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Search of human proteins with 148727255
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148727255 microtubule associated serine/threonine kinase
family member 4 isoform a [Homo sapiens]
(2434 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148727255 microtubule associated serine/threonine kinase fami... 4903 0.0
gi|112363080 microtubule associated serine/threonine kinase 2 [H... 1678 0.0
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 1608 0.0
gi|150170729 microtubule associated serine/threonine kinase 3 [H... 1506 0.0
gi|4502023 AKT2 kinase [Homo sapiens] 232 3e-60
gi|62241015 AKT1 kinase [Homo sapiens] 228 7e-59
gi|62241013 AKT1 kinase [Homo sapiens] 228 7e-59
gi|62241011 AKT1 kinase [Homo sapiens] 228 7e-59
gi|24307971 serine/threonine kinase 38 like [Homo sapiens] 226 2e-58
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 226 2e-58
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 226 2e-58
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 226 3e-58
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 224 6e-58
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 223 1e-57
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 223 1e-57
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 223 2e-57
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 221 5e-57
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 219 2e-56
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 219 2e-56
gi|6005814 serine/threonine kinase 38 [Homo sapiens] 219 2e-56
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 219 2e-56
gi|5453976 protein kinase C, theta [Homo sapiens] 218 8e-56
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 217 1e-55
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 216 2e-55
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 216 2e-55
gi|4826948 protein kinase, X-linked [Homo sapiens] 216 2e-55
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 216 2e-55
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 216 3e-55
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 211 5e-54
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s... 211 5e-54
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 4903 bits (12718), Expect = 0.0
Identities = 2434/2434 (100%), Positives = 2434/2434 (100%)
Query: 1 MDESSILRRRGLQKELSLPRRGSLIDSQKWNCLVKRCRTSNRKSLIGNGQSPALPRPHSP 60
MDESSILRRRGLQKELSLPRRGSLIDSQKWNCLVKRCRTSNRKSLIGNGQSPALPRPHSP
Sbjct: 1 MDESSILRRRGLQKELSLPRRGSLIDSQKWNCLVKRCRTSNRKSLIGNGQSPALPRPHSP 60
Query: 61 LSAHAGNSPQDSPRNFSPSASAHFSFARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSS 120
LSAHAGNSPQDSPRNFSPSASAHFSFARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSS
Sbjct: 61 LSAHAGNSPQDSPRNFSPSASAHFSFARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSS 120
Query: 121 QEKLHQLPYQPTPDELHFLSKHFCTTESIATENRCRNTPMRPRSRSLSPGRSPACCDHEI 180
QEKLHQLPYQPTPDELHFLSKHFCTTESIATENRCRNTPMRPRSRSLSPGRSPACCDHEI
Sbjct: 121 QEKLHQLPYQPTPDELHFLSKHFCTTESIATENRCRNTPMRPRSRSLSPGRSPACCDHEI 180
Query: 181 IMMNHVYKERFPKATAQMEERLKEIITSYSPDNVLPLADGVLSFTHHQIIELARDCLDKS 240
IMMNHVYKERFPKATAQMEERLKEIITSYSPDNVLPLADGVLSFTHHQIIELARDCLDKS
Sbjct: 181 IMMNHVYKERFPKATAQMEERLKEIITSYSPDNVLPLADGVLSFTHHQIIELARDCLDKS 240
Query: 241 HQGLITSRYFLELQHKLDKLLQEAHDRSESGELAFIKQLVRKILIVIARPARLLECLEFD 300
HQGLITSRYFLELQHKLDKLLQEAHDRSESGELAFIKQLVRKILIVIARPARLLECLEFD
Sbjct: 241 HQGLITSRYFLELQHKLDKLLQEAHDRSESGELAFIKQLVRKILIVIARPARLLECLEFD 300
Query: 301 PEEFYYLLEAAEGHAKEGQGIKTDIPRYIISQLGLNKDPLEEMAHLGNYDSGTAETPETD 360
PEEFYYLLEAAEGHAKEGQGIKTDIPRYIISQLGLNKDPLEEMAHLGNYDSGTAETPETD
Sbjct: 301 PEEFYYLLEAAEGHAKEGQGIKTDIPRYIISQLGLNKDPLEEMAHLGNYDSGTAETPETD 360
Query: 361 ESVSSSNASLKLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILR 420
ESVSSSNASLKLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILR
Sbjct: 361 ESVSSSNASLKLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILR 420
Query: 421 NQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDM 480
NQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDM
Sbjct: 421 NQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDM 480
Query: 481 ARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEG 540
ARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEG
Sbjct: 481 ARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEG 540
Query: 541 HIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPE 600
HIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPE
Sbjct: 541 HIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPE 600
Query: 601 ELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWN 660
ELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWN
Sbjct: 601 ELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWN 660
Query: 661 SLLRQKAEFIPQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQFSSCSHRFS 720
SLLRQKAEFIPQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQFSSCSHRFS
Sbjct: 661 SLLRQKAEFIPQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQFSSCSHRFS 720
Query: 721 KVFSSIDRITQNSAEEKEDSVDKTKSTTLPSTETLSWSSEYSEMQQLSTSNSSDTESNRH 780
KVFSSIDRITQNSAEEKEDSVDKTKSTTLPSTETLSWSSEYSEMQQLSTSNSSDTESNRH
Sbjct: 721 KVFSSIDRITQNSAEEKEDSVDKTKSTTLPSTETLSWSSEYSEMQQLSTSNSSDTESNRH 780
Query: 781 KLSSGLLPKLAISTEGEQDEAASCPGDPHEEPGKPALPPEECAQEEPEVTTPASTISSST 840
KLSSGLLPKLAISTEGEQDEAASCPGDPHEEPGKPALPPEECAQEEPEVTTPASTISSST
Sbjct: 781 KLSSGLLPKLAISTEGEQDEAASCPGDPHEEPGKPALPPEECAQEEPEVTTPASTISSST 840
Query: 841 LSVGSFSEHLDQINGRSECVDSTDNSSKPSSEPASHMARQRLESTEKKKISGKVTKSLSA 900
LSVGSFSEHLDQINGRSECVDSTDNSSKPSSEPASHMARQRLESTEKKKISGKVTKSLSA
Sbjct: 841 LSVGSFSEHLDQINGRSECVDSTDNSSKPSSEPASHMARQRLESTEKKKISGKVTKSLSA 900
Query: 901 SALSLMIPGDMFAVSPLGSPMSPHSLSSDPSSSRDSSPSRDSSAASASPHQPIVIHSSGK 960
SALSLMIPGDMFAVSPLGSPMSPHSLSSDPSSSRDSSPSRDSSAASASPHQPIVIHSSGK
Sbjct: 901 SALSLMIPGDMFAVSPLGSPMSPHSLSSDPSSSRDSSPSRDSSAASASPHQPIVIHSSGK 960
Query: 961 NYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQAGLKAGDLITHINGEPVHGLVHTE 1020
NYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQAGLKAGDLITHINGEPVHGLVHTE
Sbjct: 961 NYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQAGLKAGDLITHINGEPVHGLVHTE 1020
Query: 1021 VIELLLKSGNKVSITTTPFENTSIKTGPARRNSYKSRMVRRSKKSKKKESLERRRSLFKK 1080
VIELLLKSGNKVSITTTPFENTSIKTGPARRNSYKSRMVRRSKKSKKKESLERRRSLFKK
Sbjct: 1021 VIELLLKSGNKVSITTTPFENTSIKTGPARRNSYKSRMVRRSKKSKKKESLERRRSLFKK 1080
Query: 1081 LAKQPSPLLHTSRSFSCLNRSLSSGESLPGSPTHSLSPRSPTPSYRSTPDFPSGTNSSQS 1140
LAKQPSPLLHTSRSFSCLNRSLSSGESLPGSPTHSLSPRSPTPSYRSTPDFPSGTNSSQS
Sbjct: 1081 LAKQPSPLLHTSRSFSCLNRSLSSGESLPGSPTHSLSPRSPTPSYRSTPDFPSGTNSSQS 1140
Query: 1141 SSPSSSAPNSPAGSGHIRPSTLHGLAPKLGGQRYRSGRRKSAGNIPLSPLARTPSPTPQP 1200
SSPSSSAPNSPAGSGHIRPSTLHGLAPKLGGQRYRSGRRKSAGNIPLSPLARTPSPTPQP
Sbjct: 1141 SSPSSSAPNSPAGSGHIRPSTLHGLAPKLGGQRYRSGRRKSAGNIPLSPLARTPSPTPQP 1200
Query: 1201 TSPQRSPSPLLGHSLGNSKIAQAFPSKMHSPPTIVRHIVRPKSAEPPRSPLLKRVQSEEK 1260
TSPQRSPSPLLGHSLGNSKIAQAFPSKMHSPPTIVRHIVRPKSAEPPRSPLLKRVQSEEK
Sbjct: 1201 TSPQRSPSPLLGHSLGNSKIAQAFPSKMHSPPTIVRHIVRPKSAEPPRSPLLKRVQSEEK 1260
Query: 1261 LSPSYGSDKKHLCSRKHSLEVTQEEVQREQSQREAPLQSLDENVCDVPPLSRARPVEQGC 1320
LSPSYGSDKKHLCSRKHSLEVTQEEVQREQSQREAPLQSLDENVCDVPPLSRARPVEQGC
Sbjct: 1261 LSPSYGSDKKHLCSRKHSLEVTQEEVQREQSQREAPLQSLDENVCDVPPLSRARPVEQGC 1320
Query: 1321 LKRPVSRKVGRQESVDDLDRDKLKAKVVVKKADGFPEKQESHQKSHGPGSDLENFALFKL 1380
LKRPVSRKVGRQESVDDLDRDKLKAKVVVKKADGFPEKQESHQKSHGPGSDLENFALFKL
Sbjct: 1321 LKRPVSRKVGRQESVDDLDRDKLKAKVVVKKADGFPEKQESHQKSHGPGSDLENFALFKL 1380
Query: 1381 EEREKKVYPKAVERSSTFENKASMQEAPPLGSLLKDALHKQASVRASEGAMSDGRVPAEH 1440
EEREKKVYPKAVERSSTFENKASMQEAPPLGSLLKDALHKQASVRASEGAMSDGRVPAEH
Sbjct: 1381 EEREKKVYPKAVERSSTFENKASMQEAPPLGSLLKDALHKQASVRASEGAMSDGRVPAEH 1440
Query: 1441 RQGGGDFRRAPAPGTLQDGLCHSLDRGISGKGEGTEKSSQAKELLRCEKLDSKLANIDYL 1500
RQGGGDFRRAPAPGTLQDGLCHSLDRGISGKGEGTEKSSQAKELLRCEKLDSKLANIDYL
Sbjct: 1441 RQGGGDFRRAPAPGTLQDGLCHSLDRGISGKGEGTEKSSQAKELLRCEKLDSKLANIDYL 1500
Query: 1501 RKKMSLEDKEDNLCPVLKPKMTAGSHECLPGNPVRPTGGQQEPPPASESRAFVSSTHAAQ 1560
RKKMSLEDKEDNLCPVLKPKMTAGSHECLPGNPVRPTGGQQEPPPASESRAFVSSTHAAQ
Sbjct: 1501 RKKMSLEDKEDNLCPVLKPKMTAGSHECLPGNPVRPTGGQQEPPPASESRAFVSSTHAAQ 1560
Query: 1561 MSAVSFVPLKALTGRVDSGTEKPGLVAPESPVRKSPSEYKLEGRSVSCLKPIEGTLDIAL 1620
MSAVSFVPLKALTGRVDSGTEKPGLVAPESPVRKSPSEYKLEGRSVSCLKPIEGTLDIAL
Sbjct: 1561 MSAVSFVPLKALTGRVDSGTEKPGLVAPESPVRKSPSEYKLEGRSVSCLKPIEGTLDIAL 1620
Query: 1621 LSGPQASKTELPSPESAQSPSPSGDVRASVPPVLPSSSGKKNDTTSARELSPSSLKMNKS 1680
LSGPQASKTELPSPESAQSPSPSGDVRASVPPVLPSSSGKKNDTTSARELSPSSLKMNKS
Sbjct: 1621 LSGPQASKTELPSPESAQSPSPSGDVRASVPPVLPSSSGKKNDTTSARELSPSSLKMNKS 1680
Query: 1681 YLLEPWFLPPSRGLQNSPAVSLPDPEFKRDRKGPHPTARSPGTVMESNPQQREGSSPKHQ 1740
YLLEPWFLPPSRGLQNSPAVSLPDPEFKRDRKGPHPTARSPGTVMESNPQQREGSSPKHQ
Sbjct: 1681 YLLEPWFLPPSRGLQNSPAVSLPDPEFKRDRKGPHPTARSPGTVMESNPQQREGSSPKHQ 1740
Query: 1741 DHTTDPKLLTCLGQNLHSPDLARPRCPLPPEASPSREKPGLRESSERGPPTARSERSAAR 1800
DHTTDPKLLTCLGQNLHSPDLARPRCPLPPEASPSREKPGLRESSERGPPTARSERSAAR
Sbjct: 1741 DHTTDPKLLTCLGQNLHSPDLARPRCPLPPEASPSREKPGLRESSERGPPTARSERSAAR 1800
Query: 1801 ADTCREPSMELCFPETAKTSDNSKNLLSVGRTHPDFYTQTQAMEKAWAPGGKTNHKDGPG 1860
ADTCREPSMELCFPETAKTSDNSKNLLSVGRTHPDFYTQTQAMEKAWAPGGKTNHKDGPG
Sbjct: 1801 ADTCREPSMELCFPETAKTSDNSKNLLSVGRTHPDFYTQTQAMEKAWAPGGKTNHKDGPG 1860
Query: 1861 EARPPPRDNSSLHSAGIPCEKELGKVRRGVEPKPEALLARRSLQPPGIESEKSEKLSSFP 1920
EARPPPRDNSSLHSAGIPCEKELGKVRRGVEPKPEALLARRSLQPPGIESEKSEKLSSFP
Sbjct: 1861 EARPPPRDNSSLHSAGIPCEKELGKVRRGVEPKPEALLARRSLQPPGIESEKSEKLSSFP 1920
Query: 1921 SLQKDGAKEPERKEQPLQRHPSSIPPPPLTAKDLSSPAARQHCSSPSHASGREPGAKPST 1980
SLQKDGAKEPERKEQPLQRHPSSIPPPPLTAKDLSSPAARQHCSSPSHASGREPGAKPST
Sbjct: 1921 SLQKDGAKEPERKEQPLQRHPSSIPPPPLTAKDLSSPAARQHCSSPSHASGREPGAKPST 1980
Query: 1981 AEPSSSPQDPPKPVAAHSESSSHKPRPGPDPGPPKTKHPDRSLSSQKPSVGATKGKEPAT 2040
AEPSSSPQDPPKPVAAHSESSSHKPRPGPDPGPPKTKHPDRSLSSQKPSVGATKGKEPAT
