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Search of human proteins with 110224449
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110224449 solute carrier family 12, member 6 isoform a [Homo
sapiens]
(1150 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110224449 solute carrier family 12, member 6 isoform a [Homo ... 2291 0.0
gi|110224456 solute carrier family 12, member 6 isoform d [Homo ... 2271 0.0
gi|110224458 solute carrier family 12, member 6 isoform e [Homo ... 2252 0.0
gi|110224454 solute carrier family 12, member 6 isoform c [Homo ... 2176 0.0
gi|110224452 solute carrier family 12, member 6 isoform c [Homo ... 2176 0.0
gi|4826780 solute carrier family 12, member 6 isoform b [Homo sa... 2118 0.0
gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa... 1669 0.0
gi|225579065 solute carrier family 12, member 4 isoform d [Homo ... 1665 0.0
gi|225579067 solute carrier family 12, member 4 isoform e [Homo ... 1664 0.0
gi|225579061 solute carrier family 12, member 4 isoform b [Homo ... 1652 0.0
gi|225579063 solute carrier family 12, member 4 isoform c [Homo ... 1641 0.0
gi|198041678 solute carrier family 12 (potassium-chloride transp... 1555 0.0
gi|11968148 solute carrier family 12 (potassium-chloride transpo... 1555 0.0
gi|123701900 solute carrier family 12 (potassium/chloride transp... 1512 0.0
gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo ... 239 1e-62
gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo ... 236 1e-61
gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo ... 236 1e-61
gi|4506975 solute carrier family 12 (sodium/potassium/chloride t... 223 1e-57
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap... 211 2e-54
gi|31881740 solute carrier family 12 (potassium/chloride transpo... 195 2e-49
gi|38569457 solute carrier family 12, member 8 [Homo sapiens] 104 4e-22
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s... 47 1e-04
gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo s... 46 2e-04
gi|4507047 solute carrier family 7 (cationic amino acid transpor... 40 0.010
gi|9790235 solute carrier family 7, member 10 [Homo sapiens] 37 0.083
gi|91982772 mucin 17 [Homo sapiens] 37 0.14
gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi... 36 0.18
gi|195927037 DNA (cytosine-5-)-methyltransferase 1 isoform a [Ho... 36 0.18
gi|4503351 DNA (cytosine-5-)-methyltransferase 1 isoform b [Homo... 36 0.18
gi|181337167 solute carrier family 7 (cationic amino acid transp... 36 0.18
>gi|110224449 solute carrier family 12, member 6 isoform a [Homo
sapiens]
Length = 1150
Score = 2291 bits (5936), Expect = 0.0
Identities = 1150/1150 (100%), Positives = 1150/1150 (100%)
Query: 1 MHPPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPM 60
MHPPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPM
Sbjct: 1 MHPPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPM 60
Query: 61 SEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNS 120
SEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNS
Sbjct: 61 SEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNS 120
Query: 121 NYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPT 180
NYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPT
Sbjct: 121 NYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPT 180
Query: 181 KTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSA 240
KTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSA
Sbjct: 181 KTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSA 240
Query: 241 IATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAA 300
IATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAA
Sbjct: 241 IATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAA 300
Query: 301 IFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYA 360
IFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYA
Sbjct: 301 IFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYA 360
Query: 361 GAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATC 420
GAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATC
Sbjct: 361 GAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATC 420
Query: 421 DEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVD 480
DEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVD
Sbjct: 421 DEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVD 480
Query: 481 ITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGA 540
ITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGA
Sbjct: 481 ITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGA 540
Query: 541 CIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAK 600
CIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAK
Sbjct: 541 CIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAK 600
Query: 601 DNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLA 660
DNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLA
Sbjct: 601 DNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLA 660
Query: 661 CALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQ 720
CALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQ
Sbjct: 661 CALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQ 720
Query: 721 GAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFA 780
GAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFA
Sbjct: 721 GAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFA 780
Query: 781 SQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGIS 840
SQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGIS
Sbjct: 781 SQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGIS 840
Query: 841 HLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFP 900
HLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFP
Sbjct: 841 HLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFP 900
Query: 901 SNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDL 960
SNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDL
Sbjct: 901 SNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDL 960
Query: 961 ATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKD 1020
ATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKD
Sbjct: 961 ATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKD 1020
Query: 1021 RNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSN 1080
RNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSN
Sbjct: 1021 RNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSN 1080
Query: 1081 VRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRG 1140
VRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRG
Sbjct: 1081 VRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRG 1140
Query: 1141 GGSEVITIYS 1150
GGSEVITIYS
Sbjct: 1141 GGSEVITIYS 1150
>gi|110224456 solute carrier family 12, member 6 isoform d [Homo
sapiens]
Length = 1141
Score = 2271 bits (5884), Expect = 0.0
Identities = 1141/1141 (100%), Positives = 1141/1141 (100%)
Query: 10 MASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTS 69
MASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTS
Sbjct: 1 MASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTS 60
Query: 70 LATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYF 129
LATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYF
Sbjct: 61 LATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYF 120
Query: 130 DKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFM 189
DKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFM
Sbjct: 121 DKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFM 180
Query: 190 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 249
GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA
Sbjct: 181 GVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPA 240
Query: 250 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 309
GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK
Sbjct: 241 GGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALK 300
Query: 310 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAP 369
ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAP
Sbjct: 301 ESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAP 360
Query: 370 PHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNV 429
PHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNV
Sbjct: 361 PHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNV 420
Query: 430 TSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLV 489
TSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLV
Sbjct: 421 TSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLV 480
Query: 490 GIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRD 549
GIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRD
Sbjct: 481 GIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRD 540
Query: 550 KFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRV 609
KFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRV
Sbjct: 541 KFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRV 600
Query: 610 FGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRT 669
FGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRT
Sbjct: 601 FGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRT 660
Query: 670 PNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDG 729
PNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDG
Sbjct: 661 PNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDG 720
Query: 730 IRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGL 789
IRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGL
Sbjct: 721 IRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGL 780
Query: 790 TIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLG 849
TIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLG
Sbjct: 781 TIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLG 840
Query: 850 GMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEG 909
GMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEG
Sbjct: 841 GMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEG 900
Query: 910 NIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRI 969
NIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRI
Sbjct: 901 NIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRI 960
Query: 970 EAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTS 1029
EAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTS
Sbjct: 961 EAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTS 1020
Query: 1030 IGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVK 1089
IGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVK
Sbjct: 1021 IGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVK 1080
Query: 1090 LNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIY 1149
LNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIY
Sbjct: 1081 LNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIY 1140
Query: 1150 S 1150
S
Sbjct: 1141 S 1141
>gi|110224458 solute carrier family 12, member 6 isoform e [Homo
sapiens]
Length = 1135
Score = 2252 bits (5836), Expect = 0.0
Identities = 1135/1150 (98%), Positives = 1135/1150 (98%), Gaps = 15/1150 (1%)
Query: 1 MHPPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPM 60
MHPPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPM
Sbjct: 1 MHPPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPM 60
Query: 61 SEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNS 120
SEMSGATTSLATVALDPPSDRTSHPQDVIED DGHKKARNAYLNNS
Sbjct: 61 SEMSGATTSLATVALDPPSDRTSHPQDVIED---------------DGHKKARNAYLNNS 105
Query: 121 NYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPT 180
NYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPT
Sbjct: 106 NYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPT 165
Query: 181 KTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSA 240
KTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSA
Sbjct: 166 KTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSA 225
Query: 241 IATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAA 300
IATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAA
Sbjct: 226 IATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAA 285
Query: 301 IFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYA 360
IFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYA
Sbjct: 286 IFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYA 345
Query: 361 GAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATC 420
GAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATC
Sbjct: 346 GAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATC 405
Query: 421 DEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVD 480
DEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVD
Sbjct: 406 DEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVD 465
Query: 481 ITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGA 540
ITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGA
Sbjct: 466 ITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGA 525
Query: 541 CIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAK 600
CIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAK
Sbjct: 526 CIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAK 585
Query: 601 DNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLA 660
DNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLA
Sbjct: 586 DNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLA 645
Query: 661 CALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQ 720
CALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQ
Sbjct: 646 CALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQ 705
Query: 721 GAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFA 780
GAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFA
Sbjct: 706 GAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFA 765
Query: 781 SQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGIS 840
SQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGIS
Sbjct: 766 SQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGIS 825
Query: 841 HLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFP 900
HLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFP
Sbjct: 826 HLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFP 885
Query: 901 SNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDL 960
SNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDL
Sbjct: 886 SNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDL 945
Query: 961 ATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKD 1020
ATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKD
Sbjct: 946 ATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKD 1005
Query: 1021 RNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSN 1080
RNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSN
Sbjct: 1006 RNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSN 1065
Query: 1081 VRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRG 1140
VRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRG
Sbjct: 1066 VRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRG 1125
Query: 1141 GGSEVITIYS 1150
GGSEVITIYS
Sbjct: 1126 GGSEVITIYS 1135
>gi|110224454 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 2176 bits (5639), Expect = 0.0
Identities = 1091/1091 (100%), Positives = 1091/1091 (100%)
Query: 60 MSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNN 119
MSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNN
Sbjct: 1 MSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNN 60
Query: 120 SNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP 179
SNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP
Sbjct: 61 SNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP 120
Query: 180 TKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMS 239
TKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMS
Sbjct: 121 TKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMS 180
Query: 240 AIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRA 299
AIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRA
Sbjct: 181 AIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRA 240
Query: 300 AIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIY 359
AIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIY
Sbjct: 241 AIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIY 300
Query: 360 AGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNAT 419
AGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNAT
Sbjct: 301 AGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNAT 360
Query: 420 CDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLV 479
CDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLV
Sbjct: 361 CDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLV 420
Query: 480 DITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG 539
DITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG
Sbjct: 421 DITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG 480
Query: 540 ACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA 599
ACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA
Sbjct: 481 ACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA 540
Query: 600 KDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNL 659
KDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNL
Sbjct: 541 KDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNL 600
Query: 660 ACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEY 719
ACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEY
Sbjct: 601 ACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEY 660
Query: 720 QGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTF 779
QGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTF
Sbjct: 661 QGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTF 720
Query: 780 ASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGI 839
ASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGI
Sbjct: 721 ASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGI 780
Query: 840 SHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFF 899
SHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFF
Sbjct: 781 SHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFF 840
Query: 900 PSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKD 959
PSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKD
Sbjct: 841 PSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKD 900
Query: 960 LATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVK 1019
LATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVK
Sbjct: 901 LATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVK 960
Query: 1020 DRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQS 1079
DRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQS
Sbjct: 961 DRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQS 1020
Query: 1080 NVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVR 1139
NVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVR
Sbjct: 1021 NVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVR 1080
Query: 1140 GGGSEVITIYS 1150
GGGSEVITIYS
Sbjct: 1081 GGGSEVITIYS 1091
>gi|110224452 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 2176 bits (5639), Expect = 0.0
Identities = 1091/1091 (100%), Positives = 1091/1091 (100%)
Query: 60 MSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNN 119
MSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNN
Sbjct: 1 MSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNN 60
Query: 120 SNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP 179
SNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP
Sbjct: 61 SNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP 120
Query: 180 TKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMS 239
TKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMS
Sbjct: 121 TKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMS 180
Query: 240 AIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRA 299
AIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRA
Sbjct: 181 AIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRA 240
Query: 300 AIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIY 359
AIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIY
Sbjct: 241 AIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIY 300
Query: 360 AGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNAT 419
AGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNAT
Sbjct: 301 AGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNAT 360
Query: 420 CDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLV 479
CDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLV
Sbjct: 361 CDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLV 420
Query: 480 DITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG 539
DITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG
Sbjct: 421 DITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFG 480
Query: 540 ACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA 599
ACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA
Sbjct: 481 ACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIA 540
Query: 600 KDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNL 659
KDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNL
Sbjct: 541 KDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNL 600
Query: 660 ACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEY 719
ACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEY
Sbjct: 601 ACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEY 660
Query: 720 QGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTF 779
QGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTF
Sbjct: 661 QGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTF 720
Query: 780 ASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGI 839
ASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGI
Sbjct: 721 ASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGI 780
Query: 840 SHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFF 899
SHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFF
Sbjct: 781 SHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFF 840
Query: 900 PSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKD 959
PSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKD
Sbjct: 841 PSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKD 900
Query: 960 LATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVK 1019
LATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVK
Sbjct: 901 LATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVK 960
Query: 1020 DRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQS 1079
DRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQS
Sbjct: 961 DRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQS 1020
Query: 1080 NVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVR 1139
NVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVR
Sbjct: 1021 NVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVR 1080
Query: 1140 GGGSEVITIYS 1150
GGGSEVITIYS
Sbjct: 1081 GGGSEVITIYS 1091
>gi|4826780 solute carrier family 12, member 6 isoform b [Homo
sapiens]
Length = 1099
Score = 2118 bits (5487), Expect = 0.0
Identities = 1066/1082 (98%), Positives = 1072/1082 (99%), Gaps = 2/1082 (0%)
Query: 71 ATVALDPP-SDRTSHPQDVIE-DLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEY 128
A+++ +P +D + QD E DLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEY
Sbjct: 18 ASISQEPSLADIKARIQDSDEPDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEY 77
