Search of human proteins with 148539858

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148539858 protein tyrosine phosphatase, receptor type, T
isoform 1 precursor [Homo sapiens]
         (1460 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148539858 protein tyrosine phosphatase, receptor type, T isof...  2991   0.0  
gi|148539860 protein tyrosine phosphatase, receptor type, T isof...  2941   0.0  
gi|157419150 protein tyrosine phosphatase, receptor type, M isof...  1956   0.0  
gi|157419152 protein tyrosine phosphatase, receptor type, M isof...  1951   0.0  
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo...  1757   0.0  
gi|208431815 protein tyrosine phosphatase, receptor type, K isof...  1751   0.0  
gi|110735402 protein tyrosine phosphatase, receptor type, U isof...  1554   0.0  
gi|110735404 protein tyrosine phosphatase, receptor type, U isof...  1537   0.0  
gi|110735406 protein tyrosine phosphatase, receptor type, U isof...  1530   0.0  
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...   504   e-142
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...   504   e-142
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...   504   e-142
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...   501   e-141
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...   490   e-138
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...   490   e-138
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...   490   e-138
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...   473   e-133
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...   473   e-133
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...   473   e-133
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...   468   e-131
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo...   434   e-121
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor...   434   e-121
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo...   434   e-121
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor...   421   e-117
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo...   421   e-117
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p...   394   e-109
gi|194097398 protein tyrosine phosphatase, receptor type, G prec...   380   e-105
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo...   356   1e-97
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo...   356   1e-97
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo...   356   1e-97

>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
            precursor [Homo sapiens]
          Length = 1460

 Score = 2991 bits (7755), Expect = 0.0
 Identities = 1460/1460 (100%), Positives = 1460/1460 (100%)

Query: 1    MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTW 60
            MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTW
Sbjct: 1    MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTW 60

Query: 61   EKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGAL 120
            EKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGAL
Sbjct: 61   EKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGAL 120

Query: 121  NVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVD 180
            NVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVD
Sbjct: 121  NVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVD 180

Query: 181  EVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT 240
            EVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT
Sbjct: 181  EVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT 240

Query: 241  RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAV 300
            RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAV
Sbjct: 241  RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAV 300

Query: 301  GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV 360
            GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV
Sbjct: 301  GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV 360

Query: 361  LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY 420
            LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY
Sbjct: 361  LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY 420

Query: 421  NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT 480
            NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT
Sbjct: 421  NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT 480

Query: 481  EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG 540
            EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG
Sbjct: 481  EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG 540

Query: 541  KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPL 600
            KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPL
Sbjct: 541  KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPL 600

Query: 601  NETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS 660
            NETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS
Sbjct: 601  NETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS 660

Query: 661  LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV 720
            LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV
Sbjct: 661  LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV 720

Query: 721  RLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIIL 780
            RLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIIL
Sbjct: 721  RLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIIL 780

Query: 781  LGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFS 840
            LGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFS
Sbjct: 781  LGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFS 840

Query: 841  SSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQM 900
            SSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQM
Sbjct: 841  SSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQM 900

Query: 901  KRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSD 960
            KRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSD
Sbjct: 901  KRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSD 960

Query: 961  YINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYW 1020
            YINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYW
Sbjct: 961  YINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYW 1020

Query: 1021 PDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATG 1080
            PDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATG
Sbjct: 1021 PDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATG 1080

Query: 1081 LLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRA 1140
            LLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRA
Sbjct: 1081 LLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRA 1140

Query: 1141 QRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQT 1200
            QRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQT
Sbjct: 1141 QRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQT 1200

Query: 1201 LNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHK 1260
            LNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHK
Sbjct: 1201 LNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHK 1260

Query: 1261 QPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQV 1320
            QPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQV
Sbjct: 1261 QPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQV 1320

Query: 1321 EFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLE 1380
            EFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLE
Sbjct: 1321 EFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLE 1380

Query: 1381 KWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMV 1440
            KWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMV
Sbjct: 1381 KWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMV 1440

Query: 1441 ETLEQYKFVYEVALEYLSSF 1460
            ETLEQYKFVYEVALEYLSSF
Sbjct: 1441 ETLEQYKFVYEVALEYLSSF 1460


>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
            precursor [Homo sapiens]
          Length = 1441

 Score = 2941 bits (7625), Expect = 0.0
 Identities = 1441/1460 (98%), Positives = 1441/1460 (98%), Gaps = 19/1460 (1%)

Query: 1    MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTW 60
            MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTW
Sbjct: 1    MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTW 60

Query: 61   EKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGAL 120
            EKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGAL
Sbjct: 61   EKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGAL 120

Query: 121  NVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVD 180
            NVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVD
Sbjct: 121  NVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVD 180

Query: 181  EVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT 240
            EVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT
Sbjct: 181  EVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT 240

Query: 241  RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAV 300
            RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAV
Sbjct: 241  RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAV 300

Query: 301  GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV 360
            GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV
Sbjct: 301  GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV 360

Query: 361  LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY 420
            LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY
Sbjct: 361  LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY 420

Query: 421  NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT 480
            NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT
Sbjct: 421  NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT 480

Query: 481  EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG 540
            EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG
Sbjct: 481  EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG 540

Query: 541  KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPL 600
            KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPL
Sbjct: 541  KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPL 600

Query: 601  NETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS 660
            NETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS
Sbjct: 601  NETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS 660

Query: 661  LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV 720
            LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV
Sbjct: 661  LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV 720

Query: 721  RLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIIL 780
            RLATK                   GASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIIL
Sbjct: 721  RLATK-------------------GASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIIL 761

Query: 781  LGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFS 840
            LGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFS
Sbjct: 762  LGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFS 821

Query: 841  SSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQM 900
            SSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQM
Sbjct: 822  SSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQM 881

Query: 901  KRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSD 960
            KRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSD
Sbjct: 882  KRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSD 941

Query: 961  YINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYW 1020
            YINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYW
Sbjct: 942  YINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYW 1001

Query: 1021 PDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATG 1080
            PDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATG
Sbjct: 1002 PDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATG 1061

Query: 1081 LLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRA 1140
            LLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRA
Sbjct: 1062 LLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRA 1121

Query: 1141 QRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQT 1200
            QRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQT
Sbjct: 1122 QRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQT 1181

Query: 1201 LNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHK 1260
            LNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHK
Sbjct: 1182 LNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHK 1241

Query: 1261 QPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQV 1320
            QPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQV
Sbjct: 1242 QPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQV 1301

Query: 1321 EFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLE 1380
            EFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLE
Sbjct: 1302 EFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLE 1361

Query: 1381 KWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMV 1440
            KWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMV
Sbjct: 1362 KWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMV 1421

Query: 1441 ETLEQYKFVYEVALEYLSSF 1460
            ETLEQYKFVYEVALEYLSSF
Sbjct: 1422 ETLEQYKFVYEVALEYLSSF 1441


>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
            precursor [Homo sapiens]
          Length = 1452

 Score = 1956 bits (5068), Expect = 0.0
 Identities = 945/1466 (64%), Positives = 1147/1466 (78%), Gaps = 61/1466 (4%)

Query: 23   ARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDQAVPTGSFMMVNSSGR 82
            A  ++ +GGC FDE YS CGYS + G + F WEQ+NT  KP  D  +P+GSFM+VN+SGR
Sbjct: 18   AAGETFSGGCLFDEPYSTCGYSQSEGDD-FNWEQVNTLTKPTSDPWMPSGSFMLVNASGR 76

Query: 83   ASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVV 142
              GQ+AHLLLP LKENDTHCIDFHY+ SS+  S PG LNVYVKVN GP GNP+WN+SG  
Sbjct: 77   PEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDP 136

Query: 143  TEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVE 202
            T  W +AELAISTFWP+FYQVIFE ++  GH GY+A+DEV+VL HPC + PHFLR+QNVE
Sbjct: 137  TRTWNRAELAISTFWPNFYQVIFEVIT-SGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVE 195

Query: 203  VNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSV 262
            VN GQ ATFQC A G+    D+LWLQ  + RD  L   +V + RRF A+ +V +T +R  
Sbjct: 196  VNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDA 255

Query: 263  SKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIIL 322
             KYRC+IR++GG G+SNYAEL+VKEPP PIAPP+L +VGATYLWI+ NANSI GDGPI+ 
Sbjct: 256  GKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVA 315

Query: 323  KEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTK 382
            +EVEY T +G+W +   VDS +YK+ HLDPD EYEI VLLTRPGEGGTG PGP L TRTK
Sbjct: 316  REVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTK 375

Query: 383  CADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVI- 441
            CADP+ GP+ +E+V++++RQ+T++WEPFGY VTRCHSYNLTV Y Y    Q+   EEV  
Sbjct: 376  CADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSW 435

Query: 442  -QTSSH--YTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPF 498
               +SH  +T+  L P+  + ++L+L NPEGR ES+EL+VQT+ED+PGAVP ESIQG  F
Sbjct: 436  DTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTF 495

Query: 499  EEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYP 558
            EEKI++QW+ P +T GVITLYEI YKAV S DP  DLS+Q G+V KL NETH LF GLYP
Sbjct: 496  EEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYP 555

Query: 559  GTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRG 618
            GTTYSFTI+ASTAKGFGPP T +  TKISAPSMP Y+ +TPLN+TD T+TVMLKPA SRG
Sbjct: 556  GTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRG 615

Query: 619  APVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQP 678
            APVSVYQ+VV+EER +++++  +I++C+ VP+ ++NAS L+S +YFAAE    +L   QP
Sbjct: 616  APVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQP 675

Query: 679  FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKAPMGSAQVTPGTP 738
            FT+GDNKTYNGYWN PL P KSY IYFQA S+ANGETKI+CV++ATK             
Sbjct: 676  FTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATK------------- 722

Query: 739  LCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSY 798
                  GA+T      EPEKQ D+TVK+AGVIAG+L+F+II LGV+L +K+R        
Sbjct: 723  ------GAATPKP-VPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKR-------- 767

Query: 799  YLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFS-SSSQDVNGFTDGSRGEL 857
              KLAKK+KET S  ++EM  + ++   +     +  DE FS   + ++NG +  S    
Sbjct: 768  --KLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSF 825

Query: 858  SQPTLT------------------------IQTHPYRTCDPVEMSYPRDQFQPAIRVADL 893
            +  T T                        +Q+H Y+  +P ++ Y   Q  PAIRVADL
Sbjct: 826  TMKTNTLSTSVPNSYYPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADL 885

Query: 894  LQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVL 953
            LQHITQMK  +GYGFKEEYE+  EGQ+A WD+AK+DENR KNRYGNII+YDHSRVRL  +
Sbjct: 886  LQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTI 945

Query: 954  DGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGR 1013
            +GD +SDYIN NYIDGYHRP HYIATQGPMQET+ DFWRM+W EN+ASI+MVTNLVEVGR
Sbjct: 946  EGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGR 1005

Query: 1014 VKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHG 1073
            VKC +YWPDDTE+Y DIKVTLIETE LAEYVIRTF V+K+G HEIRE+R FHFT WPDHG
Sbjct: 1006 VKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHG 1065

Query: 1074 VPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFN 1133
            VP +ATGLLGFVRQVK  +PP AGP+VVHCSAGAGRTGCFI ID MLDMAE EGVVDI+N
Sbjct: 1066 VPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYN 1125

Query: 1134 CVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQ 1193
            CVRELR++RVN+VQTEEQYVF+HDAILEACLCG+T++P  + RSLYY++++LDPQTNSSQ
Sbjct: 1126 CVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQ 1185

Query: 1194 IKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINA 1253
            IK+EF+TLN+VTP +R EDCSI LLPRNH+KNR MD+LP DRCLPFLI++DGESSNYINA
Sbjct: 1186 IKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINA 1245

Query: 1254 ALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSG 1313
            ALMDS+KQP+AF+VTQHPLPNTV DFWRLV DY+C+SVVMLN++D AQ C QYWPE    
Sbjct: 1246 ALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVH 1305

Query: 1314 CYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLL 1373
             +GPIQVEFVSAD++EDII RIFRI N ARPQDGYR+VQ  Q++GWP YRDTP SKRS L
Sbjct: 1306 RHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFL 1365

Query: 1374 KVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLR 1433
            K++R+++KWQE+Y+G EGRTVVHCLNGGGRSGTFCAI  VCEM++ Q  +DVFH VKTLR
Sbjct: 1366 KLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLR 1425

Query: 1434 NNKSNMVETLEQYKFVYEVALEYLSS 1459
            NNK NMV+ L+QYKF YEVALEYL+S
Sbjct: 1426 NNKPNMVDLLDQYKFCYEVALEYLNS 1451


>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
            precursor [Homo sapiens]
          Length = 1465

 Score = 1951 bits (5055), Expect = 0.0
 Identities = 945/1479 (63%), Positives = 1147/1479 (77%), Gaps = 74/1479 (5%)

Query: 23   ARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDQAVPTGSFMMVNSSGR 82
            A  ++ +GGC FDE YS CGYS + G + F WEQ+NT  KP  D  +P+GSFM+VN+SGR
Sbjct: 18   AAGETFSGGCLFDEPYSTCGYSQSEGDD-FNWEQVNTLTKPTSDPWMPSGSFMLVNASGR 76

Query: 83   ASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVV 142
              GQ+AHLLLP LKENDTHCIDFHY+ SS+  S PG LNVYVKVN GP GNP+WN+SG  
Sbjct: 77   PEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDP 136

Query: 143  TEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVE 202
            T  W +AELAISTFWP+FYQVIFE ++  GH GY+A+DEV+VL HPC + PHFLR+QNVE
Sbjct: 137  TRTWNRAELAISTFWPNFYQVIFEVIT-SGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVE 195

Query: 203  VNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSV 262
            VN GQ ATFQC A G+    D+LWLQ  + RD  L   +V + RRF A+ +V +T +R  
Sbjct: 196  VNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDA 255

Query: 263  SKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIIL 322
             KYRC+IR++GG G+SNYAEL+VKEPP PIAPP+L +VGATYLWI+ NANSI GDGPI+ 
Sbjct: 256  GKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVA 315

Query: 323  KEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTK 382
            +EVEY T +G+W +   VDS +YK+ HLDPD EYEI VLLTRPGEGGTG PGP L TRTK
Sbjct: 316  REVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTK 375

Query: 383  CADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVI- 441
            CADP+ GP+ +E+V++++RQ+T++WEPFGY VTRCHSYNLTV Y Y    Q+   EEV  
Sbjct: 376  CADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSW 435

Query: 442  -QTSSH--YTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPF 498
               +SH  +T+  L P+  + ++L+L NPEGR ES+EL+VQT+ED+PGAVP ESIQG  F
Sbjct: 436  DTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTF 495

Query: 499  EEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYP 558
            EEKI++QW+ P +T GVITLYEI YKAV S DP  DLS+Q G+V KL NETH LF GLYP
Sbjct: 496  EEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYP 555

Query: 559  GTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRG 618
            GTTYSFTI+ASTAKGFGPP T +  TKISAPSMP Y+ +TPLN+TD T+TVMLKPA SRG
Sbjct: 556  GTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRG 615

Query: 619  APVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQP 678
            APVSVYQ+VV+EER +++++  +I++C+ VP+ ++NAS L+S +YFAAE    +L   QP
Sbjct: 616  APVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQP 675

Query: 679  FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKAPMGSAQVTPGTP 738
            FT+GDNKTYNGYWN PL P KSY IYFQA S+ANGETKI+CV++ATK   G+A   P   
Sbjct: 676  FTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATK---GAATPKP--- 729

Query: 739  LCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSY 798
                            EPEKQ D+TVK+AGVIAG+L+F+II LGV+L +K+R        
Sbjct: 730  --------------VPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKR-------- 767

Query: 799  YLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFS-SSSQDVNGFTDGSRGEL 857
              KLAKK+KET S  ++EM  + ++   +     +  DE FS   + ++NG +  S    
Sbjct: 768  --KLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSF 825

Query: 858  SQPTLT-------------------------------------IQTHPYRTCDPVEMSYP 880
            +  T T                                     +Q+H Y+  +P ++ Y 
Sbjct: 826  TMKTNTLSTSVPNSYYPDPFVPTAILVPINDETHTMASDTSSLVQSHTYKKREPADVPYQ 885

Query: 881  RDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNI 940
              Q  PAIRVADLLQHITQMK  +GYGFKEEYE+  EGQ+A WD+AK+DENR KNRYGNI
Sbjct: 886  TGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNI 945

Query: 941  ISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSA 1000
            I+YDHSRVRL  ++GD +SDYIN NYIDGYHRP HYIATQGPMQET+ DFWRM+W EN+A
Sbjct: 946  IAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTA 1005

Query: 1001 SIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRE 1060
            SI+MVTNLVEVGRVKC +YWPDDTE+Y DIKVTLIETE LAEYVIRTF V+K+G HEIRE
Sbjct: 1006 SIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIRE 1065

Query: 1061 LRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTML 1120
            +R FHFT WPDHGVP +ATGLLGFVRQVK  +PP AGP+VVHCSAGAGRTGCFI ID ML
Sbjct: 1066 IRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIML 1125

Query: 1121 DMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYY 1180
            DMAE EGVVDI+NCVRELR++RVN+VQTEEQYVF+HDAILEACLCG+T++P  + RSLYY
Sbjct: 1126 DMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYY 1185

Query: 1181 NISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFL 1240
            ++++LDPQTNSSQIK+EF+TLN+VTP +R EDCSI LLPRNH+KNR MD+LP DRCLPFL
Sbjct: 1186 DMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFL 1245

Query: 1241 ISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTA 1300
            I++DGESSNYINAALMDS+KQP+AF+VTQHPLPNTV DFWRLV DY+C+SVVMLN++D A
Sbjct: 1246 ITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPA 1305

Query: 1301 QFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWP 1360
            Q C QYWPE     +GPIQVEFVSAD++EDII RIFRI N ARPQDGYR+VQ  Q++GWP
Sbjct: 1306 QLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWP 1365

Query: 1361 AYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQ 1420
             YRDTP SKRS LK++R+++KWQE+Y+G EGRTVVHCLNGGGRSGTFCAI  VCEM++ Q
Sbjct: 1366 MYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQ 1425

Query: 1421 NIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1459
              +DVFH VKTLRNNK NMV+ L+QYKF YEVALEYL+S
Sbjct: 1426 RTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1464


>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
            [Homo sapiens]
          Length = 1440

 Score = 1757 bits (4551), Expect = 0.0
 Identities = 847/1469 (57%), Positives = 1088/1469 (74%), Gaps = 40/1469 (2%)

Query: 1    MASLAALAL----SLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQ 56
            M + AA AL    +LLL    P L  A+ Q +AGGC+FD+    C Y   L  + F W  
Sbjct: 1    MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDL-YDDFEWVH 59

Query: 57   INTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSS 116
            ++  E   L   +P GS+M+V+SS    G+KA L LPT+KENDTHCIDF Y   S+   +
Sbjct: 60   VSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLN 119

Query: 117  PGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGY 176
            PG LN+ V+VN GP  NP+WNV+G     W++AELA+STFWP+ YQVIFE+    G  GY
Sbjct: 120  PGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGY 179

Query: 177  IAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTA 236
            IA+D+++VL++PC K+PHFLRL +VEVN GQNATFQCIA G+ + H+KLWLQ+ NG D  
Sbjct: 180  IAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIP 239

Query: 237  LMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE 296
            +  T+ +NHRRF+A+  + +  +     YRCV +S+ GSGVSN+A+LIV+EPP PIAPP+
Sbjct: 240  VAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQ 299

Query: 297  LLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEY 356
            LL VG TYL I+ NANSIIGDGPIILKEVEYR T+G+W ETH V++P YKLWHLDPD EY
Sbjct: 300  LLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEY 359

Query: 357  EIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTR 416
            EIRVLLTRPGEGGTG PGPPL TRTKCA+P+  P+ ++I +I+AR++ + WE  GY +TR
Sbjct: 360  EIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITR 419

Query: 417  CHSYNLTVQYQYV--FNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE 474
            CH++N+T+ Y Y    N+ + +  ++   +  + +  L P+  + L+++L+NPEGR ESE
Sbjct: 420  CHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESE 479

Query: 475  ELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSAD 534
            E ++QT+EDVPG VP++S+QG  FE KI++ WK P + NG+IT YEI+Y ++ S DP+  
Sbjct: 480  ETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVP 539

Query: 535  LSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEY 594
            ++     V  L N THH+F+ L+PGTTY F I+AST KGFGP     + T ISAP++P+Y
Sbjct: 540  VAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDY 599

Query: 595  D-TDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
            +  D  LNET TTITV+L+PAQ++GAP+S YQ+VV+E    +++R A  +EC+ VPV+Y+
Sbjct: 600  EGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQ 659