Sbjct: 1981 AEPSSSPQDPPKPVAAHSESSSHKPRPGPDPGPPKTKHPDRSLSSQKPSVGATKGKEPAT 2040
Query: 2041 QSLGGSSREGKGHSKSGPDVFPATPGSQNKASDGIGQGEGGPSVPLHTDRAPLDAKPQPT 2100
QSLGGSSREGKGHSKSGPDVFPATPGSQNKASDGIGQGEGGPSVPLHTDRAPLDAKPQPT
Sbjct: 2041 QSLGGSSREGKGHSKSGPDVFPATPGSQNKASDGIGQGEGGPSVPLHTDRAPLDAKPQPT 2100
Query: 2101 SGGRPLEVLEKPVHLPRPGHPGPSEPADQKLSAVGEKQTLSPKHPKPSTVKDCPTLCKQT 2160
SGGRPLEVLEKPVHLPRPGHPGPSEPADQKLSAVGEKQTLSPKHPKPSTVKDCPTLCKQT
Sbjct: 2101 SGGRPLEVLEKPVHLPRPGHPGPSEPADQKLSAVGEKQTLSPKHPKPSTVKDCPTLCKQT 2160
Query: 2161 DNRQTDKSPSQPAANTDRRAEGKKCTEALYAPAEGDKLEAGLSFVHSENRLKGAERPAAG 2220
DNRQTDKSPSQPAANTDRRAEGKKCTEALYAPAEGDKLEAGLSFVHSENRLKGAERPAAG
Sbjct: 2161 DNRQTDKSPSQPAANTDRRAEGKKCTEALYAPAEGDKLEAGLSFVHSENRLKGAERPAAG 2220
Query: 2221 VGKGFPEARGKGPGPQKPPTEADKPNGMKRSPSATGQSSFRSTALPEKSLSCSSSFPETR 2280
VGKGFPEARGKGPGPQKPPTEADKPNGMKRSPSATGQSSFRSTALPEKSLSCSSSFPETR
Sbjct: 2221 VGKGFPEARGKGPGPQKPPTEADKPNGMKRSPSATGQSSFRSTALPEKSLSCSSSFPETR 2280
Query: 2281 AGVREASAASSDTSSAKAAGGMLELPAPSNRDHRKAQPAGEGRTHMTKSDSLPSFRVSTL 2340
AGVREASAASSDTSSAKAAGGMLELPAPSNRDHRKAQPAGEGRTHMTKSDSLPSFRVSTL
Sbjct: 2281 AGVREASAASSDTSSAKAAGGMLELPAPSNRDHRKAQPAGEGRTHMTKSDSLPSFRVSTL 2340
Query: 2341 PLESHHPDPNTMGGASHRDRALSVTATVGETKGKDPAPAQPPPARKQNVGRDVTKPSPAP 2400
PLESHHPDPNTMGGASHRDRALSVTATVGETKGKDPAPAQPPPARKQNVGRDVTKPSPAP
Sbjct: 2341 PLESHHPDPNTMGGASHRDRALSVTATVGETKGKDPAPAQPPPARKQNVGRDVTKPSPAP 2400
Query: 2401 NTDRPISLSNEKDFVVRQRRGKESLRSSPHKKAL 2434
NTDRPISLSNEKDFVVRQRRGKESLRSSPHKKAL
Sbjct: 2401 NTDRPISLSNEKDFVVRQRRGKESLRSSPHKKAL 2434
>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
sapiens]
Length = 1798
Score = 1678 bits (4345), Expect = 0.0
Identities = 926/1454 (63%), Positives = 1073/1454 (73%), Gaps = 100/1454 (6%)
Query: 14 KELSLPRRGSLIDSQKWNCLVKRCRTSNRKSLI-GNGQSPALPRPHSPLSAHAGNSPQDS 72
KELSLPRRGS CRTSNRKSLI + SP LPRPHSPL H GNSP DS
Sbjct: 157 KELSLPRRGSF------------CRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDS 204
Query: 73 PRNFSPSASAHFSF--ARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPYQ 130
PRNFSP+A AHFSF ARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLP+Q
Sbjct: 205 PRNFSPNAPAHFSFVPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQ 264
Query: 131 PTPDELHFLSKHFCTTESIATENRCRNTPMRPRSRSLSPGRSPACCDHEIIMMNHVYKER 190
PT DELHFL+KHF +TES+ E ++ MRPRSRSLSPGRSP D EIIMMNHVYKER
Sbjct: 265 PTADELHFLTKHF-STESVPDEEGRQSPAMRPRSRSLSPGRSPVSFDSEIIMMNHVYKER 323
Query: 191 FPKATAQMEERLKEIITSYSPDNVLPLADGVLSFTHHQIIELARDCLDKSHQGLITSRYF 250
FPKATAQMEERL E I+S +PD+VLPLADG LSF HHQ+IE+ARDCLDKS GLITS+YF
Sbjct: 324 FPKATAQMEERLAEFISSNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLITSQYF 383
Query: 251 LELQHKLDKLLQEAHDRSESGELAFIKQLVRKILIVIARPARLLECLEFDPEEFYYLLEA 310
ELQ L+KLLQ+AH+RSES E+AF+ QLV+K++I+IARPARLLECLEFDPEEFY+LLEA
Sbjct: 384 YELQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEA 443
Query: 311 AEGHAKEGQGIKTDIPRYIISQLGLNKDPLEEMAHLGNYDSGTAETPETDESVSSSNASL 370
AEGHAKEGQGIK DIPRYI+SQLGL +DPLEEMA L + DS +TPETD+S+ ASL
Sbjct: 444 AEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSCDS--PDTPETDDSIEGHGASL 501
Query: 371 KLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVER 430
++ P E DFETIKLISNGAYGAV+ VRHK +RQRFAMKKINKQNLILRNQIQQAFVER
Sbjct: 502 PSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVER 561
Query: 431 DILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVL 490
DILTFAENPFVVSM+CSF+T+RHLCMVMEYVEGGDCATL+KN+G LPVDM R+YFAETVL
Sbjct: 562 DILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVL 621
Query: 491 ALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFL 550
ALEYLHNYGIVHRDLKPDNLL+TSMGHIKLTDFGLSK+GLMS+TTNLYEGHIEKDAREFL
Sbjct: 622 ALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFL 681
Query: 551 DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDE 610
DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDE
Sbjct: 682 DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDE 741
Query: 611 INWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQKAEFI 670
I WPE DEA PPDAQDL + LL QNPLERLGTG AYEVKQH FF LDW LLRQKAEFI
Sbjct: 742 IVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFI 801
Query: 671 PQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQFSSCSHRFSKVFSSIDRIT 730
PQLESEDDTSYFDTRSE+YHHM++E+E++ + ED +EIRQFSSCS RF+KV+SS++R++
Sbjct: 802 PQLESEDDTSYFDTRSERYHHMDSEDEEEVS-EDGCLEIRQFSSCSPRFNKVYSSMERLS 860
Query: 731 ------------QNSAEEKEDSVD-------KTKSTTLPSTETLSWSSEYSEMQQLSTSN 771
++ +EEKED D + +S + S E L ++LS S
Sbjct: 861 LLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGSPEIL--------RKRLSVSE 912
Query: 772 SSDTESNR------HKLSSGLL--------PKLAISTEGEQDEAASCPGDPHEEPGKPAL 817
SS TES+ + SGLL P+ A ST Q + P G
Sbjct: 913 SSHTESDSSPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWVLTPPSGEGVSGP 972
Query: 818 PPEECAQEEPEVTTPASTISSSTLSVGSFSEHLDQINGRSECVDSTDNSSKPSSEPASHM 877
E ++ P++ A SS S + GR + ++K S+ A
Sbjct: 973 VTEHSGEQRPKLDEEAVGRSSG-------SSPAMETRGRGTSQLAEGATAKAISDLAVRR 1025
Query: 878 ARQRL---ESTEKK--KISGKVTKSLSASALSLMIPGDMFAVSPLGSPMSPHSLSSDPSS 932
AR RL +STEK+ + KV KS SA+ALSL+IP + SPL SPMSPHS SS+P S
Sbjct: 1026 ARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNP-S 1084
Query: 933 SRDSSPSRDSSAASASPHQPIVIHSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGS 992
SRDSSPSRD A S PI+IH +GK YGFT+RAIRVY+GDSD+YTVHH+VW+VE+G
Sbjct: 1085 SRDSSPSRDFLPALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGG 1144
Query: 993 PACQAGLKAGDLITHINGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTSIKTGPARRN 1052
PA +AGL+ GDLITH+NGEPVHGLVHTEV+EL+LKSGNKV+I+TTP ENTSIK GPAR+
Sbjct: 1145 PASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPARKG 1204
Query: 1053 SYKSRMVRRSKKSKKKESLE--RRRSLFKKLAKQPSPLLHTSRSFSCLNRSLSSGESLPG 1110
SYK++M RRSK+S+ K+ E +R SLF+K+ KQ S LLHTSRS S LNRSLSSGES PG
Sbjct: 1205 SYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQAS-LLHTSRSLSSLNRSLSSGESGPG 1263
Query: 1111 SPT--HSLSPRSPTPSYRSTPD--FPSGTNSSQSSSPSSSAPNSPAGSGHIRPSTLHGLA 1166
SPT HSLSPRSPT YR TPD G NSSQSSSPSSS P+SPAGSGH RPS+LHGLA
Sbjct: 1264 SPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLA 1323
Query: 1167 PKLGGQRYRSGRRKSAGNIPLSPLARTPSPTPQPTSPQRSPSPLLGHSLGNSKIAQAFPS 1226
PKL Q YRS RRKSAG+IPLSPLA TPSP P SPQRSPSPL GH +AQAFP+
Sbjct: 1324 PKLQRQ-YRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGH------VAQAFPT 1376
Query: 1227 KMHSPPTIVRHIVRPKSAEPPRSPLLKRVQSEEKLSPSY-GSDKKHLCSRKHSLEVTQEE 1285
K+H P + R + RPKSAEPPRSPLLKRVQS EKL+ + S+KK SRKHSL++ E
Sbjct: 1377 KLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSE 1436
Query: 1286 VQREQSQRE-APLQSLDENVCDVPPLSRARPVEQGCLKRPVSRKVGRQESVDDLDRDKLK 1344
+++E RE +PL+ + V A P +G L+ SR +G R+ L+
Sbjct: 1437 LKKELPPREVSPLEVVGAR--SVLSGKGALP-GKGVLQPAPSRALGTLRQDRAERRESLQ 1493
Query: 1345 AKVVVKKADGF-PEKQESHQKSHGPGSDLENFALFKLEEREKKVYPKAVERS---STFEN 1400
+ +++ D + +E + S G + +L E + V PK S F +
Sbjct: 1494 KQEAIREVDSSEDDTEEGPENSQG----AQELSLAPHPEVSQSVAPKGAGESGEEDPFPS 1549
Query: 1401 KASMQEAPPLGSLL 1414
+ P + SLL
Sbjct: 1550 RDPRSLGPMVPSLL 1563
Score = 36.2 bits (82), Expect = 0.40
Identities = 118/504 (23%), Positives = 172/504 (34%), Gaps = 71/504 (14%)
Query: 1662 NDTTSARELSPSSLKMNKSYLLEPWFLPPSRGLQNSP-AVSLPDPEFKRDRKGPHPTARS 1720
N + S+ E P S S+ L P P++G + +P AV + S
Sbjct: 1252 NRSLSSGESGPGS--PTHSHSLSP--RSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSS 1307
Query: 1721 PGTVMESNPQQREGSSPKHQDHTTDPKLLTCLGQNLHSPDLARPRCPLPPEASPSREKPG 1780
P + P G +PK Q P+ + G SP LA P PP ASP R
Sbjct: 1308 PAGSGHTRPSSLHGLAPKLQRQYRSPRRKSA-GSIPLSP-LAHTPSPPPPTASPQRSPSP 1365
Query: 1781 LRESSERGPPTARSERSAARADTCREPSMELCFPETAKTSDNSKNLLSVGRTHPDFYTQT 1840
L + PT R S E K +++ L +
Sbjct: 1366 LSGHVAQAFPTKLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAA----------L 1415
Query: 1841 QAMEKAWAPGGKTNHKDGPGEARP--PPRDNSSLHSAG---IPCEKELGKVRRGVEPKPE 1895
A EK A K + E + PPR+ S L G + K + ++P P
Sbjct: 1416 AASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPS 1475
Query: 1896 ALLA--RRSLQPPGIESEKSEKLSSFPSLQKDGAKEPER----KEQPLQRHP---SSIPP 1946
L R+ +K E + S + D + PE +E L HP S+ P
Sbjct: 1476 RALGTLRQDRAERRESLQKQEAIREVDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAP 1535
Query: 1947 PPLTAKDLSSPAARQHCSS-----PSHASGREPGAKPSTAEPSSSPQ---DPPKPVAAHS 1998
P + S PS +G G P E S P P+ + +
Sbjct: 1536 KGAGESGEEDPFPSRDPRSLGPMVPSLLTGITLG--PPRMESPSGPHRRLGSPQAIEEAA 1593
Query: 1999 ESSSHKPRPG----PDPGPP----KTKH-PDRSLSSQKPSVGATKGKEPATQSLGGSSRE 2049
SSS P G DP PP K +H ++L++ PS T G P + SS
Sbjct: 1594 SSSSAGPNLGQSGATDPIPPEGCWKAQHLHTQALTALSPS---TSGLTPTSSCSPPSSTS 1650
Query: 2050 GKGHSKS------GPDVFPATPGSQNKASDGIGQGEGGPSVPLHTDRAPLDAKPQPTSGG 2103
GK S GPD A+P + + G+ + + T P + P+
Sbjct: 1651 GKLSMWSWKSLIEGPD--RASPSRKATMAGGLANLQ---DLENTTPAQPKNLSPRE---- 1701
Query: 2104 RPLEVLEKPVHLPRPGHPGPSEPA 2127
+ +P PR HP +P+
Sbjct: 1702 ---QGKTQPPSAPRLAHPSYEDPS 1722
>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
sapiens]
Length = 1570
Score = 1608 bits (4163), Expect = 0.0
Identities = 876/1353 (64%), Positives = 1013/1353 (74%), Gaps = 78/1353 (5%)
Query: 35 KRCRTSNRKSLIGNGQSPALPRPHSPLSAHAGNSPQDSPRNFSPSASAHFSFA--RRTDG 92
K CRTSNRKSLI SP LPRPHSPL H G+SP DSPRNFSP+ AHFSFA RR DG
Sbjct: 27 KSCRTSNRKSLILTSTSPTLPRPHSPLPGHLGSSPLDSPRNFSPNTPAHFSFASSRRADG 86
Query: 93 RRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPYQPTPDELHFLSKHFCTTESIATE 152
RRWSLASLPSSGYGTNTPSSTVSSSCSSQE+LHQLPYQPT DELHFLSKHF +TESI E
Sbjct: 87 RRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQLPYQPTVDELHFLSKHFGSTESITDE 146
Query: 153 NRCRNTP-MRPRSRSLSPGRSPACCDHEIIMMNHVYKERFPKATAQMEERLKEIITSYSP 211
+ R +P +RPRSRSLSPGRSP+ D+EI+MMNHVYKERFPKATAQMEE+L++ +Y P
Sbjct: 147 DGGRRSPAVRPRSRSLSPGRSPSSYDNEIVMMNHVYKERFPKATAQMEEKLRDFTRAYEP 206
Query: 212 DNVLPLADGVLSFTHHQIIELARDCLDKSHQGLITSRYFLELQHKLDKLLQEAHDRSESG 271
D+VLPLADGVLSF HHQIIELARDCL KS GLIT+ YF ELQ L+KLLQ+A++RSES
Sbjct: 207 DSVLPLADGVLSFIHHQIIELARDCLTKSRDGLITTVYFYELQENLEKLLQDAYERSESL 266
