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Search of human proteins with 153266822
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
(512 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 1037 0.0
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 747 0.0
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 734 0.0
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 676 0.0
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 665 0.0
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 660 0.0
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 650 0.0
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 464 e-131
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 458 e-129
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 333 2e-91
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 325 8e-89
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 269 5e-72
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 261 1e-69
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 251 8e-67
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 223 4e-58
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 206 4e-53
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 162 7e-40
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 159 4e-39
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 159 4e-39
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 159 4e-39
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 156 5e-38
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 156 5e-38
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 156 5e-38
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 148 1e-35
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 148 1e-35
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 141 1e-33
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 141 1e-33
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 141 1e-33
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 141 1e-33
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens] 141 1e-33
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 1037 bits (2682), Expect = 0.0
Identities = 512/512 (100%), Positives = 512/512 (100%)
Query: 1 MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI 60
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
Sbjct: 1 MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI 60
Query: 61 CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM 120
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
Sbjct: 61 CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM 120
Query: 121 DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW 180
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
Sbjct: 121 DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW 180
Query: 181 NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV 240
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
Sbjct: 181 NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV 240
Query: 241 GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE 300
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
Sbjct: 241 GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE 300
Query: 301 CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK 360
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
Sbjct: 301 CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK 360
Query: 361 QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL 420
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
Sbjct: 361 QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL 420
Query: 421 KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF 480
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
Sbjct: 421 KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF 480
Query: 481 KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP 512
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP
Sbjct: 481 KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP 512
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 747 bits (1928), Expect = 0.0
Identities = 354/492 (71%), Positives = 424/492 (86%)
Query: 20 LPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQ 79
LP P NLE+K+TKIFINNEW S+SG+ F NP+T EQ+CEV+E DK D+DKAV+AA+
Sbjct: 26 LPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAAR 85
Query: 80 VAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIR 139
+AF GS WRR+DA RGRLL +LADLVERDRA LA +E+++ GKPFL AF++DL+G I+
Sbjct: 86 LAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIK 145
Query: 140 TLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGN 199
T RY+AGWADKI G TIP D + FTRHEPIGVCG I PWNFPLLM WK+APALCCGN
Sbjct: 146 TFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGN 205
Query: 200 TMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGST 259
T+V+KPAEQTPL+ALY+G+LIKEAGFPPGV+NI+PG+GPT GAAI+SH I+KIAFTGST
Sbjct: 206 TVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGST 265
Query: 260 EVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASR 319
EVGKL++EAA RSNLKRVTLELGGK+P I+ ADADLD AVE AHQGVFFNQGQCCTA SR
Sbjct: 266 EVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSR 325
Query: 320 VFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKL 379
+FVEE +Y EFVRRSVE AK+R VG PFD TEQGPQID+KQ++KILELI+SG EGAKL
Sbjct: 326 IFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKL 385
Query: 380 ECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGL 439
ECGG + KG FI+PTVFS VTD+MRIAKEEIFGPVQ IL+FK+++EVI+RAN++D+GL
Sbjct: 386 ECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGL 445
Query: 440 TAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTE 499
AAVFT +++KAL ++SA+++GTVWINCYNAL AQ+PFGGFKMSGNGRE+GE+ L EY+E
Sbjct: 446 VAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSE 505
Query: 500 VKTVTIKLGDKN 511
VKTVT+K+ KN
Sbjct: 506 VKTVTVKIPQKN 517
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 734 bits (1896), Expect = 0.0
Identities = 350/494 (70%), Positives = 419/494 (84%)
Query: 18 PALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEA 77
P LP + +L++++TKIFINNEWH+S SGKKF NP+T E++C+VEEGDK DVDKAV+A
Sbjct: 7 PDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKA 66
Query: 78 AQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGC 137
A+ AFQ GSPWR +DA RGRLL++LADL+ERDR LA +E+M+ GK + +A+ DL GC
Sbjct: 67 ARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGC 126
Query: 138 IRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCC 197
I+TLRY AGWADKIQG+TIP D N +TRHEPIGVCG I PWNFPL+ML+WK+ PAL C
Sbjct: 127 IKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSC 186
