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Search of human proteins with 110225351
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
(1193 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens] 2380 0.0
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens] 1685 0.0
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens] 1238 0.0
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens] 1236 0.0
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 968 0.0
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 961 0.0
gi|21071077 dishevelled-associated activator of morphogenesis 1 ... 426 e-119
gi|40548415 dishevelled associated activator of morphogenesis 2 ... 392 e-108
gi|119120861 formin-like 3 isoform 2 [Homo sapiens] 303 5e-82
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens] 299 9e-81
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens] 299 9e-81
gi|119120874 formin-like 3 isoform 1 [Homo sapiens] 285 1e-76
gi|52485606 formin-like 2 [Homo sapiens] 272 1e-72
gi|33356148 formin-like 1 [Homo sapiens] 243 1e-63
gi|157168329 formin 1 [Homo sapiens] 200 6e-51
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 184 3e-46
gi|160707881 formin 2 [Homo sapiens] 180 6e-45
gi|145309324 FH2 domain containing 1 [Homo sapiens] 179 1e-44
gi|58331242 formin homology 2 domain containing 3 [Homo sapiens] 155 3e-37
gi|118572599 formin homology 2 domain containing 1 [Homo sapiens] 139 2e-32
gi|14249316 hypothetical protein LOC84800 [Homo sapiens] 70 9e-12
gi|56549694 enabled homolog isoform a [Homo sapiens] 70 2e-11
gi|39930375 enabled homolog isoform b [Homo sapiens] 70 2e-11
gi|210032580 SET domain containing 1B [Homo sapiens] 67 1e-10
gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens] 63 1e-09
gi|183396804 Regulation of nuclear pre-mRNA domain containing 2 ... 63 2e-09
gi|11386183 WAS protein family, member 2 [Homo sapiens] 60 9e-09
gi|149944526 additional sex combs like 3 [Homo sapiens] 59 4e-08
gi|10937869 survival of motor neuron 2, centromeric isoform d [H... 58 5e-08
gi|13259527 survival of motor neuron 2, centromeric isoform a [H... 58 5e-08
>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
Length = 1193
Score = 2380 bits (6167), Expect = 0.0
Identities = 1193/1193 (100%), Positives = 1193/1193 (100%)
Query: 1 MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKGPQHPPPPSGPEEPGEKRPKF 60
MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKGPQHPPPPSGPEEPGEKRPKF
Sbjct: 1 MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKGPQHPPPPSGPEEPGEKRPKF 60
Query: 61 HLNIRTLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASSDCSAAPLEMMENFPKPLSEN 120
HLNIRTLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASSDCSAAPLEMMENFPKPLSEN
Sbjct: 61 HLNIRTLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASSDCSAAPLEMMENFPKPLSEN 120
Query: 121 ELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYINTASKTGSLKRSRQISPQEFI 180
ELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYINTASKTGSLKRSRQISPQEFI
Sbjct: 121 ELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYINTASKTGSLKRSRQISPQEFI 180
Query: 181 HELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDILEKLISGKIQEKVVK 240
HELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDILEKLISGKIQEKVVK
Sbjct: 181 HELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDILEKLISGKIQEKVVK 240
Query: 241 KNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGE 300
KNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGE
Sbjct: 241 KNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGE 300
Query: 301 ESILEEVLEALTSAGEEKKIDRFFCIVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLH 360
ESILEEVLEALTSAGEEKKIDRFFCIVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLH
Sbjct: 301 ESILEEVLEALTSAGEEKKIDRFFCIVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLH 360
Query: 361 IRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDV 420
IRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDV
Sbjct: 361 IRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDV 420
Query: 421 YNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFT 480
YNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFT
Sbjct: 421 YNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFT 480
Query: 481 YRKRLDLDLTQFVDICIDQAKLEEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINEL 540
YRKRLDLDLTQFVDICIDQAKLEEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINEL
Sbjct: 481 YRKRLDLDLTQFVDICIDQAKLEEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINEL 540
Query: 541 QAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLP 600
QAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLP
Sbjct: 541 QAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLP 600
Query: 601 GMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMT 660
GMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMT
Sbjct: 601 GMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMT 660
Query: 661 ENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIA 720
ENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIA
Sbjct: 661 ENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIA 720
Query: 721 QNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNL 780
QNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNL
Sbjct: 721 QNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNL 780
Query: 781 CEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLL 840
CEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLL
Sbjct: 781 CEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLL 840
Query: 841 ELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNF 900
ELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNF
Sbjct: 841 ELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNF 900
Query: 901 VDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISA 960
VDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISA
Sbjct: 901 VDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISA 960
Query: 961 KEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKRE 1020
KEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKRE
Sbjct: 961 KEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKRE 1020
Query: 1021 AEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRK 1080
AEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRK
Sbjct: 1021 AEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRK 1080
Query: 1081 RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNL 1140
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNL
Sbjct: 1081 RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNL 1140
Query: 1141 DTHTSTGRIKAAEKKEACNVESNRKKETELLGSFSKNESVPEVEALLARLRAL 1193
DTHTSTGRIKAAEKKEACNVESNRKKETELLGSFSKNESVPEVEALLARLRAL
Sbjct: 1141 DTHTSTGRIKAAEKKEACNVESNRKKETELLGSFSKNESVPEVEALLARLRAL 1193
>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
Length = 849
Score = 1685 bits (4364), Expect = 0.0
Identities = 844/846 (99%), Positives = 845/846 (99%)
Query: 264 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRF 323
MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRF
Sbjct: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRF 60
Query: 324 FCIVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKND 383
FCIVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKND
Sbjct: 61 FCIVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKND 120
Query: 384 GLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQH 443
GLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQH
Sbjct: 121 GLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQH 180
Query: 444 LLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLE 503
LLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLE
Sbjct: 181 LLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLE 240
Query: 504 EFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLP 563
EFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLP
Sbjct: 241 EFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLP 300
Query: 564 PSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQN 623
PSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQN
Sbjct: 301 PSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQN 360
Query: 624 SPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLE 683
SPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLE
Sbjct: 361 SPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLE 420
Query: 684 NTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILE 743
NTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILE
Sbjct: 421 NTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILE 480
Query: 744 VDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAI 803
VDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAI
Sbjct: 481 VDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAI 540
Query: 804 LFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFN 863
LFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFN
Sbjct: 541 LFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFN 600
Query: 864 LSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLR 923
LSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLR
Sbjct: 601 LSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLR 660
Query: 924 QMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIG 983
QMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIG
Sbjct: 661 QMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIG 720
Query: 984 YYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQ 1043
YYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQ
Sbjct: 721 YYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQ 780
Query: 1044 QKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKV 1103
QKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKV
Sbjct: 781 QKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQSLSPMSQRPVLKV 840
Query: 1104 CNHENQ 1109
CNH N+
Sbjct: 841 CNHGNK 846
>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
Length = 1101
Score = 1238 bits (3202), Expect = 0.0
Identities = 624/1058 (58%), Positives = 819/1058 (77%), Gaps = 26/1058 (2%)
Query: 51 EEPGEKRPKFHLNIRTLTDDMLDKFASIRIPGSKKERPPLPN-LKTAFASSDCSAAPLEM 109
EE + +PK ++ I+TL DD+ D+ S R KKE+P + + + + A S+ AA +
Sbjct: 35 EEETKNKPKLNIQIKTLADDVRDRITSFRKSTVKKEKPLIQHPIDSQVAMSEFPAAQ-PL 93
Query: 110 MENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYINTASKTGSLK 169
+ LSE E+L+LFEKMMEDMNLNE+KKAPLR KDF+ K+EMV+QYI+ +K+G LK
Sbjct: 94 YDERSLNLSEKEVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMVVQYISATAKSGGLK 153
Query: 170 RSRQ---ISPQEFIHELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDIL 226
S+ +S QE++HEL+ G +DE+L+ CLESLRVSLTSNPVSWV +FGHEGLGLLLD L
Sbjct: 154 NSKHECTLSSQEYVHELRSGISDEKLLNCLESLRVSLTSNPVSWVNNFGHEGLGLLLDEL 213
Query: 227 EKLISGKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMT 286
EKL+ K QE + KKNQ+K+IQCLKA MN ++GL+RI+ +ERSL LLA+A+DP+ PNMMT
Sbjct: 214 EKLLDKKQQENIDKKNQYKLIQCLKAFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMT 273
Query: 287 DVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRFFCIVEGLRHN-SVQLQVACMQLI 345
++VK+LSA+CIVGEE+IL+++L A+T+A E +RF IVEGL + ++QLQVACMQ I
Sbjct: 274 EIVKILSAICIVGEENILDKLLGAITTAAERNNRERFSPIVEGLENQEALQLQVACMQFI 333
Query: 346 NALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSH 405
NALVTSP +LDFR+H+RNEF+R GLK +LP+LK +ND LDIQLKVFDE+KE+DL ELSH
Sbjct: 334 NALVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSH 393