Query: 129 FDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTF 188
FDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTF
Sbjct: 78 FDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTF 137
Query: 189 MGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVP 248
MGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVP
Sbjct: 138 MGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVP 197
Query: 249 AGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDAL 308
AGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDAL
Sbjct: 198 AGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDAL 257
Query: 309 KESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFA 368
KESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFA
Sbjct: 258 KESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFA 317
Query: 369 PPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNN 428
PPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNN
Sbjct: 318 PPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNN 377
Query: 429 VTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLL 488
VTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLL
Sbjct: 378 VTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLL 437
Query: 489 VGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLR 548
VGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLR
Sbjct: 438 VGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLR 497
Query: 549 DKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLR 608
DKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLR
Sbjct: 498 DKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLR 557
Query: 609 VFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLR 668
VFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLR
Sbjct: 558 VFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLR 617
Query: 669 TPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGD 728
TPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGD
Sbjct: 618 TPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGD 677
Query: 729 GIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKG 788
GIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKG
Sbjct: 678 GIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKG 737
Query: 789 LTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGL 848
LTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGL
Sbjct: 738 LTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGL 797
Query: 849 GGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSE 908
GGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSE
Sbjct: 798 GGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSE 857
Query: 909 GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLR 968
GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLR
Sbjct: 858 GNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLR 917
Query: 969 IEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLT 1028
IEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLT
Sbjct: 918 IEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLT 977
Query: 1029 SIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAV 1088
SIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAV
Sbjct: 978 SIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAV 1037
Query: 1089 KLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITI 1148
KLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITI
Sbjct: 1038 KLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITI 1097
Query: 1149 YS 1150
YS
Sbjct: 1098 YS 1099
>gi|4827006 solute carrier family 12, member 4 isoform a [Homo
sapiens]
Length = 1085
Score = 1669 bits (4321), Expect = 0.0
Identities = 827/1058 (78%), Positives = 931/1058 (87%), Gaps = 7/1058 (0%)
Query: 99 GEHSQLLD-DGHKKARNA--YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMAN 155
GE ++L D DGH R + +L+ G +Y+D+NLALFEEE+D RPKVSSLL ++ +
Sbjct: 29 GERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVS 88
Query: 156 YTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTA 215
YTNLTQGAKEHEEAE+ +++ + P MGT MGVYLPCLQNIFGVILFLRLTW+VGTA
Sbjct: 89 YTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTA 148
Query: 216 GVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLG 275
GVLQA IVLICCCCT+LTAISMSAIATNGVVPAGGSYFMISR+LGPEFGGAVGLCFYLG
Sbjct: 149 GVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLG 208
Query: 276 TTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFI 335
TTFAAAMYILGAIEI L YI P AAIF+ A S A LNNMRVYGT FL M LVVF+
Sbjct: 209 TTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFV 268
Query: 336 GVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKE 395
GV+YVNKFASLFLACVI+SIL+IYAG IKS F PP FPVCMLGNRTLS D+C+KT
Sbjct: 269 GVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAV 328
Query: 396 INNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKG 455
++N TV ++LW FFC+S +CD YF+ NNVT I GIPG A+G++ ENLWS YL KG
Sbjct: 329 VDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKG 388
Query: 456 EIIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDA 512
+I+EK PSA + + SL YV+ DI TSFT+LVGIFFPSVTGIMAGSNRSGDL+DA
Sbjct: 389 DIVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDA 447
Query: 513 QKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVI 572
QKSIP+GTILAI+TTS VY S+VVLFGACIEGVVLRDK+GD V NLVVGTL+WPSPWVI
Sbjct: 448 QKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVI 507
Query: 573 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAEL 632
VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K NGEPTWALLLTA IAEL
Sbjct: 508 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAEL 567
Query: 633 GILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICL 692
GILIASLD+VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF+YYHWALSF+GMS+CL
Sbjct: 568 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 627
Query: 693 ALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHT 752
ALMF+SSWYYA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHT
Sbjct: 628 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 687
Query: 753 KNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQ 812
KNWRPQLLVLLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGSVI G+FLE+YGEA AAEQ
Sbjct: 688 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 747
Query: 813 TIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARA 872
TIK++ME EKVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN+VV+GWP GWRQSED RA
Sbjct: 748 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 807
Query: 873 WKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQ 932
WKTFI TVR TTAAHLALLV KNI+F+PSN E++ EG+IDVWWIVHDGGMLMLLPFLL+Q
Sbjct: 808 WKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQ 867
Query: 933 HKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTL 992
HKVWRKC +RIFTVAQ++DNSIQMKKDLA FLYHLR+EAEVEVVEMH+SDISAYTYERTL
Sbjct: 868 HKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTL 927
Query: 993 MMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKD 1052
MMEQRSQMLR MRL+KTER+REAQLVKDR+S LRL S+ SDE++E+ +K+ MTWT+D
Sbjct: 928 MMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRD 987
Query: 1053 KYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP 1112
KYM + + + F++L++++PDQSNVRRMHTAVKLNEVIV +SH+A+LVLLNMPGPP
Sbjct: 988 KYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPP 1047
Query: 1113 RNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1150
RN EGDENYMEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1048 RNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1085
>gi|225579065 solute carrier family 12, member 4 isoform d [Homo
sapiens]
Length = 1079
Score = 1665 bits (4312), Expect = 0.0
Identities = 821/1049 (78%), Positives = 925/1049 (88%), Gaps = 4/1049 (0%)
Query: 105 LDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAK 164
L G+ + + +L+ G +Y+D+NLALFEEE+D RPKVSSLL ++ +YTNLTQGAK
Sbjct: 32 LGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAK 91
Query: 165 EHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIV 224
EHEEAE+ +++ + P MGT MGVYLPCLQNIFGVILFLRLTW+VGTAGVLQA IV
Sbjct: 92 EHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIV 151
Query: 225 LICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYI 284
LICCCCT+LTAISMSAIATNGVVPAGGSYFMISR+LGPEFGGAVGLCFYLGTTFAAAMYI
Sbjct: 152 LICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYI 211
Query: 285 LGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFA 344
LGAIEI L YI P AAIF+ A S A LNNMRVYGT FL M LVVF+GV+YVNKFA
Sbjct: 212 LGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFA 271
Query: 345 SLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSK 404
SLFLACVI+SIL+IYAG IKS F PP FPVCMLGNRTLS D+C+KT ++N TV ++
Sbjct: 272 SLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQ 331
Query: 405 LWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---P 461
LW FFC+S +CD YF+ NNVT I GIPG A+G++ ENLWS YL KG+I+EK P
Sbjct: 332 LWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLP 391
Query: 462 SAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTI 521
SA + + SL YV+ DI TSFT+LVGIFFPSVTGIMAGSNRSGDL+DAQKSIP+GTI
Sbjct: 392 SADAPSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTI 450
Query: 522 LAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTC 581
LAI+TTS VY S+VVLFGACIEGVVLRDK+GD V NLVVGTL+WPSPWVIVIGSFFSTC
Sbjct: 451 LAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTC 510
Query: 582 GAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDL 641
GAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K NGEPTWALLLTA IAELGILIASLD+
Sbjct: 511 GAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDM 570
Query: 642 VAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWY 701
VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF+YYHWALSF+GMS+CLALMF+SSWY
Sbjct: 571 VAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWY 630
Query: 702 YAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLV 761
YA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLV
Sbjct: 631 YALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLV 690
Query: 762 LLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAE 821
LLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGSVI G+FLE+YGEA AAEQTIK++ME E
Sbjct: 691 LLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIE 750
Query: 822 KVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVR 881
KVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN+VV+GWP GWRQSED RAWKTFI TVR
Sbjct: 751 KVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVR 810
Query: 882 VTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSI 941
TTAAHLALLV KNI+F+PSN E++ EG+IDVWWIVHDGGMLMLLPFLL+QHKVWRKC +
Sbjct: 811 CTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRM 870
Query: 942 RIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQML 1001
RIFTVAQ++DNSIQMKKDLA FLYHLR+EAEVEVVEMH+SDISAYTYERTLMMEQRSQML
Sbjct: 871 RIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQML 930
Query: 1002 RHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQK 1061
R MRL+KTER+REAQLVKDR+S LRL S+ SDE++E+ +K+ MTWT+DKYM
Sbjct: 931 RQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDP 990
Query: 1062 AKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENY 1121
+ + + F++L++++PDQSNVRRMHTAVKLNEVIV +SH+A+LVLLNMPGPPRN EGDENY
Sbjct: 991 SHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENY 1050
Query: 1122 MEFLEVLTEGLERVLLVRGGGSEVITIYS 1150
MEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1051 MEFLEVLTEGLERVLLVRGGGREVITIYS 1079
>gi|225579067 solute carrier family 12, member 4 isoform e [Homo
sapiens]
Length = 1054
Score = 1664 bits (4310), Expect = 0.0
