Search of human proteins with 148539860

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148539860 protein tyrosine phosphatase, receptor type, T
isoform 2 precursor [Homo sapiens]
         (1441 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148539860 protein tyrosine phosphatase, receptor type, T isof...  2953   0.0  
gi|148539858 protein tyrosine phosphatase, receptor type, T isof...  2941   0.0  
gi|157419150 protein tyrosine phosphatase, receptor type, M isof...  1968   0.0  
gi|157419152 protein tyrosine phosphatase, receptor type, M isof...  1963   0.0  
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo...  1767   0.0  
gi|208431815 protein tyrosine phosphatase, receptor type, K isof...  1761   0.0  
gi|110735402 protein tyrosine phosphatase, receptor type, U isof...  1564   0.0  
gi|110735404 protein tyrosine phosphatase, receptor type, U isof...  1547   0.0  
gi|110735406 protein tyrosine phosphatase, receptor type, U isof...  1540   0.0  
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...   510   e-144
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...   510   e-144
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...   510   e-144
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...   510   e-144
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...   506   e-143
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...   506   e-143
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...   495   e-139
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...   495   e-139
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...   495   e-139
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...   480   e-135
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...   476   e-134
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo...   434   e-121
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor...   434   e-121
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo...   434   e-121
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor...   421   e-117
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo...   421   e-117
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p...   394   e-109
gi|194097398 protein tyrosine phosphatase, receptor type, G prec...   380   e-105
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo...   356   1e-97
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo...   356   1e-97
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo...   356   1e-97

>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
            precursor [Homo sapiens]
          Length = 1441

 Score = 2953 bits (7655), Expect = 0.0
 Identities = 1441/1441 (100%), Positives = 1441/1441 (100%)

Query: 1    MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTW 60
            MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTW
Sbjct: 1    MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTW 60

Query: 61   EKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGAL 120
            EKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGAL
Sbjct: 61   EKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGAL 120

Query: 121  NVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVD 180
            NVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVD
Sbjct: 121  NVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVD 180

Query: 181  EVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT 240
            EVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT
Sbjct: 181  EVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT 240

Query: 241  RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAV 300
            RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAV
Sbjct: 241  RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAV 300

Query: 301  GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV 360
            GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV
Sbjct: 301  GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV 360

Query: 361  LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY 420
            LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY
Sbjct: 361  LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY 420

Query: 421  NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT 480
            NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT
Sbjct: 421  NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT 480

Query: 481  EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG 540
            EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG
Sbjct: 481  EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG 540

Query: 541  KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPL 600
            KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPL
Sbjct: 541  KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPL 600

Query: 601  NETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS 660
            NETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS
Sbjct: 601  NETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS 660

Query: 661  LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV 720
            LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV
Sbjct: 661  LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV 720

Query: 721  RLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYY 780
            RLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYY
Sbjct: 721  RLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYY 780

Query: 781  LKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQ 840
            LKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQ
Sbjct: 781  LKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQ 840

Query: 841  PTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQ 900
            PTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQ
Sbjct: 841  PTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQ 900

Query: 901  TASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIAT 960
            TASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIAT
Sbjct: 901  TASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIAT 960

Query: 961  QGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEP 1020
            QGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEP
Sbjct: 961  QGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEP 1020

Query: 1021 LAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPI 1080
            LAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPI
Sbjct: 1021 LAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPI 1080

Query: 1081 VVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1140
            VVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI
Sbjct: 1081 VVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1140

Query: 1141 LEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLP 1200
            LEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLP
Sbjct: 1141 LEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLP 1200

Query: 1201 RNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADF 1260
            RNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADF
Sbjct: 1201 RNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADF 1260

Query: 1261 WRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRIC 1320
            WRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRIC
Sbjct: 1261 WRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRIC 1320

Query: 1321 NMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLN 1380
            NMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLN
Sbjct: 1321 NMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLN 1380

Query: 1381 GGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1440
            GGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS
Sbjct: 1381 GGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1440

Query: 1441 F 1441
            F
Sbjct: 1441 F 1441


>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
            precursor [Homo sapiens]
          Length = 1460

 Score = 2941 bits (7625), Expect = 0.0
 Identities = 1441/1460 (98%), Positives = 1441/1460 (98%), Gaps = 19/1460 (1%)

Query: 1    MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTW 60
            MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTW
Sbjct: 1    MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTW 60

Query: 61   EKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGAL 120
            EKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGAL
Sbjct: 61   EKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGAL 120

Query: 121  NVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVD 180
            NVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVD
Sbjct: 121  NVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVD 180

Query: 181  EVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT 240
            EVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT
Sbjct: 181  EVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT 240

Query: 241  RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAV 300
            RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAV
Sbjct: 241  RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAV 300

Query: 301  GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV 360
            GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV
Sbjct: 301  GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV 360

Query: 361  LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY 420
            LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY
Sbjct: 361  LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY 420

Query: 421  NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT 480
            NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT
Sbjct: 421  NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT 480

Query: 481  EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG 540
            EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG
Sbjct: 481  EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG 540

Query: 541  KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPL 600
            KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPL
Sbjct: 541  KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPL 600

Query: 601  NETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS 660
            NETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS
Sbjct: 601  NETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS 660

Query: 661  LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV 720
            LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV
Sbjct: 661  LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV 720

Query: 721  RLATK-------------------GASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIIL 761
            RLATK                   GASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIIL
Sbjct: 721  RLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIIL 780

Query: 762  LGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFS 821
            LGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFS
Sbjct: 781  LGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFS 840

Query: 822  SSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQM 881
            SSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQM
Sbjct: 841  SSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQM 900

Query: 882  KRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSD 941
            KRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSD
Sbjct: 901  KRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSD 960

Query: 942  YINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYW 1001
            YINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYW
Sbjct: 961  YINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYW 1020

Query: 1002 PDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATG 1061
            PDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATG
Sbjct: 1021 PDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATG 1080

Query: 1062 LLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRA 1121
            LLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRA
Sbjct: 1081 LLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRA 1140

Query: 1122 QRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQT 1181
            QRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQT
Sbjct: 1141 QRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQT 1200

Query: 1182 LNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHK 1241
            LNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHK
Sbjct: 1201 LNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHK 1260

Query: 1242 QPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQV 1301
            QPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQV
Sbjct: 1261 QPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQV 1320

Query: 1302 EFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLE 1361
            EFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLE
Sbjct: 1321 EFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLE 1380

Query: 1362 KWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMV 1421
            KWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMV
Sbjct: 1381 KWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMV 1440

Query: 1422 ETLEQYKFVYEVALEYLSSF 1441
            ETLEQYKFVYEVALEYLSSF
Sbjct: 1441 ETLEQYKFVYEVALEYLSSF 1460


>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
            precursor [Homo sapiens]
          Length = 1452

 Score = 1968 bits (5098), Expect = 0.0
 Identities = 945/1447 (65%), Positives = 1147/1447 (79%), Gaps = 42/1447 (2%)

Query: 23   ARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDQAVPTGSFMMVNSSGR 82
            A  ++ +GGC FDE YS CGYS + G + F WEQ+NT  KP  D  +P+GSFM+VN+SGR
Sbjct: 18   AAGETFSGGCLFDEPYSTCGYSQSEGDD-FNWEQVNTLTKPTSDPWMPSGSFMLVNASGR 76

Query: 83   ASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVV 142
              GQ+AHLLLP LKENDTHCIDFHY+ SS+  S PG LNVYVKVN GP GNP+WN+SG  
Sbjct: 77   PEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDP 136

Query: 143  TEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVE 202
            T  W +AELAISTFWP+FYQVIFE ++  GH GY+A+DEV+VL HPC + PHFLR+QNVE
Sbjct: 137  TRTWNRAELAISTFWPNFYQVIFEVIT-SGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVE 195

Query: 203  VNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSV 262
            VN GQ ATFQC A G+    D+LWLQ  + RD  L   +V + RRF A+ +V +T +R  
Sbjct: 196  VNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDA 255

Query: 263  SKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIIL 322
             KYRC+IR++GG G+SNYAEL+VKEPP PIAPP+L +VGATYLWI+ NANSI GDGPI+ 
Sbjct: 256  GKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVA 315

Query: 323  KEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTK 382
            +EVEY T +G+W +   VDS +YK+ HLDPD EYEI VLLTRPGEGGTG PGP L TRTK
Sbjct: 316  REVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTK 375

Query: 383  CADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVI- 441
            CADP+ GP+ +E+V++++RQ+T++WEPFGY VTRCHSYNLTV Y Y    Q+   EEV  
Sbjct: 376  CADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSW 435

Query: 442  -QTSSH--YTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPF 498
               +SH  +T+  L P+  + ++L+L NPEGR ES+EL+VQT+ED+PGAVP ESIQG  F
Sbjct: 436  DTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTF 495

Query: 499  EEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYP 558
            EEKI++QW+ P +T GVITLYEI YKAV S DP  DLS+Q G+V KL NETH LF GLYP
Sbjct: 496  EEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYP 555

Query: 559  GTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRG 618
            GTTYSFTI+ASTAKGFGPP T +  TKISAPSMP Y+ +TPLN+TD T+TVMLKPA SRG
Sbjct: 556  GTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRG 615

Query: 619  APVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQP 678
            APVSVYQ+VV+EER +++++  +I++C+ VP+ ++NAS L+S +YFAAE    +L   QP
Sbjct: 616  APVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQP 675

Query: 679  FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVEPE 738
            FT+GDNKTYNGYWN PL P KSY IYFQA S+ANGETKI+CV++ATKGA+T      EPE
Sbjct: 676  FTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKP-VPEPE 734

Query: 739  KQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREM 798
            KQ D+TVK+AGVIAG+L+F+II LGV+L +K+R          KLAKK+KET S  ++EM
Sbjct: 735  KQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKR----------KLAKKRKETMSSTRQEM 784

Query: 799  GPVASADKPTTKLSASRNDEGFS-SSSQDVNGFTDGSRGELSQPTLT------------- 844
              + ++   +     +  DE FS   + ++NG +  S    +  T T             
Sbjct: 785  TVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDE 844

Query: 845  -----------IQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEY 893
                       +Q+H Y+  +P ++ Y   Q  PAIRVADLLQHITQMK  +GYGFKEEY
Sbjct: 845  THTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEY 904

Query: 894  EALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHR 953
            E+  EGQ+A WD+AK+DENR KNRYGNII+YDHSRVRL  ++GD +SDYIN NYIDGYHR
Sbjct: 905  ESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHR 964

Query: 954  PRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKV 1013
            P HYIATQGPMQET+ DFWRM+W EN+ASI+MVTNLVEVGRVKC +YWPDDTE+Y DIKV
Sbjct: 965  PNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKV 1024

Query: 1014 TLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLN 1073
            TLIETE LAEYVIRTF V+K+G HEIRE+R FHFT WPDHGVP +ATGLLGFVRQVK  +
Sbjct: 1025 TLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKS 1084

Query: 1074 PPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQY 1133
            PP AGP+VVHCSAGAGRTGCFI ID MLDMAE EGVVDI+NCVRELR++RVN+VQTEEQY
Sbjct: 1085 PPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQY 1144

Query: 1134 VFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPED 1193
            VF+HDAILEACLCG+T++P  + RSLYY++++LDPQTNSSQIK+EF+TLN+VTP +R ED
Sbjct: 1145 VFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVED 1204

Query: 1194 CSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPL 1253
            CSI LLPRNH+KNR MD+LP DRCLPFLI++DGESSNYINAALMDS+KQP+AF+VTQHPL
Sbjct: 1205 CSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPL 1264

Query: 1254 PNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDII 1313
            PNTV DFWRLV DY+C+SVVMLN++D AQ C QYWPE     +GPIQVEFVSAD++EDII
Sbjct: 1265 PNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDII 1324

Query: 1314 HRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGR 1373
             RIFRI N ARPQDGYR+VQ  Q++GWP YRDTP SKRS LK++R+++KWQE+Y+G EGR
Sbjct: 1325 SRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGR 1384

Query: 1374 TVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEV 1433
            TVVHCLNGGGRSGTFCAI  VCEM++ Q  +DVFH VKTLRNNK NMV+ L+QYKF YEV
Sbjct: 1385 TVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEV 1444

Query: 1434 ALEYLSS 1440
            ALEYL+S
Sbjct: 1445 ALEYLNS 1451


>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
            precursor [Homo sapiens]
          Length = 1465

 Score = 1963 bits (5085), Expect = 0.0
 Identities = 945/1460 (64%), Positives = 1147/1460 (78%), Gaps = 55/1460 (3%)

Query: 23   ARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDQAVPTGSFMMVNSSGR 82
            A  ++ +GGC FDE YS CGYS + G + F WEQ+NT  KP  D  +P+GSFM+VN+SGR
Sbjct: 18   AAGETFSGGCLFDEPYSTCGYSQSEGDD-FNWEQVNTLTKPTSDPWMPSGSFMLVNASGR 76

Query: 83   ASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVV 142
              GQ+AHLLLP LKENDTHCIDFHY+ SS+  S PG LNVYVKVN GP GNP+WN+SG  
Sbjct: 77   PEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDP 136

Query: 143  TEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVE 202
            T  W +AELAISTFWP+FYQVIFE ++  GH GY+A+DEV+VL HPC + PHFLR+QNVE
Sbjct: 137  TRTWNRAELAISTFWPNFYQVIFEVIT-SGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVE 195

Query: 203  VNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSV 262
            VN GQ ATFQC A G+    D+LWLQ  + RD  L   +V + RRF A+ +V +T +R  
Sbjct: 196  VNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDA 255

Query: 263  SKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIIL 322
             KYRC+IR++GG G+SNYAEL+VKEPP PIAPP+L +VGATYLWI+ NANSI GDGPI+ 
Sbjct: 256  GKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVA 315

Query: 323  KEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTK 382
            +EVEY T +G+W +   VDS +YK+ HLDPD EYEI VLLTRPGEGGTG PGP L TRTK
Sbjct: 316  REVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTK 375

Query: 383  CADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVI- 441
            CADP+ GP+ +E+V++++RQ+T++WEPFGY VTRCHSYNLTV Y Y    Q+   EEV  
Sbjct: 376  CADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSW 435

Query: 442  -QTSSH--YTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPF 498
               +SH  +T+  L P+  + ++L+L NPEGR ES+EL+VQT+ED+PGAVP ESIQG  F
Sbjct: 436  DTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTF 495

Query: 499  EEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYP 558
            EEKI++QW+ P +T GVITLYEI YKAV S DP  DLS+Q G+V KL NETH LF GLYP
Sbjct: 496  EEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYP 555

Query: 559  GTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRG 618
            GTTYSFTI+ASTAKGFGPP T +  TKISAPSMP Y+ +TPLN+TD T+TVMLKPA SRG
Sbjct: 556  GTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRG 615

Query: 619  APVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQP 678
            APVSVYQ+VV+EER +++++  +I++C+ VP+ ++NAS L+S +YFAAE    +L   QP
Sbjct: 616  APVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQP 675

Query: 679  FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVEPE 738
            FT+GDNKTYNGYWN PL P KSY IYFQA S+ANGETKI+CV++ATKGA+T      EPE
Sbjct: 676  FTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKP-VPEPE 734

Query: 739  KQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREM 798
            KQ D+TVK+AGVIAG+L+F+II LGV+L +K+R          KLAKK+KET S  ++EM
Sbjct: 735  KQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKR----------KLAKKRKETMSSTRQEM 784

Query: 799  GPVASADKPTTKLSASRNDEGFS-SSSQDVNGFTDGSRGELSQPTLT------------- 844
              + ++   +     +  DE FS   + ++NG +  S    +  T T             
Sbjct: 785  TVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDP 844

Query: 845  ------------------------IQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQ 880
                                    +Q+H Y+  +P ++ Y   Q  PAIRVADLLQHITQ
Sbjct: 845  FVPTAILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQ 904

Query: 881  MKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHS 940
            MK  +GYGFKEEYE+  EGQ+A WD+AK+DENR KNRYGNII+YDHSRVRL  ++GD +S
Sbjct: 905  MKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNS 964

Query: 941  DYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRY 1000
            DYIN NYIDGYHRP HYIATQGPMQET+ DFWRM+W EN+ASI+MVTNLVEVGRVKC +Y
Sbjct: 965  DYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKY 1024

Query: 1001 WPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYAT 1060
            WPDDTE+Y DIKVTLIETE LAEYVIRTF V+K+G HEIRE+R FHFT WPDHGVP +AT
Sbjct: 1025 WPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHAT 1084

Query: 1061 GLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELR 1120
            GLLGFVRQVK  +PP AGP+VVHCSAGAGRTGCFI ID MLDMAE EGVVDI+NCVRELR
Sbjct: 1085 GLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELR 1144

Query: 1121 AQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQ 1180
            ++RVN+VQTEEQYVF+HDAILEACLCG+T++P  + RSLYY++++LDPQTNSSQIK+EF+
Sbjct: 1145 SRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFR 1204

Query: 1181 TLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSH 1240
            TLN+VTP +R EDCSI LLPRNH+KNR MD+LP DRCLPFLI++DGESSNYINAALMDS+
Sbjct: 1205 TLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSY 1264

Query: 1241 KQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQ 1300
            KQP+AF+VTQHPLPNTV DFWRLV DY+C+SVVMLN++D AQ C QYWPE     +GPIQ
Sbjct: 1265 KQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQ 1324

Query: 1301 VEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRL 1360
            VEFVSAD++EDII RIFRI N ARPQDGYR+VQ  Q++GWP YRDTP SKRS LK++R++
Sbjct: 1325 VEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQV 1384

Query: 1361 EKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNM 1420
            +KWQE+Y+G EGRTVVHCLNGGGRSGTFCAI  VCEM++ Q  +DVFH VKTLRNNK NM
Sbjct: 1385 DKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNM 1444

Query: 1421 VETLEQYKFVYEVALEYLSS 1440
            V+ L+QYKF YEVALEYL+S
Sbjct: 1445 VDLLDQYKFCYEVALEYLNS 1464


>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
            [Homo sapiens]
          Length = 1440

 Score = 1767 bits (4577), Expect = 0.0
 Identities = 846/1450 (58%), Positives = 1087/1450 (74%), Gaps = 21/1450 (1%)

Query: 1    MASLAALAL----SLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQ 56
            M + AA AL    +LLL    P L  A+ Q +AGGC+FD+    C Y   L  + F W  
Sbjct: 1    MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDL-YDDFEWVH 59

Query: 57   INTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSS 116
            ++  E   L   +P GS+M+V+SS    G+KA L LPT+KENDTHCIDF Y   S+   +
Sbjct: 60   VSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLN 119

Query: 117  PGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGY 176
            PG LN+ V+VN GP  NP+WNV+G     W++AELA+STFWP+ YQVIFE+    G  GY
Sbjct: 120  PGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGY 179

Query: 177  IAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTA 236
            IA+D+++VL++PC K+PHFLRL +VEVN GQNATFQCIA G+ + H+KLWLQ+ NG D  
Sbjct: 180  IAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIP 239

Query: 237  LMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE 296
            +  T+ +NHRRF+A+  + +  +     YRCV +S+ GSGVSN+A+LIV+EPP PIAPP+
Sbjct: 240  VAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQ 299

Query: 297  LLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEY 356
            LL VG TYL I+ NANSIIGDGPIILKEVEYR T+G+W ETH V++P YKLWHLDPD EY
Sbjct: 300  LLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEY 359

Query: 357  EIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTR 416
            EIRVLLTRPGEGGTG PGPPL TRTKCA+P+  P+ ++I +I+AR++ + WE  GY +TR
Sbjct: 360  EIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITR 419

Query: 417  CHSYNLTVQYQYV--FNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE 474
            CH++N+T+ Y Y    N+ + +  ++   +  + +  L P+  + L+++L+NPEGR ESE
Sbjct: 420  CHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESE 479

Query: 475  ELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSAD 534
            E ++QT+EDVPG VP++S+QG  FE KI++ WK P + NG+IT YEI+Y ++ S DP+  
Sbjct: 480  ETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVP 539

Query: 535  LSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEY 594
            ++     V  L N THH+F+ L+PGTTY F I+AST KGFGP     + T ISAP++P+Y
Sbjct: 540  VAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDY 599

Query: 595  D-TDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
            +  D  LNET TTITV+L+PAQ++GAP+S YQ+VV+E    +++R A  +EC+ VPV+Y+
Sbjct: 600  EGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQ 659

Query: 654  NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713
            NA S  + +YFAAEL P NLP   PFTVGDN+TY G+WNPPL+P K Y+IYFQA+S    
Sbjct: 660  NAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEK 719

Query: 714  ETKINCVRLATKGASTQNSNTV-EPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRR 772
            ETK  CVR+ATK A+T+    + +P KQ D  VK+AG+ AG+L+FI++LL V+L +K+  
Sbjct: 720  ETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKS- 778