Query: 406 RLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECV 465
RL DIRAE+D+ +VY+++++ +K+T AE YF+SILQH LLIRNDY+IR QY+K+I+ECV
Sbjct: 394 RLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECV 453
Query: 466 SQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFEEKASELYKKFEKEFTDHQE 525
SQIVLH GMDPDF YR+RLD+DLT +D C+++AK+EE E+KA+E KKF++EFT QE
Sbjct: 454 SQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQE 513
Query: 526 TQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEG--GTGHSALPPPPPLPS 583
QAELQK++ KI EL+AE+Q ++Q L + IP PP+ G G PP PPLP
Sbjct: 514 AQAELQKRDEKIKELEAEIQQLRTQAQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPG 573
Query: 584 GGGVPPPPPP-------PPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPP--LPILPFGL 634
G +PPPPPP PPPPP P + F GP PPPP LGG PP LP+G+
Sbjct: 574 GAPLPPPPPPLPGMMGIPPPPPPP---LLFGGPPPPPP----LGGVPPPPGISLNLPYGM 626
Query: 635 KPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERR 694
K KK +KPE+SM+R+NW KI P E++ENCFW++V E+K+EN DL KL F Q K ++
Sbjct: 627 KQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFATQIKVQK 686
Query: 695 EEEDIEEKKS--IKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAES 752
E +EEKK+ KKK+KEL+ LD K AQNLSIFL S+R+PYE+IR +ILEV+E L+E+
Sbjct: 687 NAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEA 746
Query: 753 MIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQ 812
+IQNL+KHLP+Q+ LN L++ K+EY +LCEPEQF VVMS+VK L+PRLS+ILFKL FEE
Sbjct: 747 LIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEH 806
Query: 813 VNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKD 872
+NNIKP I+AV+ ACEE+KKS+SF++LLELVLL+GNYMN+GSRNAQ+ GF ++ LCK++D
Sbjct: 807 INNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRD 866
Query: 873 TKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQL 932
TKSADQKTTLLHF+ +ICEEKY DIL F ++LE ++ ASKVS + L+ NL M +Q+ L
Sbjct: 867 TKSADQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHL 926
Query: 933 EKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKV 992
E++++ FP E+ HDKFV KM+ F +A+EQYE LS +H NM KLY+++ Y+ D K V
Sbjct: 927 ERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTV 986
Query: 993 SVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEM 1052
S+E+F DLNNFRT F++A++EN K+RE EEK +R ++AKE AE+E+LERQ+KKK+L+++
Sbjct: 987 SIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDI 1046
Query: 1053 KTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDVRQ 1090
EGDETGVMDNLLEALQSGAAFRDRRKR P D R+
Sbjct: 1047 NKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNPDNRR 1084
>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
Length = 1096
Score = 1236 bits (3197), Expect = 0.0
Identities = 622/1051 (59%), Positives = 816/1051 (77%), Gaps = 26/1051 (2%)
Query: 51 EEPGEKRPKFHLNIRTLTDDMLDKFASIRIPGSKKERPPLPN-LKTAFASSDCSAAPLEM 109
EE + +PK ++ I+TL DD+ D+ S R KKE+P + + + + A S+ AA +
Sbjct: 35 EEETKNKPKLNIQIKTLADDVRDRITSFRKSTVKKEKPLIQHPIDSQVAMSEFPAAQ-PL 93
Query: 110 MENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYINTASKTGSLK 169
+ LSE E+L+LFEKMMEDMNLNE+KKAPLR KDF+ K+EMV+QYI+ +K+G LK
Sbjct: 94 YDERSLNLSEKEVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMVVQYISATAKSGGLK 153
Query: 170 RSRQ---ISPQEFIHELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDIL 226
S+ +S QE++HEL+ G +DE+L+ CLESLRVSLTSNPVSWV +FGHEGLGLLLD L
Sbjct: 154 NSKHECTLSSQEYVHELRSGISDEKLLNCLESLRVSLTSNPVSWVNNFGHEGLGLLLDEL 213
Query: 227 EKLISGKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMT 286
EKL+ K QE + KKNQ+K+IQCLKA MN ++GL+RI+ +ERSL LLA+A+DP+ PNMMT
Sbjct: 214 EKLLDKKQQENIDKKNQYKLIQCLKAFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMT 273
Query: 287 DVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRFFCIVEGLRHN-SVQLQVACMQLI 345
++VK+LSA+CIVGEE+IL+++L A+T+A E +RF IVEGL + ++QLQVACMQ I
Sbjct: 274 EIVKILSAICIVGEENILDKLLGAITTAAERNNRERFSPIVEGLENQEALQLQVACMQFI 333
Query: 346 NALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSH 405
NALVTSP +LDFR+H+RNEF+R GLK +LP+LK +ND LDIQLKVFDE+KE+DL ELSH
Sbjct: 334 NALVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSH 393
Query: 406 RLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECV 465
RL DIRAE+D+ +VY+++++ +K+T AE YF+SILQH LLIRNDY+IR QY+K+I+ECV
Sbjct: 394 RLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECV 453
Query: 466 SQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFEEKASELYKKFEKEFTDHQE 525
SQIVLH GMDPDF YR+RLD+DLT +D C+++AK+EE E+KA+E KKF++EFT QE
Sbjct: 454 SQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQE 513
Query: 526 TQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEG--GTGHSALPPPPPLPS 583
QAELQK++ KI EL+AE+Q ++Q L + IP PP+ G G PP PPLP
Sbjct: 514 AQAELQKRDEKIKELEAEIQQLRTQAQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPG 573
Query: 584 GGGVPPPPPP-------PPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPP--LPILPFGL 634
G +PPPPPP PPPPP P + F GP PPPP LGG PP LP+G+
Sbjct: 574 GAPLPPPPPPLPGMMGIPPPPPPP---LLFGGPPPPPP----LGGVPPPPGISLNLPYGM 626
Query: 635 KPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERR 694
K KK +KPE+SM+R+NW KI P E++ENCFW++V E+K+EN DL KL F Q K ++
Sbjct: 627 KQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFATQIKVQK 686
Query: 695 EEEDIEEKKS--IKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAES 752
E +EEKK+ KKK+KEL+ LD K AQNLSIFL S+R+PYE+IR +ILEV+E L+E+
Sbjct: 687 NAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEA 746
Query: 753 MIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQ 812
+IQNL+KHLP+Q+ LN L++ K+EY +LCEPEQF VVMS+VK L+PRLS+ILFKL FEE
Sbjct: 747 LIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEH 806
Query: 813 VNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKD 872
+NNIKP I+AV+ ACEE+KKS+SF++LLELVLL+GNYMN+GSRNAQ+ GF ++ LCK++D
Sbjct: 807 INNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRD 866
Query: 873 TKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQL 932
TKSADQKTTLLHF+ +ICEEKY DIL F ++LE ++ ASKVS + L+ NL M +Q+ L
Sbjct: 867 TKSADQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHL 926
Query: 933 EKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKV 992
E++++ FP E+ HDKFV KM+ F +A+EQYE LS +H NM KLY+++ Y+ D K V
Sbjct: 927 ERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTV 986
Query: 993 SVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEM 1052
S+E+F DLNNFRT F++A++EN K+RE EEK +R ++AKE AE+E+LERQ+KKK+L+++
Sbjct: 987 SIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDI 1046
Query: 1053 KTEGDETGVMDNLLEALQSGAAFRDRRKRTP 1083
EGDETGVMDNLLEALQSGAAFRDRRKR P
Sbjct: 1047 NKEGDETGVMDNLLEALQSGAAFRDRRKRIP 1077
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 968 bits (2502), Expect = 0.0
Identities = 554/1227 (45%), Positives = 753/1227 (61%), Gaps = 191/1227 (15%)
Query: 28 RGCRESKMPRRKGPQHPPPPSGPEEPGEKRPKFHLNIRTLTDDMLDKFASIRIPGSKKER 87
RG R+ K R P P G G K KF L + L D L++F S+RI K++
Sbjct: 12 RGTRDKKKGR--SPDELPSAGGD---GGKSKKFTL--KRLMADELERFTSMRIKKEKEKP 64
Query: 88 PPLPNLKTAFASSDCSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKD 147
+A D +A L+ +S+ ++L LFE+M+ DMNLNE+K+ PLREKD
Sbjct: 65 NSAHRNSSASYGDDPTAQSLQ-------DVSDEQVLVLFEQMLLDMNLNEEKQQPLREKD 117
Query: 148 FSIKKEMVMQYINTASKTGSLKRSRQISPQEFIHELKMGSADERLVTCLESLRVSLTSNP 207
IK+EMV QY+ T SK G ++ S +I EL+ G D L++CLESLRVSL +NP
Sbjct: 118 IIIKREMVSQYLYT-SKAGMSQKESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNP 176
Query: 208 VSWVESFGHEGLGLLLDILEKLISGKIQE--KVVKKNQHKVIQCLKALMNTQYGLERIMS 265
VSWV++FG EGL LLDIL++L K + +N+H++I+CLKA MN ++G++ ++
Sbjct: 177 VSWVQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLE 236
Query: 266 EERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGE-ESILEEVLEALTSAGEEKKIDRFF 324
E + LL +A+DP PNMM D KLLSA+CI+ + E + E VLEA+T E +++RF
Sbjct: 237 TEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQ 296
Query: 325 CIVEGLRHNS-VQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKND 383
+++GL+ + + L+V C+QLINAL+T ++LDFR+HIR+E MR GL ++L +L+ I+N+
Sbjct: 297 PLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENE 356
Query: 384 GLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQH 443
+ +QL VFDE EED ++L RL+DIR E+D+ +V+ ++ +TVK+++AE +F+SILQH
Sbjct: 357 DMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQH 416
Query: 444 LLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLE 503
LLL+RNDY R QY+KLI+EC+SQIVLH++G DPDF R L +++ +D ID+ K+E
Sbjct: 417 LLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCR-HLQIEIEGLIDQMIDKTKVE 475
Query: 504 EFEEKASEL-----------------YKKFEKEF----------------------TDHQ 524
+ E KA+EL KK E +F T+ Q
Sbjct: 476 KSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQ 535
Query: 525 ETQAELQKKEAKINELQAELQAFKSQFGAL------------------------------ 554
+ +AE+ + ++ +L EL+ K + +L
Sbjct: 536 DLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTI 595
Query: 555 ------PADCNIPLPPSKE--------GGT---------GHSALPPPPP----------- 580
P D P PP GG G +A+ PPPP
Sbjct: 596 IPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPP 655
Query: 581 -------------LPSGGGVPPPPP-------PPPPPPLPGMR----------------- 603
LP G +PPPPP PPPPPPLPG
Sbjct: 656 PLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPP 715
Query: 604 ----MPFSGPVPPPPPLGFLGGQNSPP-------------------LPILPFGLKPKKEF 640
+P +PPPPP F GG PP P+LPFGL PKK +
Sbjct: 716 PPPPLPGGPGIPPPPP--FPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLY 773
Query: 641 KPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQ---QKERREEE 697
KPE+ +RR NW K+ +++++CFW KV E+++EN +L KL TF Q K ++++E
Sbjct: 774 KPEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQE 833
Query: 698 DIEEKKSI-KKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQN 756
EEKKS+ KKK+KELK LDSK AQNLSIFL SFR+PY+EI+ +ILEV+E L ESMIQN
Sbjct: 834 GGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQN 893
Query: 757 LIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNI 816
LIK +P+ EQL LS+ K EY +L E EQF VVM V RLRPRL+AILFKLQF EQV NI
Sbjct: 894 LIKQMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENI 953
Query: 817 KPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSA 876
KP+I++V+ ACEE++KS+SFS LLE+ LL+GNYMNAGSRNA FGFN+S LCKL+DTKS
Sbjct: 954 KPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKST 1013
Query: 877 DQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKEL 936
DQK TLLHFL E+CE YPD+L F D+L ++KAS+VS E L+KNL QM +Q+ +E+++
Sbjct: 1014 DQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDV 1073
Query: 937 ETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVED 996
+ FP D DKFV KM+ FV A+EQY L +H NME LY+ + Y+ D KK+SVE+
Sbjct: 1074 QNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEE 1133
Query: 997 FLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEG 1056
F DL+NFR F+QA+KEN K+RE EEK +R ++AKE AE+ERLE+QQK+++L++M EG
Sbjct: 1134 FFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEG 1193
Query: 1057 DETGVMDNLLEALQSGAAFRDRRKRTP 1083
DETGVMD+LLEALQSGAAF RRKR P
Sbjct: 1194 DETGVMDSLLEALQSGAAF--RRKRGP 1218
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 961 bits (2485), Expect = 0.0
Identities = 551/1227 (44%), Positives = 749/1227 (61%), Gaps = 200/1227 (16%)
Query: 28 RGCRESKMPRRKGPQHPPPPSGPEEPGEKRPKFHLNIRTLTDDMLDKFASIRIPGSKKER 87
RG R+ K R P P G G K KF L++F S+RI K++
Sbjct: 12 RGTRDKKKGR--SPDELPSAGGD---GGKSKKF-----------LERFTSMRIKKEKEKP 55
Query: 88 PPLPNLKTAFASSDCSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKD 147
+A D +A L+ +S+ ++L LFE+M+ DMNLNE+K+ PLREKD