Query: 654  NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713
            NA S  + +YFAAEL P NLP   PFTVGDN+TY G+WNPPL+P K Y+IYFQA+S    
Sbjct: 660  NAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEK 719

Query: 714  ETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTV-EPEKQVDNTVKMAGVIAG 772
            ETK  CVR+ATKA                   A+T+    + +P KQ D  VK+AG+ AG
Sbjct: 720  ETKTQCVRIATKA-------------------AATEEPEVIPDPAKQTDRVVKIAGISAG 760

Query: 773  LLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASA-DKPTTKLS 831
            +L+FI++LL V+L +K+           KLAKK+K+     ++EM  + +A D+     S
Sbjct: 761  ILVFILLLLVVILIVKKS----------KLAKKRKDAMGNTRQEMTHMVNAMDRSYADQS 810

Query: 832  ASRNDEGFSSSSQDVNGFTDGSRGE-LSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRV 890
                ++  S +  D + F+        +  +  +   P   C+  E  Y   Q  PAIRV
Sbjct: 811  TLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRV 870

Query: 891  ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRL 950
            ADLLQHI  MK    YGFKEEYE+  EGQ+ASWD AK+D+NR KNRYGNII+YDHSRV L
Sbjct: 871  ADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVIL 930

Query: 951  LVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVE 1010
              ++ DP SDYINANYIDGY RP HYIATQGP+ ETV DFWRMIWQE SA IVMVTNLVE
Sbjct: 931  QPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVE 990

Query: 1011 VGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWP 1070
            VGRVKC +YWPDDTEVYGD KVT +E EPLAEYV+RTFT++++GY+EIRE++ FHFT WP
Sbjct: 991  VGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWP 1050

Query: 1071 DHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVD 1130
            DHGVP +ATGLL F+R+VK  NPP AGPIVVHCSAGAGRTGC+I ID MLDMAE EGVVD
Sbjct: 1051 DHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVD 1110

Query: 1131 IFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTN 1190
            I+NCV+ LR++R+N+VQTEEQY+F+HDAILEACLCG TAIPVCEF++ Y+++ R+D QTN
Sbjct: 1111 IYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTN 1170

Query: 1191 SSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNY 1250
            SS +KDEFQTLN VTPR++ EDCSI  LPRNHDKNR MD+LP DRCLPFLI++DGESSNY
Sbjct: 1171 SSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNY 1230

Query: 1251 INAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEK 1310
            INAALMDS++QPAAF+VTQ+PLPNTV DFWRLV+DY C+S+VMLNE+D +Q C QYWPE+
Sbjct: 1231 INAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEE 1290

Query: 1311 TSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKR 1370
                YGPIQVE +S  +D D+I+RIFRICN+ RPQ+GY +VQ  QY+GW ++R+ P SKR
Sbjct: 1291 GMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKR 1350

Query: 1371 SLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVK 1430
            S LK++ ++EKWQE+ +  EGRT++HCLNGGGRSG FCAI  V EM+++QN++DVFH VK
Sbjct: 1351 SFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVK 1410

Query: 1431 TLRNNKSNMVETLEQYKFVYEVALEYLSS 1459
            TLRN+K NMVE  EQY+F Y+VALEYL S
Sbjct: 1411 TLRNSKPNMVEAPEQYRFCYDVALEYLES 1439


>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
            [Homo sapiens]
          Length = 1446

 Score = 1751 bits (4534), Expect = 0.0
 Identities = 847/1475 (57%), Positives = 1088/1475 (73%), Gaps = 46/1475 (3%)

Query: 1    MASLAALAL----SLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQ 56
            M + AA AL    +LLL    P L  A+ Q +AGGC+FD+    C Y   L  + F W  
Sbjct: 1    MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDL-YDDFEWVH 59

Query: 57   INTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSS 116
            ++  E   L   +P GS+M+V+SS    G+KA L LPT+KENDTHCIDF Y   S+   +
Sbjct: 60   VSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLN 119

Query: 117  PGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGY 176
            PG LN+ V+VN GP  NP+WNV+G     W++AELA+STFWP+ YQVIFE+    G  GY
Sbjct: 120  PGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGY 179

Query: 177  IAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTA 236
            IA+D+++VL++PC K+PHFLRL +VEVN GQNATFQCIA G+ + H+KLWLQ+ NG D  
Sbjct: 180  IAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIP 239

Query: 237  LMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE 296
            +  T+ +NHRRF+A+  + +  +     YRCV +S+ GSGVSN+A+LIV+EPP PIAPP+
Sbjct: 240  VAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQ 299

Query: 297  LLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEY 356
            LL VG TYL I+ NANSIIGDGPIILKEVEYR T+G+W ETH V++P YKLWHLDPD EY
Sbjct: 300  LLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEY 359

Query: 357  EIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTR 416
            EIRVLLTRPGEGGTG PGPPL TRTKCA+P+  P+ ++I +I+AR++ + WE  GY +TR
Sbjct: 360  EIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITR 419

Query: 417  CHSYNLTVQYQYV--FNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE 474
            CH++N+T+ Y Y    N+ + +  ++   +  + +  L P+  + L+++L+NPEGR ESE
Sbjct: 420  CHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESE 479

Query: 475  ELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSAD 534
            E ++QT+EDVPG VP++S+QG  FE KI++ WK P + NG+IT YEI+Y ++ S DP+  
Sbjct: 480  ETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVP 539

Query: 535  LSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEY 594
            ++     V  L N THH+F+ L+PGTTY F I+AST KGFGP     + T ISAP++P+Y
Sbjct: 540  VAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDY 599

Query: 595  D-TDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
            +  D  LNET TTITV+L+PAQ++GAP+S YQ+VV+E    +++R A  +EC+ VPV+Y+
Sbjct: 600  EGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQ 659

Query: 654  NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713
            NA S  + +YFAAEL P NLP   PFTVGDN+TY G+WNPPL+P K Y+IYFQA+S    
Sbjct: 660  NAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEK 719

Query: 714  ETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTV-EPEKQVDNTVKMAGVIAG 772
            ETK  CVR+ATKA                   A+T+    + +P KQ D  VK+AG+ AG
Sbjct: 720  ETKTQCVRIATKA-------------------AATEEPEVIPDPAKQTDRVVKIAGISAG 760

Query: 773  LLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASA-DKPTTKLS 831
            +L+FI++LL V+L +K+           KLAKK+K+     ++EM  + +A D+     S
Sbjct: 761  ILVFILLLLVVILIVKKS----------KLAKKRKDAMGNTRQEMTHMVNAMDRSYADQS 810

Query: 832  ASRNDEGFSSSSQDVNGFTDGSRGE-LSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRV 890
                ++  S +  D + F+        +  +  +   P   C+  E  Y   Q  PAIRV
Sbjct: 811  TLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRV 870

Query: 891  ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRL 950
            ADLLQHI  MK    YGFKEEYE+  EGQ+ASWD AK+D+NR KNRYGNII+YDHSRV L
Sbjct: 871  ADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVIL 930

Query: 951  LVLDGDPHSDYINANYID------GYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVM 1004
              ++ DP SDYINANYID      GY RP HYIATQGP+ ETV DFWRMIWQE SA IVM
Sbjct: 931  QPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVM 990

Query: 1005 VTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLF 1064
            VTNLVEVGRVKC +YWPDDTEVYGD KVT +E EPLAEYV+RTFT++++GY+EIRE++ F
Sbjct: 991  VTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQF 1050

Query: 1065 HFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAE 1124
            HFT WPDHGVP +ATGLL F+R+VK  NPP AGPIVVHCSAGAGRTGC+I ID MLDMAE
Sbjct: 1051 HFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAE 1110

Query: 1125 NEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISR 1184
             EGVVDI+NCV+ LR++R+N+VQTEEQY+F+HDAILEACLCG TAIPVCEF++ Y+++ R
Sbjct: 1111 REGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIR 1170

Query: 1185 LDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVD 1244
            +D QTNSS +KDEFQTLN VTPR++ EDCSI  LPRNHDKNR MD+LP DRCLPFLI++D
Sbjct: 1171 IDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITID 1230

Query: 1245 GESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCM 1304
            GESSNYINAALMDS++QPAAF+VTQ+PLPNTV DFWRLV+DY C+S+VMLNE+D +Q C 
Sbjct: 1231 GESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCP 1290

Query: 1305 QYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRD 1364
            QYWPE+    YGPIQVE +S  +D D+I+RIFRICN+ RPQ+GY +VQ  QY+GW ++R+
Sbjct: 1291 QYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHRE 1350

Query: 1365 TPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIID 1424
             P SKRS LK++ ++EKWQE+ +  EGRT++HCLNGGGRSG FCAI  V EM+++QN++D
Sbjct: 1351 VPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVD 1410

Query: 1425 VFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1459
            VFH VKTLRN+K NMVE  EQY+F Y+VALEYL S
Sbjct: 1411 VFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445


>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
            precursor [Homo sapiens]
          Length = 1446

 Score = 1554 bits (4023), Expect = 0.0
 Identities = 759/1471 (51%), Positives = 1020/1471 (69%), Gaps = 45/1471 (3%)

Query: 1    MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSN---CGYSVALGTNGFTWEQI 57
            MA   AL L+L  +L  P       ++ A GC+F+E       C YS A   + F WEQ+
Sbjct: 1    MARAQALVLALTFQLCAP-----ETETPAAGCTFEEASDPAVPCEYSQAQ-YDDFQWEQV 54

Query: 58   NTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSP 117
                       +P GS++MVN+S  A GQ+AH++  +L ENDTHC+ F Y+  SRD  SP
Sbjct: 55   RIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSP 114

Query: 118  GALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYI 177
            G L VYV+VNGGP G+ VWN++G     W +AELA+STFWP+ YQV+FE++      GY+
Sbjct: 115  GTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYM 174

Query: 178  AVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTAL 237
             +D++ +L++PC KAPHF RL +VEVN GQNA+FQC+A G+ ++ ++  LQ+ +G     
Sbjct: 175  GLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPA 234

Query: 238  MVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPEL 297
               R ++HRRF AT  +A  ++     YRCV ++  G+GVSN+AELIVKEPPTPIAPP+L
Sbjct: 235  AGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQL 294

Query: 298  LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357
            L  G TYL I+ N NSIIGDGPI+ KE+EYR   G WAE H V    YKLWHLDPD EYE
Sbjct: 295  LRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYE 354

Query: 358  IRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRC 417
            I VLLTRPG+GGTG PGPPL +RTKCA+P+  P+ +   +I+ARQLTLQWEP GY VTRC
Sbjct: 355  ISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRC 414

Query: 418  HSYNLTVQYQYVF----NQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMES 473
            H+Y +++ Y Y      NQ   E  +  Q  S YT++ L P+  + +RL+L+NPEGR E 
Sbjct: 415  HTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEG 474

Query: 474  EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSA 533
            +E+  QT+EDVP  +  ES+   P E+ I+++W+ P E NG+IT YEI+Y+++ S DP+ 
Sbjct: 475  KEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAV 534

Query: 534  DLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPE 593
            ++   R  + KLRNET+H+F  L+PGTTY F+++A T KGFG    T I T ISAPS   
Sbjct: 535  NVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDY 594

Query: 594  YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
             D  +PL E++ TITV+L+PAQ RGAP+SVYQ++V+EER ++ RR     +CF VP+++ 
Sbjct: 595  ADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFE 654

Query: 654  NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713
             A +   +HYF AEL  ++LP   PFTVGDN+TY G+WNPPL P K+Y IYFQA S   G
Sbjct: 655  AALARGLVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKG 714

Query: 714  ETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGL 773
            ET++NC+R+A KA                   A  ++   +E  ++ +    + G+ AG 
Sbjct: 715  ETRLNCIRIARKA-------------------ACKESKRPLEVSQRSEEMGLILGICAGG 755

Query: 774  LMFIIILLGVMLTIKRR-RNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSA 832
            L  +I+LLG ++ I R+ R+ Y+YSYY K     K T +  Q +   +++ D+  T  S 
Sbjct: 756  LAVLILLLGAIIVIIRKGRDHYAYSYYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQST 815

Query: 833  SRNDEGFSSSSQDVNGFT---DGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIR 889
             + DE    S  D +G++   D   G +++ +  +   P R C      Y   Q  PA+R
Sbjct: 816  LQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVR 875

Query: 890  VADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVR 949
            VADLLQHI QMK  +GYGFK+EYE+  EG    WD  K+ +    +R   + +YD  RV+
Sbjct: 876  VADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVK 931

Query: 950  LLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLV 1009
            L  + GDP++DYINANYIDGYHR  H+IATQGP  E V DFWRM+WQE+ +SIVM+T LV
Sbjct: 932  LHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLV 991

Query: 1010 EVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSW 1069
            EVGRVKC RYWP+D++ YGDIK+ L++TE LAEYV+RTF ++++GY    E+R FHFT+W
Sbjct: 992  EVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAW 1051

Query: 1070 PDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVV 1129
            P+HGVP +ATGLL F+R+VK   PP+AGPIV+HCSAG GRTGC+I +D MLDMAE EGVV
Sbjct: 1052 PEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVV 1111

Query: 1130 DIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQT 1189
            DI+NCV+ L ++RVN++QTEEQY+F+HDAILEACLCG T IPV EF++ Y  + R+DPQ+
Sbjct: 1112 DIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQS 1171

Query: 1190 NSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSN 1249
            NSSQ+++EFQTLN VTP +  E+CSI LLPRN DKNRSMDVLP DRCLPFLIS DG+S+N
Sbjct: 1172 NSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNN 1231

Query: 1250 YINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM---DTAQFCMQY 1306
            YINAAL DS+ + AAF+VT HPL +T  DFWRLV+DY C+S+VMLN++   ++A  C+QY
Sbjct: 1232 YINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQY 1291

Query: 1307 WPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTP 1366
            WPE     YG ++VEF+S   DED++ R+FR+ N++R Q+G+ +V+H Q++ W AYRDTP
Sbjct: 1292 WPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTP 1351

Query: 1367 PSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVF 1426
             SK++ L ++  ++KWQ   +  +GRT+VHCLNGGGRSGTFCA  +V EMI+  N++DVF
Sbjct: 1352 DSKKAFLHLLAEVDKWQA--ESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVF 1409

Query: 1427 HIVKTLRNNKSNMVETLEQYKFVYEVALEYL 1457
               KTLRN K NMVET++QY F Y+VALEYL
Sbjct: 1410 FAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1440


>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
            precursor [Homo sapiens]
          Length = 1436

 Score = 1537 bits (3979), Expect = 0.0
 Identities = 753/1470 (51%), Positives = 1012/1470 (68%), Gaps = 53/1470 (3%)

Query: 1    MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSN---CGYSVALGTNGFTWEQI 57
            MA   AL L+L  +L  P       ++ A GC+F+E       C YS A   + F WEQ+
Sbjct: 1    MARAQALVLALTFQLCAP-----ETETPAAGCTFEEASDPAVPCEYSQAQ-YDDFQWEQV 54

Query: 58   NTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSP 117
                       +P GS++MVN+S  A GQ+AH++  +L ENDTHC+ F Y+  SRD  SP
Sbjct: 55   RIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSP 114

Query: 118  GALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYI 177
            G L VYV+VNGGP G+ VWN++G     W +AELA+STFWP+ YQV+FE++      GY+
Sbjct: 115  GTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYM 174

Query: 178  AVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTAL 237
             +D++ +L++PC KAPHF RL +VEVN GQNA+FQC+A G+ ++ ++  LQ+ +G     
Sbjct: 175  GLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPA 234

Query: 238  MVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPEL 297
               R ++HRRF AT  +A  ++     YRCV ++  G+GVSN+AELIVKEPPTPIAPP+L
Sbjct: 235  AGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQL 294

Query: 298  LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357
            L  G TYL I+ N NSIIGDGPI+ KE+EYR   G WAE H V    YKLWHLDPD EYE
Sbjct: 295  LRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYE 354

Query: 358  IRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRC 417
            I VLLTRPG+GGTG PGPPL +RTKCA+P+  P+ +   +I+ARQLTLQWEP GY VTRC
Sbjct: 355  ISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRC 414

Query: 418  HSYNLTVQYQYVF----NQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMES 473
            H+Y +++ Y Y      NQ   E  +  Q  S YT++ L P+  + +RL+L+NPEGR E 
Sbjct: 415  HTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEG 474

Query: 474  EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSA 533
            +E+  QT+EDVP  +  ES+   P E+ I+++W+ P E NG+IT YEI+Y+++ S DP+ 
Sbjct: 475  KEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAV 534

Query: 534  DLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPE 593
            ++   R  + KLRNET+H+F  L+PGTTY F+++A T KGFG    T I T ISAPS   
Sbjct: 535  NVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDY 594

Query: 594  YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
             D  +PL E++ TITV+L+PAQ RGAP+SVYQ++V+EER ++ RR     +CF VP+++ 
Sbjct: 595  ADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFE 654

Query: 654  NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713
             A +   +HYF AEL  ++LP   PFTVGDN+TY G+WNPPL P K+Y IYFQA S   G
Sbjct: 655  AALARGLVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKG 714

Query: 714  ETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGL 773
            ET++NC+R+A KA                   A  ++   +E  ++ +    + G+ AG 
Sbjct: 715  ETRLNCIRIARKA-------------------ACKESKRPLEVSQRSEEMGLILGICAGG 755

Query: 774  LMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSAS 833
            L  +I+LLG ++ I R+          K     K T +  Q +   +++ D+  T  S  
Sbjct: 756  LAVLILLLGAIIVIIRKG---------KPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTL 806

Query: 834  RNDEGFSSSSQDVNGFT---DGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRV 890
            + DE    S  D +G++   D   G +++ +  +   P R C      Y   Q  PA+RV
Sbjct: 807  QEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRV 866

Query: 891  ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRL 950
            ADLLQHI QMK  +GYGFK+EYE+  EG    WD  K+ +    +R   + +YD  RV+L
Sbjct: 867  ADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKL 922

Query: 951  LVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVE 1010
              + GDP++DYINANYIDGYHR  H+IATQGP  E V DFWRM+WQE+ +SIVM+T LVE
Sbjct: 923  HPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVE 982

Query: 1011 VGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWP 1070
            VGRVKC RYWP+D++ YGDIK+ L++TE LAEYV+RTF ++++GY    E+R FHFT+WP
Sbjct: 983  VGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWP 1042

Query: 1071 DHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVD 1130
            +HGVP +ATGLL F+R+VK   PP+AGPIV+HCSAG GRTGC+I +D MLDMAE EGVVD
Sbjct: 1043 EHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVD 1102

Query: 1131 IFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTN 1190
            I+NCV+ L ++RVN++QTEEQY+F+HDAILEACLCG T IPV EF++ Y  + R+DPQ+N
Sbjct: 1103 IYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSN 1162

Query: 1191 SSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNY 1250
            SSQ+++EFQTLN VTP +  E+CSI LLPRN DKNRSMDVLP DRCLPFLIS DG+S+NY
Sbjct: 1163 SSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNY 1222

Query: 1251 INAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM---DTAQFCMQYW 1307
            INAAL DS+ + AAF+VT HPL +T  DFWRLV+DY C+S+VMLN++   ++A  C+QYW
Sbjct: 1223 INAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYW 1282

Query: 1308 PEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPP 1367
            PE     YG ++VEF+S   DED++ R+FR+ N++R Q+G+ +V+H Q++ W AYRDTP 
Sbjct: 1283 PEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPD 1342

Query: 1368 SKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFH 1427
            SK++ L ++  ++KWQ   +  +GRT+VHCLNGGGRSGTFCA  +V EMI+  N++DVF 
Sbjct: 1343 SKKAFLHLLAEVDKWQA--ESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFF 1400

Query: 1428 IVKTLRNNKSNMVETLEQYKFVYEVALEYL 1457
              KTLRN K NMVET++QY F Y+VALEYL
Sbjct: 1401 AAKTLRNYKPNMVETMDQYHFCYDVALEYL 1430


>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
            precursor [Homo sapiens]
          Length = 1442

 Score = 1530 bits (3962), Expect = 0.0
 Identities = 753/1476 (51%), Positives = 1012/1476 (68%), Gaps = 59/1476 (3%)

Query: 1    MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSN---CGYSVALGTNGFTWEQI 57
            MA   AL L+L  +L  P       ++ A GC+F+E       C YS A   + F WEQ+
Sbjct: 1    MARAQALVLALTFQLCAP-----ETETPAAGCTFEEASDPAVPCEYSQAQ-YDDFQWEQV 54

Query: 58   NTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSP 117
                       +P GS++MVN+S  A GQ+AH++  +L ENDTHC+ F Y+  SRD  SP
Sbjct: 55   RIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSP 114

