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Search of human proteins with 149999378
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
(1240 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens] 2462 0.0
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens] 2446 0.0
gi|14249316 hypothetical protein LOC84800 [Homo sapiens] 455 e-127
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 356 7e-98
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 356 7e-98
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens] 315 2e-85
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens] 315 2e-85
gi|21071077 dishevelled-associated activator of morphogenesis 1 ... 301 3e-81
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens] 299 1e-80
gi|40548415 dishevelled associated activator of morphogenesis 2 ... 286 6e-77
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens] 273 1e-72
gi|33356148 formin-like 1 [Homo sapiens] 256 7e-68
gi|52485606 formin-like 2 [Homo sapiens] 237 5e-62
gi|145309324 FH2 domain containing 1 [Homo sapiens] 233 7e-61
gi|119120861 formin-like 3 isoform 2 [Homo sapiens] 214 3e-55
gi|119120874 formin-like 3 isoform 1 [Homo sapiens] 206 1e-52
gi|160707881 formin 2 [Homo sapiens] 194 3e-49
gi|157168329 formin 1 [Homo sapiens] 168 3e-41
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 155 2e-37
gi|11386183 WAS protein family, member 2 [Homo sapiens] 110 8e-24
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap... 102 2e-21
gi|118572599 formin homology 2 domain containing 1 [Homo sapiens] 100 1e-20
gi|58331242 formin homology 2 domain containing 3 [Homo sapiens] 99 3e-20
gi|153792074 proline rich 12 [Homo sapiens] 98 4e-20
gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens] 91 7e-18
gi|47132519 Ras association and pleckstrin homology domains 1 is... 90 2e-17
gi|210032580 SET domain containing 1B [Homo sapiens] 90 2e-17
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo... 89 3e-17
gi|162329583 cleavage and polyadenylation specific factor 6, 68 ... 87 8e-17
gi|42544130 splicing factor 1 isoform 1 [Homo sapiens] 87 8e-17
>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
Length = 1240
Score = 2462 bits (6382), Expect = 0.0
Identities = 1240/1240 (100%), Positives = 1240/1240 (100%)
Query: 1 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS 60
MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS
Sbjct: 1 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS 60
Query: 61 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS 120
DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS
Sbjct: 61 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS 120
Query: 121 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI 180
NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI
Sbjct: 121 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI 180
Query: 181 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD 240
VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD
Sbjct: 181 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD 240
Query: 241 LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH 300
LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH
Sbjct: 241 LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH 300
Query: 301 LEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKGRPRPSPLVKAHKSV 360
LEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKGRPRPSPLVKAHKSV
Sbjct: 301 LEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKGRPRPSPLVKAHKSV 360
Query: 361 QANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQAST 420
QANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQAST
Sbjct: 361 QANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQAST 420
Query: 421 PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPL 480
PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPL
Sbjct: 421 PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPL 480
Query: 481 PGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVA 540
PGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVA
Sbjct: 481 PGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVA 540
Query: 541 QVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFS 600
QVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFS
Sbjct: 541 QVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFS 600
Query: 601 SIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIR 660
SIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIR
Sbjct: 601 SIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIR 660
Query: 661 AGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIEC 720
AGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIEC
Sbjct: 661 AGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIEC 720
Query: 721 MLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGF 780
MLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGF
Sbjct: 721 MLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGF 780
Query: 781 KISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEA 840
KISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEA
Sbjct: 781 KISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEA 840
Query: 841 SSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCED 900
SSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCED
Sbjct: 841 SSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCED 900
Query: 901 AQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPV 960
AQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPV
Sbjct: 901 AQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPV 960
Query: 961 RKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPA 1020
RKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPA
Sbjct: 961 RKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPA 1020
Query: 1021 GDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYV 1080
GDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYV
Sbjct: 1021 GDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYV 1080
Query: 1081 DASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGV 1140
DASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGV
Sbjct: 1081 DASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGV 1140
Query: 1141 LQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTD 1200
LQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTD
Sbjct: 1141 LQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTD 1200
Query: 1201 SSGSGTLPRARGRASKGTGKRRKKRPSRSQEGLRPRPKAK 1240
SSGSGTLPRARGRASKGTGKRRKKRPSRSQEGLRPRPKAK
Sbjct: 1201 SSGSGTLPRARGRASKGTGKRRKKRPSRSQEGLRPRPKAK 1240
>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
Length = 1249
Score = 2446 bits (6338), Expect = 0.0
Identities = 1232/1235 (99%), Positives = 1233/1235 (99%)
Query: 1 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS 60
MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS
Sbjct: 1 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS 60
Query: 61 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS 120
DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS
Sbjct: 61 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS 120
Query: 121 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI 180
NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI
Sbjct: 121 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI 180
Query: 181 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD 240
VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD
Sbjct: 181 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD 240
Query: 241 LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH 300
LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH
Sbjct: 241 LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH 300
Query: 301 LEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKGRPRPSPLVKAHKSV 360
LEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKGRPRPSPLVKAHKSV
Sbjct: 301 LEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKGRPRPSPLVKAHKSV 360
Query: 361 QANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQAST 420
QANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQAST
Sbjct: 361 QANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQAST 420
Query: 421 PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPL 480
PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPL
Sbjct: 421 PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPL 480
Query: 481 PGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVA 540
PGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVA
Sbjct: 481 PGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVA 540
Query: 541 QVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFS 600
QVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFS
Sbjct: 541 QVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFS 600
Query: 601 SIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIR 660
SIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIR
Sbjct: 601 SIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIR 660
Query: 661 AGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIEC 720
AGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIEC
Sbjct: 661 AGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIEC 720
Query: 721 MLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGF 780
MLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGF
Sbjct: 721 MLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGF 780
Query: 781 KISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEA 840
KISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEA
Sbjct: 781 KISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEA 840
Query: 841 SSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCED 900
SSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCED
Sbjct: 841 SSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCED 900
Query: 901 AQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPV 960
AQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPV
Sbjct: 901 AQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPV 960
Query: 961 RKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPA 1020
RKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPA
Sbjct: 961 RKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPA 1020
Query: 1021 GDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYV 1080
GDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYV
Sbjct: 1021 GDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYV 1080
Query: 1081 DASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGV 1140
DASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGV
Sbjct: 1081 DASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGV 1140
Query: 1141 LQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTD 1200
LQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTD
Sbjct: 1141 LQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTD 1200
Query: 1201 SSGSGTLPRARGRASKGTGKRRKKRPSRSQEGLRP 1235
SSGSGTLPRARGRASKGTGKRRKKRPSRSQE + P
Sbjct: 1201 SSGSGTLPRARGRASKGTGKRRKKRPSRSQEEVPP 1235
>gi|14249316 hypothetical protein LOC84800 [Homo sapiens]
Length = 234
Score = 455 bits (1171), Expect = e-127
Identities = 234/234 (100%), Positives = 234/234 (100%)
Query: 1 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS 60
MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS
Sbjct: 1 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS 60
Query: 61 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS 120
DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS
Sbjct: 61 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS 120
Query: 121 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI 180
NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI
Sbjct: 121 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI 180
Query: 181 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLR 234
VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLR
Sbjct: 181 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLR 234
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 356 bits (914), Expect = 7e-98
Identities = 302/1089 (27%), Positives = 497/1089 (45%), Gaps = 136/1089 (12%)
Query: 36 ELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRG--VARIS 93
EL L MP + LR L + W VQ GL LL+ L RL A
Sbjct: 142 ELRSGLRDMPLLSCLESLRVSLNNNPVSW-VQTFGAEGLASLLDILKRLHDEKEETAGSY 200
Query: 94 DALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIY 153
D+ + + C++A MN++ GI+ +L + + L +A+D + + +LL+ALCI
Sbjct: 201 DSRNKHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCIL 260
Query: 154 -SPEG-HVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDL 211
PE + L+A+ + + RF +++ L + V L +INA+I E+L
Sbjct: 261 PQPEDMNERVLEAMTE-RAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEEL 319
Query: 212 RARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGV--DMS 269
R +R+E + L L VL LR++E+ D+ +QL F+E ED +L + +M
Sbjct: 320 DFRVHIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMD 379
Query: 270 SHQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDA 329
EVF L + V S LS+LQ LL + + ++ +E +++ VL + A
Sbjct: 380 DFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGA 439
Query: 330 Q------------ECTLEEVVERLLSVKGRPRPSPLVK--------------AHKSVQAN 363
E +++++++ K + + L K K ++++
Sbjct: 440 DPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESD 499
Query: 364 LDQSQRG---------SSPQNTTTPKPSVEGQ----QPAAAAACEPVDHAQSE----SIL 406
+Q + S Q T K +E + A + ++ A+ E S
Sbjct: 500 FEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAA 559
Query: 407 KVSQPRALEQQASTPPPPP---------PPPLLPGSSAEPPPPPPPPP------------ 445
++ P ++ +A PP PP PPP PG S PPPPPPPPP
Sbjct: 560 AITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCIS 619
Query: 446 ----LPSVGAKALP-------TAPPPPPLP---GL--------GAMAPPAPPL------- 476
LP A + P T PPPPPLP G+ G PP PPL
Sbjct: 620 SPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIP 679
