Sbjct: 1136 ----------CQKQQ-EQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSA 1184
Query: 1426 RRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPG 1485
+A+ +L R+ + + S A AR L S E S
Sbjct: 1185 LASAQRELAAFRTKV-------QDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSIL 1237
Query: 1486 SQPPSPGPATSPASPDLDPEAVRGALREF-LQELRSAQRERDELR---TQTSALNRQLAE 1541
++ L+ E L+ + E +Q+ + LR +T++ + + AE
Sbjct: 1238 NRQV------------LEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAE 1285
Query: 1542 -MEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLD 1600
A R+ S + +K SE R+ + + + EL + ++ + ++ L
Sbjct: 1286 RSSALREEVQSLREEAEKQRVASENLRQELTSQAERAE-ELGQELKAWQEKFFQKEQALS 1344
Query: 1601 QVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRT--VKLELQR 1658
+ S QA SEL ++ +++A + E +R +E L+ S+ ++ EL R
Sbjct: 1345 TLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE---KRHREELEQSKQAAGGLRAELLR 1401
Query: 1659 RSLE-GELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKV 1717
E GEL R ++++E AQ L+ S Q++ + G L E G +
Sbjct: 1402 AQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHG---LLAEENRGLGERA 1458
Query: 1718 EESEGALRDKVRGLTEALAQSSASLNSTRDKNL-HLQKALTACEHDRQVLQERLDAARQA 1776
L ++ E Q A++ + + L +Q+ + + +V+ + + A+
Sbjct: 1459 NLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVK 1518
Query: 1777 LSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLR---QRQEGEAAALNTV 1833
+ E R++ E+ Q L +V LE+ + E Q+++L + L Q + + L V
Sbjct: 1519 VLEERQR---FQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAV 1575
Query: 1834 Q----KLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRV--ALRRTLDKVER 1887
Q + Q E + LQ +L LQ AQL +++ E L++EK + ++ ++ +
Sbjct: 1576 QAQGGESQQEAQRLQAQLNELQ---AQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQ 1632
Query: 1888 EKLRSHE----DTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQL 1943
E+LRS E + L AE RL L A L+ EA++ + L AQV LE + A
Sbjct: 1633 EQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHA-- 1690
Query: 1944 EVDAQQQQL-ELQQEVERLRSAQAQTERTLE 1973
D Q + L + Q + L+S + Q + L+
Sbjct: 1691 --DQQLRDLGKFQVATDALKSREPQAKPQLD 1719
Score = 237 bits (605), Expect = 8e-62
Identities = 432/1903 (22%), Positives = 787/1903 (41%), Gaps = 271/1903 (14%)
Query: 40 QDAQITSLPALIREIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQ 99
+DAQI + I + N Q SP+ E L L+++N+ L L
Sbjct: 247 KDAQIAMMQQRIDRLALLNEKQAASPL-----EPKELEELRDKNESLTMRLHETLKQCQD 301
Query: 100 SRAERDELAIKYNAVSER---LEQALRLEPGELETQEP--RGLVRQSVELRRQLQEEQAS 154
+ E+ ++ K N +SE L LR L+ + L + + ++ E+QA
Sbjct: 302 LKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQ 361
Query: 155 YRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGE----------LEQQ 204
++L A + ++ + + LQGK+ Q ++ S+L+ + GE L+Q+
Sbjct: 362 LEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE 421
Query: 205 RLRDTEHSQDLESALIRLEEEQ-QRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTND 263
++ L++ + LE E+ Q+ A L E+ Q S L D++ ++
Sbjct: 422 AATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSS----LITDLQSSISN 477
Query: 264 WTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQ----VVGFRRLVSEVKMFTER 319
++ ++ELE A + A ++E + L +Q + G ++ E +
Sbjct: 478 LSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKE----KQA 533
Query: 320 DLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQL------RD 373
L Q + + S+ ++ LS+ L+ E + + EKQ + +QL R+
Sbjct: 534 QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEERE 593
Query: 374 KVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTE--KLEALE 431
LRE+D A +Q+++ L+K + +L + ++L+ N +D +T+ + +A
Sbjct: 594 ASLRERDAALKQLEA-LEKE----KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAEL 648
Query: 432 SLRLQE-QAALET--EDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLS 488
S +++E QA +ET ++ Q + +L + S+ + + + D L+ L
Sbjct: 649 SRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALK 708
Query: 489 GQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDL 548
+ + G +R + AL ++Q + +++ + +
Sbjct: 709 ESL------KVTKGSLEEEKRRAA-------------DALEEQQRCISELKAETRSLVEQ 749
Query: 549 LGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNL 608
RK+L + + R+ LE +LQ+L + AH+ + E+L RE +
Sbjct: 750 HKRERKELEEERAGRKGLEARLQQLGE-------AHQ----------AETEVLRRELAEA 792
Query: 609 AHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQL 668
+ A+ + E+L +E+ R+R E+ Q++ Q GA + +L
Sbjct: 793 MAAQHTAESECEQL----------VKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLK--- 839
Query: 669 EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLR 728
E+ E R L + +V S + LQ Q E AE+ L +A + +++
Sbjct: 840 EECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARA----------LQQVQ 889
Query: 729 AEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQ- 787
+E Q LS L E +A ++ RL + + + R+ +E A + Q
Sbjct: 890 EKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQP 949
Query: 788 ERLEELRLEQEVARQG-LEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGR 846
E LEE + Q + Q L+ R AEQ LE+ L + Q QE+ Q R+++
Sbjct: 950 EWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVA-- 1007
Query: 847 EQELEQARREAQRQVEALERAAREKEALAKEHA-------------GLAVQLVAAEREGR 893
L Q R AQ + ALE+AAR + + ++A LA L E + +
Sbjct: 1008 --RLTQERGRAQADL-ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQ 1064
Query: 894 TLSE----EATRLRLEKEALEGSLFEVQRQLAQLEARRE-----QLEAEGQALLLAK--E 942
L++ EA +++ E E L ++ +++ QLA+ E Q EA G+ E
Sbjct: 1065 ELAKLRGLEAAQIK-ELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLE 1123
Query: 943 TLTGELAGLRQQIIATQEKA-SLDKELMAQKLVQAERE-AQASLREQRAAHEEDLQRLQR 1000
L E++ L QQ QE+A SL++ L A++ +AER+ A +L+ Q ++L Q
Sbjct: 1124 ALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQS 1183
Query: 1001 EKEAAWRELEAERAQLQSQLQREQE----ELLARLEAEKEE-----LSEEIAALQQE--R 1049
+A REL A R ++Q + E E R EAE++ L EE++ L ++
Sbjct: 1184 ALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLE 1243
Query: 1050 DEG-------LLLAESEKQQALSLK--------ESEKTALSEKLMGTRHSLATISLEMER 1094
EG L++AESEK Q L + S +E+ R + ++ E E+
Sbjct: 1244 KEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEK 1303
Query: 1095 QKRDAQSRQEQDRSTVNALTSELRDLRA------QREEAAAAHAQEVRRLQEQARDLGKQ 1148
Q+ +++ +++ S ++L+A Q+E+A + E Q +L
Sbjct: 1304 QRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPA 1363
Query: 1149 RDSCLR-EAEEL------RTQLRLLEDARDGLRRELLEAQRKLRESQEGREV---QRQEA 1198
+ C + +AE+ R +L + A GLR ELL AQR+L E R+ Q + A
Sbjct: 1364 KHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTA 1423
Query: 1199 GELRRSLGEGAKEREALRRSN----EELRSAVKKAESER----ISLKLANEDKEQKLALL 1250
+LR A++ L++++ EE R ++A R + L A E Q+LA +
Sbjct: 1424 QQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAV 1483
Query: 1251 E-EARTAVGKEAGELRTGLQEVE--------------RSRLEARRELQELRRQMKMLDSE 1295
+A T + + E ++ +E+E R + E Q+L Q++ L+
Sbjct: 1484 RADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVF 1543
Query: 1296 NTRLGRELAELQGRLALGERAEK--------------ESRRETLGLRQRLLKGEASLEVM 1341
+++ EL +LA ++A K ES++E L+ +L + +A L
Sbjct: 1544 QREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQK 1603
Query: 1342 RQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARA--EAA 1399
Q + + ++++ + + ++++ E+ R E+ Q ++ EL+ EA R E
Sbjct: 1604 EQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENK---ELRAEAERLGHELQ 1660
Query: 1400 ELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGL-RSALRRGLGLGRAPSPAPRPVP 1458
+ GL+ AE + L A++ +E Q A+ QL L + + R P P+
Sbjct: 1661 QAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDL 1720
Query: 1459 GSPARDAPAEGSGEGLNSPSTLECSPGSQPPS---PGPATSPASPDLDPEAVRGALREFL 1515
+ D E G L+ S L P +QP PG SP S L P+ E L
Sbjct: 1721 SIDSLDLSCE-EGTPLSITSKL---PRTQPDGTSVPGEPASPISQRLPPKVES---LESL 1773
Query: 1516 QELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQL-------QKAVAESEEARR 1568
R + L + +L + + SA R Q+ + V E + A
Sbjct: 1774 YFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRRTTQIINITMTKKLDVEEPDSANS 1833
Query: 1569 SVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQA----TESELRASQEKIS 1624
S S ++ +L+ S +S R + D + SL T S R SQ +S
Sbjct: 1834 SFYSTRSAPASQASLRATSSTQS-LARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVS 1892
Query: 1625 K--MKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQAL 1682
+ G + E LD +R +L+ + R L+ L
Sbjct: 1893 SGAPPGRNSFYMGTCQDEPEQLD-DWNRIAELQQRNRVCPPHLKT-----------CYPL 1940
Query: 1683 QDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASL 1742
+ R + D E+K G Q T+ R ++ ++ +EG G+T + SL
Sbjct: 1941 ESRPSLSLGTITDEEMKTGDPQETLRR--ASMQPIQIAEGT------GITTRQQRKRVSL 1992
Query: 1743 NSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSS 1785
+ K T+C ++R + +Q+ +EA+K+++
Sbjct: 1993 EPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQKKAA 2035
Score = 232 bits (591), Expect = 3e-60
Identities = 360/1593 (22%), Positives = 677/1593 (42%), Gaps = 196/1593 (12%)
Query: 309 LVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLE 368
L K+ TE+D ++A + + L L E +A + LE + L
Sbjct: 237 LAENRKLLTEKD-----AQIAMMQQRIDRLAL-------LNEKQAASPLEPKEL------ 278
Query: 369 EQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLE 428
E+LRDK + L + ++ DL +++ + +L ++N + ++ L+
Sbjct: 279 EELRDK---NESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335
Query: 429 ALESL--RLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRG 486
L+ L E+ + T++ Q L A L D + L L
Sbjct: 336 QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKC---LEEKNEILQGKLSQLEE 392
Query: 487 LSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQ 546
Q +PP+ G + +++TLA ++ L R ++ RG+ EA
Sbjct: 393 HLSQLQDNPPQEKGEVLGDVLQL--ETLKQEAATLAANNTQLQARVEMLETERGQQEAK- 449
Query: 547 DLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQ----RLRSANELLS 602
L + E E++ L + L+ QA E+ ++ Q RL + L+
Sbjct: 450 -----LLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLT 504
Query: 603 REKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELE 662
E + L ++Q Q+ L+Q+ ++ QA + +Q+++ + V+ + ++ E
Sbjct: 505 SELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKE 564
Query: 663 RSHRQL-EQLEGKRSVLAKELV---EVREALSR----ATLQRDMLQAEKAEVAEALTK-- 712
+ +++ E+ E R A++L E REA R A Q + L+ EKA E L +
Sbjct: 565 QQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQL 624
Query: 713 --AEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQ 770
A R + S+T+ + E+A L + +L A E+ Q++ + VA+LE + L+
Sbjct: 625 QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ---LR 681
Query: 771 GRQRQAEQEATVAREE---QERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRH 827
Q++A ++ VA+E+ QE+L+ L+ +V + LE R A A E ++ + L+
Sbjct: 682 SEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKA 741
Query: 828 ERSQLQEQLAQLSRQL-------SGREQELEQARREAQRQVEALERAAREKEALAKEHAG 880
E L EQ + ++L G E L+Q Q + E L R EA+A +H
Sbjct: 742 ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRREL--AEAMAAQHTA 799
Query: 881 LA-----VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQ 935
+ V+ VAA RE S+ ++EA G++F+ QL +E+ E Q
Sbjct: 800 ESECEQLVKEVAAWRERYEDSQ-------QEEAQYGAMFQ-----EQLMTLKEECEKARQ 847
Query: 936 ALLLAKETLTG-----ELAGLRQQIIATQEKASLDKEL--MAQKLVQAEREAQ--ASLRE 986
L AKE + G EL RQQ + A+L + L + +K V+A++ A ++L+E
Sbjct: 848 ELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQE 907
Query: 987 QRAAHEEDLQRLQ-------REKEAAWRELEAERAQ--------LQSQLQRE---QEELL 1028
+ AA +++ RL+ ++E A REL E A+ L+ Q R+ + L
Sbjct: 908 KMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAAL 967
Query: 1029 ARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATI 1088
+E E E++ E+ L+ L+ ++ ++Q+ +E E L+++ A
Sbjct: 968 QAMEREAEQMGNELERLR----AALMESQGQQQEERGQQEREVARLTQE-----RGRAQA 1018
Query: 1089 SLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQ 1148
L +E+ +R E + NAL + + +E A A ++ + QE A+ G +
Sbjct: 1019 DLALEK-----AARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLE 1073
Query: 1149 RDSCLREAEELRTQLRLLEDARDGLRRE-------LLEAQRKLRESQEGREVQRQEAGEL 1201
+ ++E EELR ++ L++ +E EA + + E R E +L
Sbjct: 1074 A-AQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKL 1132
Query: 1202 RRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEA 1261
+ + ++ ++L RS E R++ + +S +L+ E+K Q+L + A + +E
Sbjct: 1133 EQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQREL 1192
Query: 1262 GELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESR 1321
RT +Q+ ++ E + ++ R++ + +S + L E++ L ++ E KE +
Sbjct: 1193 AAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELK 1252
Query: 1322 RETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQL 1381
R + ++ K E L +++ E + E+ R + L EEA EKQ++
Sbjct: 1253 RLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSL---REEA---EKQRV 1306
Query: 1382 DHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALR 1441
+ L +L + A ELG L A + + E L+ ++++ + +A + L
Sbjct: 1307 -ASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSEL----- 1360
Query: 1442 RGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPD 1501
PA A A AE LE S
Sbjct: 1361 ---------LPAKHLCQQLQAEQAAAE-----KRHREELEQS------------------ 1388
Query: 1502 LDPEAVRGALREFLQELRSAQRERDE---LRTQTSALNRQLAEMEAERDSATSRARQLQK 1558
+ G LR EL AQRE E LR + + R ++ AE+ S + L+K
Sbjct: 1389 ---KQAAGGLR---AELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKK 1442
Query: 1559 AVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATL-----DQVATLERSLQATE 1613
A E R + R + + L ++ + R + A + ++A ++R Q+T
Sbjct: 1443 AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTA 1502
Query: 1614 SELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLS 1673
EL + +K + + K+ +++R +E ++ +LE+ +R +++ L+
Sbjct: 1503 REL---EVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLA 1559
Query: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR---DKVRG 1730
D + ++ Q ++ ++Q Q +S+ +A LQ + L L++ E++ + +K +
Sbjct: 1560 DSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKT 1619
Query: 1731 LTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQ 1790
+A Q + L LQK + + L L A EA + L Q
Sbjct: 1620 HYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQ 1679
Query: 1791 VQTLRGEVADLELQRVEAEGQLQQLREVLRQRQ 1823
V++L +VA + Q++ G+ Q + L+ R+
Sbjct: 1680 VRSLEAQVAHAD-QQLRDLGKFQVATDALKSRE 1711
Score = 217 bits (553), Expect = 8e-56
Identities = 384/1551 (24%), Positives = 646/1551 (41%), Gaps = 222/1551 (14%)
Query: 521 LALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDG- 579
LA L ++ Q+ M+ R D L L ++ + S E + LEE LRDK +
Sbjct: 237 LAENRKLLTEKDAQIAMMQQRI----DRLALLNEKQAASPLEPKELEE----LRDKNESL 288
Query: 580 AMQAHEDAQ-------------REVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQER 626
M+ HE + R++ +L N LS + A LQ Q EL +E
Sbjct: 289 TMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEH 348
Query: 627 EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVR 686
K A QE L +Q +LE+E A+QD + + E +L QLE S L + +
Sbjct: 349 SK--ATQEWLEKQA-QLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEK 405
Query: 687 EALSRATLQRDMLQAEKAEVAEALTKAEA---------GRVELELSMTKLRAEE------ 731
+ LQ + L+ E A +A T+ +A G+ E +L + EE
Sbjct: 406 GEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLS 465
Query: 732 ---ASLQDSLSKLSALNESLAQDK----LDLNRLVAQLEEEKSALQGRQRQAEQEAT--- 781
LQ S+S LS E L Q L VA L E + L +Q +QE
Sbjct: 466 SLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLK 525
Query: 782 -VAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLS 840
A+E+Q +L + +QE A QGL + + + EQQL + ++ ++ AQ
Sbjct: 526 QQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQ-- 583
Query: 841 RQLSGREQELEQARRE---AQRQVEALERAAREKEALAKEHAGLA--------VQLVAAE 889
QL+ +E E + RE A +Q+EALE+ K + ++ +A + A+
Sbjct: 584 -QLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQ 642
Query: 890 REGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEA--RREQLEA-EGQALLLAKETLTG 946
RE LS + L+ E E Q Q+A+LE R EQ +A E + + K+ L
Sbjct: 643 REKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQE 702
Query: 947 ELAGLRQQIIATQEKASLDKELMAQKLVQAER---EAQASLREQRAAHEEDLQRLQREKE 1003
+L L++ + T+ +K A L + +R E +A R H+ + + L+ E+
Sbjct: 703 QLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEER- 761
Query: 1004 AAWRELEAERAQLQSQLQREQEELLARL----------EAEKEELSEEIAALQQERDEGL 1053
A + LEA QL Q E E L L E+E E+L +E+AA + ER E
Sbjct: 762 AGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWR-ERYEDS 820
Query: 1054 LLAESE-----KQQALSLKESEKTALSEKLMGTRHSLATISLEMERQ-KRDAQSRQEQDR 1107
E++ ++Q ++LKE + A E L + +A I E Q R E
Sbjct: 821 QQEEAQYGAMFQEQLMTLKEECEKARQE-LQEAKEKVAGIESHSELQISRQQNELAELHA 879
Query: 1108 STVNALTS-ELRDLRAQR--------EEAAAAHAQEVRRLQEQARDLGKQRDSCLREA-- 1156
+ AL + +++RAQ+ +E AA ++EV RL+ R G+Q+++ RE
Sbjct: 880 NLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVK 939
Query: 1157 EELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGE--------- 1207
E R R E + R+ Q L+ + E E LR +L E
Sbjct: 940 EPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEER 999
Query: 1208 GAKEREALRRSNEELRS----AVKKAESERISLKLANEDKEQKL--ALLEEART-AVGKE 1260
G +ERE R + E R+ A++KA + ++L N EQ++ A L+EA A+ ++
Sbjct: 1000 GQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEK 1059
Query: 1261 AGELRTGLQEVERSR-LEAR--RELQELRRQMKMLDSENTRLGRELAELQGRLALGERAE 1317
G+ QE+ + R LEA +EL+ELR+ +K +L +LA+ + A G A+
Sbjct: 1060 EGKD----QELAKLRGLEAAQIKELEELRQTVK-------QLKEQLAKKEKEHASGSGAQ 1108
Query: 1318 KES--RRETLGLRQRLLKGEAS-LEVMRQELQVAQRKLQEQ-EGEFRTRERR------LL 1367
E+ R E G + L+ E S LE Q+ Q L+ E E +R R L
Sbjct: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQ 1168
Query: 1368 GSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRR 1427
G LEE + Q+L H++ L +A+ E A ++ +A++AR +
Sbjct: 1169 GQLEE----KAQELGHSQSA---LASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAE 1221
Query: 1428 AAEAQLGGLR---SALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSP 1484
+ + L S L R + S + + + + + L T S
Sbjct: 1222 RKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSA 1281
Query: 1485 GSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDEL---------------- 1528
+ S S + E R A QEL S +EL
Sbjct: 1282 RAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQ 1341
Query: 1529 --------RTQTSALNRQLA-------EMEAERDSATSRAR----QLQKAV----AESEE 1565
T T AL +L +++AE+ +A R R Q ++A AE
Sbjct: 1342 ALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLR 1401
Query: 1566 ARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISK 1625
A+R + G L ++ ++A QE + ++ E+ + +Q++ L+++ E R E+ +
Sbjct: 1402 AQREL-GELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGER-AN 1459
Query: 1626 MKANETKLEGDKRRLKEVLDAS------ESRTVKLELQRRSLEGELQRSRLGLSDREAQA 1679
+ ++E D+ R K V + + E+R +++ + +S EL+ + +
Sbjct: 1460 LGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKV 1519
Query: 1680 ----QALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEAL 1735
Q Q+ L QV EV VE L+ LA +++ + K++ +
Sbjct: 1520 LEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQG 1579
Query: 1736 AQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLR 1795
+S + + LQ L+ E + + +++ A+ ++Q+ L EQ+++L
Sbjct: 1580 GESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE 1639
Query: 1796 GEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALA 1855
L+ + E + ++L L+Q A L T + Q R L + +
Sbjct: 1640 ----QLQKENKELRAEAERLGHELQQ------AGLKTKEAEQTCRHLTAQ--------VR 1681
Query: 1856 QLEAEKREVERSALRLEKDRVA--LRRTLDKVEREKLRSHEDTVRLSAEKG 1904
LEA+ ++ L K +VA ++ + + +L D++ LS E+G
Sbjct: 1682 SLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEG 1732
Score = 173 bits (438), Expect = 2e-42
Identities = 291/1270 (22%), Positives = 532/1270 (41%), Gaps = 191/1270 (15%)
Query: 8 AQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPESPVL 67
A++ E T + Q L ++ +E L RD A + L AL +E
Sbjct: 571 AEKQEATRQDHAQQLATAAEEREASLRERDAA----LKQLEALEKE-------------- 612
Query: 68 LPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPG 127
+ A L LQ++ Q+ + + + Q++ E+ EL+ K + +E A
Sbjct: 613 ----KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETA------ 662
Query: 128 ELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRC 187
QE Q EL QL+ EQ K + QE Q Q QL Q L+ + K
Sbjct: 663 ---RQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQL-QALKESLKVTK--- 715
Query: 188 SELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAG 247
LE++ + LE+Q+ +E + S + + + E++ L +L Q G
Sbjct: 716 GSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLG 775
Query: 248 SANQALSEDIRKVTNDWTRCR-------KELEHREAAWR-------REEESFNAYFSNEH 293
A+QA +E +R+ + + ++L AAWR +EE + A F +
Sbjct: 776 EAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQ- 834
Query: 294 SRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRA 353
L+ L + R+ + E K E G+ + L SR
Sbjct: 835 --LMTLKEECEKARQELQEAK----------------------EKVAGIESHSELQISRQ 870
Query: 354 EAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLE--- 410
+ L A L A L L+ ++EK++ Q++ DL + L ++ V RLE
Sbjct: 871 QNEL---AELHANLARALQQ--VQEKEVRAQKLADDL--STLQEKMAATSKEVARLETLV 923
Query: 411 -KQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQ 469
K +++ +++L + E R ++ E+ +G Q QA L E +
Sbjct: 924 RKAGEQQETASRELVK-----EPARAGDRQPEWLEEQQGRQFC---STQAALQAMEREAE 975
Query: 470 LSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALH 529
G+E + +L GQ+ ++ + RG + A LAL +A
Sbjct: 976 QMGNE--LERLRAALMESQGQQQEERGQQEREVARLTQERGRAQA-----DLALEKAARA 1028
Query: 530 KRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQR 589
+ ++++Q+ TL++ L+ + +E+ +++L +LR ++ E+ ++
Sbjct: 1029 ELEMRLQNALNEQRVE---FATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQ 1085
Query: 590 EVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQED 649
V++L+ E L++++ A + A KL+A + E+ + + +++QE
Sbjct: 1086 TVKQLK---EQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQ 1142
Query: 650 AVQDGARVRRELERSHR-----QLEQLEGKRSVLAKELVEVREALSRATLQ----RDMLQ 700
A D E ER+ R LE L+G+ A+EL + AL+ A + R +Q
Sbjct: 1143 A--DSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQ 1200
Query: 701 AEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVA 760
E + GR E E + + +SL++ +S L+ + +L RLV
Sbjct: 1201 DHSKAEDEWKAQVARGRQEAERKNSLI----SSLEEEVSILNRQVLEKEGESKELKRLVM 1256
Query: 761 QLEEEKSALQGRQR-----------QAEQEATVAREEQERLEELRLEQEVARQGLEGSLR 809
E+ L+ R R +A + ++ REE + L E +Q VA + L L
Sbjct: 1257 AESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELT 1316
Query: 810 VAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGRE---QELEQAR---REAQRQVEA 863
+ E L Q+L + + Q ++ L+ L + + + EL A+ ++ Q + A
Sbjct: 1317 SQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAA 1376
Query: 864 LERAAREKEALAKEHA-GLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ 922
E+ RE+ +K+ A GL +L+ A+RE G L +++++A+
Sbjct: 1377 AEKRHREELEQSKQAAGGLRAELLRAQRE------------------LGELIPLRQKVAE 1418
Query: 923 LEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQA 982
E +QL AE + L L ++ E+A+L ++ + +L QA +
Sbjct: 1419 QERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQ 1478
Query: 983 SLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEI 1042
L RA E L +QRE ++ RELE + A+ E K ++ EE
Sbjct: 1479 ELAAVRADAETRLAEVQREAQSTARELEV---------------MTAKYEGAKVKVLEER 1523
Query: 1043 AALQQERDEGLLLAESEKQQALSLKESEKT-ALSEKLMGTRHSLATISLEMER-QKRDAQ 1100
Q+ER + L A+ E+ + +++++ LS+KL + + +++ Q + +
Sbjct: 1524 QRFQEERQK--LTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGE 1581
Query: 1101 SRQEQDRSTVNALTSELRDLRAQ--REEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEE 1158
S+QE R L ++L +L+AQ ++E AA H + + D KQ++ +E
Sbjct: 1582 SQQEAQR-----LQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQN------QE 1630
Query: 1159 LRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREA-LRR 1217
L+ QLR LE + + EA+R E Q+ ++ +EA + R L + EA +
Sbjct: 1631 LQEQLRSLEQLQKENKELRAEAERLGHELQQA-GLKTKEAEQTCRHLTAQVRSLEAQVAH 1689
Query: 1218 SNEELRSAVK 1227
++++LR K
Sbjct: 1690 ADQQLRDLGK 1699
Score = 141 bits (355), Expect = 7e-33
Identities = 214/969 (22%), Positives = 385/969 (39%), Gaps = 134/969 (13%)
Query: 1134 EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREV 1193
++RRL++Q D RD E E R +L +DA+ + ++ ++ L E Q +
Sbjct: 215 QMRRLKKQLADERSNRDELELELAENR-KLLTEKDAQIAMMQQRIDRLALLNEKQAASPL 273
Query: 1194 QRQEAGELRRS-------LGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQK 1246
+ +E ELR L E K+ + L+ ++ + + E L +
Sbjct: 274 EPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASH 333
Query: 1247 LALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAEL 1306
L L++A + +E + QE + + +EL + K L+ +N L +L++L
Sbjct: 334 LQQLQDALNELTEEHSK---ATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQL 390
Query: 1307 QGRLALGERAEKESRRETLG--LRQRLLKGEAS------------LEVMRQELQVAQRKL 1352
+ L+ + + + E LG L+ LK EA+ +E++ E + KL
Sbjct: 391 EEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKL 450
Query: 1353 QEQEGEFRTRERRL----------LGSLEEARGTEKQQLDHARGLELKLEAARAEAAELG 1402
+ G F +++L + +L +A+ E +Q A G L A+ A L
Sbjct: 451 LAERGHFEEEKQQLSSLITDLQSSISNLSQAK-EELEQASQAHGARLT-----AQVASLT 504
Query: 1403 LRLSAAEGRAQGLEAELARVEVQRRAAEAQLGG-LRSALRRGLGLGRAPSPAPRPVPGSP 1461
L+ Q + ELA ++ Q + +AQL L+ + GL +
Sbjct: 505 SELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKE 564
Query: 1462 ARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPAS-PDLDP-EAVRGALREFLQE-L 1518
+ E + + ++ A+ L+ E + A E LQ+ L
Sbjct: 565 QQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQL 624
Query: 1519 RSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQ 1578
+ A RD +T + R+ AE+ + + +LQ V + + + +++ +
Sbjct: 625 QVANEARDSAQTSVTQAQREKAEL-------SRKVEELQACVETARQEQHEAQAQVA--E 675
Query: 1579 AELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKR 1638
EL L+ E + +E+ER A + L+ LQA + L K + LE +KR
Sbjct: 676 LELQLRSEQQKATEKERVA--QEKDQLQEQLQALKESL----------KVTKGSLEEEKR 723
Query: 1639 RLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSL-QRQVADSE 1697
R + L+ + +L+ + RSL + +R R L + A + L+ R+ L + A++E
Sbjct: 724 RAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETE 783
Query: 1698 VKAGTLQLTVERLNGALAKVEE---SEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQK 1754
V L + + A ++ E+ A R++ + AQ A L
Sbjct: 784 VLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQE------QLMT 837
Query: 1755 ALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQ 1814
CE RQ LQE + S + Q S ++ L +A Q E E + Q+
Sbjct: 838 LKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQK 897
Query: 1815 LREVLRQRQEGEAAALNTVQKLQD------------ERRLLQE--RLGSLQ--------- 1851
L + L QE AA V +L+ R L++E R G Q
Sbjct: 898 LADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQG 957
Query: 1852 ----RALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLD 1907
A L+A +RE E+ LE+ R AL + + + E+ + + RL+ E+GR
Sbjct: 958 RQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQ 1017
Query: 1908 RTL-----TGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQ------LELQQ 1956
L AELE+ Q + + + L+++ + A E + + Q+ LE Q
Sbjct: 1018 ADLALEKAARAELEM-RLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQ 1076
Query: 1957 --EVERLRSAQAQTERTLEARERAHRQ-----------------RVRGLEEQVSTLKGQL 1997
E+E LR Q + L +E+ H ++ L +VS L+ Q
Sbjct: 1077 IKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQC 1136
Query: 1998 QQELRRSSA 2006
Q++ ++ +
Sbjct: 1137 QKQQEQADS 1145
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 248 bits (633), Expect = 4e-65
Identities = 463/1941 (23%), Positives = 771/1941 (39%), Gaps = 303/1941 (15%)
Query: 184 KKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQL 243
+ RC E L +R E +Q+R + + E R ++ Q++ LA+ +Q
Sbjct: 100 RARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQE 159
Query: 244 DQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRL----LLL 299
Q E++ + +W +E E R R EEE + +E L
Sbjct: 160 RLEQRDRQRRDEELWRQRQEW----QEREER----RAEEEQLQSCKGHETEEFPDEEQLR 211
Query: 300 WRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQE----AGLGLSTGLRLAESR-AE 354
R+++ RR E K R+ R R QE T LR E + E
Sbjct: 212 RRELLELRRKGREEKQQQRRE---------RQDRVFQEEEEKEWRKRETVLRKEEEKLQE 262
Query: 355 AALEKQALLQAQLEEQL----RDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLE 410
++Q LQ + EEQL R ++ RE+ +QQ Q R+ ++ E
Sbjct: 263 EEPQRQRELQEE-EEQLRKLERQELRRERQEEEQQQQ----------RLRREQQLRRKQE 311
Query: 411 KQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQL 470
++ E+ + ++ E+ E E R Q+ L E E +Q LR + E Q
Sbjct: 312 EERREQQEERREQQERREQQEERREQQ---LRREQEERREQQLRR-----EQEEERREQQ 363
Query: 471 SGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHK 530
E+ + LR R RR R R L +
Sbjct: 364 LRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRR--------------EQQLRR 409
Query: 531 RQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQRE 590
Q ++ + R E Q L ++ + + E+ E++L+R +++ ++ E+ +R
Sbjct: 410 EQQLRREQQLRRE--QQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERH 467
Query: 591 VQRLRSANELLSREKSNLAHSLQVAQQQAEELRQERE-KLQAAQEELRRQRDRLEEEQE- 648
Q R +E+ L++ +++ E ++ RE +L+ QEE R QR + +EE+E
Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEER 527
Query: 649 --DAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEV 706
++ ++RRE E QL + E ++ L +E E R + + +L+ E+
Sbjct: 528 LQQRLRSEQQLRREQEERREQLLKREEEKR-LEQERREQRLKREQEERRDQLLKREEERR 586
Query: 707 AEALTKAEAGRVELELSMTKL-RAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEE 765
+ L + + R+E L ++ R E+ ++ K E Q L + Q E
Sbjct: 587 QQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL---KSEEQEERR 643
Query: 766 KSALQGRQRQAEQEATVAREEQERLEE-LRLEQEVARQGLEGSLRVAEQAQEALEQQLP- 823
+ L+ Q++ ++ EE+ERLE+ L+ E E R+ E + EQA+E ++ ++P
Sbjct: 644 QQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK 703
Query: 824 ---TLRHERSQLQEQLAQLSRQLSG----REQELEQARREAQRQVEALERAAREKEA--- 873
L E Q ++ R+ G +EQE ++ RRE++ Q + ERA R+++
Sbjct: 704 WQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQ 763
Query: 874 --------LAKEHAGLAVQLVAA------------------EREGRTLSEE-----ATRL 902
A+E + Q ++A +RE R L EE R
Sbjct: 764 RRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQ 823
Query: 903 RLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKA 962
R E+E E E + QL + E R +QL+ E L +E + +Q + +
Sbjct: 824 RREREK-ELQFLEEEEQLQRRE-RAQQLQEEEDGLQEDQERRRSQ-----EQRRDQKWRW 876
Query: 963 SLDKELMAQK-LVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQ 1021
L++E ++ + A+ Q LR+++ +E+ + LQRE+ R E ER + +
Sbjct: 877 QLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQL 936
Query: 1022 REQEELLARLEAEKEELSEEIAALQ-----QERDEGLLLAESEKQQALSLKESEKTALSE 1076
+++EE L R E EK E + Q+++E LL E EK++ +E EK E
Sbjct: 937 QQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRR---QEREKKYREE 993
Query: 1077 KLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVR 1136
+ L ++ R++R+ + RQE +R +D Q EE +E R
Sbjct: 994 E------ELQQEEEQLLREEREKRRRQEWERQ------YRKKDELQQEEEQLLREEREKR 1041
Query: 1137 RLQEQARDLGKQRDSCLREAEEL-RTQLRLLEDARDGLRRELLEAQRKLRE--SQEGREV 1193
RLQE+ R RE EEL + + +LL + R+ RR+ LE Q + E QE ++
Sbjct: 1042 RLQERERQ--------YREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL 1093
Query: 1194 QRQEAGELRRSLGE-GAKEREALRRSNEEL----RSAVKKAESERISLKLANEDKEQKLA 1248
R+E + RR E +E E L++ E+L R ++ E ER + +E++
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153
Query: 1249 LLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQG 1308
L EE +E +E+++ + RE QE RRQ E R RE ELQ
Sbjct: 1154 LREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ------ERERQYREEEELQ- 1206
Query: 1309 RLALGERAEKESRRETLGLR---------------------QRLLKGEASLEVMRQELQV 1347
R +R E +R L + ++ + E S RQ Q
Sbjct: 1207 RQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQD 1266
Query: 1348 AQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSA 1407
Q L EQ+ R +ERR + E++QL+ E K +++ + LR
Sbjct: 1267 LQHLLGEQQERDREQERR-RWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREER 1325
Query: 1408 AEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPA 1467
E R R E R+ E + L R P R R+
Sbjct: 1326 EEKR--------RRQETDRKFREEE----------QLLQEREEQPLRRQERDRKFREEEL 1367
Query: 1468 EGSGEG---LNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRE 1524
+G L L E R L+E Q+LR +RE
Sbjct: 1368 RHQEQGRKFLEEEQRLR---------------------RQERERKFLKE-EQQLRCQERE 1405
Query: 1525 RD-------ELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGV 1577
+ + R + L+RQ + + + R ++ ++ E E+ R R
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE 1465
Query: 1578 QAEL--ALQEESVRRSERERRATLD--QVATLERSLQATESELRASQEKISKMKANETKL 1633
+ +L +E+ + R ER+R+ + Q+ ER + E ELR SQE K E +L
Sbjct: 1466 EEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELR-SQEPERKFLEEEQQL 1524
Query: 1634 EGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV 1693
+R+ K + + + RR G+ +R RE + + L RQ
Sbjct: 1525 HRQQRQRKFLQEEQQ--------LRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE 1576
Query: 1694 ADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQ 1753
D + + L+ R K E E LR + + L RD+
Sbjct: 1577 RDRKFR---LEEQKVRRQEQERKFMEDEQQLRRQ---------EGQQQLRQERDRKF--- 1621
Query: 1754 KALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVAD----------LEL 1803
D Q+LQER Q L + L E+ Q R E E
Sbjct: 1622 ------REDEQLLQER---EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREE 1672
Query: 1804 QRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKRE 1863
+++ EG+ QQLR R R+ E +++ + ER+ LQE ++ L + E E++
Sbjct: 1673 EQLLQEGEEQQLRRQERDRKFREEE--QQLRRQERERKFLQE-----EQQLRRQELERKF 1725
Query: 1864 VERSALRLEKDRVALRRT---LDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEA 1920
E LR E ++ LRR +E E+LR + +L R +R E E
Sbjct: 1726 REEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLR----RQERDRKFREEEQLRQ 1781
Query: 1921 QRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTE-RTLEARERAH 1979
+R+ QQL +Q + QL + ++QQL QQ + R + Q + E R R
Sbjct: 1782 EREEQQLRSQESD-RKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQE 1840
Query: 1980 RQRVRGLEEQVSTLKGQLQQE 2000
R R EEQ +T + ++E
Sbjct: 1841 RDRQYRAEEQFATQEKSRREE 1861
Score = 231 bits (590), Expect = 4e-60
Identities = 433/1893 (22%), Positives = 770/1893 (40%), Gaps = 208/1893 (10%)
Query: 80 QEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVR 139
+++ +L Q++ R ++ L + R E E + A E+L+ E E +E R
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREER-RAEEEQLQSCKGHETEEFPDEEQLRR-R 213
Query: 140 QSVELRRQLQEEQASYRRKLQ--AYQEGQQRQ--------AQLVQRLQGKILQYKKRCSE 189
+ +ELRR+ +EE+ RR+ Q +QE ++++ + ++LQ + Q ++ E
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQE 273
Query: 190 LEQQL--LERSGELEQQRLRDTEHSQDL--ESALIRLEEEQQRSASLAQVNAMLREQLDQ 245
E+QL LER EL ++R + + Q L E L R +EE++R + R + Q
Sbjct: 274 EEEQLRKLERQ-ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE-QQ 331
Query: 246 AGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVG 305
Q L + + R +E E RE RRE+E + L +Q+
Sbjct: 332 EERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRR 391
Query: 306 FRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQA 365
++L E ++ E+ L + +L R + +E L E + E +Q L +
Sbjct: 392 EQQLRREQQLRREQQLRR-EQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450
Query: 366 QLEEQLRDKVLREKDLA--QQQMQSDLDKADLSARVTELGLAVK---RLEKQNLEKDQVN 420
Q E+ RD + RE++ +Q+ + K D E L ++ R E+Q + Q+
Sbjct: 451 Q--EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLR 508
Query: 421 KDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADAS 480
++ E+ E RL+ Q E+ E LQQ LR Q E QL +R +
Sbjct: 509 REQEERREQ----RLKRQ-----EEEERLQQRLRSEQQLRREQEERREQLL--KREEEKR 557
Query: 481 NGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRG 540
R + RR + RR L +L+ ++ R
Sbjct: 558 LEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERRE 617
Query: 541 RYEASQDLLGTLRKQLSDSESERRALEEQLQR-LRDKTDGAMQAHEDAQREVQRLRSANE 599
+ ++ R+QL SE + ++QL+R +++ + ++ E+ +R QRL+ +E
Sbjct: 618 QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHE 677
Query: 600 LLSREKSNLAHSLQVAQQQAE------------ELRQEREKLQAAQEELRRQRDRLEEEQ 647
RE+ + A+++ + E + K+ + + QR R E+E+
Sbjct: 678 EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737
Query: 648 EDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVA 707
+ ++ +E ER+HRQ ++ E +R + E + R QR + E
Sbjct: 738 KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGR---QRLSARPPLREQR 794
Query: 708 EALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKS 767
E +AE + + + + +E + + L +++L QL+EE+
Sbjct: 795 ERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEED 854
Query: 768 ALQ-GRQRQAEQEATVAREEQERLEELRLEQE---VARQGLEGSLRVAEQAQEALEQQLP 823
LQ ++R+ QE ++ + +LEE R + A+ L+ LR +Q + E++L
Sbjct: 855 GLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQ 914
Query: 824 TLRHERSQLQEQLAQL--SRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGL 881
E+ + QEQ Q QL E++L + RE +R+ E + ++K+ KE
Sbjct: 915 REEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEE--- 971
Query: 882 AVQLVAAEREGRTLSEEATRLRLEKEAL--EGSLFEVQRQLAQLEA------RREQLEAE 933
QL+ E E R E + R E+E E L +R+ + + ++++L+ E
Sbjct: 972 --QLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE 1029
Query: 934 GQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAER-EAQASLREQRAAHE 992
+ LL +E L +Q +E +++L+ ++ R E + R++ +
Sbjct: 1030 EEQLL-REEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQ 1088
Query: 993 EDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSE------EIAALQ 1046
E+ Q L+ E E R+ + + + +LQ+E+E+LL R E EK E E +Q
Sbjct: 1089 EEEQLLREEPEKRRRQERERQCREEEELQQEEEQLL-REEREKRRRQELERQYREEEEVQ 1147
Query: 1047 QERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQE-- 1104
QE +E LL E EK++ L+ + E+L L E RQ+R+ Q R+E
Sbjct: 1148 QE-EEQLLREEPEKRRRQELERQYRE--EEELQQEEEQLLREEQEKRRQERERQYREEEE 1204
Query: 1105 ---QDRSTVNALTSELRDLRAQREEAAAAHAQEVR-----RLQEQARDLGKQRDSCLREA 1156
Q R + DL+ Q E ++ + R EQ R L DS LR+
Sbjct: 1205 LQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQL---EDSQLRDR 1261
Query: 1157 EELRTQLRLLEDARDGLR-RELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREAL 1215
+ + LL + ++ R +E Q++ R E +++R+E E +R + +E++ L
Sbjct: 1262 QSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLL 1321
Query: 1216 RRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSR 1275
R EE R + R +L E +EQ L E R +E QE R
Sbjct: 1322 REEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRH-----QEQGRKF 1376
Query: 1276 LEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGE 1335
LE + L+ R+ K L E +L + E Q R + +E ++ + R R + E
Sbjct: 1377 LEEEQRLRRQERERKFL-KEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFR-E 1434
Query: 1336 ASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKL--EA 1393
+V RQE +RK E+E + R R E+ ++Q H + + K E
Sbjct: 1435 EEQQVRRQE---RERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEE 1491
Query: 1394 ARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPA 1453
+ E + E R+Q E + E Q + Q R L+ L R
Sbjct: 1492 QQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ----RKFLQEEQQLRRQERGQ 1547
Query: 1454 PRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALRE 1513
R RD + + S + L+ + VR +E
Sbjct: 1548 QR----RQDRDRKFREEEQLRQEREEQQLSRQER---------DRKFRLEEQKVRRQEQE 1594
Query: 1514 FLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGR 1573
R + +LR Q ++ ERD QL + E + R+ D +
Sbjct: 1595 -----RKFMEDEQQLRRQEGQ-----QQLRQERDRKFREDEQLLQEREEQQLHRQERDRK 1644
Query: 1574 LSGVQAELALQE-ESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETK 1632
+ +L QE E R +R+R+ + E+ LQ E + QE+ K + E +
Sbjct: 1645 FLEEEPQLRRQEREQQLRHDRDRKFREE-----EQLLQEGEEQQLRRQERDRKFREEEQQ 1699
Query: 1633 LEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQ 1692
L +R K + + + R + EL+R+ E E R + E + Q+R R+
Sbjct: 1700 LRRQERERKFLQEEQQLR--RQELERKFREEEQLR-----QETEQEQLRRQER----YRK 1748
Query: 1693 VADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHL 1752
+ + E QL ER L + E RD+ E L Q ++ L
Sbjct: 1749 ILEEE------QLRPEREEQQLRRQE------RDRKFREEEQLRQ------EREEQQLRS 1790
Query: 1753 QKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQL 1812
Q++ + Q+ QER + Q LR + D + + E + QL
Sbjct: 1791 QESDRKFREEEQLRQER--------------------EEQQLRPQQRDGKYRWEEEQLQL 1830
Query: 1813 QQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLE 1872
++ + LRQ ++ + A +E+ QE+ ++ L Q E +KR R E
Sbjct: 1831 EEQEQRLRQERDRQYRA--------EEQFATQEKSRREEQELWQEEEQKR-------RQE 1875
Query: 1873 KDRVALRRTLDKVEREKLRSHEDTVRLSAEKGR 1905
++R + + ++E+ R H + +++G+
Sbjct: 1876 RERKLREEHIRRQQKEEQR-HRQVGEIKSQEGK 1907
Score = 229 bits (584), Expect = 2e-59
Identities = 371/1494 (24%), Positives = 631/1494 (42%), Gaps = 187/1494 (12%)
Query: 77 LSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRG 136
L QEE + LQQ L R E L + + ER E +K +RLEQ R + + E +E R
Sbjct: 519 LKRQEEEERLQQRL-RSEQQLRREQEERREQLLK-REEEKRLEQERREQRLKREQEERRD 576
Query: 137 LVRQSVELRRQL-----QEEQASYRRKLQAYQ--EGQQRQAQLVQR------LQGKILQY 183
+ + E RRQ QEE+ R K + + E ++R+ Q ++R + ++L+
Sbjct: 577 QLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKS 636
Query: 184 KKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQL 243
+++ +QQL E +QRL+ E + LE L R EE++R LA+ E+
Sbjct: 637 EEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAE------EEQ 690
Query: 244 DQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEES-FNAYFSNEHSRLLLLWRQ 302
+QA R+ ++ R W+ + ES +A S +SR R+
Sbjct: 691 EQA---------------------RERIKSRIPKWQWQLESEADARQSKVYSRP----RK 725
Query: 303 VVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLS-TGLRLAESRAEAA---LE 358
G RR + + R+ E R R QE T AE ++E L
Sbjct: 726 QEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLS 785
Query: 359 KQALLQAQLEEQLR--DKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEK 416
+ L+ Q E QLR ++ RE+ ++ + + + R EL + + Q E+
Sbjct: 786 ARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRER 845
Query: 417 DQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERT 476
Q ++ + L+ + R ++ + + L++ + + + QL ++
Sbjct: 846 AQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQL 905
Query: 477 ADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQ 536
L QR RR R R+ L+ KR+ Q +
Sbjct: 906 LQEEEEEL-----QREEREKRR----RQEQERQYREEEQLQQEEEQLLREEREKRRRQER 956
Query: 537 DMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRS 596
+ + R + L +QL E E+R +E+ ++ R++ E Q E Q LR
Sbjct: 957 ERQYRKDKK---LQQKEEQLLGEEPEKRRRQEREKKYREE-------EELQQEEEQLLRE 1006
Query: 597 ANELLSREKSNLAHSLQVAQQQAEE--LRQEREKLQAAQEELR-RQRDRLEEEQEDAVQD 653
E R++ + + QQ EE LR+EREK + + E + R+ + L++E+E + +
Sbjct: 1007 EREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGE 1066
Query: 654 GARVRR--ELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALT 711
RR ELER +R+ E+L+ + L +E E R R R+ + ++ E E L
Sbjct: 1067 ERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE--EQLL 1124
Query: 712 KAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQG 771
+ E + + + R EE Q+ L E + +L+ Q EE+ Q
Sbjct: 1125 REEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE-----RQYREEEELQQE 1179
Query: 772 RQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRH---- 827
++ +E R+E+ER + R E+E+ RQ + R +Q + Q P +
Sbjct: 1180 EEQLLREEQEKRRQERER--QYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRD 1237
Query: 828 ----------------ERSQLQEQLAQLSRQ-LSGREQE--LEQARREAQR------QVE 862
E SQL+++ +Q Q L G +QE EQ RR Q+ + E
Sbjct: 1238 NKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEE 1297
Query: 863 ALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL--EGSLFEVQRQL 920
LER +++ + QL+ ERE + +E R E+E L E ++RQ
Sbjct: 1298 QLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQE 1357
Query: 921 AQLEARREQL--EAEGQALLLAKETL---------TGELAGLRQQIIATQEKASLDKELM 969
+ R E+L + +G+ L ++ L E LR Q Q + D++
Sbjct: 1358 RDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFR 1417
Query: 970 --AQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEEL 1027
Q+L + ER+ + EQ+ +E ++ E++ +E + + + LQ +E+
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQ 1477
Query: 1028 LARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLAT 1087
L R E +++ L EE +QERD ++Q L +E E+ L E+ R
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDRKF------REQELRSQEPERKFLEEEQQLHRQQRQR 1531
Query: 1088 ISLEME----RQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVR--RLQEQ 1141
L+ E RQ+R Q RQ++DR E LR +REE + + R RL+EQ
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRK-----FREEEQLRQEREEQQLSRQERDRKFRLEEQ 1586
Query: 1142 ARDLGKQRDSCLREAEELRTQ--LRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAG 1199
+Q + + ++LR Q + L RD R+ E ++ L+E +E +++ RQE
Sbjct: 1587 KVRRQEQERKFMEDEQQLRRQEGQQQLRQERD---RKFREDEQLLQEREE-QQLHRQERD 1642
Query: 1200 --------ELRRSLGEG--AKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLAL 1249
+LRR E +R+ R E+L ++ + R ++EQ+L
Sbjct: 1643 RKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRR 1702
Query: 1250 LEEARTAVGKE----AGELRTGLQEVERSRLEARRE-LQELRRQMKMLDSENTRLGRELA 1304
E R + +E EL +E E+ R E +E L+ R K+L+ E R RE
Sbjct: 1703 QERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQ 1762
Query: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASL-----EVMRQELQVAQRKLQEQEGEF 1359
+L+ + + E+E R+ Q+L E+ E +RQE + Q + Q+++G++
Sbjct: 1763 QLRRQERDRKFREEEQLRQERE-EQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKY 1821
Query: 1360 RTRERRLLGSLEEARGTEKQQLDHARGLELKL---EAARAEAAELGLRLSAAEGRAQGLE 1416
R E +L LEE +Q+ D E + E +R E EL + R Q E
Sbjct: 1822 RWEEEQL--QLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELW--QEEEQKRRQERE 1877
Query: 1417 AELARVEVQRRAAE----AQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAP 1466
+L ++R+ E Q+G ++S + G G GR P P R +P
Sbjct: 1878 RKLREEHIRRQQKEEQRHRQVGEIKS--QEGKGHGRLLEPGTHQFASVPVRSSP 1929
Score = 216 bits (549), Expect = 2e-55
Identities = 333/1348 (24%), Positives = 547/1348 (40%), Gaps = 189/1348 (14%)
Query: 746 ESLAQDKL---DLNRLVA---QLEEEKSALQGRQRQAEQEATVAR-----EEQERLEEL- 793
ESL QD+ D R QLEEE + RQ++ EQE +A E+QERLE+
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDRQLEEEPGQRR-RQKRQEQERELAEGEEQSEKQERLEQRD 165
Query: 794 --RLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ---LSRQLSGREQ 848
R ++E+ RQ E R +A+E Q E +EQL + L + GRE+
Sbjct: 166 RQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE 225
Query: 849 ELEQARREAQRQV--EALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEK 906
+ +Q RRE Q +V E E+ R++E + + +E L EE + + E
Sbjct: 226 K-QQQRRERQDRVFQEEEEKEWRKRETVLR-------------KEEEKLQEEEPQRQREL 271
Query: 907 EALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDK 966
+ E L +++RQ E RRE+ E E Q L +E QQ+ QE+ ++
Sbjct: 272 QEEEEQLRKLERQ----ELRRERQEEEQQQQRLRRE----------QQLRRKQEEERREQ 317
Query: 967 ELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEE 1026
+ + RE Q +Q E+ L+R Q E+ E E + + QL+REQEE
Sbjct: 318 Q-------EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE 370
Query: 1027 LLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLA 1086
+ +E+ ++ QQ R E L E + ++ L+ ++ ++L +
Sbjct: 371 ERREQQLRREQ---QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ--- 424
Query: 1087 TISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQ------- 1139
+ E E ++ + + QE+ + E RD +REE H QE R+ Q
Sbjct: 425 -LRREQEEERHEQKHEQERREQRLKREQEERRDW-LKREEETERHEQERRKQQLKRDQEE 482
Query: 1140 -----------EQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQ 1188
E+ R+ ++R+ LR +E R + RL + ++ L ++++LR Q
Sbjct: 483 ERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQ 542
Query: 1189 EGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLA 1248
E R Q + E +R E ++R L+R EE R + K E ER +L E +E+
Sbjct: 543 EERREQLLKREEEKRLEQERREQR--LKREQEERRDQLLKREEERRQQRLKREQEERLEQ 600
Query: 1249 LL--EEARTAVGKEAGELRTGLQEVERSRLEA---------------RRELQELRRQMKM 1291
L EE +E E R +E E R + RRE QE R Q
Sbjct: 601 RLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK 660
Query: 1292 LDSENTRLGRELA-ELQGRLALGERAEKESRRETLGLRQRLLKGEASLE----------V 1340
+ E RL + L E + E AE+E + ++ R+ K + LE
Sbjct: 661 REEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVY 720
Query: 1341 MRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAE 1400
R Q QR+ QEQE + R RE L EE ++Q+ + R + +A E +E
Sbjct: 721 SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAE--EKSE 778
Query: 1401 LGL-RLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPG 1459
G RLSA + E +L E Q+R R +P
Sbjct: 779 RGRQRLSARPPLREQRERQLRAEERQQREQ-------------------------RFLPE 813
Query: 1460 SPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELR 1519
++ E LE Q L + R +E ++ +
Sbjct: 814 EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873
Query: 1520 ---SAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSG 1576
+ ER R A ++ E+ +LQ+ E E+ RR R
Sbjct: 874 WRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE--EREKRRRQEQERQYR 931
Query: 1577 VQAELALQEESVRRSERERRATLD---------QVATLERSLQATESELRASQEKISKMK 1627
+ +L +EE + R ERE+R + ++ E L E E R QE+ K +
Sbjct: 932 EEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Query: 1628 ANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVD 1687
E + +++ L+E + + R + E Q R + ELQ+ L E + + LQ+R
Sbjct: 992 EEEELQQEEEQLLRE--EREKRRRQEWERQYRK-KDELQQEEEQLLREEREKRRLQER-- 1046
Query: 1688 SLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVR---GLTEALAQSSASLNS 1744
+RQ + E LQ E+L G EE E R ++ E L Q L
Sbjct: 1047 --ERQYREEE----ELQQEEEQLLG-----EERETRRRQELERQYRKEEELQQEEEQLLR 1095
Query: 1745 TRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQ 1804
+ Q+ C + ++ QE R+ + R+Q E+ EV E Q
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL---ERQYREEEEVQQEEEQ 1152
Query: 1805 RVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREV 1864
+ E + ++ +E+ RQ +E E Q L++E+ ++R +R + E +R+
Sbjct: 1153 LLREEPEKRRRQELERQYREEEELQQEEEQLLREEQ---EKRRQERERQYREEEELQRQK 1209
Query: 1865 ERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQI 1924
+ R E R L+ + + +R ++ V + R L ++L ++Q+ +
Sbjct: 1210 RKQRYRDEDQRSDLKWQWEPEKENAVR--DNKVYCKGRENEQFRQLEDSQLRDRQSQQDL 1267
Query: 1925 QQL--EAQVVVLEQSHSPAQLEVD--AQQQQLELQQEVE-RLRSAQAQTERTLEARERAH 1979
Q L E Q EQ Q +++QLE +++ E + R ++Q E+ L ER
Sbjct: 1268 QHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREE 1327
Query: 1980 RQR----VRGLEEQVSTLKGQLQQELRR 2003
++R R E+ L+ + +Q LRR
Sbjct: 1328 KRRRQETDRKFREEEQLLQEREEQPLRR 1355
Score = 201 bits (510), Expect = 8e-51
Identities = 342/1391 (24%), Positives = 590/1391 (42%), Gaps = 185/1391 (13%)
Query: 95 DLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQAS 154
DL + R + +E + V++ AL G E + R ++S+ R+ +E+Q
Sbjct: 62 DLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRR 121
Query: 155 YR-RKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRL-RDTEHS 212
+ R Q +E QR+ Q Q + ++ + +++ SE +++L +R + + L R +
Sbjct: 122 FEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ-SEKQERLEQRDRQRRDEELWRQRQEW 180
Query: 213 QDLESALIRLE---------------EEQQRSASLAQVNAMLREQLDQAGSANQ--ALSE 255
Q+ E E EEQ R L ++ RE+ Q Q E
Sbjct: 181 QEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQE 240
Query: 256 DIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKM 315
+ K +W + L E + EE E +L L RQ + R E +
Sbjct: 241 EEEK---EWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQ 297
Query: 316 FTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKV 375
R QL + R QE E R E L ++ + + E+QLR +
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQ--EERREQQLRRE- 354
Query: 376 LREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRL 435
+E++ +QQ++ + ++ R +L + +Q L ++Q + ++L + LR
Sbjct: 355 -QEEERREQQLRREQEE---ERREQQLRREQQLRREQQLRREQQLR-REQQLRREQQLRR 409
Query: 436 QEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSP 495
++Q E QQ R+ + E Q ER L+ +R
Sbjct: 410 EQQLRRE-------QQLRREQQLRREQEEERHEQKHEQERREQ----RLKREQEERRDWL 458
Query: 496 PRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQ 555
R R RR K+QL+ R + E ++ L ++
Sbjct: 459 KREEETERHEQERR--------------------KQQLK----RDQEEERRERWLKLEEE 494
Query: 556 LSDSESERRALEEQLQR-LRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQV 614
+ ERR E+QL+R ++ + ++ E+ +R QRLRS +L ++ L+
Sbjct: 495 ERREQQERR--EQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR 552
Query: 615 AQQQAEELRQEREKLQAAQEELR---------RQRDRLEEEQEDAVQDGARVRRELERSH 665
+++ E + ++L+ QEE R R++ RL+ EQE+ ++ + R E+ER
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK-REEVER-- 609
Query: 666 RQLEQLEGKRSVLAKELVEV--REALSRATLQRD----MLQAEKAEVAEALTKAEAGRVE 719
LEQ E + L +E E R+ L ++ Q + L+ E+ E E K E
Sbjct: 610 --LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEER 667
Query: 720 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLD--LNRLVAQLEEEKSALQGR--QRQ 775
LE + + EE Q+ L+ + A++++ + + QLE E A Q + R
Sbjct: 668 LEQRLKREHEEERREQE----LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRP 723
Query: 776 AEQEATVAREEQE-----RLEELRLEQE--VARQGLEGSLR-------VAEQAQEALEQQ 821
+QE R+EQE R EL+ ++E RQ E R AE+ E Q+
Sbjct: 724 RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQR 783
Query: 822 L---PTLRHERS-QLQ-EQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAK 876
L P LR +R QL+ E+ Q ++ E+E EQ RR+ + + + L+ E++ +
Sbjct: 784 LSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRR 843
Query: 877 EHAGLAVQLVAAEREG------RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQL 930
E A Q + E +G R S+E R + + LE + L A +EQL
Sbjct: 844 ERA----QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL 899
Query: 931 EAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQ---KLVQAERE-------- 979
E Q L +E L E R++ QE+ ++E + Q +L++ ERE
Sbjct: 900 RKEQQLLQEEEEELQREEREKRRR--QEQERQYREEEQLQQEEEQLLREEREKRRRQERE 957
Query: 980 ------AQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEA 1033
+ +E++ EE +R ++E+E +RE E E Q + QL RE+ E R E
Sbjct: 958 RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYRE-EEELQQEEEQLLREEREKRRRQEW 1016
Query: 1034 E-----KEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATI 1088
E K+EL +E L +E E L E E+Q +E E E+L+G
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERERQYR---EEEELQQEEEQLLGEERETRR- 1072
Query: 1089 SLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQ 1148
E+ERQ R + Q+++ L E R Q E +E+++ +EQ L ++
Sbjct: 1073 RQELERQYRKEEELQQEEE---QLLREEPEKRRRQERERQCREEEELQQEEEQL--LREE 1127
Query: 1149 RDSCLREAEELRTQLRLLEDAR---DGLRRELLEAQRKL---RESQEGREVQRQEAGELR 1202
R+ R +EL Q R E+ + + L RE E +R+ R+ +E E+Q++E LR
Sbjct: 1128 REK--RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185
Query: 1203 RSLGEGAKEREALRRSNEELRSAVKKA----ESERISLKLANEDKEQKLALLEEARTAVG 1258
+ +ERE R EEL+ +K E +R LK E E++ A+ + G
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWE-PEKENAVRDNKVYCKG 1244
Query: 1259 KEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEK 1318
+E + R L++ + +++++LQ L + + D E R R + E+ E+
Sbjct: 1245 RENEQFRQ-LEDSQLRDRQSQQDLQHLLGEQQERDREQER--RRWQQRDRHFPEEEQLER 1301
Query: 1319 ESRRETLGLRQRLLKGEASLEVMRQE------LQVAQRKLQEQEGEFRTRERRLLGSLEE 1372
E ++E ++R K + +++R+E Q RK +E+E + RE + L E
Sbjct: 1302 EEQKEA---KRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER 1358
Query: 1373 ARGTEKQQLDH 1383
R +++L H
Sbjct: 1359 DRKFREEELRH 1369
Score = 199 bits (505), Expect = 3e-50
Identities = 344/1450 (23%), Positives = 594/1450 (40%), Gaps = 143/1450 (9%)
Query: 608 LAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQ 667
+A + A QA L +E+ +E L + R R EE+Q ++ E + RQ
Sbjct: 81 VAQACYYALGQATGLDEEKRARCDGKESLLQDR-RQEEDQRRFEPRDRQLEEEPGQRRRQ 139
Query: 668 LEQLEGKRSVLAKELVEVREALSRATLQR--DMLQAEKAEVAEALTKAEAGRVELELSMT 725
Q + + +E E +E L + QR + L ++ E E + E E +L
Sbjct: 140 KRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQE---REERRAEEEQLQSC 196
Query: 726 K-LRAEEASLQDSLSKLSALN------ESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQ 778
K EE ++ L + L E Q + + V Q EEEK + R+R+
Sbjct: 197 KGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEK---EWRKRE--- 250
Query: 779 EATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ 838
TV R+E+E+L+E +++ Q E LR E+ + LR ER + ++Q +
Sbjct: 251 --TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE---------LRRERQEEEQQQQR 299
Query: 839 LSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 898
L R+ R ++ E+ R + + + E ER +++E ++ RE E+
Sbjct: 300 LRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ----------LRREQEERREQ 349
Query: 899 ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIAT 958
R E+E E L Q + E R +QL E Q L ++ L E R+Q +
Sbjct: 350 QLRREQEEERREQQLRREQEE----ERREQQLRREQQ--LRREQQLRREQQLRREQQLRR 403
Query: 959 QEKASLDKELMAQKLVQAE----REAQASLREQRAAHEEDLQRLQREKEAAWRELEAERA 1014
+++ +++L ++ ++ E RE + EQ+ E QRL+RE+E L+ E
Sbjct: 404 EQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEE 463
Query: 1015 QLQSQLQREQEELLARLEAEKEE----LSEEIAALQQERDEGLLLAESEKQQALSLKESE 1070
+ + +R +++L E E+ E L EE QQER E L E E+++ LK E
Sbjct: 464 TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE 523
Query: 1071 KTALSEKLMGTRHSLATISLEMERQ--KRDAQSRQEQDR--STVNALTSELRDLRAQREE 1126
+ ++ + + L E Q KR+ + R EQ+R + E RD +REE
Sbjct: 524 EEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREE 583
Query: 1127 AAAAHAQEVRRLQEQARDLGKQRDSCLR-EAEELRTQLRLLEDARDGLRRELLEAQRKLR 1185
Q ++R QE+ + +R+ R E EE R Q E+ + R++LL++
Sbjct: 584 ER--RQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKS----- 636
Query: 1186 ESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKA-ESERISLKLANEDKE 1244
E QE R Q +LRR E ++R E L +K+ E ER +LA E++E
Sbjct: 637 EEQEERRQQ-----QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691
Query: 1245 QKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELA 1304
Q E ++ + K +L + + +S++ +R QE +R+ + + + R EL
Sbjct: 692 QAR---ERIKSRIPKWQWQLESEA-DARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ 747
Query: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER 1364
+ A ++ E+E RR+ Q K E RQ L A+ L+EQ RER
Sbjct: 748 WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG----RQRLS-ARPPLREQ------RER 796
Query: 1365 RLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEV 1424
+L EE + E++ L E + R EL Q LE E ++
Sbjct: 797 QLRA--EERQQREQRFLPEEEEKEQRRRQRREREKEL-----------QFLEEE---EQL 840
Query: 1425 QRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSP 1484
QRR QL L+ R+ + P+ E
Sbjct: 841 QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900
Query: 1485 GSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEA 1544
Q + + + R++ +E + Q E LR + RQ E +
Sbjct: 901 KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY 960
Query: 1545 ERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERR-------- 1596
+D + + Q E E+ RR + + EL +EE + R ERE+R
Sbjct: 961 RKDKKLQQKEE-QLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQ 1019
Query: 1597 -ATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLE 1655
D++ E L E E R QE+ + + E + +++ L E + R +LE
Sbjct: 1020 YRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGE--ERETRRRQELE 1077
Query: 1656 LQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV-ADSEVKAGTLQLTVERLNGAL 1714
Q R E ELQ+ L E + + Q+R +RQ + E++ QL E
Sbjct: 1078 RQYRK-EEELQQEEEQLLREEPEKRRRQER----ERQCREEEELQQEEEQLLREEREKRR 1132
Query: 1715 AKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAAR 1774
+ E + ++V+ E L + ++ ++ + + Q+L+E + R
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192
Query: 1775 QALSEARKQSSSLGEQVQTLR----GEVADLELQ-RVEAEGQLQQLR--------EVLRQ 1821
Q ++ L Q + R + +DL+ Q E E ++ + E RQ
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQ 1252
Query: 1822 RQEGEAAALNTVQKL------QDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDR 1875
++ + + Q L Q ER QER QR E E+ E E +DR
Sbjct: 1253 LEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDR 1312
Query: 1876 VAL-RRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVL 1934
+ + L + ERE+ R ++T R E+ +L + L E R+ ++ E +
Sbjct: 1313 KSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQ 1372
Query: 1935 EQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLK 1994
+ + + Q+++ + +E ++LR Q + ++ + R+R R+ + L Q K
Sbjct: 1373 GRKFLEEEQRLRRQERERKFLKEEQQLR-CQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431
Query: 1995 -GQLQQELRR 2003
+ +Q++RR
Sbjct: 1432 FREEEQQVRR 1441
Score = 84.0 bits (206), Expect = 1e-15
Identities = 128/539 (23%), Positives = 222/539 (41%), Gaps = 54/539 (10%)
Query: 1516 QELRSAQRERDELRTQTSALNRQ-LAEMEAERDSATSRARQLQKAVAESEEARRSVDGRL 1574
+E QRE E Q L RQ L E + R R+ Q+ + EE RR
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321
Query: 1575 SGVQAELALQEE----SVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANE 1630
Q QEE +RR + ERR +Q E+ + E +LR QE+ + + +
Sbjct: 322 REQQERREQQEERREQQLRREQEERR---EQQLRREQEEERREQQLRREQEE--ERREQQ 376
Query: 1631 TKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQ 1690
+ E RR +++ + R + + + L E Q R RE Q + Q+ +
Sbjct: 377 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQE--EERH 434
Query: 1691 RQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNL 1750
Q + E + L+ E L + EE+E R + + L + R L
Sbjct: 435 EQKHEQERREQRLKREQEERRDWLKREEETE---RHEQERRKQQLKRDQEEERRERWLKL 491
Query: 1751 HLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQV---QTLRGEVADL------ 1801
++ E Q L+ + R+ + +++ L +++ Q LR E +
Sbjct: 492 EEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK 551
Query: 1802 --ELQRVEAEGQLQQLR--------EVLRQRQEGEAAALNTVQKLQDERRLLQE---RLG 1848
E +R+E E + Q+L+ ++L++ +E L Q+ + E+RL +E RL
Sbjct: 552 REEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLE 611
Query: 1849 SLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDR 1908
+R +L+ E+ E ER L+ + RR ++ RE+ E ++ E+ RL++
Sbjct: 612 QEERREQRLKREEPEEERRQQLLKSEEQEERRQ-QQLRREQQERREQRLKREEEEERLEQ 670
Query: 1909 TLTGAELELAEAQRQIQQLEAQVVVLEQSHSPA---QLEVDAQQQQLEL-----QQEVER 1960
L E Q ++ + Q +S P QLE +A +Q ++ +QE +R
Sbjct: 671 RLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQR 730
Query: 1961 LRSAQAQTERTLEAR------ERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPFS--PP 2011
R Q + R E+ ERAHRQ+ + + T + Q +++ R S PP
Sbjct: 731 RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPP 789
Score = 75.9 bits (185), Expect = 4e-13
Identities = 114/501 (22%), Positives = 209/501 (41%), Gaps = 75/501 (14%)
Query: 1512 REFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVD 1571
R+FL+E + ++ER + L ++ E + R + + ++ + E R+ +
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFRE 1505
Query: 1572 GRLSGVQAELAL--QEESVRRSERERRATLD--QVATLERSLQATES-ELRASQEKISKM 1626
L + E +E+ + R +R+R+ + Q+ ER Q + + + +E+ +
Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ 1565
Query: 1627 KANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRV 1686
+ E +L +R K L+ E + + E +R+ +E E Q R +E Q Q Q+R
Sbjct: 1566 EREEQQLSRQERDRKFRLE--EQKVRRQEQERKFMEDEQQLRR-----QEGQQQLRQER- 1617
Query: 1687 DSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTR 1746
R+ + E QL ER L + E L +
Sbjct: 1618 ---DRKFREDE------QLLQEREEQQLHRQERDRKFLEE-------------------- 1648
Query: 1747 DKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRV 1806
+ L Q+ HDR + Q L E +Q E+ + R E + +L+R
Sbjct: 1649 EPQLRRQEREQQLRHDR---DRKFREEEQLLQEGEEQQLRRQERDRKFREE--EQQLRRQ 1703
Query: 1807 EAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVER 1866
E E + Q + LR RQE E +K ++E +L QE + Q L + E ++ +E
Sbjct: 1704 ERERKFLQEEQQLR-RQELE-------RKFREEEQLRQE---TEQEQLRRQERYRKILEE 1752
Query: 1867 SALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRL-----DRTLTGAELELAEAQ 1921
LR E++ LRR ER++ E+ +R E+ +L DR E E +
Sbjct: 1753 EQLRPEREEQQLRRQ----ERDRKFREEEQLRQEREEQQLRSQESDRKF--REEEQLRQE 1806
Query: 1922 RQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQ 1981
R+ QQL Q + QL+++ Q+Q+L + R Q + E +E++ R+
Sbjct: 1807 REEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQE------RDRQYRAEEQFATQEKSRRE 1860
Query: 1982 RVRGLEEQVSTLKGQLQQELR 2002
+E+ + + +++LR
Sbjct: 1861 EQELWQEEEQKRRQERERKLR 1881
Score = 68.9 bits (167), Expect = 5e-11
Identities = 105/463 (22%), Positives = 198/463 (42%), Gaps = 77/463 (16%)
Query: 1512 REFLQE---LRSAQRERDELRTQTSALNRQLAEMEAE-RDSATSRARQLQKAVAESEEAR 1567
R+FL+E L QR+R L+ + ++ + + RD QL++ E + +R
Sbjct: 1515 RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSR 1574
Query: 1568 RSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMK 1627
+ D + L+E+ VRR E+ER+ D E+ L+ E + + QE+ K +
Sbjct: 1575 QERDRKFR-------LEEQKVRRQEQERKFMED-----EQQLRRQEGQQQLRQERDRKFR 1622
Query: 1628 ANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVD 1687
+E L+ + E + + E R+ LE E Q R +RE Q + +DR
Sbjct: 1623 EDEQLLQ----------EREEQQLHRQERDRKFLEEEPQLRR---QEREQQLRHDRDRKF 1669
Query: 1688 SLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRD 1747
+ Q+ + + +R K E E LR + R
Sbjct: 1670 REEEQLLQEGEEQQLRRQERDR------KFREEEQQLRRQER----------------ER 1707
Query: 1748 KNLHLQKALTACEHDRQVLQE---RLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQ 1804
K L ++ L E +R+ +E R + ++ L + L E+ LR E + +L+
Sbjct: 1708 KFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEE--QLRPEREEQQLR 1765
Query: 1805 RVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREV 1864
R E + + ++ ++ ++R+E + + + +K ++E +L QER Q+ Q K
Sbjct: 1766 RQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQER--EEQQLRPQQRDGKYRW 1823
Query: 1865 ERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQI 1924
E L+LE+ LR+ D+ + R+ E + EK R + EL E Q++
Sbjct: 1824 EEEQLQLEEQEQRLRQERDR----QYRAEEQFA--TQEKSRREE----QELWQEEEQKRR 1873
Query: 1925 QQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQ 1967
Q+ E + L + H + QQ++ + ++V ++S + +
Sbjct: 1874 QERERK---LREEH------IRRQQKEEQRHRQVGEIKSQEGK 1907
Score = 39.3 bits (90), Expect = 0.039
Identities = 43/175 (24%), Positives = 79/175 (45%), Gaps = 13/175 (7%)
Query: 72 EMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELET 131
E L +EE QL QE R Q R ER+E ++ ++ + R E +L+
Sbjct: 1775 EEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLR----PQQRDGKYRWEEEQLQL 1830
Query: 132 QEPRGLVRQSVELRRQLQE----EQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRC 187
+E +RQ + + + +E ++ S R + + +QE +Q++ Q +R K+ + R
Sbjct: 1831 EEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERER---KLREEHIRR 1887
Query: 188 SELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQ 242
+ E+Q + GE++ Q + H + LE + RS+ L + R Q
Sbjct: 1888 QQKEEQRHRQVGEIKSQEGKG--HGRLLEPGTHQFASVPVRSSPLYEYIQEQRSQ 1940
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 222 bits (566), Expect = 3e-57
Identities = 407/1990 (20%), Positives = 787/1990 (39%), Gaps = 291/1990 (14%)
Query: 8 AQEVELTLETVIQTLESSVLCQEK-GLGARDLAQDAQITSLPALIRE--IVTRNLSQPES 64
A++VEL L+ T E + +E L + Q +I SL + E + +L Q
Sbjct: 1316 AEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLE 1375
Query: 65 PVLLPATEMASLLSLQEENQLLQQELSRVED---LLAQSRAERDELAIKYNAVSERLEQA 121
L + L LQ + LQ+ +S+ E+ L+ +E++ K E
Sbjct: 1376 SSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDL 1435
Query: 122 LRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKIL 181
++ +LE Q ++ E +QLQ E ++K + E + + Q+ ++LQ ++
Sbjct: 1436 IKALHTQLEMQ-----AKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALI 1490
Query: 182 QYKKRCSE---LEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQ----RSASLAQ 234
K+ E L+++L G +E R T+ D+ES + +E+ R A L +
Sbjct: 1491 SRKEALKENKSLQEELSLARGTIE----RLTKSLADVESQVSAQNKEKDTVLGRLALLQE 1546
Query: 235 VNAMLREQLDQAGSANQALSED-------IRKVTNDWTRCRKELEHREA---AWRREEES 284
L ++D++ NQ+LS + +T D + KE+E ++ A E +
Sbjct: 1547 ERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQE 1606
Query: 285 FNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLST 344
+ E+ LL + V + V ++ +L G+L T +E L
Sbjct: 1607 KHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQE 1666
Query: 345 GLRLAESRAE-----AALEKQALLQAQLE-EQLRDKVLREKDLAQQQMQSDLD-----KA 393
+ E E A ++Q +L+ + E ++LR +V D A++ M++ L K
Sbjct: 1667 AEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKE 1726
Query: 394 DLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTL 453
+L E K+ + EKD +++++ + +E + +QA LE + Q +
Sbjct: 1727 ELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEG-NVSKQANLEATEKHDNQTNV 1785
Query: 454 RDLAQAVLSDSESGVQ-LSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPS 512
+E G Q + G D+ + S R + PS + +
Sbjct: 1786 ----------TEEGTQSIPGETEEQDSLSMSTRPTCSESVPSA-------------KSAN 1822
Query: 513 PACSDSSTLALIHSALHKRQLQVQDMRGRY-----------EASQDL---LGTLRKQLSD 558
PA S + H ++ Q+ ++ R E SQ L TL Q+S
Sbjct: 1823 PAVSKDFSS---HDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIST 1879
Query: 559 SESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSL--QVAQ 616
+ E + L+E++ ++ ++ Q E+ R+ E EK +L L Q+A+
Sbjct: 1880 KDGELKMLQEEVTKMN-------LLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAE 1932
Query: 617 ---------QQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQ 667
Q + + + E L++ + L++ LEEE++ V++ +V E+ + +
Sbjct: 1933 LNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEY-- 1990
Query: 668 LEQLEG--KRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMT 725
LE+++G K E++E L + LQ + E ++ E LE T
Sbjct: 1991 LEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQT 2050
Query: 726 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQ----EAT 781
+S L E+LAQ + A+L K L Q +A +
Sbjct: 2051 ----------ESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLK 2100
Query: 782 VAREEQERLEELRLEQEVARQGLEGSLRVAEQA----QEALEQQLPTLRHERSQLQEQLA 837
+ +E Q E ++ + + + LE L AE+ ++ ++++L LR E+ L+E +
Sbjct: 2101 LKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIG 2160
Query: 838 QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAERE-GRTLS 896
++ L+ +++E++Q + V L + +L + + + ER+ +
Sbjct: 2161 EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ 2220
Query: 897 EEATRLRLEKE---ALEGSLFEVQRQLAQLEARREQLE---------AEGQALLLAK--E 942
+ +RL+++ L+ L ++ + +L+ +LE A+ + L K +
Sbjct: 2221 SKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD 2280
Query: 943 TLTGELAGLRQQIIATQ--------EKASLDKELMAQK--------LVQAEREAQASLRE 986
TL GE L Q+ T+ E A L+ EL + K ++ +E + +L
Sbjct: 2281 TLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEG 2340
Query: 987 QRAAHEEDLQRLQREKEAAWRELEAER---AQLQSQLQREQEELLARLEAEKEELSEEIA 1043
E D+Q + E +L+A R ++L ++ +++++++ L ++E + IA
Sbjct: 2341 IIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIA 2400
Query: 1044 ALQQERDEGLL----LAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDA 1099
L+Q+ D+ + L E+++ + L+E K A+ +K +L TI E +QK
Sbjct: 2401 ELRQQHDKEIKELENLLSQEEEENIVLEEENKKAV-DKTNQLMETLKTIKKENIQQKAQL 2459
Query: 1100 QS--------RQEQDRSTVNALTSELRDLRAQRE------EAAAAH---AQEVRRLQEQA 1142
S + ++DR + E R L E EAAA + +E+R L+
Sbjct: 2460 DSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHM 2519
Query: 1143 RDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQ---------------RKLRES 1187
DL + E + R L + +D +++LLE Q KL+ES
Sbjct: 2520 DDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKES 2579
Query: 1188 QEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESE------RISLKLANE 1241
+E E R+ L+ + +KE E+L+ S +L V + E LK+ E
Sbjct: 2580 EEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEE 2639
Query: 1242 D----------KEQKLALLEEARTAVGKEAGELRTGLQEVERSRLE-ARRELQELRRQMK 1290
+ ++++A LEE V KEA + +++ + L+ + +R + +
Sbjct: 2640 EVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETE 2699
Query: 1291 MLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQR 1350
+ L R+L E++ +L + + K + + + + S + +EL +R
Sbjct: 2700 TAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKR 2759
Query: 1351 K----------LQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAE 1400
K L+EQ R R+ L + TE+ L H L +L + +
Sbjct: 2760 KYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLH 2819
Query: 1401 LGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGS 1460
L +L + + Q +A ++ +R +L R +
Sbjct: 2820 LSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKS--------------------- 2858
Query: 1461 PARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRS 1520
G Q + P+TSPA + ++++ A+ +
Sbjct: 2859 ----------------------EEGKQRSAAQPSTSPA----EVQSLKKAMSSLQNDRDR 2892
Query: 1521 AQRERDELRTQTSALNRQLAEM---EAERDSATSRARQLQKAVAESEEARRSVDGRLSGV 1577
+E L+ Q +N+++ E+ +A+ + + Q E + S L +
Sbjct: 2893 LLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQL 2952
Query: 1578 QAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDK 1637
+ E + E RR + + + LQ ELR+S + +K + +
Sbjct: 2953 RMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPE 3012
Query: 1638 RRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSE 1697
D S++ + EL R L L+ + +E + Q L L +
Sbjct: 3013 TSASP--DGSQNLVYETELLRTQLNDSLKE----IHQKELRIQQLNSNFSQLLEE----- 3061
Query: 1698 VKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSAS-LNSTRDKNLHLQKAL 1756
TL + + + +L + ++ G L + L + + + A LN +K
Sbjct: 3062 --KNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNG 3119
Query: 1757 TACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLR 1816
+ D + L+E +Q+ SEA++Q + ++V LR + + QRV AE L
Sbjct: 3120 VHRKSDPEELRE----PQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAE 3175
Query: 1817 EVLRQRQEGE 1826
E +R+ + E
Sbjct: 3176 EQIRRLEHSE 3185
Score = 218 bits (554), Expect = 6e-56
Identities = 412/2034 (20%), Positives = 851/2034 (41%), Gaps = 241/2034 (11%)
Query: 59 LSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERL 118
LS+ +L E++ + L+ + + L+ L+ E Q R + + N ++E++
Sbjct: 742 LSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAE---RQRRLDYESQTAHDNLLTEQI 798
Query: 119 EQAL---------------RLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQ 163
L+ +L+ E L+R L+ QLQ +++ + +
Sbjct: 799 HSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRS---LQSQLQNKESEVLEGAERVR 855
Query: 164 EGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELE--QQRLRD-----TEHSQDLE 216
+ +L Q L K L+ K ++Q LLE+ ++E QQ + + TE S +
Sbjct: 856 HISSKVEELSQALSQKELEITK----MDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMT 911
Query: 217 SALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREA 276
+++L EE+ SL L+EQL+ A +A E + + + ++ +
Sbjct: 912 EKMVQLNEEK---FSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSP 968
Query: 277 AWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQ 336
A + +E F L ++ R+ + + ++LLQ R SR +
Sbjct: 969 AGQISKEELQHEFD--------LLKKENEQRKRKLQAALINRKELLQ------RVSRLEE 1014
Query: 337 EAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLS 396
E A L+ ++ + L E R +V +K+ + + ++
Sbjct: 1015 EL----------------ANLKDESKKEIPLSETERGEVEEDKE------NKEYSEKCVT 1052
Query: 397 ARVTELGLAVKR-LEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLR- 454
++ E+ + +K+ + ++ +E + KDL EKL A E + AL + + LQ
Sbjct: 1053 SKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ-----ALVKQMNQTLQDKTNQ 1107
Query: 455 -DLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSP 513
DL QA +S++++ +Q + T DAS+G L + P P G S P
Sbjct: 1108 IDLLQAEISENQAIIQKLITSNT-DASDGDSVALVKETVVISP----PCTGSSEHWKPE- 1161
Query: 514 ACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRL 573
+ LAL K QLQ + Q+ L + + L ++ + R L E+L++
Sbjct: 1162 --LEEKILAL---EKEKEQLQ--------KKLQEALTSRKAILKKAQEKERHLREELKQQ 1208
Query: 574 RDKTDGAMQAHEDAQREVQRLRSA-NELLSREKSNLAHSLQVAQQQ--AEELRQEREKLQ 630
+D + + ++ +E + + +L + + ++ L QQ E L
Sbjct: 1209 KDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLF 1268
Query: 631 AAQEELRRQ---RDRL------EEEQEDAVQDG---ARVRRELERSHRQLEQLEGKRSVL 678
A E+ Q L E A+Q G A+++ +L+ + +LE K S
Sbjct: 1269 KATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSST 1328
Query: 679 AKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSL 738
EL + E + + ++ + + E+ T + V E KL E + LQ +
Sbjct: 1329 TSELTKKSEEVFQL---QEQINKQGLEIESLKTVSHEAEVHAESLQQKL--ESSQLQ--I 1381
Query: 739 SKLSALNESLAQDKLD-LNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQ 797
+ L L E Q KLD L +L+++ EE+ S L G+ +E+EA + + + E +E+ L +
Sbjct: 1382 AGLEHLRE--LQPKLDELQKLISKKEEDVSYLSGQL--SEKEAALTKIQTEIIEQEDLIK 1437
Query: 798 EVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLA---QLSRQLSGREQELEQAR 854
+ Q LE + ++ + L+ +L ++ + ++ E+ Q+ R+L ++A
Sbjct: 1438 ALHTQ-LEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEAL 1496
Query: 855 REAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLF 914
+E + E L A E L K A + Q+ A +E T+ L+ E++ L +
Sbjct: 1497 KENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKL---IT 1553
Query: 915 EVQRQLAQ---LEARREQLEAEGQALLLAKETLTGELAGLRQQIIA-TQEKASLDKELMA 970
E+ R L + L + E L+ + L KE L E+ L+ IA + E KEL
Sbjct: 1554 EMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQK 1613
Query: 971 QKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLAR 1030
+ + + S +R H ++ +++EK+ + +L + A ++E E+ L
Sbjct: 1614 EYEILLQSYENVSNEAERIQHV--VEAVRQEKQELYGKLRSTEAN-----KKETEKQLQE 1666
Query: 1031 LEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISL 1090
E E EE+ E++ + + + +L E E + + E + S A++
Sbjct: 1667 AEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKE 1726
Query: 1091 EMERQKRDAQSRQEQDRSTVN---ALTSELRDLRAQRE---------EAAAAHAQEVRRL 1138
E+ER K + ++ ++ +S ++ +L+ E++DL+ Q E EA H +
Sbjct: 1727 ELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVT 1786
Query: 1139 QEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEA 1198
+E + + + + E + L R + A K S + Q+
Sbjct: 1787 EEGTQSIPGETE----EQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQI 1842
Query: 1199 GELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVG 1258
+L+ + +E++ + ++ L E+E+ +L K+ +L +L+E T +
Sbjct: 1843 DQLKERIAGLEEEKQKNKEFSQTL-------ENEKNTLLSQISTKDGELKMLQEEVTKMN 1895
Query: 1259 KEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEK 1318
+++ L V + + A E +L RL +LAEL G ++G +
Sbjct: 1896 LLNQQIQEELSRVTKLKETAEEEKDDLEE----------RLMNQLAELNG--SIGNYCQD 1943
Query: 1319 ESRRETLGLRQRLLKGEA-SLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTE 1377
+ + ++ LL+ E +L+ EL+ +++L +++ + + R+ LE+ +G +
Sbjct: 1944 VTDAQ---IKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEY--LEKIQGAQ 1998
Query: 1378 KQ--QLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGG 1435
K+ HA+ L+ L+ + E +L + + LE + +E + ++ L
Sbjct: 1999 KEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEI 2058
Query: 1436 LRSALRRGLGLGRAPSP--APRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGP 1493
+ L + + + A V + A + L L+ S S
Sbjct: 2059 TKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQ----SNKESVKS 2114
Query: 1494 ATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRA 1553
DL+ + A + L+E ++ Q + D LR + L + E++ +
Sbjct: 2115 QMKQKDEDLE-RRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEV 2173
Query: 1554 RQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATE 1613
+QLQ+ + + + +S +Q + ++ + +++ R D + + E ++ E
Sbjct: 2174 QQLQENLDSTVTQLAAFTKSMSSLQDD---RDRVIDEAKKWERKFSDAIQSKEEEIRLKE 2230
Query: 1614 SELRASQEKISKMKANETKLEGDKRRLKEVLDASESRT-VKLELQRR---SLEGELQRSR 1669
++++ +M + +L+ + RL+ ES+ +++LQ++ +L+GE +
Sbjct: 2231 DNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENK--- 2287
Query: 1670 LGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVR 1729
+ +Q + + S Q ++A E + +L+ + L+ +L K +E +G L +R
Sbjct: 2288 ----ELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIR 2343
Query: 1730 GLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGE 1789
EA Q+S + +L + LT+ H+ ++E +K S L
Sbjct: 2344 -QQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKE------------QKIISLLSG 2390
Query: 1790 QVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGS 1849
+ + ++ +A+L R + + ++++L +L Q +E +K D+ L E L +
Sbjct: 2391 KEEAIQVAIAEL---RQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKT 2447
Query: 1850 LQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRL----SAEKGR 1905
+++ Q +A+ +S L+ DR + ++E L + +L +AE +
Sbjct: 2448 IKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNK 2507
Query: 1906 LDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL---ELQQEVERLR 1962
L + G + + + +L+A+++ + + D+QQ+QL +LQQ E L
Sbjct: 2508 LKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKE-LE 2566
Query: 1963 SAQAQTERTLEARERAH----------RQRVRGLEEQVSTLKGQLQQELRRSSA 2006
+ A+ E L+ E A+ ++ + L +++ +LK + Q R+ +A
Sbjct: 2567 NKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTA 2620
Score = 211 bits (536), Expect = 8e-54
Identities = 411/2063 (19%), Positives = 839/2063 (40%), Gaps = 251/2063 (12%)
Query: 44 ITSLPALIREIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAE 103
+TS I + + +S+ E + ++ L+ +E+ Q L +++++ Q +
Sbjct: 1051 VTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT----LQDKTN 1106
Query: 104 RDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQ 163
+ +L + ++ + Q L + + LV+++V + ++ +L+
Sbjct: 1107 QIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKI 1166
Query: 164 EGQQRQA-QLVQRLQGKILQYK---KRCSELEQQLLERSGELEQQRLRDTEHSQDLESAL 219
+++ QL ++LQ + K K+ E E+ L E EL+QQ+ ++++ E
Sbjct: 1167 LALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLRE---ELKQQK---DDYNRLQEQFD 1220
Query: 220 IRLEEEQQRSASLAQVNAMLREQLD---------QAGSANQALSEDIRKVTNDWTRCRKE 270
+ +E + L Q+ +RE +D ++ S+ L E + K T +
Sbjct: 1221 EQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQH-HTQPV 1279
Query: 271 LEHREAA-WRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMF-TERDLLQLGGEL 328
LE W E +A + + + ++ E+K+ T +L + E+
Sbjct: 1280 LESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEV 1339