Query: 118  GALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYI 177
            G L VYV+VNGGP G+ VWN++G     W +AELA+STFWP+ YQV+FE++      GY+
Sbjct: 115  GTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYM 174

Query: 178  AVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTAL 237
             +D++ +L++PC KAPHF RL +VEVN GQNA+FQC+A G+ ++ ++  LQ+ +G     
Sbjct: 175  GLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPA 234

Query: 238  MVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPEL 297
               R ++HRRF AT  +A  ++     YRCV ++  G+GVSN+AELIVKEPPTPIAPP+L
Sbjct: 235  AGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQL 294

Query: 298  LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357
            L  G TYL I+ N NSIIGDGPI+ KE+EYR   G WAE H V    YKLWHLDPD EYE
Sbjct: 295  LRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYE 354

Query: 358  IRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRC 417
            I VLLTRPG+GGTG PGPPL +RTKCA+P+  P+ +   +I+ARQLTLQWEP GY VTRC
Sbjct: 355  ISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRC 414

Query: 418  HSYNLTVQYQYVF----NQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMES 473
            H+Y +++ Y Y      NQ   E  +  Q  S YT++ L P+  + +RL+L+NPEGR E 
Sbjct: 415  HTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEG 474

Query: 474  EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSA 533
            +E+  QT+EDVP  +  ES+   P E+ I+++W+ P E NG+IT YEI+Y+++ S DP+ 
Sbjct: 475  KEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAV 534

Query: 534  DLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPE 593
            ++   R  + KLRNET+H+F  L+PGTTY F+++A T KGFG    T I T ISAPS   
Sbjct: 535  NVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDY 594

Query: 594  YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
             D  +PL E++ TITV+L+PAQ RGAP+SVYQ++V+EER ++ RR     +CF VP+++ 
Sbjct: 595  ADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFE 654

Query: 654  NASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANG 713
             A +   +HYF AEL  ++LP   PFTVGDN+TY G+WNPPL P K+Y IYFQA S   G
Sbjct: 655  AALARGLVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKG 714

Query: 714  ETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGL 773
            ET++NC+R+A KA                   A  ++   +E  ++ +    + G+ AG 
Sbjct: 715  ETRLNCIRIARKA-------------------ACKESKRPLEVSQRSEEMGLILGICAGG 755

Query: 774  LMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSAS 833
            L  +I+LLG ++ I R+          K     K T +  Q +   +++ D+  T  S  
Sbjct: 756  LAVLILLLGAIIVIIRKG---------KPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTL 806

Query: 834  RNDEGFSSSSQDVNGFT---DGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRV 890
            + DE    S  D +G++   D   G +++ +  +   P R C      Y   Q  PA+RV
Sbjct: 807  QEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRV 866

Query: 891  ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRL 950
            ADLLQHI QMK  +GYGFK+EYE+  EG    WD  K+ +    +R   + +YD  RV+L
Sbjct: 867  ADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKL 922

Query: 951  LVLDGDPHSDYINANYID------GYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVM 1004
              + GDP++DYINANYID      GYHR  H+IATQGP  E V DFWRM+WQE+ +SIVM
Sbjct: 923  HPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVM 982

Query: 1005 VTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLF 1064
            +T LVEVGRVKC RYWP+D++ YGDIK+ L++TE LAEYV+RTF ++++GY    E+R F
Sbjct: 983  ITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQF 1042

Query: 1065 HFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAE 1124
            HFT+WP+HGVP +ATGLL F+R+VK   PP+AGPIV+HCSAG GRTGC+I +D MLDMAE
Sbjct: 1043 HFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAE 1102

Query: 1125 NEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISR 1184
             EGVVDI+NCV+ L ++RVN++QTEEQY+F+HDAILEACLCG T IPV EF++ Y  + R
Sbjct: 1103 CEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIR 1162

Query: 1185 LDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVD 1244
            +DPQ+NSSQ+++EFQTLN VTP +  E+CSI LLPRN DKNRSMDVLP DRCLPFLIS D
Sbjct: 1163 IDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTD 1222

Query: 1245 GESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM---DTAQ 1301
            G+S+NYINAAL DS+ + AAF+VT HPL +T  DFWRLV+DY C+S+VMLN++   ++A 
Sbjct: 1223 GDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAW 1282

Query: 1302 FCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPA 1361
             C+QYWPE     YG ++VEF+S   DED++ R+FR+ N++R Q+G+ +V+H Q++ W A
Sbjct: 1283 PCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSA 1342

Query: 1362 YRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQN 1421
            YRDTP SK++ L ++  ++KWQ   +  +GRT+VHCLNGGGRSGTFCA  +V EMI+  N
Sbjct: 1343 YRDTPDSKKAFLHLLAEVDKWQA--ESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHN 1400

Query: 1422 IIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL 1457
            ++DVF   KTLRN K NMVET++QY F Y+VALEYL
Sbjct: 1401 LVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1436


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
            precursor [Homo sapiens]
          Length = 1501

 Score =  504 bits (1299), Expect = e-142
 Identities = 385/1255 (30%), Positives = 583/1255 (46%), Gaps = 184/1255 (14%)

Query: 253  SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306
            SVA  +  S  ++R V  ++ G G  +   L       P + P       L +      W
Sbjct: 379  SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438

Query: 307  IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366
             +P   +    G  +   ++       W + ++ DS    + +L P   Y ++VL     
Sbjct: 439  KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 496

Query: 367  EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
              G GP    +   T+   P   P N +        + L W P           +    Y
Sbjct: 497  SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 547

Query: 427  QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDV 484
            + V+   ++  E+   I+  + Y L+GL+P      RL   +P+G   S   +       
Sbjct: 548  ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI------- 600

Query: 485  PGAVPLESIQGGPFEEK------IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADL 535
              A  ++S+    F  K      + + W+ P   N  +  ++I Y   K V  +D  A  
Sbjct: 601  -SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA-- 656

Query: 536  SSQRGKVFKLRNETHHLFVGLYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPE 593
                         T  L V L P  +YSF +  + ++A G    VT + A  +   + P 
Sbjct: 657  -------------TQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPA 702

Query: 594  YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
            +   T L   D  ITV L    +       Y ++V    L+KSR        F  P    
Sbjct: 703  FIGKTNL---DGMITVQLPEVPANENIKGYYIIIVP---LKKSRGK------FIKPWESP 750

Query: 654  NASSLDSL------------HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSP 697
            +   LD L            +    ELKP   A+  V    FT+GD+K Y G+ N  L  
Sbjct: 751  DEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQS 810

Query: 698  LKSYSIYFQALSKANGETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPE 757
             + Y ++F      + E+K+        +P     V                 S  ++P+
Sbjct: 811  GQEY-VFFVLAVMEHAESKMYAT-----SPYSDPVV-----------------SMDLDPQ 847

Query: 758  KQVDNTVKMAGVIAGLL--MFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQR 815
               D    +  V+  +L  +FII ++  +L  KR+R                        
Sbjct: 848  PITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKR------------------------ 883

Query: 816  EMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPV 875
                   A+  + K S   N E                          I +H     DPV
Sbjct: 884  -------AESDSRKSSIPNNKE--------------------------IPSH--HPTDPV 908

Query: 876  EM-----SYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDE 930
            E+       P     P I + +L  HI ++K      F +EYE++  GQ  +W+ +  + 
Sbjct: 909  ELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEV 968

Query: 931  NRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDF 990
            N+ KNRY N+I+YDHSRV L  ++G P SDY+NANYIDGY +   YIATQG + ET  DF
Sbjct: 969  NKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDF 1028

Query: 991  WRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFT 1049
            WRMIW++ SA++VM+T L E  RVKC +YWP   TE +G ++VTL++T  LA Y +RTF 
Sbjct: 1029 WRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFA 1088

Query: 1050 VQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGR 1109
            + K G  E RE+R F FT+WPDHGVP + T  L F+R+VK  NPP+AGP+VVHCSAG GR
Sbjct: 1089 LYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGR 1148

Query: 1110 TGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTA 1169
            TGCFI ID ML+  ++E  VDI+  V  +RAQR  +VQTE+QY+F+HDA+LEA  CGNT 
Sbjct: 1149 TGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTE 1208

Query: 1170 IPVCEFRSLYYNISRLDP-QTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSM 1228
            +P    R+LY  I +L   +T  +    E +   + + +          LP N  KNR +
Sbjct: 1209 VPA---RNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLV 1265

Query: 1229 DVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYN 1287
            +++P +     L  + G E S+YINA+ +D ++Q  A++ TQ PL  T  DFWR+++++N
Sbjct: 1266 NIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHN 1325

Query: 1288 CSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQ 1345
             + VVML ++     + C QYWP + S  Y    V+ ++       I R F++ +    Q
Sbjct: 1326 STIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQ 1385

Query: 1346 DGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSG 1405
               R V+  Q+  WP  +  P S    +  + ++ K +EQ+ G++G   VHC  G GR+G
Sbjct: 1386 S--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTG 1441

Query: 1406 TFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1460
             F  +  V E ++ + ++D+F  VK LR  +  MV+T +QY+F Y  ALEYL SF
Sbjct: 1442 VFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1496



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 82/325 (25%), Positives = 133/325 (40%), Gaps = 34/325 (10%)

Query: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316
           R  + Y CV  S  G  +   A++ VK  P P   P   E  A   T  W   N   +  
Sbjct: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 351

Query: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
                + + + + +   + E   V +  Y +  L P  +YE RV+       G GPP  P
Sbjct: 352 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 407

Query: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432
           + T+T    P   P++V+   + +  + +QW    EP G  +     Y      Q+V N 
Sbjct: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 466

Query: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490
            ++     +  S   T+  L P  T  +++L   S  +G + S+  V+ T+  VPG  PL
Sbjct: 467 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 520

Query: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550
                   E  I + W PP   +  I  YE+ YK  G       ++ + G  ++L+    
Sbjct: 521 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 573

Query: 551 HLFVGLYPGTTYSFTIKASTAKGFG 575
               GL P + Y F + A + +G G
Sbjct: 574 ----GLKPNSLYYFRLAARSPQGLG 594


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score =  504 bits (1298), Expect = e-142
 Identities = 356/1107 (32%), Positives = 546/1107 (49%), Gaps = 159/1107 (14%)

Query: 390  PQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTL 449
            PQN+ +  +      L W+P   A       + TV ++ + +QQ+ +    I T + +TL
Sbjct: 919  PQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQN---ITTDTRFTL 975

Query: 450  RGLRPFMT--IRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPF------EEK 501
             GL+P  T  I++R   S   G +      +Q+       +P+E +    F      +  
Sbjct: 976  TGLKPDTTYDIKVRAWTSKGSGPLSPS---IQSR-----TMPVEQVFAKNFRVAAAMKTS 1027

Query: 502  IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561
            + + W+ P+     +  ++I Y          D  S R            L   L P T 
Sbjct: 1028 VLLSWEVPDSYKSAVP-FKILYNGQSV---EVDGHSMR-----------KLIADLQPNTE 1072

Query: 562  YSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGA 619
            YSF +  + S+A G    V+ R A  +    +P           D    + +   Q    
Sbjct: 1073 YSFVLMNRGSSAGGLQHLVSIRTAPDL----LPHKPLPASAYIEDGRFDLSMPHVQDPSL 1128

Query: 620  PVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAE----------LK 669
                Y +VV  +R+  S     +   +S P        L+++     E          LK
Sbjct: 1129 VRWFYIVVVPIDRVGGSM----LTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLK 1184

Query: 670  P---ANLPVT-QPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATK 725
            P   A L V  + FT+GD K Y G++N PLSP  SY  +  A  K   + K    R A+ 
Sbjct: 1185 PYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RYAS- 1239

Query: 726  APMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVML 785
            +P     V   TP       A  Q     EPE      + + G +  +++ I+I++ ++L
Sbjct: 1240 SPYSDEIVVQVTP-------AQQQE----EPEM-----LWVTGPVLAVILIILIVIAILL 1283

Query: 786  TIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQD 845
                               K+K T S + ++   +   D                     
Sbjct: 1284 F------------------KRKRTHSPSSKDEQSIGLKD--------------------- 1304

Query: 846  VNGFTDGSRGELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRVADLLQHITQM 900
                             ++  H   + DPVEM       P  +  P I + DL  +I ++
Sbjct: 1305 -----------------SLLAH---SSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERL 1344

Query: 901  KRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSD 960
            K   G  F +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  +DG P SD
Sbjct: 1345 KANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSD 1404

Query: 961  YINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYW 1020
            YINANYIDGY +   YIATQGP+ ET+ DFWRM+W++ +A++VM+T L E  RVKC +YW
Sbjct: 1405 YINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYW 1464

Query: 1021 PD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYAT 1079
            P   TE  G I+VTL++T  LA Y +RTF + K G  E RELR F F +WPDHGVP Y T
Sbjct: 1465 PARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPT 1524

Query: 1080 GLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELR 1139
             +L F+R+VK  NP +AGP+VVHCSAG GRTGCFI ID ML+  ++E  VDI+  V  +R
Sbjct: 1525 PILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMR 1584

Query: 1140 AQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRL---DPQTNSSQIKD 1196
            +QR  +VQTE+QYVF+H+A+LEA  CG+T +P    R+LY +I +L    P  + + ++ 
Sbjct: 1585 SQRNYMVQTEDQYVFIHEALLEAATCGHTEVPA---RNLYAHIQKLGQVPPGESVTAMEL 1641

Query: 1197 EFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAAL 1255
            EF+ L   + +          LP N  KNR ++++P +     L  + G E S+YINA+ 
Sbjct: 1642 EFKLL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASF 1699

Query: 1256 MDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSG 1313
            +D ++Q  A++ TQ PL  +  DFWR+++++N + +VML ++     + C QYWP + S 
Sbjct: 1700 LDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA 1759

Query: 1314 CYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLL 1373
             Y    V+ ++       I R F++ +    Q   R ++  Q+  WP  +  P +    +
Sbjct: 1760 RYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFI 1816

Query: 1374 KVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLR 1433
              + ++ K +EQ+ G++G   VHC  G GR+G F  +  V E ++ + ++D+F  VKTLR
Sbjct: 1817 DFIGQVHKTKEQF-GQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLR 1875

Query: 1434 NNKSNMVETLEQYKFVYEVALEYLSSF 1460
              +  MV+T +QY+  Y  ALEYL SF
Sbjct: 1876 TQRPAMVQTEDQYQLCYRAALEYLGSF 1902



 Score = 80.9 bits (198), Expect = 8e-15
 Identities = 100/413 (24%), Positives = 161/413 (38%), Gaps = 40/413 (9%)

Query: 249 SATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE---LLAVGATYL 305
           +++ ++ D    ++ +++   RSD G GV            TP APP+    +++G+T +
Sbjct: 564 TSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTV 623

Query: 306 ---WIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVD--SPNYKLWHLDPDVEY-EIR 359
              W+ P A+S   +G I    V Y    G     H+VD  S  +  W L    ++ E R
Sbjct: 624 RVSWVPPPADS--RNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYR 681

Query: 360 VLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----------EP 409
           V +    + G GP   P+  RT    P   P+ VE+  + +  + + W          + 
Sbjct: 682 VWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQI 741

Query: 410 FGYAVTRCHSYN-----LTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLL 464
            GY VT     N     L +    +  + Q+  EE        T+ GL P  T  + +  
Sbjct: 742 RGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEE--SEDYETTISGLTPETTYSVTVAA 799

Query: 465 SNPEG-RMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINY 523
              +G    S+  +V T   VPG  P   I        + +QW PP E  G +  Y + Y
Sbjct: 800 YTTKGDGARSKPKIVTTTGAVPGR-PTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQY 857

Query: 524 KAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIA 583
                  P+   +   GK     ++ H    GL+ GTTY F + A    G G      I 
Sbjct: 858 CRADEARPN---TIDFGK-----DDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIR 909

Query: 584 TKISAPS-MPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQK 635
           T    PS  P+    T L  + T +         R   +  Y +V ++   Q+
Sbjct: 910 TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQ 962



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 106/454 (23%), Positives = 173/454 (38%), Gaps = 82/454 (18%)

Query: 203 VNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSV 262
           V   + AT  C AGG     +  W + +   D A    R+   R  S  + +  + +   
Sbjct: 146 VEKARTATMLCAAGGN-PDPEISWFKDFLPVDPATSNGRIKQLR--SGALQIESSEESDQ 202

Query: 263 SKYRCVIRSDGGSGVSNYAELIVKE---PPTPIAPPE-------------LLAVGATYLW 306
            KY CV  +  G+  S  A L V+     P    PP               +AVGA   +
Sbjct: 203 GKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPY 262

Query: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNY------KLWHLDPDVEYEIRV 360
           +K    +       + KE E          +++V S NY       L  ++   +  ++ 
Sbjct: 263 VKWMMGA-----EELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKA 317

Query: 361 LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY 420
           L           P PP+              ++ + +  A  +TL W+         +  
Sbjct: 318 L-----------PKPPI--------------DLVVTETTATSVTLTWDSGNSEPVTYYG- 351

Query: 421 NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELV-VQ 479
              +QY+    +  ++  + + T+  Y++ GL PF     R+L  N  GR    E V  +
Sbjct: 352 ---IQYRAAGTEGPFQEVDGVATT-RYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRAR 407

Query: 480 TEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQR 539
           T E  P + P            + +QW+PP E NG++  Y + Y       P+A      
Sbjct: 408 TGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNA------ 461

Query: 540 GKVFKLRNETHHLFV---GLYPGTTYSFTIKASTAKGFGPP-VTTRIATKISAPSMP-EY 594
              +   N    L      L PG TYS  + A TA G GPP  T ++ T+   P+ P ++
Sbjct: 462 ---WHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADF 518

Query: 595 DTDTPLNETDTTITV-MLKPAQSRGAPVSVYQLV 627
             +    E+DT I +  L P Q R   + +Y+LV
Sbjct: 519 QAEV---ESDTRIQLSWLLPPQER---IIMYELV 546



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 96/377 (25%), Positives = 147/377 (38%), Gaps = 39/377 (10%)

Query: 263 SKYRCVIRSDGGSGVSNYAELIVK---EPPTPIAPPELLAVGATYLWIKPNANSIIGDGP 319
           + Y CV  S  G  +   A++ VK   +PP  +   E  A   T  W   N+       P
Sbjct: 294 ANYTCVAISSLGM-IEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSE------P 346

Query: 320 IILKEVEYRT--TTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPL 377
           +    ++YR   T G + E   V +  Y +  L P  EY  RVL       G GPP   +
Sbjct: 347 VTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN--SIGRGPPSEAV 404

Query: 378 TTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEA 437
             RT    P   P+ V+   + A  + +QWEP          Y +   Y    +++   A
Sbjct: 405 RARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV---YYTPDSRRPPNA 461

Query: 438 EEVIQTSSHY--TLRGLRPFMTIRLRLLLSNPEG-RMESEELVVQTEEDVPGAVPLESIQ 494
                T +    T+  L P +T  LR+L     G    S  + V+T++ VP A P +   
Sbjct: 462 WHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQPADFQA 520

Query: 495 GGPFEEKIYIQW-KPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLF 553
               + +I + W  PP E    I +YE+ Y A    D    ++      + L +      
Sbjct: 521 EVESDTRIQLSWLLPPQER---IIMYELVYWAAEDEDQQHKVTFDPTSSYTLED------ 571

Query: 554 VGLYPGTTYSFTIKASTAKGFG---PPVTTRIATKISAPSMPEYDT-DTPLNETDTTITV 609
             L P T Y F + A +  G G   P +  R A   S PS P        +  T   ++ 
Sbjct: 572 --LKPDTLYRFQLAARSDMGVGVFTPTIEARTAQ--STPSAPPQKVMCVSMGSTTVRVSW 627

Query: 610 MLKPAQSRGAPVSVYQL 626
           +  PA SR   ++ Y +
Sbjct: 628 VPPPADSRNGVITQYSV 644



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 74/296 (25%), Positives = 113/296 (38%), Gaps = 52/296 (17%)

Query: 308  KPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLL-TRPG 366
            +P    II D  ++L E ++R       ET I          L P+  Y + V   T  G
Sbjct: 755  EPRGLPIIQD--VMLAEAQWRPEESEDYETTISG--------LTPETTYSVTVAAYTTKG 804

Query: 367  EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEP--------FGYAVTRCH 418
            +G    P    TT       V G   + I         LQW P         GY +  C 
Sbjct: 805  DGARSKPKIVTTTGA-----VPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCR 859

Query: 419  SYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVV 478
            +           ++ +    +  +   H+T+ GL    T   RL   N  G  E  E  +
Sbjct: 860  A-----------DEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEI 908