Query: 477 --PPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGM 534
PPPLPGS +PPPPPPLPG PPPPP LPG PPPPP P P PP GM
Sbjct: 680 PPPPPLPGSAG-IPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGM 738
Query: 535 EEVIVAQVDHGLGSAWVP------SHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLS 588
G G P + +++ P +++++ NW KL + + + W +
Sbjct: 739 P----PPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQ-DCFWTKVK 793
Query: 589 SPDAEAVEPDFSSIERLFS--FPAAKPKEPTMVAPR----ARKEPKEITFLDAKKSLNLN 642
E E F+ + FS +K K+ +K+ KE+ LD+K + NL+
Sbjct: 794 EDRFENNEL-FAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLS 852
Query: 643 IFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASAD 702
IFL F+ +E+ +I + +++ L+K +PE +++ L +E LA ++
Sbjct: 853 IFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESE 912
Query: 703 HFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLIL 762
F +++ +P + R+ +L + ++ ++P+ V AACE L S ++ L
Sbjct: 913 QFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITL 972
Query: 763 RIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDL 822
+GN++N GS A GF IS L KL +TKS ++TLLH + E E +PD+L+ P +L
Sbjct: 973 LVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDEL 1032
Query: 823 EQPSQAAGINLEIIRSEASSNLKKLLETERKVS--ASVAEVQEQYTERLQASI----SAF 876
+A+ ++ E ++ K++ + ER V + + ++++ E++ + + +
Sbjct: 1033 AHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQY 1092
Query: 877 RALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAK 936
L + +E +EL +Y D ++LS+E+ F + FR++FL+A+KEN+ R+E K
Sbjct: 1093 NKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEK 1152
Query: 937 AERRKQQLAEEEARRPRGEDGKPVRK---GPGKQEEVCVIDALLADIRKGFQLRKTARGR 993
R K LA+E+A + R E + + + +E V+D+LL ++ G R R R
Sbjct: 1153 MRRAK--LAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFR---RKR 1207
Query: 994 GDTDGGSKA 1002
G KA
Sbjct: 1208 GPRQANRKA 1216
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 356 bits (914), Expect = 7e-98
Identities = 302/1089 (27%), Positives = 497/1089 (45%), Gaps = 136/1089 (12%)
Query: 36 ELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRG--VARIS 93
EL L MP + LR L + W VQ GL LL+ L RL A
Sbjct: 151 ELRSGLRDMPLLSCLESLRVSLNNNPVSW-VQTFGAEGLASLLDILKRLHDEKEETAGSY 209
Query: 94 DALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIY 153
D+ + + C++A MN++ GI+ +L + + L +A+D + + +LL+ALCI
Sbjct: 210 DSRNKHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCIL 269
Query: 154 -SPEG-HVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDL 211
PE + L+A+ + + RF +++ L + V L +INA+I E+L
Sbjct: 270 PQPEDMNERVLEAMTE-RAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEEL 328
Query: 212 RARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGV--DMS 269
R +R+E + L L VL LR++E+ D+ +QL F+E ED +L + +M
Sbjct: 329 DFRVHIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMD 388
Query: 270 SHQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDA 329
EVF L + V S LS+LQ LL + + ++ +E +++ VL + A
Sbjct: 389 DFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGA 448
Query: 330 Q------------ECTLEEVVERLLSVKGRPRPSPLVK--------------AHKSVQAN 363
E +++++++ K + + L K K ++++
Sbjct: 449 DPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESD 508
Query: 364 LDQSQRG---------SSPQNTTTPKPSVEGQ----QPAAAAACEPVDHAQSE----SIL 406
+Q + S Q T K +E + A + ++ A+ E S
Sbjct: 509 FEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAA 568
Query: 407 KVSQPRALEQQASTPPPPP---------PPPLLPGSSAEPPPPPPPPP------------ 445
++ P ++ +A PP PP PPP PG S PPPPPPPPP
Sbjct: 569 AITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCIS 628
Query: 446 ----LPSVGAKALP-------TAPPPPPLP---GL--------GAMAPPAPPL------- 476
LP A + P T PPPPPLP G+ G PP PPL
Sbjct: 629 SPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIP 688
Query: 477 --PPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGM 534
PPPLPGS +PPPPPPLPG PPPPP LPG PPPPP P P PP GM
Sbjct: 689 PPPPPLPGSAG-IPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGM 747
Query: 535 EEVIVAQVDHGLGSAWVP------SHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLS 588
G G P + +++ P +++++ NW KL + + + W +
Sbjct: 748 P----PPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQ-DCFWTKVK 802
Query: 589 SPDAEAVEPDFSSIERLFS--FPAAKPKEPTMVAPR----ARKEPKEITFLDAKKSLNLN 642
E E F+ + FS +K K+ +K+ KE+ LD+K + NL+
Sbjct: 803 EDRFENNEL-FAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLS 861
Query: 643 IFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASAD 702
IFL F+ +E+ +I + +++ L+K +PE +++ L +E LA ++
Sbjct: 862 IFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESE 921
Query: 703 HFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLIL 762
F +++ +P + R+ +L + ++ ++P+ V AACE L S ++ L
Sbjct: 922 QFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITL 981
Query: 763 RIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDL 822
+GN++N GS A GF IS L KL +TKS ++TLLH + E E +PD+L+ P +L
Sbjct: 982 LVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDEL 1041
Query: 823 EQPSQAAGINLEIIRSEASSNLKKLLETERKVS--ASVAEVQEQYTERLQASI----SAF 876
+A+ ++ E ++ K++ + ER V + + ++++ E++ + + +
Sbjct: 1042 AHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQY 1101
Query: 877 RALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAK 936
L + +E +EL +Y D ++LS+E+ F + FR++FL+A+KEN+ R+E K
Sbjct: 1102 NKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEK 1161
Query: 937 AERRKQQLAEEEARRPRGEDGKPVRK---GPGKQEEVCVIDALLADIRKGFQLRKTARGR 993
R K LA+E+A + R E + + + +E V+D+LL ++ G R R R
Sbjct: 1162 MRRAK--LAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFR---RKR 1216
Query: 994 GDTDGGSKA 1002
G KA
Sbjct: 1217 GPRQANRKA 1225
>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
Length = 1096
Score = 315 bits (807), Expect = 2e-85
Identities = 259/965 (26%), Positives = 447/965 (46%), Gaps = 110/965 (11%)
Query: 53 LRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSR 112
LR L + W+ F + GL LLL+ L +L + D Q + C++A MN++
Sbjct: 186 LRVSLTSNPVSWVNNFGHE-GLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAFMNNK 244
Query: 113 QGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVC 172
G++ IL ++ + L++A+D + ++ ++L+A+CI E LD L T
Sbjct: 245 FGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEEN---ILDKLLGAITTA 301
Query: 173 SQQY---RFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDV 229
+++ RFS ++ L + + V + INA++ P +L R LRNEF+ L +
Sbjct: 302 AERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTM 361
Query: 230 LARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGV--DMSSHQEVFASLFHKVSCSPV 287
L L++ E+ +L IQL+ F+E K +D EL + +M EV+ L++ + +
Sbjct: 362 LPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAA 421
Query: 288 SAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ---------ECTLEEVV 338
LS+LQ L + ++ +E V++ VL S + L ++
Sbjct: 422 ENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLI 481
Query: 339 ERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVD 398
+ ++ +A +++S++ ++ + + Q+ A A + D
Sbjct: 482 DSCVN-----------------KAKVEESEQKAAEFSKKFDEEFTARQE--AQAELQKRD 522
Query: 399 HAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAP 458
E ++ Q R Q S SS+ P PP PPLP VG
Sbjct: 523 EKIKELEAEIQQLRTQAQVLS-------------SSSGIPGPPAAPPLPGVG-------- 561
Query: 459 PPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGL-GCPPPPPPLLPGMGWGPPPP 517
PPPP PPAPPLP P LPPPPPPLPG+ G PPPPPP L +G PPP
Sbjct: 562 PPPP--------PPAPPLPGGAP-----LPPPPPPLPGMMGIPPPPPPPLL---FGGPPP 605
Query: 518 PPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVA 577
PPPL PP G I + +G+ +++ P + MK++NW K+
Sbjct: 606 PPPL---GGVPPPPG-----ISLNLPYGM------KQKKMYKPEVSMKRINWSKIEPTEL 651
Query: 578 REHNSMWASLSSPDAEAVEPD-FSSIERLFSFPAAKPKEPTMVAPR----ARKEPKEITF 632
E N W + E PD F+ + F+ K + + +K+ KE+
Sbjct: 652 SE-NCFWLRVKEDKFE--NPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRI 708
Query: 633 LDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFT 692
LD K + NL+IFL ++ E++ +I + +++ L+K LPE+ + L
Sbjct: 709 LDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELK 768
Query: 693 EERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSR 752
E L + F +++ ++ Q R+ +L ++ ++P V ACE L S
Sbjct: 769 NEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSE 828
Query: 753 QLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSH 812
+L+L +GN++N GS + GFKI+ L K+ +TKS + TLLH + + E+ +
Sbjct: 829 SFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKY 888
Query: 813 PDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQAS 872
D+L+ P +LE A+ ++ +I++S +S ++++ ER + + + Q+ + ++
Sbjct: 889 RDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIK-KFPQAENQHDKFVEKM 947
Query: 873 ISAFRALDELFEAIE-------QKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALK 925
S + E +E + + L +Y D++ +S+E+ F + FR LFL A++
Sbjct: 948 TSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVR 1007
Query: 926 ENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRK--GPGKQ-EEVCVIDALLADIRK 982
EN R+E K R K LA+E+A + + E K ++ K+ +E V+D LL ++
Sbjct: 1008 ENNKRREMEEKTRRAK--LAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQS 1065
Query: 983 GFQLR 987
G R
Sbjct: 1066 GAAFR 1070
>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
Length = 1101
Score = 315 bits (807), Expect = 2e-85
Identities = 259/965 (26%), Positives = 447/965 (46%), Gaps = 110/965 (11%)
Query: 53 LRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSR 112
LR L + W+ F + GL LLL+ L +L + D Q + C++A MN++
Sbjct: 186 LRVSLTSNPVSWVNNFGHE-GLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAFMNNK 244
Query: 113 QGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVC 172
G++ IL ++ + L++A+D + ++ ++L+A+CI E LD L T
Sbjct: 245 FGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEEN---ILDKLLGAITTA 301
Query: 173 SQQY---RFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDV 229
+++ RFS ++ L + + V + INA++ P +L R LRNEF+ L +
Sbjct: 302 AERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTM 361
Query: 230 LARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGV--DMSSHQEVFASLFHKVSCSPV 287
L L++ E+ +L IQL+ F+E K +D EL + +M EV+ L++ + +
Sbjct: 362 LPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAA 421
Query: 288 SAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ---------ECTLEEVV 338
LS+LQ L + ++ +E V++ VL S + L ++
Sbjct: 422 ENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLI 481
Query: 339 ERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVD 398
+ ++ +A +++S++ ++ + + Q+ A A + D
Sbjct: 482 DSCVN-----------------KAKVEESEQKAAEFSKKFDEEFTARQE--AQAELQKRD 522
Query: 399 HAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAP 458
E ++ Q R Q S SS+ P PP PPLP VG
Sbjct: 523 EKIKELEAEIQQLRTQAQVLS-------------SSSGIPGPPAAPPLPGVG-------- 561
Query: 459 PPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGL-GCPPPPPPLLPGMGWGPPPP 517
PPPP PPAPPLP P LPPPPPPLPG+ G PPPPPP L +G PPP
Sbjct: 562 PPPP--------PPAPPLPGGAP-----LPPPPPPLPGMMGIPPPPPPPLL---FGGPPP 605
Query: 518 PPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVA 577
PPPL PP G I + +G+ +++ P + MK++NW K+
Sbjct: 606 PPPL---GGVPPPPG-----ISLNLPYGM------KQKKMYKPEVSMKRINWSKIEPTEL 651
Query: 578 REHNSMWASLSSPDAEAVEPD-FSSIERLFSFPAAKPKEPTMVAPR----ARKEPKEITF 632
E N W + E PD F+ + F+ K + + +K+ KE+
Sbjct: 652 SE-NCFWLRVKEDKFE--NPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRI 708
Query: 633 LDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFT 692
LD K + NL+IFL ++ E++ +I + +++ L+K LPE+ + L
Sbjct: 709 LDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELK 768
Query: 693 EERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSR 752
E L + F +++ ++ Q R+ +L ++ ++P V ACE L S
Sbjct: 769 NEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSE 828
Query: 753 QLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSH 812
+L+L +GN++N GS + GFKI+ L K+ +TKS + TLLH + + E+ +
Sbjct: 829 SFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKY 888
Query: 813 PDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQAS 872
D+L+ P +LE A+ ++ +I++S +S ++++ ER + + + Q+ + ++
Sbjct: 889 RDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIK-KFPQAENQHDKFVEKM 947
Query: 873 ISAFRALDELFEAIE-------QKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALK 925
S + E +E + + L +Y D++ +S+E+ F + FR LFL A++
Sbjct: 948 TSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVR 1007
Query: 926 ENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRK--GPGKQ-EEVCVIDALLADIRK 982
EN R+E K R K LA+E+A + + E K ++ K+ +E V+D LL ++
Sbjct: 1008 ENNKRREMEEKTRRAK--LAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQS 1065
Query: 983 GFQLR 987
G R
Sbjct: 1066 GAAFR 1070
>gi|21071077 dishevelled-associated activator of morphogenesis 1 [Homo
sapiens]
Length = 1078
Score = 301 bits (771), Expect = 3e-81
Identities = 254/966 (26%), Positives = 440/966 (45%), Gaps = 116/966 (12%)
Query: 64 WMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQG 123
++ +F++ GL +L L + S++ + + + C++A+MN+ QG ++L++
Sbjct: 148 FVTRFIDLDGLSCILNFLKTMD----YETSESRIHTSLIGCIKALMNNSQGRAHVLAHSE 203
Query: 124 YVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMN 183
+ ++Q+L T N+ K V E+L A+C+ P GH L A+ HY+ S++ RF ++N
Sbjct: 204 SINVIAQSLSTENIKTKVAVLEILGAVCLV-PGGHKKVLQAMLHYQKYASERTRFQTLIN 262
Query: 184 ELSGS-----DNVPYVVTLLSVINAVI---LGPEDLRARTQLRNEFIGLQLLDVLARLRD 235
+L S D V ++S INAV+ G E L R LR EF+ L + V+ +LR+
Sbjct: 263 DLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLRE 322
Query: 236 LEDADLLIQLEAFEEAKAEDEEELLRVSG--GVDMSSHQEVFASLFHKVSCSPVSAQLLS 293
E++ L L+ FE + EDE E + +D S ++F +++ S +S
Sbjct: 323 HENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFMS 382
Query: 294 VLQGLLHLEPTLRSSQLL--WEALESLVNRAVLLASDAQE--------CTLEEVVERLLS 343
+L L + P RS + W L+ ++ + V+ Q+ ++ VV L++
Sbjct: 383 ILHHCLQM-PYKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTPLENFNIKNVVRMLVN 441
Query: 344 V----KGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDH 399
+ + + + K H +Q L++ +R + + + E +H
