Guide to the Human Genome
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Search of human proteins with 110224456

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|110224456 solute carrier family 12, member 6 isoform d [Homo
sapiens]
         (1141 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|110224456 solute carrier family 12, member 6 isoform d [Homo ...  2271   0.0  
gi|110224449 solute carrier family 12, member 6 isoform a [Homo ...  2271   0.0  
gi|110224458 solute carrier family 12, member 6 isoform e [Homo ...  2232   0.0  
gi|110224454 solute carrier family 12, member 6 isoform c [Homo ...  2176   0.0  
gi|110224452 solute carrier family 12, member 6 isoform c [Homo ...  2176   0.0  
gi|4826780 solute carrier family 12, member 6 isoform b [Homo sa...  2118   0.0  
gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa...  1669   0.0  
gi|225579065 solute carrier family 12, member 4 isoform d [Homo ...  1665   0.0  
gi|225579067 solute carrier family 12, member 4 isoform e [Homo ...  1664   0.0  
gi|225579061 solute carrier family 12, member 4 isoform b [Homo ...  1652   0.0  
gi|225579063 solute carrier family 12, member 4 isoform c [Homo ...  1641   0.0  
gi|198041678 solute carrier family 12 (potassium-chloride transp...  1555   0.0  
gi|11968148 solute carrier family 12 (potassium-chloride transpo...  1555   0.0  
gi|123701900 solute carrier family 12 (potassium/chloride transp...  1512   0.0  
gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo ...   239   1e-62
gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo ...   236   1e-61
gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo ...   236   1e-61
gi|4506975 solute carrier family 12 (sodium/potassium/chloride t...   223   1e-57
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap...   211   2e-54
gi|31881740 solute carrier family 12 (potassium/chloride transpo...   195   2e-49
gi|38569457 solute carrier family 12, member 8 [Homo sapiens]         104   4e-22
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s...    47   1e-04
gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo s...    46   2e-04
gi|4507047 solute carrier family 7 (cationic amino acid transpor...    40   0.010
gi|9790235 solute carrier family 7, member 10 [Homo sapiens]           37   0.082
gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi...    36   0.18 
gi|195927037 DNA (cytosine-5-)-methyltransferase 1 isoform a [Ho...    36   0.18 
gi|4503351 DNA (cytosine-5-)-methyltransferase 1 isoform b [Homo...    36   0.18 
gi|181337167 solute carrier family 7 (cationic amino acid transp...    36   0.18 
gi|114326550 solute carrier family 7 (cationic amino acid transp...    35   0.31 

>gi|110224456 solute carrier family 12, member 6 isoform d [Homo
            sapiens]
          Length = 1141

 Score = 2271 bits (5884), Expect = 0.0
 Identities = 1141/1141 (100%), Positives = 1141/1141 (100%)

Query: 1    MASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTS 60
            MASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTS
Sbjct: 1    MASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTS 60

Query: 61   LATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYF 120
            LATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYF
Sbjct: 61   LATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYF 120

Query: 121  DKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFM 180
            DKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFM
Sbjct: 121  DKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFM 180

Query: 181  GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 240
            GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA
Sbjct: 181  GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 240

Query: 241  GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 300
            GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK
Sbjct: 241  GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 300

Query: 301  ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAP 360
            ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAP
Sbjct: 301  ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAP 360

Query: 361  PHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNV 420
            PHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNV
Sbjct: 361  PHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNV 420

Query: 421  TSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLV 480
            TSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLV
Sbjct: 421  TSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLV 480

Query: 481  GIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRD 540
            GIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRD
Sbjct: 481  GIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRD 540

Query: 541  KFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRV 600
            KFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRV
Sbjct: 541  KFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRV 600

Query: 601  FGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRT 660
            FGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRT
Sbjct: 601  FGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRT 660

Query: 661  PNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDG 720
            PNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDG
Sbjct: 661  PNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDG 720

Query: 721  IRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGL 780
            IRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGL
Sbjct: 721  IRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGL 780

Query: 781  TIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLG 840
            TIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLG
Sbjct: 781  TIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLG 840

Query: 841  GMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEG 900
            GMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEG
Sbjct: 841  GMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEG 900

Query: 901  NIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRI 960
            NIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRI
Sbjct: 901  NIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRI 960

Query: 961  EAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTS 1020
            EAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTS
Sbjct: 961  EAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTS 1020

Query: 1021 IGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVK 1080
            IGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVK
Sbjct: 1021 IGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVK 1080

Query: 1081 LNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIY 1140
            LNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIY
Sbjct: 1081 LNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIY 1140

Query: 1141 S 1141
            S
Sbjct: 1141 S 1141


>gi|110224449 solute carrier family 12, member 6 isoform a [Homo
            sapiens]
          Length = 1150

 Score = 2271 bits (5884), Expect = 0.0
 Identities = 1141/1141 (100%), Positives = 1141/1141 (100%)

Query: 1    MASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTS 60
            MASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTS
Sbjct: 10   MASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTS 69

Query: 61   LATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYF 120
            LATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYF
Sbjct: 70   LATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYF 129

Query: 121  DKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFM 180
            DKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFM
Sbjct: 130  DKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFM 189

Query: 181  GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 240
            GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA
Sbjct: 190  GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 249

Query: 241  GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 300
            GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK
Sbjct: 250  GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 309

Query: 301  ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAP 360
            ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAP
Sbjct: 310  ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAP 369

Query: 361  PHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNV 420
            PHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNV
Sbjct: 370  PHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNV 429

Query: 421  TSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLV 480
            TSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLV
Sbjct: 430  TSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLV 489

Query: 481  GIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRD 540
            GIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRD
Sbjct: 490  GIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRD 549

Query: 541  KFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRV 600
            KFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRV
Sbjct: 550  KFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRV 609

Query: 601  FGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRT 660
            FGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRT
Sbjct: 610  FGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRT 669

Query: 661  PNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDG 720
            PNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDG
Sbjct: 670  PNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDG 729

Query: 721  IRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGL 780
            IRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGL
Sbjct: 730  IRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGL 789

Query: 781  TIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLG 840
            TIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLG
Sbjct: 790  TIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLG 849

Query: 841  GMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEG 900
            GMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEG
Sbjct: 850  GMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEG 909

Query: 901  NIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRI 960
            NIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRI
Sbjct: 910  NIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRI 969

Query: 961  EAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTS 1020
            EAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTS
Sbjct: 970  EAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTS 1029

Query: 1021 IGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVK 1080
            IGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVK
Sbjct: 1030 IGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVK 1089

Query: 1081 LNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIY 1140
            LNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIY
Sbjct: 1090 LNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIY 1149

Query: 1141 S 1141
            S
Sbjct: 1150 S 1150


>gi|110224458 solute carrier family 12, member 6 isoform e [Homo
            sapiens]
          Length = 1135

 Score = 2232 bits (5784), Expect = 0.0
 Identities = 1126/1141 (98%), Positives = 1126/1141 (98%), Gaps = 15/1141 (1%)

Query: 1    MASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTS 60
            MASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTS
Sbjct: 10   MASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTS 69

Query: 61   LATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYF 120
            LATVALDPPSDRTSHPQDVIED               DGHKKARNAYLNNSNYEEGDEYF
Sbjct: 70   LATVALDPPSDRTSHPQDVIED---------------DGHKKARNAYLNNSNYEEGDEYF 114

Query: 121  DKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFM 180
            DKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFM
Sbjct: 115  DKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFM 174

Query: 181  GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 240
            GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA
Sbjct: 175  GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 234

Query: 241  GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 300
            GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK
Sbjct: 235  GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 294

Query: 301  ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAP 360
            ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAP
Sbjct: 295  ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAP 354

Query: 361  PHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNV 420
            PHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNV
Sbjct: 355  PHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNV 414

Query: 421  TSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLV 480
            TSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLV
Sbjct: 415  TSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLV 474

Query: 481  GIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRD 540
            GIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRD
Sbjct: 475  GIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRD 534

Query: 541  KFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRV 600
            KFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRV
Sbjct: 535  KFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRV 594

Query: 601  FGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRT 660
            FGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRT
Sbjct: 595  FGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRT 654

Query: 661  PNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDG 720
            PNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDG
Sbjct: 655  PNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDG 714

Query: 721  IRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGL 780
            IRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGL
Sbjct: 715  IRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGL 774

Query: 781  TIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLG 840
            TIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLG
Sbjct: 775  TIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLG 834

Query: 841  GMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEG 900
            GMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEG
Sbjct: 835  GMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEG 894

Query: 901  NIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRI 960
            NIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRI
Sbjct: 895  NIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRI 954

Query: 961  EAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTS 1020
            EAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTS
Sbjct: 955  EAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTS 1014

Query: 1021 IGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVK 1080
            IGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVK
Sbjct: 1015 IGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVK 1074

Query: 1081 LNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIY 1140
            LNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIY
Sbjct: 1075 LNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIY 1134

Query: 1141 S 1141
            S
Sbjct: 1135 S 1135


>gi|110224454 solute carrier family 12, member 6 isoform c [Homo
            sapiens]
          Length = 1091

 Score = 2176 bits (5639), Expect = 0.0
 Identities = 1091/1091 (100%), Positives = 1091/1091 (100%)

Query: 51   MSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNN 110
            MSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNN
Sbjct: 1    MSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNN 60

Query: 111  SNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP 170
            SNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP
Sbjct: 61   SNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP 120

Query: 171  TKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMS 230
            TKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMS
Sbjct: 121  TKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMS 180

Query: 231  AIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRA 290
            AIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRA
Sbjct: 181  AIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRA 240

Query: 291  AIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIY 350
            AIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIY
Sbjct: 241  AIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIY 300