Query: 329 ARTSRAVQEAGL---GLSTGLRLAESRAEAALEKQALLQAQLE--EQLRDKVLREKDLAQ 383
+ + + GL L T AE AE+ +K Q Q+ E LR+ + +L +
Sbjct: 1340 FQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQK 1399
Query: 384 QQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEA-------------L 430
+ + D + LS +++E A+ +++ + +E++ + K L +LE +
Sbjct: 1400 LISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQV 1459
Query: 431 ESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQ 490
E ++++ E+ QQ R L A++S E+ + + + G++ L+
Sbjct: 1460 ELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKS 1519
Query: 491 RTPSPPRRSSPGRGRSPRRGPSPACS---DSSTLALIHSALHKRQLQVQ------DMRGR 541
+ S+ + + G D + S L + L + G
Sbjct: 1520 LADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGL 1579
Query: 542 YEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELL 601
E + L+ + S +E +E+ + L+ + + +Q++E+ E +R++ E +
Sbjct: 1580 TEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAV 1639
Query: 602 SREKSNL--------------AHSLQVAQQQAEELRQEREKLQAAQE----ELRRQRDRL 643
+EK L LQ A+Q+ EE++++ K +++ EL + DRL
Sbjct: 1640 RQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRL 1699
Query: 644 EEE-----------QEDAVQDGARVRRELERSHRQLEQLEGK-------RSVLAKELVEV 685
E E + A ++ ELER + E L K + L++E+ ++
Sbjct: 1700 RAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDL 1759
Query: 686 REALS-----RATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSK 740
+ + +A L+ + V E T++ G E + S++ + + +S+
Sbjct: 1760 KHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSM--STRPTCSESVPS 1817
Query: 741 LSALNESLAQDKL---DLNRLVAQLEEEKSALQG----RQRQAEQEATVAREEQERLEEL 793
+ N ++++D ++N + Q+++ K + G +Q+ E T+ E+ L ++
Sbjct: 1818 AKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQI 1877
Query: 794 R--------LEQEVARQGLEGSLRVAEQAQEALEQQLP---TLRHERSQLQEQLAQLSRQ 842
L++EV + L + +Q QE L + T E+ L+E+L +
Sbjct: 1878 STKDGELKMLQEEVTKMNL-----LNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAE 1932
Query: 843 LSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRL 902
L+G Q +AQ + E LE + + E E E + L +E T++
Sbjct: 1933 LNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSE----------LEEEKQQLVKEKTKV 1982
Query: 903 RLE--KEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQE 960
E KE LE + Q AQ E + E Q LL K+ E+ L++ I QE
Sbjct: 1983 ESEIRKEYLE------KIQGAQKEPGNKSHAKELQELLKEKQQ---EVKQLQKDCIRYQE 2033
Query: 961 KAS-LDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQ 1019
K S L++ + A + VQ E + + ++ A + ++ + + A+++ L + ++
Sbjct: 2034 KISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAAR 2093
Query: 1020 LQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLM 1079
+ + +L L++ KE + ++ ++ + L AE + + + + AL + +
Sbjct: 2094 VLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKV 2153
Query: 1080 GTRHSLATISLEMERQKRDAQSRQEQDRSTVN---ALTSELRDLRAQREEAAAAHAQEVR 1136
++ I + + ++ ++ Q QE STV A T + L+ R+ + R
Sbjct: 2154 HLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWER 2213
Query: 1137 R----LQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGRE 1192
+ +Q + ++ + D+C ++LR +E+ + + R LE +++ ES+ E
Sbjct: 2214 KFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISR--LEHDKQIWESKAQTE 2271
Query: 1193 VQRQEA------GELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQK 1246
VQ Q+ GE + L + + R S EL K ESE SLK D
Sbjct: 2272 VQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELA----KLESELKSLKDQLTDLSNS 2327
Query: 1247 LALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAEL 1306
LE+ + G G +R +++ S+ + +L+ ++ + + + ++
Sbjct: 2328 ---LEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKI 2384
Query: 1307 QGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRL 1366
L+ E A + + E LRQ+ K LE + + + L+E+ + + +L
Sbjct: 2385 ISLLSGKEEAIQVAIAE---LRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQL 2441
Query: 1367 LGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQR 1426
+ +L+ + QQ + + + + + E R + E ++ +Q
Sbjct: 2442 METLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQL-IQE 2500
Query: 1427 RAAE-----AQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLE 1481
AAE ++ GLRS + L A DA E LN T++
Sbjct: 2501 AAAENNKLKEEIRGLRSHM-DDLNSENA------------KLDAELIQYREDLNQVITIK 2547
Query: 1482 CSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAE 1541
SQ + +L+ + + ++L+ ++ ++LR +AL + +
Sbjct: 2548 ---DSQQKQLLEVQLQQNKELENKYAK-----LEEKLKESEEANEDLRRSFNALQEEKQD 2599
Query: 1542 MEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQ 1601
+ E +S QL + V +E +G L A+L ++EE V R ++ +
Sbjct: 2600 LSKEIESLKVSISQLTRQVTALQE-----EGTLGLYHAQLKVKEEEVHRLSALFSSSQKR 2654
Query: 1602 VATLERSLQATESELRASQEKI-SKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRS 1660
+A LE L + E +I K+K L D ++ + +E R +L
Sbjct: 2655 IAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVE 2714
Query: 1661 LEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEES 1720
+E +L AQ Q+ + SLQ + + L+ + LA+++E
Sbjct: 2715 MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKE- 2773
Query: 1721 EGALRDKVRGLTEALAQSSASLNSTRDKNL-HLQKALTACEHDRQVLQERLDAARQALSE 1779
+G L R L++++ S+NST + +L HL+K L ++L + + L
Sbjct: 2774 QGLLN---RERDALLSETAFSMNSTEENSLSHLEK-----------LNQQLLSKDEQLLH 2819
Query: 1780 ARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEA------AALNTV 1833
Q QVQ+ +A L+ +R +L++ R+ +Q A A + ++
Sbjct: 2820 LSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSL 2879
Query: 1834 QK----LQDERRLLQERLGSLQRALAQLEAEKREVE--RSALRLEKDRV-ALRRTLDKVE 1886
+K LQ++R L + L +LQ+ Q+ E E+ ++ L+ +D+ A + +++
Sbjct: 2880 KKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELR 2939
Query: 1887 REKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVD 1946
+E L + +L EK + E+ E + + Q L A D
Sbjct: 2940 QENLSWQHELHQLRMEK---------SSWEIHERRMKEQYLMA--------------ISD 2976
Query: 1947 AQQQQLELQQEVERLRSAQAQTE 1969
QQ LQ + LRS+ +QT+
Sbjct: 2977 KDQQLSHLQNLIRELRSSSSQTQ 2999
Score = 204 bits (519), Expect = 7e-52
Identities = 447/2265 (19%), Positives = 907/2265 (40%), Gaps = 346/2265 (15%)
Query: 5 LARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQD-----------AQITSLPALIRE 53
LA A+++ + L+ +I+ + + +++ L A D A++TSL I E
Sbjct: 54 LAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEE 113
Query: 54 IVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNA 113
+ + + +LP TE S L + ++ +E +E + + + E++EL +
Sbjct: 114 M------KAQGGTVLP-TEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQ-EKEELI---ST 162
Query: 114 VSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLV 173
+ +L QA +P + T+ + + V +++QLQE++ + LQA Q +
Sbjct: 163 LQAQLTQAQAEQPAQSSTE-----MEEFVMMKQQLQEKE-EFISTLQAQLSQTQAEQAAQ 216
Query: 174 QRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLA 233
Q ++ K +++ + E +LL+ L Q +TE Q L +LEE ++ A
Sbjct: 217 QVVREKDARFETQVRLHEDELLQ----LVTQADVETEMQQKLRVLQRKLEEHEESLVGRA 272
Query: 234 QVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKE-----------LEHREAAWRREE 282
QV +L+++L A NQ LS+ ++++ + R LE E +
Sbjct: 273 QVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERK 332
Query: 283 ESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGE------LARTSRAVQ 336
SF+ H L + L S ++ ++ + L +T + +Q
Sbjct: 333 LSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQ 392
Query: 337 EAGLGL-STGLRLAESRAEAALEKQALLQAQLEEQLRDK-----------VLREKDLAQQ 384
A L +L + + E A++ +Q QLE+QL+ K L++ + A Q
Sbjct: 393 SACDALKDQNSKLLQDKNEQAVQSAQTIQ-QLEDQLQQKSKEISQFLNRLPLQQHETASQ 451
Query: 385 -----------QMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL 433
Q ++ + A L RV EL L ++E +++ + EKL + +L
Sbjct: 452 TSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAE-NEKLSSQITL 510
Query: 434 RLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTP 493
L+ Q D E + ++ D+A S +E SG + + + + LS
Sbjct: 511 -LEAQNRTGEADREVSEISIVDIANKRSSSAEE----SGQDVLENTFSQKHKELSVLLLE 565
Query: 494 SPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRG---------RYEA 544
+ + +G +D H L +++++ + G +
Sbjct: 566 MKEAQEEIAFLKLQLQGKRAEEAD-------HEVLDQKEMKQMEGEGIAPIKMKVFLEDT 618
Query: 545 SQDL---------LGTLRKQLSDSESERRALEE--------QLQRLRDKTDGAMQAHEDA 587
QD L + K+ + +E + R EE +L+ + D ++ A D
Sbjct: 619 GQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDI 678
Query: 588 ----QREVQRLRS-----------ANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAA 632
Q E++RL+S A E+ + A + Q EE ++ + +A
Sbjct: 679 GQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSA 738
Query: 633 QEELRRQRDRL----------------EEEQEDAVQDGARVRR---ELERSHRQL--EQL 671
L +RD+L ++ E + + R RR E + +H L EQ+
Sbjct: 739 FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQI 798
Query: 672 EG----------KRSVLAKELVEVREALS-RATLQRDM---LQAEKAEVAEALTKAE--A 715
K VL EL +V+ S ++TL R + LQ +++EV E + +
Sbjct: 799 HSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHIS 858
Query: 716 GRVE--------LELSMTK----LRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLE 763
+VE EL +TK L ++ ++ + ++ + + + + QL
Sbjct: 859 SKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLN 918
Query: 764 EEKSALQGR-QRQAEQEATVAREEQERLEELRLEQEVA---RQGLEGSLRVAEQAQEALE 819
EEK +L + EQ ++R E+ + E++ + EV+ +Q + + ++E L+
Sbjct: 919 EEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ 978
Query: 820 QQLPTLRHERSQLQEQL-------AQLSRQLSGREQELEQARREAQRQV--EALERAARE 870
+ L+ E Q + +L +L +++S E+EL + E+++++ ER E
Sbjct: 979 HEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVE 1038
Query: 871 KEALAKEHAGLAVQLVAAERE---GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARR 927
++ KE++ V E E +T+SE+ L+ ++ LE L ++ A ++
Sbjct: 1039 EDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMN 1098
Query: 928 EQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQ 987
+ L+ + + L + ++ A +++ I + + + D + ++ V S
Sbjct: 1099 QTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHW 1158
Query: 988 RAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQ 1047
+ EE + L++EKE ++L+ ++ L++ QE+ L E ++ ++ LQ+
Sbjct: 1159 KPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEK-ERHLREELKQQKDDYNRLQE 1217
Query: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGT---RHSLATISLEMERQKRDAQSRQE 1104
+ DE E+ Q L+ + ++ KL T +T LE K Q +
Sbjct: 1218 QFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQ 1277
Query: 1105 ---------------------QDRSTVNALTSELRDLRAQREE---AAAAHAQEVRRLQE 1140
Q ++V + ++L+++ A++ E ++ E+ + E
Sbjct: 1278 PVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSE 1337
Query: 1141 QARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGE 1200
+ L +Q + E E L+T E + L+++L +Q ++ + RE+Q + E
Sbjct: 1338 EVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQ-PKLDE 1396
Query: 1201 LRRSLGEGAKEREALRRSNEELRSAVKKAESERI-----------SLKLANEDKEQKLAL 1249
L++ + + ++ L E +A+ K ++E I L++ ++ ++++
Sbjct: 1397 LQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQ 1456
Query: 1250 LEEARTAV---GKEAGELRTGLQEVER-------SRLEARRELQELRRQMKMLDSENTRL 1299
L+ + +E GE Q+++R SR EA +E + L+ ++ + RL
Sbjct: 1457 LQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERL 1516
Query: 1300 GRELAELQGRLALGERAE----------KESRRETLGLRQRLLKGEASLEVMRQELQVAQ 1349
+ LA+++ +++ + + +E R + + R L SL + L++A
Sbjct: 1517 TKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLAL 1576
Query: 1350 RKLQEQEGEFRTRERRLLGSLEEARGTEKQQ-------------------LDHARGLELK 1390
L E + E +E L S + A TE Q+ + A ++
Sbjct: 1577 EGLTEDK-EKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHV 1635
Query: 1391 LEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAP 1450
+EA R E EL G+ + EA E Q + AE ++ ++ +R+ A
Sbjct: 1636 VEAVRQEKQEL-------YGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRK-----FAK 1683
Query: 1451 SPAPRPVPGSPARD-APAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRG 1509
S + + D AE G + +E +S AS + E V+
Sbjct: 1684 SKQQKILELEEENDRLRAEVHPAGDTAKECMETL----------LSSNASMKEELERVKM 1733
Query: 1510 ALREFLQELRSAQRERDELRTQTSALNRQL-------AEMEA--ERDSATSRARQLQKAV 1560
++ +S E+D L + L Q+ A +EA + D+ T+ + +++
Sbjct: 1734 EYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSI 1793
Query: 1561 AESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQ 1620
E + S+ +E +S + + ++ D++ + + + + +
Sbjct: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE 1853
Query: 1621 EKISKMKANETKLEGDKRRLKEVLDAS-------ESRTVKLELQRRSLEGELQRSRLGLS 1673
E+ K K LE +K L + + K+ L + ++ EL R
Sbjct: 1854 EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKE 1913
Query: 1674 DREAQAQALQDR-----------VDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEG 1722
E + L++R + + + V D+++K L+ ++ L ++++EE
Sbjct: 1914 TAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE--- 1970
Query: 1723 ALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARK 1782
+K + + E S +K QK H ++ LQE L +Q + + +K
Sbjct: 1971 ---EKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKE-LQELLKEKQQEVKQLQK 2026
Query: 1783 QSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQ----RQEGEAAALNTVQKLQD 1838
E++ L V LE + E++ L+ +E L Q R++ +A + L D
Sbjct: 2027 DCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDD 2086
Query: 1839 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVE----REKLRSHE 1894
+ L + +L++ K V+ + ++D L R L++ E +EK E
Sbjct: 2087 TQSEAARVLADNLKLKKELQSNKESVKSQMKQKDED---LERRLEQAEEKHLKEKKNMQE 2143
Query: 1895 DTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL 1954
L EK L+ T+ ++ L + +++QQL+ E S + L
Sbjct: 2144 KLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQ------ENLDSTVTQLAAFTKSMSSL 2197
Query: 1955 QQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQ 1999
Q + +R+ + ER ++ + +R E+ S LK QL+Q
Sbjct: 2198 QDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQ 2242
Score = 197 bits (500), Expect = 1e-49
Identities = 449/2130 (21%), Positives = 848/2130 (39%), Gaps = 286/2130 (13%)
Query: 40 QDAQITSLPALIRE----IVTRNLSQPESPVLLPATEMASLL-------SLQEENQLLQQ 88
+ A TS P + E + N++ + V+ E +LL L+ EN+ L
Sbjct: 447 ETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSS 506
Query: 89 ELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQL 148
+++ +E A+R+ I ++ + R E Q+ L
Sbjct: 507 QITLLEAQNRTGEADREVSEISIVDIANK-----RSSSAEESGQDV---------LENTF 552
Query: 149 QEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQR--- 205
++ L +E Q+ A L +LQGK R E + ++L++ E++Q
Sbjct: 553 SQKHKELSVLLLEMKEAQEEIAFLKLQLQGK------RAEEADHEVLDQK-EMKQMEGEG 605
Query: 206 ---------LRDTEHSQDL----ESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQA 252
L DT L ES+L +E+EQ + ++ + + L+ AG ++
Sbjct: 606 IAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEI--SLNDAGVELKS 663
Query: 253 LSEDIRKVTN---DWTRCRK-ELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRR 308
+D K + D +C + ELE ++ E +F+ L +++ +
Sbjct: 664 TKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQ 723
Query: 309 LVSEVKM--------FT----ERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAA 356
L+ E K FT ERD QL ++ S + + LAE+ +
Sbjct: 724 LIEEFKKNADNNSSAFTALSEERD--QLLSQVKELSMVTELRAQVKQLEMNLAEAERQRR 781
Query: 357 L--EKQALLQAQLEEQLRDKVL--REKDLAQQQMQSDLDKADL-----SARVTELGLAVK 407
L E Q L EQ+ + + KD+ + +Q++LD L S + L ++
Sbjct: 782 LDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQ 841
Query: 408 RLEKQNLEKDQVNKDLTEKLEALESLRLQEQAAL---------ETEDGEGLQQTLRDLAQ 458
E + LE + + ++ K+E L Q++ + + D E LQQT+ + Q
Sbjct: 842 NKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQ 901
Query: 459 AV----LSDSESGVQLSGSERTADASNGSLRG-LSGQRTPSPPRRSSPGRGRSPRRGPSP 513
V S +E VQL+ + + +L+ L+ ++ G
Sbjct: 902 QVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQ 961
Query: 514 ACSDSSTLALI--HSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQ 571
+ S I H+ L ++ R Q L RK+L S LEE+L
Sbjct: 962 NYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALIN-RKELLQRVSR---LEEELA 1017
Query: 572 RLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQA--------EELR 623
L+D++ + E + EV+ + E + ++ +++ +Q + +R
Sbjct: 1018 NLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIR 1077
Query: 624 QEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQL--------EGKR 675
++ E+ AA+E+ + ++ + +D ++ E+ + +++L +G
Sbjct: 1078 KDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDS 1137
Query: 676 SVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTK-LRAEEASL 734
L KE V + + ++ + K E+ E + E + +L+ + + L + +A L
Sbjct: 1138 VALVKETVVISPPCTGSS------EHWKPELEEKILALEKEKEQLQKKLQEALTSRKAIL 1191
Query: 735 QDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELR 794
+ + K L E L Q K D NRL Q +E+ + Q Q RE +
Sbjct: 1192 KKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPST 1251
Query: 795 LEQEVARQ--GLEGSL-RVAEQ--AQEALEQQL----PTLRHERSQLQ--EQLAQLSRQL 843
+QE GLE L + EQ Q LE L P+ + S LQ +AQ+ QL
Sbjct: 1252 DQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQL 1311
Query: 844 SGREQELEQARREAQRQVEALERAAREKEALAKE--HAGLAVQLVAAEREGRTLSEEATR 901
E E + + L + + E L ++ GL ++ + +T+S EA
Sbjct: 1312 KEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESL------KTVSHEA-- 1363
Query: 902 LRLEKEALEGSLFEVQRQLAQLEARREQLEA--EGQALLLAKETLTGELAGLRQQIIATQ 959
+ E+L+ L Q Q+A LE RE E Q L+ KE L+G + A
Sbjct: 1364 -EVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAAL 1422
Query: 960 EKASLDKELMAQK-LVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELE--AERAQL 1016
K + E++ Q+ L++A L Q H+E +++LQ E ++ E E ++
Sbjct: 1423 TK--IQTEIIEQEDLIKA---LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477
Query: 1017 QSQLQRE-QEELLARLEAEKEELS-EEIAALQQERDEGLLLAESEKQQALSLKESEKTAL 1074
+ Q+QR+ Q L++R EA KE S +E +L + E L + ++ + +S + EK +
Sbjct: 1478 KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537
Query: 1075 SEKLMGTRHSLATISLEMERQKRDAQSRQEQDRS---TVNALTSELRDLRAQREEAAAAH 1131
+L + + EM+R + QS S + LT + L + E ++
Sbjct: 1538 LGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK 1597
Query: 1132 AQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR 1191
E QE+ ++L K+ + L+ E + + ++ + +R+E E KLR ++ +
Sbjct: 1598 IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1657
Query: 1192 ---EVQRQEAG----ELRRSLGEGAKEREA----LRRSNEELRSAVK------------- 1227
E Q QEA E++ + + AK ++ L N+ LR+ V
Sbjct: 1658 KETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETL 1717
Query: 1228 -------KAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARR 1280
K E ER+ K+ E +K L + ++ +E +L+ ++ +A
Sbjct: 1718 LSSNASMKEELERV--KMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEG--NVSKQANL 1773
Query: 1281 ELQELRRQMKMLDSENTRLGRELAELQGRLALGERAE-KESRRETLGLRQRLLKGEASLE 1339
E E + E T+ E Q L++ R ES + K +S +
Sbjct: 1774 EATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHD 1833
Query: 1340 VMRQELQVAQRKLQEQEG--EFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAE 1397
+ LQ + + G E + + + +LE + T Q+ G +L+ + E
Sbjct: 1834 EINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDG---ELKMLQEE 1890
Query: 1398 AAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLG-LGRAPSPAPRP 1456
++ L Q ++ EL+RV + AE + L L L L + +
Sbjct: 1891 VTKMNLL-------NQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQD 1943
Query: 1457 VPGSPARDAPAEGSGEGLNS-PSTLECSPGSQPPSPGPATSPASPDLDPEAVRGA----- 1510
V + ++ E + L S LE S + E ++GA
Sbjct: 1944 VTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEY-LEKIQGAQKEPG 2002
Query: 1511 -----------LREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKA 1559
L+E QE++ Q++ + + SAL R + +E + + ++
Sbjct: 2003 NKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKEN 2062
Query: 1560 VAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRAS 1619
+A++ E R+ L+ + L +++ + R L L+ + ++ +S+++
Sbjct: 2063 LAQAVEHRKKAQAELASFKV---LLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQK 2119
Query: 1620 QEKISK-MKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQ 1678
E + + ++ E K +K+ ++E LDA V LE GE+Q + L+ ++ +
Sbjct: 2120 DEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLE----ETIGEIQ---VTLNKKDKE 2172
Query: 1679 AQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEES-EGALRDKVRGLTEALAQ 1737
Q LQ+ +DS Q+A +LQ +R+ K E A++ K +
Sbjct: 2173 VQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDN 2232
Query: 1738 SSASLNSTRDKNLHLQKA---LTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTL 1794
S + R ++H+++ ++ EHD+Q+ + + A +E + Q + TL
Sbjct: 2233 CSVLKDQLRQMSIHMEELKINISRLEHDKQIWESK------AQTEVQLQQ----KVCDTL 2282
Query: 1795 RGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRAL 1854
+GE E QL++ R + Q N + KL+ E + L+++L L +L
Sbjct: 2283 QGE-------NKELLSQLEETRHLYHSSQ-------NELAKLESELKSLKDQLTDLSNSL 2328
Query: 1855 AQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAE----KGRLDRTL 1910
+ + +K +E + E D + + +++E + S E T RL E + ++ L
Sbjct: 2329 EKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLL 2388
Query: 1911 TGAE---------------LELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQ 1955
+G E E+ E + + Q E + +VLE+ + A VD Q +E
Sbjct: 2389 SGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKA---VDKTNQLMETL 2445
Query: 1956 QEVERLRSAQ-AQTERTLEARERAHRQRVR 1984
+ +++ Q AQ + +++ R R
Sbjct: 2446 KTIKKENIQQKAQLDSFVKSMSSLQNDRDR 2475
Score = 194 bits (494), Expect = 6e-49
Identities = 464/2247 (20%), Positives = 896/2247 (39%), Gaps = 412/2247 (18%)
Query: 5 LARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNL--SQP 62
LA ++ + ++ + QTL+ DL Q A+I+ A+I++++T N S
Sbjct: 1084 LAAEEQFQALVKQMNQTLQDKT-------NQIDLLQ-AEISENQAIIQKLITSNTDASDG 1135
Query: 63 ESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQAL 122
+S L+ T + S ++ + EL E +LA + E+++L ++L++AL
Sbjct: 1136 DSVALVKETVVISP-PCTGSSEHWKPELE--EKILALEK-EKEQL-------QKKLQEAL 1184
Query: 123 RLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEG-----------QQRQAQ 171
L+ + + LR +L++++ Y R + + E +Q Q Q
Sbjct: 1185 TSRKAILKKAQEK-----ERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQ 1239
Query: 172 LVQRLQGKI--LQYKKRCSE---LEQQLLERSGELEQQRLRDTE-------HSQDLESAL 219
+ + + GK+ ++ CS LE+ L + + + Q + ++ HS+D SAL
Sbjct: 1240 VRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDA-SAL 1298
Query: 220 IRLEEEQQRSASLAQVNAMLRE----------QLDQAGSANQALSEDIRKVTNDWTRCRK 269
Q S+AQ+ A L+E ++ S SE++ ++ +
Sbjct: 1299 -------QGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGL 1351
Query: 270 ELE-----------HREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTE 318
E+E H E+ ++ E S EH R L ++ ++L+S+ E
Sbjct: 1352 EIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQ--PKLDELQKLISK----KE 1405
Query: 319 RDLLQLGGELARTSRA--------VQEAGLGLSTGLRLAESRAEAALEKQALLQAQL-EE 369
D+ L G+L+ A +++ L + +L E +A+ E+ LQ +L E
Sbjct: 1406 EDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQL-EMQAKEHDERIKQLQVELCEM 1464
Query: 370 QLRDKVLREKDLAQQQMQSDLDKADLSARVT---------ELGLA---VKRLEK------ 411
+ + + + E+ A+QQ+Q L A +S + EL LA ++RL K
Sbjct: 1465 KQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVE 1524
Query: 412 -----QNLEKDQVNKDLTEKLEALESLRLQ-EQAALETEDGEGLQQTLRDLAQAVLSDSE 465
QN EKD V L E + L + +++ LE + ++L+ + + D E
Sbjct: 1525 SQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKE 1584
Query: 466 S---GVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLA 522
++ S + A+++ + Q+ +S R
Sbjct: 1585 KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAER------------- 1631
Query: 523 LIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRL-RDKTDGAM 581
I + + + Q++ G+ +++ KQL ++E E ++E++++ + K +
Sbjct: 1632 -IQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKIL 1690
Query: 582 QAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRD 641
+ E+ R + A + L S +++ E ++ E E L + L ++D
Sbjct: 1691 ELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKD 1750
Query: 642 RLEEEQEDA---VQDGARVRRELERSHRQLEQL----EGKRSVLAKELVEVREALS---R 691
L EE +D ++ + LE + + Q EG +S+ + E +++LS R
Sbjct: 1751 SLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGE--TEEQDSLSMSTR 1808
Query: 692 ATLQRDMLQAEKAEVAEALTKAEAGRVELELS-MTKLRAEEASLQDSLSKLSALNESLAQ 750
T + A+ A A + + + L + +L+ A L++ K +++L
Sbjct: 1809 PTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLEN 1868
Query: 751 DKLDLNRLVAQ----------LEEEKSALQGRQRQAEQEAT-------VAREEQERLEEL 793
+K N L++Q L+EE + + +Q ++E + A EE++ LEE
Sbjct: 1869 EK---NTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEER 1925
Query: 794 RLEQEVARQGLEGS----LRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQE 849
+ Q G G+ + A+ E LE ++ L+ S+L+E+ QL ++ + E E
Sbjct: 1926 LMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESE 1985
Query: 850 LEQARREAQRQVEALERA------AREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLR 903
+ R+E +++ ++ A+E + L KE QL +++ E+ + L
Sbjct: 1986 I---RKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQL---QKDCIRYQEKISALE 2039
Query: 904 LEKEALEGSLFEVQRQL-------AQLEARREQLEAEGQALLLAKETLTGELAGLRQQII 956
+ALE E Q+ L AQ R++ +AE + + + E A + +
Sbjct: 2040 RTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNL 2099
Query: 957 ATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRE---LEAER 1013
+++ +KE + ++ Q + + + L + H ++ + +Q + +A RE LE
Sbjct: 2100 KLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETI 2159
Query: 1014 AQLQSQLQREQEE---LLARLEAEKEELS---EEIAALQQERDEGLLLAES--------- 1058
++Q L ++ +E L L++ +L+ + +++LQ +RD + A+
Sbjct: 2160 GEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAI 2219
Query: 1059 -EKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRD-------AQSRQEQDRSTV 1110
K++ + LKE + L ++L + + + + R + D AQ+ + +
Sbjct: 2220 QSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVC 2279
Query: 1111 NALTSELRDLRAQREEAA----------AAHAQEVRRLQEQARDLGKQRDSCLREA---- 1156
+ L E ++L +Q EE A E++ L++Q DL + C +
Sbjct: 2280 DTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLE 2339
Query: 1157 -----------------EELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEA- 1198
E+L T L+ + L E+ ++K+ G+E Q A
Sbjct: 2340 GIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAI 2399
Query: 1199 GELRRSLGEGAKEREALRRSNEEL--------RSAVKKAESERISLK-LANEDKEQKLAL 1249
ELR+ + KE E L EE + AV K +LK + E+ +QK L
Sbjct: 2400 AELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQL 2459
Query: 1250 -----------------------LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELR 1286
LEE ++ E +L +QE + + E++ LR
Sbjct: 2460 DSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQL---IQEAAAENNKLKEEIRGLR 2516
Query: 1287 RQMKMLDSENTRLGRELAE----LQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMR 1342
M L+SEN +L EL + L + + + +K+ L + L A LE
Sbjct: 2517 SHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKL 2576
Query: 1343 QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLE---------LKLEA 1393
+E + A L+ + ++ L +E + + Q L+ +L+
Sbjct: 2577 KESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKV 2636
Query: 1394 ARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGL-------GL 1446
E L S+++ R LE EL V VQ+ AA+ ++G + L++ L G+
Sbjct: 2637 KEEEVHRLSALFSSSQKRIAELEEEL--VCVQKEAAK-KVGEIEDKLKKELKHLHHDAGI 2693
Query: 1447 GRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEA 1506
R + ARD
Sbjct: 2694 MRNETETAEERVAELARD------------------------------------------ 2711
Query: 1507 VRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEA 1566
L E Q+L +E L Q + R ++ ++ RD A E +E
Sbjct: 2712 ----LVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANE----------ELDEL 2757
Query: 1567 RRSVDGRLSGVQAELA-LQEESVRRSERERRATLDQVA-----TLERSLQATES---ELR 1617
+R D L ELA L+E+ + RER A L + A T E SL E +L
Sbjct: 2758 KRKYDASLK----ELAQLKEQGLLN--RERDALLSETAFSMNSTEENSLSHLEKLNQQLL 2811
Query: 1618 ASQEKI----SKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLS 1673
+ E++ S+++ + +++ + + + + + +LE R+S EG+ QRS S
Sbjct: 2812 SKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGK-QRSAAQPS 2870
Query: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR---DKVRG 1730
A+ Q+L+ + SLQ + LQ ++N + ++ + L+ DK +
Sbjct: 2871 TSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKA 2930
Query: 1731 LTEALAQSSASLNSTRDKNLH-LQKALTACE-HDRQVLQERLDAARQALSEARKQSSSLG 1788
+ + + N + LH L+ ++ E H+R++ ++ L A+S+ +Q S L
Sbjct: 2931 F-QIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYL----MAISDKDQQLSHLQ 2985
Query: 1789 EQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLG 1848
++ LR + + +V+ + RQ +A+ + Q L E LL+ +L
Sbjct: 2986 NLIRELRSSSSQTQPLKVQYQ----------RQASPETSASPDGSQNLVYETELLRTQLN 3035
Query: 1849 SLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVE---REKLRSHEDTVRLSAEKGR 1905
+ + Q E +++ + +L +++ L L RE + + D + A +
Sbjct: 3036 DSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEK 3095
Query: 1906 LDRTLTGAELELAEAQRQIQQLEA--QVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRS 1963
+ L L + A Q+ + E+ P Q +AQQQ +QEV LR
Sbjct: 3096 QVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRK 3155
Query: 1964 AQAQTERTLEARERA---HRQRVRGLE 1987
+ A E A +++R LE
Sbjct: 3156 LLEEERDQRVAAENALSVAEEQIRRLE 3182
Score = 176 bits (447), Expect = 2e-43
Identities = 390/1916 (20%), Positives = 757/1916 (39%), Gaps = 235/1916 (12%)
Query: 208 DTEHSQDLESALIRLEEEQQRSASLAQV----NAMLREQLDQAGSANQALSEDIRKVTND 263
+ D+E E+ Q+R A Q+ ++R++ Q ++AL E+ + N
Sbjct: 33 ELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADN- 91
Query: 264 WTRCRKELEHREAAWRREEESFNAYFSNEHSRL-LLLWRQVVGFRRLVSEVKMFTERDLL 322
+ +K H +A + S N Y ++ +L + +L K TE ++
Sbjct: 92 --KIKKLKLHAKA----KLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEM- 144
Query: 323 QLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKV-LREKDL 381
E+ + +QE +ST L +A E+ A ++EE + K L+EK+
Sbjct: 145 ----EIEKIKHKLQEKEELIST---LQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEE 197
Query: 382 AQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAAL 441
+Q+ L + ++ +Q + + + +L E L+L QA +
Sbjct: 198 FISTLQAQLSQTQ-----------AEQAAQQVVREKDARFETQVRLHEDELLQLVTQADV 246
Query: 442 ETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSP 501
ETE +QQ LR L + + ES L G + D L + +
Sbjct: 247 ETE----MQQKLRVLQRKLEEHEES---LVGRAQVVDLLQQELTAAEQRNQILSQQLQQM 299
Query: 502 GRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSES 561
+ R + S + L K +L+V + + + Q+ + L +Q +
Sbjct: 300 EAEHNTLRNTVETEREESKILL-----EKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQ 354
Query: 562 ERRALEEQLQRLRDKTDGAMQAHED----AQREVQRLRSANELLSREKSNLAHSL-QVAQ 616
+ LE + L K M+ Q+ Q L+SA + L + S L + A
Sbjct: 355 AQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAV 414
Query: 617 QQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRS 676
Q A+ ++Q ++LQ +E+ + +RL +Q + + E + E+
Sbjct: 415 QSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQ 474
Query: 677 VLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEA----GRVELELSMTKLRAEEA 732
EL + AL ++++ + L+AE +++ +T EA G + E+S E
Sbjct: 475 KRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVS-------EI 527
Query: 733 SLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAR-----EEQ 787
S+ D +K S+ E QD L+ +Q +E S L ++A++E + +
Sbjct: 528 SIVDIANKRSSSAEESGQDVLE--NTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRA 585
Query: 788 ERLEELRLEQEVARQGLEGSLRVAEQAQEALE---QQLPTLRHERSQL----QEQLAQLS 840
E + L+Q+ +Q +EG + + LE Q P + +E S L +EQ +
Sbjct: 586 EEADHEVLDQKEMKQ-MEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEH 644
Query: 841 RQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEAT 900
+ + E L A E + + +++ + + H ER + E
Sbjct: 645 QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQD------ELERLKSQILELEL 698
Query: 901 RLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQE 960
+E E +L E ++++ L E+ + A L+ E R Q+++ +
Sbjct: 699 NFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEE----RDQLLSQVK 754
Query: 961 KASLDKELMAQ------KLVQAEREAQASLREQRAAHE----EDLQRLQREKEAAWRELE 1010
+ S+ EL AQ L +AER+ + E + AH+ E + L E ++ ++E
Sbjct: 755 ELSMVTELRAQVKQLEMNLAEAERQRRLDY-ESQTAHDNLLTEQIHSLSIEAKSKDVKIE 813
Query: 1011 AERAQLQS-QLQ-REQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKE 1068
+ +L QLQ EQ L+ L+++ + E+ ER + E QALS KE
Sbjct: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLE-GAERVRHISSKVEELSQALSQKE 872
Query: 1069 SEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAA 1128
E T + + L+ + + T+ Q+ +E+D+ V ++ + + Q E
Sbjct: 873 LEITKMDQLLLEKKRDVETLQ----------QTIEEKDQQ-VTEISFSMTEKMVQLNEEK 921
Query: 1129 AAHAQEVRRLQEQARDLGKQRDSCLREAEE-------LRTQLRLLEDARDGLRRELLEAQ 1181
+ E++ L+EQ L + ++ + EE L+ + A + EL
Sbjct: 922 FSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEF 981
Query: 1182 RKLRESQEGREVQRQEAGELRRSLGEGAKE-REALRRSNEELRSAVKKAESERISLKLAN 1240
L++ E R+ + Q A R+ L + E L +E + + +E+ER ++
Sbjct: 982 DLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDK 1041
Query: 1241 EDKEQK----LALLEEARTAVGKEAGELRTGLQEVERS---RLEARRELQELRRQMKM-L 1292
E+KE + +E + + E LQ + + +L A + Q L +QM L
Sbjct: 1042 ENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTL 1101
Query: 1293 DSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEA--------SLEVMRQE 1344
+ ++ AE+ A+ ++ + + G L+K S E + E
Sbjct: 1102 QDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPE 1161
Query: 1345 LQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLR 1404
L+ K+ E E +++L +L + K+ + R L +L+ + + L +
Sbjct: 1162 LE---EKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQ 1218
Query: 1405 LSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGS-PAR 1463
+ + +L ++++Q R + G+ PS + S P
Sbjct: 1219 FDEQSKENENIGDQLRQLQIQVRESID---------------GKLPSTDQQESCSSTPGL 1263
Query: 1464 DAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREF--------- 1514
+ P + E ++ LE + PS S ++ L+E
Sbjct: 1264 EEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELEL 1323
Query: 1515 -----LQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESE----- 1564
EL E +L+ Q + ++ ++ A A LQ+ + S+
Sbjct: 1324 KVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAG 1383
Query: 1565 -EARRSVDGRLSGVQAELALQEESV-----RRSERERRATLDQVATLERS--LQATESEL 1616
E R + +L +Q ++ +EE V + SE+E T Q +E+ ++A ++L
Sbjct: 1384 LEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQL 1443
Query: 1617 RA-SQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDR 1675
++E ++K + +L K++ +E+ E K ++QR+ LQ + + +
Sbjct: 1444 EMQAKEHDERIKQLQVELCEMKQKPEEI---GEESRAKQQIQRK-----LQAALISRKEA 1495
Query: 1676 EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGAL---RDKVRGLT 1732
+ ++LQ+ + SL R T+ERL +LA VE A +D V G
Sbjct: 1496 LKENKSLQEEL-SLARG-------------TIERLTKSLADVESQVSAQNKEKDTVLGRL 1541
Query: 1733 EALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQ 1792
L + L + D++L + Q L ++ + AL + L ++++
Sbjct: 1542 ALLQEERDKLITEMDRSLL----------ENQSLSSSCESLKLALEGLTEDKEKLVKEIE 1591
Query: 1793 TLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQR 1852
+L+ + E +LQ+ E+L Q E + N +++Q +++ L
Sbjct: 1592 SLKSSKIAESTEWQEKHKELQKEYEILLQSYENVS---NEAERIQHVVEAVRQEKQELYG 1648
Query: 1853 ALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREK----LRSHEDTVRLSAEKGRLDR 1908
L EA K+E E+ E++ ++ + K + K L E+ RL AE
Sbjct: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708
Query: 1909 TLTGAELEL----AEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL-ELQQEVERLRS 1963
T L A + ++++++ + L + E D+ +++ +L+ ++E S
Sbjct: 1709 TAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVS 1768
Query: 1964 AQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQE--LRRSSAPFSPPSGPPEK 2017
QA LEA E+ H + EE ++ G+ +++ L S+ P S P K
Sbjct: 1769 KQA----NLEATEK-HDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAK 1819
Score = 156 bits (394), Expect = 2e-37
Identities = 306/1413 (21%), Positives = 599/1413 (42%), Gaps = 197/1413 (13%)
Query: 70 ATEMASLLSLQEE-------NQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQAL 122
+T+ L LQEE NQ +Q+ELSRV L + E+D+L ERL L
Sbjct: 1878 STKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDL-------EERLMNQL 1930
Query: 123 RLEPGELETQEPRGLVRQSV---ELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGK 179
G + G Q V +++ +L E + +K E ++ + QLV+
Sbjct: 1931 AELNGSI------GNYCQDVTDAQIKNELLESEMKNLKK--CVSELEEEKQQLVK----- 1977
Query: 180 ILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAML 239
+ K SE+ ++ LE+ + Q+ + H+++L+ L +E+QQ L +
Sbjct: 1978 --EKTKVESEIRKEYLEKI-QGAQKEPGNKSHAKELQELL---KEKQQEVKQLQKDCIRY 2031
Query: 240 REQLDQAGSANQALSEDIRKVTNDWTRCRKELE-HREAAWRREEESFNAYFSNEHSRLLL 298
+E++ AL ++ + T +K+LE +E + E A ++LL
Sbjct: 2032 QEKIS-------ALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLL 2084
Query: 299 LWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALE 358
Q R L +K+ E LQ E ++ ++ L R E E L+
Sbjct: 2085 DDTQSEAARVLADNLKLKKE---LQSNKESVKSQMKQKDEDLE-----RRLEQAEEKHLK 2136
Query: 359 KQALLQAQLEEQLRDKV------------LREKDLAQQQMQSDLDKADLSARVTELGLAV 406
++ +Q +L+ R+KV L +KD QQ+Q +LD VT+L
Sbjct: 2137 EKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDST-----VTQLAAFT 2191
Query: 407 KRLEKQNLEKDQVNKDLTEKLEALESLRLQ---EQAALETEDGEGLQQTLRDLA------ 457
K + ++D+V D +K E S +Q E+ L+ ++ L+ LR ++
Sbjct: 2192 KSMSSLQDDRDRVI-DEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEEL 2250
Query: 458 -----------QAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRS 506
Q S +++ VQL ++ D G + L Q + S
Sbjct: 2251 KINISRLEHDKQIWESKAQTEVQLQ--QKVCDTLQGENKELLSQLEETRHLYHS------ 2302
Query: 507 PRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQD----LLGTLRKQLSDSESE 562
+ LA + S L + Q+ D+ E ++ L G +R+Q +D ++
Sbjct: 2303 ----------SQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS 2352
Query: 563 RRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEEL 622
+ + E+ L+ + + HE+ + Q++ S LLS ++ + ++ +QQ ++
Sbjct: 2353 KFSYEQLETDLQASRELTSRLHEEINMKEQKIIS---LLSGKEEAIQVAIAELRQQHDKE 2409
Query: 623 RQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKEL 682
+E E L + +EE + LEEE + AV ++ L+ ++ Q + + K +
Sbjct: 2410 IKELENLLSQEEE---ENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSM 2466
Query: 683 VEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLS 742
++ R + D Q E+ ++ L K + + E KL+ E L+ + L+
Sbjct: 2467 SSLQN--DRDRIVGDYQQLEERHLSIILEKDQLIQ-EAAAENNKLKEEIRGLRSHMDDLN 2523
Query: 743 A----LNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQE 798
+ L+ L Q + DLN+++ + ++ L Q Q +E + +LEE E E
Sbjct: 2524 SENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKEL---ENKYAKLEEKLKESE 2580
Query: 799 VARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLS-GREQELEQARREA 857
A + L S ++ ++ L +++ +L+ SQL Q+ L + + G + + E
Sbjct: 2581 EANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEE 2640
Query: 858 QRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRT---LSEEATRLRLEKEALEGSLF 914
++ AL +++++ A +E + VQ AA++ G L +E L + +
Sbjct: 2641 VHRLSALFSSSQKRIAELEEEL-VCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETE 2699
Query: 915 EVQRQLAQLEARREQLEAEGQALLLAKET--LTGELAGLRQQIIATQEKASLDKELMAQK 972
+ ++A+L R+ +E E + L++ KE LT ++ + + + Q ++ ++
Sbjct: 2700 TAEERVAELA--RDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNS----RDHANEE 2753
Query: 973 LVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELE-----------AERAQLQSQLQ 1021
L + +R+ ASL+E E+ L L RE++A E + +L QL
Sbjct: 2754 LDELKRKYDASLKELAQLKEQGL--LNRERDALLSETAFSMNSTEENSLSHLEKLNQQLL 2811
Query: 1022 REQEELL---ARLEA---EKEELSEEIAALQQERDEGLLLAESEK----QQALSLKESEK 1071
+ E+LL ++LE + + S+ +A+LQ ERD L E EK ++ ++
Sbjct: 2812 SKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDH--LWNELEKFRKSEEGKQRSAAQP 2869
Query: 1072 TALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREE----- 1126
+ ++ + +++++ + +R ++ ++ Q+Q +N +EL L+AQ +E
Sbjct: 2870 STSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQ-INQEITELHPLKAQLQEYQDKT 2928
Query: 1127 -AAAAHAQEVRR----LQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQ 1181
A +E+R+ Q + L ++ S ++ Q + +D L
Sbjct: 2929 KAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLI 2988
Query: 1182 RKLRESQEGRE-----VQRQEAGELRRSLGEGAK----EREALRRSNEELRSAVKKAESE 1232
R+LR S + QRQ + E S +G++ E E LR +L ++K+ +
Sbjct: 2989 RELRSSSSQTQPLKVQYQRQASPETSAS-PDGSQNLVYETELLRT---QLNDSLKEIHQK 3044
Query: 1233 RISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKML 1292
+ ++ N + Q LLEE T + + + L+E ++ + L +Q++ L
Sbjct: 3045 ELRIQQLNSNFSQ---LLEEKNT-LSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQEL 3100
Query: 1293 DSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKL 1352
+ + Q + + +++ E RE +Q + + L RQE+ ++ L
Sbjct: 3101 QAGPLNIDVAPGAPQEKNGVHRKSDPEELREP---QQSFSEAQQQLCNTRQEVNELRKLL 3157
Query: 1353 QEQEGEFRTRERRLLGSLEEARGTEKQQLDHAR 1385
+E+ + E L + E+ R E + D +R
Sbjct: 3158 EEERDQRVAAENALSVAEEQIRRLEHSEWDSSR 3190
Score = 96.7 bits (239), Expect = 2e-19
Identities = 187/914 (20%), Positives = 361/914 (39%), Gaps = 112/914 (12%)
Query: 1 MSLGLARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTR--- 57
+S L + +E + LE +I+ E+ + Q L D Q + RE+ +R
Sbjct: 2324 LSNSLEKCKEQKGNLEGIIRQQEADI--QNSKFSYEQLETDLQAS------RELTSRLHE 2375
Query: 58 --NLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVS 115
N+ + + LL E A +++ E Q +E+ +E+LL+Q E L +
Sbjct: 2376 EINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAV 2435
Query: 116 ERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQR 175
++ Q + L+T + +++++ + QL S+ + + + Q + R Q+
Sbjct: 2436 DKTNQLMET----LKT-----IKKENIQQKAQLD----SFVKSMSSLQNDRDRIVGDYQQ 2482
Query: 176 LQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQ-QRSASLAQ 234
L+ + L +L Q+ + +L+++ H DL S +L+ E Q L Q
Sbjct: 2483 LEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQ 2542
Query: 235 VNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHS 294
V + Q Q ++++ N + + ++L+ E A SFNA +
Sbjct: 2543 VITIKDSQQKQLLEVQLQQNKELE---NKYAKLEEKLKESEEANEDLRRSFNALQEEKQD 2599
Query: 295 RLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAG-LGL-STGLRLAES- 351
L +++ + +S+ L R A+QE G LGL L++ E
Sbjct: 2600 ----LSKEIESLKVSISQ---------------LTRQVTALQEEGTLGLYHAQLKVKEEE 2640
Query: 352 --RAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQ-SDLDKADLSARVTELGLAVKR 408
R A A+LEE+L V +K+ A++ + D K +L + G+
Sbjct: 2641 VHRLSALFSSSQKRIAELEEEL---VCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNE 2697
Query: 409 LEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSES-- 466
E ++ +DL E ++++ + T++ +GL ++ +++ S S
Sbjct: 2698 TETAEERVAELARDLVE---------MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRD 2748
Query: 467 --GVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALI 524
+L +R DAS L L Q + R + + S L +
Sbjct: 2749 HANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEE--NSLSHLEKL 2806
Query: 525 HSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAH 584
+ L + Q+ + + E S + + + K ++ ++ER L +L++ R +G ++
Sbjct: 2807 NQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSA 2866
Query: 585 ED---AQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRD 641
+ EVQ L+ A L ++ L L+ QQQ ++ QE +L + +L+ +D
Sbjct: 2867 AQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQD 2926
Query: 642 R---LEEEQEDAVQDGARVRREL-----ERSHRQLEQLEGKRSVL---------AKELVE 684
+ + QE+ Q+ + EL E+S ++ + K L L
Sbjct: 2927 KTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQN 2986
Query: 685 VREALSRATLQRDMLQAEKAEVAEALTKAEAGR-----VELELSMTKLRAEEASLQDSLS 739
+ L ++ Q L+ + A T A E EL T+L +
Sbjct: 2987 LIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKEL 3046
Query: 740 KLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQR---QAEQEATVAREEQERLEELRLE 796
++ LN + +Q + N L QL + +L+ Q+ V ++ + L+ L
Sbjct: 3047 RIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLN 3106
Query: 797 QEVA-----------RQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSG 845
+VA R+ LR +Q+ +QQL R E ++L++ L + Q
Sbjct: 3107 IDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVA 3166
Query: 846 REQELEQARREAQR 859
E L A + +R
Sbjct: 3167 AENALSVAEEQIRR 3180
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 211 bits (537), Expect = 6e-54
Identities = 406/2071 (19%), Positives = 854/2071 (41%), Gaps = 300/2071 (14%)
Query: 76 LLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPR 135
+ L+EE Q+ QQ +++ S E+D+ L+Q LR P ++ +P
Sbjct: 189 IAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPL 248
Query: 136 GLVRQSVELRRQLQE---------EQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKR 186
+ E+ + + E + + L+ Q+ +RQ L++R + I +K++
Sbjct: 249 PQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQ 308
Query: 187 CS-------ELEQQLLERSGELEQQR----LRDTEHSQDLESALIRLEE-EQQRSASLAQ 234
C+ L++QL ER ELE+ + T+ L A +E+ EQ + +A+
Sbjct: 309 CTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAE 368
Query: 235 VNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHRE-AAWRREEESFNAYFSNEH 293
+ E L+ L I+++T R++ E E AA+ E++ + E
Sbjct: 369 TKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEE 428
Query: 294 SRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRA 353
+R L + ++ +E + + L EL+R + V + + +S
Sbjct: 429 ARRKLK----AEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDV---------MKKSSE 475
Query: 354 EAALEKQALLQAQL---EEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLE 410
E + Q L + +L E++L K+ + Q+QM+ L+K+
Sbjct: 476 EQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQ------------SEYL 523
Query: 411 KQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQL 470
K + EK+Q ++ ALE L LQ++A L + + LRDL Q + ++L
Sbjct: 524 KISQEKEQ------QESLALEELELQKKAILTESENK-----LRDLQQEAETYRTRILEL 572
Query: 471 SGS-ERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALH 529
S E++ + + L+ + + + ++ +L AL
Sbjct: 573 ESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHK-----TELESLKHQQDALW 627
Query: 530 KRQLQVQDMRGRYEASQDLLGTLRKQLSDS--ESERRALEEQLQRLRDKTDGAMQAHEDA 587
+LQV ++ +Y+ + L +Q ++ + + + ++ + +KT ++ +
Sbjct: 628 TEKLQV--LKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKT---LEKLDVK 682
Query: 588 QREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQERE-KLQAAQEELRRQRDRLEEE 646
Q E++ L S + + + L L V + Q ++++QE E K+ + ++Q D + +E
Sbjct: 683 QTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKE 742
Query: 647 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKEL---VEVREA--------LSRATLQ 695
E ++Q R + L+ QLE L +R KE VE EA L +A+ +
Sbjct: 743 HEVSIQ---RTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
Query: 696 RDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQD---- 751
D+ Q+ ++ E E +L+ + L E L ++++ A + + +
Sbjct: 800 LDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAH 859
Query: 752 KLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVA 811
K+ + L+ QLE++ S ++ + + Q + +LE+ EQE +Q L +
Sbjct: 860 KIQVQDLMQQLEKQNSEMEQKVKSLTQVY------ESKLEDGNKEQEQTKQILVEKENMI 913
Query: 812 EQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREK 871
Q +E ++++ L + S ++ + L+ +E E + ++++E +++ A+E
Sbjct: 914 LQMREGQKKEIEILTQKLSAKEDSIHILN-------EEYETKFKNQEKKMEKVKQKAKEM 966
Query: 872 EALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLE 931
+ K+ + L +EA +L+KE LE + E+ ++ Q A+ ++
Sbjct: 967 QETLKK---------------KLLDQEA---KLKKE-LENTALELSQKEKQFNAKMLEMA 1007
Query: 932 AEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAH 991
A + + ++ ++QI + E + + + + E++ E + H
Sbjct: 1008 QANSAGI--SDAVSRLETNQKEQIESLTE---VHRRELNDVISIWEKKLNQQAEELQEIH 1062
Query: 992 EEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQE--- 1048
E LQ ++E+E A E ++ + EKEE+++EI L++E
Sbjct: 1063 EIQLQ--EKEQEVA-----------------ELKQKILLFGCEKEEMNKEITWLKEEGVK 1103
Query: 1049 RDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQ--- 1105
+D L +E Q+ L K + +L++ + L + +++ + ++ QEQ
Sbjct: 1104 QDTTL----NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVE 1159
Query: 1106 -------DRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGK-------QRDS 1151
D+ V+ LTS+L+ + + ++H + + L++++ + K Q D
Sbjct: 1160 LKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDI 1219
Query: 1152 CLREAEEL-----RTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLG 1206
C ++ E L + + + + + Q + + +E ++ EL L
Sbjct: 1220 CCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLR 1279
Query: 1207 EGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRT 1266
+ +E+ L S ++ +++ E++ S+K E L + A+ KE G +
Sbjct: 1280 QLTEEQNTLNISFQQATHQLEEKENQIKSMKADIES-------LVTEKEALQKEGGNQQQ 1332
Query: 1267 GLQEVERSRLEARRELQE-------LRRQMKMLDSENTRLGRELAEL----QGRLALGER 1315
E E + ++EL E ++ ++K E + L ++L +L Q ++L E+
Sbjct: 1333 AASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEK 1392
Query: 1316 A------EKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGS 1369
K+ E L ++ ++ + +E A ++ + +F +++
Sbjct: 1393 EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSR 1452
Query: 1370 LEEARGTEKQ-QLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRA 1428
+ + T K+ Q+ LELK + A + ++ L + + + + +E +
Sbjct: 1453 FTQHQNTVKELQIQ----LELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSK 1508
Query: 1429 AEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQP 1488
E + L + L+ AR E + T+E ++
Sbjct: 1509 MEKKESNLETELK-----------------SQTARIMELEDH----ITQKTIEIESLNEV 1547
Query: 1489 PSPGPATSPASPDLDPEAVRGALREFLQELRSAQRER-DELRTQTSALNRQLAEMEAERD 1547
D++ + + L+ F QEL + R E + L Q+ M+AE +
Sbjct: 1548 LK----NYNQQKDIEHKELVQKLQHF-QELGEEKDNRVKEAEEKILTLENQVYSMKAELE 1602
Query: 1548 SATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLER 1607
+ + +V EE ++++ RL A A E R++E++ A Q+ L +
Sbjct: 1603 TKKKELEHVNLSVKSKEEELKALEDRLESESA--AKLAELKRKAEQKIAAIKKQL--LSQ 1658
Query: 1608 SLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQR 1667
+ E + ++ +S++ + E + L+E L + ES + + RS +
Sbjct: 1659 MEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAY 1718
Query: 1668 SRLGLSDREAQAQ-ALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRD 1726
+ +D + Q ++++ LQR + + E ++R+ + S +R
Sbjct: 1719 TEQEEADSQGCVQKTYEEKISVLQRNLTEKEK-------LLQRVGQEKEETVSSHFEMRC 1771
Query: 1727 KVRGLTEALAQSSASLNSTRDKNLHLQK---------ALTACEH-----------DRQVL 1766
+ + L + A + + HLQ+ +L +H +Q L
Sbjct: 1772 QYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNL 1831
Query: 1767 QERLDAARQALSEARKQSSSLGEQVQTLRG-EVADLELQRVEAEG------QLQQLREVL 1819
+ D ++ L E L ++++ L V E+ RVE E +LQ L+++
Sbjct: 1832 ENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMD 1891
Query: 1820 RQRQEGEAAALNTVQKLQDERRLLQERLGS--------LQRALAQLEAEKREVERSALRL 1871
+ + E NT +K + L+Q +L S L+ LA E EK+++ + +RL
Sbjct: 1892 GRNKPTELLEENTEEK--SKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRL 1949
Query: 1872 EKDRVALRRT----LDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQL 1927
+KD LR+ L+ +++E + E+ ++ E L T +L + E Q+ Q
Sbjct: 1950 QKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQL-MREFNTQLAQK 2008
Query: 1928 EAQV-VVLEQSHSPAQLEVDAQ---QQQLELQQEVERLRSAQAQTERT-------LEARE 1976
E ++ + ++++ + AQ EV+A+ Q E Q ++++ +RT L+ARE
Sbjct: 2009 EQELEMTIKETINKAQ-EVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDARE 2067
Query: 1977 RAHRQRVRGLEEQVSTLKGQLQQELRRSSAP 2007
+VR L+ Q+ L+ + QQ+L + P
Sbjct: 2068 EEMTAKVRDLQTQLEELQKKYQQKLEQEENP 2098
Score = 202 bits (513), Expect = 4e-51
Identities = 423/2126 (19%), Positives = 892/2126 (41%), Gaps = 331/2126 (15%)
Query: 78 SLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGL 137
SL +E L Q L R+E L+ R + EL Y + L++ + G L + + L
Sbjct: 133 SLNKEQ--LIQRLRRMERSLSSYRGKYSELVTAY----QMLQREKKKLQGILSQSQDKSL 186
Query: 138 VRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKI--LQYKKRCSELEQQLL 195
R+ ELR +LQ +Q + + + + + + Q + LQ ++ L+ + R + +L
Sbjct: 187 -RRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVL 245
Query: 196 ERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQ---LDQAGSANQA 252
+ +LE Q T+ ++ ES + E+ +L + ++ Q L + Q+
Sbjct: 246 KPLPQLEPQAEVFTK-EENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQS 304
Query: 253 LSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQ---------- 302
E +T++ +++L+ R +E E E ++L+ R
Sbjct: 305 HKEQCTLLTSEKEALQEQLDER----LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQ 360
Query: 303 -----VVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAAL 357
+ +R + E E ++ QL + + + +E R A E AL
Sbjct: 361 DKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKAL 420
Query: 358 -------EKQALLQAQLEEQLR--DKVLREKDLAQQQMQSDL--DKADLSARVTELGLA- 405
E + L+A+++EQ++ +K E+ ++ QQ S + + D+ + +E +A
Sbjct: 421 STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAK 480
Query: 406 VKRLEKQNLEKDQVNKDLTEKLEALE-SLRLQEQAALETEDGEGLQQTLRDLAQAVLSDS 464
+++L ++ L + + ++LT+KL+ E + Q + ALE E L+ + Q L+
Sbjct: 481 LQKLHEKELARKE--QELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALE 538
Query: 465 ESGVQLSGSERTADASNGSLRGLSGQ----RTPSPPRRSSPGRGRSPRRGPSPACSDSST 520
E +Q + S LR L + RT SS + + S D +
Sbjct: 539 ELELQ---KKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQS---KDLAV 592
Query: 521 LALIHSALHKRQLQVQDMRGRYEA-----SQDLLGTLRKQL------SDSESERRALEEQ 569
H +++ V + + E QD L T + Q+ ++ E R E++
Sbjct: 593 HLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQE 652
Query: 570 LQRLRDKTDGAMQAH------------EDAQREVQRLRSANELLSREKSNLAHSLQVAQQ 617
+ L + QAH + Q E++ L S + + + L L V +
Sbjct: 653 KETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKD 712
Query: 618 QAEELRQERE-KLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRS 676
Q ++++QE E K+ + ++Q D + +E E ++Q R + L+ QLE L +R
Sbjct: 713 QTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQ---RTEKALKDQINQLELLLKERD 769
Query: 677 VLAKE---LVEVREA--------LSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMT 725
KE VE EA L +A+ + D+ Q+ ++ E E +L+ +
Sbjct: 770 KHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829
Query: 726 KLRAEEASLQDSLSKLSALNESLAQD----KLDLNRLVAQLEEEKSALQGRQRQAEQEAT 781
L E L ++++ A + + + K+ + L+ QLE++ S ++ ++ +
Sbjct: 830 DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME------QKVKS 883
Query: 782 VAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSR 841
+ + + +LE+ EQE +Q L + Q +E ++++ L + S ++ + L+
Sbjct: 884 LTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNE 943
Query: 842 Q----LSGREQELEQARREAQRQVEALERAAREKEA-LAKEHAGLAVQLVAAERE----- 891
+ +E+++E+ +++A+ E L++ ++EA L KE A++L E++
Sbjct: 944 EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKM 1003
Query: 892 -------GRTLSEEATRLRLEKEALEGSLFEVQRQ---------LAQLEARREQLEAEGQ 935
+S+ +RL ++ SL EV R+ +L + E+L+ +
Sbjct: 1004 LEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHE 1063
Query: 936 ALLLAKETLTGELAGLRQQIIATQ-EKASLDKEL--MAQKLVQAE---REAQASLREQRA 989
L KE E+A L+Q+I+ EK ++KE+ + ++ V+ + E Q L+ Q++
Sbjct: 1064 IQLQEKEQ---EVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLK-QKS 1119
Query: 990 AHEEDLQRLQREKEAAWRELEAERAQLQSQ---LQREQEELLARLEAEKEELSEEIAALQ 1046
AH L + + + +A +LE + + + LQ + EL E +K ++SE + L+
Sbjct: 1120 AHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLK 1179
Query: 1047 QERDEGLLLAESEKQQALSL--KESEKTALSEKL------------------------MG 1080
+E L S ++ SL K E LSE+L +
Sbjct: 1180 TTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINIS 1239
Query: 1081 TRHSLATISLEMERQKRDAQSRQEQ--DRSTVNALTSELRDLRAQREEAAAAHAQEVRRL 1138
+ + A +S Q R + ++ TV+ L ++LR L ++ + Q +L
Sbjct: 1240 SSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQL 1299
Query: 1139 QE---QARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQR 1195
+E Q + + +S + E E L+ + + A + + +++L E+ + +
Sbjct: 1300 EEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMK 1359
Query: 1196 QEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEART 1255
+E E + + +K+ L N +L++++ +E E L + E+K LL++ +
Sbjct: 1360 EELKEKKVEISSLSKQ---LTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQ- 1415
Query: 1256 AVGKEAGELRTGLQEVERSRLEARRELQELRRQM----KMLDSENTRLGRELAELQGRLA 1311
+L + + + ++ A ++ + + K S T+ + ELQ +L
Sbjct: 1416 -------DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLE 1468
Query: 1312 LGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEG----EFRTRERRL- 1366
L + E + L++ L + + ++ E++ + K++++E E +++ R+
Sbjct: 1469 LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIM 1528
Query: 1367 ------------LGSLEEARGTEKQQLD-HARGLELKLEAARAEAAELGLRLSAAEGRAQ 1413
+ SL E QQ D + L KL+ + E R+ AE +
Sbjct: 1529 ELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL 1588
Query: 1414 GLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEG 1473
LE ++ ++ + + +L + +++ +++ + +
Sbjct: 1589 TLENQVYSMKAELETKKKELEHVNLSVK--------------------SKEEELKALEDR 1628
Query: 1474 LNSPSTLECSPGSQPPSPGPATSP----ASPDLDPEAVRGALREFLQELRSAQRERDELR 1529
L S S + + + A + + E + L EL + +ER+
Sbjct: 1629 LESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERER-- 1686
Query: 1530 TQTSALNRQLAEMEAERDSA--TSRARQLQKAVAESEEA------RRSVDGRLSGVQAEL 1581
+ L +L +E+ + R+ + A E EEA +++ + ++S +Q L
Sbjct: 1687 -EVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNL 1745
Query: 1582 ALQEESVRRSERERRATLDQVATLERSLQATESELRAS-QEKISKMKANETKLEGDKRRL 1640
+E+ ++R +E+ T+ ++ E+R QE++ K++ E K D+ +
Sbjct: 1746 TEKEKLLQRVGQEKEETV-----------SSHFEMRCQYQERLIKLEHAEAKQHEDQSMI 1794
Query: 1641 KEVLDASESRTVKLEL---QRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSE 1697
+ + E + K L Q EG G ++ +A+ Q L++ D +Q+ + + E
Sbjct: 1795 GHLQEELEEKNKKYSLIVAQHVEKEG-------GKNNIQAK-QNLENVFDDVQKTLQEKE 1846
Query: 1698 VKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALT 1757
+ L+ ++ L+ L + +E +++ E L Q+ ++ R+K L + T
Sbjct: 1847 LTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKL-QALQQMDG-RNKPTELLEENT 1904
Query: 1758 ACEHDRQVLQERLDAARQA--------LSEARKQSSSLGEQVQTLRGEVADLELQRVEAE 1809
+ ++Q +L + +A L+ A ++ LG+++ L+ DL + R E +
Sbjct: 1905 EEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQ---KDLRMLRKEHQ 1961
Query: 1810 GQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRAL-----AQLEAEKREV 1864
+L+ L++ Q +E +K++ E+ L+ + S + L QL +++E+
Sbjct: 1962 QELEILKKEYDQERE---------EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL 2012
Query: 1865 ERSALRLEKDRVALRRTLDK---VEREKLRSHED----TVRLSAEKG--------RLDRT 1909
E + ++ T++K VE E L SH++ ++ AEK R +
Sbjct: 2013 E----------MTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEI 2062
Query: 1910 LTGAELELA----EAQRQIQQLEAQV-VVLEQSHSPAQLEVDAQQQQLELQQEVERLRSA 1964
L E E+ + Q Q+++L+ + LEQ +P V + Q +L Q+ + +
Sbjct: 2063 LDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDS 2122
Query: 1965 QAQTERTLEARERAHRQRVRGLEEQV 1990
+ +E+ R+++ LE+++
Sbjct: 2123 --------KLKEQEFREQIHNLEDRL 2140
Score = 87.0 bits (214), Expect = 2e-16
Identities = 188/916 (20%), Positives = 362/916 (39%), Gaps = 107/916 (11%)
Query: 56 TRNLSQPESPVLLPATEMASLLS----LQEENQLLQQELSRVEDLLAQSRAERDELAIKY 111
T L + E+ + ++ SL++ LQ+E QQ S E + Q + E E
Sbjct: 1296 THQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAV 1355
Query: 112 NAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQ--LQEEQASYRRKLQAYQEGQQRQ 169
+ E L++ ++E L Q L +V+L+ L E++A+ + Y E +
Sbjct: 1356 TLMKEELKEK-KVEISSLSKQ----LTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCEL 1410
Query: 170 AQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRL----RDTEHSQDLESALIRLEEE 225
VQ L K+ K +Q+ + S + + + R T+H ++ I+LE +
Sbjct: 1411 LDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELK 1470
Query: 226 QQRSASLAQVNAMLREQLDQAGSANQALSEDI--------RKVTNDWTRCRK------EL 271
+ + + +L+E+LDQ L ++ +K +N T + EL
Sbjct: 1471 SKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMEL 1530
Query: 272 EHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELART 331
E E ES N N + + + + + LV +++ F E LG E
Sbjct: 1531 EDHITQKTIEIESLNEVLKNYNQQ------KDIEHKELVQKLQHFQE-----LGEEKDNR 1579
Query: 332 SRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLD 391
+ +E L L ++ +AE +K+ L L + +++ L+ + + + +S
Sbjct: 1580 VKEAEEKILTLEN--QVYSMKAELETKKKELEHVNLSVKSKEEELKALE-DRLESESAAK 1636
Query: 392 KADLSARVTELGLAVKR-LEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQ 450
A+L + + A+K+ L Q EK++ K TE + + +LQE+ E L+
Sbjct: 1637 LAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLK 1696
Query: 451 QTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRG 510
++ ++ + + +E+ S G ++ ++ R + R G
Sbjct: 1697 SVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVG 1756
Query: 511 PSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQ- 569
+ SS + +R ++++ + Q ++G L+++L + + + Q
Sbjct: 1757 QEKEETVSSHFEM-RCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQH 1815
Query: 570 LQRLRDKTD-----GAMQAHEDAQREVQRLRSANELLSRE----KSNLAHSLQVAQQQAE 620
+++ K + +D Q+ +Q ++L ++ S L +V + + E
Sbjct: 1816 VEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEME 1875
Query: 621 ELRQEREKLQAAQEELRRQR--DRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVL 678
EL + EKLQA Q+ R + + LEE E+ + + L Q LE K +
Sbjct: 1876 ELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGA 1935
Query: 679 AKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSL 738
+E ++ + + R ML+ E + E L K E K++ E+ L+
Sbjct: 1936 EREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQERE-----EKIKQEQEDLE--- 1987
Query: 739 SKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQE 798
L N + QL E + Q Q++ E E T+ E + QE
Sbjct: 1988 --------------LKHNSTLKQLMREFNT-QLAQKEQELEMTIK-------ETINKAQE 2025
Query: 799 VARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQ 858
V + LE QE Q L + + L+ + L RE+E+ R+ Q
Sbjct: 2026 VEAELLESH-------QEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQ 2078
Query: 859 RQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLF---E 915
Q+E L++ ++K +E+ G + T+ E T+L + + S E
Sbjct: 2079 TQLEELQKKYQQK-LEQEENPG---------NDNVTIMELQTQLAQKTTLISDSKLKEQE 2128
Query: 916 VQRQLAQLEARREQLE 931
+ Q+ LE R ++ E
Sbjct: 2129 FREQIHNLEDRLKKYE 2144
Score = 51.2 bits (121), Expect = 1e-05
Identities = 101/489 (20%), Positives = 206/489 (42%), Gaps = 64/489 (13%)
Query: 1546 RDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATL 1605
+ + +QLQ+A+A ++ + S + ++ RE T L
Sbjct: 6 KQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKL 65
Query: 1606 ERSLQATESELRAS-QEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGE 1664
+ + + ES R+ +E + + + E+ + R LD +S T +
Sbjct: 66 QLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDL-DSSTASFDPP------- 117
Query: 1665 LQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGAL 1724
SD +++A+ L DSL ++ ++ ++ ++ G +++ + L
Sbjct: 118 --------SDMDSEAEDLVGNSDSLNKEQLIQRLRR--MERSLSSYRGKYSELVTAYQML 167
Query: 1725 RDKVRGLTEALAQSSASLNSTRDKNLH----LQKALTACEHDRQVLQERLDAARQALSEA 1780
+ + + L L+QS +DK+L L++ L + ++ LQE DA+ L E
Sbjct: 168 QREKKKLQGILSQS-------QDKSLRRIAELREELQMDQQAKKHLQEEFDAS---LEEK 217
Query: 1781 RKQSSSLGEQVQTLRGEVAD--LELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQD 1838
+ S L QV L+ + + + + ++ QL+ EV + + E+ V+
Sbjct: 218 DQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTS 277
Query: 1839 ERRL--LQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDK--VEREKLRS-- 1892
+ L LQ+R+ + L + + + + L ++ AL+ LD+ E EK++
Sbjct: 278 VKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLH 337
Query: 1893 -HEDT---VRLSAEKGRLDRTLTGAELELAEAQRQIQQ-LEAQVVVLEQSHSPAQLEVDA 1947
E T +L K +++ + +AE +RQ+ + LE + + Q S + ++
Sbjct: 338 MAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIK-QMTT 396
Query: 1948 QQQQLELQQE------VERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKG------ 1995
Q ++L Q+E E L A + ++T EAR + + ++EQ+ T++
Sbjct: 397 QGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAE----MDEQIKTIEKTSEEER 452
Query: 1996 -QLQQELRR 2003
LQQEL R
Sbjct: 453 ISLQQELSR 461
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 209 bits (531), Expect = 3e-53
Identities = 328/1273 (25%), Positives = 540/1273 (42%), Gaps = 212/1273 (16%)
Query: 757 RLVAQLEEEKSALQGRQRQAEQEATVAREEQERL-EELRLEQEVARQGLEGSLRVAEQAQ 815
R + ++++SAL+ QR + + RL +++ +V RQ R A++ Q
Sbjct: 829 RAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQAR-AQELQ 887
Query: 816 EALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALER----AAREK 871
+ E Q + R E +LQ ++AQL + R + EQ R EA+ EA E AAR++
Sbjct: 888 KVQELQQQSAR-EVGELQGRVAQLEEE---RARLAEQLRAEAELCAEAEETRGRLAARKQ 943
Query: 872 EALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLE 931
E ++LV +E E R EE +++ E +Q+ + +LEA E E
Sbjct: 944 E----------LELVVSELEARVGEEEECSRQMQTEKKR-----LQQHIQELEAHLEAEE 988
Query: 932 AEGQALLLAKETLTGELAGLRQQIIATQE---KASLDKELMAQKLVQAEREAQASLREQR 988
Q L L K T ++ + ++ ++ K S +++L+ +L AE +QA+ E++
Sbjct: 989 GARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL--AEFSSQAAEEEEK 1046
Query: 989 AAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQE 1048
+ L +L+ + EA ++E +R + + + ++E E+L RL+ E EL E++ QQ
Sbjct: 1047 V---KSLNKLRLKYEATIADME-DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQR 1102
Query: 1049 RDE---GLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATIS-----LEMERQKRDAQ 1100
+E L E E Q AL+ E E A ++ L R + A ++ LE ER R
Sbjct: 1103 AEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKA 1162
Query: 1101 SRQEQDRST-VNALTSELRD----------LRAQREEAAAA---HAQEVRRLQEQA-RDL 1145
+Q +D + AL EL D LR++RE+ +E R+ E A ++L
Sbjct: 1163 EKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQEL 1222
Query: 1146 GKQRDSCLREAEELRTQLR-----------LLEDARDGLRRELLEAQRKLRESQEGR--- 1191
++ L E E Q R LE LR EL Q +E ++ R
Sbjct: 1223 RQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRL 1282
Query: 1192 EVQRQE----AGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISL----------- 1236
E+Q QE AG+ R+ E A++ + + E + A+ +AES+ I L
Sbjct: 1283 ELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQL 1342
Query: 1237 ----KLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKML 1292
+L E+ KLAL R A+ EA LR L+E +R A RELQ + Q+
Sbjct: 1343 HDAQELLQEETRAKLALGSRVR-AMEAEAAGLREQLEEEAAARERAGRELQTAQAQL--- 1398
Query: 1293 DSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKL 1352
+ R E G L GE A + + RE L QRL + +++ + + + Q++L
Sbjct: 1399 ----SEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQEL 1454
Query: 1353 QEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRA 1412
+ + ++R+L+ +LE+ + Q L + L+ R A G E RA
Sbjct: 1455 DDATMDLE-QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG---REREARA 1510
Query: 1413 QGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGE 1472
L L + R E Q LR+ L L + + V AE +
Sbjct: 1511 LSLTRALEEEQEAREELERQNRALRAELE---ALLSSKDDVGKSVHELERACRVAEQAAN 1567
Query: 1473 GLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALR-EFLQELRSAQRERDELRTQ 1531
L + T T+ L E AL+ + ++L+ +E R Q
Sbjct: 1568 DLRAQVT---------ELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQ 1618
Query: 1532 TSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRS 1591
L +QL + E ERD +Q AVA AR+ ++G L ++A++A + +
Sbjct: 1619 ---LAKQLRDAEVERD---EERKQRTLAVA----ARKKLEGELEELKAQMASAGQGKEEA 1668
Query: 1592 ERERRATLDQVATLERSLQATESELRASQEKI-SKMKANETKLEGDKRRLKEVLDASESR 1650
++ R Q+ L R ++ E R S+E+I S+ + +E +L+G
Sbjct: 1669 VKQLRKMQAQMKELWREVE----ETRTSREEIFSQNRESEKRLKG--------------- 1709
Query: 1651 TVKLELQRRSLEGELQR--SRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVE 1708
LE E+ R L SDR A+ QA QDR D + +VA+ + +
Sbjct: 1710 ----------LEAEVLRLQEELAASDR-ARRQAQQDR-DEMADEVANGNLSKAAILEEKR 1757
Query: 1709 RLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQE 1768
+L G L ++EE L E QS++ L + R + L LQ + L
Sbjct: 1758 QLEGRLGQLEEE----------LEE--EQSNSELLNDRYRKLLLQV---------ESLTT 1796
Query: 1769 RLDAARQALSEARKQSSSLGEQVQTLRGE---------------VADLELQRVEAEGQL- 1812
L A R ++A L Q+Q LRG +A LE + +AE QL
Sbjct: 1797 ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLE 1856
Query: 1813 QQLREVL---RQRQEGEAAALNTVQKLQDERRLLQERLGSLQRA---LAQLEAEKREVER 1866
Q+ RE + + + E V ++++ERR+ + L++ + QL+ + E E
Sbjct: 1857 QETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEE 1916
Query: 1867 SALRLEKDRVALRRTLDKV--EREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQI 1924
A R + R L+R L+ V E + T+R +G L T RQ+
Sbjct: 1917 EASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFT--------TRTVRQV 1968
Query: 1925 QQLEAQVVVLEQS 1937
+LE V E++
Sbjct: 1969 FRLEEGVASDEEA 1981
Score = 189 bits (481), Expect = 2e-47
Identities = 260/1069 (24%), Positives = 454/1069 (42%), Gaps = 141/1069 (13%)
Query: 530 KRQLQ--VQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKT---------- 577
K++LQ +Q++ EA + L+ + +E++ + EE L L D+
Sbjct: 970 KKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLL 1029
Query: 578 -DGAMQAHEDAQREVQRLRSANELLSREKSNLAHS---LQVAQQQAEELRQEREKLQAAQ 633
D + A E ++++S N+L + ++ +A L+ ++ +EL + + +L
Sbjct: 1030 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1089
Query: 634 EELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRAT 693
EL+ Q ++ E+ R EL+ + + E G R+ L K L E + AL+ A
Sbjct: 1090 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEA- 1148
Query: 694 LQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKL 753
++ L++E+ A TKAE R +L + LR E L+D+L +A E ++ +
Sbjct: 1149 --QEDLESERV----ARTKAEKQRRDLGEELEALRGE---LEDTLDSTNAQQELRSKREQ 1199
Query: 754 DLNRLVAQLEEE----KSALQG-RQRQAEQEATVARE-EQERL-----EELRLEQEVARQ 802
++ L LEEE ++A+Q RQR + +A + EQ R E+ RL E
Sbjct: 1200 EVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVS 1259
Query: 803 GLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVE 862
L L + A++ EQ+ L + ++Q + R + ++L++A+ E +
Sbjct: 1260 ELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSG 1319
Query: 863 ALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRL----EKEALEGSLFEVQR 918
AL A + L+KE + QL + + L +E TR +L A+E ++
Sbjct: 1320 ALNEAESKTIRLSKELSSTEAQL----HDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1375
Query: 919 QLAQLEARREQLEAE---GQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQ 975
QL + A RE+ E QA L E AG + + +A+ + E + Q+L +
Sbjct: 1376 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAE 1435
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQ---EELLARLE 1032
R +R RLQ+E + A +LE +R QL S L+++Q ++LLA +
Sbjct: 1436 KTETVDRLERGRR--------RLQQELDDATMDLEQQR-QLVSTLEKKQRKFDQLLAEEK 1486
Query: 1033 A------EKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALS---EKLMGTRH 1083
A E+ E +E ++ R L A E+Q+A E + AL E L+ ++
Sbjct: 1487 AAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKD 1546
Query: 1084 SLATISLEMERQKRDAQSRQEQDRSTVNALTSEL---RDLRAQREEAAAA-HAQEVRRLQ 1139
+ E+ER R A+ R+ V L EL D + + E A Q R LQ
Sbjct: 1547 DVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQ 1606
Query: 1140 -------EQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGRE 1192
E+ R L KQ E +E R Q L AR L EL E + ++ + +G+E
Sbjct: 1607 GRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKE 1666
Query: 1193 VQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESE---------RISLKLANEDK 1243
++ +++ + E +E E R S EE+ S +++E R+ +LA D+
Sbjct: 1667 EAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDR 1726
Query: 1244 EQ--------------------KLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQ 1283
+ K A+LEE R G+ G+L L+E + + +
Sbjct: 1727 ARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGR-LGQLEEELEEEQSNSELLNDRYR 1785
Query: 1284 ELRRQMKMLDSE--------------NTRLGRELAELQGRLALGERAEKESRRETL-GLR 1328
+L Q++ L +E +L R++ EL+GRL + + + T+ L
Sbjct: 1786 KLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALE 1845
Query: 1329 QRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLE 1388
+L + E LE +E ++ + ++ E R + ++ +EE R Q D
Sbjct: 1846 SKLAQAEEQLEQETRERILSGKLVRRAE----KRLKEVVLQVEEERRVADQLRDQLEKGN 1901
Query: 1389 LKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGR 1448
L+++ + + E S A+ + L+ EL V + ++ LR+ LRRG
Sbjct: 1902 LRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRG----- 1956
Query: 1449 APSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSP 1497
P+ + EG+ S E + PSP P SP
Sbjct: 1957 -------PLTFTTRTVRQVFRLEEGVASDEEAEEAQPGSGPSPEPEGSP 1998
Score = 182 bits (461), Expect = 4e-45
Identities = 275/1154 (23%), Positives = 482/1154 (41%), Gaps = 123/1154 (10%)
Query: 71 TEMASLLSLQEENQLLQ---QELSRVEDLLAQSRAERDELAIKYNAVSE---RLEQALRL 124
T++ LL + ++++LQ QEL +V++L QS E EL + + E RL + LR
Sbjct: 864 TKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRA 923
Query: 125 EPGEL--ETQEPRG-LVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKIL 181
E EL E +E RG L + EL + E +A + + ++ Q + +L Q +Q
Sbjct: 924 E-AELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQ---- 978
Query: 182 QYKKRCSELEQQLLERSG---ELEQQRLRDTEHSQDLESALIRLEEEQQRSAS------- 231
ELE L G +L+ +++ + E L+ LE++ + +
Sbjct: 979 -------ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLED 1031
Query: 232 -LAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFS 290
LA+ ++ E+ ++ S N+ + + + R RKE + R+ E E
Sbjct: 1032 RLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQ-----ELEKLKRRLD 1086
Query: 291 NEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAE 350
E S L Q+V ++ E++ R +L LAR A E G L E
Sbjct: 1087 GESSELQ---EQMVEQQQRAEELRAQLGRKEEELQAALAR---AEDEGGARAQLLKSLRE 1140
Query: 351 SRAEAA-----LEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARV-TELGL 404
++A A LE + + + + E+Q RD + E + + +++ LD + + ++
Sbjct: 1141 AQAALAEAQEDLESERVARTKAEKQRRD-LGEELEALRGELEDTLDSTNAQQELRSKREQ 1199
Query: 405 AVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAAL--ETEDGEGLQQTLRDLAQAVLS 462
V L+K E+ ++++ ++L L E A + G+G + R +A +S
Sbjct: 1200 EVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVS 1259
Query: 463 DSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSP-----RRGPSPACSD 517
+ + +LS + R L Q R R R+ +R + +
Sbjct: 1260 ELRA--ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENV 1317
Query: 518 SSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKT 577
S L S + ++ + +Q+LL + S RA+E + LR++
Sbjct: 1318 SGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQL 1377
Query: 578 DGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQV-------AQQQAEELRQEREKLQ 630
+ A E A RE+Q ++ R + A +L+ A ++AE L Q +
Sbjct: 1378 EEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKT 1437
Query: 631 AAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALS 690
+ L R R RL++E +DA D LE+ + + LE K+ + L E + A+
Sbjct: 1438 ETVDRLERGRRRLQQELDDATMD-------LEQQRQLVSTLEKKQRKFDQLLAEEKAAVL 1490
Query: 691 RATLQRDMLQAEKAE-------VAEALTKAEAGRVELELSMTKLRAE-EASLQD------ 736
RA +R+ +AE E + AL + + R ELE LRAE EA L
Sbjct: 1491 RAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGK 1550
Query: 737 SLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLE 796
S+ +L Q DL V +LE+E +A + + + E + + ER + R E
Sbjct: 1551 SVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDE 1610
Query: 797 Q-EVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARR 855
E R+ L LR AE ++ +Q R +L+ +L +L Q++ Q E+A +
Sbjct: 1611 AGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVK 1670
Query: 856 EAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFE 915
+ ++ ++ RE E + Q +E+ + L E RL+ E A + + +
Sbjct: 1671 QLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQ 1730
Query: 916 VQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQ 975
Q+ ++ A+L K L G L L +++ Q + L + + L+Q
Sbjct: 1731 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1790
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAE- 1034
E SL + +A R A+ + QL+R+ +EL RL E
Sbjct: 1791 VE-----SLTTELSAE---------------RSFSAKAESGRQQLERQIQELRGRLGEED 1830
Query: 1035 ---KEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLM-GTRHSLATISL 1090
+ IAAL+ + LA++E+Q +E+ + LS KL+ L + L
Sbjct: 1831 AGARARHKMTIAALESK------LAQAEEQLE---QETRERILSGKLVRRAEKRLKEVVL 1881
Query: 1091 EMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRD 1150
++E ++R A ++Q + R L EEA+ A A RRLQ + D+ + +
Sbjct: 1882 QVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGR-RRLQRELEDVTESAE 1940
Query: 1151 SCLREAEELRTQLR 1164
S RE LR +LR
Sbjct: 1941 SMNREVTTLRNRLR 1954
Score = 180 bits (456), Expect = 1e-44
Identities = 266/1085 (24%), Positives = 458/1085 (42%), Gaps = 148/1085 (13%)
Query: 973 LVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLE 1032
L+Q R Q + + RA + +Q LQ++ EL+ AQL+ + R E+L A E
Sbjct: 869 LLQVTR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAE 926
Query: 1033 --AEKEELSEEIAALQQERDEGLLLAE-----SEKQQALSLKESEKTALSEKLMGTRHSL 1085
AE EE +AA +QE + L+++E E+++ ++EK L + + L
Sbjct: 927 LCAEAEETRGRLAARKQELE--LVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHL 984
Query: 1086 -----ATISLEMERQKRDAQSRQ-EQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQ 1139
A L++E+ +A+ ++ E+D + S+L R E+ A + + +
Sbjct: 985 EAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE 1044
Query: 1140 EQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAG 1199
E+ + L K R ++ +LR E R L + + E QE Q+Q A
Sbjct: 1045 EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAE 1104
Query: 1200 ELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGK 1259
ELR LG R EEL++A+ +AE E + Q L L EA+ A+ +
Sbjct: 1105 ELRAQLG----------RKEEELQAALARAEDE-------GGARAQLLKSLREAQAALAE 1147
Query: 1260 EAGEL---RTGLQEVERSRLEARRELQELRRQMK-MLDSENTRLGRELAELQGRLALGER 1315
+L R + E+ R + EL+ LR +++ LDS N + Q L +
Sbjct: 1148 AQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKT 1207
Query: 1316 AEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARG 1375
E+E+R EA+++ +RQ A +L EQ + RR G+ E+ R
Sbjct: 1208 LEEETRIH-----------EAAVQELRQRHGQALGELAEQ----LEQARRGKGAWEKTRL 1252
Query: 1376 TEKQQLDHARGLELKLEAARAEAAE----LGLRLSAAEGRAQGLEAELARVEVQRRAAEA 1431
+ ++ R L+ AR E + L L+L +GRA E A + + A+A
Sbjct: 1253 ALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQA 1312
Query: 1432 QLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSP 1491
+L + AL A S R + +A + E L + + + GS+ +
Sbjct: 1313 ELENVSGALNE------AESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM 1366
Query: 1492 GPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATS 1551
EA LRE L+E +A RER R+L +A+
Sbjct: 1367 -------------EAEAAGLREQLEE-EAAARER---------AGRELQTAQAQLSEWRR 1403
Query: 1552 RARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERR--------ATLDQ-- 1601
R + A+ EEARR + LA + E+V R ER RR AT+D
Sbjct: 1404 RQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQ 1463
Query: 1602 ----VATLERSLQATESELRASQEKISKMKANETK----LEGDKRR-----LKEVLDASE 1648
V+TLE+ + + L ++EK + ++A E + EG +R L L+ +
Sbjct: 1464 QRQLVSTLEKKQRKFDQLL--AEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQ 1521
Query: 1649 SRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVE 1708
+LE Q R+L EL+ LS ++ +++ + L+R +E A L+ V
Sbjct: 1522 EAREELERQNRALRAELEAL---LSSKDDVGKSVHE----LERACRVAEQAANDLRAQVT 1574
Query: 1709 RLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQE 1768
L L E+++ L V+ L RD LQ A E R+ L +
Sbjct: 1575 ELEDELTAAEDAKLRLEVTVQAL---------KTQHERD----LQGRDEAGEERRRQLAK 1621
Query: 1769 RLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEA----EGQLQQLREVLRQRQE 1824
+L A E RKQ + + L GE+ +L+ Q A E ++QLR++ Q +E
Sbjct: 1622 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE 1681
Query: 1825 --GEAAALNTV-QKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRT 1881
E T +++ + R ++RL L+ + +L+ E +R+ + ++DR +
Sbjct: 1682 LWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADE 1741
Query: 1882 LDKVEREKLRSHEDTVRLSAEKGRLDRTL----TGAELELAEAQRQIQQLEAQVVVLEQS 1937
+ K E+ +L G+L+ L + +EL ++ + Q+E+ L
Sbjct: 1742 VANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE 1801
Query: 1938 HSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQL 1997
S A+ + +L+++++ LR + + AR H+ + LE +++ + QL
Sbjct: 1802 RS---FSAKAESGRQQLERQIQELRGRLGEEDAGARAR---HKMTIAALESKLAQAEEQL 1855
Query: 1998 QQELR 2002
+QE R
Sbjct: 1856 EQETR 1860
Score = 82.8 bits (203), Expect = 3e-15
Identities = 119/487 (24%), Positives = 201/487 (41%), Gaps = 67/487 (13%)
Query: 1539 LAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEE-----SVRRSER 1593
LA++E ERD + +A A ARR+ R A +Q +R +
Sbjct: 800 LAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQW 859
Query: 1594 ERRAT----LDQVATLERSLQATESELRASQE-------KISKMKANETKLEGDKRRLKE 1642
R T L QV + LQA EL+ QE ++ +++ +LE ++ RL E
Sbjct: 860 WRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAE 919
Query: 1643 VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGT 1702
L A + E R L Q L +S+ EA+ ++ +Q + +
Sbjct: 920 QLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQE 979
Query: 1703 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHD 1762
L+ +E GA K++ + K++ E L D+N L K +
Sbjct: 980 LEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLL-------LEDQNSKLSK-------E 1025
Query: 1763 RQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQR 1822
R++L++RL +E ++ SL + +AD+E R+ E + +Q E L++R
Sbjct: 1026 RKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADME-DRLRKEEKGRQELEKLKRR 1084
Query: 1823 QEGEAAALNTVQKLQDER-RLLQERLG----SLQRALAQLEAEKREVERSALRLEKDRVA 1877
+GE++ L Q +R L+ +LG LQ ALA+ E E + L + + A
Sbjct: 1085 LDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAA 1144
Query: 1878 LRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQS 1937
L + +E E++ R AEK R D G ELE + LE +
Sbjct: 1145 LAEAQEDLESERV------ARTKAEKQRRD---LGEELEALRGE------------LEDT 1183
Query: 1938 HSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQL 1997
L+ QQ+L ++E E + ++TLE R H V+ L ++ G+L
Sbjct: 1184 -----LDSTNAQQELRSKREQE-----VTELKKTLEEETRIHEAAVQELRQRHGQALGEL 1233
Query: 1998 QQELRRS 2004
++L ++
Sbjct: 1234 AEQLEQA 1240
Score = 73.2 bits (178), Expect = 2e-12
Identities = 85/347 (24%), Positives = 153/347 (44%), Gaps = 53/347 (15%)
