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Search of human proteins with 14916473
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14916473 scinderin isoform 2 [Homo sapiens]
(468 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|162951877 scinderin isoform 1 [Homo sapiens] 954 0.0
gi|14916473 scinderin isoform 2 [Homo sapiens] 954 0.0
gi|4504165 gelsolin isoform a precursor [Homo sapiens] 601 e-172
gi|38044288 gelsolin isoform b [Homo sapiens] 601 e-172
gi|189083782 gelsolin isoform c [Homo sapiens] 601 e-172
gi|189083780 gelsolin isoform c [Homo sapiens] 601 e-172
gi|189083778 gelsolin isoform b [Homo sapiens] 601 e-172
gi|189083776 gelsolin isoform b [Homo sapiens] 601 e-172
gi|189083774 gelsolin isoform b [Homo sapiens] 601 e-172
gi|189083772 gelsolin isoform b [Homo sapiens] 601 e-172
gi|194394237 villin 1 [Homo sapiens] 469 e-132
gi|17572824 advillin [Homo sapiens] 453 e-127
gi|94721268 villin-like protein [Homo sapiens] 340 1e-93
gi|4503743 flightless I homolog [Homo sapiens] 170 3e-42
gi|63252913 gelsolin-like capping protein [Homo sapiens] 129 4e-30
gi|150417973 supervillin isoform 2 [Homo sapiens] 106 4e-23
gi|150417971 supervillin isoform 1 [Homo sapiens] 106 4e-23
gi|41872646 cullin 7 [Homo sapiens] 31 2.1
gi|14589951 DNA directed RNA polymerase II polypeptide E [Homo s... 30 6.1
gi|4759344 centromere/kinetochore protein zw10 [Homo sapiens] 30 6.1
>gi|162951877 scinderin isoform 1 [Homo sapiens]
Length = 715
Score = 954 bits (2466), Expect = 0.0
Identities = 468/468 (100%), Positives = 468/468 (100%)
Query: 1 MAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERK 60
MAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERK
Sbjct: 248 MAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERK 307
Query: 61 AAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQ 120
AAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQ
Sbjct: 308 AAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQ 367
Query: 121 IKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYII 180
IKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYII
Sbjct: 368 IKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYII 427
Query: 181 LYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFK 240
LYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFK
Sbjct: 428 LYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFK 487
Query: 241 DKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQ 300
DKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQ
Sbjct: 488 DKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQ 547
Query: 301 NSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLET 360
NSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLET
Sbjct: 548 NSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLET 607
Query: 361 QAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEK 420
QAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEK
Sbjct: 608 QAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEK 667
Query: 421 KESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 468
KESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW
Sbjct: 668 KESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 715
Score = 132 bits (333), Expect = 5e-31
Identities = 101/338 (29%), Positives = 162/338 (47%), Gaps = 34/338 (10%)
Query: 151 VEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYPRGQ----IIYTWQGANATRDELTTS 206
+++WR+E + V Q+++G+FY GD Y++L+T + ++ W G ++DE T +
Sbjct: 19 LQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTAKTSRGFTYHLHFWLGKECSQDESTAA 78
Query: 207 AFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQ----APAPP 262
A TVQ+D LGG+ VQ R QG E +S FK + YK G G
Sbjct: 79 AIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKGG--LKYKAGGVASGLNHVLTNDLTA 136
Query: 263 TRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYV 322
RL V+ + R EV + +S N D F++ L Y W G ++ E A V
Sbjct: 137 KRLLHVKGR--RVVRATEVPLSWDSFNKGDCFIIDLGTEI-YQWCGSSCNKYERLKANQV 193
Query: 323 ASVL-------KCKTLRIQEGEEPEEFWNSLGGKKDY----QTSPLLETQAEDHPPRLYG 371
A+ + + + + ++EG EP E LG K + ++ + +LY
Sbjct: 194 ATGIRYNERKGRSELIVVEEGSEPSELIKVLGEKPELPDGGDDDDIIADISNRKMAKLYM 253
Query: 372 CSNKTGRF----VIEEIPGEFTQDDLAEDDVMLLD--AWEQIFIWIGKDANEVEKKESLK 425
S+ +G V EE P F+ L ++ +LD A +QIF+W GKDAN E+K ++K
Sbjct: 254 VSDASGSMRVTVVAEENP--FSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMK 311
Query: 426 SAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGW 463
+A+ +L+ K T I ++ +G E P F +F W
Sbjct: 312 TAEEFLQ--QMNYSKNTQIQVLPEGGETPIFKQFFKDW 347
Score = 45.1 bits (105), Expect = 1e-04
Identities = 99/490 (20%), Positives = 179/490 (36%), Gaps = 93/490 (18%)
Query: 15 RVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMN 74
R V A E P S +CFI+D G +I+ W G N ER A + A + N
Sbjct: 145 RRVVRATEVPLSWDSFNKGDCFIIDLGT--EIYQWCGSSCNKYERLKANQVATGI--RYN 200
Query: 75 YSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSS 134
K ++ E G P + K +K + G + +A I S
Sbjct: 201 ERKGRSELIVVEEGSEP--SELIKVLGEKPELPDGGD--DDDIIADI------------S 244
Query: 135 PQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYPRGQIIYTWQ 194
+ A+ MV D SG + + V S +C+I+ + + I+ W+
Sbjct: 245 NRKMAKLYMVSDASGSMRVTVVAEENPF-----SMAMLLSEECFIL--DHGAAKQIFVWK 297
Query: 195 GANATRDE----LTTSAFLTVQLDRSLGGQAVQIRVSQGKEPV--HLLSLFKDKPLI--- 245
G +A E + T+ Q++ S Q +Q+ G+ P+ ++DK
Sbjct: 298 GKDANPQERKAAMKTAEEFLQQMNYSKNTQ-IQVLPEGGETPIFKQFFKDWRDKDQSDGF 356
Query: 246 --IYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVE---------------VDVDANSL 288
+Y + Q P ++L + A + + + VD NS
Sbjct: 357 GKVYVTEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSY 416
Query: 289 N---SNDVFVLKLPQNSG---YIWVGKGASQEEEKGAEYVASVL------KCKTLRIQEG 336
D +++ G Y W G A+++E + ++ L + +R+ +G
Sbjct: 417 GEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQG 476
Query: 337 EEPEEFWNSLGGKKDYQTSPLL---------ETQAEDHPPRLYGCSNKTGRFVIEEIPGE 387
+EP + ++ PL+ QA P RL+ + + +
Sbjct: 477 KEPVHLLSL------FKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLAS-ITRIVEVD 529
Query: 388 FTQDDLAEDDVMLLDAWEQI-FIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTPIVI 446
+ L +DV +L + +IW+GK A++ E+K + A + + +
Sbjct: 530 VDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVASVL----------KCKTLR 579
Query: 447 IKQGHEPPTF 456
I++G EP F
Sbjct: 580 IQEGEEPEEF 589
>gi|14916473 scinderin isoform 2 [Homo sapiens]
Length = 468
Score = 954 bits (2466), Expect = 0.0
Identities = 468/468 (100%), Positives = 468/468 (100%)
Query: 1 MAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERK 60
MAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERK
Sbjct: 1 MAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERK 60
Query: 61 AAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQ 120
AAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQ
Sbjct: 61 AAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQ 120
Query: 121 IKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYII 180
IKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYII
Sbjct: 121 IKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYII 180
Query: 181 LYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFK 240
LYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFK
Sbjct: 181 LYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFK 240
Query: 241 DKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQ 300
DKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQ
Sbjct: 241 DKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQ 300
Query: 301 NSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLET 360
NSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLET
Sbjct: 301 NSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLET 360
Query: 361 QAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEK 420
QAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEK
Sbjct: 361 QAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEK 420
Query: 421 KESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 468
KESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW
Sbjct: 421 KESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 468
>gi|4504165 gelsolin isoform a precursor [Homo sapiens]
Length = 782
Score = 601 bits (1549), Expect = e-172
Identities = 281/473 (59%), Positives = 360/473 (76%), Gaps = 6/473 (1%)
Query: 1 MAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERK 60
+AKLY VS+ +G+M V++VA+ENPF+ L SE+CFILDHG +IFVWKGK AN +ERK
Sbjct: 297 LAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERK 356
Query: 61 AAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQ 120
AA+KTA +F+ +M+Y K TQ+ VLPEGGETP+FKQFFK+WRD DQ+DG G Y++ +A
Sbjct: 357 AALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIAN 416
Query: 121 IKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYII 180
++++PFDA+ LH+S MAAQH M DDG+G+ +IWR+E + ++ VD +YG+FYGGD YII
Sbjct: 417 VERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYII 476
Query: 181 LYTY----PRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLL 236
LY Y +GQIIY WQGA +T+DE+ SA LT QLD LGG VQ RV QGKEP HL+
Sbjct: 477 LYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLM 536
Query: 237 SLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVL 296
SLF KP+IIYK GTS++GGQ TRLFQVR N A TR VEV A +LNSND FVL
Sbjct: 537 SLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVL 596
Query: 297 KLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSP 356
K P ++ Y+WVG GAS+ E+ GA+ + VL+ + +++ EG EP+ FW +LGGK Y+TSP
Sbjct: 597 KTP-SAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSP 655
Query: 357 LLETQAED-HPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDA 415
L+ + D HPPRL+ CSNK GRFVIEE+PGE Q+DLA DDVMLLD W+Q+F+W+GKD+
Sbjct: 656 RLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDS 715
Query: 416 NEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 468
E EK E+L SAK Y+ETDP+ RD+RTPI ++KQG EPP+F GWFLGWD W
Sbjct: 716 QEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYW 768
Score = 135 bits (340), Expect = 8e-32
Identities = 110/337 (32%), Positives = 155/337 (45%), Gaps = 32/337 (9%)
Query: 151 VEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYP--RGQIIYT---WQGANATRDELTT 205
++IWRVE + V N YG+F+ GD Y+IL T G + Y W G ++DE
Sbjct: 68 LQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGA 127
Query: 206 SAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAP---- 261
+A TVQLD L G+AVQ R QG E L FK + YK G G + P
Sbjct: 128 AAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSG--LKYKKGGVASGFKHVVPNEVV 185
Query: 262 PTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEY 321
RLFQV+ + R EV V S N+ D F+L L N + W G +++ E A
Sbjct: 186 VQRLFQVKGR--RVVRATEVPVSWESFNNGDCFILDLGNNI-HQWCGSNSNRYERLKATQ 242
Query: 322 VASVL-------KCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDHPPR----LY 370
V+ + + + +EG EPE LG K +T ED R LY
Sbjct: 243 VSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAG-TEDTAKEDAANRKLAKLY 301
Query: 371 GCSNKTGRFVIEEIPGE--FTQDDLAEDDVMLLDAWE--QIFIWIGKDANEVEKKESLKS 426
SN G + + E F Q L +D +LD + +IF+W GK AN E+K +LK+
Sbjct: 302 KVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALKT 361
Query: 427 AKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGW 463
A ++ K+T + ++ +G E P F +F W
Sbjct: 362 ASDFI--TKMDYPKQTQVSVLPEGGETPLFKQFFKNW 396
Score = 37.0 bits (84), Expect = 0.038
Identities = 47/203 (23%), Positives = 79/203 (38%), Gaps = 37/203 (18%)
Query: 15 RVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMN 74
R V A E P S + +CFILD G I W G ++N ER A + ++ ++
Sbjct: 195 RRVVRATEVPVSWESFNNGDCFILDLG--NNIHQWCGSNSNRYERLKATQVSKG-IRDNE 251
Query: 75 YSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSS 134
S ++ V EG E Q V + D +K ++
Sbjct: 252 RSGRARVHVSEEGTEPEAMLQ------------------VLGPKPALPAGTEDTAKEDAA 293
Query: 135 PQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSY--GEFYGGDCYIILYTYPRGQIIYT 192
+ A+ V +G+G + + + D+N + G DC+I+ + + I+
Sbjct: 294 NRKLAKLYKVSNGAGTMSV-------SLVADENPFAQGALKSEDCFIL--DHGKDGKIFV 344
Query: 193 WQGANATRDE-----LTTSAFLT 210
W+G A +E T S F+T
Sbjct: 345 WKGKQANTEERKAALKTASDFIT 367
>gi|38044288 gelsolin isoform b [Homo sapiens]
Length = 731
Score = 601 bits (1549), Expect = e-172
Identities = 281/473 (59%), Positives = 360/473 (76%), Gaps = 6/473 (1%)
Query: 1 MAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERK 60
+AKLY VS+ +G+M V++VA+ENPF+ L SE+CFILDHG +IFVWKGK AN +ERK
Sbjct: 246 LAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERK 305
Query: 61 AAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQ 120
AA+KTA +F+ +M+Y K TQ+ VLPEGGETP+FKQFFK+WRD DQ+DG G Y++ +A
Sbjct: 306 AALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIAN 365
Query: 121 IKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYII 180
++++PFDA+ LH+S MAAQH M DDG+G+ +IWR+E + ++ VD +YG+FYGGD YII
Sbjct: 366 VERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYII 425
Query: 181 LYTY----PRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLL 236
LY Y +GQIIY WQGA +T+DE+ SA LT QLD LGG VQ RV QGKEP HL+
Sbjct: 426 LYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLM 485
Query: 237 SLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVL 296
SLF KP+IIYK GTS++GGQ TRLFQVR N A TR VEV A +LNSND FVL
Sbjct: 486 SLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVL 545
Query: 297 KLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSP 356
K P ++ Y+WVG GAS+ E+ GA+ + VL+ + +++ EG EP+ FW +LGGK Y+TSP
Sbjct: 546 KTP-SAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSP 604
Query: 357 LLETQAED-HPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDA 415
L+ + D HPPRL+ CSNK GRFVIEE+PGE Q+DLA DDVMLLD W+Q+F+W+GKD+
Sbjct: 605 RLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDS 664
Query: 416 NEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 468
E EK E+L SAK Y+ETDP+ RD+RTPI ++KQG EPP+F GWFLGWD W
Sbjct: 665 QEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYW 717
Score = 135 bits (340), Expect = 8e-32
Identities = 110/337 (32%), Positives = 155/337 (45%), Gaps = 32/337 (9%)
Query: 151 VEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYP--RGQIIYT---WQGANATRDELTT 205
++IWRVE + V N YG+F+ GD Y+IL T G + Y W G ++DE
Sbjct: 17 LQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGA 76
Query: 206 SAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAP---- 261
+A TVQLD L G+AVQ R QG E L FK + YK G G + P
Sbjct: 77 AAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSG--LKYKKGGVASGFKHVVPNEVV 134
Query: 262 PTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEY 321
RLFQV+ + R EV V S N+ D F+L L N + W G +++ E A
Sbjct: 135 VQRLFQVKGR--RVVRATEVPVSWESFNNGDCFILDLGNNI-HQWCGSNSNRYERLKATQ 191
Query: 322 VASVL-------KCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDHPPR----LY 370
V+ + + + +EG EPE LG K +T ED R LY
Sbjct: 192 VSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAG-TEDTAKEDAANRKLAKLY 250
Query: 371 GCSNKTGRFVIEEIPGE--FTQDDLAEDDVMLLDAWE--QIFIWIGKDANEVEKKESLKS 426
SN G + + E F Q L +D +LD + +IF+W GK AN E+K +LK+
Sbjct: 251 KVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALKT 310
Query: 427 AKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGW 463
A ++ K+T + ++ +G E P F +F W
Sbjct: 311 ASDFI--TKMDYPKQTQVSVLPEGGETPLFKQFFKNW 345
Score = 37.0 bits (84), Expect = 0.038
Identities = 47/203 (23%), Positives = 79/203 (38%), Gaps = 37/203 (18%)
Query: 15 RVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMN 74
R V A E P S + +CFILD G I W G ++N ER A + ++ ++
Sbjct: 144 RRVVRATEVPVSWESFNNGDCFILDLG--NNIHQWCGSNSNRYERLKATQVSKG-IRDNE 200