Query: 351  AGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNAT 410
            AGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNAT
Sbjct: 301  AGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNAT 360

Query: 411  CDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLV 470
            CDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLV
Sbjct: 361  CDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLV 420

Query: 471  DITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG 530
            DITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG
Sbjct: 421  DITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG 480

Query: 531  ACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA 590
            ACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA
Sbjct: 481  ACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA 540

Query: 591  KDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNL 650
            KDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNL
Sbjct: 541  KDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNL 600

Query: 651  ACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEY 710
            ACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEY
Sbjct: 601  ACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEY 660

Query: 711  QGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTF 770
            QGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTF
Sbjct: 661  QGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTF 720

Query: 771  ASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGI 830
            ASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGI
Sbjct: 721  ASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGI 780

Query: 831  SHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFF 890
            SHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFF
Sbjct: 781  SHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFF 840

Query: 891  PSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKD 950
            PSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKD
Sbjct: 841  PSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKD 900

Query: 951  LATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVK 1010
            LATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVK
Sbjct: 901  LATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVK 960

Query: 1011 DRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQS 1070
            DRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQS
Sbjct: 961  DRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQS 1020

Query: 1071 NVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVR 1130
            NVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVR
Sbjct: 1021 NVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVR 1080

Query: 1131 GGGSEVITIYS 1141
            GGGSEVITIYS
Sbjct: 1081 GGGSEVITIYS 1091


>gi|110224452 solute carrier family 12, member 6 isoform c [Homo
            sapiens]
          Length = 1091

 Score = 2176 bits (5639), Expect = 0.0
 Identities = 1091/1091 (100%), Positives = 1091/1091 (100%)

Query: 51   MSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNN 110
            MSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNN
Sbjct: 1    MSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNN 60

Query: 111  SNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP 170
            SNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP
Sbjct: 61   SNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP 120

Query: 171  TKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMS 230
            TKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMS
Sbjct: 121  TKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMS 180

Query: 231  AIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRA 290
            AIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRA
Sbjct: 181  AIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRA 240

Query: 291  AIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIY 350
            AIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIY
Sbjct: 241  AIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIY 300

Query: 351  AGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNAT 410
            AGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNAT
Sbjct: 301  AGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNAT 360

Query: 411  CDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLV 470
            CDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLV
Sbjct: 361  CDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLV 420

Query: 471  DITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG 530
            DITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG
Sbjct: 421  DITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG 480

Query: 531  ACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA 590
            ACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA
Sbjct: 481  ACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA 540

Query: 591  KDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNL 650
            KDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNL
Sbjct: 541  KDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNL 600

Query: 651  ACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEY 710
            ACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEY
Sbjct: 601  ACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEY 660

Query: 711  QGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTF 770
            QGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTF
Sbjct: 661  QGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTF 720

Query: 771  ASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGI 830
            ASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGI
Sbjct: 721  ASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGI 780

Query: 831  SHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFF 890
            SHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFF
Sbjct: 781  SHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFF 840

Query: 891  PSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKD 950
            PSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKD
Sbjct: 841  PSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKD 900

Query: 951  LATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVK 1010
            LATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVK
Sbjct: 901  LATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVK 960

Query: 1011 DRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQS 1070
            DRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQS
Sbjct: 961  DRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQS 1020

Query: 1071 NVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVR 1130
            NVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVR
Sbjct: 1021 NVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVR 1080

Query: 1131 GGGSEVITIYS 1141
            GGGSEVITIYS
Sbjct: 1081 GGGSEVITIYS 1091


>gi|4826780 solute carrier family 12, member 6 isoform b [Homo
            sapiens]
          Length = 1099

 Score = 2118 bits (5487), Expect = 0.0
 Identities = 1066/1082 (98%), Positives = 1072/1082 (99%), Gaps = 2/1082 (0%)

Query: 62   ATVALDPP-SDRTSHPQDVIE-DLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEY 119
            A+++ +P  +D  +  QD  E DLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEY
Sbjct: 18   ASISQEPSLADIKARIQDSDEPDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEY 77

Query: 120  FDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTF 179
            FDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTF
Sbjct: 78   FDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTF 137

Query: 180  MGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVP 239
            MGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVP
Sbjct: 138  MGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVP 197

Query: 240  AGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDAL 299
            AGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDAL
Sbjct: 198  AGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDAL 257

Query: 300  KESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFA 359
            KESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFA
Sbjct: 258  KESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFA 317

Query: 360  PPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNN 419
            PPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNN
Sbjct: 318  PPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNN 377

Query: 420  VTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLL 479
            VTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLL
Sbjct: 378  VTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLL 437

Query: 480  VGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLR 539
            VGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLR
Sbjct: 438  VGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLR 497

Query: 540  DKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLR 599
            DKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLR
Sbjct: 498  DKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLR 557

Query: 600  VFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLR 659
            VFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLR
Sbjct: 558  VFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLR 617

Query: 660  TPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGD 719
            TPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGD
Sbjct: 618  TPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGD 677

Query: 720  GIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKG 779
            GIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKG
Sbjct: 678  GIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKG 737

Query: 780  LTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGL 839
            LTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGL
Sbjct: 738  LTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGL 797

Query: 840  GGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSE 899
            GGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSE
Sbjct: 798  GGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSE 857

Query: 900  GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLR 959
            GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLR
Sbjct: 858  GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLR 917

Query: 960  IEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLT 1019
            IEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLT
Sbjct: 918  IEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLT 977

Query: 1020 SIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAV 1079
            SIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAV
Sbjct: 978  SIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAV 1037

Query: 1080 KLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITI 1139
            KLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITI
Sbjct: 1038 KLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITI 1097

Query: 1140 YS 1141
            YS
Sbjct: 1098 YS 1099


>gi|4827006 solute carrier family 12, member 4 isoform a [Homo
            sapiens]
          Length = 1085

 Score = 1669 bits (4321), Expect = 0.0
 Identities = 827/1058 (78%), Positives = 931/1058 (87%), Gaps = 7/1058 (0%)

Query: 90   GEHSQLLD-DGHKKARNA--YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMAN 146
            GE ++L D DGH   R +  +L+      G +Y+D+NLALFEEE+D RPKVSSLL ++ +
Sbjct: 29   GERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVS 88

Query: 147  YTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTA 206
            YTNLTQGAKEHEEAE+    +++  + P MGT MGVYLPCLQNIFGVILFLRLTW+VGTA
Sbjct: 89   YTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTA 148

Query: 207  GVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLG 266
            GVLQA  IVLICCCCT+LTAISMSAIATNGVVPAGGSYFMISR+LGPEFGGAVGLCFYLG
Sbjct: 149  GVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLG 208

Query: 267  TTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFI 326
            TTFAAAMYILGAIEI L YI P AAIF+   A   S A LNNMRVYGT FL  M LVVF+
Sbjct: 209  TTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFV 268

Query: 327  GVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKE 386
            GV+YVNKFASLFLACVI+SIL+IYAG IKS F PP FPVCMLGNRTLS    D+C+KT  
Sbjct: 269  GVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAV 328

Query: 387  INNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKG 446
            ++N TV ++LW FFC+S      +CD YF+ NNVT I GIPG A+G++ ENLWS YL KG
Sbjct: 329  VDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKG 388

Query: 447  EIIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDA 503
            +I+EK   PSA +  +  SL   YV+ DI TSFT+LVGIFFPSVTGIMAGSNRSGDL+DA
Sbjct: 389  DIVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDA 447

Query: 504  QKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVI 563
            QKSIP+GTILAI+TTS VY S+VVLFGACIEGVVLRDK+GD V  NLVVGTL+WPSPWVI
Sbjct: 448  QKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVI 507

Query: 564  VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAEL 623
            VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K NGEPTWALLLTA IAEL
Sbjct: 508  VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAEL 567

Query: 624  GILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICL 683
            GILIASLD+VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF+YYHWALSF+GMS+CL
Sbjct: 568  GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 627

Query: 684  ALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHT 743
            ALMF+SSWYYA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHT
Sbjct: 628  ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 687

Query: 744  KNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQ 803
            KNWRPQLLVLLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGSVI G+FLE+YGEA AAEQ
Sbjct: 688  KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 747

Query: 804  TIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARA 863
            TIK++ME EKVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN+VV+GWP GWRQSED RA
Sbjct: 748  TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 807

Query: 864  WKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQ 923
            WKTFI TVR TTAAHLALLV KNI+F+PSN E++ EG+IDVWWIVHDGGMLMLLPFLL+Q
Sbjct: 808  WKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQ 867

Query: 924  HKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTL 983
            HKVWRKC +RIFTVAQ++DNSIQMKKDLA FLYHLR+EAEVEVVEMH+SDISAYTYERTL
Sbjct: 868  HKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTL 927

Query: 984  MMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKD 1043
            MMEQRSQMLR MRL+KTER+REAQLVKDR+S LRL S+ SDE++E+    +K+ MTWT+D
Sbjct: 928  MMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRD 987

Query: 1044 KYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP 1103
            KYM      + + + F++L++++PDQSNVRRMHTAVKLNEVIV +SH+A+LVLLNMPGPP
Sbjct: 988  KYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPP 1047

Query: 1104 RNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1141
            RN EGDENYMEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1048 RNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1085


>gi|225579065 solute carrier family 12, member 4 isoform d [Homo
            sapiens]
          Length = 1079

 Score = 1665 bits (4312), Expect = 0.0
 Identities = 821/1049 (78%), Positives = 925/1049 (88%), Gaps = 4/1049 (0%)

Query: 96   LDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAK 155
            L  G+ +  + +L+      G +Y+D+NLALFEEE+D RPKVSSLL ++ +YTNLTQGAK
Sbjct: 32   LGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAK 91