Query: 773  NAYSYSYYLKLAKKQKETQSGAQREMGPVASA-DKPTTKLSASRNDEGFSSSSQDVNGFT 831
                     KLAKK+K+     ++EM  + +A D+     S    ++  S +  D + F+
Sbjct: 779  ---------KLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFS 829

Query: 832  DGSRGE-LSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFK 890
                    +  +  +   P   C+  E  Y   Q  PAIRVADLLQHI  MK    YGFK
Sbjct: 830  PRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFK 889

Query: 891  EEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDG 950
            EEYE+  EGQ+ASWD AK+D+NR KNRYGNII+YDHSRV L  ++ DP SDYINANYIDG
Sbjct: 890  EEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDG 949

Query: 951  YHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGD 1010
            Y RP HYIATQGP+ ETV DFWRMIWQE SA IVMVTNLVEVGRVKC +YWPDDTEVYGD
Sbjct: 950  YQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGD 1009

Query: 1011 IKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVK 1070
             KVT +E EPLAEYV+RTFT++++GY+EIRE++ FHFT WPDHGVP +ATGLL F+R+VK
Sbjct: 1010 FKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVK 1069

Query: 1071 FLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTE 1130
              NPP AGPIVVHCSAGAGRTGC+I ID MLDMAE EGVVDI+NCV+ LR++R+N+VQTE
Sbjct: 1070 LSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTE 1129

Query: 1131 EQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVR 1190
            EQY+F+HDAILEACLCG TAIPVCEF++ Y+++ R+D QTNSS +KDEFQTLN VTPR++
Sbjct: 1130 EQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQ 1189

Query: 1191 PEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQ 1250
             EDCSI  LPRNHDKNR MD+LP DRCLPFLI++DGESSNYINAALMDS++QPAAF+VTQ
Sbjct: 1190 AEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQ 1249

Query: 1251 HPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDE 1310
            +PLPNTV DFWRLV+DY C+S+VMLNE+D +Q C QYWPE+    YGPIQVE +S  +D 
Sbjct: 1250 YPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDC 1309

Query: 1311 DIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGR 1370
            D+I+RIFRICN+ RPQ+GY +VQ  QY+GW ++R+ P SKRS LK++ ++EKWQE+ +  
Sbjct: 1310 DVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEG 1369

Query: 1371 EGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFV 1430
            EGRT++HCLNGGGRSG FCAI  V EM+++QN++DVFH VKTLRN+K NMVE  EQY+F 
Sbjct: 1370 EGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFC 1429

Query: 1431 YEVALEYLSS 1440
            Y+VALEYL S
Sbjct: 1430 YDVALEYLES 1439


>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
            [Homo sapiens]
          Length = 1446

 Score = 1761 bits (4560), Expect = 0.0
 Identities = 846/1456 (58%), Positives = 1087/1456 (74%), Gaps = 27/1456 (1%)

Query: 1    MASLAALAL----SLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQ 56
            M + AA AL    +LLL    P L  A+ Q +AGGC+FD+    C Y   L  + F W  
Sbjct: 1    MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDL-YDDFEWVH 59

Query: 57   INTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSS 116
            ++  E   L   +P GS+M+V+SS    G+KA L LPT+KENDTHCIDF Y   S+   +
Sbjct: 60   VSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLN 119

Query: 117  PGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGY 176
            PG LN+ V+VN GP  NP+WNV+G     W++AELA+STFWP+ YQVIFE+    G  GY
Sbjct: 120  PGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGY 179

Query: 177  IAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTA 236
            IA+D+++VL++PC K+PHFLRL +VEVN GQNATFQCIA G+ + H+KLWLQ+ NG D  
Sbjct: 180  IAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIP 239

Query: 237  LMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE 296
            +  T+ +NHRRF+A+  + +  +     YRCV +S+ GSGVSN+A+LIV+EPP PIAPP+
Sbjct: 240  VAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQ 299

Query: 297  LLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEY 356
            LL VG TYL I+ NANSIIGDGPIILKEVEYR T+G+W ETH V++P YKLWHLDPD EY
Sbjct: 300  LLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEY 359

Query: 357  EIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTR 416
            EIRVLLTRPGEGGTG PGPPL TRTKCA+P+  P+ ++I +I+AR++ + WE  GY +TR
Sbjct: 360  EIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITR 419

Query: 417  CHSYNLTVQYQYV--FNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE 474
            CH++N+T+ Y Y    N+ + +  ++   +  + +  L P+  + L+++L+NPEGR ESE
Sbjct: 420  CHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESE 479

Query: 475  ELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSAD 534
            E ++QT+EDVPG VP++S+QG  FE KI++ WK P + NG+IT YEI+Y ++ S DP+  
Sbjct: 480  ETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVP 539

Query: 535  LSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEY 594
            ++     V  L N THH+F+ L+PGTTY F I+AST KGFGP     + T ISAP++P+Y
Sbjct: 540  VAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDY 599

Query: 595  D-TDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
            +  D  LNET TTITV+L+PAQ++GAP+S YQ+VV+E    +++R A  +EC+ VPV+Y+
Sbjct: 600  EGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQ 659

Query: 654  NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713
            NA S  + +YFAAEL P NLP   PFTVGDN+TY G+WNPPL+P K Y+IYFQA+S    
Sbjct: 660  NAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEK 719

Query: 714  ETKINCVRLATKGASTQNSNTV-EPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRR 772
            ETK  CVR+ATK A+T+    + +P KQ D  VK+AG+ AG+L+FI++LL V+L +K+  
Sbjct: 720  ETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKS- 778

Query: 773  NAYSYSYYLKLAKKQKETQSGAQREMGPVASA-DKPTTKLSASRNDEGFSSSSQDVNGFT 831
                     KLAKK+K+     ++EM  + +A D+     S    ++  S +  D + F+
Sbjct: 779  ---------KLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFS 829

Query: 832  DGSRGE-LSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFK 890
                    +  +  +   P   C+  E  Y   Q  PAIRVADLLQHI  MK    YGFK
Sbjct: 830  PRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFK 889

Query: 891  EEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYID- 949
            EEYE+  EGQ+ASWD AK+D+NR KNRYGNII+YDHSRV L  ++ DP SDYINANYID 
Sbjct: 890  EEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDI 949

Query: 950  -----GYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD 1004
                 GY RP HYIATQGP+ ETV DFWRMIWQE SA IVMVTNLVEVGRVKC +YWPDD
Sbjct: 950  WLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDD 1009

Query: 1005 TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLG 1064
            TEVYGD KVT +E EPLAEYV+RTFT++++GY+EIRE++ FHFT WPDHGVP +ATGLL 
Sbjct: 1010 TEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLS 1069

Query: 1065 FVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRV 1124
            F+R+VK  NPP AGPIVVHCSAGAGRTGC+I ID MLDMAE EGVVDI+NCV+ LR++R+
Sbjct: 1070 FIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRI 1129

Query: 1125 NLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNI 1184
            N+VQTEEQY+F+HDAILEACLCG TAIPVCEF++ Y+++ R+D QTNSS +KDEFQTLN 
Sbjct: 1130 NMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNS 1189

Query: 1185 VTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPA 1244
            VTPR++ EDCSI  LPRNHDKNR MD+LP DRCLPFLI++DGESSNYINAALMDS++QPA
Sbjct: 1190 VTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPA 1249

Query: 1245 AFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFV 1304
            AF+VTQ+PLPNTV DFWRLV+DY C+S+VMLNE+D +Q C QYWPE+    YGPIQVE +
Sbjct: 1250 AFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECM 1309

Query: 1305 SADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQ 1364
            S  +D D+I+RIFRICN+ RPQ+GY +VQ  QY+GW ++R+ P SKRS LK++ ++EKWQ
Sbjct: 1310 SCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQ 1369

Query: 1365 EQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETL 1424
            E+ +  EGRT++HCLNGGGRSG FCAI  V EM+++QN++DVFH VKTLRN+K NMVE  
Sbjct: 1370 EECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAP 1429

Query: 1425 EQYKFVYEVALEYLSS 1440
            EQY+F Y+VALEYL S
Sbjct: 1430 EQYRFCYDVALEYLES 1445


>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
            precursor [Homo sapiens]
          Length = 1446

 Score = 1564 bits (4049), Expect = 0.0
 Identities = 758/1452 (52%), Positives = 1019/1452 (70%), Gaps = 26/1452 (1%)

Query: 1    MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSN---CGYSVALGTNGFTWEQI 57
            MA   AL L+L  +L  P       ++ A GC+F+E       C YS A   + F WEQ+
Sbjct: 1    MARAQALVLALTFQLCAP-----ETETPAAGCTFEEASDPAVPCEYSQAQ-YDDFQWEQV 54

Query: 58   NTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSP 117
                       +P GS++MVN+S  A GQ+AH++  +L ENDTHC+ F Y+  SRD  SP
Sbjct: 55   RIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSP 114

Query: 118  GALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYI 177
            G L VYV+VNGGP G+ VWN++G     W +AELA+STFWP+ YQV+FE++      GY+
Sbjct: 115  GTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYM 174

Query: 178  AVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTAL 237
             +D++ +L++PC KAPHF RL +VEVN GQNA+FQC+A G+ ++ ++  LQ+ +G     
Sbjct: 175  GLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPA 234

Query: 238  MVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPEL 297
               R ++HRRF AT  +A  ++     YRCV ++  G+GVSN+AELIVKEPPTPIAPP+L
Sbjct: 235  AGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQL 294

Query: 298  LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357
            L  G TYL I+ N NSIIGDGPI+ KE+EYR   G WAE H V    YKLWHLDPD EYE
Sbjct: 295  LRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYE 354

Query: 358  IRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRC 417
            I VLLTRPG+GGTG PGPPL +RTKCA+P+  P+ +   +I+ARQLTLQWEP GY VTRC
Sbjct: 355  ISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRC 414

Query: 418  HSYNLTVQYQYVF----NQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMES 473
            H+Y +++ Y Y      NQ   E  +  Q  S YT++ L P+  + +RL+L+NPEGR E 
Sbjct: 415  HTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEG 474

Query: 474  EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSA 533
            +E+  QT+EDVP  +  ES+   P E+ I+++W+ P E NG+IT YEI+Y+++ S DP+ 
Sbjct: 475  KEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAV 534

Query: 534  DLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPE 593
            ++   R  + KLRNET+H+F  L+PGTTY F+++A T KGFG    T I T ISAPS   
Sbjct: 535  NVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDY 594

Query: 594  YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
             D  +PL E++ TITV+L+PAQ RGAP+SVYQ++V+EER ++ RR     +CF VP+++ 
Sbjct: 595  ADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFE 654

Query: 654  NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713
             A +   +HYF AEL  ++LP   PFTVGDN+TY G+WNPPL P K+Y IYFQA S   G
Sbjct: 655  AALARGLVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKG 714

Query: 714  ETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRR-R 772
            ET++NC+R+A K A  ++   +E  ++ +    + G+ AG L  +I+LLG ++ I R+ R
Sbjct: 715  ETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGR 774

Query: 773  NAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFT- 831
            + Y+YSYY K     K T +  Q +   +++ D+  T  S  + DE    S  D +G++ 
Sbjct: 775  DHYAYSYYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYST 834

Query: 832  --DGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGF 889
              D   G +++ +  +   P R C      Y   Q  PA+RVADLLQHI QMK  +GYGF
Sbjct: 835  RGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGF 894

Query: 890  KEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYID 949
            K+EYE+  EG    WD  K+ +    +R   + +YD  RV+L  + GDP++DYINANYID
Sbjct: 895  KQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYID 950

Query: 950  GYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYG 1009
            GYHR  H+IATQGP  E V DFWRM+WQE+ +SIVM+T LVEVGRVKC RYWP+D++ YG
Sbjct: 951  GYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYG 1010

Query: 1010 DIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQV 1069
            DIK+ L++TE LAEYV+RTF ++++GY    E+R FHFT+WP+HGVP +ATGLL F+R+V
Sbjct: 1011 DIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRV 1070

Query: 1070 KFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQT 1129
            K   PP+AGPIV+HCSAG GRTGC+I +D MLDMAE EGVVDI+NCV+ L ++RVN++QT
Sbjct: 1071 KASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQT 1130

Query: 1130 EEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRV 1189
            EEQY+F+HDAILEACLCG T IPV EF++ Y  + R+DPQ+NSSQ+++EFQTLN VTP +
Sbjct: 1131 EEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPL 1190

Query: 1190 RPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVT 1249
              E+CSI LLPRN DKNRSMDVLP DRCLPFLIS DG+S+NYINAAL DS+ + AAF+VT
Sbjct: 1191 DVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVT 1250

Query: 1250 QHPLPNTVADFWRLVFDYNCSSVVMLNEM---DTAQFCMQYWPEKTSGCYGPIQVEFVSA 1306
             HPL +T  DFWRLV+DY C+S+VMLN++   ++A  C+QYWPE     YG ++VEF+S 
Sbjct: 1251 LHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSG 1310

Query: 1307 DIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQ 1366
              DED++ R+FR+ N++R Q+G+ +V+H Q++ W AYRDTP SK++ L ++  ++KWQ  
Sbjct: 1311 TADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQA- 1369

Query: 1367 YDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQ 1426
             +  +GRT+VHCLNGGGRSGTFCA  +V EMI+  N++DVF   KTLRN K NMVET++Q
Sbjct: 1370 -ESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQ 1428

Query: 1427 YKFVYEVALEYL 1438
            Y F Y+VALEYL
Sbjct: 1429 YHFCYDVALEYL 1440


>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
            precursor [Homo sapiens]
          Length = 1436

 Score = 1547 bits (4005), Expect = 0.0
 Identities = 752/1451 (51%), Positives = 1011/1451 (69%), Gaps = 34/1451 (2%)

Query: 1    MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSN---CGYSVALGTNGFTWEQI 57
            MA   AL L+L  +L  P       ++ A GC+F+E       C YS A   + F WEQ+
Sbjct: 1    MARAQALVLALTFQLCAP-----ETETPAAGCTFEEASDPAVPCEYSQAQ-YDDFQWEQV 54

Query: 58   NTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSP 117
                       +P GS++MVN+S  A GQ+AH++  +L ENDTHC+ F Y+  SRD  SP
Sbjct: 55   RIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSP 114

Query: 118  GALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYI 177
            G L VYV+VNGGP G+ VWN++G     W +AELA+STFWP+ YQV+FE++      GY+
Sbjct: 115  GTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYM 174

Query: 178  AVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTAL 237
             +D++ +L++PC KAPHF RL +VEVN GQNA+FQC+A G+ ++ ++  LQ+ +G     
Sbjct: 175  GLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPA 234

Query: 238  MVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPEL 297
               R ++HRRF AT  +A  ++     YRCV ++  G+GVSN+AELIVKEPPTPIAPP+L
Sbjct: 235  AGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQL 294

Query: 298  LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357
            L  G TYL I+ N NSIIGDGPI+ KE+EYR   G WAE H V    YKLWHLDPD EYE
Sbjct: 295  LRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYE 354

Query: 358  IRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRC 417
            I VLLTRPG+GGTG PGPPL +RTKCA+P+  P+ +   +I+ARQLTLQWEP GY VTRC
Sbjct: 355  ISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRC 414

Query: 418  HSYNLTVQYQYVF----NQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMES 473
            H+Y +++ Y Y      NQ   E  +  Q  S YT++ L P+  + +RL+L+NPEGR E 
Sbjct: 415  HTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEG 474

Query: 474  EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSA 533
            +E+  QT+EDVP  +  ES+   P E+ I+++W+ P E NG+IT YEI+Y+++ S DP+ 
Sbjct: 475  KEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAV 534

Query: 534  DLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPE 593
            ++   R  + KLRNET+H+F  L+PGTTY F+++A T KGFG    T I T ISAPS   
Sbjct: 535  NVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDY 594

Query: 594  YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
             D  +PL E++ TITV+L+PAQ RGAP+SVYQ++V+EER ++ RR     +CF VP+++ 
Sbjct: 595  ADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFE 654

Query: 654  NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713
             A +   +HYF AEL  ++LP   PFTVGDN+TY G+WNPPL P K+Y IYFQA S   G
Sbjct: 655  AALARGLVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKG 714

Query: 714  ETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRN 773
            ET++NC+R+A K A  ++   +E  ++ +    + G+ AG L  +I+LLG ++ I R+  
Sbjct: 715  ETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKG- 773

Query: 774  AYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFT-- 831
                    K     K T +  Q +   +++ D+  T  S  + DE    S  D +G++  
Sbjct: 774  --------KPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTR 825

Query: 832  -DGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFK 890
             D   G +++ +  +   P R C      Y   Q  PA+RVADLLQHI QMK  +GYGFK
Sbjct: 826  GDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFK 885

Query: 891  EEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDG 950
            +EYE+  EG    WD  K+ +    +R   + +YD  RV+L  + GDP++DYINANYIDG
Sbjct: 886  QEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDG 941

Query: 951  YHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGD 1010
            YHR  H+IATQGP  E V DFWRM+WQE+ +SIVM+T LVEVGRVKC RYWP+D++ YGD
Sbjct: 942  YHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGD 1001

Query: 1011 IKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVK 1070
            IK+ L++TE LAEYV+RTF ++++GY    E+R FHFT+WP+HGVP +ATGLL F+R+VK
Sbjct: 1002 IKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVK 1061

Query: 1071 FLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTE 1130
               PP+AGPIV+HCSAG GRTGC+I +D MLDMAE EGVVDI+NCV+ L ++RVN++QTE
Sbjct: 1062 ASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTE 1121

Query: 1131 EQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVR 1190
            EQY+F+HDAILEACLCG T IPV EF++ Y  + R+DPQ+NSSQ+++EFQTLN VTP + 
Sbjct: 1122 EQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLD 1181

Query: 1191 PEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQ 1250
             E+CSI LLPRN DKNRSMDVLP DRCLPFLIS DG+S+NYINAAL DS+ + AAF+VT 
Sbjct: 1182 VEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTL 1241

Query: 1251 HPLPNTVADFWRLVFDYNCSSVVMLNEM---DTAQFCMQYWPEKTSGCYGPIQVEFVSAD 1307
            HPL +T  DFWRLV+DY C+S+VMLN++   ++A  C+QYWPE     YG ++VEF+S  
Sbjct: 1242 HPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGT 1301

Query: 1308 IDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQY 1367
             DED++ R+FR+ N++R Q+G+ +V+H Q++ W AYRDTP SK++ L ++  ++KWQ   
Sbjct: 1302 ADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQA-- 1359

Query: 1368 DGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQY 1427
            +  +GRT+VHCLNGGGRSGTFCA  +V EMI+  N++DVF   KTLRN K NMVET++QY
Sbjct: 1360 ESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQY 1419

Query: 1428 KFVYEVALEYL 1438
             F Y+VALEYL
Sbjct: 1420 HFCYDVALEYL 1430


>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
            precursor [Homo sapiens]
          Length = 1442

 Score = 1540 bits (3988), Expect = 0.0
 Identities = 752/1457 (51%), Positives = 1011/1457 (69%), Gaps = 40/1457 (2%)

Query: 1    MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSN---CGYSVALGTNGFTWEQI 57
            MA   AL L+L  +L  P       ++ A GC+F+E       C YS A   + F WEQ+
Sbjct: 1    MARAQALVLALTFQLCAP-----ETETPAAGCTFEEASDPAVPCEYSQAQ-YDDFQWEQV 54

Query: 58   NTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSP 117
                       +P GS++MVN+S  A GQ+AH++  +L ENDTHC+ F Y+  SRD  SP
Sbjct: 55   RIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSP 114

Query: 118  GALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYI 177
            G L VYV+VNGGP G+ VWN++G     W +AELA+STFWP+ YQV+FE++      GY+
Sbjct: 115  GTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYM 174

Query: 178  AVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTAL 237
             +D++ +L++PC KAPHF RL +VEVN GQNA+FQC+A G+ ++ ++  LQ+ +G     
Sbjct: 175  GLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPA 234

Query: 238  MVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPEL 297
               R ++HRRF AT  +A  ++     YRCV ++  G+GVSN+AELIVKEPPTPIAPP+L
Sbjct: 235  AGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQL 294

Query: 298  LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357
            L  G TYL I+ N NSIIGDGPI+ KE+EYR   G WAE H V    YKLWHLDPD EYE
Sbjct: 295  LRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYE 354

Query: 358  IRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRC 417
            I VLLTRPG+GGTG PGPPL +RTKCA+P+  P+ +   +I+ARQLTLQWEP GY VTRC
Sbjct: 355  ISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRC 414

Query: 418  HSYNLTVQYQYVF----NQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMES 473
            H+Y +++ Y Y      NQ   E  +  Q  S YT++ L P+  + +RL+L+NPEGR E 
Sbjct: 415  HTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEG 474

Query: 474  EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSA 533
            +E+  QT+EDVP  +  ES+   P E+ I+++W+ P E NG+IT YEI+Y+++ S DP+ 
Sbjct: 475  KEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAV 534

Query: 534  DLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPE 593
            ++   R  + KLRNET+H+F  L+PGTTY F+++A T KGFG    T I T ISAPS   
Sbjct: 535  NVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDY 594