Sbjct: 442 ENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEH 501
Query: 400 AQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPP 459
Q + Q L Q L + +A+ + P
Sbjct: 502 KQVKQ-----QVADLTAQ----------------------------LHELSRRAVCASIP 528
Query: 460 PPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPP- 518
P PG P P P +PGS PPPPPPLPG PPPPPPL PG GPPPPP
Sbjct: 529 GGPSPGA-----PGGPFPSSVPGSL-LPPPPPPPLPGGMLPPPPPPLPPG---GPPPPPG 579
Query: 519 PPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAR 578
PP L PP G + + PT +K NW KLP N +
Sbjct: 580 PPPLGAIMPPP---------------GAPMGLALKKKSIPQPTNALKSFNWSKLPEN--K 622
Query: 579 EHNSMWASLSSP------DAEAVEPDFSSIERLFSF---PAAKPKEPTMVAPR--ARKEP 627
++W + D E +E FS+ +R F +K KE + ++ +
Sbjct: 623 LEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFFVNSNSKQKEADAIDDTLSSKLKV 682
Query: 628 KEITFLDAKKSLNLNIFLKQFKCSNEEVA-AMIRAGDTTKFDVEVLKQLLKLLPEKHEIE 686
KE++ +D +++ N NI L + K SN+E+ A++ + ++L+QLLK +PEK +I+
Sbjct: 683 KELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDID 742
Query: 687 NLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACE 746
L E ++A AD F + I YQ R++ + + A + V+PK + + + E
Sbjct: 743 LLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSE 802
Query: 747 SLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQ-QNRVTLLHHVL 805
+ S L +++L GN++N G G+A GFKIS+L K+ +TKS +TLLH+++
Sbjct: 803 EVFRSGALKQLLEVVLAFGNYMNKGQR-GNAYGFKISSLNKIADTKSSIDKNITLLHYLI 861
Query: 806 EEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASS--NLKKLLETERKVSASVA---- 859
E +P +L L +L QAA +N+ + E S+ + K +ETE + S
Sbjct: 862 TIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKSQPPQPG 921
Query: 860 -EVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRD 918
+ ++ + + +F +++L + + + E+A ++ ++ F D
Sbjct: 922 DKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGIF----D 977
Query: 919 LFLRALKENKDRKEQAAKAERRKQQLAEEEAR-RPRGEDGKPVRKGPGKQEEVCVIDALL 977
FL+A+ E K E K + +++ A EA+ + + E + +RK EE D L+
Sbjct: 978 QFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQRERERKMRKAKENSEESGEFDDLV 1037
Query: 978 ADIRKG 983
+ +R G
Sbjct: 1038 SALRSG 1043
>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
Length = 1193
Score = 299 bits (766), Expect = 1e-80
Identities = 253/978 (25%), Positives = 451/978 (46%), Gaps = 102/978 (10%)
Query: 35 PELCIRLLQMPS-----VVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGV 89
P+ I L+M S V LR L + W+ F + GL LLL+ L +L +
Sbjct: 176 PQEFIHELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHE-GLGLLLDILEKLISGKI 234
Query: 90 ARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAA 149
Q + C++A+MN++ G+E I+S + + L++A+D + + V +LL+A
Sbjct: 235 QEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSA 294
Query: 150 LCIYSPEGHVLTLDALDHYKTVCSQQY--RFSIVMNELSGSDNVPYVVTLLSVINAVILG 207
+CI E + + L+ + ++ RF ++ L ++V V + +INA++
Sbjct: 295 VCIVGEES--ILEEVLEALTSAGEEKKIDRFFCIVEGLR-HNSVQLQVACMQLINALVTS 351
Query: 208 PEDLRARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGV- 266
P+DL R +RNEF+ L ++L L+ +++ L IQL+ F+E K ED EL +
Sbjct: 352 PDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIR 411
Query: 267 -DMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLL 325
++ +V+ ++ V + +S+LQ LL + Q ++ ++ V++ VL
Sbjct: 412 AELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLH 471
Query: 326 ASDAQ-ECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVE 384
+ T + ++ L+ + V +DQ++ + + E
Sbjct: 472 RDGMDPDFTYRKRLDLDLT--------------QFVDICIDQAKLEEFEEKASELYKKFE 517
Query: 385 GQQPAAAAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPP 444
E DH ++++ L+ + + E QA LP A+ P PP
Sbjct: 518 K---------EFTDHQETQAELQKKEAKINELQAELQAFKSQFGALP---ADCNIPLPPS 565
Query: 445 PLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCP---- 500
G ALP PPPPLP G + PP PP PPPPPLPG+ P
Sbjct: 566 KEGGTGHSALP---PPPPLPSGGGVPPPPPP-------------PPPPPLPGMRMPFSGP 609
Query: 501 -PPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNP 559
PPPPPL G G PP P+LP P ++
Sbjct: 610 VPPPPPL--GFLGGQNSPPLPILPFGLKP--------------------------KKEFK 641
Query: 560 PTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEPTMV 619
P + M++LNW K+ + E N W ++ E V+ +E F + +E +
Sbjct: 642 PEISMRRLNWLKIRPHEMTE-NCFWIKVNENKYENVDL-LCKLENTFCCQQKERREEEDI 699
Query: 620 APRA--RKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLK 677
+ +K+ KE+ FLD+K + NL+IFL F+ EE+ MI D T+ +++ L+K
Sbjct: 700 EEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIK 759
Query: 678 LLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPK 737
LP++ ++ +L F E + L + F +++ + + R+ +L ++ ++P
Sbjct: 760 HLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPD 819
Query: 738 AQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNR 797
V ACE + S+ +L+L +GN++N GS GF +S+L KL +TKS +
Sbjct: 820 IMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQK 879
Query: 798 VTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKL--LETERKVS 855
TLLH ++E E+ +PD+L DLE +A+ +++E + ++L LE E +
Sbjct: 880 TTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETF 939
Query: 856 ASVAEVQEQYTERLQASI----SAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFS 911
++ +++ ++ + + L +L E +E+ + + Y D +++S+ED +
Sbjct: 940 PPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLT 999
Query: 912 TMKAFRDLFLRALKENKDRKEQAAKAERRK--QQLAEEEARRPRGEDGKPVRKGPGKQEE 969
+ FR F++A+KEN ++E K +R + ++LAE E R R + K + + + +E
Sbjct: 1000 DLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERE-RLERQQKKKRLLEMKTEGDE 1058
Query: 970 VCVIDALLADIRKGFQLR 987
V+D LL ++ G R
Sbjct: 1059 TGVMDNLLEALQSGAAFR 1076
>gi|40548415 dishevelled associated activator of morphogenesis 2 [Homo
sapiens]
Length = 1067
Score = 286 bits (733), Expect = 6e-77
Identities = 262/993 (26%), Positives = 444/993 (44%), Gaps = 121/993 (12%)
Query: 64 WMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQG 123
++ +F+E GL LL L + ++ + + + C++A+MN+ QG ++L+
Sbjct: 144 FVTRFIELEGLTCLLNFLRSMDHA----TCESRIHTSLIGCIKALMNNSQGRAHVLAQPE 199
Query: 124 YVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMN 183
+ ++Q+L T N K V E+L A+C+ P GH L A+ HY+ +++ RF ++N
Sbjct: 200 AISTIAQSLRTENSKTKVAVLEILGAVCLV-PGGHKKVLQAMLHYQVYAAERTRFQTLLN 258
Query: 184 ELSGS-----DNVPYVVTLLSVINAVI---LGPEDLRARTQLRNEFIGLQLLDVLARLRD 235
EL S D V ++S INAV+ G ++L R LR EF+ L + V+ +LR
Sbjct: 259 ELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQ 318
Query: 236 LEDADLLIQLEAFEEAKAEDEEELLRVSGGV--DMSSHQEVFASLFHKVSCSPVSAQLLS 293
E+A L L+ FE + ED+ EL R V D S ++F + K+ + LLS
Sbjct: 319 HENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKYTEAYPCLLS 378
Query: 294 VLQGLLHLEPTLRSSQLL--WEALESLVNRAVLL--------ASDAQECTLEEVVERLLS 343
VL L + P R+ W+ L+ ++ + VL + + ++ +V L++
Sbjct: 379 VLHHCLQM-PYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDLAPLENFNVKNIVNMLIN 437
Query: 344 V----KGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKP--SVEGQQPAAAAACEPV 397
+ R + K H + + L++ +R + + ++ + A + +
Sbjct: 438 ENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQEL 497
Query: 398 DHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTA 457
A+ + V+Q L + PPPP PL SS + T
Sbjct: 498 RQARGQVAELVAQLSELSTGPVSSPPPPGGPLTLSSS-------------------MTTN 538
Query: 458 PPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPP 517
PPP PPPLP +C PPPPPPLP G PP PP P +G G P P
Sbjct: 539 DLPPP--------------PPPLPFAC-CPPPPPPPLPP-GGPPTPPGAPPCLGMGLPLP 582
Query: 518 PPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVP-SHRRVNPPTLRMKKLNWQKLPSNV 576
P S+ VP +RV P+ +K NW KL N
Sbjct: 583 QDP-------------------------YPSSDVPLRKKRVPQPSHPLKSFNWVKL--NE 615
Query: 577 AREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKE--PTMVAPRARKEPKEITFLD 634
R ++W + + D E++FS KE T A ++ KE++ +D
Sbjct: 616 ERVPGTVWNEIDDMQVFRI-LDLEDFEKMFSAYQRHQKELGSTEDIYLASRKVKELSVID 674
Query: 635 AKKSLNLNIFLKQFKCSNEEV-AAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTE 693
+++ N I L + K SNEE+ A+++ + ++L+QLLK +PEK +I+ L
Sbjct: 675 GRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKH 734
Query: 694 ERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQ 753
E ++A AD F + I YQ R++ + + L +PK + +L A L+ S++
Sbjct: 735 EIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKR 794
Query: 754 LPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNR-VTLLHHVLEEAEKSH 812
L ++IL IGNF+N G G A GF++++L K+ +TKS +R ++LLH+++ EK
Sbjct: 795 LRQMLEVILAIGNFMNKGQR-GGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHF 853
Query: 813 PDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQ-------Y 865
PD+L +P +L+ +AA +NL + E NL++ L + +V+E
Sbjct: 854 PDILNMPSELQHLPEAAKVNLAELEKEV-GNLRRGLRAVEVLEYQRRQVREPSDKFVPVM 912
Query: 866 TERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLF----- 920
++ + S +F L++ K + + E ++ ++ F F F
Sbjct: 913 SDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQ 972
Query: 921 -LRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLAD 979
L A++ K+ +E+ A R + + +E+ R R + + V EE D L++
Sbjct: 973 DLEAMRRRKEEEERRA----RMEAMLKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSA 1028
Query: 980 IRKG--FQLRKTARGRGDTDGGSKAASMDPPRA 1010
+R G F R GS+A + RA
Sbjct: 1029 LRSGEVFDKDLCKLKRSRKRSGSQALEVTRERA 1061
>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
Length = 849
Score = 273 bits (697), Expect = 1e-72
Identities = 227/889 (25%), Positives = 410/889 (46%), Gaps = 96/889 (10%)
Query: 119 LSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQY-- 176
+S + + L++A+D + + V +LL+A+CI E + + L+ + ++
Sbjct: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEES--ILEEVLEALTSAGEEKKID 58
Query: 177 RFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDL 236
RF ++ L ++V V + +INA++ P+DL R +RNEF+ L ++L L+ +
Sbjct: 59 RFFCIVEGLR-HNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCI 117
Query: 237 EDADLLIQLEAFEEAKAEDEEELLRVSGGV--DMSSHQEVFASLFHKVSCSPVSAQLLSV 294
++ L IQL+ F+E K ED EL + ++ +V+ ++ V + +S+
Sbjct: 118 KNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISI 177
Query: 295 LQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ-ECTLEEVVERLLSVKGRPRPSPL 353
LQ LL + Q ++ ++ V++ VL + T + ++ L+
Sbjct: 178 LQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLT---------- 227
Query: 354 VKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRA 413
+ V +DQ++ + + E E DH ++++ L+ + +
Sbjct: 228 ----QFVDICIDQAKLEEFEEKASELYKKFEK---------EFTDHQETQAELQKKEAKI 274
Query: 414 LEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPA 473
E QA LP A+ P PP G ALP PPPPLP G + PP
Sbjct: 275 NELQAELQAFKSQFGALP---ADCNIPLPPSKEGGTGHSALP---PPPPLPSGGGVPPPP 328
Query: 474 PPLPPPLPGSCEFLPPPPPPLPGLGCP-----PPPPPLLPGMGWGPPPPPPPLLPCTCSP 528
PP PPPPPLPG+ P PPPPPL G G PP P+LP P
Sbjct: 329 PP-------------PPPPPLPGMRMPFSGPVPPPPPL--GFLGGQNSPPLPILPFGLKP 373
Query: 529 PVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLS 588
++ P + M++LNW K+ + E N W ++
Sbjct: 374 --------------------------KKEFKPEISMRRLNWLKIRPHEMTE-NCFWIKVN 406
Query: 589 SPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRA--RKEPKEITFLDAKKSLNLNIFLK 646
E V+ +E F + +E + + +K+ KE+ FLD+K + NL+IFL
Sbjct: 407 ENKYENVDL-LCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLS 465
Query: 647 QFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYL 706
F+ EE+ MI D T+ +++ L+K LP++ ++ +L F E + L + F +
Sbjct: 466 SFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVV 525
Query: 707 LLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGN 766
++ + + R+ +L ++ ++P V ACE + S+ +L+L +GN
Sbjct: 526 VMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGN 585
Query: 767 FLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPS 826
++N GS GF +S+L KL +TKS + TLLH ++E E+ +PD+L DLE
Sbjct: 586 YMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLD 645
Query: 827 QAAGINLEIIRSEASSNLKKL--LETERKVSASVAEVQEQYTERLQASI----SAFRALD 880
+A+ +++E + ++L LE E + ++ +++ ++ + + L
Sbjct: 646 KASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLS 705
Query: 881 ELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERR 940
+L E +E+ + + Y D +++S+ED + + FR F++A+KEN ++E K +R
Sbjct: 706 KLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRV 765
Query: 941 K--QQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLR 987
+ ++LAE E R R + K + + + +E V+D LL ++ G R
Sbjct: 766 RIAKELAERE-RLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFR 813
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 256 bits (655), Expect = 7e-68
Identities = 244/898 (27%), Positives = 387/898 (43%), Gaps = 125/898 (13%)
Query: 101 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVL 160
C+ C+RA+MN + G ++++ V +++ +L+ N K V ELLAA+C+ GH +
Sbjct: 230 CIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRG-GHDI 288
Query: 161 TLDALDHYKTVCSQQYRFSIVMNELSGSD-NVPYVVTLLSVINAVILGPEDLRARTQLRN 219
L A D++K VC +Q+RF +M D N+ ++V + IN V+ E++ R L+
Sbjct: 289 ILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQY 348
Query: 220 EFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLF 279
EF L L L RLR E L +Q++A+ + D LL D + V
Sbjct: 349 EFTHLGLDLYLERLRLTESDKLQVQIQAYLD-NIFDVGALLE-----DTETKNAV----- 397
Query: 280 HKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVE 339
L H+E LL E L N ++ ++ ++ L + +
Sbjct: 398 ------------------LEHMEELQEQVALLTERLRDAENESMAKIAELEK-QLSQARK 438
Query: 340 RLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPS---------VEGQQPAA 390
L +++ R S + A S+R P+ P+ E ++
Sbjct: 439 ELETLRERFSESTAMGA----------SRRPPEPEKAPPAAPTRPSALELKVEELEEKGL 488
Query: 391 AAACEPVDHAQSESILKVSQPRALEQQASTPPPP---PPPPLLPGSSAEPPP---PPPPP 444
A S IL V+ A TP P P P L P +AEP P PPPPP
Sbjct: 489 IRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAP--AAEPAPGAAPPPPP 546
Query: 445 PLPSVGA--KALPTAPPP-PPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPP 501
PLP + + +A P+APP PPLPG P PP PPLPG PPPPPP PG P
Sbjct: 547 PLPGLPSPQEAPPSAPPQAPPLPG-----SPEPPPAPPLPGDLPPPPPPPPPPPGTDGPV 601
Query: 502 PPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNP-- 559
PPPP PPPPPPP PP A G D LG P + P