Sbjct: 56 NSAHRNSSASYGDDPTAQSLQ-------DVSDEQVLVLFEQMLLDMNLNEEKQQPLREKD 108
Query: 148 FSIKKEMVMQYINTASKTGSLKRSRQISPQEFIHELKMGSADERLVTCLESLRVSLTSNP 207
IK+EMV QY+ T SK G ++ S +I EL+ G D L++CLESLRVSL +NP
Sbjct: 109 IIIKREMVSQYLYT-SKAGMSQKESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNP 167
Query: 208 VSWVESFGHEGLGLLLDILEKLISGKIQE--KVVKKNQHKVIQCLKALMNTQYGLERIMS 265
VSWV++FG EGL LLDIL++L K + +N+H++I+CLKA MN ++G++ ++
Sbjct: 168 VSWVQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLE 227
Query: 266 EERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGE-ESILEEVLEALTSAGEEKKIDRFF 324
E + LL +A+DP PNMM D KLLSA+CI+ + E + E VLEA+T E +++RF
Sbjct: 228 TEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQ 287
Query: 325 CIVEGLRHNS-VQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKND 383
+++GL+ + + L+V C+QLINAL+T ++LDFR+HIR+E MR GL ++L +L+ I+N+
Sbjct: 288 PLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENE 347
Query: 384 GLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQH 443
+ +QL VFDE EED ++L RL+DIR E+D+ +V+ ++ +TVK+++AE +F+SILQH
Sbjct: 348 DMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQH 407
Query: 444 LLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLE 503
LLL+RNDY R QY+KLI+EC+SQIVLH++G DPDF R L +++ +D ID+ K+E
Sbjct: 408 LLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCR-HLQIEIEGLIDQMIDKTKVE 466
Query: 504 EFEEKASEL-----------------YKKFEKEF----------------------TDHQ 524
+ E KA+EL KK E +F T+ Q
Sbjct: 467 KSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQ 526
Query: 525 ETQAELQKKEAKINELQAELQAFKSQFGAL------------------------------ 554
+ +AE+ + ++ +L EL+ K + +L
Sbjct: 527 DLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTI 586
Query: 555 ------PADCNIPLPPSKE--------GGT---------GHSALPPPPP----------- 580
P D P PP GG G +A+ PPPP
Sbjct: 587 IPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPP 646
Query: 581 -------------LPSGGGVPPPPP-------PPPPPPLPGMR----------------- 603
LP G +PPPPP PPPPPPLPG
Sbjct: 647 PLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPP 706
Query: 604 ----MPFSGPVPPPPPLGFLGGQNSPP-------------------LPILPFGLKPKKEF 640
+P +PPPPP F GG PP P+LPFGL PKK +
Sbjct: 707 PPPPLPGGPGIPPPPP--FPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLY 764
Query: 641 KPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQ---QKERREEE 697
KPE+ +RR NW K+ +++++CFW KV E+++EN +L KL TF Q K ++++E
Sbjct: 765 KPEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQE 824
Query: 698 DIEEKKSI-KKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQN 756
EEKKS+ KKK+KELK LDSK AQNLSIFL SFR+PY+EI+ +ILEV+E L ESMIQN
Sbjct: 825 GGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQN 884
Query: 757 LIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNI 816
LIK +P+ EQL LS+ K EY +L E EQF VVM V RLRPRL+AILFKLQF EQV NI
Sbjct: 885 LIKQMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENI 944
Query: 817 KPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSA 876
KP+I++V+ ACEE++KS+SFS LLE+ LL+GNYMNAGSRNA FGFN+S LCKL+DTKS
Sbjct: 945 KPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKST 1004
Query: 877 DQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKEL 936
DQK TLLHFL E+CE YPD+L F D+L ++KAS+VS E L+KNL QM +Q+ +E+++
Sbjct: 1005 DQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDV 1064
Query: 937 ETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVED 996
+ FP D DKFV KM+ FV A+EQY L +H NME LY+ + Y+ D KK+SVE+
Sbjct: 1065 QNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEE 1124
Query: 997 FLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEG 1056
F DL+NFR F+QA+KEN K+RE EEK +R ++AKE AE+ERLE+QQK+++L++M EG
Sbjct: 1125 FFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEG 1184
Query: 1057 DETGVMDNLLEALQSGAAFRDRRKRTP 1083
DETGVMD+LLEALQSGAAF RRKR P
Sbjct: 1185 DETGVMDSLLEALQSGAAF--RRKRGP 1209
>gi|21071077 dishevelled-associated activator of morphogenesis 1 [Homo
sapiens]
Length = 1078
Score = 426 bits (1096), Expect = e-119
Identities = 306/1084 (28%), Positives = 544/1084 (50%), Gaps = 119/1084 (10%)
Query: 100 SDCSAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYI 159
+D + A M P P E EL +F +++++++L + RE F++ E Q
Sbjct: 32 NDSNFALQTMEPALPMPPVE-ELDVMFSELVDELDLTDKH----REAMFALPAEKKWQIY 86
Query: 160 NTASKTGSLKRSRQISPQEFIHELKMGSADERLVTC-----------LESLRVSLTSNPV 208
+ K + P+ +I +L +A + L+ +ESL+ +L + P+
Sbjct: 87 CSKKKDQEENKGATSWPEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPM 146
Query: 209 SWVESF-GHEGLGLLLDILEKLISGKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEE 267
+V F +GL +L+ L+ + + ++ +I C+KALMN G +++
Sbjct: 147 RFVTRFIDLDGLSCILNFLKTMDYETSESRI----HTSLIGCIKALMNNSQGRAHVLAHS 202
Query: 268 RSLSLLAKAVDPRHPNMMTDVVKLLSAVCIV--GEESILEEVLEALTSAGEEKKIDRFFC 325
S++++A+++ + V+++L AVC+V G + +L+ +L A E +
Sbjct: 203 ESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQTLIN 262
Query: 326 IVE---GLRHNSVQLQVACMQLINALVTSP---DDLDFRLHIRNEFMRCGLKEILPNLKC 379
++ G + V L+ A M INA+++ + LDFRLH+R EF+ G++ ++ L+
Sbjct: 263 DLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLRE 322
Query: 380 IKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFIS 439
+N LD L F+ + ED E + R E + + A ++ + + + A +F+S
Sbjct: 323 HENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFMS 382
Query: 440 ILQHLLLI---RNDYFIRQQYFKLIDECVSQIVLHRD-GMDPDFTYRKRLDLDLTQFVDI 495
IL H L + R+ + QY+ L+D + QIV+ D G DPD T + + ++ V +
Sbjct: 383 ILHHCLQMPYKRSGNTV--QYWLLLDRIIQQIVIQNDKGQDPDSTPLE--NFNIKNVVRM 438
Query: 496 CIDQAKLEEFEEKASELYK-----------------------------------KFEKEF 520
+++ ++++++E+A ++ K K EKE
Sbjct: 439 LVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKET 498
Query: 521 TDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPP 580
T+H++ + ++ A+++EL G P P P S G S LPPPPP
Sbjct: 499 TEHKQVKQQVADLTAQLHELSRRAVCASIPGGPSPGAPGGPFPSSVPG----SLLPPPPP 554
Query: 581 LPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPP--PPPLGFLGGQNSPPLPILPFGLKPKK 638
P GG+ PPPPPP PP GP PP PPPLG + P P P GL KK
Sbjct: 555 PPLPGGMLPPPPPPLPP---------GGPPPPPGPPPLGAI-----MPPPGAPMGLALKK 600
Query: 639 EF--KPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKE---- 692
+ +P +++ NW K+ P E W ++++ K + L LE TF Q++
Sbjct: 601 KSIPQPTNALKSFNWSKL-PENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFF 659
Query: 693 ------RREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDE 746
++E + I++ S K K+KEL +D + AQN +I LS ++ +EI+ IL +DE
Sbjct: 660 VNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDE 719
Query: 747 TR-LAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILF 805
L + M++ L+K +P++ ++ L + K E + + ++F+ MS + + RL ++ F
Sbjct: 720 QEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYF 779
Query: 806 KLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLS 865
K +F E+V +KP + A+ + EE+ +S + +LLE+VL GNYMN G R +GF +S
Sbjct: 780 KKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQR-GNAYGFKIS 838
Query: 866 SLCKLKDTKSA-DQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQ 924
SL K+ DTKS+ D+ TLLH+L+ I E KYP +LN ++L + +A+KV++ L+K +
Sbjct: 839 SLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEIST 898
Query: 925 MGRQLQQLEKELE--TFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSII 982
+ L+ +E ELE PP+ DKFV+ +S+F+ A + + L + L+ +
Sbjct: 899 LRSGLKAVETELEYQKSQPPQP-GDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAV 957
Query: 983 GYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIK-KREAEEKEKRVRIAKELAERERLE 1041
++ + K+ ++F + F +A +EN +++ EE+E+R R+ +L E+ E
Sbjct: 958 KHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQRERE 1017
Query: 1042 RQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAF-RDRRKRTPMPKDVRQSLSPMS-QRP 1099
R+ +K K +E+G D+L+ AL+SG F +D K K + ++ S +RP
Sbjct: 1018 RKMRK-----AKENSEESGEFDDLVSALRSGEVFDKDLSKLKRNRKRITNQMTDSSRERP 1072
Query: 1100 VLKV 1103
+ K+
Sbjct: 1073 ITKL 1076
>gi|40548415 dishevelled associated activator of morphogenesis 2 [Homo
sapiens]
Length = 1067
Score = 392 bits (1007), Expect = e-108
Identities = 291/1034 (28%), Positives = 521/1034 (50%), Gaps = 94/1034 (9%)
Query: 106 PLEMMENFPKPLSENELLEL-FEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQ-YINTAS 163
PL+ ME F P+ E L + F +++++++L + RE F++ E Q Y +
Sbjct: 32 PLQFME-FSSPIPNAEELNIRFAELVDELDLTDKN----REAMFALPPEKKWQIYCSKKK 86
Query: 164 KTGSLKRSRQISPQEFIHELKMGSADERLVT-----------CLESLRVSLTSNPVSWVE 212
+ + P +I + +A + L +E L+ +L + P+ +V
Sbjct: 87 EQEDPNKLATSWPDYYIDRINSMAAMQSLYAFDEEETEMRNQVVEDLKTALRTQPMRFVT 146
Query: 213 SFGH-EGLGLLLDILEKLISGKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERSLS 271
F EGL LL+ L + + ++ +I C+KALMN G ++++ ++S
Sbjct: 147 RFIELEGLTCLLNFLRSMDHATCESRI----HTSLIGCIKALMNNSQGRAHVLAQPEAIS 202
Query: 272 LLAKAVDPRHPNMMTDVVKLLSAVCIV--GEESILEEVLEALTSAGEEKKIDRFFCIVE- 328
+A+++ + V+++L AVC+V G + +L+ +L A E + ++
Sbjct: 203 TIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVYAAERTRFQTLLNELDR 262
Query: 329 --GLRHNSVQLQVACMQLINALVTS---PDDLDFRLHIRNEFMRCGLKEILPNLKCIKND 383
G + V L+ A M INA++ + D+L+FRLH+R EF+ G++ ++ L+ +N
Sbjct: 263 SLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENA 322
Query: 384 GLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQH 443
LD L F+ + ED EL+ R + + + A ++ ++ +K T A +S+L H
Sbjct: 323 ILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKYTEAYPCLLSVLHH 382
Query: 444 LLLI---RNDYFIRQQYFKLIDECVSQIVLHRD-GMDPDFTYRKRLDLDLTQFVDICIDQ 499
L + RN + +Q ++L+D + QIVL + G+DPD + + ++ V++ I++
Sbjct: 383 CLQMPYKRNGGYFQQ--WQLLDRILQQIVLQDERGVDPDLAPLE--NFNVKNIVNMLINE 438
Query: 500 AKLEEFEEKASELYKKF--------------EKEFTDHQETQAELQKKEAKINELQAELQ 545
+++++ ++A + K+ E + + +E L K + K+ EL+
Sbjct: 439 NEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELR 498
Query: 546 AFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLP-------SGGGVPPPPPP----- 593
+ Q L A + E TG + PPPP P + +PPPPPP
Sbjct: 499 QARGQVAELVAQLS-------ELSTGPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFAC 551
Query: 594 ---PPPPPLPGMRMPFSGPVPP--PPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRR 648
PPPPPLP P P PP PP LG P P L+ K+ +P ++
Sbjct: 552 CPPPPPPPLP----PGGPPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQPSHPLKS 607
Query: 649 LNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKK 708
NW+K+ E W ++++ + + L E F Q+ ++E E+ +K
Sbjct: 608 FNWVKLN-EERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTEDIYLASRK 666
Query: 709 IKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETR-LAESMIQNLIKHLPDQEQL 767
+KEL +D + AQN I LS ++ EEIR IL++DE LA+ M++ L+K +P++ +
Sbjct: 667 VKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDI 726
Query: 768 NSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTAC 827
+ L + K E + ++F+ MS + + RL A+ FK +F+E++ KP + A+ A
Sbjct: 727 DLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLAS 786
Query: 828 EEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSA-DQKTTLLHFL 886
E+ +SK ++LE++L +GN+MN G R +GF ++SL K+ DTKS+ D+ +LLH+L
Sbjct: 787 RELVRSKRLRQMLEVILAIGNFMNKGQRGG-AYGFRVASLNKIADTKSSIDRNISLLHYL 845
Query: 887 VEICEEKYPDILNFVDDLEPLDKASKVSVETLEK---NLRQMGRQLQQLEKELETFPPPE 943
+ I E+ +PDILN +L+ L +A+KV++ LEK NLR+ R ++ LE + P
Sbjct: 846 IMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVLEYQRRQVREPS 905
Query: 944 DLHDKFVTKMSRFV-ISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLN 1002
DKFV MS F+ +S+ E +L+E +K ++++ + D K+ ++F +
Sbjct: 906 ---DKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHD-SKMQPDEFFGIFD 961