Query: 156  EHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIV 215
            EHEEAE+    +++  + P MGT MGVYLPCLQNIFGVILFLRLTW+VGTAGVLQA  IV
Sbjct: 92   EHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIV 151

Query: 216  LICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYI 275
            LICCCCT+LTAISMSAIATNGVVPAGGSYFMISR+LGPEFGGAVGLCFYLGTTFAAAMYI
Sbjct: 152  LICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYI 211

Query: 276  LGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFA 335
            LGAIEI L YI P AAIF+   A   S A LNNMRVYGT FL  M LVVF+GV+YVNKFA
Sbjct: 212  LGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFA 271

Query: 336  SLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSK 395
            SLFLACVI+SIL+IYAG IKS F PP FPVCMLGNRTLS    D+C+KT  ++N TV ++
Sbjct: 272  SLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQ 331

Query: 396  LWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---P 452
            LW FFC+S      +CD YF+ NNVT I GIPG A+G++ ENLWS YL KG+I+EK   P
Sbjct: 332  LWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLP 391

Query: 453  SAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTI 512
            SA +  +  SL   YV+ DI TSFT+LVGIFFPSVTGIMAGSNRSGDL+DAQKSIP+GTI
Sbjct: 392  SADAPSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTI 450

Query: 513  LAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTC 572
            LAI+TTS VY S+VVLFGACIEGVVLRDK+GD V  NLVVGTL+WPSPWVIVIGSFFSTC
Sbjct: 451  LAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTC 510

Query: 573  GAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDL 632
            GAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K NGEPTWALLLTA IAELGILIASLD+
Sbjct: 511  GAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDM 570

Query: 633  VAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWY 692
            VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF+YYHWALSF+GMS+CLALMF+SSWY
Sbjct: 571  VAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWY 630

Query: 693  YAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLV 752
            YA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLV
Sbjct: 631  YALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLV 690

Query: 753  LLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAE 812
            LLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGSVI G+FLE+YGEA AAEQTIK++ME E
Sbjct: 691  LLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIE 750

Query: 813  KVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVR 872
            KVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN+VV+GWP GWRQSED RAWKTFI TVR
Sbjct: 751  KVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVR 810

Query: 873  VTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSI 932
             TTAAHLALLV KNI+F+PSN E++ EG+IDVWWIVHDGGMLMLLPFLL+QHKVWRKC +
Sbjct: 811  CTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRM 870

Query: 933  RIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQML 992
            RIFTVAQ++DNSIQMKKDLA FLYHLR+EAEVEVVEMH+SDISAYTYERTLMMEQRSQML
Sbjct: 871  RIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQML 930

Query: 993  RHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQK 1052
            R MRL+KTER+REAQLVKDR+S LRL S+ SDE++E+    +K+ MTWT+DKYM      
Sbjct: 931  RQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDP 990

Query: 1053 AKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENY 1112
            + + + F++L++++PDQSNVRRMHTAVKLNEVIV +SH+A+LVLLNMPGPPRN EGDENY
Sbjct: 991  SHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENY 1050

Query: 1113 MEFLEVLTEGLERVLLVRGGGSEVITIYS 1141
            MEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1051 MEFLEVLTEGLERVLLVRGGGREVITIYS 1079


>gi|225579067 solute carrier family 12, member 4 isoform e [Homo
            sapiens]
          Length = 1054

 Score = 1664 bits (4310), Expect = 0.0
 Identities = 820/1046 (78%), Positives = 924/1046 (88%), Gaps = 4/1046 (0%)

Query: 99   GHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHE 158
            G+ +  + +L+      G +Y+D+NLALFEEE+D RPKVSSLL ++ +YTNLTQGAKEHE
Sbjct: 10   GNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHE 69

Query: 159  EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 218
            EAE+    +++  + P MGT MGVYLPCLQNIFGVILFLRLTW+VGTAGVLQA  IVLIC
Sbjct: 70   EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 129

Query: 219  CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 278
            CCCT+LTAISMSAIATNGVVPAGGSYFMISR+LGPEFGGAVGLCFYLGTTFAAAMYILGA
Sbjct: 130  CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 189

Query: 279  IEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLF 338
            IEI L YI P AAIF+   A   S A LNNMRVYGT FL  M LVVF+GV+YVNKFASLF
Sbjct: 190  IEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLF 249

Query: 339  LACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWG 398
            LACVI+SIL+IYAG IKS F PP FPVCMLGNRTLS    D+C+KT  ++N TV ++LW 
Sbjct: 250  LACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWS 309

Query: 399  FFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---PSAK 455
            FFC+S      +CD YF+ NNVT I GIPG A+G++ ENLWS YL KG+I+EK   PSA 
Sbjct: 310  FFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSAD 369

Query: 456  SSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAI 515
            +  +  SL   YV+ DI TSFT+LVGIFFPSVTGIMAGSNRSGDL+DAQKSIP+GTILAI
Sbjct: 370  APSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAI 428

Query: 516  LTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAG 575
            +TTS VY S+VVLFGACIEGVVLRDK+GD V  NLVVGTL+WPSPWVIVIGSFFSTCGAG
Sbjct: 429  ITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAG 488

Query: 576  LQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAP 635
            LQSLTGAPRLLQAIAKDNIIPFLRVFGH K NGEPTWALLLTA IAELGILIASLD+VAP
Sbjct: 489  LQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAP 548

Query: 636  ILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAI 695
            ILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF+YYHWALSF+GMS+CLALMF+SSWYYA+
Sbjct: 549  ILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYAL 608

Query: 696  VAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLK 755
            VAM+IAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLVLLK
Sbjct: 609  VAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLK 668

Query: 756  LDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVK 815
            LDEDLHVK+PRLLTFASQLKAGKGLTIVGSVI G+FLE+YGEA AAEQTIK++ME EKVK
Sbjct: 669  LDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVK 728

Query: 816  GFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTT 875
            GFCQ+VVA+K+REG++HLIQSCGLGGM+HN+VV+GWP GWRQSED RAWKTFI TVR TT
Sbjct: 729  GFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTT 788

Query: 876  AAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 935
            AAHLALLV KNI+F+PSN E++ EG+IDVWWIVHDGGMLMLLPFLL+QHKVWRKC +RIF
Sbjct: 789  AAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 848

Query: 936  TVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHM 995
            TVAQ++DNSIQMKKDLA FLYHLR+EAEVEVVEMH+SDISAYTYERTLMMEQRSQMLR M
Sbjct: 849  TVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQM 908

Query: 996  RLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKS 1055
            RL+KTER+REAQLVKDR+S LRL S+ SDE++E+    +K+ MTWT+DKYM      + +
Sbjct: 909  RLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHA 968

Query: 1056 MEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEF 1115
             + F++L++++PDQSNVRRMHTAVKLNEVIV +SH+A+LVLLNMPGPPRN EGDENYMEF
Sbjct: 969  PDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEF 1028

Query: 1116 LEVLTEGLERVLLVRGGGSEVITIYS 1141
            LEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1029 LEVLTEGLERVLLVRGGGREVITIYS 1054


>gi|225579061 solute carrier family 12, member 4 isoform b [Homo
            sapiens]
          Length = 1079

 Score = 1652 bits (4277), Expect = 0.0
 Identities = 821/1058 (77%), Positives = 925/1058 (87%), Gaps = 13/1058 (1%)

Query: 90   GEHSQLLD-DGHKKARNA--YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMAN 146
            GE ++L D DGH   R +  +L+      G +Y+D+NLALFEEE+D RPKVSSLL ++ +
Sbjct: 29   GERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVS 88

Query: 147  YTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTA 206
            YTNLTQGAKEHEEAE+    +++  + P MGT MGVYLPCLQNIFGVILFLRLTW+VGTA
Sbjct: 89   YTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTA 148

Query: 207  GVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLG 266
            GVLQA  IVLICCCCT+LTAISMSAIATNGVVPAGGSYFMISR+LGPEFGGAVGLCFYLG
Sbjct: 149  GVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLG 208

Query: 267  TTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFI 326
            TTFAAAMYILGAIEI L YI P AAIF+   A   S A LNNMRVYGT FL  M LVVF+
Sbjct: 209  TTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFV 268

Query: 327  GVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKE 386
            GV+YVNKFASLFLACVI+SIL+IYAG IKS F PP FPVCMLGNRTLS    D+C+KT  
Sbjct: 269  GVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAV 328

Query: 387  INNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKG 446
            ++N TV ++LW FFC+S      +CD YF+ NNVT I GIPG A+G++ ENLWS YL KG
Sbjct: 329  VDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKG 388

Query: 447  EIIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDA 503
            +I+EK   PSA +  +  SL   YV+ DI TSFT+LVGIFFPSVTGIMAGSNRSGDL+DA
Sbjct: 389  DIVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDA 447

Query: 504  QKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVI 563
            QKSIP+GTILAI+TTS VY S+VVLFGACIEGVVLRDK+GD V  NLVVGTL+WPSPWVI
Sbjct: 448  QKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVI 507

Query: 564  VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAEL 623
            VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K NGEPTWALLLTA IAEL
Sbjct: 508  VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAEL 567

Query: 624  GILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICL 683
            GILIASLD+VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF+YYHWALSF+GMS+CL
Sbjct: 568  GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 627

Query: 684  ALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHT 743
            ALMF+SSWYYA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHT
Sbjct: 628  ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 687

Query: 744  KNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQ 803
            KNWRPQLLVLLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGSVI G+FLE+YGEA AAEQ
Sbjct: 688  KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 747

Query: 804  TIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARA 863
            TIK++ME EKVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN+VV+GWP GWRQSED RA
Sbjct: 748  TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 807