Identities = 820/1046 (78%), Positives = 924/1046 (88%), Gaps = 4/1046 (0%)
Query: 108 GHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHE 167
G+ + + +L+ G +Y+D+NLALFEEE+D RPKVSSLL ++ +YTNLTQGAKEHE
Sbjct: 10 GNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHE 69
Query: 168 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 227
EAE+ +++ + P MGT MGVYLPCLQNIFGVILFLRLTW+VGTAGVLQA IVLIC
Sbjct: 70 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC 129
Query: 228 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 287
CCCT+LTAISMSAIATNGVVPAGGSYFMISR+LGPEFGGAVGLCFYLGTTFAAAMYILGA
Sbjct: 130 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 189
Query: 288 IEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLF 347
IEI L YI P AAIF+ A S A LNNMRVYGT FL M LVVF+GV+YVNKFASLF
Sbjct: 190 IEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLF 249
Query: 348 LACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWG 407
LACVI+SIL+IYAG IKS F PP FPVCMLGNRTLS D+C+KT ++N TV ++LW
Sbjct: 250 LACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWS 309
Query: 408 FFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---PSAK 464
FFC+S +CD YF+ NNVT I GIPG A+G++ ENLWS YL KG+I+EK PSA
Sbjct: 310 FFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSAD 369
Query: 465 SSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAI 524
+ + SL YV+ DI TSFT+LVGIFFPSVTGIMAGSNRSGDL+DAQKSIP+GTILAI
Sbjct: 370 APSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAI 428
Query: 525 LTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAG 584
+TTS VY S+VVLFGACIEGVVLRDK+GD V NLVVGTL+WPSPWVIVIGSFFSTCGAG
Sbjct: 429 ITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAG 488
Query: 585 LQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAP 644
LQSLTGAPRLLQAIAKDNIIPFLRVFGH K NGEPTWALLLTA IAELGILIASLD+VAP
Sbjct: 489 LQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAP 548
Query: 645 ILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAI 704
ILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF+YYHWALSF+GMS+CLALMF+SSWYYA+
Sbjct: 549 ILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYAL 608
Query: 705 VAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLK 764
VAM+IAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLVLLK
Sbjct: 609 VAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLK 668
Query: 765 LDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVK 824
LDEDLHVK+PRLLTFASQLKAGKGLTIVGSVI G+FLE+YGEA AAEQTIK++ME EKVK
Sbjct: 669 LDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVK 728
Query: 825 GFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTT 884
GFCQ+VVA+K+REG++HLIQSCGLGGM+HN+VV+GWP GWRQSED RAWKTFI TVR TT
Sbjct: 729 GFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTT 788
Query: 885 AAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF 944
AAHLALLV KNI+F+PSN E++ EG+IDVWWIVHDGGMLMLLPFLL+QHKVWRKC +RIF
Sbjct: 789 AAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF 848
Query: 945 TVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHM 1004
TVAQ++DNSIQMKKDLA FLYHLR+EAEVEVVEMH+SDISAYTYERTLMMEQRSQMLR M
Sbjct: 849 TVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQM 908
Query: 1005 RLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKS 1064
RL+KTER+REAQLVKDR+S LRL S+ SDE++E+ +K+ MTWT+DKYM + +
Sbjct: 909 RLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHA 968
Query: 1065 MEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEF 1124
+ F++L++++PDQSNVRRMHTAVKLNEVIV +SH+A+LVLLNMPGPPRN EGDENYMEF
Sbjct: 969 PDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEF 1028
Query: 1125 LEVLTEGLERVLLVRGGGSEVITIYS 1150
LEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1029 LEVLTEGLERVLLVRGGGREVITIYS 1054
>gi|225579061 solute carrier family 12, member 4 isoform b [Homo
sapiens]
Length = 1079
Score = 1652 bits (4277), Expect = 0.0
Identities = 821/1058 (77%), Positives = 925/1058 (87%), Gaps = 13/1058 (1%)
Query: 99 GEHSQLLD-DGHKKARNA--YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMAN 155
GE ++L D DGH R + +L+ G +Y+D+NLALFEEE+D RPKVSSLL ++ +
Sbjct: 29 GERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVS 88
Query: 156 YTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTA 215
YTNLTQGAKEHEEAE+ +++ + P MGT MGVYLPCLQNIFGVILFLRLTW+VGTA
Sbjct: 89 YTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTA 148
Query: 216 GVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLG 275
GVLQA IVLICCCCT+LTAISMSAIATNGVVPAGGSYFMISR+LGPEFGGAVGLCFYLG
Sbjct: 149 GVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLG 208
Query: 276 TTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFI 335
TTFAAAMYILGAIEI L YI P AAIF+ A S A LNNMRVYGT FL M LVVF+
Sbjct: 209 TTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFV 268
Query: 336 GVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKE 395
GV+YVNKFASLFLACVI+SIL+IYAG IKS F PP FPVCMLGNRTLS D+C+KT
Sbjct: 269 GVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAV 328
Query: 396 INNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKG 455
++N TV ++LW FFC+S +CD YF+ NNVT I GIPG A+G++ ENLWS YL KG
Sbjct: 329 VDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKG 388
Query: 456 EIIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDA 512
+I+EK PSA + + SL YV+ DI TSFT+LVGIFFPSVTGIMAGSNRSGDL+DA
Sbjct: 389 DIVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDA 447
Query: 513 QKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVI 572
QKSIP+GTILAI+TTS VY S+VVLFGACIEGVVLRDK+GD V NLVVGTL+WPSPWVI
Sbjct: 448 QKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVI 507
Query: 573 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAEL 632
VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K NGEPTWALLLTA IAEL
Sbjct: 508 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAEL 567
Query: 633 GILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICL 692
GILIASLD+VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF+YYHWALSF+GMS+CL
Sbjct: 568 GILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCL 627
Query: 693 ALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHT 752
ALMF+SSWYYA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHT
Sbjct: 628 ALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHT 687
Query: 753 KNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQ 812
KNWRPQLLVLLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGSVI G+FLE+YGEA AAEQ
Sbjct: 688 KNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 747
Query: 813 TIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARA 872
TIK++ME EKVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN+VV+GWP GWRQSED RA
Sbjct: 748 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRA 807
Query: 873 WKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQ 932
WKTFI TVR TTAAHLALLV KNI+F+PSN E++ EG+IDVWWIVHDGGMLMLLPFLL+Q
Sbjct: 808 WKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQ 867
Query: 933 HKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTL 992
HKVWRKC +RIFTVAQ++DNSIQMKKDLA FLYHLR+EAE H+SDISAYTYERTL
Sbjct: 868 HKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE------HNSDISAYTYERTL 921
Query: 993 MMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKD 1052
MMEQRSQMLR MRL+KTER+REAQLVKDR+S LRL S+ SDE++E+ +K+ MTWT+D
Sbjct: 922 MMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRD 981
Query: 1053 KYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP 1112
KYM + + + F++L++++PDQSNVRRMHTAVKLNEVIV +SH+A+LVLLNMPGPP
Sbjct: 982 KYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPP 1041
Query: 1113 RNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1150
RN EGDENYMEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1042 RNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
>gi|225579063 solute carrier family 12, member 4 isoform c [Homo
sapiens]
Length = 1087
Score = 1641 bits (4250), Expect = 0.0
Identities = 809/1016 (79%), Positives = 905/1016 (89%), Gaps = 4/1016 (0%)
Query: 138 EEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQ 197
EE+D RPKVSSLL ++ +YTNLTQGAKEHEEAE+ +++ + P MGT MGVYLPCLQ
Sbjct: 73 EELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQ 132
Query: 198 NIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMIS 257
NIFGVILFLRLTW+VGTAGVLQA IVLICCCCT+LTAISMSAIATNGVVPAGGSYFMIS
Sbjct: 133 NIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMIS 192
Query: 258 RALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNN 317
R+LGPEFGGAVGLCFYLGTTFAAAMYILGAIEI L YI P AAIF+ A S A LNN
Sbjct: 193 RSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNN 252
Query: 318 MRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCML 377
MRVYGT FL M LVVF+GV+YVNKFASLFLACVI+SIL+IYAG IKS F PP FPVCML
Sbjct: 253 MRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCML 312
Query: 378 GNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPG 437
GNRTLS D+C+KT ++N TV ++LW FFC+S +CD YF+ NNVT I GIPG
Sbjct: 313 GNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
Query: 438 LASGIITENLWSNYLPKGEIIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFP 494
A+G++ ENLWS YL KG+I+EK PSA + + SL YV+ DI TSFT+LVGIFFP
Sbjct: 373 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFP 431
Query: 495 SVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDA 554
SVTGIMAGSNRSGDL+DAQKSIP+GTILAI+TTS VY S+VVLFGACIEGVVLRDK+GD
Sbjct: 432 SVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDG 491
Query: 555 VKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSK 614
V NLVVGTL+WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH K
Sbjct: 492 VSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGK 551
Query: 615 ANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRP 674
NGEPTWALLLTA IAELGILIASLD+VAPILSMFFLMCYLFVNLACA+QTLLRTPNWRP
Sbjct: 552 VNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRP 611
Query: 675 RFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLS 734
RF+YYHWALSF+GMS+CLALMF+SSWYYA+VAM+IAGMIYKYIEYQGAEKEWGDGIRGLS
Sbjct: 612 RFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLS 671
Query: 735 LSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGS 794
LSAAR+ALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVK+PRLLTFASQLKAGKGLTIVGS
Sbjct: 672 LSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGS 731
Query: 795 VIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHN 854
VI G+FLE+YGEA AAEQTIK++ME EKVKGFCQ+VVA+K+REG++HLIQSCGLGGM+HN
Sbjct: 732 VIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHN 791
Query: 855 TVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVW 914
+VV+GWP GWRQSED RAWKTFI TVR TTAAHLALLV KNI+F+PSN E++ EG+IDVW
Sbjct: 792 SVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVW 851
Query: 915 WIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVE 974
WIVHDGGMLMLLPFLL+QHKVWRKC +RIFTVAQ++DNSIQMKKDLA FLYHLR+EAEVE
Sbjct: 852 WIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVE 911
Query: 975 VVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDE 1034
VVEMH+SDISAYTYERTLMMEQRSQMLR MRL+KTER+REAQLVKDR+S LRL S+ SDE
Sbjct: 912 VVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDE 971
Query: 1035 DEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVI 1094
++E+ +K+ MTWT+DKYM + + + F++L++++PDQSNVRRMHTAVKLNEVI
Sbjct: 972 EDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVI 1031
Query: 1095 VNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1150
V +SH+A+LVLLNMPGPPRN EGDENYMEFLEVLTEGLERVLLVRGGG EVITIYS
Sbjct: 1032 VTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
>gi|198041678 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 1 [Homo sapiens]
Length = 1139