Query: 479  QTEEDVPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLDPSADLS 536
            +T ED+P   P      G       + W PP   E NG I  Y + ++         D++
Sbjct: 909  RTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR---------DIN 959

Query: 537  SQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMP 592
            SQ+ ++  +  +T     GL P TTY   ++A T+KG GP     ++  I + +MP
Sbjct: 960  SQQ-ELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGP-----LSPSIQSRTMP 1009


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score =  504 bits (1298), Expect = e-142
 Identities = 356/1107 (32%), Positives = 546/1107 (49%), Gaps = 159/1107 (14%)

Query: 390  PQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTL 449
            PQN+ +  +      L W+P   A       + TV ++ + +QQ+ +    I T + +TL
Sbjct: 910  PQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQN---ITTDTRFTL 966

Query: 450  RGLRPFMT--IRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPF------EEK 501
             GL+P  T  I++R   S   G +      +Q+       +P+E +    F      +  
Sbjct: 967  TGLKPDTTYDIKVRAWTSKGSGPLSPS---IQSR-----TMPVEQVFAKNFRVAAAMKTS 1018

Query: 502  IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561
            + + W+ P+     +  ++I Y          D  S R            L   L P T 
Sbjct: 1019 VLLSWEVPDSYKSAVP-FKILYNGQSV---EVDGHSMR-----------KLIADLQPNTE 1063

Query: 562  YSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGA 619
            YSF +  + S+A G    V+ R A  +    +P           D    + +   Q    
Sbjct: 1064 YSFVLMNRGSSAGGLQHLVSIRTAPDL----LPHKPLPASAYIEDGRFDLSMPHVQDPSL 1119

Query: 620  PVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAE----------LK 669
                Y +VV  +R+  S     +   +S P        L+++     E          LK
Sbjct: 1120 VRWFYIVVVPIDRVGGSM----LTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLK 1175

Query: 670  P---ANLPVT-QPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATK 725
            P   A L V  + FT+GD K Y G++N PLSP  SY  +  A  K   + K    R A+ 
Sbjct: 1176 PYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQK----RYAS- 1230

Query: 726  APMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVML 785
            +P     V   TP       A  Q     EPE      + + G +  +++ I+I++ ++L
Sbjct: 1231 SPYSDEIVVQVTP-------AQQQE----EPEM-----LWVTGPVLAVILIILIVIAILL 1274

Query: 786  TIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQD 845
                               K+K T S + ++   +   D                     
Sbjct: 1275 F------------------KRKRTHSPSSKDEQSIGLKD--------------------- 1295

Query: 846  VNGFTDGSRGELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRVADLLQHITQM 900
                             ++  H   + DPVEM       P  +  P I + DL  +I ++
Sbjct: 1296 -----------------SLLAH---SSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERL 1335

Query: 901  KRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSD 960
            K   G  F +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  +DG P SD
Sbjct: 1336 KANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSD 1395

Query: 961  YINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYW 1020
            YINANYIDGY +   YIATQGP+ ET+ DFWRM+W++ +A++VM+T L E  RVKC +YW
Sbjct: 1396 YINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYW 1455

Query: 1021 PD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYAT 1079
            P   TE  G I+VTL++T  LA Y +RTF + K G  E RELR F F +WPDHGVP Y T
Sbjct: 1456 PARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPT 1515

Query: 1080 GLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELR 1139
             +L F+R+VK  NP +AGP+VVHCSAG GRTGCFI ID ML+  ++E  VDI+  V  +R
Sbjct: 1516 PILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMR 1575

Query: 1140 AQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRL---DPQTNSSQIKD 1196
            +QR  +VQTE+QYVF+H+A+LEA  CG+T +P    R+LY +I +L    P  + + ++ 
Sbjct: 1576 SQRNYMVQTEDQYVFIHEALLEAATCGHTEVPA---RNLYAHIQKLGQVPPGESVTAMEL 1632

Query: 1197 EFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAAL 1255
            EF+ L   + +          LP N  KNR ++++P +     L  + G E S+YINA+ 
Sbjct: 1633 EFKLL--ASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASF 1690

Query: 1256 MDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSG 1313
            +D ++Q  A++ TQ PL  +  DFWR+++++N + +VML ++     + C QYWP + S 
Sbjct: 1691 LDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA 1750

Query: 1314 CYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLL 1373
             Y    V+ ++       I R F++ +    Q   R ++  Q+  WP  +  P +    +
Sbjct: 1751 RYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTIRQFQFTDWPE-QGVPKTGEGFI 1807

Query: 1374 KVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLR 1433
              + ++ K +EQ+ G++G   VHC  G GR+G F  +  V E ++ + ++D+F  VKTLR
Sbjct: 1808 DFIGQVHKTKEQF-GQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLR 1866

Query: 1434 NNKSNMVETLEQYKFVYEVALEYLSSF 1460
              +  MV+T +QY+  Y  ALEYL SF
Sbjct: 1867 TQRPAMVQTEDQYQLCYRAALEYLGSF 1893



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 106/454 (23%), Positives = 173/454 (38%), Gaps = 82/454 (18%)

Query: 203 VNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSV 262
           V   + AT  C AGG     +  W + +   D A    R+   R  S  + +  + +   
Sbjct: 146 VEKARTATMLCAAGGN-PDPEISWFKDFLPVDPATSNGRIKQLR--SGALQIESSEESDQ 202

Query: 263 SKYRCVIRSDGGSGVSNYAELIVKE---PPTPIAPPE-------------LLAVGATYLW 306
            KY CV  +  G+  S  A L V+     P    PP               +AVGA   +
Sbjct: 203 GKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPY 262

Query: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNY------KLWHLDPDVEYEIRV 360
           +K    +       + KE E          +++V S NY       L  ++   +  ++ 
Sbjct: 263 VKWMMGA-----EELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKA 317

Query: 361 LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY 420
           L           P PP+              ++ + +  A  +TL W+         +  
Sbjct: 318 L-----------PKPPI--------------DLVVTETTATSVTLTWDSGNSEPVTYYG- 351

Query: 421 NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELV-VQ 479
              +QY+    +  ++  + + T+  Y++ GL PF     R+L  N  GR    E V  +
Sbjct: 352 ---IQYRAAGTEGPFQEVDGVATT-RYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRAR 407

Query: 480 TEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQR 539
           T E  P + P            + +QW+PP E NG++  Y + Y       P+A      
Sbjct: 408 TGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNA------ 461

Query: 540 GKVFKLRNETHHLFV---GLYPGTTYSFTIKASTAKGFGPP-VTTRIATKISAPSMP-EY 594
              +   N    L      L PG TYS  + A TA G GPP  T ++ T+   P+ P ++
Sbjct: 462 ---WHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADF 518

Query: 595 DTDTPLNETDTTITV-MLKPAQSRGAPVSVYQLV 627
             +    E+DT I +  L P Q R   + +Y+LV
Sbjct: 519 QAEV---ESDTRIQLSWLLPPQER---IIMYELV 546



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 96/377 (25%), Positives = 147/377 (38%), Gaps = 39/377 (10%)

Query: 263 SKYRCVIRSDGGSGVSNYAELIVK---EPPTPIAPPELLAVGATYLWIKPNANSIIGDGP 319
           + Y CV  S  G  +   A++ VK   +PP  +   E  A   T  W   N+       P
Sbjct: 294 ANYTCVAISSLGM-IEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSE------P 346

Query: 320 IILKEVEYRT--TTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPL 377
           +    ++YR   T G + E   V +  Y +  L P  EY  RVL       G GPP   +
Sbjct: 347 VTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVN--SIGRGPPSEAV 404

Query: 378 TTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEA 437
             RT    P   P+ V+   + A  + +QWEP          Y +   Y    +++   A
Sbjct: 405 RARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV---YYTPDSRRPPNA 461

Query: 438 EEVIQTSSHY--TLRGLRPFMTIRLRLLLSNPEG-RMESEELVVQTEEDVPGAVPLESIQ 494
                T +    T+  L P +T  LR+L     G    S  + V+T++ VP A P +   
Sbjct: 462 WHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVP-AQPADFQA 520

Query: 495 GGPFEEKIYIQW-KPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLF 553
               + +I + W  PP E    I +YE+ Y A    D    ++      + L +      
Sbjct: 521 EVESDTRIQLSWLLPPQER---IIMYELVYWAAEDEDQQHKVTFDPTSSYTLED------ 571

Query: 554 VGLYPGTTYSFTIKASTAKGFG---PPVTTRIATKISAPSMPEYDT-DTPLNETDTTITV 609
             L P T Y F + A +  G G   P +  R A   S PS P        +  T   ++ 
Sbjct: 572 --LKPDTLYRFQLAARSDMGVGVFTPTIEARTAQ--STPSAPPQKVMCVSMGSTTVRVSW 627

Query: 610 MLKPAQSRGAPVSVYQL 626
           +  PA SR   ++ Y +
Sbjct: 628 VPPPADSRNGVITQYSV 644



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 64/254 (25%), Positives = 98/254 (38%), Gaps = 42/254 (16%)

Query: 350  LDPDVEYEIRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWE 408
            L P+  Y + V   T  G+G    P    TT       V G   + I         LQW 
Sbjct: 778  LTPETTYSVTVAAYTTKGDGARSKPKIVTTTGA-----VPGRPTMMISTTAMNTALLQWH 832

Query: 409  P--------FGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRL 460
            P         GY +  C +           ++ +    +  +   H+T+ GL    T   
Sbjct: 833  PPKELPGELLGYRLQYCRA-----------DEARPNTIDFGKDDQHFTVTGLHKGTTYIF 881

Query: 461  RLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITL 518
            RL   N  G  E  E  ++T ED+P   P      G       + W PP   E NG I  
Sbjct: 882  RLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIIS 941

Query: 519  YEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPV 578
            Y + ++         D++SQ+ ++  +  +T     GL P TTY   ++A T+KG GP  
Sbjct: 942  YTVVFR---------DINSQQ-ELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGP-- 989

Query: 579  TTRIATKISAPSMP 592
               ++  I + +MP
Sbjct: 990  ---LSPSIQSRTMP 1000



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 72/282 (25%), Positives = 118/282 (41%), Gaps = 15/282 (5%)

Query: 320 IILKEVEYRTTTGTWAETHIVDSP--NYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPL 377
           II+ E+ Y        +  +   P  +Y L  L PD  Y  R  L    + G G   P +
Sbjct: 540 IIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLY--RFQLAARSDMGVGVFTPTI 597

Query: 378 TTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQ--Y 435
             RT  + P   PQ V  V + +  + + W P             +V Y+ V  + +  +
Sbjct: 598 EARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRH 657

Query: 436 EAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGR-MESEELVVQTEEDVPGAVPLESIQ 494
             + + +  S + L GL  +   R+ +      G   ES  ++V+T+EDVP   P   ++
Sbjct: 658 VVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPP-RKVE 716

Query: 495 GGPFEEK-IYIQWK--PPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHH 551
             P     +++ WK   P++ +G I  Y++ Y  + + +P      Q   + + +  T  
Sbjct: 717 VEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETT-- 774

Query: 552 LFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISA-PSMP 592
              GL P TTYS T+ A T KG G     +I T   A P  P
Sbjct: 775 -ISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRP 815



 Score = 36.2 bits (82), Expect = 0.24
 Identities = 30/122 (24%), Positives = 48/122 (39%), Gaps = 10/122 (8%)

Query: 317  DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
            +G II   V +R         +I     + L  L PD  Y+I+V        G+GP  P 
Sbjct: 936  NGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWT--SKGSGPLSPS 993

Query: 377  LTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYE 436
            + +RT   + V   +N  +       + L WE          SY   V ++ ++N Q  E
Sbjct: 994  IQSRTMPVEQVFA-KNFRVAAAMKTSVLLSWEV-------PDSYKSAVPFKILYNGQSVE 1045

Query: 437  AE 438
             +
Sbjct: 1046 VD 1047


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
            precursor [Homo sapiens]
          Length = 1502

 Score =  501 bits (1291), Expect = e-141
 Identities = 383/1256 (30%), Positives = 584/1256 (46%), Gaps = 182/1256 (14%)

Query: 253  SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306
            SVA  +  S  ++R V  ++ G G  +   L       P + P       L +      W
Sbjct: 376  SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 435

Query: 307  IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366
             +P   +    G  +   ++       W + ++ DS    + +L P   Y ++VL     
Sbjct: 436  KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 493

Query: 367  EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
              G GP    +   T+   P   P N +        + L W P           +    Y
Sbjct: 494  SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 544

Query: 427  QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDV 484
            + V+   ++  E+   I+  + Y L+GL+P      RL   +P+G   S   +       
Sbjct: 545  ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI------- 597

Query: 485  PGAVPLESIQGGPFEEK------IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADL 535
              A  ++S+    F  K      + + W+ P   N  +  ++I Y   K V  +D  A  
Sbjct: 598  -SARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA-- 653

Query: 536  SSQRGKVFKLRNETHHLFVGLYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPE 593
                         T  L V L P  +YSF +  + ++A G    VT + A  +   + P 
Sbjct: 654  -------------TQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPA 699

Query: 594  YDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYR 653
            +   T L   D  ITV L    +       Y ++V    L+KSR        F  P    
Sbjct: 700  FIGKTNL---DGMITVQLPEVPANENIKGYYIIIVP---LKKSRGK------FIKPWESP 747

Query: 654  NASSLDSL------------HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSP 697
            +   LD L            +    ELKP   A+  V    FT+GD+K Y G+ N  L  
Sbjct: 748  DEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQS 807

Query: 698  LKSYSIYFQALSKANGETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPE 757
             + Y ++F      + E+     ++   +P     V                 S  ++P+
Sbjct: 808  GQEY-VFFVLAVMEHAES-----KMYATSPYSDPVV-----------------SMDLDPQ 844

Query: 758  KQVDNT---VKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQ 814
               D     + + G +  ++  I I++ ++L            Y  K  +K+ E+ S   
Sbjct: 845  PITDEEEGLIWVVGPVLAVVFIICIVIAILL------------YKSKPDRKRAESDS--- 889

Query: 815  REMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDP 874
                          K S   N E                          I +H     DP
Sbjct: 890  -------------RKSSIPNNKE--------------------------IPSH--HPTDP 908

Query: 875  VEM-----SYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKED 929
            VE+       P     P I + +L  HI ++K      F +EYE++  GQ  +W+ +  +
Sbjct: 909  VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLE 968

Query: 930  ENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKD 989
             N+ KNRY N+I+YDHSRV L  ++G P SDY+NANYIDGY +   YIATQG + ET  D
Sbjct: 969  VNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGD 1028

Query: 990  FWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTF 1048
            FWRMIW++ SA++VM+T L E  RVKC +YWP   TE +G ++VTL++T  LA Y +RTF
Sbjct: 1029 FWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTF 1088

Query: 1049 TVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAG 1108
             + K G  E RE+R F FT+WPDHGVP + T  L F+R+VK  NPP+AGP+VVHCSAG G
Sbjct: 1089 ALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVG 1148

Query: 1109 RTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNT 1168
            RTGCFI ID ML+  ++E  VDI+  V  +RAQR  +VQTE+QY+F+HDA+LEA  CGNT
Sbjct: 1149 RTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNT 1208

Query: 1169 AIPVCEFRSLYYNISRLDP-QTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRS 1227
             +P    R+LY  I +L   +T  +    E +   + + +          LP N  KNR 
Sbjct: 1209 EVPA---RNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRL 1265

Query: 1228 MDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDY 1286
            ++++P +     L  + G E S+YINA+ +D ++Q  A++ TQ PL  T  DFWR+++++
Sbjct: 1266 VNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEH 1325

Query: 1287 NCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARP 1344
            N + VVML ++     + C QYWP + S  Y    V+ ++       I R F++ +    
Sbjct: 1326 NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDG 1385

Query: 1345 QDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRS 1404
            Q   R V+  Q+  WP  +  P S    +  + ++ K +EQ+ G++G   VHC  G GR+
Sbjct: 1386 QS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRT 1441

Query: 1405 GTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1460
            G F  +  V E ++ + ++D+F  VK LR  +  MV+T +QY+F Y  ALEYL SF
Sbjct: 1442 GVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1497



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 82/325 (25%), Positives = 133/325 (40%), Gaps = 34/325 (10%)

Query: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316
           R  + Y CV  S  G  +   A++ VK  P P   P   E  A   T  W   N   +  
Sbjct: 292 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 348

Query: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
                + + + + +   + E   V +  Y +  L P  +YE RV+       G GPP  P
Sbjct: 349 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 404

Query: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432
           + T+T    P   P++V+   + +  + +QW    EP G  +     Y      Q+V N 
Sbjct: 405 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 463

Query: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490
            ++     +  S   T+  L P  T  +++L   S  +G + S+  V+ T+  VPG  PL
Sbjct: 464 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 517

Query: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550
                   E  I + W PP   +  I  YE+ YK  G       ++ + G  ++L+    
Sbjct: 518 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 570

Query: 551 HLFVGLYPGTTYSFTIKASTAKGFG 575
               GL P + Y F + A + +G G
Sbjct: 571 ----GLKPNSLYYFRLAARSPQGLG 591


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score =  490 bits (1261), Expect = e-138
 Identities = 356/1115 (31%), Positives = 536/1115 (48%), Gaps = 165/1115 (14%)

Query: 386  PVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSS 445
            P   PQN+      +  + L W+P   A         T+ Y+ +        + ++   +
Sbjct: 918  PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT 977

Query: 446  HYTLRGLRPFMTIRLRLLLSNPEGRME-SEELVVQTEEDVPGAVPLESIQGGPFEEK--- 501
              TL GL+P  T  +++     +G    S  +  +T       +P++ +    F  K   
Sbjct: 978  TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVM 1030

Query: 502  ---IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADLSSQRGKVFKLRNETHHLFVG 555
               + + W+ P   N  +  ++I Y   K V  +D  A               T  L V 
Sbjct: 1031 KTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA---------------TQKLIVN 1074

Query: 556  LYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKP 613
            L P  +YSF +  + ++A G    VT + A  +   + P +   T L   D  ITV L  
Sbjct: 1075 LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPAFIGKTNL---DGMITVQLPE 1130

Query: 614  AQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSL------------ 661
              +       Y ++V    L+KSR        F  P    +   LD L            
Sbjct: 1131 VPANENIKGYYIIIVP---LKKSRGK------FIKPWESPDEMELDELLKEISRKRRSIR 1181

Query: 662  HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKI 717
            +    ELKP   A+  V    FT+GD+K Y G+ N  L   + Y ++F      + E+K+
Sbjct: 1182 YGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKM 1240

Query: 718  NCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLL--M 775
                    +P     V                 S  ++P+   D    +  V+  +L  +
Sbjct: 1241 YAT-----SPYSDPVV-----------------SMDLDPQPITDEEEGLIWVVGPVLAVV 1278

Query: 776  FIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRN 835
            FII ++  +L  KR+R                               A+  + K S   N
Sbjct: 1279 FIICIVIAILLYKRKR-------------------------------AESDSRKSSIPNN 1307

Query: 836  DEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRV 890
             E                          I +H     DPVE+       P     P I +
Sbjct: 1308 KE--------------------------IPSH--HPTDPVELRRLNFQTPGMASHPPIPI 1339

Query: 891  ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRL 950
             +L  HI ++K      F +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L
Sbjct: 1340 LELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLL 1399

Query: 951  LVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVE 1010
              ++G P SDY+NANYIDGY +   YIATQG + ET  DFWRMIW++ SA++VM+T L E
Sbjct: 1400 SAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEE 1459

Query: 1011 VGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSW 1069
              RVKC +YWP   TE +G ++VTL++T  LA Y +RTF + K G  E RE+R F FT+W
Sbjct: 1460 RSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAW 1519

Query: 1070 PDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVV 1129
            PDHGVP + T  L F+R+VK  NPP+AGP+VVHCSAG GRTGCFI ID ML+  ++E  V
Sbjct: 1520 PDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTV 1579

Query: 1130 DIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP-Q 1188
            DI+  V  +RAQR  +VQTE+QY+F+HDA+LEA  CGNT +P    R+LY  I +L   +
Sbjct: 1580 DIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA---RNLYAYIQKLTQIE 1636

Query: 1189 TNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ES 1247
            T  +    E +   + + +          LP N  KNR ++++P +     L  + G E 
Sbjct: 1637 TGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG 1696

Query: 1248 SNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQ 1305
            S+YINA+ +D ++Q  A++ TQ PL  T  DFWR+++++N + VVML ++     + C Q
Sbjct: 1697 SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQ 1756