Query: 1676 EAQAQALQDRVDSLQRQVADS--EVKAGTLQLTVERLNGA---------LAKVEESEGAL 1724
+A+AQ LQ +V LQ+Q A E++ QL ER A A+ EE+ G L
Sbjct: 880 QARAQELQ-KVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRL 938
Query: 1725 RDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQS 1784
+ + L +++ A + + + +Q + Q L+ L+A A +
Sbjct: 939 AARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQK----- 993
Query: 1785 SSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQ 1844
L+L++V E ++++ E L ++ + KL ER+LL+
Sbjct: 994 ----------------LQLEKVTTEAKMKKFEEDLLLLEDQNS-------KLSKERKLLE 1030
Query: 1845 ERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKG 1904
+R LA+ ++ E E L K R+ T+ +E + + L K
Sbjct: 1031 DR-------LAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKR 1083
Query: 1905 RLDRTLTGAELELAEAQRQIQQLEAQV----VVLEQSHSPAQLEVDAQQQQLELQQEVE- 1959
RLD + + ++ E Q++ ++L AQ+ L+ + + A+ E A+ Q L+ +E +
Sbjct: 1084 RLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQA 1143
Query: 1960 RLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSA 2006
L AQ E AR +A +QR R L E++ L+G+L+ L ++A
Sbjct: 1144 ALAEAQEDLESERVARTKAEKQR-RDLGEELEALRGELEDTLDSTNA 1189
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 209 bits (531), Expect = 3e-53
Identities = 328/1273 (25%), Positives = 540/1273 (42%), Gaps = 212/1273 (16%)
Query: 757 RLVAQLEEEKSALQGRQRQAEQEATVAREEQERL-EELRLEQEVARQGLEGSLRVAEQAQ 815
R + ++++SAL+ QR + + RL +++ +V RQ R A++ Q
Sbjct: 821 RAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQAR-AQELQ 879
Query: 816 EALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALER----AAREK 871
+ E Q + R E +LQ ++AQL + R + EQ R EA+ EA E AAR++
Sbjct: 880 KVQELQQQSAR-EVGELQGRVAQLEEE---RARLAEQLRAEAELCAEAEETRGRLAARKQ 935
Query: 872 EALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLE 931
E ++LV +E E R EE +++ E +Q+ + +LEA E E
Sbjct: 936 E----------LELVVSELEARVGEEEECSRQMQTEKKR-----LQQHIQELEAHLEAEE 980
Query: 932 AEGQALLLAKETLTGELAGLRQQIIATQE---KASLDKELMAQKLVQAEREAQASLREQR 988
Q L L K T ++ + ++ ++ K S +++L+ +L AE +QA+ E++
Sbjct: 981 GARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL--AEFSSQAAEEEEK 1038
Query: 989 AAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQE 1048
+ L +L+ + EA ++E +R + + + ++E E+L RL+ E EL E++ QQ
Sbjct: 1039 V---KSLNKLRLKYEATIADME-DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQR 1094
Query: 1049 RDE---GLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATIS-----LEMERQKRDAQ 1100
+E L E E Q AL+ E E A ++ L R + A ++ LE ER R
Sbjct: 1095 AEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKA 1154
Query: 1101 SRQEQDRST-VNALTSELRD----------LRAQREEAAAA---HAQEVRRLQEQA-RDL 1145
+Q +D + AL EL D LR++RE+ +E R+ E A ++L
Sbjct: 1155 EKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQEL 1214
Query: 1146 GKQRDSCLREAEELRTQLR-----------LLEDARDGLRRELLEAQRKLRESQEGR--- 1191
++ L E E Q R LE LR EL Q +E ++ R
Sbjct: 1215 RQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRL 1274
Query: 1192 EVQRQE----AGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISL----------- 1236
E+Q QE AG+ R+ E A++ + + E + A+ +AES+ I L
Sbjct: 1275 ELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQL 1334
Query: 1237 ----KLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKML 1292
+L E+ KLAL R A+ EA LR L+E +R A RELQ + Q+
Sbjct: 1335 HDAQELLQEETRAKLALGSRVR-AMEAEAAGLREQLEEEAAARERAGRELQTAQAQL--- 1390
Query: 1293 DSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKL 1352
+ R E G L GE A + + RE L QRL + +++ + + + Q++L
Sbjct: 1391 ----SEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQEL 1446
Query: 1353 QEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRA 1412
+ + ++R+L+ +LE+ + Q L + L+ R A G E RA
Sbjct: 1447 DDATMDLE-QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG---REREARA 1502
Query: 1413 QGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGE 1472
L L + R E Q LR+ L L + + V AE +
Sbjct: 1503 LSLTRALEEEQEAREELERQNRALRAELE---ALLSSKDDVGKSVHELERACRVAEQAAN 1559
Query: 1473 GLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALR-EFLQELRSAQRERDELRTQ 1531
L + T T+ L E AL+ + ++L+ +E R Q
Sbjct: 1560 DLRAQVT---------ELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQ 1610
Query: 1532 TSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRS 1591
L +QL + E ERD +Q AVA AR+ ++G L ++A++A + +
Sbjct: 1611 ---LAKQLRDAEVERD---EERKQRTLAVA----ARKKLEGELEELKAQMASAGQGKEEA 1660
Query: 1592 ERERRATLDQVATLERSLQATESELRASQEKI-SKMKANETKLEGDKRRLKEVLDASESR 1650
++ R Q+ L R ++ E R S+E+I S+ + +E +L+G
Sbjct: 1661 VKQLRKMQAQMKELWREVE----ETRTSREEIFSQNRESEKRLKG--------------- 1701
Query: 1651 TVKLELQRRSLEGELQR--SRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVE 1708
LE E+ R L SDR A+ QA QDR D + +VA+ + +
Sbjct: 1702 ----------LEAEVLRLQEELAASDR-ARRQAQQDR-DEMADEVANGNLSKAAILEEKR 1749
Query: 1709 RLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQE 1768
+L G L ++EE L E QS++ L + R + L LQ + L
Sbjct: 1750 QLEGRLGQLEEE----------LEE--EQSNSELLNDRYRKLLLQV---------ESLTT 1788
Query: 1769 RLDAARQALSEARKQSSSLGEQVQTLRGE---------------VADLELQRVEAEGQL- 1812
L A R ++A L Q+Q LRG +A LE + +AE QL
Sbjct: 1789 ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLE 1848
Query: 1813 QQLREVL---RQRQEGEAAALNTVQKLQDERRLLQERLGSLQRA---LAQLEAEKREVER 1866
Q+ RE + + + E V ++++ERR+ + L++ + QL+ + E E
Sbjct: 1849 QETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEE 1908
Query: 1867 SALRLEKDRVALRRTLDKV--EREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQI 1924
A R + R L+R L+ V E + T+R +G L T RQ+
Sbjct: 1909 EASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFT--------TRTVRQV 1960
Query: 1925 QQLEAQVVVLEQS 1937
+LE V E++
Sbjct: 1961 FRLEEGVASDEEA 1973
Score = 189 bits (481), Expect = 2e-47
Identities = 260/1069 (24%), Positives = 454/1069 (42%), Gaps = 141/1069 (13%)
Query: 530 KRQLQ--VQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKT---------- 577
K++LQ +Q++ EA + L+ + +E++ + EE L L D+
Sbjct: 962 KKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLL 1021
Query: 578 -DGAMQAHEDAQREVQRLRSANELLSREKSNLAHS---LQVAQQQAEELRQEREKLQAAQ 633
D + A E ++++S N+L + ++ +A L+ ++ +EL + + +L
Sbjct: 1022 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1081
Query: 634 EELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRAT 693
EL+ Q ++ E+ R EL+ + + E G R+ L K L E + AL+ A
Sbjct: 1082 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEA- 1140
Query: 694 LQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKL 753
++ L++E+ A TKAE R +L + LR E L+D+L +A E ++ +
Sbjct: 1141 --QEDLESERV----ARTKAEKQRRDLGEELEALRGE---LEDTLDSTNAQQELRSKREQ 1191
Query: 754 DLNRLVAQLEEE----KSALQG-RQRQAEQEATVARE-EQERL-----EELRLEQEVARQ 802
++ L LEEE ++A+Q RQR + +A + EQ R E+ RL E
Sbjct: 1192 EVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVS 1251
Query: 803 GLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVE 862
L L + A++ EQ+ L + ++Q + R + ++L++A+ E +
Sbjct: 1252 ELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSG 1311
Query: 863 ALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRL----EKEALEGSLFEVQR 918
AL A + L+KE + QL + + L +E TR +L A+E ++
Sbjct: 1312 ALNEAESKTIRLSKELSSTEAQL----HDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1367
Query: 919 QLAQLEARREQLEAE---GQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQ 975
QL + A RE+ E QA L E AG + + +A+ + E + Q+L +
Sbjct: 1368 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAE 1427
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQ---EELLARLE 1032
R +R RLQ+E + A +LE +R QL S L+++Q ++LLA +
Sbjct: 1428 KTETVDRLERGRR--------RLQQELDDATMDLEQQR-QLVSTLEKKQRKFDQLLAEEK 1478
Query: 1033 A------EKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALS---EKLMGTRH 1083
A E+ E +E ++ R L A E+Q+A E + AL E L+ ++
Sbjct: 1479 AAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKD 1538
Query: 1084 SLATISLEMERQKRDAQSRQEQDRSTVNALTSEL---RDLRAQREEAAAA-HAQEVRRLQ 1139
+ E+ER R A+ R+ V L EL D + + E A Q R LQ
Sbjct: 1539 DVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQ 1598
Query: 1140 -------EQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGRE 1192
E+ R L KQ E +E R Q L AR L EL E + ++ + +G+E
Sbjct: 1599 GRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKE 1658
Query: 1193 VQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESE---------RISLKLANEDK 1243
++ +++ + E +E E R S EE+ S +++E R+ +LA D+
Sbjct: 1659 EAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDR 1718
Query: 1244 EQ--------------------KLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQ 1283
+ K A+LEE R G+ G+L L+E + + +
Sbjct: 1719 ARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGR-LGQLEEELEEEQSNSELLNDRYR 1777
Query: 1284 ELRRQMKMLDSE--------------NTRLGRELAELQGRLALGERAEKESRRETL-GLR 1328
+L Q++ L +E +L R++ EL+GRL + + + T+ L
Sbjct: 1778 KLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALE 1837
Query: 1329 QRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLE 1388
+L + E LE +E ++ + ++ E R + ++ +EE R Q D
Sbjct: 1838 SKLAQAEEQLEQETRERILSGKLVRRAE----KRLKEVVLQVEEERRVADQLRDQLEKGN 1893
Query: 1389 LKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGR 1448
L+++ + + E S A+ + L+ EL V + ++ LR+ LRRG
Sbjct: 1894 LRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRG----- 1948
Query: 1449 APSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSP 1497
P+ + EG+ S E + PSP P SP
Sbjct: 1949 -------PLTFTTRTVRQVFRLEEGVASDEEAEEAQPGSGPSPEPEGSP 1990
Score = 182 bits (461), Expect = 4e-45
Identities = 275/1154 (23%), Positives = 482/1154 (41%), Gaps = 123/1154 (10%)
Query: 71 TEMASLLSLQEENQLLQ---QELSRVEDLLAQSRAERDELAIKYNAVSE---RLEQALRL 124
T++ LL + ++++LQ QEL +V++L QS E EL + + E RL + LR
Sbjct: 856 TKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRA 915
Query: 125 EPGEL--ETQEPRG-LVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKIL 181
E EL E +E RG L + EL + E +A + + ++ Q + +L Q +Q
Sbjct: 916 E-AELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQ---- 970
Query: 182 QYKKRCSELEQQLLERSG---ELEQQRLRDTEHSQDLESALIRLEEEQQRSAS------- 231
ELE L G +L+ +++ + E L+ LE++ + +
Sbjct: 971 -------ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLED 1023
Query: 232 -LAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFS 290
LA+ ++ E+ ++ S N+ + + + R RKE + R+ E E
Sbjct: 1024 RLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQ-----ELEKLKRRLD 1078
Query: 291 NEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAE 350
E S L Q+V ++ E++ R +L LAR A E G L E
Sbjct: 1079 GESSELQ---EQMVEQQQRAEELRAQLGRKEEELQAALAR---AEDEGGARAQLLKSLRE 1132
Query: 351 SRAEAA-----LEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARV-TELGL 404
++A A LE + + + + E+Q RD + E + + +++ LD + + ++
Sbjct: 1133 AQAALAEAQEDLESERVARTKAEKQRRD-LGEELEALRGELEDTLDSTNAQQELRSKREQ 1191
Query: 405 AVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAAL--ETEDGEGLQQTLRDLAQAVLS 462
V L+K E+ ++++ ++L L E A + G+G + R +A +S
Sbjct: 1192 EVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVS 1251
Query: 463 DSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSP-----RRGPSPACSD 517
+ + +LS + R L Q R R R+ +R + +
Sbjct: 1252 ELRA--ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENV 1309
Query: 518 SSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKT 577
S L S + ++ + +Q+LL + S RA+E + LR++
Sbjct: 1310 SGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQL 1369
Query: 578 DGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQV-------AQQQAEELRQEREKLQ 630
+ A E A RE+Q ++ R + A +L+ A ++AE L Q +
Sbjct: 1370 EEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKT 1429
Query: 631 AAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALS 690
+ L R R RL++E +DA D LE+ + + LE K+ + L E + A+
Sbjct: 1430 ETVDRLERGRRRLQQELDDATMD-------LEQQRQLVSTLEKKQRKFDQLLAEEKAAVL 1482
Query: 691 RATLQRDMLQAEKAE-------VAEALTKAEAGRVELELSMTKLRAE-EASLQD------ 736
RA +R+ +AE E + AL + + R ELE LRAE EA L
Sbjct: 1483 RAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGK 1542
Query: 737 SLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLE 796
S+ +L Q DL V +LE+E +A + + + E + + ER + R E
Sbjct: 1543 SVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDE 1602
Query: 797 Q-EVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARR 855
E R+ L LR AE ++ +Q R +L+ +L +L Q++ Q E+A +
Sbjct: 1603 AGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVK 1662
Query: 856 EAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFE 915
+ ++ ++ RE E + Q +E+ + L E RL+ E A + + +
Sbjct: 1663 QLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQ 1722
Query: 916 VQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQ 975
Q+ ++ A+L K L G L L +++ Q + L + + L+Q
Sbjct: 1723 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1782
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAE- 1034
E SL + +A R A+ + QL+R+ +EL RL E
Sbjct: 1783 VE-----SLTTELSAE---------------RSFSAKAESGRQQLERQIQELRGRLGEED 1822
Query: 1035 ---KEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLM-GTRHSLATISL 1090
+ IAAL+ + LA++E+Q +E+ + LS KL+ L + L
Sbjct: 1823 AGARARHKMTIAALESK------LAQAEEQLE---QETRERILSGKLVRRAEKRLKEVVL 1873
Query: 1091 EMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRD 1150
++E ++R A ++Q + R L EEA+ A A RRLQ + D+ + +
Sbjct: 1874 QVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGR-RRLQRELEDVTESAE 1932
Query: 1151 SCLREAEELRTQLR 1164
S RE LR +LR
Sbjct: 1933 SMNREVTTLRNRLR 1946
Score = 180 bits (456), Expect = 1e-44
Identities = 266/1085 (24%), Positives = 458/1085 (42%), Gaps = 148/1085 (13%)
Query: 973 LVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLE 1032
L+Q R Q + + RA + +Q LQ++ EL+ AQL+ + R E+L A E
Sbjct: 861 LLQVTR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAE 918
Query: 1033 --AEKEELSEEIAALQQERDEGLLLAE-----SEKQQALSLKESEKTALSEKLMGTRHSL 1085
AE EE +AA +QE + L+++E E+++ ++EK L + + L
Sbjct: 919 LCAEAEETRGRLAARKQELE--LVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHL 976
Query: 1086 -----ATISLEMERQKRDAQSRQ-EQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQ 1139
A L++E+ +A+ ++ E+D + S+L R E+ A + + +
Sbjct: 977 EAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE 1036
Query: 1140 EQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAG 1199
E+ + L K R ++ +LR E R L + + E QE Q+Q A
Sbjct: 1037 EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAE 1096
Query: 1200 ELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGK 1259
ELR LG R EEL++A+ +AE E + Q L L EA+ A+ +
Sbjct: 1097 ELRAQLG----------RKEEELQAALARAEDE-------GGARAQLLKSLREAQAALAE 1139
Query: 1260 EAGEL---RTGLQEVERSRLEARRELQELRRQMK-MLDSENTRLGRELAELQGRLALGER 1315
+L R + E+ R + EL+ LR +++ LDS N + Q L +
Sbjct: 1140 AQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKT 1199
Query: 1316 AEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARG 1375
E+E+R EA+++ +RQ A +L EQ + RR G+ E+ R
Sbjct: 1200 LEEETRIH-----------EAAVQELRQRHGQALGELAEQ----LEQARRGKGAWEKTRL 1244
Query: 1376 TEKQQLDHARGLELKLEAARAEAAE----LGLRLSAAEGRAQGLEAELARVEVQRRAAEA 1431
+ ++ R L+ AR E + L L+L +GRA E A + + A+A
Sbjct: 1245 ALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQA 1304
Query: 1432 QLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSP 1491
+L + AL A S R + +A + E L + + + GS+ +
Sbjct: 1305 ELENVSGALNE------AESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM 1358
Query: 1492 GPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATS 1551
EA LRE L+E +A RER R+L +A+
Sbjct: 1359 -------------EAEAAGLREQLEE-EAAARER---------AGRELQTAQAQLSEWRR 1395
Query: 1552 RARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERR--------ATLDQ-- 1601
R + A+ EEARR + LA + E+V R ER RR AT+D
Sbjct: 1396 RQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQ 1455
Query: 1602 ----VATLERSLQATESELRASQEKISKMKANETK----LEGDKRR-----LKEVLDASE 1648
V+TLE+ + + L ++EK + ++A E + EG +R L L+ +
Sbjct: 1456 QRQLVSTLEKKQRKFDQLL--AEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQ 1513
Query: 1649 SRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVE 1708
+LE Q R+L EL+ LS ++ +++ + L+R +E A L+ V
Sbjct: 1514 EAREELERQNRALRAELEAL---LSSKDDVGKSVHE----LERACRVAEQAANDLRAQVT 1566
Query: 1709 RLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQE 1768
L L E+++ L V+ L RD LQ A E R+ L +
Sbjct: 1567 ELEDELTAAEDAKLRLEVTVQAL---------KTQHERD----LQGRDEAGEERRRQLAK 1613
Query: 1769 RLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEA----EGQLQQLREVLRQRQE 1824
+L A E RKQ + + L GE+ +L+ Q A E ++QLR++ Q +E
Sbjct: 1614 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE 1673
Query: 1825 --GEAAALNTV-QKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRT 1881
E T +++ + R ++RL L+ + +L+ E +R+ + ++DR +
Sbjct: 1674 LWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADE 1733
Query: 1882 LDKVEREKLRSHEDTVRLSAEKGRLDRTL----TGAELELAEAQRQIQQLEAQVVVLEQS 1937
+ K E+ +L G+L+ L + +EL ++ + Q+E+ L
Sbjct: 1734 VANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE 1793
Query: 1938 HSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQL 1997
S A+ + +L+++++ LR + + AR H+ + LE +++ + QL
Sbjct: 1794 RS---FSAKAESGRQQLERQIQELRGRLGEEDAGARAR---HKMTIAALESKLAQAEEQL 1847
Query: 1998 QQELR 2002
+QE R
Sbjct: 1848 EQETR 1852
Score = 82.8 bits (203), Expect = 3e-15
Identities = 119/487 (24%), Positives = 201/487 (41%), Gaps = 67/487 (13%)
Query: 1539 LAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEE-----SVRRSER 1593
LA++E ERD + +A A ARR+ R A +Q +R +
Sbjct: 792 LAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQW 851
Query: 1594 ERRAT----LDQVATLERSLQATESELRASQE-------KISKMKANETKLEGDKRRLKE 1642
R T L QV + LQA EL+ QE ++ +++ +LE ++ RL E
Sbjct: 852 WRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAE 911
Query: 1643 VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGT 1702
L A + E R L Q L +S+ EA+ ++ +Q + +
Sbjct: 912 QLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQE 971
Query: 1703 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHD 1762
L+ +E GA K++ + K++ E L D+N L K +
Sbjct: 972 LEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLL-------LEDQNSKLSK-------E 1017
Query: 1763 RQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQR 1822
R++L++RL +E ++ SL + +AD+E R+ E + +Q E L++R
Sbjct: 1018 RKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADME-DRLRKEEKGRQELEKLKRR 1076
Query: 1823 QEGEAAALNTVQKLQDER-RLLQERLG----SLQRALAQLEAEKREVERSALRLEKDRVA 1877
+GE++ L Q +R L+ +LG LQ ALA+ E E + L + + A
Sbjct: 1077 LDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAA 1136
Query: 1878 LRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQS 1937
L + +E E++ R AEK R D G ELE + LE +
Sbjct: 1137 LAEAQEDLESERV------ARTKAEKQRRD---LGEELEALRGE------------LEDT 1175
Query: 1938 HSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQL 1997
L+ QQ+L ++E E + ++TLE R H V+ L ++ G+L
Sbjct: 1176 -----LDSTNAQQELRSKREQE-----VTELKKTLEEETRIHEAAVQELRQRHGQALGEL 1225
Query: 1998 QQELRRS 2004
++L ++
Sbjct: 1226 AEQLEQA 1232
Score = 73.2 bits (178), Expect = 2e-12
Identities = 85/347 (24%), Positives = 153/347 (44%), Gaps = 53/347 (15%)
Query: 1676 EAQAQALQDRVDSLQRQVADS--EVKAGTLQLTVERLNGA---------LAKVEESEGAL 1724
+A+AQ LQ +V LQ+Q A E++ QL ER A A+ EE+ G L
Sbjct: 872 QARAQELQ-KVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRL 930
Query: 1725 RDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQS 1784
+ + L +++ A + + + +Q + Q L+ L+A A +
Sbjct: 931 AARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQK----- 985
Query: 1785 SSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQ 1844
L+L++V E ++++ E L ++ + KL ER+LL+
Sbjct: 986 ----------------LQLEKVTTEAKMKKFEEDLLLLEDQNS-------KLSKERKLLE 1022
Query: 1845 ERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKG 1904
+R LA+ ++ E E L K R+ T+ +E + + L K
Sbjct: 1023 DR-------LAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKR 1075
Query: 1905 RLDRTLTGAELELAEAQRQIQQLEAQV----VVLEQSHSPAQLEVDAQQQQLELQQEVE- 1959
RLD + + ++ E Q++ ++L AQ+ L+ + + A+ E A+ Q L+ +E +
Sbjct: 1076 RLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQA 1135
Query: 1960 RLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSA 2006
L AQ E AR +A +QR R L E++ L+G+L+ L ++A
Sbjct: 1136 ALAEAQEDLESERVARTKAEKQR-RDLGEELEALRGELEDTLDSTNA 1181
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 209 bits (531), Expect = 3e-53
Identities = 328/1273 (25%), Positives = 540/1273 (42%), Gaps = 212/1273 (16%)
Query: 757 RLVAQLEEEKSALQGRQRQAEQEATVAREEQERL-EELRLEQEVARQGLEGSLRVAEQAQ 815
R + ++++SAL+ QR + + RL +++ +V RQ R A++ Q
Sbjct: 862 RAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQAR-AQELQ 920
Query: 816 EALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALER----AAREK 871
+ E Q + R E +LQ ++AQL + R + EQ R EA+ EA E AAR++
Sbjct: 921 KVQELQQQSAR-EVGELQGRVAQLEEE---RARLAEQLRAEAELCAEAEETRGRLAARKQ 976
Query: 872 EALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLE 931
E ++LV +E E R EE +++ E +Q+ + +LEA E E
Sbjct: 977 E----------LELVVSELEARVGEEEECSRQMQTEKKR-----LQQHIQELEAHLEAEE 1021
Query: 932 AEGQALLLAKETLTGELAGLRQQIIATQE---KASLDKELMAQKLVQAEREAQASLREQR 988
Q L L K T ++ + ++ ++ K S +++L+ +L AE +QA+ E++
Sbjct: 1022 GARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL--AEFSSQAAEEEEK 1079
Query: 989 AAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQE 1048
+ L +L+ + EA ++E +R + + + ++E E+L RL+ E EL E++ QQ
Sbjct: 1080 V---KSLNKLRLKYEATIADME-DRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQR 1135
Query: 1049 RDE---GLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATIS-----LEMERQKRDAQ 1100
+E L E E Q AL+ E E A ++ L R + A ++ LE ER R
Sbjct: 1136 AEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKA 1195
Query: 1101 SRQEQDRST-VNALTSELRD----------LRAQREEAAAA---HAQEVRRLQEQA-RDL 1145
+Q +D + AL EL D LR++RE+ +E R+ E A ++L
Sbjct: 1196 EKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQEL 1255
Query: 1146 GKQRDSCLREAEELRTQLR-----------LLEDARDGLRRELLEAQRKLRESQEGR--- 1191
++ L E E Q R LE LR EL Q +E ++ R
Sbjct: 1256 RQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRL 1315
Query: 1192 EVQRQE----AGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISL----------- 1236
E+Q QE AG+ R+ E A++ + + E + A+ +AES+ I L
Sbjct: 1316 ELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQL 1375
Query: 1237 ----KLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKML 1292
+L E+ KLAL R A+ EA LR L+E +R A RELQ + Q+
Sbjct: 1376 HDAQELLQEETRAKLALGSRVR-AMEAEAAGLREQLEEEAAARERAGRELQTAQAQL--- 1431
Query: 1293 DSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKL 1352
+ R E G L GE A + + RE L QRL + +++ + + + Q++L
Sbjct: 1432 ----SEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQEL 1487
Query: 1353 QEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRA 1412
+ + ++R+L+ +LE+ + Q L + L+ R A G E RA
Sbjct: 1488 DDATMDLE-QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG---REREARA 1543
Query: 1413 QGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGE 1472
L L + R E Q LR+ L L + + V AE +
Sbjct: 1544 LSLTRALEEEQEAREELERQNRALRAELE---ALLSSKDDVGKSVHELERACRVAEQAAN 1600
Query: 1473 GLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALR-EFLQELRSAQRERDELRTQ 1531
L + T T+ L E AL+ + ++L+ +E R Q
Sbjct: 1601 DLRAQVT---------ELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQ 1651
Query: 1532 TSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRS 1591
L +QL + E ERD +Q AVA AR+ ++G L ++A++A + +
Sbjct: 1652 ---LAKQLRDAEVERD---EERKQRTLAVA----ARKKLEGELEELKAQMASAGQGKEEA 1701
Query: 1592 ERERRATLDQVATLERSLQATESELRASQEKI-SKMKANETKLEGDKRRLKEVLDASESR 1650
++ R Q+ L R ++ E R S+E+I S+ + +E +L+G
Sbjct: 1702 VKQLRKMQAQMKELWREVE----ETRTSREEIFSQNRESEKRLKG--------------- 1742
Query: 1651 TVKLELQRRSLEGELQR--SRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVE 1708
LE E+ R L SDR A+ QA QDR D + +VA+ + +
Sbjct: 1743 ----------LEAEVLRLQEELAASDR-ARRQAQQDR-DEMADEVANGNLSKAAILEEKR 1790
Query: 1709 RLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQE 1768
+L G L ++EE L E QS++ L + R + L LQ + L
Sbjct: 1791 QLEGRLGQLEEE----------LEE--EQSNSELLNDRYRKLLLQV---------ESLTT 1829
Query: 1769 RLDAARQALSEARKQSSSLGEQVQTLRGE---------------VADLELQRVEAEGQL- 1812
L A R ++A L Q+Q LRG +A LE + +AE QL
Sbjct: 1830 ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLE 1889
Query: 1813 QQLREVL---RQRQEGEAAALNTVQKLQDERRLLQERLGSLQRA---LAQLEAEKREVER 1866
Q+ RE + + + E V ++++ERR+ + L++ + QL+ + E E
Sbjct: 1890 QETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEE 1949
Query: 1867 SALRLEKDRVALRRTLDKV--EREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQI 1924
A R + R L+R L+ V E + T+R +G L T RQ+
Sbjct: 1950 EASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFT--------TRTVRQV 2001
Query: 1925 QQLEAQVVVLEQS 1937
+LE V E++
Sbjct: 2002 FRLEEGVASDEEA 2014
Score = 189 bits (481), Expect = 2e-47
Identities = 260/1069 (24%), Positives = 454/1069 (42%), Gaps = 141/1069 (13%)
Query: 530 KRQLQ--VQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKT---------- 577
K++LQ +Q++ EA + L+ + +E++ + EE L L D+
Sbjct: 1003 KKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLL 1062
Query: 578 -DGAMQAHEDAQREVQRLRSANELLSREKSNLAHS---LQVAQQQAEELRQEREKLQAAQ 633
D + A E ++++S N+L + ++ +A L+ ++ +EL + + +L
Sbjct: 1063 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1122
Query: 634 EELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRAT 693
EL+ Q ++ E+ R EL+ + + E G R+ L K L E + AL+ A
Sbjct: 1123 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEA- 1181
Query: 694 LQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKL 753
++ L++E+ A TKAE R +L + LR E L+D+L +A E ++ +
Sbjct: 1182 --QEDLESERV----ARTKAEKQRRDLGEELEALRGE---LEDTLDSTNAQQELRSKREQ 1232
Query: 754 DLNRLVAQLEEE----KSALQG-RQRQAEQEATVARE-EQERL-----EELRLEQEVARQ 802
++ L LEEE ++A+Q RQR + +A + EQ R E+ RL E
Sbjct: 1233 EVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVS 1292
Query: 803 GLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVE 862
L L + A++ EQ+ L + ++Q + R + ++L++A+ E +
Sbjct: 1293 ELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSG 1352
Query: 863 ALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRL----EKEALEGSLFEVQR 918
AL A + L+KE + QL + + L +E TR +L A+E ++
Sbjct: 1353 ALNEAESKTIRLSKELSSTEAQL----HDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1408
Query: 919 QLAQLEARREQLEAE---GQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQ 975
QL + A RE+ E QA L E AG + + +A+ + E + Q+L +
Sbjct: 1409 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAE 1468
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQ---EELLARLE 1032
R +R RLQ+E + A +LE +R QL S L+++Q ++LLA +
Sbjct: 1469 KTETVDRLERGRR--------RLQQELDDATMDLEQQR-QLVSTLEKKQRKFDQLLAEEK 1519
Query: 1033 A------EKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALS---EKLMGTRH 1083
A E+ E +E ++ R L A E+Q+A E + AL E L+ ++
Sbjct: 1520 AAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKD 1579
Query: 1084 SLATISLEMERQKRDAQSRQEQDRSTVNALTSEL---RDLRAQREEAAAA-HAQEVRRLQ 1139
+ E+ER R A+ R+ V L EL D + + E A Q R LQ
Sbjct: 1580 DVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQ 1639
Query: 1140 -------EQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGRE 1192
E+ R L KQ E +E R Q L AR L EL E + ++ + +G+E
Sbjct: 1640 GRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKE 1699
Query: 1193 VQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESE---------RISLKLANEDK 1243
++ +++ + E +E E R S EE+ S +++E R+ +LA D+
Sbjct: 1700 EAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDR 1759
Query: 1244 EQ--------------------KLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQ 1283
+ K A+LEE R G+ G+L L+E + + +
Sbjct: 1760 ARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGR-LGQLEEELEEEQSNSELLNDRYR 1818
Query: 1284 ELRRQMKMLDSE--------------NTRLGRELAELQGRLALGERAEKESRRETL-GLR 1328
+L Q++ L +E +L R++ EL+GRL + + + T+ L
Sbjct: 1819 KLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALE 1878
Query: 1329 QRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLE 1388
+L + E LE +E ++ + ++ E R + ++ +EE R Q D
Sbjct: 1879 SKLAQAEEQLEQETRERILSGKLVRRAE----KRLKEVVLQVEEERRVADQLRDQLEKGN 1934
Query: 1389 LKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGR 1448
L+++ + + E S A+ + L+ EL V + ++ LR+ LRRG
Sbjct: 1935 LRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRG----- 1989
Query: 1449 APSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSP 1497
P+ + EG+ S E + PSP P SP
Sbjct: 1990 -------PLTFTTRTVRQVFRLEEGVASDEEAEEAQPGSGPSPEPEGSP 2031
Score = 182 bits (461), Expect = 4e-45
Identities = 275/1154 (23%), Positives = 482/1154 (41%), Gaps = 123/1154 (10%)
Query: 71 TEMASLLSLQEENQLLQ---QELSRVEDLLAQSRAERDELAIKYNAVSE---RLEQALRL 124
T++ LL + ++++LQ QEL +V++L QS E EL + + E RL + LR
Sbjct: 897 TKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRA 956
Query: 125 EPGEL--ETQEPRG-LVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKIL 181
E EL E +E RG L + EL + E +A + + ++ Q + +L Q +Q
Sbjct: 957 E-AELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQ---- 1011
Query: 182 QYKKRCSELEQQLLERSG---ELEQQRLRDTEHSQDLESALIRLEEEQQRSAS------- 231
ELE L G +L+ +++ + E L+ LE++ + +
Sbjct: 1012 -------ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLED 1064
Query: 232 -LAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFS 290
LA+ ++ E+ ++ S N+ + + + R RKE + R+ E E
Sbjct: 1065 RLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQ-----ELEKLKRRLD 1119
Query: 291 NEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAE 350
E S L Q+V ++ E++ R +L LAR A E G L E
Sbjct: 1120 GESSELQ---EQMVEQQQRAEELRAQLGRKEEELQAALAR---AEDEGGARAQLLKSLRE 1173
Query: 351 SRAEAA-----LEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARV-TELGL 404
++A A LE + + + + E+Q RD + E + + +++ LD + + ++
Sbjct: 1174 AQAALAEAQEDLESERVARTKAEKQRRD-LGEELEALRGELEDTLDSTNAQQELRSKREQ 1232
Query: 405 AVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAAL--ETEDGEGLQQTLRDLAQAVLS 462
V L+K E+ ++++ ++L L E A + G+G + R +A +S
Sbjct: 1233 EVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVS 1292
Query: 463 DSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSP-----RRGPSPACSD 517
+ + +LS + R L Q R R R+ +R + +
Sbjct: 1293 ELRA--ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENV 1350
Query: 518 SSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKT 577
S L S + ++ + +Q+LL + S RA+E + LR++
Sbjct: 1351 SGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQL 1410
Query: 578 DGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQV-------AQQQAEELRQEREKLQ 630
+ A E A RE+Q ++ R + A +L+ A ++AE L Q +
Sbjct: 1411 EEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKT 1470
Query: 631 AAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALS 690
+ L R R RL++E +DA D LE+ + + LE K+ + L E + A+
Sbjct: 1471 ETVDRLERGRRRLQQELDDATMD-------LEQQRQLVSTLEKKQRKFDQLLAEEKAAVL 1523
Query: 691 RATLQRDMLQAEKAE-------VAEALTKAEAGRVELELSMTKLRAE-EASLQD------ 736
RA +R+ +AE E + AL + + R ELE LRAE EA L
Sbjct: 1524 RAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGK 1583
Query: 737 SLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLE 796
S+ +L Q DL V +LE+E +A + + + E + + ER + R E
Sbjct: 1584 SVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDE 1643
Query: 797 Q-EVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARR 855
E R+ L LR AE ++ +Q R +L+ +L +L Q++ Q E+A +
Sbjct: 1644 AGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVK 1703
Query: 856 EAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFE 915
+ ++ ++ RE E + Q +E+ + L E RL+ E A + + +
Sbjct: 1704 QLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQ 1763
Query: 916 VQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQ 975
Q+ ++ A+L K L G L L +++ Q + L + + L+Q
Sbjct: 1764 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1823
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAE- 1034
E SL + +A R A+ + QL+R+ +EL RL E
Sbjct: 1824 VE-----SLTTELSAE---------------RSFSAKAESGRQQLERQIQELRGRLGEED 1863
Query: 1035 ---KEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLM-GTRHSLATISL 1090
+ IAAL+ + LA++E+Q +E+ + LS KL+ L + L
Sbjct: 1864 AGARARHKMTIAALESK------LAQAEEQLE---QETRERILSGKLVRRAEKRLKEVVL 1914
Query: 1091 EMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRD 1150
++E ++R A ++Q + R L EEA+ A A RRLQ + D+ + +
Sbjct: 1915 QVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGR-RRLQRELEDVTESAE 1973
Query: 1151 SCLREAEELRTQLR 1164
S RE LR +LR
Sbjct: 1974 SMNREVTTLRNRLR 1987
Score = 180 bits (456), Expect = 1e-44
Identities = 266/1085 (24%), Positives = 458/1085 (42%), Gaps = 148/1085 (13%)
Query: 973 LVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLE 1032
L+Q R Q + + RA + +Q LQ++ EL+ AQL+ + R E+L A E
Sbjct: 902 LLQVTR--QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAE 959
Query: 1033 --AEKEELSEEIAALQQERDEGLLLAE-----SEKQQALSLKESEKTALSEKLMGTRHSL 1085
AE EE +AA +QE + L+++E E+++ ++EK L + + L
Sbjct: 960 LCAEAEETRGRLAARKQELE--LVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHL 1017
Query: 1086 -----ATISLEMERQKRDAQSRQ-EQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQ 1139
A L++E+ +A+ ++ E+D + S+L R E+ A + + +
Sbjct: 1018 EAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEE 1077
Query: 1140 EQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAG 1199
E+ + L K R ++ +LR E R L + + E QE Q+Q A
Sbjct: 1078 EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAE 1137
Query: 1200 ELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGK 1259
ELR LG R EEL++A+ +AE E + Q L L EA+ A+ +
Sbjct: 1138 ELRAQLG----------RKEEELQAALARAEDE-------GGARAQLLKSLREAQAALAE 1180
Query: 1260 EAGEL---RTGLQEVERSRLEARRELQELRRQMK-MLDSENTRLGRELAELQGRLALGER 1315
+L R + E+ R + EL+ LR +++ LDS N + Q L +
Sbjct: 1181 AQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKT 1240
Query: 1316 AEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARG 1375
E+E+R EA+++ +RQ A +L EQ + RR G+ E+ R
Sbjct: 1241 LEEETRIH-----------EAAVQELRQRHGQALGELAEQ----LEQARRGKGAWEKTRL 1285
Query: 1376 TEKQQLDHARGLELKLEAARAEAAE----LGLRLSAAEGRAQGLEAELARVEVQRRAAEA 1431
+ ++ R L+ AR E + L L+L +GRA E A + + A+A
Sbjct: 1286 ALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQA 1345
Query: 1432 QLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSP 1491
+L + AL A S R + +A + E L + + + GS+ +
Sbjct: 1346 ELENVSGALNE------AESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM 1399
Query: 1492 GPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATS 1551
EA LRE L+E +A RER R+L +A+
Sbjct: 1400 -------------EAEAAGLREQLEE-EAAARER---------AGRELQTAQAQLSEWRR 1436
Query: 1552 RARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERR--------ATLDQ-- 1601
R + A+ EEARR + LA + E+V R ER RR AT+D
Sbjct: 1437 RQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQ 1496
Query: 1602 ----VATLERSLQATESELRASQEKISKMKANETK----LEGDKRR-----LKEVLDASE 1648
V+TLE+ + + L ++EK + ++A E + EG +R L L+ +
Sbjct: 1497 QRQLVSTLEKKQRKFDQLL--AEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQ 1554
Query: 1649 SRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVE 1708
+LE Q R+L EL+ LS ++ +++ + L+R +E A L+ V
Sbjct: 1555 EAREELERQNRALRAELEAL---LSSKDDVGKSVHE----LERACRVAEQAANDLRAQVT 1607
Query: 1709 RLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQE 1768
L L E+++ L V+ L RD LQ A E R+ L +
Sbjct: 1608 ELEDELTAAEDAKLRLEVTVQAL---------KTQHERD----LQGRDEAGEERRRQLAK 1654
Query: 1769 RLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEA----EGQLQQLREVLRQRQE 1824
+L A E RKQ + + L GE+ +L+ Q A E ++QLR++ Q +E
Sbjct: 1655 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE 1714
Query: 1825 --GEAAALNTV-QKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRT 1881
E T +++ + R ++RL L+ + +L+ E +R+ + ++DR +
Sbjct: 1715 LWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADE 1774
Query: 1882 LDKVEREKLRSHEDTVRLSAEKGRLDRTL----TGAELELAEAQRQIQQLEAQVVVLEQS 1937
+ K E+ +L G+L+ L + +EL ++ + Q+E+ L
Sbjct: 1775 VANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE 1834
Query: 1938 HSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQL 1997
S A+ + +L+++++ LR + + AR H+ + LE +++ + QL
Sbjct: 1835 RS---FSAKAESGRQQLERQIQELRGRLGEEDAGARAR---HKMTIAALESKLAQAEEQL 1888
Query: 1998 QQELR 2002
+QE R
Sbjct: 1889 EQETR 1893
Score = 82.8 bits (203), Expect = 3e-15
Identities = 119/487 (24%), Positives = 201/487 (41%), Gaps = 67/487 (13%)
Query: 1539 LAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEE-----SVRRSER 1593
LA++E ERD + +A A ARR+ R A +Q +R +
Sbjct: 833 LAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQW 892
Query: 1594 ERRAT----LDQVATLERSLQATESELRASQE-------KISKMKANETKLEGDKRRLKE 1642
R T L QV + LQA EL+ QE ++ +++ +LE ++ RL E
Sbjct: 893 WRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAE 952
Query: 1643 VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGT 1702
L A + E R L Q L +S+ EA+ ++ +Q + +
Sbjct: 953 QLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQE 1012
Query: 1703 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHD 1762
L+ +E GA K++ + K++ E L D+N L K +
Sbjct: 1013 LEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLL-------LEDQNSKLSK-------E 1058
Query: 1763 RQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQR 1822
R++L++RL +E ++ SL + +AD+E R+ E + +Q E L++R
Sbjct: 1059 RKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADME-DRLRKEEKGRQELEKLKRR 1117
Query: 1823 QEGEAAALNTVQKLQDER-RLLQERLG----SLQRALAQLEAEKREVERSALRLEKDRVA 1877
+GE++ L Q +R L+ +LG LQ ALA+ E E + L + + A
Sbjct: 1118 LDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAA 1177
Query: 1878 LRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQS 1937
L + +E E++ R AEK R D G ELE + LE +
Sbjct: 1178 LAEAQEDLESERV------ARTKAEKQRRD---LGEELEALRGE------------LEDT 1216
Query: 1938 HSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQL 1997
L+ QQ+L ++E E + ++TLE R H V+ L ++ G+L
Sbjct: 1217 -----LDSTNAQQELRSKREQE-----VTELKKTLEEETRIHEAAVQELRQRHGQALGEL 1266
Query: 1998 QQELRRS 2004
++L ++
Sbjct: 1267 AEQLEQA 1273
Score = 73.2 bits (178), Expect = 2e-12
Identities = 85/347 (24%), Positives = 153/347 (44%), Gaps = 53/347 (15%)
Query: 1676 EAQAQALQDRVDSLQRQVADS--EVKAGTLQLTVERLNGA---------LAKVEESEGAL 1724
+A+AQ LQ +V LQ+Q A E++ QL ER A A+ EE+ G L
Sbjct: 913 QARAQELQ-KVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRL 971
Query: 1725 RDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQS 1784
+ + L +++ A + + + +Q + Q L+ L+A A +
Sbjct: 972 AARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQK----- 1026
Query: 1785 SSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQ 1844
L+L++V E ++++ E L ++ + KL ER+LL+
Sbjct: 1027 ----------------LQLEKVTTEAKMKKFEEDLLLLEDQNS-------KLSKERKLLE 1063
Query: 1845 ERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKG 1904
+R LA+ ++ E E L K R+ T+ +E + + L K
Sbjct: 1064 DR-------LAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKR 1116
Query: 1905 RLDRTLTGAELELAEAQRQIQQLEAQV----VVLEQSHSPAQLEVDAQQQQLELQQEVE- 1959
RLD + + ++ E Q++ ++L AQ+ L+ + + A+ E A+ Q L+ +E +
Sbjct: 1117 RLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQA 1176
Query: 1960 RLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSA 2006
L AQ E AR +A +QR R L E++ L+G+L+ L ++A
Sbjct: 1177 ALAEAQEDLESERVARTKAEKQR-RDLGEELEALRGELEDTLDSTNA 1222
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 206 bits (525), Expect = 1e-52
Identities = 285/1338 (21%), Positives = 577/1338 (43%), Gaps = 197/1338 (14%)
Query: 171 QLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRD---TEHSQDLESALIRLEEEQ- 226
Q VQ LQ + + K EL+++L + G +Q+ D T+ S +L+S +LEE Q
Sbjct: 90 QEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQT 149
Query: 227 -------------QRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTR------- 266
Q++A LA A ++ + D+ S +A + + ++T + +
Sbjct: 150 ENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQD 209
Query: 267 CRKELEHRE-----AAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMF----- 316
+ EL R A ++E N + L R+ +L E K
Sbjct: 210 LKTELLQRPGIEDVAVLKKELVQVQTLMDN-----MTLERERES-EKLKDECKKLQSQYA 263
Query: 317 -TERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQ---------AQ 366
+E + QL ELA+ QE + + +L S E + Q L + +
Sbjct: 264 SSEATISQLRSELAK---GPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320
Query: 367 LEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEK 426
LEE+ ++ + +K++ Q DLD L +R++ ++ R+ + EK + + L E+
Sbjct: 321 LEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEE 380
Query: 427 LEALESL---------RLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTA 477
L +E+ +LQ+Q + + G LQ + L +L +ER
Sbjct: 381 LSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLE----------TERQL 430
Query: 478 DASNGSL---RGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQ 534
++G L R LS ++ ++ + + + R +++ L H Q
Sbjct: 431 GEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQH--------Q 482
Query: 535 VQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRL 594
+ + +++ Q L + +L +++++ LE+ L+++ DK Q ++ + +Q+
Sbjct: 483 LDKTKQQHQEQQALQQSTTAKLREAQND---LEQVLRQIGDKD----QKIQNLEALLQKS 535
Query: 595 RSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDG 654
+ LL +E+ +L +Q + + L Q +EK QE++ + ++L+ + E Q
Sbjct: 536 KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595
Query: 655 ARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE 714
+ +++ L + + L + E+ L+ + + L + E L AE
Sbjct: 596 ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAE 655
Query: 715 AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQR 774
A + A+ A LQ+ L +L + +LN++ QL++ + LQ +Q
Sbjct: 656 AAKT----------AQRADLQNHLD---TAQNALQDKQQELNKITTQLDQVTAKLQDKQE 702
Query: 775 QAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAE----QAQEALEQQLPTLRHER- 829
Q + +E +E+ L LEQ+ + LEG ++ E + + + EQ L L+ +R
Sbjct: 703 HCSQLESHLKEYKEKY--LSLEQKT--EELEGQIKKLEADSLEVKASKEQALQDLQQQRQ 758
Query: 830 --SQLQEQLAQLSRQLSGREQELEQARREAQRQVEALE-------RAAREKEALAKEHAG 880
+ L+ + +LS+QL ++ + R + Q++ EALE + EK+ L ++
Sbjct: 759 LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFET 818
Query: 881 LA----VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ----LEARREQLEA 932
L+ +Q +T E ++++EKEAL L V+ +L++ L+ + + E
Sbjct: 819 LSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878
Query: 933 EGQALLLAKETLTGELAGLRQQIIATQE---------KASLDKEL------------MAQ 971
E Q A L L+ Q+ E K SL+KE M +
Sbjct: 879 ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938
Query: 972 KLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARL 1031
+L+QA+ + + +E++ + ++ L++ E +++EA + +L+ + ++ EL +L
Sbjct: 939 QLIQAQNTLKQNEKEEQQL-QGNINELKQSSEQKKKQIEALQGELKIAVL-QKTELENKL 996
Query: 1032 EAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE 1091
+ + + ++E+AA ++E+ L + Q+ +S+ +L+ TR L ++ +
Sbjct: 997 QQQLTQAAQELAA-EKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK 1055
Query: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRD- 1150
+ + D S + Q + N L EL+ +A E+ +A Q+++ + +D+ K++
Sbjct: 1056 LSLAQEDLISNRNQIGNQ-NKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL 1114
Query: 1151 ---------SCLREAEELRT-QLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGE 1200
S L E EE++ Q + + + L+ LE+ +++ ++ +++ Q+ E
Sbjct: 1115 KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE 1174
Query: 1201 LRRSLGEGAKEREALRRSNEELRSAVKKAESE------RISLKLANEDKEQKLALL--EE 1252
L+ E +R+ + L+ VKK E E KL +E KE+++ + EE
Sbjct: 1175 LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEE 1234
Query: 1253 ARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLAL 1312
+ + L L V++ ++R + EL +Q +L+G +A+
Sbjct: 1235 NEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD--------------DLRGEIAV 1280
Query: 1313 GERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEE 1372
E + ++ E L +R LKGE +E ++ ++ QRKL + E
Sbjct: 1281 LEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQ----------EL 1330
Query: 1373 ARGTEKQQLDHARGLELK 1390
R + Q+ H + L K
Sbjct: 1331 GRENQSLQIKHTQALNRK 1348
Score = 181 bits (460), Expect = 5e-45
Identities = 291/1340 (21%), Positives = 572/1340 (42%), Gaps = 137/1340 (10%)
Query: 739 SKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQE 798
S L+ + + + ++ L A L+EEK + +++ E+ + ++E + + L +
Sbjct: 76 SNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKP-DGLVTDSS 134
Query: 799 VARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQ 858
Q LE L A+ ++Q + +QL ++A + + E A ++
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 859 RQVEALERAAREKEALAKE---HAGLAVQLVAAER--EGRTLSEEATRLR-LEKEALEGS 912
R E L + A + L E G+ V + + +TL + T R E E L+
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
Query: 913 LFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIA-TQEKASLDKELMAQ 971
++Q Q A EA QL +E EL L+ + TQ+ +L + L+ +
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314
Query: 972 -----KLVQAEREAQASLRE-QRAAHEEDL--QRLQREKEAAWRELEAERAQLQSQLQRE 1023
KL + E S + Q H++DL Q+LQ A+ L +L + +
Sbjct: 315 EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374
Query: 1024 QE--ELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGT 1081
Q+ E L+ +E + + L E LQQ+R+E ++Q L L +SE L KL
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQREE-------KEQHGLQL-QSEINQLHSKL--- 423
Query: 1082 RHSLATISLEMERQKRDAQSRQEQDRSTVNALTSE-LRDLRAQREEAAAAHAQEVRRLQE 1140
LE ERQ +A R ++ R L+SE L D +E+ A ++ RL+E
Sbjct: 424 --------LETERQLGEAHGRLKEQRQ----LSSEKLMD----KEQQVADLQLKLSRLEE 467
Query: 1141 QARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGE 1200
Q ++ + + EL+ QL + + KLRE+Q E ++ G+
Sbjct: 468 QLKEK-------VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGD 520
Query: 1201 LRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKE 1260
+ + + EAL + ++E S ++K + + A E + L L+E + ++
Sbjct: 521 KDQKI----QNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQ 576
Query: 1261 AGELRTGLQEVERSRLEARREL----QELRRQMKMLDSENTRLGRELAELQGRLALGERA 1316
+L L+ S +A+ L QE + ++ L + EL +L +
Sbjct: 577 VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEK 636
Query: 1317 EKESRRETLGLRQRLLKGEASLEVMRQELQ----VAQRKLQEQEGEFRTRERRLLGSLEE 1372
+ + + LL EA+ R +LQ AQ LQ+++ E ++ L++
Sbjct: 637 VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELN----KITTQLDQ 692
Query: 1373 ARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQ 1432
+ + +H LE L+ + + L + EG+ + LEA+ V+ + A
Sbjct: 693 VTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQD 752
Query: 1433 LGGLRSALRRGLGLGRAPS-----PAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQ 1487
L R L L L RA + + S D + + Q
Sbjct: 753 LQQQRQ-LNTDLEL-RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQ 810
Query: 1488 PPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERD 1547
T + E + ++ + EL+ + E++ L T+ S + +L+++ D
Sbjct: 811 ILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVS---D 867
Query: 1548 SATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVA---- 1603
S + + +K + + A ++ ++ +L +Q E+ + ++E + +L++
Sbjct: 868 SLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASH 927
Query: 1604 TLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEG 1663
L+ L + + +L +Q + + + E +L+G+ LK+ +SE + ++E +L+G
Sbjct: 928 QLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ---SSEQKKKQIE----ALQG 980
Query: 1664 ELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVE----- 1718
EL+ + L ++ E LQ ++ +++A + K LQ E+ +++
Sbjct: 981 ELKIAVLQKTELE---NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYG 1037
Query: 1719 -ESE-GALRDKVRGLTEALAQSSASLNSTR----DKNLHLQKALTA---CEHDRQVLQER 1769
ESE A R ++ + E L+ + L S R ++N +Q+ TA E D +++
Sbjct: 1038 RESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQ 1097
Query: 1770 LDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAA 1829
L +AL + +K+ S +++ + ++A++E + E ++ +L E L+ + +
Sbjct: 1098 LQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSH---KLES 1154
Query: 1830 LNTVQKLQDERRLL-QERL---GSLQRALAQLEAEKR-------EVERSALRLEKDRVAL 1878
+ + L+D ++LL Q++L G A +E EKR +V++ L+K+ +
Sbjct: 1155 IKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEK 1214
Query: 1879 RRTLDKVEREK---LRSHEDT-VRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQ---- 1930
L +EK ++ HE+ +L+ + L+ L + E +QR++ +LE Q
Sbjct: 1215 EAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDL 1274
Query: 1931 ---VVVLEQSHSPAQLEVDAQQQQ-LELQQEVERLRSAQAQTERTLEARERAHRQRVRGL 1986
+ VLE + Q E A ++ L+ + E+E+L++ + +R L+ A V+ L
Sbjct: 1275 RGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAA----VQEL 1330
Query: 1987 EEQVSTLKGQLQQELRRSSA 2006
+ +L+ + Q L R A
Sbjct: 1331 GRENQSLQIKHTQALNRKWA 1350
Score = 177 bits (450), Expect = 7e-44
Identities = 279/1395 (20%), Positives = 569/1395 (40%), Gaps = 191/1395 (13%)
Query: 611 SLQVAQQQAEELRQEREKLQAA-------QEELRRQRDRLEE-EQEDAVQDG--ARVRRE 660
+L + + LRQE + LQA+ EEL+++ ++ + +Q++A DG E
Sbjct: 77 NLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAE 136
Query: 661 LERSHRQLEQ--------------LEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEV 706
L+ +QLE+ E K + LA E+ +++ R+ + + +
Sbjct: 137 LQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRL 196
Query: 707 AEALTKAEAGRVELELSMTKLRAEE--ASLQDSLSKLSALNESLAQDKLDLNRLVAQLEE 764
E L K +L+ + + E A L+ L ++ L +++ L+ R +L++
Sbjct: 197 TEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMT---LERERESEKLKD 253
Query: 765 EKSALQGRQRQAEQEATVAREEQERLEELRLEQEVA-----RQGLEGSLRVAEQAQEALE 819
E LQ + A EAT++ Q R E + QEVA Q L+ S+ Q + L
Sbjct: 254 ECKKLQ--SQYASSEATIS---QLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLT 308
Query: 820 QQLPTLRHERSQLQEQ---------------------LAQLSRQLSGREQELEQARREAQ 858
+ L + ++L+E+ QL +LS E L + E
Sbjct: 309 ENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELS 368
Query: 859 RQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQR 918
+ EA ++ E + ++ L + +++ + +L+ E L L E +R
Sbjct: 369 EKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETER 428
Query: 919 QLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAER 978
QL + R ++ L+ KE QQ+ Q K S +E + +K+ +
Sbjct: 429 QLGEAHGRLKEQRQLSSEKLMDKE----------QQVADLQLKLSRLEEQLKEKVTNS-T 477
Query: 979 EAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEEL 1038
E Q L + + H+E Q LQ+ A RE + + Q+ Q+ ++++ + LEA ++
Sbjct: 478 ELQHQLDKTKQQHQEQ-QALQQSTTAKLREAQNDLEQVLRQI-GDKDQKIQNLEALLQKS 535
Query: 1039 SEEIAALQQERD---------EGLLLAESEKQQALSLKESEKTALSEKL--MGTRHSLAT 1087
E I+ L++ER+ EG ++ Q+ + + T L+EKL H A
Sbjct: 536 KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595
Query: 1088 ISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGK 1147
+L + Q++ A R QDR V +L + + +L +Q E+ ++V +L Q K
Sbjct: 596 ENLHDQVQEQKAHLRAAQDR--VLSLETSVNELNSQLNES----KEKVSQLDIQI----K 645
Query: 1148 QRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGE 1207
+ L AE +T R L+ L AQ L++ Q QE ++ L +
Sbjct: 646 AKTELLLSAEAAKTA------QRADLQNHLDTAQNALQDKQ-------QELNKITTQLDQ 692
Query: 1208 GAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTG 1267
+ + + +L S +K+ + + +SL+ E+ E ++ L EA L
Sbjct: 693 VTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL---------EADSL--- 740
Query: 1268 LQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETL-G 1326
EV+ S+ +A ++LQ+ R+ L+ T L ++L E++ + R + + + E L
Sbjct: 741 --EVKASKEQALQDLQQQRQLNTDLELRATELSKQL-EMEKEIVSSTRLDLQKKSEALES 797
Query: 1327 LRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARG 1386
++Q+L K E ++++Q+ + ++ + Q E R + + L++
Sbjct: 798 IKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK-------------- 843
Query: 1387 LELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGL 1446
++++ EA E + + +LS + ++E + + +AA L L+ L
Sbjct: 844 VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL-- 901
Query: 1447 GRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEA 1506
+ +TL+ + + L+ +
Sbjct: 902 --------------------------QVQMENTLKEQKELKKSLEKEKEASHQLKLELNS 935
Query: 1507 VRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEA 1566
++ L + L+ ++E +L+ + L + E ++ + +L+ AV + E
Sbjct: 936 MQEQLIQAQNTLKQNEKEEQQLQGNINELKQ---SSEQKKKQIEALQGELKIAVLQKTEL 992
Query: 1567 RRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKM 1626
+ +L+ ELA ++E + + + + L+ ESEL A+++ + +
Sbjct: 993 ENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 1627 KANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRV 1686
+ + + D + + +L+ + +LE D + Q LQ+R
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLE----------QDSAKKEQQLQERC 1102
Query: 1687 DSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTR 1746
+LQ D + + + + LA++EE + ++ L E L S L S +
Sbjct: 1103 KALQ----DIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEEL--KSHKLESIK 1156
Query: 1747 DKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRV 1806
+ +L+ A + LQ + D+ + A+ + ++ L +QV + E +L+ + +
Sbjct: 1157 EIT-NLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV---KKEEEELKKEFI 1212
Query: 1807 EAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVER 1866
E E +L +++++ G KL + L E LG++++ + E+E+
Sbjct: 1213 EKEA---KLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEK 1269
Query: 1867 SALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQ 1926
L + L T+ + E+ E ++ E +L + + +L +Q+
Sbjct: 1270 QTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQE 1329
Query: 1927 LEAQVVVLEQSHSPA 1941
L + L+ H+ A
Sbjct: 1330 LGRENQSLQIKHTQA 1344
Score = 149 bits (376), Expect = 3e-35
Identities = 250/1202 (20%), Positives = 490/1202 (40%), Gaps = 221/1202 (18%)
Query: 74 ASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQ- 132
+S+ L ++NQ L + L + E + + +E ++ + L Q L+ +L+++
Sbjct: 295 SSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQK-DLDCQQLQSRL 353
Query: 133 --EPRGLVRQSVEL----------RRQLQEEQASYRRKLQAYQEGQQRQAQLVQ---RLQ 177
L R VEL + +L E + Y+ +++ QQ++ + Q +LQ
Sbjct: 354 SASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQ 413
Query: 178 GKILQYKKRCSELEQQLLERSGELEQQR------LRDTEHS-QDLESALIRLEEEQQ--- 227
+I Q + E E+QL E G L++QR L D E DL+ L RLEE+ +
Sbjct: 414 SEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKV 473
Query: 228 -RSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFN 286
S L ++Q + + Q+ + +R+ ND + +++ ++ ++ ++
Sbjct: 474 TNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKD----QKIQNLE 529
Query: 287 AYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGL 346
A + LL ++ DL A +AG G + L
Sbjct: 530 ALLQKSKENISLLEKE---------------REDLY-----------AKIQAGEGETAVL 563
Query: 347 RLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAV 406
+ + E+ L +L+ Q +++L Q + RV L +V
Sbjct: 564 NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 623
Query: 407 KRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSES 466
L Q E + L +++A L L +AA +T LQ L D AQ L D +
Sbjct: 624 NELNSQLNESKEKVSQLDIQIKAKTELLLSAEAA-KTAQRADLQNHL-DTAQNALQDKQQ 681
Query: 467 GVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHS 526
L ++ Q D T L
Sbjct: 682 ----------------ELNKITTQ-------------------------LDQVTAKLQDK 700
Query: 527 ALHKRQLQ--VQDMRGRY----EASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGA 580
H QL+ +++ + +Y + +++L G ++K +DS + + E+ LQ
Sbjct: 701 QEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQ--------- 751
Query: 581 MQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQR 640
++Q+ R N L + L+ L++ ++ R + +K A E ++++
Sbjct: 752 ---------DLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802
Query: 641 DRLEEEQEDAVQDGARVRRELERSHR-----------QLEQLEGKRSVLAKELVEVREAL 689
+ EEE++ QD + +E + H +L++++ ++ L EL V++ L
Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
Query: 690 SRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAE-EASLQDSLSKLSALNESL 748
S+ + D L+ K+E + K +A ++LE + +L+ + + ++++L + L +SL
Sbjct: 863 SKVS---DSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL 919
Query: 749 AQD-------KLDLNRLVAQL----------EEEKSALQGRQRQAEQEATVAREEQERLE 791
++ KL+LN + QL E+E+ LQG + +Q + +++ E L+
Sbjct: 920 EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQ 979
Query: 792 -ELR---LEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGRE 847
EL+ L++ L+ L A Q A ++++ L++ + QE QL GRE
Sbjct: 980 GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE 1039
Query: 848 QELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKE 907
EL R++ ++ EK +LA+E L++ + ++ L+ K
Sbjct: 1040 SELLATRQDL--------KSVEEKLSLAQE------DLISNRNQIGNQNKLIQELKTAKA 1085
Query: 908 ALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLR--QQIIATQEK--AS 963
LE + ++QL + + ++ E L ++ L E + L ++I QEK
Sbjct: 1086 TLEQDSAKKEQQLQERCKALQDIQKEKS---LKEKELVNEKSKLAEIEEIKCRQEKEITK 1142
Query: 964 LDKELMAQKLVQAE-----REAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQS 1018
L++EL + KL + ++A+ L +Q+ +LQ +AA + + + L+
Sbjct: 1143 LNEELKSHKLESIKEITNLKDAKQLLIQQKL----ELQGKADSLKAAVEQEKRNQQILKD 1198
Query: 1019 QLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKL 1078
Q+++E+EEL K+E E+ A L E EK+ + E + L+ ++
Sbjct: 1199 QVKKEEEEL-------KKEFIEKEAKLHSE--------IKEKEVGMKKHEENEAKLTMQI 1243
Query: 1079 MGTRHSLATISLEMERQKRDAQSRQEQ------DRSTVNALTSELRDLRAQREEAAAAHA 1132
+L T+ E + +R ++Q + + + A +D R E
Sbjct: 1244 TALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGE 1303
Query: 1133 QEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGRE 1192
E+ +LQ + +L ++ D+ +EL R+ ++ Q R+ E E
Sbjct: 1304 GEIEKLQTKVLELQRKLDNTTAAVQEL---------GRENQSLQIKHTQALNRKWAEDNE 1354
Query: 1193 VQ 1194
VQ
Sbjct: 1355 VQ 1356
Score = 100 bits (250), Expect = 1e-20
Identities = 166/799 (20%), Positives = 329/799 (41%), Gaps = 73/799 (9%)
Query: 1244 EQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARREL---QELRRQMKMLDSENTRLG 1300
E LAL + T + +E +L+ L+E + E ++EL Q L++Q D T
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 1301 RELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFR 1360
EL L+ +L +E++ E ++Q E + E+ + K E+
Sbjct: 135 AELQSLEQQL-------EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLRE 187
Query: 1361 TRERRLLGSLEEARGTE------KQQLDHARGLE----LKLEAARAEAAELGLRLSAAEG 1410
E+++ EE K +L G+E LK E + + + L E
Sbjct: 188 AAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLE-RER 246
Query: 1411 RAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGS-----PARDA 1465
++ L+ E +++ Q ++EA + LRS L +G + + S
Sbjct: 247 ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT 306
Query: 1466 PAEGSGEGLNSPSTLECSPGSQPPSPGPATSPA-SPDLDPEAVRGALREFLQELRSAQRE 1524
E + + LE + S + DLD + ++ L L E
Sbjct: 307 LTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE 366
Query: 1525 RDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQ 1584
E T L +L+E+E + + +QLQ+ E E+ + ++ + ++L
Sbjct: 367 LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET 426
Query: 1585 E----ESVRRSERERRATLD-------QVATLERSLQATESELRASQEKISKMKANETKL 1633
E E+ R + +R+ + + QVA L+ L E +L+ EK++ + +L
Sbjct: 427 ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLK---EKVTNSTELQHQL 483
Query: 1634 EGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDR-----EAQAQALQDRVDS 1688
+ K++ +E +S T KL + LE L+ ++G D+ EA Q ++ +
Sbjct: 484 DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR--QIGDKDQKIQNLEALLQKSKENISL 541
Query: 1689 LQRQVAD--SEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTR 1746
L+++ D ++++AG E L +++E L+++V LTE L S S +
Sbjct: 542 LEKEREDLYAKIQAG------EGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSES-HKQA 594
Query: 1747 DKNLH----LQKALTACEHDRQV-LQERLDAARQALSEARKQSSSLGEQVQTLRGEVADL 1801
+NLH QKA DR + L+ ++ L+E++++ S L Q++ +
Sbjct: 595 QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA 654
Query: 1802 ELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEK 1861
E + LQ + + + + LN + D+ + +L Q +QLE+
Sbjct: 655 EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQ---VTAKLQDKQEHCSQLESHL 711
Query: 1862 REVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQ 1921
+E + L LE+ L + K+E + L + + + + T EL E
Sbjct: 712 KEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELS 771
Query: 1922 RQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLE-LQQEVERLRSAQAQTERTLEARERAHR 1980
+Q+ ++E ++V S +L++ + + LE ++Q++ + + ++ E + +
Sbjct: 772 KQL-EMEKEIV------SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETK 824
Query: 1981 QRVRGLEEQVSTLKGQLQQ 1999
+ L ++ T +LQ+
Sbjct: 825 IQHEELNNRIQTTVTELQK 843
Score = 97.1 bits (240), Expect = 2e-19
Identities = 163/812 (20%), Positives = 340/812 (41%), Gaps = 92/812 (11%)
Query: 72 EMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELET 131
+ A L + Q+ L+ ++ + L +S+ + +L I+ A +E L L +T
Sbjct: 605 QKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELL-----LSAEAAKT 659
Query: 132 QEPRGLVRQSVELRRQLQEEQASYRR---KLQAYQEGQQRQAQLVQRLQGKILQYKKRCS 188
+ L + LQ++Q + +L Q + + +L+ + +YK++
Sbjct: 660 AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYL 719
Query: 189 ELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGS 248
LEQ+ E G++++ E E AL L++++Q + L L +QL+
Sbjct: 720 SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKE 779
Query: 249 ANQALSEDIRKVTNDWTRCRKEL---EHREAAWRREEESFNAYFSNEHSRLLLLWRQVVG 305
+ D++K + +++L E + +++ E+ + +H L + V
Sbjct: 780 IVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT 839
Query: 306 FRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAAL-------- 357
+ V K +L + +L++ S +++ + + + +AA+
Sbjct: 840 ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS----KSEFEKENQKGKAAILDLEKTCK 895
Query: 358 EKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKD 417
E + LQ Q+E L+++ +K L +++ S K +L++ +L A L++ E+
Sbjct: 896 ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955
Query: 418 QVNKDLTEKLEALESLRLQEQA---------ALETEDGEGLQQTLRDLAQAVLSDSESGV 468
Q+ ++ E ++ E + Q +A +TE LQQ L AQ + ++ E
Sbjct: 956 QLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE--- 1012
Query: 469 QLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLAL---IH 525
++S + + S + + L S GR +S LA +
Sbjct: 1013 KISVLQNNYEKSQETFKQL-----------QSDFYGR-----------ESELLATRQDLK 1050
Query: 526 SALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHE 585
S K L +D+ ++++ +G K + + ++ + LE+ + + +A +
Sbjct: 1051 SVEEKLSLAQEDL----ISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQ 1106
Query: 586 DAQREVQRLRSANEL-LSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE 644
D Q+E +S E L EKS LA ++ +Q +E+ + E+L++ + E ++ L+
Sbjct: 1107 DIQKE----KSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLK 1162
Query: 645 EEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKA 704
+ ++ +Q ++ + + +EQ + + +L ++ + E L K
Sbjct: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL-------------KK 1209
Query: 705 EVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLD---LNRLVAQ 761
E E K + E E+ M K EA L +++ALNE+L K + R V++
Sbjct: 1210 EFIEKEAKLHSEIKEKEVGMKKHEENEAKL---TMQITALNENLGTVKKEWQSSQRRVSE 1266
Query: 762 LEEEKSALQGRQRQAEQEATVAREEQER--LEELRLEQEVARQGLEGSLRVAEQAQEALE 819
LE++ L+G A EATV + ER L E L+ E + L+ + ++ +
Sbjct: 1267 LEKQTDDLRG--EIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTT 1324
Query: 820 QQLPTLRHERSQLQEQLAQLSRQLSGREQELE 851
+ L E LQ + Q + + E++
Sbjct: 1325 AAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 205 bits (521), Expect = 4e-52
Identities = 272/1197 (22%), Positives = 507/1197 (42%), Gaps = 179/1197 (14%)
Query: 555 QLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQV 614
Q++ E E +A E++LQ+ +++ + A+ E++ L + L+ EK+ L LQ
Sbjct: 846 QVTRQEEEMQAKEDELQKTKER-------QQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 615 AQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGK 674
+ E + R +L A ++EL +E AR+ E +R +QL+ +
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEME----------ARLEEEEDRG----QQLQAE 944
Query: 675 RSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASL 734
R +A++++++ E L R LQ EK V E + KL E +
Sbjct: 945 RKKMAQQMLDLEEQLEEEEAARQKLQLEK--------------VTAEAKIKKLEDEILVM 990
Query: 735 QDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELR 794
D +KLS + L + DL +A EEE+ A + + + E+ ++ E+R
Sbjct: 991 DDQNNKLSKERKLLEERISDLTTNLA--EEEEKAKNLTKLKNKHESMISE------LEVR 1042
Query: 795 LEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR 854
L++E E S + E+ + LE + + LQ Q+A+L QL+ +E+EL+ A
Sbjct: 1043 LKKE------EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1096
Query: 855 REAQRQVEALERAAREKEALAKEHAGLAVQLVA-------AEREGRTLSEEATRLRLEKE 907
++ A ++ L + L L + AE++ R L EE L+ E
Sbjct: 1097 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE-- 1154
Query: 908 ALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKE 967
LE +L Q +L A+RE Q + + K+ L E Q+ ++K + E
Sbjct: 1155 -LEDTLDSTATQ-QELRAKRE------QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206
Query: 968 LMAQKLVQAEREAQASLREQRAAHEED----------LQRLQREKEAAWRELEAERAQLQ 1017
+ ++L Q +R A+A+L + + E++ L + ++E E ++LEA+ +LQ
Sbjct: 1207 ELTEQLEQFKR-AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 1018 S-----------------QLQREQEE---LLARLEAEKEELSEEIAALQQERDEGLLLAE 1057
S +LQ E E +L E + +L++++A+L + + L +
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 1058 SEKQQALSLK------ESEKTALSEKL---MGTRHSLATISLEMERQKRDAQSRQEQDRS 1108
E +Q L++ E E+ +L ++L M + +L + Q D++ + + S
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385
Query: 1109 TVNAL-------TSELRDLRAQREEAAAAH---AQEVRRLQEQARDLGKQRDSCLREAEE 1158
TV AL E+ +L Q EE AAA+ + RLQ++ DL D+ +
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN----QRQ 1441
Query: 1159 LRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQE----AGELRRSLGEGAKEREA 1214
L + L + D L E K + ++ E + +E A L R+L E + +E
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1501
Query: 1215 LRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERS 1274
L R+N+ L KAE E L ++ VGK EL + +E
Sbjct: 1502 LERTNKML-----KAEMED----------------LVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 1275 RLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRE-TLGLRQRLLK 1333
E + +L+EL +++ + RL + L+G+ +A E E L+++L +
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 1334 GEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSL---EEARGTEKQQLDHARGLELK 1390
E LE R++ +A ++ EG+ + E + ++ EEA ++ + + +
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 1391 LEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAP 1450
LE ARA E+ E +A+ LEA+L +++ AAE RA
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE-----------------RAR 1703
Query: 1451 SPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGA 1510
A D E E L S+L Q A + + E +G
Sbjct: 1704 KQA----------DLEKEELAEEL--ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751
Query: 1511 LREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRS- 1569
+ +R A ++ ++L + + + E+ R + ++L+ + E E A +S
Sbjct: 1752 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1811
Query: 1570 VDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKAN 1629
++ ++A++A EE V + RE++A + ++ L+ ++ ++ + K
Sbjct: 1812 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1871
Query: 1630 ETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRV 1686
K ++LK L+ +E + ++ RR L+ EL + + AL+ ++
Sbjct: 1872 AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 201 bits (511), Expect = 6e-51
Identities = 270/1189 (22%), Positives = 513/1189 (43%), Gaps = 195/1189 (16%)
Query: 79 LQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLV 138
L EE LLQ++L +L A E +E+ ++ A + LE+ L LE +E RG
Sbjct: 885 LTEEKNLLQEQLQAETELYA----EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG-- 938
Query: 139 RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLL--- 195
+QLQ E+ +++ +E + + Q+LQ + + + + +LE ++L
Sbjct: 939 -------QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 991
Query: 196 ERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSE 255
+++ +L ++R E DL + L EE++++ +L ++ + ++++
Sbjct: 992 DQNNKLSKERKLLEERISDLTT---NLAEEEEKAKNLTKLK-----------NKHESMIS 1037
Query: 256 DIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKM 315
++ + R+ELE + + F H ++ L Q+ + +++ +
Sbjct: 1038 ELEVRLKKEEKSRQELEKLKRKLEGDASDF-------HEQIADLQAQIAELKMQLAKKEE 1090
Query: 316 FTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKV 375
+ L +L E+A+ + A+++ L S + L+ + + + E+Q RD +
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKI-----RELEGHISDLQEDLDSERAARNKAEKQKRD-L 1144
Query: 376 LREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRL 435
E + + +++ LD + T+ L KR ++ + K ++++ ++ +R
Sbjct: 1145 GEELEALKTELEDTLD-----STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 436 QEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRG---LSGQRT 492
+ A+E E E L+Q R A L +++T + N L G + GQ
Sbjct: 1200 KHAQAVE-ELTEQLEQFKRAKA-----------NLDKNKQTLEKENADLAGELRVLGQAK 1247
Query: 493 PSPPRRSSPGRGRSPRRGPSPACSDSS-TLALIHSALHKRQLQVQDMRG----------- 540
+ + + + CSD A ++ +HK Q +V+ + G
Sbjct: 1248 QEVEHKKK--KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305
Query: 541 ----------RYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQRE 590
+ + +Q+LL +Q + ++ R LEE+ L+D+ D M+A ++ +R
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 591 VQRLRSANELLSREKSNLAHSLQVA-------QQQAEELRQEREKLQAAQEELRRQRDRL 643
+ L ++ + A +++ Q++ E L Q+ E+ AA ++L + ++RL
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425
Query: 644 EEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEK 703
++E +D V D L+ + + LE K+ + L E + S+ +RD +AE
Sbjct: 1426 QQELDDLVVD-------LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1478
Query: 704 AE-------VAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLN 756
E +A AL +A + ELE + L+AE E L K D+
Sbjct: 1479 REKETKALSLARALEEALEAKEELERTNKMLKAE--------------MEDLVSSKDDVG 1524
Query: 757 RLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE 816
+ V +LE+ K AL+ + + + + +E + E+ +L EV Q L+G QA++
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584
Query: 817 ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE------AQRQVEA------- 863
Q +E+ QL RQL E ELE R++ A++++E
Sbjct: 1585 -------------EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1631
Query: 864 -LERAAREKEALAKEHAGLAVQLVAAERE---GRTLSEE--ATRLRLEKEA--LEGSLFE 915
+ A + +E K+ L Q+ +RE R +E AT EK+A LE L +
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Query: 916 VQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQ 975
+Q LA E R+Q + E KE L ELA A Q+ +K + ++ Q
Sbjct: 1692 LQEDLAAAERARKQADLE-------KEELAEELASSLSGRNALQD----EKRRLEARIAQ 1740
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQ------SQLQREQEELLA 1029
E E + A + +++ ++ E EL ER+ Q QL+R+ +EL +
Sbjct: 1741 LEEELEEEQGNMEAMSDR-VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 1030 RLE----AEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSL 1085
+L A K + IAAL+ + +A+ E+Q + + EK A ++ L L
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAK------IAQLEEQ--VEQEAREKQAATKSLKQKDKKL 1851
Query: 1086 ATISLEMERQKRDAQSRQEQDRSTVNALTSEL-RDLRAQREEAAAAHAQEVRRLQEQARD 1144
I L++E +++ A+ +EQ NA +L R L EE+ +A R+LQ + +
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKG-NARVKQLKRQLEEAEEESQRINANR-RKLQRELDE 1909
Query: 1145 LGKQRDSCLREAEELRTQLR------LLEDARDGLRRELLEAQRKLRES 1187
+ ++ RE L+++LR + R G RR + A E+
Sbjct: 1910 ATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEET 1958
Score = 191 bits (486), Expect = 5e-48
Identities = 275/1238 (22%), Positives = 514/1238 (41%), Gaps = 179/1238 (14%)
Query: 138 VRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLER 197
V+ +++ RQ +E QA +LQ +E QQ+ ++ L+ K QL E
Sbjct: 841 VKPLLQVTRQEEEMQAK-EDELQKTKERQQKAENELKELEQK-----------HSQLTEE 888
Query: 198 SGELEQQRLRDTEHSQDLESALIRLE-EEQQRSASLAQVNAMLREQLDQAGSANQALSED 256
L++Q +TE + E +RL ++Q+ L ++ A L E+ D+ Q L +
Sbjct: 889 KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG----QQLQAE 944
Query: 257 IRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMF 316
+K+ ++LE EAA RQ + ++ +E K+
Sbjct: 945 RKKMAQQMLDLEEQLEEEEAA-----------------------RQKLQLEKVTAEAKIK 981
Query: 317 TERDLLQL----GGELARTSRAVQEAGLGLSTGLRLAESRAEAALE---KQALLQAQLEE 369
D + + +L++ + ++E L+T L E +A+ + K + ++LE
Sbjct: 982 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041
Query: 370 QLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEA 429
+L+ + ++L + + + + D +D ++ +L + L+ Q +K++ +L L
Sbjct: 1042 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE---ELQAALAR 1098
Query: 430 LESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSG 489
L+ Q+ AL+ +R+L + +SD + + SER A
Sbjct: 1099 LDDEIAQKNNALKK---------IREL-EGHISDLQEDLD---SERAA------------ 1133
Query: 490 QRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLL 549
R + ++ G + DS+ Q++R + E +
Sbjct: 1134 -RNKAEKQKRDLGEELEALKTELEDTLDSTATQ-------------QELRAKREQE---V 1176
Query: 550 GTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSA----NELLSREK 605
L+K L + E R+ E Q+Q +R K A++ + + +R ++ + L +E
Sbjct: 1177 TVLKKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233
Query: 606 SNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSH 665
++LA L+V Q +E+ +++KL+A +EL+ + E + + +++ E+E
Sbjct: 1234 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293
Query: 666 RQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMT 725
L + EGK LAK++ + L +++LQ E + TK +
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDT---QELLQEETRQKLNVSTK-----------LR 1339
Query: 726 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVARE 785
+L E SLQD L + ++L + LN QL + K LQ E +
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQNLERHISTLN---IQLSDSKKKLQDFASTVEALEEGKKR 1396
Query: 786 EQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSG 845
Q+ +E L + E + + + Q+ L+ + L ++R QL L + R+
Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-QLVSNLEKKQRKF-- 1453
Query: 846 REQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATR---- 901
+Q L + + + + + +RA EA A+E A+ L A E EE R
Sbjct: 1454 -DQLLAEEKNISSKYADERDRA----EAEAREKETKALSLARALEEALEAKEELERTNKM 1508
Query: 902 LRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGEL-----AGLRQQII 956
L+ E E L S +V + + +LE + LE + + + E L EL A LR ++
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568
Query: 957 ATQEKASLDKELMAQKLVQAEREAQASLREQRAAHE-----EDLQRLQREKEAAWRELEA 1011
K +++L A+ E+ Q QR HE ED ++ + AA ++LE
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQL----QRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 1012 ERAQLQSQL------QREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS 1065
+ L+ Q + E + L +L+A+ ++ E+ + RDE A+ +++A S
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684
Query: 1066 LKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRA--- 1122
L E++ L E L + LE E + S S NAL E R L A
Sbjct: 1685 L-EADLMQLQEDLAAAERARKQADLEKEELAEELAS----SLSGRNALQDEKRRLEARIA 1739
Query: 1123 QREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
Q EE + + ++ R +Q + E R+ + E AR L R+ E +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 1183 KLRESQEGREVQ--------RQEAGELRRSLGEGAKEREA----LRRSNEELRSAVKKAE 1230
KL E + + + + +L + + A+E++A L++ +++L+ + + E
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1859
Query: 1231 SERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK 1290
ER K+A + KEQ E+ V +L+ L+E E ++L+R++
Sbjct: 1860 DER---KMAEQYKEQA----EKGNARVK----QLKRQLEEAEEESQRINANRRKLQRELD 1908
Query: 1291 MLDSENTRLGRELAELQGRLALGERAEKESRRETLGLR 1328
N +GRE+ L+ +L G R + G R
Sbjct: 1909 EATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRR 1946
Score = 187 bits (474), Expect = 1e-46
Identities = 274/1169 (23%), Positives = 506/1169 (43%), Gaps = 145/1169 (12%)
Query: 797 QEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQ---ELEQA 853
QE Q E L+ ++ Q+ E +L L + SQL E+ L QL + E E+
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 854 RREAQRQVEALERAAREKEALAKEHAGLAVQLVAAER---------EGRTLSEEATR--L 902
R + + LE E EA +E QL A + E + EEA R L
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969
Query: 903 RLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKA 962
+LEK E + +++ ++ ++ + +L E + L LT LA +E+
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA--------EEEEK 1021
Query: 963 SLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEA-------AWRELEAERAQ 1015
+ + + K E + L+++ + +E L++L+R+ E +L+A+ A+
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 1016 LQSQLQREQEELLARLEAEKEELSEEIAALQQERD-EGLLLAESE----KQQALSLKESE 1070
L+ QL +++EEL A L +E++++ AL++ R+ EG + E ++ A + E +
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 1071 KTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVN-ALTSELRDLRAQREEAAA 1129
K L E+L + L +L+ +++ ++++EQ+ + + AL E R AQ +E
Sbjct: 1141 KRDLGEELEALKTELED-TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 1130 AHAQEVRRLQEQAR-------DLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
HAQ V L EQ +L K + + +E +L +LR+L A+ + + + +
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANED 1242
+++E Q + EL + + E E++ E K + SL +D
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 1243 KEQKLALLEEARTAVG-----KEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENT 1297
++ L EE R + ++ E R LQ+ +EA+ Q L R + L+ + +
Sbjct: 1320 TQELLQ--EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK---QNLERHISTLNIQLS 1374
Query: 1298 RLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEG 1357
++L + + E +K ++E L Q+ + A+ + + + Q++L +
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434
Query: 1358 EFRTRERRLLGSLEEARGTEKQQLDHARGLELKL----EAARAEAAELGLR-LSAAEGRA 1412
+ +R+L+ +LE+ + Q L + + K + A AEA E + LS A
Sbjct: 1435 DL-DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1493
Query: 1413 QGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGE 1472
+ LEA+ +E + +A++ L S+ + G + E S
Sbjct: 1494 EALEAK-EELERTNKMLKAEMEDLVSS---------------KDDVGKNVHEL--EKSKR 1535
Query: 1473 GLNSPSTLECSPGSQPPSPGPATSPASPDLDP--EAVRGALREFLQELRSAQRERDELRT 1530
L + + + AT A L+ +A++G +F ++L++ + +E R
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG---QFERDLQARDEQNEEKRR 1592
Query: 1531 QTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRR 1590
Q L RQL E E E + + Q+A+A + A++ ++G L +L LQ +S +
Sbjct: 1593 Q---LQRQLHEYETELED-----ERKQRALAAA--AKKKLEGDLK----DLELQADSAIK 1638
Query: 1591 SERERRATLDQVATLERSLQATESELRASQEKI-SKMKANETK---LEGDKRRLKEVLDA 1646
E L ++ + Q + RAS+++I + K NE K LE D +L+E L A
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 1647 SESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLT 1706
+E + +L++ L EL S G + ALQD L+ ++A E
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRN-------ALQDEKRRLEARIAQLE--------- 1742
Query: 1707 VERLNGALAKVEESEG---ALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDR 1763
++EE +G A+ D+VR T+ Q S L + R + A E
Sbjct: 1743 --------EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 1764 QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQ 1823
+ L+ +L A+ K + + L ++A LE Q + + Q + L+Q+
Sbjct: 1795 KELRSKLHEMEGAVKSKFKST------IAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848
Query: 1824 EGEAAALNTVQKLQDERRLLQERLGSLQRALA---QLEAEKREVERSALRLEKDRVALRR 1880
+ L V+ DER++ ++ ++ A QL+ + E E + R+ +R L+R
Sbjct: 1849 KKLKEILLQVE---DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQR 1905
Query: 1881 TLDKVEREKLRSHEDTVR-LSAEKGRLDR 1908
LD E S+E R ++A K +L R
Sbjct: 1906 ELD----EATESNEAMGREVNALKSKLRR 1930
Score = 186 bits (472), Expect = 2e-46
Identities = 261/1203 (21%), Positives = 499/1203 (41%), Gaps = 163/1203 (13%)
Query: 639 QRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDM 698
Q R EEE + + + + +++ +L++LE K S L +E L ++
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE----------KNLLQEQ 895
Query: 699 LQAEK---AEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDL 755
LQAE AE E + A + ELE + ++ A +D +L A + +AQ LDL
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 756 NRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ 815
QLEEE++A Q +L+LE+ A E ++ E
Sbjct: 956 EE---QLEEEEAARQ---------------------KLQLEKVTA----EAKIKKLEDEI 987
Query: 816 EALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALA 875
++ Q L ER L+E+++ L+ L+ E++ + L + + E++
Sbjct: 988 LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN-----------LTKLKNKHESMI 1036
Query: 876 KEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQ 935
E L V+L E+ + L + +L + + ++Q Q+A+L+ + + E E Q
Sbjct: 1037 SE---LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1093
Query: 936 ALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL 995
A L L E+A + +E +L Q+ + +ER A+ +Q+ E+L
Sbjct: 1094 AAL---ARLDDEIAQKNNALKKIRELEGHISDL--QEDLDSERAARNKAEKQKRDLGEEL 1148
Query: 996 QRLQREKE------AAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQER 1049
+ L+ E E A +EL A+R Q + L++ +E EA+ +E+ ++ A +E
Sbjct: 1149 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1208
Query: 1050 DEGLLLAESEKQQALSLKESEKTALSEK--LMGTRHSLATISLEMERQKR--DAQSRQEQ 1105
E L E K+ +L ++++T E L G L E+E +K+ +AQ ++ Q
Sbjct: 1209 TEQL---EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 1106 DRST------------VNALTSELRDLRAQREEA---AAAHAQEVRRLQEQARDLGKQRD 1150
+ + V+ L +E+ + EA A A++V L Q +D +
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 1151 SCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAK 1210