Query: 198 GNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTG 257
GNT+V+KPAEQTPLTAL++ SLIKEAGFPPGVVNIVPG+GPT GAAISSH I+K+AFTG
Sbjct: 187 GNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTG 246
Query: 258 STEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAA 317
STEVGKL+KEAA +SNLKRVTLELGGK+PCIV ADADLD AVE AH GVF++QGQCC AA
Sbjct: 247 STEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAA 306
Query: 318 SRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGA 377
SR+FVEE +Y EFVRRSVE AKK +G+P QGPQID++Q+DKIL+LIESGKKEGA
Sbjct: 307 SRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGA 366
Query: 378 KLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDY 437
KLECGG +KG F++PTVFS VTD MRIAKEEIFGPVQ I+KFKS+++VIKRAN+T Y
Sbjct: 367 KLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFY 426
Query: 438 GLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEY 497
GL+A VFTK++DKA+ ++SAL++GTVW+NCY + AQ PFGGFKMSGNGRELGEY EY
Sbjct: 427 GLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEY 486
Query: 498 TEVKTVTIKLGDKN 511
TEVKTVT+K+ KN
Sbjct: 487 TEVKTVTVKISQKN 500
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 676 bits (1744), Expect = 0.0
Identities = 326/493 (66%), Positives = 394/493 (79%)
Query: 19 ALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAA 78
A+P P + EV +IFINNEWH++ S K F T NPST E IC+V EGDK DVDKAV+AA
Sbjct: 24 AVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAA 83
Query: 79 QVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCI 138
+ AFQ GSPWRR+DA RGRLL++LADL+ERDR LAALET+D GKP++ ++ +DL+ +
Sbjct: 84 RAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVL 143
Query: 139 RTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCG 198
+ LRY+AGWADK GKTIP D + +TRHEP+GVCG I PWNFPLLM WKL PAL G
Sbjct: 144 KCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATG 203
Query: 199 NTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGS 258
N +V+K AEQTPLTALY+ +LIKEAGFPPGVVNIVPGFGPT GAAI+SH ++K+AFTGS
Sbjct: 204 NVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGS 263
Query: 259 TEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAAS 318
TE+G++++ AA SNLKRVTLELGGK+P I+ +DAD+D AVE AH +FFNQGQCC A S
Sbjct: 264 TEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGS 323
Query: 319 RVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAK 378
R FV+E +Y EFV RSV AK R VG+PFD KTEQGPQ+D+ QF KIL I +GK+EGAK
Sbjct: 324 RTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAK 383
Query: 379 LECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYG 438
L CGG D+G FI+PTVF +V D M IAKEEIFGPV ILKFK+IEEV+ RAN++ YG
Sbjct: 384 LLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYG 443
Query: 439 LTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYT 498
L AAVFTK+LDKA L+ AL++GTVW+NCY+ AQ+PFGG+KMSG+GRELGEY L YT
Sbjct: 444 LAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYT 503
Query: 499 EVKTVTIKLGDKN 511
EVKTVT+K+ KN
Sbjct: 504 EVKTVTVKVPQKN 516
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 665 bits (1716), Expect = 0.0
Identities = 324/492 (65%), Positives = 389/492 (79%), Gaps = 38/492 (7%)
Query: 20 LPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQ 79
LP P NLE+K+TKIFINNEW S+SG+ F NP+T EQ+CEV+E DK D+DKAV+AA+
Sbjct: 26 LPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAAR 85
Query: 80 VAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIR 139
+AF GS WRR+DA RGRLL +LADLVERDRA LA +E+++ GKPFL AF++DL+G I+
Sbjct: 86 LAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIK 145
Query: 140 TLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGN 199
T RY+AGWADKI G TIP D + FTRHEPIGVCG I PWNFPLLM WK+APALCCGN
Sbjct: 146 TFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGN 205
Query: 200 TMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGST 259
T+V+KPAEQTPL+ALY+G+LIKE
Sbjct: 206 TVVIKPAEQTPLSALYMGALIKE------------------------------------- 228
Query: 260 EVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASR 319
VGKL++EAA RSNLKRVTLELGGK+P I+ ADADLD AVE AHQGVFFNQGQCCTA SR
Sbjct: 229 -VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSR 287
Query: 320 VFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKL 379
+FVEE +Y EFVRRSVE AK+R VG PFD TEQGPQID+KQ++KILELI+SG EGAKL
Sbjct: 288 IFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKL 347
Query: 380 ECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGL 439
ECGG + KG FI+PTVFS VTD+MRIAKEEIFGPVQ IL+FK+++EVI+RAN++D+GL
Sbjct: 348 ECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGL 407
Query: 440 TAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTE 499
AAVFT +++KAL ++SA+++GTVWINCYNAL AQ+PFGGFKMSGNGRE+GE+ L EY+E
Sbjct: 408 VAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSE 467
Query: 500 VKTVTIKLGDKN 511
VKTVT+K+ KN
Sbjct: 468 VKTVTVKIPQKN 479
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 660 bits (1704), Expect = 0.0
Identities = 317/493 (64%), Positives = 391/493 (79%)
Query: 19 ALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAA 78
ALP PI N ++ + ++FINNEW ++ S K F T NP+T E I V EGD+ DVD+AV+AA
Sbjct: 24 ALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAA 83
Query: 79 QVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCI 138
+ AF+ GSPWRR+DA RGRLL++LADLVERDR LA+LET+D GKPF ++ +DL+ I
Sbjct: 84 REAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVI 143
Query: 139 RTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCG 198
+ RYFAGWADK GKTIP D CFTRHEP+GVCG I PWNFPL+M WKLAPAL G
Sbjct: 144 KVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATG 203
Query: 199 NTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGS 258
NT+V+K AEQTPL+ALYL SLIKEAGFPPGVVNI+ G+GPT GAAI+ H ++K+AFTGS
Sbjct: 204 NTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGS 263
Query: 259 TEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAAS 318
TEVG L+++AA SNLKRVTLELGGK+P IV ADAD++ AVE H+ +FFN GQCC A S
Sbjct: 264 TEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGS 323
Query: 319 RVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAK 378
R FVEE +Y+EF+ R+VE AK+R VG+PF++ T+QGPQ+D++QF+++L I+ G+KEGAK
Sbjct: 324 RTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAK 383
Query: 379 LECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYG 438
L CGG ++G FIKPTVF V D+MRIAKEEIFGPVQP+ KFK IEEV++RAN+T YG
Sbjct: 384 LLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYG 443
Query: 439 LTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYT 498
L AAVFT++LDKA+ AL++GTVW+N YN + PFGGFK SGNGRELGE L YT
Sbjct: 444 LAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYT 503
Query: 499 EVKTVTIKLGDKN 511
EVKTVTIK+ KN
Sbjct: 504 EVKTVTIKVPQKN 516