Query: 1306 YWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDT 1365
            YWP + S  Y    V+ ++       I R F++ +    Q   R V+  Q+  WP  +  
Sbjct: 1757 YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGV 1813

Query: 1366 PPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDV 1425
            P S    +  + ++ K +EQ+ G++G   VHC  G GR+G F  +  V E ++ + ++D+
Sbjct: 1814 PKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDI 1872

Query: 1426 FHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1460
            F  VK LR  +  MV+T +QY+F Y  ALEYL SF
Sbjct: 1873 FQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1907



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 93/378 (24%), Positives = 152/378 (40%), Gaps = 36/378 (9%)

Query: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316
           R  + Y CV  S  G  +   A++ VK  P P   P   E  A   T  W   N   +  
Sbjct: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 351

Query: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
                + + + + +   + E   V +  Y +  L P  +YE RV+       G GPP  P
Sbjct: 352 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 407

Query: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432
           + T+T    P   P++V+   + +  + +QW    EP G  +     Y      Q+V N 
Sbjct: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 466

Query: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490
            ++     +  S   T+  L P  T  +++L   S  +G + S+  V+ T+  VPG  PL
Sbjct: 467 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 520

Query: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550
                   E  I + W PP   +  I  YE+ YK  G       ++ + G  ++L+    
Sbjct: 521 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 573

Query: 551 HLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIA-TKISAPSMPEYDTD-TPLNETDTTIT 608
               GL P + Y F + A + +G G       A T  S PS P  D   T  + T   ++
Sbjct: 574 ----GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 629

Query: 609 VMLKPAQSRGAPVSVYQL 626
               P + +   ++ Y +
Sbjct: 630 WQPPPVEKQNGIITEYSI 647



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 83/353 (23%), Positives = 137/353 (38%), Gaps = 30/353 (8%)

Query: 253 SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306
           SVA  +  S  ++R V  ++ G G  +   L       P + P       L +      W
Sbjct: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438

Query: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366
            +P   +    G  +   ++       W + ++ DS    + +L P   Y ++VL     
Sbjct: 439 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 496

Query: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
             G GP    +   T+   P   P N +        + L W P           +    Y
Sbjct: 497 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 547

Query: 427 QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE-ELVVQTEED 483
           + V+   ++  E+   I+  + Y L+GL+P      RL   +P+G   S  E+  +T + 
Sbjct: 548 ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607

Query: 484 VPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLDPSADLSSQRGK 541
            P A P +     P    I + W+PP   + NG+IT Y I Y AV   D       +  +
Sbjct: 608 KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGED------DKPHE 661

Query: 542 VFKLRNE-THHLFVGLYPGTTYSFTIKASTAKGFGP-PVTTRIATKISAPSMP 592
           +  + ++ T +L   L   T Y  T+ A T  G GP  ++  I T    PS P
Sbjct: 662 ILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 714



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 82/346 (23%), Positives = 126/346 (36%), Gaps = 54/346 (15%)

Query: 263  SKYRCVI--RSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL---WIKPNANSI 314
            ++YR  +   +D G G  + + LI      P  PP   E+ AV +T +   W  P  N  
Sbjct: 681  TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 740

Query: 315  IGD-----------------GPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357
             G                  G  +LK+V        + +T   D     +  L P+  Y 
Sbjct: 741  HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI---ISGLQPETSYS 797

Query: 358  IRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTR 416
            + V   T  G+G    P    TT       V G   + I   +     +QW P       
Sbjct: 798  LTVTAYTTKGDGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHP------P 846

Query: 417  CHSYNLTVQYQYVFNQQQYEAEEVIQTSS---HYTLRGLRPFMTIRLRLLLSNPEGRMES 473
              ++     Y+  F ++  E    ++ S    H+T   +    +   RL   N  G  E 
Sbjct: 847  VDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEE 906

Query: 474  EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVG-SLD 530
                +   E+VP   P      G     + + W+PP   E NG+IT Y + Y+ +   L 
Sbjct: 907  MVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLL 966

Query: 531  PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGP 576
            P   L         +  +T     GL P TTY   ++A T+KG GP
Sbjct: 967  PMEQLI--------VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 1004



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 91/409 (22%), Positives = 154/409 (37%), Gaps = 66/409 (16%)

Query: 261 SVSKYRCVIRSDGGSGVSNYAELIVKEPPT-PIAPPELLAVGATYLWIKPNANSII---- 315
           S+  +R   RS  G G S  AE+  +   + P APP+ ++  +      P++ SI+    
Sbjct: 579 SLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTS------PSSTSILVSWQ 631

Query: 316 ------GDGPIILKEVEYRTTTGTWAETHIV-----DSPNYKLWHLDPDVEYEIRVLLTR 364
                  +G I    ++Y    G   + H +     D+  Y L  L+   EY  R+ +T 
Sbjct: 632 PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RITVTA 689

Query: 365 PGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEP----------FGYAV 414
             + G GP    +  RT    P   P+ VE+  + +  + + W             GY V
Sbjct: 690 HTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 749

Query: 415 TRCHSYNLTVQYQYVFNQ-----QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEG 469
                 N   + Q +         Q+E ++   T     + GL+P  +  L +     +G
Sbjct: 750 HYVRMENGEPKGQPMLKDVMLADAQWEFDDT--TEHDMIISGLQPETSYSLTVTAYTTKG 807

Query: 470 R-MESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGS 528
               S+  +V T   VPG   L  +          IQW PP +T G +  Y + +     
Sbjct: 808 DGARSKPKLVSTTGAVPGKPRL--VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRK-D 864

Query: 529 LDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISA 588
           ++P   L            E H     ++ G +Y F + A    GFG      +  +IS 
Sbjct: 865 MEPLTTLEFSE-------KEDHFTATDIHKGASYVFRLSARNKVGFG----EEMVKEISI 913

Query: 589 PSMPEYDTDTPLN-----ETDTTITVMLKP--AQSRGAPVSVYQLVVKE 630
           P   E  T  P N      T T++ +  +P     R   ++ Y L+ ++
Sbjct: 914 PE--EVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 960


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score =  490 bits (1261), Expect = e-138
 Identities = 356/1115 (31%), Positives = 536/1115 (48%), Gaps = 165/1115 (14%)

Query: 386  PVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSS 445
            P   PQN+      +  + L W+P   A         T+ Y+ +        + ++   +
Sbjct: 905  PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT 964

Query: 446  HYTLRGLRPFMTIRLRLLLSNPEGRME-SEELVVQTEEDVPGAVPLESIQGGPFEEK--- 501
              TL GL+P  T  +++     +G    S  +  +T       +P++ +    F  K   
Sbjct: 965  TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVM 1017

Query: 502  ---IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADLSSQRGKVFKLRNETHHLFVG 555
               + + W+ P   N  +  ++I Y   K V  +D  A               T  L V 
Sbjct: 1018 KTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA---------------TQKLIVN 1061

Query: 556  LYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKP 613
            L P  +YSF +  + ++A G    VT + A  +   + P +   T L   D  ITV L  
Sbjct: 1062 LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPAFIGKTNL---DGMITVQLPE 1117

Query: 614  AQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSL------------ 661
              +       Y ++V    L+KSR        F  P    +   LD L            
Sbjct: 1118 VPANENIKGYYIIIVP---LKKSRGK------FIKPWESPDEMELDELLKEISRKRRSIR 1168

Query: 662  HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKI 717
            +    ELKP   A+  V    FT+GD+K Y G+ N  L   + Y ++F      + E+K+
Sbjct: 1169 YGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKM 1227

Query: 718  NCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLL--M 775
                    +P     V                 S  ++P+   D    +  V+  +L  +
Sbjct: 1228 YAT-----SPYSDPVV-----------------SMDLDPQPITDEEEGLIWVVGPVLAVV 1265

Query: 776  FIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRN 835
            FII ++  +L  KR+R                               A+  + K S   N
Sbjct: 1266 FIICIVIAILLYKRKR-------------------------------AESDSRKSSIPNN 1294

Query: 836  DEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRV 890
             E                          I +H     DPVE+       P     P I +
Sbjct: 1295 KE--------------------------IPSH--HPTDPVELRRLNFQTPGMASHPPIPI 1326

Query: 891  ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRL 950
             +L  HI ++K      F +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L
Sbjct: 1327 LELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLL 1386

Query: 951  LVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVE 1010
              ++G P SDY+NANYIDGY +   YIATQG + ET  DFWRMIW++ SA++VM+T L E
Sbjct: 1387 SAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEE 1446

Query: 1011 VGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSW 1069
              RVKC +YWP   TE +G ++VTL++T  LA Y +RTF + K G  E RE+R F FT+W
Sbjct: 1447 RSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAW 1506

Query: 1070 PDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVV 1129
            PDHGVP + T  L F+R+VK  NPP+AGP+VVHCSAG GRTGCFI ID ML+  ++E  V
Sbjct: 1507 PDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTV 1566

Query: 1130 DIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP-Q 1188
            DI+  V  +RAQR  +VQTE+QY+F+HDA+LEA  CGNT +P    R+LY  I +L   +
Sbjct: 1567 DIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA---RNLYAYIQKLTQIE 1623

Query: 1189 TNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ES 1247
            T  +    E +   + + +          LP N  KNR ++++P +     L  + G E 
Sbjct: 1624 TGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG 1683

Query: 1248 SNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQ 1305
            S+YINA+ +D ++Q  A++ TQ PL  T  DFWR+++++N + VVML ++     + C Q
Sbjct: 1684 SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQ 1743

Query: 1306 YWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDT 1365
            YWP + S  Y    V+ ++       I R F++ +    Q   R V+  Q+  WP  +  
Sbjct: 1744 YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGV 1800

Query: 1366 PPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDV 1425
            P S    +  + ++ K +EQ+ G++G   VHC  G GR+G F  +  V E ++ + ++D+
Sbjct: 1801 PKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDI 1859

Query: 1426 FHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1460
            F  VK LR  +  MV+T +QY+F Y  ALEYL SF
Sbjct: 1860 FQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1894



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 93/378 (24%), Positives = 152/378 (40%), Gaps = 36/378 (9%)

Query: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316
           R  + Y CV  S  G  +   A++ VK  P P   P   E  A   T  W   N   +  
Sbjct: 282 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 338

Query: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
                + + + + +   + E   V +  Y +  L P  +YE RV+       G GPP  P
Sbjct: 339 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 394

Query: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432
           + T+T    P   P++V+   + +  + +QW    EP G  +     Y      Q+V N 
Sbjct: 395 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 453

Query: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490
            ++     +  S   T+  L P  T  +++L   S  +G + S+  V+ T+  VPG  PL
Sbjct: 454 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 507

Query: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550
                   E  I + W PP   +  I  YE+ YK  G       ++ + G  ++L+    
Sbjct: 508 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 560

Query: 551 HLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIA-TKISAPSMPEYDTD-TPLNETDTTIT 608
               GL P + Y F + A + +G G       A T  S PS P  D   T  + T   ++
Sbjct: 561 ----GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 616

Query: 609 VMLKPAQSRGAPVSVYQL 626
               P + +   ++ Y +
Sbjct: 617 WQPPPVEKQNGIITEYSI 634



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 83/353 (23%), Positives = 137/353 (38%), Gaps = 30/353 (8%)

Query: 253 SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306
           SVA  +  S  ++R V  ++ G G  +   L       P + P       L +      W
Sbjct: 366 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 425

Query: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366
            +P   +    G  +   ++       W + ++ DS    + +L P   Y ++VL     
Sbjct: 426 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 483

Query: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
             G GP    +   T+   P   P N +        + L W P           +    Y
Sbjct: 484 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 534

Query: 427 QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE-ELVVQTEED 483
           + V+   ++  E+   I+  + Y L+GL+P      RL   +P+G   S  E+  +T + 
Sbjct: 535 ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 594

Query: 484 VPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLDPSADLSSQRGK 541
            P A P +     P    I + W+PP   + NG+IT Y I Y AV   D       +  +
Sbjct: 595 KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGED------DKPHE 648

Query: 542 VFKLRNE-THHLFVGLYPGTTYSFTIKASTAKGFGP-PVTTRIATKISAPSMP 592
           +  + ++ T +L   L   T Y  T+ A T  G GP  ++  I T    PS P
Sbjct: 649 ILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 701



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 82/346 (23%), Positives = 126/346 (36%), Gaps = 54/346 (15%)

Query: 263 SKYRCVI--RSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL---WIKPNANSI 314
           ++YR  +   +D G G  + + LI      P  PP   E+ AV +T +   W  P  N  
Sbjct: 668 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 727

Query: 315 IGD-----------------GPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYE 357
            G                  G  +LK+V        + +T   D     +  L P+  Y 
Sbjct: 728 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI---ISGLQPETSYS 784

Query: 358 IRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTR 416
           + V   T  G+G    P    TT       V G   + I   +     +QW P       
Sbjct: 785 LTVTAYTTKGDGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHP------P 833

Query: 417 CHSYNLTVQYQYVFNQQQYEAEEVIQTSS---HYTLRGLRPFMTIRLRLLLSNPEGRMES 473
             ++     Y+  F ++  E    ++ S    H+T   +    +   RL   N  G  E 
Sbjct: 834 VDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEE 893

Query: 474 EELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVG-SLD 530
               +   E+VP   P      G     + + W+PP   E NG+IT Y + Y+ +   L 
Sbjct: 894 MVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLL 953

Query: 531 PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGP 576
           P   L         +  +T     GL P TTY   ++A T+KG GP
Sbjct: 954 PMEQLI--------VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 991



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 91/409 (22%), Positives = 154/409 (37%), Gaps = 66/409 (16%)

Query: 261 SVSKYRCVIRSDGGSGVSNYAELIVKEPPT-PIAPPELLAVGATYLWIKPNANSII---- 315
           S+  +R   RS  G G S  AE+  +   + P APP+ ++  +      P++ SI+    
Sbjct: 566 SLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTS------PSSTSILVSWQ 618

Query: 316 ------GDGPIILKEVEYRTTTGTWAETHIV-----DSPNYKLWHLDPDVEYEIRVLLTR 364
                  +G I    ++Y    G   + H +     D+  Y L  L+   EY  R+ +T 
Sbjct: 619 PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RITVTA 676

Query: 365 PGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEP----------FGYAV 414
             + G GP    +  RT    P   P+ VE+  + +  + + W             GY V
Sbjct: 677 HTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV 736

Query: 415 TRCHSYNLTVQYQYVFNQ-----QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEG 469
                 N   + Q +         Q+E ++   T     + GL+P  +  L +     +G
Sbjct: 737 HYVRMENGEPKGQPMLKDVMLADAQWEFDDT--TEHDMIISGLQPETSYSLTVTAYTTKG 794

Query: 470 R-MESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGS 528
               S+  +V T   VPG   L  +          IQW PP +T G +  Y + +     
Sbjct: 795 DGARSKPKLVSTTGAVPGKPRL--VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRK-D 851

Query: 529 LDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISA 588
           ++P   L            E H     ++ G +Y F + A    GFG      +  +IS 
Sbjct: 852 MEPLTTLEFSE-------KEDHFTATDIHKGASYVFRLSARNKVGFG----EEMVKEISI 900

Query: 589 PSMPEYDTDTPLN-----ETDTTITVMLKP--AQSRGAPVSVYQLVVKE 630
           P   E  T  P N      T T++ +  +P     R   ++ Y L+ ++
Sbjct: 901 PE--EVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 947


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score =  490 bits (1261), Expect = e-138
 Identities = 356/1115 (31%), Positives = 536/1115 (48%), Gaps = 165/1115 (14%)

Query: 386  PVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSS 445
            P   PQN+      +  + L W+P   A         T+ Y+ +        + ++   +
Sbjct: 909  PTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT 968

Query: 446  HYTLRGLRPFMTIRLRLLLSNPEGRME-SEELVVQTEEDVPGAVPLESIQGGPFEEK--- 501
              TL GL+P  T  +++     +G    S  +  +T       +P++ +    F  K   
Sbjct: 969  TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-------LPVDQVFAKNFHVKAVM 1021

Query: 502  ---IYIQWKPPNETNGVITLYEINY---KAVGSLDPSADLSSQRGKVFKLRNETHHLFVG 555
               + + W+ P   N  +  ++I Y   K V  +D  A               T  L V 
Sbjct: 1022 KTSVLLSWEIPENYNSAMP-FKILYDDGKMVEEVDGRA---------------TQKLIVN 1065

Query: 556  LYPGTTYSFTI--KASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKP 613
            L P  +YSF +  + ++A G    VT + A  +   + P +   T L   D  ITV L  
Sbjct: 1066 LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLR-TKPAFIGKTNL---DGMITVQLPE 1121

Query: 614  AQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSL------------ 661
              +       Y ++V    L+KSR        F  P    +   LD L            
Sbjct: 1122 VPANENIKGYYIIIVP---LKKSRGK------FIKPWESPDEMELDELLKEISRKRRSIR 1172

Query: 662  HYFAAELKP---ANLPVTQP-FTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKI 717
            +    ELKP   A+  V    FT+GD+K Y G+ N  L   + Y ++F      + E+K+
Sbjct: 1173 YGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEY-VFFVLAVMEHAESKM 1231

Query: 718  NCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLL--M 775
                    +P     V                 S  ++P+   D    +  V+  +L  +
Sbjct: 1232 YAT-----SPYSDPVV-----------------SMDLDPQPITDEEEGLIWVVGPVLAVV 1269

Query: 776  FIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRN 835
            FII ++  +L  KR+R                               A+  + K S   N
Sbjct: 1270 FIICIVIAILLYKRKR-------------------------------AESDSRKSSIPNN 1298

Query: 836  DEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEM-----SYPRDQFQPAIRV 890
             E                          I +H     DPVE+       P     P I +
Sbjct: 1299 KE--------------------------IPSH--HPTDPVELRRLNFQTPGMASHPPIPI 1330

Query: 891  ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRL 950
             +L  HI ++K      F +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L
Sbjct: 1331 LELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLL 1390

Query: 951  LVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVE 1010
              ++G P SDY+NANYIDGY +   YIATQG + ET  DFWRMIW++ SA++VM+T L E
Sbjct: 1391 SAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEE 1450

Query: 1011 VGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSW 1069
              RVKC +YWP   TE +G ++VTL++T  LA Y +RTF + K G  E RE+R F FT+W
Sbjct: 1451 RSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAW 1510

Query: 1070 PDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVV 1129
            PDHGVP + T  L F+R+VK  NPP+AGP+VVHCSAG GRTGCFI ID ML+  ++E  V
Sbjct: 1511 PDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTV 1570

Query: 1130 DIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP-Q 1188
            DI+  V  +RAQR  +VQTE+QY+F+HDA+LEA  CGNT +P    R+LY  I +L   +
Sbjct: 1571 DIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA---RNLYAYIQKLTQIE 1627

Query: 1189 TNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ES 1247
            T  +    E +   + + +          LP N  KNR ++++P +     L  + G E 
Sbjct: 1628 TGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG 1687

Query: 1248 SNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQ 1305
            S+YINA+ +D ++Q  A++ TQ PL  T  DFWR+++++N + VVML ++     + C Q
Sbjct: 1688 SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQ 1747

Query: 1306 YWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDT 1365
            YWP + S  Y    V+ ++       I R F++ +    Q   R V+  Q+  WP  +  
Sbjct: 1748 YWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGV 1804

Query: 1366 PPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDV 1425
            P S    +  + ++ K +EQ+ G++G   VHC  G GR+G F  +  V E ++ + ++D+
Sbjct: 1805 PKSGEGFIDFIGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDI 1863

Query: 1426 FHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1460
            F  VK LR  +  MV+T +QY+F Y  ALEYL SF
Sbjct: 1864 FQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSF 1898



 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 93/378 (24%), Positives = 152/378 (40%), Gaps = 36/378 (9%)

Query: 260 RSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYLWIKPNANSIIG 316
           R  + Y CV  S  G  +   A++ VK  P P   P   E  A   T  W   N   +  
Sbjct: 295 RQSANYTCVAMSTLGV-IEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPV-- 351

Query: 317 DGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPP 376
                + + + + +   + E   V +  Y +  L P  +YE RV+       G GPP  P
Sbjct: 352 --SYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVN--NIGRGPPSEP 407

Query: 377 LTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHSYNLTVQYQYVFNQ 432
           + T+T    P   P++V+   + +  + +QW    EP G  +     Y      Q+V N 
Sbjct: 408 VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG-QIQGYRVYYTMDPTQHVNNW 466

Query: 433 QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL--LSNPEGRMESEELVVQTEEDVPGAVPL 490
            ++     +  S   T+  L P  T  +++L   S  +G + S+  V+ T+  VPG  PL
Sbjct: 467 MKHN----VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVI-TQTGVPGQ-PL 520