R+ + T+LR LE+ R+ L Q +L E E ++ + L L + K
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSL-------QDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 1211 EREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQE 1270
+ + + E L K+ + E +L E+K LE+ + + +E +L L
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD- 1437
Query: 1271 VERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESR--------R 1322
++ + L++ +R+ L +E + + A+ + R A E EKE++
Sbjct: 1438 ---NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR-AEAEAREKETKALSLARALE 1493
Query: 1323 ETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLD 1382
E L ++ L + L+ ++L ++ + + E +R L +EE K QL+
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM----KTQLE 1549
Query: 1383 HARGLELKLEAARAEAAELGLRLSAAEGR-AQGLEAELARVEVQRRAAEAQLGGLRSALR 1441
LE +L+A L + + A +G+ + L+A + E +RR + QL + L
Sbjct: 1550 E---LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606
Query: 1442 RGLGLGRAPSPAPRPVPG-----SPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATS 1496
+ A + + G D+ +G E + L+
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ------------- 1653
Query: 1497 PASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQL 1556
+++F +EL A+ RDE+ ++ +EA+ QL
Sbjct: 1654 --------------MKDFQRELEDARASRDEIFATAKENEKKAKSLEAD-------LMQL 1692
Query: 1557 QKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESEL 1616
Q+ +A +E AR+ D + ELA + E+R ++A LE L+ + +
Sbjct: 1693 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1752
Query: 1617 RASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDR- 1675
A +++ K +L + + +ES +LE Q + L +L + +
Sbjct: 1753 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1812
Query: 1676 EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEAL 1735
++ AL+ ++ L+ QV E +A Q + L K++E + D+ R + E
Sbjct: 1813 KSTIAALEAKIAQLEEQV---EQEAREKQAATKSLKQKDKKLKEILLQVEDE-RKMAEQY 1868
Query: 1736 AQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLR 1795
+ + N+ + L++ L E + Q + ++ L EA + + ++G +V L+
Sbjct: 1869 KEQAEKGNA---RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1925
Query: 1796 GEV 1798
++
Sbjct: 1926 SKL 1928
Score = 184 bits (468), Expect = 6e-46
Identities = 289/1216 (23%), Positives = 522/1216 (42%), Gaps = 240/1216 (19%)
Query: 346 LRLAESRAEAALEKQALLQAQLEE--QLRDKVLREKDLAQQQMQSDLDKADLSARVTELG 403
++ E + E+Q + +L+E Q ++ EK+L Q+Q+Q++ TEL
Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE----------TELY 903
Query: 404 LAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSD 463
+ + + K Q +++ ++EA RL+E E + G+ LQ + +AQ +L
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEA----RLEE----EEDRGQQLQAERKKMAQQMLDL 955
Query: 464 SESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLAL 523
E QL E
Sbjct: 956 EE---QLEEEE------------------------------------------------- 963
Query: 524 IHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQA 583
+A K QL+ + + +D + + Q + ER+ LEE R+ D T +
Sbjct: 964 --AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE---RISDLTTNLAEE 1018
Query: 584 HEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQE----ELRRQ 639
E A + + +L++ +E + E L+V ++ E+ RQE EKL+ E + Q
Sbjct: 1019 EEKA-KNLTKLKNKHESMISE-------LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070
Query: 640 RDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDML 699
L+ + + A+ EL+ + +L+ +++ K++ E+ +S LQ D L
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS--DLQED-L 1127
Query: 700 QAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLV 759
+E+A A KAE + +L + L+ E L+D+L + E A+ + ++ L
Sbjct: 1128 DSERA----ARNKAEKQKRDLGEELEALKTE---LEDTLDSTATQQELRAKREQEVTVLK 1180
Query: 760 AQLEEEKSALQGRQRQAEQEATVAREE-QERLEELR------------LEQEVARQGLEG 806
L+EE + + + ++ Q+ A EE E+LE+ + LE+E A L G
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA--DLAG 1238
Query: 807 SLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQ---ELEQARREAQRQVEA 863
LRV QA++ +E H++ +L+ Q+ +L + S E+ EL + Q +VE+
Sbjct: 1239 ELRVLGQAKQEVE-------HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1291
Query: 864 LERAAREKEA----LAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQ 919
+ E E LAK+ A L+ QL ++ + L +E TR +L V +
Sbjct: 1292 VTGMLNEAEGKAIKLAKDVASLSSQL----QDTQELLQEETRQKLN----------VSTK 1337
Query: 920 LAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEK-----ASLDKELMAQKLV 974
L QLE R L+ + + AK+ L ++ L Q+ +++K ++++ +K
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 975 QAEREAQASLREQRAAHEEDLQ----RLQREKEAAWRELEAERAQLQSQLQREQEELLAR 1030
Q E E E++AA + L+ RLQ+E + +L+ +R QL S L+++Q + +
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-QLVSNLEKKQRKF-DQ 1455
Query: 1031 LEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEK------------- 1077
L AE++ +S + A ERD A ++ +ALSL + + AL K
Sbjct: 1456 LLAEEKNISSKYA---DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE 1512
Query: 1078 ---LMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELR---DLRAQRE-EAAAA 1130
L+ ++ + E+E+ KR +++ E+ ++ + L EL+ D + + E A
Sbjct: 1513 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL 1572
Query: 1131 HAQEVRRLQ-------EQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRK 1183
Q R LQ E+ R L +Q E E+ R Q L A+ L +L + + +
Sbjct: 1573 KGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ 1632
Query: 1184 LRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDK 1243
+ +GRE ++ +L+ + + +E E R S +E+ + K+ E + SL+
Sbjct: 1633 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1692
Query: 1244 EQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGREL 1303
++ LA E AR E EL L S L R LQ+ +R+ L++ +L EL
Sbjct: 1693 QEDLAAAERARKQADLEKEELAEELA----SSLSGRNALQDEKRR---LEARIAQLEEEL 1745
Query: 1304 AELQGRL-ALGERAEKESRR------ETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQE 1356
E QG + A+ +R K +++ E R K E++ + + ++ + + KL E E
Sbjct: 1746 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1805
Query: 1357 GEFRTRERRLLGSLE----------EARGTEKQ------------------QLDHARGL- 1387
G +++ + + +LE E EKQ Q++ R +
Sbjct: 1806 GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1865
Query: 1388 ---ELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEA---------QLGG 1435
+ + E A +L +L AE +Q + A R ++QR EA ++
Sbjct: 1866 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN--RRKLQRELDEATESNEAMGREVNA 1923
Query: 1436 LRSALRRGLGLGRAPS 1451
L+S LRRG PS
Sbjct: 1924 LKSKLRRGNETSFVPS 1939
Score = 179 bits (453), Expect = 3e-44
Identities = 271/1193 (22%), Positives = 506/1193 (42%), Gaps = 161/1193 (13%)
Query: 265 TRCRKELEHREAAWR----REEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERD 320
TR +E++ +E + R++++ N E L + + +L +E +++ E +
Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 907
Query: 321 LLQLGGELARTSRAVQEAGLGLSTGLRLAESRAE---AALEKQALLQAQLEEQLRDKVLR 377
+++ LA + ++E + L E R + A +K A LEEQL
Sbjct: 908 EMRV--RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE----- 960
Query: 378 EKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL--RL 435
E++ A+Q++Q L+K A++ K+LE + L D N L+++ + LE L
Sbjct: 961 EEEAARQKLQ--LEKVTAEAKI-------KKLEDEILVMDDQNNKLSKERKLLEERISDL 1011
Query: 436 QEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSP 495
A E E + L + L++ ++++S+ E V+L E++ R L G +
Sbjct: 1012 TTNLAEEEEKAKNLTK-LKNKHESMISELE--VRLKKEEKSRQELEKLKRKLEGDASD-- 1066
Query: 496 PRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQ 555
H + Q Q+ +++ + ++ L +
Sbjct: 1067 ----------------------------FHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098
Query: 556 LSDSESERRALEEQLQRLRDKTDGAMQAH-EDAQREVQRLRSANELLSREKSNLAHSLQV 614
L D +++ L+++R+ ++ H D Q ++ R+A ++K +L L+
Sbjct: 1099 LDDEIAQKN---NALKKIRE-----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 615 AQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHR-QLEQLEG 673
+ + E+ A Q+ELR +R EQE V A E RSH Q++++
Sbjct: 1151 LKTELEDTLDST----ATQQELRAKR-----EQEVTVLKKAL--DEETRSHEAQVQEMRQ 1199
Query: 674 KRSVLAKELVEVREALSRATLQRDM----LQAEKAEVAEALTKAEAGRVELELSMTKLRA 729
K + +EL E E RA D L+ E A++A L + E+E KL
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL-- 1257
Query: 730 EEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEAT-----VAR 784
EA +Q+ SK S + A+ LN V +L+ E ++ G +AE +A VA
Sbjct: 1258 -EAQVQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 785 EEQERLEELRLEQEVARQGLEGS--LRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 842
+ + L QE RQ L S LR E+ + +L+ QL + L+ ++ L+ Q
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 843 LSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRL 902
LS +++L+ + E +R +E E L +++ A E+ L +E L
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 903 RLE---KEALEGSLFEVQRQLAQLEARREQLEAE-----GQALLLAKETLTGELAGLRQQ 954
++ + L +L + QR+ QL A + + ++ +A A+E T L+ R
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492
Query: 955 IIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERA 1014
A + K L++ K+++AE E S ++ + +L++ +R E E++ +
Sbjct: 1493 EEALEAKEELER---TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1549
Query: 1015 QLQSQLQREQE------------------ELLARLEAEKE-------ELSEEIAALQQER 1049
+L+ +LQ ++ +L AR E +E +L E L+ ER
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609
Query: 1050 DEGLLLAESEKQQALSLKESEKTALS-----EKLMGTRHSLATISLEMERQKRDAQSRQE 1104
+ L A ++K+ LK+ E A S E+ + L + +R+ DA++ ++
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669
Query: 1105 QDRSTVNALTSELRDLRA-----QREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEEL 1159
+ +T + + L A Q + AAA A++ L+++ +L ++ S L L
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE--ELAEELASSLSGRNAL 1727
Query: 1160 RTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLG-------EGAKER 1212
+ + R LE L EL E Q + + Q+A +L L + R
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1787
Query: 1213 EALRRSNEELRSAVKKAESE-RISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEV 1271
+ L R N+ELRS + + E + K E K+A LEE +E L++
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847
Query: 1272 ERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLG---LR 1328
++ E ++++ R+ + + + + +L+ +L E AE+ES+R L+
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL---EEAEEESQRINANRRKLQ 1904
Query: 1329 QRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGS--LEEARGTEKQ 1379
+ L + S E M +E+ + KL+ RR G +E A G+E++
Sbjct: 1905 RELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEE 1957
Score = 176 bits (446), Expect = 2e-43
Identities = 268/1168 (22%), Positives = 503/1168 (43%), Gaps = 175/1168 (14%)
Query: 883 VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARR----EQLEAEGQALL 938
+Q+ E E + +E + + ++ E L E++++ +QL + EQL+AE +
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 939 LAKETLTGELAGLRQQI--IATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQ 996
A+E + LA +Q++ I + +A L++E + +QAER+ A +Q EE L+
Sbjct: 905 EAEE-MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA---QQMLDLEEQLE 960
Query: 997 RLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLA 1056
E+EAA ++L+ E+ ++++++ ++E+L ++ + +LS+E LL
Sbjct: 961 ----EEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERK----------LLE 1005
Query: 1057 ESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSE 1116
E +L E E+ A + + +H LE+ R K++ +SRQE
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV-RLKKEEKSRQE------------ 1052
Query: 1117 LRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDA----RDG 1172
L L+ + E A+ +++ LQ Q +L Q ++ EEL+ L L+D +
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQ---LAKKEEELQAALARLDDEIAQKNNA 1109
Query: 1173 LR--RELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAE 1230
L+ REL L+E + R +A + +R LGE E EAL+ E+ + A
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE---ELEALKTELEDTLDST--AT 1164
Query: 1231 SERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK 1290
+ + K E K AL EE R+ + + Q VE E +L++ +R
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE----ELTEQLEQFKRAKA 1220
Query: 1291 MLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQR 1350
LD L +E A+L G L + +A++E + + LE QELQ
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHK-----------KKKLEAQVQELQSKCS 1269
Query: 1351 KLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEG 1410
+ E + +L +E G L+ A G +KL + A L +L +
Sbjct: 1270 DGERARAELNDKVHKLQNEVESVTG----MLNEAEGKAIKLAK---DVASLSSQLQDTQE 1322
Query: 1411 RAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGS 1470
Q + V + R E + L+ L + A+ +
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDE---------------------EMEAKQN 1361
Query: 1471 GEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRT 1530
E S ++ S + +T EA+ + F +E+ + ++ +E
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTV--------EALEEGKKRFQKEIENLTQQYEEKAA 1413
Query: 1531 QTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLS---GVQAELALQEES 1587
L + ++ E D ++ V+ E+ +R D L+ + ++ A + +
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 1588 VRRSERERRA-TLDQVATLERSLQATES-------------ELRASQEKISK-------- 1625
RE+ L LE +L+A E +L +S++ + K
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 1626 MKANETKLEGDKRRLKEV---LDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQAL 1682
+A ET++E K +L+E+ L A+E ++LE+ ++L+G+ +R D +A+ +
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER------DLQARDEQN 1587
Query: 1683 QDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASL 1742
+++ LQRQ+ + E +L ER ALA A + K+ G + L + S
Sbjct: 1588 EEKRRQLQRQLHEYET-----ELEDERKQRALA------AAAKKKLEGDLKDLELQADSA 1636
Query: 1743 NSTRDKNLHLQKALTACEHDRQVLQERLDAARQAL----SEARKQSSSLGEQVQTLRGEV 1798
R++ + + L A D Q E A+R + E K++ SL + L+ ++
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696
Query: 1799 ADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLE 1858
A E R +A+ + ++L E L A++L+ LQDE+R L+ R+ L+ +LE
Sbjct: 1697 AAAERARKQADLEKEELAEEL-------ASSLSGRNALQDEKRRLEARIAQLEE---ELE 1746
Query: 1859 AEKREVERSALRLEKDRVALRRTLDKVEREKLRSHE-DTVRLSAEKGRLDRTLTGAELEL 1917
E+ +E + R+ K + +++ E+ + + ++ R E+ + E+E
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806
Query: 1918 AEAQR---QIQQLEAQVVVLEQSHSPAQLEVDAQQQQL---ELQQEVERLRSAQAQTERT 1971
A + I LEA++ LE+ Q+E +A+++Q L+Q+ ++L+ Q E
Sbjct: 1807 AVKSKFKSTIAALEAKIAQLEE-----QVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861
Query: 1972 LEARERAHRQRVRGLEEQVSTLKGQLQQ 1999
+ E+ Q +G +V LK QL++
Sbjct: 1862 RKMAEQYKEQAEKG-NARVKQLKRQLEE 1888
Score = 134 bits (337), Expect = 9e-31
Identities = 207/937 (22%), Positives = 392/937 (41%), Gaps = 133/937 (14%)
Query: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKERE 1213
R+ EE++ + ED + +A+ +L+E ++ +E L+ L E E
Sbjct: 849 RQEEEMQAK----EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL---QAETE 901
Query: 1214 ALRRSNE-ELRSAVKKAESERI--SLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQE 1270
+ E +R A KK E E I ++ E++E + L+ R + ++ +L L+E
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 1271 VERSR-------LEARRELQELRRQMKMLDSENTRLGRELAELQGRLA-----LGERAEK 1318
E +R + A ++++L ++ ++D +N +L +E L+ R++ L E EK
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 1319 ESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEK 1378
+ L K + E M EL+V +K ++ E +R+L G +A +
Sbjct: 1022 A---------KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG---DASDFHE 1069
Query: 1379 QQLD-HARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLR 1437
Q D A+ ELK++ A+ E L AA R L+ E+A+ + +L G
Sbjct: 1070 QIADLQAQIAELKMQLAKKEE-----ELQAALAR---LDDEIAQKNNALKKIR-ELEGHI 1120
Query: 1438 SALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSP 1497
S L+ L RA R RD E TL+ + Q
Sbjct: 1121 SDLQEDLDSERAA----RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR------- 1169
Query: 1498 ASPDLDPEAVRGALREF-------LQELRSAQRER-DELRTQTSALNRQLAEMEAERDSA 1549
A + + ++ AL E +QE+R + +EL Q R A ++ + +
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 1550 TSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSL 1609
L + +A++ V+ + ++A++ + ER R D+V L+ +
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Query: 1610 QATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSR 1669
++ L ++ K K+ + L + +E+L + + + + R LE E +
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 1670 LGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVR 1729
L + Q L+ + +L Q++DS+ K TVE L EE + + ++
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL-------EEGKKRFQKEIE 1402
Query: 1730 GLTEALAQSSASLNSTRDKNLHLQKAL----TACEHDRQV---LQERLDAARQALSEARK 1782
LT+ + +A+ + LQ+ L ++ RQ+ L+++ Q L+E +
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 1783 QSSSLGEQVQTLRGEVADLEL----------QRVEAEGQLQQLREVLRQRQEGEAAALNT 1832
SS ++ E + E + +EA+ +L++ ++L+ E ++ +
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522
Query: 1833 VQK----LQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALR-------RT 1881
V K L+ +R L+ ++ ++ L +LE E + E + LRLE + AL+ +
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582
Query: 1882 LDKVEREKLRS-----HEDTVRL----------SAEKGRLDRTLTGAELEL-------AE 1919
D+ EK R HE L +A K +L+ L EL+ E
Sbjct: 1583 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1642
Query: 1920 AQRQIQQLEAQVVVLEQSHSPAQLEVDA--------QQQQLELQQEVERLRSAQAQTERT 1971
A +Q+++L+AQ+ ++ A+ D +++ L+ ++ +L+ A ER
Sbjct: 1643 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER- 1701
Query: 1972 LEARERAHRQRVRGLEEQVSTLKGQ--LQQELRRSSA 2006
AR++A ++ EE S+L G+ LQ E RR A
Sbjct: 1702 --ARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1736
Score = 47.4 bits (111), Expect = 1e-04
Identities = 50/225 (22%), Positives = 101/225 (44%), Gaps = 41/225 (18%)
Query: 78 SLQEENQLLQQELSRVEDLLAQSRAERDELAIKY-------NAVSE----------RLEQ 120
SL+ + LQ++L+ E Q+ E++ELA + NA+ + +LE+
Sbjct: 1684 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1743
Query: 121 ALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGK- 179
L E G +E R VR++ + QL E A+ R Q + +Q+ + + L+ K
Sbjct: 1744 ELEEEQGNMEAMSDR--VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL 1801
Query: 180 --------------ILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEE 225
I + + ++LE+Q+ + + E + + + L+ L+++E+E
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861
Query: 226 ----QQRSASLAQVNA---MLREQLDQAGSANQALSEDIRKVTND 263
+Q + NA L+ QL++A +Q ++ + RK+ +
Sbjct: 1862 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1906
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 205 bits (521), Expect = 4e-52
Identities = 272/1197 (22%), Positives = 507/1197 (42%), Gaps = 179/1197 (14%)
Query: 555 QLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQV 614
Q++ E E +A E++LQ+ +++ + A+ E++ L + L+ EK+ L LQ
Sbjct: 853 QVTRQEEEMQAKEDELQKTKER-------QQKAENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 615 AQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGK 674
+ E + R +L A ++EL +E AR+ E +R +QL+ +
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEME----------ARLEEEEDRG----QQLQAE 951
Query: 675 RSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASL 734
R +A++++++ E L R LQ EK V E + KL E +
Sbjct: 952 RKKMAQQMLDLEEQLEEEEAARQKLQLEK--------------VTAEAKIKKLEDEILVM 997
Query: 735 QDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELR 794
D +KLS + L + DL +A EEE+ A + + + E+ ++ E+R
Sbjct: 998 DDQNNKLSKERKLLEERISDLTTNLA--EEEEKAKNLTKLKNKHESMISE------LEVR 1049
Query: 795 LEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR 854
L++E E S + E+ + LE + + LQ Q+A+L QL+ +E+EL+ A
Sbjct: 1050 LKKE------EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1103
Query: 855 REAQRQVEALERAAREKEALAKEHAGLAVQLVA-------AEREGRTLSEEATRLRLEKE 907
++ A ++ L + L L + AE++ R L EE L+ E
Sbjct: 1104 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE-- 1161
Query: 908 ALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKE 967
LE +L Q +L A+RE Q + + K+ L E Q+ ++K + E
Sbjct: 1162 -LEDTLDSTATQ-QELRAKRE------QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213
Query: 968 LMAQKLVQAEREAQASLREQRAAHEED----------LQRLQREKEAAWRELEAERAQLQ 1017
+ ++L Q +R A+A+L + + E++ L + ++E E ++LEA+ +LQ
Sbjct: 1214 ELTEQLEQFKR-AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 1018 S-----------------QLQREQEE---LLARLEAEKEELSEEIAALQQERDEGLLLAE 1057
S +LQ E E +L E + +L++++A+L + + L +
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 1058 SEKQQALSLK------ESEKTALSEKL---MGTRHSLATISLEMERQKRDAQSRQEQDRS 1108
E +Q L++ E E+ +L ++L M + +L + Q D++ + + S
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392
Query: 1109 TVNAL-------TSELRDLRAQREEAAAAH---AQEVRRLQEQARDLGKQRDSCLREAEE 1158
TV AL E+ +L Q EE AAA+ + RLQ++ DL D+ +
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN----QRQ 1448
Query: 1159 LRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQE----AGELRRSLGEGAKEREA 1214
L + L + D L E K + ++ E + +E A L R+L E + +E
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1508
Query: 1215 LRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERS 1274
L R+N+ L KAE E L ++ VGK EL + +E
Sbjct: 1509 LERTNKML-----KAEMED----------------LVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 1275 RLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRE-TLGLRQRLLK 1333
E + +L+EL +++ + RL + L+G+ +A E E L+++L +
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 1334 GEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSL---EEARGTEKQQLDHARGLELK 1390
E LE R++ +A ++ EG+ + E + ++ EEA ++ + + +
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 1391 LEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAP 1450
LE ARA E+ E +A+ LEA+L +++ AAE RA
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE-----------------RAR 1710
Query: 1451 SPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGA 1510
A D E E L S+L Q A + + E +G
Sbjct: 1711 KQA----------DLEKEELAEEL--ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758
Query: 1511 LREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRS- 1569
+ +R A ++ ++L + + + E+ R + ++L+ + E E A +S
Sbjct: 1759 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1818
Query: 1570 VDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKAN 1629
++ ++A++A EE V + RE++A + ++ L+ ++ ++ + K
Sbjct: 1819 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1878
Query: 1630 ETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRV 1686
K ++LK L+ +E + ++ RR L+ EL + + AL+ ++
Sbjct: 1879 AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 201 bits (511), Expect = 6e-51
Identities = 270/1189 (22%), Positives = 513/1189 (43%), Gaps = 195/1189 (16%)
Query: 79 LQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLV 138
L EE LLQ++L +L A E +E+ ++ A + LE+ L LE +E RG
Sbjct: 892 LTEEKNLLQEQLQAETELYA----EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG-- 945
Query: 139 RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLL--- 195
+QLQ E+ +++ +E + + Q+LQ + + + + +LE ++L
Sbjct: 946 -------QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 998
Query: 196 ERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSE 255
+++ +L ++R E DL + L EE++++ +L ++ + ++++
Sbjct: 999 DQNNKLSKERKLLEERISDLTT---NLAEEEEKAKNLTKLK-----------NKHESMIS 1044
Query: 256 DIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKM 315
++ + R+ELE + + F H ++ L Q+ + +++ +
Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKLEGDASDF-------HEQIADLQAQIAELKMQLAKKEE 1097
Query: 316 FTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKV 375
+ L +L E+A+ + A+++ L S + L+ + + + E+Q RD +
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKI-----RELEGHISDLQEDLDSERAARNKAEKQKRD-L 1151
Query: 376 LREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRL 435
E + + +++ LD + T+ L KR ++ + K ++++ ++ +R
Sbjct: 1152 GEELEALKTELEDTLD-----STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 436 QEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRG---LSGQRT 492
+ A+E E E L+Q R A L +++T + N L G + GQ
Sbjct: 1207 KHAQAVE-ELTEQLEQFKRAKA-----------NLDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 493 PSPPRRSSPGRGRSPRRGPSPACSDSS-TLALIHSALHKRQLQVQDMRG----------- 540
+ + + + CSD A ++ +HK Q +V+ + G
Sbjct: 1255 QEVEHKKK--KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312
Query: 541 ----------RYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQRE 590
+ + +Q+LL +Q + ++ R LEE+ L+D+ D M+A ++ +R
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 591 VQRLRSANELLSREKSNLAHSLQVA-------QQQAEELRQEREKLQAAQEELRRQRDRL 643
+ L ++ + A +++ Q++ E L Q+ E+ AA ++L + ++RL
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432
Query: 644 EEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEK 703
++E +D V D L+ + + LE K+ + L E + S+ +RD +AE
Sbjct: 1433 QQELDDLVVD-------LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1485
Query: 704 AE-------VAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLN 756
E +A AL +A + ELE + L+AE E L K D+
Sbjct: 1486 REKETKALSLARALEEALEAKEELERTNKMLKAE--------------MEDLVSSKDDVG 1531
Query: 757 RLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE 816
+ V +LE+ K AL+ + + + + +E + E+ +L EV Q L+G QA++
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 817 ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE------AQRQVEA------- 863
Q +E+ QL RQL E ELE R++ A++++E
Sbjct: 1592 -------------EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1638
Query: 864 -LERAAREKEALAKEHAGLAVQLVAAERE---GRTLSEE--ATRLRLEKEA--LEGSLFE 915
+ A + +E K+ L Q+ +RE R +E AT EK+A LE L +
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Query: 916 VQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQ 975
+Q LA E R+Q + E KE L ELA A Q+ +K + ++ Q
Sbjct: 1699 LQEDLAAAERARKQADLE-------KEELAEELASSLSGRNALQD----EKRRLEARIAQ 1747
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQ------SQLQREQEELLA 1029
E E + A + +++ ++ E EL ER+ Q QL+R+ +EL +
Sbjct: 1748 LEEELEEEQGNMEAMSDR-VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 1030 RLE----AEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSL 1085
+L A K + IAAL+ + +A+ E+Q + + EK A ++ L L
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAK------IAQLEEQ--VEQEAREKQAATKSLKQKDKKL 1858
Query: 1086 ATISLEMERQKRDAQSRQEQDRSTVNALTSEL-RDLRAQREEAAAAHAQEVRRLQEQARD 1144
I L++E +++ A+ +EQ NA +L R L EE+ +A R+LQ + +
Sbjct: 1859 KEILLQVEDERKMAEQYKEQAEKG-NARVKQLKRQLEEAEEESQRINANR-RKLQRELDE 1916
Query: 1145 LGKQRDSCLREAEELRTQLR------LLEDARDGLRRELLEAQRKLRES 1187
+ ++ RE L+++LR + R G RR + A E+
Sbjct: 1917 ATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEET 1965
Score = 191 bits (486), Expect = 5e-48
Identities = 275/1238 (22%), Positives = 514/1238 (41%), Gaps = 179/1238 (14%)
Query: 138 VRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLER 197
V+ +++ RQ +E QA +LQ +E QQ+ ++ L+ K QL E
Sbjct: 848 VKPLLQVTRQEEEMQAK-EDELQKTKERQQKAENELKELEQK-----------HSQLTEE 895
Query: 198 SGELEQQRLRDTEHSQDLESALIRLE-EEQQRSASLAQVNAMLREQLDQAGSANQALSED 256
L++Q +TE + E +RL ++Q+ L ++ A L E+ D+ Q L +
Sbjct: 896 KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG----QQLQAE 951
Query: 257 IRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMF 316
+K+ ++LE EAA RQ + ++ +E K+
Sbjct: 952 RKKMAQQMLDLEEQLEEEEAA-----------------------RQKLQLEKVTAEAKIK 988
Query: 317 TERDLLQL----GGELARTSRAVQEAGLGLSTGLRLAESRAEAALE---KQALLQAQLEE 369
D + + +L++ + ++E L+T L E +A+ + K + ++LE
Sbjct: 989 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048
Query: 370 QLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEA 429
+L+ + ++L + + + + D +D ++ +L + L+ Q +K++ +L L
Sbjct: 1049 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE---ELQAALAR 1105
Query: 430 LESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSG 489
L+ Q+ AL+ +R+L + +SD + + SER A
Sbjct: 1106 LDDEIAQKNNALKK---------IREL-EGHISDLQEDLD---SERAA------------ 1140
Query: 490 QRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLL 549
R + ++ G + DS+ Q++R + E +
Sbjct: 1141 -RNKAEKQKRDLGEELEALKTELEDTLDSTATQ-------------QELRAKREQE---V 1183
Query: 550 GTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSA----NELLSREK 605
L+K L + E R+ E Q+Q +R K A++ + + +R ++ + L +E
Sbjct: 1184 TVLKKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240
Query: 606 SNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSH 665
++LA L+V Q +E+ +++KL+A +EL+ + E + + +++ E+E
Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300
Query: 666 RQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMT 725
L + EGK LAK++ + L +++LQ E + TK +
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDT---QELLQEETRQKLNVSTK-----------LR 1346
Query: 726 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVARE 785
+L E SLQD L + ++L + LN QL + K LQ E +
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLN---IQLSDSKKKLQDFASTVEALEEGKKR 1403
Query: 786 EQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSG 845
Q+ +E L + E + + + Q+ L+ + L ++R QL L + R+
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-QLVSNLEKKQRKF-- 1460
Query: 846 REQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATR---- 901
+Q L + + + + + +RA EA A+E A+ L A E EE R
Sbjct: 1461 -DQLLAEEKNISSKYADERDRA----EAEAREKETKALSLARALEEALEAKEELERTNKM 1515
Query: 902 LRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGEL-----AGLRQQII 956
L+ E E L S +V + + +LE + LE + + + E L EL A LR ++
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1575
Query: 957 ATQEKASLDKELMAQKLVQAEREAQASLREQRAAHE-----EDLQRLQREKEAAWRELEA 1011
K +++L A+ E+ Q QR HE ED ++ + AA ++LE
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQL----QRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 1012 ERAQLQSQL------QREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS 1065
+ L+ Q + E + L +L+A+ ++ E+ + RDE A+ +++A S
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691
Query: 1066 LKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRA--- 1122
L E++ L E L + LE E + S S NAL E R L A
Sbjct: 1692 L-EADLMQLQEDLAAAERARKQADLEKEELAEELAS----SLSGRNALQDEKRRLEARIA 1746
Query: 1123 QREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
Q EE + + ++ R +Q + E R+ + E AR L R+ E +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 1183 KLRESQEGREVQ--------RQEAGELRRSLGEGAKEREA----LRRSNEELRSAVKKAE 1230
KL E + + + + +L + + A+E++A L++ +++L+ + + E
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1866
Query: 1231 SERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK 1290
ER K+A + KEQ E+ V +L+ L+E E ++L+R++
Sbjct: 1867 DER---KMAEQYKEQA----EKGNARVK----QLKRQLEEAEEESQRINANRRKLQRELD 1915
Query: 1291 MLDSENTRLGRELAELQGRLALGERAEKESRRETLGLR 1328
N +GRE+ L+ +L G R + G R
Sbjct: 1916 EATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRR 1953
Score = 187 bits (474), Expect = 1e-46
Identities = 274/1169 (23%), Positives = 506/1169 (43%), Gaps = 145/1169 (12%)
Query: 797 QEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQ---ELEQA 853
QE Q E L+ ++ Q+ E +L L + SQL E+ L QL + E E+
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 854 RREAQRQVEALERAAREKEALAKEHAGLAVQLVAAER---------EGRTLSEEATR--L 902
R + + LE E EA +E QL A + E + EEA R L
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
Query: 903 RLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKA 962
+LEK E + +++ ++ ++ + +L E + L LT LA +E+
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA--------EEEEK 1028
Query: 963 SLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEA-------AWRELEAERAQ 1015
+ + + K E + L+++ + +E L++L+R+ E +L+A+ A+
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 1016 LQSQLQREQEELLARLEAEKEELSEEIAALQQERD-EGLLLAESE----KQQALSLKESE 1070
L+ QL +++EEL A L +E++++ AL++ R+ EG + E ++ A + E +
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 1071 KTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVN-ALTSELRDLRAQREEAAA 1129
K L E+L + L +L+ +++ ++++EQ+ + + AL E R AQ +E
Sbjct: 1148 KRDLGEELEALKTELED-TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 1130 AHAQEVRRLQEQAR-------DLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
HAQ V L EQ +L K + + +E +L +LR+L A+ + + + +
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANED 1242
+++E Q + EL + + E E++ E K + SL +D
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 1243 KEQKLALLEEARTAVG-----KEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENT 1297
++ L EE R + ++ E R LQ+ +EA+ Q L R + L+ + +
Sbjct: 1327 TQELLQ--EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK---QNLERHISTLNIQLS 1381
Query: 1298 RLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEG 1357
++L + + E +K ++E L Q+ + A+ + + + Q++L +
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441
Query: 1358 EFRTRERRLLGSLEEARGTEKQQLDHARGLELKL----EAARAEAAELGLR-LSAAEGRA 1412
+ +R+L+ +LE+ + Q L + + K + A AEA E + LS A
Sbjct: 1442 DL-DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1500
Query: 1413 QGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGE 1472
+ LEA+ +E + +A++ L S+ + G + E S
Sbjct: 1501 EALEAK-EELERTNKMLKAEMEDLVSS---------------KDDVGKNVHEL--EKSKR 1542
Query: 1473 GLNSPSTLECSPGSQPPSPGPATSPASPDLDP--EAVRGALREFLQELRSAQRERDELRT 1530
L + + + AT A L+ +A++G +F ++L++ + +E R
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG---QFERDLQARDEQNEEKRR 1599
Query: 1531 QTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRR 1590
Q L RQL E E E + + Q+A+A + A++ ++G L +L LQ +S +
Sbjct: 1600 Q---LQRQLHEYETELED-----ERKQRALAAA--AKKKLEGDLK----DLELQADSAIK 1645
Query: 1591 SERERRATLDQVATLERSLQATESELRASQEKI-SKMKANETK---LEGDKRRLKEVLDA 1646
E L ++ + Q + RAS+++I + K NE K LE D +L+E L A
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 1647 SESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLT 1706
+E + +L++ L EL S G + ALQD L+ ++A E
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRN-------ALQDEKRRLEARIAQLE--------- 1749
Query: 1707 VERLNGALAKVEESEG---ALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDR 1763
++EE +G A+ D+VR T+ Q S L + R + A E
Sbjct: 1750 --------EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1801
Query: 1764 QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQ 1823
+ L+ +L A+ K + + L ++A LE Q + + Q + L+Q+
Sbjct: 1802 KELRSKLHEMEGAVKSKFKST------IAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855
Query: 1824 EGEAAALNTVQKLQDERRLLQERLGSLQRALA---QLEAEKREVERSALRLEKDRVALRR 1880
+ L V+ DER++ ++ ++ A QL+ + E E + R+ +R L+R
Sbjct: 1856 KKLKEILLQVE---DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQR 1912
Query: 1881 TLDKVEREKLRSHEDTVR-LSAEKGRLDR 1908
LD E S+E R ++A K +L R
Sbjct: 1913 ELD----EATESNEAMGREVNALKSKLRR 1937
Score = 186 bits (472), Expect = 2e-46
Identities = 261/1203 (21%), Positives = 499/1203 (41%), Gaps = 163/1203 (13%)
Query: 639 QRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDM 698
Q R EEE + + + + +++ +L++LE K S L +E L ++
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE----------KNLLQEQ 902
Query: 699 LQAEK---AEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDL 755
LQAE AE E + A + ELE + ++ A +D +L A + +AQ LDL
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 756 NRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ 815
QLEEE++A Q +L+LE+ A E ++ E
Sbjct: 963 EE---QLEEEEAARQ---------------------KLQLEKVTA----EAKIKKLEDEI 994
Query: 816 EALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALA 875
++ Q L ER L+E+++ L+ L+ E++ + L + + E++
Sbjct: 995 LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN-----------LTKLKNKHESMI 1043
Query: 876 KEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQ 935
E L V+L E+ + L + +L + + ++Q Q+A+L+ + + E E Q
Sbjct: 1044 SE---LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1100
Query: 936 ALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL 995
A L L E+A + +E +L Q+ + +ER A+ +Q+ E+L
Sbjct: 1101 AAL---ARLDDEIAQKNNALKKIRELEGHISDL--QEDLDSERAARNKAEKQKRDLGEEL 1155
Query: 996 QRLQREKE------AAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQER 1049
+ L+ E E A +EL A+R Q + L++ +E EA+ +E+ ++ A +E
Sbjct: 1156 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1215
Query: 1050 DEGLLLAESEKQQALSLKESEKTALSEK--LMGTRHSLATISLEMERQKR--DAQSRQEQ 1105
E L E K+ +L ++++T E L G L E+E +K+ +AQ ++ Q
Sbjct: 1216 TEQL---EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 1106 DRST------------VNALTSELRDLRAQREEA---AAAHAQEVRRLQEQARDLGKQRD 1150
+ + V+ L +E+ + EA A A++V L Q +D +
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 1151 SCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAK 1210
R+ + T+LR LE+ R+ L Q +L E E ++ + L L + K
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSL-------QDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Query: 1211 EREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQE 1270
+ + + E L K+ + E +L E+K LE+ + + +E +L L
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD- 1444
Query: 1271 VERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESR--------R 1322
++ + L++ +R+ L +E + + A+ + R A E EKE++
Sbjct: 1445 ---NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR-AEAEAREKETKALSLARALE 1500
Query: 1323 ETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLD 1382
E L ++ L + L+ ++L ++ + + E +R L +EE K QL+
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM----KTQLE 1556
Query: 1383 HARGLELKLEAARAEAAELGLRLSAAEGR-AQGLEAELARVEVQRRAAEAQLGGLRSALR 1441
LE +L+A L + + A +G+ + L+A + E +RR + QL + L
Sbjct: 1557 E---LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613
Query: 1442 RGLGLGRAPSPAPRPVPG-----SPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATS 1496
+ A + + G D+ +G E + L+
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ------------- 1660
Query: 1497 PASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQL 1556
+++F +EL A+ RDE+ ++ +EA+ QL
Sbjct: 1661 --------------MKDFQRELEDARASRDEIFATAKENEKKAKSLEAD-------LMQL 1699
Query: 1557 QKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESEL 1616
Q+ +A +E AR+ D + ELA + E+R ++A LE L+ + +
Sbjct: 1700 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1759
Query: 1617 RASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDR- 1675
A +++ K +L + + +ES +LE Q + L +L + +
Sbjct: 1760 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1819
Query: 1676 EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEAL 1735
++ AL+ ++ L+ QV E +A Q + L K++E + D+ R + E
Sbjct: 1820 KSTIAALEAKIAQLEEQV---EQEAREKQAATKSLKQKDKKLKEILLQVEDE-RKMAEQY 1875
Query: 1736 AQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLR 1795
+ + N+ + L++ L E + Q + ++ L EA + + ++G +V L+
Sbjct: 1876 KEQAEKGNA---RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1932
Query: 1796 GEV 1798
++
Sbjct: 1933 SKL 1935
Score = 184 bits (468), Expect = 6e-46
Identities = 289/1216 (23%), Positives = 522/1216 (42%), Gaps = 240/1216 (19%)
Query: 346 LRLAESRAEAALEKQALLQAQLEE--QLRDKVLREKDLAQQQMQSDLDKADLSARVTELG 403
++ E + E+Q + +L+E Q ++ EK+L Q+Q+Q++ TEL
Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE----------TELY 910
Query: 404 LAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSD 463
+ + + K Q +++ ++EA RL+E E + G+ LQ + +AQ +L
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEA----RLEE----EEDRGQQLQAERKKMAQQMLDL 962
Query: 464 SESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLAL 523
E QL E
Sbjct: 963 EE---QLEEEE------------------------------------------------- 970
Query: 524 IHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQA 583
+A K QL+ + + +D + + Q + ER+ LEE R+ D T +
Sbjct: 971 --AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE---RISDLTTNLAEE 1025
Query: 584 HEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQE----ELRRQ 639
E A + + +L++ +E + E L+V ++ E+ RQE EKL+ E + Q
Sbjct: 1026 EEKA-KNLTKLKNKHESMISE-------LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077
Query: 640 RDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDML 699
L+ + + A+ EL+ + +L+ +++ K++ E+ +S LQ D L
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS--DLQED-L 1134
Query: 700 QAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLV 759
+E+A A KAE + +L + L+ E L+D+L + E A+ + ++ L
Sbjct: 1135 DSERA----ARNKAEKQKRDLGEELEALKTE---LEDTLDSTATQQELRAKREQEVTVLK 1187
Query: 760 AQLEEEKSALQGRQRQAEQEATVAREE-QERLEELR------------LEQEVARQGLEG 806
L+EE + + + ++ Q+ A EE E+LE+ + LE+E A L G
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA--DLAG 1245
Query: 807 SLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQ---ELEQARREAQRQVEA 863
LRV QA++ +E H++ +L+ Q+ +L + S E+ EL + Q +VE+
Sbjct: 1246 ELRVLGQAKQEVE-------HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1298
Query: 864 LERAAREKEA----LAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQ 919
+ E E LAK+ A L+ QL ++ + L +E TR +L V +
Sbjct: 1299 VTGMLNEAEGKAIKLAKDVASLSSQL----QDTQELLQEETRQKLN----------VSTK 1344
Query: 920 LAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEK-----ASLDKELMAQKLV 974
L QLE R L+ + + AK+ L ++ L Q+ +++K ++++ +K
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 975 QAEREAQASLREQRAAHEEDLQ----RLQREKEAAWRELEAERAQLQSQLQREQEELLAR 1030
Q E E E++AA + L+ RLQ+E + +L+ +R QL S L+++Q + +
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-QLVSNLEKKQRKF-DQ 1462
Query: 1031 LEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEK------------- 1077
L AE++ +S + A ERD A ++ +ALSL + + AL K
Sbjct: 1463 LLAEEKNISSKYA---DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE 1519
Query: 1078 ---LMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELR---DLRAQRE-EAAAA 1130
L+ ++ + E+E+ KR +++ E+ ++ + L EL+ D + + E A
Sbjct: 1520 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL 1579
Query: 1131 HAQEVRRLQ-------EQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRK 1183
Q R LQ E+ R L +Q E E+ R Q L A+ L +L + + +
Sbjct: 1580 KGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ 1639
Query: 1184 LRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDK 1243
+ +GRE ++ +L+ + + +E E R S +E+ + K+ E + SL+
Sbjct: 1640 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1699
Query: 1244 EQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGREL 1303
++ LA E AR E EL L S L R LQ+ +R+ L++ +L EL
Sbjct: 1700 QEDLAAAERARKQADLEKEELAEELA----SSLSGRNALQDEKRR---LEARIAQLEEEL 1752
Query: 1304 AELQGRL-ALGERAEKESRR------ETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQE 1356
E QG + A+ +R K +++ E R K E++ + + ++ + + KL E E
Sbjct: 1753 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1812
Query: 1357 GEFRTRERRLLGSLE----------EARGTEKQ------------------QLDHARGL- 1387
G +++ + + +LE E EKQ Q++ R +
Sbjct: 1813 GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1872
Query: 1388 ---ELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEA---------QLGG 1435
+ + E A +L +L AE +Q + A R ++QR EA ++
Sbjct: 1873 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN--RRKLQRELDEATESNEAMGREVNA 1930
Query: 1436 LRSALRRGLGLGRAPS 1451
L+S LRRG PS
Sbjct: 1931 LKSKLRRGNETSFVPS 1946
Score = 179 bits (453), Expect = 3e-44
Identities = 271/1193 (22%), Positives = 506/1193 (42%), Gaps = 161/1193 (13%)
Query: 265 TRCRKELEHREAAWR----REEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERD 320
TR +E++ +E + R++++ N E L + + +L +E +++ E +
Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 914
Query: 321 LLQLGGELARTSRAVQEAGLGLSTGLRLAESRAE---AALEKQALLQAQLEEQLRDKVLR 377
+++ LA + ++E + L E R + A +K A LEEQL
Sbjct: 915 EMRV--RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE----- 967
Query: 378 EKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL--RL 435
E++ A+Q++Q L+K A++ K+LE + L D N L+++ + LE L
Sbjct: 968 EEEAARQKLQ--LEKVTAEAKI-------KKLEDEILVMDDQNNKLSKERKLLEERISDL 1018
Query: 436 QEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSP 495
A E E + L + L++ ++++S+ E V+L E++ R L G +
Sbjct: 1019 TTNLAEEEEKAKNLTK-LKNKHESMISELE--VRLKKEEKSRQELEKLKRKLEGDASD-- 1073
Query: 496 PRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQ 555
H + Q Q+ +++ + ++ L +
Sbjct: 1074 ----------------------------FHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105
Query: 556 LSDSESERRALEEQLQRLRDKTDGAMQAH-EDAQREVQRLRSANELLSREKSNLAHSLQV 614
L D +++ L+++R+ ++ H D Q ++ R+A ++K +L L+
Sbjct: 1106 LDDEIAQKN---NALKKIRE-----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 615 AQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHR-QLEQLEG 673
+ + E+ A Q+ELR +R EQE V A E RSH Q++++
Sbjct: 1158 LKTELEDTLDST----ATQQELRAKR-----EQEVTVLKKAL--DEETRSHEAQVQEMRQ 1206
Query: 674 KRSVLAKELVEVREALSRATLQRDM----LQAEKAEVAEALTKAEAGRVELELSMTKLRA 729
K + +EL E E RA D L+ E A++A L + E+E KL
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL-- 1264
Query: 730 EEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEAT-----VAR 784
EA +Q+ SK S + A+ LN V +L+ E ++ G +AE +A VA
Sbjct: 1265 -EAQVQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 785 EEQERLEELRLEQEVARQGLEGS--LRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 842
+ + L QE RQ L S LR E+ + +L+ QL + L+ ++ L+ Q
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 843 LSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRL 902
LS +++L+ + E +R +E E L +++ A E+ L +E L
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 903 RLE---KEALEGSLFEVQRQLAQLEARREQLEAE-----GQALLLAKETLTGELAGLRQQ 954
++ + L +L + QR+ QL A + + ++ +A A+E T L+ R
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499
Query: 955 IIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERA 1014
A + K L++ K+++AE E S ++ + +L++ +R E E++ +
Sbjct: 1500 EEALEAKEELER---TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556
Query: 1015 QLQSQLQREQE------------------ELLARLEAEKE-------ELSEEIAALQQER 1049
+L+ +LQ ++ +L AR E +E +L E L+ ER
Sbjct: 1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616
Query: 1050 DEGLLLAESEKQQALSLKESEKTALS-----EKLMGTRHSLATISLEMERQKRDAQSRQE 1104
+ L A ++K+ LK+ E A S E+ + L + +R+ DA++ ++
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676
Query: 1105 QDRSTVNALTSELRDLRA-----QREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEEL 1159
+ +T + + L A Q + AAA A++ L+++ +L ++ S L L
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE--ELAEELASSLSGRNAL 1734
Query: 1160 RTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLG-------EGAKER 1212
+ + R LE L EL E Q + + Q+A +L L + R
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1794
Query: 1213 EALRRSNEELRSAVKKAESE-RISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEV 1271
+ L R N+ELRS + + E + K E K+A LEE +E L++
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854
Query: 1272 ERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLG---LR 1328
++ E ++++ R+ + + + + +L+ +L E AE+ES+R L+
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL---EEAEEESQRINANRRKLQ 1911
Query: 1329 QRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGS--LEEARGTEKQ 1379
+ L + S E M +E+ + KL+ RR G +E A G+E++
Sbjct: 1912 RELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEE 1964
Score = 176 bits (446), Expect = 2e-43
Identities = 268/1168 (22%), Positives = 503/1168 (43%), Gaps = 175/1168 (14%)
Query: 883 VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARR----EQLEAEGQALL 938
+Q+ E E + +E + + ++ E L E++++ +QL + EQL+AE +
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 939 LAKETLTGELAGLRQQI--IATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQ 996
A+E + LA +Q++ I + +A L++E + +QAER+ A +Q EE L+
Sbjct: 912 EAEE-MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA---QQMLDLEEQLE 967
Query: 997 RLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLA 1056
E+EAA ++L+ E+ ++++++ ++E+L ++ + +LS+E LL
Sbjct: 968 ----EEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERK----------LLE 1012
Query: 1057 ESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSE 1116
E +L E E+ A + + +H LE+ R K++ +SRQE
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV-RLKKEEKSRQE------------ 1059
Query: 1117 LRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDA----RDG 1172
L L+ + E A+ +++ LQ Q +L Q ++ EEL+ L L+D +
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQ---LAKKEEELQAALARLDDEIAQKNNA 1116
Query: 1173 LR--RELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAE 1230
L+ REL L+E + R +A + +R LGE E EAL+ E+ + A
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE---ELEALKTELEDTLDST--AT 1171
Query: 1231 SERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK 1290
+ + K E K AL EE R+ + + Q VE E +L++ +R
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE----ELTEQLEQFKRAKA 1227
Query: 1291 MLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQR 1350
LD L +E A+L G L + +A++E + + LE QELQ
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHK-----------KKKLEAQVQELQSKCS 1276
Query: 1351 KLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEG 1410
+ E + +L +E G L+ A G +KL + A L +L +
Sbjct: 1277 DGERARAELNDKVHKLQNEVESVTG----MLNEAEGKAIKLAK---DVASLSSQLQDTQE 1329
Query: 1411 RAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGS 1470
Q + V + R E + L+ L + A+ +
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDE---------------------EMEAKQN 1368
Query: 1471 GEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRT 1530
E S ++ S + +T EA+ + F +E+ + ++ +E
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTV--------EALEEGKKRFQKEIENLTQQYEEKAA 1420
Query: 1531 QTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLS---GVQAELALQEES 1587
L + ++ E D ++ V+ E+ +R D L+ + ++ A + +
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 1588 VRRSERERRA-TLDQVATLERSLQATES-------------ELRASQEKISK-------- 1625
RE+ L LE +L+A E +L +S++ + K
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 1626 MKANETKLEGDKRRLKEV---LDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQAL 1682
+A ET++E K +L+E+ L A+E ++LE+ ++L+G+ +R D +A+ +
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER------DLQARDEQN 1594
Query: 1683 QDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASL 1742
+++ LQRQ+ + E +L ER ALA A + K+ G + L + S
Sbjct: 1595 EEKRRQLQRQLHEYET-----ELEDERKQRALA------AAAKKKLEGDLKDLELQADSA 1643
Query: 1743 NSTRDKNLHLQKALTACEHDRQVLQERLDAARQAL----SEARKQSSSLGEQVQTLRGEV 1798
R++ + + L A D Q E A+R + E K++ SL + L+ ++
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 1799 ADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLE 1858
A E R +A+ + ++L E L A++L+ LQDE+R L+ R+ L+ +LE
Sbjct: 1704 AAAERARKQADLEKEELAEEL-------ASSLSGRNALQDEKRRLEARIAQLEE---ELE 1753
Query: 1859 AEKREVERSALRLEKDRVALRRTLDKVEREKLRSHE-DTVRLSAEKGRLDRTLTGAELEL 1917
E+ +E + R+ K + +++ E+ + + ++ R E+ + E+E
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813
Query: 1918 AEAQR---QIQQLEAQVVVLEQSHSPAQLEVDAQQQQL---ELQQEVERLRSAQAQTERT 1971
A + I LEA++ LE+ Q+E +A+++Q L+Q+ ++L+ Q E
Sbjct: 1814 AVKSKFKSTIAALEAKIAQLEE-----QVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868
Query: 1972 LEARERAHRQRVRGLEEQVSTLKGQLQQ 1999
+ E+ Q +G +V LK QL++
Sbjct: 1869 RKMAEQYKEQAEKG-NARVKQLKRQLEE 1895
Score = 134 bits (337), Expect = 9e-31
Identities = 207/937 (22%), Positives = 392/937 (41%), Gaps = 133/937 (14%)
Query: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKERE 1213
R+ EE++ + ED + +A+ +L+E ++ +E L+ L E E
Sbjct: 856 RQEEEMQAK----EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL---QAETE 908
Query: 1214 ALRRSNE-ELRSAVKKAESERI--SLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQE 1270
+ E +R A KK E E I ++ E++E + L+ R + ++ +L L+E
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 1271 VERSR-------LEARRELQELRRQMKMLDSENTRLGRELAELQGRLA-----LGERAEK 1318
E +R + A ++++L ++ ++D +N +L +E L+ R++ L E EK
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 1319 ESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEK 1378
+ L K + E M EL+V +K ++ E +R+L G +A +
Sbjct: 1029 A---------KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG---DASDFHE 1076
Query: 1379 QQLD-HARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLR 1437
Q D A+ ELK++ A+ E L AA R L+ E+A+ + +L G
Sbjct: 1077 QIADLQAQIAELKMQLAKKEE-----ELQAALAR---LDDEIAQKNNALKKIR-ELEGHI 1127
Query: 1438 SALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSP 1497
S L+ L RA R RD E TL+ + Q
Sbjct: 1128 SDLQEDLDSERAA----RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR------- 1176
Query: 1498 ASPDLDPEAVRGALREF-------LQELRSAQRER-DELRTQTSALNRQLAEMEAERDSA 1549
A + + ++ AL E +QE+R + +EL Q R A ++ + +
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236
Query: 1550 TSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSL 1609
L + +A++ V+ + ++A++ + ER R D+V L+ +
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Query: 1610 QATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSR 1669
++ L ++ K K+ + L + +E+L + + + + R LE E +
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356
Query: 1670 LGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVR 1729
L + Q L+ + +L Q++DS+ K TVE L EE + + ++
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL-------EEGKKRFQKEIE 1409
Query: 1730 GLTEALAQSSASLNSTRDKNLHLQKAL----TACEHDRQV---LQERLDAARQALSEARK 1782
LT+ + +A+ + LQ+ L ++ RQ+ L+++ Q L+E +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 1783 QSSSLGEQVQTLRGEVADLEL----------QRVEAEGQLQQLREVLRQRQEGEAAALNT 1832
SS ++ E + E + +EA+ +L++ ++L+ E ++ +
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529
Query: 1833 VQK----LQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALR-------RT 1881
V K L+ +R L+ ++ ++ L +LE E + E + LRLE + AL+ +
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589
Query: 1882 LDKVEREKLRS-----HEDTVRL----------SAEKGRLDRTLTGAELEL-------AE 1919
D+ EK R HE L +A K +L+ L EL+ E
Sbjct: 1590 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649
Query: 1920 AQRQIQQLEAQVVVLEQSHSPAQLEVDA--------QQQQLELQQEVERLRSAQAQTERT 1971
A +Q+++L+AQ+ ++ A+ D +++ L+ ++ +L+ A ER
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER- 1708
Query: 1972 LEARERAHRQRVRGLEEQVSTLKGQ--LQQELRRSSA 2006
AR++A ++ EE S+L G+ LQ E RR A
Sbjct: 1709 --ARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1743
Score = 47.4 bits (111), Expect = 1e-04
Identities = 50/225 (22%), Positives = 101/225 (44%), Gaps = 41/225 (18%)
Query: 78 SLQEENQLLQQELSRVEDLLAQSRAERDELAIKY-------NAVSE----------RLEQ 120
SL+ + LQ++L+ E Q+ E++ELA + NA+ + +LE+
Sbjct: 1691 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1750
Query: 121 ALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGK- 179
L E G +E R VR++ + QL E A+ R Q + +Q+ + + L+ K
Sbjct: 1751 ELEEEQGNMEAMSDR--VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL 1808
Query: 180 --------------ILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEE 225
I + + ++LE+Q+ + + E + + + L+ L+++E+E
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868
Query: 226 ----QQRSASLAQVNA---MLREQLDQAGSANQALSEDIRKVTND 263
+Q + NA L+ QL++A +Q ++ + RK+ +
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1913
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 205 bits (521), Expect = 4e-52
Identities = 272/1197 (22%), Positives = 507/1197 (42%), Gaps = 179/1197 (14%)
Query: 555 QLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQV 614
Q++ E E +A E++LQ+ +++ + A+ E++ L + L+ EK+ L LQ
Sbjct: 853 QVTRQEEEMQAKEDELQKTKER-------QQKAENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 615 AQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGK 674
+ E + R +L A ++EL +E AR+ E +R +QL+ +
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEME----------ARLEEEEDRG----QQLQAE 951
Query: 675 RSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASL 734
R +A++++++ E L R LQ EK V E + KL E +
Sbjct: 952 RKKMAQQMLDLEEQLEEEEAARQKLQLEK--------------VTAEAKIKKLEDEILVM 997
Query: 735 QDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELR 794
D +KLS + L + DL +A EEE+ A + + + E+ ++ E+R
Sbjct: 998 DDQNNKLSKERKLLEERISDLTTNLA--EEEEKAKNLTKLKNKHESMISE------LEVR 1049
Query: 795 LEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR 854
L++E E S + E+ + LE + + LQ Q+A+L QL+ +E+EL+ A
Sbjct: 1050 LKKE------EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1103
Query: 855 REAQRQVEALERAAREKEALAKEHAGLAVQLVA-------AEREGRTLSEEATRLRLEKE 907
++ A ++ L + L L + AE++ R L EE L+ E
Sbjct: 1104 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE-- 1161
Query: 908 ALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKE 967
LE +L Q +L A+RE Q + + K+ L E Q+ ++K + E
Sbjct: 1162 -LEDTLDSTATQ-QELRAKRE------QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213
Query: 968 LMAQKLVQAEREAQASLREQRAAHEED----------LQRLQREKEAAWRELEAERAQLQ 1017
+ ++L Q +R A+A+L + + E++ L + ++E E ++LEA+ +LQ
Sbjct: 1214 ELTEQLEQFKR-AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 1018 S-----------------QLQREQEE---LLARLEAEKEELSEEIAALQQERDEGLLLAE 1057
S +LQ E E +L E + +L++++A+L + + L +
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 1058 SEKQQALSLK------ESEKTALSEKL---MGTRHSLATISLEMERQKRDAQSRQEQDRS 1108
E +Q L++ E E+ +L ++L M + +L + Q D++ + + S
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392
Query: 1109 TVNAL-------TSELRDLRAQREEAAAAH---AQEVRRLQEQARDLGKQRDSCLREAEE 1158
TV AL E+ +L Q EE AAA+ + RLQ++ DL D+ +
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN----QRQ 1448
Query: 1159 LRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQE----AGELRRSLGEGAKEREA 1214
L + L + D L E K + ++ E + +E A L R+L E + +E
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1508
Query: 1215 LRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERS 1274
L R+N+ L KAE E L ++ VGK EL + +E
Sbjct: 1509 LERTNKML-----KAEMED----------------LVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 1275 RLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRE-TLGLRQRLLK 1333
E + +L+EL +++ + RL + L+G+ +A E E L+++L +
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 1334 GEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSL---EEARGTEKQQLDHARGLELK 1390
E LE R++ +A ++ EG+ + E + ++ EEA ++ + + +
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 1391 LEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAP 1450
LE ARA E+ E +A+ LEA+L +++ AAE RA
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE-----------------RAR 1710
Query: 1451 SPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGA 1510
A D E E L S+L Q A + + E +G
Sbjct: 1711 KQA----------DLEKEELAEEL--ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758
Query: 1511 LREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRS- 1569
+ +R A ++ ++L + + + E+ R + ++L+ + E E A +S
Sbjct: 1759 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1818
Query: 1570 VDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKAN 1629
++ ++A++A EE V + RE++A + ++ L+ ++ ++ + K
Sbjct: 1819 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1878
Query: 1630 ETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRV 1686
K ++LK L+ +E + ++ RR L+ EL + + AL+ ++
Sbjct: 1879 AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 201 bits (510), Expect = 8e-51
Identities = 264/1160 (22%), Positives = 504/1160 (43%), Gaps = 189/1160 (16%)
Query: 79 LQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLV 138
L EE LLQ++L +L A E +E+ ++ A + LE+ L LE +E RG
Sbjct: 892 LTEEKNLLQEQLQAETELYA----EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG-- 945
Query: 139 RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLL--- 195
+QLQ E+ +++ +E + + Q+LQ + + + + +LE ++L
Sbjct: 946 -------QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 998
Query: 196 ERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSE 255
+++ +L ++R E DL + L EE++++ +L ++ + ++++
Sbjct: 999 DQNNKLSKERKLLEERISDLTT---NLAEEEEKAKNLTKLK-----------NKHESMIS 1044
Query: 256 DIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKM 315
++ + R+ELE + + F H ++ L Q+ + +++ +
Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKLEGDASDF-------HEQIADLQAQIAELKMQLAKKEE 1097
Query: 316 FTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKV 375
+ L +L E+A+ + A+++ L S + L+ + + + E+Q RD +
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKI-----RELEGHISDLQEDLDSERAARNKAEKQKRD-L 1151
Query: 376 LREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRL 435
E + + +++ LD + T+ L KR ++ + K ++++ ++ +R
Sbjct: 1152 GEELEALKTELEDTLD-----STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 436 QEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRG---LSGQRT 492
+ A+E E E L+Q R A L +++T + N L G + GQ
Sbjct: 1207 KHAQAVE-ELTEQLEQFKRAKA-----------NLDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 493 PSPPRRSSPGRGRSPRRGPSPACSDSS-TLALIHSALHKRQLQVQDMRG----------- 540
+ + + + CSD A ++ +HK Q +V+ + G
Sbjct: 1255 QEVEHKKK--KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312
Query: 541 ----------RYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQRE 590
+ + +Q+LL +Q + ++ R LEE+ L+D+ D M+A ++ +R
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 591 VQRLRSANELLSREKSNLAHSLQVA-------QQQAEELRQEREKLQAAQEELRRQRDRL 643
+ L ++ + A +++ Q++ E L Q+ E+ AA ++L + ++RL
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432
Query: 644 EEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEK 703
++E +D V D L+ + + LE K+ + L E + S+ +RD +AE
Sbjct: 1433 QQELDDLVVD-------LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1485
Query: 704 AE-------VAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLN 756
E +A AL +A + ELE + L+AE E L K D+
Sbjct: 1486 REKETKALSLARALEEALEAKEELERTNKMLKAE--------------MEDLVSSKDDVG 1531
Query: 757 RLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE 816
+ V +LE+ K AL+ + + + + +E + E+ +L EV Q L+G QA++
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 817 ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE------AQRQVEA------- 863
Q +E+ QL RQL E ELE R++ A++++E
Sbjct: 1592 -------------EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1638
Query: 864 -LERAAREKEALAKEHAGLAVQLVAAERE---GRTLSEE--ATRLRLEKEA--LEGSLFE 915
+ A + +E K+ L Q+ +RE R +E AT EK+A LE L +
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Query: 916 VQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQ 975
+Q LA E R+Q + E KE L ELA A Q+ +K + ++ Q
Sbjct: 1699 LQEDLAAAERARKQADLE-------KEELAEELASSLSGRNALQD----EKRRLEARIAQ 1747
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQ------SQLQREQEELLA 1029
E E + A + +++ ++ E EL ER+ Q QL+R+ +EL +
Sbjct: 1748 LEEELEEEQGNMEAMSDR-VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 1030 RLE----AEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSL 1085
+L A K + IAAL+ + +A+ E+Q + + EK A ++ L L
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAK------IAQLEEQ--VEQEAREKQAATKSLKQKDKKL 1858
Query: 1086 ATISLEMERQKRDAQSRQEQDRSTVNALTSEL-RDLRAQREEAAAAHAQEVRRLQEQARD 1144
I L++E +++ A+ +EQ NA +L R L EE+ +A R+LQ + +
Sbjct: 1859 KEILLQVEDERKMAEQYKEQAEKG-NARVKQLKRQLEEAEEESQRINANR-RKLQRELDE 1916
Query: 1145 LGKQRDSCLREAEELRTQLR 1164
+ ++ RE L+++LR
Sbjct: 1917 ATESNEAMGREVNALKSKLR 1936
Score = 194 bits (493), Expect = 7e-49
Identities = 268/1188 (22%), Positives = 512/1188 (43%), Gaps = 143/1188 (12%)
Query: 265 TRCRKELEHREAAWR----REEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERD 320
TR +E++ +E + R++++ N E L + + +L +E +++ E +
Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 914
Query: 321 LLQLGGELARTSRAVQEAGLGLSTGLRLAESRAE---AALEKQALLQAQLEEQLRDKVLR 377
+++ LA + ++E + L E R + A +K A LEEQL
Sbjct: 915 EMRV--RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE----- 967
Query: 378 EKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL--RL 435
E++ A+Q++Q L+K A++ K+LE + L D N L+++ + LE L
Sbjct: 968 EEEAARQKLQ--LEKVTAEAKI-------KKLEDEILVMDDQNNKLSKERKLLEERISDL 1018
Query: 436 QEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSP 495
A E E + L + L++ ++++S+ E V+L E++ R L G +
Sbjct: 1019 TTNLAEEEEKAKNLTK-LKNKHESMISELE--VRLKKEEKSRQELEKLKRKLEGDASD-- 1073
Query: 496 PRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQ 555
H + Q Q+ +++ + ++ L +
Sbjct: 1074 ----------------------------FHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105
Query: 556 LSDSESERRALEEQLQRLRDKTDGAMQAH-EDAQREVQRLRSANELLSREKSNLAHSLQV 614
L D +++ L+++R+ ++ H D Q ++ R+A ++K +L L+
Sbjct: 1106 LDDEIAQKN---NALKKIRE-----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 615 AQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHR-QLEQLEG 673
+ + E+ A Q+ELR +R EQE V A E RSH Q++++
Sbjct: 1158 LKTELEDTLDST----ATQQELRAKR-----EQEVTVLKKAL--DEETRSHEAQVQEMRQ 1206
Query: 674 KRSVLAKELVEVREALSRATLQRDM----LQAEKAEVAEALTKAEAGRVELELSMTKLRA 729
K + +EL E E RA D L+ E A++A L + E+E KL
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL-- 1264
Query: 730 EEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEAT-----VAR 784
EA +Q+ SK S + A+ LN V +L+ E ++ G +AE +A VA
Sbjct: 1265 -EAQVQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 785 EEQERLEELRLEQEVARQGLEGS--LRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 842
+ + L QE RQ L S LR E+ + +L+ QL + L+ ++ L+ Q
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 843 LSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRL 902
LS +++L+ + E +R +E E L +++ A E+ L +E L
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 903 RLE---KEALEGSLFEVQRQLAQLEARREQLEAE-----GQALLLAKETLTGELAGLRQQ 954
++ + L +L + QR+ QL A + + ++ +A A+E T L+ R
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499
Query: 955 IIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERA 1014
A + K L++ K+++AE E S ++ + +L++ +R E E++ +
Sbjct: 1500 EEALEAKEELER---TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556
Query: 1015 QLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTAL 1074
+L+ +LQ ++ L RLE + L + Q RDE E ++ L
Sbjct: 1557 ELEDELQATEDAKL-RLEVNMQALKGQFERDLQARDEQ--------------NEEKRRQL 1601
Query: 1075 SEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQ- 1133
+L H T LE ER++R + ++ L +L+DL Q + A +
Sbjct: 1602 QRQL----HEYET-ELEDERKQRALAAAAKKK------LEGDLKDLELQADSAIKGREEA 1650
Query: 1134 --EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR 1191
++R+LQ Q +D ++ + +E+ + E L +L++ Q L ++ R
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710
Query: 1192 EVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLE 1251
+ E EL L R AL+ L + + + E E + E ++
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770
Query: 1252 EARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQM-KMLDSENTRLGRELAELQGRL 1310
+ + E R+ Q+ E +R + R+ +ELR ++ +M + ++ +A L+ ++
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1830
Query: 1311 A-LGERAEKESRRE---TLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRL 1366
A L E+ E+E+R + T L+Q+ K + L + E ++A++ +EQ + R ++L
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ-YKEQAEKGNARVKQL 1889
Query: 1367 LGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQG 1414
LEEA ++ + R L+ +L+ A +G ++A + + +G
Sbjct: 1890 KRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRG 1937
Score = 189 bits (479), Expect = 3e-47
Identities = 271/1220 (22%), Positives = 509/1220 (41%), Gaps = 179/1220 (14%)
Query: 138 VRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLER 197
V+ +++ RQ +E QA +LQ +E QQ+ ++ L+ K QL E
Sbjct: 848 VKPLLQVTRQEEEMQAK-EDELQKTKERQQKAENELKELEQK-----------HSQLTEE 895
Query: 198 SGELEQQRLRDTEHSQDLESALIRLE-EEQQRSASLAQVNAMLREQLDQAGSANQALSED 256
L++Q +TE + E +RL ++Q+ L ++ A L E+ D+ Q L +
Sbjct: 896 KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG----QQLQAE 951
Query: 257 IRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMF 316
+K+ ++LE EAA RQ + ++ +E K+
Sbjct: 952 RKKMAQQMLDLEEQLEEEEAA-----------------------RQKLQLEKVTAEAKIK 988
Query: 317 TERDLLQL----GGELARTSRAVQEAGLGLSTGLRLAESRAEAALE---KQALLQAQLEE 369
D + + +L++ + ++E L+T L E +A+ + K + ++LE
Sbjct: 989 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048
Query: 370 QLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEA 429
+L+ + ++L + + + + D +D ++ +L + L+ Q +K++ +L L
Sbjct: 1049 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE---ELQAALAR 1105
Query: 430 LESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSG 489
L+ Q+ AL+ +R+L + +SD + + SER A
Sbjct: 1106 LDDEIAQKNNALKK---------IREL-EGHISDLQEDLD---SERAA------------ 1140
Query: 490 QRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLL 549
R + ++ G + DS+ Q++R + E +
Sbjct: 1141 -RNKAEKQKRDLGEELEALKTELEDTLDSTATQ-------------QELRAKREQE---V 1183
Query: 550 GTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSA----NELLSREK 605
L+K L + E R+ E Q+Q +R K A++ + + +R ++ + L +E
Sbjct: 1184 TVLKKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240
Query: 606 SNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSH 665
++LA L+V Q +E+ +++KL+A +EL+ + E + + +++ E+E
Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300
Query: 666 RQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMT 725
L + EGK LAK++ + L +++LQ E + TK +
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDT---QELLQEETRQKLNVSTK-----------LR 1346
Query: 726 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVARE 785
+L E SLQD L + ++L + LN QL + K LQ E +
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLN---IQLSDSKKKLQDFASTVEALEEGKKR 1403
Query: 786 EQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSG 845
Q+ +E L + E + + + Q+ L+ + L ++R QL L + R+
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-QLVSNLEKKQRKF-- 1460
Query: 846 REQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATR---- 901
+Q L + + + + + +RA EA A+E A+ L A E EE R
Sbjct: 1461 -DQLLAEEKNISSKYADERDRA----EAEAREKETKALSLARALEEALEAKEELERTNKM 1515
Query: 902 LRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGEL-----AGLRQQII 956
L+ E E L S +V + + +LE + LE + + + E L EL A LR ++
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1575
Query: 957 ATQEKASLDKELMAQKLVQAEREAQASLREQRAAHE-----EDLQRLQREKEAAWRELEA 1011
K +++L A+ E+ Q QR HE ED ++ + AA ++LE
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQL----QRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 1012 ERAQLQSQL------QREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS 1065
+ L+ Q + E + L +L+A+ ++ E+ + RDE A+ +++A S
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691
Query: 1066 LKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRA--- 1122
L E++ L E L + LE E + S S NAL E R L A
Sbjct: 1692 L-EADLMQLQEDLAAAERARKQADLEKEELAEELAS----SLSGRNALQDEKRRLEARIA 1746
Query: 1123 QREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
Q EE + + ++ R +Q + E R+ + E AR L R+ E +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 1183 KLRESQEGREVQ--------RQEAGELRRSLGEGAKEREA----LRRSNEELRSAVKKAE 1230
KL E + + + + +L + + A+E++A L++ +++L+ + + E
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1866
Query: 1231 SERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK 1290
ER K+A + KEQ E+ V +L+ L+E E ++L+R++
Sbjct: 1867 DER---KMAEQYKEQA----EKGNARVK----QLKRQLEEAEEESQRINANRRKLQRELD 1915
Query: 1291 MLDSENTRLGRELAELQGRL 1310
N +GRE+ L+ +L
Sbjct: 1916 EATESNEAMGREVNALKSKL 1935
Score = 186 bits (472), Expect = 2e-46
Identities = 261/1203 (21%), Positives = 499/1203 (41%), Gaps = 163/1203 (13%)
Query: 639 QRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDM 698
Q R EEE + + + + +++ +L++LE K S L +E L ++
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE----------KNLLQEQ 902
Query: 699 LQAEK---AEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDL 755
LQAE AE E + A + ELE + ++ A +D +L A + +AQ LDL
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 756 NRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ 815
QLEEE++A Q +L+LE+ A E ++ E
Sbjct: 963 EE---QLEEEEAARQ---------------------KLQLEKVTA----EAKIKKLEDEI 994
Query: 816 EALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALA 875
++ Q L ER L+E+++ L+ L+ E++ + L + + E++
Sbjct: 995 LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN-----------LTKLKNKHESMI 1043
Query: 876 KEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQ 935
E L V+L E+ + L + +L + + ++Q Q+A+L+ + + E E Q
Sbjct: 1044 SE---LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1100
Query: 936 ALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL 995
A L L E+A + +E +L Q+ + +ER A+ +Q+ E+L
Sbjct: 1101 AAL---ARLDDEIAQKNNALKKIRELEGHISDL--QEDLDSERAARNKAEKQKRDLGEEL 1155
Query: 996 QRLQREKE------AAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQER 1049
+ L+ E E A +EL A+R Q + L++ +E EA+ +E+ ++ A +E
Sbjct: 1156 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1215
Query: 1050 DEGLLLAESEKQQALSLKESEKTALSEK--LMGTRHSLATISLEMERQKR--DAQSRQEQ 1105
E L E K+ +L ++++T E L G L E+E +K+ +AQ ++ Q
Sbjct: 1216 TEQL---EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 1106 DRST------------VNALTSELRDLRAQREEA---AAAHAQEVRRLQEQARDLGKQRD 1150
+ + V+ L +E+ + EA A A++V L Q +D +
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 1151 SCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAK 1210
R+ + T+LR LE+ R+ L Q +L E E ++ + L L + K
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSL-------QDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Query: 1211 EREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQE 1270
+ + + E L K+ + E +L E+K LE+ + + +E +L L
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD- 1444
Query: 1271 VERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESR--------R 1322
++ + L++ +R+ L +E + + A+ + R A E EKE++
Sbjct: 1445 ---NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR-AEAEAREKETKALSLARALE 1500
Query: 1323 ETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLD 1382
E L ++ L + L+ ++L ++ + + E +R L +EE K QL+
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM----KTQLE 1556
Query: 1383 HARGLELKLEAARAEAAELGLRLSAAEGR-AQGLEAELARVEVQRRAAEAQLGGLRSALR 1441
LE +L+A L + + A +G+ + L+A + E +RR + QL + L
Sbjct: 1557 E---LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613
Query: 1442 RGLGLGRAPSPAPRPVPG-----SPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATS 1496
+ A + + G D+ +G E + L+
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ------------- 1660
Query: 1497 PASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQL 1556
+++F +EL A+ RDE+ ++ +EA+ QL
Sbjct: 1661 --------------MKDFQRELEDARASRDEIFATAKENEKKAKSLEAD-------LMQL 1699
Query: 1557 QKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESEL 1616
Q+ +A +E AR+ D + ELA + E+R ++A LE L+ + +
Sbjct: 1700 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1759
Query: 1617 RASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDR- 1675
A +++ K +L + + +ES +LE Q + L +L + +
Sbjct: 1760 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1819
Query: 1676 EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEAL 1735
++ AL+ ++ L+ QV E +A Q + L K++E + D+ R + E
Sbjct: 1820 KSTIAALEAKIAQLEEQV---EQEAREKQAATKSLKQKDKKLKEILLQVEDE-RKMAEQY 1875
Query: 1736 AQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLR 1795
+ + N+ + L++ L E + Q + ++ L EA + + ++G +V L+
Sbjct: 1876 KEQAEKGNA---RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1932
Query: 1796 GEV 1798
++
Sbjct: 1933 SKL 1935
Score = 179 bits (454), Expect = 2e-44
Identities = 256/1138 (22%), Positives = 490/1138 (43%), Gaps = 122/1138 (10%)
Query: 797 QEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQ---ELEQA 853
QE Q E L+ ++ Q+ E +L L + SQL E+ L QL + E E+
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 854 RREAQRQVEALERAAREKEALAKEHAGLAVQLVAAER---------EGRTLSEEATR--L 902
R + + LE E EA +E QL A + E + EEA R L
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
Query: 903 RLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKA 962
+LEK E + +++ ++ ++ + +L E + L LT LA +E+
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA--------EEEEK 1028
Query: 963 SLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEA-------AWRELEAERAQ 1015
+ + + K E + L+++ + +E L++L+R+ E +L+A+ A+
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 1016 LQSQLQREQEELLARLEAEKEELSEEIAALQQERD-EGLLLAESE----KQQALSLKESE 1070
L+ QL +++EEL A L +E++++ AL++ R+ EG + E ++ A + E +
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 1071 KTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVN-ALTSELRDLRAQREEAAA 1129
K L E+L + L +L+ +++ ++++EQ+ + + AL E R AQ +E
Sbjct: 1148 KRDLGEELEALKTELED-TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 1130 AHAQEVRRLQEQAR-------DLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
HAQ V L EQ +L K + + +E +L +LR+L A+ + + + +
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANED 1242
+++E Q + EL + + E E++ E K + SL +D
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 1243 KEQKLALLEEARTAVG-----KEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENT 1297
++ L EE R + ++ E R LQ+ +EA+ Q L R + L+ + +
Sbjct: 1327 TQELLQ--EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK---QNLERHISTLNIQLS 1381
Query: 1298 RLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEG 1357
++L + + E +K ++E L Q+ + A+ + + + Q++L +
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441
Query: 1358 EFRTRERRLLGSLEEARGTEKQQLDHARGLELKL----EAARAEAAELGLR-LSAAEGRA 1412
+ +R+L+ +LE+ + Q L + + K + A AEA E + LS A
Sbjct: 1442 DL-DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1500
Query: 1413 QGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGE 1472
+ LEA+ +E + +A++ L S+ + G + E S
Sbjct: 1501 EALEAK-EELERTNKMLKAEMEDLVSS---------------KDDVGKNVHEL--EKSKR 1542
Query: 1473 GLNSPSTLECSPGSQPPSPGPATSPASPDLDP--EAVRGALREFLQELRSAQRERDELRT 1530
L + + + AT A L+ +A++G +F ++L++ + +E R
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG---QFERDLQARDEQNEEKRR 1599
Query: 1531 QTSALNRQLAEMEAE-------RDSATSRARQLQKAVAESE-EARRSVDGRLSGVQA--E 1580
Q L RQL E E E R A + ++L+ + + E +A ++ GR ++ +
Sbjct: 1600 Q---LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 1656
Query: 1581 LALQEESVRRSERERRATLDQVATL----ERSLQATESELRASQEKISKMKANETKLEGD 1636
L Q + +R + RA+ D++ E+ ++ E++L QE ++ + + + +
Sbjct: 1657 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716
Query: 1637 KRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADS 1696
K L E L +S S L+ ++R LE + + L + + +A+ DRV +Q
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL 1776
Query: 1697 EVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKAL 1756
+ T + T ++ A ++E LR K+ + A+ S + + +
Sbjct: 1777 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI------ 1830
Query: 1757 TACEHDRQVLQERLD--AARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQ 1814
+ + QV QE + AA ++L + K+ + QV+ R + Q + +++Q
Sbjct: 1831 --AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1888
Query: 1815 LREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVE--RSALR 1870
L+ L + +E Q++ RR LQ L A EA REV +S LR
Sbjct: 1889 LKRQLEEAEEES-------QRINANRRKLQR---ELDEATESNEAMGREVNALKSKLR 1936
Score = 176 bits (446), Expect = 2e-43
Identities = 268/1168 (22%), Positives = 503/1168 (43%), Gaps = 175/1168 (14%)
Query: 883 VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARR----EQLEAEGQALL 938
+Q+ E E + +E + + ++ E L E++++ +QL + EQL+AE +
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 939 LAKETLTGELAGLRQQI--IATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQ 996
A+E + LA +Q++ I + +A L++E + +QAER+ A +Q EE L+
Sbjct: 912 EAEE-MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA---QQMLDLEEQLE 967
Query: 997 RLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLA 1056
E+EAA ++L+ E+ ++++++ ++E+L ++ + +LS+E LL
Sbjct: 968 ----EEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERK----------LLE 1012
Query: 1057 ESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSE 1116
E +L E E+ A + + +H LE+ R K++ +SRQE
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV-RLKKEEKSRQE------------ 1059
Query: 1117 LRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDA----RDG 1172
L L+ + E A+ +++ LQ Q +L Q ++ EEL+ L L+D +
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQ---LAKKEEELQAALARLDDEIAQKNNA 1116
Query: 1173 LR--RELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAE 1230
L+ REL L+E + R +A + +R LGE E EAL+ E+ + A
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE---ELEALKTELEDTLDST--AT 1171
Query: 1231 SERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK 1290
+ + K E K AL EE R+ + + Q VE E +L++ +R
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE----ELTEQLEQFKRAKA 1227
Query: 1291 MLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQR 1350
LD L +E A+L G L + +A++E + + LE QELQ
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHK-----------KKKLEAQVQELQSKCS 1276
Query: 1351 KLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEG 1410
+ E + +L +E G L+ A G +KL + A L +L +
Sbjct: 1277 DGERARAELNDKVHKLQNEVESVTG----MLNEAEGKAIKLAK---DVASLSSQLQDTQE 1329
Query: 1411 RAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGS 1470
Q + V + R E + L+ L + A+ +
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDE---------------------EMEAKQN 1368
Query: 1471 GEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRT 1530
E S ++ S + +T EA+ + F +E+ + ++ +E
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTV--------EALEEGKKRFQKEIENLTQQYEEKAA 1420
Query: 1531 QTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLS---GVQAELALQEES 1587
L + ++ E D ++ V+ E+ +R D L+ + ++ A + +
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 1588 VRRSERERRA-TLDQVATLERSLQATES-------------ELRASQEKISK-------- 1625