Sbjct: 602 PPPP--------PPPPPPP-----GGPPDALGRR-------DSELG----PGVKAKKPIQ 637
Query: 560 PTLRMKKLNWQKL-PSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPK--EP 616
RM LNW L PS + +++ L+ + E D S E F + P
Sbjct: 638 TKFRMPLLNWVALKPSQIT---GTVFTELND-EKVLQELDMSDFEEQFKTKSQGPSLDLS 693
Query: 617 TMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLL 676
+ + A+K P + T ++A ++ NL I L++ E + I A D ++ L+ L+
Sbjct: 694 ALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLM 753
Query: 677 KLLPEKHEIENLRAFTEER---AKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDM 733
+ LP ++E + F E+ +L+ D F L IP R+ + +
Sbjct: 754 RFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQL 813
Query: 734 VRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKS 793
+ P+ ++AA S+ +S +L +++L GN++N S G A GF++ +L L E KS
Sbjct: 814 LMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMN-SSKRGAAYGFRLQSLDALLEMKS 872
Query: 794 QQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERK 853
+ TLLH++++ + +P L DL +A ++L+ + ++ S + L T+R+
Sbjct: 873 TDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQRE 932
Query: 854 VSAS-----VAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLED 908
+ E + + ++ + E FE++ +Y E+ + S
Sbjct: 933 FVRQDDCMVLKEFLRANSPTMDKLLADSKTAQEAFESV-------VEYFGENPKTTSPGL 985
Query: 909 TFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGK 966
FS F + +A +E + K++AA A+E G+ P K P K
Sbjct: 986 FFSLFSRFIKAYKKAEQEVEQWKKEAA---------AQEAGADTPGKGEPPAPKSPPK 1034
Score = 35.0 bits (79), Expect = 0.44
Identities = 51/242 (21%), Positives = 95/242 (39%), Gaps = 28/242 (11%)
Query: 866 TERLQASISAFRALDELFEA-IEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRAL 924
+++LQ I A+ LD +F+ + E + + E ++L + T + RD ++
Sbjct: 367 SDKLQVQIQAY--LDNIFDVGALLEDTETKNAVLEHMEELQEQVALLTER-LRDAENESM 423
Query: 925 KENKDRKEQAAKAERR----KQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADI 980
+ + ++Q ++A + +++ +E A +P + P ++ + ++
Sbjct: 424 AKIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEEL 483
Query: 981 RKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATT 1040
+ +R RG GD A S++ PVA + P+G + P P D
Sbjct: 484 EEKGLIR-ILRGPGD------AVSIE----ILPVAVATPSGGDAPTPGVPTGSPSPDLAP 532
Query: 1041 ASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGA 1100
A+E P P P L G P P E S A + + +P PL G
Sbjct: 533 AAEP-----APGAAPPPPPPL----PGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGD 583
Query: 1101 WP 1102
P
Sbjct: 584 LP 585
>gi|52485606 formin-like 2 [Homo sapiens]
Length = 1092
Score = 237 bits (605), Expect = 5e-62
Identities = 221/896 (24%), Positives = 386/896 (43%), Gaps = 99/896 (11%)
Query: 101 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVL 160
C+ C+RA+MN + G ++S+ V +++ +L+ N K V ELLAA+C+ GH +
Sbjct: 224 CIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRG-GHEI 282
Query: 161 TLDALDHYKTVCSQQYRFSIVMNELSGSDN-VPYVVTLLSVINAVILGPEDLRARTQLRN 219
L A D++K VC ++ RF +M DN + ++V + IN V+ ED+ R L+
Sbjct: 283 ILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQY 342
Query: 220 EFIGLQLLDVLARLRDLEDADLLIQLEAFEE------AKAEDEEELLRVSGGVDMSSHQE 273
EF L L + L +L+ E L +Q++A+ + A ED E V+ +E
Sbjct: 343 EFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVE--ELEE 400
Query: 274 VFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQECT 333
+ L K+ + A + ++ LE QL+ E V R + ++ Q T
Sbjct: 401 NISHLSEKLQDTENEA-----MSKIVELE-----KQLMQRNKELDVVREIYKDANTQVHT 450
Query: 334 LEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAA 393
L ++V+ R Q+ L++ Q T + +G
Sbjct: 451 LRKMVKEKEEAIQR-------------QSTLEKKIHELEKQGTIKIQKKGDGDI------ 491
Query: 394 CEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKA 453
+IL V L + P + +S+ P PPPPPP
Sbjct: 492 ----------AILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPP--------- 532
Query: 454 LPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWG 513
LP + P G + PP PP PPP P PPPPPP PPPPPP LPG
Sbjct: 533 LPPSSDTPETVQNGPVTPPMPPPPPPPP------PPPPPP------PPPPPPPLPGPAAE 580
Query: 514 PPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLP 573
P PP P +PP+ G +V + GL + + ++ RM NW L
Sbjct: 581 TVPAPPLAPPLPSAPPLPGTSSPTVV--FNSGLAAVKI---KKPIKTKFRMPVFNWVALK 635
Query: 574 SNVAREHNSMWASLSSPDAEAVEPDFS--SIERLFSFPAAKPKEPTMVAPR--ARKEPKE 629
N + D E + D + E +F A P + + +K +
Sbjct: 636 PNQIN-----GTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKIPQKGSNK 690
Query: 630 ITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLR 689
+T L+A ++ NL I L++ + +E+ I D V+ ++ L++ LP ++E++ LR
Sbjct: 691 VTLLEANRAKNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLR 750
Query: 690 AFTEER---AKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACE 746
+ ER L+ D F + I ++ M A + M+ P+ ++AA
Sbjct: 751 LYERERKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASV 810
Query: 747 SLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLE 806
S+ +S++L ++IL +GN++N S G GFK+ +L L +TKS + TLLH++
Sbjct: 811 SIKSSQKLKKILEIILALGNYMN-SSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISN 869
Query: 807 EAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYT 866
++ + + +L +AA ++LE + + + + T+R+ ++ +
Sbjct: 870 VVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREY--TMHDHNTLLK 927
Query: 867 ERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKE 926
E + + + L + + + ++ Y E+ + F F + +A +E
Sbjct: 928 EFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEE 987
Query: 927 NKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRK 982
N+ RK+Q + ++L E+EA + + P K +Q+E L+A++R+
Sbjct: 988 NELRKKQ---EQALMEKLLEQEALMEQQDPKSPSHKSKRQQQE------LIAELRR 1034
>gi|145309324 FH2 domain containing 1 [Homo sapiens]
Length = 1143
Score = 233 bits (595), Expect = 7e-61
Identities = 155/500 (31%), Positives = 246/500 (49%), Gaps = 55/500 (11%)
Query: 466 LGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGC---------PPPPPPLLPGMGWGPPP 516
+G PPAPP PPP PPPP P C PPPPPP LPG P P
Sbjct: 26 IGQTPPPAPPPPPP----------PPPPSPPCSCSREECPSSPPPPPPPPLPGEP--PIP 73
Query: 517 PPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNV 576
PPPP LP T H G + + +R M+ W+ +P
Sbjct: 74 PPPPGLPPTT-----------------HMNGYSHLGKKKR-------MRSFFWKTIPEEQ 109
Query: 577 AREHNSMWASLSSPDAEAVEPDFSSIERLF-----SFPAAKPKEPTMVAPRARKEPKEIT 631
R ++W +L++ + D +IE LF + ++ P+ + R+ +EIT
Sbjct: 110 VRGKTNIW-TLAARQEHHYQIDTKTIEELFGQQEDTTKSSLPRRGRTLNSSFREAREEIT 168
Query: 632 FLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAF 691
LDAK+S+N+ IFLKQFK S + I G + + E L++ LK LPE E++ L+AF
Sbjct: 169 ILDAKRSMNIGIFLKQFKKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAF 228
Query: 692 TEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTS 751
+ + +KL+ AD F L+ +P Y LRIE M+L + + ++ A + L++
Sbjct: 229 SGDVSKLSLADSFLYGLIQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSC 288
Query: 752 RQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKS 811
+L L+L+ GN +N G + G+A GFK+S+LLKL +TK+ + + LLH V +EA+K
Sbjct: 289 EELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKK 348
Query: 812 HPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQA 871
LL L + A ++LE +E + + + E+ +Q + LQ
Sbjct: 349 DTILLNFSEKLHHVQKTARLSLENTEAELHLLFVRTKSLKENIQRD-GELCQQMEDFLQF 407
Query: 872 SISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRK 931
+I R L+ + ++ + L D+ CED + + L++ F + F F +A+K+N DR+
Sbjct: 408 AIEKLRELECWKQELQDEAYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDRE 467
Query: 932 EQAAKAERRKQQLAEEEARR 951
Q R+ Q+L E+E ++
Sbjct: 468 AQEL---RQLQRLKEQEQKQ 484
Score = 64.7 bits (156), Expect = 5e-10
Identities = 33/64 (51%), Positives = 35/64 (54%), Gaps = 14/64 (21%)
Query: 420 TPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAK--ALPTAPPPPPLPGLGAMAPPAPPLP 477
TPPP PPPP PPPPPP PP + + P PPPPPLPG PP PP P
Sbjct: 29 TPPPAPPPP--------PPPPPPSPPCSCSREECPSSPPPPPPPPLPG----EPPIPPPP 76
Query: 478 PPLP 481
P LP
Sbjct: 77 PGLP 80
Score = 56.2 bits (134), Expect = 2e-07
Identities = 28/52 (53%), Positives = 29/52 (55%), Gaps = 9/52 (17%)
Query: 418 ASTPPPPPPPPLLPGSSAEP-----PPPPPPPPLPSVGAKALPTAPPPPPLP 464
A PPPPPPPP P S + PPPPPPPPLP P PPPP LP
Sbjct: 33 APPPPPPPPPPSPPCSCSREECPSSPPPPPPPPLPG----EPPIPPPPPGLP 80
Score = 48.9 bits (115), Expect = 3e-05
Identities = 23/33 (69%), Positives = 25/33 (75%), Gaps = 4/33 (12%)
Query: 415 EQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLP 447
E+ S+PPPPPPPP LPG EPP PPPPP LP
Sbjct: 52 EECPSSPPPPPPPP-LPG---EPPIPPPPPGLP 80
>gi|119120861 formin-like 3 isoform 2 [Homo sapiens]
Length = 976
Score = 214 bits (546), Expect = 3e-55
Identities = 237/946 (25%), Positives = 396/946 (41%), Gaps = 169/946 (17%)
Query: 63 GWMVQFL--EQSGLDLLLEALA---------RLSGRGVARISDALLQL----TCVSCVRA 107
GW+ +FL E GLD+L++ L+ L GR + S + Q C+ C+RA
Sbjct: 123 GWVREFLNDENKGLDVLVDYLSFAQCSVMYSTLPGRRALKNSRLVSQKDDVHVCILCLRA 182
Query: 108 VMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDH 167
+MN + G ++S+ V +++ +L+ N K V ELLAA+C+ GH + L A D+
Sbjct: 183 IMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRG-GHEIILAAFDN 241
Query: 168 YKTVCSQQYRFSIVMNELSGSD-NVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQL 226
+K VC + +RF +M D N+ ++V + IN V+ ED+ R L+ EF L L
Sbjct: 242 FKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGL 301
Query: 227 LDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSP 286
+ L + R E L +Q++A+ + + V G ++ + + V
Sbjct: 302 EEFLQKSRHTESEKLQVQIQAYLD-------NVFDVGGLLEDAETKNV------------ 342
Query: 287 VSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKG 346
L+ + LE + L E L L N ++ ++ ++ L+ E L S+K
Sbjct: 343 -------ALEKVEELEEHVSH---LTEKLLDLENENMMRVAELEKQLLQREKE-LESIKE 391
Query: 347 RPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESIL 406
+ +H+ ++ + Q +P+V G ++ SE++
Sbjct: 392 TYENT----SHQVHTLRRLIKEKEEAFQRRCHLEPNVRG-----------LESVDSEALA 436
Query: 407 KVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGL 466
+V E PP LL P PPP LP PPPP
Sbjct: 437 RVGPAELSEGM-----PPSDLDLLA------PAPPPEEVLP---------LPPPP----- 471
Query: 467 GAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTC 526
APP PP PPPLP C PP PPLPG P L G+
Sbjct: 472 ---APPLPPPPPPLPDKC----PPAPPLPGAA---PSVVLTVGL---------------- 505
Query: 527 SPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPP---TLRMKKLNWQKLPSNVAREHNSM 583
S R+ P R+ NW L N + ++
Sbjct: 506 --------------------------SAIRIKKPIKTKFRLPVFNWTALKPN--QISGTV 537
Query: 584 WASLSSPDAEAVEP-DFSSIERLFSFPAAKPKEPTMVAPR--ARKEPKEITFLDAKKSLN 640
++ L D + +E D E LF A P + + A+K ++T L+A ++ N
Sbjct: 538 FSELD--DEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKN 595
Query: 641 LNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEER---AK 697
L I L++ S EE+ I D V+ ++ L++ LP + E++ LR + ER +
Sbjct: 596 LAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEE 655
Query: 698 LASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIF 757
LA+ D F LL + R+ M L M+ P+ ++AA S+ +S++L
Sbjct: 656 LAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQM 715
Query: 758 CQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQ 817
++IL +GN++N S G GFK+ +L L +TKS ++TLLH + ++ +PDL
Sbjct: 716 LEIILALGNYMN-SSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLAN 774
Query: 818 LPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQASISAFR 877
+L +AA ++LE + + + + R+ S V + L +
Sbjct: 775 FWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNF---LSTNEGKLD 831
Query: 878 ALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKA 937
L + E+ + Y E + F F + A +EN+ RK+Q +
Sbjct: 832 KLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQ--EE 889
Query: 938 ERRKQQLAEEEARRPRGEDGK-PVRKGPGKQEEVCVIDALLADIRK 982
R++QLA+E + D K P ++ +Q+E L+A++R+
Sbjct: 890 VMREKQLAQEAKKL----DAKTPSQRNKWQQQE------LIAELRR 925
>gi|119120874 formin-like 3 isoform 1 [Homo sapiens]
Length = 1027
Score = 206 bits (523), Expect = 1e-52
Identities = 222/893 (24%), Positives = 373/893 (41%), Gaps = 154/893 (17%)
Query: 101 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVL 160
C+ C+RA+MN + G ++S+ V +++ +L+ N K V ELLAA+C+ GH +
Sbjct: 227 CILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRG-GHEI 285
Query: 161 TLDALDHYKTVCSQQYRFSIVMNELSGSD-NVPYVVTLLSVINAVILGPEDLRARTQLRN 219
L A D++K VC + +RF +M D N+ ++V + IN V+ ED+ R L+
Sbjct: 286 ILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQY 345
Query: 220 EFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLF 279
EF L L + L + R E L +Q++A+ + + V G ++ + + V
Sbjct: 346 EFTKLGLEEFLQKSRHTESEKLQVQIQAYLD-------NVFDVGGLLEDAETKNV----- 393
Query: 280 HKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVE 339
L+ + LE + L E L L N ++ ++ ++ L+ E
Sbjct: 394 --------------ALEKVEELEEHVSH---LTEKLLDLENENMMRVAELEKQLLQREKE 436
Query: 340 RLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDH 399
L S+K + +H+ ++ + Q +P+V G ++
Sbjct: 437 -LESIKETYENT----SHQVHTLRRLIKEKEEAFQRRCHLEPNVRG-----------LES 480
Query: 400 AQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPP 459
SE++ +V E PP LL P PPP LP PP
Sbjct: 481 VDSEALARVGPAELSEGM-----PPSDLDLLA------PAPPPEEVLP---------LPP 520
Query: 460 PPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPP 519
PP APP PP PPPLP C PP PPLPG P L G+
Sbjct: 521 PP--------APPLPPPPPPLPDKC----PPAPPLPGAA---PSVVLTVGL--------- 556
Query: 520 PLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPP---TLRMKKLNWQKLPSNV 576
S R+ P R+ NW L N
Sbjct: 557 ---------------------------------SAIRIKKPIKTKFRLPVFNWTALKPN- 582
Query: 577 AREHNSMWASLSSPDAEAVEP-DFSSIERLFSFPAAKPKEPTMVAPR--ARKEPKEITFL 633
+ ++++ L D + +E D E LF A P + + A+K ++T L
Sbjct: 583 -QISGTVFSELD--DEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLL 639
Query: 634 DAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTE 693
+A ++ NL I L++ S EE+ I D V+ ++ L++ LP + E++ LR +
Sbjct: 640 EANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYER 699
Query: 694 ER---AKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLT 750
ER +LA+ D F LL + R+ M L M+ P+ ++AA S+ +
Sbjct: 700 ERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKS 759