Query: 1003 NFRTTFMQAIKE-NIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGDETGV 1061
F F +A ++ +R EE+E+R R+ L E+ ER Q+++++L + +E G
Sbjct: 962 TFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGGE 1021
Query: 1062 MDNLLEALQSGAAF 1075
D+L+ AL+SG F
Sbjct: 1022 FDDLVSALRSGEVF 1035
>gi|119120861 formin-like 3 isoform 2 [Homo sapiens]
Length = 976
Score = 303 bits (777), Expect = 5e-82
Identities = 249/962 (25%), Positives = 453/962 (47%), Gaps = 116/962 (12%)
Query: 121 ELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQY----INTASKTGSLKRSRQISP 176
EL E F ++ MNL DK LR+ D K +++ + T K + P
Sbjct: 33 ELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDP 92
Query: 177 QEFIHELKMGSADERLVTCLESLRVSLTSNPVSWVESF---GHEGLGLLLDILE----KL 229
+ K + L L +SL +N + WV F ++GL +L+D L +
Sbjct: 93 S--VTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSV 150
Query: 230 ISGKIQEKVVKKNQ---------HKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPR 280
+ + + KN H I CL+A+MN QYG +MS +++ +A +++ +
Sbjct: 151 MYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNK 210
Query: 281 HPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEE-KKIDRFFCIVEGLRH--NSVQL 337
+P V++LL+AVC+V E +L A + E K++ RF ++E R+ +++
Sbjct: 211 NPRTKALVLELLAAVCLVRGGH--EIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDF 268
Query: 338 QVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKE 397
VACMQ IN +V S +D++FR+H++ EF + GL+E L + +++ L +Q++ +
Sbjct: 269 MVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAY----L 324
Query: 398 EDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQY 457
+++F++ LED + N+ V+E E + + + LL + N+ +R
Sbjct: 325 DNVFDVGGLLEDAETK--------NVALEKVEEL--EEHVSHLTEKLLDLENENMMR--- 371
Query: 458 FKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFEEKASE------ 511
+ E Q++ ++ ++E E S
Sbjct: 372 ---VAELEKQLLQREKELE------------------------SIKETYENTSHQVHTLR 404
Query: 512 -LYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNI--PLPPSKEG 568
L K+ E+ F + ++ E+ +E A + + G P+D ++ P PP +E
Sbjct: 405 RLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEE- 463
Query: 569 GTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLP 628
LP PPP P PP PPPPPPLP PP PPL G S L
Sbjct: 464 -----VLPLPPP-------PAPPLPPPPPPLPDK-------CPPAPPLP--GAAPSVVLT 502
Query: 629 ILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCC 688
+ ++ KK K + + NW ++P++++ F +E E++DL K E F
Sbjct: 503 VGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDL-DKFEELFKT 561
Query: 689 QQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETR 748
+ + + + K+ +K ++ L++ A+NL+I L EEI I D
Sbjct: 562 KAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQT 621
Query: 749 LAESMIQNLIKHLPDQEQLNSLSQFKSE---YSNLCEPEQFVVVMSNVKRLRPRLSAILF 805
L ++ L++ LP + ++ L Q++ E L ++F+++ S V+RL R++ + F
Sbjct: 622 LPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAF 681
Query: 806 KLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLS 865
F++ + + P + A+ A +K S+ ++LE++L +GNYMN+ R A +GF L
Sbjct: 682 LGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGA-VYGFKLQ 740
Query: 866 SLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQM 925
SL L DTKS D+K TLLHF+ +EKYPD+ NF +L ++KA+ VS+E + +++++
Sbjct: 741 SLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKEL 800
Query: 926 GRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYY 985
GR ++ + +E +HD V + F+ + + + + L + + E+ Y +++ Y+
Sbjct: 801 GRGMELIRREC-------SIHDNSV--LRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYF 851
Query: 986 AIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQK 1045
K F F ++ +A +EN +++ EE + ++A+E + + Q+
Sbjct: 852 GESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQR 911
Query: 1046 KK 1047
K
Sbjct: 912 NK 913
>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
Length = 1240
Score = 299 bits (766), Expect = 9e-81
Identities = 253/981 (25%), Positives = 450/981 (45%), Gaps = 106/981 (10%)
Query: 182 ELKMGSADERL---------VTCLESLRVSLTSNPVSWVESFGHE-GLGLLLDILEKLIS 231
E + SAD L V LR L + W+ F + GL LLL+ L +L
Sbjct: 27 EANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSG 86
Query: 232 GKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKL 291
+ Q + C++A+MN++ G+E I+S + + L++A+D + + V +L
Sbjct: 87 RGVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFEL 146
Query: 292 LSAVCIVGEES--ILEEVLEALTSAGEEKKIDRFFCIVEGLR-HNSVQLQVACMQLINAL 348
L+A+CI E + + L+ + ++ RF ++ L ++V V + +INA+
Sbjct: 147 LAALCIYSPEGHVLTLDALDHYKTVCSQQY--RFSIVMNELSGSDNVPYVVTLLSVINAV 204
Query: 349 VTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLE 408
+ P+DL R +RNEF+ L ++L L+ +++ L IQL+ F+E K ED EL
Sbjct: 205 ILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSG 264
Query: 409 DIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQI 468
+ ++ +V+ ++ V + +S+LQ LL + Q ++ ++ V++
Sbjct: 265 GV--DMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRA 322
Query: 469 VLHRDGMDPDFTYRKRLDLDLT--------------QFVDICIDQAKLEEFEEKASELYK 514
VL + T + ++ L+ + V +DQ++ + +
Sbjct: 323 VLLASDAQ-ECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKP 381
Query: 515 KFEK---------EFTDHQETQAELQKKEAKINELQAELQAFKSQFGALP---ADCNIPL 562
E E DH ++++ L+ + + E QA LP A+ P
Sbjct: 382 SVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPP 441
Query: 563 PPSKEGGTGHSALP---PPPPLPSGGGVPPPPPP-------------PPPPPLPGMRMPF 606
PP G ALP PPPPLP G + PP PP PPPPPLPG+ P
Sbjct: 442 PPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCP- 500
Query: 607 SGPVPPPPPL--GFLGGQNSPPLPILPFGLKP--------------------------KK 638
PPPPPL G G PP P+LP P ++
Sbjct: 501 ----PPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRR 556
Query: 639 EFKPEISMRRLNWLKIRPHEMTE-NCFWIKVNENKYENVDL-LCKLENTFCCQQKERREE 696
P + M++LNW K+ + E N W ++ E V+ +E F + +E
Sbjct: 557 VNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEP 616
Query: 697 EDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQN 756
+ + +K+ KE+ FLD+K + NL+IFL F+ EE+ MI D T+ +++
Sbjct: 617 TMVAPRA--RKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQ 674
Query: 757 LIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNI 816
L+K LP++ ++ +L F E + L + F +++ + + R+ +L ++ +
Sbjct: 675 LLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMV 734
Query: 817 KPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSA 876
+P V ACE + S+ +L+L +GN++N GS GF +S+L KL +TKS
Sbjct: 735 RPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQ 794
Query: 877 DQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKEL 936
+ TLLH ++E E+ +PD+L DLE +A+ +++E + ++L LE E
Sbjct: 795 QNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKL--LETER 852
Query: 937 ETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVED 996
+ ++ +++ ++ + + L +L E +E+ + + Y D +++S+ED
Sbjct: 853 KVSASVAEVQEQYTERLQASI----SAFRALDELFEAIEQKQRELADYLCEDAQQLSLED 908
Query: 997 FLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERE-RLERQQKKKRLLEMKTE 1055
+ + FR F++A+KEN ++E K +R + ++LAE E R R + K + + +
Sbjct: 909 TFSTMKAFRDLFLRALKENKDRKEQAAKAERRK--QQLAEEEARRPRGEDGKPVRKGPGK 966
Query: 1056 GDETGVMDNLLEALQSGAAFR 1076
+E V+D LL ++ G R
Sbjct: 967 QEEVCVIDALLADIRKGFQLR 987
>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
Length = 1249
Score = 299 bits (766), Expect = 9e-81
Identities = 253/981 (25%), Positives = 450/981 (45%), Gaps = 106/981 (10%)
Query: 182 ELKMGSADERL---------VTCLESLRVSLTSNPVSWVESFGHE-GLGLLLDILEKLIS 231
E + SAD L V LR L + W+ F + GL LLL+ L +L
Sbjct: 27 EANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSG 86
Query: 232 GKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKL 291
+ Q + C++A+MN++ G+E I+S + + L++A+D + + V +L
Sbjct: 87 RGVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFEL 146
Query: 292 LSAVCIVGEES--ILEEVLEALTSAGEEKKIDRFFCIVEGLR-HNSVQLQVACMQLINAL 348
L+A+CI E + + L+ + ++ RF ++ L ++V V + +INA+
Sbjct: 147 LAALCIYSPEGHVLTLDALDHYKTVCSQQY--RFSIVMNELSGSDNVPYVVTLLSVINAV 204
Query: 349 VTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLE 408
+ P+DL R +RNEF+ L ++L L+ +++ L IQL+ F+E K ED EL
Sbjct: 205 ILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSG 264
Query: 409 DIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQI 468
+ ++ +V+ ++ V + +S+LQ LL + Q ++ ++ V++
Sbjct: 265 GV--DMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRA 322
Query: 469 VLHRDGMDPDFTYRKRLDLDLT--------------QFVDICIDQAKLEEFEEKASELYK 514
VL + T + ++ L+ + V +DQ++ + +
Sbjct: 323 VLLASDAQ-ECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKP 381
Query: 515 KFEK---------EFTDHQETQAELQKKEAKINELQAELQAFKSQFGALP---ADCNIPL 562
E E DH ++++ L+ + + E QA LP A+ P
Sbjct: 382 SVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPP 441
Query: 563 PPSKEGGTGHSALP---PPPPLPSGGGVPPPPPP-------------PPPPPLPGMRMPF 606
PP G ALP PPPPLP G + PP PP PPPPPLPG+ P
Sbjct: 442 PPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCP- 500
Query: 607 SGPVPPPPPL--GFLGGQNSPPLPILPFGLKP--------------------------KK 638
PPPPPL G G PP P+LP P ++
Sbjct: 501 ----PPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRR 556
Query: 639 EFKPEISMRRLNWLKIRPHEMTE-NCFWIKVNENKYENVDL-LCKLENTFCCQQKERREE 696
P + M++LNW K+ + E N W ++ E V+ +E F + +E
Sbjct: 557 VNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEP 616
Query: 697 EDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQN 756
+ + +K+ KE+ FLD+K + NL+IFL F+ EE+ MI D T+ +++
Sbjct: 617 TMVAPRA--RKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQ 674
Query: 757 LIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNI 816
L+K LP++ ++ +L F E + L + F +++ + + R+ +L ++ +
Sbjct: 675 LLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMV 734
Query: 817 KPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSA 876
+P V ACE + S+ +L+L +GN++N GS GF +S+L KL +TKS
Sbjct: 735 RPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQ 794
Query: 877 DQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKEL 936
+ TLLH ++E E+ +PD+L DLE +A+ +++E + ++L LE E
Sbjct: 795 QNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKL--LETER 852
Query: 937 ETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVED 996
+ ++ +++ ++ + + L +L E +E+ + + Y D +++S+ED
Sbjct: 853 KVSASVAEVQEQYTERLQASI----SAFRALDELFEAIEQKQRELADYLCEDAQQLSLED 908
Query: 997 FLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERE-RLERQQKKKRLLEMKTE 1055
+ + FR F++A+KEN ++E K +R + ++LAE E R R + K + + +
Sbjct: 909 TFSTMKAFRDLFLRALKENKDRKEQAAKAERRK--QQLAEEEARRPRGEDGKPVRKGPGK 966
Query: 1056 GDETGVMDNLLEALQSGAAFR 1076
+E V+D LL ++ G R
Sbjct: 967 QEEVCVIDALLADIRKGFQLR 987
>gi|119120874 formin-like 3 isoform 1 [Homo sapiens]
Length = 1027
Score = 285 bits (730), Expect = 1e-76
Identities = 218/823 (26%), Positives = 402/823 (48%), Gaps = 94/823 (11%)
Query: 240 KKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVG 299
K + H I CL+A+MN QYG +MS +++ +A +++ ++P V++LL+AVC+V
Sbjct: 221 KDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVR 280
Query: 300 EESILEEVLEALTSAGEE-KKIDRFFCIVEGLRH--NSVQLQVACMQLINALVTSPDDLD 356
E +L A + E K++ RF ++E R+ +++ VACMQ IN +V S +D++
Sbjct: 281 GGH--EIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMN 338
Query: 357 FRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDE 416
FR+H++ EF + GL+E L + +++ L +Q++ + +++F++ LED +
Sbjct: 339 FRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAY----LDNVFDVGGLLEDAETK--- 391
Query: 417 AYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMD 476
N+ V+E E + + + LL + N+ +R + E Q++ ++
Sbjct: 392 -----NVALEKVEEL--EEHVSHLTEKLLDLENENMMR------VAELEKQLLQREKELE 438