RE+ L LE +L+A E +L +S++ + K
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 1626 MKANETKLEGDKRRLKEV---LDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQAL 1682
+A ET++E K +L+E+ L A+E ++LE+ ++L+G+ +R D +A+ +
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER------DLQARDEQN 1594
Query: 1683 QDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASL 1742
+++ LQRQ+ + E +L ER ALA A + K+ G + L + S
Sbjct: 1595 EEKRRQLQRQLHEYET-----ELEDERKQRALA------AAAKKKLEGDLKDLELQADSA 1643
Query: 1743 NSTRDKNLHLQKALTACEHDRQVLQERLDAARQAL----SEARKQSSSLGEQVQTLRGEV 1798
R++ + + L A D Q E A+R + E K++ SL + L+ ++
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 1799 ADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLE 1858
A E R +A+ + ++L E L A++L+ LQDE+R L+ R+ L+ +LE
Sbjct: 1704 AAAERARKQADLEKEELAEEL-------ASSLSGRNALQDEKRRLEARIAQLEE---ELE 1753
Query: 1859 AEKREVERSALRLEKDRVALRRTLDKVEREKLRSHE-DTVRLSAEKGRLDRTLTGAELEL 1917
E+ +E + R+ K + +++ E+ + + ++ R E+ + E+E
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813
Query: 1918 AEAQR---QIQQLEAQVVVLEQSHSPAQLEVDAQQQQL---ELQQEVERLRSAQAQTERT 1971
A + I LEA++ LE+ Q+E +A+++Q L+Q+ ++L+ Q E
Sbjct: 1814 AVKSKFKSTIAALEAKIAQLEE-----QVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868
Query: 1972 LEARERAHRQRVRGLEEQVSTLKGQLQQ 1999
+ E+ Q +G +V LK QL++
Sbjct: 1869 RKMAEQYKEQAEKG-NARVKQLKRQLEE 1895
Score = 134 bits (337), Expect = 9e-31
Identities = 207/937 (22%), Positives = 392/937 (41%), Gaps = 133/937 (14%)
Query: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKERE 1213
R+ EE++ + ED + +A+ +L+E ++ +E L+ L E E
Sbjct: 856 RQEEEMQAK----EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL---QAETE 908
Query: 1214 ALRRSNE-ELRSAVKKAESERI--SLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQE 1270
+ E +R A KK E E I ++ E++E + L+ R + ++ +L L+E
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 1271 VERSR-------LEARRELQELRRQMKMLDSENTRLGRELAELQGRLA-----LGERAEK 1318
E +R + A ++++L ++ ++D +N +L +E L+ R++ L E EK
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 1319 ESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEK 1378
+ L K + E M EL+V +K ++ E +R+L G +A +
Sbjct: 1029 A---------KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG---DASDFHE 1076
Query: 1379 QQLD-HARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLR 1437
Q D A+ ELK++ A+ E L AA R L+ E+A+ + +L G
Sbjct: 1077 QIADLQAQIAELKMQLAKKEE-----ELQAALAR---LDDEIAQKNNALKKIR-ELEGHI 1127
Query: 1438 SALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSP 1497
S L+ L RA R RD E TL+ + Q
Sbjct: 1128 SDLQEDLDSERAA----RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR------- 1176
Query: 1498 ASPDLDPEAVRGALREF-------LQELRSAQRER-DELRTQTSALNRQLAEMEAERDSA 1549
A + + ++ AL E +QE+R + +EL Q R A ++ + +
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236
Query: 1550 TSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSL 1609
L + +A++ V+ + ++A++ + ER R D+V L+ +
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Query: 1610 QATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSR 1669
++ L ++ K K+ + L + +E+L + + + + R LE E +
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356
Query: 1670 LGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVR 1729
L + Q L+ + +L Q++DS+ K TVE L EE + + ++
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL-------EEGKKRFQKEIE 1409
Query: 1730 GLTEALAQSSASLNSTRDKNLHLQKAL----TACEHDRQV---LQERLDAARQALSEARK 1782
LT+ + +A+ + LQ+ L ++ RQ+ L+++ Q L+E +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 1783 QSSSLGEQVQTLRGEVADLEL----------QRVEAEGQLQQLREVLRQRQEGEAAALNT 1832
SS ++ E + E + +EA+ +L++ ++L+ E ++ +
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1529
Query: 1833 VQK----LQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALR-------RT 1881
V K L+ +R L+ ++ ++ L +LE E + E + LRLE + AL+ +
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589
Query: 1882 LDKVEREKLRS-----HEDTVRL----------SAEKGRLDRTLTGAELEL-------AE 1919
D+ EK R HE L +A K +L+ L EL+ E
Sbjct: 1590 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649
Query: 1920 AQRQIQQLEAQVVVLEQSHSPAQLEVDA--------QQQQLELQQEVERLRSAQAQTERT 1971
A +Q+++L+AQ+ ++ A+ D +++ L+ ++ +L+ A ER
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER- 1708
Query: 1972 LEARERAHRQRVRGLEEQVSTLKGQ--LQQELRRSSA 2006
AR++A ++ EE S+L G+ LQ E RR A
Sbjct: 1709 --ARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1743
Score = 47.4 bits (111), Expect = 1e-04
Identities = 50/225 (22%), Positives = 101/225 (44%), Gaps = 41/225 (18%)
Query: 78 SLQEENQLLQQELSRVEDLLAQSRAERDELAIKY-------NAVSE----------RLEQ 120
SL+ + LQ++L+ E Q+ E++ELA + NA+ + +LE+
Sbjct: 1691 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1750
Query: 121 ALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGK- 179
L E G +E R VR++ + QL E A+ R Q + +Q+ + + L+ K
Sbjct: 1751 ELEEEQGNMEAMSDR--VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL 1808
Query: 180 --------------ILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEE 225
I + + ++LE+Q+ + + E + + + L+ L+++E+E
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868
Query: 226 ----QQRSASLAQVNA---MLREQLDQAGSANQALSEDIRKVTND 263
+Q + NA L+ QL++A +Q ++ + RK+ +
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1913
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 205 bits (521), Expect = 4e-52
Identities = 272/1197 (22%), Positives = 507/1197 (42%), Gaps = 179/1197 (14%)
Query: 555 QLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQV 614
Q++ E E +A E++LQ+ +++ + A+ E++ L + L+ EK+ L LQ
Sbjct: 846 QVTRQEEEMQAKEDELQKTKER-------QQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 615 AQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGK 674
+ E + R +L A ++EL +E AR+ E +R +QL+ +
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEME----------ARLEEEEDRG----QQLQAE 944
Query: 675 RSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASL 734
R +A++++++ E L R LQ EK V E + KL E +
Sbjct: 945 RKKMAQQMLDLEEQLEEEEAARQKLQLEK--------------VTAEAKIKKLEDEILVM 990
Query: 735 QDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELR 794
D +KLS + L + DL +A EEE+ A + + + E+ ++ E+R
Sbjct: 991 DDQNNKLSKERKLLEERISDLTTNLA--EEEEKAKNLTKLKNKHESMISE------LEVR 1042
Query: 795 LEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR 854
L++E E S + E+ + LE + + LQ Q+A+L QL+ +E+EL+ A
Sbjct: 1043 LKKE------EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1096
Query: 855 REAQRQVEALERAAREKEALAKEHAGLAVQLVA-------AEREGRTLSEEATRLRLEKE 907
++ A ++ L + L L + AE++ R L EE L+ E
Sbjct: 1097 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE-- 1154
Query: 908 ALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKE 967
LE +L Q +L A+RE Q + + K+ L E Q+ ++K + E
Sbjct: 1155 -LEDTLDSTATQ-QELRAKRE------QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206
Query: 968 LMAQKLVQAEREAQASLREQRAAHEED----------LQRLQREKEAAWRELEAERAQLQ 1017
+ ++L Q +R A+A+L + + E++ L + ++E E ++LEA+ +LQ
Sbjct: 1207 ELTEQLEQFKR-AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 1018 S-----------------QLQREQEE---LLARLEAEKEELSEEIAALQQERDEGLLLAE 1057
S +LQ E E +L E + +L++++A+L + + L +
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 1058 SEKQQALSLK------ESEKTALSEKL---MGTRHSLATISLEMERQKRDAQSRQEQDRS 1108
E +Q L++ E E+ +L ++L M + +L + Q D++ + + S
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385
Query: 1109 TVNAL-------TSELRDLRAQREEAAAAH---AQEVRRLQEQARDLGKQRDSCLREAEE 1158
TV AL E+ +L Q EE AAA+ + RLQ++ DL D+ +
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN----QRQ 1441
Query: 1159 LRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQE----AGELRRSLGEGAKEREA 1214
L + L + D L E K + ++ E + +E A L R+L E + +E
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1501
Query: 1215 LRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERS 1274
L R+N+ L KAE E L ++ VGK EL + +E
Sbjct: 1502 LERTNKML-----KAEMED----------------LVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 1275 RLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRE-TLGLRQRLLK 1333
E + +L+EL +++ + RL + L+G+ +A E E L+++L +
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 1334 GEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSL---EEARGTEKQQLDHARGLELK 1390
E LE R++ +A ++ EG+ + E + ++ EEA ++ + + +
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 1391 LEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAP 1450
LE ARA E+ E +A+ LEA+L +++ AAE RA
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE-----------------RAR 1703
Query: 1451 SPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGA 1510
A D E E L S+L Q A + + E +G
Sbjct: 1704 KQA----------DLEKEELAEEL--ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751
Query: 1511 LREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRS- 1569
+ +R A ++ ++L + + + E+ R + ++L+ + E E A +S
Sbjct: 1752 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1811
Query: 1570 VDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKAN 1629
++ ++A++A EE V + RE++A + ++ L+ ++ ++ + K
Sbjct: 1812 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1871
Query: 1630 ETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRV 1686
K ++LK L+ +E + ++ RR L+ EL + + AL+ ++
Sbjct: 1872 AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 201 bits (510), Expect = 8e-51
Identities = 264/1160 (22%), Positives = 504/1160 (43%), Gaps = 189/1160 (16%)
Query: 79 LQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLV 138
L EE LLQ++L +L A E +E+ ++ A + LE+ L LE +E RG
Sbjct: 885 LTEEKNLLQEQLQAETELYA----EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG-- 938
Query: 139 RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLL--- 195
+QLQ E+ +++ +E + + Q+LQ + + + + +LE ++L
Sbjct: 939 -------QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 991
Query: 196 ERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSE 255
+++ +L ++R E DL + L EE++++ +L ++ + ++++
Sbjct: 992 DQNNKLSKERKLLEERISDLTT---NLAEEEEKAKNLTKLK-----------NKHESMIS 1037
Query: 256 DIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKM 315
++ + R+ELE + + F H ++ L Q+ + +++ +
Sbjct: 1038 ELEVRLKKEEKSRQELEKLKRKLEGDASDF-------HEQIADLQAQIAELKMQLAKKEE 1090
Query: 316 FTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKV 375
+ L +L E+A+ + A+++ L S + L+ + + + E+Q RD +
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKI-----RELEGHISDLQEDLDSERAARNKAEKQKRD-L 1144
Query: 376 LREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRL 435
E + + +++ LD + T+ L KR ++ + K ++++ ++ +R
Sbjct: 1145 GEELEALKTELEDTLD-----STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 436 QEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRG---LSGQRT 492
+ A+E E E L+Q R A L +++T + N L G + GQ
Sbjct: 1200 KHAQAVE-ELTEQLEQFKRAKA-----------NLDKNKQTLEKENADLAGELRVLGQAK 1247
Query: 493 PSPPRRSSPGRGRSPRRGPSPACSDSS-TLALIHSALHKRQLQVQDMRG----------- 540
+ + + + CSD A ++ +HK Q +V+ + G
Sbjct: 1248 QEVEHKKK--KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305
Query: 541 ----------RYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQRE 590
+ + +Q+LL +Q + ++ R LEE+ L+D+ D M+A ++ +R
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 591 VQRLRSANELLSREKSNLAHSLQVA-------QQQAEELRQEREKLQAAQEELRRQRDRL 643
+ L ++ + A +++ Q++ E L Q+ E+ AA ++L + ++RL
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425
Query: 644 EEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEK 703
++E +D V D L+ + + LE K+ + L E + S+ +RD +AE
Sbjct: 1426 QQELDDLVVD-------LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1478
Query: 704 AE-------VAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLN 756
E +A AL +A + ELE + L+AE E L K D+
Sbjct: 1479 REKETKALSLARALEEALEAKEELERTNKMLKAE--------------MEDLVSSKDDVG 1524
Query: 757 RLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE 816
+ V +LE+ K AL+ + + + + +E + E+ +L EV Q L+G QA++
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584
Query: 817 ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE------AQRQVEA------- 863
Q +E+ QL RQL E ELE R++ A++++E
Sbjct: 1585 -------------EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1631
Query: 864 -LERAAREKEALAKEHAGLAVQLVAAERE---GRTLSEE--ATRLRLEKEA--LEGSLFE 915
+ A + +E K+ L Q+ +RE R +E AT EK+A LE L +
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Query: 916 VQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQ 975
+Q LA E R+Q + E KE L ELA A Q+ +K + ++ Q
Sbjct: 1692 LQEDLAAAERARKQADLE-------KEELAEELASSLSGRNALQD----EKRRLEARIAQ 1740
Query: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQ------SQLQREQEELLA 1029
E E + A + +++ ++ E EL ER+ Q QL+R+ +EL +
Sbjct: 1741 LEEELEEEQGNMEAMSDR-VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 1030 RLE----AEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSL 1085
+L A K + IAAL+ + +A+ E+Q + + EK A ++ L L
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAK------IAQLEEQ--VEQEAREKQAATKSLKQKDKKL 1851
Query: 1086 ATISLEMERQKRDAQSRQEQDRSTVNALTSEL-RDLRAQREEAAAAHAQEVRRLQEQARD 1144
I L++E +++ A+ +EQ NA +L R L EE+ +A R+LQ + +
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKG-NARVKQLKRQLEEAEEESQRINANR-RKLQRELDE 1909
Query: 1145 LGKQRDSCLREAEELRTQLR 1164
+ ++ RE L+++LR
Sbjct: 1910 ATESNEAMGREVNALKSKLR 1929
Score = 194 bits (493), Expect = 7e-49
Identities = 268/1188 (22%), Positives = 512/1188 (43%), Gaps = 143/1188 (12%)
Query: 265 TRCRKELEHREAAWR----REEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERD 320
TR +E++ +E + R++++ N E L + + +L +E +++ E +
Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 907
Query: 321 LLQLGGELARTSRAVQEAGLGLSTGLRLAESRAE---AALEKQALLQAQLEEQLRDKVLR 377
+++ LA + ++E + L E R + A +K A LEEQL
Sbjct: 908 EMRV--RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE----- 960
Query: 378 EKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL--RL 435
E++ A+Q++Q L+K A++ K+LE + L D N L+++ + LE L
Sbjct: 961 EEEAARQKLQ--LEKVTAEAKI-------KKLEDEILVMDDQNNKLSKERKLLEERISDL 1011
Query: 436 QEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSP 495
A E E + L + L++ ++++S+ E V+L E++ R L G +
Sbjct: 1012 TTNLAEEEEKAKNLTK-LKNKHESMISELE--VRLKKEEKSRQELEKLKRKLEGDASD-- 1066
Query: 496 PRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQ 555
H + Q Q+ +++ + ++ L +
Sbjct: 1067 ----------------------------FHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098
Query: 556 LSDSESERRALEEQLQRLRDKTDGAMQAH-EDAQREVQRLRSANELLSREKSNLAHSLQV 614
L D +++ L+++R+ ++ H D Q ++ R+A ++K +L L+
Sbjct: 1099 LDDEIAQKN---NALKKIRE-----LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 615 AQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHR-QLEQLEG 673
+ + E+ A Q+ELR +R EQE V A E RSH Q++++
Sbjct: 1151 LKTELEDTLDST----ATQQELRAKR-----EQEVTVLKKAL--DEETRSHEAQVQEMRQ 1199
Query: 674 KRSVLAKELVEVREALSRATLQRDM----LQAEKAEVAEALTKAEAGRVELELSMTKLRA 729
K + +EL E E RA D L+ E A++A L + E+E KL
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL-- 1257
Query: 730 EEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEAT-----VAR 784
EA +Q+ SK S + A+ LN V +L+ E ++ G +AE +A VA
Sbjct: 1258 -EAQVQELQSKCSDGERARAE----LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 785 EEQERLEELRLEQEVARQGLEGS--LRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQ 842
+ + L QE RQ L S LR E+ + +L+ QL + L+ ++ L+ Q
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 843 LSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRL 902
LS +++L+ + E +R +E E L +++ A E+ L +E L
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 903 RLE---KEALEGSLFEVQRQLAQLEARREQLEAE-----GQALLLAKETLTGELAGLRQQ 954
++ + L +L + QR+ QL A + + ++ +A A+E T L+ R
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492
Query: 955 IIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERA 1014
A + K L++ K+++AE E S ++ + +L++ +R E E++ +
Sbjct: 1493 EEALEAKEELER---TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1549
Query: 1015 QLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTAL 1074
+L+ +LQ ++ L RLE + L + Q RDE E ++ L
Sbjct: 1550 ELEDELQATEDAKL-RLEVNMQALKGQFERDLQARDEQ--------------NEEKRRQL 1594
Query: 1075 SEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQ- 1133
+L H T LE ER++R + ++ L +L+DL Q + A +
Sbjct: 1595 QRQL----HEYET-ELEDERKQRALAAAAKKK------LEGDLKDLELQADSAIKGREEA 1643
Query: 1134 --EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR 1191
++R+LQ Q +D ++ + +E+ + E L +L++ Q L ++ R
Sbjct: 1644 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703
Query: 1192 EVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLE 1251
+ E EL L R AL+ L + + + E E + E ++
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763
Query: 1252 EARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQM-KMLDSENTRLGRELAELQGRL 1310
+ + E R+ Q+ E +R + R+ +ELR ++ +M + ++ +A L+ ++
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1823
Query: 1311 A-LGERAEKESRRE---TLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRL 1366
A L E+ E+E+R + T L+Q+ K + L + E ++A++ +EQ + R ++L
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ-YKEQAEKGNARVKQL 1882
Query: 1367 LGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQG 1414
LEEA ++ + R L+ +L+ A +G ++A + + +G
Sbjct: 1883 KRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRG 1930
Score = 189 bits (479), Expect = 3e-47
Identities = 271/1220 (22%), Positives = 509/1220 (41%), Gaps = 179/1220 (14%)
Query: 138 VRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLER 197
V+ +++ RQ +E QA +LQ +E QQ+ ++ L+ K QL E
Sbjct: 841 VKPLLQVTRQEEEMQAK-EDELQKTKERQQKAENELKELEQK-----------HSQLTEE 888
Query: 198 SGELEQQRLRDTEHSQDLESALIRLE-EEQQRSASLAQVNAMLREQLDQAGSANQALSED 256
L++Q +TE + E +RL ++Q+ L ++ A L E+ D+ Q L +
Sbjct: 889 KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG----QQLQAE 944
Query: 257 IRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMF 316
+K+ ++LE EAA RQ + ++ +E K+
Sbjct: 945 RKKMAQQMLDLEEQLEEEEAA-----------------------RQKLQLEKVTAEAKIK 981
Query: 317 TERDLLQL----GGELARTSRAVQEAGLGLSTGLRLAESRAEAALE---KQALLQAQLEE 369
D + + +L++ + ++E L+T L E +A+ + K + ++LE
Sbjct: 982 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041
Query: 370 QLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEA 429
+L+ + ++L + + + + D +D ++ +L + L+ Q +K++ +L L
Sbjct: 1042 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE---ELQAALAR 1098
Query: 430 LESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSG 489
L+ Q+ AL+ +R+L + +SD + + SER A
Sbjct: 1099 LDDEIAQKNNALKK---------IREL-EGHISDLQEDLD---SERAA------------ 1133
Query: 490 QRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLL 549
R + ++ G + DS+ Q++R + E +
Sbjct: 1134 -RNKAEKQKRDLGEELEALKTELEDTLDSTATQ-------------QELRAKREQE---V 1176
Query: 550 GTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSA----NELLSREK 605
L+K L + E R+ E Q+Q +R K A++ + + +R ++ + L +E
Sbjct: 1177 TVLKKALDE---ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233
Query: 606 SNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSH 665
++LA L+V Q +E+ +++KL+A +EL+ + E + + +++ E+E
Sbjct: 1234 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293
Query: 666 RQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMT 725
L + EGK LAK++ + L +++LQ E + TK +
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDT---QELLQEETRQKLNVSTK-----------LR 1339
Query: 726 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVARE 785
+L E SLQD L + ++L + LN QL + K LQ E +
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQNLERHISTLN---IQLSDSKKKLQDFASTVEALEEGKKR 1396
Query: 786 EQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSG 845
Q+ +E L + E + + + Q+ L+ + L ++R QL L + R+
Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-QLVSNLEKKQRKF-- 1453
Query: 846 REQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATR---- 901
+Q L + + + + + +RA EA A+E A+ L A E EE R
Sbjct: 1454 -DQLLAEEKNISSKYADERDRA----EAEAREKETKALSLARALEEALEAKEELERTNKM 1508
Query: 902 LRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGEL-----AGLRQQII 956
L+ E E L S +V + + +LE + LE + + + E L EL A LR ++
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568
Query: 957 ATQEKASLDKELMAQKLVQAEREAQASLREQRAAHE-----EDLQRLQREKEAAWRELEA 1011
K +++L A+ E+ Q QR HE ED ++ + AA ++LE
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQL----QRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 1012 ERAQLQSQL------QREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS 1065
+ L+ Q + E + L +L+A+ ++ E+ + RDE A+ +++A S
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684
Query: 1066 LKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRA--- 1122
L E++ L E L + LE E + S S NAL E R L A
Sbjct: 1685 L-EADLMQLQEDLAAAERARKQADLEKEELAEELAS----SLSGRNALQDEKRRLEARIA 1739
Query: 1123 QREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
Q EE + + ++ R +Q + E R+ + E AR L R+ E +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 1183 KLRESQEGREVQ--------RQEAGELRRSLGEGAKEREA----LRRSNEELRSAVKKAE 1230
KL E + + + + +L + + A+E++A L++ +++L+ + + E
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1859
Query: 1231 SERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK 1290
ER K+A + KEQ E+ V +L+ L+E E ++L+R++
Sbjct: 1860 DER---KMAEQYKEQA----EKGNARVK----QLKRQLEEAEEESQRINANRRKLQRELD 1908
Query: 1291 MLDSENTRLGRELAELQGRL 1310
N +GRE+ L+ +L
Sbjct: 1909 EATESNEAMGREVNALKSKL 1928
Score = 186 bits (472), Expect = 2e-46
Identities = 261/1203 (21%), Positives = 499/1203 (41%), Gaps = 163/1203 (13%)
Query: 639 QRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDM 698
Q R EEE + + + + +++ +L++LE K S L +E L ++
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE----------KNLLQEQ 895
Query: 699 LQAEK---AEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDL 755
LQAE AE E + A + ELE + ++ A +D +L A + +AQ LDL
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 756 NRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ 815
QLEEE++A Q +L+LE+ A E ++ E
Sbjct: 956 EE---QLEEEEAARQ---------------------KLQLEKVTA----EAKIKKLEDEI 987
Query: 816 EALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALA 875
++ Q L ER L+E+++ L+ L+ E++ + L + + E++
Sbjct: 988 LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN-----------LTKLKNKHESMI 1036
Query: 876 KEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQ 935
E L V+L E+ + L + +L + + ++Q Q+A+L+ + + E E Q
Sbjct: 1037 SE---LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1093
Query: 936 ALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL 995
A L L E+A + +E +L Q+ + +ER A+ +Q+ E+L
Sbjct: 1094 AAL---ARLDDEIAQKNNALKKIRELEGHISDL--QEDLDSERAARNKAEKQKRDLGEEL 1148
Query: 996 QRLQREKE------AAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQER 1049
+ L+ E E A +EL A+R Q + L++ +E EA+ +E+ ++ A +E
Sbjct: 1149 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1208
Query: 1050 DEGLLLAESEKQQALSLKESEKTALSEK--LMGTRHSLATISLEMERQKR--DAQSRQEQ 1105
E L E K+ +L ++++T E L G L E+E +K+ +AQ ++ Q
Sbjct: 1209 TEQL---EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 1106 DRST------------VNALTSELRDLRAQREEA---AAAHAQEVRRLQEQARDLGKQRD 1150
+ + V+ L +E+ + EA A A++V L Q +D +
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 1151 SCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAK 1210
R+ + T+LR LE+ R+ L Q +L E E ++ + L L + K
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSL-------QDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 1211 EREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQE 1270
+ + + E L K+ + E +L E+K LE+ + + +E +L L
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD- 1437
Query: 1271 VERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESR--------R 1322
++ + L++ +R+ L +E + + A+ + R A E EKE++
Sbjct: 1438 ---NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR-AEAEAREKETKALSLARALE 1493
Query: 1323 ETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLD 1382
E L ++ L + L+ ++L ++ + + E +R L +EE K QL+
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM----KTQLE 1549
Query: 1383 HARGLELKLEAARAEAAELGLRLSAAEGR-AQGLEAELARVEVQRRAAEAQLGGLRSALR 1441
LE +L+A L + + A +G+ + L+A + E +RR + QL + L
Sbjct: 1550 E---LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606
Query: 1442 RGLGLGRAPSPAPRPVPG-----SPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATS 1496
+ A + + G D+ +G E + L+
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ------------- 1653
Query: 1497 PASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQL 1556
+++F +EL A+ RDE+ ++ +EA+ QL
Sbjct: 1654 --------------MKDFQRELEDARASRDEIFATAKENEKKAKSLEAD-------LMQL 1692
Query: 1557 QKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESEL 1616
Q+ +A +E AR+ D + ELA + E+R ++A LE L+ + +
Sbjct: 1693 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1752
Query: 1617 RASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDR- 1675
A +++ K +L + + +ES +LE Q + L +L + +
Sbjct: 1753 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1812
Query: 1676 EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEAL 1735
++ AL+ ++ L+ QV E +A Q + L K++E + D+ R + E
Sbjct: 1813 KSTIAALEAKIAQLEEQV---EQEAREKQAATKSLKQKDKKLKEILLQVEDE-RKMAEQY 1868
Query: 1736 AQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLR 1795
+ + N+ + L++ L E + Q + ++ L EA + + ++G +V L+
Sbjct: 1869 KEQAEKGNA---RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1925
Query: 1796 GEV 1798
++
Sbjct: 1926 SKL 1928
Score = 179 bits (454), Expect = 2e-44
Identities = 256/1138 (22%), Positives = 490/1138 (43%), Gaps = 122/1138 (10%)
Query: 797 QEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQ---ELEQA 853
QE Q E L+ ++ Q+ E +L L + SQL E+ L QL + E E+
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 854 RREAQRQVEALERAAREKEALAKEHAGLAVQLVAAER---------EGRTLSEEATR--L 902
R + + LE E EA +E QL A + E + EEA R L
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969
Query: 903 RLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKA 962
+LEK E + +++ ++ ++ + +L E + L LT LA +E+
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA--------EEEEK 1021
Query: 963 SLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEA-------AWRELEAERAQ 1015
+ + + K E + L+++ + +E L++L+R+ E +L+A+ A+
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 1016 LQSQLQREQEELLARLEAEKEELSEEIAALQQERD-EGLLLAESE----KQQALSLKESE 1070
L+ QL +++EEL A L +E++++ AL++ R+ EG + E ++ A + E +
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 1071 KTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVN-ALTSELRDLRAQREEAAA 1129
K L E+L + L +L+ +++ ++++EQ+ + + AL E R AQ +E
Sbjct: 1141 KRDLGEELEALKTELED-TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 1130 AHAQEVRRLQEQAR-------DLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
HAQ V L EQ +L K + + +E +L +LR+L A+ + + + +
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANED 1242
+++E Q + EL + + E E++ E K + SL +D
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 1243 KEQKLALLEEARTAVG-----KEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENT 1297
++ L EE R + ++ E R LQ+ +EA+ Q L R + L+ + +
Sbjct: 1320 TQELLQ--EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK---QNLERHISTLNIQLS 1374
Query: 1298 RLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEG 1357
++L + + E +K ++E L Q+ + A+ + + + Q++L +
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434
Query: 1358 EFRTRERRLLGSLEEARGTEKQQLDHARGLELKL----EAARAEAAELGLR-LSAAEGRA 1412
+ +R+L+ +LE+ + Q L + + K + A AEA E + LS A
Sbjct: 1435 DL-DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1493
Query: 1413 QGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGE 1472
+ LEA+ +E + +A++ L S+ + G + E S
Sbjct: 1494 EALEAK-EELERTNKMLKAEMEDLVSS---------------KDDVGKNVHEL--EKSKR 1535
Query: 1473 GLNSPSTLECSPGSQPPSPGPATSPASPDLDP--EAVRGALREFLQELRSAQRERDELRT 1530
L + + + AT A L+ +A++G +F ++L++ + +E R
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG---QFERDLQARDEQNEEKRR 1592
Query: 1531 QTSALNRQLAEMEAE-------RDSATSRARQLQKAVAESE-EARRSVDGRLSGVQA--E 1580
Q L RQL E E E R A + ++L+ + + E +A ++ GR ++ +
Sbjct: 1593 Q---LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 1649
Query: 1581 LALQEESVRRSERERRATLDQVATL----ERSLQATESELRASQEKISKMKANETKLEGD 1636
L Q + +R + RA+ D++ E+ ++ E++L QE ++ + + + +
Sbjct: 1650 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709
Query: 1637 KRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADS 1696
K L E L +S S L+ ++R LE + + L + + +A+ DRV +Q
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL 1769
Query: 1697 EVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKAL 1756
+ T + T ++ A ++E LR K+ + A+ S + + +
Sbjct: 1770 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI------ 1823
Query: 1757 TACEHDRQVLQERLD--AARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQ 1814
+ + QV QE + AA ++L + K+ + QV+ R + Q + +++Q
Sbjct: 1824 --AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1881
Query: 1815 LREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVE--RSALR 1870
L+ L + +E Q++ RR LQ L A EA REV +S LR
Sbjct: 1882 LKRQLEEAEEES-------QRINANRRKLQR---ELDEATESNEAMGREVNALKSKLR 1929
Score = 176 bits (446), Expect = 2e-43
Identities = 268/1168 (22%), Positives = 503/1168 (43%), Gaps = 175/1168 (14%)
Query: 883 VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARR----EQLEAEGQALL 938
+Q+ E E + +E + + ++ E L E++++ +QL + EQL+AE +
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 939 LAKETLTGELAGLRQQI--IATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQ 996
A+E + LA +Q++ I + +A L++E + +QAER+ A +Q EE L+
Sbjct: 905 EAEE-MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA---QQMLDLEEQLE 960
Query: 997 RLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLA 1056
E+EAA ++L+ E+ ++++++ ++E+L ++ + +LS+E LL
Sbjct: 961 ----EEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERK----------LLE 1005
Query: 1057 ESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSE 1116
E +L E E+ A + + +H LE+ R K++ +SRQE
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV-RLKKEEKSRQE------------ 1052
Query: 1117 LRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDA----RDG 1172
L L+ + E A+ +++ LQ Q +L Q ++ EEL+ L L+D +
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQ---LAKKEEELQAALARLDDEIAQKNNA 1109
Query: 1173 LR--RELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAE 1230
L+ REL L+E + R +A + +R LGE E EAL+ E+ + A
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE---ELEALKTELEDTLDST--AT 1164
Query: 1231 SERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK 1290
+ + K E K AL EE R+ + + Q VE E +L++ +R
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE----ELTEQLEQFKRAKA 1220
Query: 1291 MLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQR 1350
LD L +E A+L G L + +A++E + + LE QELQ
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHK-----------KKKLEAQVQELQSKCS 1269
Query: 1351 KLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEG 1410
+ E + +L +E G L+ A G +KL + A L +L +
Sbjct: 1270 DGERARAELNDKVHKLQNEVESVTG----MLNEAEGKAIKLAK---DVASLSSQLQDTQE 1322
Query: 1411 RAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGS 1470
Q + V + R E + L+ L + A+ +
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDE---------------------EMEAKQN 1361
Query: 1471 GEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRT 1530
E S ++ S + +T EA+ + F +E+ + ++ +E
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTV--------EALEEGKKRFQKEIENLTQQYEEKAA 1413
Query: 1531 QTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLS---GVQAELALQEES 1587
L + ++ E D ++ V+ E+ +R D L+ + ++ A + +
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 1588 VRRSERERRA-TLDQVATLERSLQATES-------------ELRASQEKISK-------- 1625
RE+ L LE +L+A E +L +S++ + K
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 1626 MKANETKLEGDKRRLKEV---LDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQAL 1682
+A ET++E K +L+E+ L A+E ++LE+ ++L+G+ +R D +A+ +
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER------DLQARDEQN 1587
Query: 1683 QDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASL 1742
+++ LQRQ+ + E +L ER ALA A + K+ G + L + S
Sbjct: 1588 EEKRRQLQRQLHEYET-----ELEDERKQRALA------AAAKKKLEGDLKDLELQADSA 1636
Query: 1743 NSTRDKNLHLQKALTACEHDRQVLQERLDAARQAL----SEARKQSSSLGEQVQTLRGEV 1798
R++ + + L A D Q E A+R + E K++ SL + L+ ++
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696
Query: 1799 ADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLE 1858
A E R +A+ + ++L E L A++L+ LQDE+R L+ R+ L+ +LE
Sbjct: 1697 AAAERARKQADLEKEELAEEL-------ASSLSGRNALQDEKRRLEARIAQLEE---ELE 1746
Query: 1859 AEKREVERSALRLEKDRVALRRTLDKVEREKLRSHE-DTVRLSAEKGRLDRTLTGAELEL 1917
E+ +E + R+ K + +++ E+ + + ++ R E+ + E+E
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806
Query: 1918 AEAQR---QIQQLEAQVVVLEQSHSPAQLEVDAQQQQL---ELQQEVERLRSAQAQTERT 1971
A + I LEA++ LE+ Q+E +A+++Q L+Q+ ++L+ Q E
Sbjct: 1807 AVKSKFKSTIAALEAKIAQLEE-----QVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861
Query: 1972 LEARERAHRQRVRGLEEQVSTLKGQLQQ 1999
+ E+ Q +G +V LK QL++
Sbjct: 1862 RKMAEQYKEQAEKG-NARVKQLKRQLEE 1888
Score = 134 bits (337), Expect = 9e-31
Identities = 207/937 (22%), Positives = 392/937 (41%), Gaps = 133/937 (14%)
Query: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKERE 1213
R+ EE++ + ED + +A+ +L+E ++ +E L+ L E E
Sbjct: 849 RQEEEMQAK----EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL---QAETE 901
Query: 1214 ALRRSNE-ELRSAVKKAESERI--SLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQE 1270
+ E +R A KK E E I ++ E++E + L+ R + ++ +L L+E
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 1271 VERSR-------LEARRELQELRRQMKMLDSENTRLGRELAELQGRLA-----LGERAEK 1318
E +R + A ++++L ++ ++D +N +L +E L+ R++ L E EK
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 1319 ESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEK 1378
+ L K + E M EL+V +K ++ E +R+L G +A +
Sbjct: 1022 A---------KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG---DASDFHE 1069
Query: 1379 QQLD-HARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLR 1437
Q D A+ ELK++ A+ E L AA R L+ E+A+ + +L G
Sbjct: 1070 QIADLQAQIAELKMQLAKKEE-----ELQAALAR---LDDEIAQKNNALKKIR-ELEGHI 1120
Query: 1438 SALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSP 1497
S L+ L RA R RD E TL+ + Q
Sbjct: 1121 SDLQEDLDSERAA----RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR------- 1169
Query: 1498 ASPDLDPEAVRGALREF-------LQELRSAQRER-DELRTQTSALNRQLAEMEAERDSA 1549
A + + ++ AL E +QE+R + +EL Q R A ++ + +
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 1550 TSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSL 1609
L + +A++ V+ + ++A++ + ER R D+V L+ +
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Query: 1610 QATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSR 1669
++ L ++ K K+ + L + +E+L + + + + R LE E +
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 1670 LGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVR 1729
L + Q L+ + +L Q++DS+ K TVE L EE + + ++
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL-------EEGKKRFQKEIE 1402
Query: 1730 GLTEALAQSSASLNSTRDKNLHLQKAL----TACEHDRQV---LQERLDAARQALSEARK 1782
LT+ + +A+ + LQ+ L ++ RQ+ L+++ Q L+E +
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 1783 QSSSLGEQVQTLRGEVADLEL----------QRVEAEGQLQQLREVLRQRQEGEAAALNT 1832
SS ++ E + E + +EA+ +L++ ++L+ E ++ +
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522
Query: 1833 VQK----LQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALR-------RT 1881
V K L+ +R L+ ++ ++ L +LE E + E + LRLE + AL+ +
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582
Query: 1882 LDKVEREKLRS-----HEDTVRL----------SAEKGRLDRTLTGAELEL-------AE 1919
D+ EK R HE L +A K +L+ L EL+ E
Sbjct: 1583 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1642
Query: 1920 AQRQIQQLEAQVVVLEQSHSPAQLEVDA--------QQQQLELQQEVERLRSAQAQTERT 1971
A +Q+++L+AQ+ ++ A+ D +++ L+ ++ +L+ A ER
Sbjct: 1643 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER- 1701
Query: 1972 LEARERAHRQRVRGLEEQVSTLKGQ--LQQELRRSSA 2006
AR++A ++ EE S+L G+ LQ E RR A
Sbjct: 1702 --ARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1736
Score = 47.4 bits (111), Expect = 1e-04
Identities = 50/225 (22%), Positives = 101/225 (44%), Gaps = 41/225 (18%)
Query: 78 SLQEENQLLQQELSRVEDLLAQSRAERDELAIKY-------NAVSE----------RLEQ 120
SL+ + LQ++L+ E Q+ E++ELA + NA+ + +LE+
Sbjct: 1684 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1743
Query: 121 ALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGK- 179
L E G +E R VR++ + QL E A+ R Q + +Q+ + + L+ K
Sbjct: 1744 ELEEEQGNMEAMSDR--VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL 1801
Query: 180 --------------ILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEE 225
I + + ++LE+Q+ + + E + + + L+ L+++E+E
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861
Query: 226 ----QQRSASLAQVNA---MLREQLDQAGSANQALSEDIRKVTND 263
+Q + NA L+ QL++A +Q ++ + RK+ +
Sbjct: 1862 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1906
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 204 bits (519), Expect = 7e-52
Identities = 279/1159 (24%), Positives = 481/1159 (41%), Gaps = 131/1159 (11%)
Query: 823 PTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLA 882
P LR +Q +E+LA L +L G L A + Q E +EK LA +
Sbjct: 887 PLLRS--AQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQ 944
Query: 883 VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKE 942
L AE L + +L + + L L + + A L ARR +LE E
Sbjct: 945 DNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDE--------- 995
Query: 943 TLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQA------SLREQRAAHEEDLQ 996
T+ K +D + L +AE+E QA +L E+ AA +E +
Sbjct: 996 --------------CTELKKDIDD--LKLTLAKAEKEKQATENKVKNLTEEMAALDESVA 1039
Query: 997 RLQREKEA-------AWRELEAERAQLQS------QLQREQEELLARLEAEKE-ELSEEI 1042
RL +EK+A A +L+AE ++ + +L+++ E+L LE EK+ + E
Sbjct: 1040 RLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTER 1099
Query: 1043 AALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSR 1102
A + E D L Q++++ +K L EKL L+ +SL +E D Q
Sbjct: 1100 AKRKLEGDLKL------TQESVADAAQDKQQLEEKLKKKDSELSQLSLRVE----DEQLL 1149
Query: 1103 QEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQ 1162
Q + + L + +L + E AA A+ + KQR RE EEL +
Sbjct: 1150 GAQMQKKIKELQARAEELEEELEAERAARAR-----------VEKQRAEAARELEELSER 1198
Query: 1163 LRLLEDA----RDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRS 1218
L A R+G R+ E R RE +E LRR EGA E L
Sbjct: 1199 LEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAE---LGEQ 1255
Query: 1219 NEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEA 1278
+ L+ +K E E+ L++ +D + L A+ + K L E + E
Sbjct: 1256 VDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEEL 1315
Query: 1279 RRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASL 1338
+R+L + Q L +E+ L R L E + ++ R + + + LR++L + +
Sbjct: 1316 QRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAK 1375
Query: 1339 EVMRQELQVAQ------RKLQEQEGEFRTRERRLL--GSLEEARGTEKQQLDHARGLELK 1390
+ +Q + R+ E+E E + +RLL + E A+ K + D + E +
Sbjct: 1376 SALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTE-E 1434
Query: 1391 LEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAP 1450
LE A+ +L LRL AE + A+ + +E + + + + L R A
Sbjct: 1435 LEEAK---KKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAAL 1491
Query: 1451 SPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGA 1510
R + A E + LE +Q S G T E A
Sbjct: 1492 DKKQRHL-----ERALEERRRQEEEMQRELE---AAQRESRGLGTELFRLRHGHEEALEA 1543
Query: 1511 LREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSV 1570
L +E ++ Q E +L Q S + + E+E + + ++Q A+ E+E A
Sbjct: 1544 LETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELE 1603
Query: 1571 DGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKAN- 1629
+ + +Q EL+ + V R E+ ++ A L R+ Q L+AS + ++ +
Sbjct: 1604 ETKTLRIQLELSQVKAEVDRKLAEKD---EECANLRRNHQRAVESLQASLDAETRARNEA 1660
Query: 1630 ---ETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRV 1686
+ K+EGD L+ L + + + + R ++ +L+ + G + + A L ++
Sbjct: 1661 LRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQA 1720
Query: 1687 DSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEAL----AQSSASL 1742
+L+R +A L +E L AL + E S ++ TE L +Q++ L
Sbjct: 1721 QALER-------RASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLL 1773
Query: 1743 NSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLE 1802
N + L + E Q +E + A++A+++A + L ++ T A LE
Sbjct: 1774 NQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDT----SAHLE 1829
Query: 1803 LQRVEAEGQLQQLREVLRQRQEGEAAAL----NTVQKLQDERRLLQERLGSLQR----AL 1854
+ E Q +RE+ + +E E AAL VQKL+ + R L+ L + Q+ AL
Sbjct: 1830 RMKKTLE---QTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEAL 1886
Query: 1855 AQLEAEKREVERSALRLEKDRVALRRTLDKVER--EKLRSHEDTVRLSAEKGRLD-RTLT 1911
+ +R V+ A + E+DR L R D V++ K++S++ + ++ +
Sbjct: 1887 KGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYR 1946
Query: 1912 GAELELAEAQRQIQQLEAQ 1930
A+ EL +A+ + E Q
Sbjct: 1947 KAQHELDDAEERADMAETQ 1965
Score = 199 bits (506), Expect = 2e-50
Identities = 277/1122 (24%), Positives = 493/1122 (43%), Gaps = 120/1122 (10%)
Query: 699 LQAEKAEVAEALTKAEAGRVELE---LSMTK--------LRAEEASLQDSLSKLSALNES 747
L+AE + AL AEA R ELE +S+T+ L+AE+ +L D+ + L +S
Sbjct: 901 LRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKS 960
Query: 748 LAQDKLDLNRLVAQLEEEKSA---LQGRQRQAEQEATVAREEQERLEELRLEQEVARQGL 804
Q + + L +LE+E+ L R+R+ E E T +++ + L+ + E +Q
Sbjct: 961 KVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQAT 1020
Query: 805 EGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQE---LEQARREAQRQV 861
E ++ + AL++ + L E+ LQE Q L E L +A+ ++QV
Sbjct: 1021 ENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQV 1080
Query: 862 EALERAAREKEALAKE----------HAGLAVQLVAAEREGRTLSEEATR---------- 901
E LE + +++ L + L + VA + + EE +
Sbjct: 1081 EDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLS 1140
Query: 902 LRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEK 961
LR+E E L G+ ++Q+++ +L+AR E+LE E +A A R ++ + +
Sbjct: 1141 LRVEDEQLLGA--QMQKKIKELQARAEELEEELEAERAA-----------RARVEKQRAE 1187
Query: 962 ASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQ 1021
A+ + E ++++L +A A A RE E +L RL+RE E A EA A L+
Sbjct: 1188 AARELEELSERLEEA-GGASAGQREGCRKREAELGRLRRELEEAALRHEATVA----ALR 1242
Query: 1022 REQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGT 1081
R+Q E A L + + L L++E+ E + + +L ++ +A EKL T
Sbjct: 1243 RKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASA--EKLCRT 1300
Query: 1082 ---RHSLATISL-EMERQKRDA---QSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQE 1134
+ S A I + E++RQ DA + R + + ++ L E L +Q A AQ
Sbjct: 1301 YEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQS 1360
Query: 1135 VRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREV- 1193
+ L+ Q + K + + + LR LL + + E QR L S+ EV
Sbjct: 1361 LEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLL--SKANAEVA 1418
Query: 1194 ---QRQEAGELRRSLG-EGAKEREALR--RSNEELRSAVKKAES-ERISLKLANEDKEQK 1246
+ EA ++R+ E AK++ ALR + E + +A K S E+ L+L E ++
Sbjct: 1419 QWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVT 1478
Query: 1247 LALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAEL 1306
L LE A +A A L + +ER+ E RR+ +E++R+++ E+ LG EL L
Sbjct: 1479 LE-LERATSA----AAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRL 1533
Query: 1307 QGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRL 1366
+ A + +RE L++ + + + + +Q ++ + EGE + +
Sbjct: 1534 RHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGE----KSEI 1589
Query: 1367 LGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELAR-VEVQ 1425
+LEEA G +L+ + L ++LE ++ + AE+ +L+ + L R VE
Sbjct: 1590 QAALEEAEGA--LELEETKTLRIQLELSQVK-AEVDRKLAEKDEECANLRRNHQRAVESL 1646
Query: 1426 RRAAEAQLGGLRSALR-----------RGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGL 1474
+ + +A+ ALR L LG A A + A + G
Sbjct: 1647 QASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGR 1706
Query: 1475 NSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSA 1534
+ L Q + S + +L E +R AL + + R A++E E + +
Sbjct: 1707 DEEQRLAAELHEQAQALERRASLLAAEL--EELRAALEQGERSRRLAEQELLEATERLNL 1764
Query: 1535 LNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERE 1594
L+ Q + ++ + QL V E+ + RR + + + A+ E +++ E++
Sbjct: 1765 LHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKK-EQD 1823
Query: 1595 RRATLDQV-ATLERSLQATESEL-RASQEKISKMKANETKLEGDKRRLKEVLDASESRTV 1652
A L+++ TLE++++ ++ L A Q + K KLE R L+ LDA + +
Sbjct: 1824 TSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHA 1883
Query: 1653 -------KLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQL 1705
K E + + L + + R L+ + LQ +V S +RQ ++E +A T
Sbjct: 1884 EALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANT--- 1940
Query: 1706 TVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRD 1747
LAK +++ L D A Q++ TRD
Sbjct: 1941 -------NLAKYRKAQHELDDAEERADMAETQANKLRARTRD 1975
Score = 190 bits (483), Expect = 1e-47
Identities = 273/1157 (23%), Positives = 474/1157 (40%), Gaps = 215/1157 (18%)
Query: 567 EEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQ--------- 617
EE+L LR + G A A+ + Q L + +++EK++LA LQ Q
Sbjct: 895 EEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERC 954
Query: 618 ------------QAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSH 665
+ +EL + E + +L +R +LE+E + +D ++ L ++
Sbjct: 955 HLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAE 1014
Query: 666 RQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMT 725
++ + E K L +E+ + E+++R T ++ LQ E + A +AE RV L+
Sbjct: 1015 KEKQATENKVKNLTEEMAALDESVARLTKEKKALQ-EAHQQALGDLQAEEDRVS-ALTKA 1072
Query: 726 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVARE 785
KLR E+ ++ L SL Q+K +L E K L+G + ++ A +
Sbjct: 1073 KLRLEQ--------QVEDLECSLEQEK----KLRMDTERAKRKLEGDLKLTQESVADAAQ 1120
Query: 786 EQERLEE-------------LRLEQE-VARQGLEGSLRVAEQAQEALEQQLPTLRHERSQ 831
++++LEE LR+E E + ++ ++ + E LE++L R R++
Sbjct: 1121 DKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARAR 1180
Query: 832 LQEQLAQLSRQLSGREQELEQA------RREAQRQVEA-LERAAREKEALAKEH------ 878
+++Q A+ +R+L + LE+A +RE R+ EA L R RE E A H
Sbjct: 1181 VEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAA 1240
Query: 879 ---------AGLAVQLVAAEREGRTLSEEATRLRLEKEALEGS----------------- 912
A L Q+ + +R + L +E + LR+E + L +
Sbjct: 1241 LRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRT 1300
Query: 913 -----------LFEVQRQLAQLEARREQLEAEG---QALLLAKETLTGELAGLRQQIIAT 958
+ E+QRQLA +R +L+ E LL KE L +L+ R + +A
Sbjct: 1301 YEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLS--RGKALAA 1358
Query: 959 QEKASLDKELMAQKLVQAEREAQASLRE--QRAAHEEDLQRLQREKEAAWRELEAERAQL 1016
Q L ++L + E +A+++L Q H+ DL R Q E+EA E +AE +L
Sbjct: 1359 QSLEELRRQL------EEESKAKSALAHAVQALRHDCDLLREQHEEEA---EAQAELQRL 1409
Query: 1017 QSQLQREQEELLARLEA-------EKEELSEEIAALQQERDEGLLLAESE---------- 1059
S+ E + ++ EA E EE +++A QE +EG+ A ++
Sbjct: 1410 LSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLR 1469
Query: 1060 ---KQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSE 1116
+ + ++L+ T+ + L + L E RQ+ + Q E + L +E
Sbjct: 1470 LQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTE 1529
Query: 1117 LRDLRAQREEAAAA---HAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGL 1173
L LR EEA A +E + LQE+ DL Q + +EL + LE + +
Sbjct: 1530 LFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEI 1589
Query: 1174 RRELLEAQRKLRESQEGREVQ-----RQEAGELRRSLGEGAKEREALRRSN----EELRS 1224
+ L EA+ L E +E + ++ Q E+ R L E +E LRR++ E L++
Sbjct: 1590 QAALEEAEGAL-ELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQA 1648
Query: 1225 AV-----KKAESERISLKLANEDKEQKLALLEEARTAVGKEAGE--LRTGLQEVERSRLE 1277
++ + E+ R+ K+ + + +L L R A +A ++ L+E + R E
Sbjct: 1649 SLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDE 1708
Query: 1278 ARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEAS 1337
+R EL Q + L+ + L EL EL+ L GER+ + + +E L +RL
Sbjct: 1709 EQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERL------ 1762
Query: 1338 LEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAE 1397
L Q ++++L L + G ++ R E K + A +
Sbjct: 1763 ------------NLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITD 1810
Query: 1398 AAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPV 1457
AA + L + + LE +E R +A+L A RG
Sbjct: 1811 AAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRG-------------- 1856
Query: 1458 PGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQE 1517
G LE +LD E + A E L+
Sbjct: 1857 ---------------GKKQVQKLEAK-----------VRELEAELDAEQKKHA--EALKG 1888
Query: 1518 LRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGV 1577
+R +R EL Q + LA M+ D S+ + ++ E+E+ + +
Sbjct: 1889 VRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKA 1948
Query: 1578 QAELALQEESVRRSERE 1594
Q EL EE +E +
Sbjct: 1949 QHELDDAEERADMAETQ 1965
Score = 181 bits (460), Expect = 5e-45
Identities = 278/1155 (24%), Positives = 482/1155 (41%), Gaps = 172/1155 (14%)
Query: 760 AQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALE 819
AQ EEE +AL+ R A +++ LEE + + L L+ + E
Sbjct: 892 AQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAE 951
Query: 820 QQLPTLRHERSQLQEQLAQLSRQ----------LSGREQELEQARREAQRQVE----ALE 865
++ L + QL+ ++ +LS + L+ R ++LE E ++ ++ L
Sbjct: 952 ERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLA 1011
Query: 866 RAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEA 925
+A +EK+A + L ++ A L E RL EK+AL+ + Q+ L L+A
Sbjct: 1012 KAEKEKQATENKVKNLTEEMAA-------LDESVARLTKEKKALQEA---HQQALGDLQA 1061
Query: 926 RREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKL---VQAEREAQA 982
+++ A +A L ++ + L Q ++K +D E +KL ++ +E+ A
Sbjct: 1062 EEDRVSALTKAKLRLEQQVEDLECSLEQ-----EKKLRMDTERAKRKLEGDLKLTQESVA 1116
Query: 983 SLREQRAAHEEDLQRLQREKEAAWRELEAERAQ-LQSQLQREQEELLARLEAEKEELSEE 1041
+ + EE L++ ++ E + L E Q L +Q+Q++ +EL AR E +EEL E
Sbjct: 1117 DAAQDKQQLEEKLKK--KDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAE 1174
Query: 1042 IAALQQERDEGLLLAESEKQQALSLKESEKTALSEKL-------MGTRHSLATISLEMER 1094
AA A EKQ+A + +E E+ LSE+L G R E+ R
Sbjct: 1175 RAA----------RARVEKQRAEAARELEE--LSERLEEAGGASAGQREGCRKREAELGR 1222
Query: 1095 QKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLR 1154
+R+ + + +TV A LR ++ E AA ++V LQ + L K++
Sbjct: 1223 LRRELEEAALRHEATVAA-------LRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRM 1275
Query: 1155 EAEELRTQL--------------RLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGE 1200
E ++L + R ED + ++ E QR+L ++ R + E+GE
Sbjct: 1276 EVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGE 1335
Query: 1201 LRRSLGE--------------GAKEREALRRSNEE---LRSAVKKA-ESERISLKLANED 1242
L R L E A+ E LRR EE +SA+ A ++ R L E
Sbjct: 1336 LSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQ 1395
Query: 1243 KEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKM-LDSENTRLGR 1301
E++ E + + K E+ + E ++ EL+E ++++ + L +
Sbjct: 1396 HEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEA 1455
Query: 1302 ELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRT 1361
A+ R + ES TL L +R A+L+ ++ L+ A + + QE E
Sbjct: 1456 ANAKCSSLEKAKLRLQTESEDVTLEL-ERATSAAAALDKKQRHLERALEERRRQEEEM-- 1512
Query: 1362 RERRLLGSLEEAR--GTEKQQLDHARGLELK-LEAARAEAAEL--------------GLR 1404
+R L + E+R GTE +L H L+ LE + E L G
Sbjct: 1513 -QRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKS 1571
Query: 1405 LSAAEGRAQGLEAELARVEVQRRAAEAQLG-GLRSALRRGLGLGRAPSPAPRPVPGSPAR 1463
+ E + LE E + ++ AE L LR L L + + R +
Sbjct: 1572 IQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKL------ 1625
Query: 1464 DAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLD-PEAVRGALREFLQELRSAQ 1522
AE E N + + S S T + L + + G L + +L A
Sbjct: 1626 ---AEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHAT 1682
Query: 1523 RERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELA 1582
R+ E + T + QL E +A RD + Q+ AE E ++++ R S + AEL
Sbjct: 1683 RQATEAQAATRLMQAQLKEEQAGRD-------EEQRLAAELHEQAQALERRASLLAAEL- 1734
Query: 1583 LQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKE 1642
E RA L+Q ERS + E EL + E+++ + + T L K++L+
Sbjct: 1735 ----------EELRAALEQG---ERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEA 1781
Query: 1643 VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGT 1702
L + +RR E ++++ ++D A+ L+ D+ A E T
Sbjct: 1782 DLAQLSGEVEEAAQERREAE---EKAKKAITDAAMMAEELKKEQDT----SAHLERMKKT 1834
Query: 1703 LQLTVERLNGALAKVEESEGAL----RDKVRGLTEALAQSSASLNSTRDKNLHLQKALTA 1758
L+ TV L A++EE+E A + +V+ L + + A L++ + K+ K +
Sbjct: 1835 LEQTVRELQ---ARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVR- 1890
Query: 1759 CEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQ----LQQ 1814
+H+R+V + A E RK + + + V L+ +V + Q EAE Q L +
Sbjct: 1891 -KHERRVKELAYQA-----EEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAK 1944
Query: 1815 LREVLRQRQEGEAAA 1829
R+ + + E A
Sbjct: 1945 YRKAQHELDDAEERA 1959
Score = 174 bits (441), Expect = 8e-43
Identities = 274/1112 (24%), Positives = 467/1112 (41%), Gaps = 130/1112 (11%)
Query: 61 QPESPVLLPATEMASLL-----SLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVS 115
Q E L A E LL L+ + + L + L E++ A A R +L + +
Sbjct: 941 QAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELK 1000
Query: 116 ERLEQA-LRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQ 174
+ ++ L L E E Q V+ E L E A ++ +A QE Q+ +Q
Sbjct: 1001 KDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQ 1060
Query: 175 RLQGKILQYKKRCSELEQQL--LERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASL 232
+ ++ K LEQQ+ LE S E E++ DTE ++ ++L +E A
Sbjct: 1061 AEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADA-- 1118
Query: 233 AQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNE 292
AQ L E+L + S LS + + +K+++ +A EE A E
Sbjct: 1119 AQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEA----E 1174
Query: 293 HSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELA--RTSRAVQEAGLG-LSTGLRLA 349
+ + +Q R E++ +ER L + GG A R +EA LG L L A
Sbjct: 1175 RAARARVEKQRAEAAR---ELEELSER-LEEAGGASAGQREGCRKREAELGRLRRELEEA 1230
Query: 350 ESRAEAAL----EKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLA 405
R EA + KQA A+L EQ+ + L +++ + ++ DL+A V L A
Sbjct: 1231 ALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRA 1290
Query: 406 VKRLEKQ-NLEKDQVN--KDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLS 462
EK +DQ++ K E+L+ + ++ L+TE GE L + L + + ++S
Sbjct: 1291 KASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGE-LSRLLEE-KECLIS 1348
Query: 463 DSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPAC-----SD 517
G L+ SL L Q +S+ R +
Sbjct: 1349 QLSRGKALAAQ---------SLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEE 1399
Query: 518 SSTLALIHSALHKRQLQVQDMRGRYEAS--------QDLLGTLRKQLSDSESERRALEEQ 569
+ A + L K +V R +YEA ++ L +L ++E A +
Sbjct: 1400 AEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAK 1459
Query: 570 LQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKL 629
L ED E++R SA L +++ +L +L+ ++Q EE+++E E
Sbjct: 1460 CSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAA 1519
Query: 630 QAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREAL 689
Q L + RL E+A++ ++RE + ++ L + S+ K + E+ +
Sbjct: 1520 QRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKT- 1578
Query: 690 SRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLA 749
+ L+ EK+E+ AL +AE G +ELE + T LR + L+
Sbjct: 1579 ------KKALEGEKSEIQAALEEAE-GALELEETKT-LR---------------IQLELS 1615
Query: 750 QDKLDLNRLVAQLEEEKSALQGRQRQAEQ--EATVAREEQERLEELRLEQEVARQGLEGS 807
Q K +++R +A+ +EE + L+ ++A + +A++ E + R E LRL++++ +
Sbjct: 1616 QVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLE 1675
Query: 808 LRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERA 867
L++ ++A E Q T + AQL + +GR++E ++ E Q +ALER
Sbjct: 1676 LQLGHATRQATEAQAAT--------RLMQAQLKEEQAGRDEE-QRLAAELHEQAQALERR 1726
Query: 868 AREKEALAKEHAGLAVQLVAAEREGRTLSEEA--------------TRLRLEKEALEGSL 913
A LA E L L ER R +E T L +K+ LE L
Sbjct: 1727 A---SLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADL 1783
Query: 914 FEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKL 973
++ ++ EA +E+ EAE + AK+ +T A + + + ++ S E M + L
Sbjct: 1784 AQLSGEVE--EAAQERREAEEK----AKKAITD--AAMMAEELKKEQDTSAHLERMKKTL 1835
Query: 974 VQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQ------REQEEL 1027
Q RE QA L E A ++ ++ EA RELEAE Q + R+ E
Sbjct: 1836 EQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERR 1895
Query: 1028 LARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLAT 1087
+ L + EE + +A +Q D+ +S K+Q ++ T L+ K +H L
Sbjct: 1896 VKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLA-KYRKAQHEL-- 1952
Query: 1088 ISLEMERQKRDAQSRQEQDRSTVNALTSELRD 1119
DA+ R + + N L + RD
Sbjct: 1953 ---------DDAEERADMAETQANKLRARTRD 1975
Score = 169 bits (428), Expect = 3e-41
Identities = 287/1183 (24%), Positives = 491/1183 (41%), Gaps = 190/1183 (16%)
Query: 872 EALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEA------ 925
E L + + L+ A GR + E RL ++AL F +Q + A
Sbjct: 823 EELRDQRLAKVLTLLQARSRGRLMRLEYQRLLGGRDAL----FTIQWNIRAFNAVKNWSW 878
Query: 926 -----------RREQLEAEGQALLLAKETLTGELAGL---RQQIIATQEKASLDKELMAQ 971
R Q E E AL L G LA RQ++ T + +K +A
Sbjct: 879 MKLFFKMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLAL 938
Query: 972 KLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARL 1031
+L QAE++ A EE L + K +LE + +L +L+ ++EE+ A L
Sbjct: 939 QL-QAEQDNLADA-------EERCHLLIKSKV----QLEGKVKELSERLE-DEEEVNADL 985
Query: 1032 EAEKEELSEEIAALQQERDE-GLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISL 1090
A + +L +E L+++ D+ L LA++EK EK A K+ +A +
Sbjct: 986 AARRRKLEDECTELKKDIDDLKLTLAKAEK---------EKQATENKVKNLTEEMAALDE 1036
Query: 1091 EMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRD 1150
+ R ++ ++ QE + + L +E E+ +A + RL++Q DL
Sbjct: 1037 SVARLTKEKKALQEAHQQALGDLQAE--------EDRVSALTKAKLRLEQQVEDL----- 1083
Query: 1151 SCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAK 1210
C E E+ LR + A+RKL EG QE S+ + A+
Sbjct: 1084 ECSLEQEKK-------------LRMDTERAKRKL----EGDLKLTQE------SVADAAQ 1120
Query: 1211 EREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQ- 1269
+++ +L +KK +SE L L ED++ A +++ + A EL L+
Sbjct: 1121 DKQ-------QLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEA 1173
Query: 1270 ------EVERSRLEARRELQELRRQMKMLD--SENTRLGRELAELQ-GRLALG-ERAEKE 1319
VE+ R EA REL+EL +++ S R G E + GRL E A
Sbjct: 1174 ERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALR 1233
Query: 1320 SRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQ 1379
LR++ +G A L LQ ++KL++++ E R L ++E +
Sbjct: 1234 HEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKAS 1293
Query: 1380 QLDHARGLELKLEAARAEAAELGLRLSAAE---GRAQGLEAELARVEVQRRAAEAQLGGL 1436
R E +L A+ + EL +L+ A GR Q EL+R+ ++ L
Sbjct: 1294 AEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKEC-------L 1346
Query: 1437 RSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATS 1496
S L RG L A S E L E S + A
Sbjct: 1347 ISQLSRGKAL--------------------AAQSLEELRRQLEEESKAKS---ALAHAVQ 1383
Query: 1497 PASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQL-AEMEAERDSATSRARQ 1555
D D LRE +E AQ E L ++ +A Q ++ EA+ T +
Sbjct: 1384 ALRHDCD------LLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEE 1437
Query: 1556 LQKAVA----ESEEARRSVDGRLSGVQ-AELALQEESVRRSERERRATLDQVATLERSLQ 1610
+K +A E+EE + + + S ++ A+L LQ ES + RAT A L++ +
Sbjct: 1438 AKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERAT-SAAAALDKKQR 1496
Query: 1611 ATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRL 1670
E RA +E+ + + + +LE +R ESR + EL R L + +
Sbjct: 1497 HLE---RALEERRRQEEEMQRELEAAQR---------ESRGLGTELFR--LRHGHEEALE 1542
Query: 1671 GLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKV----EESEGALRD 1726
L + + + LQ+ + L QV+ S L+ T + L G +++ EE+EGAL
Sbjct: 1543 ALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALEL 1602
Query: 1727 KVRG-------LTEALAQSSASLNSTRDKNLHLQKALTACEHDRQV--LQERLDAARQAL 1777
+ L++ A+ L ++ +L++ H R V LQ LDA +A
Sbjct: 1603 EETKTLRIQLELSQVKAEVDRKLAEKDEECANLRR-----NHQRAVESLQASLDAETRAR 1657
Query: 1778 SEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQ 1837
+EA + + + L ++ Q EA+ + ++ L++ Q G +L
Sbjct: 1658 NEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELH 1717
Query: 1838 DERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV 1897
++ + L+ R L L +L A + ERS R+A + L+ ER L H
Sbjct: 1718 EQAQALERRASLLAAELEELRAALEQGERSR------RLAEQELLEATERLNL-LHSQNT 1770
Query: 1898 RLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQE 1957
L +K +L+ L E+ EA ++ ++ E + +++ + A + + +++ +
Sbjct: 1771 GLLNQKKKLEADLAQLSGEVEEAAQERREAEEKA---KKAITDAAMMAEELKKEQDTSAH 1827
Query: 1958 VERLRSAQAQTERTLEAR-ERAHRQRVRGLEEQVSTLKGQLQQ 1999
+ER++ QT R L+AR E A + +RG ++QV L+ ++++
Sbjct: 1828 LERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRE 1870
Score = 110 bits (275), Expect = 1e-23
Identities = 206/896 (22%), Positives = 358/896 (39%), Gaps = 108/896 (12%)
Query: 1163 LRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEEL 1222
L +LE+ RD + L + L+ GR ++ E +R LG R+AL +
Sbjct: 819 LGVLEELRD---QRLAKVLTLLQARSRGRLMRL----EYQRLLGG----RDALFTIQWNI 867
Query: 1223 RS--AVKKAESERISLK----LANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRL 1276
R+ AVK ++ K L + E++LA L + QE+E + +
Sbjct: 868 RAFNAVKNWSWMKLFFKMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHV 927
Query: 1277 EARRELQELRRQMK-----MLDSENT--RLGRELAELQGRLA-LGERAEKESR-RETLGL 1327
+E +L Q++ + D+E L + +L+G++ L ER E E L
Sbjct: 928 SITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAA 987
Query: 1328 RQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGL 1387
R+R L+ E + +++++ + L + E E + E ++ EE LD +
Sbjct: 988 RRRKLEDECT--ELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAA-----LDESVAR 1040
Query: 1388 ELKLEAARAEAAELGLR-LSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGL 1446
K + A EA + L L A E R L R+E Q+ L +L + L
Sbjct: 1041 LTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLE-------QQVEDLECSLEQEKKL 1093
Query: 1447 GRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEA 1506
A R + G E + LE + S S ++ E
Sbjct: 1094 RMDTERAKRKLEGD--LKLTQESVADAAQDKQQLE----EKLKKKDSELSQLSLRVEDEQ 1147
Query: 1507 VRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEA 1566
+ GA + ++++ Q +EL + A A +E +R A AR+L++ EEA
Sbjct: 1148 LLGA--QMQKKIKELQARAEELEEELEAERAARARVEKQRAEA---ARELEELSERLEEA 1202
Query: 1567 RRSVDGRLSGV---QAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKI 1623
+ G+ G +AEL + + AT VA L R +EL E++
Sbjct: 1203 GGASAGQREGCRKREAELGRLRRELEEAALRHEAT---VAALRRKQAEGAAELG---EQV 1256
Query: 1624 SKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQ 1683
++ KLE +K L+ +D + L + S E +L R+ E Q +
Sbjct: 1257 DSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAE-KLCRTY------EDQLSEAK 1309
Query: 1684 DRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRG---LTEALAQSSA 1740
+V+ LQRQ+AD+ + G LQ L+ L EE E + RG ++L +
Sbjct: 1310 IKVEELQRQLADASTQRGRLQTESGELSRLL---EEKECLISQLSRGKALAAQSLEELRR 1366
Query: 1741 SLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVAD 1800
L L A+ A HD +L+E+ + +A +E ++ S +V R +
Sbjct: 1367 QLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEA 1426
Query: 1801 LELQRVEA-EGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQER-------LGSLQR 1852
+QR E E ++L L++ +EG AA L+ + LQ L
Sbjct: 1427 DAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATS 1486
Query: 1853 ALAQLEAEKREVERSALRLEKDRVALRRTLDKVERE---------KLR-SHEDTVR---- 1898
A A L+ ++R +ER+ + ++R L+ +RE +LR HE+ +
Sbjct: 1487 AAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALET 1546
Query: 1899 LSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV 1958
L E L ++ +++ + + IQ+LE LE S Q ++ + LEL++
Sbjct: 1547 LKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETK 1606
Query: 1959 E-----RLRSAQAQTERTLEARE-------RAHRQRVRGLEEQVSTLKGQLQQELR 2002
L +A+ +R L ++ R H++ V L+ + + LR
Sbjct: 1607 TLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALR 1662
Score = 78.2 bits (191), Expect = 8e-14
Identities = 82/359 (22%), Positives = 164/359 (45%), Gaps = 14/359 (3%)
Query: 1650 RTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVER 1709
R+ + E + +L EL+ R L+ EA+ Q L++ S+ ++ D LQL E+
Sbjct: 890 RSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDL-----ALQLQAEQ 944
Query: 1710 LNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQER 1769
N A A+ E ++ KV+ L + + S L + N L E + L++
Sbjct: 945 DNLADAE-ERCHLLIKSKVQ-LEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKD 1002
Query: 1770 LDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAA 1829
+D + L++A K+ + +V+ L E+A L+ + + L+E +Q A
Sbjct: 1003 IDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAE 1062
Query: 1830 LNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREK 1889
+ V L + L++++ L+ +L Q + + + ER+ +LE D + ++ ++K
Sbjct: 1063 EDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDK 1122
Query: 1890 LRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQ 1949
+ E + +E +L + +L A+ Q++I++L+A+ LE+ +LE +
Sbjct: 1123 QQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEE-----ELEAERAA 1177
Query: 1950 QQLELQQEVERLRSAQAQTERTLEA--RERAHRQRVRGLEEQVSTLKGQLQQELRRSSA 2006
+ +Q E R + +ER EA R+ R E ++ L+ +L++ R A
Sbjct: 1178 RARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEA 1236
Score = 51.2 bits (121), Expect = 1e-05
Identities = 65/257 (25%), Positives = 107/257 (41%), Gaps = 58/257 (22%)
Query: 1803 LQRVEAEGQLQQLREVLR-----------QRQEGEAAALNTVQ----------------- 1834
L+ +AE +L LR LR +RQE E ++ Q
Sbjct: 889 LRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLA 948
Query: 1835 --------------KLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRR 1880
+L+ + + L ERL + A L A +R++E L+KD L+
Sbjct: 949 DAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKL 1008
Query: 1881 TLDKVEREKLRSHEDTVRLSAEKGRLDRT---LTGAELELAEAQRQ----IQQLEAQVVV 1933
TL K E+EK + L+ E LD + LT + L EA +Q +Q E +V
Sbjct: 1009 TLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSA 1068
Query: 1934 LEQSHSPAQLEVDAQQQQLELQQEVE-RLRSAQAQTERTLEARERAHRQRVRGLEEQVST 1992
L + A+L ++ Q + LE E E +LR + +R LE + ++ V +
Sbjct: 1069 L----TKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQD--- 1121
Query: 1993 LKGQLQQELRRSSAPFS 2009
K QL+++L++ + S
Sbjct: 1122 -KQQLEEKLKKKDSELS 1137
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 203 bits (516), Expect = 2e-51
Identities = 278/1181 (23%), Positives = 518/1181 (43%), Gaps = 139/1181 (11%)
Query: 251 QALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLV 310
QA E++ KV T+ ELE E R+ ++ LL + + +L
Sbjct: 855 QAKDEELLKVKEKQTKVEGELEEME---RKHQQ--------------LLEEKNILAEQLQ 897
Query: 311 SEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQ 370
+E ++F E + ++ LA + ++E L + + E R + ++ +QA +++
Sbjct: 898 AETELFAEAE--EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDL 955
Query: 371 LRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEAL 430
++ L E++ A+Q++Q L+K A++ ++ + LE QN + + K + +++
Sbjct: 956 --EEQLDEEEGARQKLQ--LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011
Query: 431 ESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQ 490
S Q A E E + L + +R+ + ++SD E +L E+T + R L G+
Sbjct: 1012 SS-----QLAEEEEKAKNLAK-IRNKQEVMISDLEE--RLKKEEKTRQELEKAKRKLDGE 1063
Query: 491 RTPSPPR-----------RSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQ--D 537
T + + + +G + A D TL ++ R+LQ Q +
Sbjct: 1064 TTDLQDQIAELQAQIDELKLQLAKKEEELQG-ALARGDDETLHKNNALKVVRELQAQIAE 1122
Query: 538 MRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSA 597
++ +E+ + KQ D E AL+ +L+ D T + ++EV L+ A
Sbjct: 1123 LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA 1182
Query: 598 NELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARV 657
E K++ A + Q+ A L + E+L E+ +R + LE+ ++ D +
Sbjct: 1183 LE--EETKNHEAQIQDMRQRHATALEELSEQL----EQAKRFKANLEKNKQGLETDNKEL 1236
Query: 658 RRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGR 717
E++ + + E KR L ++ E+ +S R L + +++ L
Sbjct: 1237 ACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLL 1296
Query: 718 VELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAE 777
E E K + ASL+ L L + + KL+L+ + QLEEEK++LQ +Q + E
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1356
Query: 778 QEATVAREEQERLEELRLEQEVARQGLE-----GSLRVAEQAQ-------EALEQQLPT- 824
+ AR+ E+ + L L+ ++A + G++ E+A+ EAL Q+L
Sbjct: 1357 E----ARKNLEK-QVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEK 1411
Query: 825 ------LRHERSQLQEQLAQLSRQLSGREQ---ELEQARRE------AQRQVEALERAAR 869
L +++LQ++L L+ L + Q LE+ +++ ++ + A R
Sbjct: 1412 ALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEER 1471
Query: 870 EK-EALAKEHAGLAVQLVAAEREGRTLSEEATR----LRLEKEALEGSLFEVQRQLAQLE 924
++ EA A+E A+ L A E EE R LR + E L S +V + + +LE
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE 1531
Query: 925 ARREQLEAEGQALLLAKETLTGEL-----AGLRQQIIATQEKASLDKELMAQK------- 972
+ LE + + + E L EL A LR ++ KA +++L +
Sbjct: 1532 KSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKK 1591
Query: 973 --LVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLAR 1030
L++ RE +A L ++R + +++ E ++LEA+ + ++ + E + L +
Sbjct: 1592 RLLIKQVRELEAELEDERKQRALAVAS-KKKMEIDLKDLEAQ-IEAANKARDEVIKQLRK 1649
Query: 1031 LEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISL 1090
L+A+ ++ E+ + RDE + E ++ L E+E L E+L + +
Sbjct: 1650 LQAQMKDYQRELEEARASRDE-IFAQSKESEKKLKSLEAEILQLQEELASSERARR---- 1704
Query: 1091 EMERQKRDAQSRQEQDRSTVNALTSELRDLRA---QREEAAAAHAQEVRRLQEQARDLGK 1147
E+++ + S +AL E R L A Q EE + L ++ R
Sbjct: 1705 HAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL 1764
Query: 1148 QRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRE------SQEGREVQRQEA--G 1199
Q D+ E R+ + ++AR L R+ E + KL+E S+ + EA G
Sbjct: 1765 QVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIG 1824
Query: 1200 ELRRSLGEGAKEREA----LRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEART 1255
+L L + AKER A +RR+ ++L+ + E ER + A++ KEQ +E+A
Sbjct: 1825 QLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER---RHADQYKEQ----MEKANA 1877
Query: 1256 AVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGER 1315
+ +L+ L+E E A ++L+R++ N L RE++ L+ RL G
Sbjct: 1878 RMK----QLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGP 1933
Query: 1316 AEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQE 1356
S R G RQ L+G ASLE+ + + + E +
Sbjct: 1934 ISFSSSRS--GRRQLHLEG-ASLELSDDDTESKTSDVNETQ 1971
Score = 189 bits (481), Expect = 2e-47
Identities = 268/1258 (21%), Positives = 519/1258 (41%), Gaps = 181/1258 (14%)
Query: 621 ELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAK 680
++ ++ E+LQA EEL + +++ +V ELE R+ +QL ++++LA+
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQ-----------TKVEGELEEMERKHQQLLEEKNILAE 894
Query: 681 ELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSK 740
+L QAE AEA E +L A++ L++ L
Sbjct: 895 QL-----------------QAETELFAEA-----------EEMRARLAAKKQELEEILHD 926
Query: 741 LSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVA 800
L ES +++ + N++ L+ EK +Q + E++ EE+ ++L+LE+ A
Sbjct: 927 L----ESRVEEEEERNQI---LQNEKKKMQAHIQDLEEQLD---EEEGARQKLQLEKVTA 976
Query: 801 RQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQ 860
E ++ E+ LE Q E+ +++++A+ S QL+ E++ + + +Q
Sbjct: 977 ----EAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQ 1032
Query: 861 VEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEK--EALEGSLFEVQR 918
+++ ++ E R EE TR LEK L+G ++Q
Sbjct: 1033 -----------------------EVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQD 1069
Query: 919 QLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQ-----KL 973
Q+A+L+A+ ++L+ + L +E L G LA + + + +EL AQ +
Sbjct: 1070 QIAELQAQIDELKLQ---LAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQED 1126
Query: 974 VQAEREAQASLREQRAAHEEDLQRLQREKE------AAWRELEAERAQLQSQLQREQEEL 1027
++E+ ++ +Q+ E+L+ L+ E E AA +EL +R Q ++L++ EE
Sbjct: 1127 FESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE 1186
Query: 1028 LARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLAT 1087
EA+ +++ + A +E E L A+ K K+ +T E + L
Sbjct: 1187 TKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK-VLQQ 1245
Query: 1088 ISLEME--RQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDL 1145
+ E E R+K DAQ ++ ++A SE LR + E A+ E+ + +
Sbjct: 1246 VKAESEHKRKKLDAQVQE------LHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEA 1299
Query: 1146 GKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSL 1205
K+ ++A L +QL +D ++ L+ E ++KL S R+++ + + SL
Sbjct: 1300 EKKGIKFAKDAASLESQL---QDTQELLQEE---TRQKLNLSSRIRQLEEE-----KNSL 1348
Query: 1206 GEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELR 1265
E +E E R++ L V +S+ K +D + LEEA+ + K+A L
Sbjct: 1349 QEQQEEEEEARKN---LEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 1266 TGLQE-------VERSRLEARRELQEL-------RRQMKMLDSENTRLGRELAELQGRLA 1311
L+E +E+++ ++EL +L R+ L+ + + + LAE + +
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEK---S 1462
Query: 1312 LGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLE 1371
+ R +E R R++ K + + + L+ + EF + ++L +E
Sbjct: 1463 ISARYAEERDRAEAEAREKETKALSLARALEEALEAKE--------EFERQNKQLRADME 1514
Query: 1372 EARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEA 1431
+ ++ + LE A + E+ +L E Q E R+EV +A +A
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574
Query: 1432 QLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGE------GLNSPSTLECSPG 1485
Q R L + + + R+ AE E + S +E
Sbjct: 1575 QF-------ERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLK 1627
Query: 1486 ---SQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEM 1542
+Q + A L ++ ++++ +EL A+ RDE+ Q+ ++L +
Sbjct: 1628 DLEAQIEAANKARDEVIKQL--RKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSL 1685
Query: 1543 EAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQV 1602
EAE QLQ+ +A SE ARR + + E+ E+R ++
Sbjct: 1686 EAE-------ILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARI 1738
Query: 1603 ATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLE 1662
A LE L+ +S + ++ K L + + S++ +LE Q + L+
Sbjct: 1739 AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK 1798
Query: 1663 GELQRSRLGLSDR-EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESE 1721
+LQ + + +A AL+ ++ L+ Q+ + V R L ++
Sbjct: 1799 AKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV 1858
Query: 1722 GALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEAR 1781
R E + +++A + + + ++ T R+ LQ LD A +A
Sbjct: 1859 EDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLS 1918
Query: 1782 KQSSSLGEQV---------------QTLRGEVADLELQRVEAEGQLQQLREVLRQRQE 1824
++ S+L ++ + L E A LEL + E + + E + E
Sbjct: 1919 REVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQPPQSE 1976
Score = 183 bits (464), Expect = 2e-45
Identities = 270/1187 (22%), Positives = 525/1187 (44%), Gaps = 126/1187 (10%)
Query: 138 VRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQL--VQRLQGKILQYKKRCSELEQQLL 195
V+ +++ RQ +E QA L+ ++ + + +L ++R ++L+ K +E Q
Sbjct: 841 VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET 900
Query: 196 ERSGELEQQRLRDTEHSQDLESAL----IRLEEEQQRSASLAQVNAM-------LREQLD 244
E E E+ R R Q+LE L R+EEE++R+ L L EQLD
Sbjct: 901 ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLD 960
Query: 245 QAGSANQALSEDIRKVTNDWTRCRKE-----LEHREAAWRREEESFNAYFSNEHSRLLLL 299
+ A Q L + KVT + + E LE + + + +E++ + S+L
Sbjct: 961 EEEGARQKLQ--LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018
Query: 300 WRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGL---GLSTGLRLAESRAEAA 356
+ ++ ++ ++ DL + + +T + +++A G +T L+ + +A
Sbjct: 1019 EEKAKNLAKIRNKQEVMIS-DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1077
Query: 357 LEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEK 416
+++ L A+ EE+L+ + R D + + +L A++ EL + + +
Sbjct: 1078 IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1137
Query: 417 DQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERT 476
++ +DL+E+LEAL++ +T D QQ LR + +++ + ++
Sbjct: 1138 EKQKRDLSEELEALKT------ELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE 1191
Query: 477 ADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQ 536
A + R + S + + + +D+ LA L + + + +
Sbjct: 1192 AQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESE 1251
Query: 537 DMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRS 596
R + +A + L ++S+ + R L E+ +L+++ D E+A+++ +
Sbjct: 1252 HKRKKLDAQ---VQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF-- 1306
Query: 597 ANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGAR 656
+++ ++L LQ Q+ +E +++ L + +L +++ L+E+QE+ +
Sbjct: 1307 -----AKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE---- 1357
Query: 657 VRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAG 716
R+ LE+ Q+ +S LA +V + L + L+ K ++ +
Sbjct: 1358 ARKNLEK------QVLALQSQLADTKKKVDDDLGTI----ESLEEAKKKLLKDAEALSQR 1407
Query: 717 RVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQA 776
E L+ KL + LQ L L+ LD R VA EK + Q A
Sbjct: 1408 LEEKALAYDKLEKTKNRLQQELDDLTV--------DLDHQRQVAS-NLEKKQKKFDQLLA 1458
Query: 777 EQEATVAR--EEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQE 834
E+++ AR EE++R E E+E L +L A +A+E E+Q LR + L
Sbjct: 1459 EEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMS 1518
Query: 835 QLAQLSRQLSGREQELEQARREAQRQVEALERAAR--EKEALAKEHAGLAVQLVAAEREG 892
+ + + ELE+++R ++QVE + E E A E A L +++ +
Sbjct: 1519 SKDDVGKNV----HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574
Query: 893 RTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLA-KETLTGELAGL 951
+ + TR +E + +V+ A+LE R+Q +AL +A K+ + +L L
Sbjct: 1575 QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ-----RALAVASKKKMEIDLKDL 1629
Query: 952 RQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 1011
QI A KA + +KL ++ Q L E RA+ +E + +E E + LEA
Sbjct: 1630 EAQIEAA-NKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQ-SKESEKKLKSLEA 1687
Query: 1012 ERAQLQSQLQREQEELLARLEAEKEELSEEI--------AALQQERDEGLLLAESEKQQA 1063
E QLQ +L E E E++EL++EI A L ++R +A+ E++
Sbjct: 1688 EILQLQEEL-ASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE-- 1744
Query: 1064 LSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQ----SRQEQDR------------ 1107
L ++S L+++ T + T++ E+ ++ AQ +RQ+ +R
Sbjct: 1745 LEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQEL 1804
Query: 1108 ---------STVNALTSELRDLRAQREEAA---AAHAQEVRRLQEQARDLGKQRDSCLRE 1155
+T++AL +++ L Q E+ A AA + VRR +++ +++ Q + R
Sbjct: 1805 EGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRH 1864
Query: 1156 AEELRTQLRLLEDARDGLRRELLEAQRK-LRESQEGREVQRQ--EAGELRRSLG-EGAKE 1211
A++ + Q+ L+R+L EA+ + R + R++QR+ +A E L E +
Sbjct: 1865 ADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTL 1924
Query: 1212 REALRR----SNEELRSAVKKAESERISLKLANEDKEQKLALLEEAR 1254
+ LRR S RS ++ E SL+L+++D E K + + E +
Sbjct: 1925 KNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQ 1971
Score = 179 bits (455), Expect = 2e-44
Identities = 245/1058 (23%), Positives = 462/1058 (43%), Gaps = 181/1058 (17%)
Query: 527 ALHKRQLQ--VQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAH 584
A K++L+ + D+ R E ++ L+ + ++ + LEEQL D+ +GA Q
Sbjct: 914 AAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL----DEEEGARQKL 969
Query: 585 E----DAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEE----LRQEREKLQAAQEEL 636
+ A+ +++++ LL + S ++ + + E L +E EK + + +
Sbjct: 970 QLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAK-I 1028
Query: 637 RRQRDRLEEEQEDAVQDGARVRRELERSHRQLE---------------QLEGKRSVLAKE 681
R +++ + + E+ ++ + R+ELE++ R+L+ Q++ + LAK+
Sbjct: 1029 RNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKK 1088
Query: 682 LVEVREALSRA---TLQRDM-------LQAEKAEVAEALTKAEAGRVELELSMTKLRAE- 730
E++ AL+R TL ++ LQA+ AE+ E +A R + E L E
Sbjct: 1089 EEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEEL 1148
Query: 731 ---EASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGR-QRQAEQEATVAREE 786
+ L+D+L +A E + + ++ L LEEE + + Q ++ AT E
Sbjct: 1149 EALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEEL 1208
Query: 787 QERLEE---LRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQL 843
E+LE+ + E +QGLE + + L+Q H+R +L Q+ +L ++
Sbjct: 1209 SEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKV 1268
Query: 844 SGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLR 903
S ++ +VE E+A++ L E ++ L AE++G +++A L
Sbjct: 1269 SEGDR----------LRVELAEKASK----LQNELDNVSTLLEEAEKKGIKFAKDAASLE 1314
Query: 904 LEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQE--- 960
+ + + L E RQ L +R QLE E +L +E L +Q++A Q
Sbjct: 1315 SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLA 1374
Query: 961 --KASLDKEL-------MAQKLVQAEREAQASLREQRAAHEEDLQ----RLQREKEAAWR 1007
K +D +L A+K + + EA + E++A + L+ RLQ+E +
Sbjct: 1375 DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTV 1434