Query: 751 SRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEK 810
S++L ++IL +GN++N S G GFK+ +L L +TKS ++TLLH + ++
Sbjct: 760 SQKLKQMLEIILALGNYMN-SSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKE 818
Query: 811 SHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQ 870
+PDL +L +AA ++LE + + + + R+ S V + L
Sbjct: 819 KYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNF---LS 875
Query: 871 ASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDR 930
+ L + E+ + Y E + F F + A +EN+ R
Sbjct: 876 TNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEAR 935
Query: 931 KEQAAKAERRKQQLAEEEARRPRGEDGK-PVRKGPGKQEEVCVIDALLADIRK 982
K+Q + R++QLA+E + D K P ++ +Q+E L+A++R+
Sbjct: 936 KKQ--EEVMREKQLAQEAKKL----DAKTPSQRNKWQQQE------LIAELRR 976
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 194 bits (494), Expect = 3e-49
Identities = 177/598 (29%), Positives = 268/598 (44%), Gaps = 72/598 (12%)
Query: 418 ASTPPPPP-------PPPLLPGSSAEPPPP------PPPPPLPSVGAKALPTAP-----P 459
A PPPPP PPP LPG+ PPPP PPPPPLP G P P P
Sbjct: 1116 AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPP 1175
Query: 460 PPPLPGLGAMAPPAPPLP-------PPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGW 512
PPPLPG+G PP PPLP PPLPG+ PPPPPLPG+G PP P P LP G
Sbjct: 1176 PPPLPGVGI--PPPPPLPGVGIPPPPPLPGAGI---PPPPPLPGMGIPPAPAPPLPPPGT 1230
Query: 513 GPPPPP------PPLLPCTCS-----PPVAGGMEEVIVAQVDHGLG-SAWVPSHRRVNPP 560
G PPPP PPLLP S P V G + + + + GLG + S ++ P
Sbjct: 1231 GIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGL-FGLGMNQDKGSRKQPIEP 1289
Query: 561 TLRMKKLNWQKLPSNVAREHNS--MWASLSSPDAEAVEPDFSSIERLFSFPAAKP-KEPT 617
MK L W ++ + R+ ++ +W + P + E E LFS A K K+P
Sbjct: 1290 CRPMKPLYWTRIQLHSKRDSSTSLIWEKIEEPSIDCHE-----FEELFSKTAVKERKKPI 1344
Query: 618 MVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLK 677
K + + L K+S + I + +++ + D + D+E L+ L +
Sbjct: 1345 SDTISKTKAKQVVKLLSNKRSQAVGILMSSLHLDMKDIQHAVVNLDNSVVDLETLQALYE 1404
Query: 678 LLPEKHEIENLR-----AFTEERAK-LASADHFYLLLLAIPCYQLRIECMLLCEGAAAVL 731
+ E+E + + +E AK L + F L IP + R+ C+L + +
Sbjct: 1405 NRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYELSLIPNFSERVFCILFQSTFSESI 1464
Query: 732 DMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHT-GDADGFKISTLLKLTE 790
+R K +L+ CE+L + L+L GN++N G+ T G ADGF + L KL +
Sbjct: 1465 CSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNYMNGGNKTRGQADGFGLDILPKLKD 1524
Query: 791 TKSQQNRVTLLHHVL--------EEAEKSHPDL-LQLPRDLEQPSQAAGINLEIIRSEAS 841
KS N +LL +++ E+A K L P+DL Q SQ + + +
Sbjct: 1525 VKSSDNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLPEPQDLFQASQMKFEDFQKDLRKLK 1584
Query: 842 SNLKKL-LETERKVSASVAEVQEQYTERLQASISAFRALDELFE-AIEQKQRELADYLCE 899
+LK +E + S E + + E ++ I + E E ++ + + +
Sbjct: 1585 KDLKACEVEAGKVYQVSSKEHMQPFKENMEQFIIQAKIDQEAEENSLTETHKCFLETTAY 1644
Query: 900 DAQQLSLEDTFSTMKAFRDLFLRALKENKD--RKEQAAKAERRKQQLAEEEARRPRGE 955
+ L + + AF ++ + KD +KE + R ++ AEE R+ +G+
Sbjct: 1645 FFMKPKLGEKEVSPNAFFSIWHEFSSDFKDFWKKENKLLLQERVKE-AEEVCRQKKGK 1701
Score = 125 bits (315), Expect = 2e-28
Identities = 74/144 (51%), Positives = 76/144 (52%), Gaps = 39/144 (27%)
Query: 418 ASTPPPPP-------PPPLLPGSSAEPPPP------PPPPPLPSVGAKALPTAP-----P 459
A PPPPP PPP LPG+ PPPP PPPPPLP G P P P
Sbjct: 1028 AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1087
Query: 460 PPPLPGLGAMAPPAPPL-------PPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGW 512
PPPLPG G PP PPL PPPLPG+ PPPPPLPG G PPPPP LPG G
Sbjct: 1088 PPPLPGAGI--PPPPPLPGVGIPPPPPLPGAG---IPPPPPLPGAGIPPPPP--LPGAGI 1140
Query: 513 GPPP-------PPPPLLPCTCSPP 529
PPP PPPP LP PP
Sbjct: 1141 PPPPPLPRVGIPPPPPLPGAGIPP 1164
Score = 125 bits (314), Expect = 2e-28
Identities = 73/139 (52%), Positives = 75/139 (53%), Gaps = 40/139 (28%)
Query: 418 ASTPPPPP-------PPPLLPGSSAEPPPP------PPPPPLPSVGAKALPTAPPPPPLP 464
A PPPPP PPP LPG+ PPPP PPPPPLP G PPPPPLP
Sbjct: 973 AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI------PPPPPLP 1026
Query: 465 GLGAMAPPAPPL-------PPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPP- 516
G G PP PPL PPPLPG+ PPPPPLPG G PPPPP LPG G PPP
Sbjct: 1027 GAGI--PPPPPLPGAGIPPPPPLPGAG---IPPPPPLPGAGIPPPPP--LPGAGIPPPPP 1079
Query: 517 ------PPPPLLPCTCSPP 529
PPPP LP PP
Sbjct: 1080 LPGAGIPPPPPLPGAGIPP 1098
Score = 125 bits (313), Expect = 3e-28
Identities = 73/141 (51%), Positives = 74/141 (52%), Gaps = 33/141 (23%)
Query: 418 ASTPPPPP-------PPPLLPGSSAEPPPP------PPPPPLPSVGAKALPTAP-----P 459
A PPPPP PPP LPG+ PPPP PPPPPLP VG P P P
Sbjct: 1061 AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPP 1120
Query: 460 PPPLPGLGAMAPPAPPLP----PPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPP 515
PPPLPG G PP PPLP PP P PPPPPLPG G PPPPP LPG G PP
Sbjct: 1121 PPPLPGAGI--PPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPP--LPGAGIPPP 1176
Query: 516 P-------PPPPLLPCTCSPP 529
P PPPP LP PP
Sbjct: 1177 PPLPGVGIPPPPPLPGVGIPP 1197
Score = 123 bits (308), Expect = 1e-27
Identities = 72/140 (51%), Positives = 76/140 (54%), Gaps = 33/140 (23%)
Query: 418 ASTPPPPP-------PPPLLPGSSAEPPPP------PPPPPLPSVGAKALPTAP-----P 459
A PPPPP PPP LPG+ PPPP PPPPPLP G P P P
Sbjct: 984 AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1043
Query: 460 PPPLPGLGAMAPPAPPLP-------PPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGW 512
PPPLPG G PP PPLP PPLPG+ PPPPPLPG G PPPPP LPG G
Sbjct: 1044 PPPLPGAGI--PPPPPLPGAGIPPPPPLPGAGI---PPPPPLPGAGIPPPPP--LPGAGI 1096
Query: 513 GPPPPPPPLLPCTCSPPVAG 532
PPPPP P + PP+ G
Sbjct: 1097 -PPPPPLPGVGIPPPPPLPG 1115
Score = 122 bits (307), Expect = 2e-27
Identities = 74/153 (48%), Positives = 78/153 (50%), Gaps = 38/153 (24%)
Query: 408 VSQPRALEQQASTPPPPPP------PPLLPGSSAEPPPP------PPPPPLPSVGAKALP 455
+ P L PPPP P PP LPG+ PPPP PPPPPLP G P
Sbjct: 997 IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1056
Query: 456 T-----APPPPPLPGLGAMAPPAPPL-------PPPLPGSCEFLPPPPPPLPGLGCPPPP 503
PPPPPLPG G PP PPL PPPLPG+ PPPPPLPG+G PPPP
Sbjct: 1057 PLPGAGIPPPPPLPGAG--IPPPPPLPGAGIPPPPPLPGAG---IPPPPPLPGVGIPPPP 1111
Query: 504 PPLLPGMGWGPPP-------PPPPLLPCTCSPP 529
P LPG G PPP PPPP LP PP
Sbjct: 1112 P--LPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1142
Score = 122 bits (305), Expect = 3e-27
Identities = 83/225 (36%), Positives = 100/225 (44%), Gaps = 54/225 (24%)
Query: 347 RPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESIL 406
+P P P S+ + Q Q GS P ++ + + + ++A + +
Sbjct: 809 QPPPPP------SLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLP 862
Query: 407 KVSQPRALEQQASTPPPPPP----------------PPLLPGSSAEPPPP--------PP 442
++ PPPPPP PP L G+ PPPP PP
Sbjct: 863 CTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPP 922
Query: 443 PPPLPSVGAKALPT-----APPPPPLPGLGAMAPPAP------PLPPPLPGSCEFLPPPP 491
PPPLP G LP PPPPPLPG A+ PP P PLPPPLPG+ PPP
Sbjct: 923 PPPLPGAGILPLPPLPGAGIPPPPPLPG-AAIPPPPPLPGAGIPLPPPLPGAG---IPPP 978
Query: 492 PPLPGLGCPPPPPPLLPGMGWGPPP-------PPPPLLPCTCSPP 529
PPLPG G PPPPP LPG G PPP PPPP LP PP
Sbjct: 979 PPLPGAGIPPPPP--LPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1021
Score = 120 bits (301), Expect = 8e-27
Identities = 72/148 (48%), Positives = 77/148 (52%), Gaps = 37/148 (25%)
Query: 408 VSQPRALEQQASTPPPPPP--------PPLLPGSSAEPPPP------PPPPPLPSVGAKA 453
+ QP L+ PPPPPP PP LPG+ P PP PPPPPLP
Sbjct: 896 IPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAI-- 953
Query: 454 LPTAPPPPPLPGLG-AMAPPAP----PLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLP 508
PPPPPLPG G + PP P P PPPLPG+ PPPPPLPG G PPPPP LP
Sbjct: 954 ----PPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAG---IPPPPPLPGAGIPPPPP--LP 1004
Query: 509 GMGWGPPP-------PPPPLLPCTCSPP 529
G G PPP PPPP LP PP
Sbjct: 1005 GAGIPPPPPLPGAGIPPPPPLPGAGIPP 1032
Score = 100 bits (249), Expect = 9e-21
Identities = 59/123 (47%), Positives = 65/123 (52%), Gaps = 18/123 (14%)
Query: 422 PPPPPPPLLPGSSAEPP---PPPPPPPLPSVGAKALPTA--PPPPPLPGLGAMAPPAPPL 476
P PPP P SS+ P PPPPPPLP + LP+ P PPPL G + PP PPL
Sbjct: 856 PSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPL 915
Query: 477 P-------PPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPP 529
P PPLPG+ P PPLPG G PPPPP LPG PPPPP P PP
Sbjct: 916 PGAGIPPPPPLPGAGIL---PLPPLPGAGIPPPPP--LPGAAI-PPPPPLPGAGIPLPPP 969
Query: 530 VAG 532
+ G
Sbjct: 970 LPG 972
Score = 33.9 bits (76), Expect = 0.99
Identities = 34/147 (23%), Positives = 53/147 (36%), Gaps = 9/147 (6%)
Query: 330 QECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPS------- 382
QE L ++ + + + + + L + Q L ++ ++P +P+P
Sbjct: 192 QEDLLSDIQQAIRLQQQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVSPQPGAFLGLDR 251
Query: 383 -VEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPP 441
+ G A A D Q+ S L P +L + P PP P LP S A P
Sbjct: 252 FLLGPSGGAGEAPGSPDTEQALSALS-DLPESLAAEPREPQQPPSPGGLPVSEAPSLPAA 310
Query: 442 PPPPLPSVGAKALPTAPPPPPLPGLGA 468
P S + A P P GA
Sbjct: 311 QPAAKDSPSSTAFPFPEAGPGEEAAGA 337
Score = 33.1 bits (74), Expect = 1.7
Identities = 28/94 (29%), Positives = 34/94 (36%), Gaps = 28/94 (29%)
Query: 451 AKALPTAPPP-------PPLPGLGAMAPPAPPLPP-----PLPGSCEFLP---------- 488
AK++ T+P PP+ GL P PP PP P C +
Sbjct: 741 AKSIQTSPTEEGGVLTLPPVDGL----PGRPPCPPGAESGPQTKFCSEISLIVSPRRISV 796
Query: 489 --PPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPP 520
P + PPPPP LL G G P PP
Sbjct: 797 QLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPP 830
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 168 bits (426), Expect = 3e-41
Identities = 156/535 (29%), Positives = 238/535 (44%), Gaps = 68/535 (12%)
Query: 396 PVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALP 455
P DH + L+ + A QQ + PPPP P PPPPLPS G +L
Sbjct: 621 PNDHKDIHAALQPMEGMASNQQKALPPPPASIP-------------PPPPLPS-GLGSLS 666
Query: 456 TAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPP 515
APP PP+ + PP PP PP P S PPPPPP P P PP P GPP
Sbjct: 667 PAPPMPPVSAGPPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNP------GGPP 720
Query: 516 PPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRR-VNPPTLRMKKLNWQKLPS 574
P PPP P PP G + GLGS+ R+ P+ MK L W ++
Sbjct: 721 PAPPP--PGLAPPPPPG---------LFFGLGSSSSQCPRKPAIEPSCPMKPLYWTRIQI 769
Query: 575 NVAREH--NSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEPTM--VAPRARKEPKEI 630
+ ++ ++W SL PD D S E LFS + K+ + + K K I
Sbjct: 770 SDRSQNATPTLWDSLEEPDIR----DPSEFEYLFSKDTTQQKKKPLSETYEKKNKVKKII 825
Query: 631 TFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRA 690
LD K+S + I + +++ I D + D+E L L + ++ E+ +R
Sbjct: 826 KLLDGKRSQTVGILISSLHLEMKDIQQAIFNVDDSVVDLETLAALYENRAQEDELVKIRK 885
Query: 691 F----TEERAKLASADHFYLLLLA-IPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAAC 745
+ EE KL +L LA IP + R +C++ + + + K +++ A
Sbjct: 886 YYETSKEEELKLLDKPEQFLHELAQIPNFAERAQCIIFRSVFSEGITSLHRKVEIITRAS 945
Query: 746 ESLLTSRQLPIFCQLILRIGNFLNYGSHT-GDADGFKISTLLKLTETKSQQNRVTLLHHV 804
+ LL + + LIL GN++N G+ T G ADG+ + L KL + KS+ N + L+ +V
Sbjct: 946 KDLLHVKSVKDILALILAFGNYMNGGNRTRGQADGYSLEILPKLKDVKSRDNGINLVDYV 1005
Query: 805 L--------EEA--EKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKV 854
+ +EA EKS L + P+D SQ +L +K L + +R++
Sbjct: 1006 VKYYLRYYDQEAGTEKSVFPLPE-PQDFFLASQVKFEDL----------IKDLRKLKRQL 1054
Query: 855 SASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDT 909
AS ++ E + + F+ E F +K+ ++ + E+AQ+ S E T
Sbjct: 1055 EASEKQMVVVCKESPKEYLQPFKDKLEEFFQKAKKEHKMEESHLENAQK-SFETT 1108
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 155 bits (393), Expect = 2e-37
Identities = 139/512 (27%), Positives = 219/512 (42%), Gaps = 78/512 (15%)
Query: 425 PPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSC 484
PPPPL PPPPPPLP AK + P A+A P L P+P
Sbjct: 750 PPPPL---------SPPPPPPLPFHDAKPSSRSSDGSRGPAQ-ALAKPLTQLSHPVP--- 796
Query: 485 EFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDH 544
PPPPPPL PPP P C+PP+ +
Sbjct: 797 ---------------PPPPPPL---------PPPVP-----CAPPM-----------LSR 816
Query: 545 GLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSP-DAEAVEPDFSSIE 603
GLG HRR + +K+L W++ V ++W L D + + ++
Sbjct: 817 GLG------HRRSETSHMSVKRLRWEQ----VENSEGTIWGQLGEDSDYDKLSDMVKYLD 866
Query: 604 RLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGD 663
F KP +P + P ++ + + L KK+ N +I L K S E+ ++ + +
Sbjct: 867 LELHFGTQKPAKP-VPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLSPAELRQVLMSME 925
Query: 664 TTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLL 723
+ + L QLL P+ E + +AF E +L+ D F L +L++P Y+ R+ +
Sbjct: 926 PRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRLRSLHF 985
Query: 724 CEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGS-HTGDADGFKI 782
+ +R + + A L SR+L + +L +GN+LN G T GFKI
Sbjct: 986 QATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKI 1045
Query: 783 STLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEAS- 841
+ L +L TK+ + T LH + + + P+LL +DL AA +N + S+ +
Sbjct: 1046 NFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVNQRALTSDLAD 1105
Query: 842 --SNLKKLLETERKVSAS----VAEVQEQYTERLQASISAFRALDEL-FEAIEQKQRELA 894
+ ++ + + +S S A V + E Q A RALD L EA+E+ + LA
Sbjct: 1106 LHGTISEIQDACQSISPSSEDKFAMVMSSFLETAQ---PALRALDGLQREAMEELGKALA 1162
Query: 895 DYLCEDAQQLSLEDTFSTMKAFRDLFLRALKE 926
+ ED++ + E F F F RAL +
Sbjct: 1163 -FFGEDSKATTSEAFFGIFAEFMSKFERALSD 1193
Score = 35.8 bits (81), Expect = 0.26
Identities = 18/39 (46%), Positives = 21/39 (53%), Gaps = 7/39 (17%)
Query: 412 RALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVG 450
+ L Q + PPPPPPPL PPP P PP+ S G
Sbjct: 786 KPLTQLSHPVPPPPPPPL-------PPPVPCAPPMLSRG 817
Score = 33.5 bits (75), Expect = 1.3
Identities = 49/193 (25%), Positives = 58/193 (30%), Gaps = 67/193 (34%)
Query: 387 QPAAAAACEPVDHAQSESILKVS-------QPRALEQQASTPP---PPPPPPLLPGS--- 433
+P EP Q S L+ S + + LE S P P P PL+PG
Sbjct: 478 EPELDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQA 537
Query: 434 --SAEPPPPPPPPPLPSV----------------GAKALPTAPPPPPLPGL--------G 467
P P P + +V G + A PP P P + G
Sbjct: 538 GDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSG 597