Query: 75 YSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSS 134
S ++ V EG E Q V + D +K ++
Sbjct: 201 RSGRARVHVSEEGTEPEAMLQ------------------VLGPKPALPAGTEDTAKEDAA 242
Query: 135 PQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSY--GEFYGGDCYIILYTYPRGQIIYT 192
+ A+ V +G+G + + + D+N + G DC+I+ + + I+
Sbjct: 243 NRKLAKLYKVSNGAGTMSV-------SLVADENPFAQGALKSEDCFIL--DHGKDGKIFV 293
Query: 193 WQGANATRDE-----LTTSAFLT 210
W+G A +E T S F+T
Sbjct: 294 WKGKQANTEERKAALKTASDFIT 316
>gi|189083782 gelsolin isoform c [Homo sapiens]
Length = 742
Score = 601 bits (1549), Expect = e-172
Identities = 281/473 (59%), Positives = 360/473 (76%), Gaps = 6/473 (1%)
Query: 1 MAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERK 60
+AKLY VS+ +G+M V++VA+ENPF+ L SE+CFILDHG +IFVWKGK AN +ERK
Sbjct: 257 LAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERK 316
Query: 61 AAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQ 120
AA+KTA +F+ +M+Y K TQ+ VLPEGGETP+FKQFFK+WRD DQ+DG G Y++ +A
Sbjct: 317 AALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIAN 376
Query: 121 IKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYII 180
++++PFDA+ LH+S MAAQH M DDG+G+ +IWR+E + ++ VD +YG+FYGGD YII
Sbjct: 377 VERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYII 436
Query: 181 LYTY----PRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLL 236
LY Y +GQIIY WQGA +T+DE+ SA LT QLD LGG VQ RV QGKEP HL+
Sbjct: 437 LYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLM 496
Query: 237 SLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVL 296
SLF KP+IIYK GTS++GGQ TRLFQVR N A TR VEV A +LNSND FVL
Sbjct: 497 SLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVL 556
Query: 297 KLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSP 356
K P ++ Y+WVG GAS+ E+ GA+ + VL+ + +++ EG EP+ FW +LGGK Y+TSP
Sbjct: 557 KTP-SAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSP 615
Query: 357 LLETQAED-HPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDA 415
L+ + D HPPRL+ CSNK GRFVIEE+PGE Q+DLA DDVMLLD W+Q+F+W+GKD+
Sbjct: 616 RLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDS 675
Query: 416 NEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 468
E EK E+L SAK Y+ETDP+ RD+RTPI ++KQG EPP+F GWFLGWD W
Sbjct: 676 QEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYW 728
Score = 135 bits (340), Expect = 8e-32
Identities = 110/337 (32%), Positives = 155/337 (45%), Gaps = 32/337 (9%)
Query: 151 VEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYP--RGQIIYT---WQGANATRDELTT 205
++IWRVE + V N YG+F+ GD Y+IL T G + Y W G ++DE
Sbjct: 28 LQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGA 87
Query: 206 SAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAP---- 261
+A TVQLD L G+AVQ R QG E L FK + YK G G + P
Sbjct: 88 AAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSG--LKYKKGGVASGFKHVVPNEVV 145
Query: 262 PTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEY 321
RLFQV+ + R EV V S N+ D F+L L N + W G +++ E A
Sbjct: 146 VQRLFQVKGR--RVVRATEVPVSWESFNNGDCFILDLGNNI-HQWCGSNSNRYERLKATQ 202
Query: 322 VASVL-------KCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDHPPR----LY 370
V+ + + + +EG EPE LG K +T ED R LY
Sbjct: 203 VSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAG-TEDTAKEDAANRKLAKLY 261
Query: 371 GCSNKTGRFVIEEIPGE--FTQDDLAEDDVMLLDAWE--QIFIWIGKDANEVEKKESLKS 426
SN G + + E F Q L +D +LD + +IF+W GK AN E+K +LK+
Sbjct: 262 KVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALKT 321
Query: 427 AKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGW 463
A ++ K+T + ++ +G E P F +F W
Sbjct: 322 ASDFI--TKMDYPKQTQVSVLPEGGETPLFKQFFKNW 356
Score = 37.0 bits (84), Expect = 0.038
Identities = 47/203 (23%), Positives = 79/203 (38%), Gaps = 37/203 (18%)
Query: 15 RVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMN 74
R V A E P S + +CFILD G I W G ++N ER A + ++ ++
Sbjct: 155 RRVVRATEVPVSWESFNNGDCFILDLG--NNIHQWCGSNSNRYERLKATQVSKG-IRDNE 211
Query: 75 YSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSS 134
S ++ V EG E Q V + D +K ++
Sbjct: 212 RSGRARVHVSEEGTEPEAMLQ------------------VLGPKPALPAGTEDTAKEDAA 253
Query: 135 PQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSY--GEFYGGDCYIILYTYPRGQIIYT 192
+ A+ V +G+G + + + D+N + G DC+I+ + + I+
Sbjct: 254 NRKLAKLYKVSNGAGTMSV-------SLVADENPFAQGALKSEDCFIL--DHGKDGKIFV 304
Query: 193 WQGANATRDE-----LTTSAFLT 210
W+G A +E T S F+T
Sbjct: 305 WKGKQANTEERKAALKTASDFIT 327
>gi|189083780 gelsolin isoform c [Homo sapiens]
Length = 742
Score = 601 bits (1549), Expect = e-172
Identities = 281/473 (59%), Positives = 360/473 (76%), Gaps = 6/473 (1%)
Query: 1 MAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERK 60
+AKLY VS+ +G+M V++VA+ENPF+ L SE+CFILDHG +IFVWKGK AN +ERK
Sbjct: 257 LAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERK 316
Query: 61 AAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQ 120
AA+KTA +F+ +M+Y K TQ+ VLPEGGETP+FKQFFK+WRD DQ+DG G Y++ +A
Sbjct: 317 AALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIAN 376
Query: 121 IKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYII 180
++++PFDA+ LH+S MAAQH M DDG+G+ +IWR+E + ++ VD +YG+FYGGD YII
Sbjct: 377 VERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYII 436
Query: 181 LYTY----PRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLL 236
LY Y +GQIIY WQGA +T+DE+ SA LT QLD LGG VQ RV QGKEP HL+
Sbjct: 437 LYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLM 496
Query: 237 SLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVL 296
SLF KP+IIYK GTS++GGQ TRLFQVR N A TR VEV A +LNSND FVL
Sbjct: 497 SLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVL 556
Query: 297 KLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSP 356
K P ++ Y+WVG GAS+ E+ GA+ + VL+ + +++ EG EP+ FW +LGGK Y+TSP
Sbjct: 557 KTP-SAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSP 615
Query: 357 LLETQAED-HPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDA 415
L+ + D HPPRL+ CSNK GRFVIEE+PGE Q+DLA DDVMLLD W+Q+F+W+GKD+
Sbjct: 616 RLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDS 675
Query: 416 NEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 468
E EK E+L SAK Y+ETDP+ RD+RTPI ++KQG EPP+F GWFLGWD W
Sbjct: 676 QEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYW 728
Score = 135 bits (340), Expect = 8e-32
Identities = 110/337 (32%), Positives = 155/337 (45%), Gaps = 32/337 (9%)
Query: 151 VEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYP--RGQIIYT---WQGANATRDELTT 205
++IWRVE + V N YG+F+ GD Y+IL T G + Y W G ++DE
Sbjct: 28 LQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGA 87
Query: 206 SAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAP---- 261
+A TVQLD L G+AVQ R QG E L FK + YK G G + P
Sbjct: 88 AAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSG--LKYKKGGVASGFKHVVPNEVV 145
Query: 262 PTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEY 321
RLFQV+ + R EV V S N+ D F+L L N + W G +++ E A
Sbjct: 146 VQRLFQVKGR--RVVRATEVPVSWESFNNGDCFILDLGNNI-HQWCGSNSNRYERLKATQ 202
Query: 322 VASVL-------KCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDHPPR----LY 370
V+ + + + +EG EPE LG K +T ED R LY
Sbjct: 203 VSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAG-TEDTAKEDAANRKLAKLY 261
Query: 371 GCSNKTGRFVIEEIPGE--FTQDDLAEDDVMLLDAWE--QIFIWIGKDANEVEKKESLKS 426
SN G + + E F Q L +D +LD + +IF+W GK AN E+K +LK+
Sbjct: 262 KVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALKT 321
Query: 427 AKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGW 463
A ++ K+T + ++ +G E P F +F W
Sbjct: 322 ASDFI--TKMDYPKQTQVSVLPEGGETPLFKQFFKNW 356
Score = 37.0 bits (84), Expect = 0.038
Identities = 47/203 (23%), Positives = 79/203 (38%), Gaps = 37/203 (18%)
Query: 15 RVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMN 74
R V A E P S + +CFILD G I W G ++N ER A + ++ ++