Query: 1008 ELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLK 1067
+L+ +R Q+ S L+++Q++ +L AE++ +S A +ERD A ++ +ALSL
Sbjct: 1435 DLDHQR-QVASNLEKKQKKF-DQLLAEEKSISARYA---EERDRAEAEAREKETKALSLA 1489
Query: 1068 ESEKTALSEK----------------LMGTRHSLATISLEMERQKRDAQSRQEQDRSTVN 1111
+ + AL K LM ++ + E+E+ KR + + E+ R+ +
Sbjct: 1490 RALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLE 1549
Query: 1112 ALTSEL----------------------RDLRA---QREEAAAAHAQEVRRLQEQARDLG 1146
L EL RDL+ Q EE ++VR L+ + D
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDER 1609
Query: 1147 KQRDSCLREAEELRTQLRLLE---DARDGLRRELLEAQRKLRESQEGREVQRQEAGELRR 1203
KQR + +++ L+ LE +A + R E+++ RKL+ + + +R
Sbjct: 1610 KQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK----------DYQR 1659
Query: 1204 SLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGE 1263
L E R+ + ++E +K E+E + L+ E+ E+ R + E
Sbjct: 1660 ELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITN 1719
Query: 1264 LRTGLQEV--ERSRLEAR-----RELQELRRQMKMLDSENTRLGRELAELQGRLALGERA 1316
+G + E+ RLEAR EL+E + M++L+ + ++ L LA A
Sbjct: 1720 SASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA----A 1775
Query: 1317 EKESRRETLGLRQRLLKGEASLEVMRQELQVA------------QRKLQEQEGEFRTRER 1364
E+ + +++ RQ+L + L+ QEL+ A + K+ + E + +
Sbjct: 1776 ERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAK 1835
Query: 1365 RLLGSLEEARGTEKQ----------QLDHARGLELKLEAARAEAAELGLRLSAAEGRAQG 1414
+ + R TEK+ + HA + ++E A A +L +L AE A
Sbjct: 1836 ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEA-- 1893
Query: 1415 LEAELARVEVQRRAAEA---------QLGGLRSALRRG 1443
A +R ++QR +A ++ L++ LRRG
Sbjct: 1894 TRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRG 1931
Score = 178 bits (451), Expect = 5e-44
Identities = 256/1213 (21%), Positives = 522/1213 (43%), Gaps = 148/1213 (12%)
Query: 808 LRVAEQAQE--ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALE 865
L+V Q +E A +++L ++ ++++++ +L ++ R+ +E + Q + E
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 866 RAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEA 925
A + LA + L L E E L+ EK+ ++ + +++ QL + E
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 926 RREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASL---DKELMAQKLVQAEREAQA 982
R++L+ E K T ++ + ++I+ +++ S +K+LM ++ AE +Q
Sbjct: 965 ARQKLQLE-------KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI--AECSSQL 1015
Query: 983 SLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEI 1042
+ E++A ++L +++ ++E +LE ER + + + ++E E+ +L+ E +L ++I
Sbjct: 1016 AEEEEKA---KNLAKIRNKQEVMISDLE-ERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071
Query: 1043 AALQQERDE---GLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATIS-----LEMER 1094
A LQ + DE L E E Q AL+ + E + L R A I+ E E+
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131
Query: 1095 QKRDAQSRQEQDRSTVNALTSELRDLRAQREEA--AAAHAQEVRRLQEQARDLGKQRDSC 1152
R+ +Q++D L+ EL L+ + E+ A QE+R +EQ
Sbjct: 1132 ASRNKAEKQKRD------LSEELEALKTELEDTLDTTAAQQELRTKREQ----------- 1174
Query: 1153 LREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKER 1212
E EL+ + LE+ ++ + +++ + E Q ++A + +L K +
Sbjct: 1175 --EVAELK---KALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL---EKNK 1226
Query: 1213 EALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVE 1272
+ L N+EL VK + +K +E K +KL + A E LR L E +
Sbjct: 1227 QGLETDNKELACEVKVLQQ----VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAE-K 1281
Query: 1273 RSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLL 1332
S+L+ EL + ++ + + + ++ A L+ +L + +E R+ L L R+
Sbjct: 1282 ASKLQ--NELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIR 1339
Query: 1333 KGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLE 1392
+ LE + LQ + QE+E E R + + +L+ K+++D G LE
Sbjct: 1340 Q----LEEEKNSLQ----EQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLE 1391
Query: 1393 AARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSP 1452
A+ + L AE +Q LE ++ A +L ++ L++ L
Sbjct: 1392 EAKKKL------LKDAEALSQRLE--------EKALAYDKLEKTKNRLQQELDDLTVDLD 1437
Query: 1453 APRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALR 1512
R V + E + + E S ++ + + + +A+ A
Sbjct: 1438 HQRQVASN------LEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLA-- 1489
Query: 1513 EFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDG 1572
+ L A ++E Q L + ++ + +D +L+K+ E+ +
Sbjct: 1490 ---RALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRT 1546
Query: 1573 RLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEK----ISKMKA 1628
+L ++ EL E++ R E +A A ER LQ + + ++EK I +++
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQA---MKAQFERDLQTRDEQ---NEEKKRLLIKQVRE 1600
Query: 1629 NETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDS 1688
E +LE D+R+ + + AS+ K+E+ + LE +++ + + Q + LQ ++
Sbjct: 1601 LEAELE-DERKQRALAVASKK---KMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKD 1656
Query: 1689 LQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDK 1748
QR++ E A RD++ ++ +S L S +
Sbjct: 1657 YQREL-------------------------EEARASRDEIFAQSK---ESEKKLKSLEAE 1688
Query: 1749 NLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEA 1808
L LQ+ L + E R+ ++ D ++ + S+L ++ + L +A LE + E
Sbjct: 1689 ILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEE 1748
Query: 1809 EGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSA 1868
+ ++ L + R + + LN +L ER Q+ A QLE + +E++
Sbjct: 1749 QSNMELLNDRFR-KTTLQVDTLNA--ELAAERSAAQKS----DNARQQLERQNKELKAKL 1801
Query: 1869 LRLE-KDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQL 1927
LE + + T+ +E + + E + + E+ ++ + E +L E Q++
Sbjct: 1802 QELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDE 1861
Query: 1928 EAQVVVLEQSHSPAQLEVDAQQQQL-ELQQEVERLRSAQAQTERTLEARERAHRQRVRGL 1986
++ A + ++QL E ++E R +++ + +R L+ A+ GL
Sbjct: 1862 RRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEAN----EGL 1917
Query: 1987 EEQVSTLKGQLQQ 1999
+VSTLK +L++
Sbjct: 1918 SREVSTLKNRLRR 1930
Score = 172 bits (436), Expect = 3e-42
Identities = 262/1204 (21%), Positives = 513/1204 (42%), Gaps = 168/1204 (13%)
Query: 80 QEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVR 139
+EE Q +EL +V++ + E +E+ K+ + E E+ + E + ET+ L
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLE--EKNILAEQLQAETE----LFA 904
Query: 140 QSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSG 199
++ E+R +L ++ L + + + + Q LQ + + + +LE+QL E G
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 200 ELEQQRLRDTEHSQDLESALIRLEEE----QQRSASLAQVNAMLREQLDQAGS---ANQA 252
++ +L E+ + ++EEE + +++ + ++ +++ + S +
Sbjct: 965 ARQKLQLEKV----TAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEE 1020
Query: 253 LSEDIRKVTNDWTRCRKELEHR---EAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRL 309
++++ K+ N +LE R E R+E E E + L Q+ +
Sbjct: 1021 KAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTD---LQDQIAELQAQ 1077
Query: 310 VSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAA--LEKQALLQAQL 367
+ E+K+ + +L G LAR L L AE E + + +
Sbjct: 1078 IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1137
Query: 368 EEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKL 427
E+Q RD + E + + +++ LD + L KR E++ E + ++ T+
Sbjct: 1138 EKQKRD-LSEELEALKTELEDTLD-----TTAAQQELRTKR-EQEVAELKKALEEETKNH 1190
Query: 428 EA-LESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADA------- 479
EA ++ +R + ALE E E L+Q R +A L ++ G++ E +
Sbjct: 1191 EAQIQDMRQRHATALE-ELSEQLEQAKR--FKANLEKNKQGLETDNKELACEVKVLQQVK 1247
Query: 480 --SNGSLRGLSGQRTPSPPRRSSPGRGR-SPRRGPSPACSDSSTLALIHSALHKRQLQ-- 534
S + L Q + S R R S ++ ++ + K+ ++
Sbjct: 1248 AESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFA 1307
Query: 535 --VQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQ 592
+ + + +Q+LL +Q + S R LEE+ L+++ + +A ++ +++V
Sbjct: 1308 KDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL 1367
Query: 593 RLRSANELLSREKS-----NLAHSLQVAQQQ----AEELRQEREKLQAAQEELRRQRDRL 643
L+S +L +K SL+ A+++ AE L Q E+ A ++L + ++RL
Sbjct: 1368 ALQS--QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRL 1425
Query: 644 EEEQEDAVQD---GARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ 700
++E +D D +V LE+ ++ +QL + ++ E R+ RA + +
Sbjct: 1426 QQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERD---RAEAEAREKE 1482
Query: 701 AEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVA 760
+ +A AL +A + E E +LRA+ E L K D+ + V
Sbjct: 1483 TKALSLARALEEALEAKEEFERQNKQLRAD--------------MEDLMSSKDDVGKNVH 1528
Query: 761 QLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQ 820
+LE+ K AL ++++EE+R + E LE L+ E A+ LE
Sbjct: 1529 ELEKSKRAL-----------------EQQVEEMRTQLE----ELEDELQATEDAKLRLEV 1567
Query: 821 QLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALE---RAAREKEALA-- 875
+ ++ AQ R L R+++ E+ +R +QV LE R++ ALA
Sbjct: 1568 NMQAMK----------AQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVA 1617
Query: 876 -KEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEG 934
K+ + ++ + A+ E + + +L K L+ + + QR+L + A R+++ A+
Sbjct: 1618 SKKKMEIDLKDLEAQIEAANKARDEVIKQLRK--LQAQMKDYQRELEEARASRDEIFAQS 1675
Query: 935 QALLLAKETLTGELAGLRQQIIATQ---EKASLDKELMAQKLVQAEREAQASLREQR--- 988
+ ++L E+ L++++ +++ A +++ +A ++ + A L E+R
Sbjct: 1676 KESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLE 1735
Query: 989 ---AAHEEDLQRLQREKE--------------AAWRELEAERAQLQ------SQLQREQE 1025
A EE+L+ Q E EL AER+ Q QL+R+ +
Sbjct: 1736 ARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNK 1795
Query: 1026 ELLARLE----AEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGT 1081
EL A+L+ A K + I+AL+ + + + E+Q L + E+ A ++ + T
Sbjct: 1796 ELKAKLQELEGAVKSKFKATISALEAK------IGQLEEQ--LEQEAKERAAANKLVRRT 1847
Query: 1082 RHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQ 1141
L I +++E ++R A +EQ + R L EEA A+A R+LQ +
Sbjct: 1848 EKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR-RKLQRE 1906
Query: 1142 ARDLGKQRDSCLREAEELRTQLR-----LLEDARDGLRRELLEAQRKLRESQEGREVQRQ 1196
D + + RE L+ +LR +R G RR+L L S + E +
Sbjct: 1907 LDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSG-RRQLHLEGASLELSDDDTESKTS 1965
Query: 1197 EAGE 1200
+ E
Sbjct: 1966 DVNE 1969
Score = 141 bits (355), Expect = 7e-33
Identities = 202/912 (22%), Positives = 379/912 (41%), Gaps = 122/912 (13%)
Query: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKERE 1213
R+ EEL+ A+D ++ E Q K+ E E + Q+ E + L E +
Sbjct: 849 RQEEELQ--------AKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET 900
Query: 1214 ALRRSNEELRS--AVKKAESERI--SLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQ 1269
L EE+R+ A KK E E I L+ E++E++ +L+ + + +L L
Sbjct: 901 ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLD 960
Query: 1270 EVERSR-------LEARRELQELRRQMKMLDSENTRLGRELAELQGRLA--LGERAEKES 1320
E E +R + A +++++ ++ +L+ +N++ +E ++ R+A + AE+E
Sbjct: 961 EEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEE 1020
Query: 1321 RRETLG------------LRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLG 1368
+ + L L +RL K E + RQEL+ A+RKL + + + + L
Sbjct: 1021 KAKNLAKIRNKQEVMISDLEERLKKEEKT----RQELEKAKRKLDGETTDLQDQIAELQA 1076
Query: 1369 SLEE-----ARGTEKQQLDHARGLELKLEAARA--EAAELGLRLSAAEGRAQGLEAELAR 1421
++E A+ E+ Q ARG + L A EL +++ + + +A +
Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1136
Query: 1422 VEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLE 1481
E Q+R +L L++ L L A + L + E
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQ---------------------QELRTKREQE 1175
Query: 1482 CSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAE 1541
+ + A + AL E ++L A+R + L L E
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235
Query: 1542 MEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQ 1601
+ E + LQ+ AESE R+ +D ++ + A+ V +R R ++
Sbjct: 1236 LACE-------VKVLQQVKAESEHKRKKLDAQVQELHAK-------VSEGDRLRVELAEK 1281
Query: 1602 VATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSL 1661
+ L+ L + L +++K K + LE + +E+L + + L + R L
Sbjct: 1282 ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQL 1341
Query: 1662 EGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESE 1721
E E + + E + L+ +V +LQ Q+AD++ K T+E L A K+ +
Sbjct: 1342 EEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDA 1401
Query: 1722 GALRDKVRGLTEALAQSSASLNSTRDK-NLHLQKALTACEHDRQV---LQERLDAARQAL 1777
AL ++ E A + L T+++ L +H RQV L+++ Q L
Sbjct: 1402 EALSQRL----EEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLL 1457
Query: 1778 SEARKQSSSLGEQVQTLRGEVADLELQ--------------RVEAEGQLQQLREVLRQRQ 1823
+E + S+ E+ E + E + + E E Q +QLR +
Sbjct: 1458 AEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLM 1517
Query: 1824 EGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALR---- 1879
+ V +L+ +R L++++ ++ L +LE E + E + LRLE + A++
Sbjct: 1518 SSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE 1577
Query: 1880 ---RTLDKVEREKLRSHEDTVR---LSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVV 1933
+T D+ EK R VR E R R L A + E ++ LEAQ+
Sbjct: 1578 RDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEI--DLKDLEAQIEA 1635
Query: 1934 LEQSHSPAQLEVDAQQQQL-ELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVST 1992
++ ++ Q Q+ + Q+E+E R+++ + + A+ + ++++ LE ++
Sbjct: 1636 ANKARDEVIKQLRKLQAQMKDYQRELEEARASRDE----IFAQSKESEKKLKSLEAEIL- 1690
Query: 1993 LKGQLQQELRRS 2004
QLQ+EL S
Sbjct: 1691 ---QLQEELASS 1699
Score = 107 bits (266), Expect = 2e-22
Identities = 169/797 (21%), Positives = 326/797 (40%), Gaps = 135/797 (16%)
Query: 77 LSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRG 136
+ L E+ LQ EL V LL E ++ IK+ + LE L+ + EL +E R
Sbjct: 1276 VELAEKASKLQNELDNVSTLLE----EAEKKGIKFAKDAASLESQLQ-DTQELLQEETRQ 1330
Query: 137 LVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLE 196
+ S +R QL+EE+ S + + + +E ++ + V LQ ++ KK+ + + +E
Sbjct: 1331 KLNLSSRIR-QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD-DLGTIE 1388
Query: 197 RSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSED 256
E +++ L+D E + RLEE+ L + L+++LD L+ D
Sbjct: 1389 SLEEAKKKLLKDAE------ALSQRLEEKALAYDKLEKTKNRLQQELDD-------LTVD 1435
Query: 257 I---RKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEV 313
+ R+V ++ + +K+ + A EE+S +A ++ E R
Sbjct: 1436 LDHQRQVASNLEKKQKKFDQLLA----EEKSISARYAEERDR------------------ 1473
Query: 314 KMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRD 373
AE+ A K L LEE L
Sbjct: 1474 -----------------------------------AEAEAREKETKALSLARALEEALEA 1498
Query: 374 KVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALE-S 432
K ++ +Q Q D DL + ++G V LEK +Q +++ +LE LE
Sbjct: 1499 K----EEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE 1554
Query: 433 LRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRT 492
L+ E A L E QA+ + E +Q T D N + L ++
Sbjct: 1555 LQATEDAKLRLEVN----------MQAMKAQFERDLQ------TRDEQNEEKKRLLIKQV 1598
Query: 493 PSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTL 552
R + + AL ++ K ++ ++D+ + EA+ +
Sbjct: 1599 ---------------RELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEV 1643
Query: 553 RKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQR-----EVQRLRSANELLSREKSN 607
KQL +++ + + +L+ R D +++++ E + L+ EL S E++
Sbjct: 1644 IKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERAR 1703
Query: 608 LAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQ 667
H+ Q + A+E+ A +E RR R+ + +E+ ++ + + +R +
Sbjct: 1704 -RHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKT 1762
Query: 668 LEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE-AGRVELELSMTK 726
Q++ L EL R A ++ R L+ + E+ L + E A + + + +++
Sbjct: 1763 TLQVD----TLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISA 1818
Query: 727 LRAE----EASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV 782
L A+ E L+ + +A N+ + + + L + Q+E+E+ + Q E+
Sbjct: 1819 LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANAR 1878
Query: 783 AREEQERLEELRLE---QEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQL 839
++ + +LEE E +R+ L+ L A +A E L +++ TL++ R + ++
Sbjct: 1879 MKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKN-RLRRGGPISFS 1937
Query: 840 SRQLSGREQELEQARRE 856
S + R+ LE A E
Sbjct: 1938 SSRSGRRQLHLEGASLE 1954
Score = 70.1 bits (170), Expect = 2e-11
Identities = 87/377 (23%), Positives = 161/377 (42%), Gaps = 70/377 (18%)
Query: 1639 RLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV-ADSE 1697
R +E L A + +K++ ++ +EGEL+ + E + Q L + + L Q+ A++E
Sbjct: 849 RQEEELQAKDEELLKVKEKQTKVEGELE-------EMERKHQQLLEEKNILAEQLQAETE 901
Query: 1698 VKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALT 1757
+ A+ EE L K + L E L + + ++N LQ
Sbjct: 902 L---------------FAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKK 946
Query: 1758 ACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLRE 1817
+ Q L+E+LD A + L+L++V AE +++++ E
Sbjct: 947 KMQAHIQDLEEQLDEEEGARQK---------------------LQLEKVTAEAKIKKMEE 985
Query: 1818 VLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVA 1877
+ ++ + K E++L+++R +A+ ++ E E A L K R
Sbjct: 986 EILLLEDQNS-------KFIKEKKLMEDR-------IAECSSQLAEEEEKAKNLAKIRNK 1031
Query: 1878 LRRTLDKVEREKLRSHEDT-VRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQ 1936
+ +E E+L+ E T L K +LD T + ++AE Q QI +L+ Q+ E+
Sbjct: 1032 QEVMISDLE-ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEE 1090
Query: 1937 SHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLE-------ARERAHRQRVRGLEEQ 1989
A D + L ++ +R QAQ E +R +A +Q+ R L E+
Sbjct: 1091 ELQGALARGD--DETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK-RDLSEE 1147
Query: 1990 VSTLKGQLQQELRRSSA 2006
+ LK +L+ L ++A
Sbjct: 1148 LEALKTELEDTLDTTAA 1164
Score = 66.6 bits (161), Expect = 2e-10
Identities = 133/587 (22%), Positives = 234/587 (39%), Gaps = 125/587 (21%)
Query: 38 LAQDAQITSLPALIREIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLL 97
LA++ I++ A R+ + E+ L A + L +EE + ++L
Sbjct: 1457 LAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQL------- 1509
Query: 98 AQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQ----EEQA 153
RA+ ++L + V + + ELE + R L +Q E+R QL+ E QA
Sbjct: 1510 ---RADMEDLMSSKDDVGKNVH--------ELE-KSKRALEQQVEEMRTQLEELEDELQA 1557
Query: 154 SYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQ 213
+ KL+ Q +AQ + LQ + Q +++ L +Q+ E ELE
Sbjct: 1558 TEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELE----------- 1606
Query: 214 DLESALIRLEEEQQRSASLAQVNAM------LREQLDQAGSANQALSEDIRKVTNDWTRC 267
+E +QR+ ++A M L Q++ A A + + +RK+
Sbjct: 1607 ---------DERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDY 1657
Query: 268 RKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGE 327
++ELE A+ +E F +E ++L S E ++LQL E
Sbjct: 1658 QRELEEARAS---RDEIFAQSKESE--------------KKLKS-----LEAEILQLQEE 1695
Query: 328 LARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQ 387
LA + RA + A LA+ +A K ALL + + R L E++L ++Q
Sbjct: 1696 LASSERARRHAEQERD---ELADEITNSASGKSALLDEKRRLEARIAQL-EEELEEEQ-- 1749
Query: 388 SDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDL-TEKLEALESLRLQEQAALETEDG 446
+ + L R K L+ D +N +L E+ A +S ++Q LE ++
Sbjct: 1750 ------------SNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQ--LERQNK 1795
Query: 447 EGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRS 506
E L+ L++L AV S ++ T A + L Q R++ +
Sbjct: 1796 E-LKAKLQELEGAVKSKFKA---------TISALEAKIGQLEEQLEQEAKERAAANK--- 1842
Query: 507 PRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRAL 566
+ L + +QV+D R + ++Q+ + + + L
Sbjct: 1843 -------------LVRRTEKKLKEIFMQVEDERRHAD-------QYKEQMEKANARMKQL 1882
Query: 567 EEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQ 613
+ QL+ ++ A + QRE+ ANE LSRE S L + L+
Sbjct: 1883 KRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLR 1929
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 198 bits (504), Expect = 4e-50
Identities = 446/2081 (21%), Positives = 823/2081 (39%), Gaps = 308/2081 (14%)
Query: 96 LLAQSRAERDELAIKYNAVSERL---------------EQALRLEPGELETQEPRGLVRQ 140
LL Q +A+ EL K N + RL E L+LE ++E E ++ +
Sbjct: 279 LLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNK 338
Query: 141 SVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGE 200
R +L A Y + Y +Q+ +L + L + + LEQ++ E+ E
Sbjct: 339 C---RDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKE 395
Query: 201 LEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKV 260
+++ R Q L+ I Q+ A L ++L QA + + L ++ K+
Sbjct: 396 FQEELSRQQRSFQTLDQECI-------------QMKARLTQELQQAKNMHNVLQAELDKL 442
Query: 261 TNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTE-- 318
T+ + LE + R E++F A E+ L R + ++ + +K +E
Sbjct: 443 TSVKQQLENNLEEFKQKLCRAEQAFQASQIKENE----LRRSMEEMKKENNLLKSHSEQK 498
Query: 319 -RDLLQLGGELARTSRAVQEA----------GLGLSTGLR-----LAESRAEAALEKQAL 362
R++ L EL + + ++ T LR + + LEK L
Sbjct: 499 AREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKL 558
Query: 363 LQAQLEEQLRD---KVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQV 419
A LE+Q RD +L++++ +Q+ L K + ++ L +K+ E + L++++
Sbjct: 559 AVADLEKQ-RDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKT 617
Query: 420 --------NKDLTEKLEA----LESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSES- 466
N+ L ++E+ L+S + L+T+ + + R + + D E+
Sbjct: 618 LFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNER--VRTLEMDRENL 675
Query: 467 GVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLA-LIH 525
V++ D+ + + + + ++ + + ++ C +S L +
Sbjct: 676 SVEIRNLHNVLDSKSVEVE--TQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVE 733
Query: 526 SALHKRQLQ----------VQDMRGRYEASQDLLGTLRKQLSDSESERR---------AL 566
HK QL QD+ YE+ +DLL + L +E +R A+
Sbjct: 734 DLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM 793
Query: 567 EEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQER 626
+ + + + E + + +L +L SL+ +Q +L+++
Sbjct: 794 HHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQC 853
Query: 627 EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVR 686
E+L + E+ + E+ + V + + +R + E ++V+A+ L +
Sbjct: 854 EELVQIKGEIEENLMKAEQMHQSFVAETS------QRISKLQEDTSAHQNVVAETLSALE 907
Query: 687 EALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDS-LSKLSALN 745
L D ++ E+AE+ E K +E L +L +E SL+ +S + +LN
Sbjct: 908 NKEKELQLLNDKVETEQAEIQEL--KKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN 965
Query: 746 ----ESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVAR 801
E L Q+ L + A L +EK L +++E A E ++ + EL + + +
Sbjct: 966 KREIEELTQENGTLKEINASLNQEKMNLI---QKSESFANYIDEREKSISELSDQYKQEK 1022
Query: 802 QGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQV 861
L A E L Q+ + + S+L+ L + + R+ ELEQ
Sbjct: 1023 LILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQL-------- 1074
Query: 862 EALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLA 921
KEA AKEH +L AE + L E L ++AL + + Q +
Sbjct: 1075 ---------KEAFAKEHQEFLTKLAFAEERNQNLMLE---LETVQQALRSEMTDNQNN-S 1121
Query: 922 QLEA---RREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAER 978
+ EA ++E + + + + KE +L +Q++ + + L ++ + + +
Sbjct: 1122 KSEAGGLKQEIMTLKEEQNKMQKEV--NDLLQENEQLMKVMKTKHECQNLESEPIRNSVK 1179
Query: 979 EAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEEL 1038
E ++ + + DL+ KE + A+ QL++ L R +E L E EKE L
Sbjct: 1180 ERESERNQCNFKPQMDLE----VKEISLDSYNAQLVQLEAML-RNKELKLQESEKEKECL 1234
Query: 1039 SEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLAT---------IS 1089
E+ ++ + + L + + Q+ LK+ E A EK + H L+T S
Sbjct: 1235 QHELQTIRGDLETSNL-QDMQSQEISGLKDCEIDA-EEKYISGPHELSTSQNDNAHLQCS 1292
Query: 1090 LEMERQK-RDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQ 1148
L+ K + + E ++ L +EL D R++ A A+EV +L + + L
Sbjct: 1293 LQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILND- 1351
Query: 1149 RDSCLREAEELRTQLRLLEDARDGLRRELLEAQRK-----LRESQE-------GREVQRQ 1196
DS L E L+ED G E Q L ES +EVQ
Sbjct: 1352 -DSGLLHGE-------LVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMH 1403
Query: 1197 EAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTA 1256
A EL+ E + L + ++ S + + ++ SLK N L L R
Sbjct: 1404 FA-ELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAEN------LVLSTNLRNF 1456
Query: 1257 VGKEAGELRTGLQE-----------VERSRLEAR------RELQELRRQMKMLDSENTRL 1299
G E++ GL+E + S L + R L E M +L + +
Sbjct: 1457 QGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAV 1516
Query: 1300 GRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASL-EVMRQELQVAQRKLQEQEGE 1358
+ + E +R+ET + ++ SL EV RQ L+ + K++ Q G
Sbjct: 1517 SANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQ-GI 1575
Query: 1359 FRTRERRLLGSLEEARGTEKQQLDHARGLELK-----LEAARAEAAELGLRLSAAEGRAQ 1413
+ +E + LE+ +E+Q+LD R L + + E+ +L+A + + +
Sbjct: 1576 MKNKE---IQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTE 1632
Query: 1414 GLEAELARVEVQRRAAEAQLGGLRSALRRGLGL-------GR---------APSPAPRPV 1457
L EL A QL GL + R LG+ GR S
Sbjct: 1633 QLSLEL-------EVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERT 1685
Query: 1458 PGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPE-----AVRGALR 1512
P + + + LN G+ P+ G + SPD + E +G+
Sbjct: 1686 PKHDVHQICDKDAQQDLNLDIEKITETGAVKPT-GECSGEQSPDTNYEPPGEDKTQGS-S 1743
Query: 1513 EFLQELR----SAQRERDELRTQTSALNRQLAEMEAERDS------ATSRARQLQKAVAE 1562
E + EL +A D L Q N QL E ++ R R+++ + E
Sbjct: 1744 ECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNE 1803
Query: 1563 SEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEK 1622
+E +D +L + +L + E+ E+ + + L L+ + + ++
Sbjct: 1804 MKE----LDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQR 1859
Query: 1623 ISKMKANETKLE--GDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQ 1680
+ + + LE DK +++ D + + +E EL R R + E +A
Sbjct: 1860 VETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEAL 1919
Query: 1681 ALQDRVDSLQRQ----VADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALA 1736
L+ ++ +Q + D+E K + E L+ ++ + G L D + T AL
Sbjct: 1920 YLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL-DTMSKKTTALD 1978
Query: 1737 QSSASLNSTRDKNLHLQKALTACEHDRQVLQ-------ERLDAARQALSEARKQSSSLGE 1789
Q S + ++K L+ + C H QV + E L +SE K + L E
Sbjct: 1979 QLSEKM---KEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQE 2035
Query: 1790 QVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGS 1849
++Q+L + L L + E E Q+ QL + E+ LL + S
Sbjct: 2036 KLQSLEKDSQALSLTKCELENQIAQLNK---------------------EKELLVKESES 2074
Query: 1850 LQRALAQLEAEKREVERS--ALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLD 1907
LQ L++ + EK V ++ A +EK ALR + + E +LR + +R+ E
Sbjct: 2075 LQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADE-K 2133
Query: 1908 RTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL------QQEVERL 1961
+ L AE +L E +R+ L+ +V LE+ +L++ + Q+L + + EVE L
Sbjct: 2134 KQLHIAE-KLKERERENDSLKDKVENLER-----ELQMSEENQELVILDAENSKAEVETL 2187
Query: 1962 RSAQAQTERTLEARER---AHRQRVRGLEEQVSTLKGQLQQ 1999
++ + R+L+ E R L +Q+ +GQL +
Sbjct: 2188 KTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSE 2228
Score = 166 bits (421), Expect = 2e-40
Identities = 239/1106 (21%), Positives = 443/1106 (40%), Gaps = 131/1106 (11%)
Query: 375 VLREKDLAQQQMQSDLDKADLSARVTELGLAVK-----RLEKQNLEKDQVNKDLTEKLEA 429
V+ ++D + + +++ + D + E+ L K LEK E + N DL+EKLE
Sbjct: 1789 VIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEY 1848
Query: 430 LESLRLQEQAALETEDG--EGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGL 487
+ +ET +G L+ ++ + D+ + V S ER D N L
Sbjct: 1849 FSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENE----L 1904
Query: 488 SGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQD 547
S R S S + + L Q + + E Q
Sbjct: 1905 SRIR--------------------SEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQK 1944
Query: 548 LLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSN 607
++ L ++LS SER L +L + KT Q E + + Q L S +S
Sbjct: 1945 VIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELES-------HQSE 1997
Query: 608 LAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQ 667
H +QVA+ + +E + + L + EL + + L+E+ + +D + Q
Sbjct: 1998 CLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQ 2057
Query: 668 LEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKL 727
+ QL ++ +L KE ++ LS + EK V++AL A + E L ++
Sbjct: 2058 IAQLNKEKELLVKESESLQARLSES-------DYEKLNVSKALEAALVEKGEFALRLSST 2110
Query: 728 RAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQ 787
+ E L+ + KL E+ + +L + + + E E +L+ + E+E ++ E Q
Sbjct: 2111 QEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQ 2170
Query: 788 ERL----EELRLEQEVARQGLE---GSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLS 840
E + E + E E + +E SL+V E L + L + + Q QL++L
Sbjct: 2171 ELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELD 2230
Query: 841 RQLSG-------REQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGR 893
+ LS +EQ Q + E++ VE L+ +E G + A E+
Sbjct: 2231 KLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLD 2290
Query: 894 TLSEEATRLRLEKEALEGSL-FEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLR 952
EE +LR E L L + ++QL L+ +E E L E L EL R
Sbjct: 2291 PPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKES-EHHADLLKGRVENLERELEIAR 2349
Query: 953 QQIIATQEKASLDKE----------LMAQKLVQAEREAQASLREQRAAHEEDLQRLQREK 1002
QE A+L+ E + + Q+ R + + R+ E LQ+E+
Sbjct: 2350 ----TNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQ 2405
Query: 1003 E---------AAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGL 1053
E +++ + E+ Q + Q++ + + L+ + +EL+E +AAL ++ E
Sbjct: 2406 ERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQ-EAC 2464
Query: 1054 LLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNAL 1113
E + E EK L + L +++ + +S+VN L
Sbjct: 2465 KAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVL------------------QSSVNGL 2506
Query: 1114 TSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGL 1173
E+ D + + E+ +E+ RL+ Q +D ++ + + ++ + +L ++ L
Sbjct: 2507 IQEVEDGKQKLEK----KDEEISRLKNQIQD----QEQLVSKLSQVEGEHQLWKEQNLEL 2558
Query: 1174 RRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESER 1233
R +E ++K++ Q + L+ S E E + V K ++
Sbjct: 2559 RNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE 2618
Query: 1234 ISLKLANEDKEQKLA-LLEEARTAVGKEAGELRTGLQEVERSR---LEARRELQELRRQM 1289
L+ + QK A L EE + AGEL+ L+E++ S+ E E EL++ +
Sbjct: 2619 TELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSL 2678
Query: 1290 KMLDSENT----RLGRELAELQGRLALGER--------AEKESRRETLGLRQRLLKGEAS 1337
+ + ++ E+AE Q RL E+ K+ E R++L E
Sbjct: 2679 DCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEEC 2738
Query: 1338 LEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAE 1397
L + E+ + + +E + + LEE + T+ L + L+ + E A+ +
Sbjct: 2739 LSSQKLEIDLLKSSKEELNNSLKATTQ----ILEELKKTKMDNLKYVNQLKKENERAQGK 2794
Query: 1398 AAELGLRLSAAEGRAQGLEAELARVE 1423
L E + L+ EL++++
Sbjct: 2795 MKLLIKSCKQLEEEKEILQKELSQLQ 2820
Score = 160 bits (406), Expect = 9e-39
Identities = 397/1947 (20%), Positives = 775/1947 (39%), Gaps = 225/1947 (11%)
Query: 79 LQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLV 138
L E L + + +E L E E K A +E Q L LE LET + + L
Sbjct: 1057 LNECTSLCENRKNELEQLKEAFAKEHQEFLTKL-AFAEERNQNLMLE---LETVQ-QALR 1111
Query: 139 RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQG------KILQYKKRCSELEQ 192
+ + + + E ++++ +E Q + + V L K+++ K C LE
Sbjct: 1112 SEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLES 1171
Query: 193 QLLERS-GELEQQRLR-DTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQ---LDQAG 247
+ + S E E +R + + + DLE I L+ +A L Q+ AMLR + L ++
Sbjct: 1172 EPIRNSVKERESERNQCNFKPQMDLEVKEISLDSY---NAQLVQLEAMLRNKELKLQESE 1228
Query: 248 SANQALSEDIRKVTNDW-TRCRKELEHREAAWRR--EEESFNAYFS---------NEHSR 295
+ L +++ + D T ++++ +E + + E ++ Y S N+++
Sbjct: 1229 KEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAH 1288
Query: 296 LLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEA 355
L + + + ++ + + +L EL + A ++ + + +
Sbjct: 1289 LQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKI 1348
Query: 356 ALEKQALLQAQLEEQLRDKVLREKDLAQQQMQ-SDLDKADLSARVT----ELGLAVKRLE 410
+ LL +L E + E+ Q + + LD+++ +T E+ + L+
Sbjct: 1349 LNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQ 1408
Query: 411 KQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGL--QQTLRDLAQAVLSDSESGV 468
++ L +K L ++ + S + Q +++ E L LR+ ++ + + G+
Sbjct: 1409 EKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGL 1468
Query: 469 QLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSAL 528
+ G + LS P SS G S R D S L+ + A+
Sbjct: 1469 E-----------EGLVPSLSSSCVPDSSSLSSLGDS-SFYRALLEQTGDMSLLSNLEGAV 1516
Query: 529 HKRQLQVQDMRGRYEASQDLL-----GTLRKQLSDSESERRALEEQLQRLRDKTD--GAM 581
Q V ++ ++L K + + ES + L++L +K + G M
Sbjct: 1517 SANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIM 1576
Query: 582 QAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRD 641
+ +E+Q L +LLS E+ L + +Q E Q ++KL + E+
Sbjct: 1577 K-----NKEIQELE---QLLSSERQELDC---LRKQYLSENEQWQQKLTSVTLEME---S 1622
Query: 642 RLEEEQEDAVQDGARVRRELERSHRQLEQLE-GKRSVLAKELVEVREALSRATLQRDMLQ 700
+L E++ Q + ELE + QL+ L+ RS+L ++ +A+ D+ +
Sbjct: 1623 KLAAEKKQTEQ----LSLELEVARLQLQGLDLSSRSLLG---IDTEDAIQGRNESCDISK 1675
Query: 701 AEKAEVAEALTKAEAGRV-------ELELSMTKLRAE----------------------- 730
+E E K + ++ +L L + K+
Sbjct: 1676 EHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPG 1735
Query: 731 EASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEAT----VAREE 786
E Q S +S L+ S + ++ L Q E+ LQ R ++ E V +
Sbjct: 1736 EDKTQGSSECISELSFSGPNALVPMDFLGNQ--EDIHNLQLRVKETSNENLRLLHVIEDR 1793
Query: 787 QERLEELRLEQEVARQGL---EGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQL 843
++E L E + L E L +A LE+ + L+ E S L E+L S
Sbjct: 1794 DRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDH 1853
Query: 844 SGREQELEQARREAQRQVEALERAAREK--EALAKEHAGLAVQLVAAEREGRTLSEEATR 901
Q +E + ++++RE + +AK + + + E E + E
Sbjct: 1854 QELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKAS 1913
Query: 902 LRLEKEALEGSLFEVQRQLAQLEARREQ-------LEAEGQALLLAKETLTGELAGLRQQ 954
+ E LE L VQ + LE E LE E + + L GEL + ++
Sbjct: 1914 IEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKK 1973
Query: 955 IIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERA 1014
A + + KE Q+L + E ++ A +E + LQ EL ++
Sbjct: 1974 TTALDQLSEKMKE-KTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDV-SELLKDKT 2031
Query: 1015 QLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQA-LSLKESEKTA 1073
LQ +LQ +++ A L K EL +IA L +E++ LL+ ESE QA LS + EK
Sbjct: 2032 HLQEKLQSLEKDSQA-LSLTKCELENQIAQLNKEKE--LLVKESESLQARLSESDYEKLN 2088
Query: 1074 LSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQ 1133
+S+ L +L + S QE+ V+ L + LR + E A +
Sbjct: 2089 VSKALEAALVEKGEFALRLS-------STQEE----VHQLRRGIEKLRVRIE----ADEK 2133
Query: 1134 EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREV 1193
+ + E+ ++ ++ DS + E L +L++ E+ ++ + +L+A+ E E
Sbjct: 2134 KQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELV---ILDAENSKAEV----ET 2186
Query: 1194 QRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISL-------KLANEDKEQ- 1245
+ + E+ RSL + LR E L +++ + + L K E+KEQ
Sbjct: 2187 LKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQA 2246
Query: 1246 KLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAE 1305
++ + EE++TAV +L+ L E + + ++ + + E +L + +
Sbjct: 2247 EIQIKEESKTAVEMLQNQLKE-LNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEK 2305
Query: 1306 LQGRLALGERAE-------KESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGE 1358
L+ RL E+ + KES L+ R+ E LE+ R + A + + +GE
Sbjct: 2306 LRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGE 2365
Query: 1359 FRTRERRLLGSLEEARGTEKQQL---DHARGLELKLEAARAEAAELGLRLSAAEGRAQGL 1415
T + ++ G + RG E + L +L+ + +EL + S+ E Q
Sbjct: 2366 VETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQ-- 2423
Query: 1416 EAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLN 1475
E E +V+++ +++ A + L++ L+ L + A++ N
Sbjct: 2424 EKEQEKVQMKEKSSTA-MEMLQTQLKE---LNERVAALHNDQEACKAKEQ---------N 2470
Query: 1476 SPSTLECSPGSQPPS-PGPATSPASPDLDPEAVRGALREF---LQELRSAQRERDELRTQ 1531
S +EC + G + + + +V G ++E Q+L E L+ Q
Sbjct: 2471 LSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQ 2530
Query: 1532 TS---ALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESV 1588
L +L+++E E + +L+ E E+ + + + + +Q L + + S
Sbjct: 2531 IQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSY 2590
Query: 1589 RRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASE 1648
+ LE L+ T+ + + EK++KM A ET+L+ R + E+ +
Sbjct: 2591 KN--------------LENELELTKMDKMSFVEKVNKMTAKETELQ---REMHEMAQKTA 2633
Query: 1649 SRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV----ADSEVKAGTLQ 1704
+L ++ L GELQ + + Q + L L++ + D K G ++
Sbjct: 2634 ELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVR 2693
Query: 1705 LTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQK-ALTACEHDR 1763
+ L + E+ AL E Q+ +++++ L QK + + +
Sbjct: 2694 EEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSK 2753
Query: 1764 QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQR---VEAEGQLQQLREVLR 1820
+ L L A Q L E +K + V L+ E + + +++ QL++ +E+L+
Sbjct: 2754 EELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQ 2813
Query: 1821 QRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRR 1880
+ E + L Q+ Q ++ ++ L + +L+ E + A +L
Sbjct: 2814 K----ELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLI 2869
Query: 1881 TLDKVEREKLRSHEDTVRLSAEKGRLD 1907
+ +K+E+ K L +++ + D
Sbjct: 2870 SHEKLEKAKEMLETQVAHLCSQQSKQD 2896
Score = 158 bits (400), Expect = 4e-38
Identities = 412/2110 (19%), Positives = 838/2110 (39%), Gaps = 284/2110 (13%)
Query: 88 QELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQ 147
Q++ +E L + + E+ + + ++ LE AL+ + ++E ++ G E +R
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDS----LEAALQKQKQKVENEKTEG-TNLKRENQRL 72
Query: 148 LQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELE--QQR 205
++ ++ + K + E Q +++Q V +G++ KK+ +LEQ+L ELE QQ
Sbjct: 73 MEICESLEKTKQKISHELQVKESQ-VNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQA 131
Query: 206 LRDTEHS--------------------------QDLESALIRLEEEQQRSASLAQVNAML 239
+ + S +DL+ + EE++R A+V A+
Sbjct: 132 AQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLE--AEVKAL- 188
Query: 240 REQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREE---------------ES 284
QA A+Q L + N R + +W++E+
Sbjct: 189 -----QAKKASQTLPQ---ATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRD 240
Query: 285 FNA-YFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLS 343
F+A YFS E + R + + + F L +L ++ ++ L
Sbjct: 241 FSASYFSGEQE--VTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELE 298
Query: 344 TGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDL---AQQQMQSDLDKADLSARVT 400
L+ E + + K LQ QLE+ + + +EK L + +++ S + T
Sbjct: 299 LRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYT 358
Query: 401 ELGLAVKRL------EKQNLE--KDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQ-- 450
L +K+L ++QN E + + + + EK + + ++Q + +T D E +Q
Sbjct: 359 ALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMK 418
Query: 451 ----------QTLRDLAQAVLSDSESGVQ------------LSGSERTADASNGSLRGLS 488
+ + ++ QA L S Q L +E+ AS ++
Sbjct: 419 ARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQAS--QIKENE 476
Query: 489 GQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDL 548
+R+ ++ + + C + L I L++ Q ++M+ + + + +
Sbjct: 477 LRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETM 536
Query: 549 LGTLRKQLSDSESE--RRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKS 606
L L+++++ E+ L+ + L + D + + + +++L +E
Sbjct: 537 LRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESK 596
Query: 607 NLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELE---- 662
L +L++ +++ EEL++E+ + E + ++E E+E+ + L+
Sbjct: 597 ALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQI 656
Query: 663 RSHRQLEQ---LEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVE 719
+SH E+ LE R L+ E+ + L +++ ++ +K E KAE +
Sbjct: 657 KSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVE---VETQKLAYMELQQKAEFSDQK 713
Query: 720 LELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQE 779
+ + + + + L + L + L+ + +D +R L E +L R ++
Sbjct: 714 HQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESL--RDLLKSKD 771
Query: 780 ATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQL 839
A++ E + L +Q+ A ++ + EQ ++ + R E Q + A L
Sbjct: 772 ASLVTNEDHQRSLLAFDQQPAMHHSFANI-IGEQG--SMPSERSECRLEADQSPKNSAIL 828
Query: 840 SRQLSGREQELE---QARREAQRQVEALERAAREKEALAKEHAGLAVQLVA--AEREGRT 894
++ E LE Q + Q+Q E L + E E + + VA ++R +
Sbjct: 829 QNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKL 888
Query: 895 LSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQ 954
+ + + E L +L +++L L + E +AE Q L + L L ++
Sbjct: 889 QEDTSAHQNVVAETL-SALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL----KE 943
Query: 955 IIATQEKASLDKELMAQKLVQAEREAQ------ASLREQRAA-HEEDLQRLQREKEAA-- 1005
+ E SL+K+ M+ + +RE + +L+E A+ ++E + +Q+ + A
Sbjct: 944 LQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANY 1003
Query: 1006 WRELEAERAQLQSQLQREQEELLARLEA---EKEELSEEIAALQQER-------DEGLLL 1055
E E ++L Q ++E+ LL R E E+LS++ A Q++ +E L
Sbjct: 1004 IDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSL 1063
Query: 1056 AESEKQQALSLKES---EKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNA 1112
E+ K + LKE+ E KL + LE+E + A
Sbjct: 1064 CENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELE--------------TVQQA 1109
Query: 1113 LTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDG 1172
L SE+ D + + A QE+ L+E+ + K+ + L+E E+L ++ + ++
Sbjct: 1110 LRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQN- 1168
Query: 1173 LRRELLEAQRKLRESQEGR---------EVQR-----------QEAGELRR---SLGEGA 1209
L E + K RES+ + EV+ Q LR L E
Sbjct: 1169 LESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESE 1228
Query: 1210 KEREALRRSNEELR-----SAVKKAESERIS-LKLANEDKEQKLALLEEARTAVGKEAGE 1263
KE+E L+ + +R S ++ +S+ IS LK D E+K + +
Sbjct: 1229 KEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAH 1288
Query: 1264 LRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRE 1323
L+ LQ +L EL + ++L +E L EL + + R E +
Sbjct: 1289 LQCSLQ-------TTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGK 1341
Query: 1324 TLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLL---GSLEEARGTEKQQ 1380
L ++L ++ L + + EQ E L S E ++K+
Sbjct: 1342 LLN-EVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEV 1400
Query: 1381 LDHARGLELKLEAARAE-------AAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQL 1433
H L+ K + ++E ++ ++S + L+AE + R +
Sbjct: 1401 QMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQ--- 1457
Query: 1434 GGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGS--------GEGLNSPSTLECSPG 1485
G L ++ GL G PS + VP S + + + S ++ S LE +
Sbjct: 1458 GDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVS 1517
Query: 1486 SQPPSPGP--ATSPASPDLDPEAVRGALREFLQELRS--------AQRERDELRTQTSAL 1535
+ S +S +L + A + ++EL S ++ +++ +Q
Sbjct: 1518 ANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMK 1577
Query: 1536 NRQLAEMEAERDSATSRARQLQKA-VAESEEARRSVDGRLSGVQAELALQEESVRRSERE 1594
N+++ E+E S L+K ++E+E+ ++ + ++++LA +++ + E
Sbjct: 1578 NKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLE 1637
Query: 1595 RRATLDQVATLERSLQA-----TESELRASQEK--ISKMKANETKLEGDKRRLKEVLDAS 1647
Q+ L+ S ++ TE ++ E ISK +ET K + ++ D
Sbjct: 1638 LEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKD 1697
Query: 1648 ESRTVKLELQRRSLEGELQRSRLGLSDR----------EAQAQALQDRVDSLQRQVADSE 1697
+ + L++++ + G ++ + ++ E + Q + + L ++
Sbjct: 1698 AQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNAL 1757
Query: 1698 VKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTR--DKNLHLQKA 1755
V L E ++ +V+E+ + + + + + LN + D LHLQ+
Sbjct: 1758 VPMDFLG-NQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEV 1816
Query: 1756 LTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQL 1815
+ + + E++ + E +K++S L E+++ + +L LQRVE L
Sbjct: 1817 QLMTKIEACIELEKI------VGELKKENSDLSEKLEYFSCDHQEL-LQRVETSEGLNSD 1869
Query: 1816 REVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDR 1875
E+ + E N V K+ D +ER ++ L+++ +EK +E AL LE D
Sbjct: 1870 LEMHADKSSREDIGDN-VAKVNDS---WKERFLDVENELSRIRSEKASIEHEALYLEAD- 1924
Query: 1876 VALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLE 1935
L+ V+ EKL +D L+ L+ E + + ++ + + L+
Sbjct: 1925 ------LEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALD 1978
Query: 1936 QSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTL-- 1993
Q ++ E QE+E +S + EA + + ++ L VS L
Sbjct: 1979 Q----------LSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLK 2028
Query: 1994 -KGQLQQELR 2002
K LQ++L+
Sbjct: 2029 DKTHLQEKLQ 2038
Score = 156 bits (395), Expect = 2e-37
Identities = 261/1121 (23%), Positives = 474/1121 (42%), Gaps = 104/1121 (9%)
Query: 288 YFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQ-LGGELARTSRAVQEAGLGLSTGL 346
YFS +H LL ++V L S+++M ++ + +G +A+ + + +E L + L
Sbjct: 1848 YFSCDHQELL---QRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENEL 1904
Query: 347 RLAESRAEAALEKQAL-LQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTE---L 402
S +A++E +AL L+A LE +K+ EKD +Q + +LS +E L
Sbjct: 1905 SRIRSE-KASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQL 1963
Query: 403 GLAVKRLEKQNLEKDQVNKDLTEKLEALES-----LRLQEQAALETEDGEGLQQTLR-DL 456
+ + K+ DQ+++ + EK + LES L + A E ++ L QTL D+
Sbjct: 1964 RGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDV 2023
Query: 457 AQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACS 516
++ + + +L E+ + A + + L Q +
Sbjct: 2024 SELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKEL-------------LVK 2070
Query: 517 DSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDK 576
+S +L + L + + ++ EA+ G +LS ++ E L +++LR +
Sbjct: 2071 ESESL---QARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVR 2127
Query: 577 TDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEEL 636
+ + +++ N+ L + NL LQ++++ E + + E +A E L
Sbjct: 2128 IEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETL 2187
Query: 637 RRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALS---RAT 693
+ Q + + + D +R E E +Q+++ +G+ S L K L + L +A
Sbjct: 2188 KTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAE 2247
Query: 694 LQR--------DMLQAEKAEVAEALTKAEAGRVEL----ELSMTKLRAEEASLQDSLSKL 741
+Q +MLQ + E+ EA+ A G E+ E S+ EE L++S+ KL
Sbjct: 2248 IQIKEESKTAVEMLQNQLKELNEAVA-ALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKL 2306
Query: 742 SALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQE----RLEELRLEQ 797
A E+ + +L + + + + E L+GR E+E +AR QE E + E
Sbjct: 2307 RARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEV 2366
Query: 798 EVARQGLEG---SLRVAEQAQEALEQQLPTLRHERSQLQEQLAQL-------SRQLSGRE 847
E + +EG SLR E + + L +E + QE++++L L +E
Sbjct: 2367 ETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKE 2426
Query: 848 QELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKE 907
QE Q + ++ +E L+ +E L + A L A + + + LS + L LEK
Sbjct: 2427 QEKVQMKEKSSTAMEMLQTQLKE---LNERVAALHNDQEACKAKEQNLSSQVECLELEKA 2483
Query: 908 ALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKE 967
L L E + L++ L E + E E++ L+ QI D+E
Sbjct: 2484 QLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI--------QDQE 2535
Query: 968 LMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEEL 1027
+ KL Q E E Q +EQ +L+ L E E + L+++ A LQ L+ Q
Sbjct: 2536 QLVSKLSQVEGEHQL-WKEQNL----ELRNLTVELEQKIQVLQSKNASLQDTLEVLQSS- 2589
Query: 1028 LARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLAT 1087
LE E EL++ E+ + E+E Q+ + + L E+L G ++ LA
Sbjct: 2590 YKNLENEL-ELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAG 2648
Query: 1088 ISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGK 1147
E++ + +S ++Q + LT E +L+ + H +V + + ++ +
Sbjct: 2649 ---ELQLLLEEIKSSKDQ----LKELTLENSELKKSLD---CMHKDQVEKEGKVREEIAE 2698
Query: 1148 QRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGE 1207
+ LR E + LL D E+ + KL +E Q+ E L+ S E
Sbjct: 2699 YQ---LRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEE 2755
Query: 1208 GAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTG 1267
+A + EEL+ LK NE + K+ LL ++ + +E
Sbjct: 2756 LNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEE------- 2808
Query: 1268 LQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGL 1327
+E+ + L + QE ++ ++D++ L E+ EL+ L E KE+ E L
Sbjct: 2809 -KEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETL---EEKTKEA-DEYLDK 2863
Query: 1328 RQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLG 1368
LL LE ++ L+ L Q+ + +R LLG
Sbjct: 2864 YCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLLG 2904
Score = 152 bits (383), Expect = 4e-36
Identities = 421/2123 (19%), Positives = 823/2123 (38%), Gaps = 227/2123 (10%)
Query: 15 LETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLS------QPESPVLL 68
L+ I E+S+ ++ L DL + + RE L+ + ES LL
Sbjct: 540 LQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALL 599
Query: 69 PATEMAS--LLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEP 126
A E+ L+EE L S E LL Q +E++ L K N LE L+ +
Sbjct: 600 SALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKIN----HLETCLKTQ- 654
Query: 127 GELETQEPRGLVRQ--------SVELRR----------QLQEEQASYRRKLQAYQEGQQR 168
++++ E VR SVE+R +++ ++ +Y Q + Q+
Sbjct: 655 -QIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQK 713
Query: 169 QAQLVQRLQGKILQYKKRCSELEQQLLERSGEL------------EQQRLRDTEHSQDLE 216
+ ++ + K Q + +LE +L S E+ E + LRD S+D
Sbjct: 714 HQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKD-- 771
Query: 217 SALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEH--- 273
++L+ E+ Q+ + Q AM + G SE + CR E +
Sbjct: 772 ASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSER--------SECRLEADQSPK 823
Query: 274 REAAWRREEESFNAYFSNE---HSRLLLLWRQVVGFRRLVSEVKMFTER-------DLLQ 323
A + +S ++ +S L ++V + + E M E+ + Q
Sbjct: 824 NSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQ 883
Query: 324 LGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQ 383
+L + A Q + L E + +K QA+++E + L E L +
Sbjct: 884 RISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKE 943
Query: 384 QQMQSD---LDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLT-EKLEALESLR----- 434
Q+ S+ L+K ++S+ ++ ++ L ++N ++N L EK+ ++
Sbjct: 944 LQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANY 1003
Query: 435 LQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPS 494
+ E+ +E + +Q L Q + LS + A N L L + T
Sbjct: 1004 IDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSL 1063
Query: 495 PPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRK 554
R + + + A L + A + Q + ++ Q L +
Sbjct: 1064 CENR----KNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELE---TVQQALRSEMTD 1116
Query: 555 QLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQV 614
++S+SE L++++ L+++ + Q+EV L NE L + +
Sbjct: 1117 NQNNSKSEAGGLKQEIMTLKEEQN-------KMQKEVNDLLQENEQLMKVMKTKHECQNL 1169
Query: 615 AQQQAEELRQEREKLQ-----AAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLE 669
+ +ERE + Q +L + L+ VQ A +R + +L+
Sbjct: 1170 ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNK----ELKLQ 1225
Query: 670 QLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE----AGRVELELSMT 725
+ E ++ L EL +R L + LQ DM E + + + AE +G EL S
Sbjct: 1226 ESEKEKECLQHELQTIRGDLETSNLQ-DMQSQEISGLKDCEIDAEEKYISGPHELSTSQN 1284
Query: 726 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKS-ALQGRQRQAEQEATVAR 784
+ SLQ +++KL+ L + + + LV +L + +S + ++ AE+ +
Sbjct: 1285 DNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLN 1344
Query: 785 EEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLS 844
E + ++ L + + G EQ E L L + S E L LS
Sbjct: 1345 EVKILNDDSGLLHGELVEDIPGG-EFGEQPNEQHPVSLAPL--DESNSYEHLT-----LS 1396
Query: 845 GREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRL 904
+E ++ A E Q + +L+ E + L +H ++ ++ + +L E L
Sbjct: 1397 DKEVQMHFA--ELQEKFLSLQS---EHKILHDQHCQMSSKMSELQTYVDSLKAENLVLST 1451
Query: 905 EKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASL 964
+G L + + QL E L + + +L G+ + R + T + + L
Sbjct: 1452 NLRNFQGDLVK-EMQLGLEEGLVPSLSSSCVPDSSSLSSL-GDSSFYRALLEQTGDMSLL 1509
Query: 965 DKELMAQKLVQAEREAQASLREQ--RAAHEEDLQRLQREKEAAW--RELEAERAQLQSQL 1020
L A Q S+ E + EE+L R + A ELE+ + L
Sbjct: 1510 SN------LEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSL 1563
Query: 1021 QREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE---SEKQQALSLKESEKTALSEK 1077
++ +E++ ++ + +E+ E L ER E L + SE +Q S + K
Sbjct: 1564 EKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESK 1623
Query: 1078 LMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRR 1137
L + +SLE+E + Q RS + T + R + + + H E
Sbjct: 1624 LAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTE 1683
Query: 1138 LQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQE 1197
+ D+ + D ++ L + ++ E E Q + E + Q
Sbjct: 1684 -RTPKHDVHQICDKDAQQDLNLDIE-KITETGAVKPTGECSGEQSPDTNYEPPGEDKTQG 1741
Query: 1198 AGELRRSL---GEGAKEREALRRSNEELRSA---VKKAESERISLKLANEDKEQKL-ALL 1250
+ E L G A + E++ + VK+ +E + L ED+++K+ +LL
Sbjct: 1742 SSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLL 1801
Query: 1251 EEARTAVGK---EAGELRTGLQ---EVERSRLEARRELQELRRQMKMLDSENTRLGRELA 1304
E + K + +L T ++ E+E+ E ++E +L +++ ++ L + +
Sbjct: 1802 NEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVE 1861
Query: 1305 ELQGRLALGERAEKESRRETLG---------LRQRLLKGEASLEVMRQELQVAQRKLQEQ 1355
+G + E +S RE +G ++R L E L +R E + +
Sbjct: 1862 TSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYL 1921
Query: 1356 EGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGL 1415
E + + L ++ +K + LE +L +E +L L + L
Sbjct: 1922 EADLEVVQTEKLCLEKDNENKQKVIVC----LEEELSVVTSERNQLRGELDTMSKKTTAL 1977
Query: 1416 EAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLN 1475
+ +++ + + E+ +S + + A + + + D E L
Sbjct: 1978 DQLSEKMKEKTQELESH----QSECLHCIQVAEAEVKEKTELLQTLSSDV-----SELLK 2028
Query: 1476 SPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSAL 1535
+ L+ S + D +A+ E ++ +E++ L ++ +L
Sbjct: 2029 DKTHLQ-------------EKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESL 2075
Query: 1536 NRQLAEMEAERDSATSR-----------ARQLQKAVAESEEARRSVDGRLSGVQAELALQ 1584
+L+E + E+ + + A +L E + RR ++ ++A+ Q
Sbjct: 2076 QARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQ 2135
Query: 1585 ---EESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLK 1641
E ++ ERE + D+V LER LQ +E KA L+ +
Sbjct: 2136 LHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMA 2195
Query: 1642 EVLDASESRTVKLELQRRSLEGELQRSRLGLSDRE---AQAQALQDRVDSLQRQV-ADSE 1697
L E V L ++ +L ++Q + LS+ + + ++L + + + Q+ +S+
Sbjct: 2196 RSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESK 2255
Query: 1698 VKAGTLQLTVERLNGALAKV----------EESEGALRDKVRGLTEALAQSSASLNSTRD 1747
LQ ++ LN A+A + E+S ++ L ++ + A L +
Sbjct: 2256 TAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEK 2315
Query: 1748 KNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVE 1807
K L + + L EH +L+ R++ + L AR + + +GEV E + +
Sbjct: 2316 KQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEV---ETLKAK 2372
Query: 1808 AEGQLQQLR----EVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKRE 1863
EG Q LR +V+ R E E N +QK Q+ L+ S + L + E EK +
Sbjct: 2373 IEGMTQSLRGLELDVVTIRSEKENLT-NELQKEQERISELEIINSSFENILQEKEQEKVQ 2431
Query: 1864 V-ERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQR 1922
+ E+S+ +E L+ L ++ H D A++ L + ELE A+ +
Sbjct: 2432 MKEKSSTAME----MLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQ 2487
Query: 1923 QIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQ-QEVERLRSAQAQTERTLEARERAHRQ 1981
+ + + +VL+ S + EV+ +Q+LE + +E+ RL++ E+ + + +
Sbjct: 2488 GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGE 2547
Query: 1982 RVRGLEE--QVSTLKGQLQQELR 2002
E+ ++ L +L+Q+++
Sbjct: 2548 HQLWKEQNLELRNLTVELEQKIQ 2570
Score = 140 bits (352), Expect = 2e-32
Identities = 266/1280 (20%), Positives = 526/1280 (41%), Gaps = 230/1280 (17%)
Query: 588 QREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQ 647
Q ++ L+ + S E L H ++ ++ E L E ++L + +L Q +L +
Sbjct: 1766 QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDS---KLHLQEVQLMTKI 1822
Query: 648 EDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVA 707
E ++ LE++ G+ L KE ++ E L + L ++ E +
Sbjct: 1823 EACIE---------------LEKIVGE---LKKENSDLSEKLEYFSCDHQEL-LQRVETS 1863
Query: 708 EALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKS 767
E L S ++ A+++S +D ++ +N+S + LD+ ++++ EK+
Sbjct: 1864 EGLN-----------SDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKA 1912
Query: 768 ALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRH 827
+++ E + V + E+ LE+ ++ LE L V + L +L T+
Sbjct: 1913 SIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSK 1972
Query: 828 ERS---QLQEQLAQLSRQLSGREQE----LEQARREAQRQVEALERAAREKEALAKEHAG 880
+ + QL E++ + +++L + E ++ A E + + E L+ + + L K+
Sbjct: 1973 KTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTH 2032
Query: 881 LAVQLVAAEREGRTLS-------EEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAE 933
L +L + E++ + LS + +L EKE L +Q +L++ + + +
Sbjct: 2033 LQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKA 2092
Query: 934 GQALLLAKETLTGELAGLRQQI---------IATQEKASLDKEL-MAQKLVQAEREAQAS 983
+A L+ K L+ ++++ + + +A K+L +A+KL + ERE S
Sbjct: 2093 LEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERE-NDS 2151
Query: 984 LREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEEL----------LARLEA 1033
L+++ E +LQ + +E + E +A++++ L+ + EE+ L L +
Sbjct: 2152 LKDKVENLERELQMSEENQELVILDAENSKAEVET-LKTQIEEMARSLKVFELDLVTLRS 2210
Query: 1034 EKEELSEEIAALQQERDE--GLL-----LAESEKQQALSLKESEKTA---LSEKLMGTRH 1083
EKE L+++I Q + E LL L E ++Q + +KE KTA L +L
Sbjct: 2211 EKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNE 2270
Query: 1084 SLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRL--QEQ 1141
++A + + E K QS + + L + + LRA+ E A E ++L +Q
Sbjct: 2271 AVAALCGDQEIMKATEQS-LDPPIEEEHQLRNSIEKLRARLE------ADEKKQLCVLQQ 2323
Query: 1142 ARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGEL 1201
++ D E L R LE AR LEA+ E E + + +
Sbjct: 2324 LKESEHHADLLKGRVENLE---RELEIARTNQEHAALEAENSKGEV----ETLKAKIEGM 2376
Query: 1202 RRSLGEGAKEREALRRSNEELRSAVKKAESERIS-LKLAN--------EDKEQKLALLEE 1252
+SL + +R E L + ++K E ERIS L++ N E +++K+ + E+
Sbjct: 2377 TQSLRGLELDVVTIRSEKENLTNELQK-EQERISELEIINSSFENILQEKEQEKVQMKEK 2435
Query: 1253 ARTA---VGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGR 1309
+ TA + + EL + + + + + Q L Q++ L+ E +L + L E +
Sbjct: 2436 SSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNN 2495
Query: 1310 LALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGS 1369
+ + + GL Q + G+ LE +E+ + ++Q+QE +L+
Sbjct: 2496 YIVLQSSVN-------GLIQEVEDGKQKLEKKDEEISRLKNQIQDQE--------QLVSK 2540
Query: 1370 LEEARGTE---KQQLDHARG----LELKLEAARAEAAELGLRLSAAEGRAQGLEAELARV 1422
L + G K+Q R LE K++ +++ A L L + + LE EL
Sbjct: 2541 LSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELT 2600
Query: 1423 EVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLEC 1482
++ + + E +N + E
Sbjct: 2601 KMDKMSFV-----------------------------------------EKVNKMTAKET 2619
Query: 1483 SPGSQPPSPGPATSPASPDLDPEAVR--GALREFLQELRSAQRERDELRTQTSALNRQLA 1540
+ T+ +L E R G L+ L+E++S++ + EL + S L + L
Sbjct: 2620 ELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLD 2679
Query: 1541 EMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRA-TL 1599
M + Q++K +G+ V+ E+A + + +E++ +A L
Sbjct: 2680 CMHKD---------QVEK------------EGK---VREEIAEYQLRLHEAEKKHQALLL 2715
Query: 1600 DQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRR 1659
D E +Q +L + +E +S K L+ K L L A+ + EL++
Sbjct: 2716 DTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQ--ILEELKKT 2773
Query: 1660 SLEGELQRSRLGLSDREAQ---------AQALQDRVDSLQR-----QVADSEVKAGTLQL 1705
++ ++L + AQ + L++ + LQ+ Q A + K GT+
Sbjct: 2774 KMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMD 2833
Query: 1706 TVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQV 1765
T KV+E L +++ L E L + + + DK L + E +++
Sbjct: 2834 T---------KVDE----LTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEM 2880
Query: 1766 LQERLDAARQALSEARKQSS 1785
L+ ++ S+ KQ S
Sbjct: 2881 LETQV---AHLCSQQSKQDS 2897
Score = 124 bits (312), Expect = 7e-28
Identities = 343/1712 (20%), Positives = 670/1712 (39%), Gaps = 320/1712 (18%)
Query: 528 LHKRQLQ-VQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHED 586
L R LQ +Q++ G+ L L+K+ + + +LE LQ+ + K + +
Sbjct: 12 LPTRALQKIQELEGQ-------LDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64
Query: 587 AQREVQRLRSANELLSREKSNLAHSLQVAQQQAE----ELRQEREKLQAAQEELRRQRDR 642
+RE QRL E L + K ++H LQV + Q +L +++++ ++EL+R +
Sbjct: 65 LKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSE 124
Query: 643 LEEEQEDA-------------------------VQDGARVRRELERSHRQLEQLEG-KRS 676
LE Q+ A G++ E+ ++++E+ + +
Sbjct: 125 LERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAE 184
Query: 677 VLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE---------------------- 714
V A + + + L +AT+ + +A + + E
Sbjct: 185 VKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSAS 244
Query: 715 --AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGR 772
+G E+ S + L+ + S S+ L Q K L ++ E + LQG
Sbjct: 245 YFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGH 304
Query: 773 QRQAEQEATVAREEQERLEELRLE----QEVARQGLEGSLRVAEQAQE------ALEQQL 822
+++ + + +E Q +LE+ ++E ++V + + +R Q + ALEQ+L
Sbjct: 305 EKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKL 364
Query: 823 PTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKE----H 878
L + S Q Q A+ +R EQ++++ +E Q E L R R + L +E
Sbjct: 365 KKLTEDLS-CQRQNAESAR--CSLEQKIKEKEKEFQ---EELSRQQRSFQTLDQECIQMK 418
Query: 879 AGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQR------------QLAQLEAR 926
A L +L A+ L E +L K+ LE +L E ++ Q+ + E R
Sbjct: 419 ARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELR 478
Query: 927 REQLEAEGQALLLAKET---------LTGELAGLRQ-----QIIATQEKA---------- 962
R E + + LL + L EL ++Q Q A + KA
Sbjct: 479 RSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR 538
Query: 963 -------------SLDKELMAQKLVQAEREAQASLREQRAAHEED----LQRLQREKEAA 1005
+L+K +A ++ +R+ L ++R H E L + ++E +A
Sbjct: 539 DLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKAL 598
Query: 1006 WRELEAERAQ---------LQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLA 1056
LE ++ + L S + E E+LL ++E+EKE L +I L+ + +
Sbjct: 599 LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKS 658
Query: 1057 ESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQK------------RDAQSRQE 1104
++ +L E ++ LS ++ + L + S+E+E QK D + ++E
Sbjct: 659 HEYNERVRTL-EMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKE 717
Query: 1105 QDRSTV--NALTSELRDLRAQREEAAAAHAQEVRRLQ------EQARDLGKQRDSCLREA 1156
+ + + LT ++ DL + + + + R Q E RDL K +D+ L
Sbjct: 718 IENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTN 777
Query: 1157 EELRTQLRLLED-------------ARDGLRRELLEAQRKLRESQEGREVQRQEAGELRR 1203
E+ + L + + + E E + + +S + + + L
Sbjct: 778 EDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEF 837
Query: 1204 SLGEGAKEREALRRSNEELRSAVKKAESERISLKLANE----DKEQKLALLEEARTAVGK 1259
SL + L++ EEL + E + + ++ + Q+++ L+E +A
Sbjct: 838 SLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQN 897
Query: 1260 EAGELRTGLQEVER------SRLEARR-ELQELRRQMKMLDSE-------NTRLGRELAE 1305
E + L+ E+ ++E + E+QEL++ +L+ + L E E
Sbjct: 898 VVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKE 957
Query: 1306 LQGRLALGERAEKESRRE-------TLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGE 1358
+ ++L +R +E +E L Q + E + ++ + E +
Sbjct: 958 MSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQ 1017
Query: 1359 FRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAE 1418
++ + LL EE + L K +AA+ + ++L L+ + + E
Sbjct: 1018 YKQEKLILLQRCEETGNAYED-------LSQKYKAAQEKNSKLECLLNECTSLCENRKNE 1070
Query: 1419 LARV-EVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSP 1477
L ++ E + + L L A R L E + L S
Sbjct: 1071 LEQLKEAFAKEHQEFLTKLAFAEERNQNL-----------------MLELETVQQALRSE 1113
Query: 1478 STLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQE---LRSAQRERDELRT-QTS 1533
T + S+ + G + + ++ + + LQE L + + E + ++
Sbjct: 1114 MT-DNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESE 1172
Query: 1534 ALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSER 1593
+ + E E+ER+ + Q + E + S + +L ++A L +E ++ SE+
Sbjct: 1173 PIRNSVKERESERNQCNFKP---QMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEK 1229
Query: 1594 ERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVK 1653
E+ ++ T+ L+ + + SQE IS +K + +++ +++ + + S S+
Sbjct: 1230 EKECLQHELQTIRGDLETSNLQDMQSQE-ISGLK--DCEIDAEEKYISGPHELSTSQNDN 1286
Query: 1654 LELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGA 1713
LQ LQ + L++ E + LQ L ++ DS + T A
Sbjct: 1287 AHLQ-----CSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECIT----------A 1331
Query: 1714 LAKVEESEGALRDKVRGLTEALAQSSASL-------------NSTRDKNLHLQKALTACE 1760
K+ E G L ++V+ L + L N +L + E
Sbjct: 1332 TRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYE 1391
Query: 1761 H----DRQV------LQER---LDAARQALSEARKQSSSLGEQVQT----LRGEVADLEL 1803
H D++V LQE+ L + + L + Q SS ++QT L+ E L
Sbjct: 1392 HLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLST 1451
Query: 1804 QRVEAEGQLQQLREVLRQRQEG-----------EAAALNTVQKLQDERRLLQER-----L 1847
+G L ++E+ +EG ++++L+++ R LL++ L
Sbjct: 1452 NLRNFQGDL--VKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLL 1509
Query: 1848 GSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVER--EKLRSHEDTVRLSAEKGR 1905
+L+ A++ + EV S+ L+++ + + T + E+L S + R S EK
Sbjct: 1510 SNLEGAVSANQCSVDEVFCSS--LQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLE 1567
Query: 1906 LDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL--ELQQEVERLRS 1963
E E+Q ++ E Q LEQ S + E+D ++Q E +Q ++L S
Sbjct: 1568 ----------EKMESQGIMKNKEIQ--ELEQLLSSERQELDCLRKQYLSENEQWQQKLTS 1615
Query: 1964 AQAQTERTLEARERAHRQRVRGLEEQVSTLKG 1995
+ E L A ++ Q LE L+G
Sbjct: 1616 VTLEMESKLAAEKKQTEQLSLELEVARLQLQG 1647
Score = 105 bits (263), Expect = 3e-22
Identities = 258/1319 (19%), Positives = 518/1319 (39%), Gaps = 149/1319 (11%)
Query: 72 EMASLLSLQEENQLLQQELS-RVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELE 130
E+ S L LQE + + E +E ++ + + E +L+ K S ++ L+ +E
Sbjct: 1806 ELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQ----RVE 1861
Query: 131 TQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSEL 190
T E + +E+ + + ++R + L ++ +K E
Sbjct: 1862 TSEG---LNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSR--IRSEKASIEH 1916
Query: 191 EQQLLERSGELEQ-QRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSA 249
E LE E+ Q ++L + +++ + ++ LEEE + + LR +LD
Sbjct: 1917 EALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEEL---SVVTSERNQLRGELDTMSKK 1973
Query: 250 NQAL---SEDIRKVTNDWTRCRKELEH----REAAWRREEESFNAYFSNEHSRLLLLWRQ 302
AL SE +++ T + + E H EA + + E S++ S LL
Sbjct: 1974 TTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQT-LSSDVSELLK---- 2028
Query: 303 VVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRA-EAALEKQA 361
+ + E E+D L L + Q A L L + ES + +A L +
Sbjct: 2029 ---DKTHLQEKLQSLEKDSQALS--LTKCELENQIAQLNKEKELLVKESESLQARLSESD 2083
Query: 362 LLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNL------- 414
+ + + L ++ + + A + + + L + +L + ++ EK+ L
Sbjct: 2084 YEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLK 2143
Query: 415 EKDQVNKDLTEKLEALE-----SLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQ 469
E+++ N L +K+E LE S QE L+ E+ + +TL+ + +
Sbjct: 2144 ERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIE----------E 2193
Query: 470 LSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALH 529
++ S + + +LR T + L+ S L
Sbjct: 2194 MARSLKVFELDLVTLRSEKENLTKQIQEKQGQ------------LSELDKLLSSFKSLLE 2241
Query: 530 KRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQR 589
+++ ++ + + ++L K+L+++ + +E ++ D ++ +
Sbjct: 2242 EKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRN 2301
Query: 590 EVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQED 649
+++LR+ L + EK L QQ +E + L+ E L R+ + QE
Sbjct: 2302 SIEKLRA--RLEADEKKQLC-----VLQQLKESEHHADLLKGRVENLERELEIARTNQEH 2354
Query: 650 AVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEA 709
A + + E+E ++E + L ++V +R +++ L E + E
Sbjct: 2355 AALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRS-------EKENLTNELQKEQER 2407
Query: 710 LTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSAL 769
+++ E E + + E+ +++ K S E L +LN VA L ++ A
Sbjct: 2408 ISELEIINSSFENILQEKEQEKVQMKE---KSSTAMEMLQTQLKELNERVAALHNDQEAC 2464
Query: 770 QGRQRQAEQEATVAREEQ----ERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTL 825
+ +++ + E+ + L+E + V + + G ++ E ++ LE++ +
Sbjct: 2465 KAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEI 2524
Query: 826 RHERSQL--QEQLAQLSRQLSGREQ-------ELEQARREAQRQVEALERAARE----KE 872
++Q+ QEQL Q+ G Q EL E +++++ L+ E
Sbjct: 2525 SRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLE 2584
Query: 873 ALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEA 932
L + L +L + + + E+ ++ ++ L+ + E+ ++ A+L+ E+L
Sbjct: 2585 VLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQ---EELSG 2641
Query: 933 EGQALLLAKETLTGELAGLRQQI-IATQEKASLDKELMAQKLVQAEREAQASLREQRAAH 991
E L + L E+ + Q+ T E + L K L Q E+E + +RE+ A +
Sbjct: 2642 EKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGK--VREEIAEY 2699
Query: 992 EEDLQRLQREKEAAW----RELEAERAQLQSQLQREQEELLAR------LEAEKEELSEE 1041
+ L +++ +A ++ E E + +L ++E L ++ L++ KEEL+
Sbjct: 2700 QLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNS 2759
Query: 1042 IAALQQERDEGLLLAESEKQQALSLK-ESEKTALSEKLMGTRHSLATISLEMERQKR--- 1097
+ A Q +L E +K + +LK ++ +E+ G L ++E +K
Sbjct: 2760 LKATTQ------ILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQ 2813
Query: 1098 ----DAQSRQEQDR------STVNALTSELRDLRAQREE---AAAAHAQEVRRLQEQARD 1144
Q+ QE+ + + V+ LT+E+++L+ EE A + + L
Sbjct: 2814 KELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEK 2873
Query: 1145 LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR--EVQRQEAGELR 1202
L K ++ + L +Q + L ++ + E R Q + +G+ +
Sbjct: 2874 LEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKRLSSGQNKASGKRQ 2933
Query: 1203 RSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAG 1262
RS G R + E KKA I ED E E V K
Sbjct: 2934 RSSGIWENGRGPTPATPESFSKKSKKAVMSGIH---PAEDTEGTEFEPEGLPEVVKKGFA 2990
Query: 1263 ELRTGLQE--VERSRLEARRELQELRRQMKMLDSENTRLGRE-LAELQGRLALGERAEK 1318
++ TG + R A R L Q L LG+E LAE A G R++K
Sbjct: 2991 DIPTGKTSPYILRRTTMATRTSPRLAAQKLALSP--LSLGKENLAESSKPTAGGSRSQK 3047
Score = 103 bits (258), Expect = 1e-21
Identities = 243/1238 (19%), Positives = 494/1238 (39%), Gaps = 135/1238 (10%)
Query: 814 AQEALEQQLPTLRHERSQ-LQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKE 872
A E ++ LPT ++ Q L+ QL +L ++ R+ +L+ Q+Q + +E E
Sbjct: 4 ALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGT 63
Query: 873 ALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEA 932
L +E+ L + E+ + +S E + EG L ++Q+ +LE ++ ++
Sbjct: 64 NLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKS 123
Query: 933 EGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHE 992
E L + + A + T +K +Q ++ E L+E+
Sbjct: 124 E-----LERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYE---DLKEKYNKEV 175
Query: 993 EDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEG 1052
E+ +RL+ E +A L+A++A Q + + + + + S + + QQE+
Sbjct: 176 EERKRLEAEVKA----LQAKKAS-----QTLPQATMNHRDIARHQASSSVFSWQQEKTPS 226
Query: 1053 LLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRST--- 1109
L + S++ + + +++ +R +L + KRDA S + S+
Sbjct: 227 HLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTL-------QIGKRDANSSFFDNSSSPHL 279
Query: 1110 ---VNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLL 1166
+ A ELR+ + E H +E++ + ++L Q + + EL + ++L
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLE---KAKVELIEKEKVL 336
Query: 1167 EDARDGLRRELLE----------AQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALR 1216
RD L R + ++KL++ E QRQ A R SL + KE+E +
Sbjct: 337 NKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKE--K 394
Query: 1217 RSNEEL---RSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER 1273
EEL + + + + E I +K Q+L + + E +L + Q++E
Sbjct: 395 EFQEELSRQQRSFQTLDQECIQMKAR---LTQELQQAKNMHNVLQAELDKLTSVKQQLEN 451
Query: 1274 SRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLK 1333
+ E +++L + + + L R + E++ L + ++ RE L
Sbjct: 452 NLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHL------ 505
Query: 1334 GEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQ--LDHARGLELKL 1391
EA L+ ++Q L +Q +E + + T + +L L+E ++ L+ + L
Sbjct: 506 -EAELKNIKQCLNQSQNFAEEMKAK-NTSQETMLRDLQEKINQQENSLTLEKLKLAVADL 563
Query: 1392 EAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPS 1451
E R + +L L E + L +L++ E + ++A L L + L +
Sbjct: 564 EKQRDCSQDL---LKKREHHIEQLNDKLSKTE---KESKALLSALELKKKEYEELKEEKT 617
Query: 1452 PAPRPVPGSPARDAPAEGSGEGLNSP-STLE-CSPGSQPPSPGPATSPASPDLDPEAVRG 1509
+ E E L S + LE C Q S
Sbjct: 618 LFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKS------------------- 658
Query: 1510 ALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRS 1569
E+ + +R+ + +R+ L + L+ L E ++ +LQ+ S++ +
Sbjct: 659 --HEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQK 716
Query: 1570 VDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKAN 1629
+ ++L Q E + E + + +++ +R Q +E + ++ + A+
Sbjct: 717 EIENMCLKTSQLTGQVEDL---EHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDAS 773
Query: 1630 ETKLEGDKRRLK--EVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVD 1687
E +R L + A + ++ S+ E RL + LQ+RVD
Sbjct: 774 LVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVD 833
Query: 1688 SLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRD 1747
SL+ + + LQ E L ++EE+ L +A + + T
Sbjct: 834 SLEFSLESQKQMNSDLQKQCEELVQIKGEIEEN----------LMKAEQMHQSFVAETSQ 883
Query: 1748 KNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVE 1807
+ LQ+ +A + V+ E L AL K+ L ++V+T + E+ +L+
Sbjct: 884 RISKLQEDTSA---HQNVVAETL----SALENKEKELQLLNDKVETEQAEIQELKKSNHL 936
Query: 1808 AEGQLQQLREVLRQRQEGEAAALNTVQKL-QDERRLLQERLGSLQRALAQLEAEK----R 1862
E L++L ++L + E ++++ L + E L + G+L+ A L EK +
Sbjct: 937 LEDSLKEL-QLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQ 995
Query: 1863 EVERSALRLEKDRVALRRTLDKVEREKL----------RSHED---TVRLSAEKGRLDRT 1909
+ E A +++ ++ D+ ++EKL ++ED + + EK
Sbjct: 996 KSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLEC 1055
Query: 1910 LTGAELELAEAQR-QIQQLEAQVVVLEQSH--SPAQLEVDAQQQQLELQQEVERLRSAQA 1966
L L E ++ +++QL+ Q A E Q LEL+ + LRS
Sbjct: 1056 LLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMT 1115
Query: 1967 QTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRS 2004
+ ++ +Q + L+E+ + ++ ++ L+ +
Sbjct: 1116 DNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQEN 1153
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 190 bits (483), Expect = 1e-47
Identities = 246/1134 (21%), Positives = 478/1134 (42%), Gaps = 164/1134 (14%)
Query: 346 LRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLA 405
L+ AE E A K+ +L+E L R K+L ++ + +K DL +V
Sbjct: 840 LKSAEREKEMASMKEEF--TRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQV------ 891
Query: 406 VKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSE 465
+ E+ NL D E+ + L ++Q L+ ++++ + + + E
Sbjct: 892 --QAEQDNLA------DAEERCDQLIKNKIQ------------LEAKVKEMNERLEDEEE 931
Query: 466 SGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIH 525
+L+ +R + L+ TLA +
Sbjct: 932 MNAELTAKKRKLEDECSELK--------------------------RDIDDLELTLAKVE 965
Query: 526 SALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHE 585
H + +V+++ +++ L K+ + + + LQ DK + +A
Sbjct: 966 KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV 1025
Query: 586 DAQREVQRLRSANEL-------LSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRR 638
+++V L + E L R K L L++ Q+ +L ++++L ++
Sbjct: 1026 KLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDF 1085
Query: 639 QRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDM 698
+ + L ED G++++++L+ ++E+LE +EL R A ++ R
Sbjct: 1086 ELNALNARIEDEQALGSQLQKKLKELQARIEELE-------EELEAERTARAKVEKLRSD 1138
Query: 699 LQAEKAEVAEALTKAEAGRVELELSMTKLRA----------EEASLQDSLSKLSALNESL 748
L E E++E L +A G +++ M K R EEA+LQ + +AL +
Sbjct: 1139 LSRELEEISERLEEA-GGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATA-AALRKKH 1196
Query: 749 AQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSL 808
A +L + L+ K L+ + + + E E++ + + E + LE +
Sbjct: 1197 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQM 1256
Query: 809 RVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAA 868
E ++ + L +R++LQ + +LSRQL +E + Q R + LE
Sbjct: 1257 NEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLK 1316
Query: 869 REKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARRE 928
R+ E K LA L +A + L E+ K L+ L + ++AQ + E
Sbjct: 1317 RQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYE 1376
Query: 929 QLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQR 988
I E+ K+ +AQ+L +AE EA ++ +
Sbjct: 1377 T------------------------DAIQRTEELEEAKKKLAQRLQEAE-EAVEAVNAKC 1411
Query: 989 AAHEEDLQRLQREKEAAWRELEAERA-------------QLQSQLQREQEELLARLEAEK 1035
++ E+ RLQ E E ++E A ++ ++ +++ EE + LE+ +
Sbjct: 1412 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1471
Query: 1036 EE---LSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMG---TRHSLATIS 1089
+E LS E+ L+ +E L E+ K++ +L+E E + L+E+L T H L +
Sbjct: 1472 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQE-EISDLTEQLGSSGKTIHELEKVR 1530
Query: 1090 LEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQR 1149
++E +K + QS E+ +++ E + LRAQ E A+ R+L E+ ++ + +
Sbjct: 1531 KQLEAEKMELQSALEEAEASLEH--EEGKILRAQLE-FNQIKAEIERKLAEKDEEMEQAK 1587
Query: 1150 DSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGA 1209
+ LR + L+T L DA R E L ++K+ E+Q A + +
Sbjct: 1588 RNHLRVVDSLQTSL----DAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQV 1643
Query: 1210 KEREALRRSNE-ELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGL 1268
K ++L + + +L AV+ AN+D ++ +A++E + E ELR +
Sbjct: 1644 KSLQSLLKDTQIQLDDAVR-----------ANDDLKENIAIVERRNNLLQAELEELRAVV 1692
Query: 1269 QEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLR 1328
++ ERSR A +EL E ++++L S+NT L + ++ L+ + +E+ +E
Sbjct: 1693 EQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAE 1752
Query: 1329 QRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLE 1388
++ K +M +EL ++E + R+ ++E+ + +LD A +
Sbjct: 1753 EKAKKAITDAAMMAEEL--------KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE--Q 1802
Query: 1389 LKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRR 1442
+ L+ + + +L R+ E LEAE Q+R AE+ + G+R + RR
Sbjct: 1803 IALKGGKKQLQKLEARVRELENE---LEAE------QKRNAES-VKGMRKSERR 1846
Score = 188 bits (477), Expect = 5e-47
Identities = 278/1253 (22%), Positives = 524/1253 (41%), Gaps = 174/1253 (13%)
Query: 752 KLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVA 811
K L L+ ++ +E+ + + QA+ +AR E ++L E R V + + + V
Sbjct: 766 KAGLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVK 825
Query: 812 EQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERA-ARE 870
L ++ L RE+E+ + E R EALE++ AR
Sbjct: 826 NWPWMKLYFKIKPLLKSAE---------------REKEMASMKEEFTRLKEALEKSEARR 870
Query: 871 KEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQL 930
KE E + +L +E L+L+ +A + +L + + + QL + QL
Sbjct: 871 KEL---------------EEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQL 915
Query: 931 EAEGQAL---LLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQAS---- 983
EA+ + + L +E + EL ++++ + D + + L + E+E A+
Sbjct: 916 EAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKV 975
Query: 984 --LREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEE---L 1038
L E+ A +E + +L +EK+A LQ ++ L L+AE+++ L
Sbjct: 976 KNLTEEMAGLDEIIAKLTKEKKA---------------LQEAHQQALDDLQAEEDKVNTL 1020
Query: 1039 SEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRD 1098
++ L+Q+ D+ E EK+ + L E K L L T+ S+ +++E K+
Sbjct: 1021 TKAKVKLEQQVDDLEGSLEQEKKVRMDL-ERAKRKLEGDLKLTQESI----MDLENDKQQ 1075
Query: 1099 AQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEE 1158
R ++ +NAL + + D E+A + +LQ++ ++L + + E E
Sbjct: 1076 LDERLKKKDFELNALNARIED-----EQALGS------QLQKKLKELQARIEELEEELEA 1124
Query: 1159 LRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQ-------EAGELRRSLGEGAKE 1211
RT +E R L REL E +L E+ VQ + E ++RR L E +
Sbjct: 1125 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQ 1184
Query: 1212 REA----LRRSN-----------EELRSAVKKAESERISLKLANEDKEQKLALLEEARTA 1256
EA LR+ + + L+ +K E E+ KL +D + + +A+
Sbjct: 1185 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN 1244
Query: 1257 VGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERA 1316
+ K L + E E +R + +L Q L +EN L R+L E + ++ R
Sbjct: 1245 LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRG 1304