Query: 594  YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
             D  +PL E++ TITV+L+PAQ RGAP+SVYQ++V+EER ++ RR     +CF VP+++ 
Sbjct: 595  ADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFE 654

Query: 654  NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713
             A +   +HYF AEL  ++LP   PFTVGDN+TY G+WNPPL P K+Y IYFQA S   G
Sbjct: 655  AALARGLVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKG 714

Query: 714  ETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRN 773
            ET++NC+R+A K A  ++   +E  ++ +    + G+ AG L  +I+LLG ++ I R+  
Sbjct: 715  ETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKG- 773

Query: 774  AYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFT-- 831
                    K     K T +  Q +   +++ D+  T  S  + DE    S  D +G++  
Sbjct: 774  --------KPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTR 825

Query: 832  -DGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFK 890
             D   G +++ +  +   P R C      Y   Q  PA+RVADLLQHI QMK  +GYGFK
Sbjct: 826  GDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFK 885

Query: 891  EEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYID- 949
            +EYE+  EG    WD  K+ +    +R   + +YD  RV+L  + GDP++DYINANYID 
Sbjct: 886  QEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDI 941

Query: 950  -----GYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD 1004
                 GYHR  H+IATQGP  E V DFWRM+WQE+ +SIVM+T LVEVGRVKC RYWP+D
Sbjct: 942  RINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPED 1001

Query: 1005 TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLG 1064
            ++ YGDIK+ L++TE LAEYV+RTF ++++GY    E+R FHFT+WP+HGVP +ATGLL 
Sbjct: 1002 SDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLA 1061

Query: 1065 FVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRV 1124
            F+R+VK   PP+AGPIV+HCSAG GRTGC+I +D MLDMAE EGVVDI+NCV+ L ++RV
Sbjct: 1062 FIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRV 1121

Query: 1125 NLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNI 1184
            N++QTEEQY+F+HDAILEACLCG T IPV EF++ Y  + R+DPQ+NSSQ+++EFQTLN 
Sbjct: 1122 NMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNS 1181

Query: 1185 VTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPA 1244
            VTP +  E+CSI LLPRN DKNRSMDVLP DRCLPFLIS DG+S+NYINAAL DS+ + A
Sbjct: 1182 VTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSA 1241

Query: 1245 AFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM---DTAQFCMQYWPEKTSGCYGPIQV 1301
            AF+VT HPL +T  DFWRLV+DY C+S+VMLN++   ++A  C+QYWPE     YG ++V
Sbjct: 1242 AFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEV 1301

Query: 1302 EFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLE 1361
            EF+S   DED++ R+FR+ N++R Q+G+ +V+H Q++ W AYRDTP SK++ L ++  ++
Sbjct: 1302 EFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVD 1361

Query: 1362 KWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMV 1421
            KWQ   +  +GRT+VHCLNGGGRSGTFCA  +V EMI+  N++DVF   KTLRN K NMV
Sbjct: 1362 KWQA--ESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMV 1419

Query: 1422 ETLEQYKFVYEVALEYL 1438
            ET++QY F Y+VALEYL
Sbjct: 1420 ETMDQYHFCYDVALEYL 1436


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
            precursor [Homo sapiens]
          Length = 1502

 Score =  510 bits (1313), Expect = e-144
 Identities = 379/1234 (30%), Positives = 581/1234 (47%), Gaps = 157/1234 (12%)

Query: 253  SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306
            SVA  +  S  ++R V  ++ G G  +   L       P + P       L +      W
Sbjct: 376  SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 435

Query: 307  IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366
             +P   +    G  +   ++       W + ++ DS    + +L P   Y ++VL     
Sbjct: 436  KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 493

Query: 367  EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
              G GP    +   T+   P   P N +        + L W P           +    Y
Sbjct: 494  SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 544

Query: 427  QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDV 484
            + V+   ++  E+   I+  + Y L+GL+P      RL   +P+G   S   +       
Sbjct: 545  ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI------- 597

Query: 485  PGAVPLESIQGGPFEEK------IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADL 535
              A  ++S+    F  K      + + W+ P   N  +  ++I Y   K V  +D  A  
Sbjct: 598  -SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA-- 653

Query: 536  SSQRGKVFKLRNETHHLFVGLYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPE 593
                         T  L V L P  +YSF +  + ++A G    VT + A  +   + P 
Sbjct: 654  -------------TQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPA 699

Query: 594  YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
            +   T L   D  ITV L    +       Y ++V    L+KSR        F  P    
Sbjct: 700  FIGKTNL---DGMITVQLPEVPANENIKGYYIIIVP---LKKSRGK------FIKPWESP 747

Query: 654  NASSLDSL------------HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSP 697
            +   LD L            +    ELKP   A+  V    FT+GD+K Y G+ N  L  
Sbjct: 748  DEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQS 807

Query: 698  LKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMF 757
             + Y ++F      + E+K+      +    + + +      + +  + + G +  ++  
Sbjct: 808  GQEY-VFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFI 866

Query: 758  IIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRND 817
            I I++ ++L            Y  K  +K+ E+ S                 K S   N 
Sbjct: 867  ICIVIAILL------------YKSKPDRKRAESDS----------------RKSSIPNNK 898

Query: 818  EGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRVA 872
            E                          I +H     DPVE+       P     P I + 
Sbjct: 899  E--------------------------IPSH--HPTDPVELRRLNFQTPGMASHPPIPIL 930

Query: 873  DLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLL 932
            +L  HI ++K      F +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L 
Sbjct: 931  ELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLS 990

Query: 933  VLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEV 992
             ++G P SDY+NANYIDGY +   YIATQG + ET  DFWRMIW++ SA++VM+T L E 
Sbjct: 991  AIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEER 1050

Query: 993  GRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWP 1051
             RVKC +YWP   TE +G ++VTL++T  LA Y +RTF + K G  E RE+R F FT+WP
Sbjct: 1051 SRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWP 1110

Query: 1052 DHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVD 1111
            DHGVP + T  L F+R+VK  NPP+AGP+VVHCSAG GRTGCFI ID ML+  ++E  VD
Sbjct: 1111 DHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVD 1170

Query: 1112 IFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP-QT 1170
            I+  V  +RAQR  +VQTE+QY+F+HDA+LEA  CGNT +P    R+LY  I +L   +T
Sbjct: 1171 IYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA---RNLYAYIQKLTQIET 1227

Query: 1171 NSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESS 1229
              +    E +   + + +          LP N  KNR ++++P +     L  + G E S
Sbjct: 1228 GENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS 1287

Query: 1230 NYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQY 1287
            +YINA+ +D ++Q  A++ TQ PL  T  DFWR+++++N + VVML ++     + C QY
Sbjct: 1288 DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQY 1347

Query: 1288 WPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTP 1347
            WP + S  Y    V+ ++       I R F++ +    Q   R V+  Q+  WP  +  P
Sbjct: 1348 WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVP 1404

Query: 1348 PSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVF 1407
             S    +  + ++ K +EQ+ G++G   VHC  G GR+G F  +  V E ++ + ++D+F
Sbjct: 1405 KSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF 1463

Query: 1408 HIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1441
              VK LR  +  MV+T +QY+F Y  ALEYL SF
Sbjct: 1464 QTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1497



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 82/325 (25%), Positives = 133/325 (40%), Gaps = 34/325 (10%)

Query: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316
           R  + Y CV  S  G  +   A++ VK  P P   P   E  A   T  W   N   +  
Sbjct: 292 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 348

Query: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
                + + + + +   + E   V +  Y +  L P  +YE RV+       G GPP  P
Sbjct: 349 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 404

Query: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432
           + T+T    P   P++V+   + +  + +QW    EP G  +     Y      Q+V N 
Sbjct: 405 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 463

Query: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490
            ++     +  S   T+  L P  T  +++L   S  +G + S+  V+ T+  VPG  PL
Sbjct: 464 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 517

Query: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550
                   E  I + W PP   +  I  YE+ YK  G       ++ + G  ++L+    
Sbjct: 518 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 570

Query: 551 HLFVGLYPGTTYSFTIKASTAKGFG 575
               GL P + Y F + A + +G G
Sbjct: 571 ----GLKPNSLYYFRLAARSPQGLG 591


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
            precursor [Homo sapiens]
          Length = 1501

 Score =  510 bits (1313), Expect = e-144
 Identities = 383/1236 (30%), Positives = 582/1236 (47%), Gaps = 165/1236 (13%)

Query: 253  SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306
            SVA  +  S  ++R V  ++ G G  +   L       P + P       L +      W
Sbjct: 379  SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438

Query: 307  IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366
             +P   +    G  +   ++       W + ++ DS    + +L P   Y ++VL     
Sbjct: 439  KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 496

Query: 367  EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
              G GP    +   T+   P   P N +        + L W P           +    Y
Sbjct: 497  SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 547

Query: 427  QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDV 484
            + V+   ++  E+   I+  + Y L+GL+P      RL   +P+G   S   +       
Sbjct: 548  ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI------- 600

Query: 485  PGAVPLESIQGGPFEEK------IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADL 535
              A  ++S+    F  K      + + W+ P   N  +  ++I Y   K V  +D  A  
Sbjct: 601  -SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA-- 656

Query: 536  SSQRGKVFKLRNETHHLFVGLYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPE 593
                         T  L V L P  +YSF +  + ++A G    VT + A  +   + P 
Sbjct: 657  -------------TQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPA 702

Query: 594  YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
            +   T L   D  ITV L    +       Y ++V    L+KSR        F  P    
Sbjct: 703  FIGKTNL---DGMITVQLPEVPANENIKGYYIIIVP---LKKSRGK------FIKPWESP 750

Query: 654  NASSLDSL------------HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSP 697
            +   LD L            +    ELKP   A+  V    FT+GD+K Y G+ N  L  
Sbjct: 751  DEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQS 810

Query: 698  LKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLL-- 755
             + Y ++F      + E+K+      +  +    S  ++P+   D    +  V+  +L  
Sbjct: 811  GQEY-VFFVLAVMEHAESKMYAT---SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAV 866

Query: 756  MFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASR 815
            +FII ++  +L  KR+R                               A+  + K S   
Sbjct: 867  VFIICIVIAILLYKRKR-------------------------------AESDSRKSSIPN 895

Query: 816  NDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIR 870
            N E                          I +H     DPVE+       P     P I 
Sbjct: 896  NKE--------------------------IPSH--HPTDPVELRRLNFQTPGMASHPPIP 927

Query: 871  VADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVR 930
            + +L  HI ++K      F +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV 
Sbjct: 928  ILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVL 987

Query: 931  LLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLV 990
            L  ++G P SDY+NANYIDGY +   YIATQG + ET  DFWRMIW++ SA++VM+T L 
Sbjct: 988  LSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLE 1047

Query: 991  EVGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTS 1049
            E  RVKC +YWP   TE +G ++VTL++T  LA Y +RTF + K G  E RE+R F FT+
Sbjct: 1048 ERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTA 1107

Query: 1050 WPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGV 1109
            WPDHGVP + T  L F+R+VK  NPP+AGP+VVHCSAG GRTGCFI ID ML+  ++E  
Sbjct: 1108 WPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKT 1167

Query: 1110 VDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP- 1168
            VDI+  V  +RAQR  +VQTE+QY+F+HDA+LEA  CGNT +P    R+LY  I +L   
Sbjct: 1168 VDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA---RNLYAYIQKLTQI 1224

Query: 1169 QTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-E 1227
            +T  +    E +   + + +          LP N  KNR ++++P +     L  + G E
Sbjct: 1225 ETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVE 1284

Query: 1228 SSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCM 1285
             S+YINA+ +D ++Q  A++ TQ PL  T  DFWR+++++N + VVML ++     + C 
Sbjct: 1285 GSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCH 1344

Query: 1286 QYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRD 1345
            QYWP + S  Y    V+ ++       I R F++ +    Q   R V+  Q+  WP  + 
Sbjct: 1345 QYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QG 1401

Query: 1346 TPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIID 1405
             P S    +  + ++ K +EQ+ G++G   VHC  G GR+G F  +  V E ++ + ++D
Sbjct: 1402 VPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVD 1460

Query: 1406 VFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1441
            +F  VK LR  +  MV+T +QY+F Y  ALEYL SF
Sbjct: 1461 IFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1496



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 82/325 (25%), Positives = 133/325 (40%), Gaps = 34/325 (10%)

Query: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316
           R  + Y CV  S  G  +   A++ VK  P P   P   E  A   T  W   N   +  
Sbjct: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 351

Query: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
                + + + + +   + E   V +  Y +  L P  +YE RV+       G GPP  P
Sbjct: 352 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 407

Query: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432
           + T+T    P   P++V+   + +  + +QW    EP G  +     Y      Q+V N 
Sbjct: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 466

Query: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490
            ++     +  S   T+  L P  T  +++L   S  +G + S+  V+ T+  VPG  PL
Sbjct: 467 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 520

Query: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550
                   E  I + W PP   +  I  YE+ YK  G       ++ + G  ++L+    
Sbjct: 521 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 573

Query: 551 HLFVGLYPGTTYSFTIKASTAKGFG 575
               GL P + Y F + A + +G G
Sbjct: 574 ----GLKPNSLYYFRLAARSPQGLG 594


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score =  510 bits (1313), Expect = e-144
 Identities = 351/1090 (32%), Positives = 542/1090 (49%), Gaps = 144/1090 (13%)

Query: 390  PQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTL 449
            PQN+ +  +      L W+P   A       + TV ++ + +QQ+ +    I T + +TL
Sbjct: 919  PQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQN---ITTDTRFTL 975

Query: 450  RGLRPFMT--IRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPF------EEK 501
             GL+P  T  I++R   S   G +      +Q+       +P+E +    F      +  
Sbjct: 976  TGLKPDTTYDIKVRAWTSKGSGPLSPS---IQSR-----TMPVEQVFAKNFRVAAAMKTS 1027

Query: 502  IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561
            + + W+ P+     +  ++I Y          D  S R            L   L P T 
Sbjct: 1028 VLLSWEVPDSYKSAVP-FKILYNGQSV---EVDGHSMR-----------KLIADLQPNTE 1072

Query: 562  YSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGA 619
            YSF +  + S+A G    V+ R A  +    +P           D    + +   Q    
Sbjct: 1073 YSFVLMNRGSSAGGLQHLVSIRTAPDL----LPHKPLPASAYIEDGRFDLSMPHVQDPSL 1128

Query: 620  PVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAE----------LK 669
                Y +VV  +R+  S     +   +S P        L+++     E          LK
Sbjct: 1129 VRWFYIVVVPIDRVGGSM----LTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLK 1184

Query: 670  P---ANLPVT-QPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATK 725
            P   A L V  + FT+GD K Y G++N PLSP  SY  +  A  K   + K    R A+ 
Sbjct: 1185 PYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RYASS 1240

Query: 726  GASTQNSNTVEPEKQVDNTVKM--AGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKL 783
              S +    V P +Q +    +   G +  +++ I+I++ ++L                 
Sbjct: 1241 PYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLF---------------- 1284

Query: 784  AKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTL 843
              K+K T S + ++   +   D                                      
Sbjct: 1285 --KRKRTHSPSSKDEQSIGLKD-------------------------------------- 1304

Query: 844  TIQTHPYRTCDPVEM-----SYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPE 898
            ++  H   + DPVEM       P  +  P I + DL  +I ++K   G  F +EYE++  
Sbjct: 1305 SLLAH---SSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDP 1361

Query: 899  GQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYI 958
            GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  +DG P SDYINANYIDGY +   YI
Sbjct: 1362 GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYI 1421

Query: 959  ATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIE 1017
            ATQGP+ ET+ DFWRM+W++ +A++VM+T L E  RVKC +YWP   TE  G I+VTL++
Sbjct: 1422 ATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLD 1481

Query: 1018 TEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEA 1077
            T  LA Y +RTF + K G  E RELR F F +WPDHGVP Y T +L F+R+VK  NP +A
Sbjct: 1482 TVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDA 1541

Query: 1078 GPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVH 1137
            GP+VVHCSAG GRTGCFI ID ML+  ++E  VDI+  V  +R+QR  +VQTE+QYVF+H
Sbjct: 1542 GPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIH 1601

Query: 1138 DAILEACLCGNTAIPVCEFRSLYYNISRL---DPQTNSSQIKDEFQTLNIVTPRVRPEDC 1194
            +A+LEA  CG+T +P    R+LY +I +L    P  + + ++ EF+ L   + +      
Sbjct: 1602 EALLEAATCGHTEVPA---RNLYAHIQKLGQVPPGESVTAMELEFKLL--ASSKAHTSRF 1656

Query: 1195 SIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPL 1253
                LP N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++ TQ PL
Sbjct: 1657 ISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPL 1716

Query: 1254 PNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDED 1311
              +  DFWR+++++N + +VML ++     + C QYWP + S  Y    V+ ++      
Sbjct: 1717 AESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQ 1776

Query: 1312 IIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGRE 1371
             I R F++ +    Q   R ++  Q+  WP  +  P +    +  + ++ K +EQ+ G++
Sbjct: 1777 YILREFKVTDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFIDFIGQVHKTKEQF-GQD 1832

Query: 1372 GRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVY 1431
            G   VHC  G GR+G F  +  V E ++ + ++D+F  VKTLR  +  MV+T +QY+  Y
Sbjct: 1833 GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY 1892

Query: 1432 EVALEYLSSF 1441
              ALEYL SF
Sbjct: 1893 RAALEYLGSF 1902



 Score = 80.9 bits (198), Expect = 8e-15
 Identities = 100/413 (24%), Positives = 161/413 (38%), Gaps = 40/413 (9%)

Query: 249 SATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE---LLAVGATYL 305
           +++ ++ D    ++ +++   RSD G GV            TP APP+    +++G+T +
Sbjct: 564 TSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTV 623

Query: 306 ---WIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVD--SPNYKLWHLDPDVEY-EIR 359
              W+ P A+S   +G I    V Y    G     H+VD  S  +  W L    ++ E R
Sbjct: 624 RVSWVPPPADS--RNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYR 681

Query: 360 VLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----------EP 409
           V +    + G GP   P+  RT    P   P+ VE+  + +  + + W          + 
Sbjct: 682 VWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQI 741

Query: 410 FGYAVTRCHSYN-----LTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLL 464
            GY VT     N     L +    +  + Q+  EE        T+ GL P  T  + +  
Sbjct: 742 RGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEE--SEDYETTISGLTPETTYSVTVAA 799

Query: 465 SNPEG-RMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINY 523
              +G    S+  +V T   VPG  P   I        + +QW PP E  G +  Y + Y
Sbjct: 800 YTTKGDGARSKPKIVTTTGAVPGR-PTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQY 857

Query: 524 KAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIA 583
                  P+   +   GK     ++ H    GL+ GTTY F + A    G G      I 
Sbjct: 858 CRADEARPN---TIDFGK-----DDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIR 909

Query: 584 TKISAPS-MPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQK 635
           T    PS  P+    T L  + T +         R   +  Y +V ++   Q+
Sbjct: 910 TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQ 962



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 106/454 (23%), Positives = 173/454 (38%), Gaps = 82/454 (18%)

Query: 203 VNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSV 262
           V   + AT  C AGG     +  W + +   D A    R+   R  S  + +  + +   
Sbjct: 146 VEKARTATMLCAAGGN-PDPEISWFKDFLPVDPATSNGRIKQLR--SGALQIESSEESDQ 202

Query: 263 SKYRCVIRSDGGSGVSNYAELIVKE---PPTPIAPPE-------------LLAVGATYLW 306
            KY CV  +  G+  S  A L V+     P    PP               +AVGA   +
Sbjct: 203 GKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPY 262

Query: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNY------KLWHLDPDVEYEIRV 360
           +K    +       + KE E          +++V S NY       L  ++   +  ++ 
Sbjct: 263 VKWMMGA-----EELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKA 317

Query: 361 LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY 420
           L           P PP+              ++ + +  A  +TL W+         +  
Sbjct: 318 L-----------PKPPI--------------DLVVTETTATSVTLTWDSGNSEPVTYYG- 351

Query: 421 NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELV-VQ 479
              +QY+    +  ++  + + T+  Y++ GL PF     R+L  N  GR    E V  +
Sbjct: 352 ---IQYRAAGTEGPFQEVDGVATT-RYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRAR 407

Query: 480 TEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQR 539
           T E  P + P            + +QW+PP E NG++  Y + Y       P+A      
Sbjct: 408 TGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNA------ 461

Query: 540 GKVFKLRNETHHLFV---GLYPGTTYSFTIKASTAKGFGPP-VTTRIATKISAPSMP-EY 594
              +   N    L      L PG TYS  + A TA G GPP  T ++ T+   P+ P ++
Sbjct: 462 ---WHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADF 518

Query: 595 DTDTPLNETDTTITV-MLKPAQSRGAPVSVYQLV 627
             +    E+DT I +  L P Q R   + +Y+LV
Sbjct: 519 QAEV---ESDTRIQLSWLLPPQER---IIMYELV 546



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 96/377 (25%), Positives = 147/377 (38%), Gaps = 39/377 (10%)