Sbjct: 155 RRVVRATEVPVSWESFNNGDCFILDLG--NNIHQWCGSNSNRYERLKATQVSKG-IRDNE 211
Query: 75 YSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSS 134
S ++ V EG E Q V + D +K ++
Sbjct: 212 RSGRARVHVSEEGTEPEAMLQ------------------VLGPKPALPAGTEDTAKEDAA 253
Query: 135 PQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSY--GEFYGGDCYIILYTYPRGQIIYT 192
+ A+ V +G+G + + + D+N + G DC+I+ + + I+
Sbjct: 254 NRKLAKLYKVSNGAGTMSV-------SLVADENPFAQGALKSEDCFIL--DHGKDGKIFV 304
Query: 193 WQGANATRDE-----LTTSAFLT 210
W+G A +E T S F+T
Sbjct: 305 WKGKQANTEERKAALKTASDFIT 327
>gi|189083778 gelsolin isoform b [Homo sapiens]
Length = 731
Score = 601 bits (1549), Expect = e-172
Identities = 281/473 (59%), Positives = 360/473 (76%), Gaps = 6/473 (1%)
Query: 1 MAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERK 60
+AKLY VS+ +G+M V++VA+ENPF+ L SE+CFILDHG +IFVWKGK AN +ERK
Sbjct: 246 LAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERK 305
Query: 61 AAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQ 120
AA+KTA +F+ +M+Y K TQ+ VLPEGGETP+FKQFFK+WRD DQ+DG G Y++ +A
Sbjct: 306 AALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIAN 365
Query: 121 IKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYII 180
++++PFDA+ LH+S MAAQH M DDG+G+ +IWR+E + ++ VD +YG+FYGGD YII
Sbjct: 366 VERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYII 425
Query: 181 LYTY----PRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLL 236
LY Y +GQIIY WQGA +T+DE+ SA LT QLD LGG VQ RV QGKEP HL+
Sbjct: 426 LYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLM 485
Query: 237 SLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVL 296
SLF KP+IIYK GTS++GGQ TRLFQVR N A TR VEV A +LNSND FVL
Sbjct: 486 SLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVL 545
Query: 297 KLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSP 356
K P ++ Y+WVG GAS+ E+ GA+ + VL+ + +++ EG EP+ FW +LGGK Y+TSP
Sbjct: 546 KTP-SAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSP 604
Query: 357 LLETQAED-HPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDA 415
L+ + D HPPRL+ CSNK GRFVIEE+PGE Q+DLA DDVMLLD W+Q+F+W+GKD+
Sbjct: 605 RLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDS 664
Query: 416 NEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 468
E EK E+L SAK Y+ETDP+ RD+RTPI ++KQG EPP+F GWFLGWD W
Sbjct: 665 QEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYW 717
Score = 135 bits (340), Expect = 8e-32
Identities = 110/337 (32%), Positives = 155/337 (45%), Gaps = 32/337 (9%)
Query: 151 VEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYP--RGQIIYT---WQGANATRDELTT 205
++IWRVE + V N YG+F+ GD Y+IL T G + Y W G ++DE
Sbjct: 17 LQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGA 76
Query: 206 SAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAP---- 261
+A TVQLD L G+AVQ R QG E L FK + YK G G + P
Sbjct: 77 AAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSG--LKYKKGGVASGFKHVVPNEVV 134
Query: 262 PTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEY 321
RLFQV+ + R EV V S N+ D F+L L N + W G +++ E A
Sbjct: 135 VQRLFQVKGR--RVVRATEVPVSWESFNNGDCFILDLGNNI-HQWCGSNSNRYERLKATQ 191
Query: 322 VASVL-------KCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDHPPR----LY 370
V+ + + + +EG EPE LG K +T ED R LY
Sbjct: 192 VSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAG-TEDTAKEDAANRKLAKLY 250
Query: 371 GCSNKTGRFVIEEIPGE--FTQDDLAEDDVMLLDAWE--QIFIWIGKDANEVEKKESLKS 426
SN G + + E F Q L +D +LD + +IF+W GK AN E+K +LK+
Sbjct: 251 KVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALKT 310
Query: 427 AKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGW 463
A ++ K+T + ++ +G E P F +F W
Sbjct: 311 ASDFI--TKMDYPKQTQVSVLPEGGETPLFKQFFKNW 345
Score = 37.0 bits (84), Expect = 0.038
Identities = 47/203 (23%), Positives = 79/203 (38%), Gaps = 37/203 (18%)
Query: 15 RVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMN 74
R V A E P S + +CFILD G I W G ++N ER A + ++ ++
Sbjct: 144 RRVVRATEVPVSWESFNNGDCFILDLG--NNIHQWCGSNSNRYERLKATQVSKG-IRDNE 200
Query: 75 YSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSS 134
S ++ V EG E Q V + D +K ++
Sbjct: 201 RSGRARVHVSEEGTEPEAMLQ------------------VLGPKPALPAGTEDTAKEDAA 242
Query: 135 PQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSY--GEFYGGDCYIILYTYPRGQIIYT 192
+ A+ V +G+G + + + D+N + G DC+I+ + + I+
Sbjct: 243 NRKLAKLYKVSNGAGTMSV-------SLVADENPFAQGALKSEDCFIL--DHGKDGKIFV 293
Query: 193 WQGANATRDE-----LTTSAFLT 210
W+G A +E T S F+T
Sbjct: 294 WKGKQANTEERKAALKTASDFIT 316
>gi|189083776 gelsolin isoform b [Homo sapiens]
Length = 731
Score = 601 bits (1549), Expect = e-172
Identities = 281/473 (59%), Positives = 360/473 (76%), Gaps = 6/473 (1%)
Query: 1 MAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERK 60
+AKLY VS+ +G+M V++VA+ENPF+ L SE+CFILDHG +IFVWKGK AN +ERK
Sbjct: 246 LAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERK 305
Query: 61 AAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQ 120
AA+KTA +F+ +M+Y K TQ+ VLPEGGETP+FKQFFK+WRD DQ+DG G Y++ +A
Sbjct: 306 AALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIAN 365
Query: 121 IKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYII 180
++++PFDA+ LH+S MAAQH M DDG+G+ +IWR+E + ++ VD +YG+FYGGD YII
Sbjct: 366 VERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYII 425
Query: 181 LYTY----PRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLL 236
LY Y +GQIIY WQGA +T+DE+ SA LT QLD LGG VQ RV QGKEP HL+
Sbjct: 426 LYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLM 485
Query: 237 SLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVL 296
SLF KP+IIYK GTS++GGQ TRLFQVR N A TR VEV A +LNSND FVL
Sbjct: 486 SLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVL 545
Query: 297 KLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSP 356
K P ++ Y+WVG GAS+ E+ GA+ + VL+ + +++ EG EP+ FW +LGGK Y+TSP
Sbjct: 546 KTP-SAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSP 604
Query: 357 LLETQAED-HPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDA 415
L+ + D HPPRL+ CSNK GRFVIEE+PGE Q+DLA DDVMLLD W+Q+F+W+GKD+
Sbjct: 605 RLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDS 664
Query: 416 NEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 468
E EK E+L SAK Y+ETDP+ RD+RTPI ++KQG EPP+F GWFLGWD W
Sbjct: 665 QEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYW 717
Score = 135 bits (340), Expect = 8e-32
Identities = 110/337 (32%), Positives = 155/337 (45%), Gaps = 32/337 (9%)
Query: 151 VEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYP--RGQIIYT---WQGANATRDELTT 205
++IWRVE + V N YG+F+ GD Y+IL T G + Y W G ++DE
Sbjct: 17 LQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGA 76
Query: 206 SAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAP---- 261
+A TVQLD L G+AVQ R QG E L FK + YK G G + P
Sbjct: 77 AAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSG--LKYKKGGVASGFKHVVPNEVV 134
Query: 262 PTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEY 321
RLFQV+ + R EV V S N+ D F+L L N + W G +++ E A
Sbjct: 135 VQRLFQVKGR--RVVRATEVPVSWESFNNGDCFILDLGNNI-HQWCGSNSNRYERLKATQ 191
Query: 322 VASVL-------KCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDHPPR----LY 370
V+ + + + +EG EPE LG K +T ED R LY
Sbjct: 192 VSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAG-TEDTAKEDAANRKLAKLY 250
Query: 371 GCSNKTGRFVIEEIPGE--FTQDDLAEDDVMLLDAWE--QIFIWIGKDANEVEKKESLKS 426
SN G + + E F Q L +D +LD + +IF+W GK AN E+K +LK+
Sbjct: 251 KVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALKT 310
Query: 427 AKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGW 463
A ++ K+T + ++ +G E P F +F W
Sbjct: 311 ASDFI--TKMDYPKQTQVSVLPEGGETPLFKQFFKNW 345
Score = 37.0 bits (84), Expect = 0.038
Identities = 47/203 (23%), Positives = 79/203 (38%), Gaps = 37/203 (18%)