Score = 1555 bits (4025), Expect = 0.0
Identities = 775/1099 (70%), Positives = 897/1099 (81%), Gaps = 56/1099 (5%)
Query: 107 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 166
DG+ K + ++N+++ E+G EY KN+ALFEEEMDT P VSSLL+ +ANYTNL QG++EH
Sbjct: 42 DGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREH 101
Query: 167 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 226
EEAEN GKKKP + P+MGTFMGVYLPCLQNIFGVILFLRLTWVVG AG++++F +V I
Sbjct: 102 EEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFI 161
Query: 227 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 286
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 162 CCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 221
Query: 287 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 346
IEI L Y+ P AIF ++DA E+AAMLNNMRVYGT L M VVF+GV+YVNKFA +
Sbjct: 222 TIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALV 281
Query: 347 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 406
FL CVI+SILAIYAG IKS+F PP+FP+C+LGNRTLS DVC+K N TV ++LW
Sbjct: 282 FLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLW 341
Query: 407 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSS 466
G FC SS+F NATCDEYF NNVT IQGIPG ASG+I ENLWS+YL KG I+E+ S
Sbjct: 342 GLFC-SSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 400
Query: 467 DVLGS----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTIL 522
+ ++H YV D+T+ FTLLVGI+FPSVTGIMAGSNRSGDL+DAQKSIP GTIL
Sbjct: 401 GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 460
Query: 523 AILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCG 582
AI TTS VY+S+VVLFGACIEGVVLRDKFG+AV GNLVVGTL+WPSPWVIVIGSFFSTCG
Sbjct: 461 AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 520
Query: 583 AGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLV 642
AGLQSLTGAPRLLQAI++D I+PFL+VFGH KANGEPTWALLLTA I E+GILIASLD V
Sbjct: 521 AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 580
Query: 643 APILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYY 702
APILSMFFLMCY+FVNLACA+QTLLRTPNWRPRFRYYHW LSF+GMS+CLALMFI SWYY
Sbjct: 581 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 640
Query: 703 AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVL 762
A+VAM+IAG+IYKYIEY+GAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLVL
Sbjct: 641 ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 700
Query: 763 LKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEK 822
+++D+D +V HP+LL+ SQLKAGKGLTIVGSV+ G FLEN+ +A AE++I+ LMEAEK
Sbjct: 701 VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 760
Query: 823 VKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRV 882
VKGFCQ+V+++ LR+G+SHLIQS GLGG++HNTV++GWP WRQ ED + W+ FI VR
Sbjct: 761 VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 820
Query: 883 TTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIR 942
TTA HLALLV KN+S FP N E+FSEG+IDVWWIVHDGGMLMLLPFLL+ HKVWRKC +R
Sbjct: 821 TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 880
Query: 943 IFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLR 1002
IFTVAQ++DNSIQMKKDL TFLYHLRI AEVEVVEMH+SDISAYTYE+TL+MEQRSQ+L+
Sbjct: 881 IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 940
Query: 1003 HMRLSKTERDREAQLVKDR-----------NSMLRLT----------------------- 1028
M L+K ER+RE Q + D N+ LRL
Sbjct: 941 QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 1000
Query: 1029 ----------SIGSDEDEETETYQEKVHMTWTKDKYMA--SRGQKAKSMEGFQDLLNMRP 1076
S G + + E ET EKVH+TWTKDK +A ++G S EG +D +M+P
Sbjct: 1001 SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1060
Query: 1077 D-----QSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEG 1131
+ QSNVRRMHTAV+LNEVIV KS +AKLVLLNMPGPPRN GDENYMEFLEVLTE
Sbjct: 1061 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1120
Query: 1132 LERVLLVRGGGSEVITIYS 1150
L+RV+LVRGGG EVITIYS
Sbjct: 1121 LDRVMLVRGGGREVITIYS 1139
>gi|11968148 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 2 [Homo sapiens]
Length = 1116
Score = 1555 bits (4025), Expect = 0.0
Identities = 775/1099 (70%), Positives = 897/1099 (81%), Gaps = 56/1099 (5%)
Query: 107 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 166
DG+ K + ++N+++ E+G EY KN+ALFEEEMDT P VSSLL+ +ANYTNL QG++EH
Sbjct: 19 DGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREH 78
Query: 167 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 226
EEAEN GKKKP + P+MGTFMGVYLPCLQNIFGVILFLRLTWVVG AG++++F +V I
Sbjct: 79 EEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFI 138
Query: 227 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 286
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 139 CCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 198
Query: 287 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 346
IEI L Y+ P AIF ++DA E+AAMLNNMRVYGT L M VVF+GV+YVNKFA +
Sbjct: 199 TIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALV 258
Query: 347 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 406
FL CVI+SILAIYAG IKS+F PP+FP+C+LGNRTLS DVC+K N TV ++LW
Sbjct: 259 FLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLW 318
Query: 407 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSS 466
G FC SS+F NATCDEYF NNVT IQGIPG ASG+I ENLWS+YL KG I+E+ S
Sbjct: 319 GLFC-SSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSV 377
Query: 467 DVLGS----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTIL 522
+ ++H YV D+T+ FTLLVGI+FPSVTGIMAGSNRSGDL+DAQKSIP GTIL
Sbjct: 378 GLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTIL 437
Query: 523 AILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCG 582
AI TTS VY+S+VVLFGACIEGVVLRDKFG+AV GNLVVGTL+WPSPWVIVIGSFFSTCG
Sbjct: 438 AIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCG 497
Query: 583 AGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLV 642
AGLQSLTGAPRLLQAI++D I+PFL+VFGH KANGEPTWALLLTA I E+GILIASLD V
Sbjct: 498 AGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEV 557
Query: 643 APILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYY 702
APILSMFFLMCY+FVNLACA+QTLLRTPNWRPRFRYYHW LSF+GMS+CLALMFI SWYY
Sbjct: 558 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYY 617
Query: 703 AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVL 762
A+VAM+IAG+IYKYIEY+GAEKEWGDGIRGLSLSAAR+ALLRLEEGPPHTKNWRPQLLVL
Sbjct: 618 ALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVL 677
Query: 763 LKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEK 822
+++D+D +V HP+LL+ SQLKAGKGLTIVGSV+ G FLEN+ +A AE++I+ LMEAEK
Sbjct: 678 VRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEK 737
Query: 823 VKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRV 882
VKGFCQ+V+++ LR+G+SHLIQS GLGG++HNTV++GWP WRQ ED + W+ FI VR
Sbjct: 738 VKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRE 797
Query: 883 TTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIR 942
TTA HLALLV KN+S FP N E+FSEG+IDVWWIVHDGGMLMLLPFLL+ HKVWRKC +R
Sbjct: 798 TTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMR 857
Query: 943 IFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLR 1002
IFTVAQ++DNSIQMKKDL TFLYHLRI AEVEVVEMH+SDISAYTYE+TL+MEQRSQ+L+
Sbjct: 858 IFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILK 917
Query: 1003 HMRLSKTERDREAQLVKDR-----------NSMLRLT----------------------- 1028
M L+K ER+RE Q + D N+ LRL
Sbjct: 918 QMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQ 977
Query: 1029 ----------SIGSDEDEETETYQEKVHMTWTKDKYMA--SRGQKAKSMEGFQDLLNMRP 1076
S G + + E ET EKVH+TWTKDK +A ++G S EG +D +M+P
Sbjct: 978 SAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKP 1037
Query: 1077 D-----QSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEG 1131
+ QSNVRRMHTAV+LNEVIV KS +AKLVLLNMPGPPRN GDENYMEFLEVLTE
Sbjct: 1038 EWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEH 1097
Query: 1132 LERVLLVRGGGSEVITIYS 1150
L+RV+LVRGGG EVITIYS
Sbjct: 1098 LDRVMLVRGGGREVITIYS 1116
>gi|123701900 solute carrier family 12 (potassium/chloride
transporters), member 7 [Homo sapiens]
Length = 1083
Score = 1512 bits (3915), Expect = 0.0
Identities = 749/1048 (71%), Positives = 869/1048 (82%), Gaps = 11/1048 (1%)
Query: 107 DGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEH 166
DG+ + + +LNN E+ + KN+ALFEEEMD+ P VSSLLN++ANYTNL+QG EH
Sbjct: 43 DGNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEH 102
Query: 167 EEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLI 226
EE E E +++ K P+MGTF+GVYLPCLQNI GVILFLRLTW+VG AGVL++F IV +
Sbjct: 103 EEDE---ESRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAM 159
Query: 227 CCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILG 286
CC CTMLTAISMSAIATNGVVPAGGSY+MISR+LGPEFGGAVGLCFYLGTTFA AMYILG
Sbjct: 160 CCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 219
Query: 287 AIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 346
IEIFL YI P AAIF ++ A E+AAML+NMRVYGT LVLM LVVF+GV+YVNK A +
Sbjct: 220 TIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALV 279
Query: 347 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLW 406
FLACV++SILAIYAG IKS+F PP PVC+LGNRTLS R D C K I+N + S LW
Sbjct: 280 FLACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALW 339
Query: 407 GFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---PSA 463
G FCN SQ +A CDEYF+ NNVT IQGIPG ASG+ ENLWS Y G +EK PS
Sbjct: 340 GLFCNGSQP-SAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSV 398
Query: 464 KSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILA 523
++ + YVL DI SFTLLVGI+FPSVTGIMAGSNRSGDLKDAQKSIP GTILA
Sbjct: 399 PVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILA 458
Query: 524 ILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGA 583
I+TTSF+YLS +VLFGACIEGVVLRDKFG+A++GNLV+G L+WPSPWVIVIGSFFSTCGA
Sbjct: 459 IVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGA 518
Query: 584 GLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVA 643
GLQSLTGAPRLLQAIA+D I+PFL+VFGH KANGEPTWALLLT I E GILIASLD VA
Sbjct: 519 GLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVA 578
Query: 644 PILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYA 703
PILSMFFLMCYLFVNLACA+QTLLRTPNWRPRF++YHW LSF+GMS+CLALMFI SWYYA
Sbjct: 579 PILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYA 638
Query: 704 IVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLL 763
+ AM+IAG IYKYIEY+GAEKEWGDGIRGLSL+AAR+ALLR+E GPPHTKNWRPQ+LV+L
Sbjct: 639 LSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVML 698
Query: 764 KLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKV 823
LD + VKHPRLL+F SQLKAGKGLTIVGSV+ G +L+ + EA AE+ I+ LM EK
Sbjct: 699 NLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKT 758
Query: 824 KGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVT 883
KGFCQLVV++ LR+G+SHLIQS GLGG+KHNTV+M WP W+Q ++ +WK F+ TVR T
Sbjct: 759 KGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDT 818
Query: 884 TAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRI 943
TAAH ALLVAKN+ FP N E+F G+IDVWWIVHDGGMLMLLPFLL+QHKVWRKC +RI
Sbjct: 819 TAAHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRI 878
Query: 944 FTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRH 1003
FTVAQ++DNSIQMKKDL FLYHLRI AEVEVVEM ++DISA+TYERTLMMEQRSQML+
Sbjct: 879 FTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQ 938
Query: 1004 MRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR-GQKA 1062
M+LSK E++REAQL+ DRN+ + + T +KV MTWT++K +A + +
Sbjct: 939 MQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPT---PDKVQMTWTREKLIAEKYRSRD 995
Query: 1063 KSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYM 1122
S+ GF+DL +M+PDQSNVRRMHTAVKLN V++NKS +A+LVLLNMPGPP+N +GDENYM
Sbjct: 996 TSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYM 1055
Query: 1123 EFLEVLTEGLERVLLVRGGGSEVITIYS 1150
EFLEVLTEGL RVLLVRGGG EVITIYS