Query: 263 SKYRCVIRSDGGSGVSNYAELIVK---EPPTPIAPPELLAVGATYLWIKPNANSIIGDGP 319
           + Y CV  S  G  +   A++ VK   +PP  +   E  A   T  W   N+       P
Sbjct: 294 ANYTCVAISSLGM-IEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSE------P 346

Query: 320 IILKEVEYRT--TTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPL 377
           +    ++YR   T G + E   V +  Y +  L P  EY  RVL       G GPP   +
Sbjct: 347 VTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN--SIGRGPPSEAV 404

Query: 378 TTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEA 437
             RT    P   P+ V+   + A  + +QWEP          Y +   Y    +++   A
Sbjct: 405 RARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV---YYTPDSRRPPNA 461

Query: 438 EEVIQTSSHY--TLRGLRPFMTIRLRLLLSNPEG-RMESEELVVQTEEDVPGAVPLESIQ 494
                T +    T+  L P +T  LR+L     G    S  + V+T++ VP A P +   
Sbjct: 462 WHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQPADFQA 520

Query: 495 GGPFEEKIYIQW-KPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLF 553
               + +I + W  PP E    I +YE+ Y A    D    ++      + L +      
Sbjct: 521 EVESDTRIQLSWLLPPQER---IIMYELVYWAAEDEDQQHKVTFDPTSSYTLED------ 571

Query: 554 VGLYPGTTYSFTIKASTAKGFG---PPVTTRIATKISAPSMPEYDT-DTPLNETDTTITV 609
             L P T Y F + A +  G G   P +  R A   S PS P        +  T   ++ 
Sbjct: 572 --LKPDTLYRFQLAARSDMGVGVFTPTIEARTAQ--STPSAPPQKVMCVSMGSTTVRVSW 627

Query: 610 MLKPAQSRGAPVSVYQL 626
           +  PA SR   ++ Y +
Sbjct: 628 VPPPADSRNGVITQYSV 644



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 74/296 (25%), Positives = 113/296 (38%), Gaps = 52/296 (17%)

Query: 308  KPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLL-TRPG 366
            +P    II D  ++L E ++R       ET I          L P+  Y + V   T  G
Sbjct: 755  EPRGLPIIQD--VMLAEAQWRPEESEDYETTISG--------LTPETTYSVTVAAYTTKG 804

Query: 367  EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEP--------FGYAVTRCH 418
            +G    P    TT       V G   + I         LQW P         GY +  C 
Sbjct: 805  DGARSKPKIVTTTGA-----VPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCR 859

Query: 419  SYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVV 478
            +           ++ +    +  +   H+T+ GL    T   RL   N  G  E  E  +
Sbjct: 860  A-----------DEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEI 908

Query: 479  QTEEDVPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLDPSADLS 536
            +T ED+P   P      G       + W PP   E NG I  Y + ++         D++
Sbjct: 909  RTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR---------DIN 959

Query: 537  SQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMP 592
            SQ+ ++  +  +T     GL P TTY   ++A T+KG GP     ++  I + +MP
Sbjct: 960  SQQ-ELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGP-----LSPSIQSRTMP 1009


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score =  510 bits (1313), Expect = e-144
 Identities = 351/1090 (32%), Positives = 542/1090 (49%), Gaps = 144/1090 (13%)

Query: 390  PQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTL 449
            PQN+ +  +      L W+P   A       + TV ++ + +QQ+ +    I T + +TL
Sbjct: 910  PQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQN---ITTDTRFTL 966

Query: 450  RGLRPFMT--IRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPF------EEK 501
             GL+P  T  I++R   S   G +      +Q+       +P+E +    F      +  
Sbjct: 967  TGLKPDTTYDIKVRAWTSKGSGPLSPS---IQSR-----TMPVEQVFAKNFRVAAAMKTS 1018

Query: 502  IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561
            + + W+ P+     +  ++I Y          D  S R            L   L P T 
Sbjct: 1019 VLLSWEVPDSYKSAVP-FKILYNGQSV---EVDGHSMR-----------KLIADLQPNTE 1063

Query: 562  YSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGA 619
            YSF +  + S+A G    V+ R A  +    +P           D    + +   Q    
Sbjct: 1064 YSFVLMNRGSSAGGLQHLVSIRTAPDL----LPHKPLPASAYIEDGRFDLSMPHVQDPSL 1119

Query: 620  PVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAE----------LK 669
                Y +VV  +R+  S     +   +S P        L+++     E          LK
Sbjct: 1120 VRWFYIVVVPIDRVGGSM----LTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLK 1175

Query: 670  P---ANLPVT-QPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATK 725
            P   A L V  + FT+GD K Y G++N PLSP  SY  +  A  K   + K    R A+ 
Sbjct: 1176 PYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RYASS 1231

Query: 726  GASTQNSNTVEPEKQVDNTVKM--AGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKL 783
              S +    V P +Q +    +   G +  +++ I+I++ ++L                 
Sbjct: 1232 PYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLF---------------- 1275

Query: 784  AKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTL 843
              K+K T S + ++   +   D                                      
Sbjct: 1276 --KRKRTHSPSSKDEQSIGLKD-------------------------------------- 1295

Query: 844  TIQTHPYRTCDPVEM-----SYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPE 898
            ++  H   + DPVEM       P  +  P I + DL  +I ++K   G  F +EYE++  
Sbjct: 1296 SLLAH---SSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDP 1352

Query: 899  GQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYI 958
            GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  +DG P SDYINANYIDGY +   YI
Sbjct: 1353 GQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYI 1412

Query: 959  ATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIE 1017
            ATQGP+ ET+ DFWRM+W++ +A++VM+T L E  RVKC +YWP   TE  G I+VTL++
Sbjct: 1413 ATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLD 1472

Query: 1018 TEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEA 1077
            T  LA Y +RTF + K G  E RELR F F +WPDHGVP Y T +L F+R+VK  NP +A
Sbjct: 1473 TVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDA 1532

Query: 1078 GPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVH 1137
            GP+VVHCSAG GRTGCFI ID ML+  ++E  VDI+  V  +R+QR  +VQTE+QYVF+H
Sbjct: 1533 GPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIH 1592

Query: 1138 DAILEACLCGNTAIPVCEFRSLYYNISRL---DPQTNSSQIKDEFQTLNIVTPRVRPEDC 1194
            +A+LEA  CG+T +P    R+LY +I +L    P  + + ++ EF+ L   + +      
Sbjct: 1593 EALLEAATCGHTEVPA---RNLYAHIQKLGQVPPGESVTAMELEFKLL--ASSKAHTSRF 1647

Query: 1195 SIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPL 1253
                LP N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++ TQ PL
Sbjct: 1648 ISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPL 1707

Query: 1254 PNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDED 1311
              +  DFWR+++++N + +VML ++     + C QYWP + S  Y    V+ ++      
Sbjct: 1708 AESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQ 1767

Query: 1312 IIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGRE 1371
             I R F++ +    Q   R ++  Q+  WP  +  P +    +  + ++ K +EQ+ G++
Sbjct: 1768 YILREFKVTDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFIDFIGQVHKTKEQF-GQD 1823

Query: 1372 GRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVY 1431
            G   VHC  G GR+G F  +  V E ++ + ++D+F  VKTLR  +  MV+T +QY+  Y
Sbjct: 1824 GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCY 1883

Query: 1432 EVALEYLSSF 1441
              ALEYL SF
Sbjct: 1884 RAALEYLGSF 1893



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 106/454 (23%), Positives = 173/454 (38%), Gaps = 82/454 (18%)

Query: 203 VNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSV 262
           V   + AT  C AGG     +  W + +   D A    R+   R  S  + +  + +   
Sbjct: 146 VEKARTATMLCAAGGN-PDPEISWFKDFLPVDPATSNGRIKQLR--SGALQIESSEESDQ 202

Query: 263 SKYRCVIRSDGGSGVSNYAELIVKE---PPTPIAPPE-------------LLAVGATYLW 306
            KY CV  +  G+  S  A L V+     P    PP               +AVGA   +
Sbjct: 203 GKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPY 262

Query: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNY------KLWHLDPDVEYEIRV 360
           +K    +       + KE E          +++V S NY       L  ++   +  ++ 
Sbjct: 263 VKWMMGA-----EELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKA 317

Query: 361 LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY 420
           L           P PP+              ++ + +  A  +TL W+         +  
Sbjct: 318 L-----------PKPPI--------------DLVVTETTATSVTLTWDSGNSEPVTYYG- 351

Query: 421 NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELV-VQ 479
              +QY+    +  ++  + + T+  Y++ GL PF     R+L  N  GR    E V  +
Sbjct: 352 ---IQYRAAGTEGPFQEVDGVATT-RYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRAR 407

Query: 480 TEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQR 539
           T E  P + P            + +QW+PP E NG++  Y + Y       P+A      
Sbjct: 408 TGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNA------ 461

Query: 540 GKVFKLRNETHHLFV---GLYPGTTYSFTIKASTAKGFGPP-VTTRIATKISAPSMP-EY 594
              +   N    L      L PG TYS  + A TA G GPP  T ++ T+   P+ P ++
Sbjct: 462 ---WHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADF 518

Query: 595 DTDTPLNETDTTITV-MLKPAQSRGAPVSVYQLV 627
             +    E+DT I +  L P Q R   + +Y+LV
Sbjct: 519 QAEV---ESDTRIQLSWLLPPQER---IIMYELV 546



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 96/377 (25%), Positives = 147/377 (38%), Gaps = 39/377 (10%)

Query: 263 SKYRCVIRSDGGSGVSNYAELIVK---EPPTPIAPPELLAVGATYLWIKPNANSIIGDGP 319
           + Y CV  S  G  +   A++ VK   +PP  +   E  A   T  W   N+       P
Sbjct: 294 ANYTCVAISSLGM-IEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSE------P 346

Query: 320 IILKEVEYRT--TTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPL 377
           +    ++YR   T G + E   V +  Y +  L P  EY  RVL       G GPP   +
Sbjct: 347 VTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN--SIGRGPPSEAV 404

Query: 378 TTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEA 437
             RT    P   P+ V+   + A  + +QWEP          Y +   Y    +++   A
Sbjct: 405 RARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV---YYTPDSRRPPNA 461

Query: 438 EEVIQTSSHY--TLRGLRPFMTIRLRLLLSNPEG-RMESEELVVQTEEDVPGAVPLESIQ 494
                T +    T+  L P +T  LR+L     G    S  + V+T++ VP A P +   
Sbjct: 462 WHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQPADFQA 520

Query: 495 GGPFEEKIYIQW-KPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLF 553
               + +I + W  PP E    I +YE+ Y A    D    ++      + L +      
Sbjct: 521 EVESDTRIQLSWLLPPQER---IIMYELVYWAAEDEDQQHKVTFDPTSSYTLED------ 571

Query: 554 VGLYPGTTYSFTIKASTAKGFG---PPVTTRIATKISAPSMPEYDT-DTPLNETDTTITV 609
             L P T Y F + A +  G G   P +  R A   S PS P        +  T   ++ 
Sbjct: 572 --LKPDTLYRFQLAARSDMGVGVFTPTIEARTAQ--STPSAPPQKVMCVSMGSTTVRVSW 627

Query: 610 MLKPAQSRGAPVSVYQL 626
           +  PA SR   ++ Y +
Sbjct: 628 VPPPADSRNGVITQYSV 644



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 64/254 (25%), Positives = 98/254 (38%), Gaps = 42/254 (16%)

Query: 350  LDPDVEYEIRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWE 408
            L P+  Y + V   T  G+G    P    TT       V G   + I         LQW 
Sbjct: 778  LTPETTYSVTVAAYTTKGDGARSKPKIVTTTGA-----VPGRPTMMISTTAMNTALLQWH 832

Query: 409  P--------FGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRL 460
            P         GY +  C +           ++ +    +  +   H+T+ GL    T   
Sbjct: 833  PPKELPGELLGYRLQYCRA-----------DEARPNTIDFGKDDQHFTVTGLHKGTTYIF 881

Query: 461  RLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITL 518
            RL   N  G  E  E  ++T ED+P   P      G       + W PP   E NG I  
Sbjct: 882  RLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIIS 941

Query: 519  YEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPV 578
            Y + ++         D++SQ+ ++  +  +T     GL P TTY   ++A T+KG GP  
Sbjct: 942  YTVVFR---------DINSQQ-ELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGP-- 989

Query: 579  TTRIATKISAPSMP 592
               ++  I + +MP
Sbjct: 990  ---LSPSIQSRTMP 1000



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 72/282 (25%), Positives = 118/282 (41%), Gaps = 15/282 (5%)

Query: 320 IILKEVEYRTTTGTWAETHIVDSP--NYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPL 377
           II+ E+ Y        +  +   P  +Y L  L PD  Y  R  L    + G G   P +
Sbjct: 540 IIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLY--RFQLAARSDMGVGVFTPTI 597

Query: 378 TTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQ--Y 435
             RT  + P   PQ V  V + +  + + W P             +V Y+ V  + +  +
Sbjct: 598 EARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRH 657

Query: 436 EAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGR-MESEELVVQTEEDVPGAVPLESIQ 494
             + + +  S + L GL  +   R+ +      G   ES  ++V+T+EDVP   P   ++
Sbjct: 658 VVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPP-RKVE 716

Query: 495 GGPFEEK-IYIQWK--PPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHH 551
             P     +++ WK   P++ +G I  Y++ Y  + + +P      Q   + + +  T  
Sbjct: 717 VEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETT-- 774

Query: 552 LFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISA-PSMP 592
              GL P TTYS T+ A T KG G     +I T   A P  P
Sbjct: 775 -ISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRP 815



 Score = 36.2 bits (82), Expect = 0.23
 Identities = 30/122 (24%), Positives = 48/122 (39%), Gaps = 10/122 (8%)

Query: 317  DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
            +G II   V +R         +I     + L  L PD  Y+I+V        G+GP  P 
Sbjct: 936  NGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWT--SKGSGPLSPS 993

Query: 377  LTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYE 436
            + +RT   + V   +N  +       + L WE          SY   V ++ ++N Q  E
Sbjct: 994  IQSRTMPVEQVFA-KNFRVAAAMKTSVLLSWEV-------PDSYKSAVPFKILYNGQSVE 1045

Query: 437  AE 438
             +
Sbjct: 1046 VD 1047


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score =  506 bits (1304), Expect = e-143
 Identities = 372/1208 (30%), Positives = 571/1208 (47%), Gaps = 155/1208 (12%)

Query: 275  SGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTW 334
            S V+   E      P  +    L A      W +P   + +  G  +   +E     G W
Sbjct: 407  SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNW 466

Query: 335  AETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVE 394
             + ++ DS    +  L  D  Y +RVL       G GP   P+  +T+   P   P N+ 
Sbjct: 467  QKHNVDDSLLTTVGSLLEDETYTVRVLAFT--SVGDGPLSDPIQVKTQQGVPGQ-PMNLR 523

Query: 395  IVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQY--EAEEVIQTSSHYTLRGL 452
                    +TL W P              ++Y+ +F +  +  E       ++ Y +  L
Sbjct: 524  AEARSETSITLSWSP--------PRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDL 575

Query: 453  RPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEK------IYIQW 506
            +P      RL   +P+G      +V Q          L+SI    F+ K      + + W
Sbjct: 576  KPNTEYAFRLAARSPQGLGAFTPVVRQRT--------LQSISPKNFKVKMIMKTSVLLSW 627

Query: 507  KPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTI 566
            + P+  N   T Y+I Y  + +LD                  T  L   L P T Y+F +
Sbjct: 628  EFPDNYNSP-TPYKIQYNGL-TLDVDG-------------RTTKKLITHLKPHTFYNFVL 672

Query: 567  --KASTAKGFGPPVTTRIATKI--SAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVS 622
              + S+  G    VT   A  +    PS+       P  + D  I V L   QS   PV 
Sbjct: 673  TNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQS---PVP 723

Query: 623  VYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANL------PVT 676
            V    +    L+KSR        F  P+       L+ L    + L+  +L       V 
Sbjct: 724  VQSYFIVMVPLRKSRGGQ-----FLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVP 778

Query: 677  QPFTV------------GDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLAT 724
            +P+              GD K Y G+ N  L P   Y ++  A+ + +  T       A+
Sbjct: 779  RPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFA-----AS 833

Query: 725  KGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLA 784
              +     +  +P+  VD    +  VI G ++ ++ ++ +++ I   +N        K  
Sbjct: 834  PFSDPFQLDNPDPQPIVDGEEGLIWVI-GPVLAVVFIICIVIAILLYKN--------KPD 884

Query: 785  KKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLT 844
             K+K+++               P TK   +  D                           
Sbjct: 885  SKRKDSE---------------PRTKCLLNNADLA------------------------- 904

Query: 845  IQTHPYRTCDPVEMSYPRDQFQ-------PAIRVADLLQHITQMKRGQGYGFKEEYEALP 897
                P+   DPVEM   R  FQ       P I +AD+ +H  ++K        +EYE++ 
Sbjct: 905  ----PHHPKDPVEMR--RINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 958

Query: 898  EGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHY 957
             GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  ++G   SDYINANY+DGY     Y
Sbjct: 959  PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1018

Query: 958  IATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLI 1016
            IATQGP+ ET  DFWRM+W++ SA+IVM+T L E  R+KC +YWP+  TE YG I+VTL+
Sbjct: 1019 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1078

Query: 1017 ETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPE 1076
            +T  LA + +RTF++ K G  E RE+R F FT+WPDHGVP Y T  L F+R+VK  NPP+
Sbjct: 1079 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1138

Query: 1077 AGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFV 1136
            AGPIVVHCSAG GRTGCFI ID ML+  + E  VD++  V  +R+QR  +VQTE+QY F+
Sbjct: 1139 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1198

Query: 1137 HDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSI 1196
            H+A+LEA  CGNT +P     +    +++++P  + + ++ EF+ L     +        
Sbjct: 1199 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFIS 1256

Query: 1197 GLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPN 1255
              LP N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++ TQ PL  
Sbjct: 1257 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1316

Query: 1256 TVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDII 1313
            T  DFWR++++ N + VVML ++     + C QYWP + S  Y    V+ ++       I
Sbjct: 1317 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1376

Query: 1314 HRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGR 1373
             R F++ +    Q   R V+  Q+  WP  +  P S    +  + ++ K +EQ+ G++G 
Sbjct: 1377 LREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF-GQDGP 1432

Query: 1374 TVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEV 1433
              VHC  G GR+G F  +  V E ++ + ++D+F  VK LR  +  MV+T ++Y+F Y+ 
Sbjct: 1433 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQA 1492

Query: 1434 ALEYLSSF 1441
            ALEYL SF
Sbjct: 1493 ALEYLGSF 1500



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 109/420 (25%), Positives = 174/420 (41%), Gaps = 49/420 (11%)

Query: 182 VRVLAHPCRKAPHFLRL-QNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT 240
           VR L    R AP F  L  + E+  G N    C+A G    + K W+Q   G +      
Sbjct: 225 VRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK-WMQ---GAEDLTPED 280

Query: 241 RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---EL 297
            +   R       V D+A      Y CV  S  G  +   A++ VK  P     P   E 
Sbjct: 281 DMPVGRNVLELTDVKDSAN-----YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTEN 334

Query: 298 LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTT--GTWAETHIVDSPNYKLWHLDPDVE 355
            A   T  W   N +      P+    +EY++ +  G +     + +  Y +  L P+ E
Sbjct: 335 TATSITITWDSGNPD------PVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSE 388

Query: 356 YEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFG 411
           YEI V  +     G GPP   + TRT    P   P+NV+   + A  + +QW    EP G
Sbjct: 389 YEIWV--SAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNG 446

Query: 412 YAVTRCHSYNLTVQYQY-VFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGR 470
             + R +    T++ ++ V N Q++  ++ + T+    L       T+R+    S  +G 
Sbjct: 447 --LIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLED--ETYTVRVLAFTSVGDGP 502

Query: 471 MESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLD 530
           + S+ + V+T++ VPG  P+        E  I + W PP + +  I  YE+ ++      
Sbjct: 503 L-SDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFR------ 552

Query: 531 PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFG---PPVTTRIATKIS 587
              D   + G+ F     T ++   L P T Y+F + A + +G G   P V  R    IS
Sbjct: 553 -EGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSIS 609


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
            isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score =  506 bits (1304), Expect = e-143
 Identities = 372/1208 (30%), Positives = 571/1208 (47%), Gaps = 155/1208 (12%)

Query: 275  SGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTW 334
            S V+   E      P  +    L A      W +P   + +  G  +   +E     G W
Sbjct: 403  SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNW 462

Query: 335  AETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVE 394
             + ++ DS    +  L  D  Y +RVL       G GP   P+  +T+   P   P N+ 
Sbjct: 463  QKHNVDDSLLTTVGSLLEDETYTVRVLAFT--SVGDGPLSDPIQVKTQQGVPGQ-PMNLR 519