Query: 468 AMAPPAPPLPPPL-----------PGSCEFLP---------PPPPPLPGLGCPPPPPPLL 507
P LP P P S E P P P P PG CP PP
Sbjct: 598 VSWPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSPP--- 654
Query: 508 PGMGWGPPPPPPP 520
P P PP
Sbjct: 655 -----SPDPTRPP 662
Score = 33.5 bits (75), Expect = 1.3
Identities = 33/137 (24%), Positives = 49/137 (35%), Gaps = 20/137 (14%)
Query: 343 SVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQS 402
S+ P P + + +++ L+ S +G T K P+ A P
Sbjct: 542 SLPETPNPKMMSAVYAELESRLNSSFKGKMG---TVSKSRASPPGPSPAVTTGP------ 592
Query: 403 ESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPP 462
++ VS P P P PL G A P P +L ++ P P
Sbjct: 593 RTLSGVSWP-----SERLLPSPCYHPLCSGGLASPSSSESHP------YASLDSSRAPSP 641
Query: 463 LPGLGAMAPPAPPLPPP 479
PG G + P +PP P P
Sbjct: 642 QPGPGPICPDSPPSPDP 658
Score = 31.2 bits (69), Expect = 6.4
Identities = 25/83 (30%), Positives = 30/83 (36%), Gaps = 6/83 (7%)
Query: 367 SQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESIL-----KVSQPRA-LEQQAST 420
S G SP TT P+ P+ P H L S P A L+ +
Sbjct: 580 SPPGPSPAVTTGPRTLSGVSWPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAP 639
Query: 421 PPPPPPPPLLPGSSAEPPPPPPP 443
P P P P+ P S P P PP
Sbjct: 640 SPQPGPGPICPDSPPSPDPTRPP 662
>gi|11386183 WAS protein family, member 2 [Homo sapiens]
Length = 498
Score = 110 bits (275), Expect = 8e-24
Identities = 74/211 (35%), Positives = 93/211 (44%), Gaps = 19/211 (9%)
Query: 335 EEVVERLLSVKGRPRPSPLVKAHKSVQA--NLDQSQRGSSPQNTTTPKPSVEGQQ----P 388
+E VE + P LV + S+ N+D S PQ+ + PS + P
Sbjct: 210 QEFVESKEKLGTSGYPPTLVYQNGSIGCVENVDASSYPPPPQSDSASSPSPSFSEDNLPP 269
Query: 389 AAAAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPP---PLLPGSSAEPPPPPPPPP 445
A PVD+ + + + P+ + + PPP PP P P PPP PPPPP
Sbjct: 270 PPAEFSYPVDNQRGSGL---AGPKRSSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPP 326
Query: 446 LPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFL-PPPPPPLPGLGCPPPPP 504
P +G PPPPP G G+ P PP PP P +F PPPPPP P P PP
Sbjct: 327 PPMIGI------PPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPP 380
Query: 505 PLLPGMGWGPPPPPPPLLPCTCSPPVAGGME 535
P L G PPPPPP P PP G +
Sbjct: 381 PPLSQPTGGAPPPPPPPPPPGPPPPPFTGAD 411
>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
sapiens]
Length = 505
Score = 102 bits (255), Expect = 2e-21
Identities = 65/150 (43%), Positives = 75/150 (50%), Gaps = 23/150 (15%)
Query: 414 LEQQASTPPPP----PPPPLLPGSSAEPPPPPP-----PPPLPSVGAKALPTAPPPPPLP 464
L +QA PPPP PPPP P ++ PPPPP PPP PS A P PPPP P
Sbjct: 272 LRRQAPPPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPP-PPPPSRP 330
Query: 465 GLGAMAPPA----PPLPPPLPGSCEFLPPPPPP-LPGLG--CPPPPPPLLPGMGWGPPPP 517
+ PP PP PP LP S PPPPPP + G+G PPPPPP P P PP
Sbjct: 331 SVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPPPPP----PGPP 386
Query: 518 PPPLLPC--TCSPPVAGGMEEVIVAQVDHG 545
PPP LP P G + ++ Q+ G
Sbjct: 387 PPPGLPSDGDHQVPTTAGNKAALLDQIREG 416
Score = 100 bits (250), Expect = 7e-21
Identities = 60/140 (42%), Positives = 66/140 (47%), Gaps = 20/140 (14%)
Query: 405 ILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPP----PPPPPLPSVGAKALPTAPPP 460
I K A++ + PPPPPP G PPPP PPPPP G APPP
Sbjct: 259 IEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHNSGPPPPPARGRG------APPP 312
Query: 461 PPLPGLGAMAPPAPP------LPPPLPGSCEFLPPPPPPLPGL--GCPPPPPPLLPGMGW 512
PP A PP PP +PPP P PPPPP LP PPPPPP + G+G
Sbjct: 313 PPSRAPTAAPPPPPPSRPSVAVPPPPPN--RMYPPPPPALPSSAPSGPPPPPPSVLGVGP 370
Query: 513 GPPPPPPPLLPCTCSPPVAG 532
PPPPPP P PP G
Sbjct: 371 VAPPPPPPPPPPPGPPPPPG 390
Score = 73.9 bits (180), Expect = 9e-13
Identities = 47/119 (39%), Positives = 53/119 (44%), Gaps = 17/119 (14%)
Query: 369 RGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQASTPPPP---- 424
RG P P S PA P +++ + P + A PPPP
Sbjct: 284 RGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMY 343
Query: 425 -PPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPG 482
PPPP LP SSA PPPPPP + VG P APPPPP PP PP PPP PG
Sbjct: 344 PPPPPALP-SSAPSGPPPPPPSVLGVG----PVAPPPPP-------PPPPPPGPPPPPG 390
Score = 59.7 bits (143), Expect = 2e-08
Identities = 38/110 (34%), Positives = 44/110 (40%), Gaps = 23/110 (20%)
Query: 373 PQNTTTPKPSVEGQ-----QPAAAAACEPVDHAQSESILKVSQPR----------ALEQQ 417
P N+ P P G+ P+ A P S + V P AL
Sbjct: 294 PHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSS 353
Query: 418 ASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLG 467
A + PPPPPP +L PPPPPPPPP P PPPP LP G
Sbjct: 354 APSGPPPPPPSVLGVGPVAPPPPPPPPPPPG--------PPPPPGLPSDG 395
>gi|118572599 formin homology 2 domain containing 1 [Homo sapiens]
Length = 1164
Score = 99.8 bits (247), Expect = 1e-20
Identities = 175/734 (23%), Positives = 293/734 (39%), Gaps = 127/734 (17%)
Query: 395 EPVDHAQSESILKVSQPRALEQQASTPPP----PPPPPLLPGSSAEPPPPPPPPPLPSVG 450
E V A++E + ++Q RA + P P L P P P P V
Sbjct: 445 ENVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSPAPCVL 504
Query: 451 AKALPTAPPPPPLPGLGAMAPPAPP---LPPPLP----GSCEF----------------- 486
+A + P P P + A +P A P LP P G +F
Sbjct: 505 LRAQRSLAPEPKEPLIPA-SPKAEPIWELPTRAPRLSIGDLDFSDLGEDEDQDMLNVESV 563
Query: 487 -----LPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQ 541
+P P PPLP L PPPPPL P P PPPP LP + A
Sbjct: 564 EAGKDIPAPSPPLPLLSGVPPPPPLPPPPPIKGPFPPPPPLP--------------LAAP 609
Query: 542 VDHGL-GSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHN----------SMWASLSSP 590
+ H + S+ +P+ R+ KL W++L +A H ++WASL
Sbjct: 610 LPHSVPDSSALPTKRKT-------VKLFWREL--KLAGGHGVSASRFGPCATLWASL--- 657
Query: 591 DAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKC 650
+ V D + +E LF AK P+ A R+ T LD K+S +NI L
Sbjct: 658 --DPVSVDTARLEHLFE-SRAKEVLPSKKAGEGRR--TMTTVLDPKRSNAINIGLTTLPP 712
Query: 651 SNEEVAAMIRAGD--TTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLL 708
+ AA++ + +K +E L ++ E+ +IE + + L A++F + L
Sbjct: 713 VHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPD-IPLGPAENFLMTL 771
Query: 709 LAIPCYQLRIECMLL-CEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNF 767
+I R++ + + ++ P L + E L+ + +L +GNF
Sbjct: 772 ASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKV-GMEQLVQNATFRCILATLLAVGNF 830
Query: 768 LNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQ 827
LN GS + GF++S L K++E K R +LLHH+ ++ P+ L ++ ++
Sbjct: 831 LN-GS---QSSGFELSYLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTR 886
Query: 828 AAGINLEIIRSEASSNLKKLLETERKVSASVAEV-QEQYTERLQASISAFRALDELFEAI 886
A ++ E + + NL +L R S+ + + + L+A ++ F LD+ +
Sbjct: 887 CAKVDFE----QLTENLGQLERRSRAAEESLRSLAKHELAPALRARLTHF--LDQCARRV 940
Query: 887 EQKQ---RELAD----------YLCEDAQQLSLEDTFSTMKAFRDLFLRALKEN--KDRK 931
+ R + + Y + A+++ + T++ F L R +E + ++
Sbjct: 941 AMLRIVHRRVCNRFHAFLLYLGYTPQAAREVRIMQFCHTLREFA-LEYRTCRERVLQQQQ 999
Query: 932 EQAAKAERRK---QQLAEEE-----ARRPRGEDGKP--VRKGPGK--QEEVCVIDALLAD 979
+QA ER K + + E E A P V GPG+ + + +LL
Sbjct: 1000 KQATYRERNKTRGRMITETEKFSGVAGEAPSNPSVPVAVSSGPGRGDADSHASMKSLLTS 1059
Query: 980 IRKGFQLRKTARGRGD-------TDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPAS 1032
+ + +RG T G S A+ +PP ++ P TS+ D + + +S
Sbjct: 1060 RPEDTTHNRRSRGMVQSSSPIMPTVGPSTASPEEPPGSSLPSDTSDEIMDLLVQSVTKSS 1119
Query: 1033 EPGLDATTASESRG 1046
L A SRG
Sbjct: 1120 PRALAARERKRSRG 1133
>gi|58331242 formin homology 2 domain containing 3 [Homo sapiens]
Length = 1439
Score = 98.6 bits (244), Expect = 3e-20
Identities = 100/372 (26%), Positives = 162/372 (43%), Gaps = 36/372 (9%)
Query: 498 GCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGM--EEVIVAQVDHGLGSAWVPSHR 555
G PPPPPP G+ PPPPPPPLL PPV G + V GLG + VP +
Sbjct: 845 GPPPPPPPTFLGL---PPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGLGWSQVPRGQ 901
Query: 556 RVNPPTLRMKKLNWQKLP------SNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFP 609
+ +L W ++ N R +W+ L E ++ D S +E LF
Sbjct: 902 PTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKL-----EPIKVDTSRLEHLFE-- 954
Query: 610 AAKPKEPTMVAPRARK-EPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFD 668
+K KE ++ A + +EI LD+K+S +NI L A++ D +
Sbjct: 955 -SKSKELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRTIKIAILNF-DEYALN 1012
Query: 669 VEVLKQLLKLLP---EKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCE 725
E ++++L ++P EK +I+ + E L SA+ F L L +I R+
Sbjct: 1013 KEGIEKILTMIPTDEEKQKIQEAQLANPE-IPLGSAEQFLLTLSSISELSARLHLWAFKM 1071
Query: 726 GAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTL 785
V + + L ++ L +L IGNFLN +A F++S L
Sbjct: 1072 DYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLN----GTNAKAFELSYL 1127
Query: 786 LKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLK 845
K+ E K ++ +LLHHV ++ PD L ++ +++A ++ + ++
Sbjct: 1128 EKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQD------- 1180
Query: 846 KLLETERKVSAS 857
L + ER+ AS
Sbjct: 1181 NLCQMERRCKAS 1192
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 98.2 bits (243), Expect = 4e-20
Identities = 69/191 (36%), Positives = 88/191 (46%), Gaps = 34/191 (17%)
Query: 350 PSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPS--VEGQQPAAAAACEPVDHAQSESILK 407
PSP + + ++ NL+ SS + + K E A +A +P ++
Sbjct: 1360 PSPCKRLDEELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTP 1419
Query: 408 VSQPRALEQQASTPPPPPPPPLLPGSSA----EPP-----PPPPPPPLPSVGAKALPTAP 458
P A A+ P PPP P LP +++ EPP PPP PPP P+ + P P
Sbjct: 1420 DGPPLA---PAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPT--PQPQPPPP 1474
Query: 459 PPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPP 518
PPPP P L P PPL P P S PPPPPLP PPPPP +P PPPPP
Sbjct: 1475 PPPPQPAL----PSPPPLVAPTPSS-----PPPPPLP-----PPPPPAMPS----PPPPP 1516
Query: 519 PPLLPCTCSPP 529
PP +PP
Sbjct: 1517 PPAAAPLAAPP 1527
Score = 89.4 bits (220), Expect = 2e-17
Identities = 74/221 (33%), Positives = 92/221 (41%), Gaps = 34/221 (15%)
Query: 371 SSPQNTTTPKPSVEGQQPAAAAACE---PVDHAQSESILKVSQPRALEQQASTPPPPPPP 427
+ P++T+TP +G A AAA P+ S + +P LE++ PPP PPP
Sbjct: 1411 AGPKDTSTP----DGPPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEK---PPPTPPP 1463
Query: 428 PLLPGSSAEPPPPPPPPPLPSVGAKALPT--APPPPPLPGLGAMAPPAPPLPPPLPGSCE 485
P PPPPPP P LPS PT +PPPPPLP PP PP P P
Sbjct: 1464 APTPQPQPPPPPPPPQPALPSPPPLVAPTPSSPPPPPLP------PPPPPAMPSPP---- 1513
Query: 486 FLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIV-AQVDH 544
PPPPP L PP P P P P LP T +A E V + D
Sbjct: 1514 --PPPPPAAAPLAAPPEEP--------AAPSPEDPELPDTRPLHLAKKQETAAVCGETDE 1563
Query: 545 GLG-SAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMW 584
G S R + +R + + KL RE +W
Sbjct: 1564 EAGESGGEGIFRERDEFVIRAEDIPSLKLALQTGREPPPIW 1604
Score = 59.3 bits (142), Expect = 2e-08
Identities = 52/148 (35%), Positives = 60/148 (40%), Gaps = 34/148 (22%)
Query: 423 PPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPP---LPGLGAMAPPAPP---- 475
PPPPPP +A+ P P L G LP PPPP LP + + AP P
Sbjct: 764 PPPPPP-----TAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASK 818
Query: 476 -----LPPPLPGSCEFLPPPPPPLPGLGCPPPPPPL-----LPGMGWGPPPPPPPLLP-C 524
L P PPPPPP PPPP PL L G P P P L P
Sbjct: 819 VGVHLLEPATRDGAPQPPPPPPP------PPPPMPLQLEAHLRSHGLEPAAPSPRLRPEE 872
Query: 525 TCSPPVA-----GGMEEVIVAQVDHGLG 547
+ PP A G +E + A D G+G
Sbjct: 873 SLDPPGAMQELLGALEPLPPAPGDTGVG 900
Score = 54.3 bits (129), Expect = 7e-07
Identities = 55/189 (29%), Positives = 58/189 (30%), Gaps = 73/189 (38%)
Query: 414 LEQQASTPPPPPP---PPLLPGSSAEPPPP--PPPPPLPSVGAKALPTAPPPPPLPGLGA 468
L Q TPP PP PP +P +P PP P P P GA L A GLG
Sbjct: 1298 LYQAGLTPPLSPPKSVPPSVPARGLQPQPPATPAVPHPPPSGAFGLGGALEAAESEGLGL 1357
Query: 469 MAP-PAPPLPPPLPGSCEFLP--------------------------------------- 488
P P L L + E LP
Sbjct: 1358 GCPSPCKRLDEELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDTS 1417
Query: 489 -------------PPPPPLPGLGC---------------PPPPPPLLPGMGWGPPPPPPP 520
P PPPLPGL PPP PP P PPPPPPP
Sbjct: 1418 TPDGPPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPP 1477
Query: 521 LLPCTCSPP 529
P SPP
Sbjct: 1478 PQPALPSPP 1486
Score = 50.4 bits (119), Expect = 1e-05
Identities = 41/114 (35%), Positives = 43/114 (37%), Gaps = 27/114 (23%)
Query: 423 PPPPPPLLPGSSAEPPPPPPP---------PPLPSVGAKALPTAPPPPPLP--------- 464
PPPPP LLP + P P P P GA P PPPPP P
Sbjct: 795 PPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPPPPPPPPPPPMPLQLEAHL 854
Query: 465 ---GLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPP 515
GL A P+P L P E L PP LG P PP G GPP
Sbjct: 855 RSHGL-EPAAPSPRLRPE-----ESLDPPGAMQELLGALEPLPPAPGDTGVGPP 902
Score = 50.1 bits (118), Expect = 1e-05
Identities = 60/223 (26%), Positives = 78/223 (34%), Gaps = 40/223 (17%)
Query: 372 SPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQ---PRALEQQASTPPPPPPPP 428
+P +T P+ EG+ PA A ++ + ++ P +L Q P
Sbjct: 893 APGDTGVGPPNSEGKDPAGAYRSPSPQGTKAPRFVPLTSICFPDSLLQDEERSFFPTMEE 952
Query: 429 LLPGSSAEP---PPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCE 485
+ G +A+ PP P GA PPP P P P P PG
Sbjct: 953 MFGGGAADDYGKAGPPEDEGDPKAGA-----GPPPGP--------PAYDPYGPYCPGRAS 999
Query: 486 FLPPPPPPLPGLGCPPPPPPLLPG---------------MGWGPPPPPPPLLPCTCSPPV 530
P PGLG P PP LP PPPPPPP P S P
Sbjct: 1000 ---GAGPETPGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAAPPPPPPPPPPPAPASEP- 1055
Query: 531 AGGMEEVIVAQVDHG--LGSAWVPSHRRVNPPTLRMKKLNWQK 571
GG+ I L ++ RR +PP KKL Q+
Sbjct: 1056 KGGLTSPIFCSTKPKKLLKTSSFHLLRRRDPPFQTPKKLYAQE 1098
Score = 42.0 bits (97), Expect = 0.004
Identities = 30/89 (33%), Positives = 31/89 (34%), Gaps = 10/89 (11%)
Query: 423 PPPPPPLLPGSSAEPPPPPPPPPLP-------SVGAKALPTAPPPPPLPGLGAMAPPAPP 475
P PP PG P PPPPP LP S A A P L AP PP
Sbjct: 221 PAQTPPYRPGP---PDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSGAAPGPPP 277
Query: 476 LPPPLPGSCEFLPPPPPPLPGLGCPPPPP 504
LP + P PPPPP
Sbjct: 278 PERALPRQDTVIKHYQRPASAQPPPPPPP 306
Score = 39.7 bits (91), Expect = 0.018
Identities = 34/111 (30%), Positives = 41/111 (36%), Gaps = 37/111 (33%)
Query: 389 AAAAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPG-----------SSAEP 437
AAAAA E S P+ + P PPPP LP +SA+P
Sbjct: 253 AAAAAAEQ------------SSPQLYNFSGAAPGPPPPERALPRQDTVIKHYQRPASAQP 300