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 650 bits (1676), Expect = 0.0
Identities = 309/421 (73%), Positives = 368/421 (87%)
Query: 91 LDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADK 150
+DA RGRLL +LADLVERDRA LA +E+++ GKPFL AF++DL+G I+T RY+AGWADK
Sbjct: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
Query: 151 IQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTP 210
I G TIP D + FTRHEPIGVCG I PWNFPLLM WK+APALCCGNT+V+KPAEQTP
Sbjct: 61 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 120
Query: 211 LTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAAS 270
L+ALY+G+LIKEAGFPPGV+NI+PG+GPT GAAI+SH I+KIAFTGSTEVGKL++EAA
Sbjct: 121 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 180
Query: 271 RSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEF 330
RSNLKRVTLELGGK+P I+ ADADLD AVE AHQGVFFNQGQCCTA SR+FVEE +Y EF
Sbjct: 181 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 240
Query: 331 VRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKG 390
VRRSVE AK+R VG PFD TEQGPQID+KQ++KILELI+SG EGAKLECGG + KG
Sbjct: 241 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 300
Query: 391 LFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDK 450
FI+PTVFS VTD+MRIAKEEIFGPVQ IL+FK+++EVI+RAN++D+GL AAVFT +++K
Sbjct: 301 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 360
Query: 451 ALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGDK 510
AL ++SA+++GTVWINCYNAL AQ+PFGGFKMSGNGRE+GE+ L EY+EVKTVT+K+ K
Sbjct: 361 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 420
Query: 511 N 511
N
Sbjct: 421 N 421
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 464 bits (1195), Expect = e-131
Identities = 236/494 (47%), Positives = 330/494 (66%), Gaps = 8/494 (1%)
Query: 20 LPRPIRNLEVKFT-KIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAA 78
+ + + + VK + FIN ++ ++ GK + T NP+ IC+V DVDKAV AA
Sbjct: 430 ISKEVNEIMVKMPYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAA 489
Query: 79 QVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCI 138
+ AF+ G W R++A RGRL+++LADL+E ++ LA +E +D+G + A + +
Sbjct: 490 KDAFENGE-WGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSV 548
Query: 139 RTLRYFAGWADKIQGKTIPTD----DNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPA 194
+T RYFAGW DKIQG TIP + + + FT+ EP+GVC I PWN+PL+ML WK A
Sbjct: 549 QTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAAC 608
Query: 195 LCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIA 254
L GNT+VLKPA+ TPLTAL L +AGFP GV+NI+PG G G +S HP I K+
Sbjct: 609 LAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLG 668
Query: 255 FTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCC 314
FTGST +GK + ++ + SNLK+V+LELGGK+P I+ D +LD AV VFFN+G+ C
Sbjct: 669 FTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENC 728
Query: 315 TAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKK 374
AA R+FVEE ++ EFV R VE KK +GDP D T+ GPQ + +K+L+ E+G K
Sbjct: 729 IAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVK 788
Query: 375 EGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKS--IEEVIKRA 432
EGA L GG ++ G F++PTVF++V D M +AKEE FGP+ I KF++ I+ V++RA
Sbjct: 789 EGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRA 848
Query: 433 NSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEY 492
NST+YGL + VFT++++KA+ ++ LE+GTV+IN YN APFGG K SG G++LGE
Sbjct: 849 NSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEE 908
Query: 493 ALAEYTEVKTVTIK 506
AL EY + KTVT++
Sbjct: 909 ALNEYLKTKTVTLE 922
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 458 bits (1178), Expect = e-129
Identities = 233/480 (48%), Positives = 320/480 (66%), Gaps = 7/480 (1%)
Query: 33 KIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLD 92
++FI E+ +++ K T NP+ IC+V DVDKAV AA+ AF+ G W ++
Sbjct: 423 QLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGR-WGKIS 481
Query: 93 ALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQ 152
A RGRL+++LADL+E+ + LA +E +D G + A + I+T RYFAGW DKIQ
Sbjct: 482 ARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQ 541
Query: 153 GKTIPTD----DNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQ 208
G TIP + + + TR EP+GVCG I PWN+PL+ML WK A L GNT+V+KPA+
Sbjct: 542 GSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQV 601
Query: 209 TPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEA 268
TPLTAL L +AG P GVVN++PG G VG +S HP + KI FTGSTEVGK + ++
Sbjct: 602 TPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKS 661
Query: 269 ASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYS 328
+ SN+K+V+LELGGK+P I+ AD DL+ AV+ VFFN+G+ C AA R+FVE+ ++
Sbjct: 662 CAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHD 721
Query: 329 EFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMED 388
EFVRR VE +K VG+P D T+ GPQ K++E + G KEGA L CGG+ +
Sbjct: 722 EFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPR 781
Query: 389 KGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFK--SIEEVIKRANSTDYGLTAAVFTK 446
G F +PTVF++V D+M IAKEE FGPV I +F ++ V+ RAN+T++GL + VFT+
Sbjct: 782 PGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTR 841
Query: 447 NLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIK 506
+++KAL ++ L++GTV++N YN APFGGFK SG G++LGE AL EY VKTVT +
Sbjct: 842 DINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTFE 901
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 333 bits (854), Expect = 2e-91
Identities = 182/462 (39%), Positives = 266/462 (57%), Gaps = 12/462 (2%)
Query: 53 NPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRA 112
+PST E C V K +++ AV+AA+ AF W R R+L+Q+ADL+E+
Sbjct: 29 DPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS---WSSRSPQERSRVLNQVADLLEQSLE 85
Query: 113 TLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDD-NVVCFTRHEPI 171
A E+ D GK A +D+ ++ R+FA + + D + +T P+
Sbjct: 86 EFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPV 145
Query: 172 GVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVN 231
GV G I+PWN PL +L WK+APA+ GNT++ KP+E T +TA L L+ +AG PPGVVN
Sbjct: 146 GVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVN 205
Query: 232 IVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCA 291
IV G GP VG A+ SHP++ I+FTGS + + + S + K+++LELGGKNP I+
Sbjct: 206 IVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQ-LSAPHCKKLSLELGGKNPAIIFE 264
Query: 292 DADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKT 351
DA+LD + + F NQG+ C SR+FV++ +YSEF++R VE +K VG P D
Sbjct: 265 DANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPLV 324
Query: 352 EQGPQIDQKQFDKILELIESGKKEGAKLECGGS-------AMEDKGLFIKPTVFSEVTDN 404
G I + +K+ ++ EGA++ CG A G F+ PTV +++ D