Query: 15 RVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMN 74
R V A E P S + +CFILD G I W G ++N ER A + ++ ++
Sbjct: 144 RRVVRATEVPVSWESFNNGDCFILDLG--NNIHQWCGSNSNRYERLKATQVSKG-IRDNE 200
Query: 75 YSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSS 134
S ++ V EG E Q V + D +K ++
Sbjct: 201 RSGRARVHVSEEGTEPEAMLQ------------------VLGPKPALPAGTEDTAKEDAA 242
Query: 135 PQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSY--GEFYGGDCYIILYTYPRGQIIYT 192
+ A+ V +G+G + + + D+N + G DC+I+ + + I+
Sbjct: 243 NRKLAKLYKVSNGAGTMSV-------SLVADENPFAQGALKSEDCFIL--DHGKDGKIFV 293
Query: 193 WQGANATRDE-----LTTSAFLT 210
W+G A +E T S F+T
Sbjct: 294 WKGKQANTEERKAALKTASDFIT 316
>gi|189083774 gelsolin isoform b [Homo sapiens]
Length = 731
Score = 601 bits (1549), Expect = e-172
Identities = 281/473 (59%), Positives = 360/473 (76%), Gaps = 6/473 (1%)
Query: 1 MAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERK 60
+AKLY VS+ +G+M V++VA+ENPF+ L SE+CFILDHG +IFVWKGK AN +ERK
Sbjct: 246 LAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERK 305
Query: 61 AAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQ 120
AA+KTA +F+ +M+Y K TQ+ VLPEGGETP+FKQFFK+WRD DQ+DG G Y++ +A
Sbjct: 306 AALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIAN 365
Query: 121 IKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYII 180
++++PFDA+ LH+S MAAQH M DDG+G+ +IWR+E + ++ VD +YG+FYGGD YII
Sbjct: 366 VERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYII 425
Query: 181 LYTY----PRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLL 236
LY Y +GQIIY WQGA +T+DE+ SA LT QLD LGG VQ RV QGKEP HL+
Sbjct: 426 LYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLM 485
Query: 237 SLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVL 296
SLF KP+IIYK GTS++GGQ TRLFQVR N A TR VEV A +LNSND FVL
Sbjct: 486 SLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVL 545
Query: 297 KLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSP 356
K P ++ Y+WVG GAS+ E+ GA+ + VL+ + +++ EG EP+ FW +LGGK Y+TSP
Sbjct: 546 KTP-SAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSP 604
Query: 357 LLETQAED-HPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDA 415
L+ + D HPPRL+ CSNK GRFVIEE+PGE Q+DLA DDVMLLD W+Q+F+W+GKD+
Sbjct: 605 RLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDS 664
Query: 416 NEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 468
E EK E+L SAK Y+ETDP+ RD+RTPI ++KQG EPP+F GWFLGWD W
Sbjct: 665 QEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYW 717
Score = 135 bits (340), Expect = 8e-32
Identities = 110/337 (32%), Positives = 155/337 (45%), Gaps = 32/337 (9%)
Query: 151 VEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYP--RGQIIYT---WQGANATRDELTT 205
++IWRVE + V N YG+F+ GD Y+IL T G + Y W G ++DE
Sbjct: 17 LQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGA 76
Query: 206 SAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAP---- 261
+A TVQLD L G+AVQ R QG E L FK + YK G G + P
Sbjct: 77 AAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSG--LKYKKGGVASGFKHVVPNEVV 134
Query: 262 PTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEY 321
RLFQV+ + R EV V S N+ D F+L L N + W G +++ E A
Sbjct: 135 VQRLFQVKGR--RVVRATEVPVSWESFNNGDCFILDLGNNI-HQWCGSNSNRYERLKATQ 191
Query: 322 VASVL-------KCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDHPPR----LY 370
V+ + + + +EG EPE LG K +T ED R LY
Sbjct: 192 VSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAG-TEDTAKEDAANRKLAKLY 250
Query: 371 GCSNKTGRFVIEEIPGE--FTQDDLAEDDVMLLDAWE--QIFIWIGKDANEVEKKESLKS 426
SN G + + E F Q L +D +LD + +IF+W GK AN E+K +LK+
Sbjct: 251 KVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALKT 310
Query: 427 AKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGW 463
A ++ K+T + ++ +G E P F +F W
Sbjct: 311 ASDFI--TKMDYPKQTQVSVLPEGGETPLFKQFFKNW 345
Score = 37.0 bits (84), Expect = 0.038
Identities = 47/203 (23%), Positives = 79/203 (38%), Gaps = 37/203 (18%)
Query: 15 RVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMN 74
R V A E P S + +CFILD G I W G ++N ER A + ++ ++
Sbjct: 144 RRVVRATEVPVSWESFNNGDCFILDLG--NNIHQWCGSNSNRYERLKATQVSKG-IRDNE 200
Query: 75 YSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSS 134
S ++ V EG E Q V + D +K ++
Sbjct: 201 RSGRARVHVSEEGTEPEAMLQ------------------VLGPKPALPAGTEDTAKEDAA 242
Query: 135 PQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSY--GEFYGGDCYIILYTYPRGQIIYT 192
+ A+ V +G+G + + + D+N + G DC+I+ + + I+
Sbjct: 243 NRKLAKLYKVSNGAGTMSV-------SLVADENPFAQGALKSEDCFIL--DHGKDGKIFV 293
Query: 193 WQGANATRDE-----LTTSAFLT 210
W+G A +E T S F+T
Sbjct: 294 WKGKQANTEERKAALKTASDFIT 316
>gi|189083772 gelsolin isoform b [Homo sapiens]
Length = 731
Score = 601 bits (1549), Expect = e-172
Identities = 281/473 (59%), Positives = 360/473 (76%), Gaps = 6/473 (1%)
Query: 1 MAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERK 60
+AKLY VS+ +G+M V++VA+ENPF+ L SE+CFILDHG +IFVWKGK AN +ERK
Sbjct: 246 LAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERK 305
Query: 61 AAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQ 120
AA+KTA +F+ +M+Y K TQ+ VLPEGGETP+FKQFFK+WRD DQ+DG G Y++ +A
Sbjct: 306 AALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIAN 365
Query: 121 IKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYII 180
++++PFDA+ LH+S MAAQH M DDG+G+ +IWR+E + ++ VD +YG+FYGGD YII
Sbjct: 366 VERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYII 425
Query: 181 LYTY----PRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLL 236
LY Y +GQIIY WQGA +T+DE+ SA LT QLD LGG VQ RV QGKEP HL+
Sbjct: 426 LYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLM 485
Query: 237 SLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVL 296
SLF KP+IIYK GTS++GGQ TRLFQVR N A TR VEV A +LNSND FVL
Sbjct: 486 SLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVL 545
Query: 297 KLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSP 356
K P ++ Y+WVG GAS+ E+ GA+ + VL+ + +++ EG EP+ FW +LGGK Y+TSP
Sbjct: 546 KTP-SAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSP 604
Query: 357 LLETQAED-HPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDA 415
L+ + D HPPRL+ CSNK GRFVIEE+PGE Q+DLA DDVMLLD W+Q+F+W+GKD+
Sbjct: 605 RLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDS 664
Query: 416 NEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 468
E EK E+L SAK Y+ETDP+ RD+RTPI ++KQG EPP+F GWFLGWD W
Sbjct: 665 QEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYW 717
Score = 135 bits (340), Expect = 8e-32
Identities = 110/337 (32%), Positives = 155/337 (45%), Gaps = 32/337 (9%)
Query: 151 VEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYP--RGQIIYT---WQGANATRDELTT 205
++IWRVE + V N YG+F+ GD Y+IL T G + Y W G ++DE
Sbjct: 17 LQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGA 76
Query: 206 SAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAP---- 261
+A TVQLD L G+AVQ R QG E L FK + YK G G + P
Sbjct: 77 AAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSG--LKYKKGGVASGFKHVVPNEVV 134
Query: 262 PTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEY 321
RLFQV+ + R EV V S N+ D F+L L N + W G +++ E A
Sbjct: 135 VQRLFQVKGR--RVVRATEVPVSWESFNNGDCFILDLGNNI-HQWCGSNSNRYERLKATQ 191
Query: 322 VASVL-------KCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDHPPR----LY 370
V+ + + + +EG EPE LG K +T ED R LY
Sbjct: 192 VSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAG-TEDTAKEDAANRKLAKLY 250
Query: 371 GCSNKTGRFVIEEIPGE--FTQDDLAEDDVMLLDAWE--QIFIWIGKDANEVEKKESLKS 426
SN G + + E F Q L +D +LD + +IF+W GK AN E+K +LK+
Sbjct: 251 KVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALKT 310
Query: 427 AKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGW 463
A ++ K+T + ++ +G E P F +F W
Sbjct: 311 ASDFI--TKMDYPKQTQVSVLPEGGETPLFKQFFKNW 345