Query: 272 ELAFIKQLVRKILIVIARPARLLECLEFDPEEFYYLLEAAEGHAKEGQGIKTDIPRYIIS 331
E+AF+ QLV+K+LI+I+RPARLLECLEF+PEEFY+LLEAAEGHAKEG +KTDIPRYII
Sbjct: 267 EVAFVTQLVKKLLIIISRPARLLECLEFNPEEFYHLLEAAEGHAKEGHLVKTDIPRYIIR 326
Query: 332 QLGLNKDPLEEMAHLGNYDSGTAETPETDESVSSSNASLKLRRKPRESDFETIKLISNGA 391
QLGL +DP ++ HL DSG + TPE D+ S S K ++ P E+DF+TIKLISNGA
Sbjct: 327 QLGLTRDPFPDVVHLEEQDSGGSNTPEQDDL--SEGRSSKAKKPPGENDFDTIKLISNGA 384
Query: 392 YGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETR 451
YGAVY VRH+++RQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVV M+CSFETR
Sbjct: 385 YGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETR 444
Query: 452 RHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLL 511
RHLCMVMEYVEGGDCATL+KN+G LPV+MARMYFAETVLALEYLHNYGIVHRDLKPDNLL
Sbjct: 445 RHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLL 504
Query: 512 VTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGY 571
+TSMGHIKLTDFGLSK+GLMS+TTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGY
Sbjct: 505 ITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGY 564
Query: 572 GKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLL 631
GKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISD+I WPE DEA P +AQ LI+ L
Sbjct: 565 GKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSL 624
Query: 632 LRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQKAEFIPQLESEDDTSYFDTRSEKYHH 691
L+ NPL RLG GGA+EVKQH FFR LDW LLRQKAEFIP LESEDDTSYFDTRS++YHH
Sbjct: 625 LQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFIPHLESEDDTSYFDTRSDRYHH 684
Query: 692 METEEEDDTNDEDFNVEIRQFSSCSHRFSKVFSSIDRITQN---------SAEEKEDSVD 742
+ + +EDDT +E+ VEIRQFSSCS RFSKV+SS+++++Q+ + ++E S
Sbjct: 685 VNSYDEDDTTEEE-PVEIRQFSSCSPRFSKVYSSMEQLSQHEPKTPVAAAGSSKREPSTK 743
Query: 743 KTKSTTLPSTETL--------SWSSEYSEMQQLSTSNSSDTESN-------RHKLSSGLL 787
+ E L +W E+++ S S +S E R + S+ L
Sbjct: 744 GPEEKVAGKREGLGGLTLREKTWRGGSPEIKRFSASEASFLEGEASPPLGARRRFSALLE 803
Query: 788 PKLAISTEGEQDEA-ASCPGDPHEEP--GKPALPPEECAQEEPEVTTPASTISSSTLSVG 844
P + + ++DEA P P +P A P+E Q E T S G
Sbjct: 804 PSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAPKEETQGE------------GTSSAG 851
Query: 845 SFSEHLDQINGRSECVDSTD-NSSKPSS------EPASHMARQRLESTEKK--KISGKVT 895
SE D+ C S D ++S P + A H + EK+ + GKV
Sbjct: 852 D-SEATDRPRPGDLCPPSKDGDASGPRATNDLVLRRARHQQMSGDVAVEKRPSRTGGKVI 910
Query: 896 KSLSASALSLMIPG-DMFAVSPLGSPMSPHSLSSDPSSSRDSSPSRDSSAASASPHQPIV 954
KS SA+ALS+MIP D SPL SPMSP SLSS+P SSRDSSPSRD S A + PI
Sbjct: 911 KSASATALSVMIPAVDPHGSSPLASPMSPRSLSSNP-SSRDSSPSRDYSPAVSGLRSPIT 969
Query: 955 IHSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQAGLKAGDLITHINGEPVH 1014
I SGK YGFT+RAIRVY+GD+D+Y+VHHIVW+VEEG PA +AGL AGDLITH+NGEPVH
Sbjct: 970 IQRSGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPAQEAGLCAGDLITHVNGEPVH 1029
Query: 1015 GLVHTEVIELLLKSGNKVSITTTPFENTSIKTGPARRNSYKSRMVRRSKKSKKKESLE-- 1072
G+VH EV+EL+LKSGNKV++TTTPFENTSI+ GPARR+SYK++M RR+K+ KE E
Sbjct: 1030 GMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSYKAKMARRNKRPSAKEGQESK 1089
Query: 1073 RRRSLFKKLAKQPSPLLHTSRSFSCLNRSLSSGESLPGSPTHSLSPRSPTPSYRSTPDFP 1132
+R SLF+K+ KQ S LLHTSRS S LNRSLSS +SLPGSPTH L RSPT SYRSTPD
Sbjct: 1090 KRSSLFRKITKQ-SNLLHTSRSLSSLNRSLSSSDSLPGSPTHGLPARSPTHSYRSTPDSA 1148
Query: 1133 SGTNSSQSSSPSSSAPNSPAGSG--HIRPSTLHGLAPKLGGQRYRSGRRKSAGNIPLSPL 1190
SSQSSSP+SS PNSPA S HIRPSTLHGL+PKL Q YRS R KSAGNIPLSPL
Sbjct: 1149 YLGASSQSSSPASSTPNSPASSASHHIRPSTLHGLSPKLHRQ-YRSARCKSAGNIPLSPL 1207
Query: 1191 ARTPSPTPQPTSPQRSPSPLLGHSLGNSKIAQAFPSKMHSPPTIVRHIVRPKSAEPPRSP 1250
A TPSPT Q SP PL GH++G+S Q+FP+K+HS P +VR RPKSAEPPRSP
Sbjct: 1208 AHTPSPT------QASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVR--PRPKSAEPPRSP 1259
Query: 1251 LLKRVQSEEKLSPSYGSDKKHLCSRKHSLEVTQEEVQREQSQREAPLQSLDENVCDVPPL 1310
LLKRVQS EKL S +DKK RKHSLEV + R+ E L SL E+ + PP+
Sbjct: 1260 LLKRVQSAEKLGASLSADKKG-ALRKHSLEVGHPDF-RKDFHGELALHSLAESDGETPPV 1317
Query: 1311 SRARPVEQGCLKRPVSRKVGRQESVDDLDRDKL 1343
G ++ R++GRQES L D L
Sbjct: 1318 EGL-----GAPRQVAVRRLGRQESPLSLGADPL 1345
Score = 47.8 bits (112), Expect = 1e-04
Identities = 107/473 (22%), Positives = 169/473 (35%), Gaps = 65/473 (13%)
Query: 1708 KRDRKGPHPTARSPGTVMESNPQQREGSSPKHQDHTTDPKLLTCLGQNLHSPDLARPRCP 1767
K R+ P+A+ + + R+ + + HT+ + L+ L ++L S D + P P
Sbjct: 1072 KMARRNKRPSAKEGQESKKRSSLFRKITKQSNLLHTS--RSLSSLNRSLSSSD-SLPGSP 1128
Query: 1768 LP--PEASPSREKPGLRESSERGPPTARSERSAARADTCREPSMELCFPETAKTSDNSKN 1825
P SP+ +S+ G A S+ S+ + T P+ +A
Sbjct: 1129 THGLPARSPTHSYRSTPDSAYLG---ASSQSSSPASSTPNSPA------SSASHHIRPST 1179
Query: 1826 LLSVGRTHPDFYTQTQAMEKAWAPGGKTNHKDGPGEARPPPRDNSSLHSAGIPCE--KEL 1883
L + Y + P H P +A PPP ++ S+ +L
Sbjct: 1180 LHGLSPKLHRQYRSARCKSAGNIPLSPLAHTPSPTQASPPPLPGHTVGSSHTTQSFPAKL 1239
Query: 1884 GKVRRGVEPKPEALLARRSLQPPGIESEKSEKLSSFPSLQKDGAKEPERKEQPLQRHPSS 1943
V P+P +S +PP +S L S +K GA K+ L++H
Sbjct: 1240 HSSPPVVRPRP------KSAEPP-----RSPLLKRVQSAEKLGASLSADKKGALRKHSLE 1288
Query: 1944 IPPPP-------------LTAKDLSSPAARQHCSSPSHASGREPGAKPSTAEPSSSPQDP 1990
+ P L D +P + +P + R G + S P S DP
Sbjct: 1289 VGHPDFRKDFHGELALHSLAESDGETPPV-EGLGAPRQVAVRRLGRQES---PLSLGADP 1344
Query: 1991 PKPVAAHSESSSHKPRPGPDPG----PPKTKHPD-RSLSSQKPSVGATKGKEPATQSLGG 2045
P A S K + P PP+ P R+L VG T+ + T+
Sbjct: 1345 LLPEGASRPPVSSKEKESPGGAEACTPPRATTPGGRTLERD---VGCTRHQSVQTE---- 1397
Query: 2046 SSREGKGHSKSGPDVFPATPGSQNKASDGIGQGEGG-PSVPLHTDRAPLDAK---PQPTS 2101
+G G +P +++ GE G P VP+ + A AK PQP
Sbjct: 1398 ---DGTGGMARAVAKAALSPVQEHETGRRSSSGEAGTPLVPIVVEPARPGAKAVVPQPL- 1453
Query: 2102 GGRPLEVLEKPVHLPRPGHPGPSEPADQKLSAVGEKQTLSPKHPKPSTVKDCP 2154
G + L++P L P L V E+ TLS KP++ K P
Sbjct: 1454 -GADSKGLQEPAPLAPSVPEAPRGRERWVLEVVEERTTLSGPRSKPASPKLSP 1505
Score = 38.9 bits (89), Expect = 0.062
Identities = 113/524 (21%), Positives = 180/524 (34%), Gaps = 112/524 (21%)
Query: 1525 SHECLPGNPVRPTGGQQEPPPASESRAFVSSTHAAQMSAVSFVPLKALTGRVDSGTEKPG 1584
S + LPG+P P S + ++ S+ +A + A S + P
Sbjct: 1120 SSDSLPGSPTHGL------PARSPTHSYRSTPDSAYLGA-------------SSQSSSPA 1160
Query: 1585 LVAPESPVRKSPSEYKLEGRSVSCLKPIEGTLDIALLSGPQASKTELPSPESAQSPSPSG 1644
P SP S + + + ++ L P L S S +P A +PSP+
Sbjct: 1161 SSTPNSPA--SSASHHIRPSTLHGLSP---KLHRQYRSARCKSAGNIPLSPLAHTPSPT- 1214
Query: 1645 DVRASVPPVLPSSSGKKNDTTS-------------------ARELSPSSLKMNKSYLLEP 1685
+AS PP+ + G + T S SP ++ + L
Sbjct: 1215 --QASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVRPRPKSAEPPRSPLLKRVQSAEKLGA 1272
Query: 1686 WFLPPSRGLQNSPAVSLPDPEFKRDRKGP---HPTARSPGTVMESNPQQREGSSPKHQDH 1742
+G ++ + P+F++D G H A S G E+ P + G+
Sbjct: 1273 SLSADKKGALRKHSLEVGHPDFRKDFHGELALHSLAESDG---ETPPVEGLGAP------ 1323
Query: 1743 TTDPKLLTCLGQNLHSPDLARPRCPLPPEASPSREKPGLRESSERGPPTARSERSAARAD 1802
+ + L R PL A P L E + R P +++ + S A
Sbjct: 1324 -----------RQVAVRRLGRQESPLSLGADPL-----LPEGASRPPVSSKEKESPGGA- 1366
Query: 1803 TCREPSMELCFPETAKTSDNSKNLLSVGRT-HPDFYTQ--TQAMEKAWAPGGKTNHKDGP 1859
E C P A T VG T H T+ T M +A A + P
Sbjct: 1367 -------EACTPPRATTPGGRTLERDVGCTRHQSVQTEDGTGGMARAVAKAALS-----P 1414
Query: 1860 GEARPPPRDNSSLHSAGIPCEKELGKVRRGVEPKPEALLARRSLQPPGIESEKSEKLSSF 1919
+ R +SS AG P + + R P +A++ QP G +S+ ++ +
Sbjct: 1415 VQEHETGRRSSS-GEAGTPLVPIVVEPAR---PGAKAVVP----QPLGADSKGLQEPAPL 1466
Query: 1920 PSLQKDGAKEPER------KEQPLQRHPSSIPPPPLTAKDLSSPA-ARQHCSSPSHASGR 1972
+ + ER +E+ P S P P + + +P+ A CS+PS A
Sbjct: 1467 APSVPEAPRGRERWVLEVVEERTTLSGPRSKPASPKLSPEPQTPSLAPAKCSAPSSAVTP 1526
Query: 1973 EP-------GAKPSTAEPSSSPQDPPKPVAAHSESSSHKPRPGP 2009
P G KP S P + P + S PGP
Sbjct: 1527 VPPASLLGSGTKPQVGLTSRCPAEAVPPAGLTKKGVSSPAPPGP 1570
Score = 35.8 bits (81), Expect = 0.53
Identities = 116/505 (22%), Positives = 176/505 (34%), Gaps = 102/505 (20%)
Query: 1618 IALLSGPQASKTELPSPESAQSP--SPSGDVRASVPPVLPSSSGKKNDTTSARELSPSS- 1674
++ L+ +S LP + P SP+ R++ +S + + S+ SP+S
Sbjct: 1111 LSSLNRSLSSSDSLPGSPTHGLPARSPTHSYRSTPDSAYLGASSQSSSPASSTPNSPASS 1170
Query: 1675 ----LKMNKSYLLEPWFLPPSRGLQNSPAVSLPDPEFKRDRKGPHPTARSPGTVMESNPQ 1730
++ + + L P R + A ++P P PT SP + P
Sbjct: 1171 ASHHIRPSTLHGLSPKLHRQYRSARCKSAGNIPLSPLAHT---PSPTQASPPPL----PG 1223
Query: 1731 QREGSSPKHQDHTTDPKLLTCLGQNLHS-PDLARPRCPLPPEASPSREKPGLR--ESSER 1787
GSS HTT LHS P + RPR P A P R P L+ +S+E+
Sbjct: 1224 HTVGSS-----HTTQS-----FPAKLHSSPPVVRPR---PKSAEPPRS-PLLKRVQSAEK 1269
Query: 1788 GPPTARSERSAARADTCREPSMELCFPETAKTSDNSKNLLSV----GRTHP--------- 1834
+ SA + R+ S+E+ P+ K L S+ G T P
Sbjct: 1270 ----LGASLSADKKGALRKHSLEVGHPDFRKDFHGELALHSLAESDGETPPVEGLGAPRQ 1325
Query: 1835 -------------DFYTQTQAMEKAWAPGGKTNHKDGPG--EARPPPRDNSSLHSAGIPC 1879
E A P + K+ PG EA PPR + G
Sbjct: 1326 VAVRRLGRQESPLSLGADPLLPEGASRPPVSSKEKESPGGAEACTPPRATTP---GGRTL 1382
Query: 1880 EKELGKVR-RGVEPKPEALLARRSLQPPGIESEKSEKLSSFPSLQKDGAKEPERKEQPLQ 1938
E+++G R + V+ + R++ + + + S + G +P +
Sbjct: 1383 ERDVGCTRHQSVQTEDGTGGMARAVAKAALSPVQEHETGRRSSSGEAGTPLVPIVVEPAR 1442
Query: 1939 RHPSSIPPPPLTA--KDLSSPAARQHCSSPSHASGRE---------------PGAKPSTA 1981
++ P PL A K L PA S P GRE P +KP++
Sbjct: 1443 PGAKAVVPQPLGADSKGLQEPAPLAP-SVPEAPRGRERWVLEVVEERTTLSGPRSKPASP 1501
Query: 1982 EPSSSPQDPPKPVAAHSESSSHKPRPGPDPGPPKTKHPDRSLSSQKPSVGATKGKEPATQ 2041
+ S PQ P A S SS P PP + S KP VG T
Sbjct: 1502 KLSPEPQTPSLAPAKCSAPSS-----AVTPVPPASLLG----SGTKPQVGLTSRCPAEAV 1552
Query: 2042 SLGGSSREGKGHSKSGPDVFPATPG 2066
G +++G PA PG
Sbjct: 1553 PPAGLTKKGVSS--------PAPPG 1569
>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
sapiens]
Length = 1309
Score = 1506 bits (3899), Expect = 0.0
Identities = 812/1347 (60%), Positives = 976/1347 (72%), Gaps = 101/1347 (7%)
Query: 1 MDESSILRRRGLQKELSLPRRGSLIDSQKWNCLVKRCRTSNRKSLIGNGQSPALPRPHSP 60
MDESS+LRRRGLQKELSLPRRG + CR+ NRKSL+ SP L RP SP
Sbjct: 1 MDESSLLRRRGLQKELSLPRRG------------RGCRSGNRKSLVVGTPSPTLSRPLSP 48
Query: 61 LSAH-AGNSPQDSPRNFSPSASAHFSFARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCS 119
LS AG+SP DSPRNFS +++ +F FARR DGRRWSLASLPSSGYGTNTPSST+SSS S