Query: 864  WKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQ 923
            WKTFI TVR TTAAHLALLV KNI+F+PSN E++ EG+IDVWWIVHDGGMLMLLPFLL+Q
Sbjct: 808  WKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQ 867

Query: 924  HKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTL 983
            HKVWRKC +RIFTVAQ++DNSIQMKKDLA FLYHLR+EAE      H+SDISAYTYERTL
Sbjct: 868  HKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE------HNSDISAYTYERTL 921

Query: 984  MMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKD 1043
            MMEQRSQMLR MRL+KTER+REAQLVKDR+S LRL S+ SDE++E+    +K+ MTWT+D
Sbjct: 922  MMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRD 981

Query: 1044 KYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP 1103
            KYM      + + + F++L++++PDQSNVRRMHTAVKLNEVIV +SH+A+LVLLNMPGPP
Sbjct: 982  KYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPP 1041

Query: 1104 RNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1141
            RN EGDENYMEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1042 RNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079


>gi|225579063 solute carrier family 12, member 4 isoform c [Homo
            sapiens]
          Length = 1087

 Score = 1641 bits (4250), Expect = 0.0
 Identities = 809/1016 (79%), Positives = 905/1016 (89%), Gaps = 4/1016 (0%)

Query: 129  EEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQ 188
            EE+D RPKVSSLL ++ +YTNLTQGAKEHEEAE+    +++  + P MGT MGVYLPCLQ
Sbjct: 73   EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132

Query: 189  NIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMIS 248
            NIFGVILFLRLTW+VGTAGVLQA  IVLICCCCT+LTAISMSAIATNGVVPAGGSYFMIS
Sbjct: 133  NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192

Query: 249  RALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNN 308
            R+LGPEFGGAVGLCFYLGTTFAAAMYILGAIEI L YI P AAIF+   A   S A LNN
Sbjct: 193  RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252

Query: 309  MRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCML 368
            MRVYGT FL  M LVVF+GV+YVNKFASLFLACVI+SIL+IYAG IKS F PP FPVCML
Sbjct: 253  MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312

Query: 369  GNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPG 428
            GNRTLS    D+C+KT  ++N TV ++LW FFC+S      +CD YF+ NNVT I GIPG
Sbjct: 313  GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372

Query: 429  LASGIITENLWSNYLPKGEIIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFP 485
             A+G++ ENLWS YL KG+I+EK   PSA +  +  SL   YV+ DI TSFT+LVGIFFP
Sbjct: 373  AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFP 431

Query: 486  SVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDA 545
            SVTGIMAGSNRSGDL+DAQKSIP+GTILAI+TTS VY S+VVLFGACIEGVVLRDK+GD 
Sbjct: 432  SVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDG 491

Query: 546  VKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSK 605
            V  NLVVGTL+WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K
Sbjct: 492  VSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK 551

Query: 606  ANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRP 665
             NGEPTWALLLTA IAELGILIASLD+VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRP
Sbjct: 552  VNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRP 611

Query: 666  RFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLS 725
            RF+YYHWALSF+GMS+CLALMF+SSWYYA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLS
Sbjct: 612  RFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLS 671

Query: 726  LSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGS 785
            LSAAR+ALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGS
Sbjct: 672  LSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGS 731

Query: 786  VIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHN 845
            VI G+FLE+YGEA AAEQTIK++ME EKVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN
Sbjct: 732  VIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHN 791

Query: 846  TVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVW 905
            +VV+GWP GWRQSED RAWKTFI TVR TTAAHLALLV KNI+F+PSN E++ EG+IDVW
Sbjct: 792  SVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVW 851

Query: 906  WIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVE 965
            WIVHDGGMLMLLPFLL+QHKVWRKC +RIFTVAQ++DNSIQMKKDLA FLYHLR+EAEVE
Sbjct: 852  WIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVE 911

Query: 966  VVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDE 1025
            VVEMH+SDISAYTYERTLMMEQRSQMLR MRL+KTER+REAQLVKDR+S LRL S+ SDE
Sbjct: 912  VVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDE 971

Query: 1026 DEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVI 1085
            ++E+    +K+ MTWT+DKYM      + + + F++L++++PDQSNVRRMHTAVKLNEVI
Sbjct: 972  EDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVI 1031

Query: 1086 VNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1141
            V +SH+A+LVLLNMPGPPRN EGDENYMEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1032 VTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087


>gi|198041678 solute carrier family 12 (potassium-chloride
            transporter), member 5 isoform 1 [Homo sapiens]
          Length = 1139

 Score = 1555 bits (4025), Expect = 0.0
 Identities = 775/1099 (70%), Positives = 897/1099 (81%), Gaps = 56/1099 (5%)

Query: 98   DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 157
            DG+ K  + ++N+++ E+G EY  KN+ALFEEEMDT P VSSLL+ +ANYTNL QG++EH
Sbjct: 42   DGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREH 101

Query: 158  EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 217
            EEAEN   GKKKP + P+MGTFMGVYLPCLQNIFGVILFLRLTWVVG AG++++F +V I
Sbjct: 102  EEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFI 161

Query: 218  CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 277
            CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 162  CCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 221

Query: 278  AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 337
             IEI L Y+ P  AIF ++DA  E+AAMLNNMRVYGT  L  M  VVF+GV+YVNKFA +
Sbjct: 222  TIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALV 281

Query: 338  FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 397
            FL CVI+SILAIYAG IKS+F PP+FP+C+LGNRTLS    DVC+K     N TV ++LW
Sbjct: 282  FLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLW 341

Query: 398  GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSS 457
            G FC SS+F NATCDEYF  NNVT IQGIPG ASG+I ENLWS+YL KG I+E+    S 
Sbjct: 342  GLFC-SSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 400

Query: 458  DVLGS----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTIL 513
             +       ++H YV  D+T+ FTLLVGI+FPSVTGIMAGSNRSGDL+DAQKSIP GTIL
Sbjct: 401  GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 460

Query: 514  AILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCG 573
            AI TTS VY+S+VVLFGACIEGVVLRDKFG+AV GNLVVGTL+WPSPWVIVIGSFFSTCG
Sbjct: 461  AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 520

Query: 574  AGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLV 633
            AGLQSLTGAPRLLQAI++D I+PFL+VFGH KANGEPTWALLLTA I E+GILIASLD V
Sbjct: 521  AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 580

Query: 634  APILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYY 693
            APILSMFFLMCY+FVNLACA+QTLLRTPNWRPRFRYYHW LSF+GMS+CLALMFI SWYY
Sbjct: 581  APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 640

Query: 694  AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVL 753
            A+VAM+IAG+IYKYIEY+GAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLVL
Sbjct: 641  ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 700

Query: 754  LKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEK 813
            +++D+D +V HP+LL+  SQLKAGKGLTIVGSV+ G FLEN+ +A  AE++I+ LMEAEK
Sbjct: 701  VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 760

Query: 814  VKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRV 873
            VKGFCQ+V+++ LR+G+SHLIQS GLGG++HNTV++GWP  WRQ ED + W+ FI  VR 
Sbjct: 761  VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 820

Query: 874  TTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIR 933
            TTA HLALLV KN+S FP N E+FSEG+IDVWWIVHDGGMLMLLPFLL+ HKVWRKC +R
Sbjct: 821  TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 880

Query: 934  IFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLR 993
            IFTVAQ++DNSIQMKKDL TFLYHLRI AEVEVVEMH+SDISAYTYE+TL+MEQRSQ+L+
Sbjct: 881  IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 940

Query: 994  HMRLSKTERDREAQLVKDR-----------NSMLRLT----------------------- 1019
             M L+K ER+RE Q + D            N+ LRL                        
Sbjct: 941  QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 1000

Query: 1020 ----------SIGSDEDEETETYQEKVHMTWTKDKYMA--SRGQKAKSMEGFQDLLNMRP 1067
                      S G + + E ET  EKVH+TWTKDK +A  ++G    S EG +D  +M+P
Sbjct: 1001 SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1060

Query: 1068 D-----QSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEG 1122
            +     QSNVRRMHTAV+LNEVIV KS +AKLVLLNMPGPPRN  GDENYMEFLEVLTE 
Sbjct: 1061 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1120

Query: 1123 LERVLLVRGGGSEVITIYS 1141
            L+RV+LVRGGG EVITIYS
Sbjct: 1121 LDRVMLVRGGGREVITIYS 1139


>gi|11968148 solute carrier family 12 (potassium-chloride
            transporter), member 5 isoform 2 [Homo sapiens]
          Length = 1116

 Score = 1555 bits (4025), Expect = 0.0
 Identities = 775/1099 (70%), Positives = 897/1099 (81%), Gaps = 56/1099 (5%)

Query: 98   DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 157
            DG+ K  + ++N+++ E+G EY  KN+ALFEEEMDT P VSSLL+ +ANYTNL QG++EH
Sbjct: 19   DGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREH 78

Query: 158  EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 217
            EEAEN   GKKKP + P+MGTFMGVYLPCLQNIFGVILFLRLTWVVG AG++++F +V I
Sbjct: 79   EEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFI 138

Query: 218  CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 277
            CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 139  CCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 198

Query: 278  AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 337
             IEI L Y+ P  AIF ++DA  E+AAMLNNMRVYGT  L  M  VVF+GV+YVNKFA +
Sbjct: 199  TIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALV 258

Query: 338  FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 397
            FL CVI+SILAIYAG IKS+F PP+FP+C+LGNRTLS    DVC+K     N TV ++LW
Sbjct: 259  FLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLW 318

Query: 398  GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSS 457
            G FC SS+F NATCDEYF  NNVT IQGIPG ASG+I ENLWS+YL KG I+E+    S 
Sbjct: 319  GLFC-SSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 377