Sbjct: 325 SIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDE 384
Query: 405 MRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVW 464
EEIFGPV ++ F S EEVI+RAN+ YGL A V++ N+ + ++A L+SG VW
Sbjct: 385 SCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVW 444
Query: 465 INCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIK 506
NC+ PFGG K SG GRE + + +TE+KT+T+K
Sbjct: 445 TNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 325 bits (832), Expect = 8e-89
Identities = 173/462 (37%), Positives = 270/462 (58%), Gaps = 12/462 (2%)
Query: 54 PSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRAT 113
P+T I + +V+ AV+ A+ AF+ W + + R R+L + A ++
Sbjct: 58 PATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSGMERCRILLEAARIIREREDE 114
Query: 114 LAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGV 173
+A +E ++ GK A +D++ + L Y+AG A + G+ I +TR EP+GV
Sbjct: 115 IATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGV 173
Query: 174 CGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIV 233
C I WN+P + WK APAL CGN MV KP+ TP++AL L + EAG PPG+ N+V
Sbjct: 174 CVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVV 233
Query: 234 PGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADA 293
G G G + HP + K++FTGS G + E +++ +K VTLELGGK+P I+ +D
Sbjct: 234 QG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG-IKPVTLELGGKSPLIIFSDC 291
Query: 294 DLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQ 353
D++ AV+ A F QGQ C +RVFV++++ +F V+ ++ +GDP T
Sbjct: 292 DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRM 351
Query: 354 GPQIDQKQFDKILELIESGKKEGAKLECGGSAM--EDK----GLFIKPTVFSEVTDNMRI 407
GP I++ +++L ++ K++GAK+ CGG ED G +++P V + D+M
Sbjct: 352 GPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTC 411
Query: 408 AKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINC 467
KEEIFGPV IL F + EV++RAN T +GL A VFT+++ +A ++ + L++GT +IN
Sbjct: 412 VKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN 471
Query: 468 YNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGD 509
YN + PFGG+K SG GRE G + Y+++KTV +++GD
Sbjct: 472 YNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGD 513
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 269 bits (687), Expect = 5e-72
Identities = 166/462 (35%), Positives = 240/462 (51%), Gaps = 66/462 (14%)
Query: 53 NPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRA 112
+PST E C V K +++ AV+AA+ AF W R R+L+Q+ADL+E+
Sbjct: 29 DPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS---WSSRSPQERSRVLNQVADLLEQSLE 85
Query: 113 TLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDD-NVVCFTRHEPI 171
A E+ D GK A +D+ ++ R+FA + + D + +T P+
Sbjct: 86 EFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPV 145
Query: 172 GVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVN 231
GV G I+PWN PL +L WK+APA+ GNT++ KP+E T +TA L L+ +AG PPGVVN
Sbjct: 146 GVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVN 205
Query: 232 IVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCA 291
IV G GP VG A+ SHP++ I+FTGS + + + S + K+++LELGGKNP I+
Sbjct: 206 IVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQ-LSAPHCKKLSLELGGKNPAIIFE 264
Query: 292 DADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKT 351
DA+LD +C A R QV S +V+R++
Sbjct: 265 DANLD---------------ECIPATVRSSFANQVRS-YVKRAL---------------- 292
Query: 352 EQGPQIDQKQFDKILELIESGKKEGAKLECGGS-------AMEDKGLFIKPTVFSEVTDN 404
EGA++ CG A G F+ PTV +++ D
Sbjct: 293 ----------------------AEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDE 330
Query: 405 MRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVW 464
EEIFGPV ++ F S EEVI+RAN+ YGL A V++ N+ + ++A L+SG VW
Sbjct: 331 SCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVW 390
Query: 465 INCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIK 506
NC+ PFGG K SG GRE + + +TE+KT+T+K
Sbjct: 391 TNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 432
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 261 bits (666), Expect = 1e-69
Identities = 170/478 (35%), Positives = 253/478 (52%), Gaps = 14/478 (2%)
Query: 32 TKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRL 91
T F+ W + + F +P++ + V + + AV AA AF R WR +
Sbjct: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR---WREV 115
Query: 92 DALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKI 151
A R LL + +L+ +++ LA + T ++GKP A L L +F+ A ++
Sbjct: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEARRV 174
Query: 152 QGKTI--PTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQT 209
G I P D + +PIGV ITPWNFP M+ K+ AL G T+V+KPAE T
Sbjct: 175 YGDIIHTPAKDRRALVLK-QPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233
Query: 210 PLTALYLGSLIKEAGFPPGVVNIVPGF---GPTVGAAISSHPQINKIAFTGSTEVGKLVK 266
P +AL L L +AG P GV N++P VG AI + P ++KI+FTGST GK++
Sbjct: 234 PFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILL 293
Query: 267 EAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQV 326
A+ S +KRV++ELGG P IV A++D AV A F N GQ C +++ V+ +
Sbjct: 294 HHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGI 352
Query: 327 YSEFVRRSVEYAKKR-PVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSA 385
+ FV+ E KK VG+ F+ T QGP I++K +K+ + + +GA + GG
Sbjct: 353 HDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR 412
Query: 386 MEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFT 445
+ F +PT+ VT +M EE FGP+ P++KF + EE I AN+ D GL ++
Sbjct: 413 HQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYS 472
Query: 446 KNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTV 503
++ + ++A LE G V +N + PFGG K SG GRE +Y + EY E+K V
Sbjct: 473 QDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 251 bits (642), Expect = 8e-67
Identities = 170/491 (34%), Positives = 253/491 (51%), Gaps = 27/491 (5%)
Query: 32 TKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRL 91
T F+ W + + F +P++ + V + + AV AA AF R WR +
Sbjct: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR---WREV 115
Query: 92 DALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKI 151
A R LL + +L+ +++ LA + T ++GKP A L L +F+ A ++
Sbjct: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEARRV 174
Query: 152 QGKTI--PTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQT 209
G I P D + +PIGV ITPWNFP M+ K+ AL G T+V+KPAE T
Sbjct: 175 YGDIIHTPAKDRRALVLK-QPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233
Query: 210 PLTALYLGS-------------LIKEAGFPPGVVNIVPGF---GPTVGAAISSHPQINKI 253
P +AL L L +AG P GV N++P VG AI + P ++KI
Sbjct: 234 PFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKI 293
Query: 254 AFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQC 313