Score = 37.0 bits (84), Expect = 0.038
Identities = 47/203 (23%), Positives = 79/203 (38%), Gaps = 37/203 (18%)
Query: 15 RVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMN 74
R V A E P S + +CFILD G I W G ++N ER A + ++ ++
Sbjct: 144 RRVVRATEVPVSWESFNNGDCFILDLG--NNIHQWCGSNSNRYERLKATQVSKG-IRDNE 200
Query: 75 YSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSS 134
S ++ V EG E Q V + D +K ++
Sbjct: 201 RSGRARVHVSEEGTEPEAMLQ------------------VLGPKPALPAGTEDTAKEDAA 242
Query: 135 PQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSY--GEFYGGDCYIILYTYPRGQIIYT 192
+ A+ V +G+G + + + D+N + G DC+I+ + + I+
Sbjct: 243 NRKLAKLYKVSNGAGTMSV-------SLVADENPFAQGALKSEDCFIL--DHGKDGKIFV 293
Query: 193 WQGANATRDE-----LTTSAFLT 210
W+G A +E T S F+T
Sbjct: 294 WKGKQANTEERKAALKTASDFIT 316
>gi|194394237 villin 1 [Homo sapiens]
Length = 827
Score = 469 bits (1207), Expect = e-132
Identities = 233/471 (49%), Positives = 318/471 (67%), Gaps = 10/471 (2%)
Query: 3 KLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAA 62
KLY VSD+ G++ V VA P + +L E+C+ILD G K I+VWKGK AN QE+K A
Sbjct: 254 KLYHVSDSEGNLVVREVATR-PLTQDLLSHEDCYILDQGGLK-IYVWKGKKANEQEKKGA 311
Query: 63 MKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIK 122
M A F++ Y +TQ++V +G E+ +F+Q F+ W +++ G GK + VA+++
Sbjct: 312 MSHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGKTHTVGSVAKVE 371
Query: 123 QIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILY 182
Q+ FDA+ +H PQ+AAQ MVDDGSG+V++WR+EN + VD G FYGGDCY++LY
Sbjct: 372 QVKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLY 431
Query: 183 TYPRGQ----IIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSL 238
TY G+ ++Y WQG+ A++DE+T SA+ V LD+ G+ VQIRV GKEP HL+S+
Sbjct: 432 TYLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSI 491
Query: 239 FKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKL 298
FK + +++Y+ GTS+ P TRLFQV+ A+ T+ EV AN LNSNDVFVLK
Sbjct: 492 FKGR-MVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLK- 549
Query: 299 PQNSGYIWVGKGASQEEEKGAEYVA-SVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPL 357
Q+ Y+W GKG S +E + A+ VA ++ + + + EG+EP FW +LGGK Y +
Sbjct: 550 TQSCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKR 609
Query: 358 LETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANE 417
L+ + PRL+ CSNKTGRF+ EIP +F QDDL EDDV LLD W+Q+F WIGK ANE
Sbjct: 610 LQEENLVITPRLFECSNKTGRFLATEIP-DFNQDDLEEDDVFLLDVWDQVFFWIGKHANE 668
Query: 418 VEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 468
EKK + +A+ YL+T PSGRD TPI+++KQGHEPPTFTGWFL WD KW
Sbjct: 669 EEKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKW 719
Score = 101 bits (251), Expect = 2e-21
Identities = 102/361 (28%), Positives = 159/361 (44%), Gaps = 41/361 (11%)
Query: 134 SPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYPRGQI---- 189
S Q+ N+ G ++IWR+E + V +++G F+ GDCYIIL +
Sbjct: 5 SAQVKGSLNITTPG---LQIWRIEAMQMVPVPSSTFGSFFDGDCYIILAIHKTASSLSYD 61
Query: 190 IYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKN 249
I+ W G +++ DE +A T Q+D L G+AVQ R QG E FK + L+I K
Sbjct: 62 IHYWIGQDSSLDEQGAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFK-QGLVIRKG 120
Query: 250 GTS---KKGGQAPAPPTRLFQV--RRNLASITRIVEVDVDANSLNSNDVFVLKL------ 298
G + K RL V +RN+ + EV++ S N DVF+L L
Sbjct: 121 GVASGMKHVETNSYDVQRLLHVKGKRNVVA----GEVEMSWKSFNRGDVFLLDLGKLIIQ 176
Query: 299 ---PQNSGY-----IWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKK 350
P+++ + + K +E G YV V L + E N + GK+
Sbjct: 177 WNGPESTRMERLRGMTLAKEIRDQERGGRTYVGVVDGENEL---ASPKLMEVMNHVLGKR 233
Query: 351 DYQTSPLLETQAE---DHPPRLYGCSNKTGRFVIEEIPGE-FTQDDLAEDDVMLLD-AWE 405
+ + +T E +LY S+ G V+ E+ TQD L+ +D +LD
Sbjct: 234 RELKAAVPDTVVEPALKAALKLYHVSDSEGNLVVREVATRPLTQDLLSHEDCYILDQGGL 293
Query: 406 QIFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDS 465
+I++W GK ANE EKK ++ A +++ T + + G E F F W +
Sbjct: 294 KIYVWKGKKANEQEKKGAMSHALNFIKA--KQYPPSTQVEVQNDGAESAVFQQLFQKWTA 351
Query: 466 S 466
S
Sbjct: 352 S 352
>gi|17572824 advillin [Homo sapiens]
Length = 819
Score = 453 bits (1165), Expect = e-127
Identities = 229/470 (48%), Positives = 312/470 (66%), Gaps = 10/470 (2%)
Query: 4 LYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAM 63
LY +SD++G + VT VA P +L ++C+ILD K I+VWKGK A E++AAM
Sbjct: 252 LYHISDSAGQLAVTEVATR-PLVQDLLNHDDCYILDQSGTK-IYVWKGKGATKAEKQAAM 309
Query: 64 KTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQ 123
A F++ +Y +T ++ + +G E+ +FKQ F+ W KDQ+ G GK + K+A++ Q
Sbjct: 310 SKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFSIGKIAKVFQ 369
Query: 124 IPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILYT 183
FD + LH+ P++AAQ MVDDG+GKVE+WR+EN + V+ YG FYGGDCY++LYT
Sbjct: 370 DKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYGGDCYLVLYT 429
Query: 184 YPRG----QIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLF 239
Y I+Y WQG +A++DEL SA+ V++DR G AVQ+RV G EP H +++F
Sbjct: 430 YEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIF 489
Query: 240 KDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLP 299
K K L+I++ GTS+KG P PP RLFQ+ N S T+ VEV A+SLNSNDVF+L+
Sbjct: 490 KGK-LVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSNDVFLLR-T 547
Query: 300 QNSGYIWVGKGASQEEEKGAEYVASVL-KCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLL 358
Q Y+W GKG+S +E A+ +AS+L + EG+EP EFW+ LGGK Y L
Sbjct: 548 QAEHYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTPYANDKRL 607
Query: 359 ETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEV 418
+ + D RL+ CSNKTG+FV+ EI +FTQDDL DVMLLD W+Q+F+WIG +AN
Sbjct: 608 QQEILDVQSRLFECSNKTGQFVVTEIT-DFTQDDLNPTDVMLLDTWDQVFLWIGAEANAT 666
Query: 419 EKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 468
EK+ +L +A+ YL T PSGRD TPI+IIKQG EPP FTGWFL WD + W
Sbjct: 667 EKESALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIW 716
Score = 97.8 bits (242), Expect = 2e-20
Identities = 99/353 (28%), Positives = 151/353 (42%), Gaps = 49/353 (13%)
Query: 144 VDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYP----RGQIIYTWQGANAT 199
VD+ G + +WR+E V +++G FY GDCY+IL T Q I+ W G +++
Sbjct: 10 VDNDPGII-VWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIHFWIGKDSS 68
Query: 200 RDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAP 259
+DE + +A T QLD LGG VQ R Q E FK IIYK G G +
Sbjct: 69 QDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQG--IIYKQGGVASGMKHV 126
Query: 260 APPT----RLFQV--RRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQ 313
T RL V +RN+ R EV++ +S N DVF+L L + W G
Sbjct: 127 ETNTYDVKRLLHVKGKRNI----RATEVEMSWDSFNRGDVFLLDLGKVI-IQWNG----- 176
Query: 314 EEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLET------------- 360
E E + ++L K +R +E E + G K+ + L++
Sbjct: 177 PESNSGERLKAMLLAKDIRDRERGGRAEI-GVIEGDKEAASPELMKVLQDTLGRRSIIKP 235
Query: 361 --------QAEDHPPRLYGCSNKTGRFVIEEIPGE-FTQDDLAEDDVMLLD-AWEQIFIW 410
Q + LY S+ G+ + E+ QD L DD +LD + +I++W
Sbjct: 236 TVPDEIIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVW 295
Query: 411 IGKDANEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGW 463
GK A + EK+ ++ A +++ T + + G E F F W
Sbjct: 296 KGKGATKAEKQAAMSKALGFIKM--KSYPSSTNVETVNDGAESAMFKQLFQKW 346
>gi|94721268 villin-like protein [Homo sapiens]
Length = 856
Score = 340 bits (873), Expect = 1e-93
Identities = 188/471 (39%), Positives = 281/471 (59%), Gaps = 17/471 (3%)
Query: 3 KLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAA 62
+LY V + + V +A P + +L E+ +ILD G K I+VW+G+ ++ QERKAA
Sbjct: 252 RLYHVYEKGKDLVVLELATP-PLTQDLLQEEDFYILDQGGFK-IYVWQGRMSSLQERKAA 309
Query: 63 MKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIK 122
A F+Q Y T ++V+ +G E+ FKQ F+ W +K + + K+ +K +K
Sbjct: 310 FSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQ--KLGGRDKSIHVK 367
Query: 123 QIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILY 182