Query: 1317 EKESRRETLGLRQRLLKGEASLEVMRQELQVAQ------RKLQEQEGEFRTRERRLLGSL 1370
+ ++ L+++L + + + LQ A+ R+ E+E E + +R+L
Sbjct: 1305 KLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKA 1364
Query: 1371 --EEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRA 1428
E A+ K + D + E +LE A+ + A+ RL AE + + A+ + +E +
Sbjct: 1365 NSEVAQWRTKYETDAIQRTE-ELEEAKKKLAQ---RLQEAEEAVEAVNAKCSSLEKTKHR 1420
Query: 1429 AEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQP 1488
+ ++ L + R A R AE + S S LE S
Sbjct: 1421 LQNEIEDLMVDVERSNAAAAALDKKQRNFD-----KILAEWKQKYEESQSELESSQ---- 1471
Query: 1489 PSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLA-------E 1541
S + ++ A E L+ L + +RE L+ + S L QL E
Sbjct: 1472 ------KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHE 1525
Query: 1542 MEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRS--------ER 1593
+E R + +LQ A+ E+E + +G++ Q E + + R E+
Sbjct: 1526 LEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 1585
Query: 1594 ERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVK 1653
+R L V +L+ SL A E R+ E + K K+EGD ++ L + +
Sbjct: 1586 AKRNHLRVVDSLQTSLDA---ETRSRNEALRVKK----KMEGDLNEMEIQLSHANRMAAE 1638
Query: 1654 LELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGA 1713
+ Q +SL+ L+ +++ L D D L+ +A E + LQ +E L
Sbjct: 1639 AQKQVKSLQSLLKDTQIQLDDAVRAN-------DDLKENIAIVERRNNLLQAELEELRAV 1691
Query: 1714 LAKVEESEGALRDKVRGLTEAL----AQSSASLNSTRDKNLHLQKALTACEHDRQVLQER 1769
+ + E S ++ +E + +Q+++ +N + + L + T E Q +
Sbjct: 1692 VEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNA 1751
Query: 1770 LDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAA 1829
+ A++A+++A + L ++ T A LE + E Q ++++ + E E A
Sbjct: 1752 EEKAKKAITDAAMMAEELKKEQDT----SAHLERMKKNME---QTIKDLQHRLDEAEQIA 1804
Query: 1830 L----NTVQKLQDERRLLQERLGSLQRALAQ----LEAEKREVERSALRLEKDRVALRRT 1881
L +QKL+ R L+ L + Q+ A+ + +R ++ + E+DR L R
Sbjct: 1805 LKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRL 1864
Query: 1882 LDKVER--EKLRSHEDTVRLSAEKGRLDRT-LTGAELELAEAQRQIQQLEAQV 1931
D V++ K+++++ + E+ + + + EL EA+ + E+QV
Sbjct: 1865 QDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQV 1917
Score = 166 bits (419), Expect = 3e-40
Identities = 244/1157 (21%), Positives = 475/1157 (41%), Gaps = 141/1157 (12%)
Query: 65 PVLLPATEMASLLSLQEENQLLQQELSRVE------------------DLLAQSRAERDE 106
P+L A + S++EE L++ L + E DL Q +AE+D
Sbjct: 838 PLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDN 897
Query: 107 LAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQ 166
LA + ++ ++LE E E +E ++ E + +RKL+
Sbjct: 898 LADAEERCDQLIKNKIQLEAKVKEMNE-------RLEDEEEMNAELTAKKRKLEDECSEL 950
Query: 167 QRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESA----LIRL 222
+R ++ K+ + K + L E L++ + T+ + L+ A L L
Sbjct: 951 KRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL 1010
Query: 223 EEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREE 282
+ E+ + +L + L +Q+D + E +KV D R +++LE
Sbjct: 1011 QAEEDKVNTLTKAKVKLEQQVDDL----EGSLEQEKKVRMDLERAKRKLE---------- 1056
Query: 283 ESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGL 342
G +L E M E D QL L + + +
Sbjct: 1057 ----------------------GDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARI 1094
Query: 343 STGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDK--ADLSARVT 400
L + E QA ++ EE ++ R K ++++SDL + ++S R+
Sbjct: 1095 EDEQALGSQLQKKLKELQARIEELEEELEAERTARAK---VEKLRSDLSRELEEISERLE 1151
Query: 401 ELG----LAVKRLEKQNLEKDQVNKDLTE---KLEALESLRLQEQAALETEDGEGLQQTL 453
E G + ++ +K+ E ++ +DL E + EA + ++ A E GE +
Sbjct: 1152 EAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQ 1211
Query: 454 RDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQ-RTPSPPRRSSPGRGRSPRRGPS 512
R + SE ++L + + L RT + +R +
Sbjct: 1212 RVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN 1271
Query: 513 PACSDSSTLALIHSAL-----HKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALE 567
S + L + L K L Q RG+ +Q L L++QL + + AL
Sbjct: 1272 DLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQ-LEDLKRQLEEEVKAKNALA 1330
Query: 568 EQLQRLRDKTDGAMQAHE---DAQREVQR-LRSANELLSREKSNL-AHSLQVAQQQAEEL 622
LQ R D + +E +A+ E+QR L AN +++ ++ ++Q ++ E
Sbjct: 1331 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 1390
Query: 623 RQEREKLQAAQE----------ELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLE 672
++ ++LQ A+E L + + RL+ E ED + D +ERS+ L+
Sbjct: 1391 KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVD-------VERSNAAAAALD 1443
Query: 673 GKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEA 732
K+ K L E ++ + + + Q E ++ L K + E + + E
Sbjct: 1444 KKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENK 1503
Query: 733 SLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREE----QE 788
+LQ+ +S L+ S + +L ++ QLE EK LQ +A EA++ EE +
Sbjct: 1504 NLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEA--EASLEHEEGKILRA 1561
Query: 789 RLEELRLEQEVAR----------QGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ 838
+LE +++ E+ R Q LRV + Q +L+ + R++ +
Sbjct: 1562 QLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAE----TRSRNEALRVKKK 1617
Query: 839 LSRQLSGREQELEQARR---EAQRQVEALERAAREKEA----LAKEHAGLAVQLVAAERE 891
+ L+ E +L A R EAQ+QV++L+ ++ + + + L + ER
Sbjct: 1618 MEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERR 1677
Query: 892 GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 951
L E LR E E S +++L + R + L ++ +L+ K+ + +L+ L
Sbjct: 1678 NNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQL 1737
Query: 952 RQQIIATQEKASLDKELMAQKLVQAEREAQASLREQ-RAAHEEDLQRLQREKEAAWRELE 1010
+ ++ ++ +E + + A A+ +EQ +AH L+R+++ E ++L+
Sbjct: 1738 QTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAH---LERMKKNMEQTIKDLQ 1794
Query: 1011 AERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLL-LAESEKQQALSLKES 1069
+ + + ++ L +LEA EL E+ A Q+ E + + +SE++ ++
Sbjct: 1795 HRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQT 1854
Query: 1070 EKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAA 1129
E+ + L+ + + + L+++ KR A+ +EQ + ++ +L E A
Sbjct: 1855 EED--RKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADI 1912
Query: 1130 AHAQEVRRLQEQARDLG 1146
A +Q V +L+ ++RD+G
Sbjct: 1913 AESQ-VNKLRAKSRDIG 1928
Score = 157 bits (398), Expect = 8e-38
Identities = 246/1129 (21%), Positives = 469/1129 (41%), Gaps = 153/1129 (13%)
Query: 772 RQRQAEQEATVAREEQERLEELRLEQEVARQGLEG------------SLRV-AEQ----- 813
+ + E+E +EE RL+E + E R+ LE L+V AEQ
Sbjct: 841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLAD 900
Query: 814 AQEALEQ------QLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALE-- 865
A+E +Q QL E ++ E +++ +L+ ++++LE E +R ++ LE
Sbjct: 901 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELT 960
Query: 866 --RAAREKEA-------LAKEHAGLAVQLVAAEREGRTLSEEATR----LRLEKE---AL 909
+ +EK A L +E AGL + +E + L E + L+ E++ L
Sbjct: 961 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL 1020
Query: 910 EGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQ-EKASLDKEL 968
+ ++++Q+ LE EQ + L AK L G+L ++ I+ + +K LD+ L
Sbjct: 1021 TKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERL 1080
Query: 969 MAQ----KLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERA------QLQS 1018
+ + A E + +L Q ++ L+ LQ E ELEAER +L+S
Sbjct: 1081 KKKDFELNALNARIEDEQALGSQL---QKKLKELQARIEELEEELEAERTARAKVEKLRS 1137
Query: 1019 QLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKL 1078
L RE EE+ RLE S +I + ++R+ + ++A E+ AL +K
Sbjct: 1138 DLSRELEEISERLEEAGGATSVQI-EMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH 1196
Query: 1079 MGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRL 1138
+ L ++R K+ + + + + ++ +TS + Q +A A + R L
Sbjct: 1197 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME----QIIKAKANLEKMCRTL 1252
Query: 1139 QEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEA 1198
++Q + + + R +L +Q L+ L R+L E + + + G+ Q+
Sbjct: 1253 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQL 1312
Query: 1199 GELRRSLGEGAKEREALRRSNEELR------------SAVKKAESERISLKLANE----- 1241
+L+R L E K + AL + + R KAE +R+ K +E
Sbjct: 1313 EDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWR 1372
Query: 1242 -----DKEQKLALLEEARTAVGKEAGELRTGLQEV-------ERSRLEARRELQELRRQM 1289
D Q+ LEEA+ + + E ++ V E+++ + E+++L +
Sbjct: 1373 TKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV 1432
Query: 1290 K-------MLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMR 1342
+ LD + + LAE + + + + S++E L L K + + E
Sbjct: 1433 ERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL 1492
Query: 1343 QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELG 1402
+ L+ +R+ + + E + L E G+ + + + +LE AE EL
Sbjct: 1493 EHLETFKRENKNLQEE--------ISDLTEQLGSSGKTIHELEKVRKQLE---AEKMELQ 1541
Query: 1403 LRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPG-SP 1461
L AE + E ++ R +++ +A++ R + + +A R V
Sbjct: 1542 SALEEAEASLEHEEGKILRAQLEFNQIKAEIE--RKLAEKDEEMEQAKRNHLRVVDSLQT 1599
Query: 1462 ARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPAT-SPASPDLDPEAVRGALREFLQELRS 1520
+ DA E L +E A A ++++ L++ +L
Sbjct: 1600 SLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD 1659
Query: 1521 AQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAE 1580
A R D+L+ + + R+ ++AE + +L+ V ++E +R+ + L
Sbjct: 1660 AVRANDDLKENIAIVERRNNLLQAELE-------ELRAVVEQTERSRKLAEQELIETSER 1712
Query: 1581 LAL---QEESVRRSERERRATLDQVATLERSLQATESELRASQEKISK------MKANET 1631
+ L Q S+ +++ A L Q L+ ++ E R ++EK K M A E
Sbjct: 1713 VQLLHSQNTSLINQKKKMDADLSQ---LQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL 1769
Query: 1632 KLEGDKRRLKEVLDASESRTVKLELQRRSLEGE---LQRSRLGLSDREAQAQALQDRVDS 1688
K E D E + + +T+K +LQ R E E L+ + L EA+ + L++ +++
Sbjct: 1770 KKEQDTSAHLERMKKNMEQTIK-DLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEA 1828
Query: 1689 LQRQVADS---------EVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSS 1739
Q++ A+S +K T Q +R N L ++++ L+ KV+ ++
Sbjct: 1829 EQKRNAESVKGMRKSERRIKELTYQTEEDRKN--LLRLQDLVDKLQLKVKAYKRQAEEAE 1886
Query: 1740 ASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLG 1788
N+ K +Q H+ +ER D A +++ R +S +G
Sbjct: 1887 EQANTNLSKFRKVQ-------HELDEAEERADIAESQVNKLRAKSRDIG 1928
Score = 144 bits (363), Expect = 9e-34
Identities = 243/1130 (21%), Positives = 474/1130 (41%), Gaps = 151/1130 (13%)
Query: 889 EREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGEL 948
E+E ++ EE TRL KEALE S EARR++LE + +LL K L
Sbjct: 846 EKEMASMKEEFTRL---KEALEKS-----------EARRKELEEKMVSLLQEKNDL---- 887
Query: 949 AGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRE 1008
+ Q+ A Q+ + D E +L++ + + +A ++E E++ + + E A R+
Sbjct: 888 ---QLQVQAEQDNLA-DAEERCDQLIKNKIQLEAKVKEMNERLEDE-EEMNAELTAKKRK 942
Query: 1009 LEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQER---DEGLLLAESEKQQALS 1065
LE E ++L+ + + E LA++E EK ++ L +E DE + EK+ +
Sbjct: 943 LEDECSELKRDID-DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK---A 998
Query: 1066 LKESEKTALSEKLMGTRHSLATIS---LEMERQKRDAQSRQEQDRSTVNALTSELRDLRA 1122
L+E+ + AL + L + T++ +++E+Q D + EQ++ +R
Sbjct: 999 LQEAHQQALDD-LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKK-----------VRM 1046
Query: 1123 QREEAAAAHAQEVRRLQEQARDLG---KQRDSCLREAE-ELRTQLRLLEDAR---DGLRR 1175
E A +++ QE DL +Q D L++ + EL +ED + L++
Sbjct: 1047 DLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQK 1106
Query: 1176 ELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERIS 1235
+L E Q ++ E +E E +R ++ + + ++E E + EE A S +I
Sbjct: 1107 KLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT----SVQIE 1162
Query: 1236 LKLANEDKEQKLAL-LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDS 1294
+ E + QK+ LEEA A LR ++ S E ++ L+R + L+
Sbjct: 1163 MNKKREAEFQKMRRDLEEATLQHEATAAALR---KKHADSVAELGEQIDNLQRVKQKLEK 1219
Query: 1295 ENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQE 1354
E + EL ++ + ++++K +A+LE M R L++
Sbjct: 1220 EKSEFKLELDDVTSNM------------------EQIIKAKANLEKMC-------RTLED 1254
Query: 1355 QEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGR--- 1411
Q E R++ S+ + + L +L+ A ++L G+
Sbjct: 1255 QMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQL------TRGKLTY 1308
Query: 1412 AQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSG 1471
Q LE ++E + +A A L+SA R L R + A+
Sbjct: 1309 TQQLEDLKRQLEEEVKAKNALAHALQSA-RHDCDLLREQYE----------EETEAKAEL 1357
Query: 1472 EGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQ 1531
+ + S + E + T + E + L + LQE A
Sbjct: 1358 QRVLSKANSEVAQWRTKYE----TDAIQRTEELEEAKKKLAQRLQEAEEA---------- 1403
Query: 1532 TSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRS 1591
A+N + + +E + + L V S A ++D + LA ++ S
Sbjct: 1404 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1463
Query: 1592 ERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRT 1651
+ E ++ + +L L ++ S E + K L+ + L E L +S
Sbjct: 1464 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 1523
Query: 1652 VKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLN 1711
+LE R+ LE E + L + EA + + ++ L+ Q+ +++KA + E
Sbjct: 1524 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKI--LRAQLEFNQIKAEIERKLAE--- 1578
Query: 1712 GALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLD 1771
K EE E A R+ +R + ++L S + +R++ L ++K + E D ++ +L
Sbjct: 1579 ----KDEEMEQAKRNHLR-VVDSLQTSLDAETRSRNEALRVKKKM---EGDLNEMEIQLS 1630
Query: 1772 AARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALN 1831
A + +EA+KQ SL ++ + ++ D V A L++ ++ +R A L
Sbjct: 1631 HANRMAAEAQKQVKSLQSLLKDTQIQLDDA----VRANDDLKENIAIVERRNNLLQAELE 1686
Query: 1832 ----TVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVER 1887
V++ + R+L ++ L + L ++ + +++ D L+ +++ +
Sbjct: 1687 ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ 1746
Query: 1888 EKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDA 1947
E + E A+K D + EL+ + Q LE +EQ+ Q +D
Sbjct: 1747 ECRNAEE-----KAKKAITDAAMMAEELK--KEQDTSAHLERMKKNMEQTIKDLQHRLD- 1798
Query: 1948 QQQQLELQ---QEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLK 1994
+ +Q+ L+ +++++L + + E LEA ++ + + V+G+ + +K
Sbjct: 1799 EAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIK 1848
Score = 93.2 bits (230), Expect = 2e-18
Identities = 115/506 (22%), Positives = 224/506 (44%), Gaps = 59/506 (11%)
Query: 1540 AEMEAERDSATSRARQLQKAVAESEEARRSVDGRL-------SGVQAELALQEESVRRSE 1592
AE E E S +L++A+ +SE R+ ++ ++ + +Q ++ +++++ +E
Sbjct: 843 AEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAE 902
Query: 1593 RERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTV 1652
+ LE ++ L +E +++ A + KLE + LK +D E
Sbjct: 903 ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLA 962
Query: 1653 KLELQRRSLEGE---LQRSRLGL--------SDREAQAQALQDRVDSLQRQVADSEVKAG 1701
K+E ++ + E + L GL +++A +A Q +D LQ + E K
Sbjct: 963 KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAE----EDKVN 1018
Query: 1702 TLQLTVERLNGALAKVEESEGALRD--KVR-GLTEALAQSSASLNSTRDKNLHLQKALTA 1758
TL +L +V++ EG+L KVR L A + L T Q+++
Sbjct: 1019 TLTKAKVKLE---QQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLT-------QESIMD 1068
Query: 1759 CEHDRQVLQERL---DAARQALSEARKQSSSLGEQVQ----TLRGEVADLELQRVEAEGQ 1811
E+D+Q L ERL D AL+ + +LG Q+Q L+ + +LE + +EAE
Sbjct: 1069 LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELE-EELEAERT 1127
Query: 1812 LQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRL 1871
+ E LR E ++ ++L++ ++ ++ A+ + +R++E + L+
Sbjct: 1128 ARAKVEKLRSDLSRELEEIS--ERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 1185
Query: 1872 EKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQ----- 1926
E ALR+ K E L K +L++ + +LEL + ++Q
Sbjct: 1186 EATAAALRK---KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAK 1242
Query: 1927 --LEAQVVVLEQSHSPAQLEVDAQQQQL-ELQQEVERLRSAQAQTERTLEARERAHRQRV 1983
LE LE + + + + Q+ + +L + +L++ + R L+ +E Q
Sbjct: 1243 ANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT 1302
Query: 1984 RG---LEEQVSTLKGQLQQELRRSSA 2006
RG +Q+ LK QL++E++ +A
Sbjct: 1303 RGKLTYTQQLEDLKRQLEEEVKAKNA 1328
Score = 92.4 bits (228), Expect = 4e-18
Identities = 103/436 (23%), Positives = 188/436 (43%), Gaps = 82/436 (18%)
Query: 1582 ALQEESVRRSERERR--ATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRR 1639
AL++ RR E E + + L + L+ +QA + L ++E+ ++ N+ +LE +
Sbjct: 862 ALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKE 921
Query: 1640 LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVK 1699
+ E L+ E +L ++R LE D L+R + D E+
Sbjct: 922 MNERLEDEEEMNAELTAKKRKLE---------------------DECSELKRDIDDLEL- 959
Query: 1700 AGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTAC 1759
LAKVE+ + A +KV+ LTE +A L + +
Sbjct: 960 -------------TLAKVEKEKHATENKVKNLTEEMAG--------------LDEIIAKL 992
Query: 1760 EHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREV- 1818
+++ LQE A +QAL + + + ++V TL LE Q + EG L+Q ++V
Sbjct: 993 TKEKKALQE---AHQQALDDLQAEE----DKVNTLTKAKVKLEQQVDDLEGSLEQEKKVR 1045
Query: 1819 -----LRQRQEGE-AAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLE 1872
+++ EG+ ++ L+++++ L ERL L L A + + +L+
Sbjct: 1046 MDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQ 1105
Query: 1873 KDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVV 1932
K L+ ++++E E E T R EK R D EL E ++++
Sbjct: 1106 KKLKELQARIEELEEE--LEAERTARAKVEKLRSD-----LSRELEEISERLEEAGGATS 1158
Query: 1933 VLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVST 1992
V Q+E++ ++++ E Q+ L A Q E T A + H V L EQ+
Sbjct: 1159 V--------QIEMN-KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDN 1209
Query: 1993 LKGQLQQELRRSSAPF 2008
L+ +++Q+L + + F
Sbjct: 1210 LQ-RVKQKLEKEKSEF 1224
Score = 91.3 bits (225), Expect = 9e-18
Identities = 111/533 (20%), Positives = 216/533 (40%), Gaps = 49/533 (9%)
Query: 1512 REFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVD 1571
+E +++ S +E+++L+ Q A LA+ E D QL+ V E E +
Sbjct: 871 KELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEE 930
Query: 1572 GRLSGVQAELALQEESVRRSERERRATLDQV----ATLERSLQATESELRASQEKISKMK 1627
+ AEL ++ + E + +D + A +E+ ATE++++ E+++ +
Sbjct: 931 E----MNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 986
Query: 1628 ANETKLEGDKRRLKEV-------LDASESRT-------VKLELQRRSLEGELQRSRLGLS 1673
KL +K+ L+E L A E + VKLE Q LEG L++ +
Sbjct: 987 EIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRM 1046
Query: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVER----LNGALAKVEESE---GALRD 1726
D E + L+ + Q + D E L +++ LN A++E+ + L+
Sbjct: 1047 DLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQK 1106
Query: 1727 KVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSS 1786
K++ L + + L + R ++K + + + + ERL+ A A S + +
Sbjct: 1107 KLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKK 1166
Query: 1787 LGEQVQTLRGEVADLELQRVEAEGQLQQLR-EVLRQRQEGEAAALNTVQKLQDERRLLQE 1845
+ Q +R ++ + LQ L++ + + + E QKL+ E+ +
Sbjct: 1167 REAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL 1226
Query: 1846 RLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGR 1905
L + + Q+ K +E+ LE R ++ +R +L E G
Sbjct: 1227 ELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGE 1286
Query: 1906 LDRTLTGAELELAEAQR-------QIQQLEAQVV-----------VLEQSHSPAQLEVDA 1947
L R L E +++ R Q++ L+ Q+ L+ + L +
Sbjct: 1287 LSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQ 1346
Query: 1948 QQQQLELQQEVER-LRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQ 1999
+++ E + E++R L A ++ + E QR LEE L +LQ+
Sbjct: 1347 YEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE 1399
Score = 84.3 bits (207), Expect = 1e-15
Identities = 122/565 (21%), Positives = 243/565 (43%), Gaps = 104/565 (18%)
Query: 1516 QELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLS 1575
Q L Q E D++ T T A ++E + D Q +K + E A+R ++G
Sbjct: 1005 QALDDLQAEEDKVNTLTKAK----VKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEG--- 1057
Query: 1576 GVQAELALQEESVRRSERERR-----------------ATLDQVATLERSLQATESELRA 1618
+L L +ES+ E +++ A ++ L LQ EL+A
Sbjct: 1058 ----DLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 1113
Query: 1619 SQEKISK-------MKANETKLEGD-KRRLKEVL----DASESRTVKLELQRRSLEGELQ 1666
E++ + +A KL D R L+E+ +A + +V++E+ ++ E E Q
Sbjct: 1114 RIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR-EAEFQ 1172
Query: 1667 RSRLGLSD----REAQAQALQ-----------DRVDSLQR--QVADSEVKAGTLQL---- 1705
+ R L + EA A AL+ +++D+LQR Q + E L+L
Sbjct: 1173 KMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVT 1232
Query: 1706 -TVERLNGALAKVEESEGALRDKV---RGLTEALAQSSASLNSTRDK----NLHLQKALT 1757
+E++ A A +E+ L D++ R E +S L S R K N L + L
Sbjct: 1233 SNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLD 1292
Query: 1758 ACE-------HDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQ---RVE 1807
E + ++L+ ++ L E K ++L +Q+ R + L Q E
Sbjct: 1293 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETE 1352
Query: 1808 AEGQLQQL-----REVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKR 1862
A+ +LQ++ EV + R + E A+ ++L++ ++ L +RL + A+ + A+
Sbjct: 1353 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1412
Query: 1863 EVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLT-------GAEL 1915
+E++ RL+ + ++ + + RS+ L ++ D+ L ++
Sbjct: 1413 SLEKTKHRLQNE-------IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1465
Query: 1916 ELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDA-QQQQLELQQEVERLRSAQAQTERTLEA 1974
EL +Q++ + L ++ L+ ++ + ++ +++ LQ+E+ L + +T+
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHE 1525
Query: 1975 RERAHRQRVRGLEEQVSTLKGQLQQ 1999
E+ +Q LE + L+ L++
Sbjct: 1526 LEKVRKQ----LEAEKMELQSALEE 1546
Score = 77.0 bits (188), Expect = 2e-13
Identities = 76/348 (21%), Positives = 164/348 (47%), Gaps = 17/348 (4%)
Query: 1650 RTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVER 1709
++ + E + S++ E R + L EA+ + L++++ SL ++ D LQL V+
Sbjct: 841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKND-------LQLQVQA 893
Query: 1710 LNGALAKVEES-EGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQE 1768
LA EE + +++K++ L + + + L + N L E + L+
Sbjct: 894 EQDNLADAEERCDQLIKNKIQ-LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKR 952
Query: 1769 RLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAA 1828
+D L++ K+ + +V+ L E+A L+ + + + L+E +Q + A
Sbjct: 953 DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQA 1012
Query: 1829 ALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVERE 1888
+ V L + L++++ L+ +L Q + + ++ER+ +LE D + ++ +E +
Sbjct: 1013 EEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEND 1072
Query: 1889 KLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLE---QSHSPAQLEV 1945
K + E + E L+ + + ++ Q+++++L+A++ LE ++ A+ +V
Sbjct: 1073 KQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKV 1132
Query: 1946 DAQQQQL--ELQQEVERLRSAQAQTERTLE---ARERAHRQRVRGLEE 1988
+ + L EL++ ERL A T +E RE ++ R LEE
Sbjct: 1133 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE 1180
>gi|81295809 pericentrin [Homo sapiens]
Length = 3336
Score = 188 bits (477), Expect = 5e-47
Identities = 406/1811 (22%), Positives = 714/1811 (39%), Gaps = 296/1811 (16%)
Query: 347 RLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLD---------KADLSA 397
+L ++A EK+ L +L E L + +E L Q + Q +L+ K ++
Sbjct: 261 QLELTQANLQKEKETAL-TELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVL 319
Query: 398 RVTELGLAVKRLEKQNLEKD-QVNKDLTEKLEA-----LESLRLQEQAALETEDGEGLQQ 451
R + +K + +EK+ Q+ K L E E+ LE+LR + A ++E + Q
Sbjct: 320 RCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQNQ 379
Query: 452 TLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGP 511
++LA+ Q + E+ N + R L R +++ + R +
Sbjct: 380 FQKELAE----------QRAELEKIFQDKNQAERAL---RNLESHHQAAIEKLREDLQSE 426
Query: 512 SPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQ 571
C + S K QL++++++ YE + + S+ E R L QL
Sbjct: 427 HGRCLEDLEFKFKESEKEK-QLELENLQASYEDLK----------AQSQEEIRRLWSQLD 475
Query: 572 RLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQA 631
R + HE R+ +L REK+ H ++ Q + ++ R+ +
Sbjct: 476 SARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQ--HESELEQLRIYFEKKLRDAEKT 533
Query: 632 AQEELRRQRDRLEEEQEDAVQDGA----------------------------------RV 657
QE+L + RL+ +EDA+ D R
Sbjct: 534 YQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRF 593
Query: 658 RRELERSHR-QLEQLEGKRSVLAKELVEVREALSRATL---------------------- 694
+ ELE SHR QLE LE + + V R + + L
Sbjct: 594 QAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQ 653
Query: 695 --QRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDK 752
Q L+A+ A L +V+L L T+L+ E L+ L + + K
Sbjct: 654 GVQDGDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLK 713
Query: 753 LDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEE--LRLEQEVARQGLEGSLRV 810
DL ++ L E+ Q A+Q+ + ++E +R E +++E+ R+ E +
Sbjct: 714 DDLEKVKHNLIEDH---QKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLM 770
Query: 811 AEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAARE 870
+ +E E + T+ ++ + ++ QL Q + + +LE++ E Q +++ LE+
Sbjct: 771 LLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTS 830
Query: 871 KEALAKEHAGLAVQLVAAEREGRTLSE-EATRLRLEKEALEGSLFEVQRQLAQLEARREQ 929
+AL G RE T + E L ++++ + R L + + E+
Sbjct: 831 DDALHCSQCG---------REPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEK 881
Query: 930 LEAEGQALLL-AKETLTGELAGL----RQQIIATQEKASLDKELMAQKLVQAEREAQASL 984
AE A L A+E EL L +QQ+++ + + +L + Q +L
Sbjct: 882 FSAEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGAL 941
Query: 985 REQRAA-----HEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELS 1039
R A H DL L+ ++ LE+ ++ E + L L A+ EE
Sbjct: 942 LAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQL 1001
Query: 1040 EEIAALQQE--RDEGLLLAESEKQQALSLKESEKTALSEKLMGT-RHSLATISL-EMERQ 1095
+ +L Q E L + + S+++ +T +S +L GT H L + E +
Sbjct: 1002 WKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSE 1061
Query: 1096 KRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLRE 1155
K+ A +E+ T+ +++ + + +E+ + Q+ +Q +D Q S E
Sbjct: 1062 KKTALHEKEE---TLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKD---QVLSLSHE 1115
Query: 1156 AEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREAL 1215
EE R++L +L+ QR+ RE++EG + ++ S E ++AL
Sbjct: 1116 IEECRSELEVLQ-------------QRRERENREGANLLSMLKADVNLSHSERGALQDAL 1162
Query: 1216 RR----SNEELRSAV--KKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQ 1269
RR E LR+AV + ER+ L L +D LAL TA E L
Sbjct: 1163 RRLLGLFGETLRAAVTLRSRIGERVGLCL--DDAGAGLAL----STAPALEETWSDVALP 1216
Query: 1270 EVERSRLEARR-----ELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRET 1324
E++R+ E E+ R+ ++ E+ R E + + R +
Sbjct: 1217 ELDRTLSECAEMSSVAEISSHMRESFLMSPESVR------ECEQPI---RRVFQSLSLAV 1267
Query: 1325 LGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHA 1384
GL + L LE RQ E+E F+ E T + H
Sbjct: 1268 DGLMEMALDSSRQLEEARQ-----IHSRFEKEFSFKNEE------------TAQVVRKHQ 1310
Query: 1385 RGLELKLEAARAEAAELGLRLSAAEGRAQGLE---AELARVEVQRRAAEAQLGGLRSALR 1441
LE E + A+ AEL L L +G +G + A+L V + +E +L +LR
Sbjct: 1311 ELLECLKEESAAK-AELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLR 1369
Query: 1442 RGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPD 1501
R L A R EC ++ S G AT+
Sbjct: 1370 RQLQQAAQEQAALRE------------------------EC---TRLWSRGEATA----- 1397
Query: 1502 LDPEAVRGALREFLQELRSAQRE-RDELRTQTSALNRQLAEMEAERDSATSRARQLQK-- 1558
D EA ALR+ +++L Q E R + SAL Q+ +E+E + S+ R K
Sbjct: 1398 TDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQA 1457
Query: 1559 -AVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELR 1617
AV E+ S+D L Q + ++ + R ERE ++ +Q E +LR
Sbjct: 1458 EAVTALEQQVASLDKHLRN-QRQFMDEQAAEREHEREE---------FQQEIQRLEGQLR 1507
Query: 1618 --ASQEKISKMKANETKLEGD----KRRLKEVLDASESRTVKLELQRRSL---EGELQR- 1667
A + + + L+G+ +++L+E LD ++ E R + E E++R
Sbjct: 1508 QAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRL 1567
Query: 1668 SRLGLSDREAQAQALQDRVDS--------------LQRQVADSEVKAGTLQLTVER---- 1709
+ ++ R+ AQ LQ+ V+ L++Q S + A TLQ T++
Sbjct: 1568 EEMNINIRKKVAQ-LQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCP 1626
Query: 1710 -------LNGALAKVEESEGAL---RDKVRGLTEALAQSSASLNSTRDKNLHLQKALTAC 1759
G ++E ++ AL +V L E L + L S ++ LHL L
Sbjct: 1627 EPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQ 1686
Query: 1760 EHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRG-EVADLELQRVEAEGQLQQLREV 1818
V L+ +L +SS + E T+ + LQ+ +AE +++QL EV
Sbjct: 1687 NSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAE-EIEQLHEV 1745
Query: 1819 LRQRQEGEAAALNTVQKLQD------ERRLLQERLGSLQRALAQLEAEKR-EVERSALRL 1871
+ + Q + V ++ D + LL + G + Q E E E + + RL
Sbjct: 1746 IEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRL 1805
Query: 1872 EKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV 1931
D+ + +++L+ E+ L + L+R + E E+ + +IQ+ EA +
Sbjct: 1806 LADQERRHSQALEALQQRLQGAEEAAEL--QLAELERNVALREAEVEDMASRIQEFEAAL 1863
Query: 1932 VVLEQSHSPAQLEVDA-QQQQLELQQEVERLRSAQAQTERTLEAR---ERAHRQRVRGLE 1987
E + + LE+DA Q++ E+E + A A+ R LE + A ++ L
Sbjct: 1864 KAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLR 1923
Query: 1988 EQVSTLKGQLQ 1998
Q + L QLQ
Sbjct: 1924 AQCARLSRQLQ 1934
Score = 174 bits (441), Expect = 8e-43
Identities = 430/2030 (21%), Positives = 814/2030 (40%), Gaps = 285/2030 (14%)
Query: 29 QEKGLGARDLAQDAQ--ITSLPALIREIVTRNLSQPESPVLLPATEMA------SLLSLQ 80
+++G+ ++ Q+ + IT L + + + SQ + L A ++ + L L
Sbjct: 206 EQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELT 265
Query: 81 EENQLLQQE--LSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLV 138
+ N ++E L+ + ++L RA+ ELA+ + LE +E
Sbjct: 266 QANLQKEKETALTELREMLNSRRAQ--ELALLQSRQQHELELL----------REQHARE 313
Query: 139 RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERS 198
++ V LR +E A + KLQ+ E + AQ+V+ L+ K C E ++ L
Sbjct: 314 KEEVVLR--CGQEAAELKEKLQSEME---KNAQIVKTLKEDWESEKDLCLENLRKELSAK 368
Query: 199 GELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIR 258
+ E + L++ + L E++ + Q L S +QA E +R
Sbjct: 369 HQSEMEDLQNQFQKE--------LAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLR 420
Query: 259 K-VTNDWTRCRKELEHREAAWRREEE--------SFNAYFSNEHSRLLLLWRQVVGFRRL 309
+ + ++ RC ++LE + +E++ S+ + + LW Q+ R
Sbjct: 421 EDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTS 480
Query: 310 VSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEE 369
E+ E+ LARTSR L + +++ E+ LE+ L+ E+
Sbjct: 481 RQELSELHEQ-------LLARTSRVED-----LEQLKQREKTQHESELEQ---LRIYFEK 525
Query: 370 QLRD--KVLREK-DLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEK 426
+LRD K +E L QQ++Q + A L + E+GL+ LE++ ++ KD ++
Sbjct: 526 KLRDAEKTYQEDLTLLQQRLQGAREDALLDS--VEVGLSCVGLEEK---PEKGRKDHVDE 580
Query: 427 LEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRG 486
LE + E E+ Q L ES + + +D
Sbjct: 581 LEPERHKESLPRFQAELEESHRHQ----------LEALESPLCIQHEGHVSDRCCVETSA 630
Query: 487 LSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQ 546
L + P S +G ++ T +R +V + ++
Sbjct: 631 LGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADT---------ERAARVLGLETEHKVQL 681
Query: 547 DLLGT-LRKQLSDSESERRALEEQLQ---RLRDKTDGAMQ-AHEDAQREVQRLRSANELL 601
LL T L++++ + E R L +LQ RL+D + ED Q+E+ + EL+
Sbjct: 682 SLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAKQKTELM 741
Query: 602 SREKSNLAHSLQVA----QQQAEE-----LRQEREKLQAAQEELRRQRDRLEEEQEDAVQ 652
+E +V Q++AEE L + REK ++ ++ + + + E E
Sbjct: 742 KQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAEMRQLQD 801
Query: 653 DGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTK 712
A +LERS L + +G+ L ++L +AL + R+ A+ E+A AL
Sbjct: 802 QQAAQILDLERS---LTEQQGRLQQLEQDLTS-DDALHCSQCGREPPTAQDGELA-ALHV 856
Query: 713 AEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGR 772
E ++L L+ ++ E + + K SA ++ Q+ + + QL +E+ Q
Sbjct: 857 KEDCALQLMLARSRFLEERKEITE---KFSAEQDAFLQEAQEQHARELQLLQERHQQQLL 913
Query: 773 QRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAE-QAQEALEQQLPTLRHERSQ 831
AE EA Q L EL E ++QG + RVAE Q + A + RH S
Sbjct: 914 SVTAELEA----RHQAALGELTASLE-SKQGALLAARVAELQTKHAADLGALETRHLSSL 968
Query: 832 LQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAERE 891
+ LS Q RE RQ L RA E++ K+ +
Sbjct: 969 DSLESCYLSEF---------QTIREEHRQALELLRADFEEQLWKKDSLHQTI-------- 1011
Query: 892 GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 951
L++E +L+ + E +L++ R+ L E L T+ EL G+
Sbjct: 1012 ---LTQELEKLKRKHEG-------------ELQSVRDHLRTEVSTELAG--TVAHELQGV 1053
Query: 952 RQQIIATQEKASLDKELMAQKLVQAE-----REAQASLREQRAAHEEDLQRLQREKEAAW 1006
Q +++K +L ++ +L A+ +E + SL Q +Q+L+ + +
Sbjct: 1054 HQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLS 1113
Query: 1007 RELEAERAQLQSQLQREQEE------LLARLEAEKEELSEEIAALQQERDEGLLLAESEK 1060
E+E R++L+ QR + E LL+ L+A+ E ALQ L L
Sbjct: 1114 HEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETL 1173
Query: 1061 QQALSLKE--SEKTALSEKLMGTRHSLATISL------EMERQKRDAQSRQEQDRSTVNA 1112
+ A++L+ E+ L G +L+T ++ + D + + S+V
Sbjct: 1174 RAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPELDRTLSECAEMSSVAE 1233
Query: 1113 LTSELRDLRAQREEAAAAHAQEVRR-----------LQEQARDLGKQRDSCLREAEELRT 1161
++S +R+ E+ Q +RR L E A D +Q L EA ++ +
Sbjct: 1234 ISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQ----LEEARQIHS 1289
Query: 1162 QLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQE-AGELRRSLG-------EGAKERE 1213
+ ++ +++ ++L E + + E A EL ++ G E A +E
Sbjct: 1290 RFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKE 1349
Query: 1214 ALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEAR--------TAVGKEAGE-- 1263
L + V + ES R L+ A +++ AL EE TA EA E
Sbjct: 1350 VLAGKEDSEHRLVLELESLRRQLQQA---AQEQAALREECTRLWSRGEATATDAEAREAA 1406
Query: 1264 LRTGLQEVERSRLEARRELQE----LRRQMKMLDSENTRLGRELAELQGRLALGERAEKE 1319
LR ++++ + + E R++ ++ L QMK+L+SE L+ +L+ K+
Sbjct: 1407 LRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESE----------LEEQLSQHRGCAKQ 1456
Query: 1320 SRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA------ 1373
+ T L Q++ + L RQ + + + + EF+ +RL G L +A
Sbjct: 1457 AEAVT-ALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPW 1515
Query: 1374 --RGTEKQQLD-HARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAE 1430
R +++ LD L+ KL E EL ++ +A+ + E E+ R+E
Sbjct: 1516 GPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIR 1575
Query: 1431 AQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPS 1490
++ L+ + + + + + + + STL+ +PPS
Sbjct: 1576 KKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQ-----STLDAGRCPEPPS 1630
Query: 1491 PGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSAT 1550
P P P++ E + AL E+ + + ++++ + N ++ + + D
Sbjct: 1631 GSP---PEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQN 1687
Query: 1551 SRARQLQKAVAESEEARRSVDGRLSGVQ---AELALQEESVRRSERERRATLDQVATLER 1607
S+ + + E + + + R S ++ A + +E+ +R ++E+ ++Q+ +
Sbjct: 1688 SQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIE 1747
Query: 1608 SLQ------------ATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLE 1655
LQ ++S+ + Q ++ +A + + + L+ L+A E+ + L
Sbjct: 1748 KLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLA 1807
Query: 1656 LQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALA 1715
Q R L EA Q LQ ++ + Q+A+ E + VE + +
Sbjct: 1808 DQERRHSQAL----------EALQQRLQGAEEAAELQLAELERNVALREAEVEDM---AS 1854
Query: 1716 KVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQER---LDA 1772
+++E E AL+ K + E + A + L+ L A R+ L+++ A
Sbjct: 1855 RIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGA 1914
Query: 1773 ARQALSEARKQSSSLGEQVQTLRGEV--ADLELQRVEAEGQLQQLR---EVLRQRQEGEA 1827
A L R Q + L Q+Q L +EL R +A R + R +G A
Sbjct: 1915 APPELQWLRAQCARLSRQLQVLHQRFLRCQVELDRRQARRATAHTRVPGAHPQPRMDGGA 1974
Query: 1828 AALNT--VQKLQDE--RRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLD 1883
A T V+ D ++ + G LQ L L + + L ++ +++
Sbjct: 1975 KAQVTGDVEASHDAALEPVVPDPQGDLQPVLVTL-------KDAPLCKQEGVMSVLTVCQ 2027
Query: 1884 KVEREKLRSHEDTVRLSAEKG--RLDRTLTGAELELAEAQRQIQQLEAQV 1931
+ + +L ++ +RLS E G ++ L +L + Q++QL+ ++
Sbjct: 2028 RQLQSELLLVKNEMRLSLEDGGKGKEKVLEDCQLPKVDLVAQVKQLQEKL 2077
Score = 136 bits (342), Expect = 2e-31
Identities = 351/1566 (22%), Positives = 601/1566 (38%), Gaps = 250/1566 (15%)
Query: 521 LALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGA 580
L L S +H QL++ + E + L LR+ L+ ++ AL + Q
Sbjct: 250 LRLSLSNMHTAQLELTQANLQKE-KETALTELREMLNSRRAQELALLQSRQ--------- 299
Query: 581 MQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQR 640
Q E++ LR + +REK + L+ Q+ AE + + +++ + ++ +
Sbjct: 300 -------QHELELLREQH---AREKEEVV--LRCGQEAAELKEKLQSEMEKNAQIVKTLK 347
Query: 641 DRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ 700
+ E E++ +++ +R+EL H+ ++E ++ KEL E R L + + +D Q
Sbjct: 348 EDWESEKDLCLEN---LRKELSAKHQS--EMEDLQNQFQKELAEQRAELEK--IFQDKNQ 400
Query: 701 AEKAEVAEALTKAEAG-RVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLV 759
AE+A L E+ + +E L++E + L ES + +L+L L
Sbjct: 401 AERA-----LRNLESHHQAAIEKLREDLQSEHGRCLEDLE--FKFKESEKEKQLELENLQ 453
Query: 760 AQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALE 819
A E+ K+ Q R+ + AR ++ L EL EQ +AR L E L+
Sbjct: 454 ASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELH-EQLLARTSRVEDL-------EQLK 505
Query: 820 QQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHA 879
Q+ E++Q + +L QL + ++ E+ +E ++ + ARE L
Sbjct: 506 QR------EKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEV 559
Query: 880 GLA-VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALL 938
GL+ V L +GR + LE E + SL Q +L E+ R QLEA L
Sbjct: 560 GLSCVGLEEKPEKGRKDHVD----ELEPERHKESLPRFQAELE--ESHRHQLEALESPLC 613
Query: 939 LAKETLTGELAGLRQQIIA-----------TQEKASLDKELMAQKLVQAEREAQASLREQ 987
+ E + + + +QE + + + ++A+ E A +
Sbjct: 614 IQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGL 673
Query: 988 RAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQ 1047
H+ L LQ E + L+ E L +LQ E L LE K L E+ Q+
Sbjct: 674 ETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETR-LKDDLEKVKHNLIEDH---QK 729
Query: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQK----------- 1096
E + E KQ+ KE++ + E+L T+ L R+K
Sbjct: 730 ELNNAKQKTELMKQE-FQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINK 788
Query: 1097 ---RDAQSRQEQDRSTVNALTSE---------LRDLRAQREEAAAAHAQEVRRLQEQARD 1144
R+A+ RQ QD+ L E L+ L A H + R A+D
Sbjct: 789 FELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQD 848
Query: 1145 LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEG--REVQRQEAGELR 1202
+ L E+ QL L AR E E K Q+ +E Q Q A EL+
Sbjct: 849 ---GELAALHVKEDCALQLML---ARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQ 902
Query: 1203 RSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAG 1262
L E + ++ L EL + + A E ++ L ++ A + E +T + G
Sbjct: 903 L-LQE--RHQQQLLSVTAELEARHQAALGE-LTASLESKQGALLAARVAELQTKHAADLG 958
Query: 1263 ELRTG------------LQEVERSRLEARRELQELR----RQMKMLDS-ENTRLGRELAE 1305
L T L E + R E R+ L+ LR Q+ DS T L +EL +
Sbjct: 959 ALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEK 1018
Query: 1306 L----QGRL-ALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRK-----LQEQ 1355
L +G L ++ + E E G L+G E ++ K LQ
Sbjct: 1019 LKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSA 1078
Query: 1356 EGE-FRTRERRLLGSLEEARGTEKQQL-DHARGLELKLEAARAEAAELGLRLSAAEGRAQ 1413
+ + F E+ L + + + QQL D L ++E R+E L R
Sbjct: 1079 QAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGA 1138
Query: 1414 GLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEG 1473
L L+ ++ + ++ G L+ ALRR LGL G R A S G
Sbjct: 1139 NL---LSMLKADVNLSHSERGALQDALRRLLGLF-----------GETLRAAVTLRSRIG 1184
Query: 1474 LNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTS 1533
L+ + S PA D+ AL E
Sbjct: 1185 ERVGLCLDDAGAGLALSTAPALEETWSDV-------ALPE-------------------- 1217
Query: 1534 ALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSER 1593
L+R L+E AE S + ++++ S E+ R + + V L+L + +
Sbjct: 1218 -LDRTLSEC-AEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEM-- 1273
Query: 1594 ERRATLDQVATLERSLQATESELRASQEKISKMKANET-KLEGDKRRLKEVLDASESRTV 1652
LD LE + Q + + EK K ET ++ + L E L +
Sbjct: 1274 ----ALDSSRQLEEARQ-----IHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKA 1324
Query: 1653 KLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNG 1712
+L L+ +G L+ ++ +D L+ +A E L L +E L
Sbjct: 1325 ELALELHKTQGTLEGFKVETAD--------------LKEVLAGKEDSEHRLVLELESLRR 1370
Query: 1713 ALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDA 1772
L + + + ALR++ T ++ A+ + L+K + ++ +++ +
Sbjct: 1371 QLQQAAQEQAALREEC---TRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEK 1427
Query: 1773 ARQAL-SEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLR-QRQEGEAAAL 1830
R AL S+ + S L EQ+ RG E E Q+ L + LR QRQ + A
Sbjct: 1428 DRSALLSQMKILESELEEQLSQHRGCAKQAEAVTA-LEQQVASLDKHLRNQRQFMDEQAA 1486
Query: 1831 NTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKL 1890
+ ++ ++ +Q G L++A R+ +++ L E + L + REKL
Sbjct: 1487 EREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVE------LLQQKLREKL 1540
Query: 1891 RSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQ 1950
+ ++ A RQ+ E ++ LE+ + ++ +++
Sbjct: 1541 DEFNELA-----------------IQKESADRQVLMQEEEIKRLEE------MNINIRKK 1577
Query: 1951 QLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPFSP 2010
+LQ+EVE+ ++ E + +E +Q++ L L LQ L P P
Sbjct: 1578 VAQLQEEVEKQKNIVKGLE---QDKEVLKKQQMSSL-----LLASTLQSTLDAGRCPEPP 1629
Query: 2011 PSGPPE 2016
PPE
Sbjct: 1630 SGSPPE 1635
Score = 115 bits (287), Expect = 6e-25
Identities = 303/1351 (22%), Positives = 526/1351 (38%), Gaps = 210/1351 (15%)
Query: 774 RQAEQEATVAREEQE--RLEELRLEQEVARQGLE-GSLRVAEQAQEALEQQLPTLRHERS 830
++ EQE +A + E R +E L Q A GLE +LR++ + +L T + +
Sbjct: 213 KECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLEL-TQANLQK 271
Query: 831 QLQEQLAQLSRQLSGRE-QELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAE 889
+ + L +L L+ R QEL + Q ++E L RE+ A KE L AAE
Sbjct: 272 EKETALTELREMLNSRRAQELALLQSRQQHELELL----REQHAREKEEVVLRCGQEAAE 327
Query: 890 REGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELA 949
+ + SE ++ K E +E ++ L LE R++L A+ Q+ E+
Sbjct: 328 LKEKLQSEMEKNAQIVKTLKED--WESEKDLC-LENLRKELSAKHQS----------EME 374
Query: 950 GLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRL----QREKEAA 1005
L+ Q +K ++ +K+ Q + +A+ +LR + H+ +++L Q E
Sbjct: 375 DLQNQF----QKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRC 430
Query: 1006 WRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERD-------------EG 1052
+LE + + + + Q E E L A E K + EEI L + D E
Sbjct: 431 LEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQ 490
Query: 1053 LLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNA 1112
LL S + LK+ EKT +L R + E++ RDA+ ++D
Sbjct: 491 LLARTSRVEDLEQLKQREKTQHESELEQLR-------IYFEKKLRDAEKTYQED------ 537
Query: 1113 LTSELRDLRAQREEAAAAHAQ---EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDA 1169
LT + L+ RE+A + L+E+ K L + R +
Sbjct: 538 LTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAEL 597
Query: 1170 RDGLRRELLEAQRKLRESQEGRE-----VQRQEAG-ELRRSLGEGAKE----------RE 1213
+ R +L + L EG V+ G E R EG + ++
Sbjct: 598 EESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQD 657
Query: 1214 ALRRSNEELRSAVKKAESE-RISLKLANEDKEQKLALLE-EARTAVGKEAGE--LRTGLQ 1269
++ E + V E+E ++ L L + ++++ LL+ E R GK E L+ L+
Sbjct: 658 GDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLE 717
Query: 1270 EVERSRLE-ARRELQELRRQMKMLDSENTR-----------LGRELAELQGRLALGERAE 1317
+V+ + +E ++EL +++ +++ E R L RE E + L R +
Sbjct: 718 KVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREK 777
Query: 1318 KESRRETLGLRQRLLKGEASLEVMRQELQV--AQRKLQEQEGEFRTRERRLL-------- 1367
ES ++T+ + L + E +Q Q+ +R L EQ+G + E+ L
Sbjct: 778 AESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCS 837
Query: 1368 -----------GSLEEARGTE----KQQLDHARGLELKLEAARAEAAELGLRLSAA---- 1408
G L E + L +R LE + E +AE L A
Sbjct: 838 QCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQH 897
Query: 1409 --------EGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGS 1460
E Q L + A +E + +AA LG L ++L G A A +
Sbjct: 898 ARELQLLQERHQQQLLSVTAELEARHQAA---LGELTASLESKQGALLAARVA--ELQTK 952
Query: 1461 PARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRS 1520
A D A + L+S +LE S + + +R R+ L+ LR+
Sbjct: 953 HAADLGALET-RHLSSLDSLESCYLS----------------EFQTIREEHRQALELLRA 995
Query: 1521 AQRE----RDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSG 1576
E +D L + L ++L +++ + + R + +E A +V L G
Sbjct: 996 DFEEQLWKKDSL--HQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELA-GTVAHELQG 1052
Query: 1577 VQAELALQEESVRRSERERRATLDQVATLERSLQATES---ELRASQEKISKMKANETKL 1633
V E+ E+E L + ES +L+ ++ ++K L
Sbjct: 1053 VHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSL 1112
Query: 1634 EGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQV 1693
+ + L+ + R E + R L + ++ ++ ALQD + L
Sbjct: 1113 SHEIEECRSELEVLQQRR---ERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLF 1169
Query: 1694 ADSEVKAGTLQ--------LTVERLNGALA-----KVEE--SEGALRDKVRGLTEALAQS 1738
++ A TL+ L ++ LA +EE S+ AL + R L+E S
Sbjct: 1170 GETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPELDRTLSECAEMS 1229
Query: 1739 SASLNST--RDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRG 1796
S + S+ R+ L +++ CE + + + L A L E SS E+ + +
Sbjct: 1230 SVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHS 1289
Query: 1797 ----EVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQR 1852
E + + + + Q+L E L++ +A + K Q + L+
Sbjct: 1290 RFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKE 1349
Query: 1853 ALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTG 1912
LA E + R L LE +LRR L + +E+ E+ RL + R + T T
Sbjct: 1350 VLAGKEDSE---HRLVLELE----SLRRQLQQAAQEQAALREECTRLWS---RGEATATD 1399
Query: 1913 AELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQ---QQQLELQQEVERLRSAQAQTE 1969
AE A +++++ L EQS + Q E D Q L+ E+E S
Sbjct: 1400 AEAREAALRKEVEDL-----TKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCA 1454
Query: 1970 RTLEARERAHRQRVRGLEEQVSTLKGQLQQE 2000
+ EA V LE+QV++L L+ +
Sbjct: 1455 KQAEA--------VTALEQQVASLDKHLRNQ 1477
Score = 83.6 bits (205), Expect = 2e-15
Identities = 152/693 (21%), Positives = 289/693 (41%), Gaps = 90/693 (12%)
Query: 364 QAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDL 423
+ L + +++ +E+++ ++Q L +DL + L +RLEK E+ DL
Sbjct: 2450 RGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLL----ERLEKIIREQG----DL 2501
Query: 424 TEKLEALESLRLQEQAALETE--------------DGEGLQQTLRDLAQAVLSDSESGVQ 469
EK +LE LRL ++++L +E + E LQ L A S+ Q
Sbjct: 2502 QEK--SLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQ 2559
Query: 470 LSGSERTADASNGSLRGLSG--QRTPSPPRRSS-------PGRGRSPRRGPSPACSDSST 520
L + ++G Q+T S + + R S C
Sbjct: 2560 LRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQK 2619
Query: 521 LALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRAL-----EEQLQRLRD 575
+ +L + Q +V +R + ++ L ++L + + RAL EEQL+ L+
Sbjct: 2620 SEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQR 2679
Query: 576 KTDGAMQAHE-DAQREVQRLRSANELLSRE-----KSNLAHSLQVAQQQAEEL-RQEREK 628
++ A E A E QR +S+ ++ + K NL L++ + E L QER +
Sbjct: 2680 ESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQ 2739
Query: 629 LQAAQEELRRQR------------DRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRS 676
L Q++L ++ +RL EQ A V ++ + H L++L+ ++S
Sbjct: 2740 LSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKS 2799
Query: 677 VLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQD 736
+ + + +A + L+AE + EAL + + L+ ++ L ++ L+
Sbjct: 2800 RVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRC 2859
Query: 737 SLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLE 796
SL + E A + +L + +L+E++ R+A + + AR+ E+ R
Sbjct: 2860 SLER---EREKPAWLQAELEQSHPRLKEQEG------RKAARRSAEARQSPAAAEQWRKW 2910
Query: 797 QEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSR--QLSGREQELEQAR 854
Q R E+ +E LE Q H+ QLQ+ + L ++ G L AR
Sbjct: 2911 Q-----------RDKEKLRE-LELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSAR 2958
Query: 855 REAQRQVEALERAAREKEALAKEHAGLAVQLVA--AEREGRTLSEEATRLRLEKEALEGS 912
R A + L RE EA+ + A L + ++ RT+++ + +L +
Sbjct: 2959 RAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHT 3018
Query: 913 LFEVQRQLAQLEARREQLEAEGQ-----ALLLAKETLTGELAGLRQQIIATQEKASLDKE 967
L E++ L++ + ++++ AE Q LL +LT L+ + Q+ + S ++
Sbjct: 3019 LEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEK 3078
Query: 968 LM---AQKLVQAEREAQASLREQRAAHEEDLQR 997
L+ QK R +++ + A + L+R
Sbjct: 3079 LLKHHLQKGCSPSRSERSAWKPDETAPQSSLRR 3111
Score = 80.1 bits (196), Expect = 2e-14
Identities = 178/778 (22%), Positives = 301/778 (38%), Gaps = 140/778 (17%)
Query: 816 EALEQQLPTLRHERSQLQ------EQLAQLSRQLSGREQELEQARREAQRQVEALERA-A 868
EA++++ +H ++ LQ Q+ LS L+ E R+E + Q +L
Sbjct: 2380 EAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGGKT 2439
Query: 869 REKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEAR-R 927
+E + G +Q+V +E +E + L+ L L +LE R
Sbjct: 2440 QEVPTACPDWRGDLLQVV---QEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIR 2496
Query: 928 EQLEAEGQAL----LLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQAS 983
EQ + + ++L L + +L E+ LR Q+ T L Q+ +Q R A S
Sbjct: 2497 EQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTH--------LQNQEKLQHLRTALTS 2548
Query: 984 LREQRAAHEEDLQRLQREKEAAWRELEAERA---QLQSQLQREQEE------LLARLEAE 1034
E R + +E +L+R+ E ++E E+ LQ L EQE+ LLA +
Sbjct: 2549 A-EARGSQQE--HQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTV 2605
Query: 1035 KEELSEEIAALQQERDEGLLLAESEKQQA-------LSLKESEKTALSEKLMGTRHSLAT 1087
+L ++ +Q + E L + E QQ LS KE+E A ++L +
Sbjct: 2606 VRDLKSDLCESRQ-KSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRA 2664
Query: 1088 ISLEMERQKRDAQSRQEQDRSTVNALTSEL-------------------------RDLRA 1122
+ ++E ++ R+ Q + L + L ++LR
Sbjct: 2665 LQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRI 2724
Query: 1123 QREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLE--------------- 1167
+ A AQE +L E +DL ++ L +E LR + L E
Sbjct: 2725 EHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDT 2784
Query: 1168 DARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSL-GEGAKEREALRRSNE---ELR 1223
A L ++L E + ++ + Q E +Q+A ++ L E K EALRR E L+
Sbjct: 2785 QAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLK 2844
Query: 1224 SAVKKAESERISLKLANEDKEQKLALL-------------EEARTAVGKEAGELRT---- 1266
S V+ +++ L+ + E + +K A L +E R A + A ++
Sbjct: 2845 STVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAA 2904
Query: 1267 -----------GLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGER 1315
L+E+E R ++++L++ ++ L+S++ G L R A G
Sbjct: 2905 EQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSD 2964
Query: 1316 AE--KESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA 1373
A+ +E +RE +RQRLL L Q R + + LL +LEE
Sbjct: 2965 ADHLREQQRELEAMRQRLLSAARLLTSFTS--QAVDRTVNDWTSSNEKAVMSLLHTLEEL 3022
Query: 1374 RGTEKQQLDHARGLELKLEAARAEAAELGLR-LSAAEGRAQGLEAELARVEVQRRAAEAQ 1432
K L + K+ AAEL + + L L+ V ++
Sbjct: 3023 ----KSDLSRPTSSQKKM------AAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRA 3072
Query: 1433 LGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPS 1490
+ L L+ L G +PS + R P AP L P PG PP+
Sbjct: 3073 VSKLEKLLKHHLQKGCSPSRSERSA-WKPDETAPQ----SSLRRP-----DPGRLPPA 3120
Score = 75.5 bits (184), Expect = 5e-13
Identities = 136/545 (24%), Positives = 238/545 (43%), Gaps = 75/545 (13%)
Query: 1505 EAVRGALR-------EFLQELRSAQRERDELRTQTS-ALNRQLAEMEAERDSATSRARQL 1556
+A+R LR E LQ LR+A + +Q L RQ+ + + + A L
Sbjct: 2522 QALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDL 2581
Query: 1557 QKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESEL 1616
QK ++E +E + + VQ LA ++ VR + + + + L RSL + E+
Sbjct: 2582 QKTLSEEQE-------KANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEV 2634
Query: 1617 RASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDRE 1676
+ +S K NE LK L ES K R+L+ +L+ +L RE
Sbjct: 2635 LQLRSMLSS-KENE---------LKAALQELESEQGK----GRALQSQLEEEQLRHLQRE 2680
Query: 1677 AQ-AQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVR---GLT 1732
+Q A+AL++ SL+ Q A S RL AL + ++ L+ ++R
Sbjct: 2681 SQSAKALEELRASLETQRAQS-----------SRLCVALKHEQTAKDNLQKELRIEHSRC 2729
Query: 1733 EALAQSSASLNSTRDKNLHLQKALT-----ACEHDRQVLQERLDAARQALSEARKQS-SS 1786
EAL S S K+L +K+ T A H+R + ++ ++A Q+ +
Sbjct: 2730 EALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHA 2789
Query: 1787 LGEQVQTLRGEVADLE--LQRV---------EAEGQLQQLREVLRQRQEGEAAALNTVQK 1835
L ++++ + V DL+ L++V + E + Q+ E LR+ +E A +TV+
Sbjct: 2790 LLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEA 2849
Query: 1836 LQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHED 1895
L ++R L+ L + A L+AE E L+ ++ R A RR+ + R+ + E
Sbjct: 2850 LHTQKRELRCSLEREREKPAWLQAE-LEQSHPRLKEQEGRKAARRSAE--ARQSPAAAEQ 2906
Query: 1896 TVRLSAEKGRLDRTLTGAELEL---AEAQRQIQQLEAQVVV------LEQSHSPAQLEVD 1946
+ +K +L + +L + Q+ ++ LE++ V L + A + D
Sbjct: 2907 WRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDAD 2966
Query: 1947 -AQQQQLELQQEVERLRS-AQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRS 2004
++QQ EL+ +RL S A+ T T +A +R E+ V +L L++
Sbjct: 2967 HLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDL 3026
Query: 2005 SAPFS 2009
S P S
Sbjct: 3027 SRPTS 3031
Score = 70.5 bits (171), Expect = 2e-11
Identities = 118/494 (23%), Positives = 212/494 (42%), Gaps = 73/494 (14%)
Query: 1518 LRSAQRERDELRTQTSALNRQLAEMEAE----RDSATSRARQLQKAVAESEEAR---RSV 1570
+R + + E R ++ L+R L E++ E R +S+ +L+ A+ E E + R++
Sbjct: 2606 VRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRAL 2665
Query: 1571 DGRLSGVQAELALQEESVRRSERERRATLD-QVATLERSLQATESELRASQEKISKMKAN 1629
+L Q +E ++ E RA+L+ Q A R A + E A +++
Sbjct: 2666 QSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIE 2725
Query: 1630 ETKLEG----DKRRLKEV---LDASESRTVKL------------ELQRRSLEGELQRSRL 1670
++ E ++ +L E+ L A +SRT++L +L +R+ E + +
Sbjct: 2726 HSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQ 2785
Query: 1671 G-------LSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGA 1723
L + +++ LQ ++ +Q+Q S+ + L+ ++ AL + +E
Sbjct: 2786 AHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQ---LEAEAQKHCEALRREKEVSAT 2842
Query: 1724 LRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQ 1783
L+ V L + SL R+K LQ L H R QE AAR++ +EAR Q
Sbjct: 2843 LKSTVEALHTQKRELRCSLEREREKPAWLQAELEQ-SHPRLKEQEGRKAARRS-AEAR-Q 2899
Query: 1784 SSSLGEQV---QTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDER 1840
S + EQ Q + ++ +LELQR +++QL++ +R + +DE
Sbjct: 2900 SPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLES------------KDEV 2947
Query: 1841 RLLQERLGSLQRALA----QLEAEKREVERSALRLEKDRVAL----RRTLDKVEREKLRS 1892
+ LGS +RA L ++RE+E RL L + +D+ + S
Sbjct: 2948 PGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSS 3007
Query: 1893 HEDTV-----RLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDA 1947
+E V L K L R + + AE Q Q V+L+ + S +
Sbjct: 3008 NEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVD-----VLLKDNVSLTKALSTV 3062
Query: 1948 QQQQLELQQEVERL 1961
Q++LEL + V +L
Sbjct: 3063 TQEKLELSRAVSKL 3076
Score = 59.3 bits (142), Expect = 4e-08
Identities = 157/719 (21%), Positives = 277/719 (38%), Gaps = 177/719 (24%)
Query: 81 EENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQA-LRLEPGELETQEPRGLVR 139
+E L L LL++ +A R +L + + E+L+ L E + +R
Sbjct: 2502 QEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLR 2561
Query: 140 QSVEL---------------RRQLQEEQA---SYRRKLQAYQ-----------EGQQRQA 170
+ VEL ++ L EEQ S ++ L A Q E +Q+
Sbjct: 2562 RQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSE 2621
Query: 171 QLVQRL---QGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIR-LEEEQ 226
QL + L Q ++LQ + S E +L ELE ++ + LE +R L+ E
Sbjct: 2622 QLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRES 2681
Query: 227 QRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFN 286
Q + +L ++ A L Q Q+ +R L+H + A +++
Sbjct: 2682 QSAKALEELRASLETQRAQS------------------SRLCVALKHEQTA----KDNLQ 2719
Query: 287 AYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGL 346
EHSR L Q R +SE++ L E +RT L
Sbjct: 2720 KELRIEHSRCEALLAQE---RSQLSELQK-------DLAAEKSRT--------------L 2755
Query: 347 RLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAV 406
L+E AL + LL QL ++ ++ + + A + L + +RV +L +
Sbjct: 2756 ELSE-----ALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEE--KSRVVDLQAML 2808
Query: 407 KRLEKQNL-EKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSE 465
+++++Q L + Q+ + + EAL R +E +A E L R+L ++ + E
Sbjct: 2809 EKVQQQALHSQQQLEAEAQKHCEALR--REKEVSATLKSTVEALHTQKRELRCSLERERE 2866
Query: 466 SGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIH 525
L + + S+ L+ G++ RRS+ R SPA ++
Sbjct: 2867 KPAWL---QAELEQSHPRLKEQEGRKA---ARRSAEAR-------QSPAAAEQ------- 2906
Query: 526 SALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHE 585
RK D E R E +LQR RD + +
Sbjct: 2907 --------------------------WRKWQRDKEKLR---ELELQRQRD-----LHKIK 2932
Query: 586 DAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEE 645
Q+ V+ L S +E + + +L + + A A+ LR+++ +L+A ++ L L
Sbjct: 2933 QLQQTVRDLESKDE-VPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTS 2991
Query: 646 EQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAE 705
AV R + S+ E L L E++ LSR T + + AE
Sbjct: 2992 FTSQAVD---RTVNDWTSSN------EKAVMSLLHTLEELKSDLSRPTSSQKKMAAE--- 3039
Query: 706 VAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEE 764
+ + + L+D++S AL+ ++ Q+KL+L+R V++LE+
Sbjct: 3040 -------------------LQFQFVDVLLKDNVSLTKALS-TVTQEKLELSRAVSKLEK 3078
Score = 46.2 bits (108), Expect = 3e-04
Identities = 70/272 (25%), Positives = 115/272 (42%), Gaps = 44/272 (16%)
Query: 1759 CEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEV-----ADLELQRV----EAE 1809
CE + ++ L++ R+ + + + G +++ LR + A LEL + E E
Sbjct: 215 CEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKE 274
Query: 1810 GQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSAL 1869
L +LRE+L R+ E A L + Q Q E LL+E+ RE E L
Sbjct: 275 TALTELREMLNSRRAQELALLQSRQ--QHELELLREQ-------------HAREKEEVVL 319
Query: 1870 RLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELEL-AEAQRQIQQLE 1928
R ++ L+ L E EK T++ E + D L EL A+ Q +++ L+
Sbjct: 320 RCGQEAAELKEKLQS-EMEKNAQIVKTLKEDWESEK-DLCLENLRKELSAKHQSEMEDLQ 377
Query: 1929 AQVV--VLEQSHSPAQLEVDAQQQQLEL-------QQEVERLRS-AQAQTERTLE----- 1973
Q + EQ ++ D Q + L Q +E+LR Q++ R LE
Sbjct: 378 NQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFK 437
Query: 1974 --ARERAHRQRVRGLEEQVSTLKGQLQQELRR 2003
E+ + + L+ LK Q Q+E+RR
Sbjct: 438 FKESEKEKQLELENLQASYEDLKAQSQEEIRR 469
Score = 37.4 bits (85), Expect = 0.15
Identities = 47/216 (21%), Positives = 90/216 (41%), Gaps = 29/216 (13%)
Query: 72 EMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLE---QALRLEPGE 128
E + ++ LQ + +QQ+ + L + E + VS L+ +AL + E
Sbjct: 2797 EKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRE 2856
Query: 129 L------ETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQ 182
L E ++P L + + +L+E++ + A + + RQ+ K +
Sbjct: 2857 LRCSLEREREKPAWLQAELEQSHPRLKEQEG----RKAARRSAEARQSPAAAEQWRKWQR 2912
Query: 183 YKKRCSELEQQLLERSGELE-----QQRLRDTEHSQDLESALIRLEEEQQRSASLA---- 233
K++ ELE L+R +L QQ +RD E ++ + + L ++ + S A
Sbjct: 2913 DKEKLRELE---LQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLR 2969
Query: 234 ----QVNAMLREQLDQAGSANQALSEDIRKVTNDWT 265
++ AM + L A S+ + + NDWT
Sbjct: 2970 EQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWT 3005
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 186 bits (472), Expect = 2e-46
Identities = 394/1952 (20%), Positives = 809/1952 (41%), Gaps = 283/1952 (14%)
Query: 7 RAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPESPV 66
+ Q E++LET Q +E L Q L +DL Q Q + L R +VT
Sbjct: 356 KKQLEEVSLETRAQAMEKDQLAQL--LEEKDLLQKVQNEKIENLTRMLVT---------- 403
Query: 67 LLPATEMASLLSLQEENQLLQQE-----LSRVEDLLAQSRAERDELAIKYNAVSERLEQA 121
+S L+LQ+E + ++ L ++ + + A++ + + +L
Sbjct: 404 -------SSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSIN 456
Query: 122 LRLEPGELETQE-----------------PRGLVRQSVELRRQLQEEQASYRRKLQAYQE 164
L E E E P + + +L +A Y + Y++
Sbjct: 457 LLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQ 516
Query: 165 GQQRQAQLVQRLQGK-------ILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLES 217
+ + ++ +L+ K L+ K + + E QL+ L+ ++QDLE+
Sbjct: 517 LRTEKEEMELKLKEKNDLDEFEALERKTK-KDQEMQLIHEISNLKNLVKHAEVYNQDLEN 575
Query: 218 ALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAA 277
L E +LRE+ DQ + + D +K+ N LE E
Sbjct: 576 ELSSKVE-------------LLREKEDQIKKLQEYI--DSQKLENIKMDLSYSLESIEDP 620
Query: 278 WRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQE 337
+ ++ F+A + L ++ F R SE +L + ELA T + ++
Sbjct: 621 KQMKQTLFDA------ETVALDAKRESAFLR--SE-----NLELKEKMKELATTYKQMEN 667
Query: 338 AGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDL-DKADLS 396
++L +S+ EA + Q L+ +L+ + + + L ++ DL +L
Sbjct: 668 -------DIQLYQSQLEAKKKMQVDLEKELQSAFNE-ITKLTSLIDGKVPKDLLCNLELE 719
Query: 397 ARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEAL--ESLRLQEQAALETEDGEGLQQTLR 454
++T+L + ++NK++ E EAL E + L E +L +E E L++ ++
Sbjct: 720 GKITDL-------------QKELNKEVEEN-EALREEVILLSELKSLPSEV-ERLRKEIQ 764
Query: 455 DLAQAV-LSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSP 513
D ++ + + SE S G L + + +S+ +
Sbjct: 765 DKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSN-------YKSTDQ 817
Query: 514 ACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQL--- 570
+ TL + +K L+ + +Q+++ L K+ +S AL+ +L
Sbjct: 818 EFQNFKTLHMDFEQKYKMVLEENE-----RMNQEIVN-LSKEAQKFDSSLGALKTELSYK 871
Query: 571 -QRLRDKT---DGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQER 626
Q L++KT + E + +++ S + + REK+ + LQ ++ + L QE+
Sbjct: 872 TQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEK 931
Query: 627 EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVR 686
+ L+ QE L+ +RD+L+ + D V + +L + LE L+ + + ++
Sbjct: 932 DDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNA---LESLKQHQETINTLKSKIS 988
Query: 687 EALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNE 746
E +SR + K E + + + + +LE T+ + + + + +
Sbjct: 989 EEVSRNLHMEENTGETKDEFQQKMVGIDK-KQDLEAKNTQTLTADVKDNEIIEQQRKI-F 1046
Query: 747 SLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERL--EELRLEQEVARQ-- 802
SL Q+K +L +++ + EK L+ ++ E T+ +E+ RL +EL+ +QE+ Q
Sbjct: 1047 SLIQEKNELQQMLESVIAEKEQLKTDLKE-NIEMTIENQEELRLLGDELKKQQEIVAQEK 1105
Query: 803 ----GLEGSL-----RVAEQAQEALEQQLPTLRHERSQL---QEQLAQLSRQLSGREQEL 850
EG L R+AE +E L+++ L+ ++ QL QE+++++ ++++ E+
Sbjct: 1106 NHAIKKEGELSRTCDRLAE-VEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKIN----EI 1160
Query: 851 EQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALE 910
E + E + + LE E+ LA++ ++ + +E + L E E++ L
Sbjct: 1161 ENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLR 1220
Query: 911 GSLFEVQRQLAQLEARREQLEAEGQALLLAKET---LTGELAGLRQQIIATQEKASLDKE 967
G + E++ Q +E+L+ L +ET L ++ QII TQ+ L+K
Sbjct: 1221 GYIREIEATGLQ---TKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQD---LEK- 1273
Query: 968 LMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAA-WRELEAERAQLQSQLQREQEE 1026
+ L+E+ E+ + L KE + +E E L Q +
Sbjct: 1274 ------------SHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDST 1321
Query: 1027 LLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLA 1086
LAR+E E+ L+E+ QE E + E+ ++KE+ + + R +LA
Sbjct: 1322 TLARIEMERLRLNEKF----QESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLA 1377
Query: 1087 TISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLG 1146
I +Q++ +++ + +T + SE+ + ++ A E+ L ++ ++
Sbjct: 1378 KIQESQSKQEQSLNMKEKDNETT--KIVSEMEQFK-PKDSALLRIEIEMLGLSKRLQESH 1434
Query: 1147 KQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREV-------QRQEAG 1199
+ S +E ++L+ +L+ D L+ + E K E++E +V Q +
Sbjct: 1435 DEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETIN 1494
Query: 1200 ELRRSLGEGAKE----REALRRSNEELRSAVKK--AESERISLKLANE--DKEQKLALLE 1251
ELR +L E E ++ L N++L++ +++ + E+ ++K +E +K +L +
Sbjct: 1495 ELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFK 1554
Query: 1252 EARTAVGKEAGELRTGLQEVERSRLEARRELQ-------ELRRQMKMLDSENTRLGRELA 1304
E R A + + + E+ E++ E+Q E++R + L E +L
Sbjct: 1555 EHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTK 1614
Query: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER 1364
E+ ++ E EKE + + + +E ++++ + + L+ E E +
Sbjct: 1615 EIVAKMK--ESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQ 1672
Query: 1365 RLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEV 1424
L +LEE R K++ D R +E E + E +L L R + EL V +
Sbjct: 1673 ILHENLEEMRSVTKER-DDLRSVE---ETLKVERDQLKENLRETITRDLEKQEELKIVHM 1728
Query: 1425 QRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSP 1484
+ + + LR + +E + E N LE S
Sbjct: 1729 HLKEHQETIDKLRGIV--------------------------SEKTNEISNMQKDLEHSN 1762
Query: 1485 GSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEA 1544
+ + DL ++ LR L+ Q D+LR S +L+ M+
Sbjct: 1763 DAL----------KAQDL---KIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQK 1809
Query: 1545 ERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQV-- 1602
+ +++ ++ ++ + + +E ++ ++ Q +++ + E +++ +++ TL ++
Sbjct: 1810 DLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVS-EMEQLKKQIKDQSLTLSKLEI 1868
Query: 1603 --ATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQ--- 1657
L + L E+++ ++ ++ E L+ ++ +LKE L +++R ++++ +
Sbjct: 1869 ENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKT 1928
Query: 1658 RRSLEGE----LQRSRLGLSDREAQAQALQDRV----DSLQRQVADSEVKAGTLQLTVER 1709
R L E + + R +S++ Q +Q + D LQ+++ + + K L E
Sbjct: 1929 ARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKED 1988
Query: 1710 LNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKAL-TACEHDRQVLQE 1768
+N + K+ E E L + + S+ S R N L K L + E R V +E
Sbjct: 1989 VNMSHKKINEME--------QLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKE 2040
Query: 1769 RLDAARQALSEARKQSSSLGEQVQTLRGEVA-DLELQRVEAEGQL-----QQLREVLRQR 1822
R + R + E+ K + + TLR +A D + +V+ E +L Q L E LR++
Sbjct: 2041 RDELRR--IKESLKMERD--QFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREK 2096
Query: 1823 QEGEAAALNTVQKLQDERRLLQERLGSLQRAL 1854
L ++ D L L++ +
Sbjct: 2097 CSRIKELLKRYSEMDDHYECLNRLSLDLEKEI 2128
Score = 179 bits (454), Expect = 2e-44
Identities = 392/1941 (20%), Positives = 796/1941 (41%), Gaps = 286/1941 (14%)
Query: 139 RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQ--QLLE 196
++ ++L++QL+E S + QA ++ Q L Q L+ K L K + ++E ++L
Sbjct: 350 KEIMDLKKQLEE--VSLETRAQAMEKDQ-----LAQLLEEKDLLQKVQNEKIENLTRMLV 402
Query: 197 RSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNA--------------MLREQ 242
S L Q+ + + + L ++ + + S Q N +LRE
Sbjct: 403 TSSSLTLQQELKAKRKRRVTWCLGKINK-MKNSNYADQFNIPTNITTKTHKLSINLLREI 461
Query: 243 LDQAGSANQALSEDIRKVTN-DWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWR 301
+ S + S + ++ +W K L E S A + N L+L
Sbjct: 462 DESVCSESDVFSNTLDTLSEIEWNPATKLLNQENI--ESELNSLRADYDN-----LVLDY 514
Query: 302 QVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQA 361
+ + + E+K+ + DL + L R ++ QE L + E L K A
Sbjct: 515 EQLRTEKEEMELKLKEKNDLDEFEA-LERKTKKDQEMQL-------IHEISNLKNLVKHA 566
Query: 362 LLQAQ-LEEQLRDKV--LREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQ 418
+ Q LE +L KV LREK+ +++Q +D L +L +++ +E K
Sbjct: 567 EVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQT 626
Query: 419 VNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTAD 478
+ T L+A +E A L +E+ E L++ +++LA E+ +QL S+
Sbjct: 627 LFDAETVALDAK-----RESAFLRSENLE-LKEKMKELA-TTYKQMENDIQLYQSQ---- 675
Query: 479 ASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTL-ALIHSALHKRQLQVQD 537
L + S A ++ + L +LI + K L +
Sbjct: 676 -----LEAKKKMQVDLEKELQS-------------AFNEITKLTSLIDGKVPKDLLCNLE 717
Query: 538 MRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSA 597
+ G+ + L+K+L+ E AL E++ L E++ L S
Sbjct: 718 LEGK-------ITDLQKELNKEVEENEALREEVILLS---------------ELKSLPSE 755
Query: 598 NELLSREKSNLAHSLQVAQQQAEELRQE----REKLQAAQEELRRQRDRLEEEQEDAVQD 653
E L +E + + L + + ++L E ++Q EE+ + +D L Q +
Sbjct: 756 VERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKST 815
Query: 654 GARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKA 713
+ + H EQ K ++E E +++ + +A+K + +
Sbjct: 816 DQEFQN-FKTLHMDFEQKY-------KMVLEENERMNQEIVNLSK-EAQKFD-----SSL 861
Query: 714 EAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQ 773
A + EL +L+ + +Q+ L+++ L E L L + E EK+ + +
Sbjct: 862 GALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTV----EREKTLITEKL 917
Query: 774 RQAEQEATVAREEQERL----EELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHER 829
+Q +E +E++ L E L++E++ + + ++ + QE L L +L+ +
Sbjct: 918 QQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQ 977
Query: 830 SQLQEQLAQLSRQLSGR---EQELEQARREAQRQVEALERAAREKEALAKEHAGLAV--- 883
+ +++S ++S E+ + + E Q+++ +++ +++ AK L
Sbjct: 978 ETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDK---KQDLEAKNTQTLTADVK 1034
Query: 884 --QLVAAEREGRTLSEEATRLR-------LEKEALEGSL-------FEVQRQLAQLE--- 924
+++ +R+ +L +E L+ EKE L+ L E Q +L L
Sbjct: 1035 DNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDEL 1094
Query: 925 ARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASL 984
+++++ A+ + + KE GEL+ ++ +EK + + +K Q +
Sbjct: 1095 KKQQEIVAQEKNHAIKKE---GELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMS 1151
Query: 985 REQRAAHE-EDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIA 1043
Q+ +E E+L+ + KE +E ER +L +L EE+ + + E++ L E
Sbjct: 1152 EMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKS-ITKERKVLKELQK 1210
Query: 1044 ALQQERDE-----------GLLLAESEKQQALSLKESEKT------ALSEKLMGTRHSLA 1086
+ + ERD GL E K + LKE ++T ++SEK T +
Sbjct: 1211 SFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEK---TAQIIN 1267
Query: 1087 TISLEMERQKRDAQS---RQEQD-----------RSTVNALTSELRDLRAQREEAAAAHA 1132
T LE K + +EQ+ + T+N L + A
Sbjct: 1268 TQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIE 1327
Query: 1133 QEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGRE 1192
E RL E+ ++ ++ S +E + L+T LE D L+ + E K++ESQ +E
Sbjct: 1328 MERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE 1387
Query: 1193 VQ---RQEAGELRRSLGEGAKER---EALRRSNEELRSAVKKAESERISLKLANEDKEQK 1246
+++ E + + E + + AL R E+ K+ + +K ++K+
Sbjct: 1388 QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDD- 1446
Query: 1247 LALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAEL 1306
L+ + + E+ +L+ ++E+ LE EL+ +K + E T + EL
Sbjct: 1447 ---LQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLK--EQEET-----INEL 1496
Query: 1307 QGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRL 1366
+ L+ EKE+ T+ + LE + +LQ +++ E+E +F ++
Sbjct: 1497 RVNLS-----EKETEISTI---------QKQLEAINDKLQNKIQEIYEKEEQFNIKQ--- 1539
Query: 1367 LGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQR 1426
+ ++E KQ +H + + L++ ++ EL RL ++ Q + E ++ +
Sbjct: 1540 ISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQ 1599
Query: 1427 RAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGS 1486
A + + L+ + + + A + E E + E +
Sbjct: 1600 EALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLN 1659
Query: 1487 QPPSPGPATSPASPDLDPEAVR--GALREFLQELRSAQRERDELRTQTSALNRQLAEMEA 1544
+++ E +R L E L+E+RS +ERD+LR+ L +
Sbjct: 1660 LE------------NIETENIRLTQILHENLEEMRSVTKERDDLRSVEETL-------KV 1700
Query: 1545 ERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVAT 1604
ERD R+ E +E L V L +E++ + ++++
Sbjct: 1701 ERDQLKENLRETITRDLEKQE-------ELKIVHMHLKEHQETIDKLRGIVSEKTNEISN 1753
Query: 1605 LERSLQATESELRASQEKI-SKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLE- 1662
+++ L+ + L+A KI +++ L+ + + ++ +T KL ++ LE
Sbjct: 1754 MQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLEN 1813
Query: 1663 --GELQRSRLGLSDREAQAQALQDRVDSLQRQVADSE-----VKAGTL---QLTVERLNG 1712
+LQ L E Q L+ V+ Q++V++ E +K +L +L +E LN
Sbjct: 1814 SNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNL 1873
Query: 1713 AL---AKVEESEGAL--RDKVRGLTEALA----QSSASLNSTRDKNLHLQKALTACEHDR 1763
A +EE + + RD +R + E L Q SL T+ ++L +Q+ L
Sbjct: 1874 AQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLS 1933
Query: 1764 QVLQERLDAARQALSEARKQSSSLGEQVQTLRGEV---------ADLELQRVEAEGQL-- 1812
+ +E +D R+ +SE Q S + + + + E+ +L+L RV+ + +
Sbjct: 1934 KEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSH 1993
Query: 1813 QQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQ--RALAQLEAEKREVERSALR 1870
+++ E+ + +++ EA L+ D +L ++ SL+ R +A+ E R ++ S L+
Sbjct: 1994 KKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKES-LK 2052
Query: 1871 LEKDR-VALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEA 1929
+E+D+ +A R + +R+ + + LS + L +L + E ++ +++
Sbjct: 2053 MERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDD 2112
Query: 1930 QVVVLEQSHSPAQLEVDAQQQ 1950
L + + E++ Q++
Sbjct: 2113 HYECLNRLSLDLEKEIEFQKE 2133
Score = 169 bits (428), Expect = 3e-41
Identities = 306/1562 (19%), Positives = 664/1562 (42%), Gaps = 161/1562 (10%)
Query: 528 LHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDA 587
L +++ Q++ ++ ++ + L ++ LS S ++ Q L D A+ DA
Sbjct: 584 LREKEDQIKKLQEYIDSQK--LENIKMDLSYSLESIEDPKQMKQTLFDAETVAL----DA 637
Query: 588 QREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQ 647
+RE LRS N L + LA + + + + + + E + Q +L ++ L+
Sbjct: 638 KRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKE---LQSAF 694
Query: 648 EDAVQDGARVRRELERSHRQLEQLEGKRSVLAKEL---VEVREALSRATLQRDMLQAEKA 704
+ + + + ++ + +LEGK + L KEL VE EAL + L++ +
Sbjct: 695 NEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPS 754
Query: 705 EVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEE 764
EV + + EL + ++ + + S++ L E + + K DL + +
Sbjct: 755 EVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKS 814
Query: 765 EKSALQGRQR---QAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQ 821
Q + EQ+ + EE ER+ QE+ + ++++AQ+ +
Sbjct: 815 TDQEFQNFKTLHMDFEQKYKMVLEENERMN-----QEI--------VNLSKEAQK-FDSS 860
Query: 822 LPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGL 881
L L+ E S ++L + +R++ R E+EQ + + + + L+ REK + ++
Sbjct: 861 LGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQT 920
Query: 882 AVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAK 941
++ +E L + L++E++ L+ + + + EQL ++L +
Sbjct: 921 LEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQ---EQLRNALESLKQHQ 977
Query: 942 ETLTGELAGLRQQI---IATQEKASLDKELMAQKLVQAER--EAQASLREQRAAHEEDLQ 996
ET+ + + +++ + +E K+ QK+V ++ + +A + A +D +
Sbjct: 978 ETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNE 1037
Query: 997 RLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLA 1056
++++++ Q +++LQ+ E ++A E K +L E I + ++E LL
Sbjct: 1038 IIEQQRKIF------SLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLG 1091
Query: 1057 -ESEKQQALSLKESEKTALSE-KLMGTRHSLATISLEMERQKRDAQSRQEQ------DRS 1108
E +KQQ + +E E +L T LA + +++ + + Q +Q+Q + S
Sbjct: 1092 DELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMS 1151
Query: 1109 TVNALTSELRDLRAQ--REEAAAAHAQEVR-RLQEQARDLGKQRDSCLREAEELRTQLRL 1165
+ +E+ +L+ + +E H + R L ++ + ++ S +E + L+ +
Sbjct: 1152 EMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKS 1211
Query: 1166 LEDARDGLR---REL----LEAQRKLRESQEGREVQRQEAGELRRSLGEGAKE---REAL 1215
E RD LR RE+ L+ + +L+ + + ++ ELRRS+ E + + L
Sbjct: 1212 FETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDL 1271
Query: 1216 RRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSR 1275
+S+ +L+ + E+ L E E + + E + + T L +E R
Sbjct: 1272 EKSHTKLQEEIPVLHEEQELLPNVKEVSETQ-ETMNELELLTEQSTTKDSTTLARIEMER 1330
Query: 1276 LEARRELQELRRQMKMLDSE--NTRLGRELAELQG-------RLALGERAEKESRRE-TL 1325
L + QE + ++K L E N + +E E++ R L + E +S++E +L
Sbjct: 1331 LRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSL 1390
Query: 1326 GLRQRLLKGEASLEVMRQ-------------ELQVAQRKLQEQEGEFRT--RERRLLGSL 1370
++++ + + M Q E+ ++LQE E ++ +E+ L L
Sbjct: 1391 NMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRL 1450
Query: 1371 EEARGTEKQQLDH------ARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEV 1424
+E +E QL A+ LE + E A L E L L+ E
Sbjct: 1451 QEVLQSESDQLKENIKEIVAKHLETEEELKVAHCC-----LKEQEETINELRVNLSEKET 1505
Query: 1425 QRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSP 1484
+ + QL + L+ + E N E
Sbjct: 1506 EISTIQKQLEAINDKLQNKI--------------------QEIYEKEEQFNIKQISEVQE 1545
Query: 1485 GSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEA 1544
A D +++ + E L+ +Q E + + + R ++
Sbjct: 1546 KVNELKQFKEHRKAK-DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQI 1604
Query: 1545 ERDSATSRARQLQKAVAESEEAR-RSVDGRLSGVQAELALQEESVRRSERERRATLDQVA 1603
ERD +++ + ES+E + + E + E ++ ++ L+ +
Sbjct: 1605 ERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIE 1664
Query: 1604 T----LERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRR 1659
T L + L E+R+ ++ +++ E L+ ++ +LKE L + +R ++ + + +
Sbjct: 1665 TENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELK 1724
Query: 1660 SLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSE--VKAGTLQLTVERLNGALAKV 1717
+ L+ + + + + ++Q+ + S +KA L++ E L A +
Sbjct: 1725 IVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ-EELRIAHMHL 1783
Query: 1718 EESEGALRDKVRGL----TEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAA 1773
+E + + DK+RG+ T+ L+ L ++ K + L A EH L++ ++
Sbjct: 1784 KEQQETI-DKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNET 1842
Query: 1774 RQALSEARKQSSSLGEQVQTL-RGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNT 1832
++ +SE + + +Q TL + E+ +L L + + L++++ V+++R +
Sbjct: 1843 QKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQ-KLHENLEEMKSVMKER--------DN 1893
Query: 1833 VQKLQDERRLLQERL-GSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLR 1891
++++++ +L +++L SLQ A+ + E ++ ++A L K+ + T+DK+ REK+
Sbjct: 1894 LRRVEETLKLERDQLKESLQETKAR-DLEIQQELKTARMLSKEH---KETVDKL-REKI- 1947
Query: 1892 SHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQ 1951
E T+++S + LD++ + ++ E Q++ QL + SH E++ ++Q
Sbjct: 1948 -SEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKIN-EMEQLKKQ 2005
Query: 1952 LELQQ-EVERLRSAQAQ-TERTLEARER-----AHRQRVRGLEEQVSTLKGQLQQELRRS 2004
E Q ++ +R Q T++ E+ E R +R ++E + + Q LR
Sbjct: 2006 FEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREM 2065
Query: 2005 SA 2006
A
Sbjct: 2066 IA 2067
Score = 166 bits (421), Expect = 2e-40
Identities = 389/2103 (18%), Positives = 821/2103 (39%), Gaps = 297/2103 (14%)
Query: 50 LIREIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAI 109
L+REI S ES V + S + +LL QE +E L RA+ D L +
Sbjct: 457 LLREIDESVCS--ESDVFSNTLDTLSEIEWNPATKLLNQE--NIESELNSLRADYDNLVL 512
Query: 110 KYNAV-SERLEQALRLEP----GELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQE 164
Y + +E+ E L+L+ E E E + Q ++L ++ + + Q+
Sbjct: 513 DYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQD 572
Query: 165 GQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLE- 223
+ + V+ L+ K Q KK ++ Q LE L E + ++ L E
Sbjct: 573 LENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAET 632
Query: 224 ---EEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRK---ELEHREAA 277
+ ++ SA L N L+E++ + + + + DI+ + +K +LE +
Sbjct: 633 VALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQS 692
Query: 278 WRREEESFNAYFSNEHSRLLLLWRQVVG--------FRRLVSEVKMFTER-----DLLQL 324
E + + + LL ++ G + V E + E +L L
Sbjct: 693 AFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSL 752
Query: 325 GGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQ 384
E+ R + +Q+ L + + K++ +Q LEE + K DLA
Sbjct: 753 PSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTK----DDLATT 808
Query: 385 QMQ---SDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL--RLQEQA 439
Q +D + + + K + ++N +Q +L+++ + +S L+ +
Sbjct: 809 QSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTEL 868
Query: 440 ALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSG--QRTPSPPR 497
+ +T++ LQ+ R++ + + + QL + T ++ Q+T +
Sbjct: 869 SYKTQE---LQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVK 925
Query: 498 RSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEA---SQDLLGTLRK 554
+ + + S + IH ++ + +R E+ Q+ + TL+
Sbjct: 926 TLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKS 985
Query: 555 QLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQ----REVQRLRSA---NELLSREKS- 606
++S+ S +EE +D+ M + Q + Q L + NE++ +++
Sbjct: 986 KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKI 1045
Query: 607 -NLAHSLQVAQQQAEELRQEREKLQAA-----------QEELRRQRDRLEEEQEDAVQDG 654
+L QQ E + E+E+L+ QEELR D L+++QE Q
Sbjct: 1046 FSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQ-- 1103
Query: 655 ARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE 714
E++H + EG+ S L EV E L + Q Q + V E +++ +
Sbjct: 1104 -------EKNHAIKK--EGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQ 1154
Query: 715 AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQR 774
E+E +L+ +E +L+ +E E+ L +
Sbjct: 1155 KKINEIENLKNELKNKELTLE-------------------------HMETERLELAQKLN 1189
Query: 775 QAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQE 834
+ +E +E++ L+EL+ E R L G +R E +++L + QE