Query: 458  DVLGS----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTIL 513
             +       ++H YV  D+T+ FTLLVGI+FPSVTGIMAGSNRSGDL+DAQKSIP GTIL
Sbjct: 378  GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 437

Query: 514  AILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCG 573
            AI TTS VY+S+VVLFGACIEGVVLRDKFG+AV GNLVVGTL+WPSPWVIVIGSFFSTCG
Sbjct: 438  AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 497

Query: 574  AGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLV 633
            AGLQSLTGAPRLLQAI++D I+PFL+VFGH KANGEPTWALLLTA I E+GILIASLD V
Sbjct: 498  AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 557

Query: 634  APILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYY 693
            APILSMFFLMCY+FVNLACA+QTLLRTPNWRPRFRYYHW LSF+GMS+CLALMFI SWYY
Sbjct: 558  APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 617

Query: 694  AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVL 753
            A+VAM+IAG+IYKYIEY+GAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLVL
Sbjct: 618  ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 677

Query: 754  LKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEK 813
            +++D+D +V HP+LL+  SQLKAGKGLTIVGSV+ G FLEN+ +A  AE++I+ LMEAEK
Sbjct: 678  VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 737

Query: 814  VKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRV 873
            VKGFCQ+V+++ LR+G+SHLIQS GLGG++HNTV++GWP  WRQ ED + W+ FI  VR 
Sbjct: 738  VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 797

Query: 874  TTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIR 933
            TTA HLALLV KN+S FP N E+FSEG+IDVWWIVHDGGMLMLLPFLL+ HKVWRKC +R
Sbjct: 798  TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 857

Query: 934  IFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLR 993
            IFTVAQ++DNSIQMKKDL TFLYHLRI AEVEVVEMH+SDISAYTYE+TL+MEQRSQ+L+
Sbjct: 858  IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 917

Query: 994  HMRLSKTERDREAQLVKDR-----------NSMLRLT----------------------- 1019
             M L+K ER+RE Q + D            N+ LRL                        
Sbjct: 918  QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 977

Query: 1020 ----------SIGSDEDEETETYQEKVHMTWTKDKYMA--SRGQKAKSMEGFQDLLNMRP 1067
                      S G + + E ET  EKVH+TWTKDK +A  ++G    S EG +D  +M+P
Sbjct: 978  SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1037

Query: 1068 D-----QSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEG 1122
            +     QSNVRRMHTAV+LNEVIV KS +AKLVLLNMPGPPRN  GDENYMEFLEVLTE 
Sbjct: 1038 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1097

Query: 1123 LERVLLVRGGGSEVITIYS 1141
            L+RV+LVRGGG EVITIYS
Sbjct: 1098 LDRVMLVRGGGREVITIYS 1116


>gi|123701900 solute carrier family 12 (potassium/chloride
            transporters), member 7 [Homo sapiens]
          Length = 1083

 Score = 1512 bits (3915), Expect = 0.0
 Identities = 749/1048 (71%), Positives = 869/1048 (82%), Gaps = 11/1048 (1%)

Query: 98   DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 157
            DG+ +  + +LNN   E+   +  KN+ALFEEEMD+ P VSSLLN++ANYTNL+QG  EH
Sbjct: 43   DGNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEH 102

Query: 158  EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 217
            EE E   E +++  K P+MGTF+GVYLPCLQNI GVILFLRLTW+VG AGVL++F IV +
Sbjct: 103  EEDE---ESRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAM 159

Query: 218  CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 277
            CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 160  CCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 219

Query: 278  AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 337
             IEIFL YI P AAIF ++ A  E+AAML+NMRVYGT  LVLM LVVF+GV+YVNK A +
Sbjct: 220  TIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALV 279

Query: 338  FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 397
            FLACV++SILAIYAG IKS+F PP  PVC+LGNRTLS R  D C K   I+N +  S LW
Sbjct: 280  FLACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALW 339

Query: 398  GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---PSA 454
            G FCN SQ  +A CDEYF+ NNVT IQGIPG ASG+  ENLWS Y   G  +EK   PS 
Sbjct: 340  GLFCNGSQP-SAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSV 398

Query: 455  KSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILA 514
              ++   +    YVL DI  SFTLLVGI+FPSVTGIMAGSNRSGDLKDAQKSIP GTILA
Sbjct: 399  PVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILA 458

Query: 515  ILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGA 574
            I+TTSF+YLS +VLFGACIEGVVLRDKFG+A++GNLV+G L+WPSPWVIVIGSFFSTCGA
Sbjct: 459  IVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGA 518

Query: 575  GLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVA 634
            GLQSLTGAPRLLQAIA+D I+PFL+VFGH KANGEPTWALLLT  I E GILIASLD VA
Sbjct: 519  GLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVA 578

Query: 635  PILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYA 694
            PILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF++YHW LSF+GMS+CLALMFI SWYYA
Sbjct: 579  PILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYA 638

Query: 695  IVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLL 754
            + AM+IAG IYKYIEY+GAEKEWGDGIRGLSL+AAR+ALLR+E GPPHTKNWRPQ+LV+L
Sbjct: 639  LSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVML 698

Query: 755  KLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKV 814
             LD +  VKHPRLL+F SQLKAGKGLTIVGSV+ G +L+ + EA  AE+ I+ LM  EK 
Sbjct: 699  NLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKT 758

Query: 815  KGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVT 874
            KGFCQLVV++ LR+G+SHLIQS GLGG+KHNTV+M WP  W+Q ++  +WK F+ TVR T
Sbjct: 759  KGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDT 818

Query: 875  TAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRI 934
            TAAH ALLVAKN+  FP N E+F  G+IDVWWIVHDGGMLMLLPFLL+QHKVWRKC +RI
Sbjct: 819  TAAHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRI 878

Query: 935  FTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH 994
            FTVAQ++DNSIQMKKDL  FLYHLRI AEVEVVEM ++DISA+TYERTLMMEQRSQML+ 
Sbjct: 879  FTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQ 938

Query: 995  MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR-GQKA 1053
            M+LSK E++REAQL+ DRN+     +    +   T    +KV MTWT++K +A +   + 
Sbjct: 939  MQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPT---PDKVQMTWTREKLIAEKYRSRD 995

Query: 1054 KSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYM 1113
             S+ GF+DL +M+PDQSNVRRMHTAVKLN V++NKS +A+LVLLNMPGPP+N +GDENYM
Sbjct: 996  TSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYM 1055

Query: 1114 EFLEVLTEGLERVLLVRGGGSEVITIYS 1141
            EFLEVLTEGL RVLLVRGGG EVITIYS
Sbjct: 1056 EFLEVLTEGLNRVLLVRGGGREVITIYS 1083


>gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo
            sapiens]
          Length = 1021

 Score =  239 bits (610), Expect = 1e-62
 Identities = 199/743 (26%), Positives = 328/743 (44%), Gaps = 139/743 (18%)

Query: 475  SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 534
            +F  +  IFFPS TGI+AG+N SGDLKD   +IP GT++AI  T+  YL+     G+C  
Sbjct: 339  TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 396

Query: 535  GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 561
              V+RD  G  +   +  G                                 T+S  S +
Sbjct: 397  --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 453

Query: 562  --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 618
              +I  G F +T  + L  L  A ++ Q + +D + P +  FG     N EP    LL  
Sbjct: 454  APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 513

Query: 619  AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 678
            AIA   I+IA L+ +API+S FFL  Y  +N +C   ++  +P WRP F+YY+   +  G
Sbjct: 514  AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 573

Query: 679  MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 738
              I + +MF+ +W+ A++A+ +   +  Y+ Y+  E  WG  ++  S + A    + L E
Sbjct: 574  AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 633

Query: 739  GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 798
               H KN+RPQ LVL           P L+ F         L I G V++G   +   E 
Sbjct: 634  VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 689

Query: 799  LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 858
                      +   K+K F   V+A  LR G+  L+Q+ GLG MK N +V+G+   W+ +
Sbjct: 690  QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 749

Query: 859  EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 891
              A   + +IG              +R+    +++ ++  +I+  F P            
Sbjct: 750  HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARVD 808

Query: 892  ----------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQ 939
                      + + Q  +G   ID++W+  DGG+ +L+P+LL + + W KC IR+F   Q
Sbjct: 809  PKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQ 868

Query: 940  LEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLS 998
            + +   Q +K + + L   R+   EV ++   + +  A   E T   E    M+   RL+
Sbjct: 869  I-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE---DMIAPFRLN 921

Query: 999  KTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEG 1058
               +D        R+   +++      DEE            TK++  + R         
Sbjct: 922  DGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR--------- 955

Query: 1059 FQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEV 1118
                                V+LNE++++ S +A L+++ +P   +       YM +LE 
Sbjct: 956  -------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLET 996

Query: 1119 LTEGLE-RVLLVRGGGSEVITIY 1140
            L++ L   V+L+RG    V+T Y
Sbjct: 997  LSQDLRPPVILIRGNQENVLTFY 1019



 Score =  123 bits (308), Expect = 1e-27
 Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)

Query: 159 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 218
           E E  T  +K P +  + G   GV + C+ NI+GVIL+LRL W+   AG++  + I+L+ 
Sbjct: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178

Query: 219 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 278
              T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F        AM+ +G 
Sbjct: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238

Query: 279 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 334
            E                D L+E  A     +N++R+ G   + +++ +   G+ + +K 
Sbjct: 239 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 285

Query: 335 ASLFLACVIVSILAIYAGAIKSSFAPP 361
             LF   ++VS    +A  +  +  PP
Sbjct: 286 QVLFFLVIMVS----FANYLVGTLIPP 308


>gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo
            sapiens]
          Length = 1029

 Score =  236 bits (601), Expect = 1e-61
 Identities = 199/752 (26%), Positives = 328/752 (43%), Gaps = 148/752 (19%)

Query: 475  SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 534
            +F  +  IFFPS TGI+AG+N SGDLKD   +IP GT++AI  T+  YL+     G+C  
Sbjct: 338  TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 395

Query: 535  GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 561
              V+RD  G  +   +  G                                 T+S  S +
Sbjct: 396  --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 452

Query: 562  --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 618
              +I  G F +T  + L  L  A ++ Q + +D + P +  FG     N EP    LL  
Sbjct: 453  APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 512

Query: 619  AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 678
            AIA   I+IA L+ +API+S FFL  Y  +N +C   ++  +P WRP F+YY+   +  G
Sbjct: 513  AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 572

Query: 679  MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 738
              I + +MF+ +W+ A++A+ +   +  Y+ Y+  E  WG  ++  S + A    + L E
Sbjct: 573  AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 632

Query: 739  GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 798
               H KN+RPQ LVL           P L+ F         L I G V++G   +   E 
Sbjct: 633  VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 688

Query: 799  LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 858
                      +   K+K F   V+A  LR G+  L+Q+ GLG MK N +V+G+   W+ +
Sbjct: 689  QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 748

Query: 859  EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 891
              A   + +IG              +R+    +++ ++  +I+  F P            
Sbjct: 749  HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGA 807

Query: 892  -------------------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKC 930
                               + + Q  +G   ID++W+  DGG+ +L+P+LL + + W KC
Sbjct: 808  RPSVSGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKC 867

Query: 931  SIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRS 989
             IR+F   Q+ +   Q +K + + L   R+   EV ++   + +  A   E T   E   
Sbjct: 868  KIRVFVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE--- 920

Query: 990  QMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR 1049
             M+   RL+   +D        R+   +++      DEE            TK++  + R
Sbjct: 921  DMIAPFRLNDGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR 963

Query: 1050 GQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGD 1109
                                         V+LNE++++ S +A L+++ +P   +     
Sbjct: 964  ----------------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPS 995

Query: 1110 ENYMEFLEVLTEGLE-RVLLVRGGGSEVITIY 1140
              YM +LE L++ L   V+L+RG    V+T Y
Sbjct: 996  SLYMAWLETLSQDLRPPVILIRGNQENVLTFY 1027



 Score =  123 bits (308), Expect = 1e-27
 Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)

Query: 159 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 218
           E E  T  +K P +  + G   GV + C+ NI+GVIL+LRL W+   AG++  + I+L+ 
Sbjct: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177

Query: 219 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 278
              T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F        AM+ +G 
Sbjct: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237

Query: 279 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 334
            E                D L+E  A     +N++R+ G   + +++ +   G+ + +K 
Sbjct: 238 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 284

Query: 335 ASLFLACVIVSILAIYAGAIKSSFAPP 361
             LF   ++VS    +A  +  +  PP
Sbjct: 285 QVLFFLVIMVS----FANYLVGTLIPP 307


>gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo
            sapiens]
          Length = 1030

 Score =  236 bits (601), Expect = 1e-61
 Identities = 199/752 (26%), Positives = 328/752 (43%), Gaps = 148/752 (19%)

Query: 475  SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 534
            +F  +  IFFPS TGI+AG+N SGDLKD   +IP GT++AI  T+  YL+     G+C  
Sbjct: 339  TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 396

Query: 535  GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 561
              V+RD  G  +   +  G                                 T+S  S +
Sbjct: 397  --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 453

Query: 562  --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 618
              +I  G F +T  + L  L  A ++ Q + +D + P +  FG     N EP    LL  
Sbjct: 454  APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 513

Query: 619  AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 678
            AIA   I+IA L+ +API+S FFL  Y  +N +C   ++  +P WRP F+YY+   +  G
Sbjct: 514  AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 573

Query: 679  MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 738
              I + +MF+ +W+ A++A+ +   +  Y+ Y+  E  WG  ++  S + A    + L E
Sbjct: 574  AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 633

Query: 739  GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 798
               H KN+RPQ LVL           P L+ F         L I G V++G   +   E 
Sbjct: 634  VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 689

Query: 799  LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 858
                      +   K+K F   V+A  LR G+  L+Q+ GLG MK N +V+G+   W+ +
Sbjct: 690  QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 749

Query: 859  EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 891
              A   + +IG              +R+    +++ ++  +I+  F P            
Sbjct: 750  HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGA 808

Query: 892  -------------------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKC 930
                               + + Q  +G   ID++W+  DGG+ +L+P+LL + + W KC
Sbjct: 809  RPSVSGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKC 868

Query: 931  SIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRS 989
             IR+F   Q+ +   Q +K + + L   R+   EV ++   + +  A   E T   E   
Sbjct: 869  KIRVFVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE--- 921

Query: 990  QMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR 1049
             M+   RL+   +D        R+   +++      DEE            TK++  + R
Sbjct: 922  DMIAPFRLNDGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR 964

Query: 1050 GQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGD 1109
                                         V+LNE++++ S +A L+++ +P   +     
Sbjct: 965  ----------------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPS 996

Query: 1110 ENYMEFLEVLTEGLE-RVLLVRGGGSEVITIY 1140
              YM +LE L++ L   V+L+RG    V+T Y
Sbjct: 997  SLYMAWLETLSQDLRPPVILIRGNQENVLTFY 1028



 Score =  123 bits (308), Expect = 1e-27
 Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)

Query: 159 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 218
           E E  T  +K P +  + G   GV + C+ NI+GVIL+LRL W+   AG++  + I+L+ 
Sbjct: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178

Query: 219 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 278
              T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F        AM+ +G 
Sbjct: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238

Query: 279 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 334
            E                D L+E  A     +N++R+ G   + +++ +   G+ + +K 
Sbjct: 239 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 285

Query: 335 ASLFLACVIVSILAIYAGAIKSSFAPP 361
             LF   ++VS    +A  +  +  PP
Sbjct: 286 QVLFFLVIMVS----FANYLVGTLIPP 308


>gi|4506975 solute carrier family 12 (sodium/potassium/chloride
           transporters), member 2 [Homo sapiens]
          Length = 1212

 Score =  223 bits (567), Expect = 1e-57
 Identities = 147/421 (34%), Positives = 215/421 (51%), Gaps = 46/421 (10%)

Query: 475 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 534
           +F  +  IFFP+ TGI+AG+N SGDL D Q +IP GT+LAIL T+ VY+   V  G+C  
Sbjct: 486 TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSC-- 543

Query: 535 GVVLRDKFGD---------------AVKGNL-------------------VVGTLSWPSP 560
             V+RD  G+               A K N                    V+  +S  +P
Sbjct: 544 --VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTP 601

Query: 561 WVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWALLLTA 618
            +I  G F +T  + L SL  AP++ QA+ KDNI P  ++F  G+ K N EP    +LT 
Sbjct: 602 -LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLRGYILTF 659

Query: 619 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 678
            IA   ILIA L+++API+S FFL  Y  +N +    +L ++P WRP F+YY+  +S +G
Sbjct: 660 LIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLG 719

Query: 679 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 738
             +C  +MF+ +W+ A++  VI   +Y Y+ Y+  +  WG   + L+   A    +RL  
Sbjct: 720 AILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSG 779

Query: 739 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 798
              H KN+RPQ LV+           P LL          GL I G V +G   +   E 
Sbjct: 780 VEDHVKNFRPQCLVMTGAPN----SRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEM 835

Query: 799 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 858
              +   +  +   K+K F   V A  LREG  +L+Q+ GLG MK NT+V+G+   W Q+
Sbjct: 836 SIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQA 895

Query: 859 E 859
           +
Sbjct: 896 D 896



 Score =  122 bits (307), Expect = 1e-27
 Identities = 91/339 (26%), Positives = 161/339 (47%), Gaps = 43/339 (12%)

Query: 27  SSRSSSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQN 86
           S  +  R R +  +    +S  + +S+ +G       V +D P+    +  D +  LS+ 
Sbjct: 132 SEEAKGRFRVNFVDPAASSSAEDSLSDAAG-------VGVDGPNVSFQNGGDTV--LSEG 182

Query: 87  SI--------TGEHSQLLDDGHKKARNAYLNNSNYEEGD-----EYFDKNLALFEEEMDT 133
           S         +G H     D H      YL    +   D     +++    A   E++  
Sbjct: 183 SSLHSGGGGGSGHHQHYYYDTH--TNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKL-L 239

Query: 134 RPKVSSLLNRMAN------YTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCL 187
           RP ++ L + +        + N  +     +     T   K   K    G   GV + C+
Sbjct: 240 RPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVK---FGWIKGVLVRCM 296

Query: 188 QNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMI 247
            NI+GV+LF+RL+W+VG AG+  +  ++++    T +T +S SAIATNG V  GG+Y++I
Sbjct: 297 LNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLI 356

Query: 248 SRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLN 307
           SR+LGPEFGGA+GL F      A AMY++G  E  +V ++   +I   D+        +N
Sbjct: 357 SRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAET-VVELLKEHSILMIDE--------IN 407

Query: 308 NMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSI 346
           ++R+ G   +V+++ +   G+ +  K   + L  ++++I
Sbjct: 408 DIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 58/245 (23%), Positives = 110/245 (44%), Gaps = 55/245 (22%)

Query: 899  EGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQM-KKDLATFLYH 957
            +  IDVWW+  DGG+ +L+P+LL   K W+ C IR+F   ++  N I   ++ +AT L  
Sbjct: 1021 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSK 1078