D KLH+ P++AAQ MVDDGSGKVE+W +++ R VD +G+ G+CY++LY
Sbjct: 368 ---LDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLY 424
Query: 183 TYPR----GQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSL 238
TY R I+Y WQG AT DE+ +LD GG VQ V+ G EP H L++
Sbjct: 425 TYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPHFLAI 484
Query: 239 FKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKL 298
F+ + L+I++ G A TRLFQV+ + TR +EV A+SLNS+D+F+L +
Sbjct: 485 FQGQ-LVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFLL-V 542
Query: 299 PQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLR-IQEGEEPEEFWNSLGGKKDYQTSPL 357
+ Y+W GKG + ++ + A V +V+ K + EG+EP FW +LGG+ Y ++
Sbjct: 543 TASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAPYPSNKR 602
Query: 358 LETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANE 417
L + PRL+ CS+ G V+ E+ G F+Q+DL + D+MLLD W++IF+W+G+ A+
Sbjct: 603 LPEEVPSFQPRLFECSSHMGCLVLAEV-GFFSQEDLDKYDIMLLDTWQEIFLWLGEAAS- 660
Query: 418 VEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 468
E KE++ + YL+T P+GR TPIV++KQGHEPPTF GWF WD KW
Sbjct: 661 -EWKEAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKW 710
Score = 77.8 bits (190), Expect = 2e-14
Identities = 91/355 (25%), Positives = 143/355 (40%), Gaps = 51/355 (14%)
Query: 149 GKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILY-------TYPRGQIIYTWQGANATRD 201
G + IW EN + V + +YG F+ CY+IL+ T ++ W G A +
Sbjct: 12 GGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQAGAE 71
Query: 202 ELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAP 261
+ +L LGGQ V R +QG E S F +P IIY +KGG A
Sbjct: 72 AQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYF--RPGIIY-----RKGGLA--- 121
Query: 262 PTRLFQVRRNLASITRIV-----------EVDVDANSLNSNDVFVLKLPQNSGYIWVGKG 310
+ L V NL +I R++ EV++ NS N D+F+L L + W G
Sbjct: 122 -SDLKHVETNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMM-IQWNGPK 179
Query: 311 ASQEEEKGAEYVASVLKCKTL---RIQEGEEPEE-------------FWNSLGGKKDYQT 354
S E+ + L+ + R Q G +E +G +
Sbjct: 180 TSISEKARGLALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATP 239
Query: 355 SPLLETQAEDHPPRLYGCSNKTGRFVIEEI-PGEFTQDDLAEDDVMLLD-AWEQIFIWIG 412
S + Q + RLY K V+ E+ TQD L E+D +LD +I++W G
Sbjct: 240 SKDI-NQLQKANVRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQG 298
Query: 413 KDANEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSK 467
+ ++ E+K + A +++ G T + ++ G E F F W +
Sbjct: 299 RMSSLQERKAAFSRAVGFIQA--KGYPTYTNVEVVNDGAESAAFKQLFRTWSEKR 351
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 170 bits (430), Expect = 3e-42
Identities = 146/509 (28%), Positives = 238/509 (46%), Gaps = 87/509 (17%)
Query: 30 LLSEEC-FILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGG 88
LL C +ILD +F+W G+ + R AA+K +E ++ ++ + EG
Sbjct: 769 LLDTRCVYILD--CWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGT 826
Query: 89 ETPIFKQFFKDWRDKD------------QSDGF-GKVYV-TEKVAQIKQ------IPFDA 128
E +FK FK+W D QS G GKV EK Q+K +P
Sbjct: 827 EAQVFKAKFKNWDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQP 886
Query: 129 S-KLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTY--- 184
L + Q+ + N DG +E + +E ++ + +G FY DCY+ L Y
Sbjct: 887 PMSLAEAEQLMEEWNEDLDG---MEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVP 943
Query: 185 ------------------PRGQ-----------------IIYTWQGANATRDELTTSAF- 208
G+ I+Y WQG A+ T F
Sbjct: 944 VEYEEEEKKEDKEEKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFS 1003
Query: 209 LTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQV 268
L + + G+ +R++Q +E LS FK K +I + +G Q P+ L+Q+
Sbjct: 1004 LQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPS----LYQI 1059
Query: 269 RRNLASI-TRIVEVDVDANSLNSNDVFVLKLP----QNSG--YIWVGKGASQEEEKGAEY 321
R N +++ TR ++++ D++ LNS F+LK+P N G Y WVG+ + +E K AE
Sbjct: 1060 RTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAED 1119
Query: 322 VASVLKCKTLR---IQEGEEPEEF-WNSLGGKKDYQTSPLLETQAEDHPPRLYGCSNKTG 377
+ + + + I EGEEPE F W +G +K Y + + H RL+ CSN+ G
Sbjct: 1120 ILNTMFDTSYSKQVINEGEEPENFFWVGIGAQKPYDD----DAEYMKHT-RLFRCSNEKG 1174
Query: 378 RFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSG 437
F + E +F QDDLA+DD+MLLD +++++W+G ++VE K SLK+ ++Y++ S
Sbjct: 1175 YFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSK 1234
Query: 438 RDKR-TPIVIIKQGHEPPTFTGWFLGWDS 465
+R + ++++G+E FT F W +
Sbjct: 1235 EHERPRRLRLVRKGNEQHAFTRCFHAWSA 1263
Score = 91.3 bits (225), Expect = 2e-18
Identities = 89/350 (25%), Positives = 145/350 (41%), Gaps = 51/350 (14%)
Query: 153 IWRVENNGRIQVDQNSYGEFYGGDCYIILYTY--PRGQI---IYTWQGANATRDELTTSA 207
IW++EN + V++ +G+FY DCYI+L T+ G + IY W G AT D+ SA
Sbjct: 503 IWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSA 562
Query: 208 FLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAPP---TR 264
V L LG + +R G E L +F + I Y G + G TR
Sbjct: 563 IHAVNLRNYLGAECRTVREEMGDESEEFLQVFDND--ISYIEGGTASGFYTVEDTHYVTR 620
Query: 265 LFQV--RRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYV 322
+++V ++N+ ++ V + SL+ VF+L + Y+W G A+ A
Sbjct: 621 MYRVYGKKNI----KLEPVPLKGTSLDPRFVFLLDRGLDI-YVWRGAQATLSSTTKARLF 675
Query: 323 ASVL-------KCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDH---PPRLYGC 372
A + K + + +G+E EFW +LGG + S + + ED P+LY
Sbjct: 676 AEKINKNERKGKAEITLLVQGQELPEFWEALGG----EPSEIKKHVPEDFWPPQPKLYKV 731
Query: 373 SNKTGRFVIEEIPGEFT------------------QDDLAEDDVMLLDAWEQIFIWIGKD 414
G + +I + + Q L V +LD W +FIW+G+
Sbjct: 732 GLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRK 791
Query: 415 ANEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWD 464
+ + + +LK + R + + +G E F F WD
Sbjct: 792 SPRLVRAAALKLGQEL--CGMLHRPRHATVSRSLEGTEAQVFKAKFKNWD 839
Score = 29.6 bits (65), Expect = 6.1
Identities = 32/98 (32%), Positives = 46/98 (46%), Gaps = 18/98 (18%)
Query: 4 LYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQ-----IFVWKGKDANPQE 58
LY + +GS T + N S ++L SE CFIL + ++ W G+ ++P E
Sbjct: 1056 LYQIR-TNGSALCTRCIQINTDS-SLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDE 1113
Query: 59 RKAAMKTAEEFLQQM---NYSKNTQIQVLPEGGETPIF 93
K AE+ L M +YSK QV+ EG E F
Sbjct: 1114 ----AKLAEDILNTMFDTSYSK----QVINEGEEPENF 1143
>gi|63252913 gelsolin-like capping protein [Homo sapiens]
Length = 348
Score = 129 bits (325), Expect = 4e-30
Identities = 53/100 (53%), Positives = 82/100 (82%)
Query: 2 AKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKA 61
A LY VSDA+G M +T VA+ +PF++ +L+S++CF+LD+G +I++WKG+ AN +ER+A
Sbjct: 249 AALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQA 308
Query: 62 AMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWR 101
A++ AE F+ +M Y+ NTQ+++LP+G E+PIFKQFFKDW+
Sbjct: 309 ALQVAEGFISRMQYAPNTQVEILPQGHESPIFKQFFKDWK 348
Score = 118 bits (295), Expect = 1e-26
Identities = 99/335 (29%), Positives = 155/335 (46%), Gaps = 30/335 (8%)
Query: 151 VEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYPRG-QIIYTWQGANATRDELTTSAFL 209
+ +WRVE + V Q + G F+ GD Y++L+ P ++ W G ++RDE A L
Sbjct: 21 LHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPEEVSHLHLWIGQQSSRDEQGACAVL 80
Query: 210 TVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTS----KKGGQAPAPPTRL 265
V L+ LG + VQ R QG E +S F + L + G K APA +L
Sbjct: 81 AVHLNTLLGERPVQHREVQGNESDLFMSYF-PRGLKYQEGGVESAFHKTSTGAPAAIKKL 139
Query: 266 FQV--RRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVA 323
+QV ++N+ + R + D S N+ D F+L L QN + W G ++ E A +A
Sbjct: 140 YQVKGKKNIRATERALNWD----SFNTGDCFILDLGQNI-FAWCGGKSNILERNKARDLA 194
Query: 324 SVL-------KCKTLRIQEGEEPEEFWNSLGG----KKDYQTSPLLETQAEDHPPRLYGC 372
+ K + + +GEEP E LG K+ L +A LY
Sbjct: 195 LAIRDSERQGKAQVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQAAALYKV 254
Query: 373 SNKTGRFVIEEI--PGEFTQDDLAEDDVMLLD--AWEQIFIWIGKDANEVEKKESLKSAK 428
S+ TG+ + ++ F + L DD +LD +I+IW G+ ANE E++ +L+ A+