Query: 491 ESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETH 550
                   E  I + W PP   +  I  YE+ YK  G       ++ + G  ++L+    
Sbjct: 521 NFKAEPESETSILLSWTPPR--SDTIANYELVYKD-GEHGEEQRITIEPGTSYRLQ---- 573

Query: 551 HLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIA-TKISAPSMPEYDTD-TPLNETDTTIT 608
               GL P + Y F + A + +G G       A T  S PS P  D   T  + T   ++
Sbjct: 574 ----GLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVS 629

Query: 609 VMLKPAQSRGAPVSVYQL 626
               P + +   ++ Y +
Sbjct: 630 WQPPPVEKQNGIITEYSI 647



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 83/353 (23%), Positives = 137/353 (38%), Gaps = 30/353 (8%)

Query: 253 SVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPE------LLAVGATYLW 306
           SVA  +  S  ++R V  ++ G G  +   L       P + P       L +      W
Sbjct: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438

Query: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPG 366
            +P   +    G  +   ++       W + ++ DS    + +L P   Y ++VL     
Sbjct: 439 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFT-- 496

Query: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
             G GP    +   T+   P   P N +        + L W P           +    Y
Sbjct: 497 SIGDGPLSSDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP--------PRSDTIANY 547

Query: 427 QYVFNQQQYEAEE--VIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESE-ELVVQTEED 483
           + V+   ++  E+   I+  + Y L+GL+P      RL   +P+G   S  E+  +T + 
Sbjct: 548 ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQS 607

Query: 484 VPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLDPSADLSSQRGK 541
            P A P +     P    I + W+PP   + NG+IT Y I Y AV   D       +  +
Sbjct: 608 KPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGED------DKPHE 661

Query: 542 VFKLRNE-THHLFVGLYPGTTYSFTIKASTAKGFGP-PVTTRIATKISAPSMP 592
           +  + ++ T +L   L   T Y  T+ A T  G GP  ++  I T    PS P
Sbjct: 662 ILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 714



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 82/336 (24%), Positives = 127/336 (37%), Gaps = 43/336 (12%)

Query: 263 SKYRCVI--RSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL---WIKPNANSI 314
           ++YR  +   +D G G  + + LI      P  PP   E+ AV +T +   W  P  N  
Sbjct: 681 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK- 739

Query: 315 IGDGPIILKEVEY-RTTTGT------WAETHIVDSPNYKLWHLDPDVEYEIRVLL-TRPG 366
              G I   +V Y R   G         +  + D+ +  +  L P+  Y + V   T  G
Sbjct: 740 -QHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKG 798

Query: 367 EGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY 426
           +G    P    TT       V G   + I   +     +QW P         ++     Y
Sbjct: 799 DGARSKPKLVSTTGA-----VPGKPRLVINHTQMNTALIQWHP------PVDTFGPLQGY 847

Query: 427 QYVFNQQQYEAEEVIQTSS---HYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEED 483
           +  F ++  E    ++ S    H+T   +    +   RL   N  G  E     +   E+
Sbjct: 848 RLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEE 907

Query: 484 VPGAVPLESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVG-SLDPSADLSSQRG 540
           VP   P      G     + + W+PP   E NG+IT Y + Y+ +   L P   L     
Sbjct: 908 VPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLI---- 963

Query: 541 KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGP 576
               +  +T     GL P TTY   ++A T+KG GP
Sbjct: 964 ----VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 995



 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 88/400 (22%), Positives = 152/400 (38%), Gaps = 57/400 (14%)

Query: 261 SVSKYRCVIRSDGGSGVSNYAELIVKEPPT-PIAPPELLAVGATYLWIKPNANSII---- 315
           S+  +R   RS  G G S  AE+  +   + P APP+ ++  +      P++ SI+    
Sbjct: 579 SLYYFRLAARSPQGLGAST-AEISARTMQSKPSAPPQDISCTS------PSSTSILVSWQ 631

Query: 316 ------GDGPIILKEVEYRTTTGTWAETHIV-----DSPNYKLWHLDPDVEYEIRVLLTR 364
                  +G I    ++Y    G   + H +     D+  Y L  L+   EY  R+ +T 
Sbjct: 632 PPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RITVTA 689

Query: 365 PGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTV 424
             + G GP    +  RT    P   P+ VE+  + +  + + W        + H      
Sbjct: 690 HTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWR--SPVPNKQHGQIRGY 747

Query: 425 QYQYVFNQ------QQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGR-MESEELV 477
           Q  YV  +      Q    + ++  +    + GL+P  +  L +     +G    S+  +
Sbjct: 748 QVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKL 807

Query: 478 VQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSS 537
           V T   VPG   L  +          IQW PP +T G +  Y + +     ++P   L  
Sbjct: 808 VSTTGAVPGKPRL--VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRK-DMEPLTTLEF 864

Query: 538 QRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTD 597
                     E H     ++ G +Y F + A    GFG      +  +IS P   E  T 
Sbjct: 865 SE-------KEDHFTATDIHKGASYVFRLSARNKVGFG----EEMVKEISIPE--EVPTG 911

Query: 598 TPLN-----ETDTTITVMLKP--AQSRGAPVSVYQLVVKE 630
            P N      T T++ +  +P     R   ++ Y L+ ++
Sbjct: 912 FPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 951


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score =  473 bits (1217), Expect = e-133
 Identities = 251/604 (41%), Positives = 368/604 (60%), Gaps = 19/604 (3%)

Query: 868  PYRTCDPVEMSYPRDQFQ-------PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQT 920
            P+   DPVEM   R  FQ       P I +AD+ +H  ++K        +EYE++  GQ 
Sbjct: 905  PHHPKDPVEMR--RINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQ 962

Query: 921  ASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQ 980
             +W+ +  + N+ KNRY N+I+YDHSRV L  ++G   SDYINANY+DGY     YIATQ
Sbjct: 963  FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQ 1022

Query: 981  GPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIETEP 1039
            GP+ ET  DFWRM+W++ SA+IVM+T L E  R+KC +YWP+  TE YG I+VTL++T  
Sbjct: 1023 GPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIE 1082

Query: 1040 LAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPI 1099
            LA + +RTF++ K G  E RE+R F FT+WPDHGVP Y T  L F+R+VK  NPP+AGPI
Sbjct: 1083 LATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPI 1142

Query: 1100 VVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1159
            VVHCSAG GRTGCFI ID ML+  + E  VD++  V  +R+QR  +VQTE+QY F+H+A+
Sbjct: 1143 VVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1202

Query: 1160 LEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLP 1219
            LEA  CGNT +P     +    +++++P  + + ++ EF+ L     +          LP
Sbjct: 1203 LEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLP 1260

Query: 1220 RNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVAD 1278
             N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++ TQ PL  T  D
Sbjct: 1261 CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1320

Query: 1279 FWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIF 1336
            FWR++++ N + VVML ++     + C QYWP + S  Y    V+ ++       I R F
Sbjct: 1321 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1380

Query: 1337 RICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVH 1396
            ++ +    Q   R V+  Q+  WP  +  P S    +  + ++ K +EQ+ G++G   VH
Sbjct: 1381 KVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVH 1436

Query: 1397 CLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY 1456
            C  G GR+G F  +  V E ++ + ++D+F  VK LR  +  MV+T ++Y+F Y+ ALEY
Sbjct: 1437 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1496

Query: 1457 LSSF 1460
            L SF
Sbjct: 1497 LGSF 1500



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 109/420 (25%), Positives = 174/420 (41%), Gaps = 49/420 (11%)

Query: 182 VRVLAHPCRKAPHFLRL-QNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT 240
           VR L    R AP F  L  + E+  G N    C+A G    + K W+Q   G +      
Sbjct: 225 VRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK-WMQ---GAEDLTPED 280

Query: 241 RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---EL 297
            +   R       V D+A      Y CV  S  G  +   A++ VK  P     P   E 
Sbjct: 281 DMPVGRNVLELTDVKDSAN-----YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTEN 334

Query: 298 LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTT--GTWAETHIVDSPNYKLWHLDPDVE 355
            A   T  W   N +      P+    +EY++ +  G +     + +  Y +  L P+ E
Sbjct: 335 TATSITITWDSGNPD------PVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSE 388

Query: 356 YEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFG 411
           YEI V  +     G GPP   + TRT    P   P+NV+   + A  + +QW    EP G
Sbjct: 389 YEIWV--SAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNG 446

Query: 412 YAVTRCHSYNLTVQYQY-VFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGR 470
             + R +    T++ ++ V N Q++  ++ + T+    L       T+R+    S  +G 
Sbjct: 447 --LIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLED--ETYTVRVLAFTSVGDGP 502

Query: 471 MESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLD 530
           + S+ + V+T++ VPG  P+        E  I + W PP + +  I  YE+ ++      
Sbjct: 503 L-SDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFR------ 552

Query: 531 PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFG---PPVTTRIATKIS 587
              D   + G+ F     T ++   L P T Y+F + A + +G G   P V  R    IS
Sbjct: 553 -EGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSIS 609


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score =  473 bits (1217), Expect = e-133
 Identities = 251/604 (41%), Positives = 368/604 (60%), Gaps = 19/604 (3%)

Query: 868  PYRTCDPVEMSYPRDQFQ-------PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQT 920
            P+   DPVEM   R  FQ       P I +AD+ +H  ++K        +EYE++  GQ 
Sbjct: 1310 PHHPKDPVEMR--RINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQ 1367

Query: 921  ASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQ 980
             +W+ +  + N+ KNRY N+I+YDHSRV L  ++G   SDYINANY+DGY     YIATQ
Sbjct: 1368 FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQ 1427

Query: 981  GPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIETEP 1039
            GP+ ET  DFWRM+W++ SA+IVM+T L E  R+KC +YWP+  TE YG I+VTL++T  
Sbjct: 1428 GPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIE 1487

Query: 1040 LAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPI 1099
            LA + +RTF++ K G  E RE+R F FT+WPDHGVP Y T  L F+R+VK  NPP+AGPI
Sbjct: 1488 LATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPI 1547

Query: 1100 VVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1159
            VVHCSAG GRTGCFI ID ML+  + E  VD++  V  +R+QR  +VQTE+QY F+H+A+
Sbjct: 1548 VVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1607

Query: 1160 LEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLP 1219
            LEA  CGNT +P     +    +++++P  + + ++ EF+ L     +          LP
Sbjct: 1608 LEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLP 1665

Query: 1220 RNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVAD 1278
             N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++ TQ PL  T  D
Sbjct: 1666 CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1725

Query: 1279 FWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIF 1336
            FWR++++ N + VVML ++     + C QYWP + S  Y    V+ ++       I R F
Sbjct: 1726 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1785

Query: 1337 RICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVH 1396
            ++ +    Q   R V+  Q+  WP  +  P S    +  + ++ K +EQ+ G++G   VH
Sbjct: 1786 KVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVH 1841

Query: 1397 CLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY 1456
            C  G GR+G F  +  V E ++ + ++D+F  VK LR  +  MV+T ++Y+F Y+ ALEY
Sbjct: 1842 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1901

Query: 1457 LSSF 1460
            L SF
Sbjct: 1902 LGSF 1905



 Score = 87.8 bits (216), Expect = 7e-17
 Identities = 114/437 (26%), Positives = 182/437 (41%), Gaps = 50/437 (11%)

Query: 190 RKAPHFLRL-QNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRF 248
           R AP F  L  + E+  G N    C+A G    + K W+Q   G +       +   R  
Sbjct: 229 RVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK-WMQ---GAEDLTPEDDMPVGRNV 284

Query: 249 SATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL 305
                V D+A      Y CV  S  G  +   A++ VK  P     P   E  A   T  
Sbjct: 285 LELTDVKDSAN-----YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITIT 338

Query: 306 WIKPNANSIIGDGPIILKEVEYRTTT--GTWAETHIVDSPNYKLWHLDPDVEYEIRVLLT 363
           W   N +      P+    +EY++ +  G +     + +  Y +  L P+ EYEI V  +
Sbjct: 339 WDSGNPD------PVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--S 390

Query: 364 RPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHS 419
                G GPP   + TRT    P   P+NV+   + A  + +QW    EP G  + R + 
Sbjct: 391 AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNG--LIRGYR 448

Query: 420 YNLTVQYQY-VFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVV 478
              T++ ++ V N Q++  ++ + T+    L       T+R+    S  +G + S+ + V
Sbjct: 449 VYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLED--ETYTVRVLAFTSVGDGPL-SDPIQV 505

Query: 479 QTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQ 538
           +T++ VPG  P+        E  I + W PP + +  I  YE+ ++         D   +
Sbjct: 506 KTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFR-------EGDHGRE 555

Query: 539 RGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFG--PPVTTRIATKISAPSMPEYDT 596
            G+ F     T ++   L P T Y+F + A + +G G   PV  R  T  S PS P  D 
Sbjct: 556 VGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV-VRQRTLQSKPSAPPQDV 612

Query: 597 DTPLNETDTTITVMLKP 613
              ++   T I V  +P
Sbjct: 613 KC-VSVRSTAILVSWRP 628



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 83/351 (23%), Positives = 124/351 (35%), Gaps = 26/351 (7%)

Query: 275 SGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTW 334
           S V+   E      P  +    L A      W +P   + +  G  +   +E     G W
Sbjct: 403 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNW 462

Query: 335 AETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVE 394
            + ++ DS    +  L  D  Y +RVL       G GP   P+  +T+   P   P N+ 
Sbjct: 463 QKHNVDDSLLTTVGSLLEDETYTVRVLAFT--SVGDGPLSDPIQVKTQQGVPGQ-PMNLR 519

Query: 395 IVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQY--EAEEVIQTSSHYTLRGL 452
                   +TL W P              ++Y+ +F +  +  E       ++ Y +  L
Sbjct: 520 AEARSETSITLSWSP--------PRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDL 571

Query: 453 RPFMTIRLRLLLSNPEGRMESEELVVQ-TEEDVPGAVPLESIQGGPFEEKIYIQWKPPN- 510
           +P      RL   +P+G      +V Q T +  P A P +          I + W+PP  
Sbjct: 572 KPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPP 631

Query: 511 ET-NGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKAS 569
           ET NG +  Y + Y+ +GS DP     +           T  L   L   T Y  T  A 
Sbjct: 632 ETHNGALVGYSVRYRPLGSEDPEPKEVNGIPP-----TTTQILLEALEKWTQYRITTVAH 686

Query: 570 TAKGFGP---PVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSR 617
           T  G GP   PV  R  T    PS P    +           +   PA  R
Sbjct: 687 TEVGPGPESSPVVVR--TDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 735



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 86/354 (24%), Positives = 128/354 (36%), Gaps = 35/354 (9%)

Query: 251  TVSVADTAQRSVSKYRC--VIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGAT-- 303
            T  +   A    ++YR   V  ++ G G  +   ++  +   P APP   E  A+ AT  
Sbjct: 665  TTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAI 724

Query: 304  -YLWIKPNANSIIGDGPIILKEVEYRTTTGTWA-------ETHIVDSPNYKLWHLDPDVE 355
              LW  P        G I   +V Y    G  A       +  + D+    + +L P+  
Sbjct: 725  RVLWRSPAPGR--QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETA 782

Query: 356  YEIRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEP-FGYA 413
            Y I V   T  G+G    P   +T       P    Q      + AR     WEP  G A
Sbjct: 783  YSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLAR-----WEPPAGTA 837

Query: 414  VTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMES 473
              +   Y L    +   +       E   +   YT  G+    T   RL   +  G  E 
Sbjct: 838  EDQVLGYRLQFGRE---DSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEE 894

Query: 474  EELVVQTEEDVPGAVP-LESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLD 530
               V+   ED P   P +    G      + ++W PP   E NG I  Y +  +  G+L 
Sbjct: 895  AAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALG 954

Query: 531  PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKG---FGPPVTTR 581
            P+ +  ++     +   E      GL P T Y   ++A T +G   F PPV  R
Sbjct: 955  PARE--TELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYR 1006


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
            isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score =  473 bits (1217), Expect = e-133
 Identities = 251/604 (41%), Positives = 368/604 (60%), Gaps = 19/604 (3%)

Query: 868  PYRTCDPVEMSYPRDQFQ-------PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQT 920
            P+   DPVEM   R  FQ       P I +AD+ +H  ++K        +EYE++  GQ 
Sbjct: 901  PHHPKDPVEMR--RINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQ 958

Query: 921  ASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQ 980
             +W+ +  + N+ KNRY N+I+YDHSRV L  ++G   SDYINANY+DGY     YIATQ
Sbjct: 959  FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQ 1018

Query: 981  GPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIETEP 1039
            GP+ ET  DFWRM+W++ SA+IVM+T L E  R+KC +YWP+  TE YG I+VTL++T  
Sbjct: 1019 GPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIE 1078

Query: 1040 LAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPI 1099
            LA + +RTF++ K G  E RE+R F FT+WPDHGVP Y T  L F+R+VK  NPP+AGPI
Sbjct: 1079 LATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPI 1138

Query: 1100 VVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1159
            VVHCSAG GRTGCFI ID ML+  + E  VD++  V  +R+QR  +VQTE+QY F+H+A+
Sbjct: 1139 VVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1198

Query: 1160 LEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLP 1219
            LEA  CGNT +P     +    +++++P  + + ++ EF+ L     +          LP
Sbjct: 1199 LEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLP 1256

Query: 1220 RNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVAD 1278
             N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++ TQ PL  T  D
Sbjct: 1257 CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1316

Query: 1279 FWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIF 1336
            FWR++++ N + VVML ++     + C QYWP + S  Y    V+ ++       I R F
Sbjct: 1317 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1376

Query: 1337 RICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVH 1396
            ++ +    Q   R V+  Q+  WP  +  P S    +  + ++ K +EQ+ G++G   VH
Sbjct: 1377 KVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVH 1432

Query: 1397 CLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY 1456
            C  G GR+G F  +  V E ++ + ++D+F  VK LR  +  MV+T ++Y+F Y+ ALEY
Sbjct: 1433 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1492

Query: 1457 LSSF 1460
            L SF
Sbjct: 1493 LGSF 1496



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 106/412 (25%), Positives = 171/412 (41%), Gaps = 49/412 (11%)

Query: 190 RKAPHFLRL-QNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRF 248
           R AP F  L  + E+  G N    C+A G    + K W+Q   G +       +   R  
Sbjct: 229 RVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK-WMQ---GAEDLTPEDDMPVGRNV 284

Query: 249 SATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL 305
                V D+A      Y CV  S  G  +   A++ VK  P     P   E  A   T  
Sbjct: 285 LELTDVKDSAN-----YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITIT 338

Query: 306 WIKPNANSIIGDGPIILKEVEYRTTT--GTWAETHIVDSPNYKLWHLDPDVEYEIRVLLT 363
           W   N +      P+    +EY++ +  G +     + +  Y +  L P+ EYEI V  +
Sbjct: 339 WDSGNPD------PVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--S 390

Query: 364 RPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHS 419
                G GPP   + TRT    P   P+NV+   + A  + +QW    EP G  + R + 
Sbjct: 391 AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNG--LIRGYR 448

Query: 420 YNLTVQYQY-VFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVV 478
              T++ ++ V N Q++  ++ + T+    L       T+R+    S  +G + S+ + V
Sbjct: 449 VYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLED--ETYTVRVLAFTSVGDGPL-SDPIQV 505

Query: 479 QTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQ 538
           +T++ VPG  P+        E  I + W PP + +  I  YE+ ++         D   +
Sbjct: 506 KTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFR-------EGDHGRE 555

Query: 539 RGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFG---PPVTTRIATKIS 587
            G+ F     T ++   L P T Y+F + A + +G G   P V  R    IS
Sbjct: 556 VGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSIS 605


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score =  468 bits (1205), Expect = e-131
 Identities = 316/985 (32%), Positives = 488/985 (49%), Gaps = 117/985 (11%)

Query: 502  IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561
            + + W+ P+  N   T Y+I Y  + +LD                  T  L   L P T 
Sbjct: 1050 VLLSWEFPDNYNSP-TPYKIQYNGL-TLDVDG-------------RTTKKLITHLKPHTF 1094

Query: 562  YSFTI--KASTAKGFGPPVTTRIATKI--SAPSMPEYDTDTPLNETDTTITVMLKPAQSR 617
            Y+F +  + S+  G    VT   A  +    PS+       P  + D  I V L   QS 
Sbjct: 1095 YNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQS- 1147

Query: 618  GAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANL---- 673
              PV V    +    L+KSR        F  P+       L+ L    + L+  +L    
Sbjct: 1148 --PVPVQSYFIVMVPLRKSRGGQ-----FLTPLGSPEDMDLEELIQDISRLQRRSLRHSR 1200