Query: 958  LRIE-AEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSML 1016
             RI+ +++ V+     DI+    +  ++  +  +++   RL + +++++       +   
Sbjct: 1079 FRIDFSDIMVL----GDINTKPKKENIIAFE--EIIEPYRLHEDDKEQDIADKMKEDEPW 1132

Query: 1017 RLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMH 1076
            R+T      D E E Y+ K                                        +
Sbjct: 1133 RIT------DNELELYKTKT---------------------------------------Y 1147

Query: 1077 TAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEV 1136
              ++LNE++   S  A ++++++P   +       YM +LE L++ L  +LLVRG    V
Sbjct: 1148 RQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSV 1207

Query: 1137 ITIYS 1141
            +T YS
Sbjct: 1208 LTFYS 1212


>gi|134254459 sodium potassium chloride cotransporter 2 [Homo
           sapiens]
          Length = 1099

 Score =  211 bits (538), Expect = 2e-54
 Identities = 142/421 (33%), Positives = 207/421 (49%), Gaps = 50/421 (11%)

Query: 476 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEG 535
           F  +  IFFP+ TGI+AG+N SGDL+D Q +IP GT+LAI  T+  YL   +  GAC   
Sbjct: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436

Query: 536 VVLRDKFGDA---------VKGNLVVG----------------------TLSWPSPW--V 562
            V+RD  G+            G+   G                       +S  S +  +
Sbjct: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495

Query: 563 IVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWALLLTAAI 620
           I  G F +T  + L SL  AP++ QA+ KDNI   L+ F  G+ K N EP    +LT  I
Sbjct: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554

Query: 621 AELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMS 680
           A   ILIA L+ +API+S FFL  Y  +N +C   +  ++P WRP +  Y+  +S  G  
Sbjct: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614

Query: 681 ICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGP 740
           +C A+MF+ +W+ A++  VI   +Y Y+  +  +  WG   + LS  +A    L L    
Sbjct: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674

Query: 741 PHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGN---FLENYGE 797
            H KN+RPQ +VL        +  P LL          GL I   V VG     ++    
Sbjct: 675 DHVKNFRPQCIVL----TGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730

Query: 798 ALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQ 857
            +A +Q     +   K+K F   V A   R+G+  L+Q+ GLG MK NT+V+G+   WR+
Sbjct: 731 GMAKKQA---WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRK 787

Query: 858 S 858
           +
Sbjct: 788 A 788



 Score =  132 bits (331), Expect = 2e-30
 Identities = 83/253 (32%), Positives = 135/253 (53%), Gaps = 25/253 (9%)

Query: 107 YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVS-SLLNRMANYTNLTQGAKEHEEAENITE 165
           Y  N+    G +    +L    E++     V+ S  +R+AN      G    E+AEN  +
Sbjct: 114 YYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVAN----GDGIPGDEQAENKED 169

Query: 166 GKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLT 225
            +    K    G   GV + C+ NI+GV+LF+RL+W+VG AG+     I+L+    T +T
Sbjct: 170 DQAGVVK---FGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSIT 226

Query: 226 AISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVY 285
            +S SAIATNG V  GG+Y++ISR+LGPEFGG++GL F      A AMY++G  E  +  
Sbjct: 227 GLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVV-- 284

Query: 286 IVPRAAIFHSDDALKESAAML----NNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLAC 341
                      D LKES +M+    N++R+ G+  +V+++ +   G+ +  K   + L  
Sbjct: 285 -----------DLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVI 333

Query: 342 VIVSILAIYAGAI 354
           ++++I   + G +
Sbjct: 334 LLIAIANFFIGTV 346



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 68/275 (24%), Positives = 124/275 (45%), Gaps = 55/275 (20%)

Query: 869  GTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWR 928
            G++  + + H+     K +       ++  +G IDVWW+  DGG+ +L+P++L   K W+
Sbjct: 878  GSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWK 937

Query: 929  KCSIRIFTVAQLEDNSIQMKK-DLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMME 986
             C +RI+   ++  N I+ +K  +A+ L   RI+ A++ ++     DI+    + +  + 
Sbjct: 938  DCKLRIYVGGKI--NRIEEEKIVMASLLSKFRIKFADIHII----GDINIRPNKESWKVF 991

Query: 987  QRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYM 1046
            +  +M+   RL ++ +D        R +  ++T      D E E  +EK           
Sbjct: 992  E--EMIEPYRLHESCKDLTTAEKLKRETPWKIT------DAELEAVKEK----------- 1032

Query: 1047 ASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNP 1106
                                         +  V+LNE++   S  A L++L++P   +  
Sbjct: 1033 ----------------------------SYRQVRLNELLQEHSRAANLIVLSLPVARKGS 1064

Query: 1107 EGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1141
              D  YM +LE+LT+ L  VLLVRG    V+T YS
Sbjct: 1065 ISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099


>gi|31881740 solute carrier family 12 (potassium/chloride
           transporters), member 9 [Homo sapiens]
          Length = 914

 Score =  195 bits (496), Expect = 2e-49
 Identities = 130/412 (31%), Positives = 214/412 (51%), Gaps = 37/412 (8%)

Query: 453 SAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTI 512
           S+   D LG+   E        +F  +  + F   TGIMAG+N SG+LKD  ++IP+GTI
Sbjct: 244 SSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTI 303

Query: 513 LAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTC 572
           +A+  T FVY+    L     +  +L++ +G     +L      WP   +++IG + +  
Sbjct: 304 VAVAYTFFVYVLLFFLSSFTCDRTLLQEDYGFFRAISL------WPP--LVLIGIYATAL 355

Query: 573 GAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTA-AIAELGILIASLD 631
            A + SL GA R+L A+A+D++   +       + G   WA +L +  + +L +L   L+
Sbjct: 356 SASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLN 415

Query: 632 LVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSW 691
            +A ++++F+L+ Y  V+L+C        PN+RP F  + W    +G++ CL +MF+ S 
Sbjct: 416 TLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISP 475

Query: 692 YYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLL 751
             A  ++++ G++   +  +G    WG   + L     R  LLRL+    H K WRPQLL
Sbjct: 476 GAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLL 535

Query: 752 VLLKLDEDLHVKHPR----LLTFASQLKAGKGLTIVGSVIVGNF--------LENYGEAL 799
           +L        V +PR    LL  A+QLK G GL ++G V +G+            YG  L
Sbjct: 536 LL--------VGNPRGALPLLRLANQLKKG-GLYVLGHVTLGDLDSLPSDPVQPQYGAWL 586

Query: 800 AAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGW 851
           +       L++  +VK F  L ++  +R+G  HL++  GLGGMK NT+V+G+
Sbjct: 587 S-------LVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGF 631



 Score =  112 bits (279), Expect = 3e-24
 Identities = 53/109 (48%), Positives = 77/109 (70%)

Query: 175 QMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIAT 234
           ++ TF+GV +P + ++F +++FLR+ +VVG AG+LQA A++L+      LT +S+ AIAT
Sbjct: 36  KLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIAT 95

Query: 235 NGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFL 283
           NG V  GG+YFMISR LGPE GG++GL FYL      A+ +LG +E  L
Sbjct: 96  NGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVL 144



 Score = 31.6 bits (70), Expect = 4.5
 Identities = 16/38 (42%), Positives = 19/38 (50%)

Query: 1094 LVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRG 1131
            L  L +P PP +P     Y+  LE LT  L   LLV G
Sbjct: 868  LTFLYLPRPPADPARYPRYLALLETLTRDLGPTLLVHG 905


>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
          Length = 714

 Score =  104 bits (260), Expect = 4e-22
 Identities = 59/176 (33%), Positives = 102/176 (57%), Gaps = 9/176 (5%)

Query: 475 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 534
           SF  + G+FFP+ TG+MAG N  GDL++   SIP+G++ A+  + F+Y+  V L GA   
Sbjct: 232 SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICT 291

Query: 535 GVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 594
              LR  F  A K +L+         ++ ++G + S+  + +  L GAPR+LQ IA++ +
Sbjct: 292 REALRYDFLIAEKVSLM--------GFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKV 343

Query: 595 IPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVN 649
           IP L   G  K  N  P  A+ LT+ +    + +  ++++API+++ F++ Y+ V+
Sbjct: 344 IPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVD 399



 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 62/207 (29%), Positives = 94/207 (45%), Gaps = 27/207 (13%)

Query: 157 HEEAENITEGKKKPTKTPQM--------GTFMGVYLPCLQNIFGVILFLRLTWVVGTAGV 208
           HE A+     + +P    Q+        GT+ GV+  C+ NIFGV+LFLR  W+VG  GV
Sbjct: 12  HEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGV 71

Query: 209 LQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTT 268
           L    +V       ++T +S   +     + +GG Y MIS  LG + GG +GL +  G  
Sbjct: 72  LLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQC 131

Query: 269 FAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVL--VVFI 326
            A AMYI G  E                 ++ +   + N   V G +  VL+ L  +   
Sbjct: 132 VAGAMYITGFAE-----------------SISDLLGLGNIWAVRGISVAVLLALLGINLA 174

Query: 327 GVRYVNKFASLFLACVIVSILAIYAGA 353
           GV+++ +   L L  + VS L    G+
Sbjct: 175 GVKWIIRLQLLLLFLLAVSTLDFVVGS 201



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 25/79 (31%), Positives = 36/79 (45%), Gaps = 16/79 (20%)

Query: 663 WRPRFRYYH-----WALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEW 717
           WR    +Y      W +S +G    L +MF+  W Y +V M +A ++Y YI         
Sbjct: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI--------- 631