Sbjct: 255 SDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVAE 314
Query: 429 MYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGW 463
++ T + I+ QGHE P F +F W
Sbjct: 315 GFISRMQYA--PNTQVEILPQGHESPIFKQFFKDW 347
>gi|150417973 supervillin isoform 2 [Homo sapiens]
Length = 2214
Score = 106 bits (265), Expect = 4e-23
Identities = 125/555 (22%), Positives = 229/555 (41%), Gaps = 136/555 (24%)
Query: 28 AMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEG 87
++L +E + D G+ +++VW GK+ +RK A + A+ +N I L G
Sbjct: 1587 SLLQPKEVLVFDFGS--EVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPG 1644
Query: 88 -------------------------GETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIK 122
ET +FK+ F DW + +S+ ++AQ K
Sbjct: 1645 ECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKN----PGELAQHK 1700
Query: 123 QIP------FDASKLHSSPQMAA-------------------QHNMVDDGSGKVEIWRVE 157
+ P +D +++ S PQ A + S V++W +
Sbjct: 1701 EDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHIL 1760
Query: 158 NNGRIQVDQNSYGEFYGGDCYIILYTY---------PRGQ-----------IIYTWQGAN 197
++ + S G+F+ GD Y++ + + +G+ + + WQG +
Sbjct: 1761 EFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRH 1820
Query: 198 ATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQ 257
+T E TSA +TV+LD G Q++V QGKEP L F+ ++ +G ++ +
Sbjct: 1821 STVSEKGTSALMTVELDEERG---AQVQVLQGKEPPCFLQCFQGG--MVVHSGRREEEEE 1875
Query: 258 APAPPTRLFQVRRNLASITRIVEVDVDANSLNS-NDVFVLKLPQNSGYIW---------- 306
RL+ VR + ++EV +SL S + VL + + Y+W
Sbjct: 1876 NVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTK 1935
Query: 307 -VGKGASQEEEKGAEYVASVLKCKTLRI---QEGEEPEEFWNSLG--GKKDYQTSPLLET 360
VG+ A+ + ++ A + + I EG EP FW++LG +K Y L +
Sbjct: 1936 EVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCM-LQDP 1994
Query: 361 QAEDHPPRLYGCSNKTGRF-------------VIEEIPGEFTQDDL---AEDDVMLLDAW 404
+ + PRL+ S+ +G F V+ +P F Q+DL + + L+D
Sbjct: 1995 GSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMP--FLQEDLYSAPQPALFLVDNH 2052
Query: 405 EQIFIWIG--KDANEV----------EKKESLKSAKMYLETDPSGRDKRTPI---VIIKQ 449
++++W G N++ ++K ++++ Y + G++ + P +I
Sbjct: 2053 HEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCK----GKNLKKPAPKSYLIHA 2108
Query: 450 GHEPPTFTGWFLGWD 464
G EP TFT F W+
Sbjct: 2109 GLEPLTFTNMFPSWE 2123
Score = 54.7 bits (130), Expect = 2e-07
Identities = 50/207 (24%), Positives = 92/207 (44%), Gaps = 36/207 (17%)
Query: 249 NGTSKKGGQAPAPPTRLF--QVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIW 306
N T + + P RL Q++ TR+VE A++LNS D F+L P + ++W
Sbjct: 1427 NLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPR--ASALNSGDCFLLLSP-HCCFLW 1483
Query: 307 VGKGASQEEEKGAEYVASVLK------CKTLRIQEGEE--------PEEFWNSLGGKKDY 352
VG+ A+ E+ A +A++++ C+ IQ EE ++FW LGG+ Y
Sbjct: 1484 VGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSY 1543
Query: 353 QTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDD-----------LAEDDVMLL 401
Q++ + LY + + + + DD L +V++
Sbjct: 1544 QSA------GDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVF 1597
Query: 402 DAWEQIFIWIGKDANEVEKKESLKSAK 428
D ++++W GK+ ++K + + AK
Sbjct: 1598 DFGSEVYVWHGKEVTLAQRKIAFQLAK 1624
>gi|150417971 supervillin isoform 1 [Homo sapiens]
Length = 1788
Score = 106 bits (265), Expect = 4e-23
Identities = 125/555 (22%), Positives = 229/555 (41%), Gaps = 136/555 (24%)
Query: 28 AMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEG 87
++L +E + D G+ +++VW GK+ +RK A + A+ +N I L G
Sbjct: 1161 SLLQPKEVLVFDFGS--EVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPG 1218
Query: 88 -------------------------GETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIK 122
ET +FK+ F DW + +S+ ++AQ K
Sbjct: 1219 ECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKN----PGELAQHK 1274
Query: 123 QIP------FDASKLHSSPQMAA-------------------QHNMVDDGSGKVEIWRVE 157
+ P +D +++ S PQ A + S V++W +
Sbjct: 1275 EDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHIL 1334
Query: 158 NNGRIQVDQNSYGEFYGGDCYIILYTY---------PRGQ-----------IIYTWQGAN 197
++ + S G+F+ GD Y++ + + +G+ + + WQG +
Sbjct: 1335 EFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRH 1394
Query: 198 ATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQ 257
+T E TSA +TV+LD G Q++V QGKEP L F+ ++ +G ++ +
Sbjct: 1395 STVSEKGTSALMTVELDEERG---AQVQVLQGKEPPCFLQCFQGG--MVVHSGRREEEEE 1449
Query: 258 APAPPTRLFQVRRNLASITRIVEVDVDANSLNS-NDVFVLKLPQNSGYIW---------- 306
RL+ VR + ++EV +SL S + VL + + Y+W
Sbjct: 1450 NVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTK 1509
Query: 307 -VGKGASQEEEKGAEYVASVLKCKTLRI---QEGEEPEEFWNSLG--GKKDYQTSPLLET 360
VG+ A+ + ++ A + + I EG EP FW++LG +K Y L +
Sbjct: 1510 EVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCM-LQDP 1568
Query: 361 QAEDHPPRLYGCSNKTGRF-------------VIEEIPGEFTQDDL---AEDDVMLLDAW 404
+ + PRL+ S+ +G F V+ +P F Q+DL + + L+D
Sbjct: 1569 GSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMP--FLQEDLYSAPQPALFLVDNH 1626
Query: 405 EQIFIWIG--KDANEV----------EKKESLKSAKMYLETDPSGRDKRTPI---VIIKQ 449
++++W G N++ ++K ++++ Y + G++ + P +I
Sbjct: 1627 HEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCK----GKNLKKPAPKSYLIHA 1682
Query: 450 GHEPPTFTGWFLGWD 464
G EP TFT F W+
Sbjct: 1683 GLEPLTFTNMFPSWE 1697
Score = 54.7 bits (130), Expect = 2e-07
Identities = 50/207 (24%), Positives = 92/207 (44%), Gaps = 36/207 (17%)
Query: 249 NGTSKKGGQAPAPPTRLF--QVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIW 306
N T + + P RL Q++ TR+VE A++LNS D F+L P + ++W
Sbjct: 1001 NLTEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPR--ASALNSGDCFLLLSP-HCCFLW 1057
Query: 307 VGKGASQEEEKGAEYVASVLK------CKTLRIQEGEE--------PEEFWNSLGGKKDY 352
VG+ A+ E+ A +A++++ C+ IQ EE ++FW LGG+ Y
Sbjct: 1058 VGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSY 1117
Query: 353 QTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDD-----------LAEDDVMLL 401
Q++ + LY + + + + DD L +V++
Sbjct: 1118 QSA------GDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVF 1171
Query: 402 DAWEQIFIWIGKDANEVEKKESLKSAK 428
D ++++W GK+ ++K + + AK
Sbjct: 1172 DFGSEVYVWHGKEVTLAQRKIAFQLAK 1198
>gi|41872646 cullin 7 [Homo sapiens]
Length = 1698
Score = 31.2 bits (69), Expect = 2.1
Identities = 26/83 (31%), Positives = 35/83 (42%), Gaps = 1/83 (1%)
Query: 259 PAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKG 318
P P RL Q S ++ ++ L D +LKL I VG GAS +E K
Sbjct: 1294 PCFPNRLPQQMLQSLSTSKELQRQFHVYQLQQLDQELLKLEDTEKKIQVGLGASGKEHK- 1352
Query: 319 AEYVASVLKCKTLRIQEGEEPEE 341
+E + + EGEE EE
Sbjct: 1353 SEKEEEAGAAAVVDVAEGEEEEE 1375
>gi|14589951 DNA directed RNA polymerase II polypeptide E [Homo
sapiens]
Length = 210
Score = 29.6 bits (65), Expect = 6.1
Identities = 15/48 (31%), Positives = 24/48 (50%)
Query: 56 PQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDK 103
P+E K +KT + + Q+M T+ ++ + G TP KQ D K
Sbjct: 77 PEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVDMAPK 124
>gi|4759344 centromere/kinetochore protein zw10 [Homo sapiens]
Length = 779
Score = 29.6 bits (65), Expect = 6.1
Identities = 9/43 (20%), Positives = 25/43 (58%)
Query: 402 DAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTPI 444
+ W+++ +W + + ES +++L T+ S ++++TP+
Sbjct: 179 EEWQKLIVWKFPPSKDTSSLESYLQTELHLYTEQSHKEEKTPM 221
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,441,351
Number of Sequences: 37866
Number of extensions: 825880
Number of successful extensions: 2026
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 1787
Number of HSP's gapped (non-prelim): 54
length of query: 468
length of database: 18,247,518
effective HSP length: 106
effective length of query: 362
effective length of database: 14,233,722
effective search space: 5152607364
effective search space used: 5152607364
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.