Query: 395  IVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQY--EAEEVIQTSSHYTLRGL 452
                    +TL W P              ++Y+ +F +  +  E       ++ Y +  L
Sbjct: 520  AEARSETSITLSWSP--------PRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDL 571

Query: 453  RPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEK------IYIQW 506
            +P      RL   +P+G      +V Q          L+SI    F+ K      + + W
Sbjct: 572  KPNTEYAFRLAARSPQGLGAFTPVVRQRT--------LQSISPKNFKVKMIMKTSVLLSW 623

Query: 507  KPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTI 566
            + P+  N   T Y+I Y  + +LD                  T  L   L P T Y+F +
Sbjct: 624  EFPDNYNSP-TPYKIQYNGL-TLDVDG-------------RTTKKLITHLKPHTFYNFVL 668

Query: 567  --KASTAKGFGPPVTTRIATKI--SAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVS 622
              + S+  G    VT   A  +    PS+       P  + D  I V L   QS   PV 
Sbjct: 669  TNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQS---PVP 719

Query: 623  VYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANL------PVT 676
            V    +    L+KSR        F  P+       L+ L    + L+  +L       V 
Sbjct: 720  VQSYFIVMVPLRKSRGGQ-----FLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVP 774

Query: 677  QPFTV------------GDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLAT 724
            +P+              GD K Y G+ N  L P   Y ++  A+ + +  T       A+
Sbjct: 775  RPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFA-----AS 829

Query: 725  KGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLA 784
              +     +  +P+  VD    +  VI G ++ ++ ++ +++ I   +N        K  
Sbjct: 830  PFSDPFQLDNPDPQPIVDGEEGLIWVI-GPVLAVVFIICIVIAILLYKN--------KPD 880

Query: 785  KKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLT 844
             K+K+++               P TK   +  D                           
Sbjct: 881  SKRKDSE---------------PRTKCLLNNADLA------------------------- 900

Query: 845  IQTHPYRTCDPVEMSYPRDQFQ-------PAIRVADLLQHITQMKRGQGYGFKEEYEALP 897
                P+   DPVEM   R  FQ       P I +AD+ +H  ++K        +EYE++ 
Sbjct: 901  ----PHHPKDPVEMR--RINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 954

Query: 898  EGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHY 957
             GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  ++G   SDYINANY+DGY     Y
Sbjct: 955  PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1014

Query: 958  IATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLI 1016
            IATQGP+ ET  DFWRM+W++ SA+IVM+T L E  R+KC +YWP+  TE YG I+VTL+
Sbjct: 1015 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1074

Query: 1017 ETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPE 1076
            +T  LA + +RTF++ K G  E RE+R F FT+WPDHGVP Y T  L F+R+VK  NPP+
Sbjct: 1075 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1134

Query: 1077 AGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFV 1136
            AGPIVVHCSAG GRTGCFI ID ML+  + E  VD++  V  +R+QR  +VQTE+QY F+
Sbjct: 1135 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1194

Query: 1137 HDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSI 1196
            H+A+LEA  CGNT +P     +    +++++P  + + ++ EF+ L     +        
Sbjct: 1195 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFIS 1252

Query: 1197 GLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPN 1255
              LP N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++ TQ PL  
Sbjct: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312

Query: 1256 TVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDII 1313
            T  DFWR++++ N + VVML ++     + C QYWP + S  Y    V+ ++       I
Sbjct: 1313 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYI 1372

Query: 1314 HRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGR 1373
             R F++ +    Q   R V+  Q+  WP  +  P S    +  + ++ K +EQ+ G++G 
Sbjct: 1373 LREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF-GQDGP 1428

Query: 1374 TVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEV 1433
              VHC  G GR+G F  +  V E ++ + ++D+F  VK LR  +  MV+T ++Y+F Y+ 
Sbjct: 1429 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQA 1488

Query: 1434 ALEYLSSF 1441
            ALEYL SF
Sbjct: 1489 ALEYLGSF 1496



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 106/412 (25%), Positives = 171/412 (41%), Gaps = 49/412 (11%)

Query: 190 RKAPHFLRL-QNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRF 248
           R AP F  L  + E+  G N    C+A G    + K W+Q   G +       +   R  
Sbjct: 229 RVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK-WMQ---GAEDLTPEDDMPVGRNV 284

Query: 249 SATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL 305
                V D+A      Y CV  S  G  +   A++ VK  P     P   E  A   T  
Sbjct: 285 LELTDVKDSAN-----YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITIT 338

Query: 306 WIKPNANSIIGDGPIILKEVEYRTTT--GTWAETHIVDSPNYKLWHLDPDVEYEIRVLLT 363
           W   N +      P+    +EY++ +  G +     + +  Y +  L P+ EYEI V  +
Sbjct: 339 WDSGNPD------PVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--S 390

Query: 364 RPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHS 419
                G GPP   + TRT    P   P+NV+   + A  + +QW    EP G  + R + 
Sbjct: 391 AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNG--LIRGYR 448

Query: 420 YNLTVQYQY-VFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVV 478
              T++ ++ V N Q++  ++ + T+    L       T+R+    S  +G + S+ + V
Sbjct: 449 VYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLED--ETYTVRVLAFTSVGDGPL-SDPIQV 505

Query: 479 QTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQ 538
           +T++ VPG  P+        E  I + W PP + +  I  YE+ ++         D   +
Sbjct: 506 KTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFR-------EGDHGRE 555

Query: 539 RGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFG---PPVTTRIATKIS 587
            G+ F     T ++   L P T Y+F + A + +G G   P V  R    IS
Sbjct: 556 VGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSIS 605


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score =  495 bits (1275), Expect = e-139
 Identities = 354/1096 (32%), Positives = 535/1096 (48%), Gaps = 146/1096 (13%)

Query: 386  PVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSS 445
            P   PQN+      +  + L W+P   A         T+ Y+ +        + ++   +
Sbjct: 918  PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT 977

Query: 446  HYTLRGLRPFMTIRLRLLLSNPEGRME-SEELVVQTEEDVPGAVPLESIQGGPFEEK--- 501
              TL GL+P  T  +++     +G    S  +  +T       +P++ +    F  K   
Sbjct: 978  TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVM 1030

Query: 502  ---IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADLSSQRGKVFKLRNETHHLFVG 555
               + + W+ P   N  +  ++I Y   K V  +D  A               T  L V 
Sbjct: 1031 KTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA---------------TQKLIVN 1074

Query: 556  LYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKP 613
            L P  +YSF +  + ++A G    VT + A  +   + P +   T L   D  ITV L  
Sbjct: 1075 LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPAFIGKTNL---DGMITVQLPE 1130

Query: 614  AQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSL------------ 661
              +       Y ++V    L+KSR        F  P    +   LD L            
Sbjct: 1131 VPANENIKGYYIIIVP---LKKSRGK------FIKPWESPDEMELDELLKEISRKRRSIR 1181

Query: 662  HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKI 717
            +    ELKP   A+  V    FT+GD+K Y G+ N  L   + Y ++F      + E+K+
Sbjct: 1182 YGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKM 1240

Query: 718  NCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLL--MFIIILLGVMLTIKRRRNAY 775
                  +  +    S  ++P+   D    +  V+  +L  +FII ++  +L  KR+R   
Sbjct: 1241 YAT---SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKR--- 1294

Query: 776  SYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSR 835
                                        A+  + K S   N E                 
Sbjct: 1295 ----------------------------AESDSRKSSIPNNKE----------------- 1309

Query: 836  GELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRVADLLQHITQMKRGQGYGFK 890
                     I +H     DPVE+       P     P I + +L  HI ++K      F 
Sbjct: 1310 ---------IPSH--HPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFS 1358

Query: 891  EEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDG 950
            +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  ++G P SDY+NANYIDG
Sbjct: 1359 QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG 1418

Query: 951  YHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYG 1009
            Y +   YIATQG + ET  DFWRMIW++ SA++VM+T L E  RVKC +YWP   TE +G
Sbjct: 1419 YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHG 1478

Query: 1010 DIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQV 1069
             ++VTL++T  LA Y +RTF + K G  E RE+R F FT+WPDHGVP + T  L F+R+V
Sbjct: 1479 LVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRV 1538

Query: 1070 KFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQT 1129
            K  NPP+AGP+VVHCSAG GRTGCFI ID ML+  ++E  VDI+  V  +RAQR  +VQT
Sbjct: 1539 KTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQT 1598

Query: 1130 EEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP-QTNSSQIKDEFQTLNIVTPR 1188
            E+QY+F+HDA+LEA  CGNT +P    R+LY  I +L   +T  +    E +   + + +
Sbjct: 1599 EDQYIFIHDALLEAVTCGNTEVPA---RNLYAYIQKLTQIETGENVTGMELEFKRLASSK 1655

Query: 1189 VRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFV 1247
                      LP N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++
Sbjct: 1656 AHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYI 1715

Query: 1248 VTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVS 1305
             TQ PL  T  DFWR+++++N + VVML ++     + C QYWP + S  Y    V+ ++
Sbjct: 1716 ATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA 1775

Query: 1306 ADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQE 1365
                   I R F++ +    Q   R V+  Q+  WP  +  P S    +  + ++ K +E
Sbjct: 1776 EYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKE 1832

Query: 1366 QYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLE 1425
            Q+ G++G   VHC  G GR+G F  +  V E ++ + ++D+F  VK LR  +  MV+T +
Sbjct: 1833 QF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED 1891

Query: 1426 QYKFVYEVALEYLSSF 1441
            QY+F Y  ALEYL SF
Sbjct: 1892 QYQFSYRAALEYLGSF 1907



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 93/378 (24%), Positives = 152/378 (40%), Gaps = 36/378 (9%)

Query: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316
           R  + Y CV  S  G  +   A++ VK  P P   P   E  A   T  W   N   +  
Sbjct: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 351

Query: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
                + + + + +   + E   V +  Y +  L P  +YE RV+       G GPP  P
Sbjct: 352 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 407

Query: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432
           + T+T    P   P++V+   + +  + +QW    EP G  +     Y      Q+V N 
Sbjct: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 466

Query: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490
            ++     +  S   T+  L P  T  +++L   S  +G + S+  V+ T+  VPG  PL
Sbjct: 467 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 520

Query: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550
                   E  I + W PP   +  I  YE+ YK  G       ++ + G  ++L+    
Sbjct: 521 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 573

Query: 551 HLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIA-TKISAPSMPEYDTD-TPLNETDTTIT 608
               GL P + Y F + A + +G G       A T  S PS P  D   T  + T   ++
Sbjct: 574 ----GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 629

Query: 609 VMLKPAQSRGAPVSVYQL 626
               P + +   ++ Y +
Sbjct: 630 WQPPPVEKQNGIITEYSI 647



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 83/353 (23%), Positives = 137/353 (38%), Gaps = 30/353 (8%)

Query: 253 SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306
           SVA  +  S  ++R V  ++ G G  +   L       P + P       L +      W
Sbjct: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438

Query: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366
            +P   +    G  +   ++       W + ++ DS    + +L P   Y ++VL     
Sbjct: 439 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 496

Query: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
             G GP    +   T+   P   P N +        + L W P           +    Y
Sbjct: 497 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 547

Query: 427 QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE-ELVVQTEED 483
           + V+   ++  E+   I+  + Y L+GL+P      RL   +P+G   S  E+  +T + 
Sbjct: 548 ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607

Query: 484 VPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLDPSADLSSQRGK 541
            P A P +     P    I + W+PP   + NG+IT Y I Y AV   D       +  +
Sbjct: 608 KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGED------DKPHE 661

Query: 542 VFKLRNE-THHLFVGLYPGTTYSFTIKASTAKGFGP-PVTTRIATKISAPSMP 592
           +  + ++ T +L   L   T Y  T+ A T  G GP  ++  I T    PS P
Sbjct: 662 ILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 714



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 82/346 (23%), Positives = 126/346 (36%), Gaps = 54/346 (15%)

Query: 263  SKYRCVI--RSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL---WIKPNANSI 314
            ++YR  +   +D G G  + + LI      P  PP   E+ AV +T +   W  P  N  
Sbjct: 681  TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 740

Query: 315  IGD-----------------GPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357
             G                  G  +LK+V        + +T   D     +  L P+  Y 
Sbjct: 741  HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI---ISGLQPETSYS 797

Query: 358  IRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTR 416
            + V   T  G+G    P    TT       V G   + I   +     +QW P       
Sbjct: 798  LTVTAYTTKGDGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHP------P 846

Query: 417  CHSYNLTVQYQYVFNQQQYEAEEVIQTSS---HYTLRGLRPFMTIRLRLLLSNPEGRMES 473
              ++     Y+  F ++  E    ++ S    H+T   +    +   RL   N  G  E 
Sbjct: 847  VDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEE 906

Query: 474  EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVG-SLD 530
                +   E+VP   P      G     + + W+PP   E NG+IT Y + Y+ +   L 
Sbjct: 907  MVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLL 966

Query: 531  PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGP 576
            P   L         +  +T     GL P TTY   ++A T+KG GP
Sbjct: 967  PMEQLI--------VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 1004



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 91/409 (22%), Positives = 154/409 (37%), Gaps = 66/409 (16%)

Query: 261 SVSKYRCVIRSDGGSGVSNYAELIVKEPPT-PIAPPELLAVGATYLWIKPNANSII---- 315
           S+  +R   RS  G G S  AE+  +   + P APP+ ++  +      P++ SI+    
Sbjct: 579 SLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTS------PSSTSILVSWQ 631

Query: 316 ------GDGPIILKEVEYRTTTGTWAETHIV-----DSPNYKLWHLDPDVEYEIRVLLTR 364
                  +G I    ++Y    G   + H +     D+  Y L  L+   EY  R+ +T 
Sbjct: 632 PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RITVTA 689

Query: 365 PGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEP----------FGYAV 414
             + G GP    +  RT    P   P+ VE+  + +  + + W             GY V
Sbjct: 690 HTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 749

Query: 415 TRCHSYNLTVQYQYVFNQ-----QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEG 469
                 N   + Q +         Q+E ++   T     + GL+P  +  L +     +G
Sbjct: 750 HYVRMENGEPKGQPMLKDVMLADAQWEFDDT--TEHDMIISGLQPETSYSLTVTAYTTKG 807

Query: 470 R-MESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGS 528
               S+  +V T   VPG   L  +          IQW PP +T G +  Y + +     
Sbjct: 808 DGARSKPKLVSTTGAVPGKPRL--VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRK-D 864

Query: 529 LDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISA 588
           ++P   L            E H     ++ G +Y F + A    GFG      +  +IS 
Sbjct: 865 MEPLTTLEFSE-------KEDHFTATDIHKGASYVFRLSARNKVGFG----EEMVKEISI 913

Query: 589 PSMPEYDTDTPLN-----ETDTTITVMLKP--AQSRGAPVSVYQLVVKE 630
           P   E  T  P N      T T++ +  +P     R   ++ Y L+ ++
Sbjct: 914 PE--EVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 960


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score =  495 bits (1275), Expect = e-139
 Identities = 354/1096 (32%), Positives = 535/1096 (48%), Gaps = 146/1096 (13%)

Query: 386  PVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSS 445
            P   PQN+      +  + L W+P   A         T+ Y+ +        + ++   +
Sbjct: 905  PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT 964

Query: 446  HYTLRGLRPFMTIRLRLLLSNPEGRME-SEELVVQTEEDVPGAVPLESIQGGPFEEK--- 501
              TL GL+P  T  +++     +G    S  +  +T       +P++ +    F  K   
Sbjct: 965  TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVM 1017

Query: 502  ---IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADLSSQRGKVFKLRNETHHLFVG 555
               + + W+ P   N  +  ++I Y   K V  +D  A               T  L V 
Sbjct: 1018 KTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA---------------TQKLIVN 1061

Query: 556  LYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKP 613
            L P  +YSF +  + ++A G    VT + A  +   + P +   T L   D  ITV L  
Sbjct: 1062 LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPAFIGKTNL---DGMITVQLPE 1117

Query: 614  AQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSL------------ 661
              +       Y ++V    L+KSR        F  P    +   LD L            
Sbjct: 1118 VPANENIKGYYIIIVP---LKKSRGK------FIKPWESPDEMELDELLKEISRKRRSIR 1168

Query: 662  HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKI 717
            +    ELKP   A+  V    FT+GD+K Y G+ N  L   + Y ++F      + E+K+
Sbjct: 1169 YGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKM 1227

Query: 718  NCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLL--MFIIILLGVMLTIKRRRNAY 775
                  +  +    S  ++P+   D    +  V+  +L  +FII ++  +L  KR+R   
Sbjct: 1228 YAT---SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKR--- 1281

Query: 776  SYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSR 835
                                        A+  + K S   N E                 
Sbjct: 1282 ----------------------------AESDSRKSSIPNNKE----------------- 1296

Query: 836  GELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRVADLLQHITQMKRGQGYGFK 890
                     I +H     DPVE+       P     P I + +L  HI ++K      F 
Sbjct: 1297 ---------IPSH--HPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFS 1345

Query: 891  EEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDG 950
            +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  ++G P SDY+NANYIDG
Sbjct: 1346 QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG 1405

Query: 951  YHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYG 1009
            Y +   YIATQG + ET  DFWRMIW++ SA++VM+T L E  RVKC +YWP   TE +G
Sbjct: 1406 YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHG 1465

Query: 1010 DIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQV 1069
             ++VTL++T  LA Y +RTF + K G  E RE+R F FT+WPDHGVP + T  L F+R+V
Sbjct: 1466 LVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRV 1525

Query: 1070 KFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQT 1129
            K  NPP+AGP+VVHCSAG GRTGCFI ID ML+  ++E  VDI+  V  +RAQR  +VQT
Sbjct: 1526 KTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQT 1585

Query: 1130 EEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP-QTNSSQIKDEFQTLNIVTPR 1188
            E+QY+F+HDA+LEA  CGNT +P    R+LY  I +L   +T  +    E +   + + +
Sbjct: 1586 EDQYIFIHDALLEAVTCGNTEVPA---RNLYAYIQKLTQIETGENVTGMELEFKRLASSK 1642

Query: 1189 VRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFV 1247
                      LP N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++
Sbjct: 1643 AHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYI 1702

Query: 1248 VTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVS 1305
             TQ PL  T  DFWR+++++N + VVML ++     + C QYWP + S  Y    V+ ++
Sbjct: 1703 ATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA 1762

Query: 1306 ADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQE 1365
                   I R F++ +    Q   R V+  Q+  WP  +  P S    +  + ++ K +E
Sbjct: 1763 EYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKE 1819

Query: 1366 QYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLE 1425
            Q+ G++G   VHC  G GR+G F  +  V E ++ + ++D+F  VK LR  +  MV+T +
Sbjct: 1820 QF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED 1878

Query: 1426 QYKFVYEVALEYLSSF 1441
            QY+F Y  ALEYL SF
Sbjct: 1879 QYQFSYRAALEYLGSF 1894



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 93/378 (24%), Positives = 152/378 (40%), Gaps = 36/378 (9%)

Query: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316
           R  + Y CV  S  G  +   A++ VK  P P   P   E  A   T  W   N   +  
Sbjct: 282 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 338

Query: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
                + + + + +   + E   V +  Y +  L P  +YE RV+       G GPP  P
Sbjct: 339 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 394

Query: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432
           + T+T    P   P++V+   + +  + +QW    EP G  +     Y      Q+V N 
Sbjct: 395 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 453

Query: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490
            ++     +  S   T+  L P  T  +++L   S  +G + S+  V+ T+  VPG  PL
Sbjct: 454 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 507

Query: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550
                   E  I + W PP   +  I  YE+ YK  G       ++ + G  ++L+    
Sbjct: 508 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 560

Query: 551 HLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIA-TKISAPSMPEYDTD-TPLNETDTTIT 608
               GL P + Y F + A + +G G       A T  S PS P  D   T  + T   ++
Sbjct: 561 ----GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 616

Query: 609 VMLKPAQSRGAPVSVYQL 626
               P + +   ++ Y +
Sbjct: 617 WQPPPVEKQNGIITEYSI 634



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 83/353 (23%), Positives = 137/353 (38%), Gaps = 30/353 (8%)

Query: 253 SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306
           SVA  +  S  ++R V  ++ G G  +   L       P + P       L +      W
Sbjct: 366 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 425

Query: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366
            +P   +    G  +   ++       W + ++ DS    + +L P   Y ++VL     
Sbjct: 426 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 483

Query: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
             G GP    +   T+   P   P N +        + L W P           +    Y
Sbjct: 484 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 534

Query: 427 QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE-ELVVQTEED 483
           + V+   ++  E+   I+  + Y L+GL+P      RL   +P+G   S  E+  +T + 
Sbjct: 535 ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 594

Query: 484 VPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLDPSADLSSQRGK 541
            P A P +     P    I + W+PP   + NG+IT Y I Y AV   D       +  +
Sbjct: 595 KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGED------DKPHE 648

Query: 542 VFKLRNE-THHLFVGLYPGTTYSFTIKASTAKGFGP-PVTTRIATKISAPSMP 592
           +  + ++ T +L   L   T Y  T+ A T  G GP  ++  I T    PS P
Sbjct: 649 ILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 701