Sbjct: 1056 EFLEVLTEGLNRVLLVRGGGREVITIYS 1083
>gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo
sapiens]
Length = 1021
Score = 239 bits (610), Expect = 1e-62
Identities = 199/743 (26%), Positives = 328/743 (44%), Gaps = 139/743 (18%)
Query: 484 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 543
+F + IFFPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C
Sbjct: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 396
Query: 544 GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 570
V+RD G + + G T+S S +
Sbjct: 397 --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 453
Query: 571 --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 627
+I G F +T + L L A ++ Q + +D + P + FG N EP LL
Sbjct: 454 APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 513
Query: 628 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 687
AIA I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G
Sbjct: 514 AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 573
Query: 688 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 747
I + +MF+ +W+ A++A+ + + Y+ Y+ E WG ++ S + A + L E
Sbjct: 574 AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 633
Query: 748 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 807
H KN+RPQ LVL P L+ F L I G V++G + E
Sbjct: 634 VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 689
Query: 808 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 867
+ K+K F V+A LR G+ L+Q+ GLG MK N +V+G+ W+ +
Sbjct: 690 QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 749
Query: 868 EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 900
A + +IG +R+ +++ ++ +I+ F P
Sbjct: 750 HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARVD 808
Query: 901 ----------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQ 948
+ + Q +G ID++W+ DGG+ +L+P+LL + + W KC IR+F Q
Sbjct: 809 PKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQ 868
Query: 949 LEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLS 1007
+ + Q +K + + L R+ EV ++ + + A E T E M+ RL+
Sbjct: 869 I-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE---DMIAPFRLN 921
Query: 1008 KTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEG 1067
+D R+ +++ DEE TK++ + R
Sbjct: 922 DGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR--------- 955
Query: 1068 FQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEV 1127
V+LNE++++ S +A L+++ +P + YM +LE
Sbjct: 956 -------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLET 996
Query: 1128 LTEGLE-RVLLVRGGGSEVITIY 1149
L++ L V+L+RG V+T Y
Sbjct: 997 LSQDLRPPVILIRGNQENVLTFY 1019
Score = 123 bits (308), Expect = 1e-27
Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)
Query: 168 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 227
E E T +K P + + G GV + C+ NI+GVIL+LRL W+ AG++ + I+L+
Sbjct: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
Query: 228 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 287
T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F AM+ +G
Sbjct: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
Query: 288 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 343
E D L+E A +N++R+ G + +++ + G+ + +K
Sbjct: 239 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 285
Query: 344 ASLFLACVIVSILAIYAGAIKSSFAPP 370
LF ++VS +A + + PP
Sbjct: 286 QVLFFLVIMVS----FANYLVGTLIPP 308
>gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo
sapiens]
Length = 1029
Score = 236 bits (601), Expect = 1e-61
Identities = 199/752 (26%), Positives = 328/752 (43%), Gaps = 148/752 (19%)
Query: 484 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 543
+F + IFFPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C
Sbjct: 338 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 395
Query: 544 GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 570
V+RD G + + G T+S S +
Sbjct: 396 --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 452
Query: 571 --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 627
+I G F +T + L L A ++ Q + +D + P + FG N EP LL
Sbjct: 453 APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 512
Query: 628 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 687
AIA I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G
Sbjct: 513 AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 572
Query: 688 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 747
I + +MF+ +W+ A++A+ + + Y+ Y+ E WG ++ S + A + L E
Sbjct: 573 AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 632
Query: 748 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 807
H KN+RPQ LVL P L+ F L I G V++G + E
Sbjct: 633 VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 688
Query: 808 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 867
+ K+K F V+A LR G+ L+Q+ GLG MK N +V+G+ W+ +
Sbjct: 689 QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 748
Query: 868 EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 900
A + +IG +R+ +++ ++ +I+ F P
Sbjct: 749 HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGA 807
Query: 901 -------------------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKC 939
+ + Q +G ID++W+ DGG+ +L+P+LL + + W KC
Sbjct: 808 RPSVSGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKC 867
Query: 940 SIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRS 998
IR+F Q+ + Q +K + + L R+ EV ++ + + A E T E
Sbjct: 868 KIRVFVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE--- 920
Query: 999 QMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR 1058
M+ RL+ +D R+ +++ DEE TK++ + R
Sbjct: 921 DMIAPFRLNDGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR 963
Query: 1059 GQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGD 1118
V+LNE++++ S +A L+++ +P +
Sbjct: 964 ----------------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPS 995
Query: 1119 ENYMEFLEVLTEGLE-RVLLVRGGGSEVITIY 1149
YM +LE L++ L V+L+RG V+T Y
Sbjct: 996 SLYMAWLETLSQDLRPPVILIRGNQENVLTFY 1027
Score = 123 bits (308), Expect = 1e-27
Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)
Query: 168 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 227
E E T +K P + + G GV + C+ NI+GVIL+LRL W+ AG++ + I+L+
Sbjct: 118 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 177
Query: 228 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 287
T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F AM+ +G
Sbjct: 178 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 237
Query: 288 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 343
E D L+E A +N++R+ G + +++ + G+ + +K
Sbjct: 238 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 284
Query: 344 ASLFLACVIVSILAIYAGAIKSSFAPP 370
LF ++VS +A + + PP
Sbjct: 285 QVLFFLVIMVS----FANYLVGTLIPP 307
>gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo
sapiens]
Length = 1030
Score = 236 bits (601), Expect = 1e-61
Identities = 199/752 (26%), Positives = 328/752 (43%), Gaps = 148/752 (19%)
Query: 484 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 543
+F + IFFPS TGI+AG+N SGDLKD +IP GT++AI T+ YL+ G+C
Sbjct: 339 TFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSC-- 396
Query: 544 GVVLRDKFGDAVKGNLVVG---------------------------------TLSWPSPW 570
V+RD G + + G T+S S +
Sbjct: 397 --VVRDASG-VLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGF 453
Query: 571 --VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKA-NGEPTWALLLTA 627
+I G F +T + L L A ++ Q + +D + P + FG N EP LL
Sbjct: 454 APLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAY 513
Query: 628 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 687
AIA I+IA L+ +API+S FFL Y +N +C ++ +P WRP F+YY+ + G
Sbjct: 514 AIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFG 573
Query: 688 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 747
I + +MF+ +W+ A++A+ + + Y+ Y+ E WG ++ S + A + L E
Sbjct: 574 AIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNE 633
Query: 748 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 807
H KN+RPQ LVL P L+ F L I G V++G + E
Sbjct: 634 VEDHIKNYRPQCLVLTGPPN----FRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 689
Query: 808 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 867
+ K+K F V+A LR G+ L+Q+ GLG MK N +V+G+ W+ +
Sbjct: 690 QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 749
Query: 868 EDARAWKTFIG-------------TVRVTTAAHLALLVAKNIS--FFP------------ 900
A + +IG +R+ +++ ++ +I+ F P
Sbjct: 750 HPATV-EDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARGA 808
Query: 901 -------------------SNVEQFSEG--NIDVWWIVHDGGMLMLLPFLLKQHKVWRKC 939
+ + Q +G ID++W+ DGG+ +L+P+LL + + W KC
Sbjct: 809 RPSVSGALDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKC 868
Query: 940 SIRIFTVAQLEDNSIQMKKDLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMMEQRS 998
IR+F Q+ + Q +K + + L R+ EV ++ + + A E T E
Sbjct: 869 KIRVFVGGQI-NRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRA---EHTKRFE--- 921
Query: 999 QMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASR 1058
M+ RL+ +D R+ +++ DEE TK++ + R
Sbjct: 922 DMIAPFRLNDGFKDEATVNEMRRDCPWKIS------DEEI-----------TKNRVKSLR 964
Query: 1059 GQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGD 1118
V+LNE++++ S +A L+++ +P +
Sbjct: 965 ----------------------------QVRLNEIVLDYSRDAALIVITLPIGRKGKCPS 996
Query: 1119 ENYMEFLEVLTEGLE-RVLLVRGGGSEVITIY 1149
YM +LE L++ L V+L+RG V+T Y
Sbjct: 997 SLYMAWLETLSQDLRPPVILIRGNQENVLTFY 1028
Score = 123 bits (308), Expect = 1e-27
Identities = 69/207 (33%), Positives = 112/207 (54%), Gaps = 21/207 (10%)
Query: 168 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC 227
E E T +K P + + G GV + C+ NI+GVIL+LRL W+ AG++ + I+L+
Sbjct: 119 EGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLS 178
Query: 228 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA 287
T +T +S+SAI+TNG V +GG+YF+ISR+LGPE GG++GL F AM+ +G
Sbjct: 179 VTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGF 238
Query: 288 IEIFLVYIVPRAAIFHSDDALKESAA----MLNNMRVYGTAFLVLMVLVVFIGVRYVNKF 343
E D L+E A +N++R+ G + +++ + G+ + +K
Sbjct: 239 AETV-------------RDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKA 285
Query: 344 ASLFLACVIVSILAIYAGAIKSSFAPP 370
LF ++VS +A + + PP
Sbjct: 286 QVLFFLVIMVS----FANYLVGTLIPP 308
>gi|4506975 solute carrier family 12 (sodium/potassium/chloride
transporters), member 2 [Homo sapiens]
Length = 1212
Score = 223 bits (567), Expect = 1e-57
Identities = 147/421 (34%), Positives = 215/421 (51%), Gaps = 46/421 (10%)
Query: 484 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 543
+F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAIL T+ VY+ V G+C
Sbjct: 486 TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSC-- 543
Query: 544 GVVLRDKFGD---------------AVKGNL-------------------VVGTLSWPSP 569
V+RD G+ A K N V+ +S +P
Sbjct: 544 --VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTP 601
Query: 570 WVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWALLLTA 627
+I G F +T + L SL AP++ QA+ KDNI P ++F G+ K N EP +LT
Sbjct: 602 -LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLRGYILTF 659
Query: 628 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 687
IA ILIA L+++API+S FFL Y +N + +L ++P WRP F+YY+ +S +G
Sbjct: 660 LIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLG 719
Query: 688 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 747
+C +MF+ +W+ A++ VI +Y Y+ Y+ + WG + L+ A +RL
Sbjct: 720 AILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSG 779
Query: 748 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 807
H KN+RPQ LV+ P LL GL I G V +G + E
Sbjct: 780 VEDHVKNFRPQCLVMTGAPN----SRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEM 835
Query: 808 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 867