+FTGST GK++ A+ S +KRV++ELGG P IV A++D AV A F N GQ
Sbjct: 294 SFTGSTTTGKILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQT 352
Query: 314 CTAASRVFVEEQVYSEFVRRSVEYAKKR-PVGDPFDVKTEQGPQIDQKQFDKILELIESG 372
C +++ V+ ++ FV+ E KK VG+ F+ T QGP I++K +K+ + +
Sbjct: 353 CVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDA 412
Query: 373 KKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRA 432
+GA + GG + F +PT+ VT +M EE FGP+ P++KF + EE I A
Sbjct: 413 VSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIA 472
Query: 433 NSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEY 492
N+ D GL ++++ + ++A LE G V +N + PFGG K SG GRE +Y
Sbjct: 473 NAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKY 532
Query: 493 ALAEYTEVKTV 503
+ EY E+K V
Sbjct: 533 GIDEYLELKYV 543
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 223 bits (567), Expect = 4e-58
Identities = 151/486 (31%), Positives = 244/486 (50%), Gaps = 19/486 (3%)
Query: 29 VKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPW 88
V K+FI ++ ESKS K NP+T E I V + K ++D A+ + + AF W
Sbjct: 37 VPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPA---W 93
Query: 89 RRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWA 148
LSR ++L + L++ + +A L T++ GK A G ++ + +
Sbjct: 94 ADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRG-LQVVEHACSVT 152
Query: 149 DKIQGKTIPT-DDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAE 207
+ G+T+P+ ++ ++ P+GVC I P+NFP ++ +W A+ CGNT ++KP+E
Sbjct: 153 SLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSE 212
Query: 208 QTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKE 267
+ P + L L++++G P G +NI+ G V I HP I I+F GS + G+ + E
Sbjct: 213 RVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVN-FICDHPDIKAISFVGSNKAGEYIFE 271
Query: 268 AASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVY 327
SR KRV +G KN +V DA+ + + F GQ C A S + +
Sbjct: 272 RGSRHG-KRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEA- 329
Query: 328 SEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAME 387
+++ VE+AK V + GP I + +++ LI+SG KEGA + G ++
Sbjct: 330 KKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIK 389
Query: 388 DKGL----FIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAV 443
KG F+ PT+ S V NM KEEIFGPV +L+ ++++E I+ N+ YG A+
Sbjct: 390 VKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAI 449
Query: 444 FTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMS-----GNGRELGEYALAEYT 498
FT N A K A ++ G V +N + P F S G+ G+ + YT
Sbjct: 450 FTTNGATARKYAHLVDVGQVGVNV--PIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYT 507
Query: 499 EVKTVT 504
++KT+T
Sbjct: 508 QLKTIT 513
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 206 bits (524), Expect = 4e-53
Identities = 144/487 (29%), Positives = 230/487 (47%), Gaps = 22/487 (4%)
Query: 37 NNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSR 96
N W G+ T P+ E I V + D ++ V+ A+ A++ W + A R
Sbjct: 56 NGSW--GGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKI---WADIPAPKR 110
Query: 97 GRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTI 156
G ++ Q+ D + L +L +++ GK + +++ + Y G + I G +
Sbjct: 111 GEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVG-EVQEYVDICDYAVGLSRMIGGPIL 169
Query: 157 PTD-DNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALY 215
P++ + P+G+ G IT +NFP+ + W A A+ CGN + K A T L ++
Sbjct: 170 PSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVA 229
Query: 216 LGSLIK---EAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGK----LVKEA 268
+ +I E PG + + G +G A++ ++N ++FTGST+VGK +V+E
Sbjct: 230 VTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQER 289
Query: 269 ASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYS 328
RS LELGG N I DADL L V A GQ CT A R+F+ E ++
Sbjct: 290 FGRS-----LLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHD 344
Query: 329 EFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMED 388
E V R + + VG+P+D GP ++ L +E KKEG + GG M+
Sbjct: 345 EVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDR 404
Query: 389 KGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNL 448
G +++PT+ + + + IA E F P+ + KFK+ EEV N GL++++FTK+L
Sbjct: 405 PGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDL 464
Query: 449 DKALKL--ASALESGTVWINC-YNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTI 505
+ + + G V +N + FGG K +G GRE G A +Y T TI
Sbjct: 465 GRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
Query: 506 KLGDKNP 512
P
Sbjct: 525 NYSKDLP 531
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 162 bits (410), Expect = 7e-40
Identities = 130/465 (27%), Positives = 218/465 (46%), Gaps = 25/465 (5%)
Query: 35 FINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDAL 94
++N +W + + +P T E + + DV AVEAA++AF+ W +
Sbjct: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKG---WSAHPGV 99
Query: 95 SRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGK 154
R + L +LA+++++ + L LE++ TG+ D++ + L Y A IQ
Sbjct: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA-----IQAS 154
Query: 155 TIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMV--LKPAEQTPLT 212
T EP+GV G I P F L ++W++ PAL G T+V + PA PL
Sbjct: 155 T-----QEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLL 209
Query: 213 ALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRS 272
L L E G PG++N++ G V ++S P I K+AF G+ E G+ ++ + +
Sbjct: 210 ---LAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSLA-G 264
Query: 273 NLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVR 332
+ L LG ++ ++ AD+D AVE + ++G R+ ++E V+ E +R
Sbjct: 265 ECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGP---GGLRLLIQESVWDEAMR 321
Query: 333 RSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLF 392
R E + G D + G + D + + + +GA++ G ++ F
Sbjct: 322 RLQERMGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPSERP-F 379
Query: 393 IKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKAL 452
PT+ S + A+ E+ PV F++ +E + AN T G +A+V+++ L +AL
Sbjct: 380 YPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQAL 439
Query: 453 KLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEY 497
+L L+ GTVWIN + P GG K SG G L EY
Sbjct: 440 ELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEY 484
Score = 80.9 bits (198), Expect = 3e-15
Identities = 74/223 (33%), Positives = 105/223 (47%), Gaps = 13/223 (5%)
Query: 63 VEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDT 122
V EG D+ AVEAA AF W +R LL LA +ER ++TLA+ ++
Sbjct: 558 VAEGGAKDIRGAVEAAHQAFPG---WAGQSPGARAALLWALAAALERRKSTLAS--RLER 612
Query: 123 GKPFLHAFFIDLEGCIRTLRYFAGWADKIQ--GKTIPTDDNVVCFTR-HEPIGVCGAITP 179
L A ++E R LR W ++Q G T+ R EP+GV + P