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 82/346 (23%), Positives = 126/346 (36%), Gaps = 54/346 (15%)

Query: 263 SKYRCVI--RSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL---WIKPNANSI 314
           ++YR  +   +D G G  + + LI      P  PP   E+ AV +T +   W  P  N  
Sbjct: 668 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 727

Query: 315 IGD-----------------GPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357
            G                  G  +LK+V        + +T   D     +  L P+  Y 
Sbjct: 728 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI---ISGLQPETSYS 784

Query: 358 IRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTR 416
           + V   T  G+G    P    TT       V G   + I   +     +QW P       
Sbjct: 785 LTVTAYTTKGDGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHP------P 833

Query: 417 CHSYNLTVQYQYVFNQQQYEAEEVIQTSS---HYTLRGLRPFMTIRLRLLLSNPEGRMES 473
             ++     Y+  F ++  E    ++ S    H+T   +    +   RL   N  G  E 
Sbjct: 834 VDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEE 893

Query: 474 EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVG-SLD 530
               +   E+VP   P      G     + + W+PP   E NG+IT Y + Y+ +   L 
Sbjct: 894 MVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLL 953

Query: 531 PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGP 576
           P   L         +  +T     GL P TTY   ++A T+KG GP
Sbjct: 954 PMEQLI--------VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 991



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 91/409 (22%), Positives = 154/409 (37%), Gaps = 66/409 (16%)

Query: 261 SVSKYRCVIRSDGGSGVSNYAELIVKEPPT-PIAPPELLAVGATYLWIKPNANSII---- 315
           S+  +R   RS  G G S  AE+  +   + P APP+ ++  +      P++ SI+    
Sbjct: 566 SLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTS------PSSTSILVSWQ 618

Query: 316 ------GDGPIILKEVEYRTTTGTWAETHIV-----DSPNYKLWHLDPDVEYEIRVLLTR 364
                  +G I    ++Y    G   + H +     D+  Y L  L+   EY  R+ +T 
Sbjct: 619 PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RITVTA 676

Query: 365 PGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEP----------FGYAV 414
             + G GP    +  RT    P   P+ VE+  + +  + + W             GY V
Sbjct: 677 HTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 736

Query: 415 TRCHSYNLTVQYQYVFNQ-----QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEG 469
                 N   + Q +         Q+E ++   T     + GL+P  +  L +     +G
Sbjct: 737 HYVRMENGEPKGQPMLKDVMLADAQWEFDDT--TEHDMIISGLQPETSYSLTVTAYTTKG 794

Query: 470 R-MESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGS 528
               S+  +V T   VPG   L  +          IQW PP +T G +  Y + +     
Sbjct: 795 DGARSKPKLVSTTGAVPGKPRL--VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRK-D 851

Query: 529 LDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISA 588
           ++P   L            E H     ++ G +Y F + A    GFG      +  +IS 
Sbjct: 852 MEPLTTLEFSE-------KEDHFTATDIHKGASYVFRLSARNKVGFG----EEMVKEISI 900

Query: 589 PSMPEYDTDTPLN-----ETDTTITVMLKP--AQSRGAPVSVYQLVVKE 630
           P   E  T  P N      T T++ +  +P     R   ++ Y L+ ++
Sbjct: 901 PE--EVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 947


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score =  495 bits (1275), Expect = e-139
 Identities = 354/1096 (32%), Positives = 535/1096 (48%), Gaps = 146/1096 (13%)

Query: 386  PVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSS 445
            P   PQN+      +  + L W+P   A         T+ Y+ +        + ++   +
Sbjct: 909  PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT 968

Query: 446  HYTLRGLRPFMTIRLRLLLSNPEGRME-SEELVVQTEEDVPGAVPLESIQGGPFEEK--- 501
              TL GL+P  T  +++     +G    S  +  +T       +P++ +    F  K   
Sbjct: 969  TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVM 1021

Query: 502  ---IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADLSSQRGKVFKLRNETHHLFVG 555
               + + W+ P   N  +  ++I Y   K V  +D  A               T  L V 
Sbjct: 1022 KTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA---------------TQKLIVN 1065

Query: 556  LYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKP 613
            L P  +YSF +  + ++A G    VT + A  +   + P +   T L   D  ITV L  
Sbjct: 1066 LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPAFIGKTNL---DGMITVQLPE 1121

Query: 614  AQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSL------------ 661
              +       Y ++V    L+KSR        F  P    +   LD L            
Sbjct: 1122 VPANENIKGYYIIIVP---LKKSRGK------FIKPWESPDEMELDELLKEISRKRRSIR 1172

Query: 662  HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKI 717
            +    ELKP   A+  V    FT+GD+K Y G+ N  L   + Y ++F      + E+K+
Sbjct: 1173 YGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKM 1231

Query: 718  NCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLL--MFIIILLGVMLTIKRRRNAY 775
                  +  +    S  ++P+   D    +  V+  +L  +FII ++  +L  KR+R   
Sbjct: 1232 YAT---SPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKR--- 1285

Query: 776  SYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSR 835
                                        A+  + K S   N E                 
Sbjct: 1286 ----------------------------AESDSRKSSIPNNKE----------------- 1300

Query: 836  GELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRVADLLQHITQMKRGQGYGFK 890
                     I +H     DPVE+       P     P I + +L  HI ++K      F 
Sbjct: 1301 ---------IPSH--HPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFS 1349

Query: 891  EEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDG 950
            +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  ++G P SDY+NANYIDG
Sbjct: 1350 QEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDG 1409

Query: 951  YHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYG 1009
            Y +   YIATQG + ET  DFWRMIW++ SA++VM+T L E  RVKC +YWP   TE +G
Sbjct: 1410 YRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHG 1469

Query: 1010 DIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQV 1069
             ++VTL++T  LA Y +RTF + K G  E RE+R F FT+WPDHGVP + T  L F+R+V
Sbjct: 1470 LVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRV 1529

Query: 1070 KFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQT 1129
            K  NPP+AGP+VVHCSAG GRTGCFI ID ML+  ++E  VDI+  V  +RAQR  +VQT
Sbjct: 1530 KTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQT 1589

Query: 1130 EEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP-QTNSSQIKDEFQTLNIVTPR 1188
            E+QY+F+HDA+LEA  CGNT +P    R+LY  I +L   +T  +    E +   + + +
Sbjct: 1590 EDQYIFIHDALLEAVTCGNTEVPA---RNLYAYIQKLTQIETGENVTGMELEFKRLASSK 1646

Query: 1189 VRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFV 1247
                      LP N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++
Sbjct: 1647 AHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYI 1706

Query: 1248 VTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVS 1305
             TQ PL  T  DFWR+++++N + VVML ++     + C QYWP + S  Y    V+ ++
Sbjct: 1707 ATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMA 1766

Query: 1306 ADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQE 1365
                   I R F++ +    Q   R V+  Q+  WP  +  P S    +  + ++ K +E
Sbjct: 1767 EYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKE 1823

Query: 1366 QYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLE 1425
            Q+ G++G   VHC  G GR+G F  +  V E ++ + ++D+F  VK LR  +  MV+T +
Sbjct: 1824 QF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED 1882

Query: 1426 QYKFVYEVALEYLSSF 1441
            QY+F Y  ALEYL SF
Sbjct: 1883 QYQFSYRAALEYLGSF 1898



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 93/378 (24%), Positives = 152/378 (40%), Gaps = 36/378 (9%)

Query: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316
           R  + Y CV  S  G  +   A++ VK  P P   P   E  A   T  W   N   +  
Sbjct: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 351

Query: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
                + + + + +   + E   V +  Y +  L P  +YE RV+       G GPP  P
Sbjct: 352 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 407

Query: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432
           + T+T    P   P++V+   + +  + +QW    EP G  +     Y      Q+V N 
Sbjct: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 466

Query: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490
            ++     +  S   T+  L P  T  +++L   S  +G + S+  V+ T+  VPG  PL
Sbjct: 467 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 520

Query: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550
                   E  I + W PP   +  I  YE+ YK  G       ++ + G  ++L+    
Sbjct: 521 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 573

Query: 551 HLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIA-TKISAPSMPEYDTD-TPLNETDTTIT 608
               GL P + Y F + A + +G G       A T  S PS P  D   T  + T   ++
Sbjct: 574 ----GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 629

Query: 609 VMLKPAQSRGAPVSVYQL 626
               P + +   ++ Y +
Sbjct: 630 WQPPPVEKQNGIITEYSI 647



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 83/353 (23%), Positives = 137/353 (38%), Gaps = 30/353 (8%)

Query: 253 SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306
           SVA  +  S  ++R V  ++ G G  +   L       P + P       L +      W
Sbjct: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438

Query: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366
            +P   +    G  +   ++       W + ++ DS    + +L P   Y ++VL     
Sbjct: 439 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 496

Query: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
             G GP    +   T+   P   P N +        + L W P           +    Y
Sbjct: 497 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 547

Query: 427 QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE-ELVVQTEED 483
           + V+   ++  E+   I+  + Y L+GL+P      RL   +P+G   S  E+  +T + 
Sbjct: 548 ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607

Query: 484 VPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLDPSADLSSQRGK 541
            P A P +     P    I + W+PP   + NG+IT Y I Y AV   D       +  +
Sbjct: 608 KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGED------DKPHE 661

Query: 542 VFKLRNE-THHLFVGLYPGTTYSFTIKASTAKGFGP-PVTTRIATKISAPSMP 592
           +  + ++ T +L   L   T Y  T+ A T  G GP  ++  I T    PS P
Sbjct: 662 ILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 714



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 82/336 (24%), Positives = 127/336 (37%), Gaps = 43/336 (12%)

Query: 263 SKYRCVI--RSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL---WIKPNANSI 314
           ++YR  +   +D G G  + + LI      P  PP   E+ AV +T +   W  P  N  
Sbjct: 681 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK- 739

Query: 315 IGDGPIILKEVEY-RTTTGT------WAETHIVDSPNYKLWHLDPDVEYEIRVLL-TRPG 366
              G I   +V Y R   G         +  + D+ +  +  L P+  Y + V   T  G
Sbjct: 740 -QHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKG 798

Query: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
           +G    P    TT       V G   + I   +     +QW P         ++     Y
Sbjct: 799 DGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHP------PVDTFGPLQGY 847

Query: 427 QYVFNQQQYEAEEVIQTSS---HYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEED 483
           +  F ++  E    ++ S    H+T   +    +   RL   N  G  E     +   E+
Sbjct: 848 RLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEE 907

Query: 484 VPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVG-SLDPSADLSSQRG 540
           VP   P      G     + + W+PP   E NG+IT Y + Y+ +   L P   L     
Sbjct: 908 VPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLI---- 963

Query: 541 KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGP 576
               +  +T     GL P TTY   ++A T+KG GP
Sbjct: 964 ----VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 995



 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 88/400 (22%), Positives = 152/400 (38%), Gaps = 57/400 (14%)

Query: 261 SVSKYRCVIRSDGGSGVSNYAELIVKEPPT-PIAPPELLAVGATYLWIKPNANSII---- 315
           S+  +R   RS  G G S  AE+  +   + P APP+ ++  +      P++ SI+    
Sbjct: 579 SLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTS------PSSTSILVSWQ 631

Query: 316 ------GDGPIILKEVEYRTTTGTWAETHIV-----DSPNYKLWHLDPDVEYEIRVLLTR 364
                  +G I    ++Y    G   + H +     D+  Y L  L+   EY  R+ +T 
Sbjct: 632 PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RITVTA 689

Query: 365 PGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTV 424
             + G GP    +  RT    P   P+ VE+  + +  + + W        + H      
Sbjct: 690 HTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWR--SPVPNKQHGQIRGY 747

Query: 425 QYQYVFNQ------QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGR-MESEELV 477
           Q  YV  +      Q    + ++  +    + GL+P  +  L +     +G    S+  +
Sbjct: 748 QVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKL 807

Query: 478 VQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSS 537
           V T   VPG   L  +          IQW PP +T G +  Y + +     ++P   L  
Sbjct: 808 VSTTGAVPGKPRL--VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRK-DMEPLTTLEF 864

Query: 538 QRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTD 597
                     E H     ++ G +Y F + A    GFG      +  +IS P   E  T 
Sbjct: 865 SE-------KEDHFTATDIHKGASYVFRLSARNKVGFG----EEMVKEISIPE--EVPTG 911

Query: 598 TPLN-----ETDTTITVMLKP--AQSRGAPVSVYQLVVKE 630
            P N      T T++ +  +P     R   ++ Y L+ ++
Sbjct: 912 FPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 951


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score =  480 bits (1236), Expect = e-135
 Identities = 323/973 (33%), Positives = 490/973 (50%), Gaps = 128/973 (13%)

Query: 502  IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561
            + + W+ P+  N   T Y+I Y  + +LD                  T  L   L P T 
Sbjct: 1028 VLLSWEFPDNYNSP-TPYKIQYNGL-TLDVDG-------------RTTKKLITHLKPHTF 1072

Query: 562  YSFTI--KASTAKGFGPPVTTRIATKI--SAPSMPEYDTDTPLNETDTTITVMLKPAQSR 617
            Y+F +  + S+  G    VT   A  +    PS+       P  + D  I V L   QS 
Sbjct: 1073 YNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQS- 1125

Query: 618  GAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANL---- 673
              PV V    +    L+KSR        F  P+       L+ L    + L+  +L    
Sbjct: 1126 --PVPVQSYFIVMVPLRKSRGGQ-----FLTPLGSPEDMDLEELIQDISRLQRRSLRHSR 1178

Query: 674  --PVTQPFTV------------GDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINC 719
               V +P+              GD K Y G+ N  L P   Y ++  A+ + +  T    
Sbjct: 1179 QLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFA-- 1236

Query: 720  VRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSY 779
               A+  +     +  +P+  VD    +  VI G ++ ++ ++ +++ I   +N      
Sbjct: 1237 ---ASPFSDPFQLDNPDPQPIVDGEEGLIWVI-GPVLAVVFIICIVIAILLYKN------ 1286

Query: 780  YLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELS 839
              K   K+K+++               P TK   +  D                      
Sbjct: 1287 --KPDSKRKDSE---------------PRTKCLLNNADLA-------------------- 1309

Query: 840  QPTLTIQTHPYRTCDPVEMSYPRDQFQ-------PAIRVADLLQHITQMKRGQGYGFKEE 892
                     P+   DPVEM   R  FQ       P I +AD+ +H  ++K        +E
Sbjct: 1310 ---------PHHPKDPVEMR--RINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQE 1358

Query: 893  YEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYH 952
            YE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  ++G   SDYINANY+DGY 
Sbjct: 1359 YESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYR 1418

Query: 953  RPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDI 1011
                YIATQGP+ ET  DFWRM+W++ SA+IVM+T L E  R+KC +YWP+  TE YG I
Sbjct: 1419 CQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFI 1478

Query: 1012 KVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKF 1071
            +VTL++T  LA + +RTF++ K G  E RE+R F FT+WPDHGVP Y T  L F+R+VK 
Sbjct: 1479 QVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT 1538

Query: 1072 LNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEE 1131
             NPP+AGPIVVHCSAG GRTGCFI ID ML+  + E  VD++  V  +R+QR  +VQTE+
Sbjct: 1539 CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTED 1598

Query: 1132 QYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRP 1191
            QY F+H+A+LEA  CGNT +P     +    +++++P  + + ++ EF+ L     +   
Sbjct: 1599 QYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHT 1656

Query: 1192 EDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQ 1250
                   LP N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++ TQ
Sbjct: 1657 SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQ 1716

Query: 1251 HPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADI 1308
             PL  T  DFWR++++ N + VVML ++     + C QYWP + S  Y    V+ ++   
Sbjct: 1717 GPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN 1776

Query: 1309 DEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYD 1368
                I R F++ +    Q   R V+  Q+  WP  +  P S    +  + ++ K +EQ+ 
Sbjct: 1777 MPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF- 1832

Query: 1369 GREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYK 1428
            G++G   VHC  G GR+G F  +  V E ++ + ++D+F  VK LR  +  MV+T ++Y+
Sbjct: 1833 GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQ 1892

Query: 1429 FVYEVALEYLSSF 1441
            F Y+ ALEYL SF
Sbjct: 1893 FCYQAALEYLGSF 1905



 Score = 87.8 bits (216), Expect = 7e-17
 Identities = 114/437 (26%), Positives = 182/437 (41%), Gaps = 50/437 (11%)

Query: 190 RKAPHFLRL-QNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRF 248
           R AP F  L  + E+  G N    C+A G    + K W+Q   G +       +   R  
Sbjct: 229 RVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK-WMQ---GAEDLTPEDDMPVGRNV 284

Query: 249 SATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL 305
                V D+A      Y CV  S  G  +   A++ VK  P     P   E  A   T  
Sbjct: 285 LELTDVKDSAN-----YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITIT 338

Query: 306 WIKPNANSIIGDGPIILKEVEYRTTT--GTWAETHIVDSPNYKLWHLDPDVEYEIRVLLT 363
           W   N +      P+    +EY++ +  G +     + +  Y +  L P+ EYEI V  +
Sbjct: 339 WDSGNPD------PVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--S 390

Query: 364 RPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHS 419
                G GPP   + TRT    P   P+NV+   + A  + +QW    EP G  + R + 
Sbjct: 391 AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNG--LIRGYR 448

Query: 420 YNLTVQYQY-VFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVV 478
              T++ ++ V N Q++  ++ + T+    L       T+R+    S  +G + S+ + V
Sbjct: 449 VYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLED--ETYTVRVLAFTSVGDGPL-SDPIQV 505

Query: 479 QTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQ 538
           +T++ VPG  P+        E  I + W PP + +  I  YE+ ++         D   +
Sbjct: 506 KTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFR-------EGDHGRE 555

Query: 539 RGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFG--PPVTTRIATKISAPSMPEYDT 596
            G+ F     T ++   L P T Y+F + A + +G G   PV  R  T  S PS P  D 
Sbjct: 556 VGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV-VRQRTLQSKPSAPPQDV 612

Query: 597 DTPLNETDTTITVMLKP 613
              ++   T I V  +P
Sbjct: 613 KC-VSVRSTAILVSWRP 628



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 83/351 (23%), Positives = 124/351 (35%), Gaps = 26/351 (7%)

Query: 275 SGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTW 334
           S V+   E      P  +    L A      W +P   + +  G  +   +E     G W
Sbjct: 403 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNW 462

Query: 335 AETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVE 394
            + ++ DS    +  L  D  Y +RVL       G GP   P+  +T+   P   P N+ 
Sbjct: 463 QKHNVDDSLLTTVGSLLEDETYTVRVLAFT--SVGDGPLSDPIQVKTQQGVPGQ-PMNLR 519

Query: 395 IVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQY--EAEEVIQTSSHYTLRGL 452
                   +TL W P              ++Y+ +F +  +  E       ++ Y +  L
Sbjct: 520 AEARSETSITLSWSP--------PRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDL 571

Query: 453 RPFMTIRLRLLLSNPEGRMESEELVVQ-TEEDVPGAVPLESIQGGPFEEKIYIQWKPPN- 510
           +P      RL   +P+G      +V Q T +  P A P +          I + W+PP  
Sbjct: 572 KPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPP 631

Query: 511 ET-NGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKAS 569
           ET NG +  Y + Y+ +GS DP     +           T  L   L   T Y  T  A 
Sbjct: 632 ETHNGALVGYSVRYRPLGSEDPEPKEVNGIPP-----TTTQILLEALEKWTQYRITTVAH 686

Query: 570 TAKGFGP---PVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSR 617
           T  G GP   PV  R  T    PS P    +           +   PA  R
Sbjct: 687 TEVGPGPESSPVVVR--TDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 735



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 86/354 (24%), Positives = 128/354 (36%), Gaps = 35/354 (9%)

Query: 251  TVSVADTAQRSVSKYRC--VIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGAT-- 303
            T  +   A    ++YR   V  ++ G G  +   ++  +   P APP   E  A+ AT  
Sbjct: 665  TTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAI 724

Query: 304  -YLWIKPNANSIIGDGPIILKEVEYRTTTGTWA-------ETHIVDSPNYKLWHLDPDVE 355
              LW  P        G I   +V Y    G  A       +  + D+    + +L P+  
Sbjct: 725  RVLWRSPAPGR--QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETA 782

Query: 356  YEIRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEP-FGYA 413
            Y I V   T  G+G    P   +T       P    Q      + AR     WEP  G A
Sbjct: 783  YSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLAR-----WEPPAGTA 837

Query: 414  VTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMES 473
              +   Y L    +   +       E   +   YT  G+    T   RL   +  G  E 
Sbjct: 838  EDQVLGYRLQFGRE---DSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEE 894

Query: 474  EELVVQTEEDVPGAVP-LESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLD 530
               V+   ED P   P +    G      + ++W PP   E NG I  Y +  +  G+L 
Sbjct: 895  AAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALG 954