+ + + K+K F V A LREG +L+Q+ GLG MK NT+V+G+ W Q+
Sbjct: 836 SIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQA 895
Query: 868 E 868
+
Sbjct: 896 D 896
Score = 122 bits (307), Expect = 1e-27
Identities = 91/339 (26%), Positives = 161/339 (47%), Gaps = 43/339 (12%)
Query: 36 SSRSSSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQN 95
S + R R + + +S + +S+ +G V +D P+ + D + LS+
Sbjct: 132 SEEAKGRFRVNFVDPAASSSAEDSLSDAAG-------VGVDGPNVSFQNGGDTV--LSEG 182
Query: 96 SI--------TGEHSQLLDDGHKKARNAYLNNSNYEEGD-----EYFDKNLALFEEEMDT 142
S +G H D H YL + D +++ A E++
Sbjct: 183 SSLHSGGGGGSGHHQHYYYDTH--TNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKL-L 239
Query: 143 RPKVSSLLNRMAN------YTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCL 196
RP ++ L + + + N + + T K K G GV + C+
Sbjct: 240 RPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVK---FGWIKGVLVRCM 296
Query: 197 QNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMI 256
NI+GV+LF+RL+W+VG AG+ + ++++ T +T +S SAIATNG V GG+Y++I
Sbjct: 297 LNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLI 356
Query: 257 SRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLN 316
SR+LGPEFGGA+GL F A AMY++G E +V ++ +I D+ +N
Sbjct: 357 SRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAET-VVELLKEHSILMIDE--------IN 407
Query: 317 NMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSI 355
++R+ G +V+++ + G+ + K + L ++++I
Sbjct: 408 DIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
Score = 76.6 bits (187), Expect = 1e-13
Identities = 58/245 (23%), Positives = 110/245 (44%), Gaps = 55/245 (22%)
Query: 908 EGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQM-KKDLATFLYH 966
+ IDVWW+ DGG+ +L+P+LL K W+ C IR+F ++ N I ++ +AT L
Sbjct: 1021 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSK 1078
Query: 967 LRIE-AEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSML 1025
RI+ +++ V+ DI+ + ++ + +++ RL + +++++ +
Sbjct: 1079 FRIDFSDIMVL----GDINTKPKKENIIAFE--EIIEPYRLHEDDKEQDIADKMKEDEPW 1132
Query: 1026 RLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMH 1085
R+T D E E Y+ K +
Sbjct: 1133 RIT------DNELELYKTKT---------------------------------------Y 1147
Query: 1086 TAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEV 1145
++LNE++ S A ++++++P + YM +LE L++ L +LLVRG V
Sbjct: 1148 RQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSV 1207
Query: 1146 ITIYS 1150
+T YS
Sbjct: 1208 LTFYS 1212
>gi|134254459 sodium potassium chloride cotransporter 2 [Homo
sapiens]
Length = 1099
Score = 211 bits (538), Expect = 2e-54
Identities = 142/421 (33%), Positives = 207/421 (49%), Gaps = 50/421 (11%)
Query: 485 FTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEG 544
F + IFFP+ TGI+AG+N SGDL+D Q +IP GT+LAI T+ YL + GAC
Sbjct: 380 FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGAC--- 436
Query: 545 VVLRDKFGDA---------VKGNLVVG----------------------TLSWPSPW--V 571
V+RD G+ G+ G +S S + +
Sbjct: 437 -VVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPL 495
Query: 572 IVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWALLLTAAI 629
I G F +T + L SL AP++ QA+ KDNI L+ F G+ K N EP +LT I
Sbjct: 496 ITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGK-NNEPLRGYILTFLI 554
Query: 630 AELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMS 689
A ILIA L+ +API+S FFL Y +N +C + ++P WRP + Y+ +S G
Sbjct: 555 AMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAV 614
Query: 690 ICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGP 749
+C A+MF+ +W+ A++ VI +Y Y+ + + WG + LS +A L L
Sbjct: 615 LCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVE 674
Query: 750 PHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGN---FLENYGE 806
H KN+RPQ +VL + P LL GL I V VG ++
Sbjct: 675 DHVKNFRPQCIVL----TGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNS 730
Query: 807 ALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQ 866
+A +Q + K+K F V A R+G+ L+Q+ GLG MK NT+V+G+ WR+
Sbjct: 731 GMAKKQA---WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRK 787
Query: 867 S 867
+
Sbjct: 788 A 788
Score = 132 bits (331), Expect = 2e-30
Identities = 83/253 (32%), Positives = 135/253 (53%), Gaps = 25/253 (9%)
Query: 116 YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVS-SLLNRMANYTNLTQGAKEHEEAENITE 174
Y N+ G + +L E++ V+ S +R+AN G E+AEN +
Sbjct: 114 YYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVAN----GDGIPGDEQAENKED 169
Query: 175 GKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLT 234
+ K G GV + C+ NI+GV+LF+RL+W+VG AG+ I+L+ T +T
Sbjct: 170 DQAGVVK---FGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSIT 226
Query: 235 AISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVY 294
+S SAIATNG V GG+Y++ISR+LGPEFGG++GL F A AMY++G E +
Sbjct: 227 GLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVV-- 284
Query: 295 IVPRAAIFHSDDALKESAAML----NNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLAC 350
D LKES +M+ N++R+ G+ +V+++ + G+ + K + L
Sbjct: 285 -----------DLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVI 333
Query: 351 VIVSILAIYAGAI 363
++++I + G +
Sbjct: 334 LLIAIANFFIGTV 346
Score = 85.5 bits (210), Expect = 3e-16
Identities = 68/275 (24%), Positives = 124/275 (45%), Gaps = 55/275 (20%)
Query: 878 GTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWR 937
G++ + + H+ K + ++ +G IDVWW+ DGG+ +L+P++L K W+
Sbjct: 878 GSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWK 937
Query: 938 KCSIRIFTVAQLEDNSIQMKK-DLATFLYHLRIE-AEVEVVEMHDSDISAYTYERTLMME 995
C +RI+ ++ N I+ +K +A+ L RI+ A++ ++ DI+ + + +
Sbjct: 938 DCKLRIYVGGKI--NRIEEEKIVMASLLSKFRIKFADIHII----GDINIRPNKESWKVF 991
Query: 996 QRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYM 1055
+ +M+ RL ++ +D R + ++T D E E +EK
Sbjct: 992 E--EMIEPYRLHESCKDLTTAEKLKRETPWKIT------DAELEAVKEK----------- 1032
Query: 1056 ASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNP 1115
+ V+LNE++ S A L++L++P +
Sbjct: 1033 ----------------------------SYRQVRLNELLQEHSRAANLIVLSLPVARKGS 1064
Query: 1116 EGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1150
D YM +LE+LT+ L VLLVRG V+T YS
Sbjct: 1065 ISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
>gi|31881740 solute carrier family 12 (potassium/chloride
transporters), member 9 [Homo sapiens]
Length = 914
Score = 195 bits (496), Expect = 2e-49
Identities = 130/412 (31%), Positives = 214/412 (51%), Gaps = 37/412 (8%)
Query: 462 SAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTI 521
S+ D LG+ E +F + + F TGIMAG+N SG+LKD ++IP+GTI
Sbjct: 244 SSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTI 303
Query: 522 LAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTC 581
+A+ T FVY+ L + +L++ +G +L WP +++IG + +
Sbjct: 304 VAVAYTFFVYVLLFFLSSFTCDRTLLQEDYGFFRAISL------WPP--LVLIGIYATAL 355
Query: 582 GAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTA-AIAELGILIASLD 640
A + SL GA R+L A+A+D++ + + G WA +L + + +L +L L+
Sbjct: 356 SASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLN 415
Query: 641 LVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSW 700
+A ++++F+L+ Y V+L+C PN+RP F + W +G++ CL +MF+ S
Sbjct: 416 TLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISP 475
Query: 701 YYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLL 760
A ++++ G++ + +G WG + L R LLRL+ H K WRPQLL
Sbjct: 476 GAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLL 535
Query: 761 VLLKLDEDLHVKHPR----LLTFASQLKAGKGLTIVGSVIVGNF--------LENYGEAL 808
+L V +PR LL A+QLK G GL ++G V +G+ YG L
Sbjct: 536 LL--------VGNPRGALPLLRLANQLKKG-GLYVLGHVTLGDLDSLPSDPVQPQYGAWL 586
Query: 809 AAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGW 860
+ L++ +VK F L ++ +R+G HL++ GLGGMK NT+V+G+
Sbjct: 587 S-------LVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGF 631
Score = 112 bits (279), Expect = 3e-24
Identities = 53/109 (48%), Positives = 77/109 (70%)
Query: 184 QMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIAT 243
++ TF+GV +P + ++F +++FLR+ +VVG AG+LQA A++L+ LT +S+ AIAT
Sbjct: 36 KLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIAT 95
Query: 244 NGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFL 292
NG V GG+YFMISR LGPE GG++GL FYL A+ +LG +E L
Sbjct: 96 NGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVL 144
Score = 31.6 bits (70), Expect = 4.5
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 1103 LVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRG 1140
L L +P PP +P Y+ LE LT L LLV G
Sbjct: 868 LTFLYLPRPPADPARYPRYLALLETLTRDLGPTLLVHG 905
>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
Length = 714
Score = 104 bits (260), Expect = 4e-22
Identities = 59/176 (33%), Positives = 102/176 (57%), Gaps = 9/176 (5%)
Query: 484 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 543
SF + G+FFP+ TG+MAG N GDL++ SIP+G++ A+ + F+Y+ V L GA
Sbjct: 232 SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICT 291
Query: 544 GVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 603
LR F A K +L+ ++ ++G + S+ + + L GAPR+LQ IA++ +
Sbjct: 292 REALRYDFLIAEKVSLM--------GFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKV 343
Query: 604 IPFLRVFGHSKA-NGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVN 658
IP L G K N P A+ LT+ + + + ++++API+++ F++ Y+ V+
Sbjct: 344 IPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVD 399
Score = 90.9 bits (224), Expect = 6e-18
Identities = 62/207 (29%), Positives = 94/207 (45%), Gaps = 27/207 (13%)
Query: 166 HEEAENITEGKKKPTKTPQM--------GTFMGVYLPCLQNIFGVILFLRLTWVVGTAGV 217
HE A+ + +P Q+ GT+ GV+ C+ NIFGV+LFLR W+VG GV
Sbjct: 12 HEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGV 71
Query: 218 LQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTT 277
L +V ++T +S + + +GG Y MIS LG + GG +GL + G
Sbjct: 72 LLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQC 131
Query: 278 FAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVL--VVFI 335
A AMYI G E ++ + + N V G + VL+ L +
Sbjct: 132 VAGAMYITGFAE-----------------SISDLLGLGNIWAVRGISVAVLLALLGINLA 174
Query: 336 GVRYVNKFASLFLACVIVSILAIYAGA 362
GV+++ + L L + VS L G+
Sbjct: 175 GVKWIIRLQLLLLFLLAVSTLDFVVGS 201
Score = 33.1 bits (74), Expect = 1.6
Identities = 25/79 (31%), Positives = 36/79 (45%), Gaps = 16/79 (20%)
Query: 672 WRPRFRYYH-----WALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEW 726
WR +Y W +S +G L +MF+ W Y +V M +A ++Y YI
Sbjct: 582 WRRSTSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI--------- 631
Query: 727 GDGIRGLSL-SAARFALLR 744
G GL L SA+ F+ R
Sbjct: 632 GRASPGLHLGSASNFSFFR 650
>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
sapiens]
Length = 697
Score = 47.0 bits (110), Expect = 1e-04
Identities = 51/211 (24%), Positives = 83/211 (39%), Gaps = 21/211 (9%)
Query: 459 EKPSAKSSDVLGS-----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQ 513
E PS + + G+ L T F VG + TG ++++ Q
Sbjct: 274 EPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTG--------EEVRNPQ 325
Query: 514 KSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSW-PSPWVI 572
K+IPIG + ++L Y + +L +K V V W P+ +V+
Sbjct: 326 KAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVV 381
Query: 573 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAEL 632
GS + + L S+ PR+L A+A+D ++ R P A L I+ L
Sbjct: 382 AAGSLCALSTSLLGSMFPLPRILFAMARDGLL--FRFLARVSKRQSPVAATLTAGVISAL 439
Query: 633 GILIASLDLVAPILSMFFLMCYLFVNLACAL 663
+ L + ++S+ LM Y V AC L
Sbjct: 440 MAFLFDLKALVDMMSIGTLMAYSLV-AACVL 469
>gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo
sapiens]
Length = 658
Score = 45.8 bits (107), Expect = 2e-04
Identities = 51/211 (24%), Positives = 87/211 (41%), Gaps = 20/211 (9%)
Query: 459 EKPSAKSSDVLGS-----LNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQ 513
E PS + + G+ L T F VG + TG ++++ Q