Sbjct: 1190 ENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQE 1249
Query: 835 QLAQLSRQLSGRE------QELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAA 888
+ +L R +S + Q+LE++ + Q ++ L E+E L Q
Sbjct: 1250 TIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHE---EQELLPNVKEVSETQETMN 1306
Query: 889 EREGRTLSEEAT--------RLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLA 940
E E L+E++T R+ +E+ L E Q ++ L R+ L+ +AL +
Sbjct: 1307 ELE--LLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVK 1364
Query: 941 KETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQR 1000
+ L + R+ + QE S ++ + K E S EQ + L R++
Sbjct: 1365 HDQLKEHI---RETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEI 1421
Query: 1001 EKEAAWRELEAERAQLQS------QLQREQEELLARLEAEKEELSEEIAALQQERDEGLL 1054
E + L+ +++S LQR QE L + + KE + +EI A E +E L
Sbjct: 1422 EMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENI-KEIVAKHLETEEELK 1480
Query: 1055 LAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALT 1114
+A LKE E+T + + + + ++ + + Q+Q + + L
Sbjct: 1481 VAHC------CLKEQEET------------INELRVNLSEKETEISTIQKQLEAINDKLQ 1522
Query: 1115 SELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLR 1174
++++++ + E+ + +++ +QE+ +L ++ + + + A +
Sbjct: 1523 NKIQEIYEKEEQF---NIKQISEVQEKVNEL-----------KQFKEHRKAKDSALQSIE 1568
Query: 1175 RELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKA-ESER 1233
++LE +L+ESQE ++ +E E++R ER+ L+ + +E+ + +K++ E E
Sbjct: 1569 SKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEY 1628
Query: 1234 ISLKL-ANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKML 1292
LK+ A + ++K+ +E + + + L+ +E + + L E +M+ +
Sbjct: 1629 QFLKMTAVNETQEKMCEIEHLKEQFETQ----KLNLENIETENIRLTQILHENLEEMRSV 1684
Query: 1293 DSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKL 1352
E +L ++ L + KE+ RET+ R L+ + L+++ L+ Q +
Sbjct: 1685 TKERD----DLRSVEETLKVERDQLKENLRETI---TRDLEKQEELKIVHMHLKEHQETI 1737
Query: 1353 Q-------EQEGEFRTRERRLLGSLEEARGTEKQQLD-------HARGLELKLEAARAEA 1398
E+ E ++ L S + + + + + H + + ++ R
Sbjct: 1738 DKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIV 1797
Query: 1399 AELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVP 1458
+E +LS + + A+L + +A E QL L+ + V
Sbjct: 1798 SEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLK-----------------KDVN 1840
Query: 1459 GSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQEL 1518
+ + + E + + S + + +++ + L E L+E+
Sbjct: 1841 ETQKKVSEMEQLKKQIKDQSL----------------TLSKLEIENLNLAQKLHENLEEM 1884
Query: 1519 RSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAE----SEEARRSVD--- 1571
+S +ERD LR L + +++ +R ++Q+ + S+E + +VD
Sbjct: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLR 1944
Query: 1572 GRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANET 1631
++S +++ ++ + +S+ E + + ++ E L + ++ S +KI++M+ +
Sbjct: 1945 EKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKK 2004
Query: 1632 KLEGDKRRLKEVLDASESRTVKL---------------ELQRRSLEGELQRSRLGLSDRE 1676
+ E ++ V + T KL EL+R +++R + + RE
Sbjct: 2005 QFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLRE 2064
Query: 1677 AQAQALQD-RVDSLQRQVADSEVK-AGTLQLTVERLNGALAKVEESEG----------AL 1724
A+ Q+ +V +R ++D + +L+ R+ L + E + L
Sbjct: 2065 MIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDL 2124
Query: 1725 RDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQS 1784
++ E + A+L+ + H++K TA + + + LS K
Sbjct: 2125 EKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIK 2184
Query: 1785 SSLGEQVQTLRGEVAD---------LELQRVEAE-----GQLQQLR----------EVLR 1820
E + + D +++Q ++ + +L+ L+ E+L+
Sbjct: 2185 EEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILK 2244
Query: 1821 QRQEGEAAALNT-VQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALR 1879
E E ++ T Q++ R+ + + L +E K +++ R+ +
Sbjct: 2245 DFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFN 2304
Query: 1880 RTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQS-H 1938
+ + E E + +S E E +L + + ++L L+ S
Sbjct: 2305 NRIIAIMNESTEFEERSATISKE----------WEQDLKSLKEKNEKLFKNYQTLKTSLA 2354
Query: 1939 SPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQ 1998
S AQ+ Q + R+ Q TE+ E H + + ++ +K Q +
Sbjct: 2355 SGAQVNPTTQDN----KNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKE 2410
Query: 1999 QEL 2001
E+
Sbjct: 2411 LEV 2413
Score = 144 bits (363), Expect = 9e-34
Identities = 323/1575 (20%), Positives = 630/1575 (40%), Gaps = 296/1575 (18%)
Query: 656 RVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEA 715
R R+E+ +QLE++ + A E ++ L++ ++D+LQ + E E LT+
Sbjct: 347 RYRKEIMDLKKQLEEVSLETRAQAME----KDQLAQLLEEKDLLQKVQNEKIENLTRMLV 402
Query: 716 GRVELELSMTKLRAEEASLQDSLSKLSALNESLAQD-------------KLDLNRL---- 758
L L + + L K++ + S D KL +N L
Sbjct: 403 TSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREID 462
Query: 759 ----------------VAQLEEEKSALQGRQRQAEQEATVAREEQERL----EELRLEQE 798
++++E + Q E E R + + L E+LR E+E
Sbjct: 463 ESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKE 522
Query: 799 VARQGLEGSLRVAEQAQ----EALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR 854
E L++ E+ EALE++ T + + QL +++ L + E +
Sbjct: 523 ------EMELKLKEKNDLDEFEALERK--TKKDQEMQLIHEISNLKNLVKHAEVYNQDLE 574
Query: 855 REAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLE--KEALEGS 912
E +VE L REKE K+ L E +LE K L S
Sbjct: 575 NELSSKVELL----REKEDQIKK-----------------LQEYIDSQKLENIKMDLSYS 613
Query: 913 LFEVQ--RQLAQ--LEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKEL 968
L ++ +Q+ Q +A L+A+ ++ L E L EL +++ T ++ D +L
Sbjct: 614 LESIEDPKQMKQTLFDAETVALDAKRESAFLRSENL--ELKEKMKELATTYKQMENDIQL 671
Query: 969 MAQKLVQAEREAQASLREQRAAHEEDLQRL------QREKEAAWR-ELEAERAQLQSQLQ 1021
Q ++A+++ Q L ++ + ++ +L + K+ ELE + LQ +L
Sbjct: 672 Y-QSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELN 730
Query: 1022 REQEELLARLE-----AEKEELSEEIAALQ---QERDEGLLLAESEKQQALS---LKESE 1070
+E EE A E +E + L E+ L+ Q++ E L + SEK + S KES
Sbjct: 731 KEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESR 790
Query: 1071 KTALSEKLMGTRHSLATI---------------SLEMERQKRDAQSRQEQDR-------- 1107
L E++ T+ LAT +L M+ +++ +E +R
Sbjct: 791 VQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNL 850
Query: 1108 --------STVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEEL 1159
S++ AL +EL + Q + QE EQ ++ + RDS L+ E
Sbjct: 851 SKEAQKFDSSLGALKTEL-SYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVERE 909
Query: 1160 RTQL-----RLLEDARDGLRRELLEAQRKLRESQEGREVQR-QEAGELRRSLGEGAKERE 1213
+T + + LE+ + L + + L++ QE +++R Q ++ ++ +E
Sbjct: 910 KTLITEKLQQTLEEV-----KTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQE 964
Query: 1214 ALRRSNEELR------SAVKKAESERISLKLANEDK--------EQKLALLEEARTAVGK 1259
LR + E L+ + +K SE +S L E+ +QK+ +++ + K
Sbjct: 965 QLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAK 1024
Query: 1260 EAGELRTGLQ-----EVERSRLEARRELQELRRQMKMLDSENTRLGREL-------AELQ 1307
L ++ E +R +E EL++ ++ + +E +L +L E Q
Sbjct: 1025 NTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQ 1084
Query: 1308 GRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLL 1367
L L K+ + + +K E L L + KL+E+ + + ++++LL
Sbjct: 1085 EELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLL 1144
Query: 1368 GSLEEARGTEKQ------QLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELAR 1421
EE +K+ + + EL LE E EL +L+ + + E
Sbjct: 1145 NVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKV 1204
Query: 1422 VEVQRRAAEAQLGGLRSALRRGLGLGRAPSP---------APRPVPGSPARDAPAEGSGE 1472
++ +++ E + LR +R G R + +E + +
Sbjct: 1205 LKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQ 1264
Query: 1473 GLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVR-GALREFLQELRSAQRERDELRTQ 1531
+N+ + Q P +L P +E + EL + +
Sbjct: 1265 IINTQDLEKSHTKLQEEIP---VLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDST 1321
Query: 1532 TSA--------LNRQLAEMEAERDSATSRARQLQKAVAES-----EEARRSVDGRLSGVQ 1578
T A LN + E + E S T + R K + E+ ++ + + L+ +Q
Sbjct: 1322 TLARIEMERLRLNEKFQESQEEIKSLT-KERDNLKTIKEALEVKHDQLKEHIRETLAKIQ 1380
Query: 1579 AELALQEESVRRSERERRAT-----LDQVATLERSLQATESEL----RASQEKISKMKAN 1629
+ QE+S+ E++ T ++Q + +L E E+ + QE +MK +
Sbjct: 1381 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMK-S 1439
Query: 1630 ETKLEGDKRRLKEVLDASESRTVK---LELQRRSLEGE----------------LQRSRL 1670
K + D +RL+EVL SES +K E+ + LE E + R+
Sbjct: 1440 VAKEKDDLQRLQEVLQ-SESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRV 1498
Query: 1671 GLSDREAQAQALQDRVDSLQRQVAD--SEVKAGTLQLTVERLNGALAKVEESEGALRDKV 1728
LS++E + +Q +++++ ++ + E+ Q +++++ KV E +
Sbjct: 1499 NLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNE--------L 1550
Query: 1729 RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVL---QERLDAARQALSEARKQSS 1785
+ E ++L S K L L L + + Q++ +E + ++AL R Q
Sbjct: 1551 KQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLK 1610
Query: 1786 SLGEQVQTLRGEVADLELQ--RVEAEGQLQQ-LREVLRQRQEGEAAALNTVQKLQDER-- 1840
+++ E + E Q ++ A + Q+ + E+ +++ E LN ++ ++ E
Sbjct: 1611 ENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLN-LENIETENIR 1669
Query: 1841 --RLLQERLGSLQRALAQLEAEKREVERSALRLEKD------RVALRRTLDKVEREK--- 1889
++L E L + R++ + + R VE + L++E+D R + R L+K E K
Sbjct: 1670 LTQILHENLEEM-RSVTKERDDLRSVEET-LKVERDQLKENLRETITRDLEKQEELKIVH 1727
Query: 1890 --LRSHEDTV--------------------------RLSAEKGRLDRTLTGAELELAEAQ 1921
L+ H++T+ L A+ ++ L A + L E Q
Sbjct: 1728 MHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQ 1787
Query: 1922 RQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQ 1981
I +L +V E++ + ++ D + +LQ++++ L++ + Q TL+ ++
Sbjct: 1788 ETIDKLRG--IVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQL-ITLKKDVNETQK 1844
Query: 1982 RVRGLEEQVSTLKGQ 1996
+V +E+ +K Q
Sbjct: 1845 KVSEMEQLKKQIKDQ 1859
Score = 93.6 bits (231), Expect = 2e-18
Identities = 234/1321 (17%), Positives = 518/1321 (39%), Gaps = 161/1321 (12%)
Query: 72 EMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELET 131
EM S+ +++ Q LQ+ L D L ++ E V++ LE L+
Sbjct: 1436 EMKSVAKEKDDLQRLQEVLQSESDQLKENIKE---------IVAKHLETEEELKVAHCCL 1486
Query: 132 QEPRGLVRQSVELRRQLQEEQ---ASYRRKLQAYQEGQQRQAQLVQRLQGKILQYK-KRC 187
+E + ELR L E++ ++ +++L+A + Q + +Q + K Q+ K+
Sbjct: 1487 KEQEETIN---ELRVNLSEKETEISTIQKQLEAINDKLQNK---IQEIYEKEEQFNIKQI 1540
Query: 188 SELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAG 247
SE+++++ E E ++ +D+ Q +ES ++ L Q S Q+ +E++ +
Sbjct: 1541 SEVQEKVNELKQFKEHRKAKDSA-LQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQ 1599
Query: 248 SANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFR 307
A Q + +++ T + KE + +E + + NE +
Sbjct: 1600 EALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAV------NETQEKMCE-------- 1645
Query: 308 RLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALL--QA 365
+ +K E L L R Q L + + R + ++ L +
Sbjct: 1646 --IEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERD 1703
Query: 366 QLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTE 425
QL+E LR+ + R+ + ++ + + + +L V EK N E + KDL
Sbjct: 1704 QLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVS--EKTN-EISNMQKDLEH 1760
Query: 426 KLEALES--LRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGS 483
+AL++ L++QE+ + + Q+T+ L V SE +LS ++ + SN
Sbjct: 1761 SNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIV---SEKTDKLSNMQKDLENSNAK 1817
Query: 484 LRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYE 543
L+ + ++ L + +++ Q +V +M
Sbjct: 1818 LQEKIQELK-----------------------ANEHQLITLKKDVNETQKKVSEME---- 1850
Query: 544 ASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSR 603
L+KQ+ D LE + L K ++ + +E LR E L
Sbjct: 1851 -------QLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKL 1903
Query: 604 EKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELER 663
E+ L SLQ + + E++QE + + +E + D+L E+ + + ++++L++
Sbjct: 1904 ERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDK 1963
Query: 664 SHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELS 723
S +L++ + +L+ V+E ++ + +K E L K + LS
Sbjct: 1964 SKDELQKKIQELQKKELQLLRVKEDVN--------MSHKKINEMEQLKKQFEAQ---NLS 2012
Query: 724 MTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVA 783
M +R + L L + +A+++ +L R+ L+ E+ R+ +A
Sbjct: 2013 MQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLRE-----MIA 2067
Query: 784 REEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQL 843
R+ Q +++ E+ + +G + E +E ++ L S++ + L+R
Sbjct: 2068 RDRQN--HQVKPEKRLLS---DGQQHLTESLREKC-SRIKELLKRYSEMDDHYECLNRLS 2121
Query: 844 SGREQELE-----QARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 898
E+E+E R +A + L+ EK A + + + + L
Sbjct: 2122 LDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIM-----KKLKYV 2176
Query: 899 ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIAT 958
+ + KE S+ + + ++++L + Q L + + EL L+
Sbjct: 2177 LSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLK-----L 2231
Query: 959 QEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQS 1018
+ L E + + ++E + + +Q ++ +++ + E W + +L++
Sbjct: 2232 NQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEE----WLNTRFDIEKLKN 2287
Query: 1019 QLQREQEEL----------LARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKE 1068
+Q+E + + + + E E E A + +E ++ L + + ++ +
Sbjct: 2288 GIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQ 2347
Query: 1069 SEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAA 1128
+ KT+L+ ++ +D ++ R+T T ++R+L EA
Sbjct: 2348 TLKTSLAS------------GAQVNPTTQDNKNPHVTSRAT-QLTTEKIRELENSLHEAK 2394
Query: 1129 AAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGL--------------R 1174
+ + ++ + ++L D + ++ + LE ++ + +
Sbjct: 2395 ESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYK 2454
Query: 1175 RELLEAQRKL-RESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESER 1233
E+ + + KL + E + ++ E+ + ++E +R E LR + + ++
Sbjct: 2455 EEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSV 2514
Query: 1234 ISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLD 1293
IS + + L + +A L++ +E+ + +++ ++L +Q L
Sbjct: 2515 ISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELL 2574
Query: 1294 SENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQ 1353
S N L E+ + R L A K+ E + + G AS + Q +R LQ
Sbjct: 2575 SNNQHLSNEVKTWKER-TLKREAHKQVTCEN-SPKSPKVTGTASKKKQITPSQCKERNLQ 2632
Query: 1354 E 1354
+
Sbjct: 2633 D 2633
Score = 34.3 bits (77), Expect = 1.3
Identities = 29/132 (21%), Positives = 67/132 (50%), Gaps = 7/132 (5%)
Query: 1726 DKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSS 1785
+K+R L +L ++ S K + +QK L LQ ++ + + L + ++
Sbjct: 2381 EKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQ 2440
Query: 1786 SLGEQV----QTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERR 1841
L ++V + + E+ DL+++ V+ + L++++ ++ ++ +A TV+ ++ R
Sbjct: 2441 VLQDKVALGAKPYKEEIEDLKMKLVKID--LEKMKNA-KEFEKEISATKATVEYQKEVIR 2497
Query: 1842 LLQERLGSLQRA 1853
LL+E L Q+A
Sbjct: 2498 LLRENLRRSQQA 2509
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 186 bits (472), Expect = 2e-46
Identities = 249/1151 (21%), Positives = 480/1151 (41%), Gaps = 160/1151 (13%)
Query: 386 MQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETED 445
++S + +++ E G + LEK + ++ + + L+ L+LQ QA
Sbjct: 842 LKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAE----- 896
Query: 446 GEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGR 505
Q L D + ++ +QL + + ++ + T
Sbjct: 897 ----QDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELT------------- 939
Query: 506 SPRRGPSPACSDSS--------TLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLS 557
+ +R CS+ TLA + H + +V+++ +++ L K+
Sbjct: 940 AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 999
Query: 558 DSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANEL-------LSREKSNLAH 610
+ + + LQ DK + ++ +++V L + E L R K L
Sbjct: 1000 ALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEG 1059
Query: 611 SLQVAQQQAEELRQER----EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHR 666
L++ Q+ +L ++ EKL+ + ++ +Q ++E+EQ A+Q ++++L+ +
Sbjct: 1060 DLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQ----LQKKLKENQA 1115
Query: 667 QLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTK 726
++E+LE +EL R A ++ R L E E++E L +A G +++ M K
Sbjct: 1116 RIEELE-------EELEAERTARAKVEKLRSDLSRELEEISERLEEA-GGATSVQIEMNK 1167
Query: 727 LRA----------EEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQA 776
R EEA+LQ + +AL + A +L + L+ K L+ + +
Sbjct: 1168 KREAEFQKMRRDLEEATLQHEATA-AALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF 1226
Query: 777 EQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQL 836
+ E E++ + + E + LE E ++ L +R++LQ +
Sbjct: 1227 KLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTEN 1286
Query: 837 AQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLS 896
+L+RQL +E + Q R + +E R+ E K LA L +A + L
Sbjct: 1287 GELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLR 1346
Query: 897 EEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEG-QALLLAKETLTGELAGLRQQI 955
E+ K L+ L + ++AQ + E + + L AK+ L L + +
Sbjct: 1347 EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAV 1406
Query: 956 IATQEK-ASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERA 1014
A K +SL+K + +Q E E E+ A L + QR + E + +
Sbjct: 1407 EAVNAKCSSLEK---TKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE 1463
Query: 1015 QLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTAL 1074
+ QS+L+ Q+E LS E+ L+ +E L E+ K++ +L+E E + L
Sbjct: 1464 ESQSELESSQKEA--------RSLSTELFKLKNAYEESLEHLETFKRENKNLQE-EISDL 1514
Query: 1075 SEKL-MGTR--HSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAH 1131
+E+L G + H L + ++E +K + QS E+ +++ E + LRAQ E
Sbjct: 1515 TEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEH--EEGKILRAQLE-FNQIK 1571
Query: 1132 AQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR 1191
A+ R+L E+ ++ + + + R + L+T L DA R E+L ++K+
Sbjct: 1572 AEIERKLAEKDEEMEQAKRNHQRVVDSLQTSL----DAETRSRNEVLRVKKKMEGDLNEM 1627
Query: 1192 EVQRQEAGELRRSLGEGAKEREALRRSNE-ELRSAVKKAESERISLKLANEDKEQKLALL 1250
E+Q A + + K ++L + + +L AV+ AN+D ++ +A++
Sbjct: 1628 EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVR-----------ANDDLKENIAIV 1676
Query: 1251 EEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRL----------- 1299
E + E ELR +++ ERSR A +EL E ++++L S+NT L
Sbjct: 1677 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDL 1736
Query: 1300 -------------------------------GRELAELQGRLALGERAEKESRRETLGLR 1328
EL + Q A ER +K + L+
Sbjct: 1737 TQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1796
Query: 1329 QRLLKGEA-SLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEK--------- 1378
RL + E +L+ +++LQ + +++E EGE ++R S++ R +E+
Sbjct: 1797 HRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQT 1856
Query: 1379 --------QQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAE 1430
+ D L+LK++A + +A E + + + + ++ EL E + AE
Sbjct: 1857 EEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAE 1916
Query: 1431 AQLGGLRSALR 1441
+Q+ LR+ R
Sbjct: 1917 SQVNKLRAKSR 1927
Score = 173 bits (438), Expect = 2e-42
Identities = 241/1164 (20%), Positives = 477/1164 (40%), Gaps = 129/1164 (11%)
Query: 684 EVREALSRATLQRDM--LQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKL 741
+++ L A +++M ++ E + E L K+EA R ELE M L E+ LQ
Sbjct: 837 KIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQ------ 890
Query: 742 SALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVAR 801
L QD L+ EE L + Q E + E E EE+ E +
Sbjct: 891 --LQVQAEQDNLN------DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKK 942
Query: 802 QGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQV 861
+ LE ++ + LE L + E+ + ++ L+ +++G +
Sbjct: 943 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD-------------- 988
Query: 862 EALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLA 921
E + + +EK+AL + H L E + +LS+ +L + + LEGSL + ++
Sbjct: 989 EIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRM 1048
Query: 922 QLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQ 981
LE + +LE + L L +E++ +L + Q+ +K D K ++ E+
Sbjct: 1049 DLERAKRKLEGD---LKLTQESIM-DLENDKLQLEEKLKKKEFDINQQNSK-IEDEQVLA 1103
Query: 982 ASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEE 1041
L+++ ++ ++ L+ E EA R A+ +L+S L RE EE+ RLE S +
Sbjct: 1104 LQLQKKLKENQARIEELEEELEAE-RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQ 1162
Query: 1042 IAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQS 1101
I + ++R+ + ++A E+ AL +K + L ++R K+ +
Sbjct: 1163 IE-MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEK 1221
Query: 1102 RQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRR-LQEQARDLGKQRDSCLREAEELR 1160
+ + + ++ +TS + + A A+ ++V R L++QA + + + R +
Sbjct: 1222 EKSEFKLELDDVTSNMEQIIK-----AKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFT 1276
Query: 1161 TQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNE 1220
TQ L+ L R+L E + + + G+ Q+ +L+R L E K + AL + +
Sbjct: 1277 TQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQ 1336
Query: 1221 ELR------------SAVKKAESERISLKLANE----------DKEQKLALLEEARTAVG 1258
R KAE +R+ K +E D Q+ LEEA+ +
Sbjct: 1337 SARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1396
Query: 1259 KEAGELRTGLQEV-------ERSRLEARRELQELRRQMKM-------LDSENTRLGRELA 1304
+ + ++ V E+++ + E+++L ++ LD + + LA
Sbjct: 1397 QRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA 1456
Query: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER 1364
E + + + + S++E L L K + + E + L+ +R+ + + E
Sbjct: 1457 EWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEE------ 1510
Query: 1365 RLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEV 1424
+ L E G + + + +LE E EL L AE + E ++ R ++
Sbjct: 1511 --ISDLTEQLGEGGKNVHELEKVRKQLEV---EKLELQSALEEAEASLEHEEGKILRAQL 1565
Query: 1425 QRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPG-SPARDAPAEGSGEGLNSPSTLECS 1483
+ +A++ R + + +A R V + DA E L +E
Sbjct: 1566 EFNQIKAEIE--RKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGD 1623
Query: 1484 PGSQPPSPGPATSPASP-DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEM 1542
A A+ ++++ L++ +L A R D+L+ + + R+ +
Sbjct: 1624 LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLL 1683
Query: 1543 EAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQV 1602
+AE + +L+ V ++E +R+ + L + L +++ +
Sbjct: 1684 QAELE-------ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDL 1736
Query: 1603 ATLERSLQATESELRASQEKISK------MKANETKLEGDKRRLKEVLDASESRTVKLEL 1656
L+ ++ E R ++EK K M A E K E D E + + +T+K +L
Sbjct: 1737 TQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIK-DL 1795
Query: 1657 QRRSLEGE---LQRSRLGLSDREAQAQALQDRVDSLQRQVADS---------EVKAGTLQ 1704
Q R E E L+ + L EA+ + L+ +++ Q++ A+S +K T Q
Sbjct: 1796 QHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQ 1855
Query: 1705 LTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQ 1764
++ N L ++++ L+ KV+ ++ N+ K +Q H+
Sbjct: 1856 TEEDKKN--LLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQ-------HELD 1906
Query: 1765 VLQERLDAARQALSEARKQSSSLG 1788
+ER D A +++ R +S +G
Sbjct: 1907 EAEERADIAESQVNKLRAKSRDIG 1930
Score = 169 bits (428), Expect = 3e-41
Identities = 286/1287 (22%), Positives = 556/1287 (43%), Gaps = 181/1287 (14%)
Query: 74 ASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQE 133
A LL L EE + + LSR+ + Q++A + I++ + ER + L ++
Sbjct: 769 AGLLGLLEE--MRDERLSRIITRM-QAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMG 825
Query: 134 PRGLVRQSVELR-------RQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKR 186
+ + + + ++E A+ + + +E ++ + L+ K++ +
Sbjct: 826 VKNWPWMKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQE 885
Query: 187 CSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQA 246
++L+ Q+ + EQ L D E D ++ + Q A + ++N E+L+
Sbjct: 886 KNDLQLQV-----QAEQDNLNDAEERCDQ-----LIKNKIQLEAKVKEMN----ERLEDE 931
Query: 247 GSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGF 306
N L+ RK+ ++ + +K+++ E + E+ +A +++ L ++ G
Sbjct: 932 EEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA----TENKVKNLTEEMAGL 987
Query: 307 RRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQ 366
+++ +L + +A+QEA L++ E + + + + L+ Q
Sbjct: 988 DEIIA---------------KLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQ 1032
Query: 367 LEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEK 426
+++ L + +EK +++ DL++A R E L + + +LE D++ L EK
Sbjct: 1033 VDD-LEGSLEQEK-----KVRMDLERA---KRKLEGDLKLTQESIMDLENDKL--QLEEK 1081
Query: 427 LEALESLRLQEQAALETEDGEGLQ-QTLRDLAQAVLSDSESGVQLSGSERTADASNGSLR 485
L+ E Q+ + +E E LQ Q QA + + E ++ +ERTA A LR
Sbjct: 1082 LKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELE---AERTARAKVEKLR 1138
Query: 486 G-LSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEA 544
LS + R G S + + KR+ + Q MR E
Sbjct: 1139 SDLSRELEEISERLEEAGGATSVQIEMN----------------KKREAEFQKMRRDLEE 1182
Query: 545 S----QDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANEL 600
+ + LRK+ +DS +E + LQR++ K + + + + E+ + S E
Sbjct: 1183 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE---KEKSEFKLELDDVTSNMEQ 1239
Query: 601 LSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE----------EEQEDA 650
+ + K+NL + + QA E R + E+ Q + + QR +L+ EE+E
Sbjct: 1240 IIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEAL 1299
Query: 651 VQDGARVR----RELERSHRQLEQLEGKRSVLAKELVEVR------------EALSRATL 694
+ R + +++E RQLE+ ++ LA L R E ++A L
Sbjct: 1300 ISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAEL 1359
Query: 695 QRDMLQAEKAEVAEALTKAEAGRV----ELELSMTKLRAEEASLQDSLSKLSALNESLAQ 750
QR +L +EVA+ TK E + ELE + KL ++++ ++A SL +
Sbjct: 1360 QR-VLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEK 1418
Query: 751 DK----LDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVAR---QG 803
K ++ L+ +E +A ++ + E +++ EE + E E ++ +
Sbjct: 1419 TKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARS 1478
Query: 804 LEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQL--SGRE-QELEQARREAQRQ 860
L L + A E + L T + E LQE+++ L+ QL G+ ELE+ R++ + +
Sbjct: 1479 LSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVE 1538
Query: 861 VEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQL 920
L+ A E EA + EH EG+ L R +LE ++ E++R+L
Sbjct: 1539 KLELQSALEEAEA-SLEH-----------EEGKIL-----RAQLEFNQIKA---EIERKL 1578
Query: 921 AQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREA 980
A+ + EQ + Q ++ + +T R +++ ++K D M +L A R A
Sbjct: 1579 AEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMA 1638
Query: 981 QASLREQRAAHE--EDLQRLQREKEAAWRELEAERAQLQSQ---LQREQEELLARLEAEK 1035
+ ++ ++ +D Q + A +L+ A ++ + LQ E EEL R E+
Sbjct: 1639 AEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEEL--RAVVEQ 1696
Query: 1036 EELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQ 1095
E S ++A +QE L+ SE+ Q L S+ T+L + L + E+E
Sbjct: 1697 TERSRKLA--EQE-----LIETSERVQLL---HSQNTSLINQKKKMESDLTQLQSEVEEA 1746
Query: 1096 KRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQA-RDLGKQRDSCLR 1154
++ ++ +E+ + + +L+ +E+ +AH + +++ EQ +DL + D
Sbjct: 1747 VQECRNAEEKAKKAITDAAMMAEELK--KEQDTSAHLERMKKNMEQTIKDLQHRLD---- 1800
Query: 1155 EAEEL-----RTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGA 1209
EAE++ + QL+ LE L EL Q++ ES +G + EL E
Sbjct: 1801 EAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDK 1860
Query: 1210 KEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGK-EAGELRTGL 1268
K L+ ++L+ VK + + A E +EQ L + R + + E R +
Sbjct: 1861 KNLLRLQDLVDKLQLKVKAYKRQ------AEEAEEQANTNLSKFRKVQHELDEAEERADI 1914
Query: 1269 QEVERSRLEARRELQELRRQMKMLDSE 1295
E + ++L A+ +++ + KM D E
Sbjct: 1915 AESQVNKLRAKS--RDIGAKQKMHDEE 1939
Score = 160 bits (406), Expect = 9e-39
Identities = 253/1145 (22%), Positives = 464/1145 (40%), Gaps = 190/1145 (16%)
Query: 847 EQELEQARREAQRQVEALERA-AREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLE 905
E+E+ + E R E LE++ AR KE E + +L +E L+L+
Sbjct: 848 EKEMATMKEEFGRIKETLEKSEARRKEL---------------EEKMVSLLQEKNDLQLQ 892
Query: 906 KEALEGSLFEVQRQLAQLEARREQLEAEGQAL---LLAKETLTGELAGLRQQIIATQEKA 962
+A + +L + + + QL + QLEA+ + + L +E + EL ++++ +
Sbjct: 893 VQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 952
Query: 963 SLDKELMAQKLVQAEREAQAS------LREQRAAHEEDLQRLQREKEAAWRELEAERAQL 1016
D + + L + E+E A+ L E+ A +E + +L +EK+A L+ Q
Sbjct: 953 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA----LQEAHQQA 1008
Query: 1017 QSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSE 1076
LQ E++++ LS+ L+Q+ D+ E EK+ + L E K L
Sbjct: 1009 LDDLQVEEDKV--------NSLSKSKVKLEQQVDDLEGSLEQEKKVRMDL-ERAKRKLEG 1059
Query: 1077 KLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVR 1136
L T+ S+ +++E K + + ++ +N S++ D E+ A
Sbjct: 1060 DLKLTQESI----MDLENDKLQLEEKLKKKEFDINQQNSKIED-----EQVLAL------ 1104
Query: 1137 RLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQ 1196
+LQ++ ++ + + E E RT +E R L REL E +L E+ VQ +
Sbjct: 1105 QLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIE 1164
Query: 1197 -------EAGELRRSLGEGAKEREA----LRRSN-----------EELRSAVKKAESERI 1234
E ++RR L E + EA LR+ + + L+ +K E E+
Sbjct: 1165 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1224
Query: 1235 SLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDS 1294
KL +D + + +A+ + K + L E EA+R L + Q L +
Sbjct: 1225 EFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQT 1284
Query: 1295 ENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQ----- 1349
EN L R+L E + ++ R + ++ L+++L + + + LQ A+
Sbjct: 1285 ENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDL 1344
Query: 1350 -RKLQEQEGEFRTRERRLLGSL--EEARGTEKQQLDHARGLELKLEAARAEAAELGLRLS 1406
R+ E+E E + +R+L E A+ K + D + E +LE A+ + A+ RL
Sbjct: 1345 LREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTE-ELEEAKKKLAQ---RLQ 1400
Query: 1407 AAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAP 1466
AE + + A+ + +E + + ++ L + R A R
Sbjct: 1401 DAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFD-----KIL 1455
Query: 1467 AEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERD 1526
AE + S S LE S S + ++ A E L+ L + +RE
Sbjct: 1456 AEWKQKYEESQSELESSQ----------KEARSLSTELFKLKNAYEESLEHLETFKRENK 1505
Query: 1527 ELRTQTSALNRQLAE-------MEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQA 1579
L+ + S L QL E +E R +LQ A+ E+E + +G++ Q
Sbjct: 1506 NLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQL 1565
Query: 1580 ELALQEESVRRSERERRATLDQVA-TLERSLQATESELRASQEKISKMKANETKLEGDKR 1638
E + + R E+ ++Q +R + + ++ L A +++ + K+EGD
Sbjct: 1566 EFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLN 1625
Query: 1639 RLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDR--------------EAQAQALQD 1684
++ L + + + Q +SL+ L+ +++ L D E + LQ
Sbjct: 1626 EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA 1685
Query: 1685 RVDSLQRQVADSE----VKAGTLQLTVERL------NGALAK------------------ 1716
++ L+ V +E + L T ER+ N +L
Sbjct: 1686 ELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEE 1745
Query: 1717 -VEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQ 1775
V+E A + +T+A A + L +D + HL++ E + LQ RLD A Q
Sbjct: 1746 AVQECRNAEEKAKKAITDA-AMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQ 1804
Query: 1776 -ALSEARKQSSSLGEQVQTLRGE---------------------VADLELQRVEAEGQLQ 1813
AL +KQ L +V+ L GE + +L Q E + L
Sbjct: 1805 IALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLL 1864
Query: 1814 QLREVL-----------RQRQEGEAAA---LNTVQKLQDERRLLQERLGSLQRALAQLEA 1859
+L++++ RQ +E E A L+ +K+Q E +ER + + +L A
Sbjct: 1865 RLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRA 1924
Query: 1860 EKREV 1864
+ R++
Sbjct: 1925 KSRDI 1929
Score = 142 bits (357), Expect = 4e-33
Identities = 244/1182 (20%), Positives = 502/1182 (42%), Gaps = 169/1182 (14%)
Query: 872 EALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLE 931
E + E + + A+ G+ + E ++ ++AL + ++ + +L
Sbjct: 776 EEMRDERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLY 835
Query: 932 AEGQALLLAKETLTGELAGLRQQ---IIATQEKASLDKELMAQKLVQAEREAQASLREQR 988
+ + LL + ET E+A ++++ I T EK+ ++ + +K+V +E L+ Q
Sbjct: 836 FKIKPLLKSAET-EKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKN-DLQLQV 893
Query: 989 AAHEEDLQRLQREKEAAWR---ELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAAL 1045
A +++L + + + +LEA+ ++ +L+ ++EE+ A L A+K +L +E + L
Sbjct: 894 QAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLE-DEEEMNAELTAKKRKLEDECSEL 952
Query: 1046 QQERDE-GLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQE 1104
+++ D+ L LA+ EK++ + E++ L+E++ G L I ++ ++K+ Q +
Sbjct: 953 KKDIDDLELTLAKVEKEKHAT--ENKVKNLTEEMAG----LDEIIAKLTKEKKALQEAHQ 1006
Query: 1105 QDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLG-------KQRDSCLREAE 1157
Q L DL+ + ++ + +V+ L++Q DL K R R
Sbjct: 1007 Q----------ALDDLQVEEDKVNSLSKSKVK-LEQQVDDLEGSLEQEKKVRMDLERAKR 1055
Query: 1158 ELRTQLRLLEDARDGLRRELLEAQRKLRE-----SQEGREVQRQE--AGELRRSLGEGAK 1210
+L L+L +++ L + L+ + KL++ +Q+ +++ ++ A +L++ L E
Sbjct: 1056 KLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQA 1115
Query: 1211 EREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQE 1270
E L E R+A K E R L E+ ++L +EAG + E
Sbjct: 1116 RIEELEEELEAERTARAKVEKLRSDLSRELEEISERL-----------EEAGGATSVQIE 1164
Query: 1271 VERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQR 1330
+ + R E Q++RR + E A + LR++
Sbjct: 1165 MNKKR---EAEFQKMRRDL------------------------EEATLQHEATAAALRKK 1197
Query: 1331 LLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELK 1390
A L LQ ++KL++++ EF+ L++ +Q + LE
Sbjct: 1198 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLE-------LDDVTSNMEQIIKAKANLEKV 1250
Query: 1391 LEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLG---GLRSALRRG-LGL 1446
+A E ++L A+ + A+++ + QL L S L RG L
Sbjct: 1251 SRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSY 1310
Query: 1447 GRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEA 1506
+ R + E G+ N+ + A A D D
Sbjct: 1311 TQQMEDLKRQL----------EEEGKAKNALAH--------------ALQSARHDCD--- 1343
Query: 1507 VRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDS-ATSRARQLQKAVAESEE 1565
LRE +E A+ E L+ S N ++A+ + ++ A R +L++A + +
Sbjct: 1344 ---LLREQYEEETEAKAE---LQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1397
Query: 1566 ARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISK 1625
+ + + V A+ + E++ R + E D + +ERS A + L Q K
Sbjct: 1398 RLQDAEEAVEAVNAKCSSLEKTKHRLQNEIE---DLMVDVERS-NAAAAALDKKQRNFDK 1453
Query: 1626 MKAN-ETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQD 1684
+ A + K E + L+ E+R++ EL + L+ + S L + + + LQ+
Sbjct: 1454 ILAEWKQKYEESQSELES--SQKEARSLSTELFK--LKNAYEESLEHLETFKRENKNLQE 1509
Query: 1685 RVDSLQRQVADS-----EVKAGTLQLTVERLN------GALAKVEESEGALRDKVRGLTE 1733
+ L Q+ + E++ QL VE+L A A +E EG + +
Sbjct: 1510 EISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQ 1569
Query: 1734 ALAQSSASLNSTRDKNLHLQKALTACEHDRQV--LQERLDAARQALSEARKQSSSLGEQV 1791
A+ L + +D+ + K H R V LQ LDA ++ +E + + +
Sbjct: 1570 IKAEIERKL-AEKDEEMEQAKR----NHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDL 1624
Query: 1792 QTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQ 1851
+ +++ EA+ Q++ L+ +L+ Q A+ L++ +++ R LQ
Sbjct: 1625 NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQ 1684
Query: 1852 RALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLT 1911
L +L A + ERS ++A + ++ ER +L H L +K +++ LT
Sbjct: 1685 AELEELRAVVEQTERSR------KLAEQELIETSERVQL-LHSQNTSLINQKKKMESDLT 1737
Query: 1912 GAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERT 1971
+ E+ EA ++ + E + +++ + A + + +++ + +ER++ QT +
Sbjct: 1738 QLQSEVEEAVQECRNAEEKA---KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD 1794
Query: 1972 LEAR--------ERAHRQRVRGLEEQVSTLKGQLQQELRRSS 2005
L+ R + +++++ LE +V L+G+L+ E +R++
Sbjct: 1795 LQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNA 1836
Score = 141 bits (355), Expect = 7e-33
Identities = 241/1128 (21%), Positives = 471/1128 (41%), Gaps = 147/1128 (13%)
Query: 889 EREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGEL 948
E+E T+ EE R+ KE LE S EARR++LE + +LL K L
Sbjct: 848 EKEMATMKEEFGRI---KETLEKS-----------EARRKELEEKMVSLLQEKNDL---- 889
Query: 949 AGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRE 1008
+ Q+ A Q+ + D E +L++ + + +A ++E E++ + + E A R+
Sbjct: 890 ---QLQVQAEQDNLN-DAEERCDQLIKNKIQLEAKVKEMNERLEDE-EEMNAELTAKKRK 944
Query: 1009 LEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQER---DEGLLLAESEKQQALS 1065
LE E ++L+ + + E LA++E EK ++ L +E DE + EK+ +
Sbjct: 945 LEDECSELKKDID-DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK---A 1000
Query: 1066 LKESEKTALSEKLMGTR--HSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQ 1123
L+E+ + AL + + +SL+ +++E+Q D + EQ++ +R
Sbjct: 1001 LQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKK-----------VRMD 1049
Query: 1124 REEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRE---LLEA 1180
E A +++ QE DL + L+ E+L+ + + + E L+
Sbjct: 1050 LERAKRKLEGDLKLTQESIMDLENDK---LQLEEKLKKKEFDINQQNSKIEDEQVLALQL 1106
Query: 1181 QRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKA---ESERISLK 1237
Q+KL+E+Q E +E R + + K R L R EE+ +++A S +I +
Sbjct: 1107 QKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1166
Query: 1238 LANEDKEQKLAL-LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSEN 1296
E + QK+ LEEA A LR ++ S E ++ L+R + L+ E
Sbjct: 1167 KKREAEFQKMRRDLEEATLQHEATAAALR---KKHADSVAELGEQIDNLQRVKQKLEKEK 1223
Query: 1297 TRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQE 1356
+ EL ++ + ++++K +A+LE + R L++Q
Sbjct: 1224 SEFKLELDDVTSNM------------------EQIIKAKANLEKV-------SRTLEDQA 1258
Query: 1357 GEFRTRERRLLGSLEEARGTEKQQLDHARG-LELKLEAARAEAAELGLRLSAAEGRAQGL 1415
E+R + SL + T++ +L G L +LE A ++L +G
Sbjct: 1259 NEYRVKLEEAQRSLNDFT-TQRAKLQTENGELARQLEEKEALISQL----------TRGK 1307
Query: 1416 EAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLN 1475
+ ++E +R E + G ++AL L R D E E
Sbjct: 1308 LSYTQQMEDLKRQLEEE-GKAKNALAHALQSARHDC------------DLLREQYEEETE 1354
Query: 1476 SPSTLE--CSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTS 1533
+ + L+ S + + E + A ++ Q L+ A+
Sbjct: 1355 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEA-------VE 1407
Query: 1534 ALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSER 1593
A+N + + +E + + L V S A ++D + LA ++ S+
Sbjct: 1408 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1467
Query: 1594 ERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVK 1653
E ++ + +L L ++ S E + K L+ + L E L +
Sbjct: 1468 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHE 1527
Query: 1654 LELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGA 1713
LE R+ LE E + L + EA + + ++ L+ Q+ +++KA + E
Sbjct: 1528 LEKVRKQLEVEKLELQSALEEAEASLEHEEGKI--LRAQLEFNQIKAEIERKLAE----- 1580
Query: 1714 LAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAA 1773
K EE E A R+ R + ++L S + +R++ L ++K + E D ++ +L A
Sbjct: 1581 --KDEEMEQAKRNHQR-VVDSLQTSLDAETRSRNEVLRVKKKM---EGDLNEMEIQLSHA 1634
Query: 1774 RQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALN-- 1831
+ +EA+KQ SL ++ + ++ D V A L++ ++ +R A L
Sbjct: 1635 NRMAAEAQKQVKSLQSLLKDTQIQLDDA----VRANDDLKENIAIVERRNNLLQAELEEL 1690
Query: 1832 --TVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREK 1889
V++ + R+L ++ L + L ++ + ++E D L+ +++ +E
Sbjct: 1691 RAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQEC 1750
Query: 1890 LRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQ 1949
+ E A+K D + EL+ + Q LE +EQ+ Q +D +
Sbjct: 1751 RNAEE-----KAKKAITDAAMMAEELK--KEQDTSAHLERMKKNMEQTIKDLQHRLD-EA 1802
Query: 1950 QQLELQ---QEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLK 1994
+Q+ L+ +++++L + + E LEA ++ + + V+G+ + +K
Sbjct: 1803 EQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIK 1850
Score = 108 bits (270), Expect = 5e-23
Identities = 184/920 (20%), Positives = 373/920 (40%), Gaps = 86/920 (9%)
Query: 5 LARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREI-VTRNLSQPE 63
L + ++V + LE + LE + ++ + DL D +E + + S+ E
Sbjct: 1040 LEQEKKVRMDLERAKRKLEGDLKLTQESI--MDLENDKLQLEEKLKKKEFDINQQNSKIE 1097
Query: 64 SPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALR 123
+L L Q + L++EL A+ R +L+ + +SERLE+A
Sbjct: 1098 DEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGG 1157
Query: 124 LEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQY 183
++E + R Q ++RR L+E + A +++ A V L +I
Sbjct: 1158 ATSVQIEMNKKREAEFQ--KMRRDLEEATLQHEATAAAL---RKKHADSVAELGEQIDNL 1212
Query: 184 KKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQL 243
++ +LE++ +E +L+ +E+ + A+L +V+ L +Q
Sbjct: 1213 QRVKQKLEKE--------------KSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQA 1258
Query: 244 DQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQV 303
++ + E+ ++ ND+T R +L+ R+ E A S L R
Sbjct: 1259 NE----YRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQ-------LTRGK 1307
Query: 304 VGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALL 363
+ + + + ++K R L + G + A+Q A E EA E Q +L
Sbjct: 1308 LSYTQQMEDLK----RQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVL 1363
Query: 364 QAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDL 423
E + + E D Q+ + + K L+ R+ + AV+ + + ++ L
Sbjct: 1364 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRL 1423
Query: 424 TEKLEAL--ESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASN 481
++E L + R AA + + L + Q ES +L S++ A + +
Sbjct: 1424 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKY---EESQSELESSQKEARSLS 1480
Query: 482 GSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDS--------STLALIHSALHKRQL 533
L L S + R + ++ L + L +L
Sbjct: 1481 TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKL 1540
Query: 534 QVQDMRGRYEAS---------------QDLLGTLRKQLSDSESERRALEEQLQRLRDKTD 578
++Q EAS + + ++L++ + E + QR+ D
Sbjct: 1541 ELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQ 1600
Query: 579 GAMQAHEDAQREVQRLRSANE-LLSREKSNLAHSLQV---AQQQAEELRQEREKLQAAQE 634
++ A ++ EV R++ E L+ + L+H+ ++ AQ+Q + L+ + Q +
Sbjct: 1601 TSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLD 1660
Query: 635 ELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATL 694
+ R D L+E + ++ ELE +EQ E R + +EL+E E +
Sbjct: 1661 DAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHS 1720
Query: 695 QRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDK-- 752
Q L +K ++ LT+ ++ E+E ++ + R E + +++ + + E L +++
Sbjct: 1721 QNTSLINQKKKMESDLTQLQS---EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT 1777
Query: 753 -LDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQ-ERLE--------ELRLEQEVARQ 802
L R+ +E+ LQ R +AEQ A ++Q ++LE EL EQ+ +
Sbjct: 1778 SAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAE 1837
Query: 803 GLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVE 862
++G +R +E+ + L Q + +LQ+ + +L ++ +++ E+A +A +
Sbjct: 1838 SVKG-MRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLS 1896
Query: 863 ALERAAREKEALAKEHAGLA 882
+ E + A+E A +A
Sbjct: 1897 KFRKVQHELDE-AEERADIA 1915
Score = 92.4 bits (228), Expect = 4e-18
Identities = 123/532 (23%), Positives = 241/532 (45%), Gaps = 73/532 (13%)
Query: 1512 REFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEA----- 1566
+E +++ S +E+++L+ Q A L + E D QL+ V E E
Sbjct: 873 KELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEE 932
Query: 1567 ---------RRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESEL- 1616
+R ++ S ++ ++ E ++ + E+E+ AT ++V L + + +
Sbjct: 933 EMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIA 992
Query: 1617 RASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDRE 1676
+ ++EK + +A++ L+ + +V S+S+ VKLE Q LEG L++ + D E
Sbjct: 993 KLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSK-VKLEQQVDDLEGSLEQEKKVRMDLE 1051
Query: 1677 AQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALA 1736
+ L+ G L+LT E ++ +E + L +K++ +
Sbjct: 1052 RAKRKLE-----------------GDLKLTQE----SIMDLENDKLQLEEKLKKKEFDIN 1090
Query: 1737 QSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTL-- 1794
Q ++ + + L LQK L + + L+E L+A R A ++ K S L +++ +
Sbjct: 1091 QQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISE 1150
Query: 1795 ----RGEVADLELQ-RVEAEGQLQQLREVLRQ---RQEGEAAALNTVQKLQDERRLLQER 1846
G ++++ + E + Q++R L + + E AAAL +K D L E+
Sbjct: 1151 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR--KKHADSVAELGEQ 1208
Query: 1847 LGSLQRALAQLEAEKREVERSALRLEKDRVA--------LRRTLDKVERE-KLRSHEDTV 1897
+ +LQR +LE EK E +LE D V + L+KV R + +++E V
Sbjct: 1209 IDNLQRVKQKLEKEKSE-----FKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRV 1263
Query: 1898 RL-SAEKGRLDRTLTGAEL--ELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL 1954
+L A++ D T A+L E E RQ+++ EA + L + ++ QQ +L
Sbjct: 1264 KLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRG------KLSYTQQMEDL 1317
Query: 1955 QQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSA 2006
++++E A+ L++ R +R E+ + K +LQ+ L ++++
Sbjct: 1318 KRQLEEEGKAKNALAHALQS-ARHDCDLLREQYEEETEAKAELQRVLSKANS 1368
Score = 81.6 bits (200), Expect = 7e-15
Identities = 100/455 (21%), Positives = 194/455 (42%), Gaps = 80/455 (17%)
Query: 1561 AESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQ 1620
AE+E+ ++ ++ L E + E + + L + L+ +QA + L ++
Sbjct: 845 AETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAE 904
Query: 1621 EKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQ 1680
E+ ++ N+ +LE + + E L+ E +L ++R LE E + + D
Sbjct: 905 ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDD------ 958
Query: 1681 ALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVR-------GLTE 1733
L+LT LAKVE+ + A +KV+ GL E
Sbjct: 959 ----------------------LELT-------LAKVEKEKHATENKVKNLTEEMAGLDE 989
Query: 1734 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQT 1793
+A+ T++K LQ+A D QV ++++++ K L +QV
Sbjct: 990 IIAK------LTKEKKA-LQEAHQQALDDLQVEEDKVNS-------LSKSKVKLEQQVDD 1035
Query: 1794 LRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRA 1853
L G + + R++ E ++L L+ QE ++ L++++ L+E+L +
Sbjct: 1036 LEGSLEQEKKVRMDLERAKRKLEGDLKLTQE-------SIMDLENDKLQLEEKLKKKEFD 1088
Query: 1854 LAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGA 1913
+ Q ++ + + AL+L+K + ++++E E E T R EK R D
Sbjct: 1089 INQQNSKIEDEQVLALQLQKKLKENQARIEELEEE--LEAERTARAKVEKLRSD-----L 1141
Query: 1914 ELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLE 1973
EL E ++++ V Q+E++ ++++ E Q+ L A Q E T
Sbjct: 1142 SRELEEISERLEEAGGATSV--------QIEMN-KKREAEFQKMRRDLEEATLQHEATAA 1192
Query: 1974 ARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPF 2008
A + H V L EQ+ L+ +++Q+L + + F
Sbjct: 1193 ALRKKHADSVAELGEQIDNLQ-RVKQKLEKEKSEF 1226
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 184 bits (466), Expect = 1e-45
Identities = 264/1201 (21%), Positives = 513/1201 (42%), Gaps = 165/1201 (13%)
Query: 772 RQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQ 831
+ + E+E +EE +++++ L +E ++ LE+++ TL E++
Sbjct: 847 KSAETEKEMATMKEEFQKIKD--------------ELAKSEAKRKELEEKMVTLLKEKND 892
Query: 832 LQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAERE 891
LQ Q+ Q + E L A + L K L ++
Sbjct: 893 LQLQV---------------------QAEAEGLADAEERCDQLIKTKIQLEAKIKEVTER 931
Query: 892 GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 951
E L +K LE E+++ + LE ++E E A + LT E+AGL
Sbjct: 932 AEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 991
Query: 952 RQQII-ATQEKASLDKELMAQKL--VQAEREAQASLREQRAAHE---EDLQRLQREKEAA 1005
+ I T+EK +L +E Q L +QAE + +L + + E +DL+ +++
Sbjct: 992 DETIAKLTKEKKAL-QEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKL 1050
Query: 1006 WRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALS 1065
+LE + +L+ L+ QE ++ +E EK++L E++ ++E + L ++ E +QAL
Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIM-DIENEKQQLDEKLK--KKEFEISNLQSKIEDEQALG 1107
Query: 1066 LKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQRE 1125
++ +K K + R +E ER R +Q D L+ EL ++ + E
Sbjct: 1108 IQLQKKI----KELQARIEELEEEIEAERASRAKAEKQRSD------LSRELEEISERLE 1157
Query: 1126 EAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLR 1185
EA A + ++ ++ K+R++ E Q+ R
Sbjct: 1158 EAGGATSAQI--------EMNKKREA---------------------------EFQKMRR 1182
Query: 1186 ESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQ 1245
+ +E A LR+ + E L + L+ +K E E+ +K+ +D
Sbjct: 1183 DLEEATLQHEATAATLRKKHADSVAE---LGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS 1239
Query: 1246 KLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAE 1305
+ + +A+ + K L L E++ E +R + +L Q L +E+ R+L E
Sbjct: 1240 NVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDE 1299
Query: 1306 LQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQ------RKLQEQEGEF 1359
+ ++ R ++ ++ L+++L + + + LQ ++ R+ E+E E
Sbjct: 1300 KEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQES 1359
Query: 1360 RTRERRLL--GSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEA 1417
+ +R L + E A+ K + D + E +LE A+ + A+ RL AAE + + A
Sbjct: 1360 KAELQRALSKANTEVAQWRTKYETDAIQRTE-ELEEAKKKLAQ---RLQAAEEHVEAVNA 1415
Query: 1418 ELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSP 1477
+ A +E ++ + ++ L + R A R AE + +
Sbjct: 1416 KCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFD-----KILAEWKQKCEETH 1470
Query: 1478 STLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNR 1537
+ LE S S + ++ A E L +L + +RE L+ + S L
Sbjct: 1471 AELEAS----------QKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1520
Query: 1538 QLA-------EMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRR 1590
Q+A E+E + +LQ A+ E+E + +G++ +Q EL + V R
Sbjct: 1521 QIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1580
Query: 1591 SERERRATLDQV----ATLERSLQAT-ESELRASQEKISKMKANETKLEGDKRRLKEVLD 1645
E+ +DQ+ + S+Q+T ++E+R+ + I K K+EGD ++ L+
Sbjct: 1581 KIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKK----KMEGDLNEMEIQLN 1636
Query: 1646 ASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQL 1705
+ + R+ +G L+ +++ L D AL+ + D L+ Q+A E +A LQ
Sbjct: 1637 HANRMAAEALRNYRNTQGILKDTQIHLDD------ALRSQED-LKEQLAMVERRANLLQA 1689
Query: 1706 TVERLNGALAKVEESEGALRDKVRGLTE---ALAQSSASLNSTRDKNLHLQKALTACEHD 1762
+E L L + E S ++ +E L + SL +T+ K L+ ++ + +
Sbjct: 1690 EIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK---LETDISQMQGE 1746
Query: 1763 RQ-VLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQ 1821
+ +LQE +A +A +A ++ + E+++ + A LE + E Q ++++ +
Sbjct: 1747 MEDILQEARNAEEKA-KKAITDAAMMAEELKKEQDTSAHLERMKKNME---QTVKDLQLR 1802
Query: 1822 RQEGEAAAL----NTVQKLQDERRLLQERLGSLQR----ALAQLEAEKREVERSALRLEK 1873
E E AL +QKL+ R L+ + S Q+ A+ L +R V+ + E+
Sbjct: 1803 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEE 1862
Query: 1874 DRVALRRTLDKVER--EKLRSHEDTVRLSAEKGRLD-RTLTGAELELAEAQRQIQQLEAQ 1930
DR + R D V++ K++S++ + E+ + + EL EA+ + E+Q
Sbjct: 1863 DRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQ 1922
Query: 1931 V 1931
V
Sbjct: 1923 V 1923
Score = 174 bits (441), Expect = 8e-43
Identities = 253/1196 (21%), Positives = 500/1196 (41%), Gaps = 169/1196 (14%)
Query: 552 LRKQLSDSESERRALEEQLQRL-RDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAH 610
++ +L+ SE++R+ LEE++ L ++K D +Q +A+ ++L+ + K L
Sbjct: 865 IKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLI-KTKIQLEA 923
Query: 611 SLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQL-- 668
++ ++AE+ + +L A + +L + L+++ +D A+V +E + ++
Sbjct: 924 KIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 983
Query: 669 --EQLEGKRSVLAKELVEVREALSRATLQR-DMLQAEKAEVAEALTKAEAGRVELELSMT 725
E++ G +AK L + ++AL A Q D LQAE+ +V LTKA+
Sbjct: 984 LTEEMAGLDETIAK-LTKEKKALQEAHQQTLDDLQAEEDKV-NTLTKAKI---------- 1031
Query: 726 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVARE 785
KL + L+ SL + L L + K L + +E ++ ++Q +++
Sbjct: 1032 KLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEF 1091
Query: 786 EQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSG 845
E L+ +++ L+ ++ + E LE+++ R R++ ++Q + LSR+L
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151
Query: 846 REQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLE 905
+ LE+A Q+E ++ RE E Q + + E TL EAT L
Sbjct: 1152 ISERLEEAGGATSAQIEMNKK--REAE----------FQKMRRDLEEATLQHEATAATLR 1199
Query: 906 KEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLD 965
K+ + S+ E+ Q+ L+ +++LE E + + + L + T KA +
Sbjct: 1200 KKHAD-SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN--------VETVSKAKGN 1250
Query: 966 KELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQE 1025
E M + L E Q S + + EE+ QRL + A L+ E + QL E+E
Sbjct: 1251 LEKMCRTL-----EDQLS---ELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLD-EKE 1301
Query: 1026 ELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSL 1085
L+++L K+ +++I L+++ +E + K AL+ L +RH
Sbjct: 1302 ALVSQLSRGKQAFTQQIEELKRQLEEEI---------------KAKNALAHALQSSRHD- 1345
Query: 1086 ATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDL 1145
L E+ + + +S+ E R+ A T E+ R + E A +E L+E + L
Sbjct: 1346 --CDLLREQYEEEQESKAELQRALSKANT-EVAQWRTKYETDAIQRTEE---LEEAKKKL 1399
Query: 1146 GKQRDSCLREAEELRTQLRLLEDARDGLRRE----LLEAQR----------KLRESQEGR 1191
++ + E + + LE + L+ E +L+ +R K R +
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL 1459
Query: 1192 EVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLE 1251
+Q+ E L KE +L ++++A +++ + +LK N++ +Q+++ L
Sbjct: 1460 AEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT 1519
Query: 1252 EARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLA 1311
E GK EL ++VE+ + E + L+E ++ + + R+ EL +++ +
Sbjct: 1520 EQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVD 1579
Query: 1312 LGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER--RLLGS 1369
R+ K E ++ R +++ + + E R+R RL
Sbjct: 1580 ----------------RKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKK 1623
Query: 1370 LEEARGTEKQQLDHARGLELKLEAARAEAAELG------LRLSAAEGRAQGLEAELARVE 1423
+E + QL+HA + EA R G + L A + L+ +LA VE
Sbjct: 1624 MEGDLNEMEIQLNHAN--RMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVE 1681
Query: 1424 VQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECS 1483
+ +A++ LR+ L + + R + DA + S +
Sbjct: 1682 RRANLLQAEIEELRATLEQ--------TERSRKIAEQELLDASERVQLLHTQNTSLI--- 1730
Query: 1484 PGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQL---- 1539
+ + D ++G + + LQE R+A+ + + T + + +L
Sbjct: 1731 -----------NTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779
Query: 1540 ---AEMEAERDSATSRARQLQKAVAESE--------------EAR-RSVDGRLSGVQAEL 1581
A +E + + + LQ + E+E EAR R ++G + Q
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRN 1839
Query: 1582 ALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLK 1641
A + +R+ ER +V L + + Q+ + K++A K++ KR+ +
Sbjct: 1840 AEAVKGLRKHER-------RVKELTYQTEEDRKNILRLQDLVDKLQA---KVKSYKRQAE 1889
Query: 1642 EVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSE 1697
E + S + K R L+ EL+ + E+Q L+ + + +V E
Sbjct: 1890 EAEEQSNTNLAKF----RKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
Score = 173 bits (439), Expect = 1e-42
Identities = 210/960 (21%), Positives = 417/960 (43%), Gaps = 110/960 (11%)
Query: 520 TLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDG 579
TLA + H + +V+++ + + L K+ + + + LQ DK +
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 580 AMQAHEDAQREVQRLRSANEL-------LSREKSNLAHSLQVAQQQAEELRQEREKLQAA 632
+A +++V L + E L R K L L++AQ+ ++ E+++L
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 633 QEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRA 692
++ + L+ + ED G +++++++ ++E+LE +E+ R + ++A
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELE-------EEIEAERASRAKA 1138
Query: 693 TLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRA----------EEASLQDSLSKLS 742
QR L E E++E L +A G ++ M K R EEA+LQ + +
Sbjct: 1139 EKQRSDLSRELEEISERLEEA-GGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA-A 1196
Query: 743 ALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQ 802
L + A +L + L+ K L+ + + + E E + + + E +
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCR 1256
Query: 803 GLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVE 862
LE L + +E ++ + L +R +LQ + + SRQL +E + Q R Q +
Sbjct: 1257 TLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQ 1316
Query: 863 ALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ 922
+E R+ E K LA L ++ + L E+ + K L+ +L + ++AQ
Sbjct: 1317 QIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQ 1376
Query: 923 LEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQA 982
+ E I E+ K+ +AQ+L AE +A
Sbjct: 1377 WRTKYET------------------------DAIQRTEELEEAKKKLAQRLQAAEEHVEA 1412
Query: 983 SLREQRAAHEEDLQRLQREKEAAWRELEAERA-------------QLQSQLQREQEELLA 1029
+ + A+ E+ QRLQ E E ++E A ++ ++ +++ EE A
Sbjct: 1413 -VNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHA 1471
Query: 1030 RLEAEKEE---LSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLM--GTR-H 1083
LEA ++E L E+ ++ +E L E+ K++ +L++ E + L+E++ G R H
Sbjct: 1472 ELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ-EISDLTEQIAEGGKRIH 1530
Query: 1084 SLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQAR 1143
L I ++E++K + Q+ E+ +++ E + LR Q E ++ R++ E+
Sbjct: 1531 ELEKIKKQVEQEKCELQAALEEAEASLEH--EEGKILRIQLE-LNQVKSEVDRKIAEKDE 1587
Query: 1144 DLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRR 1203
++ + + + +R E +++ L DA R + + ++K+ E+Q A +
Sbjct: 1588 EIDQLKRNHIRIVESMQSTL----DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAA 1643
Query: 1204 SLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGE 1263
EALR + + +K + + ED +++LA++E + E E
Sbjct: 1644 ---------EALR-NYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEE 1693
Query: 1264 LRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRE 1323
LR L++ ERSR A +EL + ++++L ++NT L +L+ ++ + ++ +E
Sbjct: 1694 LRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQE 1753
Query: 1324 TLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDH 1383
++ K +M +EL+ +E+ LE + +Q +
Sbjct: 1754 ARNAEEKAKKAITDAAMMAEELK---------------KEQDTSAHLERMKKNMEQTV-- 1796
Query: 1384 ARGLELKLEAARAEAAELGLR-LSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRR 1442
+ L+L+L+ A A + G + + E R + LE E+ Q+R AEA + GLR RR
Sbjct: 1797 -KDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVE--SEQKRNAEA-VKGLRKHERR 1852
Score = 167 bits (422), Expect = 1e-40
Identities = 273/1178 (23%), Positives = 510/1178 (43%), Gaps = 178/1178 (15%)
Query: 174 QRLQGKILQYKKRCSELEQQ---LLERSGELEQQRLRDTEHSQDLESALIRLEEEQ-QRS 229
Q+++ ++ + + + ELE++ LL+ +L+ Q + E D E +L + + Q
Sbjct: 863 QKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLE 922
Query: 230 ASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYF 289
A + +V E+ + N L+ RK+ ++ + +K+++ E + E+ +A
Sbjct: 923 AKIKEVT----ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA-- 976
Query: 290 SNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLA 349
+++ L ++ G +++ L + +A+QEA L+
Sbjct: 977 --TENKVKNLTEEMAGLDETIAK---------------LTKEKKALQEAHQQTLDDLQAE 1019
Query: 350 ESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRL 409
E + + + L+ Q+++ L + +EK L + DL++A +L LA + +
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDD-LEGSLEQEKKL-----RMDLERAKRKLE-GDLKLAQESI 1072
Query: 410 EKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEG--LQQTLRDLAQAVLSDSESG 467
EK Q+++ L +K + +L Q+ +E E G LQ+ +++L QA + + E
Sbjct: 1073 MDIENEKQQLDEKLKKKEFEISNL----QSKIEDEQALGIQLQKKIKEL-QARIEELEEE 1127
Query: 468 VQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSA 527
++ + R S LS + R G +T A I
Sbjct: 1128 IEAERASRAKAEKQRS--DLSRELEEISERLEEAG---------------GATSAQIEMN 1170
Query: 528 LHKRQLQVQDMRGRYEAS----QDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQA 583
KR+ + Q MR E + + TLRK+ +DS +E + LQR++ K + +
Sbjct: 1171 -KKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLE---KE 1226
Query: 584 HEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRL 643
+ + E+ L S E +S+ K NL + + Q EL+ + E+ Q +L QR RL
Sbjct: 1227 KSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRL 1286
Query: 644 E----------EEQEDAVQDGARVRR----ELERSHRQLEQLEGKRSVLAKELVEVREAL 689
+ +E+E V +R ++ ++E RQLE+ ++ LA L R
Sbjct: 1287 QTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDC 1346
Query: 690 SRATLQRDMLQAEKAEVAEALTKAEA---------------GRVELELSMTK----LRAE 730
Q + Q KAE+ AL+KA ELE + K L+A
Sbjct: 1347 DLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAA 1406
Query: 731 EASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERL 790
E ++ +K ++L ++ + + ++ L+ +E +A ++ + E +++
Sbjct: 1407 EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKC 1466
Query: 791 EELRLEQEVAR---QGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLS--- 844
EE E E ++ + L L + A E QL TL+ E LQ++++ L+ Q++
Sbjct: 1467 EETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG 1526
Query: 845 GREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRL 904
R ELE+ +++ +++ L+ A E EA + EH EG+ L R++L
Sbjct: 1527 KRIHELEKIKKQVEQEKCELQAALEEAEA-SLEH-----------EEGKIL-----RIQL 1569
Query: 905 EKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLA-KETLTGELAGLRQQIIATQEKAS 963
E ++ EV R++A+ + +QL+ ++ + + TL E+ R I ++K
Sbjct: 1570 ELNQVKS---EVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRS-RNDAIRLKKKME 1625
Query: 964 LDKELMAQKLVQAEREAQASLREQR---------AAHEEDLQRLQREKEAAWRELEAERA 1014
D M +L A R A +LR R H +D R Q + + +E RA
Sbjct: 1626 GDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVE-RRA 1684
Query: 1015 QLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTAL 1074
L LQ E EEL A L E+ E S +IA +QE LL SE+ Q L ++ T+L
Sbjct: 1685 NL---LQAEIEELRATL--EQTERSRKIA--EQE-----LLDASERVQLL---HTQNTSL 1729
Query: 1075 SEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQE 1134
++ + EME ++A++ +E+ + + +L+ +E+ +AH +
Sbjct: 1730 INTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELK--KEQDTSAHLER 1787
Query: 1135 VRRLQEQ-ARDLGKQRDSCLREAEEL-----RTQLRLLEDARDGLRRELLEAQRKLRESQ 1188
+++ EQ +DL + D EAE+L + Q++ LE L E+ Q++ E+
Sbjct: 1788 MKKNMEQTVKDLQLRLD----EAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843
Query: 1189 EGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLA 1248
+G + EL E K L+ ++L++ VK + + A E +EQ
Sbjct: 1844 KGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ------AEEAEEQSNT 1897
Query: 1249 LLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELR 1286
L + R +L+ L+E E A ++ +LR
Sbjct: 1898 NLAKFR--------KLQHELEEAEERADIAESQVNKLR 1927
Score = 152 bits (383), Expect = 4e-36
Identities = 238/1104 (21%), Positives = 439/1104 (39%), Gaps = 158/1104 (14%)
Query: 94 EDLLAQSRAERDELAIKYNAVSERLEQA-LRLEPGELETQEPRGLVRQSVELRRQLQEEQ 152
E++ A+ A++ +L + + + + ++ L L E E V+ E L E
Sbjct: 936 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETI 995
Query: 153 ASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHS 212
A ++ +A QE Q+ +Q + K+ K +LEQQ+ + G LEQ++ +
Sbjct: 996 AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEK----KLR 1051
Query: 213 QDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELE 272
DLE A +LE + + + +E + + Q L E ++K + + + ++E
Sbjct: 1052 MDLERAKRKLEGDLK----------LAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIE 1101
Query: 273 HREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTS 332
+A + ++ +R+ L ++ R S K E+ L EL S
Sbjct: 1102 DEQALGIQLQKKIKEL----QARIEELEEEIEAER--ASRAK--AEKQRSDLSRELEEIS 1153
Query: 333 RAVQEAGLGLSTGLRLAESR-AEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLD 391
++EAG S + + + R AE ++ L +A L+ + LR+K
Sbjct: 1154 ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD--------S 1205
Query: 392 KADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQ 451
A+L ++ L ++LEK+ E DL +E + + + E + +
Sbjct: 1206 VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK---------GNLEKMCR 1256
Query: 452 TLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGP 511
TL D + S E +L A G L+ SG+
Sbjct: 1257 TLEDQLSELKSKEEEQQRLIND---LTAQRGRLQTESGE--------------------- 1292
Query: 512 SPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQ 571
L +++ V + +A + L++QL + + AL LQ
Sbjct: 1293 ------------FSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQ 1340
Query: 572 RLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQV-AQQQAEELRQEREK-- 628
R D + +E+ Q L+ A + E + + A Q+ EEL + ++K
Sbjct: 1341 SSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLA 1400
Query: 629 --LQAAQE----------ELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRS 676
LQAA+E L + + RL+ E ED + D +ER++ L+ K+
Sbjct: 1401 QRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD-------VERTNAACAALDKKQR 1453
Query: 677 VLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQD 736
K L E ++ + + Q E + L K + E + L+ E +LQ
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ 1513
Query: 737 SLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLE 796
+S L+ + +L ++ Q+E+EK LQ +AE A E E + LR++
Sbjct: 1514 EISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE-----ASLEHEEGKILRIQ 1568
Query: 797 QEVARQGLEGSLRVAEQAQE----------ALEQQLPTLRHERSQLQEQLAQLSRQLSGR 846
E+ + E ++AE+ +E +E TL E + + +L +++ G
Sbjct: 1569 LELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAI-RLKKKMEGD 1627
Query: 847 EQELEQARREAQRQVEALERAAREKEALAKE-----------HAGLAVQLVAAEREGRTL 895
E+E A R R R + + K+ L QL ER L
Sbjct: 1628 LNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLL 1687
Query: 896 SEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETL-------TGEL 948
E LR E E S +++L R + L + +L+ K+ L GE+
Sbjct: 1688 QAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEM 1747
Query: 949 AGLRQQIIATQEKAS---LDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQ-REKEA 1004
+ Q+ +EKA D +MA++L + E++ A L + E+ ++ LQ R EA
Sbjct: 1748 EDILQEARNAEEKAKKAITDAAMMAEEL-KKEQDTSAHLERMKKNMEQTVKDLQLRLDEA 1806
Query: 1005 AWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQER---DEGLLLAESEKQ 1061
L+ + Q+Q +L+ EL +E+E++ +E + L++ E E +++
Sbjct: 1807 EQLALKGGKKQIQ-KLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRK 1865
Query: 1062 QALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLR 1121
L L++ L +KL +++ KR A+ +EQ + + +L
Sbjct: 1866 NILRLQD-----LVDKLQA----------KVKSYKRQAEEAEEQSNTNLAKFRKLQHELE 1910
Query: 1122 AQREEAAAAHAQEVRRLQEQARDL 1145
E A A +Q V +L+ ++R++
Sbjct: 1911 EAEERADIAESQ-VNKLRVKSREV 1933
Score = 150 bits (380), Expect = 9e-36
Identities = 234/1152 (20%), Positives = 465/1152 (40%), Gaps = 145/1152 (12%)
Query: 905 EKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASL 964
E ++ +++ +LA+ EA+R++LE + LL K L Q + + +
Sbjct: 854 EMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDL--------QLQVQAEAEGLA 905
Query: 965 DKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQ 1024
D E +L++ + + +A ++E ED + + E A R+LE E ++L+ + +
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEV-TERAEDEEEINAELTAKKRKLEDECSELKKDID-DL 963
Query: 1025 EELLARLEAEKEELSEEIAALQQER---DEGLLLAESEKQQALSLKESEKTALSEKLMGT 1081
E LA++E EK ++ L +E DE + EK+ +L+E+ + L + L
Sbjct: 964 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK---ALQEAHQQTLDD-LQAE 1019
Query: 1082 RHSLATIS---LEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRL 1138
+ T++ +++E+Q D + EQ++ LR E A +++
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKK-----------LRMDLERAKRKLEGDLKLA 1068
Query: 1139 QEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEA 1198
QE D+ ++ + ++ ++ L+ + + ++ Q+K++E Q E +E
Sbjct: 1069 QESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128
Query: 1199 GELRRSLGEGAKEREALRRSNEELRSAVKKA---ESERISLKLANEDKEQKLAL-LEEAR 1254
R S + K+R L R EE+ +++A S +I + E + QK+ LEEA
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1188
Query: 1255 TAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGE 1314
A LR ++ S E ++ L+R + L+ E + + E+ +L +
Sbjct: 1189 LQHEATAATLR---KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVS 1245
Query: 1315 RAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEAR 1374
+A+ + L +L + L+ +E Q L Q G +T L+E
Sbjct: 1246 KAKGNLEKMCRTLEDQL----SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKE 1301
Query: 1375 GTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLG 1434
Q + ++E + + E + A A L++ ++ R E +
Sbjct: 1302 ALVSQLSRGKQAFTQQIEELKRQLEE---EIKAKNALAHALQSSRHDCDLLREQYEEEQE 1358
Query: 1435 GLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPA 1494
++ L+R L R + A E L+ +
Sbjct: 1359 S-KAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAA----------- 1406
Query: 1495 TSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRAR 1554
+ EAV + + Q E ++L N A ++ ++ R
Sbjct: 1407 ------EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQ-------R 1453
Query: 1555 QLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATES 1614
K +AE ++ L Q E + + + +LDQ+ TL+R + +
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ 1513
Query: 1615 ELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGL-- 1672
E+ E+I++ +LE K+++++ ++ + E EG++ R +L L
Sbjct: 1514 EISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQ 1573
Query: 1673 --SDREAQAQALQDRVDSLQRQ-VADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVR 1729
S+ + + + +D L+R + E TL + N A+ ++ EG L +
Sbjct: 1574 VKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEI 1633
Query: 1730 GLTEALAQSSASLNSTR-------DKNLHLQKALTACEHDRQVLQERLDAARQALSEARK 1782
L A ++ +L + R D +HL AL + QE L ++ L+ +
Sbjct: 1634 QLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRS--------QEDL---KEQLAMVER 1682
Query: 1783 QSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRL 1842
+++ L +++ LR + E R AE +L E ++ + +NT +KL+ +
Sbjct: 1683 RANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD--- 1739
Query: 1843 LQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDT-VRLSA 1901
+ +Q + + E R E A + D + E+L+ +DT L
Sbjct: 1740 ----ISQMQGEMEDILQEARNAEEKAKKAITDAAMMA--------EELKKEQDTSAHLER 1787
Query: 1902 EKGRLDRTLTGAELELAEAQ--------RQIQQLEAQVVVLEQSHSPAQLEVDAQQQQ-- 1951
K +++T+ +L L EA+ +QIQ+LEA+V LE EV+++Q++
Sbjct: 1788 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEG-------EVESEQKRNA 1840
Query: 1952 ---LELQQEVERLRSAQAQTER-------------TLEARERAHRQRVRGLEEQVSTLKG 1995
L++ R++ QTE L+A+ ++++++ EEQ +T
Sbjct: 1841 EAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLA 1900
Query: 1996 ---QLQQELRRS 2004
+LQ EL +
Sbjct: 1901 KFRKLQHELEEA 1912
Score = 137 bits (345), Expect = 1e-31
Identities = 214/954 (22%), Positives = 391/954 (40%), Gaps = 146/954 (15%)
Query: 1153 LREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSL---GEG- 1208
L ++ E ++ +++ ++ EL +++ K +E +E +E +L+ + EG
Sbjct: 845 LLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904
Query: 1209 --AKER-EALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELR 1265
A+ER + L ++ +L + +K+ + N + K LE+ + + K+ +L
Sbjct: 905 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964
Query: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQG--RLALGERAEKESRRE 1323
L +VE+ + +++ L +M LD +L +E LQ + L + +E +
Sbjct: 965 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1024
Query: 1324 TLG-----LRQRLLKGEASLEV---MRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARG 1375
TL L Q++ E SLE +R +L+ A+RKL EG+ + + ++ +E
Sbjct: 1025 TLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKL---EGDLKLAQESIM-DIEN--- 1077
Query: 1376 TEKQQLDHA--------RGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRR 1427
EKQQLD L+ K+E +A +L ++ + R + LE E+ R
Sbjct: 1078 -EKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRA 1136
Query: 1428 AAEAQLGGLRSALRR-GLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGS 1486
AE Q L L L A + + R+A + L +
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT-------- 1188
Query: 1487 QPPSPGPATSPASPDLDPEAVRGALRE-FLQELRSAQRERDELRTQTSALNRQLAEMEAE 1545
L EA LR+ + + D L+ L ++ +EM+ E
Sbjct: 1189 ---------------LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKME 1233
Query: 1546 RDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATL 1605
D S + KA E+ R+++ +LS EL +EE +R + A ++ T
Sbjct: 1234 IDDLASNVETVSKAKGNLEKMCRTLEDQLS----ELKSKEEEQQRLINDLTAQRGRLQTE 1289
Query: 1606 --ERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLE- 1662
E S Q E E SQ K +A ++E KR+L+E + A + L+ R +
Sbjct: 1290 SGEFSRQLDEKEALVSQLSRGK-QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDL 1348
Query: 1663 ------------GELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVK---AGTLQLT- 1706
ELQR+ L ++ E + D++QR E K A LQ
Sbjct: 1349 LREQYEEEQESKAELQRA-LSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAE 1407
Query: 1707 --VERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTA----CE 1760
VE +N A +E+++ L+++V L + +++A+ + K + K L CE
Sbjct: 1408 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCE 1467
Query: 1761 HDRQVLQERLDAARQ----------ALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEG 1810
L+ AR A E+ Q +L + + L+ E++DL Q E
Sbjct: 1468 ETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1527
Query: 1811 QLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSAL- 1869
++ +L ++ +Q ++ E L L++ L+ G + R +L K EV+R
Sbjct: 1528 RIHELEKIKKQVEQ-EKCELQAA--LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE 1584
Query: 1870 ------RLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQ 1923
+L+++ + + ++ ++RS D +RL K +++ L E++L A R
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL---KKKMEGDLNEMEIQLNHANRM 1641
Query: 1924 IQ----------------QLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQ 1967
Q+ + Q QL + ++ L LQ E+E LR+ Q
Sbjct: 1642 AAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANL-LQAEIEELRATLEQ 1700
Query: 1968 TERT--------LEARERA---HRQRV------RGLEEQVSTLKGQLQQELRRS 2004
TER+ L+A ER H Q + LE +S ++G+++ L+ +
Sbjct: 1701 TERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEA 1754
Score = 105 bits (263), Expect = 3e-22
Identities = 199/973 (20%), Positives = 383/973 (39%), Gaps = 154/973 (15%)
Query: 5 LARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNL-SQPE 63
L + +++ + LE + LE + ++ + D+ + Q +E NL S+ E
Sbjct: 1044 LEQEKKLRMDLERAKRKLEGDLKLAQESI--MDIENEKQQLDEKLKKKEFEISNLQSKIE 1101
Query: 64 SPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALR 123
L + LQ + L++E+ A++ +R +L+ + +SERLE+A
Sbjct: 1102 DEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGG 1161
Query: 124 LEPGELETQEPRGLVRQSVELRRQLQE-------EQASYRRKLQAYQEGQQRQAQLVQRL 176
++E + R Q ++RR L+E A+ R+K Q +QR+
Sbjct: 1162 ATSAQIEMNKKREAEFQ--KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV 1219
Query: 177 QGKILQYK-------------------------KRCSELEQQLLE-RSGELEQQRLRDTE 210
+ K+ + K K C LE QL E +S E EQQRL
Sbjct: 1220 KQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRL---- 1275
Query: 211 HSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKE 270
DL + RL+ E + L QL + A E++++ + + +
Sbjct: 1276 -INDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNA 1334
Query: 271 LEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR 330
L H + R + + + E L R + V++ + E D +Q EL
Sbjct: 1335 LAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEEL-- 1392
Query: 331 TSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQ---AQLEEQLRDKVLREK-------- 379
+EA L+ L+ AE EA K A L+ +L+ ++ D +L +
Sbjct: 1393 -----EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAA 1447
Query: 380 -DLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNL--EKDQVNKDLTEKLEALESLRLQ 436
D Q+ L + T L + E ++L E ++ E L+ LE+L+
Sbjct: 1448 LDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLK-- 1505
Query: 437 EQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPP 496
+ + LQQ + DL + + +E G ++ E+
Sbjct: 1506 -------RENKNLQQEISDLTEQI---AEGGKRIHELEKI-------------------- 1535
Query: 497 RRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQL 556
++ C + +AL + + ++ G+ Q L ++ ++
Sbjct: 1536 ----------KKQVEQEKCE-------LQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1578
Query: 557 SDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREK------SNLAH 610
+E+ +QL+R + +MQ+ DA+ +RS N+ + +K + +
Sbjct: 1579 DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAE-----IRSRNDAIRLKKKMEGDLNEMEI 1633
Query: 611 SLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR-------ELER 663
L A + A E + Q ++ + D QED + A V R E+E
Sbjct: 1634 QLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEE 1693
Query: 664 SHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELS 723
LEQ E R + +EL++ E + Q L K ++ +++ + E+E
Sbjct: 1694 LRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQG---EMEDI 1750
Query: 724 MTKLRAEEASLQDSLSKLSALNESLAQDK---LDLNRLVAQLEEEKSALQGRQRQAEQEA 780
+ + R E + +++ + + E L +++ L R+ +E+ LQ R +AEQ A
Sbjct: 1751 LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLA 1810
Query: 781 TVAREEQ-ERLE--------ELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQ 831
++Q ++LE E+ EQ+ + ++G LR E+ + L Q R +
Sbjct: 1811 LKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKG-LRKHERRVKELTYQTEEDRKNILR 1869
Query: 832 LQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLA------VQL 885
LQ+ + +L ++ +++ E+A ++ + + E E A+E A +A +++
Sbjct: 1870 LQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEE-AEERADIAESQVNKLRV 1928
Query: 886 VAAEREGRTLSEE 898
+ E + +SEE
Sbjct: 1929 KSREVHTKVISEE 1941
Score = 99.8 bits (247), Expect = 2e-20
Identities = 117/534 (21%), Positives = 234/534 (43%), Gaps = 79/534 (14%)
Query: 1512 REFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQ---KAVAESEEARR 1568
+E +++ + +E+++L+ Q A LA+ E D QL+ K V E E
Sbjct: 877 KELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEE 936
Query: 1569 SVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKA 1628
++ L+ + +L + +++ + TL A +E+ ATE++++ E+++ +
Sbjct: 937 EINAELTAKKRKLEDECSELKKDIDDLELTL---AKVEKEKHATENKVKNLTEEMAGLDE 993
Query: 1629 NETKLEGDKRRLKEV-------LDASESRT-------VKLELQRRSLEGELQRSRLGLSD 1674
KL +K+ L+E L A E + +KLE Q LEG L++ + D
Sbjct: 994 TIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMD 1053
Query: 1675 REAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEA 1734
E + L+ G L+L E ++ +E + L +K++
Sbjct: 1054 LERAKRKLE-----------------GDLKLAQE----SIMDIENEKQQLDEKLKKKEFE 1092
Query: 1735 LAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTL 1794
++ + + + + LQK + + + L+E ++A R + ++A KQ S L +++ +
Sbjct: 1093 ISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1152
Query: 1795 RGEV--------ADLELQRVEAEGQLQQLREVLRQRQ-EGEAAALNTVQKLQDERRLLQE 1845
+ A +E+ + + E + Q++R L + + EA A +K D L E
Sbjct: 1153 SERLEEAGGATSAQIEMNK-KREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1211
Query: 1846 RLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVER---------EKLRSHEDT 1896
++ +LQR +LE EK E++ L + + + +E+ +L+S E+
Sbjct: 1212 QIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEE 1271
Query: 1897 VR-----LSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQ 1951
+ L+A++GRL + E E RQ+ + EA V L + +++ ++Q
Sbjct: 1272 QQRLINDLTAQRGRL-------QTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ 1324
Query: 1952 LELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSS 2005
LE E +++ A +R R + EEQ S K +LQ+ L +++
Sbjct: 1325 LE-----EEIKAKNALAHALQSSRHDCDLLREQYEEEQES--KAELQRALSKAN 1371
Score = 73.6 bits (179), Expect = 2e-12
Identities = 80/361 (22%), Positives = 165/361 (45%), Gaps = 26/361 (7%)
Query: 1639 RLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEV 1698
++K +L ++E+ E + +++ E Q+ + L+ EA+ + L++++ +L ++ D
Sbjct: 841 KIKPLLKSAET-----EKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKND--- 892
Query: 1699 KAGTLQLTVERLNGALAKVEES-EGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALT 1757
LQL V+ LA EE + ++ K++ L + + + + N L
Sbjct: 893 ----LQLQVQAEAEGLADAEERCDQLIKTKIQ-LEAKIKEVTERAEDEEEINAELTAKKR 947
Query: 1758 ACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLRE 1817
E + L++ +D L++ K+ + +V+ L E+A L+ + + + L+E
Sbjct: 948 KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1007
Query: 1818 VLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVA 1877
+Q + A + V L + L++++ L+ +L Q + + ++ER+ +LE D
Sbjct: 1008 AHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1067
Query: 1878 LRRTLDKVEREKLRSHEDTVRLSAEKGRL-----DRTLTGAELE--LAEAQRQIQQLEAQ 1930
+ ++ +E EK + E + E L D G +L+ + E Q +I++LE +
Sbjct: 1068 AQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEE 1127
Query: 1931 VVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLE---ARERAHRQRVRGLE 1987
+ + S A+ E EL++ ERL A T +E RE ++ R LE
Sbjct: 1128 IEA--ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1185
Query: 1988 E 1988
E
Sbjct: 1186 E 1186
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.124 0.312
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,579,504
Number of Sequences: 37866
Number of extensions: 3164531
Number of successful extensions: 103314
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 982
Number of HSP's successfully gapped in prelim test: 1908
Number of HSP's that attempted gapping in prelim test: 23652
Number of HSP's gapped (non-prelim): 29520
length of query: 2017
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1900
effective length of database: 13,817,196
effective search space: 26252672400
effective search space used: 26252672400
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.