Query: 531  PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKG---FGPPVTTR 581
            P+ +  ++     +   E      GL P T Y   ++A T +G   F PPV  R
Sbjct: 955  PARE--TELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYR 1006


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score =  476 bits (1225), Expect = e-134
 Identities = 319/966 (33%), Positives = 494/966 (51%), Gaps = 98/966 (10%)

Query: 502  IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561
            + + W+ P+  N   T Y+I Y  + +LD                  T  L   L P T 
Sbjct: 1050 VLLSWEFPDNYNSP-TPYKIQYNGL-TLDVDG-------------RTTKKLITHLKPHTF 1094

Query: 562  YSFTI--KASTAKGFGPPVTTRIATKI--SAPSMPEYDTDTPLNETDTTITVMLKPAQSR 617
            Y+F +  + S+  G    VT   A  +    PS+       P  + D  I V L   QS 
Sbjct: 1095 YNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQS- 1147

Query: 618  GAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANL---- 673
              PV V    +    L+KSR        F  P+       L+ L    + L+  +L    
Sbjct: 1148 --PVPVQSYFIVMVPLRKSRGGQ-----FLTPLGSPEDMDLEELIQDISRLQRRSLRHSR 1200

Query: 674  --PVTQPFTV------------GDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINC 719
               V +P+              GD K Y G+ N  L P   Y ++  A+ + +  T    
Sbjct: 1201 QLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFA-- 1258

Query: 720  VRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSY 779
               A+  +     +  +P+  VD    +  VI G ++ ++ ++ +++ I   +N      
Sbjct: 1259 ---ASPFSDPFQLDNPDPQPIVDGEEGLIWVI-GPVLAVVFIICIVIAILLYKN------ 1308

Query: 780  YLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELS 839
              K   K+K+++    R    + +AD     L+     +       +      G R  L 
Sbjct: 1309 --KPDSKRKDSEP---RTKCLLNNAD-----LAPHHPKDPVEMRRINFQTPDSGLRSPLR 1358

Query: 840  QPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEG 899
            +P    ++          +S+P       I +AD+ +H  ++K        +EYE++  G
Sbjct: 1359 EPGFHFESM---------LSHP------PIPIADMAEHTERLKANDSLKLSQEYESIDPG 1403

Query: 900  QTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIA 959
            Q  +W+ +  + N+ KNRY N+I+YDHSRV L  ++G   SDYINANY+DGY     YIA
Sbjct: 1404 QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIA 1463

Query: 960  TQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIET 1018
            TQGP+ ET  DFWRM+W++ SA+IVM+T L E  R+KC +YWP+  TE YG I+VTL++T
Sbjct: 1464 TQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDT 1523

Query: 1019 EPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAG 1078
              LA + +RTF++ K G  E RE+R F FT+WPDHGVP Y T  L F+R+VK  NPP+AG
Sbjct: 1524 IELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAG 1583

Query: 1079 PIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHD 1138
            PIVVHCSAG GRTGCFI ID ML+  + E  VD++  V  +R+QR  +VQTE+QY F+H+
Sbjct: 1584 PIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHE 1643

Query: 1139 AILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGL 1198
            A+LEA  CGNT +P     +    +++++P  + + ++ EF+ L     +          
Sbjct: 1644 ALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFISAN 1701

Query: 1199 LPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTV 1257
            LP N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++ TQ PL  T 
Sbjct: 1702 LPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1761

Query: 1258 ADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHR 1315
             DFWR++++ N + VVML ++     + C QYWP + S  Y    V+ ++       I R
Sbjct: 1762 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1821

Query: 1316 IFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTV 1375
             F++ +    Q   R V+  Q+  WP  +  P S    +  + ++ K +EQ+ G++G   
Sbjct: 1822 EFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF-GQDGPIS 1877

Query: 1376 VHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVAL 1435
            VHC  G GR+G F  +  V E ++ + ++D+F  VK LR  +  MV+T ++Y+F Y+ AL
Sbjct: 1878 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL 1937

Query: 1436 EYLSSF 1441
            EYL SF
Sbjct: 1938 EYLGSF 1943



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 117/445 (26%), Positives = 185/445 (41%), Gaps = 50/445 (11%)

Query: 182 VRVLAHPCRKAPHFLRL-QNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT 240
           VR L    R AP F  L  + E+  G N    C+A G    + K W+Q   G +      
Sbjct: 234 VRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK-WMQ---GAEDLTPED 289

Query: 241 RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---EL 297
            +   R       V D+A      Y CV  S  G  +   A++ VK  P     P   E 
Sbjct: 290 DMPVGRNVLELTDVKDSAN-----YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTEN 343

Query: 298 LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTT--GTWAETHIVDSPNYKLWHLDPDVE 355
            A   T  W   N +      P+    +EY++ +  G +     + +  Y +  L P+ E
Sbjct: 344 TATSITITWDSGNPD------PVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSE 397

Query: 356 YEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFG 411
           YEI V  +     G GPP   + TRT    P   P+NV+   + A  + +QW    EP G
Sbjct: 398 YEIWV--SAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNG 455

Query: 412 YAVTRCHSYNLTVQYQY-VFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGR 470
             + R +    T++ ++ V N Q++  ++ + T+    L       T+R+    S  +G 
Sbjct: 456 --LIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLED--ETYTVRVLAFTSVGDGP 511

Query: 471 MESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLD 530
           + S+ + V+T++ VPG  P+        E  I + W PP + +  I  YE+ ++      
Sbjct: 512 L-SDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFR------ 561

Query: 531 PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFG--PPVTTRIATKISA 588
              D   + G+ F     T ++   L P T Y+F + A + +G G   PV  R  T  S 
Sbjct: 562 -EGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV-VRQRTLQSK 617

Query: 589 PSMPEYDTDTPLNETDTTITVMLKP 613
           PS P  D    ++   T I V  +P
Sbjct: 618 PSAPPQDVKC-VSVRSTAILVSWRP 641



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 83/351 (23%), Positives = 124/351 (35%), Gaps = 26/351 (7%)

Query: 275 SGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTW 334
           S V+   E      P  +    L A      W +P   + +  G  +   +E     G W
Sbjct: 416 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNW 475

Query: 335 AETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVE 394
            + ++ DS    +  L  D  Y +RVL       G GP   P+  +T+   P   P N+ 
Sbjct: 476 QKHNVDDSLLTTVGSLLEDETYTVRVLAFT--SVGDGPLSDPIQVKTQQGVPGQ-PMNLR 532

Query: 395 IVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQY--EAEEVIQTSSHYTLRGL 452
                   +TL W P              ++Y+ +F +  +  E       ++ Y +  L
Sbjct: 533 AEARSETSITLSWSP--------PRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDL 584

Query: 453 RPFMTIRLRLLLSNPEGRMESEELVVQ-TEEDVPGAVPLESIQGGPFEEKIYIQWKPPN- 510
           +P      RL   +P+G      +V Q T +  P A P +          I + W+PP  
Sbjct: 585 KPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPP 644

Query: 511 ET-NGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKAS 569
           ET NG +  Y + Y+ +GS DP     +           T  L   L   T Y  T  A 
Sbjct: 645 ETHNGALVGYSVRYRPLGSEDPEPKEVNGIPP-----TTTQILLEALEKWTQYRITTVAH 699

Query: 570 TAKGFGP---PVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSR 617
           T  G GP   PV  R  T    PS P    +           +   PA  R
Sbjct: 700 TEVGPGPESSPVVVR--TDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 748



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 87/364 (23%), Positives = 129/364 (35%), Gaps = 46/364 (12%)

Query: 251  TVSVADTAQRSVSKYRC--VIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGAT-- 303
            T  +   A    ++YR   V  ++ G G  +   ++  +   P APP   E  A+ AT  
Sbjct: 678  TTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAI 737

Query: 304  -YLWIKPNANSIIGDGPIILKEVEYRTTTGTWA-------ETHIVDSPNYKLWHLDPDVE 355
              LW  P        G I   +V Y    G  A       +  + D+     W  D   E
Sbjct: 738  RVLWRSPAPGR--QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQ----WETDDTAE 791

Query: 356  YEIRVLLTRPGEG-----------GTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLT 404
            YE+ +   +P              G G    P    TK A  V G   + +       L 
Sbjct: 792  YEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGA--VLGRPTLSVQQTPEGSLL 849

Query: 405  LQWEP-FGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL 463
             +WEP  G A  +   Y L    +   +       E   +   YT  G+    T   RL 
Sbjct: 850  ARWEPPAGTAEDQVLGYRLQFGRE---DSTPLATLEFPPSEDRYTASGVHKGATYVFRLA 906

Query: 464  LSNPEGRMESEELVVQTEEDVPGAVP-LESIQGGPFEEKIYIQWKPP--NETNGVITLYE 520
              +  G  E    V+   ED P   P +    G      + ++W PP   E NG I  Y 
Sbjct: 907  ARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYT 966

Query: 521  INYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKG---FGPP 577
            +  +  G+L P+ +  ++     +   E      GL P T Y   ++A T +G   F PP
Sbjct: 967  VAVREAGALGPARE--TELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPP 1024

Query: 578  VTTR 581
            V  R
Sbjct: 1025 VRYR 1028


>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  434 bits (1117), Expect = e-121
 Identities = 231/584 (39%), Positives = 352/584 (60%), Gaps = 16/584 (2%)

Query: 867  PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYD 925
            P + V  L + I +        F+EE+ ALP     A+ + A ++EN+ KNRY NI+ YD
Sbjct: 210  PPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYD 269

Query: 926  HSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVM 985
            HSRV L  ++G P SDYINA++I+GY     +IA QGP +ETV DFWRMIW++N+A+IVM
Sbjct: 270  HSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVM 329

Query: 986  VTNLVEVGRVKCVRYWPDD-TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRE--- 1041
            VTNL E    KC +YWPD     YG+I+V++ +   L +Y +R F +Q+ G    R+   
Sbjct: 330  VTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQR 389

Query: 1042 -LRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTM 1100
             +  FHFTSWPD GVP    G+L F+++VK  NP  AG IVVHCSAG GRTG F+ ID M
Sbjct: 390  LITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAM 449

Query: 1101 LDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLY 1160
            LDM   E  VD++  V  +RAQR  +VQT+ QYVF++ A+LE  L G+T + V    +  
Sbjct: 450  LDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL 509

Query: 1161 YNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLD-RCLP 1219
              I    P T+++ +++EF+ L  +  +++ +    G LP N  KNR + ++P +   + 
Sbjct: 510  QKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVI 567

Query: 1220 FLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMD 1279
              +    E+++Y+NA+ +D ++Q  +++ +Q PL +T+ DFWR+++++   S+VML E++
Sbjct: 568  IPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELE 627

Query: 1280 T--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQY 1337
                + C QYWP      YG I VE    +  E    R   + N    ++  R ++   +
Sbjct: 628  ERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTR--ENKSRQIRQFHF 685

Query: 1338 IGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEM 1397
             GWP     P   + ++ ++  ++K Q+Q  G    T VHC  G GR+GTFCA+ +V E 
Sbjct: 686  HGWPEV-GIPSDGKGMISIIAAVQK-QQQQSGNHPIT-VHCSAGAGRTGTFCALSTVLER 742

Query: 1398 IQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1441
            ++ + I+DVF  VK+LR  + +MV+TLEQY+F Y+V  EY+ +F
Sbjct: 743  VKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF 786


>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
            precursor [Homo sapiens]
          Length = 802

 Score =  434 bits (1117), Expect = e-121
 Identities = 231/584 (39%), Positives = 352/584 (60%), Gaps = 16/584 (2%)

Query: 867  PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYD 925
            P + V  L + I +        F+EE+ ALP     A+ + A ++EN+ KNRY NI+ YD
Sbjct: 219  PPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYD 278

Query: 926  HSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVM 985
            HSRV L  ++G P SDYINA++I+GY     +IA QGP +ETV DFWRMIW++N+A+IVM
Sbjct: 279  HSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVM 338

Query: 986  VTNLVEVGRVKCVRYWPDD-TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRE--- 1041
            VTNL E    KC +YWPD     YG+I+V++ +   L +Y +R F +Q+ G    R+   
Sbjct: 339  VTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQR 398

Query: 1042 -LRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTM 1100
             +  FHFTSWPD GVP    G+L F+++VK  NP  AG IVVHCSAG GRTG F+ ID M
Sbjct: 399  LITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAM 458

Query: 1101 LDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLY 1160
            LDM   E  VD++  V  +RAQR  +VQT+ QYVF++ A+LE  L G+T + V    +  
Sbjct: 459  LDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL 518

Query: 1161 YNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLD-RCLP 1219
              I    P T+++ +++EF+ L  +  +++ +    G LP N  KNR + ++P +   + 
Sbjct: 519  QKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVI 576

Query: 1220 FLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMD 1279
              +    E+++Y+NA+ +D ++Q  +++ +Q PL +T+ DFWR+++++   S+VML E++
Sbjct: 577  IPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELE 636

Query: 1280 T--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQY 1337
                + C QYWP      YG I VE    +  E    R   + N    ++  R ++   +
Sbjct: 637  ERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTR--ENKSRQIRQFHF 694

Query: 1338 IGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEM 1397
             GWP     P   + ++ ++  ++K Q+Q  G    T VHC  G GR+GTFCA+ +V E 
Sbjct: 695  HGWPEV-GIPSDGKGMISIIAAVQK-QQQQSGNHPIT-VHCSAGAGRTGTFCALSTVLER 751

Query: 1398 IQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1441
            ++ + I+DVF  VK+LR  + +MV+TLEQY+F Y+V  EY+ +F
Sbjct: 752  VKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF 795


>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  434 bits (1117), Expect = e-121
 Identities = 231/584 (39%), Positives = 352/584 (60%), Gaps = 16/584 (2%)

Query: 867  PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYD 925
            P + V  L + I +        F+EE+ ALP     A+ + A ++EN+ KNRY NI+ YD
Sbjct: 210  PPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYD 269

Query: 926  HSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVM 985
            HSRV L  ++G P SDYINA++I+GY     +IA QGP +ETV DFWRMIW++N+A+IVM
Sbjct: 270  HSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVM 329

Query: 986  VTNLVEVGRVKCVRYWPDD-TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRE--- 1041
            VTNL E    KC +YWPD     YG+I+V++ +   L +Y +R F +Q+ G    R+   
Sbjct: 330  VTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQR 389

Query: 1042 -LRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTM 1100
             +  FHFTSWPD GVP    G+L F+++VK  NP  AG IVVHCSAG GRTG F+ ID M
Sbjct: 390  LITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAM 449

Query: 1101 LDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLY 1160
            LDM   E  VD++  V  +RAQR  +VQT+ QYVF++ A+LE  L G+T + V    +  
Sbjct: 450  LDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL 509

Query: 1161 YNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLD-RCLP 1219
              I    P T+++ +++EF+ L  +  +++ +    G LP N  KNR + ++P +   + 
Sbjct: 510  QKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVI 567

Query: 1220 FLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMD 1279
              +    E+++Y+NA+ +D ++Q  +++ +Q PL +T+ DFWR+++++   S+VML E++
Sbjct: 568  IPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELE 627

Query: 1280 T--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQY 1337
                + C QYWP      YG I VE    +  E    R   + N    ++  R ++   +
Sbjct: 628  ERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTR--ENKSRQIRQFHF 685

Query: 1338 IGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEM 1397
             GWP     P   + ++ ++  ++K Q+Q  G    T VHC  G GR+GTFCA+ +V E 
Sbjct: 686  HGWPEV-GIPSDGKGMISIIAAVQK-QQQQSGNHPIT-VHCSAGAGRTGTFCALSTVLER 742

Query: 1398 IQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1441
            ++ + I+DVF  VK+LR  + +MV+TLEQY+F Y+V  EY+ +F
Sbjct: 743  VKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF 786


>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
            precursor [Homo sapiens]
          Length = 700

 Score =  421 bits (1082), Expect = e-117
 Identities = 230/564 (40%), Positives = 334/564 (59%), Gaps = 16/564 (2%)

Query: 889  FKEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANY 947
            F+EE+ +LP G    +++ A ++ENR KNRY NI+  DHSRV L  LDG P SDYINA+Y
Sbjct: 135  FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 194

Query: 948  IDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD-TE 1006
            IDGY     +IA QGP QETV DFWRM+W++ SA+IVM+TNL E    KC +YWPD    
Sbjct: 195  IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 254

Query: 1007 VYGDIKVTLIETEPLAEYVIRTFTVQKK---GYHEIRELRLFHFTSWPDHGVPCYATGLL 1063
             YG+I+V + +   L +Y IR F +Q +   G    R +   HFTSWPD GVP    G+L
Sbjct: 255  TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 314

Query: 1064 GFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQR 1123
             F+++VK LNP  AGPIVVHCSAG GRTG FI ID M+ M   E  VD+F  V  +R QR
Sbjct: 315  KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 374

Query: 1124 VNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLN 1183
              +VQT+ QY F++ A+LE  L G+T + V         +       +   +++EF+ L 
Sbjct: 375  PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 434

Query: 1184 IVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQ 1242
             V  R+  E+   G LP N  K R + ++P D     L    G E ++YINA+ +D ++Q
Sbjct: 435  NV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 492

Query: 1243 PAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQ--FCMQYWPEKTSGCYGPIQ 1300
               F+ TQ PL +TV DFWR+++++   ++VML E+   +   C QYWP + S  +G I 
Sbjct: 493  KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEIT 552

Query: 1301 VEFVSADIDEDIIHRIFRIC---NMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVV 1357
            +E  +  + E I  R F +      AR ++  R+V+   + GWP     P   + ++ ++
Sbjct: 553  IEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDLI 611

Query: 1358 RRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNK 1417
              ++K Q+Q         VHC  G GR+GTF A+ ++ E ++ + ++DVF  VK+LR  +
Sbjct: 612  AAVQKQQQQTGNHP--ITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQR 669

Query: 1418 SNMVETLEQYKFVYEVALEYLSSF 1441
             +MV+TLEQY+F Y+V  +++  F
Sbjct: 670  PHMVQTLEQYEFCYKVVQDFIDIF 693


>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
            [Homo sapiens]
          Length = 642

 Score =  421 bits (1082), Expect = e-117
 Identities = 230/564 (40%), Positives = 334/564 (59%), Gaps = 16/564 (2%)

Query: 889  FKEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANY 947
            F+EE+ +LP G    +++ A ++ENR KNRY NI+  DHSRV L  LDG P SDYINA+Y
Sbjct: 77   FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 136

Query: 948  IDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD-TE 1006
            IDGY     +IA QGP QETV DFWRM+W++ SA+IVM+TNL E    KC +YWPD    
Sbjct: 137  IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 196

Query: 1007 VYGDIKVTLIETEPLAEYVIRTFTVQKK---GYHEIRELRLFHFTSWPDHGVPCYATGLL 1063
             YG+I+V + +   L +Y IR F +Q +   G    R +   HFTSWPD GVP    G+L
Sbjct: 197  TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 256

Query: 1064 GFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQR 1123
             F+++VK LNP  AGPIVVHCSAG GRTG FI ID M+ M   E  VD+F  V  +R QR
Sbjct: 257  KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 316

Query: 1124 VNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLN 1183
              +VQT+ QY F++ A+LE  L G+T + V         +       +   +++EF+ L 
Sbjct: 317  PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 376

Query: 1184 IVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQ 1242
             V  R+  E+   G LP N  K R + ++P D     L    G E ++YINA+ +D ++Q
Sbjct: 377  NV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 434

Query: 1243 PAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQ--FCMQYWPEKTSGCYGPIQ 1300
               F+ TQ PL +TV DFWR+++++   ++VML E+   +   C QYWP + S  +G I 
Sbjct: 435  KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEIT 494

Query: 1301 VEFVSADIDEDIIHRIFRIC---NMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVV 1357
            +E  +  + E I  R F +      AR ++  R+V+   + GWP     P   + ++ ++
Sbjct: 495  IEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDLI 553

Query: 1358 RRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNK 1417
              ++K Q+Q         VHC  G GR+GTF A+ ++ E ++ + ++DVF  VK+LR  +
Sbjct: 554  AAVQKQQQQTGNHP--ITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQR 611

Query: 1418 SNMVETLEQYKFVYEVALEYLSSF 1441
             +MV+TLEQY+F Y+V  +++  F
Sbjct: 612  PHMVQTLEQYEFCYKVVQDFIDIF 635


>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
            precursor [Homo sapiens]
          Length = 2315

 Score =  394 bits (1012), Expect = e-109
 Identities = 233/631 (36%), Positives = 356/631 (56%), Gaps = 59/631 (9%)

Query: 847  THPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPE-------- 898
            T P     P    +P      AI +    +H+  +    G  F EE+E L E        
Sbjct: 1677 TSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSG--FTEEFETLKEFYQEVQSC 1734

Query: 899  ----GQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVL---DGDPHSDYINANYIDGY 951
                G TA  D++   +N++KNRY NI++YDHSRV+L  L   DG   +DYINANY+DGY
Sbjct: 1735 TVDLGITA--DSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKL-TDYINANYVDGY 1791