Sbjct: 49 LSVPTAGSSPLDSPRNFSAASALNFPFARRADGRRWSLASLPSSGYGTNTPSSTLSSSSS 108
Query: 120 SQEKLHQLPYQPTPDELHFLSKHFCTTESIATENRCRNTPMRPRSRSLSPGRSPACCDHE 179
S+E+LHQLP+QPTPDELHFLSKHF ++E++ E R+ +RPRSRSLSPGR+ D+E
Sbjct: 109 SRERLHQLPFQPTPDELHFLSKHFRSSENVLDEEGGRSPRLRPRSRSLSPGRATGTFDNE 168
Query: 180 IIMMNHVYKERFPKATAQMEERLKEIITSYSPDNVLPLADGVLSFTHHQIIELARDCLDK 239
I+MMNHVY+ERFPKATAQME RL+E +T+Y+P L LADGVL F HHQI+ELARDCL K
Sbjct: 169 IVMMNHVYRERFPKATAQMEGRLQEFLTAYAPGARLALADGVLGFIHHQIVELARDCLAK 228
Query: 240 SHQGLITSRYFLELQHKLDKLLQEAHDRSESGELAFIKQLVRKILIVIARPARLLECLEF 299
S + L+TSRYFLE+Q KL++LLQ+AH+RS+S E++FI QLVRK+LI+I+RPARLLECLEF
Sbjct: 229 SGENLVTSRYFLEMQEKLERLLQDAHERSDSEEVSFIVQLVRKLLIIISRPARLLECLEF 288
Query: 300 DPEEFYYLLEAAEGHAKEGQGIKTDIPRYIISQLGLNKDPLEEMAHLGNYDSGTAETPET 359
DPEEFY+LLEAAEGHA+EGQGIKTD+P+YII QLGL KDPLEEM L + + PE+
Sbjct: 289 DPEEFYHLLEAAEGHAREGQGIKTDLPQYIIGQLGLAKDPLEEMVPLSHLEEEQPPAPES 348
Query: 360 DESVSSSNASLKLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLIL 419
ES + S RRKP ESDFETIKLISNGAYGAVY VRH+++RQRFA+KKINKQNLIL
Sbjct: 349 PESRALVGQS---RRKPCESDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLIL 405
Query: 420 RNQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVD 479
RNQIQQ FVERDILTFAENPFVVSM+CSFETRRHLCMVMEYVEGGDCATL+KNMGPLPVD
Sbjct: 406 RNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVD 465
Query: 480 MARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYE 539
MAR+YFAETVLALEYLHNYGIVHRDLKPDNLL+TS+GHIKLTDFGLSK+GLMSM TNLYE
Sbjct: 466 MARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYE 525
Query: 540 GHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTP 599
GHIEKDAREF+DKQVCGTPEYIAPEVI RQGYGKPVDWWAMG++LYEFLVGCVPFFGDTP
Sbjct: 526 GHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTP 585
Query: 600 EELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDW 659
EELFGQV+SDEI WPE DEA P DAQDLIT LLRQ+PL+RLGTGG +EVKQH FF +LDW
Sbjct: 586 EELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDW 645
Query: 660 NSLLRQKAEFIPQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQFSSCSHRF 719
LLR KAEF+PQLE+EDDTSYFDTRSE+Y H+ + E+D+TNDE+ + EI QFSSCSHRF
Sbjct: 646 AGLLRHKAEFVPQLEAEDDTSYFDTRSERYRHLGS-EDDETNDEESSTEIPQFSSCSHRF 704
Query: 720 SKVFSSIDRIT---------QNSAEEKEDSVDKTK----STTLPSTETLSWSSEYSEMQQ 766
SKV+SS + + ++ +E++E+ ++++ SW+S S Q
Sbjct: 705 SKVYSSSEFLAVQPTPTFAERSFSEDREEGWERSEVDYGRRLSADIRLRSWTSSGSSCQS 764
Query: 767 LSTS-NSSDTESNRHKLSSGLLPKLAISTEGEQDEAASCPGDPHEEPGKPALPPEECAQE 825
S+ + S + +S +PK A S+E DE PG P P P
Sbjct: 765 SSSQPERGPSPSLLNTISLDTMPKFAFSSE---DEGVG-PG-----PAGPKRP--VFILG 813
Query: 826 EPEVTTPASTISSSTLSVGSFSEHLDQINGRSECVDSTDNSSKP-----------SSEPA 874
EP+ A+ + S+ + + L RS + + ++ +P +PA
Sbjct: 814 EPDPPPAATPVMPKPSSLSADTAALSHARLRSNSIGARHSTPRPLDAGRGRRLGGPRDPA 873
Query: 875 SHMARQRLESTEKKKISGKVTKSLSASALSLMIPGDMFAVSPLGSPMSPHSLSSDPSSSR 934
+R G+V KS S SALSL+I D + PL SP+SP SLSS+P SSR
Sbjct: 874 PEKSRASSSGGSGGGSGGRVPKSASVSALSLIITADDGSGGPLMSPLSPRSLSSNP-SSR 932
Query: 935 DSSPSRDSSAASASPHQPIVIHSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPA 994
DSSPSRD S S PIVIHSSGK YGF++RAIRVY+GDSD+YTVHH+VW+VE+GSPA
Sbjct: 933 DSSPSRDPSPVCGSLRPPIVIHSSGKKYGFSLRAIRVYMGDSDVYTVHHVVWSVEDGSPA 992
Query: 995 CQAGLKAGDLITHINGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTSIKTGPARRNSY 1054
+AGL+AGDLITHINGE V GLVH +V+ELLLKSGNK+S+ TT ENTSIK GPAR+N
Sbjct: 993 QEAGLRAGDLITHINGESVLGLVHMDVVELLLKSGNKISLRTTALENTSIKVGPARKNVA 1052
Query: 1055 KSRMVRRSKKSKKKESLERRRSLFKKLAKQPSPLLHTSRSFSC-LNRSLSSGESLPGSPT 1113
K RM RRSK+S+++E+ +RR+SLFKK++KQ S +LHTSRSFS L+ SLSS ESLPGSPT
Sbjct: 1053 KGRMARRSKRSRRRETQDRRKSLFKKISKQTS-VLHTSRSFSSGLHHSLSSSESLPGSPT 1111
Query: 1114 HSLSPRSPTPSYRSTPDFPSGTNSS-QSSSPSSSAPNSPAGSGHIRPSTLHGLAPKLGGQ 1172
HSLSP TP PD P+ T +S S+SPSSS+P SPA +GH RPS+LHGLA KLG
Sbjct: 1112 HSLSPSPTTPCRSPAPDVPADTTASPPSASPSSSSPASPAAAGHTRPSSLHGLAAKLGPP 1171
Query: 1173 RYRSGRRKSAGNIPLSPLARTPSPTPQPTSPQRSPSPLLGHSLGNSKIAQAFPSKMHSPP 1232
R ++GRRKS +IP SPLA P P P RSPSPL GH PP
Sbjct: 1172 RPKTGRRKSTSSIPPSPLACPPISAP----PPRSPSPLPGH-----------------PP 1210
Query: 1233 TIVRHIVRPKSAEPPRSPLLKRVQSEEKLSP-----------SYGSDKKHLCSRKHSLEV 1281
P RSP L+R QS +KL + G + + + R+ L
Sbjct: 1211 A------------PARSPRLRRGQSADKLGTGERLDGEAGRRTRGPEAELVVMRRLHLSE 1258
Query: 1282 TQEEVQREQSQREAPLQSLDENVCDVP 1308
++ +++++ +E E +P
Sbjct: 1259 RRDSFKKQEAVQEVSFDEPQEEATGLP 1285
Score = 42.0 bits (97), Expect = 0.007
Identities = 43/177 (24%), Positives = 69/177 (38%), Gaps = 12/177 (6%)
Query: 1887 RRGVEPKPEALLARRSLQPPGIESEKSEKLSSFPSLQKDGAK--EPERKEQPLQRHPSSI 1944
RR + + ++L + S Q + + +S SL + P P P
Sbjct: 1065 RRETQDRRKSLFKKISKQTSVLHTSRSFSSGLHHSLSSSESLPGSPTHSLSPSPTTPCRS 1124
Query: 1945 PPPPLTAKDLSSPAARQHCSSPSHASGREPGA----KPSTAEPSSSPQDPPKPVAAHSES 2000
P P + A +SP + +SPS +S P A +PS+ ++ PP+P +S
Sbjct: 1125 PAPDVPADTTASPPS----ASPSSSSPASPAAAGHTRPSSLHGLAAKLGPPRPKTGRRKS 1180
Query: 2001 SSHKPRPGPDPGPPKTKHPDRSLSSQKPSVGATKGKEPATQSLGGSSREGKGHSKSG 2057
+S P P P PP + P RS S P + P + + + G G G
Sbjct: 1181 TSSIP-PSPLACPPISAPPPRS-PSPLPGHPPAPARSPRLRRGQSADKLGTGERLDG 1235
Score = 32.7 bits (73), Expect = 4.5
Identities = 47/196 (23%), Positives = 66/196 (33%), Gaps = 30/196 (15%)
Query: 1782 RESSERGPPTARSERSAARADTCREPSMELCFPETAKTSDNSKNLLSVGRTHPDFYTQTQ 1841
R++ +G RS+RS R +T D K+L QT
Sbjct: 1048 RKNVAKGRMARRSKRSRRR-----------------ETQDRRKSLFK------KISKQTS 1084
Query: 1842 AMEKAWAPGGKTNHKDGPGEARPPPRDNSSLHSAGIPCEKELGKVRRGVEPKPEALLARR 1901
+ + + +H E+ P +S S PC V P + A
Sbjct: 1085 VLHTSRSFSSGLHHSLSSSESLPGSPTHSLSPSPTTPCRSPAPDVPADTTASPPS--ASP 1142
Query: 1902 SLQPPGIESEKSEKLSSFPSLQKDGAK-EPERKEQPLQRHPSSIPPPPLTAKDLSSPAAR 1960
S P + S SL AK P R + ++ SSIPP PL +S+P R
Sbjct: 1143 SSSSPASPAAAGHTRPS--SLHGLAAKLGPPRPKTGRRKSTSSIPPSPLACPPISAPPPR 1200
Query: 1961 QHCSSPSH--ASGREP 1974
P H A R P
Sbjct: 1201 SPSPLPGHPPAPARSP 1216
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 232 bits (592), Expect = 3e-60
Identities = 129/358 (36%), Positives = 198/358 (55%), Gaps = 31/358 (8%)
Query: 330 ISQLGLNKDPLEEMAHLGNYDSGTAETPETDESVSSSNASLKLRRKPRESDFETIKLISN 389
+ Q +DP++ Y G+ T E + A K R K +DF+ +KL+
Sbjct: 110 LKQRAPGEDPMD-------YKCGSPSDSSTTEEMEV--AVSKARAKVTMNDFDYLKLLGK 160
Query: 390 GAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFE 449
G +G V VR K + + +AMK + K+ +I ++++ E +L +PF+ ++ +F+
Sbjct: 161 GTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQ 220
Query: 450 TRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDN 509
T LC VMEY GG+ + + AR Y AE V ALEYLH+ +V+RD+K +N
Sbjct: 221 THDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLEN 280
Query: 510 LLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQ 569
L++ GHIK+TDFGL K G+ T K CGTPEY+APEV+
Sbjct: 281 LMLDKDGHIKITDFGLCKEGISDGATM---------------KTFCGTPEYLAPEVLEDN 325
Query: 570 GYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLIT 629
YG+ VDWW +G+++YE + G +PF+ E LF ++ +EI +P P+A+ L+
Sbjct: 326 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFP---RTLSPEAKSLLA 382
Query: 630 LLLRQNPLERLGTG--GAYEVKQHRFFRSLDWNSLLRQK--AEFIPQLESEDDTSYFD 683
LL+++P +RLG G A EV +HRFF S++W ++++K F PQ+ SE DT YFD
Sbjct: 383 GLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFD 440
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 228 bits (580), Expect = 7e-59
Identities = 127/355 (35%), Positives = 196/355 (55%), Gaps = 29/355 (8%)
Query: 334 GLNKDPLEEMAHLGNYDSGTAETPETDESVSSSNASLKLRRKPRESDFETIKLISNGAYG 393
GL K EEM S + E + S++ K + + ++FE +KL+ G +G
Sbjct: 109 GLKKQEEEEMDFRSGSPSDNSGAEEMEVSLA------KPKHRVTMNEFEYLKLLGKGTFG 162
Query: 394 AVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRH 453
V V+ K + + +AMK + K+ ++ ++++ E +L + +PF+ ++ SF+T
Sbjct: 163 KVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR 222
Query: 454 LCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHN-YGIVHRDLKPDNLLV 512
LC VMEY GG+ + D AR Y AE V AL+YLH+ +V+RDLK +NL++
Sbjct: 223 LCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML 282
Query: 513 TSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYG 572
GHIK+TDFGL K G+ T K CGTPEY+APEV+ YG
Sbjct: 283 DKDGHIKITDFGLCKEGIKDGATM---------------KTFCGTPEYLAPEVLEDNDYG 327
Query: 573 KPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLLL 632
+ VDWW +G+++YE + G +PF+ E+LF ++ +EI +P P+A+ L++ LL
Sbjct: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP---RTLGPEAKSLLSGLL 384
Query: 633 RQNPLERLGTGG--AYEVKQHRFFRSLDWNSLLRQKAE--FIPQLESEDDTSYFD 683
+++P +RLG G A E+ QHRFF + W + +K F PQ+ SE DT YFD
Sbjct: 385 KKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 439
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 228 bits (580), Expect = 7e-59
Identities = 127/355 (35%), Positives = 196/355 (55%), Gaps = 29/355 (8%)
Query: 334 GLNKDPLEEMAHLGNYDSGTAETPETDESVSSSNASLKLRRKPRESDFETIKLISNGAYG 393
GL K EEM S + E + S++ K + + ++FE +KL+ G +G
Sbjct: 109 GLKKQEEEEMDFRSGSPSDNSGAEEMEVSLA------KPKHRVTMNEFEYLKLLGKGTFG 162
Query: 394 AVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRH 453
V V+ K + + +AMK + K+ ++ ++++ E +L + +PF+ ++ SF+T
Sbjct: 163 KVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR 222
Query: 454 LCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHN-YGIVHRDLKPDNLLV 512
LC VMEY GG+ + D AR Y AE V AL+YLH+ +V+RDLK +NL++
Sbjct: 223 LCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML 282
Query: 513 TSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYG 572
GHIK+TDFGL K G+ T K CGTPEY+APEV+ YG
Sbjct: 283 DKDGHIKITDFGLCKEGIKDGATM---------------KTFCGTPEYLAPEVLEDNDYG 327
Query: 573 KPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLLL 632
+ VDWW +G+++YE + G +PF+ E+LF ++ +EI +P P+A+ L++ LL
Sbjct: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP---RTLGPEAKSLLSGLL 384
Query: 633 RQNPLERLGTGG--AYEVKQHRFFRSLDWNSLLRQKAE--FIPQLESEDDTSYFD 683
+++P +RLG G A E+ QHRFF + W + +K F PQ+ SE DT YFD
Sbjct: 385 KKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 439