Sbjct: 613 QGAELKAAEAEVELSARRLR---AWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCP 669
Query: 180 WNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPT 239
+PLL V LAPAL GNT+V+ P+ PL AL + + FP G+ N+V G
Sbjct: 670 DEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDRDH 728
Query: 240 VGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELG 282
+ ++ H + + + GS + + V E AS NLK V G
Sbjct: 729 LTRCLALHQDVQAMWYFGSAQGSQFV-EWASAGNLKPVWASRG 770
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 159 bits (403), Expect = 4e-39
Identities = 120/442 (27%), Positives = 206/442 (46%), Gaps = 20/442 (4%)
Query: 71 VDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAF 130
+ +AV+ A+ AF G R R + L L L++ L D K +A+
Sbjct: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 131 FIDLEGCIRTLRYFAG----WADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLM 186
+ ++ + + Y WA + P + EP+GV I WN+P +
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 187 LVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISS 246
+ + A+ GN++VLKP+E + A L ++I + + ++ G P +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179
Query: 247 HPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGV 306
+ + I +TGST VGK++ AA++ +L VTLELGGK+PC V + DLD+A G
Sbjct: 180 --RFDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
Query: 307 FFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKIL 366
F N GQ C A + + + ++ V + ++ + K G+ + G I + F +++
Sbjct: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
Query: 367 ELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIE 426
LI EG K+ GG+ + +I PT+ ++V + +EEIFGPV PI+ +S+E
Sbjct: 296 GLI-----EGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349
Query: 427 EVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWIN--CYNALYAQAPFGGFKMSG 484
E I+ N + L +F+ N K+ + SG V N + PFGG SG
Sbjct: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSG 409
Query: 485 NGRELGEYALAEYTEVKTVTIK 506
G G+ + ++ ++ ++
Sbjct: 410 MGSYHGKKSFETFSHRRSCLVR 431
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 159 bits (403), Expect = 4e-39
Identities = 120/442 (27%), Positives = 206/442 (46%), Gaps = 20/442 (4%)
Query: 71 VDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAF 130
+ +AV+ A+ AF G R R + L L L++ L D K +A+
Sbjct: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 131 FIDLEGCIRTLRYFAG----WADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLM 186
+ ++ + + Y WA + P + EP+GV I WN+P +
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 187 LVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISS 246
+ + A+ GN++VLKP+E + A L ++I + + ++ G P +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179
Query: 247 HPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGV 306
+ + I +TGST VGK++ AA++ +L VTLELGGK+PC V + DLD+A G
Sbjct: 180 --RFDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
Query: 307 FFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKIL 366
F N GQ C A + + + ++ V + ++ + K G+ + G I + F +++
Sbjct: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
Query: 367 ELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIE 426
LI EG K+ GG+ + +I PT+ ++V + +EEIFGPV PI+ +S+E
Sbjct: 296 GLI-----EGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349
Query: 427 EVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWIN--CYNALYAQAPFGGFKMSG 484
E I+ N + L +F+ N K+ + SG V N + PFGG SG
Sbjct: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSG 409
Query: 485 NGRELGEYALAEYTEVKTVTIK 506
G G+ + ++ ++ ++
Sbjct: 410 MGSYHGKKSFETFSHRRSCLVR 431
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 159 bits (403), Expect = 4e-39
Identities = 120/442 (27%), Positives = 206/442 (46%), Gaps = 20/442 (4%)
Query: 71 VDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAF 130
+ +AV+ A+ AF G R R + L L L++ L D K +A+
Sbjct: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 131 FIDLEGCIRTLRYFAG----WADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLM 186
+ ++ + + Y WA + P + EP+GV I WN+P +
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 187 LVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISS 246
+ + A+ GN++VLKP+E + A L ++I + + ++ G P +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179
Query: 247 HPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGV 306
+ + I +TGST VGK++ AA++ +L VTLELGGK+PC V + DLD+A G
Sbjct: 180 --RFDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
Query: 307 FFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKIL 366
F N GQ C A + + + ++ V + ++ + K G+ + G I + F +++
Sbjct: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
Query: 367 ELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIE 426
LI EG K+ GG+ + +I PT+ ++V + +EEIFGPV PI+ +S+E
Sbjct: 296 GLI-----EGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349
Query: 427 EVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWIN--CYNALYAQAPFGGFKMSG 484
E I+ N + L +F+ N K+ + SG V N + PFGG SG
Sbjct: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSG 409
Query: 485 NGRELGEYALAEYTEVKTVTIK 506
G G+ + ++ ++ ++
Sbjct: 410 MGSYHGKKSFETFSHRRSCLVR 431
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 156 bits (394), Expect = 5e-38
Identities = 137/467 (29%), Positives = 217/467 (46%), Gaps = 32/467 (6%)
Query: 67 DKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDR-ATLAALETMDTGKP 125
DK ++KA+EAA A + W R ++ + AD++ R A + A + GK
Sbjct: 98 DKSLLNKAIEAALAARKE---WDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKT 154
Query: 126 FLHAFFIDLEGCIRTLRYFAGWADKIQGK---TIPTDDNVVCFTRHEPIGVCGAITPWNF 182
+ A I R+ A +A +++G+ ++P N + E G AI+P+NF
Sbjct: 155 VIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--GFVAAISPFNF 212
Query: 183 PLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGA 242
+ APAL GN ++ KP++ L + + +++EAG PP ++ VP GP G
Sbjct: 213 TAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGD 271
Query: 243 AISSHPQINKIAFTGSTEVGK-LVKEAASR----SNLKRVTLELGGKNPCIVCADADLDL 297
++S + I FTGS K L K+ A R+ E GGKN V AD++
Sbjct: 272 TVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVES 331
Query: 298 AVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPF-DVKTEQGPQ 356
V + F GQ C+A SR++V ++ + R +E + VGDP D T
Sbjct: 332 VVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAV 391
Query: 357 IDQKQFDKILELIESGKKE-GAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGP 415
ID K F +I + +E + + GG + G F++P + I KEEIFGP
Sbjct: 392 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGP 451
Query: 416 -----VQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALE--SGTVWIN-- 466
V P K+K +++ ++T YGLT AVF+++ D + L +G +IN