Query: 438 PPPPPPP-----------PLPSVGAKALPTAPP---PPPLPGLGAMAPPAP 474
PPPPPP PS+G +A P P PG G + P
Sbjct: 301 PPPPPPAHALQHYLSCGGSYPSMGHRANLACSPLGGGEPSPGAGEPSKAGP 351
Score = 39.7 bits (91), Expect = 0.018
Identities = 31/91 (34%), Positives = 33/91 (36%), Gaps = 34/91 (37%)
Query: 466 LGAMAPPAPPLPPPLPGSCE------FLPPPPPPLPGLGCPPPPPPLLP----------- 508
LGA +PP PPP S + L P LP L PPPPP LLP
Sbjct: 756 LGAFLQKSPPPPPPTAQSTQPTPHGLLLEAGGPDLP-LVLPPPPPQLLPSVLSHAPSPSP 814
Query: 509 ----------------GMGWGPPPPPPPLLP 523
G PPPPPPP P
Sbjct: 815 SASKVGVHLLEPATRDGAPQPPPPPPPPPPP 845
Score = 37.0 bits (84), Expect = 0.12
Identities = 26/83 (31%), Positives = 33/83 (39%), Gaps = 9/83 (10%)
Query: 403 ESILKVSQPRALEQQASTPPPPP-------PPPLLPGSSAEPPPP-PPPPPLPSVGAKAL 454
E++ K R ++ PP P P+ G S+ PPP P PPP P K
Sbjct: 1651 ENVNKKDYVRVCARKPWHRPPVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKT- 1709
Query: 455 PTAPPPPPLPGLGAMAPPAPPLP 477
+ PP P PPAP P
Sbjct: 1710 TSEKPPEQTPETAMPEPPAPEKP 1732
Score = 35.4 bits (80), Expect = 0.34
Identities = 30/81 (37%), Positives = 33/81 (40%), Gaps = 19/81 (23%)
Query: 427 PPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPP-----LP 481
PPL + PP PP PSV A+ L PP A PA P PPP L
Sbjct: 1296 PPLYQ-AGLTPPLSPPKSVPPSVPARGLQPQPP----------ATPAVPHPPPSGAFGLG 1344
Query: 482 GSCEFLPPPPPPLPGLGCPPP 502
G+ E GLGCP P
Sbjct: 1345 GALEAAESEG---LGLGCPSP 1362
Score = 34.7 bits (78), Expect = 0.58
Identities = 24/78 (30%), Positives = 29/78 (37%), Gaps = 8/78 (10%)
Query: 435 AEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCE--FLPPPPP 492
A P PP P+ G P + G + PP P PPP P + E PP
Sbjct: 1663 ARKPWHRPPVPVRRSGQAKNPVSA------GGSSAPPPKAPAPPPKPETPEKTTSEKPPE 1716
Query: 493 PLPGLGCPPPPPPLLPGM 510
P P PP P P +
Sbjct: 1717 QTPETAMPEPPAPEKPSL 1734
Score = 33.1 bits (74), Expect = 1.7
Identities = 43/157 (27%), Positives = 61/157 (38%), Gaps = 39/157 (24%)
Query: 461 PPLPGLGAMAPPAPP--LPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPP 518
PPL G P +PP +PP +P L P PP P + P PPP G+G
Sbjct: 1296 PPLYQAGLTPPLSPPKSVPPSVPA--RGLQPQPPATPAV--PHPPPSGAFGLG------- 1344
Query: 519 PPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAR 578
G +E A GLG +R++ K N + LPS +
Sbjct: 1345 -------------GALE----AAESEGLGLGCPSPCKRLDEEL----KRNLETLPSFSSD 1383
Query: 579 EHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKE 615
E +S+ + + + E S+I L P A PK+
Sbjct: 1384 EEDSV-----AKNRDLQESISSAISALDDPPLAGPKD 1415
Score = 31.2 bits (69), Expect = 6.4
Identities = 31/123 (25%), Positives = 39/123 (31%), Gaps = 22/123 (17%)
Query: 1000 SKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQP 1059
S +++D P P TS P G P+ P L ++ S G TP P P
Sbjct: 1400 SAISALDDPPLAGPKDTSTPDGPPLAPAAAVPGPPPLPGLPSANSNG-------TPEP-P 1451
Query: 1060 TLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSN 1119
LE+ P P T PQ P P P + P S
Sbjct: 1452 LLEEKPPPTPPP--------------APTPQPQPPPPPPPPQPALPSPPPLVAPTPSSPP 1497
Query: 1120 QPP 1122
PP
Sbjct: 1498 PPP 1500
Score = 30.8 bits (68), Expect = 8.4
Identities = 19/59 (32%), Positives = 23/59 (38%), Gaps = 14/59 (23%)
Query: 418 ASTPPP----PPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPP 472
+S PPP PPP P P + PP P TA P PP P ++ P
Sbjct: 1689 SSAPPPKAPAPPPKPETPEKTTSEKPPEQTP----------ETAMPEPPAPEKPSLLRP 1737
>gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]
Length = 502
Score = 90.9 bits (224), Expect = 7e-18
Identities = 60/161 (37%), Positives = 71/161 (44%), Gaps = 22/161 (13%)
Query: 415 EQQASTPPPPPPPPLLPGSSAEPPP--------PPPPPPLPSVGAKALPTAPPPPPLPGL 466
E + P PPPPPP G+ PP P PP+P +G P P PP PG
Sbjct: 306 EMRRQEPLPPPPPPSRGGNQLPRPPIVGGNKGRSGPLPPVP-LGIAPPPPTPRGPPPPGR 364
Query: 467 GAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLP----GMGWGPPPPPPPLL 522
G PP PPP G LPPPPP G PPPPPP P G G PPP PP L+
Sbjct: 365 GGPPPP----PPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPALV 420
Query: 523 PCTCSPPVAGGMEEVIVAQVDHGL---GSAWVPSHRRVNPP 560
P P GG ++ Q+ G+ + P + PP
Sbjct: 421 PAGGLAP--GGGRGALLDQIRQGIQLNKTPGAPESSALQPP 459
Score = 61.6 bits (148), Expect = 4e-09
Identities = 36/106 (33%), Positives = 43/106 (40%), Gaps = 17/106 (16%)
Query: 379 PKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQASTP----PPPPPPPLLPGSS 434
P+P + G + PV L ++ P + P PPPPPPP S
Sbjct: 327 PRPPIVGGNKGRSGPLPPVP-------LGIAPPPPTPRGPPPPGRGGPPPPPPPATGRSG 379
Query: 435 AEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPL 480
PPPP P G +P PPPPP P P PPLPP L
Sbjct: 380 PLPPPP------PGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPAL 419
Score = 44.7 bits (104), Expect = 6e-04
Identities = 39/124 (31%), Positives = 45/124 (36%), Gaps = 23/124 (18%)
Query: 348 PRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILK 407
PRP P+V +K L G +P P P+ G P P
Sbjct: 327 PRP-PIVGGNKGRSGPLPPVPLGIAP-----PPPTPRGPPPPGRGGPPP----------- 369
Query: 408 VSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLG 467
P A + PPPPP P PPPPPP PS G P P PP L G
Sbjct: 370 -PPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPP----PSSGNGPAP-PPLPPALVPAG 423
Query: 468 AMAP 471
+AP
Sbjct: 424 GLAP 427
>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
1 [Homo sapiens]
Length = 1250
Score = 89.7 bits (221), Expect = 2e-17
Identities = 86/303 (28%), Positives = 116/303 (38%), Gaps = 55/303 (18%)
Query: 348 PRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILK 407
P P P + A QA +P +T T P V Q A PV A+ +
Sbjct: 763 PPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVT--QAAPPTPTPPVPPAKKQPAFP 820
Query: 408 VSQPRALEQQASTPPPPPPPPLLPG--SSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPG 465
S + TPP P PPP LP S PPP P P+PSV + PPPP P
Sbjct: 821 ASY---IPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPA 877
Query: 466 LGAM------APPAPPLPPPLPGSCEFLP----------PPPPPLPGLGCPPPPPPLLPG 509
+ + A AP PP + ++ P PPPPP L PPPPP +P
Sbjct: 878 MESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVP- 936
Query: 510 MGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNW 569
PPPPPPP T SP GS + + +P
Sbjct: 937 ---APPPPPPP----TASP-------------TPDKSGSPGKKTSKTSSP---------G 967
Query: 570 QKLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPA--AKPKEPTMVAPRARKEP 627
K P + ++S+ +S + E P S+ F+ PA P + T+ P A +P
Sbjct: 968 GKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKP 1027
Query: 628 KEI 630
++
Sbjct: 1028 GKL 1030
Score = 86.7 bits (213), Expect = 1e-16
Identities = 58/166 (34%), Positives = 67/166 (40%), Gaps = 48/166 (28%)
Query: 407 KVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTA--------- 457
K+ P Q + PPPPPPP P PPPPPPPPPLPS A + +A
Sbjct: 614 KIVTPYTASQPSPPLPPPPPPPPPP----PPPPPPPPPPLPSQSAPSAGSAAPMFVKYST 669
Query: 458 ----------------PPPPP------------LPGLGAMAPPAPPLPPPLPGS--CEFL 487
PP PP +P G + PP PP PPP PGS +
Sbjct: 670 ITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLK 729
Query: 488 PPP-PPPLPGLGCPPPPPPLLP----GMGWGPPPPPPPLLPCTCSP 528
P P P LP PPPP + P PPPPP +P P
Sbjct: 730 PAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPP 775
Score = 78.2 bits (191), Expect = 5e-14
Identities = 84/299 (28%), Positives = 110/299 (36%), Gaps = 56/299 (18%)
Query: 350 PSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQ-----QPAAAAACEPVDHAQSES 404
P+P V +SV+ + G P P P G +PA A P A
Sbjct: 687 PTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPP 746
Query: 405 ILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLP 464
LK+ Q + + Q A PP PPPPP +P P PP PP P V A + P+
Sbjct: 747 -LKIHQVQHITQVA--PPTPPPPPPIPA-----PLPPQAPPKPLVTIPAPTSTKTVAPVV 798
Query: 465 GLGAMAPPAPPLPPP-----LPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPP 519
A P PP+PP P S ++PP PP P P PPP L + PPP
Sbjct: 799 TQAAPPTPTPPVPPAKKQPAFPAS--YIPPSPPTPP---VPVPPPTLPKQQSFCAKPPPS 853
Query: 520 PLLPCTC----------SPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNW 569
PL P PP ME + V + +PP ++ K W
Sbjct: 854 PLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQ--------SPPAVKAKP-KW 904
Query: 570 QKLPSNVAREHNSMWASLSSPDAEAVEPDFSSI---ERLFSFPAAKPKEPTMVAPRARK 625
Q PS++ + SPD P+ S + PA P P +P K
Sbjct: 905 Q--PSSI---------PVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDK 952
Score = 72.0 bits (175), Expect = 3e-12
Identities = 62/221 (28%), Positives = 78/221 (35%), Gaps = 74/221 (33%)
Query: 370 GSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESI--------------LKVSQPRALE 415
GSS + + + Q + + +P H +S+SI L+ S +E
Sbjct: 537 GSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKARME 596
Query: 416 QQ-----ASTPPPPPPPPLL-------PGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPL 463
+ PP P P ++ P PPPPPPPPP P P PPPPPL
Sbjct: 597 SMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPP-------PPPPPPPPL 649
Query: 464 PGLGA-----------------------------MAPPAPPLPPPLPGSCEFLPPP---- 490
P A PP PP+ + L PP
Sbjct: 650 PSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVV 709
Query: 491 PPPLPGLGCPPPPPPLLPG--MGWGPPPPPPPLLPCTCSPP 529
PPP PPPPPP PG M P P P LP +PP
Sbjct: 710 PPP------PPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPP 744
Score = 58.2 bits (139), Expect = 5e-08
Identities = 78/303 (25%), Positives = 97/303 (32%), Gaps = 91/303 (30%)
Query: 347 RPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESIL 406
+P PSPL V+ Q P T P + +P A QS +
Sbjct: 849 KPPPSPLSPVPSVVKQIASQF-----PPPPTPPAMESQPLKPVPANVAP-----QSPPAV 898
Query: 407 KVS---QPRALEQQASTPPPPPP------PPLLPGSSAEPPPPPPPPPLP------SVGA 451
K QP ++ + PPPPP PP P PPPPPPP P S G
Sbjct: 899 KAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGK 958
Query: 452 KALPTAPP----PPPLPG------------------------LGAMAPPA---------- 473
K T+ P PPP P + PPA
Sbjct: 959 KTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETL 1018
Query: 474 -PPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWG--------------PPPPP 518
PP PP PG P + GC P+L G G PPPPP
Sbjct: 1019 PPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPP 1078
Query: 519 PPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAR 578
LP PP+ + V G S P VNP + K++ +K P
Sbjct: 1079 ETELPL---PPIE-------IPAVFSGNTS---PKVAVVNPQPQQWSKMSVKKAPPPTRP 1125
Query: 579 EHN 581
+ N
Sbjct: 1126 KRN 1128
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 89.7 bits (221), Expect = 2e-17
Identities = 68/205 (33%), Positives = 83/205 (40%), Gaps = 35/205 (17%)
Query: 346 GRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESI 405
G P P+ L+ V +L + T T + EGQQ + D S I
Sbjct: 599 GPPDPAGLLSQTAEVALDLVGDR-------TPTSEKMDEGQQSSGEDMEISDDEMPSAPI 651
Query: 406 LKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPG 465
P+ + P L P + PPPP PPLP P PPPPP PG
Sbjct: 652 TSADCPKPMVVTPGAAAVAAPSVLAP--TLPLPPPPGFPPLP-------PPPPPPPPQPG 702
Query: 466 LGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCT 525
M PP PP P PPPPP P + PPPP P PG+ PPPP+LP
Sbjct: 703 F-PMPPPLPPPP----------PPPPPAHPAVTVPPPPLPAPPGV------PPPPILPPL 745
Query: 526 CSPPVAGGMEEVIVAQVDHGLGSAW 550
PP G+ V+ + H LG W
Sbjct: 746 --PPFPPGLFPVMQVDMSHVLGGQW 768
Score = 55.1 bits (131), Expect = 4e-07
Identities = 45/138 (32%), Positives = 54/138 (39%), Gaps = 34/138 (24%)
Query: 406 LKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPP---------PPPLPSVGAKALPT 456
L ++ P L QA P P PP LLP A PPP PP + S+ +
Sbjct: 1439 LPLALPAVLRAQARAPTPLPP--LLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGPLV-- 1494
Query: 457 APPPPPLPGLGAMAPPAPPLPPPLPGSCE-----------FLPPPPPPLPGLGCPPPPPP 505
PP G + P P P P + + +P PPPPLP PPPPPP
Sbjct: 1495 RPPAGAALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQ--PPPPPP 1552
Query: 506 LLPGMGWGPPPPPPPLLP 523
PPP P LP
Sbjct: 1553 --------PPPVEPTKLP 1562
Score = 54.7 bits (130), Expect = 5e-07
Identities = 54/189 (28%), Positives = 68/189 (35%), Gaps = 38/189 (20%)
Query: 367 SQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQASTPPPPPP 426
SQ G+ + P VE + P + P + + ++ P L P PPP
Sbjct: 1232 SQEGAMLLSPEPPAKEVEARPPLS-----PERAPEHDLEVEPEPPMMLPLPLQPPLPPPR 1286
Query: 427 PPLLPGSSAEPPPPPPPPPLPSVGAKALPTAP----PPPPLPGL-GAMA--------PPA 473
PP PP PPP P ++P P PP PGL G++A P
Sbjct: 1287 PP-------RPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTETVPAT 1339
Query: 474 PPLPPPLPGSCEFLPPPPPPLPG--LGCPPPPP-------PLLPGMGWGPPP----PPPP 520
P PPL G L P +PG P P P P PG + P P P
Sbjct: 1340 PGGEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPSLSSGGLPRTPGRDFSFTPTFSEPSGP 1399
Query: 521 LLPCTCSPP 529
LL C P
Sbjct: 1400 LLLPVCPLP 1408
Score = 52.4 bits (124), Expect = 3e-06
Identities = 46/162 (28%), Positives = 58/162 (35%), Gaps = 18/162 (11%)
Query: 384 EGQQPAAAAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPP 443
+G++ A A VD E + + ++ + PP P+ A+ PP
Sbjct: 1169 DGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEE 1228
Query: 444 PPLPSVGAKALPTAPPP------PPL-----PGLGAMAPPAPPLPPPLPGSCEFLPPPPP 492
P L GA L PP PPL P P PP+ PLP PP PP
Sbjct: 1229 PGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLP----LQPPLPP 1284
Query: 493 PLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGM 534
P P PP PP P P PP PP G+
Sbjct: 1285 PRPPR---PPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGL 1323
Score = 51.6 bits (122), Expect = 5e-06
Identities = 44/135 (32%), Positives = 50/135 (37%), Gaps = 29/135 (21%)
Query: 409 SQPRALEQQASTPPPPPPPPLLPGSSAE-----------PPPPPPPPPLPSVGAK---AL 454
+QP+ A TPPP P PG + PPPP P + GA+
Sbjct: 370 AQPQDSATFAHTPPPAQATP-APGFKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSGEF 428
Query: 455 PTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGP 514
AP PPPL PPA PL PG+ PPP LG P GW P
Sbjct: 429 RRAPAPPPL-------PPAEPLAKEKPGTPPGPPPPDTNSMELGGRPT-------FGWSP 474
Query: 515 PPPPPPLLPCTCSPP 529
P P P S P
Sbjct: 475 EPCDSPGTPTLESSP 489
Score = 47.8 bits (112), Expect = 7e-05
Identities = 59/207 (28%), Positives = 73/207 (35%), Gaps = 48/207 (23%)
Query: 363 NLDQSQRGSSPQNTTTPKPSVEG----QQPAAAAACEPVDHAQSESILKVSQPRALEQQA 418
+L Q SP + P PS+ + P + P S +L P ++
Sbjct: 1354 SLSSPQVPGSPFSYPAPSPSLSSGGLPRTPGRDFSFTPTFSEPSGPLLLPVCPLPTGRRD 1413