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 228 bits (580), Expect = 7e-59
Identities = 127/355 (35%), Positives = 196/355 (55%), Gaps = 29/355 (8%)
Query: 334 GLNKDPLEEMAHLGNYDSGTAETPETDESVSSSNASLKLRRKPRESDFETIKLISNGAYG 393
GL K EEM S + E + S++ K + + ++FE +KL+ G +G
Sbjct: 109 GLKKQEEEEMDFRSGSPSDNSGAEEMEVSLA------KPKHRVTMNEFEYLKLLGKGTFG 162
Query: 394 AVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRH 453
V V+ K + + +AMK + K+ ++ ++++ E +L + +PF+ ++ SF+T
Sbjct: 163 KVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR 222
Query: 454 LCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHN-YGIVHRDLKPDNLLV 512
LC VMEY GG+ + D AR Y AE V AL+YLH+ +V+RDLK +NL++
Sbjct: 223 LCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML 282
Query: 513 TSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYG 572
GHIK+TDFGL K G+ T K CGTPEY+APEV+ YG
Sbjct: 283 DKDGHIKITDFGLCKEGIKDGATM---------------KTFCGTPEYLAPEVLEDNDYG 327
Query: 573 KPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLLL 632
+ VDWW +G+++YE + G +PF+ E+LF ++ +EI +P P+A+ L++ LL
Sbjct: 328 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP---RTLGPEAKSLLSGLL 384
Query: 633 RQNPLERLGTGG--AYEVKQHRFFRSLDWNSLLRQKAE--FIPQLESEDDTSYFD 683
+++P +RLG G A E+ QHRFF + W + +K F PQ+ SE DT YFD
Sbjct: 385 KKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 439
>gi|24307971 serine/threonine kinase 38 like [Homo sapiens]
Length = 464
Score = 226 bits (577), Expect = 2e-58
Identities = 129/370 (34%), Positives = 200/370 (54%), Gaps = 33/370 (8%)
Query: 380 DFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENP 439
DFE++K+I GA+G V V+ K++ +AMK + K +++ + Q+ ERDIL A+
Sbjct: 89 DFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGA 148
Query: 440 FVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYG 499
+VV M+ SF+ +R+L ++ME++ GGD TL+ L + + Y +ETVLA++ +H G
Sbjct: 149 WVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLG 208
Query: 500 IVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLY--------------------E 539
+HRD+KPDNLL+ + GH+KL+DFGL + T Y +
Sbjct: 209 FIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRK 268
Query: 540 GHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTP 599
K R L GTP+YIAPEV ++ GY K DWW++G+I+YE L+G PF +TP
Sbjct: 269 AETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETP 328
Query: 600 EELFGQVISDEINWPEKDEAPP--PDAQDLITLLLR--QNPLERLGTGGAYEVKQHRFFR 655
+E + +V +NW E PP P ++ L+LR + R+G G E+K H FF
Sbjct: 329 QETYRKV----MNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFE 384
Query: 656 SLDWNSLLRQKAEFIPQLESEDDTSYFD--TRSEKYHHMETEEEDDTNDEDF---NVEIR 710
+DW + + A +++S DDTS FD S+ + E D +D+ N +
Sbjct: 385 GVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDILQPVPNTTEPDYKSKDWVFLNYTYK 444
Query: 711 QFSSCSHRFS 720
+F + R S
Sbjct: 445 RFEGLTQRGS 454
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 226 bits (576), Expect = 2e-58
Identities = 118/321 (36%), Positives = 187/321 (58%), Gaps = 25/321 (7%)
Query: 381 FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF 440
FE IK + G++G V V+HKE+ +AMK ++KQ ++ QI+ E+ IL PF
Sbjct: 36 FERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 95
Query: 441 VVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGI 500
+V + SF+ +L MVMEYV GG+ + ++ +G AR Y A+ VL EYLH+ +
Sbjct: 96 LVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 155
Query: 501 VHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEY 560
++RDLKP+NLL+ G+I++TDFG +K + T L CGTPEY
Sbjct: 156 IYRDLKPENLLIDQQGYIQVTDFGFAK-RVKGRTWTL-----------------CGTPEY 197
Query: 561 IAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAP 620
+APE+IL +GY K VDWWA+G+++YE G PFF D P +++ +++S ++ +P +
Sbjct: 198 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSS- 256
Query: 621 PPDAQDLITLLLRQNPLERLGT--GGAYEVKQHRFFRSLDWNSLLRQKAE--FIPQLESE 676
D +DL+ LL+ + +R G G ++K H++F + DW ++ ++K E FIP+ +
Sbjct: 257 --DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGP 314
Query: 677 DDTSYFDTRSEKYHHMETEEE 697
DTS FD E+ + E+
Sbjct: 315 GDTSNFDDYEEEEIRVSINEK 335
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 226 bits (576), Expect = 2e-58
Identities = 118/321 (36%), Positives = 187/321 (58%), Gaps = 25/321 (7%)
Query: 381 FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF 440
FE IK + G++G V V+HKE+ +AMK ++KQ ++ QI+ E+ IL PF
Sbjct: 44 FERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 103
Query: 441 VVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGI 500
+V + SF+ +L MVMEYV GG+ + ++ +G AR Y A+ VL EYLH+ +
Sbjct: 104 LVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163
Query: 501 VHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEY 560
++RDLKP+NLL+ G+I++TDFG +K + T L CGTPEY
Sbjct: 164 IYRDLKPENLLIDQQGYIQVTDFGFAK-RVKGRTWTL-----------------CGTPEY 205
Query: 561 IAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAP 620
+APE+IL +GY K VDWWA+G+++YE G PFF D P +++ +++S ++ +P +
Sbjct: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSS- 264
Query: 621 PPDAQDLITLLLRQNPLERLGT--GGAYEVKQHRFFRSLDWNSLLRQKAE--FIPQLESE 676
D +DL+ LL+ + +R G G ++K H++F + DW ++ ++K E FIP+ +
Sbjct: 265 --DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGP 322
Query: 677 DDTSYFDTRSEKYHHMETEEE 697
DTS FD E+ + E+
Sbjct: 323 GDTSNFDDYEEEEIRVSINEK 343
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 226 bits (575), Expect = 3e-58
Identities = 131/361 (36%), Positives = 196/361 (54%), Gaps = 36/361 (9%)
Query: 367 NASLKLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQA 426
+AS ++ +DF+ +KL+ G +G V VR K S + +AMK + K+ +I ++++
Sbjct: 134 DASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHT 193
Query: 427 FVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFA 486
E +L +PF+ S+ SF+T+ LC VMEYV GG+ + D R Y A
Sbjct: 194 LTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGA 253
Query: 487 ETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDA 546
E V AL+YLH+ IV+RDLK +NL++ GHIK+TDFGL K G+ T
Sbjct: 254 EIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATM---------- 303
Query: 547 REFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQV 606
K CGTPEY+APEV+ YG+ VDWW +G+++YE + G +PF+ E+LF +
Sbjct: 304 -----KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI 358
Query: 607 ISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTG--GAYEVKQHRFFRSLDWNSLLR 664
+ ++I +P + DA+ L++ LL ++P +RLG G A E+ +H FF ++W +
Sbjct: 359 LMEDIKFPRTLSS---DAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415
Query: 665 QK--AEFIPQLESEDDTSYFD----------TRSEKYHHMETEEEDDTNDEDFNVEIRQF 712
+K F PQ+ SE DT YFD T EKY E+ D D + QF
Sbjct: 416 KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKY----DEDGMDCMDNERRPHFPQF 471
Query: 713 S 713
S
Sbjct: 472 S 472
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 224 bits (572), Expect = 6e-58
Identities = 121/321 (37%), Positives = 184/321 (57%), Gaps = 22/321 (6%)
Query: 367 NASLKLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQA 426
+AS ++ +DF+ +KL+ G +G V VR K S + +AMK + K+ +I ++++
Sbjct: 134 DASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHT 193
Query: 427 FVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFA 486
E +L +PF+ S+ SF+T+ LC VMEYV GG+ + D R Y A
Sbjct: 194 LTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGA 253
Query: 487 ETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDA 546
E V AL+YLH+ IV+RDLK +NL++ GHIK+TDFGL K G+ T
Sbjct: 254 EIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATM---------- 303
Query: 547 REFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQV 606
K CGTPEY+APEV+ YG+ VDWW +G+++YE + G +PF+ E+LF +
Sbjct: 304 -----KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI 358
Query: 607 ISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTG--GAYEVKQHRFFRSLDWNSLLR 664
+ ++I +P + DA+ L++ LL ++P +RLG G A E+ +H FF ++W +
Sbjct: 359 LMEDIKFPRTLSS---DAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415
Query: 665 QK--AEFIPQLESEDDTSYFD 683
+K F PQ+ SE DT YFD
Sbjct: 416 KKLVPPFKPQVTSETDTRYFD 436
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 223 bits (569), Expect = 1e-57
Identities = 120/332 (36%), Positives = 191/332 (57%), Gaps = 33/332 (9%)
Query: 361 ESVSSSNASLKLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILR 420
E+ + +NA L+ DFE K + G++G V V+HK + Q +AMK ++KQ ++
Sbjct: 32 ENPTQNNAGLE--------DFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKL 83
Query: 421 NQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDM 480
QI+ E+ IL PF+V + +F+ +L MVMEYV GG+ + ++ +G
Sbjct: 84 KQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 143
Query: 481 ARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEG 540
AR Y A+ VL EYLH+ +++RDLKP+NLL+ G+I++TDFG +K + T L
Sbjct: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK-RVKGRTWTL--- 199
Query: 541 HIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPE 600
CGTPEY+APE+IL +GY K VDWWA+G+++YE G PFF D P
Sbjct: 200 --------------CGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI 245
Query: 601 ELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGT--GGAYEVKQHRFFRSLD 658
+++ +++S ++ +P + D +DL+ LL+ + +R G G ++K H++F + D
Sbjct: 246 QIYEKIVSGKVRFPSHFSS---DLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTD 302
Query: 659 WNSLLRQKAE--FIPQLESEDDTSYFDTRSEK 688
W ++ ++K E FIP+ DTS FD E+
Sbjct: 303 WIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEE 334
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 223 bits (569), Expect = 1e-57
Identities = 120/332 (36%), Positives = 191/332 (57%), Gaps = 33/332 (9%)
Query: 361 ESVSSSNASLKLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILR 420
E+ + +NA L+ DFE K + G++G V V+HK + Q +AMK ++KQ ++
Sbjct: 79 ENPTQNNAGLE--------DFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKL 130
Query: 421 NQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDM 480