Query: 674  --PVTQPFTV------------GDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINC 719
               V +P+              GD K Y G+ N  L P   Y ++  A+           
Sbjct: 1201 QLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAV----------- 1249

Query: 720  VRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIII 779
                         +    P    +  +     +  +P+  VD    +  VI G ++ ++ 
Sbjct: 1250 -------------LQKSEPTFAASPFSDPFQLDNPDPQPIVDGEEGLIWVI-GPVLAVVF 1295

Query: 780  LLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGF 839
            ++ +++ I   +N        K   K+K+++        P          L+     +  
Sbjct: 1296 IICIVIAILLYKN--------KPDSKRKDSE--------PRTKCLLNNADLAPHHPKDPV 1339

Query: 840  SSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQ 899
                 +      G R  L +P    ++          +S+P       I +AD+ +H  +
Sbjct: 1340 EMRRINFQTPDSGLRSPLREPGFHFES---------MLSHP------PIPIADMAEHTER 1384

Query: 900  MKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHS 959
            +K        +EYE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  ++G   S
Sbjct: 1385 LKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGS 1444

Query: 960  DYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRY 1019
            DYINANY+DGY     YIATQGP+ ET  DFWRM+W++ SA+IVM+T L E  R+KC +Y
Sbjct: 1445 DYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQY 1504

Query: 1020 WPD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYA 1078
            WP+  TE YG I+VTL++T  LA + +RTF++ K G  E RE+R F FT+WPDHGVP Y 
Sbjct: 1505 WPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYP 1564

Query: 1079 TGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVREL 1138
            T  L F+R+VK  NPP+AGPIVVHCSAG GRTGCFI ID ML+  + E  VD++  V  +
Sbjct: 1565 TPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLM 1624

Query: 1139 RAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEF 1198
            R+QR  +VQTE+QY F+H+A+LEA  CGNT +P     +    +++++P  + + ++ EF
Sbjct: 1625 RSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEF 1684

Query: 1199 QTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMD 1257
            + L     +          LP N  KNR ++++P +     L  + G E S+YINA+ +D
Sbjct: 1685 KRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFID 1742

Query: 1258 SHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCY 1315
             ++Q  A++ TQ PL  T  DFWR++++ N + VVML ++     + C QYWP + S  Y
Sbjct: 1743 GYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARY 1802

Query: 1316 GPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKV 1375
                V+ ++       I R F++ +    Q   R V+  Q+  WP  +  P S    +  
Sbjct: 1803 QYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDF 1859

Query: 1376 VRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNN 1435
            + ++ K +EQ+ G++G   VHC  G GR+G F  +  V E ++ + ++D+F  VK LR  
Sbjct: 1860 IGQVHKTKEQF-GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQ 1918

Query: 1436 KSNMVETLEQYKFVYEVALEYLSSF 1460
            +  MV+T ++Y+F Y+ ALEYL SF
Sbjct: 1919 RPAMVQTEDEYQFCYQAALEYLGSF 1943



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 117/445 (26%), Positives = 185/445 (41%), Gaps = 50/445 (11%)

Query: 182 VRVLAHPCRKAPHFLRL-QNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT 240
           VR L    R AP F  L  + E+  G N    C+A G    + K W+Q   G +      
Sbjct: 234 VRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK-WMQ---GAEDLTPED 289

Query: 241 RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---EL 297
            +   R       V D+A      Y CV  S  G  +   A++ VK  P     P   E 
Sbjct: 290 DMPVGRNVLELTDVKDSAN-----YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTEN 343

Query: 298 LAVGATYLWIKPNANSIIGDGPIILKEVEYRTTT--GTWAETHIVDSPNYKLWHLDPDVE 355
            A   T  W   N +      P+    +EY++ +  G +     + +  Y +  L P+ E
Sbjct: 344 TATSITITWDSGNPD------PVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSE 397

Query: 356 YEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFG 411
           YEI V  +     G GPP   + TRT    P   P+NV+   + A  + +QW    EP G
Sbjct: 398 YEIWV--SAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNG 455

Query: 412 YAVTRCHSYNLTVQYQY-VFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGR 470
             + R +    T++ ++ V N Q++  ++ + T+    L       T+R+    S  +G 
Sbjct: 456 --LIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLED--ETYTVRVLAFTSVGDGP 511

Query: 471 MESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLD 530
           + S+ + V+T++ VPG  P+        E  I + W PP + +  I  YE+ ++      
Sbjct: 512 L-SDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFR------ 561

Query: 531 PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFG--PPVTTRIATKISA 588
              D   + G+ F     T ++   L P T Y+F + A + +G G   PV  R  T  S 
Sbjct: 562 -EGDHGREVGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV-VRQRTLQSK 617

Query: 589 PSMPEYDTDTPLNETDTTITVMLKP 613
           PS P  D    ++   T I V  +P
Sbjct: 618 PSAPPQDVKC-VSVRSTAILVSWRP 641



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 83/351 (23%), Positives = 124/351 (35%), Gaps = 26/351 (7%)

Query: 275 SGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTW 334
           S V+   E      P  +    L A      W +P   + +  G  +   +E     G W
Sbjct: 416 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNW 475

Query: 335 AETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVE 394
            + ++ DS    +  L  D  Y +RVL       G GP   P+  +T+   P   P N+ 
Sbjct: 476 QKHNVDDSLLTTVGSLLEDETYTVRVLAFT--SVGDGPLSDPIQVKTQQGVPGQ-PMNLR 532

Query: 395 IVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQY--EAEEVIQTSSHYTLRGL 452
                   +TL W P              ++Y+ +F +  +  E       ++ Y +  L
Sbjct: 533 AEARSETSITLSWSP--------PRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDL 584

Query: 453 RPFMTIRLRLLLSNPEGRMESEELVVQ-TEEDVPGAVPLESIQGGPFEEKIYIQWKPPN- 510
           +P      RL   +P+G      +V Q T +  P A P +          I + W+PP  
Sbjct: 585 KPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPP 644

Query: 511 ET-NGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKAS 569
           ET NG +  Y + Y+ +GS DP     +           T  L   L   T Y  T  A 
Sbjct: 645 ETHNGALVGYSVRYRPLGSEDPEPKEVNGIPP-----TTTQILLEALEKWTQYRITTVAH 699

Query: 570 TAKGFGP---PVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSR 617
           T  G GP   PV  R  T    PS P    +           +   PA  R
Sbjct: 700 TEVGPGPESSPVVVR--TDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 748



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 87/364 (23%), Positives = 129/364 (35%), Gaps = 46/364 (12%)

Query: 251  TVSVADTAQRSVSKYRC--VIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGAT-- 303
            T  +   A    ++YR   V  ++ G G  +   ++  +   P APP   E  A+ AT  
Sbjct: 678  TTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAI 737

Query: 304  -YLWIKPNANSIIGDGPIILKEVEYRTTTGTWA-------ETHIVDSPNYKLWHLDPDVE 355
              LW  P        G I   +V Y    G  A       +  + D+     W  D   E
Sbjct: 738  RVLWRSPAPGR--QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQ----WETDDTAE 791

Query: 356  YEIRVLLTRPGEG-----------GTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLT 404
            YE+ +   +P              G G    P    TK A  V G   + +       L 
Sbjct: 792  YEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGA--VLGRPTLSVQQTPEGSLL 849

Query: 405  LQWEP-FGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLL 463
             +WEP  G A  +   Y L    +   +       E   +   YT  G+    T   RL 
Sbjct: 850  ARWEPPAGTAEDQVLGYRLQFGRE---DSTPLATLEFPPSEDRYTASGVHKGATYVFRLA 906

Query: 464  LSNPEGRMESEELVVQTEEDVPGAVP-LESIQGGPFEEKIYIQWKPP--NETNGVITLYE 520
              +  G  E    V+   ED P   P +    G      + ++W PP   E NG I  Y 
Sbjct: 907  ARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYT 966

Query: 521  INYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKG---FGPP 577
            +  +  G+L P+ +  ++     +   E      GL P T Y   ++A T +G   F PP
Sbjct: 967  VAVREAGALGPARE--TELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPP 1024

Query: 578  VTTR 581
            V  R
Sbjct: 1025 VRYR 1028


>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  434 bits (1117), Expect = e-121
 Identities = 231/584 (39%), Positives = 352/584 (60%), Gaps = 16/584 (2%)

Query: 886  PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYD 944
            P + V  L + I +        F+EE+ ALP     A+ + A ++EN+ KNRY NI+ YD
Sbjct: 210  PPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYD 269

Query: 945  HSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVM 1004
            HSRV L  ++G P SDYINA++I+GY     +IA QGP +ETV DFWRMIW++N+A+IVM
Sbjct: 270  HSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVM 329

Query: 1005 VTNLVEVGRVKCVRYWPDD-TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRE--- 1060
            VTNL E    KC +YWPD     YG+I+V++ +   L +Y +R F +Q+ G    R+   
Sbjct: 330  VTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQR 389

Query: 1061 -LRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTM 1119
             +  FHFTSWPD GVP    G+L F+++VK  NP  AG IVVHCSAG GRTG F+ ID M
Sbjct: 390  LITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAM 449

Query: 1120 LDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLY 1179
            LDM   E  VD++  V  +RAQR  +VQT+ QYVF++ A+LE  L G+T + V    +  
Sbjct: 450  LDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL 509

Query: 1180 YNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLD-RCLP 1238
              I    P T+++ +++EF+ L  +  +++ +    G LP N  KNR + ++P +   + 
Sbjct: 510  QKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVI 567

Query: 1239 FLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMD 1298
              +    E+++Y+NA+ +D ++Q  +++ +Q PL +T+ DFWR+++++   S+VML E++
Sbjct: 568  IPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELE 627

Query: 1299 T--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQY 1356
                + C QYWP      YG I VE    +  E    R   + N    ++  R ++   +
Sbjct: 628  ERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTR--ENKSRQIRQFHF 685

Query: 1357 IGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEM 1416
             GWP     P   + ++ ++  ++K Q+Q  G    T VHC  G GR+GTFCA+ +V E 
Sbjct: 686  HGWPEV-GIPSDGKGMISIIAAVQK-QQQQSGNHPIT-VHCSAGAGRTGTFCALSTVLER 742

Query: 1417 IQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1460
            ++ + I+DVF  VK+LR  + +MV+TLEQY+F Y+V  EY+ +F
Sbjct: 743  VKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF 786


>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
            precursor [Homo sapiens]
          Length = 802

 Score =  434 bits (1117), Expect = e-121
 Identities = 231/584 (39%), Positives = 352/584 (60%), Gaps = 16/584 (2%)

Query: 886  PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYD 944
            P + V  L + I +        F+EE+ ALP     A+ + A ++EN+ KNRY NI+ YD
Sbjct: 219  PPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYD 278

Query: 945  HSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVM 1004
            HSRV L  ++G P SDYINA++I+GY     +IA QGP +ETV DFWRMIW++N+A+IVM
Sbjct: 279  HSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVM 338

Query: 1005 VTNLVEVGRVKCVRYWPDD-TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRE--- 1060
            VTNL E    KC +YWPD     YG+I+V++ +   L +Y +R F +Q+ G    R+   
Sbjct: 339  VTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQR 398

Query: 1061 -LRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTM 1119
             +  FHFTSWPD GVP    G+L F+++VK  NP  AG IVVHCSAG GRTG F+ ID M
Sbjct: 399  LITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAM 458

Query: 1120 LDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLY 1179
            LDM   E  VD++  V  +RAQR  +VQT+ QYVF++ A+LE  L G+T + V    +  
Sbjct: 459  LDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL 518

Query: 1180 YNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLD-RCLP 1238
              I    P T+++ +++EF+ L  +  +++ +    G LP N  KNR + ++P +   + 
Sbjct: 519  QKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVI 576

Query: 1239 FLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMD 1298
              +    E+++Y+NA+ +D ++Q  +++ +Q PL +T+ DFWR+++++   S+VML E++
Sbjct: 577  IPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELE 636

Query: 1299 T--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQY 1356
                + C QYWP      YG I VE    +  E    R   + N    ++  R ++   +
Sbjct: 637  ERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTR--ENKSRQIRQFHF 694

Query: 1357 IGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEM 1416
             GWP     P   + ++ ++  ++K Q+Q  G    T VHC  G GR+GTFCA+ +V E 
Sbjct: 695  HGWPEV-GIPSDGKGMISIIAAVQK-QQQQSGNHPIT-VHCSAGAGRTGTFCALSTVLER 751

Query: 1417 IQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1460
            ++ + I+DVF  VK+LR  + +MV+TLEQY+F Y+V  EY+ +F
Sbjct: 752  VKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF 795


>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  434 bits (1117), Expect = e-121
 Identities = 231/584 (39%), Positives = 352/584 (60%), Gaps = 16/584 (2%)

Query: 886  PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYD 944
            P + V  L + I +        F+EE+ ALP     A+ + A ++EN+ KNRY NI+ YD
Sbjct: 210  PPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYD 269

Query: 945  HSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVM 1004
            HSRV L  ++G P SDYINA++I+GY     +IA QGP +ETV DFWRMIW++N+A+IVM
Sbjct: 270  HSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVM 329

Query: 1005 VTNLVEVGRVKCVRYWPDD-TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRE--- 1060
            VTNL E    KC +YWPD     YG+I+V++ +   L +Y +R F +Q+ G    R+   
Sbjct: 330  VTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQR 389

Query: 1061 -LRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTM 1119
             +  FHFTSWPD GVP    G+L F+++VK  NP  AG IVVHCSAG GRTG F+ ID M
Sbjct: 390  LITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAM 449

Query: 1120 LDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLY 1179
            LDM   E  VD++  V  +RAQR  +VQT+ QYVF++ A+LE  L G+T + V    +  
Sbjct: 450  LDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL 509

Query: 1180 YNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLD-RCLP 1238
              I    P T+++ +++EF+ L  +  +++ +    G LP N  KNR + ++P +   + 
Sbjct: 510  QKIYNKIPGTSNNGLEEEFKKLTSI--KIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVI 567

Query: 1239 FLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMD 1298
              +    E+++Y+NA+ +D ++Q  +++ +Q PL +T+ DFWR+++++   S+VML E++
Sbjct: 568  IPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELE 627

Query: 1299 T--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQY 1356
                + C QYWP      YG I VE    +  E    R   + N    ++  R ++   +
Sbjct: 628  ERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTR--ENKSRQIRQFHF 685

Query: 1357 IGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEM 1416
             GWP     P   + ++ ++  ++K Q+Q  G    T VHC  G GR+GTFCA+ +V E 
Sbjct: 686  HGWPEV-GIPSDGKGMISIIAAVQK-QQQQSGNHPIT-VHCSAGAGRTGTFCALSTVLER 742

Query: 1417 IQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF 1460
            ++ + I+DVF  VK+LR  + +MV+TLEQY+F Y+V  EY+ +F
Sbjct: 743  VKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF 786


>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
            precursor [Homo sapiens]
          Length = 700

 Score =  421 bits (1082), Expect = e-117
 Identities = 230/564 (40%), Positives = 334/564 (59%), Gaps = 16/564 (2%)

Query: 908  FKEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANY 966
            F+EE+ +LP G    +++ A ++ENR KNRY NI+  DHSRV L  LDG P SDYINA+Y
Sbjct: 135  FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 194

Query: 967  IDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD-TE 1025
            IDGY     +IA QGP QETV DFWRM+W++ SA+IVM+TNL E    KC +YWPD    
Sbjct: 195  IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 254

Query: 1026 VYGDIKVTLIETEPLAEYVIRTFTVQKK---GYHEIRELRLFHFTSWPDHGVPCYATGLL 1082
             YG+I+V + +   L +Y IR F +Q +   G    R +   HFTSWPD GVP    G+L
Sbjct: 255  TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 314

Query: 1083 GFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQR 1142
             F+++VK LNP  AGPIVVHCSAG GRTG FI ID M+ M   E  VD+F  V  +R QR
Sbjct: 315  KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 374

Query: 1143 VNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLN 1202
              +VQT+ QY F++ A+LE  L G+T + V         +       +   +++EF+ L 
Sbjct: 375  PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 434

Query: 1203 IVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQ 1261
             V  R+  E+   G LP N  K R + ++P D     L    G E ++YINA+ +D ++Q
Sbjct: 435  NV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 492

Query: 1262 PAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQ--FCMQYWPEKTSGCYGPIQ 1319
               F+ TQ PL +TV DFWR+++++   ++VML E+   +   C QYWP + S  +G I 
Sbjct: 493  KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEIT 552

Query: 1320 VEFVSADIDEDIIHRIFRIC---NMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVV 1376
            +E  +  + E I  R F +      AR ++  R+V+   + GWP     P   + ++ ++
Sbjct: 553  IEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDLI 611

Query: 1377 RRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNK 1436
              ++K Q+Q         VHC  G GR+GTF A+ ++ E ++ + ++DVF  VK+LR  +
Sbjct: 612  AAVQKQQQQTGNHP--ITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQR 669

Query: 1437 SNMVETLEQYKFVYEVALEYLSSF 1460
             +MV+TLEQY+F Y+V  +++  F
Sbjct: 670  PHMVQTLEQYEFCYKVVQDFIDIF 693


>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
            [Homo sapiens]
          Length = 642

 Score =  421 bits (1082), Expect = e-117
 Identities = 230/564 (40%), Positives = 334/564 (59%), Gaps = 16/564 (2%)

Query: 908  FKEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANY 966
            F+EE+ +LP G    +++ A ++ENR KNRY NI+  DHSRV L  LDG P SDYINA+Y
Sbjct: 77   FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 136

Query: 967  IDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD-TE 1025
            IDGY     +IA QGP QETV DFWRM+W++ SA+IVM+TNL E    KC +YWPD    
Sbjct: 137  IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 196

Query: 1026 VYGDIKVTLIETEPLAEYVIRTFTVQKK---GYHEIRELRLFHFTSWPDHGVPCYATGLL 1082
             YG+I+V + +   L +Y IR F +Q +   G    R +   HFTSWPD GVP    G+L
Sbjct: 197  TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 256

Query: 1083 GFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQR 1142
             F+++VK LNP  AGPIVVHCSAG GRTG FI ID M+ M   E  VD+F  V  +R QR
Sbjct: 257  KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 316

Query: 1143 VNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLN 1202
              +VQT+ QY F++ A+LE  L G+T + V         +       +   +++EF+ L 
Sbjct: 317  PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 376

Query: 1203 IVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQ 1261
             V  R+  E+   G LP N  K R + ++P D     L    G E ++YINA+ +D ++Q
Sbjct: 377  NV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 434

Query: 1262 PAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQ--FCMQYWPEKTSGCYGPIQ 1319
               F+ TQ PL +TV DFWR+++++   ++VML E+   +   C QYWP + S  +G I 
Sbjct: 435  KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEIT 494

Query: 1320 VEFVSADIDEDIIHRIFRIC---NMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVV 1376
            +E  +  + E I  R F +      AR ++  R+V+   + GWP     P   + ++ ++
Sbjct: 495  IEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDLI 553

Query: 1377 RRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNK 1436
              ++K Q+Q         VHC  G GR+GTF A+ ++ E ++ + ++DVF  VK+LR  +
Sbjct: 554  AAVQKQQQQTGNHP--ITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQR 611

Query: 1437 SNMVETLEQYKFVYEVALEYLSSF 1460
             +MV+TLEQY+F Y+V  +++  F
Sbjct: 612  PHMVQTLEQYEFCYKVVQDFIDIF 635


>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
            precursor [Homo sapiens]
          Length = 2315

 Score =  394 bits (1012), Expect = e-109
 Identities = 233/631 (36%), Positives = 356/631 (56%), Gaps = 59/631 (9%)

Query: 866  THPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPE-------- 917
            T P     P    +P      AI +    +H+  +    G  F EE+E L E        
Sbjct: 1677 TSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSG--FTEEFETLKEFYQEVQSC 1734

Query: 918  ----GQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVL---DGDPHSDYINANYIDGY 970
                G TA  D++   +N++KNRY NI++YDHSRV+L  L   DG   +DYINANY+DGY
Sbjct: 1735 TVDLGITA--DSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKL-TDYINANYVDGY 1791

Query: 971  HRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP-DDTEVYGD 1029
            +RP+ YIA QGP++ T +DFWRMIW+ N   IVM+TNLVE GR KC +YWP D +E YG+
Sbjct: 1792 NRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGN 1851

Query: 1030 IKVTLIETEPLAEYVIRTFTVQ--------KKGYHEIRELRLFHFTSWPDHGVPCYATGL 1081
              VT    + LA Y +R FT++        +KG    R +  +H+T WPD GVP Y+  +
Sbjct: 1852 FLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPV 1911