Query: 477 PDFTYRKRLDLDLTQFVDICIDQAKLEEFEEKASE-------LYKKFEKEFTDHQETQAE 529
++E E S L K+ E+ F +
Sbjct: 439 ------------------------SIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPN 474
Query: 530 LQKKEAKINELQAELQAFKSQFGALPADCNI--PLPPSKEGGTGHSALPPPPPLPSGGGV 587
++ E+ +E A + + G P+D ++ P PP +E LP PPP
Sbjct: 475 VRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEE------VLPLPPP------- 521
Query: 588 PPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMR 647
P PP PPPPPPLP PP PPL G S L + ++ KK K + +
Sbjct: 522 PAPPLPPPPPPLPDK-------CPPAPPLP--GAAPSVVLTVGLSAIRIKKPIKTKFRLP 572
Query: 648 RLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKK 707
NW ++P++++ F +E E++DL K E F + + + + K+ +K
Sbjct: 573 VFNWTALKPNQISGTVFSELDDEKILEDLDL-DKFEELFKTKAQGPALDLICSKNKTAQK 631
Query: 708 KIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQL 767
++ L++ A+NL+I L EEI I D L ++ L++ LP + ++
Sbjct: 632 AASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEV 691
Query: 768 NSLSQFKSE---YSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVS 824
L Q++ E L ++F+++ S V+RL R++ + F F++ + + P + A+
Sbjct: 692 KLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAII 751
Query: 825 TACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLH 884
A +K S+ ++LE++L +GNYMN+ R A +GF L SL L DTKS D+K TLLH
Sbjct: 752 AASASVKSSQKLKQMLEIILALGNYMNSSKRGA-VYGFKLQSLDLLLDTKSTDRKMTLLH 810
Query: 885 FLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPED 944
F+ +EKYPD+ NF +L ++KA+ VS+E + +++++GR ++ + +E
Sbjct: 811 FIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRREC-------S 863
Query: 945 LHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNF 1004
+HD V + F+ + + + + L + + E+ Y +++ Y+ K F F
Sbjct: 864 IHDNSV--LRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRF 921
Query: 1005 RTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKK 1047
++ +A +EN +++ EE + ++A+E + + Q+ K
Sbjct: 922 IRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNK 964
>gi|52485606 formin-like 2 [Homo sapiens]
Length = 1092
Score = 272 bits (696), Expect = 1e-72
Identities = 219/853 (25%), Positives = 404/853 (47%), Gaps = 100/853 (11%)
Query: 240 KKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIV- 298
K + H I CL+A+MN QYG +MS +++ +A +++ ++P V++LL+AVC+V
Sbjct: 218 KDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVR 277
Query: 299 -GEESILEEVLEALTSAGEEKKIDRFFCIVEGLRH--NSVQLQVACMQLINALVTSPDDL 355
G E IL GE+++ ++ ++E R+ N++ VA MQ IN +V S +D+
Sbjct: 278 GGHEIILSAFDNFKEVCGEKQRFEK---LMEHFRNEDNNIDFMVASMQFINIVVHSVEDM 334
Query: 356 DFRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAE-- 413
+FR+H++ EF + GL E L LK ++D L +Q++ + +++F++ LED +
Sbjct: 335 NFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAY----LDNVFDVGALLEDAETKNA 390
Query: 414 ----LDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIV 469
++E + + + +++T E + ++ + R + ++ E
Sbjct: 391 ALERVEELEENISHLSEKLQDTENEA-----MSKIVELEKQLMQRNKELDVVRE------ 439
Query: 470 LHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFEEKASELYKKFEKEFTDHQETQAE 529
+++D T RK + + EE ++ S L KK + + Q T
Sbjct: 440 IYKDANTQVHTLRKMVK--------------EKEEAIQRQSTLEKKIHE--LEKQGTIKI 483
Query: 530 LQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLP------- 582
+K + I L S + A ++ P+ + PPPPPLP
Sbjct: 484 QKKGDGDIAILPVVASGTLSMGSEVVAGNSVG--PTMGAASSGPLPPPPPPLPPSSDTPE 541
Query: 583 ---SGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQN------SPPLPILP-- 631
+G PP PPPPPPPP P P P PPPPPL + +PPLP P
Sbjct: 542 TVQNGPVTPPMPPPPPPPPPP----PPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPL 597
Query: 632 --------------FGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVD 677
+K KK K + M NW+ ++P+++ F +E E+++
Sbjct: 598 PGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLN 657
Query: 678 LLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEI 737
+ + E F + + + ++K +K ++ L++ A+NL+I L +EI
Sbjct: 658 -VDEFEEIFKTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEI 716
Query: 738 RMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSE---YSNLCEPEQFVVVMSNVK 794
I D L ++ L++ LP + ++ L ++ E NL + ++F++ S ++
Sbjct: 717 CKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIE 776
Query: 795 RLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGS 854
RL +++ + F F E + + P + A+ A IK S+ K+LE++L +GNYMN+
Sbjct: 777 RLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSK 836
Query: 855 RNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVS 914
R A +GF L SL L DTKS D+K TLLH++ + +EKY + F ++L ++KA+ VS
Sbjct: 837 RGA-VYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVS 895
Query: 915 VETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENM 974
+E + +++++ R + ++E +HD T + F+++ + + + L +
Sbjct: 896 LENVLLDVKELQRGMDLTKREY-------TMHD-HNTLLKEFILNNEGKLKKLQDDAKIA 947
Query: 975 EKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKEL 1034
+ + ++ Y+ + K F F + QA +EN +++ E+ + ++L
Sbjct: 948 QDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQ-----ALMEKL 1002
Query: 1035 AERERLERQQKKK 1047
E+E L QQ K
Sbjct: 1003 LEQEALMEQQDPK 1015
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 243 bits (619), Expect = 1e-63
Identities = 276/1154 (23%), Positives = 482/1154 (41%), Gaps = 239/1154 (20%)
Query: 96 AFASSDCSAAPLEMMENFPKPLSE-----NELLELFEKMMEDMNLNEDKKAPLREKDFSI 150
A S++ A P P P + EL E F + + MNL DK L + D
Sbjct: 4 AAGSAEQPAGPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYDNEK 63
Query: 151 KKEMV---------------MQYINTASKTGSLKRSRQISPQEFIHELKMGSADERLVTC 195
K E++ +Q + + TG + SR+++ +++ L +
Sbjct: 64 KWELICDQERFQVKNPPAAYIQKLKSYVDTGGV--SRKVAA-DWMSNLGFKRRVQESTQV 120
Query: 196 LESLRVSLTSNPVSWVESFGHE---GLGLLLDIL-----------------------EKL 229
L L SL +N + WV+ F +E GL +LL+ L K
Sbjct: 121 LRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKP 180
Query: 230 ISGKIQE------KVVKKNQHKVIQ---------------------------CLKALMNT 256
+ +++ V K++H I+ CL+A+MN
Sbjct: 181 LEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNY 240
Query: 257 QYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIV--GEESILEEVLEALTSA 314
Q G +M+ ++ +A +++ ++P V++LL+AVC+V G + IL
Sbjct: 241 QSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVC 300
Query: 315 GEEKKIDRFFCIVEGLRH--NSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKE 372
GE+ + ++ ++E R+ +++ VACMQ IN +V S ++++FR+ ++ EF GL
Sbjct: 301 GEQHRFEK---LMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDL 357
Query: 373 ILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETR 432
L L+ ++D L +Q I+A LD +DV ++ T ET+
Sbjct: 358 YLERLRLTESDKLQVQ---------------------IQAYLDNIFDVGALLEDT--ETK 394
Query: 433 AEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQF 492
++L+H+ + Q+ L+ E + RD + L+ L+Q
Sbjct: 395 N-----AVLEHMEEL-------QEQVALLTERL------RDAENESMAKIAELEKQLSQ- 435
Query: 493 VDICIDQAKLEEFEEKASELYKKFEKEFTDHQE-----TQAELQKKEAKINELQAE--LQ 545
+ +LE E+ SE E E K+ EL+ + ++
Sbjct: 436 -----ARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIR 490
Query: 546 AFKSQFGAL-----------PADCNIPLPPSKEGGTGHSALP---------PPPP----- 580
+ A+ P+ + P P G P PPPP
Sbjct: 491 ILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPG 550
Query: 581 LPS----------------GGGVPPP---------PPPPPPPPLPGMRMPFSGPVPPPP- 614
LPS G PPP PPPPPPPP PG P P PPPP
Sbjct: 551 LPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPP 610
Query: 615 ----PLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNE 670
P LG ++S P G+K KK + + M LNW+ ++P ++T F +E
Sbjct: 611 PPGGPPDALGRRDSELGP----GVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDE 666
Query: 671 NKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSF 730
+ +D + E F + + + + K+ +K + +++ A+NL+I L
Sbjct: 667 KVLQELD-MSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKG 725
Query: 731 RVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSE---YSNLCEPEQFV 787
+ E I I D L ++ L++ LP + + + +++F+ E L E ++F+
Sbjct: 726 NLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFM 785
Query: 788 VVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMG 847
+ S + RL R++ + F F + + P + A+ A IK S ++LE+VL G
Sbjct: 786 LCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFG 845
Query: 848 NYMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPL 907
NYMN+ R A +GF L SL L + KS D+K TLLH+LV++ EKYP + F DL L
Sbjct: 846 NYMNSSKRGA-AYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFL 904
Query: 908 DKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETL 967
DKA VS++++ ++R + R L+ ++E F +D + F+ + + L
Sbjct: 905 DKAGSVSLDSVLADVRSLQRGLELTQRE---FVRQDD-----CMVLKEFLRANSPTMDKL 956
Query: 968 SKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIK-KREAEEKE- 1025
+ ++ ++S++ Y+ + K S F + + F + +A +E + K+EA +E
Sbjct: 957 LADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEA 1016
Query: 1026 -----------------KRVRIAKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEA 1068
K R +L L+R+Q+K+ L+ E D G +++++
Sbjct: 1017 GADTPGKGEPPAPKSPPKARRPQMDLI--SELKRRQQKEPLI---YESDRDGAIEDIITV 1071
Query: 1069 LQSGAAFRDRRKRT 1082
+++ KRT
Sbjct: 1072 IKTVPFTARTGKRT 1085
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 200 bits (509), Expect = 6e-51
Identities = 159/584 (27%), Positives = 264/584 (45%), Gaps = 77/584 (13%)
Query: 522 DHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGH-SALPPPPP 580
DH++ A LQ E + Q L P +IP PP G G S PP PP
Sbjct: 623 DHKDIHAALQPMEGMASNQQKALP---------PPPASIPPPPPLPSGLGSLSPAPPMPP 673
Query: 581 LPSGGGVPPPPPP---------------PPPPPLPGMRMPFS--GPVPPPPPLGFLGGQN 623
+ +G +PPPPPP PPPPPLP P + GP P PPP G
Sbjct: 674 VSAGPPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPGGPPPAPPPPGLA---- 729
Query: 624 SPPLPILPFGL-------KPKKEFKPEISMRRLNWLKIRPHEMTENC---FWIKVNENKY 673
PP P L FGL K +P M+ L W +I+ + ++N W + E
Sbjct: 730 PPPPPGLFFGLGSSSSQCPRKPAIEPSCPMKPLYWTRIQISDRSQNATPTLWDSLEEPDI 789
Query: 674 ENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVP 733
+ L + QQK++ E E+K +KK I K LD K +Q + I +SS +
Sbjct: 790 RDPSEFEYLFSKDTTQQKKKPLSETYEKKNKVKKII---KLLDGKRSQTVGILISSLHLE 846
Query: 734 YEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQF-----KSEYSNLCEPEQFVV 788
++I+ I VD++ + + L ++ +++L + ++ + E L +PEQF+
Sbjct: 847 MKDIQQAIFNVDDSVVDLETLAALYENRAQEDELVKIRKYYETSKEEELKLLDKPEQFLH 906
Query: 789 VMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGN 848
++ + R I+F+ F E + ++ + ++ A +++ KS +L L+L GN
Sbjct: 907 ELAQIPNFAERAQCIIFRSVFSEGITSLHRKVEIITRASKDLLHVKSVKDILALILAFGN 966
Query: 849 YMNAGSR-NAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPL 907
YMN G+R Q G++L L KLKD KS D L+ ++V+ Y + PL
Sbjct: 967 YMNGGNRTRGQADGYSLEILPKLKDVKSRDNGINLVDYVVKYYLRYYDQEAGTEKSVFPL 1026
Query: 908 DK------ASKVSVETLEKNLRQMGRQLQQLEKELETF--PPPEDLHDKFVTKMSRFVIS 959
+ AS+V E L K+LR++ RQL+ EK++ P++ F K+ F
Sbjct: 1027 PEPQDFFLASQVKFEDLIKDLRKLKRQLEASEKQMVVVCKESPKEYLQPFKDKLEEFFQK 1086
Query: 960 AKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVE---------------DFLT----D 1000
AK++++ EN +K +++ + Y+ + K E DF T +
Sbjct: 1087 AKKEHKMEESHLENAQKSFETTVRYFGMKPKSGEKEITPSYVFMVWYEFCSDFKTIWKRE 1146
Query: 1001 LNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQ 1044
N ++ +E++ K +E+K + +I + +ERL +++
Sbjct: 1147 SKNISKERLKMAQESVSKLTSEKKVETKKINPTASLKERLRQKE 1190
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 184 bits (468), Expect = 3e-46
Identities = 132/461 (28%), Positives = 226/461 (49%), Gaps = 49/461 (10%)
Query: 587 VPPPP-PPPPPPPLP------------GMRMP----------FSGPVPPPPPLGFLGGQN 623