QI+ E+ IL PF+V + +F+ +L MVMEYV GG+ + ++ +G
Sbjct: 131 KQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 190
Query: 481 ARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEG 540
AR Y A+ VL EYLH+ +++RDLKP+NLL+ G+I++TDFG +K + T L
Sbjct: 191 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK-RVKGRTWTL--- 246
Query: 541 HIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPE 600
CGTPEY+APE+IL +GY K VDWWA+G+++YE G PFF D P
Sbjct: 247 --------------CGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI 292
Query: 601 ELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGT--GGAYEVKQHRFFRSLD 658
+++ +++S ++ +P + D +DL+ LL+ + +R G G ++K H++F + D
Sbjct: 293 QIYEKIVSGKVRFPSHFSS---DLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTD 349
Query: 659 WNSLLRQKAE--FIPQLESEDDTSYFDTRSEK 688
W ++ ++K E FIP+ DTS FD E+
Sbjct: 350 WIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEE 381
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 223 bits (567), Expect = 2e-57
Identities = 128/326 (39%), Positives = 189/326 (57%), Gaps = 25/326 (7%)
Query: 377 RESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFA 436
+ D+E +K+I GA+G V VRHK +R+ +AMK ++K +I R+ + ERDI+ FA
Sbjct: 72 KAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA 131
Query: 437 ENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLH 496
+P+VV ++ +F+ R+L MVMEY+ GGD LM N +P AR Y AE VLAL+ +H
Sbjct: 132 NSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDAIH 190
Query: 497 NYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCG 556
+ G +HRD+KPDN+L+ GH+KL DFG M M EG + D G
Sbjct: 191 SMGFIHRDVKPDNMLLDKSGHLKLADFGT----CMKMNK---EGMVRCDT-------AVG 236
Query: 557 TPEYIAPEVILRQG----YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVIS--DE 610
TP+YI+PEV+ QG YG+ DWW++G+ LYE LVG PF+ D+ + ++++ +
Sbjct: 237 TPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNS 296
Query: 611 INWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRS--LDWNSLLRQKAE 668
+ +P+ D +A++LI L + RLG G E+K+H FF++ W +L A
Sbjct: 297 LTFPD-DNDISKEAKNLICAFLTDREV-RLGRNGVEEIKRHLFFKNDQWAWETLRDTVAP 354
Query: 669 FIPQLESEDDTSYFDTRSEKYHHMET 694
+P L S+ DTS FD E ET
Sbjct: 355 VVPDLSSDIDTSNFDDLEEDKGEEET 380
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 221 bits (564), Expect = 5e-57
Identities = 120/338 (35%), Positives = 197/338 (58%), Gaps = 30/338 (8%)
Query: 357 PETDE----SVSSSNASLKLRRKPRESDFETIKLISNGAYGAVYFVRH---KESRQRFAM 409
P+T+E ++ ++ + K S FE +K++ G++G V+ V+ ++RQ +AM
Sbjct: 40 PQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAM 99
Query: 410 KKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATL 469
K + K L +R++++ +ERDIL +PF+V ++ +F+T L ++++++ GGD T
Sbjct: 100 KVLKKATLKVRDRVRTK-MERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTR 158
Query: 470 MKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVG 529
+ + + Y AE LAL++LH+ GI++RDLKP+N+L+ GHIKLTDFGLSK
Sbjct: 159 LSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKES 218
Query: 530 LMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLV 589
+ EK A F CGT EY+APEV+ R+G+ + DWW+ G++++E L
Sbjct: 219 I----------DHEKKAYSF-----CGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLT 263
Query: 590 GCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTG--GAYE 647
G +PF G +E ++ ++ P + P+AQ L+ +L ++NP RLG G G E
Sbjct: 264 GTLPFQGKDRKETMTMILKAKLGMP---QFLSPEAQSLLRMLFKRNPANRLGAGPDGVEE 320
Query: 648 VKQHRFFRSLDWNSLLRQKAE--FIPQLESEDDTSYFD 683
+K+H FF ++DWN L R++ F P +DT YFD
Sbjct: 321 IKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFD 358
Score = 103 bits (257), Expect = 2e-21
Identities = 75/272 (27%), Positives = 128/272 (47%), Gaps = 37/272 (13%)
Query: 381 FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF 440
+E + I G+Y HK + FA+K I+K +I+ +L + ++P
Sbjct: 422 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEI------LLRYGQHPN 475
Query: 441 VVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGI 500
++++ ++ +++ +V E ++GG+ + A +EYLH G+
Sbjct: 476 IITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGV 535
Query: 501 VHRDLKPDNLL-VTSMGH---IKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCG 556
VHRDLKP N+L V G+ I++ DFG +K + A L C
Sbjct: 536 VHRDLKPSNILYVDESGNPESIRICDFGFAK---------------QLRAENGLLMTPCY 580
Query: 557 TPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFG---DTPEELFGQVISDEIN- 612
T ++APEV+ RQGY D W++G++LY L G PF DTPEE+ ++ S + +
Sbjct: 581 TANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSL 640
Query: 613 ----WPEKDEAPPPDAQDLITLLLRQNPLERL 640
W + A+DL++ +L +P +RL
Sbjct: 641 SGGYWNSVSDT----AKDLVSKMLHVDPHQRL 668
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 219 bits (559), Expect = 2e-56
Identities = 120/317 (37%), Positives = 185/317 (58%), Gaps = 26/317 (8%)
Query: 375 KPRESDFETIKLISNGAYGAVYFVR---HKESRQRFAMKKINKQNLILRNQIQQAFVERD 431
K S FE +K++ G++G V+ VR +S +AMK + K L +R++++ +ERD
Sbjct: 65 KADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTK-MERD 123
Query: 432 ILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLA 491
IL +PFVV ++ +F+T L ++++++ GGD T + + + Y AE L
Sbjct: 124 ILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALG 183
Query: 492 LEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLD 551
L++LH+ GI++RDLKP+N+L+ GHIKLTDFGLSK + EK A F
Sbjct: 184 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI----------DHEKKAYSF-- 231
Query: 552 KQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEI 611
CGT EY+APEV+ RQG+ DWW+ G++++E L G +PF G +E ++ ++
Sbjct: 232 ---CGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKL 288
Query: 612 NWPEKDEAPPPDAQDLITLLLRQNPLERLGTG--GAYEVKQHRFFRSLDWNSLLRQ--KA 667
P + +AQ L+ L ++NP RLG+G GA E+K+H F+ ++DWN L R+ K
Sbjct: 289 GMP---QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKP 345
Query: 668 EFIPQLESEDDTSYFDT 684
F P + DDT YFDT
Sbjct: 346 PFKPAVAQPDDTFYFDT 362
Score = 107 bits (268), Expect = 1e-22
Identities = 81/284 (28%), Positives = 133/284 (46%), Gaps = 40/284 (14%)
Query: 387 ISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYC 446
I G+Y HK + +A+K I+K +I+ +L + ++P ++++
Sbjct: 433 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEI------LLRYGQHPNIITLKD 486
Query: 447 SFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLK 506
++ +H+ +V E + GG+ + A +EYLH+ G+VHRDLK
Sbjct: 487 VYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLK 546
Query: 507 PDNLL-VTSMGH---IKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIA 562
P N+L V G+ +++ DFG +K + A L C T ++A
Sbjct: 547 PSNILYVDESGNPECLRICDFGFAK---------------QLRAENGLLMTPCYTANFVA 591
Query: 563 PEVILRQGYGKPVDWWAMGIILYEFLVGCVPFF---GDTPEELFGQVISDEI-----NWP 614
PEV+ RQGY + D W++GI+LY L G PF DTPEE+ ++ S + NW
Sbjct: 592 PEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 651
Query: 615 EKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLD 658
E A+DL++ +L +P +RL A +V QH + D
Sbjct: 652 TVSET----AKDLVSKMLHVDPHQRL---TAKQVLQHPWVTQKD 688
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 219 bits (559), Expect = 2e-56
Identities = 120/317 (37%), Positives = 185/317 (58%), Gaps = 26/317 (8%)
Query: 375 KPRESDFETIKLISNGAYGAVYFVR---HKESRQRFAMKKINKQNLILRNQIQQAFVERD 431
K S FE +K++ G++G V+ VR +S +AMK + K L +R++++ +ERD
Sbjct: 56 KADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTK-MERD 114
Query: 432 ILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLA 491
IL +PFVV ++ +F+T L ++++++ GGD T + + + Y AE L
Sbjct: 115 ILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALG 174
Query: 492 LEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLD 551
L++LH+ GI++RDLKP+N+L+ GHIKLTDFGLSK + EK A F
Sbjct: 175 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI----------DHEKKAYSF-- 222
Query: 552 KQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEI 611
CGT EY+APEV+ RQG+ DWW+ G++++E L G +PF G +E ++ ++
Sbjct: 223 ---CGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKL 279
Query: 612 NWPEKDEAPPPDAQDLITLLLRQNPLERLGTG--GAYEVKQHRFFRSLDWNSLLRQ--KA 667
P + +AQ L+ L ++NP RLG+G GA E+K+H F+ ++DWN L R+ K
Sbjct: 280 GMP---QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKP 336
Query: 668 EFIPQLESEDDTSYFDT 684
F P + DDT YFDT
Sbjct: 337 PFKPAVAQPDDTFYFDT 353
Score = 107 bits (268), Expect = 1e-22
Identities = 81/284 (28%), Positives = 133/284 (46%), Gaps = 40/284 (14%)
Query: 387 ISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYC 446
I G+Y HK + +A+K I+K +I+ +L + ++P ++++
Sbjct: 424 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEI------LLRYGQHPNIITLKD 477
Query: 447 SFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLK 506
++ +H+ +V E + GG+ + A +EYLH+ G+VHRDLK
Sbjct: 478 VYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLK 537
Query: 507 PDNLL-VTSMGH---IKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIA 562
P N+L V G+ +++ DFG +K + A L C T ++A
Sbjct: 538 PSNILYVDESGNPECLRICDFGFAK---------------QLRAENGLLMTPCYTANFVA 582
Query: 563 PEVILRQGYGKPVDWWAMGIILYEFLVGCVPFF---GDTPEELFGQVISDEI-----NWP 614
PEV+ RQGY + D W++GI+LY L G PF DTPEE+ ++ S + NW
Sbjct: 583 PEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN 642
Query: 615 EKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLD 658
E A+DL++ +L +P +RL A +V QH + D
Sbjct: 643 TVSET----AKDLVSKMLHVDPHQRL---TAKQVLQHPWVTQKD 679
>gi|6005814 serine/threonine kinase 38 [Homo sapiens]
Length = 465
Score = 219 bits (559), Expect = 2e-56
Identities = 121/328 (36%), Positives = 184/328 (56%), Gaps = 28/328 (8%)
Query: 380 DFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENP 439
DFE++K+I GA+G V V+ K++ +AMK + K +++ + Q+ ERDIL A++
Sbjct: 88 DFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSL 147
Query: 440 FVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYG 499
+VV M+ SF+ + +L ++ME++ GGD TL+ L + + Y AETVLA++ +H G
Sbjct: 148 WVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLG 207