Query: 419 STPPPPPPPPLLPGSSAEPPPPPPPPP--LPSV---GAKALPTAPP---------PPPL- 463
P P LL P P P P P LP+V A+A PP PPP+
Sbjct: 1414 ERSGPLASPVLLETGLPLPLPLPLPLPLALPAVLRAQARAPTPLPPLLPAPLASCPPPMK 1473
Query: 464 --PGLGAMAPPA----------PPLPPPLPGSCEFLP--PPPPPLP-------------G 496
PG +PP+ PP L LP P P P
Sbjct: 1474 RKPGRPRRSPPSMLSLDGPLVRPPAGAALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRN 1533
Query: 497 LGCPPPPPPLLPGMGWGPPPPPPPLLP 523
G P PPPPL P PPPPPPP+ P
Sbjct: 1534 AGIPAPPPPLPPQP--PPPPPPPPVEP 1558
Score = 39.7 bits (91), Expect = 0.018
Identities = 35/108 (32%), Positives = 36/108 (33%), Gaps = 25/108 (23%)
Query: 418 ASTPPPPPPPPLLPGSSAE--------PPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAM 469
A PPPP P A P PPP PP P AK P PP PP P +M
Sbjct: 405 AHFPPPPEEPTATAAFGARDSGEFRRAPAPPPLPPAEPL--AKEKPGTPPGPPPPDTNSM 462
Query: 470 APPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPP 517
L G F P P C P P L GP P
Sbjct: 463 ---------ELGGRPTFGWSPEP------CDSPGTPTLESSPAGPEKP 495
Score = 38.9 bits (89), Expect = 0.031
Identities = 32/105 (30%), Positives = 45/105 (42%), Gaps = 18/105 (17%)
Query: 350 PSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPV----DHAQSESI 405
P+PL ++ + +R S P + P V + PA AA + Q+
Sbjct: 1462 PAPLASCPPPMKRKPGRPRR-SPPSMLSLDGPLV--RPPAGAALGRELLLLPGQPQTPVF 1518
Query: 406 LKVSQPRALE---QQASTPPPPPP-PPLLPGSSAEPPPPPPPPPL 446
PR + + A P PPPP PP +PPPPPPPPP+
Sbjct: 1519 PSTHDPRTVTLDFRNAGIPAPPPPLPP-------QPPPPPPPPPV 1556
Score = 35.8 bits (81), Expect = 0.26
Identities = 35/117 (29%), Positives = 39/117 (33%), Gaps = 16/117 (13%)
Query: 419 STPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPP 478
S+ PP P + A PPP P P + P P P PP P
Sbjct: 363 SSGPPFKAQPQDSATFAHTPPPAQATPAPGFKSAFSPYQTPVAHFP-----PPPEEPTAT 417
Query: 479 PLPG---SCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAG 532
G S EF P PPP PP P P PP P P T S + G
Sbjct: 418 AAFGARDSGEFRRAP--------APPPLPPAEPLAKEKPGTPPGPPPPDTNSMELGG 466
Score = 33.5 bits (75), Expect = 1.3
Identities = 27/98 (27%), Positives = 36/98 (36%), Gaps = 5/98 (5%)
Query: 372 SPQNTTTPKPSVEGQQPAAAAACEPVD-----HAQSESILKVSQPRALEQQASTPPPPPP 426
SP T ++P A AA D A + L ++P A E+ + P PPPP
Sbjct: 398 SPYQTPVAHFPPPPEEPTATAAFGARDSGEFRRAPAPPPLPPAEPLAKEKPGTPPGPPPP 457
Query: 427 PPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLP 464
P P P S G L ++P P P
Sbjct: 458 DTNSMELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKP 495
>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
sapiens]
Length = 483
Score = 89.0 bits (219), Expect = 3e-17
Identities = 59/143 (41%), Positives = 63/143 (44%), Gaps = 32/143 (22%)
Query: 418 ASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLP--GLGAMAPPAPP 475
A T PP P P P + PPPPP PPPLPS P PP PL L +APP P
Sbjct: 162 ARTAPPRPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPC 221
Query: 476 LPPPLPGSCEFLPPPPPP------------LPGLGCP--PPPPPLLPGMGW--------- 512
PPP P PPP PP L L P PPP PLLP G+
Sbjct: 222 APPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPAS 281
Query: 513 ------GPPPPPPPLLP-CTCSP 528
PP PPPPL P +CSP
Sbjct: 282 PAQDAQEPPAPPPPLPPYASCSP 304
Score = 79.0 bits (193), Expect = 3e-14
Identities = 53/131 (40%), Positives = 59/131 (45%), Gaps = 28/131 (21%)
Query: 421 PPPPPPPPLLP-----GSSAEPP--------PPPPPPPLPSVGAKALPTAPPPPPLPGLG 467
PP PPP PLLP G AEP PP PPPPLP + + + P PPLPG+
Sbjct: 258 PPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVN 317
Query: 468 AMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPP---PLL-------PGMGWG---P 514
+ + PPLPP P PP L PP PP P L PG G G P
Sbjct: 318 SSSETPPPLPPKSPSF--QAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNP 375
Query: 515 PPPPPPLLPCT 525
PP PP P T
Sbjct: 376 PPAPPARSPTT 386
Score = 74.7 bits (182), Expect = 5e-13
Identities = 66/232 (28%), Positives = 79/232 (34%), Gaps = 81/232 (34%)
Query: 370 GSSPQNTTTPKPSVEGQQ-PAAAAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPP- 427
GS + P ++ G P A+ A + +P TPPPPPPP
Sbjct: 127 GSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPL 186
Query: 428 -PLLPGSS--------------------------AEPPPPPPPPPLPSVGAKALPTAPPP 460
P LP SS PPPPPPPPP P P
Sbjct: 187 PPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPP------------PTP 234
Query: 461 PPLPGLGAMAPPA----------PPLPPPLP------------------GSCEFLPPPPP 492
PPLP ++ A PP+PPPLP + P PPP
Sbjct: 235 PPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPP 294
Query: 493 PLPGLGC-------PPPPPPLLPGMGWG--PPPPPPPLLPCTCSPPVAGGME 535
PLP P PP LPG+ PPP PP P +PP G +
Sbjct: 295 PLPPYASCSPRASLPAPP---LPGVNSSSETPPPLPPKSPSFQAPPQKAGAQ 343
Score = 72.4 bits (176), Expect = 3e-12
Identities = 61/187 (32%), Positives = 71/187 (37%), Gaps = 40/187 (21%)
Query: 373 PQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPG 432
P P P + P+++ P+ + K + P PPPPPPPP
Sbjct: 176 PPTPPPPPPPLPPPLPSSSPIKTPLVSPPGP-LTKGNLPVVAPPVPCAPPPPPPPP---- 230
Query: 433 SSAEPPPPPPP-PPLPSVGAKA---------LPTAPPPPPL------PGL---------G 467
PP PPP PP + KA LP PPP PL PGL
Sbjct: 231 -----PPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQD 285
Query: 468 AMAPPAPPLPPPLPGSCE-FLPPPPPPLPGLG----CPPPPPPLLPGMGWGPPPPPPPLL 522
A PPAPP P P SC P PPLPG+ PPP PP P P L
Sbjct: 286 AQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQAL 345
Query: 523 PCTCSPP 529
P +PP
Sbjct: 346 PAPPAPP 352
Score = 47.0 bits (110), Expect = 1e-04
Identities = 22/36 (61%), Positives = 22/36 (61%), Gaps = 11/36 (30%)
Query: 488 PPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLP 523
PPPPPPLP PPPPPL G PPPPPP P
Sbjct: 5 PPPPPPLP-----PPPPPL------GAPPPPPPSAP 29
Score = 46.2 bits (108), Expect = 2e-04
Identities = 23/42 (54%), Positives = 23/42 (54%), Gaps = 13/42 (30%)
Query: 437 PPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPP 478
P PPPPPPPLP PPPPP LGA PP P PP
Sbjct: 2 PVPPPPPPPLP----------PPPPP---LGAPPPPPPSAPP 30
Score = 45.8 bits (107), Expect = 3e-04
Identities = 22/37 (59%), Positives = 22/37 (59%), Gaps = 9/37 (24%)
Query: 472 PAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLP 508
P PP PPP LPPPPPPL G PPPPPP P
Sbjct: 2 PVPPPPPPP------LPPPPPPL---GAPPPPPPSAP 29
Score = 43.1 bits (100), Expect = 0.002
Identities = 25/56 (44%), Positives = 26/56 (46%), Gaps = 26/56 (46%)
Query: 421 PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPL 476
P PPPPP PP PPPPPPL APPPPP P APP+
Sbjct: 2 PVPPPPP---------PPLPPPPPPL---------GAPPPPP--------PSAPPV 31
Score = 42.4 bits (98), Expect = 0.003
Identities = 19/39 (48%), Positives = 20/39 (51%)
Query: 421 PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPP 459
PPPPPP P P PPPPPP P S +L A P
Sbjct: 5 PPPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADP 43
Score = 34.3 bits (77), Expect = 0.76
Identities = 18/36 (50%), Positives = 20/36 (55%), Gaps = 12/36 (33%)
Query: 500 PPPPPPLLPGMGWGPPPPPPPL----LPCTCSPPVA 531
PPPPPPL PPPPPPL P +PPV+
Sbjct: 5 PPPPPPL--------PPPPPPLGAPPPPPPSAPPVS 32
>gi|162329583 cleavage and polyadenylation specific factor 6, 68 kD
subunit [Homo sapiens]
Length = 551
Score = 87.4 bits (215), Expect = 8e-17
Identities = 60/147 (40%), Positives = 63/147 (42%), Gaps = 36/147 (24%)
Query: 421 PPP------PPPPPLLPGSSAEPPPPPPPP---PLPSVGAKALPTAPPPPPL-PGLGAMA 470
PPP PP PPL P PP PPPP P P G PPPP L PG
Sbjct: 227 PPPFPAGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQ 286
Query: 471 PPAPPL----PPPLPGSCEFLPPPPPPLPGLGCPPP-------------------PPPLL 507
PP PL PPP+PG + PPP PP P G PPP PPP L
Sbjct: 287 PPLGPLPPGPPPPVPG---YGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHL 343
Query: 508 PGMGWGPPPPPPPLLPCTCSPPVAGGM 534
PG G PPP P + P PP GM
Sbjct: 344 PGPPPGAPPPAPHVNPAFFPPPTNSGM 370
Score = 75.5 bits (184), Expect = 3e-13
Identities = 51/127 (40%), Positives = 55/127 (43%), Gaps = 23/127 (18%)
Query: 424 PPPPPLLPGSS-AEPP----PPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPP 478
PPPP L PG +PP PP PPPP+P G P PPPP G P PP PP
Sbjct: 273 PPPPVLFPGQPFGQPPLGPLPPGPPPPVPGYG----PPPGPPPPQQGPPPPPGPFPPRPP 328
Query: 479 -PLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPP-----------PPPLLPCTC 526
PL PPP P P G PPP P + P + PPP PPP P
Sbjct: 329 GPLGPPLTLAPPPHLPGPPPGAPPPAPHVNP--AFFPPPTNSGMPTSDSRGPPPTDPYGR 386
Query: 527 SPPVAGG 533
PP G
Sbjct: 387 PPPYDRG 393
Score = 73.6 bits (179), Expect = 1e-12
Identities = 48/109 (44%), Positives = 51/109 (46%), Gaps = 17/109 (15%)
Query: 427 PPLLPGSSAEPPPPPP---PPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGS 483
P +PG P P P PPP P A PP P LG PP PP PPP PG
Sbjct: 208 PGAVPGGDRFPGPAGPGGPPPPFP---------AGQTPPRPPLGPPGPPGPPGPPP-PG- 256
Query: 484 CEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAG 532
+ LPPP P G PPPP L PG +G PP P LP PPV G
Sbjct: 257 -QVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGP--LPPGPPPPVPG 302
Score = 51.2 bits (121), Expect = 6e-06
Identities = 38/100 (38%), Positives = 39/100 (39%), Gaps = 36/100 (36%)
Query: 416 QQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPP 475
QQ PPP P PP PP P PPL T PPP LPG P P
Sbjct: 313 QQGPPPPPGPFPP--------RPPGPLGPPL---------TLAPPPHLPG------PPPG 349
Query: 476 LPPPLPG-SCEFLPPP------------PPPLPGLGCPPP 502
PPP P + F PPP PPP G PPP
Sbjct: 350 APPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPP 389
>gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]
Length = 639
Score = 87.4 bits (215), Expect = 8e-17
Identities = 63/180 (35%), Positives = 77/180 (42%), Gaps = 41/180 (22%)
Query: 379 PKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQASTPPPP----PPPPLLPGSS 434
P P +G P P+D + + R + + PPPP PPPP P S
Sbjct: 429 PPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPP--PPPS 486
Query: 435 AEPPPPPPPPPLPSVGAKALPTAPPPP--------PLP------------GLGAMAP--- 471
+PPPPP P P + P PPPP PLP G G++ P
Sbjct: 487 GQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQ 546
Query: 472 -----PAPPLPPPLPGSCEFLPPPP---PPLPGLGCPPPPPPLLPG---MGWGPPPPPPP 520
A P P + G+ +P PP PPLP G PPPPPP PG M + PPPPPPP
Sbjct: 547 QQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPP-GAPPPPPPPPPGSAGMMYAPPPPPPP 605
Score = 79.3 bits (194), Expect = 2e-14
Identities = 52/150 (34%), Positives = 60/150 (40%), Gaps = 52/150 (34%)
Query: 421 PPPPPPPPLLPGSSAEPPPPPPPPP---------LP----------SVGAKALP------ 455
PPPPP PL P + PPPPPPP LP S G ++P
Sbjct: 489 PPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQ 548
Query: 456 ----TAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGC------PPPPPP 505
+P P + G M P P + PPLP PPPPPP PG PPPPPP
Sbjct: 549 AAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAP--PPPPPPPPGSAGMMYAPPPPPPPP 606
Query: 506 L---------------LPGMGWGPPPPPPP 520
+ +P G P PPPPP
Sbjct: 607 MDPSNFVTMMGMGVAGMPPFGMPPAPPPPP 636
Score = 67.4 bits (163), Expect = 8e-11
Identities = 45/129 (34%), Positives = 53/129 (41%), Gaps = 27/129 (20%)
Query: 374 QNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQASTP-PPPPPPPLLPG 432
QNTTT S A + P Q+ + P+ P PP PPL PG
Sbjct: 527 QNTTTTTTS------AGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPG 580
Query: 433 SSAEPPPPPPPPPLPSVGAKALPTAPPPPPLP--------GLGAMAPPAPPLPPPLPGSC 484
+ PPPPPPPP S G P PPPPP+ G+G P +PP
Sbjct: 581 A----PPPPPPPPPGSAGMMYAPPPPPPPPMDPSNFVTMMGMGVAGMPPFGMPP------ 630
Query: 485 EFLPPPPPP 493
PPPPPP
Sbjct: 631 --APPPPPP 637
Score = 57.4 bits (137), Expect = 8e-08
Identities = 41/125 (32%), Positives = 52/125 (41%), Gaps = 25/125 (20%)
Query: 414 LEQQASTPPPP----PPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAM 469
++ + PPPP PPPP+ G PP PPP+ P G+ +
Sbjct: 413 MQHNPNGPPPPWMQPPPPPMNQGP--HPPGHHGPPPMDQYLGST-------PVGSGVYRL 463
Query: 470 APPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWG------PPPPPPPLLP 523
+PPP G +PPPPPP G PPPPP P W PPPPPP
Sbjct: 464 HQGKGMMPPPPMG---MMPPPPPPPSG---QPPPPPSGPLPPWQQQQQQPPPPPPPSSSM 517
Query: 524 CTCSP 528
+ +P
Sbjct: 518 ASSTP 522
Score = 55.5 bits (132), Expect = 3e-07
Identities = 56/209 (26%), Positives = 70/209 (33%), Gaps = 83/209 (39%)
Query: 396 PVDHAQSESILKVSQPRALEQQASTPPPPPPPP-LLPGSSAEPP---------------- 438
PV + + + P A + + P PPPP L+ + + PP
Sbjct: 324 PVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMH 383
Query: 439 ----------PPPPPPPLPSV----GAKAL---PTAPPPPPLPGLGAMAPPAPPL----- 476
P P PLPS+ G + P PPPP M PP PP+
Sbjct: 384 GGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPP------WMQPPPPPMNQGPH 437
Query: 477 ------PPPL------------------------PGSCEFLPPPPPPLPGLGCPPPPPPL 506
PPP+ P +PPPPPP G PPPPP
Sbjct: 438 PPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSG---QPPPPPS 494
Query: 507 LPGMGW-----GPPPPPPPLLPCTCSPPV 530
P W PPPPPPP S P+
Sbjct: 495 GPLPPWQQQQQQPPPPPPPSSSMASSTPL 523
Score = 46.6 bits (109), Expect = 1e-04
Identities = 56/204 (27%), Positives = 76/204 (37%), Gaps = 45/204 (22%)
Query: 355 KAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRAL 414
K + S+ A L ++ +S +T+ P + P AA P ++ S++ +Q R
Sbjct: 311 KEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAA---PANNPPPPSLMSTTQSRPP 367
Query: 415 EQQASTPPPPPPPPLLPGSSAEPPPPPP--PPPLPSV----GAKAL---PTAPPPPPLPG 465
+ P + G P P P PLPS+ G + P PPPP
Sbjct: 368 WMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPP---- 423
Query: 466 LGAMAPPAPPLP--PPLPGSCEFLPPPPPPLPGLGCPP---------------PPPPLLP 508
M PP PP+ P PG PPP LG P PPPP+
Sbjct: 424 --WMQPPPPPMNQGPHPPGH----HGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPM-- 475
Query: 509 GMGWGPPPPPPPLLPCTCSPPVAG 532
G PPPPP PP +G
Sbjct: 476 ----GMMPPPPPPPSGQPPPPPSG 495
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,196,928
Number of Sequences: 37866
Number of extensions: 4257220
Number of successful extensions: 114634
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1245
Number of HSP's successfully gapped in prelim test: 1879
Number of HSP's that attempted gapping in prelim test: 27341
Number of HSP's gapped (non-prelim): 29664
length of query: 1240
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1126
effective length of database: 13,930,794
effective search space: 15686074044
effective search space used: 15686074044
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.