+PPPP PPPPPPLP G R P S PVPPPPP
Sbjct: 749 IPPPPLSPPPPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPPL----- 803
Query: 624 SPPLPILP----FGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENK-YENVDL 678
PP+P P GL ++ +S++RL W ++ E +E W ++ E+ Y+ +
Sbjct: 804 PPPVPCAPPMLSRGLGHRRSETSHMSVKRLRWEQV---ENSEGTIWGQLGEDSDYDKLSD 860
Query: 679 LCK---LENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYE 735
+ K LE F Q+ + + + +KK + ++ L K A N SI L+ ++
Sbjct: 861 MVKYLDLELHFGTQKPAK----PVPGPEPFRKK-EVVEILSHKKAYNTSILLAHLKLSPA 915
Query: 736 EIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKR 795
E+R +++ ++ RL + + L+ PD ++ F+ L EP+QFV+ M +V
Sbjct: 916 ELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPE 975
Query: 796 LRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGS- 854
+ RL ++ F+ +E+ I+ + + A E+K S+ +K+LE VL MGNY+N G
Sbjct: 976 YKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQP 1035
Query: 855 RNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVS 914
+ +T GF ++ L +L TK+ D K+T LH L + + +P++L F DL + A+KV+
Sbjct: 1036 KTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVN 1095
Query: 915 VETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKL-HEN 973
L +L + + +++ ++ P + DKF MS F+ +A+ L L E
Sbjct: 1096 QRALTSDLADLHGTISEIQDACQSISPSSE--DKFAMVMSSFLETAQPALRALDGLQREA 1153
Query: 974 MEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKE 1014
ME+L ++ + ++ D K + E F F + F +A+ +
Sbjct: 1154 MEELGKA-LAFFGEDSKATTSEAFFGIFAEFMSKFERALSD 1193
Score = 32.0 bits (71), Expect = 3.6
Identities = 30/103 (29%), Positives = 41/103 (39%), Gaps = 15/103 (14%)
Query: 554 LPADCNIPL------PPSKEGGTGHSALPP---PPPLPSGGGVPPPPPPPPPPPLPGMR- 603
LP+ C PL PS +++L P P P G + P PP P P P R
Sbjct: 606 LPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPPSPDPTRPPSRR 665
Query: 604 --MPFSGPVPPPPP---LGFLGGQNSPPLPILPFGLKPKKEFK 641
FS PV L L Q P + I+ L P+ +++
Sbjct: 666 KLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTPENDYE 708
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 180 bits (457), Expect = 6e-45
Identities = 153/581 (26%), Positives = 253/581 (43%), Gaps = 103/581 (17%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPP-----PPPPLPGMRMPFSGP----- 609
IP PP G + +PPPPPLP G G+PPPPP P PPPPLPG+ +P P
Sbjct: 1151 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAG 1205
Query: 610 VPPPPPLGFLG------------GQNSPPLPILP-------------------------- 631
+PPPPPL +G G PP P+LP
Sbjct: 1206 IPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPP 1265
Query: 632 ------FGL-------KPKKEFKPEISMRRLNWLKIRPH---EMTENCFWIKVNENKYEN 675
FGL K+ +P M+ L W +I+ H + + + W K+ E +
Sbjct: 1266 PLPSGLFGLGMNQDKGSRKQPIEPCRPMKPLYWTRIQLHSKRDSSTSLIWEKIEEPSID- 1324
Query: 676 VDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYE 735
C + + ++ I + S K + +K L +K +Q + I +SS + +
Sbjct: 1325 ----CHEFEELFSKTAVKERKKPISDTISKTKAKQVVKLLSNKRSQAVGILMSSLHLDMK 1380
Query: 736 EIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSL------SQFKSEYSNLCEPEQFVVV 789
+I+ ++ +D + + +Q L ++ ++L + S+ K +L +PEQF+
Sbjct: 1381 DIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYE 1440
Query: 790 MSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNY 849
+S + R+ ILF+ F E + +I+ + + CE +K ++L LVL GNY
Sbjct: 1441 LSLIPNFSERVFCILFQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNY 1500
Query: 850 MNAGSR-NAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLD 908
MN G++ Q GF L L KLKD KS+D +LL ++V + + L PL
Sbjct: 1501 MNGGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLP 1560
Query: 909 ------KASKVSVETLEKNLRQMGRQLQQLEKEL-ETFPPPEDLH-DKFVTKMSRFVISA 960
+AS++ E +K+LR++ + L+ E E + + H F M +F+I A
Sbjct: 1561 EPQDLFQASQMKFEDFQKDLRKLKKDLKACEVEAGKVYQVSSKEHMQPFKENMEQFIIQA 1620
Query: 961 KEQYETLSKLHENMEKLYQSIIGYY----AIDVKKVSVEDFLTDLNNFRTTFMQAIKENI 1016
K E K + Y+ + K+VS F + + F + F
Sbjct: 1621 KIDQEAEENSLTETHKCFLETTAYFFMKPKLGEKEVSPNAFFSIWHEFSSDF-------- 1672
Query: 1017 KKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGD 1057
++ +KE ++ + + + E E + RQ+K K L ++K D
Sbjct: 1673 --KDFWKKENKLLLQERVKEAEEVCRQKKGKSLYKIKPRHD 1711
Score = 75.5 bits (184), Expect = 3e-13
Identities = 41/79 (51%), Positives = 46/79 (58%), Gaps = 15/79 (18%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 609
IPLPP G + +PPPPPLP G G+PPPPP PPPPPLPG +P P
Sbjct: 964 IPLPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1018
Query: 610 VPPPPPLGFLGGQNSPPLP 628
+PPPPPL G PPLP
Sbjct: 1019 IPPPPPLPGAGIPPPPPLP 1037
Score = 73.6 bits (179), Expect = 1e-12
Identities = 40/79 (50%), Positives = 46/79 (58%), Gaps = 15/79 (18%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 609
IP PP G + +PPPPPLP G G+PPPPP PPPPPLPG+ +P P
Sbjct: 1063 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAG 1117
Query: 610 VPPPPPLGFLGGQNSPPLP 628
+PPPPPL G PPLP
Sbjct: 1118 IPPPPPLPGAGIPPPPPLP 1136
Score = 72.8 bits (177), Expect = 2e-12
Identities = 40/79 (50%), Positives = 45/79 (56%), Gaps = 15/79 (18%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 609
IP PP G + +PPPPPLP G G+PPPPP PPPPPLPG +P P
Sbjct: 997 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1051
Query: 610 VPPPPPLGFLGGQNSPPLP 628
+PPPPPL G PPLP
Sbjct: 1052 IPPPPPLPGAGIPPPPPLP 1070
Score = 72.8 bits (177), Expect = 2e-12
Identities = 40/79 (50%), Positives = 45/79 (56%), Gaps = 15/79 (18%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 609
IP PP G + +PPPPPLP G G+PPPPP PPPPPLPG +P P
Sbjct: 1030 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1084
Query: 610 VPPPPPLGFLGGQNSPPLP 628
+PPPPPL G PPLP
Sbjct: 1085 IPPPPPLPGAGIPPPPPLP 1103
Score = 72.8 bits (177), Expect = 2e-12
Identities = 40/79 (50%), Positives = 45/79 (56%), Gaps = 15/79 (18%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 609
IP PP G + +PPPPPLP G G+PPPPP PPPPPLPG +P P
Sbjct: 1074 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAG 1128
Query: 610 VPPPPPLGFLGGQNSPPLP 628
+PPPPPL G PPLP
Sbjct: 1129 IPPPPPLPGAGIPPPPPLP 1147
Score = 71.6 bits (174), Expect = 4e-12
Identities = 40/79 (50%), Positives = 44/79 (55%), Gaps = 15/79 (18%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 609
IP PP G +PPPPPLP G G+PPPPP PPPPPLPG +P P
Sbjct: 1096 IPPPPPLPG----VGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVG 1150
Query: 610 VPPPPPLGFLGGQNSPPLP 628
+PPPPPL G PPLP
Sbjct: 1151 IPPPPPLPGAGIPPPPPLP 1169
Score = 70.5 bits (171), Expect = 9e-12
Identities = 40/79 (50%), Positives = 45/79 (56%), Gaps = 15/79 (18%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----PPPPPPLPGMRMPFSGP----- 609
IP PP G +A+PPPPPLP G G+P PPP PPPPPLPG +P P
Sbjct: 942 IPPPPPLPG----AAIPPPPPLP-GAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 996
Query: 610 VPPPPPLGFLGGQNSPPLP 628
+PPPPPL G PPLP
Sbjct: 997 IPPPPPLPGAGIPPPPPLP 1015
Score = 67.4 bits (163), Expect = 8e-11
Identities = 38/79 (48%), Positives = 42/79 (53%), Gaps = 13/79 (16%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPP-----PPPPLPGMRMPFSGP----- 609
IP PP +G LPPPPP G G+PPPPP P P PPLPG +P P
Sbjct: 896 IPQPPPLQGT---EMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAA 952
Query: 610 VPPPPPLGFLGGQNSPPLP 628
+PPPPPL G PPLP
Sbjct: 953 IPPPPPLPGAGIPLPPPLP 971
Score = 66.2 bits (160), Expect = 2e-10
Identities = 38/79 (48%), Positives = 44/79 (55%), Gaps = 15/79 (18%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 609
IP PP G + +PPPPPLP G G+PPPPP PPPP P G+ P P
Sbjct: 1041 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1095
Query: 610 VPPPPPLGFLGGQNSPPLP 628
+PPPPPL +G PPLP
Sbjct: 1096 IPPPPPLPGVGIPPPPPLP 1114
Score = 65.9 bits (159), Expect = 2e-10
Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 609
IP PP G + +PPPPPLP G G+PPPPP PPPP P G+ P P
Sbjct: 1107 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAG 1161
Query: 610 VPPPPPLGFLGGQNSPPLP 628
+PPPPPL G PPLP
Sbjct: 1162 IPPPPPLPGAGIPPPPPLP 1180
Score = 65.5 bits (158), Expect = 3e-10
Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 609
IP PP G + +PPPPPLP G G+PPPPP PPPP P G+ P P
Sbjct: 975 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1029
Query: 610 VPPPPPLGFLGGQNSPPLP 628
+PPPPPL G PPLP
Sbjct: 1030 IPPPPPLPGAGIPPPPPLP 1048
Score = 65.5 bits (158), Expect = 3e-10
Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 609
IP PP G + +PPPPPLP G G+PPPPP PPPP P G+ P P
Sbjct: 986 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1040
Query: 610 VPPPPPLGFLGGQNSPPLP 628
+PPPPPL G PPLP
Sbjct: 1041 IPPPPPLPGAGIPPPPPLP 1059
Score = 65.5 bits (158), Expect = 3e-10
Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 609
IP PP G + +PPPPPLP G G+PPPPP PPPP P G+ P P
Sbjct: 1008 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1062
Query: 610 VPPPPPLGFLGGQNSPPLP 628
+PPPPPL G PPLP
Sbjct: 1063 IPPPPPLPGAGIPPPPPLP 1081
Score = 65.5 bits (158), Expect = 3e-10
Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 609
IP PP G + +PPPPPLP G G+PPPPP PPPP P G+ P P
Sbjct: 1019 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1073
Query: 610 VPPPPPLGFLGGQNSPPLP 628
+PPPPPL G PPLP
Sbjct: 1074 IPPPPPLPGAGIPPPPPLP 1092
Score = 65.5 bits (158), Expect = 3e-10
Identities = 38/79 (48%), Positives = 43/79 (54%), Gaps = 15/79 (18%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 609
IP PP G + +PPPPPLP G G+PPPPP PPPP P G+ P P
Sbjct: 1052 IPPPPPLPG----AGIPPPPPLP-GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVG 1106
Query: 610 VPPPPPLGFLGGQNSPPLP 628
+PPPPPL G PPLP
Sbjct: 1107 IPPPPPLPGAGIPPPPPLP 1125
Score = 65.1 bits (157), Expect = 4e-10
Identities = 38/79 (48%), Positives = 44/79 (55%), Gaps = 15/79 (18%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------PPPPPPLPGMRMPFSGP--- 609
IP PP G + +PPPPPLP G G+PPPPP PPPP P G+ P P
Sbjct: 1085 IPPPPPLPG----AGIPPPPPLP-GVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1139
Query: 610 VPPPPPLGFLGGQNSPPLP 628
+PPPPPL +G PPLP
Sbjct: 1140 IPPPPPLPRVGIPPPPPLP 1158
Score = 63.9 bits (154), Expect = 9e-10
Identities = 38/89 (42%), Positives = 44/89 (49%), Gaps = 23/89 (25%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPSGG----------GVPPPPP-------PPPPPPLPGM 602
+P PP G G +PPPPPLP G G+PPPPP PPPP P G+
Sbjct: 908 LPPPPPPLPGAG---IPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGI 964
Query: 603 RMPFSGP---VPPPPPLGFLGGQNSPPLP 628
+P P +PPPPPL G PPLP
Sbjct: 965 PLPPPLPGAGIPPPPPLPGAGIPPPPPLP 993
Score = 62.4 bits (150), Expect = 2e-09
Identities = 41/98 (41%), Positives = 44/98 (44%), Gaps = 29/98 (29%)
Query: 553 ALPADCNIPLPP------SKEGGTGHSALPPPPP---------LPSGGGVPPPPP----- 592
A CNIP PP S G +PPPPP LPS +P PPP
Sbjct: 848 AFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPS-TAIPQPPPLQGTE 906
Query: 593 --PPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLP 628
PPPPPPLPG +PPPPPL G PPLP
Sbjct: 907 MLPPPPPPLPG------AGIPPPPPLPGAGILPLPPLP 938
Score = 61.2 bits (147), Expect = 6e-09
Identities = 38/85 (44%), Positives = 43/85 (50%), Gaps = 16/85 (18%)
Query: 554 LPADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPP-------PPPPLPGMRMPF 606
LP +PLPP G +PPPPPLP G +PPPPP P PP P G+ P
Sbjct: 926 LPGAGILPLPPLPGAG-----IPPPPPLP-GAAIPPPPPLPGAGIPLPPPLPGAGIPPPP 979
Query: 607 SGP---VPPPPPLGFLGGQNSPPLP 628
P +PPPPPL G PPLP
Sbjct: 980 PLPGAGIPPPPPLPGAGIPPPPPLP 1004
Score = 51.2 bits (121), Expect = 6e-06
Identities = 29/68 (42%), Positives = 34/68 (50%), Gaps = 6/68 (8%)
Query: 575 LPPPPPLPSGGGVPPPPP----PPPPPPLPGMRMPF--SGPVPPPPPLGFLGGQNSPPLP 628
+P PPPLP P PPPPPPLPGM +P S +P PPPL PP P