Query: 952  HRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP-DDTEVYGD 1010
            +RP+ YIA QGP++ T +DFWRMIW+ N   IVM+TNLVE GR KC +YWP D +E YG+
Sbjct: 1792 NRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGN 1851

Query: 1011 IKVTLIETEPLAEYVIRTFTVQ--------KKGYHEIRELRLFHFTSWPDHGVPCYATGL 1062
              VT    + LA Y +R FT++        +KG    R +  +H+T WPD GVP Y+  +
Sbjct: 1852 FLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPV 1911

Query: 1063 LGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQ 1122
            L FVR+  +      GP+VVHCSAG GRTG +I +D+ML   ++EG V+IF  ++ +R+Q
Sbjct: 1912 LTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQ 1971

Query: 1123 RVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTL 1182
            R  LVQTEEQYVF+HD ++EA L   T +      + Y N   +      ++++ +FQ L
Sbjct: 1972 RNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHA-YVNALLIPGPAGKTKLEKQFQLL 2030

Query: 1183 NIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQ 1242
            +     ++  D S  L   N +KNR+  ++P++R    + S+ GE ++YINA+ +  + Q
Sbjct: 2031 S--QSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQ 2088

Query: 1243 PAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNE-MDTAQFCMQYWPEKTSGCYGPIQV 1301
               F++TQHPL +T+ DFWR+++D+N   VVM+ +  + A+    YWP K      PI  
Sbjct: 2089 SNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDE----PINC 2144

Query: 1302 EFVSADI----------DEDIIHRIFRICNMARPQDGYRI-VQHLQYIGWPAYRDTPPSK 1350
            E     +          +E +I + F    +   QD Y + V+H Q   WP   D+P SK
Sbjct: 2145 ESFKVTLMAEEHKCLSNEEKLIIQDF---ILEATQDDYVLEVRHFQCPKWP-NPDSPISK 2200

Query: 1351 R-SLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHI 1409
               L+ V++      E+   R+G  +VH  +GG  +GTFCA+ ++   ++++N +DV+ +
Sbjct: 2201 TFELISVIK------EEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQV 2254

Query: 1410 VKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1440
             K +   +  +   +EQY+F+Y+V L  +S+
Sbjct: 2255 AKMINLMRPGVFADIEQYQFLYKVILSLVST 2285


>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
            [Homo sapiens]
          Length = 1445

 Score =  380 bits (976), Expect = e-105
 Identities = 230/657 (35%), Positives = 359/657 (54%), Gaps = 54/657 (8%)

Query: 812  SASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRV 871
            S  R ++G     Q  + + + S      P  +I   P     P +M         AI V
Sbjct: 783  SGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPI----PDDME--------AIPV 830

Query: 872  ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKED---ENRNKNRYGNIISYDHSR 928
               ++HI ++     +GF E++E +         TA+     EN++KNRY NI++YDHSR
Sbjct: 831  KQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSR 890

Query: 929  VRLLVLDG--DPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMV 986
            V+L  L G    HSDYINANY+DGY++ + YIATQGP++ T +DFWRMIW++N+  IVM+
Sbjct: 891  VKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMI 950

Query: 987  TNLVEVGRVKCVRYWP-DDTEVYGDIKVTLIETEPLAEYVIRTFTVQK-----------K 1034
            TNLVE GR KC +YWP +++E YG+I VTL  T+  A Y +R F+++            K
Sbjct: 951  TNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPK 1010

Query: 1035 GYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCF 1094
            G    R +  +H+T WPD GVP YA  +L FVR+      PE GP++VHCSAG GRTG +
Sbjct: 1011 GRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTY 1070

Query: 1095 IAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVC 1154
            I ID+ML   +++  V++   ++ +R QR  LVQTEEQY+F+HDA+LEA L   T +   
Sbjct: 1071 IVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSN 1130

Query: 1155 EFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPL 1214
            +  S Y N   +      ++++ +F+   +     +  +C       N +KNR+  V+P 
Sbjct: 1131 QLHS-YVNSILIPGVGGKTRLEKQFKL--VTQCNAKYVECFSAQKECNKEKNRNSSVVPS 1187

Query: 1215 DRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVV 1273
            +R    L  + G + ++YINA+ +  + +   F++TQHPLP+T  DFWR+++D+N   +V
Sbjct: 1188 ERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIV 1247

Query: 1274 ML-NEMDTAQFCMQYWP--EKTSGCYGPIQVEFVSAD------IDEDIIHRIFRICNMAR 1324
            ML +    A+    YWP  E++  C     V  +S D       ++ IIH       +  
Sbjct: 1248 MLPDNQSLAEDEFVYWPSREESMNCEA-FTVTLISKDRLCLSNEEQIIIHDFI----LEA 1302

Query: 1325 PQDGYRI-VQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGG 1383
             QD Y + V+H Q   WP       S   L+ V++      E+   R+G T+VH   G  
Sbjct: 1303 TQDDYVLEVRHFQCPKWPNPDAPISSTFELINVIK------EEALTRDGPTIVHDEYGAV 1356

Query: 1384 RSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1440
             +G  CA+ ++ + ++ +N +DVF + K +   +  +   +EQY+F+Y+  L  +S+
Sbjct: 1357 SAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST 1413


>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
            precursor [Homo sapiens]
          Length = 1256

 Score =  356 bits (913), Expect = 1e-97
 Identities = 219/628 (34%), Positives = 328/628 (52%), Gaps = 50/628 (7%)

Query: 848  HPYRTC--DPVEMSYPRDQFQPAIRV----ADLLQHITQMK-RGQGYGFKEEYEALPEGQ 900
            H  R+C  D  +    RD  +  + V    AD+L    + K   +G  F  E++++P   
Sbjct: 555  HKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVF 614

Query: 901  TA-SWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIA 959
            +      A++  N+NKNRY +I+ YD++RV L  ++GD  S+YINA+YIDG+  PR YIA
Sbjct: 615  SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA 674

Query: 960  TQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP---DDTEVYGDIKVTLI 1016
             QGP  ETV DFWRMIW++ +  IVMVT   E  R KC  YWP   + T  +GD+ V + 
Sbjct: 675  AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKIN 734

Query: 1017 ETEPLAEYVIRTFT-VQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPP 1075
            + +   +Y+I+    V KK     RE+    FTSWPDHGVP     LL   R+V   +  
Sbjct: 735  QHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF 794

Query: 1076 EAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVF 1135
             +GPIVVHCSAG GRTG +I ID ML+  E E  VD++  V +LR QR  +VQ E QY+ 
Sbjct: 795  FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYIL 854

Query: 1136 VHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRP-EDC 1194
            +H A++E    G T + + E     +N+ + DP +  S ++ EFQ L    P  R     
Sbjct: 855  IHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRL----PSYRSWRTQ 910

Query: 1195 SIGLLPRNHDKNRSMDVLPLD-RCLPFLISVD-------------------GESSNYINA 1234
             IG    N  KNR+ +V+P D   +P    ++                    E S YINA
Sbjct: 911  HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINA 970

Query: 1235 ALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKT 1292
            + + S+ +P   +  Q PL  T+ DFW+++F      +VML E+     + C QYW E  
Sbjct: 971  SFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK 1030

Query: 1293 SGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRS 1352
               YG I+V+    D       R+F + +  R     R V   QY  W +    P   + 
Sbjct: 1031 Q-TYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKE 1086

Query: 1353 LLKVVRRLEKWQEQYDGREGR-------TVVHCLNGGGRSGTFCAICSVCEMIQQQNIID 1405
            L+ +++ +++   Q +  EG         ++HC +G  ++G FCA+ ++ E  + + ++D
Sbjct: 1087 LISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVD 1146

Query: 1406 VFHIVKTLRNNKSNMVETLEQYKFVYEV 1433
            +F +VK LR  +  MV T EQY+F+Y+V
Sbjct: 1147 IFQVVKALRKARPGMVSTFEQYQFLYDV 1174



 Score =  165 bits (417), Expect = 3e-40
 Identities = 100/308 (32%), Positives = 162/308 (52%), Gaps = 38/308 (12%)

Query: 869  IRVADLLQHITQMKR----GQGYGFKEEYEALPEGQTASWDT---AKEDENRNKNRYGNI 921
            + +++L  ++  MK+     +    + E++ LP  +  SW T     ++EN++KNR  N+
Sbjct: 870  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYR--SWRTQHIGNQEENKSKNRNSNV 927

Query: 922  ISYDHSRVRLL---------VLDGDPHSD----------YINANYIDGYHRPRHYIATQG 962
            I YD++RV L            D D  SD          YINA++I  Y +P   IA QG
Sbjct: 928  IPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQG 987

Query: 963  PMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLA 1022
            P++ET+ DFW+MI+Q     IVM+T L    +  C +YW +  + YGDI+V L +T+  +
Sbjct: 988  PLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSS 1047

Query: 1023 EYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPE------ 1076
             Y +R F ++     + R +  + +T+W    +P     L+  ++ VK   P +      
Sbjct: 1048 TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 1107

Query: 1077 ----AGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQ 1132
                + P+++HC  G+ +TG F A+  +L+ AE E VVDIF  V+ LR  R  +V T EQ
Sbjct: 1108 KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1167

Query: 1133 YVFVHDAI 1140
            Y F++D I
Sbjct: 1168 YQFLYDVI 1175



 Score =  131 bits (330), Expect = 4e-30
 Identities = 79/243 (32%), Positives = 125/243 (51%), Gaps = 10/243 (4%)

Query: 1200 PRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVVTQHPLPNTVA 1258
            P N +KNR +D+LP D     L  ++G++ SNYINA+ +D  K+P  ++  Q P   TV 
Sbjct: 625  PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 684

Query: 1259 DFWRLVFDYNCSSVVMLN--EMDTAQFCMQYWPEKTSG--CYGPIQVEFVSADIDEDIIH 1314
            DFWR++++   + +VM+   E      C +YWP    G   +G + V+        D I 
Sbjct: 685  DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 744

Query: 1315 RIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRT 1374
            +   I N      G R V H+Q+  WP +   P     LLK+ RR+  +   + G     
Sbjct: 745  QKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAFSNFFSGP---I 799

Query: 1375 VVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVA 1434
            VVHC  G GR+GT+  I ++ E ++ +N +DV+  V  LR  +  MV+   QY  +++  
Sbjct: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859

Query: 1435 LEY 1437
            +EY
Sbjct: 860  VEY 862


>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
            precursor [Homo sapiens]
          Length = 1304

 Score =  356 bits (913), Expect = 1e-97
 Identities = 219/628 (34%), Positives = 328/628 (52%), Gaps = 50/628 (7%)

Query: 848  HPYRTC--DPVEMSYPRDQFQPAIRV----ADLLQHITQMK-RGQGYGFKEEYEALPEGQ 900
            H  R+C  D  +    RD  +  + V    AD+L    + K   +G  F  E++++P   
Sbjct: 603  HKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVF 662

Query: 901  TA-SWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIA 959
            +      A++  N+NKNRY +I+ YD++RV L  ++GD  S+YINA+YIDG+  PR YIA
Sbjct: 663  SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA 722

Query: 960  TQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP---DDTEVYGDIKVTLI 1016
             QGP  ETV DFWRMIW++ +  IVMVT   E  R KC  YWP   + T  +GD+ V + 
Sbjct: 723  AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKIN 782

Query: 1017 ETEPLAEYVIRTFT-VQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPP 1075
            + +   +Y+I+    V KK     RE+    FTSWPDHGVP     LL   R+V   +  
Sbjct: 783  QHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF 842

Query: 1076 EAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVF 1135
             +GPIVVHCSAG GRTG +I ID ML+  E E  VD++  V +LR QR  +VQ E QY+ 
Sbjct: 843  FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYIL 902

Query: 1136 VHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRP-EDC 1194
            +H A++E    G T + + E     +N+ + DP +  S ++ EFQ L    P  R     
Sbjct: 903  IHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRL----PSYRSWRTQ 958

Query: 1195 SIGLLPRNHDKNRSMDVLPLD-RCLPFLISVD-------------------GESSNYINA 1234
             IG    N  KNR+ +V+P D   +P    ++                    E S YINA
Sbjct: 959  HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINA 1018

Query: 1235 ALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKT 1292
            + + S+ +P   +  Q PL  T+ DFW+++F      +VML E+     + C QYW E  
Sbjct: 1019 SFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK 1078

Query: 1293 SGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRS 1352
               YG I+V+    D       R+F + +  R     R V   QY  W +    P   + 
Sbjct: 1079 Q-TYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKE 1134

Query: 1353 LLKVVRRLEKWQEQYDGREGR-------TVVHCLNGGGRSGTFCAICSVCEMIQQQNIID 1405
            L+ +++ +++   Q +  EG         ++HC +G  ++G FCA+ ++ E  + + ++D
Sbjct: 1135 LISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVD 1194

Query: 1406 VFHIVKTLRNNKSNMVETLEQYKFVYEV 1433
            +F +VK LR  +  MV T EQY+F+Y+V
Sbjct: 1195 IFQVVKALRKARPGMVSTFEQYQFLYDV 1222



 Score =  165 bits (417), Expect = 3e-40
 Identities = 100/308 (32%), Positives = 162/308 (52%), Gaps = 38/308 (12%)

Query: 869  IRVADLLQHITQMKR----GQGYGFKEEYEALPEGQTASWDT---AKEDENRNKNRYGNI 921
            + +++L  ++  MK+     +    + E++ LP  +  SW T     ++EN++KNR  N+
Sbjct: 918  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYR--SWRTQHIGNQEENKSKNRNSNV 975

Query: 922  ISYDHSRVRLL---------VLDGDPHSD----------YINANYIDGYHRPRHYIATQG 962
            I YD++RV L            D D  SD          YINA++I  Y +P   IA QG
Sbjct: 976  IPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQG 1035

Query: 963  PMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLA 1022
            P++ET+ DFW+MI+Q     IVM+T L    +  C +YW +  + YGDI+V L +T+  +
Sbjct: 1036 PLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSS 1095

Query: 1023 EYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPE------ 1076
             Y +R F ++     + R +  + +T+W    +P     L+  ++ VK   P +      
Sbjct: 1096 TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 1155

Query: 1077 ----AGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQ 1132
                + P+++HC  G+ +TG F A+  +L+ AE E VVDIF  V+ LR  R  +V T EQ
Sbjct: 1156 KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1215

Query: 1133 YVFVHDAI 1140
            Y F++D I
Sbjct: 1216 YQFLYDVI 1223



 Score =  131 bits (330), Expect = 4e-30
 Identities = 79/243 (32%), Positives = 125/243 (51%), Gaps = 10/243 (4%)

Query: 1200 PRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVVTQHPLPNTVA 1258
            P N +KNR +D+LP D     L  ++G++ SNYINA+ +D  K+P  ++  Q P   TV 
Sbjct: 673  PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 732

Query: 1259 DFWRLVFDYNCSSVVMLN--EMDTAQFCMQYWPEKTSG--CYGPIQVEFVSADIDEDIIH 1314
            DFWR++++   + +VM+   E      C +YWP    G   +G + V+        D I 
Sbjct: 733  DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 792

Query: 1315 RIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRT 1374
            +   I N      G R V H+Q+  WP +   P     LLK+ RR+  +   + G     
Sbjct: 793  QKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAFSNFFSGP---I 847

Query: 1375 VVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVA 1434
            VVHC  G GR+GT+  I ++ E ++ +N +DV+  V  LR  +  MV+   QY  +++  
Sbjct: 848  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907

Query: 1435 LEY 1437
            +EY
Sbjct: 908  VEY 910


>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
            precursor [Homo sapiens]
          Length = 1143

 Score =  356 bits (913), Expect = 1e-97
 Identities = 219/628 (34%), Positives = 328/628 (52%), Gaps = 50/628 (7%)

Query: 848  HPYRTC--DPVEMSYPRDQFQPAIRV----ADLLQHITQMK-RGQGYGFKEEYEALPEGQ 900
            H  R+C  D  +    RD  +  + V    AD+L    + K   +G  F  E++++P   
Sbjct: 442  HKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVF 501

Query: 901  TA-SWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIA 959
            +      A++  N+NKNRY +I+ YD++RV L  ++GD  S+YINA+YIDG+  PR YIA
Sbjct: 502  SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA 561

Query: 960  TQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP---DDTEVYGDIKVTLI 1016
             QGP  ETV DFWRMIW++ +  IVMVT   E  R KC  YWP   + T  +GD+ V + 
Sbjct: 562  AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKIN 621

Query: 1017 ETEPLAEYVIRTFT-VQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPP 1075
            + +   +Y+I+    V KK     RE+    FTSWPDHGVP     LL   R+V   +  
Sbjct: 622  QHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF 681

Query: 1076 EAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVF 1135
             +GPIVVHCSAG GRTG +I ID ML+  E E  VD++  V +LR QR  +VQ E QY+ 
Sbjct: 682  FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYIL 741

Query: 1136 VHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRP-EDC 1194
            +H A++E    G T + + E     +N+ + DP +  S ++ EFQ L    P  R     
Sbjct: 742  IHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRL----PSYRSWRTQ 797

Query: 1195 SIGLLPRNHDKNRSMDVLPLD-RCLPFLISVD-------------------GESSNYINA 1234
             IG    N  KNR+ +V+P D   +P    ++                    E S YINA
Sbjct: 798  HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINA 857

Query: 1235 ALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKT 1292
            + + S+ +P   +  Q PL  T+ DFW+++F      +VML E+     + C QYW E  
Sbjct: 858  SFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK 917

Query: 1293 SGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRS 1352
               YG I+V+    D       R+F + +  R     R V   QY  W +    P   + 
Sbjct: 918  Q-TYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKE 973

Query: 1353 LLKVVRRLEKWQEQYDGREGR-------TVVHCLNGGGRSGTFCAICSVCEMIQQQNIID 1405
            L+ +++ +++   Q +  EG         ++HC +G  ++G FCA+ ++ E  + + ++D
Sbjct: 974  LISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVD 1033

Query: 1406 VFHIVKTLRNNKSNMVETLEQYKFVYEV 1433
            +F +VK LR  +  MV T EQY+F+Y+V
Sbjct: 1034 IFQVVKALRKARPGMVSTFEQYQFLYDV 1061



 Score =  165 bits (417), Expect = 3e-40
 Identities = 100/308 (32%), Positives = 162/308 (52%), Gaps = 38/308 (12%)

Query: 869  IRVADLLQHITQMKR----GQGYGFKEEYEALPEGQTASWDT---AKEDENRNKNRYGNI 921
            + +++L  ++  MK+     +    + E++ LP  +  SW T     ++EN++KNR  N+
Sbjct: 757  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYR--SWRTQHIGNQEENKSKNRNSNV 814

Query: 922  ISYDHSRVRLL---------VLDGDPHSD----------YINANYIDGYHRPRHYIATQG 962
            I YD++RV L            D D  SD          YINA++I  Y +P   IA QG
Sbjct: 815  IPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQG 874

Query: 963  PMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLA 1022
            P++ET+ DFW+MI+Q     IVM+T L    +  C +YW +  + YGDI+V L +T+  +
Sbjct: 875  PLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSS 934

Query: 1023 EYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPE------ 1076
             Y +R F ++     + R +  + +T+W    +P     L+  ++ VK   P +      
Sbjct: 935  TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 994

Query: 1077 ----AGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQ 1132
                + P+++HC  G+ +TG F A+  +L+ AE E VVDIF  V+ LR  R  +V T EQ
Sbjct: 995  KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1054

Query: 1133 YVFVHDAI 1140
            Y F++D I
Sbjct: 1055 YQFLYDVI 1062



 Score =  131 bits (330), Expect = 4e-30
 Identities = 79/243 (32%), Positives = 125/243 (51%), Gaps = 10/243 (4%)

Query: 1200 PRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVVTQHPLPNTVA 1258
            P N +KNR +D+LP D     L  ++G++ SNYINA+ +D  K+P  ++  Q P   TV 
Sbjct: 512  PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 571

Query: 1259 DFWRLVFDYNCSSVVMLN--EMDTAQFCMQYWPEKTSG--CYGPIQVEFVSADIDEDIIH 1314
            DFWR++++   + +VM+   E      C +YWP    G   +G + V+        D I 
Sbjct: 572  DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 631

Query: 1315 RIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRT 1374
            +   I N      G R V H+Q+  WP +   P     LLK+ RR+  +   + G     
Sbjct: 632  QKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAFSNFFSGP---I 686

Query: 1375 VVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVA 1434
            VVHC  G GR+GT+  I ++ E ++ +N +DV+  V  LR  +  MV+   QY  +++  
Sbjct: 687  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746

Query: 1435 LEY 1437
            +EY
Sbjct: 747  VEY 749


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,888,014
Number of Sequences: 37866
Number of extensions: 2799849
Number of successful extensions: 10019
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 139
Number of HSP's successfully gapped in prelim test: 126
Number of HSP's that attempted gapping in prelim test: 7822
Number of HSP's gapped (non-prelim): 1292
length of query: 1441
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1326
effective length of database: 13,892,928
effective search space: 18422022528
effective search space used: 18422022528
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.