Query: 718 GDGIRGLSL-SAARFALLR 735
           G    GL L SA+ F+  R
Sbjct: 632 GRASPGLHLGSASNFSFFR 650


>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
           sapiens]
          Length = 697

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 51/211 (24%), Positives = 83/211 (39%), Gaps = 21/211 (9%)

Query: 450 EKPSAKSSDVLGS-----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQ 504
           E PS   + + G+           L    T F   VG    + TG         ++++ Q
Sbjct: 274 EPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTG--------EEVRNPQ 325

Query: 505 KSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSW-PSPWVI 563
           K+IPIG + ++L     Y          +   +L +K    V    V     W P+ +V+
Sbjct: 326 KAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVV 381

Query: 564 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAEL 623
             GS  +   + L S+   PR+L A+A+D ++   R          P  A L    I+ L
Sbjct: 382 AAGSLCALSTSLLGSMFPLPRILFAMARDGLL--FRFLARVSKRQSPVAATLTAGVISAL 439

Query: 624 GILIASLDLVAPILSMFFLMCYLFVNLACAL 654
              +  L  +  ++S+  LM Y  V  AC L
Sbjct: 440 MAFLFDLKALVDMMSIGTLMAYSLV-AACVL 469


>gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo
           sapiens]
          Length = 658

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 51/211 (24%), Positives = 87/211 (41%), Gaps = 20/211 (9%)

Query: 450 EKPSAKSSDVLGS-----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQ 504
           E PS   + + G+           L    T F   VG    + TG         ++++ Q
Sbjct: 234 EPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTG--------EEVRNPQ 285

Query: 505 KSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSW-PSPWVI 563
           K+IPIG + ++L     Y          +   +L +K    V    V     W P+ +V+
Sbjct: 286 KAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVV 341

Query: 564 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAEL 623
             GS  +   + L S+   PR++ A+A+D ++ F  +   +     P  A L + A+A L
Sbjct: 342 AAGSLCALSTSLLGSIFPMPRVIYAMAEDGLL-FKCLAQINSKTKTPIIATLSSGAVAAL 400

Query: 624 GILIASLDLVAPILSMFFLMCYLFVNLACAL 654
              +  L  +  ++S+  LM Y  V  AC L
Sbjct: 401 MAFLFDLKALVDMMSIGTLMAYSLV-AACVL 430


>gi|4507047 solute carrier family 7 (cationic amino acid
           transporter, y+ system), member 1 [Homo sapiens]
          Length = 629

 Score = 40.4 bits (93), Expect = 0.010
 Identities = 48/208 (23%), Positives = 89/208 (42%), Gaps = 27/208 (12%)

Query: 468 VLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLS--- 524
           VL    T F   VG    + TG         ++K+ QK+IP+G + ++L     Y     
Sbjct: 255 VLSGAATCFYAFVGFDCIATTG--------EEVKNPQKAIPVGIVASLLICFIAYFGVSA 306

Query: 525 --NVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWP-SPWVIVIGSFFSTCGAGLQSLTG 581
              +++   C++         DA K       + W  + + + +GS  +   + L S+  
Sbjct: 307 ALTLMMPYFCLDN---NSPLPDAFK------HVGWEGAKYAVAVGSLCALSASLLGSMFP 357

Query: 582 APRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 641
            PR++ A+A+D ++ F  +   +     P  A L + A+A +   +  L  +  ++S+  
Sbjct: 358 MPRVIYAMAEDGLL-FKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGT 416

Query: 642 LMCYLFVNLACALQTLLRTPNWRPRFRY 669
           L+ Y  V  AC L  +LR    +P   Y
Sbjct: 417 LLAYSLV-AACVL--VLRYQPEQPNLVY 441


>gi|9790235 solute carrier family 7, member 10 [Homo sapiens]
          Length = 523

 Score = 37.4 bits (85), Expect = 0.082
 Identities = 39/168 (23%), Positives = 68/168 (40%), Gaps = 6/168 (3%)

Query: 499 DLKDAQKSIPIGTILAILTTSFVY-LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSW 557
           ++ DA+K++P    ++I   +FVY  +N+  F A     +L         G  ++G  SW
Sbjct: 257 EMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELLSSNAVAVTFGEKLLGYFSW 316

Query: 558 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLT 617
             P  + + +F    G     L    RL  + A++  +P L    H + +  P  ALL+ 
Sbjct: 317 VMPVSVALSTFGGING----YLFTYSRLCFSGAREGHLPSLLAMIHVR-HCTPIPALLVC 371

Query: 618 AAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRP 665
                + +L+     +   +S    +CY    L   L    R    RP
Sbjct: 372 CGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWRRPALHRP 419


>gi|7662238 apoptotic chromatin condensation inducer 1 [Homo
           sapiens]
          Length = 1341

 Score = 36.2 bits (82), Expect = 0.18
 Identities = 42/155 (27%), Positives = 64/155 (41%), Gaps = 12/155 (7%)

Query: 21  DTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDPPSDRTSHPQDVI 80
           D  P    R SSRVR +    + E S  +P  E     T    + +   +DR    ++  
Sbjct: 218 DEKPRKGERRSSRVRQARAAKLSEGS--QPAEEEEDQETPSRNLRVR--ADRNLKTEEEE 273

Query: 81  EDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSS- 139
           E+  +     E  +  D+G +K+R A +     EEG+E         EE MD RPK  S 
Sbjct: 274 EEEEEEEEDDEEEEGDDEG-QKSREAPILKEFKEEGEEI---PRVKPEEMMDERPKTRSQ 329

Query: 140 ---LLNRMANYTNLTQGAKEHEEAENITEGKKKPT 171
              +L R   +T   + A++   A    E + K T
Sbjct: 330 EQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTT 364


>gi|195927037 DNA (cytosine-5-)-methyltransferase 1 isoform a [Homo
            sapiens]
          Length = 1632

 Score = 36.2 bits (82), Expect = 0.18
 Identities = 29/124 (23%), Positives = 47/124 (37%), Gaps = 1/124 (0%)

Query: 981  RTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTW 1040
            RT   E+R +       S+T+     Q +K+         + +DEDE+ +   EK H + 
Sbjct: 246  RTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQ 305

Query: 1041 TKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMP 1100
             KD   A R  + K  E     ++   D+             E    K   AK V+ +  
Sbjct: 306  PKD-LAAKRRPEEKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVMNSKT 364

Query: 1101 GPPR 1104
             PP+
Sbjct: 365  HPPK 368


>gi|4503351 DNA (cytosine-5-)-methyltransferase 1 isoform b [Homo
            sapiens]
          Length = 1616

 Score = 36.2 bits (82), Expect = 0.18
 Identities = 29/124 (23%), Positives = 47/124 (37%), Gaps = 1/124 (0%)

Query: 981  RTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTW 1040
            RT   E+R +       S+T+     Q +K+         + +DEDE+ +   EK H + 
Sbjct: 230  RTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQ 289

Query: 1041 TKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMP 1100
             KD   A R  + K  E     ++   D+             E    K   AK V+ +  
Sbjct: 290  PKD-LAAKRRPEEKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVMNSKT 348

Query: 1101 GPPR 1104
             PP+
Sbjct: 349  HPPK 352


>gi|181337167 solute carrier family 7 (cationic amino acid
           transporter, y+ system), member 14 [Homo sapiens]
          Length = 771

 Score = 36.2 bits (82), Expect = 0.18
 Identities = 43/188 (22%), Positives = 79/188 (42%), Gaps = 14/188 (7%)

Query: 468 VLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVV 527
           VL    T F   +G    + TG  A        K+   SIP     +++     Y+S  V
Sbjct: 254 VLQGAATCFYAFIGFDIIATTGEEA--------KNPNTSIPYAITASLVICLTAYVSVSV 305

Query: 528 LFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQ 587
           +    +    +     ++    + V    + + +V+ IGS      + L SL   PR++ 
Sbjct: 306 ILTLMVPYYTIDT---ESPLMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIY 362

Query: 588 AIAKDNIIPFLRVFGHSKANGE-PTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYL 646
           A+A D ++   R   H  +  E P  A +++  +A L  L+ SL  +  ++S+  L+ Y 
Sbjct: 363 AMAGDGLL--FRFLAHVSSYTETPVVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYT 420

Query: 647 FVNLACAL 654
            V++   L
Sbjct: 421 LVSVCVLL 428


>gi|114326550 solute carrier family 7 (cationic amino acid
           transporter, y+ system), member 3 [Homo sapiens]
          Length = 619

 Score = 35.4 bits (80), Expect = 0.31
 Identities = 43/191 (22%), Positives = 83/191 (43%), Gaps = 17/191 (8%)

Query: 466 EYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSN 525
           E +L    T F   VG    + TG  A        ++ Q+SIP+G ++++      Y + 
Sbjct: 251 EGILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAV 302

Query: 526 VVLFGACIEGVVLRDKFGDAVKGNLVVGTLSW-PSPWVIVIGSFFSTCGAGLQSLTGAPR 584
                  +    L+ +     +  L +G   W P+ +V+ +GS  +   + L S+   PR
Sbjct: 303 SSALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPR 358

Query: 585 LLQAIAKDNIIPFLRVFGH-SKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLM 643
           ++ A+A+D ++   RV          P  A +++  IA     +  L  +  ++S+  L+
Sbjct: 359 VIYAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLL 416

Query: 644 CYLFVNLACAL 654
            Y  V++ C L
Sbjct: 417 AYSLVSI-CVL 426


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,029,992
Number of Sequences: 37866
Number of extensions: 1706743
Number of successful extensions: 5413
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 5290
Number of HSP's gapped (non-prelim): 129
length of query: 1141
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1028
effective length of database: 13,968,660
effective search space: 14359782480
effective search space used: 14359782480
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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