Sbjct: 855 IPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPP 914
Query: 629 ILPFGLKP 636
+ G+ P
Sbjct: 915 LPGAGIPP 922
>gi|145309324 FH2 domain containing 1 [Homo sapiens]
Length = 1143
Score = 179 bits (454), Expect = 1e-44
Identities = 133/485 (27%), Positives = 218/485 (44%), Gaps = 43/485 (8%)
Query: 578 PPPLPSGGGVPPPPPPPPPPPLPGMR--MPFSGPVPPPPPLGFLGGQNSPPLPILPFGLK 635
PPP P PPPPPPPP PP R P S P PPPPPL PP+P P GL
Sbjct: 30 PPPAPP----PPPPPPPPSPPCSCSREECPSSPPPPPPPPL-----PGEPPIPPPPPGLP 80
Query: 636 PKKEFK------PEISMRRLNWLKIRPHEMTE---NCFWIKVNENKYENVDLLCKLENTF 686
P + MR W I P E N + + + + +D +E F
Sbjct: 81 PTTHMNGYSHLGKKKRMRSFFWKTI-PEEQVRGKTNIWTLAARQEHHYQIDTKT-IEELF 138
Query: 687 CCQQ---KERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILE 743
Q+ K S ++ +E+ LD+K + N+ IFL F+ I I +
Sbjct: 139 GQQEDTTKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQFKKSPRSIVEDIHQ 198
Query: 744 VDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAI 803
++ +K LP+ E++ L F + S L + F+ + V R+ A+
Sbjct: 199 GKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGLIQVPNYSLRIEAM 258
Query: 804 LFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFN 863
+ K +F +++ DI + TA +E+ + +L LVL GN MNAG GF
Sbjct: 259 VLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAVGFK 318
Query: 864 LSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLR 923
LSSL KL DTK+ LLHF+ + ++K +LNF + L + K +++S+E E L
Sbjct: 319 LSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEAELH 378
Query: 924 QMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIG 983
+ + + L++ ++ + +M F+ A E+ L + ++ ++I
Sbjct: 379 LLFVRTKSLKENIQR-------DGELCQQMEDFLQFAIEKLRELECWKQELQDEAYTLID 431
Query: 984 YYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQ 1043
++ D K + +++ +F T F +A+K+N R A+EL + +RL+ Q
Sbjct: 432 FFCEDKKTMKLDECFQIFRDFCTKFNKAVKDN-----------HDREAQELRQLQRLKEQ 480
Query: 1044 QKKKR 1048
++K+R
Sbjct: 481 EQKQR 485
>gi|58331242 formin homology 2 domain containing 3 [Homo sapiens]
Length = 1439
Score = 155 bits (391), Expect = 3e-37
Identities = 119/472 (25%), Positives = 220/472 (46%), Gaps = 46/472 (9%)
Query: 576 PPPPPLPSGGGVPPPPPPP-----PPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPIL 630
PPPPP P+ G+PPPPPPP PPPP+PG + VPPPP G +P
Sbjct: 846 PPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLL-----VPPPPVFNAPQGLGWSQVP-- 898
Query: 631 PFGLKPKKEFKPEISMRRLNWLKIRPHEM----TENC---FWIKVNENKYENVDLLCKLE 683
+ + F + RL W ++RP + C W K+ K + +LE
Sbjct: 899 ----RGQPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKVDT----SRLE 950
Query: 684 NTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILE 743
+ F + + +E + +K + K +E+ LDSK + ++I L+ P I++ IL
Sbjct: 951 HLF----ESKSKELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPP-RTIKIAILN 1005
Query: 744 VDETRLAESMIQNLIKHLPDQEQLNSL--SQFKSEYSNLCEPEQFVVVMSNVKRLRPRLS 801
DE L + I+ ++ +P E+ + +Q + L EQF++ +S++ L RL
Sbjct: 1006 FDEYALNKEGIEKILTMIPTDEEKQKIQEAQLANPEIPLGSAEQFLLTLSSISELSARLH 1065
Query: 802 AILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFG 861
FK+ +E + ++ + ++++ +K+ +L +L +GN++N + A
Sbjct: 1066 LWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKA---- 1121
Query: 862 FNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKN 921
F LS L K+ + K K +LLH + + E +PD + ++ + +++KV + L+ N
Sbjct: 1122 FELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDN 1181
Query: 922 LRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSI 981
L QM R+ + L+ E + +MS F+ E+ L +H + + S
Sbjct: 1182 LCQMERRCKASWDHLKAIAKHE-MKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSF 1240
Query: 982 I---GYYAIDVKKVSVEDFLTDLNNF----RTTFMQAIKENIKKREAEEKEK 1026
+ G+ +++V++ F ++ F RTT + +++ K+ E+ K
Sbjct: 1241 LLFMGHPPYAIREVNINKFCRIISEFALEYRTTRERVLQQKQKRANHRERNK 1292
>gi|118572599 formin homology 2 domain containing 1 [Homo sapiens]
Length = 1164
Score = 139 bits (350), Expect = 2e-32
Identities = 113/480 (23%), Positives = 218/480 (45%), Gaps = 48/480 (10%)
Query: 577 PPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKP 636
P PPLP GVPPPPP PPPPP+ GP PPPPPL P LP +
Sbjct: 572 PSPPLPLLSGVPPPPPLPPPPPI-------KGPFPPPPPL--------PLAAPLPHSVPD 616
Query: 637 KKEFKPEISMRRLNWLKIR---PHEMTENCF------WIKVNENKYENVDLLCKLENTFC 687
+ +L W +++ H ++ + F W ++ + +LE+ F
Sbjct: 617 SSALPTKRKTVKLFWRELKLAGGHGVSASRFGPCATLWASLDPVSVDT----ARLEHLF- 671
Query: 688 CQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDET 747
E R +E + KK+ + + LD K + ++I L++ P I+ +L DE
Sbjct: 672 ----ESRAKEVLPSKKAGEGRRTMTTVLDPKRSNAINIGLTTL-PPVHVIKAALLNFDEF 726
Query: 748 RLAESMIQNLIKHLPDQEQLNSL--SQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILF 805
+++ I+ L+ +P +E+ + +Q + L E F++ ++++ L RL F
Sbjct: 727 AVSKDGIEKLLTMMPTEEERQKIEEAQLANPDIPLGPAENFLMTLASIGGLAARLQLWAF 786
Query: 806 KLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLS 865
KL ++ I + + E++ ++ +F +L +L +GN++N +Q+ GF LS
Sbjct: 787 KLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLN----GSQSSGFELS 842
Query: 866 SLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQM 925
L K+ + K ++ +LLH L + + P+ + ++ L + +KV E L +NL Q+
Sbjct: 843 YLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQL 902
Query: 926 GRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSI---I 982
R+ + E+ L + E L +++ F+ + L +H + + + +
Sbjct: 903 ERRSRAAEESLRSLAKHE-LAPALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYL 961
Query: 983 GYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENI---KKREAEEKEKRVRIAKELAERER 1039
GY ++V + F L F + + +E + ++++A +E+ + + E E+
Sbjct: 962 GYTPQAAREVRIMQFCHTLREFALEY-RTCRERVLQQQQKQATYRERNKTRGRMITETEK 1020
>gi|14249316 hypothetical protein LOC84800 [Homo sapiens]
Length = 234
Score = 70.5 bits (171), Expect = 9e-12
Identities = 57/210 (27%), Positives = 102/210 (48%), Gaps = 15/210 (7%)
Query: 182 ELKMGSADERL---------VTCLESLRVSLTSNPVSWVESFGHE-GLGLLLDILEKLIS 231
E + SAD L V LR L + W+ F + GL LLL+ L +L
Sbjct: 27 EANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSG 86
Query: 232 GKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKL 291
+ Q + C++A+MN++ G+E I+S + + L++A+D + + V +L
Sbjct: 87 RGVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFEL 146
Query: 292 LSAVCIVGEES--ILEEVLEALTSAGEEKKIDRFFCIVEGLR-HNSVQLQVACMQLINAL 348
L+A+CI E + + L+ + ++ RF ++ L ++V V + +INA+
Sbjct: 147 LAALCIYSPEGHVLTLDALDHYKTVCSQQY--RFSIVMNELSGSDNVPYVVTLLSVINAV 204
Query: 349 VTSPDDLDFRLHIRNEFMRCGLKEILPNLK 378
+ P+DL R +RNEF+ L ++L L+
Sbjct: 205 ILGPEDLRARTQLRNEFIGLQLLDVLARLR 234
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 69.7 bits (169), Expect = 2e-11
Identities = 52/162 (32%), Positives = 70/162 (43%), Gaps = 32/162 (19%)
Query: 499 QAKLEEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKS-QFGALPAD 557
Q +LE E E ++ E+E + E + + ++++ ++ Q E + + A PA
Sbjct: 213 QERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPAS 272
Query: 558 CNIPL----------------------PPSKEGGT-GHSALPPPPPLPSGG-----GVPP 589
PL PS++G G A PPPPPLP G +PP
Sbjct: 273 VETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPP 332
Query: 590 PPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILP 631
PP PPPPPPLP P P PPPPPL PP P P
Sbjct: 333 PPGPPPPPPLPSTGPP---PPPPPPPLPNQVPPPPPPPPAPP 371
Score = 61.6 bits (148), Expect = 4e-09
Identities = 37/85 (43%), Positives = 41/85 (48%), Gaps = 23/85 (27%)
Query: 555 PADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPP 614
PA ++ LPP PPPPPLPS G PPPPPPPPP +P P PPPP
Sbjct: 323 PAQASVALPPPP-------GPPPPPPLPSTG--PPPPPPPPP-------LPNQVPPPPPP 366
Query: 615 PLGFLGGQNSPPLPILPFGLKPKKE 639
P +PPLP F L E
Sbjct: 367 P-------PAPPLPASGFFLASMSE 384
Score = 33.1 bits (74), Expect = 1.6
Identities = 18/49 (36%), Positives = 30/49 (61%)
Query: 1010 QAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGDE 1058
Q KE ++R E+ +R R+ +E ERERLER++ ++ LE + + E
Sbjct: 151 QRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERE 199
Score = 32.3 bits (72), Expect = 2.8
Identities = 12/36 (33%), Positives = 27/36 (75%)
Query: 1016 IKKREAEEKEKRVRIAKELAERERLERQQKKKRLLE 1051
I++R+ +E++++ + +E ERER+ER++ ++ LE
Sbjct: 142 IQRRQLQEQQRQKELERERLERERMERERLERERLE 177
Score = 31.6 bits (70), Expect = 4.7
Identities = 16/43 (37%), Positives = 30/43 (69%), Gaps = 1/43 (2%)
Query: 1012 IKENIKKREAE-EKEKRVRIAKELAERERLERQQKKKRLLEMK 1053
++E +++E E E+ +R R+ +E ERERLER++ ++ LE +
Sbjct: 147 LQEQQRQKELERERLERERMERERLERERLERERLERERLEQE 189
Score = 30.8 bits (68), Expect = 8.0
Identities = 12/39 (30%), Positives = 28/39 (71%)
Query: 1013 KENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLE 1051
+ +++++ +++ +R R+ +E ERERLER++ ++ LE
Sbjct: 144 RRQLQEQQRQKELERERLERERMERERLERERLERERLE 182
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 69.7 bits (169), Expect = 2e-11
Identities = 52/162 (32%), Positives = 70/162 (43%), Gaps = 32/162 (19%)
Query: 499 QAKLEEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKS-QFGALPAD 557
Q +LE E E ++ E+E + E + + ++++ ++ Q E + + A PA
Sbjct: 213 QERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPAS 272
Query: 558 CNIPL----------------------PPSKEGGT-GHSALPPPPPLPSGG-----GVPP 589
PL PS++G G A PPPPPLP G +PP
Sbjct: 273 VETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPP 332
Query: 590 PPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILP 631
PP PPPPPPLP P P PPPPPL PP P P
Sbjct: 333 PPGPPPPPPLPSTGPP---PPPPPPPLPNQVPPPPPPPPAPP 371
Score = 61.6 bits (148), Expect = 4e-09
Identities = 37/85 (43%), Positives = 41/85 (48%), Gaps = 23/85 (27%)
Query: 555 PADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPP 614
PA ++ LPP PPPPPLPS G PPPPPPPPP +P P PPPP
Sbjct: 323 PAQASVALPPPP-------GPPPPPPLPSTG--PPPPPPPPP-------LPNQVPPPPPP 366
Query: 615 PLGFLGGQNSPPLPILPFGLKPKKE 639
P +PPLP F L E
Sbjct: 367 P-------PAPPLPASGFFLASMSE 384
Score = 33.1 bits (74), Expect = 1.6
Identities = 18/49 (36%), Positives = 30/49 (61%)
Query: 1010 QAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGDE 1058
Q KE ++R E+ +R R+ +E ERERLER++ ++ LE + + E
Sbjct: 151 QRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERE 199
Score = 32.3 bits (72), Expect = 2.8
Identities = 12/36 (33%), Positives = 27/36 (75%)
Query: 1016 IKKREAEEKEKRVRIAKELAERERLERQQKKKRLLE 1051
I++R+ +E++++ + +E ERER+ER++ ++ LE
Sbjct: 142 IQRRQLQEQQRQKELERERLERERMERERLERERLE 177
Score = 31.6 bits (70), Expect = 4.7
Identities = 16/43 (37%), Positives = 30/43 (69%), Gaps = 1/43 (2%)
Query: 1012 IKENIKKREAE-EKEKRVRIAKELAERERLERQQKKKRLLEMK 1053
++E +++E E E+ +R R+ +E ERERLER++ ++ LE +
Sbjct: 147 LQEQQRQKELERERLERERMERERLERERLERERLERERLEQE 189
Score = 30.8 bits (68), Expect = 8.0
Identities = 12/39 (30%), Positives = 28/39 (71%)
Query: 1013 KENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLE 1051
+ +++++ +++ +R R+ +E ERERLER++ ++ LE
Sbjct: 144 RRQLQEQQRQKELERERLERERMERERLERERLERERLE 182
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 67.0 bits (162), Expect = 1e-10
Identities = 40/91 (43%), Positives = 43/91 (47%), Gaps = 4/91 (4%)
Query: 556 ADCNIPL--PPSKEGGTGHSALPPPPPLPSGGGVPP-PPPPPPPPPLPGMRMPFSGPVPP 612
ADC P+ P S L P PLP G PP PPPPPPPPP PG MP P PP
Sbjct: 654 ADCPKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPP 713
Query: 613 PPPLGFLGGQNSPPLPI-LPFGLKPKKEFKP 642
PPP PP P+ P G+ P P
Sbjct: 714 PPPPPAHPAVTVPPPPLPAPPGVPPPPILPP 744
Score = 62.8 bits (151), Expect = 2e-09
Identities = 37/80 (46%), Positives = 39/80 (48%), Gaps = 7/80 (8%)
Query: 560 IPLPPSKEGGTGHSALPPPPPLPS---GGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPL 616