Query: 500 IVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLY--------------------E 539
+HRD+KPDNLL+ S GH+KL+DFGL + T Y +
Sbjct: 208 FIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRK 267
Query: 540 GHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTP 599
K R L GTP+YIAPEV ++ GY K DWW++G+I+YE L+G PF +TP
Sbjct: 268 AETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETP 327
Query: 600 EELFGQVISDEINWPEKDEAPP--PDAQDLITLLLR--QNPLERLGTGGAYEVKQHRFFR 655
+E + +V +NW E PP P ++ L+LR R+G G E+K + FF
Sbjct: 328 QETYKKV----MNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVEEIKSNSFFE 383
Query: 656 SLDWNSLLRQKAEFIPQLESEDDTSYFD 683
+DW + + A +++S DDTS FD
Sbjct: 384 GVDWEHIRERPAAISIEIKSIDDTSNFD 411
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 219 bits (559), Expect = 2e-56
Identities = 122/359 (33%), Positives = 201/359 (55%), Gaps = 30/359 (8%)
Query: 330 ISQLGLNKDPLEEMAHLGNYDSGTAETPETDESVSSSNASLKLRRKPRESDFETIKLISN 389
++ L + +P+EE +D G + V K + FE +K++
Sbjct: 28 VNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHVKEGY------EKADPAQFELLKVLGQ 81
Query: 390 GAYGAVYFVRHK---ESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYC 446
G++G V+ VR K ++ Q +AMK + K +L +R++++ +ERDIL +PF+V ++
Sbjct: 82 GSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTK-MERDILVEVNHPFIVKLHY 140
Query: 447 SFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLK 506
+F+T L ++++++ GGD T + + + Y AE LAL++LH GIV+RDLK
Sbjct: 141 AFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLK 200
Query: 507 PDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVI 566
P+N+L+ +GHIKLTDFGLSK + EK A F CGT EY+APEV+
Sbjct: 201 PENILLDEIGHIKLTDFGLSKESVDQ----------EKKAYSF-----CGTVEYMAPEVV 245
Query: 567 LRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQD 626
R+G+ + DWW+ G++++E L G +PF G E ++ ++ P+ A +AQ
Sbjct: 246 NRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSA---EAQS 302
Query: 627 LITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQKAE--FIPQLESEDDTSYFD 683
L+ +L ++NP RLG+ G E+K+H FF ++DW+ L +++ + F P DDT FD
Sbjct: 303 LLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFD 361
Score = 93.6 bits (231), Expect = 2e-18
Identities = 68/271 (25%), Positives = 123/271 (45%), Gaps = 37/271 (13%)
Query: 381 FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF 440
+E + I G+Y H + FA+K I+K +I+ ++ + ++P
Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEI------LMRYGQHPN 479
Query: 441 VVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGI 500
++++ F+ R++ +V + ++GG+ + A ++YLH G+
Sbjct: 480 IITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGV 539
Query: 501 VHRDLKPDNLLV----TSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCG 556
VHRDLKP N+L S I++ DFG +K + L C
Sbjct: 540 VHRDLKPSNILYMDESASADSIRICDFGFAK---------------QLRGENGLLLTPCY 584
Query: 557 TPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFF---GDTPEELFGQVISDEI-- 611
T ++APEV+++QGY D W++G++ Y L G PF DTPEE+ ++ + +
Sbjct: 585 TANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSL 644
Query: 612 ---NWPEKDEAPPPDAQDLITLLLRQNPLER 639
NW + A+DL++ +L +P +R
Sbjct: 645 SGGNWDNISDG----AKDLLSHMLHMDPHQR 671
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 218 bits (554), Expect = 8e-56
Identities = 128/371 (34%), Positives = 203/371 (54%), Gaps = 47/371 (12%)
Query: 316 KEGQGIKTDIPRYIISQLGLNKDPLEEMAHLGNYDSGTAETPETDESVSSSNASLKLRRK 375
+E QGI + P D +++M HL PE ++ S LK+
Sbjct: 339 REPQGISWESPL----------DEVDKMCHLPE--------PELNKERPSLQIKLKIE-- 378
Query: 376 PRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTF 435
DF K++ G++G V+ K++ Q FA+K + K +++ + ++ VE+ +L+
Sbjct: 379 ----DFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSL 434
Query: 436 A-ENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEY 494
A E+PF+ M+C+F+T+ +L VMEY+ GGD +++ + A Y AE +L L++
Sbjct: 435 AWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQF 494
Query: 495 LHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQV 554
LH+ GIV+RDLK DN+L+ GHIK+ DFG+ K ++ DA+
Sbjct: 495 LHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLG------------DAK---TNTF 539
Query: 555 CGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWP 614
CGTP+YIAPE++L Q Y VDWW+ G++LYE L+G PF G EELF + D +P
Sbjct: 540 CGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYP 599
Query: 615 EKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQKAE--FIPQ 672
E +A+DL+ L + P +RLG G +++QH FR ++W L R++ + F P+
Sbjct: 600 RWLE---KEAKDLLVKLFVREPEKRLGVRG--DIRQHPLFREINWEELERKEIDPPFRPK 654
Query: 673 LESEDDTSYFD 683
++S D S FD
Sbjct: 655 VKSPFDCSNFD 665
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 217 bits (552), Expect = 1e-55
Identities = 112/321 (34%), Positives = 185/321 (57%), Gaps = 25/321 (7%)
Query: 381 FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF 440
FE ++ + G++G V VRH+E+ +AMK +NKQ ++ Q++ E+ IL + PF
Sbjct: 44 FERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPF 103
Query: 441 VVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGI 500
+V + SF+ +L +VMEYV GG+ + ++ +G A Y A+ VLA++YLH+ +
Sbjct: 104 LVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDL 163
Query: 501 VHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEY 560
+HRDLKP+NLL+ G++++TDFG +K + T L CGTPEY
Sbjct: 164 IHRDLKPENLLIDQQGYLQVTDFGFAK-RVKGRTWTL-----------------CGTPEY 205
Query: 561 IAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAP 620
+APE+IL +GY K VDWWA+G+++YE VG PF+ D P +++ +++S + +P K +
Sbjct: 206 LAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSS- 264
Query: 621 PPDAQDLITLLLRQNPLERLGT--GGAYEVKQHRFFRSLDWNSLLRQKAE--FIPQLESE 676
D + L+ LL+ + +R G G ++K H++F + W ++ +K E FIP+
Sbjct: 265 --DLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGP 322
Query: 677 DDTSYFDTRSEKYHHMETEEE 697
D S FD E+ + E+
Sbjct: 323 GDASNFDDYEEEELRISINEK 343
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 216 bits (551), Expect = 2e-55
Identities = 121/330 (36%), Positives = 191/330 (57%), Gaps = 33/330 (10%)
Query: 377 RESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFA 436
+ D++ +K+I GA+G V VRHK S++ +AMK ++K +I R+ + ERDI+ FA
Sbjct: 88 KAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA 147
Query: 437 ENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLH 496
+P+VV ++ +F+ R+L MVMEY+ GGD LM N +P A+ Y AE VLAL+ +H
Sbjct: 148 NSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWAKFYTAEVVLALDAIH 206
Query: 497 NYGIVHRDLKPDNLLVTSMGHIKLTDFG----LSKVGLMSMTTNLYEGHIEKDAREFLDK 552
+ G++HRD+KPDN+L+ GH+KL DFG + + G++ T
Sbjct: 207 SMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDT----------------- 249
Query: 553 QVCGTPEYIAPEVILRQG----YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI- 607
GTP+YI+PEV+ QG YG+ DWW++G+ LYE LVG PF+ D+ + +++
Sbjct: 250 -AVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMD 308
Query: 608 -SDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRS--LDWNSLLR 664
+ + +PE D A++LI L + RLG G E++QH FF++ W+++
Sbjct: 309 HKNSLCFPE-DAEISKHAKNLICAFLTDREV-RLGRNGVEEIRQHPFFKNDQWHWDNIRE 366
Query: 665 QKAEFIPQLESEDDTSYFDTRSEKYHHMET 694
A +P+L S+ D+S FD + +ET
Sbjct: 367 TAAPVVPELSSDIDSSNFDDIEDDKGDVET 396
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 216 bits (551), Expect = 2e-55
Identities = 215/881 (24%), Positives = 366/881 (41%), Gaps = 91/881 (10%)
Query: 377 RESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFA 436
+ DFE +K+I GA+G V VR +++ Q FAMK ++K ++ R + ERD+L
Sbjct: 67 QRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKG 126
Query: 437 ENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNM-GPLPVDMARMYFAETVLALEYL 495
++ +V +++ +F+ +L +VM+Y GGD TL+ LP ++A+ Y AE VLA+ L
Sbjct: 127 DSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSL 186
Query: 496 HNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVC 555
H G VHRD+KPDN+L+ GHI+L DFG + + TN G ++
Sbjct: 187 HQLGYVHRDVKPDNVLLDVNGHIRLADFG----SCLRLNTN---GMVDSSV-------AV 232
Query: 556 GTPEYIAPEVI--LRQG---YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVIS-- 608
GTP+YI+PE++ + +G YG DWW++G+ YE L G PF+ ++ E +G++++
Sbjct: 233 GTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHE 292
Query: 609 DEINWPEKDEAPPPDAQDLI-TLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQKA 667
D + +P P AQDLI LL RQ ERLG GG + + H FF +DW L A
Sbjct: 293 DHLQFPPDVPDVPASAQDLIRQLLCRQE--ERLGRGGLDDFRNHPFFEGVDWERLASSTA 350
Query: 668 EFIPQLESEDDTSYFDTRSEKYHHMET---EEEDDTNDEDFNVEIRQFSSCSH---RFSK 721
+IP+L DTS FD + +H T + ++S SH S+
Sbjct: 351 PYIPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSE 410
Query: 722 VFSSIDRITQNSAEEKEDSVDKTKSTTLPSTETLSWSSEYSEMQQLSTSNSSDTESNRHK 781
+++++R Q +EK + K + E L +++ E++QL + ++ R +
Sbjct: 411 AWAALERKLQCLEQEKVELSRKHQ-------EALHAPTDHRELEQL----RKEVQTLRDR 459
Query: 782 LSSGLLPKLAISTEGEQDEAASCPGDPHEEPGKPALPPEECAQEEPEVTTPASTISSSTL 841
L L K ++S G P PG+ + +E + E+ + + +
Sbjct: 460 LPEMLRDKASLS---------QTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQ 510
Query: 842 SV----GSFSEHLDQINGRSECVDSTDNSSKP-SSEPASHMARQRLESTEKKKISGKVTK 896
+ G E L ++ E +T + ++ SS+ A QR + +S +VT+
Sbjct: 511 ELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQ 570
Query: 897 ---------SLSASALSLMIPGDMFAVSPLGSPMSPHSLSSDPSSSRDSSPSRDSSAASA 947
S+ A ++ + + P L + ++ R+ S S
Sbjct: 571 LQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSG 630
Query: 948 SPHQPIVIHSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQAGLKAGDLITH 1007
+ + + + + + E +A L D+++
Sbjct: 631 KEEALCQLQEENRRLSREQERLEAELAQEQ-ESKQRLEGERRETESNWEAQL--ADILSW 687
Query: 1008 INGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTSIKTGPAR--RNSYKSRMVRRSKKS 1065
+N E V L K++ N +T PAR + +K+R +++ + S
Sbjct: 688 VNDEKVSR-------GYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEAS 740
Query: 1066 KKKE-------SLERRRSLFKKLAKQPSPLLHTSRSFSCLNRSLSSGESLPGSPTHSLSP 1118
+ E + ++ L ++L + L R + + + L