Sbjct: 234 EPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTG--------EEVRNPQ 285
Query: 514 KSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSW-PSPWVI 572
K+IPIG + ++L Y + +L +K V V W P+ +V+
Sbjct: 286 KAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYV----GWGPAKYVV 341
Query: 573 VIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAEL 632
GS + + L S+ PR++ A+A+D ++ F + + P A L + A+A L
Sbjct: 342 AAGSLCALSTSLLGSIFPMPRVIYAMAEDGLL-FKCLAQINSKTKTPIIATLSSGAVAAL 400
Query: 633 GILIASLDLVAPILSMFFLMCYLFVNLACAL 663
+ L + ++S+ LM Y V AC L
Sbjct: 401 MAFLFDLKALVDMMSIGTLMAYSLV-AACVL 430
>gi|4507047 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 1 [Homo sapiens]
Length = 629
Score = 40.4 bits (93), Expect = 0.010
Identities = 48/208 (23%), Positives = 89/208 (42%), Gaps = 27/208 (12%)
Query: 477 VLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLS--- 533
VL T F VG + TG ++K+ QK+IP+G + ++L Y
Sbjct: 255 VLSGAATCFYAFVGFDCIATTG--------EEVKNPQKAIPVGIVASLLICFIAYFGVSA 306
Query: 534 --NVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWP-SPWVIVIGSFFSTCGAGLQSLTG 590
+++ C++ DA K + W + + + +GS + + L S+
Sbjct: 307 ALTLMMPYFCLDN---NSPLPDAFK------HVGWEGAKYAVAVGSLCALSASLLGSMFP 357
Query: 591 APRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 650
PR++ A+A+D ++ F + + P A L + A+A + + L + ++S+
Sbjct: 358 MPRVIYAMAEDGLL-FKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGT 416
Query: 651 LMCYLFVNLACALQTLLRTPNWRPRFRY 678
L+ Y V AC L +LR +P Y
Sbjct: 417 LLAYSLV-AACVL--VLRYQPEQPNLVY 441
>gi|9790235 solute carrier family 7, member 10 [Homo sapiens]
Length = 523
Score = 37.4 bits (85), Expect = 0.083
Identities = 39/168 (23%), Positives = 68/168 (40%), Gaps = 6/168 (3%)
Query: 508 DLKDAQKSIPIGTILAILTTSFVY-LSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSW 566
++ DA+K++P ++I +FVY +N+ F A +L G ++G SW
Sbjct: 257 EMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELLSSNAVAVTFGEKLLGYFSW 316
Query: 567 PSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLT 626
P + + +F G L RL + A++ +P L H + + P ALL+
Sbjct: 317 VMPVSVALSTFGGING----YLFTYSRLCFSGAREGHLPSLLAMIHVR-HCTPIPALLVC 371
Query: 627 AAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRP 674
+ +L+ + +S +CY L L R RP
Sbjct: 372 CGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWRRPALHRP 419
>gi|91982772 mucin 17 [Homo sapiens]
Length = 4493
Score = 36.6 bits (83), Expect = 0.14
Identities = 45/203 (22%), Positives = 77/203 (37%), Gaps = 25/203 (12%)
Query: 3 PPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRES------VPETSR 56
P E T + S+ P + LS T D S+ ++ SS + +P ++
Sbjct: 2982 PGERRTPLTSMSVSTMPVASSEASTLSRTPADTSTPVTTSTEASSSPTTAEGTGIPISTP 3041
Query: 57 SEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAY 116
SE + ++ S VA+ S ++ P D NS +++ A
Sbjct: 3042 SEGSTPLTSIPVSTTPVAIPEASTLSTTPVD------SNSPVVTSTEV-SSSPTPAEGTS 3094
Query: 117 LNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANY-----TNLTQGAKEHEEAEN 171
+ S Y EG + L + T P SS ++ ++ T +T + H +
Sbjct: 3095 MPISTYSEG------STPLTGVPVSTTPVTSSAISTLSTTPVDTSTPVTTSTEAHS-SPT 3147
Query: 172 ITEGKKKPTKTPQMGTFMGVYLP 194
+EG PT TP G+ Y+P
Sbjct: 3148 TSEGTSMPTSTPSEGSTPLTYMP 3170
Score = 36.6 bits (83), Expect = 0.14
Identities = 46/195 (23%), Positives = 69/195 (35%), Gaps = 23/195 (11%)
Query: 3 PPETTTKMASVRFMVTPTKIDDIPGLSDTSPD------LSSRSSSRVRFSSRESVPETSR 56
P E T + SV TP + LS T D S+ +SS + S+P ++
Sbjct: 3217 PSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTP 3276
Query: 57 SEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAY 116
SE + ++ S TVA S ++ P D ++ S + D
Sbjct: 3277 SEGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIAD-------GTS 3329
Query: 117 LNNSNYEEGDEYFDKNLALFEEEMDTRPKVSS----LLNRMANYTNLTQGAKEHEEAENI 172
+ S Y EG + L T P VSS L + + + E +
Sbjct: 3330 MPTSTYSEG------STPLTNMSFSTTPVVSSEASTLSTTPVDTSTPVTTSTEASLSPTT 3383
Query: 173 TEGKKKPTKTPQMGT 187
EG PT +P GT
Sbjct: 3384 AEGTSIPTSSPSEGT 3398
Score = 35.4 bits (80), Expect = 0.31
Identities = 51/202 (25%), Positives = 78/202 (38%), Gaps = 37/202 (18%)
Query: 3 PPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLS------SRSSSRVRFSSRESVPETSR 56
P E +T + S+ T + LS T D S S++SS + S+P ++
Sbjct: 3276 PSEGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTY 3335
Query: 57 SE---PMSEMSGATT----SLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGH 109
SE P++ MS +TT S A+ P D TS P + S + T E + +
Sbjct: 3336 SEGSTPLTNMSFSTTPVVSSEASTLSTTPVD-TSTPVTTSTEASLSPTTAEGTSI----- 3389
Query: 110 KKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMA----NYTNLTQGAKE 165
S+ EG L + T P VSS +N ++ + L + E
Sbjct: 3390 --------PTSSPSEG------TTPLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTE 3435
Query: 166 HEEAENITEGKKKPTKTPQMGT 187
+ I EG PT T G+
Sbjct: 3436 ASSSPTIAEGTSLPTSTTSEGS 3457
Score = 34.7 bits (78), Expect = 0.54
Identities = 28/102 (27%), Positives = 45/102 (44%), Gaps = 6/102 (5%)
Query: 3 PPETTTKMASVRFMVTPTKIDDIPGLSDTSPD------LSSRSSSRVRFSSRESVPETSR 56
P E TT +AS+ TP ++ LS T D S+ +SS + S+P ++
Sbjct: 3394 PSEGTTPLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTEASSSPTIAEGTSLPTSTT 3453
Query: 57 SEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSIT 98
SE + +S S VA S ++ P D ++ +S T
Sbjct: 3454 SEGSTPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTSSPT 3495
Score = 32.7 bits (73), Expect = 2.0
Identities = 43/194 (22%), Positives = 71/194 (36%), Gaps = 23/194 (11%)
Query: 3 PPETTTKMASVRFMVTPTKIDDIPGLSDTSPD------LSSRSSSRVRFSSRESVPETSR 56
P E TT + S+ TP + LS T D S+ ++S + S+P ++
Sbjct: 1744 PSEGTTPLTSIPVSTTPVLSSEASTLSATPIDTSTPVTTSTEATSSPTTAEGTSIPTSTL 1803
Query: 57 SEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAY 116
SE M+ ++ S VA S ++ P D S + + S + A
Sbjct: 1804 SEGMTPLTSTPVSHTLVANSEASTLSTTPVD-----SNSPVV--TSTAVSSSPTPAEGTS 1856
Query: 117 LNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGA----KEHEEAENI 172
+ S EG + AL + T SS N ++ +T + +
Sbjct: 1857 IATSTPSEG------STALTSIPVSTTTVASSETNTLSTTPAVTSTPVTTYAQVSSSPTT 1910
Query: 173 TEGKKKPTKTPQMG 186
+G PT TP+ G
Sbjct: 1911 ADGSSMPTSTPREG 1924
Score = 32.3 bits (72), Expect = 2.7
Identities = 48/198 (24%), Positives = 77/198 (38%), Gaps = 29/198 (14%)
Query: 3 PPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSR------ESVPETSR 56
P E + + S+ +TP + LS T D +S ++ SS S+P ++
Sbjct: 801 PSEGSPLLTSIPVSITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTPAEGTSMPTSTY 860
Query: 57 SE---PMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKAR 113
SE P++ M +TT +AT A+ S ++ P D ++ NS S +G
Sbjct: 861 SEGRTPLTSMPVSTTLVATSAI---STLSTTPVDTSTPVT-NSTEARSSPTTSEG----- 911
Query: 114 NAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMA----NYTNLTQGAKEHEEA 169
+ S EG + L T P VSS ++ + + + E +
Sbjct: 912 -TSMPTSTPGEG------STPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSS 964
Query: 170 ENITEGKKKPTKTPQMGT 187
EG PT TP GT
Sbjct: 965 PTTAEGTSIPTSTPSEGT 982
Score = 32.0 bits (71), Expect = 3.5
Identities = 44/193 (22%), Positives = 70/193 (36%), Gaps = 23/193 (11%)
Query: 5 ETTTKMASVRFMVTPTKIDDIPGLSDTSPD------LSSRSSSRVRFSSRESVPETSRSE 58
E TT + S+ T ++ LS T D S+ +SS + S+P ++ SE
Sbjct: 2276 EGTTPLTSIPVSHTLVANSEVSTLSTTPVDSNTPFTTSTEASSPPPTAEGTSMPTSTSSE 2335
Query: 59 PMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLN 118
+ ++ S VA S ++ P D ++ S G DD +
Sbjct: 2336 GNTPLTRMPVSTTMVASFETSTLSTTPADTSTPVTTYSQAGSSPTTADD-------TSMP 2388
Query: 119 NSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMA----NYTNLTQGAKEHEEAENITE 174
S Y EG + L + T P VSS + + + + + E + E
Sbjct: 2389 TSTYSEG------STPLTSVPVSTMPVVSSEASTHSTTPVDTSTPVTTSTEASSSPTTAE 2442
Query: 175 GKKKPTKTPQMGT 187
G PT P GT
Sbjct: 2443 GTSIPTSPPSEGT 2455
Score = 31.2 bits (69), Expect = 5.9
Identities = 32/115 (27%), Positives = 51/115 (44%), Gaps = 14/115 (12%)
Query: 3 PPETTTKMASVRFMVTPTKIDDIPGLSDTSPD------LSSRSSSRVRFSSRESVPETSR 56
P E +T + S+ TP + LS T D S+ +SS + S+P ++
Sbjct: 447 PSEGSTPLTSMPVSTTPVASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTP 506
Query: 57 SE---PMSEMSGAT----TSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQL 104
SE P++ MS +T +S A+ P D TS P + S +S T E + +
Sbjct: 507 SEGSTPLTSMSVSTMPVASSEASTLSTTPVD-TSTPVTTSSEASSSSTTPEGTSI 560
>gi|7662238 apoptotic chromatin condensation inducer 1 [Homo
sapiens]
Length = 1341
Score = 36.2 bits (82), Expect = 0.18
Identities = 42/155 (27%), Positives = 64/155 (41%), Gaps = 12/155 (7%)
Query: 30 DTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDPPSDRTSHPQDVI 89
D P R SSRVR + + E S +P E T + + +DR ++
Sbjct: 218 DEKPRKGERRSSRVRQARAAKLSEGS--QPAEEEEDQETPSRNLRVR--ADRNLKTEEEE 273
Query: 90 EDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSS- 148
E+ + E + D+G +K+R A + EEG+E EE MD RPK S
Sbjct: 274 EEEEEEEEDDEEEEGDDEG-QKSREAPILKEFKEEGEEI---PRVKPEEMMDERPKTRSQ 329
Query: 149 ---LLNRMANYTNLTQGAKEHEEAENITEGKKKPT 180
+L R +T + A++ A E + K T
Sbjct: 330 EQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTT 364
>gi|195927037 DNA (cytosine-5-)-methyltransferase 1 isoform a [Homo
sapiens]
Length = 1632
Score = 36.2 bits (82), Expect = 0.18
Identities = 29/124 (23%), Positives = 47/124 (37%), Gaps = 1/124 (0%)
Query: 990 RTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTW 1049
RT E+R + S+T+ Q +K+ + +DEDE+ + EK H +
Sbjct: 246 RTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQ 305
Query: 1050 TKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMP 1109
KD A R + K E ++ D+ E K AK V+ +
Sbjct: 306 PKD-LAAKRRPEEKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVMNSKT 364
Query: 1110 GPPR 1113
PP+
Sbjct: 365 HPPK 368
>gi|4503351 DNA (cytosine-5-)-methyltransferase 1 isoform b [Homo
sapiens]
Length = 1616
Score = 36.2 bits (82), Expect = 0.18
Identities = 29/124 (23%), Positives = 47/124 (37%), Gaps = 1/124 (0%)
Query: 990 RTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTW 1049
RT E+R + S+T+ Q +K+ + +DEDE+ + EK H +
Sbjct: 230 RTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQ 289
Query: 1050 TKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMP 1109
KD A R + K E ++ D+ E K AK V+ +
Sbjct: 290 PKD-LAAKRRPEEKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVMNSKT 348
Query: 1110 GPPR 1113
PP+
Sbjct: 349 HPPK 352
>gi|181337167 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 14 [Homo sapiens]
Length = 771
Score = 36.2 bits (82), Expect = 0.18
Identities = 43/188 (22%), Positives = 79/188 (42%), Gaps = 14/188 (7%)
Query: 477 VLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVV 536
VL T F +G + TG A K+ SIP +++ Y+S V
Sbjct: 254 VLQGAATCFYAFIGFDIIATTGEEA--------KNPNTSIPYAITASLVICLTAYVSVSV 305
Query: 537 LFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQ 596
+ + + ++ + V + + +V+ IGS + L SL PR++
Sbjct: 306 ILTLMVPYYTIDT---ESPLMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIY 362
Query: 597 AIAKDNIIPFLRVFGHSKANGE-PTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYL 655
A+A D ++ R H + E P A +++ +A L L+ SL + ++S+ L+ Y
Sbjct: 363 AMAGDGLL--FRFLAHVSSYTETPVVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYT 420
Query: 656 FVNLACAL 663
V++ L
Sbjct: 421 LVSVCVLL 428
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,637,579
Number of Sequences: 37866
Number of extensions: 1728664
Number of successful extensions: 5497
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 49
Number of HSP's that attempted gapping in prelim test: 5357
Number of HSP's gapped (non-prelim): 150
length of query: 1150
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1037
effective length of database: 13,968,660
effective search space: 14485500420
effective search space used: 14485500420
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.