Sbjct: 452 VLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDK 509
Query: 467 CYNALYAQAPFGGFKMSG-NGRELGEYALAEYTE---VKTVTIKLGD 509
++ Q PFGG + SG N + G + + +T +K LGD
Sbjct: 510 STGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGD 556
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 156 bits (394), Expect = 5e-38
Identities = 137/467 (29%), Positives = 217/467 (46%), Gaps = 32/467 (6%)
Query: 67 DKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDR-ATLAALETMDTGKP 125
DK ++KA+EAA A + W R ++ + AD++ R A + A + GK
Sbjct: 38 DKSLLNKAIEAALAARKE---WDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKT 94
Query: 126 FLHAFFIDLEGCIRTLRYFAGWADKIQGK---TIPTDDNVVCFTRHEPIGVCGAITPWNF 182
+ A I R+ A +A +++G+ ++P N + E G AI+P+NF
Sbjct: 95 VIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--GFVAAISPFNF 152
Query: 183 PLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGA 242
+ APAL GN ++ KP++ L + + +++EAG PP ++ VP GP G
Sbjct: 153 TAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGD 211
Query: 243 AISSHPQINKIAFTGSTEVGK-LVKEAASR----SNLKRVTLELGGKNPCIVCADADLDL 297
++S + I FTGS K L K+ A R+ E GGKN V AD++
Sbjct: 212 TVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVES 271
Query: 298 AVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPF-DVKTEQGPQ 356
V + F GQ C+A SR++V ++ + R +E + VGDP D T
Sbjct: 272 VVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAV 331
Query: 357 IDQKQFDKILELIESGKKE-GAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGP 415
ID K F +I + +E + + GG + G F++P + I KEEIFGP
Sbjct: 332 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGP 391
Query: 416 -----VQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALE--SGTVWIN-- 466
V P K+K +++ ++T YGLT AVF+++ D + L +G +IN
Sbjct: 392 VLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDK 449
Query: 467 CYNALYAQAPFGGFKMSG-NGRELGEYALAEYTE---VKTVTIKLGD 509
++ Q PFGG + SG N + G + + +T +K LGD
Sbjct: 450 STGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGD 496
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 156 bits (394), Expect = 5e-38
Identities = 137/467 (29%), Positives = 217/467 (46%), Gaps = 32/467 (6%)
Query: 67 DKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDR-ATLAALETMDTGKP 125
DK ++KA+EAA A + W R ++ + AD++ R A + A + GK
Sbjct: 98 DKSLLNKAIEAALAARKE---WDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKT 154
Query: 126 FLHAFFIDLEGCIRTLRYFAGWADKIQGK---TIPTDDNVVCFTRHEPIGVCGAITPWNF 182
+ A I R+ A +A +++G+ ++P N + E G AI+P+NF
Sbjct: 155 VIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--GFVAAISPFNF 212
Query: 183 PLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGA 242
+ APAL GN ++ KP++ L + + +++EAG PP ++ VP GP G
Sbjct: 213 TAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGD 271
Query: 243 AISSHPQINKIAFTGSTEVGK-LVKEAASR----SNLKRVTLELGGKNPCIVCADADLDL 297
++S + I FTGS K L K+ A R+ E GGKN V AD++
Sbjct: 272 TVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVES 331
Query: 298 AVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPF-DVKTEQGPQ 356
V + F GQ C+A SR++V ++ + R +E + VGDP D T
Sbjct: 332 VVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAV 391
Query: 357 IDQKQFDKILELIESGKKE-GAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGP 415
ID K F +I + +E + + GG + G F++P + I KEEIFGP
Sbjct: 392 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGP 451
Query: 416 -----VQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALE--SGTVWIN-- 466
V P K+K +++ ++T YGLT AVF+++ D + L +G +IN
Sbjct: 452 VLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDK 509
Query: 467 CYNALYAQAPFGGFKMSG-NGRELGEYALAEYTE---VKTVTIKLGD 509
++ Q PFGG + SG N + G + + +T +K LGD
Sbjct: 510 STGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGD 556
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 148 bits (374), Expect = 1e-35
Identities = 102/344 (29%), Positives = 169/344 (49%), Gaps = 13/344 (3%)
Query: 165 FTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAG 224
+ + +P+GV I WN+P ++ + L A+ GN +++KP+E + TA L L+ +
Sbjct: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL 155
Query: 225 FPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGK 284
+ I G T + + I +TG+T VGK+V EAA++ +L VTLELGGK
Sbjct: 156 DQDLYIVINGGVEETTELL---KQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGK 211
Query: 285 NPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVG 344
+PC + D DLD+ G + N GQ C A + E + ++ V + E K+ G
Sbjct: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YG 270
Query: 345 DPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDN 404
+ + I+ + F +IL L+ EG K+ GG ++ +I PTV ++V
Sbjct: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGET-DEATRYIAPTVLTDVDPK 324
Query: 405 MRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVW 464
++ +EEIFGP+ PI+ K+++E I N + L VF+ N ++ SG V
Sbjct: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVT 384
Query: 465 IN--CYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIK 506
N + PFGG SG G G+++ ++ + +K
Sbjct: 385 GNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 148 bits (374), Expect = 1e-35
Identities = 102/344 (29%), Positives = 169/344 (49%), Gaps = 13/344 (3%)
Query: 165 FTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAG 224
+ + +P+GV I WN+P ++ + L A+ GN +++KP+E + TA L L+ +
Sbjct: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL 155
Query: 225 FPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGK 284
+ I G T + + I +TG+T VGK+V EAA++ +L VTLELGGK
Sbjct: 156 DQDLYIVINGGVEETTELL---KQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGK 211
Query: 285 NPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVG 344
+PC + D DLD+ G + N GQ C A + E + ++ V + E K+ G
Sbjct: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YG 270
Query: 345 DPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDN 404
+ + I+ + F +IL L+ EG K+ GG ++ +I PTV ++V
Sbjct: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGET-DEATRYIAPTVLTDVDPK 324
Query: 405 MRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVW 464
++ +EEIFGP+ PI+ K+++E I N + L VF+ N ++ SG V
Sbjct: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVT 384
Query: 465 IN--CYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIK 506
N + PFGG SG G G+++ ++ + +K
Sbjct: 385 GNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 141 bits (356), Expect = 1e-33
Identities = 105/344 (30%), Positives = 166/344 (48%), Gaps = 13/344 (3%)
Query: 165 FTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAG 224
F R EP G+ I PWN+PL + + L AL GN +VLKP+E + L ++ +
Sbjct: 99 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 157
Query: 225 FPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGK 284