Sbjct: 741 ARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREELRA 800
Query: 1119 RSPT---PSYRSTP--DFPSGTNSSQSSSPSSSAPNSPAGSGHIRPSTLHGLAPKLGGQR 1173
R P PS P F S S S G +RP L R
Sbjct: 801 RGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGAVFPR 860
Query: 1174 YRSGRRKSAGNIPLSPLART--PSPTPQPTSPQRSPSPLLG 1212
+ S +P P + T P P PT R S +LG
Sbjct: 861 APTANTASTEGLPAKPGSHTLRPRSFPSPTKCLRCTSLMLG 901
>gi|4826948 protein kinase, X-linked [Homo sapiens]
Length = 358
Score = 216 bits (550), Expect = 2e-55
Identities = 116/312 (37%), Positives = 185/312 (59%), Gaps = 25/312 (8%)
Query: 380 DFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENP 439
DF+T+ + G +G V+ V+ K ++ FA+K ++ ++I Q Q E+ +L +P
Sbjct: 48 DFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHP 107
Query: 440 FVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYG 499
F++ ++ ++ R L M+MEYV GG+ + ++N G Y AE + A+EYLH+
Sbjct: 108 FLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKE 167
Query: 500 IVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPE 559
IV+RDLKP+N+L+ GHIKLTDFG +K L+ T L CGTPE
Sbjct: 168 IVYRDLKPENILLDRDGHIKLTDFGFAK-KLVDRTWTL-----------------CGTPE 209
Query: 560 YIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEA 619
Y+APEVI +G+G+ VDWWA+GI+++E L G PFF D P ++ ++++ +I++P +
Sbjct: 210 YLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDF 269
Query: 620 PPPDAQDLITLLLRQNPLERLGT--GGAYEVKQHRFFRSLDWNSLLRQKAE--FIPQLES 675
+DLI LL + RLG GA +VK HR+FRS+DW ++ ++K + +P++
Sbjct: 270 ---HVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAG 326
Query: 676 EDDTSYFDTRSE 687
+ DTS F+T E
Sbjct: 327 DGDTSNFETYPE 338
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 216 bits (550), Expect = 2e-55
Identities = 121/342 (35%), Positives = 196/342 (57%), Gaps = 30/342 (8%)
Query: 353 TAETPETDESVSS----SNASLKLRRKPRESDFETIKLISNGAYGAVYFVRH---KESRQ 405
T +T E +E V S+ + K S FE +K++ G+YG V+ VR ++ Q
Sbjct: 35 TEDTAEEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQ 94
Query: 406 RFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGD 465
+AMK + K L +R++++ +ERDIL +PF+V ++ +F+T L ++++++ GGD
Sbjct: 95 LYAMKVLKKATLKVRDRVRSK-MERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGD 153
Query: 466 CATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGL 525
T + + + Y AE LAL++LH+ GI++RDLKP+N+L+ GHIK+TDFGL
Sbjct: 154 LFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGL 213
Query: 526 SKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILY 585
SK I+ D R + CGT EY+APEV+ R+G+ + DWW+ G++++
Sbjct: 214 SKEA------------IDHDKRAY---SFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMF 258
Query: 586 EFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTG-- 643
E L G +PF G +E ++ ++ P+ +AQ L+ L ++NP RLG G
Sbjct: 259 EMLTGSLPFQGKDRKETMALILKAKLGMPQFLSG---EAQSLLRALFKRNPCNRLGAGID 315
Query: 644 GAYEVKQHRFFRSLDWNSLLRQ--KAEFIPQLESEDDTSYFD 683
G E+K+H FF ++DWN+L R+ K F P + +DT +FD
Sbjct: 316 GVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFD 357
Score = 105 bits (261), Expect = 7e-22
Identities = 82/305 (26%), Positives = 141/305 (46%), Gaps = 43/305 (14%)
Query: 381 FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF 440
+E + I G+Y HK + +A+K I+K +I+ +L + ++P
Sbjct: 423 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEI------LLRYGQHPN 476
Query: 441 VVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGI 500
++++ ++ + + +VME + GG+ + A ++YLH+ G+
Sbjct: 477 IITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGV 536
Query: 501 VHRDLKPDNLLVT----SMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCG 556
VHRDLKP N+L S I++ DFG +K + A L C
Sbjct: 537 VHRDLKPSNILYRDESGSPESIRVCDFGFAK---------------QLRAGNGLLMTPCY 581
Query: 557 TPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFG---DTPEELFGQVISDEI-- 611
T ++APEV+ RQGY D W++GI+LY L G PF DTPEE+ ++ S +
Sbjct: 582 TANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYAL 641
Query: 612 ---NWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDW---NSLLRQ 665
NW +A A+D+++ +L +P +RL A +V +H + + ++ N L RQ
Sbjct: 642 SGGNWDSISDA----AKDVVSKMLHVDPHQRL---TAMQVLKHPWVVNREYLSPNQLSRQ 694
Query: 666 KAEFI 670
+
Sbjct: 695 DVHLV 699
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 216 bits (549), Expect = 3e-55
Identities = 115/316 (36%), Positives = 186/316 (58%), Gaps = 26/316 (8%)
Query: 375 KPRESDFETIKLISNGAYGAVYFVRH---KESRQRFAMKKINKQNLILRNQIQQAFVERD 431
K S FE +K++ G+YG V+ VR ++ Q +AMK + K L +R++++ +ERD
Sbjct: 53 KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSK-MERD 111
Query: 432 ILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLA 491
IL +PF+V ++ +F+T L ++++++ GGD T + + + Y AE LA
Sbjct: 112 ILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 171
Query: 492 LEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLD 551
L++LH+ GI++RDLKP+N+L+ GHIK+TDFGLSK I+ D R +
Sbjct: 172 LDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEA------------IDHDKRAY-- 217
Query: 552 KQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEI 611
CGT EY+APEV+ R+G+ + DWW+ G++++E L G +PF G +E ++ ++
Sbjct: 218 -SFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKL 276
Query: 612 NWPEKDEAPPPDAQDLITLLLRQNPLERLGTG--GAYEVKQHRFFRSLDWNSLLRQ--KA 667
P+ +AQ L+ L ++NP RLG G G E+K+H FF ++DWN+L R+ K
Sbjct: 277 GMPQFLSG---EAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKP 333
Query: 668 EFIPQLESEDDTSYFD 683
F P + +DT +FD
Sbjct: 334 PFKPAVGRPEDTFHFD 349
Score = 105 bits (261), Expect = 7e-22
Identities = 82/305 (26%), Positives = 141/305 (46%), Gaps = 43/305 (14%)
Query: 381 FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF 440
+E + I G+Y HK + +A+K I+K +I+ +L + ++P
Sbjct: 415 YEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEI------LLRYGQHPN 468
Query: 441 VVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGI 500
++++ ++ + + +VME + GG+ + A ++YLH+ G+
Sbjct: 469 IITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGV 528
Query: 501 VHRDLKPDNLLVT----SMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCG 556
VHRDLKP N+L S I++ DFG +K + A L C
Sbjct: 529 VHRDLKPSNILYRDESGSPESIRVCDFGFAK---------------QLRAGNGLLMTPCY 573
Query: 557 TPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFG---DTPEELFGQVISDEI-- 611
T ++APEV+ RQGY D W++GI+LY L G PF DTPEE+ ++ S +
Sbjct: 574 TANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYAL 633
Query: 612 ---NWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDW---NSLLRQ 665
NW +A A+D+++ +L +P +RL A +V +H + + ++ N L RQ
Sbjct: 634 SGGNWDSISDA----AKDVVSKMLHVDPHQRL---TAMQVLKHPWVVNREYLSPNQLSRQ 686
Query: 666 KAEFI 670
+
Sbjct: 687 DVHLV 691
>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
Length = 625
Score = 211 bits (538), Expect = 5e-54
Identities = 116/328 (35%), Positives = 177/328 (53%), Gaps = 25/328 (7%)
Query: 377 RESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFA 436
+ DFE +K+I GA+ V V+ K++ Q +AMK +NK +++ R ++ ERD+L
Sbjct: 67 QRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNG 126
Query: 437 ENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGP-LPVDMARMYFAETVLALEYL 495
+ ++ ++ +F+ +L +VMEY GGD TL+ G +P +MAR Y AE V+A++ +
Sbjct: 127 DRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSV 186
Query: 496 HNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVC 555
H G VHRD+KPDN+L+ GHI+L DFG + + + R +
Sbjct: 187 HRLGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AV 232
Query: 556 GTPEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI- 607
GTP+Y++PE++ G YG DWWA+G+ YE G PF+ D+ E +G+++
Sbjct: 233 GTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVH 292
Query: 608 -SDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQK 666
+ ++ P DE P +A+D I LL P RLG GGA + + H FF LDW+ L
Sbjct: 293 YKEHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFFFGLDWDGLRDSV 351
Query: 667 AEFIPQLESEDDTSYFDTRSEKYHHMET 694
F P E DT FD + MET
Sbjct: 352 PPFTPDFEGATDTCNFDLVEDGLTAMET 379
>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
sapiens]
Length = 624
Score = 211 bits (538), Expect = 5e-54
Identities = 116/328 (35%), Positives = 177/328 (53%), Gaps = 25/328 (7%)
Query: 377 RESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFA 436
+ DFE +K+I GA+ V V+ K++ Q +AMK +NK +++ R ++ ERD+L
Sbjct: 67 QRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNG 126
Query: 437 ENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGP-LPVDMARMYFAETVLALEYL 495
+ ++ ++ +F+ +L +VMEY GGD TL+ G +P +MAR Y AE V+A++ +
Sbjct: 127 DRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSV 186
Query: 496 HNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVC 555
H G VHRD+KPDN+L+ GHI+L DFG + + + R +
Sbjct: 187 HRLGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AV 232
Query: 556 GTPEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI- 607
GTP+Y++PE++ G YG DWWA+G+ YE G PF+ D+ E +G+++
Sbjct: 233 GTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVH 292
Query: 608 -SDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQK 666
+ ++ P DE P +A+D I LL P RLG GGA + + H FF LDW+ L
Sbjct: 293 YKEHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFFFGLDWDGLRDSV 351
Query: 667 AEFIPQLESEDDTSYFDTRSEKYHHMET 694
F P E DT FD + MET
Sbjct: 352 PPFTPDFEGATDTCNFDLVEDGLTAMET 379
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 116,748,652
Number of Sequences: 37866
Number of extensions: 7005109
Number of successful extensions: 52664
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 894
Number of HSP's successfully gapped in prelim test: 2067
Number of HSP's that attempted gapping in prelim test: 29932
Number of HSP's gapped (non-prelim): 19167
length of query: 2434
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2315
effective length of database: 13,741,464
effective search space: 31811489160
effective search space used: 31811489160
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.