Query: 1082 LGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQ 1141
            L FVR+  +      GP+VVHCSAG GRTG +I +D+ML   ++EG V+IF  ++ +R+Q
Sbjct: 1912 LTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQ 1971

Query: 1142 RVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTL 1201
            R  LVQTEEQYVF+HD ++EA L   T +      + Y N   +      ++++ +FQ L
Sbjct: 1972 RNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHA-YVNALLIPGPAGKTKLEKQFQLL 2030

Query: 1202 NIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQ 1261
            +     ++  D S  L   N +KNR+  ++P++R    + S+ GE ++YINA+ +  + Q
Sbjct: 2031 S--QSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQ 2088

Query: 1262 PAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNE-MDTAQFCMQYWPEKTSGCYGPIQV 1320
               F++TQHPL +T+ DFWR+++D+N   VVM+ +  + A+    YWP K      PI  
Sbjct: 2089 SNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDE----PINC 2144

Query: 1321 EFVSADI----------DEDIIHRIFRICNMARPQDGYRI-VQHLQYIGWPAYRDTPPSK 1369
            E     +          +E +I + F    +   QD Y + V+H Q   WP   D+P SK
Sbjct: 2145 ESFKVTLMAEEHKCLSNEEKLIIQDF---ILEATQDDYVLEVRHFQCPKWP-NPDSPISK 2200

Query: 1370 R-SLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHI 1428
               L+ V++      E+   R+G  +VH  +GG  +GTFCA+ ++   ++++N +DV+ +
Sbjct: 2201 TFELISVIK------EEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQV 2254

Query: 1429 VKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1459
             K +   +  +   +EQY+F+Y+V L  +S+
Sbjct: 2255 AKMINLMRPGVFADIEQYQFLYKVILSLVST 2285


>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
            [Homo sapiens]
          Length = 1445

 Score =  380 bits (976), Expect = e-105
 Identities = 230/657 (35%), Positives = 359/657 (54%), Gaps = 54/657 (8%)

Query: 831  SASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRV 890
            S  R ++G     Q  + + + S      P  +I   P     P +M         AI V
Sbjct: 783  SGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPI----PDDME--------AIPV 830

Query: 891  ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKED---ENRNKNRYGNIISYDHSR 947
               ++HI ++     +GF E++E +         TA+     EN++KNRY NI++YDHSR
Sbjct: 831  KQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSR 890

Query: 948  VRLLVLDG--DPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMV 1005
            V+L  L G    HSDYINANY+DGY++ + YIATQGP++ T +DFWRMIW++N+  IVM+
Sbjct: 891  VKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMI 950

Query: 1006 TNLVEVGRVKCVRYWP-DDTEVYGDIKVTLIETEPLAEYVIRTFTVQK-----------K 1053
            TNLVE GR KC +YWP +++E YG+I VTL  T+  A Y +R F+++            K
Sbjct: 951  TNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPK 1010

Query: 1054 GYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCF 1113
            G    R +  +H+T WPD GVP YA  +L FVR+      PE GP++VHCSAG GRTG +
Sbjct: 1011 GRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTY 1070

Query: 1114 IAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVC 1173
            I ID+ML   +++  V++   ++ +R QR  LVQTEEQY+F+HDA+LEA L   T +   
Sbjct: 1071 IVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSN 1130

Query: 1174 EFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPL 1233
            +  S Y N   +      ++++ +F+   +     +  +C       N +KNR+  V+P 
Sbjct: 1131 QLHS-YVNSILIPGVGGKTRLEKQFKL--VTQCNAKYVECFSAQKECNKEKNRNSSVVPS 1187

Query: 1234 DRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVV 1292
            +R    L  + G + ++YINA+ +  + +   F++TQHPLP+T  DFWR+++D+N   +V
Sbjct: 1188 ERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIV 1247

Query: 1293 ML-NEMDTAQFCMQYWP--EKTSGCYGPIQVEFVSAD------IDEDIIHRIFRICNMAR 1343
            ML +    A+    YWP  E++  C     V  +S D       ++ IIH       +  
Sbjct: 1248 MLPDNQSLAEDEFVYWPSREESMNCEA-FTVTLISKDRLCLSNEEQIIIHDFI----LEA 1302

Query: 1344 PQDGYRI-VQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGG 1402
             QD Y + V+H Q   WP       S   L+ V++      E+   R+G T+VH   G  
Sbjct: 1303 TQDDYVLEVRHFQCPKWPNPDAPISSTFELINVIK------EEALTRDGPTIVHDEYGAV 1356

Query: 1403 RSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1459
             +G  CA+ ++ + ++ +N +DVF + K +   +  +   +EQY+F+Y+  L  +S+
Sbjct: 1357 SAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST 1413


>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
            precursor [Homo sapiens]
          Length = 1256

 Score =  356 bits (913), Expect = 1e-97
 Identities = 219/628 (34%), Positives = 328/628 (52%), Gaps = 50/628 (7%)

Query: 867  HPYRTC--DPVEMSYPRDQFQPAIRV----ADLLQHITQMK-RGQGYGFKEEYEALPEGQ 919
            H  R+C  D  +    RD  +  + V    AD+L    + K   +G  F  E++++P   
Sbjct: 555  HKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVF 614

Query: 920  TA-SWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIA 978
            +      A++  N+NKNRY +I+ YD++RV L  ++GD  S+YINA+YIDG+  PR YIA
Sbjct: 615  SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA 674

Query: 979  TQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP---DDTEVYGDIKVTLI 1035
             QGP  ETV DFWRMIW++ +  IVMVT   E  R KC  YWP   + T  +GD+ V + 
Sbjct: 675  AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKIN 734

Query: 1036 ETEPLAEYVIRTFT-VQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPP 1094
            + +   +Y+I+    V KK     RE+    FTSWPDHGVP     LL   R+V   +  
Sbjct: 735  QHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF 794

Query: 1095 EAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVF 1154
             +GPIVVHCSAG GRTG +I ID ML+  E E  VD++  V +LR QR  +VQ E QY+ 
Sbjct: 795  FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYIL 854

Query: 1155 VHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRP-EDC 1213
            +H A++E    G T + + E     +N+ + DP +  S ++ EFQ L    P  R     
Sbjct: 855  IHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRL----PSYRSWRTQ 910

Query: 1214 SIGLLPRNHDKNRSMDVLPLD-RCLPFLISVD-------------------GESSNYINA 1253
             IG    N  KNR+ +V+P D   +P    ++                    E S YINA
Sbjct: 911  HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINA 970

Query: 1254 ALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKT 1311
            + + S+ +P   +  Q PL  T+ DFW+++F      +VML E+     + C QYW E  
Sbjct: 971  SFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK 1030

Query: 1312 SGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRS 1371
               YG I+V+    D       R+F + +  R     R V   QY  W +    P   + 
Sbjct: 1031 Q-TYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKE 1086

Query: 1372 LLKVVRRLEKWQEQYDGREGR-------TVVHCLNGGGRSGTFCAICSVCEMIQQQNIID 1424
            L+ +++ +++   Q +  EG         ++HC +G  ++G FCA+ ++ E  + + ++D
Sbjct: 1087 LISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVD 1146

Query: 1425 VFHIVKTLRNNKSNMVETLEQYKFVYEV 1452
            +F +VK LR  +  MV T EQY+F+Y+V
Sbjct: 1147 IFQVVKALRKARPGMVSTFEQYQFLYDV 1174



 Score =  165 bits (417), Expect = 3e-40
 Identities = 100/308 (32%), Positives = 162/308 (52%), Gaps = 38/308 (12%)

Query: 888  IRVADLLQHITQMKR----GQGYGFKEEYEALPEGQTASWDT---AKEDENRNKNRYGNI 940
            + +++L  ++  MK+     +    + E++ LP  +  SW T     ++EN++KNR  N+
Sbjct: 870  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYR--SWRTQHIGNQEENKSKNRNSNV 927

Query: 941  ISYDHSRVRLL---------VLDGDPHSD----------YINANYIDGYHRPRHYIATQG 981
            I YD++RV L            D D  SD          YINA++I  Y +P   IA QG
Sbjct: 928  IPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQG 987

Query: 982  PMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLA 1041
            P++ET+ DFW+MI+Q     IVM+T L    +  C +YW +  + YGDI+V L +T+  +
Sbjct: 988  PLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSS 1047

Query: 1042 EYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPE------ 1095
             Y +R F ++     + R +  + +T+W    +P     L+  ++ VK   P +      
Sbjct: 1048 TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 1107

Query: 1096 ----AGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQ 1151
                + P+++HC  G+ +TG F A+  +L+ AE E VVDIF  V+ LR  R  +V T EQ
Sbjct: 1108 KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1167

Query: 1152 YVFVHDAI 1159
            Y F++D I
Sbjct: 1168 YQFLYDVI 1175



 Score =  131 bits (330), Expect = 4e-30
 Identities = 79/243 (32%), Positives = 125/243 (51%), Gaps = 10/243 (4%)

Query: 1219 PRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVVTQHPLPNTVA 1277
            P N +KNR +D+LP D     L  ++G++ SNYINA+ +D  K+P  ++  Q P   TV 
Sbjct: 625  PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 684

Query: 1278 DFWRLVFDYNCSSVVMLN--EMDTAQFCMQYWPEKTSG--CYGPIQVEFVSADIDEDIIH 1333
            DFWR++++   + +VM+   E      C +YWP    G   +G + V+        D I 
Sbjct: 685  DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 744

Query: 1334 RIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRT 1393
            +   I N      G R V H+Q+  WP +   P     LLK+ RR+  +   + G     
Sbjct: 745  QKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAFSNFFSGP---I 799

Query: 1394 VVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVA 1453
            VVHC  G GR+GT+  I ++ E ++ +N +DV+  V  LR  +  MV+   QY  +++  
Sbjct: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859

Query: 1454 LEY 1456
            +EY
Sbjct: 860  VEY 862


>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
            precursor [Homo sapiens]
          Length = 1304

 Score =  356 bits (913), Expect = 1e-97
 Identities = 219/628 (34%), Positives = 328/628 (52%), Gaps = 50/628 (7%)

Query: 867  HPYRTC--DPVEMSYPRDQFQPAIRV----ADLLQHITQMK-RGQGYGFKEEYEALPEGQ 919
            H  R+C  D  +    RD  +  + V    AD+L    + K   +G  F  E++++P   
Sbjct: 603  HKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVF 662

Query: 920  TA-SWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIA 978
            +      A++  N+NKNRY +I+ YD++RV L  ++GD  S+YINA+YIDG+  PR YIA
Sbjct: 663  SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA 722

Query: 979  TQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP---DDTEVYGDIKVTLI 1035
             QGP  ETV DFWRMIW++ +  IVMVT   E  R KC  YWP   + T  +GD+ V + 
Sbjct: 723  AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKIN 782

Query: 1036 ETEPLAEYVIRTFT-VQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPP 1094
            + +   +Y+I+    V KK     RE+    FTSWPDHGVP     LL   R+V   +  
Sbjct: 783  QHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF 842

Query: 1095 EAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVF 1154
             +GPIVVHCSAG GRTG +I ID ML+  E E  VD++  V +LR QR  +VQ E QY+ 
Sbjct: 843  FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYIL 902

Query: 1155 VHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRP-EDC 1213
            +H A++E    G T + + E     +N+ + DP +  S ++ EFQ L    P  R     
Sbjct: 903  IHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRL----PSYRSWRTQ 958

Query: 1214 SIGLLPRNHDKNRSMDVLPLD-RCLPFLISVD-------------------GESSNYINA 1253
             IG    N  KNR+ +V+P D   +P    ++                    E S YINA
Sbjct: 959  HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINA 1018

Query: 1254 ALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKT 1311
            + + S+ +P   +  Q PL  T+ DFW+++F      +VML E+     + C QYW E  
Sbjct: 1019 SFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK 1078

Query: 1312 SGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRS 1371
               YG I+V+    D       R+F + +  R     R V   QY  W +    P   + 
Sbjct: 1079 Q-TYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKE 1134

Query: 1372 LLKVVRRLEKWQEQYDGREGR-------TVVHCLNGGGRSGTFCAICSVCEMIQQQNIID 1424
            L+ +++ +++   Q +  EG         ++HC +G  ++G FCA+ ++ E  + + ++D
Sbjct: 1135 LISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVD 1194

Query: 1425 VFHIVKTLRNNKSNMVETLEQYKFVYEV 1452
            +F +VK LR  +  MV T EQY+F+Y+V
Sbjct: 1195 IFQVVKALRKARPGMVSTFEQYQFLYDV 1222



 Score =  165 bits (417), Expect = 3e-40
 Identities = 100/308 (32%), Positives = 162/308 (52%), Gaps = 38/308 (12%)

Query: 888  IRVADLLQHITQMKR----GQGYGFKEEYEALPEGQTASWDT---AKEDENRNKNRYGNI 940
            + +++L  ++  MK+     +    + E++ LP  +  SW T     ++EN++KNR  N+
Sbjct: 918  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYR--SWRTQHIGNQEENKSKNRNSNV 975

Query: 941  ISYDHSRVRLL---------VLDGDPHSD----------YINANYIDGYHRPRHYIATQG 981
            I YD++RV L            D D  SD          YINA++I  Y +P   IA QG
Sbjct: 976  IPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQG 1035

Query: 982  PMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLA 1041
            P++ET+ DFW+MI+Q     IVM+T L    +  C +YW +  + YGDI+V L +T+  +
Sbjct: 1036 PLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSS 1095

Query: 1042 EYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPE------ 1095
             Y +R F ++     + R +  + +T+W    +P     L+  ++ VK   P +      
Sbjct: 1096 TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 1155

Query: 1096 ----AGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQ 1151
                + P+++HC  G+ +TG F A+  +L+ AE E VVDIF  V+ LR  R  +V T EQ
Sbjct: 1156 KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1215

Query: 1152 YVFVHDAI 1159
            Y F++D I
Sbjct: 1216 YQFLYDVI 1223



 Score =  131 bits (330), Expect = 4e-30
 Identities = 79/243 (32%), Positives = 125/243 (51%), Gaps = 10/243 (4%)

Query: 1219 PRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVVTQHPLPNTVA 1277
            P N +KNR +D+LP D     L  ++G++ SNYINA+ +D  K+P  ++  Q P   TV 
Sbjct: 673  PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 732

Query: 1278 DFWRLVFDYNCSSVVMLN--EMDTAQFCMQYWPEKTSG--CYGPIQVEFVSADIDEDIIH 1333
            DFWR++++   + +VM+   E      C +YWP    G   +G + V+        D I 
Sbjct: 733  DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 792

Query: 1334 RIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRT 1393
            +   I N      G R V H+Q+  WP +   P     LLK+ RR+  +   + G     
Sbjct: 793  QKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAFSNFFSGP---I 847

Query: 1394 VVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVA 1453
            VVHC  G GR+GT+  I ++ E ++ +N +DV+  V  LR  +  MV+   QY  +++  
Sbjct: 848  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907

Query: 1454 LEY 1456
            +EY
Sbjct: 908  VEY 910


>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
            precursor [Homo sapiens]
          Length = 1143

 Score =  356 bits (913), Expect = 1e-97
 Identities = 219/628 (34%), Positives = 328/628 (52%), Gaps = 50/628 (7%)

Query: 867  HPYRTC--DPVEMSYPRDQFQPAIRV----ADLLQHITQMK-RGQGYGFKEEYEALPEGQ 919
            H  R+C  D  +    RD  +  + V    AD+L    + K   +G  F  E++++P   
Sbjct: 442  HKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVF 501

Query: 920  TA-SWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIA 978
            +      A++  N+NKNRY +I+ YD++RV L  ++GD  S+YINA+YIDG+  PR YIA
Sbjct: 502  SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA 561

Query: 979  TQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP---DDTEVYGDIKVTLI 1035
             QGP  ETV DFWRMIW++ +  IVMVT   E  R KC  YWP   + T  +GD+ V + 
Sbjct: 562  AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKIN 621

Query: 1036 ETEPLAEYVIRTFT-VQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPP 1094
            + +   +Y+I+    V KK     RE+    FTSWPDHGVP     LL   R+V   +  
Sbjct: 622  QHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNF 681

Query: 1095 EAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVF 1154
             +GPIVVHCSAG GRTG +I ID ML+  E E  VD++  V +LR QR  +VQ E QY+ 
Sbjct: 682  FSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYIL 741

Query: 1155 VHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRP-EDC 1213
            +H A++E    G T + + E     +N+ + DP +  S ++ EFQ L    P  R     
Sbjct: 742  IHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRL----PSYRSWRTQ 797

Query: 1214 SIGLLPRNHDKNRSMDVLPLD-RCLPFLISVD-------------------GESSNYINA 1253
             IG    N  KNR+ +V+P D   +P    ++                    E S YINA
Sbjct: 798  HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINA 857

Query: 1254 ALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKT 1311
            + + S+ +P   +  Q PL  T+ DFW+++F      +VML E+     + C QYW E  
Sbjct: 858  SFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK 917

Query: 1312 SGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRS 1371
               YG I+V+    D       R+F + +  R     R V   QY  W +    P   + 
Sbjct: 918  Q-TYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS--RTVYQYQYTNW-SVEQLPAEPKE 973

Query: 1372 LLKVVRRLEKWQEQYDGREGR-------TVVHCLNGGGRSGTFCAICSVCEMIQQQNIID 1424
            L+ +++ +++   Q +  EG         ++HC +G  ++G FCA+ ++ E  + + ++D
Sbjct: 974  LISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVD 1033

Query: 1425 VFHIVKTLRNNKSNMVETLEQYKFVYEV 1452
            +F +VK LR  +  MV T EQY+F+Y+V
Sbjct: 1034 IFQVVKALRKARPGMVSTFEQYQFLYDV 1061



 Score =  165 bits (417), Expect = 3e-40
 Identities = 100/308 (32%), Positives = 162/308 (52%), Gaps = 38/308 (12%)

Query: 888  IRVADLLQHITQMKR----GQGYGFKEEYEALPEGQTASWDT---AKEDENRNKNRYGNI 940
            + +++L  ++  MK+     +    + E++ LP  +  SW T     ++EN++KNR  N+
Sbjct: 757  VNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYR--SWRTQHIGNQEENKSKNRNSNV 814

Query: 941  ISYDHSRVRLL---------VLDGDPHSD----------YINANYIDGYHRPRHYIATQG 981
            I YD++RV L            D D  SD          YINA++I  Y +P   IA QG
Sbjct: 815  IPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQG 874

Query: 982  PMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLA 1041
            P++ET+ DFW+MI+Q     IVM+T L    +  C +YW +  + YGDI+V L +T+  +
Sbjct: 875  PLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSS 934

Query: 1042 EYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPE------ 1095
             Y +R F ++     + R +  + +T+W    +P     L+  ++ VK   P +      
Sbjct: 935  TYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 994

Query: 1096 ----AGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQ 1151
                + P+++HC  G+ +TG F A+  +L+ AE E VVDIF  V+ LR  R  +V T EQ
Sbjct: 995  KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQ 1054

Query: 1152 YVFVHDAI 1159
            Y F++D I
Sbjct: 1055 YQFLYDVI 1062



 Score =  131 bits (330), Expect = 4e-30
 Identities = 79/243 (32%), Positives = 125/243 (51%), Gaps = 10/243 (4%)

Query: 1219 PRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVVTQHPLPNTVA 1277
            P N +KNR +D+LP D     L  ++G++ SNYINA+ +D  K+P  ++  Q P   TV 
Sbjct: 512  PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVD 571

Query: 1278 DFWRLVFDYNCSSVVMLN--EMDTAQFCMQYWPEKTSG--CYGPIQVEFVSADIDEDIIH 1333
            DFWR++++   + +VM+   E      C +YWP    G   +G + V+        D I 
Sbjct: 572  DFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYII 631

Query: 1334 RIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRT 1393
            +   I N      G R V H+Q+  WP +   P     LLK+ RR+  +   + G     
Sbjct: 632  QKLNIVNKKEKATG-REVTHIQFTSWPDH-GVPEDPHLLLKLRRRVNAFSNFFSGP---I 686

Query: 1394 VVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVA 1453
            VVHC  G GR+GT+  I ++ E ++ +N +DV+  V  LR  +  MV+   QY  +++  
Sbjct: 687  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746

Query: 1454 LEY 1456
            +EY
Sbjct: 747  VEY 749


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,855,390
Number of Sequences: 37866
Number of extensions: 2848939
Number of successful extensions: 10147
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 139
Number of HSP's successfully gapped in prelim test: 123
Number of HSP's that attempted gapping in prelim test: 7948
Number of HSP's gapped (non-prelim): 1290
length of query: 1460
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1345
effective length of database: 13,892,928
effective search space: 18685988160
effective search space used: 18685988160
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.