+PLPP G LPPPPP P G +PPP PPPPPPP P P P P P
Sbjct: 679 LPLPPPP----GFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPP 734
Query: 617 GFLGGQNSPPLPILPFGLKP 636
G PPLP P GL P
Sbjct: 735 GVPPPPILPPLPPFPPGLFP 754
Score = 47.0 bits (110), Expect = 1e-04
Identities = 22/46 (47%), Positives = 26/46 (56%), Gaps = 13/46 (28%)
Query: 577 PPPPLPSGGGVPPPPPPPPPPPLPGMRMPF--------SGPVPPPP 614
PPPPLP P PPPPPPPPP+ ++PF S +PP P
Sbjct: 1539 PPPPLP-----PQPPPPPPPPPVEPTKLPFKELDNQWPSEAIPPGP 1579
Score = 37.0 bits (84), Expect = 0.11
Identities = 27/71 (38%), Positives = 31/71 (43%), Gaps = 10/71 (14%)
Query: 561 PLPPSKEGGTGHSALPPPP---PLPSGGGVPPPPPP--PPPPPLPGMRMPFSGPVPPPPP 615
PL P + P PP PLP +PPP PP P PPP P S P PP P
Sbjct: 1253 PLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEP-ETTDASHPSVPPEP 1311
Query: 616 LGFLGGQNSPP 626
L ++ PP
Sbjct: 1312 L----AEDHPP 1318
Score = 36.6 bits (83), Expect = 0.15
Identities = 27/86 (31%), Positives = 32/86 (37%), Gaps = 14/86 (16%)
Query: 562 LPPSKEGGTGHSALPP----PPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVP--PPPP 615
LP GGTG S+ PP P + PPP P P P+ PV PPPP
Sbjct: 352 LPFGAVGGTGGSSGPPFKAQPQDSATFAHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPP 411
Query: 616 LGFLGGQNSPPLPILPFGLKPKKEFK 641
P FG + EF+
Sbjct: 412 --------EEPTATAAFGARDSGEFR 429
Score = 36.6 bits (83), Expect = 0.15
Identities = 23/62 (37%), Positives = 27/62 (43%), Gaps = 12/62 (19%)
Query: 586 GVPPPPPPPPPPPLPGMRMPFSGPVPPPP----PLGFLGGQNSPPLPILPFGLKPKKEFK 641
G+P PPPP PP P P P PPPP L F N P +P G + + E
Sbjct: 1535 GIPAPPPPLPPQPPP--------PPPPPPVEPTKLPFKELDNQWPSEAIPPGPRGRDEVT 1586
Query: 642 PE 643
E
Sbjct: 1587 EE 1588
Score = 33.5 bits (75), Expect = 1.2
Identities = 19/51 (37%), Positives = 21/51 (41%), Gaps = 13/51 (25%)
Query: 576 PPPPPLPSGGGV------------PPPPPPPPPPPLPGMRMPFSGPVPPPP 614
PPPP P+ P PPP PP PL P + P PPPP
Sbjct: 408 PPPPEEPTATAAFGARDSGEFRRAPAPPPLPPAEPL-AKEKPGTPPGPPPP 457
Score = 32.7 bits (73), Expect = 2.1
Identities = 24/72 (33%), Positives = 27/72 (37%), Gaps = 3/72 (4%)
Query: 561 PLPPSKEGGTGHSALPPPPPLPSGGGVPPPP---PPPPPPPLPGMRMPFSGPVPPPPPLG 617
P PP+KE P P P PP P P PPLP R P PP P
Sbjct: 1241 PEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETT 1300
Query: 618 FLGGQNSPPLPI 629
+ PP P+
Sbjct: 1301 DASHPSVPPEPL 1312
Score = 31.6 bits (70), Expect = 4.7
Identities = 26/84 (30%), Positives = 30/84 (35%), Gaps = 17/84 (20%)
Query: 547 FKSQFGALPAD-CNIPLPPSKEGGTG---------HSALPPPPPLPSGGGV----PPPPP 592
FKS F + P PP + T P PPPLP + P PP
Sbjct: 393 FKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSGEFRRAPAPPPLPPAEPLAKEKPGTPP 452
Query: 593 PPPPPPLPGMRM---PFSGPVPPP 613
PPPP M + P G P P
Sbjct: 453 GPPPPDTNSMELGGRPTFGWSPEP 476
Score = 31.6 bits (70), Expect = 4.7
Identities = 23/72 (31%), Positives = 25/72 (34%), Gaps = 14/72 (19%)
Query: 555 PADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPP-----------PPPPPPLPGMR 603
PAD P G L P PP PP P P PP LP
Sbjct: 1219 PADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLP--- 1275
Query: 604 MPFSGPVPPPPP 615
+P P+PPP P
Sbjct: 1276 LPLQPPLPPPRP 1287
Score = 31.2 bits (69), Expect = 6.1
Identities = 26/90 (28%), Positives = 38/90 (42%), Gaps = 11/90 (12%)
Query: 520 FTDHQETQAELQKKEAKINELQAELQAFKSQFG--ALPADCNIPLPPSKEGGTGHSALPP 577
F ++ ELQ + + I+ ++L + FG + P P S+ TG + P
Sbjct: 516 FLREPDSDTELQMEGSPISSSSSQLSPL-APFGTNSQPGFRGPTPPSSRPSSTGLEDISP 574
Query: 578 PPPLPSGG-------GVPPPPPPPPPPPLP 600
P LP G+ P PPP P PP P
Sbjct: 575 TP-LPDSDEDEELDLGLGPRPPPEPGPPDP 603
Score = 30.8 bits (68), Expect = 8.0
Identities = 21/62 (33%), Positives = 24/62 (38%), Gaps = 14/62 (22%)
Query: 557 DCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPP-PLPGMRMPFSGPVPPPPP 615
+ IP PP LPP PP P PPPPP P P + + PP P
Sbjct: 1533 NAGIPAPPPP--------LPPQPPPP-----PPPPPVEPTKLPFKELDNQWPSEAIPPGP 1579
Query: 616 LG 617
G
Sbjct: 1580 RG 1581
>gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]
Length = 502
Score = 63.2 bits (152), Expect = 1e-09
Identities = 30/54 (55%), Positives = 32/54 (59%), Gaps = 6/54 (11%)
Query: 563 PPSKEGGTGHSA-LPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPP 615
PP TG S LPPPPP G +PPPPPPPPPPP G +GP PPP P
Sbjct: 368 PPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSG-----NGPAPPPLP 416
Score = 62.0 bits (149), Expect = 3e-09
Identities = 41/106 (38%), Positives = 43/106 (40%), Gaps = 27/106 (25%)
Query: 560 IPLPPSKEGGTGHSA--------LPPPPPLPSG------GGVPPPPPP---------PPP 596
+P PP G G S + PPPP P G GG PPPPPP PPP
Sbjct: 326 LPRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPPPPGRGGPPPPPPPATGRSGPLPPPP 385
Query: 597 PPLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKP 642
P G MP P PPPPP N P P LP L P P
Sbjct: 386 PGAGGPPMPPPPPPPPPPP----SSGNGPAPPPLPPALVPAGGLAP 427
Score = 60.8 bits (146), Expect = 7e-09
Identities = 47/138 (34%), Positives = 55/138 (39%), Gaps = 44/138 (31%)
Query: 521 TDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALP---- 576
++ Q T AE K E Q L+A + + PLPP G + LP
Sbjct: 277 SEAQLTDAETSKLIYDFIEDQGGLEAVRQEMRRQE-----PLPPPPPPSRGGNQLPRPPI 331
Query: 577 -------------------PPPPLPSGGGVPPPP----PPPPPPPLPGMRMPFSGPVPPP 613
PPPP P G PPPP PPPPPPP G SGP+PPP
Sbjct: 332 VGGNKGRSGPLPPVPLGIAPPPPTPRG---PPPPGRGGPPPPPPPATGR----SGPLPPP 384
Query: 614 PPLGFLGGQNSPPLPILP 631
PP G PP+P P
Sbjct: 385 PP-----GAGGPPMPPPP 397
>gi|183396804 Regulation of nuclear pre-mRNA domain containing 2 [Homo
sapiens]
Length = 1461
Score = 62.8 bits (151), Expect = 2e-09
Identities = 33/75 (44%), Positives = 39/75 (52%), Gaps = 3/75 (4%)
Query: 563 PPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPP---PPLPGMRMPFSGPVPPPPPLGFL 619
P +KE H+A PPPP SG P PPPPPPP G +PFS P PPPPP+
Sbjct: 1243 PFTKEAALAHAAPPPPPGEHSGIPFPTPPPPPPPGEHSSSGGSGVPFSTPPPPPPPVDHS 1302
Query: 620 GGQNSPPLPILPFGL 634
G P P+ G+
Sbjct: 1303 GVVPFPAPPLAEHGV 1317
Score = 48.1 bits (113), Expect = 5e-05
Identities = 28/62 (45%), Positives = 30/62 (48%), Gaps = 11/62 (17%)
Query: 561 PLPPSKEGGTGHSALPPPPP-----LPSGGGVPPPPPPPPPPPLPGMRMPFSGPVP-PPP 614
P PP + G PPPPP G GVP PPPPPPP + SG VP P P
Sbjct: 1256 PPPPGEHSGIPFPTPPPPPPPGEHSSSGGSGVPFSTPPPPPPP-----VDHSGVVPFPAP 1310
Query: 615 PL 616
PL
Sbjct: 1311 PL 1312
>gi|11386183 WAS protein family, member 2 [Homo sapiens]
Length = 498
Score = 60.5 bits (145), Expect = 9e-09
Identities = 38/96 (39%), Positives = 42/96 (43%), Gaps = 14/96 (14%)
Query: 557 DCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPL 616
D P PP + LPPPP GG PPPPPPPPPP PPPPP
Sbjct: 360 DFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPG------------PPPPPF 407
Query: 617 GFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWL 652
GQ + P P L KPK P +S R + L
Sbjct: 408 TGADGQPAIP-PPLSDTTKPKSSL-PAVSDARSDLL 441
Score = 59.7 bits (143), Expect = 2e-08
Identities = 32/73 (43%), Positives = 37/73 (50%), Gaps = 13/73 (17%)
Query: 564 PSKEGGTGHSALPPPPPL-----PSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGF 618
P + S PP PPL P G PPP PPPPPPP+ G+ PPPPP+GF
Sbjct: 289 PKRSSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGI-------PPPPPPVGF 341
Query: 619 LGGQNSPPLPILP 631
G +PP P P
Sbjct: 342 -GSPGTPPPPSPP 353
Score = 53.5 bits (127), Expect = 1e-06
Identities = 35/99 (35%), Positives = 37/99 (37%), Gaps = 28/99 (28%)
Query: 563 PPSKEGGTGHSALPPPPPLPSGGGVPPPPP-------------------------PPPPP 597
PP + G PPPPP P G PPPPP PPPPP
Sbjct: 309 PPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPPPP 368
Query: 598 PLPGMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKP 636
P P P +PPPP GG PP P P G P
Sbjct: 369 PPPAADYP---TLPPPPLSQPTGGAPPPPPPPPPPGPPP 404
Score = 42.4 bits (98), Expect = 0.003
Identities = 30/76 (39%), Positives = 32/76 (42%), Gaps = 12/76 (15%)
Query: 561 PLPP--SKEGGTGHSALPPPPPLPSGGGVPPPPPP---PPPPPLPGMRMPFSGPVPPPPP 615
P PP S G A PP PP PPPPP PPPPP G P + P P PP
Sbjct: 302 PAPPLGSPPGPKPGFAPPPAPP-------PPPPPMIGIPPPPPPVGFGSPGTPPPPSPPS 354
Query: 616 LGFLGGQNSPPLPILP 631
+PP P P
Sbjct: 355 FPPHPDFAAPPPPPPP 370
>gi|149944526 additional sex combs like 3 [Homo sapiens]
Length = 2248
Score = 58.5 bits (140), Expect = 4e-08
Identities = 57/194 (29%), Positives = 84/194 (43%), Gaps = 46/194 (23%)
Query: 559 NIPLPPSKE-GGTGHSALPPPPPLPSGGGV-PPPPPPPPPPPLPGMRMPFSGPVPPPPPL 616
N+P+ E GGT H+ +P+ V PPPPPPPPPPP P + P PPPPP
Sbjct: 1993 NMPMKEGDEVGGTAHT-------MPNKALVHPPPPPPPPPPP------PLALPPPPPPP- 2038
Query: 617 GFLGGQNSPPL-PILPFGLKPKKEFKPEISM---RRLNWLKIRPHEMTENCFWIKVNENK 672
PPL P LP P + +P ++M +RL+W + T C IK
Sbjct: 2039 --------PPLPPPLPNAEVPSDQKQPPVTMETTKRLSW-----PQSTGICSNIKSEPLS 2085
Query: 673 YENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRV 732
+E + C+ ++ D E K ++LK K A S LS +
Sbjct: 2086 FEE-------GLSSSCELGMKQVSYDQNEMK------EQLKAFALKSADFSSYLLSEPQK 2132
Query: 733 PYEEIRMMILEVDE 746
P+ ++ ++V +
Sbjct: 2133 PFTQLAAQKMQVQQ 2146
>gi|10937869 survival of motor neuron 2, centromeric isoform d [Homo
sapiens]
Length = 294
Score = 58.2 bits (139), Expect = 5e-08
Identities = 35/99 (35%), Positives = 52/99 (52%), Gaps = 16/99 (16%)
Query: 532 KKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSG------- 584
++ A+ NE ++++ +S+ P + + + P + +S LPPPPP+P
Sbjct: 153 EQNAQENENESQVSTDESENSRSPGNKSDNIKP--KSAPWNSFLPPPPPMPGPRLGPGKP 210
Query: 585 ----GGVPPPPPPPPPPPLPGMRMPF-SGP--VPPPPPL 616
G PPPPPPPPP L PF SGP +PPPPP+
Sbjct: 211 GLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPI 249
Score = 33.5 bits (75), Expect = 1.2
Identities = 29/94 (30%), Positives = 33/94 (35%), Gaps = 21/94 (22%)
Query: 521 TDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLP---PSKEGGTGHSALPP 577
TD E K I A +F LP +P P P K G + PP
Sbjct: 167 TDESENSRSPGNKSDNIKPKSAPWNSF------LPPPPPMPGPRLGPGKPGLKFNGPPPP 220
Query: 578 PPP------------LPSGGGVPPPPPPPPPPPL 599
PPP PSG + PPPPP P L
Sbjct: 221 PPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSL 254
>gi|13259527 survival of motor neuron 2, centromeric isoform a [Homo
sapiens]
Length = 282
Score = 58.2 bits (139), Expect = 5e-08
Identities = 35/99 (35%), Positives = 52/99 (52%), Gaps = 16/99 (16%)
Query: 532 KKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSG------- 584
++ A+ NE ++++ +S+ P + + + P + +S LPPPPP+P
Sbjct: 153 EQNAQENENESQVSTDESENSRSPGNKSDNIKP--KSAPWNSFLPPPPPMPGPRLGPGKP 210
Query: 585 ----GGVPPPPPPPPPPPLPGMRMPF-SGP--VPPPPPL 616
G PPPPPPPPP L PF SGP +PPPPP+
Sbjct: 211 GLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPI 249
Score = 33.5 bits (75), Expect = 1.2
Identities = 29/94 (30%), Positives = 33/94 (35%), Gaps = 21/94 (22%)
Query: 521 TDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLP---PSKEGGTGHSALPP 577
TD E K I A +F LP +P P P K G + PP
Sbjct: 167 TDESENSRSPGNKSDNIKPKSAPWNSF------LPPPPPMPGPRLGPGKPGLKFNGPPPP 220
Query: 578 PPP------------LPSGGGVPPPPPPPPPPPL 599
PPP PSG + PPPPP P L
Sbjct: 221 PPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSL 254
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,443,654
Number of Sequences: 37866
Number of extensions: 3089747
Number of successful extensions: 73053
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 876
Number of HSP's successfully gapped in prelim test: 1062
Number of HSP's that attempted gapping in prelim test: 29778
Number of HSP's gapped (non-prelim): 21377
length of query: 1193
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1079
effective length of database: 13,930,794
effective search space: 15031326726
effective search space used: 15031326726
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.