+V G GP + H + + I FTGS VGK+V AA++ +L VTLELGGK
Sbjct: 158 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 214
Query: 285 NPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVG 344
NPC V + D +FN GQ C A V ++ E + +++ R G
Sbjct: 215 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEM-QERLLPALQSTITRFYG 273
Query: 345 DPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDN 404
D G I+QKQF ++ L+ G ++ GG + ++ +I PTV +V +
Sbjct: 274 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 327
Query: 405 MRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVW 464
+ +EEIFGP+ PI+ +S++E I+ N + L F+ + ++ + SG
Sbjct: 328 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 387
Query: 465 IN--CYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIK 506
N + A PFGG SG GR G+++ ++ + ++
Sbjct: 388 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLR 431
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 141 bits (356), Expect = 1e-33
Identities = 105/344 (30%), Positives = 166/344 (48%), Gaps = 13/344 (3%)
Query: 165 FTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAG 224
F R EP G+ I PWN+PL + + L AL GN +VLKP+E + L ++ +
Sbjct: 62 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 120
Query: 225 FPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGK 284
+V G GP + H + + I FTGS VGK+V AA++ +L VTLELGGK
Sbjct: 121 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 177
Query: 285 NPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVG 344
NPC V + D +FN GQ C A V ++ E + +++ R G
Sbjct: 178 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEM-QERLLPALQSTITRFYG 236
Query: 345 DPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDN 404
D G I+QKQF ++ L+ G ++ GG + ++ +I PTV +V +
Sbjct: 237 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 290
Query: 405 MRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVW 464
+ +EEIFGP+ PI+ +S++E I+ N + L F+ + ++ + SG
Sbjct: 291 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 350
Query: 465 IN--CYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIK 506
N + A PFGG SG GR G+++ ++ + ++
Sbjct: 351 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLR 394
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 141 bits (356), Expect = 1e-33
Identities = 105/344 (30%), Positives = 166/344 (48%), Gaps = 13/344 (3%)
Query: 165 FTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAG 224
F R EP G+ I PWN+PL + + L AL GN +VLKP+E + L ++ +
Sbjct: 99 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 157
Query: 225 FPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGK 284
+V G GP + H + + I FTGS VGK+V AA++ +L VTLELGGK
Sbjct: 158 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 214
Query: 285 NPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVG 344
NPC V + D +FN GQ C A V ++ E + +++ R G
Sbjct: 215 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEM-QERLLPALQSTITRFYG 273
Query: 345 DPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDN 404
D G I+QKQF ++ L+ G ++ GG + ++ +I PTV +V +
Sbjct: 274 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 327
Query: 405 MRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVW 464
+ +EEIFGP+ PI+ +S++E I+ N + L F+ + ++ + SG
Sbjct: 328 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 387
Query: 465 IN--CYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIK 506
N + A PFGG SG GR G+++ ++ + ++
Sbjct: 388 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLR 431
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 141 bits (356), Expect = 1e-33
Identities = 108/341 (31%), Positives = 166/341 (48%), Gaps = 15/341 (4%)
Query: 165 FTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAG 224
F EP G+ I PWN+PL + + L AL G+ +VLKP+E + T L ++ +
Sbjct: 18 FIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY- 76
Query: 225 FPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGK 284
+V G GP + H +++ I FTGS VGK+V AA++ +L VTLELGGK
Sbjct: 77 LDQSCFAVVLG-GPQETGQLLEH-KLDYIFFTGSPRVGKIVMTAATK-HLTPVTLELGGK 133
Query: 285 NPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVG 344
NPC V + D +FN GQ C A V ++ E + +++ R G
Sbjct: 134 NPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEM-QERLLPALQSTITRFYG 192
Query: 345 DPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDN 404
D G I+QKQF ++ L+ G+ + GG + E +I PTV +V +
Sbjct: 193 DDPQSSPNLGRIINQKQFQRLRALLGCGR-----VAIGGQSNESDR-YIAPTVLVDVQET 246
Query: 405 MRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVW 464
+ +EEIFGP+ PI+ +S++E IK N + L F+ + ++ SG+
Sbjct: 247 EPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGSFG 306
Query: 465 IN---CYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKT 502
N Y +L + PFGG SG GR G++ ++ +T
Sbjct: 307 GNEGFTYISLLS-VPFGGVGHSGMGRYHGKFTFDTFSHHRT 346
>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 141 bits (356), Expect = 1e-33
Identities = 108/341 (31%), Positives = 166/341 (48%), Gaps = 15/341 (4%)
Query: 165 FTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAG 224
F EP G+ I PWN+PL + + L AL G+ +VLKP+E + T L ++ +
Sbjct: 18 FIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY- 76
Query: 225 FPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGK 284
+V G GP + H +++ I FTGS VGK+V AA++ +L VTLELGGK
Sbjct: 77 LDQSCFAVVLG-GPQETGQLLEH-KLDYIFFTGSPRVGKIVMTAATK-HLTPVTLELGGK 133
Query: 285 NPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVG 344
NPC V + D +FN GQ C A V ++ E + +++ R G
Sbjct: 134 NPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEM-QERLLPALQSTITRFYG 192
Query: 345 DPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDN 404
D G I+QKQF ++ L+ G+ + GG + E +I PTV +V +
Sbjct: 193 DDPQSSPNLGRIINQKQFQRLRALLGCGR-----VAIGGQSNESDR-YIAPTVLVDVQET 246
Query: 405 MRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVW 464
+ +EEIFGP+ PI+ +S++E IK N + L F+ + ++ SG+
Sbjct: 247 EPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGSFG 306
Query: 465 IN---CYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKT 502
N Y +L + PFGG SG GR G++ ++ +T
Sbjct: 307 GNEGFTYISLLS-VPFGGVGHSGMGRYHGKFTFDTFSHHRT 346
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,593,173
Number of Sequences: 37866
Number of extensions: 900355
Number of successful extensions: 2103
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1965
Number of HSP's gapped (non-prelim): 42
length of query: 512
length of database: 18,247,518
effective HSP length: 107
effective length of query: 405
effective length of database: 14,195,856
effective search space: 5749321680
effective search space used: 5749321680
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.